FN Thomson Reuters Web of Science™ VR 1.0 PT J AU TAMURA, JK GELLERT, M AF TAMURA, JK GELLERT, M TI CHARACTERIZATION OF THE ATP BINDING-SITE ON ESCHERICHIA-COLI DNA GYRASE - AFFINITY LABELING OF LYS-103 AND LYS-110 OF THE B-SUBUNIT BY PYRIDOXAL 5'-DIPHOSPHO-5'-ADENOSINE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP TAMURA, JK (reprint author), NIAID,MOLEC BIOL LAB,BETHESDA,MD 20892, USA. NR 55 TC 72 Z9 75 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD DEC 5 PY 1990 VL 265 IS 34 BP 21342 EP 21349 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL020 UT WOS:A1990EL02000095 PM 2174443 ER PT J AU SCHOENLEIN, PV GOTTESMAN, MM AF SCHOENLEIN, PV GOTTESMAN, MM TI EXTRACHROMOSOMAL DNA IN HUMAN CANCERS SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Editorial Material C1 NCI,CELL BIOL LAB,BETHESDA,MD 20892. NR 23 TC 4 Z9 4 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1798 EP 1800 DI 10.1093/jnci/82.23.1798 PG 3 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200001 PM 2250291 ER PT J AU BROWN, ML AF BROWN, ML TI THE NATIONAL ECONOMIC BURDEN OF CANCER - AN UPDATE SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article C1 NCI,DIV CANC PREVENT & CONTROL,SURVEILLANCE PROGRAM,APPL RES BRANCH,BETHESDA,MD 20892. NR 17 TC 48 Z9 49 U1 0 U2 1 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1811 EP 1814 DI 10.1093/jnci/82.23.1811 PG 4 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200009 PM 2250295 ER PT J AU HOCHMAN, J PARK, SS LAZAROVICI, P BERGEL, M GOTTESMAN, MM AF HOCHMAN, J PARK, SS LAZAROVICI, P BERGEL, M GOTTESMAN, MM TI MONOCLONAL-ANTIBODIES TO IMMUNOGENIC LYMPHOMA CELL VARIANTS DISPLAYING IMPAIRED NEOPLASTIC PROPERTIES - CHARACTERIZATION AND APPLICATIONS SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article C1 NCI,DIV CANC ETIOL,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892. NCI,DIV CANC ETIOL,CELL BIOL LAB,BETHESDA,MD 20892. RP HOCHMAN, J (reprint author), HEBREW UNIV JERUSALEM,DEPT ZOOL,IL-91904 JERUSALEM,ISRAEL. FU NCI NIH HHS [CA-48146] NR 16 TC 14 Z9 14 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1821 EP 1826 DI 10.1093/jnci/82.23.1821 PG 6 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200011 PM 2250297 ER PT J AU BARTSCH, H CAPORASO, N CODA, M KADLUBAR, F MALAVEILLE, C SKIPPER, P TALASKA, G TANNENBAUM, SR VINEIS, P AF BARTSCH, H CAPORASO, N CODA, M KADLUBAR, F MALAVEILLE, C SKIPPER, P TALASKA, G TANNENBAUM, SR VINEIS, P TI CARCINOGEN HEMOGLOBIN ADDUCTS, URINARY MUTAGENICITY, AND METABOLIC PHENOTYPE IN ACTIVE AND PASSIVE CIGARETTE SMOKERS SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article C1 DIPARTIMENTO SCI BIOMED & ONCOL UMANA,CANC EPIDEMIOL UNIT,VIA SANTENA 7,I-10126 TURIN,ITALY. INT AGCY RES CANC,F-69372 LYONS,FRANCE. NCI,DIV CANC ETIOL,FAMILY STUDIES SECT,BETHESDA,MD 20892. NATL CTR TOXICOL RES,JEFFERSON,AR 72079. MIT,DEPT CHEM,DIV TOXICOL,CAMBRIDGE,MA 02139. UNIV CINCINNATI,CINCINNATI,OH 45221. NR 31 TC 126 Z9 126 U1 1 U2 5 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1826 EP 1831 DI 10.1093/jnci/82.23.1826 PG 6 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200012 PM 2250298 ER PT J AU BECKNER, ME STRACKE, ML LIOTTA, LA SCHIFFMANN, E AF BECKNER, ME STRACKE, ML LIOTTA, LA SCHIFFMANN, E TI GLYCOLYSIS AS PRIMARY ENERGY-SOURCE IN TUMOR-CELL CHEMOTAXIS SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article C1 NCI,PATHOL LAB,BETHESDA,MD 20892. NR 37 TC 89 Z9 90 U1 0 U2 2 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1836 EP 1840 DI 10.1093/jnci/82.23.1836 PG 5 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200014 PM 2174462 ER PT J AU SMIGEL, K VANNEVEL, JP AF SMIGEL, K VANNEVEL, JP TI BETA-CAROTENE DIDNT PREVENT CANCER - WHATS UP DOC - RESPONSE SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter RP SMIGEL, K (reprint author), NCI,OFF CANC COMMUN,BLDG 31,RM 10A29,BETHESDA,MD 20892, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1853 EP 1853 DI 10.1093/jnci/82.23.1853 PG 1 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200018 ER PT J AU GAIL, MH AF GAIL, MH TI MODELS THAT PREDICT THE RISK OF DEVELOPING BREAST-CANCER - RESPONSE SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter RP GAIL, MH (reprint author), NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,EXECUT PLAZA N,RM 403,BETHESDA,MD 20892, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 5 PY 1990 VL 82 IS 23 BP 1854 EP 1855 DI 10.1093/jnci/82.23.1854 PG 2 WC Oncology SC Oncology GA EL292 UT WOS:A1990EL29200020 ER PT J AU KUMAR, A WILSON, SH AF KUMAR, A WILSON, SH TI STUDIES OF THE STRAND-ANNEALING ACTIVITY OF MAMMALIAN HNRNP COMPLEX PROTEIN-A1 SO BIOCHEMISTRY LA English DT Article C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892. NR 34 TC 110 Z9 110 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD DEC 4 PY 1990 VL 29 IS 48 BP 10717 EP 10722 DI 10.1021/bi00500a001 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL364 UT WOS:A1990EL36400001 PM 1703006 ER PT J AU POCALYKO, DJ CARROLL, LJ MARTIN, BM BABBITT, PC DUNAWAYMARIANO, D AF POCALYKO, DJ CARROLL, LJ MARTIN, BM BABBITT, PC DUNAWAYMARIANO, D TI ANALYSIS OF SEQUENCE HOMOLOGIES IN PLANT AND BACTERIAL PYRUVATE PHOSPHATE DIKINASE, ENZYME-I OF THE BACTERIAL PHOSPHOENOLPYRUVATE - SUGAR PHOSPHOTRANSFERASE SYSTEM AND OTHER PEP-UTILIZING ENZYMES - IDENTIFICATION OF POTENTIAL CATALYTIC AND REGULATORY MOTIFS SO BIOCHEMISTRY LA English DT Article C1 UNIV MARYLAND,DEPT CHEM & BIOCHEM,COLLEGE PK,MD 20742. NIMH,CLIN NEUROSCI BRANCH,MOLEC NEUROGENET UNIT,BETHESDA,MD 20892. UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143. FU NIGMS NIH HHS [GM-36260, GM-28688] NR 57 TC 82 Z9 86 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD DEC 4 PY 1990 VL 29 IS 48 BP 10757 EP 10765 DI 10.1021/bi00500a006 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL364 UT WOS:A1990EL36400006 PM 2176881 ER PT J AU CHANG, KSS GAO, C WANG, LC AF CHANG, KSS GAO, C WANG, LC TI BERBERINE-INDUCED MORPHOLOGICAL-DIFFERENTIATION AND DOWN-REGULATION OF C-KI-RAS2 PROTOONCOGENE EXPRESSION IN HUMAN TERATOCARCINOMA CELLS SO CANCER LETTERS LA English DT Article DE TERATOCARCINOMA; DIFFERENTIATION; BERBERINE; KI-RAS PROTOONCOGENE ID RETINOIC ACID; INHIBITION; INDUCTION; ALKALOIDS; BINDING; AGENTS AB A pluripotent human teratocarcinoma cell clone, NT2/D1, which was derived from the Tera-2 cell line, was induced to differentiate into cells with neuronal cell morphology by treatment with berberine. As early as 1 day after a 24-h treatment of cells with berberine at a non-toxic dose of 0.1 mg/ml in culture medium, the cells started to show morphologic changes, developing into terminally differentiated neuronal cells with long, inter-connecting network-like cellular structures. This process is much faster as compared with that induced by treatment with retinoic acid (RA), which took at least several days to develop. Unlike RA, berberine could not induce murine teratocarcinoma cell line, F9, to differentiate into endodermal cells. It was also found that, although the NT2/D1 cell clone exhibited amplification and enhanced mRNA expression of c-Ki-ras2 gene as did the parent cell line, a marked down-regulation of c-Ki-ras2 mRNA expression was observed. However, there was no change in actin mRNA expression even after differentiation had occurred. Thus, morphologic differentiation of teratocarcinoma cells into neuronal cells is found to be associated with down-regulation of a protooncogene which plays some definite role in oncogenesis. The mechanism by which berberine induces differentiation in these cells needs further investigation. C1 NCI,CELLULAR ONCOL LAB,BETHESDA,MD 20892. RP CHANG, KSS (reprint author), CHANG GUNG MEM HOSP,MED RES CTR,TAOYUAN HSIEN,TAIWAN. NR 19 TC 16 Z9 21 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0304-3835 J9 CANCER LETT JI Cancer Lett. PD DEC 3 PY 1990 VL 55 IS 2 BP 103 EP 108 DI 10.1016/0304-3835(90)90018-S PG 6 WC Oncology SC Oncology GA EP523 UT WOS:A1990EP52300004 PM 2265407 ER PT J AU ALEMANY, J GIRBAU, M BASSAS, L DEPABLO, F AF ALEMANY, J GIRBAU, M BASSAS, L DEPABLO, F TI INSULIN-RECEPTORS AND INSULIN-LIKE GROWTH FACTOR-I RECEPTORS ARE FUNCTIONAL DURING ORGANOGENESIS OF THE LENS SO MOLECULAR AND CELLULAR ENDOCRINOLOGY LA English DT Article C1 NIDDK,DIABET BRANCH,RECEPTORS & HORMONE ACT SECT,BLDG 10,ROOM 8S-243,BETHESDA,MD 20892. HOSP SANTA CRUZ & SAN PABLO,BARCELONA,SPAIN. NR 43 TC 20 Z9 20 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0303-7207 J9 MOL CELL ENDOCRINOL JI Mol. Cell. Endocrinol. PD DEC 3 PY 1990 VL 74 IS 2 BP 155 EP 162 DI 10.1016/0303-7207(90)90117-Q PG 8 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA EM831 UT WOS:A1990EM83100009 PM 1965308 ER PT J AU MACDONALD, AB BERGER, BW SCHWAN, TG AF MACDONALD, AB BERGER, BW SCHWAN, TG TI CLINICAL IMPLICATIONS OF DELAYED GROWTH OF THE LYME BORRELIOSIS SPIROCHETE, BORRELIA-BURGDORFERI SO ACTA TROPICA LA English DT Article C1 NYU,SCH MED,DEPT DERMATOL,NEW YORK,NY 10003. NIAID,ARTHROPOD BORNE DIS SECT,VECTORS & PATHOGENS LAB,ROCKY MT LABS,HAMILTON,MT. RP MACDONALD, AB (reprint author), SOUTHAMPTON HOSP,DEPT PATHOL,SOUTHAMPTON,NY 11968, USA. NR 31 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X J9 ACTA TROP JI Acta Trop. PD DEC PY 1990 VL 48 IS 2 BP 89 EP 94 DI 10.1016/0001-706X(90)90047-4 PG 6 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA EL741 UT WOS:A1990EL74100002 PM 1980573 ER PT J AU ROMANO, CA AF ROMANO, CA TI DIFFUSION OF TECHNOLOGY INNOVATION SO ADVANCES IN NURSING SCIENCE LA English DT Article RP ROMANO, CA (reprint author), NIH,CTR CLIN,DEPT NURSING,BETHESDA,MD 20892, USA. NR 27 TC 15 Z9 15 U1 1 U2 5 PU ASPEN PUBL INC PI FREDERICK PA 7201 MCKINNEY CIRCLE, FREDERICK, MD 21701 SN 0161-9268 J9 ADV NURS SCI JI Adv. Nurs. Sci. PD DEC PY 1990 VL 13 IS 2 BP 11 EP 21 PG 11 WC Nursing SC Nursing GA EJ778 UT WOS:A1990EJ77800003 PM 2124787 ER PT J AU MARCUSSEKURA, CJ WOERNER, AM ZWEIG, M COURT, DL LEVIN, JG KLUTCH, M AF MARCUSSEKURA, CJ WOERNER, AM ZWEIG, M COURT, DL LEVIN, JG KLUTCH, M TI EXPRESSION OF HIV-1 INTEGRASE IN ESCHERICHIA-COLI - IMMUNOLOGICAL ANALYSIS OF THE RECOMBINANT PROTEIN SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; RETROVIRUSES HTLV-III; MURINE LEUKEMIA-VIRUS; DNA-BINDING PROTEIN; POL GENE-PRODUCTS; ESCHERICHIA-COLI; REVERSE-TRANSCRIPTASE; FUSION PROTEINS; AVIAN-SARCOMA; MONOCLONAL-ANTIBODIES AB Sequences encoding the human immunodeficiency virus type 1 (HIV-1) integrase gene have been cloned and expressed in Escherichia coli. The expressed protein is a lambda-cII fusion protein of 37 kD containing the carboxyl-terminal 27 amino acids of reverse transcriptase fused to the entire integrase sequence and is insoluble, a feature which allows partial purification away from soluble bacterial proteins. As judged by its reactivity with HIV positive sera in Western blot and in enzyme-linked immunosorbent assay (ELISA), the recombinant integrase retains antigenicity similar to native protein. Additionally, ELISA data obtained with the cloned protein indicate that patients infected with HIV-1 who are at different stages of progression to AIDS have antibodies reactive with the cloned integrase. HIV-2 positive human sera are also reactive with the cloned integrase. Rabbit antibodies produced against the recombinant protein react both by ELISA and Western blot with the homologous bacterially expressed protein, recognize both virion HIV-1 integrase and reverse transcriptase in Western blots, and immunoprecipitate an HIV-1 virion protein of 34 kD. Unlike human antisera from patients infected with HIV-1 or HIV-2 which are frequently reactive with both HIV-1 and HIV-2 integrase, the rabbit antibodies are type specific, reacting with HIV-1, but not with HIV-2 integrase by Western blot. C1 PROGRAM RESOURCES INC,FREDERICK,MD. NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21701. NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. RP MARCUSSEKURA, CJ (reprint author), CTR BIOL EVALUAT & RES,DIV VIROL,BETHESDA,MD 20892, USA. NR 49 TC 10 Z9 10 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 1990 VL 6 IS 12 BP 1399 EP 1408 DI 10.1089/aid.1990.6.1399 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ET189 UT WOS:A1990ET18900006 PM 2078417 ER PT J AU CAUSSY, D WEISS, SH BLATTNER, WA FRENCH, J CANTOR, KP GINZBURG, H ALTMAN, R GOEDERT, JJ AF CAUSSY, D WEISS, SH BLATTNER, WA FRENCH, J CANTOR, KP GINZBURG, H ALTMAN, R GOEDERT, JJ TI EXPOSURE FACTORS FOR HIV-1 INFECTION AMONG HETEROSEXUAL DRUG-ABUSERS IN NEW-JERSEY TREATMENT PROGRAMS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; NEW-YORK-CITY; UNITED-STATES; HTLV-III; RISK-FACTORS; SAN-FRANCISCO; USERS; AIDS; TRANSMISSION; ANTIBODIES AB In a cross-sectional study of 926 subjects from 10 drug treatment programs conducted in 1984 in New Jersey, the seroprevalence of human immunodeficiency virus (HIV) was 35% overall; 30% in whites, 33% in hispanics, and 46% in blacks (p = 0.01 for comparison of blacks to non-blacks). Univariate analysis showed the seroprevalence of HIV was not associated with age or gender, but did correlate with frequency of cocaine or heroin injection (p trend < 0.001); frequency of needle sharing (p trend = 0.007); and inversely with levels of education (p = 0.05). The prevalence of HIV was also inversely related to the distance of the treatment center from lower Manhattan; being highest for distances of less than 5 miles from lower Manhattan and lowest for distances of 80 miles, with intermediate rates for the intervening distances (p trend < 0.001). In multivariate analyses, HIV seropositivity was consistently associated with the frequency of needle sharing (p = 0.02) and less than 12 years (high school level) of education (p = 0.02), but not with black race. However, blacks who shared needles less than once a month had a relative risk of 3.2 (95% CI 1.2, 7.7) while non-blacks who shared less than once a month had a relative risk of only 0.9 (95% CI 0.3,2.4). The risk in non-blacks increased to more than twofold with more frequent needle sharing. When the analysis was stratified by gender and adjusted for needle sharing and geography, a significant twofold increased risk was observed for female (but not male) subjects who had two or more heterosexual partners compared with those who had one partner. These findings confirm that HIV infection is strongly associated with needle sharing within geographically and racially defined communities, as well as the additional risk that females in these communities experience through unprotected sexual intercourse with more than one partner. C1 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT PREVENT MED & COMMUNITY HLTH,NEWARK,NJ 07107. NCI,ENVIRONM EPIDEMIOL BRANCH,ROCKVILLE,MD. NEW JERSEY DEPT HLTH,TRENTON,NJ. HLTH RESOURCES SERV ADM,ROCKVILLE,MD. FU NCI NIH HHS [N01-CP-31041-03] NR 41 TC 28 Z9 28 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 1990 VL 6 IS 12 BP 1459 EP 1467 DI 10.1089/aid.1990.6.1459 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ET189 UT WOS:A1990ET18900014 PM 1964060 ER PT J AU KALINER, MA AF KALINER, MA TI INHALED CORTICOSTEROIDS FOR CHRONIC ASTHMA SO AMERICAN FAMILY PHYSICIAN LA English DT Article RP KALINER, MA (reprint author), NIAID,ALLERG DIS SECT,BETHESDA,MD 20892, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD DEC PY 1990 VL 42 IS 6 BP 1609 EP 1616 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EL698 UT WOS:A1990EL69800014 ER PT J AU BRABHAM, KR ROBERTS, WC AF BRABHAM, KR ROBERTS, WC TI FATAL INTRAPERICARDIAL RUPTURE OF SINUS OF VALSALVA ANEURYSM SO AMERICAN HEART JOURNAL LA English DT Note C1 NHLBI,PATHOL BRANCH,BLDG 10,ROOM 2N258,BETHESDA,MD 20892. NR 2 TC 9 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD DEC PY 1990 VL 120 IS 6 BP 1455 EP 1456 DI 10.1016/0002-8703(90)90265-Y PN 1 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EL979 UT WOS:A1990EL97900032 PM 2248194 ER PT J AU KRAGEL, AH LAPA, JA ROBERTS, WC AF KRAGEL, AH LAPA, JA ROBERTS, WC TI CARDIOVASCULAR FINDINGS IN ALKAPTONURIC OCHRONOSIS SO AMERICAN HEART JOURNAL LA English DT Note C1 NHLBI, PATHOL BRANCH,BLDG 10,ROOM 2N258, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA. NATL NAVAL MED CTR, DEPT LAB MED, BETHESDA, MD 20814 USA. NR 12 TC 13 Z9 13 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD DEC PY 1990 VL 120 IS 6 BP 1460 EP 1463 DI 10.1016/0002-8703(90)90268-3 PN 1 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EL979 UT WOS:A1990EL97900035 PM 2248197 ER PT J AU ANTECOL, DH ROBERTS, WC AF ANTECOL, DH ROBERTS, WC TI SUDDEN-DEATH BEHIND THE WHEEL FROM NATURAL DISEASE IN DRIVERS OF 4-WHEELED MOTORIZED VEHICLES SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article C1 NHLBI,PATHOL BRANCH,BLDG 10,ROOM 2N258,BETHESDA,MD 20892. NR 14 TC 24 Z9 24 U1 1 U2 2 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD DEC 1 PY 1990 VL 66 IS 19 BP 1329 EP 1335 DI 10.1016/0002-9149(90)91163-Z PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EK567 UT WOS:A1990EK56700011 PM 2244563 ER PT J AU GERTZ, SD ROBERTS, WC AF GERTZ, SD ROBERTS, WC TI HEMODYNAMIC SHEAR FORCE IN RUPTURE OF CORONARY ARTERIAL ATHEROSCLEROTIC PLAQUES SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Editorial Material C1 HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT ANAT & EMBRYOL,IL-91010 JERUSALEM,ISRAEL. RP GERTZ, SD (reprint author), NHLBI,PATHOL BRANCH,BLDG 10,ROOM 2N258,BETHESDA,MD 20892, USA. NR 51 TC 162 Z9 171 U1 2 U2 2 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD DEC 1 PY 1990 VL 66 IS 19 BP 1368 EP 1372 DI 10.1016/0002-9149(90)91170-B PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EK567 UT WOS:A1990EK56700018 PM 2244569 ER PT J AU ROBERTS, WC KRAGEL, AH POTKIN, BN AF ROBERTS, WC KRAGEL, AH POTKIN, BN TI AGES AT DEATH AND SEX DISTRIBUTION IN AGE DECADE IN FATAL CORONARY-ARTERY DISEASE SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Note RP ROBERTS, WC (reprint author), NHLBI,PATHOL BRANCH,BETHESDA,MD 20892, USA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD DEC 1 PY 1990 VL 66 IS 19 BP 1379 EP 1381 DI 10.1016/0002-9149(90)91174-5 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EK567 UT WOS:A1990EK56700022 PM 2244573 ER PT J AU GAFFEY, MJ MILLS, SE MEDEIROS, LJ WEISS, LM AF GAFFEY, MJ MILLS, SE MEDEIROS, LJ WEISS, LM TI UNUSUAL VARIANTS OF ADRENAL PSEUDOCYSTS WITH INTRACYSTIC FAT, MYELOLIPOMATOUS METAPLASIA, AND METASTATIC CARCINOMA SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article C1 CITY HOPE NATL MED CTR,DEPT PATHOL,DIV SURG PATHOL,DUARTE,CA 91010. UNIV VIRGINIA,HLTH SCI CTR,DEPT PATHOL,DIV SURG PATHOL,CHARLOTTESVILLE,VA 22903. NCI,DEPT PATHOL,DIV SURG PATHOL,BETHESDA,MD 20892. NR 32 TC 19 Z9 20 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD DEC PY 1990 VL 94 IS 6 BP 706 EP 713 PG 8 WC Pathology SC Pathology GA EL129 UT WOS:A1990EL12900006 PM 2173883 ER PT J AU SUBAR, AF BLOCK, G AF SUBAR, AF BLOCK, G TI USE OF VITAMIN AND MINERAL SUPPLEMENTS - DEMOGRAPHICS AND AMOUNTS OF NUTRIENTS CONSUMED - THE 1987 HEALTH INTERVIEW SURVEY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article RP SUBAR, AF (reprint author), NCI,DIV CANC PREVENT & CONTROL,9000 ROCKVILLE PIKE,EPN 313,BETHESDA,MD 20892, USA. RI Block, Gladys/E-3304-2010 NR 27 TC 157 Z9 161 U1 0 U2 2 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC PY 1990 VL 132 IS 6 BP 1091 EP 1101 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EN620 UT WOS:A1990EN62000009 PM 2260541 ER PT J AU LEE, ET WELTY, TK FABSITZ, R COWAN, LD LE, NA OOPIK, AJ CUCCHIARA, AJ SAVAGE, PJ HOWARD, BV AF LEE, ET WELTY, TK FABSITZ, R COWAN, LD LE, NA OOPIK, AJ CUCCHIARA, AJ SAVAGE, PJ HOWARD, BV TI THE STRONG HEART-STUDY - A STUDY OF CARDIOVASCULAR-DISEASE IN AMERICAN-INDIANS - DESIGN AND METHODS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article C1 NHLBI,BETHESDA,MD 20892. MEDLANT RES FDN,WASHINGTON,DC. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. US PHS INDIAN HOSP,RAPID CITY,SD. RP LEE, ET (reprint author), UNIV OKLAHOMA,HLTH SCI CTR,DEPT BIOSTAT & EPIDEMIOL,POB 26901,OKLAHOMA CITY,OK 73190, USA. OI Le, Ngoc-Anh/0000-0002-2634-4798 NR 31 TC 348 Z9 350 U1 0 U2 1 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC PY 1990 VL 132 IS 6 BP 1141 EP 1155 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EN620 UT WOS:A1990EN62000014 PM 2260546 ER PT J AU GOLDSTEIN, AM FALK, RT HODGE, SE AF GOLDSTEIN, AM FALK, RT HODGE, SE TI A PROBLEM IN IDENTIFYING RISK-FACTORS FOR DISEASE USING SURROGATE EXPOSURE VARIABLES THAT ARE UNDER GENETIC-CONTROL SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article C1 NCI,ENVIRONM EPIDEMIOL BRANCH,POPULAT STUDIES SECT,BETHESDA,MD 20892. COLUMBIA UNIV,NEW YORK STATE PSYCHIAT INST,DEPT PSYCHIAT,NEW YORK,NY 10027. COLUMBIA UNIV,NEW YORK STATE PSYCHIAT INST,DEPT BIOSTAT,NEW YORK,NY 10027. RP GOLDSTEIN, AM (reprint author), NCI,ENVIRONM EPIDEMIOL BRANCH,FAMILY STUDIES SECT,EXECUT PLAZA N,ROOM 439,BETHESDA,MD 20892, USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC PY 1990 VL 132 IS 6 BP 1171 EP 1175 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EN620 UT WOS:A1990EN62000017 PM 2260549 ER PT J AU FREEDMAN, LS SCHATZKIN, A WAX, Y AF FREEDMAN, LS SCHATZKIN, A WAX, Y TI THE IMPACT OF DIETARY MEASUREMENT ERROR ON PLANNING SAMPLE-SIZE REQUIRED IN A COHORT STUDY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article C1 NCI,DIV CANC PREVENT & CONTROL,CANC PREVENT STUDIES BRANCH,BETHESDA,MD 20892. RP FREEDMAN, LS (reprint author), NCI,DIV CANC PREVENT & CONTROL,BIOMETRY BRANCH,EXECUT PLAZA N,BETHESDA,MD 20892, USA. NR 19 TC 51 Z9 51 U1 2 U2 3 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC PY 1990 VL 132 IS 6 BP 1185 EP 1195 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EN620 UT WOS:A1990EN62000019 PM 2135637 ER PT J AU HANIOKA, N KIMURA, S MEYER, UA GONZALEZ, FJ AF HANIOKA, N KIMURA, S MEYER, UA GONZALEZ, FJ TI THE HUMAN CYP2D LOCUS ASSOCIATED WITH A COMMON GENETIC-DEFECT IN DRUG OXIDATION - A G1934-]A BASE CHANGE IN INTRON-3 OF A MUTANT CYP2D6 ALLELE RESULTS IN AN ABERRANT-3' SPLICE RECOGNITION SITE SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article C1 NCI,MOLEC CARCINOGENESIS LAB,BLDG 37,RM 3E24,BETHESDA,MD 20892. UNIV BASEL,BIOCTR,DEPT PHARMACOL,CH-4056 BASEL,SWITZERLAND. NR 17 TC 136 Z9 142 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD DEC PY 1990 VL 47 IS 6 BP 994 EP 1001 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA EK400 UT WOS:A1990EK40000017 PM 1978565 ER PT J AU SELTZER, MH PLATO, CC FOX, KM AF SELTZER, MH PLATO, CC FOX, KM TI DERMATOGLYPHICS IN THE IDENTIFICATION OF WOMEN EITHER WITH OR AT RISK FOR BREAST-CANCER SO AMERICAN JOURNAL OF MEDICAL GENETICS LA English DT Article C1 UNIV MED & DENT NEW JERSEY,NEW JERSEY COLL MED,NEWARK,NJ 07103. NIA,GERONTOL RES CTR,BALTIMORE,MD 21224. RP SELTZER, MH (reprint author), ST BARNABAS HOSP,22 OLD SHORT HILLS RD,LIVINGSTON,NJ 07039, USA. NR 26 TC 7 Z9 11 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-7299 J9 AM J MED GENET JI Am. J. Med. Genet. PD DEC PY 1990 VL 37 IS 4 BP 482 EP 488 DI 10.1002/ajmg.1320370412 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA EH699 UT WOS:A1990EH69900011 PM 2260593 ER PT J AU POLIS, MA MASUR, H AF POLIS, MA MASUR, H TI PREDICTING THE PROGRESSION TO AIDS SO AMERICAN JOURNAL OF MEDICINE LA English DT Editorial Material RP POLIS, MA (reprint author), NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT CRIT CARE MED,BLDG 10,BETHESDA,MD 20892, USA. OI Polis, Michael/0000-0002-9151-2268 NR 40 TC 34 Z9 35 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD DEC PY 1990 VL 89 IS 6 BP 701 EP 705 DI 10.1016/0002-9343(90)90209-V PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EL693 UT WOS:A1990EL69300001 PM 1979204 ER PT J AU CASTRONOVO, V COLIN, C CLAYSMITH, AP CHEN, PHS LIFRANGE, E LAMBOTTE, R KRUTZSCH, H LIOTTA, LA SOBEL, ME AF CASTRONOVO, V COLIN, C CLAYSMITH, AP CHEN, PHS LIFRANGE, E LAMBOTTE, R KRUTZSCH, H LIOTTA, LA SOBEL, ME TI IMMUNODETECTION OF THE METASTASIS-ASSOCIATED LAMININ RECEPTOR IN HUMAN BREAST-CANCER CELLS OBTAINED BY FINE-NEEDLE ASPIRATION BIOPSY SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID CARCINOMA-CELLS; SARCOMA-CELLS; EXPRESSION; FIBRONECTIN; ADHESION; ANTIBODY; ESTROGEN AB Fine-needle aspiration biopsy of the breast is a very useful technique for the evaluation of a suspect lesion before surgical removal. Increased expression of the 67-kd laminin receptor has been associated with the metastatic phenotype of cancer cells, particularly in colon and breast cancers. In this study, the expression of laminin receptor was evaluated using the immunoperoxidase technique in 81 breast aspirates (26 benign and 55 neoplastic lesions). Cells obtained from benign samples exhibited a low level of laminin receptor antigen detected by affinity-purified antibody raised against a cDNA-derived laminin receptor peptide. In contrast, 71% of smears obtained from malignant breast lesions contained cells that were strongly stained by the antibody. Heterogeneous expression of the laminin receptor was noted in both breast aspirates and fixed tissue specimens. These data suggest that the immunodetection of laminin receptor in cells obtained by fine-needle aspiration of breast lesions could be a valuable adjunct in the prognostic evaluation of breast lesions. C1 STATE UNIV LIEGE,DEPT GYNAECOL OBSTET,B-4000 LIEGE,BELGIUM. RP CASTRONOVO, V (reprint author), NCI,PATHOL LAB,TUMOR INVAS & METASTASIS SECT,BLDG 10,ROOM 2A33,BETHESDA,MD 20892, USA. NR 28 TC 69 Z9 70 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD DEC PY 1990 VL 137 IS 6 BP 1373 EP 1381 PG 9 WC Pathology SC Pathology GA EP243 UT WOS:A1990EP24300013 PM 2148054 ER PT J AU FRICKHOFEN, N LIU, JM YOUNG, NS AF FRICKHOFEN, N LIU, JM YOUNG, NS TI ETIOLOGIC MECHANISMS OF HEMATOPOIETIC FAILURE SO AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article C1 NHLBI,CLIN HEMATOL BRANCH,BLDG 10,ROOM 7C103,BETHESDA,MD 20892. NR 112 TC 22 Z9 22 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-8562 J9 AM J PEDIAT HEMATOL PD WIN PY 1990 VL 12 IS 4 BP 385 EP 395 PG 11 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA EL131 UT WOS:A1990EL13100002 PM 2285119 ER PT J AU ABBONDANZO, SL MEDEIROS, LJ COSSMAN, J AF ABBONDANZO, SL MEDEIROS, LJ COSSMAN, J TI MOLECULAR-GENETICS AND ITS APPLICATION TO THE DIAGNOSIS AND CLASSIFICATION OF HEMATOPOIETIC NEOPLASMS SO AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article C1 NCI,PATHOL LAB,BLDG 10,ROOM 2N113,BETHESDA,MD 20892. NR 90 TC 8 Z9 8 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-8562 J9 AM J PEDIAT HEMATOL PD WIN PY 1990 VL 12 IS 4 BP 480 EP 489 PG 10 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA EL131 UT WOS:A1990EL13100014 PM 2285131 ER PT J AU BARRIGA, FJ AF BARRIGA, FJ TI DEVELOPMENT OF PEDIATRIC ONCOLOGY IN SOUTH-AMERICA - CHALLENGES AND PERSPECTIVES SO AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article C1 NCI,PEDIAT ONCOL,BETHESDA,MD. RP BARRIGA, FJ (reprint author), CATHOLIC UNIV CHILE,DEPT PEDIAT,POB 114-D,SANTIAGO,CHILE. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-8562 J9 AM J PEDIAT HEMATOL PD WIN PY 1990 VL 12 IS 4 BP 510 EP 512 PG 3 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA EL131 UT WOS:A1990EL13100018 PM 2285133 ER PT J AU ANDERSON, SE MURPHY, E STEENBERGEN, C LONDON, RE CALA, PM AF ANDERSON, SE MURPHY, E STEENBERGEN, C LONDON, RE CALA, PM TI NA-H EXCHANGE IN MYOCARDIUM - EFFECTS OF HYPOXIA AND ACIDIFICATION ON NA AND CA SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE AMILORIDE; SODIUM-POTASSIUM-ADENOSINE-TRIPHOSPHATASE; LANGENDORFF-PERFUSED RABBIT HEARTS ID CHICK HEART-CELLS; RED-BLOOD-CELLS; VOLUME REGULATION; RABBIT HEARTS; SHIFT-REAGENT; FREE-RADICALS; RAT HEARTS; SODIUM; ISCHEMIA; CALCIUM AB Historically, increases in cell Na content during ischemic and hypoxic episodes were thought to result from impaired ATP production causing decreased Na+ -K+ -ATPase activty. Here we report the results of testing the alternate hypothesis that hypoxia-induced Na uptake is 1) the result of increased entry, as opposed to decreased extrusion 2) via Na-H exchange operating in a pH regulatory capacity and that cell Ca accumulation occurs via Na-Ca exchange secondary to collapse of the Na gradient. We used Na-23-,F-19-, and P-31- nuclear magnetic resonance (NMR) to measure intracellular Na content (Na(i)), Ca concentration (]Ca[i), pH (pH(i)), and high-energy phosphates in Langendorff-perfused rabbit hearts. When the Na+ -K+ -ATPase was inhibited by ouabain and/or K-free perfusion, hearts subjected to hypoxia gained Na at a rate > 10 times that of normoxic controls [during the first 12.5 min Na(i) increased from 7.9 +/- 5.8 to 34.9 +/- 11.0 (SD) meq/kg dry wt compared with 11.1 +/- 16.3 to 13.6 +/- 9.0 meq/kg dry wt, respectively]. When normoxic hearts were acidified using a 20 mM NH4Cl prepulse technique, pH(i) rapidly fell from 7.27 +/- 0.24 to 6.63 +/- 0.12 but returned to 7.07 +/- 0.10 within 20 min, while Na uptake was similar in rate and magnitude to that observed during hypoxia (24.5 +/- 13.4 to 132.1 +/- 17.7 meq/kg dry wt). During hypoxia and after NH4Cl washout, increases in [Ca]i were similar in time course to those observed for Na(i). Increases in Na(i) were insensitive to benzamil (50-mu-M) and bumetanide (10-mu-M), whereas increases in Na(i) as well as pH(i) regulation (ager NH4Cl washout) and increases in [Ca]i were inhibited by amiloride (1 mM) and 5-(N-ethyl-N-isopropyl) amiloride (EIPA, 100-mu-M). EIPA and amiloride also decreased changes in coronary resistance and phosphocreatine measured after 60 min of hypoxic perfusion (P < 0.05). These results are consistent with our hypothesis. C1 NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709. DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710. RP ANDERSON, SE (reprint author), UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL,DAVIS,CA 95616, USA. FU NCRR NIH HHS [RR-02479]; NHLBI NIH HHS [R01 HL039752, HL-21179] NR 39 TC 155 Z9 157 U1 2 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP C940 EP C948 PN 1 PG 9 WC Physiology SC Physiology GA EQ382 UT WOS:A1990EQ38200013 PM 2175547 ER PT J AU FLAMION, B SPRING, KR AF FLAMION, B SPRING, KR TI WATER PERMEABILITY OF APICAL AND BASOLATERAL CELL-MEMBRANES OF RAT INNER MEDULLARY COLLECTING DUCT SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE DIFFERENTIAL INTERFERENCE CONTRAST MICROSCOPY; ISOLATED PERFUSED TUBULE; ANTIDIURETIC HORMONE; CELL VOLUME; VOLUME REGULATORY DECREASE; VOLUME REGULATORY INCREASE ID QUANTITATIVE-ANALYSIS; VOLUME REGULATION; RABBIT KIDNEY; DISTAL TUBULE; TRANSPORT; VASOPRESSIN; UREA; REABSORPTION; PST AB To quantify the pathways for water permeation through the kidney medulla, knowledge of the water permeability (P(osmol)) of individual cell membranes in inner medullary collecting duct (IMCD) is required. Therefore IMCD segments from the inner two thirds of inner medulla of Sprague-Dawley rats were perfused in vitro using a setup devised for rapid bath and luminal fluid exchanges (half time, t1/2 of 55 and 41 ms). Differential interference contrast microscopy, coupled to video recording, was used to measure volume and approximate surface areas of single cells. Volume and volume-to-surface area ratio of IMCD cells were strongly correlated with their position along the inner medullary axis. Transmembrane water flow (J(v)) was measured in response to a variety of osmotic gradient (DELTA-II) presented on either basolateral or luminal side of the cells. The linear relation between J(v) and DELTA-II yielded the cell membrane P(osmol), which was then corrected for membrane in foldings. Basolateral membrane P(osmol) was 126 +/- 3-mu-m/s. Apical membrane P(osmol) rose from a basal value of 26 +/- 3-mu-m/s to 99 +/- 5-mu-m/s in presence of antidiuretic hormone (ADH). Because of amplification of basolateral membrane, the ADH-stimulated apical membrane remained rate-limiting for transcellular osmotic water flow, and the IMCD cell did not swell significantly. Calculated transcellular P(osmol), expressed in terms of smooth luminal surface, was 64-mu-m/s without ADH and 207-mu-m/s with ADH. IMCD cells in anisosmotic media displayed almost complete volume regulatory decrease but only partial volume regulatory increase. RP FLAMION, B (reprint author), NHLBI,KIDNEY & ELECTROLYTE METAB LAB,BLDG 10,RM 6N307,BETHESDA,MD 20892, USA. NR 37 TC 56 Z9 57 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP F986 EP F999 PN 2 PG 14 WC Physiology SC Physiology GA EQ387 UT WOS:A1990EQ38700091 PM 2260688 ER PT J AU WRIGHT, PA KNEPPER, MA AF WRIGHT, PA KNEPPER, MA TI PHOSPHATE-DEPENDENT GLUTAMINASE ACTIVITY IN RAT RENAL CORTICAL AND MEDULLARY TUBULE SEGMENTS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE AMMONIUM; GLUTAMINE; GLUTAMATE; PROXIMAL TUBULES; INNER MEDULLARY COLLECTING DUCT; OUTER MEDULLARY COLLECTING DUCT; DISTAL CONVOLUTED TUBULES; THIN LIMBS ID CHRONIC METABOLIC-ACIDOSIS; AMMONIA PRODUCTION; INNER MEDULLA; NEPHRON SEGMENTS; COLLECTING DUCT; INHIBITION AB To determine whether local production of ammonium by medullary renal tubule segments may contribute to medullary ammonium accumulation, we measured activities of phosphate-dependent glutaminase (PDG) in microdissected tubule segments form rat medulla and cortex. PDG activities were very low in medullary loop of henle segments but surprisingly high in inner medullary collecting duct (IMCD). In cortex, PDG levels were highest in distal convoluted tubule and cortical thick ascending limb, but substantial levels were also found in proximal segments, as reported previously. To determine effects of acid loading and alkali loading of PDG activity, 0.28 M NH4Cl (acid) or 0.28 M NaHCO3 (alkali) was added to rats' drinking water for 7 days. PDG activities in medullary segments were not affected by acid or alkali intake. Acid intake by rats increased PDG activity in S1 and S2 proximal convoluted tubules severalfold but did not affect the other cortical segments. We conclude that medullary loop of Henle segments probably contribute relatively little to medullary ammonium accumulation because of their low activities. The high PDG activity in IMCD suggests that ammonium could be produced and secreted by this segment. However, because total tubule length of IMCD is very low compared with proximal tubules, it appears unlikely that IMCD contributes substantially to overall renal ammonium production. PDG activity is regulated only in S1 and S2 proximal tubules, consistent with the view that the proximal tubule is the major site of regulation of renal ammonium production. C1 NIH,KIDNEY & ELECTROLYTE METAB LAB,BLDG 10,RM 6N307,BETHESDA,MD 20892. NR 30 TC 42 Z9 42 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP F961 EP F970 PN 2 PG 10 WC Physiology SC Physiology GA EQ387 UT WOS:A1990EQ38700088 PM 2175563 ER PT J AU MAIXNER, W GRACELY, RH ZUNIGA, JR HUMPHREY, CB BLOODWORTH, GR AF MAIXNER, W GRACELY, RH ZUNIGA, JR HUMPHREY, CB BLOODWORTH, GR TI CARDIOVASCULAR AND SENSORY RESPONSES TO FOREARM ISCHEMIA AND DYNAMIC HAND EXERCISE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PAIN; EXERCISE; ADAPTIVE MECHANISMS; BLOOD PRESSURE; REFLEXES; PSYCHOPHYSICS ID RESPIRATORY RESPONSES; CENTRAL COMMAND; HEART-RATE; REFLEXES; MUSCLE; PAIN; COMPONENTS; AFFERENT; HUMANS; CATS AB The relationship between cardiovascular responses and pain produced by the submaximal-effort tourniquet procedure was evaluated in healthy humans. Graded increases in ischemic pain were associated with graded elevations in arterial blood pressure, forearm vascular resistance, and venous tone. Many of the vascular responses to muscle ischemia were typical of the cardiovascular components of the defense reaction and correlated with both the sensory and affective aspects of ischemic pain. The cardiovascular responses to arm ischemia were distinguishable from those produced by rhythmic hand exercise used to produce ischemia. Dynamic hand exercise produced a transient increase in arterial blood pressure, heart rate, and measures of hand discomfort. These responses were enhanced when dynamic hand exercise was conducted under ischemic conditions. The tightly coupled and coordinated cardiovascular responses elicited by ischemic pain represent integrated adaptive responses to painful stimulation. C1 UNIV N CAROLINA,DEPT PHARMACOL,CHAPEL HILL,NC 27599. NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BETHESDA,MD 20892. RP MAIXNER, W (reprint author), UNIV N CAROLINA,DENT RES CTR,RM 03,CHAPEL HILL,NC 27599, USA. NR 32 TC 57 Z9 57 U1 2 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP R1156 EP R1163 PN 2 PG 8 WC Physiology SC Physiology GA EQ387 UT WOS:A1990EQ38700056 ER PT J AU CORYELL, W ENDICOTT, J KELLER, M AF CORYELL, W ENDICOTT, J KELLER, M TI OUTCOME OF PATIENTS WITH CHRONIC AFFECTIVE-DISORDER - A 5-YEAR FOLLOW-UP SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article C1 NIMH,COLLABORAT PROGRAM PSYCHOBIOL DEPRESS CLIN STUDIES,WASHINGTON,DC 20032. RP CORYELL, W (reprint author), UNIV IOWA,COLL MED,DEPT PSYCHIAT,500 NEWTON RD,IOWA CITY,IA 52242, USA. FU NIMH NIH HHS [R01 MH025478] NR 23 TC 113 Z9 114 U1 1 U2 3 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD DEC PY 1990 VL 147 IS 12 BP 1627 EP 1633 PG 7 WC Psychiatry SC Psychiatry GA EK703 UT WOS:A1990EK70300007 PM 2244640 ER PT J AU HAYNES, SG HARVEY, C MONTES, H NICKENS, H COHEN, BH AF HAYNES, SG HARVEY, C MONTES, H NICKENS, H COHEN, BH TI PATTERNS OF CIGARETTE-SMOKING AMONG HISPANICS IN THE UNITED-STATES - RESULTS FROM HHANES 1982-84 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article C1 NCI,SMOKING TOBACCO & CANC PROGRAM,BETHESDA,MD 20892. HENRY J KAISER FAMILY FDN,MENLO PK,CA. ASSOC AMER MED COLL,WASHINGTON,DC 20036. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21218. RP HAYNES, SG (reprint author), NCI,HLTH PROMOT SCI BRANCH,BETHESDA,MD 20892, USA. NR 37 TC 119 Z9 119 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 1990 VL 80 SU S BP 47 EP 53 DI 10.2105/AJPH.80.Suppl.47 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EL501 UT WOS:A1990EL50100009 PM 9187582 ER PT J AU PATTERSON, BH BLOCK, G ROSENBERGER, WF PEE, D KAHLE, LL AF PATTERSON, BH BLOCK, G ROSENBERGER, WF PEE, D KAHLE, LL TI FRUIT AND VEGETABLES IN THE AMERICAN DIET - DATA FROM THE NHANES-II SURVEY SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article C1 INFORMAT MANAGEMENT SERV INC,SILVER SPRING,MD. RP PATTERSON, BH (reprint author), NCI,DIV CANC PREVENT & CONTROL,BIOMETRY BRANCH,BETHESDA,MD 20892, USA. RI Block, Gladys/E-3304-2010 NR 27 TC 191 Z9 194 U1 0 U2 4 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 1990 VL 80 IS 12 BP 1443 EP 1449 DI 10.2105/AJPH.80.12.1443 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EJ980 UT WOS:A1990EJ98000005 PM 2240327 ER PT J AU SOLOMON, RE VANRADEN, M KASLOW, RA LYTER, D VISSCHER, B FARZADEGAN, H PHAIR, J AF SOLOMON, RE VANRADEN, M KASLOW, RA LYTER, D VISSCHER, B FARZADEGAN, H PHAIR, J TI ASSOCIATION OF HEPATITIS-B SURFACE-ANTIGEN AND CORE ANTIBODY WITH ACQUISITION AND MANIFESTATIONS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) INFECTION SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article C1 NIAID,DMID,EPIDEMIOL & BIOMETRY BRANCH,WESTWOOD 739,BETHESDA,MD 20892. UNIV PITTSBURGH,GRAD SCH PUBL HLTH,PITTSBURGH,PA 15260. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21218. UNIV CALIF LOS ANGELES,DEPT EPIDEMIOL,LOS ANGELES,CA 90024. NORTHWESTERN UNIV,SCH MED,DEPT MED,HOWARD BROWN MEM CLIN,CHICAGO,IL 60611. FU NIAID NIH HHS [AI-32520, AI-32513, AI-32511] NR 21 TC 46 Z9 46 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 1990 VL 80 IS 12 BP 1475 EP 1478 DI 10.2105/AJPH.80.12.1475 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EJ980 UT WOS:A1990EJ98000012 PM 2240333 ER PT J AU GRIDLEY, G MCLAUGHLIN, JK BLOT, WJ AF GRIDLEY, G MCLAUGHLIN, JK BLOT, WJ TI DIETARY VITAMIN-C INTAKE AND CIGARETTE-SMOKING SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Letter RP GRIDLEY, G (reprint author), NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 1990 VL 80 IS 12 BP 1526 EP 1526 DI 10.2105/AJPH.80.12.1526 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EJ980 UT WOS:A1990EJ98000032 PM 2240352 ER PT J AU OSORNIOVARGAS, AR BONNER, JC BADGETT, A BRODY, AR AF OSORNIOVARGAS, AR BONNER, JC BADGETT, A BRODY, AR TI RAT ALVEOLAR MACROPHAGE DERIVED PLATELET-DERIVED GROWTH-FACTOR IS CHEMOTACTIC FOR RAT LUNG FIBROBLASTS SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article C1 NIEHS,PULM PATHOBIOL LAB,POB 12233,RES TRIANGLE PK,NC 27709. INST NACL CARDIOL,DEPT BIOQUIM,TLALPAN,MEXICO. RI Osornio Vargas, Alvaro/D-4012-2009; Osornio Vargas, Alvaro/B-4645-2010 OI Osornio Vargas, Alvaro/0000-0001-8287-7102 NR 30 TC 33 Z9 33 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1044-1549 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD DEC PY 1990 VL 3 IS 6 BP 595 EP 602 PG 8 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA EM677 UT WOS:A1990EM67700011 PM 1701306 ER PT J AU BLACK, WC DWYER, AJ AF BLACK, WC DWYER, AJ TI KNOWLEDGE OF CLINICAL HISTORY AND THE ACCURACY OF INTERPRETATION OF CHEST RADIOGRAPHS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter RP BLACK, WC (reprint author), NIH,WARREN G MAGNUSON CLIN CTR,BETHESDA,MD 20892, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 1990 VL 155 IS 6 BP 1342 EP 1342 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EK408 UT WOS:A1990EK40800037 PM 2122692 ER PT J AU TRAVIS, WD COLBY, TV LOMBARD, C CARPENTER, HA AF TRAVIS, WD COLBY, TV LOMBARD, C CARPENTER, HA TI A CLINICOPATHOLOGICAL STUDY OF 34 CASES OF DIFFUSE PULMONARY HEMORRHAGE WITH LUNG-BIOPSY CONFIRMATION SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article C1 EL CAMINO HOSP,DEPT PATHOL,MT VIEW,CA. MAYO CLIN & MAYO FDN,DEPT SURG PATHOL,ROCHESTER,MN 55905. RP TRAVIS, WD (reprint author), NCI,PATHOL LAB,BLDG 10,ROOM 2N212,BETHESDA,MD 20892, USA. NR 38 TC 160 Z9 165 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD DEC PY 1990 VL 14 IS 12 BP 1112 EP 1125 DI 10.1097/00000478-199012000-00003 PG 14 WC Pathology; Surgery SC Pathology; Surgery GA EM519 UT WOS:A1990EM51900003 PM 2252102 ER PT J AU AARONSON, SA RUBIN, JS FINCH, PW WONG, J MARCHESE, C FALCO, J TAYLOR, WG KRAUS, MH AF AARONSON, SA RUBIN, JS FINCH, PW WONG, J MARCHESE, C FALCO, J TAYLOR, WG KRAUS, MH TI GROWTH FACTOR-REGULATED PATHWAYS IN EPITHELIAL-CELL PROLIFERATION SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article C1 RHODE ISL HOSP,DEPT NEUROSURG,PROVIDENCE,RI 02902. HOWARD HUGHES MED INST,BETHESDA,MD. UNIV CATANIA,I-95124 CATANIA,ITALY. JOHNS HOPKINS UNIV HOSP,CTR ONCOL,BALTIMORE,MD 21205. RP AARONSON, SA (reprint author), NCI,CELLULAR & MOLEC BIOL LAB,BLDG 37,ROOM 1E24,BETHESDA,MD 20892, USA. NR 47 TC 39 Z9 40 U1 0 U2 3 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1990 VL 142 IS 6 SU S BP S7 EP S10 PG 4 WC Respiratory System SC Respiratory System GA EN295 UT WOS:A1990EN29500004 PM 2252277 ER PT J AU JETTEN, AM VOLLBERG, TM NERVI, C GEORGE, MD AF JETTEN, AM VOLLBERG, TM NERVI, C GEORGE, MD TI POSITIVE AND NEGATIVE REGULATION OF PROLIFERATION AND DIFFERENTIATION IN TRACHEOBRONCHIAL EPITHELIAL-CELLS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article RP JETTEN, AM (reprint author), NIEHS,CELL BIOL SECT,PULM PATHOBIOL LAB,RES TRIANGLE PK,NC 27709, USA. NR 29 TC 29 Z9 29 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1990 VL 142 IS 6 SU S BP S36 EP S39 PG 4 WC Respiratory System SC Respiratory System GA EN295 UT WOS:A1990EN29500010 PM 2252274 ER PT J AU KAYE, FJ KRATZKE, RA GERSTER, JL LIN, PS AF KAYE, FJ KRATZKE, RA GERSTER, JL LIN, PS TI RECESSIVE ONCOGENES IN LUNG-CANCER SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article C1 HOWARD HUGHES MED INST,NIH RES SCOLARS PROGRAM,BETHESDA,MD. UNIFORMED SERV UNIV HLTH SCI,NCI,NAVY MED ONCOL BRANCH,BETHESDA,MD. RI kaye, frederic/E-2437-2011 NR 48 TC 11 Z9 11 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1990 VL 142 IS 6 SU S BP S44 EP S47 PG 4 WC Respiratory System SC Respiratory System GA EN295 UT WOS:A1990EN29500012 PM 2174662 ER PT J AU MAX, MB AF MAX, MB TI IMPROVING OUTCOMES OF ANALGESIC TREATMENT - IS EDUCATION ENOUGH SO ANNALS OF INTERNAL MEDICINE LA English DT Article RP MAX, MB (reprint author), NIDR,BLDG 10,ROOM 3C-405,BETHESDA,MD 20892, USA. NR 57 TC 124 Z9 126 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 1 PY 1990 VL 113 IS 11 BP 885 EP 889 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EK558 UT WOS:A1990EK55800012 PM 2240903 ER PT J AU KREIS, W KAPLAN, MH FREEMAN, J SUN, DK SARIN, PS AF KREIS, W KAPLAN, MH FREEMAN, J SUN, DK SARIN, PS TI INHIBITION OF HIV REPLICATION BY HYSSOP-OFFICINALIS EXTRACTS SO ANTIVIRAL RESEARCH LA English DT Article DE HYSSOP-OFFICINALIS; CAFFEIC ACID; ANTI-HIV ACTIVITY ID HUMAN IMMUNODEFICIENCY VIRUS; CHRONICALLY INFECTED-CELLS; ANTISENSE OLIGODEOXYNUCLEOTIDES; INVITRO; 3'-AZIDO-3'-DEOXYTHYMIDINE; INFECTIVITY; FOSCARNET; ACID; AIDS; PHOSPHONOFORMATE AB Crude extracts of dried leaves of Hyssop officinalis showed strong anti-HIV activity as measured by inhibition of syncytia formation, HIV reverse transcriptase (RT), and p17 and p24 antigen expression, but were non-toxic to the uninfected Molt-3 cells. Ether extracts from direct extraction (Procedure I), after removal of tannins (Procedure II), or from the residue after dialysis of the crude extract (Procedure III), showed good antiviral activity. Methanol extracts, subsequent to ether, chloroform and chloroform ethanol extractions, derived from procedure I or II, but not III, also showed very strong anti-HIV activity. In addition, the residual material after methanol extractions still showed strong activity. Caffeic acid was identified in the ether extract of procedure I by HPLC and UV spectroscopy. Commercial caffeic acid showed good antiviral activity in the RT assay and high to moderate activity in the syncytia assay and the p17 and p24 antigen expression. Tannic acid and gallic acid, common to other teas, could not be identified in our extracts. When commercial products of these two acids were tested in our assay systems, they showed high to moderate activity against HIV-1. Hyssop officinalis extracts contain caffeic acid, unidentified tannins, and possibly a third class of unidentified higher molecular weight compounds that exhibit strong anti-HIV activity, and may be useful in the treatment of patients with AIDS. C1 CORNELL UNIV,COLL MED,MANHASSET,NY. NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. RP KREIS, W (reprint author), N SHORE UNIV HOSP,DEPT MED,300 COMMUNITY DR,MANHASSET,NY 11030, USA. NR 40 TC 32 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD DEC PY 1990 VL 14 IS 6 BP 323 EP 337 DI 10.1016/0166-3542(90)90051-8 PG 15 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA ER205 UT WOS:A1990ER20500002 PM 1708226 ER PT J AU KREIS, W KAPLAN, MH FREEMAN, J SUN, DK SARIN, PS AF KREIS, W KAPLAN, MH FREEMAN, J SUN, DK SARIN, PS TI INHIBITION OF HIV REPLICATION BY HYSSOP-OFFICINALIS EXTRACTS SO ANTIVIRAL RESEARCH LA English DT Article DE HYSSOP-OFFICINALIS; CAFFEIC ACID; ANTI-HIV ACTIVITY ID HUMAN IMMUNODEFICIENCY VIRUS; CHRONICALLY INFECTED-CELLS; ANTISENSE OLIGODEOXYNUCLEOTIDES; INVITRO; 3'-AZIDO-3'-DEOXYTHYMIDINE; INFECTIVITY; FOSCARNET; ACID; AIDS; PHOSPHONOFORMATE AB Crude extracts of dried leaves of Hyssop officinalis showed strong anti-HIV activity as measured by inhibition of synctia formation, HIV reverse transcriptase (RT), and p17 and p24 antigen expression, but were non-toxic to the uninfected Molt-3 cells. Ether extracts from direct extraction (Procedure I), after removal of tannins (Procedure II), or from the residue after dialysis of the crude extract (Procedure III), showed good antiviral activity. Methanol extracts, subsequent to ether, chloroform and chloroform ethanol extractions, derived from procedure I or II, but not III, also showed very strong anti-HIV activity. In addition, the residual material after methanol extractions still showed strong activity. Caffeic acid was identified in the ether extract of procedure I by HPLC and UV spectroscopy. Commercial caffeic acid showed good antiviral activity in the RT assay and high to moderate activity in the synctyia assay and the p17 and p24 antigen expression. Tannic acid and gallic acid, common to other teas, could not be identified in our extracts. When commercial products of these two acids were tested in our assay systems, they showed high to moderate activity against HIV-1. Hyssop officinalis extracts contain caffeic acid, unidentified tannins, and possibly a third class of unidentified higher molecular weight compounds that exhibit strong anti-HIV activity, and may be useful in the treatment of patients with AIDS. C1 CORNELL UNIV,COLL MED,MANHASSET,NY. NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. RP KREIS, W (reprint author), N SHORE UNIV HOSP,DEPT MED,300 COMMUNITY DR,MANHASSET,NY 11030, USA. NR 40 TC 32 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD DEC PY 1990 VL 14 IS 6 SU 2 BP 323 EP 337 DI 10.1016/0166-3542(90)90051-8 PG 15 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA EQ816 UT WOS:A1990EQ81600002 PM 1708226 ER PT J AU KOLENBRANDER, PE ANDERSEN, RN MOORE, LVH AF KOLENBRANDER, PE ANDERSEN, RN MOORE, LVH TI INTRAGENERIC COAGGREGATION AMONG STRAINS OF HUMAN ORAL BACTERIA - POTENTIAL ROLE IN PRIMARY COLONIZATION OF THE TOOTH SURFACE SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Note C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT ANAEROB MICROBIOL,BLACKSBURG,VA 24061. RP KOLENBRANDER, PE (reprint author), NIDR,MICROBIAL ECOL LAB,BETHESDA,MD 20892, USA. FU NIDCR NIH HHS [DE-08972, DE-05054, DE-05139] NR 32 TC 93 Z9 95 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 1990 VL 56 IS 12 BP 3890 EP 3894 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA EM073 UT WOS:A1990EM07300045 PM 2082831 ER PT J AU MOREHOUSE, KM MASON, RP AF MOREHOUSE, KM MASON, RP TI THE ENZYMATIC ONE-ELECTRON REDUCTION OF PORPHYRINS TO THEIR ANION FREE-RADICALS SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NIEHS,MOLEC BIOPHYS LAB,POB 12233,MD 10-03,RES TRIANGLE PK,NC 27709. NR 40 TC 7 Z9 7 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD DEC PY 1990 VL 283 IS 2 BP 306 EP 310 DI 10.1016/0003-9861(90)90647-H PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EN071 UT WOS:A1990EN07100013 PM 2177327 ER PT J AU IKEDASAITO, M KIMURA, S AF IKEDASAITO, M KIMURA, S TI AXIAL LIGAND COORDINATION IN INTESTINAL PEROXIDASE SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892. RP IKEDASAITO, M (reprint author), CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS,CLEVELAND,OH 44106, USA. RI Ikeda-Saito, Masao/A-5992-2008; Ikeda-Saito, Masao/K-2703-2015 FU NIGMS NIH HHS [GM39359, GM39492] NR 27 TC 5 Z9 5 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD DEC PY 1990 VL 283 IS 2 BP 351 EP 355 DI 10.1016/0003-9861(90)90653-G PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EN071 UT WOS:A1990EN07100019 PM 2177328 ER PT J AU OLAH, ME JACOBSON, KA STILES, GL AF OLAH, ME JACOBSON, KA STILES, GL TI PURIFICATION AND CHARACTERIZATION OF BOVINE CEREBRAL-CORTEX A1 ADENOSINE RECEPTOR SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NIDDKD,DEPT CHEM,BETHESDA,MD 20892. RP OLAH, ME (reprint author), DUKE UNIV,MED CTR,DEPT MED CARDIOL,BOX 3444,DURHAM,NC 27710, USA. RI Jacobson, Kenneth/A-1530-2009 OI Jacobson, Kenneth/0000-0001-8104-1493 FU Intramural NIH HHS [Z01 DK031117-20, Z99 DK999999]; NHLBI NIH HHS [R01-HL-35134]; NIGMS NIH HHS [1F32-GM-13713-01] NR 21 TC 27 Z9 27 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD DEC PY 1990 VL 283 IS 2 BP 440 EP 446 DI 10.1016/0003-9861(90)90665-L PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EN071 UT WOS:A1990EN07100031 PM 2275555 ER PT J AU KOZACHUK, WE DECARLI, C SCHAPIRO, MB WAGNER, EE RAPOPORT, SI HORWITZ, B AF KOZACHUK, WE DECARLI, C SCHAPIRO, MB WAGNER, EE RAPOPORT, SI HORWITZ, B TI WHITE MATTER HYPERINTENSITIES IN DEMENTIA OF ALZHEIMERS TYPE AND IN HEALTHY-SUBJECTS WITHOUT CEREBROVASCULAR RISK-FACTORS - A MAGNETIC-RESONANCE-IMAGING STUDY SO ARCHIVES OF NEUROLOGY LA English DT Article C1 NIA,NEUROSCI LAB,BLDG 10,ROOM 6C-414,BETHESDA,MD 20892. RI DeCarli, Charles/B-5541-2009 NR 41 TC 123 Z9 123 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD DEC PY 1990 VL 47 IS 12 BP 1306 EP 1310 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA EN301 UT WOS:A1990EN30100007 PM 2252447 ER PT J AU KAYE, JA GRADY, CL HAXBY, JV MOORE, A FRIEDLAND, RP AF KAYE, JA GRADY, CL HAXBY, JV MOORE, A FRIEDLAND, RP TI PLASTICITY IN THE AGING BRAIN - REVERSIBILITY OF ANATOMIC, METABOLIC, AND COGNITIVE DEFICITS IN NORMAL-PRESSURE HYDROCEPHALUS FOLLOWING SHUNT SURGERY SO ARCHIVES OF NEUROLOGY LA English DT Article C1 NIA,BRAIN AGING & DEMENTIA SECT,NEUROSCI LAB,BETHESDA,MD 20892. RI Friedland, Robert/A-2834-2010; OI Friedland, Robert/0000-0001-5721-1843; Kaye, Jeffrey/0000-0002-9971-3478 NR 36 TC 29 Z9 29 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD DEC PY 1990 VL 47 IS 12 BP 1336 EP 1341 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA EN301 UT WOS:A1990EN30100012 PM 2252451 ER PT J AU KERTZMAN, C ROBINSON, DL LITVAN, I AF KERTZMAN, C ROBINSON, DL LITVAN, I TI EFFECTS OF PHYSOSTIGMINE ON SPATIAL ATTENTION IN PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY SO ARCHIVES OF NEUROLOGY LA English DT Article C1 NEI,SENSORIMOTOR RES LAB,VISUAL BEHAV SECT,BLDG 10,ROOM 10C101,BETHESDA,MD 20892. NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892. OI Litvan, Irene/0000-0002-3485-3445 NR 43 TC 28 Z9 28 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD DEC PY 1990 VL 47 IS 12 BP 1346 EP 1350 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA EN301 UT WOS:A1990EN30100014 PM 2252453 ER PT J AU MERRITT, WD WEISSLER, MC TURK, BF GILMER, TM AF MERRITT, WD WEISSLER, MC TURK, BF GILMER, TM TI ONCOGENE AMPLIFICATION IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article C1 GLAXO RES LABS,DEPT CHEMOTHERAPY,5 MOORE DR,RES TRIANGLE PK,NC 27709. UNIV N CAROLINA,DIV OTOLARYNGOL HEAD & NECK SURG,CHAPEL HILL,NC 27514. NIEHS,MOLEC CARCINOGENESIS LAB,RES TRIANGLE PK,NC 27709. NR 48 TC 78 Z9 78 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD DEC PY 1990 VL 116 IS 12 BP 1394 EP 1398 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA EN334 UT WOS:A1990EN33400005 PM 2248738 ER PT J AU BUSH, M GRAVES, JAM OBRIEN, SJ WILDT, DE AF BUSH, M GRAVES, JAM OBRIEN, SJ WILDT, DE TI DISSOCIATIVE ANESTHESIA IN FREE-RANGING MALE KOALAS AND SELECTED MARSUPIALS IN CAPTIVITY SO AUSTRALIAN VETERINARY JOURNAL LA English DT Article ID PHASCOLARCTOS-CINEREUS; CHEETAH AB Forty seven free-ranging, adult, male koalas were captured and administered an intramuscular injection of the dissociative anaesthetic, Telazol(R) (tiletamine HCI plus zolazepam HCI), at dose rates of 5.0 to 7.7 mg/kg body weight. Anaesthesia induction was rapid and smooth and resulted in a surgical plane of anaesthesia lasting 30 to 45 min. There was no depression of heart rate or respiration. Mild salivation occurred in most animals, but was not a problem because the swallowing reflex was retained. There was no mortality or morbidity and the anaesthesia level was sufficient to allow electroejaculation and multiple blood sampling with no apparent animal discomfort. For 10 of 19 males in which anaesthesia was required for a 90 min protocol, a supplementary Telazol injection (average, 2.5 mg/kg) was necessary. All koalas recovered completely within 3 to 4 h of the initial injection. The results suggest that the optimal Telazol dosage for the adult male koala is 7.0 mg/kg body weight. The retrospective analysis of 259 anaesthesia records involving 14 species indicated that Telazol was equally effective and safe in other captive marsupials. C1 AH ROBINS CO INC,RICHMOND,VA 23220. NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701. LA TROBE UNIV,DEPT GENET & HUMAN VARIAT,BUNDOORA,VIC 3083,AUSTRALIA. RP BUSH, M (reprint author), SMITHSONIAN INST,NATL ZOOL PK,WASHINGTON,DC 20008, USA. RI Graves, Jennifer/A-1387-2008 NR 21 TC 8 Z9 9 U1 0 U2 6 PU AUSTRALIAN VETERINARY ASSN PI VICTORIA PA 272 BRUNSWICK RD BRUNSWICK, VICTORIA 3056, AUSTRALIA SN 0005-0423 J9 AUST VET J JI Aust. Vet. J. PD DEC PY 1990 VL 67 IS 12 BP 449 EP 451 DI 10.1111/j.1751-0813.1990.tb03060.x PG 3 WC Veterinary Sciences SC Veterinary Sciences GA ER565 UT WOS:A1990ER56500007 PM 2076068 ER PT J AU BACHEVALIER, J BRICKSON, M HAGGER, C MISHKIN, M AF BACHEVALIER, J BRICKSON, M HAGGER, C MISHKIN, M TI AGE AND SEX-DIFFERENCES IN THE EFFECTS OF SELECTIVE TEMPORAL-LOBE LESION ON THE FORMATION OF VISUAL-DISCRIMINATION HABITS IN RHESUS-MONKEYS (MACACA-MULATTA) SO BEHAVIORAL NEUROSCIENCE LA English DT Article RP BACHEVALIER, J (reprint author), NIMH,NEUROPSYCHOL LAB,BLDG 9,ROOM 1N107,BETHESDA,MD 20892, USA. NR 40 TC 67 Z9 67 U1 0 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7044 J9 BEHAV NEUROSCI JI Behav. Neurosci. PD DEC PY 1990 VL 104 IS 6 BP 885 EP 899 DI 10.1037/0735-7044.104.6.885 PG 15 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA EN315 UT WOS:A1990EN31500007 PM 2285487 ER PT J AU OLASHAW, NE RHEE, SG PLEDGER, WJ AF OLASHAW, NE RHEE, SG PLEDGER, WJ TI CYCLIC-AMP AGONISTS INDUCE THE PHOSPHORYLATION OF PHOSPHOLIPASE C-TAU AND OF A 76 KDA PROTEIN CO-PRECIPITATED BY ANTI-(PHOSPHOLIPASE C-TAU) MONOCLONAL-ANTIBODIES IN BALB/C-3T3 CELLS - RELATIONSHIP TO INOSITOL PHOSPHATE FORMATION SO BIOCHEMICAL JOURNAL LA English DT Article C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. RP OLASHAW, NE (reprint author), VANDERBILT UNIV,MED CTR,SCH MED,DEPT CELL BIOL,NASHVILLE,TN 37232, USA. FU NCI NIH HHS [CA 42713, CA 43720] NR 38 TC 11 Z9 11 U1 0 U2 1 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD DEC 1 PY 1990 VL 272 IS 2 BP 297 EP 303 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL941 UT WOS:A1990EL94100002 PM 1702622 ER PT J AU BURNS, AL MAGENDZO, K SRIVASTAVA, M ROJAS, E PARRA, C DELAFUENTE, M CULTRARO, C SHIRVAN, A VOGEL, T HELDMAN, J CAOHUY, H TOMBACCINI, D POLLARD, HB AF BURNS, AL MAGENDZO, K SRIVASTAVA, M ROJAS, E PARRA, C DELAFUENTE, M CULTRARO, C SHIRVAN, A VOGEL, T HELDMAN, J CAOHUY, H TOMBACCINI, D POLLARD, HB TI HUMAN SYNEXIN (ANNEXIN-VII) POLYMORPHISMS - TISSUE-SPECIFICITY AND EXPRESSION IN ESCHERICHIA-COLI SO BIOCHEMICAL SOCIETY TRANSACTIONS LA English DT Article; Proceedings Paper CT COLLOQUIUM AT THE 635TH MEETING OF THE BIOCHEMICAL SOC : LIPIDS, LIPOPROTEINS AND ANTIOXIDANTS IN CARDIOVASCULAR DYSFUNCTION CY JUL, 1990 CL ABERDEEN, SCOTLAND SP BIOCHEM SOC ID CHROMAFFIN GRANULES; MEMBRANE-FUSION; CALCIUM; AGGREGATION; VESICLES; PROTEIN; CA-2+ C1 US FDA,DIV CARDIORENAL,BETHESDA,MD 20892. RP BURNS, AL (reprint author), NIDDKD,CELL BIOL & GENET LAB,BETHESDA,MD 20892, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0300-5127 J9 BIOCHEM SOC T JI Biochem. Soc. Trans. PD DEC PY 1990 VL 18 IS 6 BP 1118 EP 1121 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EQ255 UT WOS:A1990EQ25500033 PM 2150946 ER PT J AU SIMPSON, IA CUSHMAN, SW EGAN, JJ HABBERFIELD, AD LONDOS, C NISHIMURA, H SALTIS, J AF SIMPSON, IA CUSHMAN, SW EGAN, JJ HABBERFIELD, AD LONDOS, C NISHIMURA, H SALTIS, J TI HORMONAL-REGULATION OF GLUCOSE-TRANSPORT IN RAT ADIPOSE-CELLS SO BIOCHEMICAL SOCIETY TRANSACTIONS LA English DT Article; Proceedings Paper CT COLLOQUIUM AT THE 635TH MEETING OF THE BIOCHEMICAL SOC : LIPIDS, LIPOPROTEINS AND ANTIOXIDANTS IN CARDIOVASCULAR DYSFUNCTION CY JUL, 1990 CL ABERDEEN, SCOTLAND SP BIOCHEM SOC ID PLASMA-MEMBRANE; INSULIN; TRANSLOCATION; SYSTEMS RP SIMPSON, IA (reprint author), NIDDK,CELLULAR & NUTR ENDOCRINOL BRANCH,METAB & NUTR SECT,BETHESDA,MD 20892, USA. NR 12 TC 3 Z9 3 U1 0 U2 1 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0300-5127 J9 BIOCHEM SOC T JI Biochem. Soc. Trans. PD DEC PY 1990 VL 18 IS 6 BP 1123 EP 1125 PG 3 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EQ255 UT WOS:A1990EQ25500034 PM 2088820 ER PT J AU GAIST, PA OBARZANEK, E SKWERER, RG DUNCAN, CC SHULTZ, PM ROSENTHAL, NE AF GAIST, PA OBARZANEK, E SKWERER, RG DUNCAN, CC SHULTZ, PM ROSENTHAL, NE TI EFFECTS OF BRIGHT LIGHT ON RESTING METABOLIC-RATE IN PATIENTS WITH SEASONAL AFFECTIVE-DISORDER AND CONTROL SUBJECTS SO BIOLOGICAL PSYCHIATRY LA English DT Article C1 NIMH,PSYCHOL & PSYCHOPATHOL LAB,BETHESDA,MD 20892. RP GAIST, PA (reprint author), NIMH,CLIN PSYCHOBIOL BRANCH,BIOMED PSYCNHIAT SECT,10-4S-239,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 30 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD DEC 1 PY 1990 VL 28 IS 11 BP 989 EP 996 DI 10.1016/0006-3223(90)90064-9 PG 8 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EK228 UT WOS:A1990EK22800007 PM 2275956 ER PT J AU SANG, QX STETLERSTEVENSON, WG LIOTTA, LA BYERS, SW AF SANG, QX STETLERSTEVENSON, WG LIOTTA, LA BYERS, SW TI IDENTIFICATION OF TYPE-IV COLLAGENASE IN RAT TESTICULAR CELL-CULTURE - INFLUENCE OF PERITUBULAR-SERTOLI CELL-INTERACTIONS SO BIOLOGY OF REPRODUCTION LA English DT Article C1 GEORGETOWN UNIV,MED CTR,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007. NCI,PATHOL LAB,BETHESDA,MD 20892. RI Stetler-Stevenson, William/H-6956-2012 OI Stetler-Stevenson, William/0000-0002-5500-5808 FU NICHD NIH HHS [HD 23744] NR 55 TC 44 Z9 44 U1 0 U2 0 PU SOC STUDY REPRODUCTION PI MADISON PA 1603 MONROE ST, MADISON, WI 53711-2021 SN 0006-3363 J9 BIOL REPROD JI Biol. Reprod. PD DEC PY 1990 VL 43 IS 6 BP 956 EP 964 DI 10.1095/biolreprod43.6.956 PG 9 WC Reproductive Biology SC Reproductive Biology GA EJ831 UT WOS:A1990EJ83100007 PM 1963327 ER PT J AU PIEGORSCH, WW AF PIEGORSCH, WW TI FISHER CONTRIBUTIONS TO GENETICS AND HEREDITY, WITH SPECIAL EMPHASIS ON THE GREGOR MENDEL CONTROVERSY SO BIOMETRICS LA English DT Article DE CHI-SQUARE TEST; EVOLUTION; GOODNESS OF FIT; HISTORY OF SCIENCE; NATURAL SELECTION; P-VALUES ID TOO AB R.A. Fisher is widely respected for his contributions to both statistics and genetics. For instance, his 1930 text on The Genetical Theory of Natural Selection remains a watershed contribution in that area. Fisher's subsequent research led him to study the work of (Johann) Gregor Mendel, the 19th century monk who first developed the basic principles of heredity with experiments on garden peas. In examining Mendel's original 1865 article, Fisher noted that the conformity between Mendel's reported and proposed (theoretical) ratios of segregating individuals was unusually good, "too good" perhaps. The resulting controversy as to whether Mendel "cooked" his data for presentation has continued to the current day. This review highlights Fisher's most salient points as regards Mendel's "too good" fit, within the context of Fisher's extensive contributions to the development of genetical and evolutionary theory. RP PIEGORSCH, WW (reprint author), NIEHS,STAT & BIOMATH BRANCH,RES TRIANGLE PK,NC 27709, USA. OI Piegorsch, Walter/0000-0003-2725-5604 NR 59 TC 6 Z9 6 U1 6 U2 12 PU INTERNATIONAL BIOMETRIC SOC PI WASHINGTON PA 808 17TH ST NW SUITE 200, WASHINGTON, DC 20006-3910 SN 0006-341X J9 BIOMETRICS JI Biometrics PD DEC PY 1990 VL 46 IS 4 BP 915 EP 924 DI 10.2307/2532437 PG 10 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EV521 UT WOS:A1990EV52100003 PM 2085640 ER PT J AU WEINBERG, CR WACHOLDER, S AF WEINBERG, CR WACHOLDER, S TI THE DESIGN AND ANALYSIS OF CASE CONTROL STUDIES WITH BIASED SAMPLING SO BIOMETRICS LA English DT Article DE BIASED SAMPLING; CASE CONTROL STUDIES; MATCHING; RANDOMIZED RECRUITMENT; 2-STAGE SAMPLING ID LOGISTIC-REGRESSION; DISEASE; EXPOSURE; 2-STAGE AB A design is proposed for case-control studies in which selection of subjects for full variable ascertainment is based jointly on disease status and on easily obtained "screening" variables that may be related to the disease. Recruitment of subjects follows an independent Bernoulli sampling scheme, with recruitment probabilities set by the investigator in advance. In particular, the sampling can be set up to achieve, on average, frequency matching, provided prior estimates of the disease rates or odds ratios associated with screening variables such as age and sex are available. Alternatively-for example, when studying a rare exposure-one can enrich the sample with certain categories of subject. Following such a design, there are two valid approaches to logistic regression analysis, both of which allow for efficient estimation of effects associated with the screening variables that were allowed to bias the recruitment. The statistical properties of the estimators are compared, both for large samples, based on asymptotics, and for small samples, based on simulations. C1 NCI,BIOSTAT BRANCH,BETHESDA,MD 20892. RP WEINBERG, CR (reprint author), NIEHS,DIV BIOMETRY & RISK ASSESSMENT,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 16 TC 74 Z9 75 U1 0 U2 11 PU INTERNATIONAL BIOMETRIC SOC PI WASHINGTON PA 808 17TH ST NW SUITE 200, WASHINGTON, DC 20006-3910 SN 0006-341X J9 BIOMETRICS JI Biometrics PD DEC PY 1990 VL 46 IS 4 BP 963 EP 975 DI 10.2307/2532441 PG 13 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EV521 UT WOS:A1990EV52100007 PM 2085641 ER PT J AU BENICHOU, J GAIL, MH AF BENICHOU, J GAIL, MH TI VARIANCE CALCULATIONS AND CONFIDENCE-INTERVALS FOR ESTIMATES OF THE ATTRIBUTABLE RISK BASED ON LOGISTIC-MODELS SO BIOMETRICS LA English DT Article DE ATTRIBUTABLE FRACTION; ATTRIBUTABLE RISK; CASE CONTROL STUDY; DELTA METHOD FOR IMPLICIT FUNCTIONS; ETIOLOGIC FRACTION; INFLUENCE FUNCTIONS; LOGISTIC REGRESSION ID EXPOSURE AB The attributable risk (AR), defined as AR = {Pr(disease) - Pr(disease\no exposure)}/Pr(disease), measures the proportion of disease risk that is attributable to an exposure. Recently Bruzzi et al. (1985, American Journal of Epidemiology 122, 904-914) presented point estimates of AR based on logistic models for case-control data to allow for confounding factors and secondary exposures. To produce confidence intervals, we derived variance estimates for AR under the logistic model and for various designs for sampling controls. Calculations for discrete exposure and confounding factors require covariances between estimates of the risk parameters of the logistic model and the proportions of cases with given levels of exposure and confounding factors. These covariances are estimated from Taylor series expansions applied to implicit functions. Similar calculations for continuous exposures are derived using influence functions. Simulations indicate that those asymptotic procedures yield reliable variance estimates and confidence intervals with near nominal coverage. An example illustrates the usefulness of variance calculations in selecting a logistic model that is neither so simplified as to exhibit systematic lack of fit nor so complicated as to inflate the variance of the estimate of AR. C1 NCI,BIOSTAT BRANCH,EPIDEMIOL METHODS SECT,ROCKVILLE,MD 20892. RP BENICHOU, J (reprint author), HOP ST LOUIS,DEPT BIOSTAT & INFORMAT MED,1 AVE CLAUDE VELLEFAUX,F-75475 PARIS 10,FRANCE. NR 20 TC 133 Z9 135 U1 2 U2 7 PU INTERNATIONAL BIOMETRIC SOC PI WASHINGTON PA 808 17TH ST NW SUITE 200, WASHINGTON, DC 20006-3910 SN 0006-341X J9 BIOMETRICS JI Biometrics PD DEC PY 1990 VL 46 IS 4 BP 991 EP 1003 DI 10.2307/2532443 PG 13 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EV521 UT WOS:A1990EV52100009 PM 2085643 ER PT J AU BAKER, SG AF BAKER, SG TI A SIMPLE EM ALGORITHM FOR CAPTURE RECAPTURE DATA WITH CATEGORICAL COVARIATES SO BIOMETRICS LA English DT Note DE CONDITIONAL LIKELIHOOD; LOGLINEAR MODEL; MISSING DATA; SCREENING; TRUNCATED DISTRIBUTION ID STATISTICAL-INFERENCE; CLOSED POPULATIONS; MULTINOMIAL MODELS; FALSE NEGATIVES; POISSON AB A simple EM algorithm is proposed for obtaining maximum likelihood estimates when fitting a loglinear model to data from k capture-recapture samples with categorical covariates. The method is used to analyze data on screening for the early detection of breast cancer. RP BAKER, SG (reprint author), NCI, EPN 344, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA. NR 21 TC 10 Z9 10 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0006-341X EI 1541-0420 J9 BIOMETRICS JI Biometrics PD DEC PY 1990 VL 46 IS 4 BP 1193 EP 1200 DI 10.2307/2532461 PG 8 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EV521 UT WOS:A1990EV52100027 PM 2085634 ER PT J AU BAILER, AJ PIEGORSCH, WW AF BAILER, AJ PIEGORSCH, WW TI ESTIMATING INTEGRALS USING QUADRATURE METHODS WITH AN APPLICATION IN PHARMACOKINETICS SO BIOMETRICS LA English DT Article DE AREA UNDER CURVE; EXPONENTIAL DISPOSITION MODELS; MEAN SQUARED ERROR; NEWTON-COTES QUADRATURE; NUMERICAL INTEGRATION ID COMPARATIVE BIOAVAILABILITY AB The estimation of integrals using numerical quadrature is common in many biological studies. For instance, in biopharmaceutical research the area under curves is a useful quantity in deriving pharmacokinetic parameters and in providing a surrogate measure of the total dose of a compound at a particular site. In this paper, statistical issues as separate from numerical issues are considered in choosing a quadrature rule. The class of Newton-Cotes numerical quadrature procedures is examined from the prespective of minimizing mean squared error (MSE). The MSEs are examined for a variety of functions commonly encountered in pharmacokinetics. It is seen that the simplest Newton-Cotes procedure, the trapezoidal rule, frequently provides minimum MSE for a variety of concentration-time shapes and under a variety of response variance conditions. A biopharmaceutical example is presented to illustrate these considerations. C1 NIEHS,STAT & BIOMATH BRANCH,RES TRIANGLE PK,NC 27709. RP BAILER, AJ (reprint author), MIAMI UNIV,DEPT MATH & STAT,OXFORD,OH 45056, USA. OI Piegorsch, Walter/0000-0003-2725-5604 NR 20 TC 22 Z9 22 U1 0 U2 1 PU INTERNATIONAL BIOMETRIC SOC PI WASHINGTON PA 808 17TH ST NW SUITE 200, WASHINGTON, DC 20006-3910 SN 0006-341X J9 BIOMETRICS JI Biometrics PD DEC PY 1990 VL 46 IS 4 BP 1201 EP 1211 DI 10.2307/2532462 PG 11 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EV521 UT WOS:A1990EV52100028 PM 2085635 ER PT J AU ZUCKER, DM LAKATOS, E AF ZUCKER, DM LAKATOS, E TI WEIGHTED LOG RANK TYPE STATISTICS FOR COMPARING SURVIVAL CURVES WHEN THERE IS A TIME-LAG IN THE EFFECTIVENESS OF TREATMENT SO BIOMETRIKA LA English DT Article RP ZUCKER, DM (reprint author), NHLBI,BIOSTAT RES BRANCH,BETHESDA,MD 20892, USA. NR 20 TC 52 Z9 52 U1 1 U2 10 PU BIOMETRIKA TRUST PI LONDON PA UNIV COLLEGE LONDON GOWER ST-BIOMETRIKA OFFICE, LONDON, ENGLAND WC1E 6BT SN 0006-3444 J9 BIOMETRIKA JI Biometrika PD DEC PY 1990 VL 77 IS 4 BP 853 EP 864 DI 10.1093/biomet/77.4.853 PG 12 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA EM616 UT WOS:A1990EM61600018 ER PT J AU LEONARD, EJ YOSHIMURA, T SKEEL, A GOODWIN, R AF LEONARD, EJ YOSHIMURA, T SKEEL, A GOODWIN, R TI A MULTIWELL CELL SETTLING AND ADHERENCE CHAMBER FOR MORPHOLOGY AND DIFFERENTIAL COUNTING SO BIOTECHNIQUES LA English DT Note C1 NEURO PROBE INC,CABIN JOHN,MD 20818. RP LEONARD, EJ (reprint author), NCI,FREDERICK CANC RES FACIL,IMMUNOBIOL LAB,IMMUNOPATHOL SECT,BLDG 560,ROOM 12-71,FREDERICK,MD 21702, USA. NR 5 TC 7 Z9 7 U1 0 U2 1 PU EATON PUBLISHING CO PI NATICK PA 154 E. CENTRAL ST, NATICK, MA 01760 SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD DEC PY 1990 VL 9 IS 6 BP 684 EP & PG 0 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL328 UT WOS:A1990EL32800003 PM 1702974 ER PT J AU BERG, M JAMES, SP AF BERG, M JAMES, SP TI HUMAN NEUTROPHILS RELEASE THE LEU-8 LYMPH-NODE HOMING RECEPTOR DURING CELL ACTIVATION SO BLOOD LA English DT Article C1 NIAID,CLIN INVEST LAB,MUCOSAL IMMUN SECT,BLDG 10,ROOM 11N-250,BETHESDA,MD 20892. NR 31 TC 75 Z9 75 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 1 PY 1990 VL 76 IS 11 BP 2381 EP 2388 PG 8 WC Hematology SC Hematology GA EK727 UT WOS:A1990EK72700032 PM 1701670 ER PT J AU WEISSE, CS PATO, CN MCALLISTER, CG LITTMAN, R BREIER, A PAUL, SM BAUM, A AF WEISSE, CS PATO, CN MCALLISTER, CG LITTMAN, R BREIER, A PAUL, SM BAUM, A TI DIFFERENTIAL-EFFECTS OF CONTROLLABLE AND UNCONTROLLABLE ACUTE STRESS ON LYMPHOCYTE-PROLIFERATION AND LEUKOCYTE PERCENTAGES IN HUMANS SO BRAIN BEHAVIOR AND IMMUNITY LA English DT Article ID IMMUNE FUNCTION; LEARNED HELPLESSNESS; AFFECTIVE-DISORDERS; MEDICAL-STUDENTS; NEURO-ENDOCRINE; IMMUNOCOMPETENCE; BEREAVEMENT; DEPRESSION; BLOOD; RAT C1 NIMH,SCHIZOPHRENIA RES BRANCH,ROCKVILLE,MD 20857. UNIV PITTSBURGH,DEPT PSYCHIAT & PATHOL,PITTSBURGH,PA 15213. UNIV PITTSBURGH,CTR BRAIN BEHAV & IMMUN,PITTSBURGH,PA 15213. NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892. MARYLAND PSYCHIAT RES CTR,BALTIMORE,MD 21228. UNIFORMED SERV UNIV HLTH SCI,DEPT MED PSYCHOL,BETHESDA,MD 20814. RP WEISSE, CS (reprint author), UNION UNIV UNION COLL,DEPT PSYCHOL,SCHENECTADY,NY 12308, USA. NR 39 TC 72 Z9 73 U1 1 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0889-1591 J9 BRAIN BEHAV IMMUN JI Brain Behav. Immun. PD DEC PY 1990 VL 4 IS 4 BP 339 EP 351 DI 10.1016/0889-1591(90)90037-Q PG 13 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA EX640 UT WOS:A1990EX64000008 PM 2092868 ER PT J AU WUWILLIAMS, AH DAI, XD BLOT, W XU, ZY SUN, XW XIAO, HP STONE, BJ YU, SF FENG, YP ERSHOW, AG SUN, J FRAUMENI, JF HENDERSON, BE AF WUWILLIAMS, AH DAI, XD BLOT, W XU, ZY SUN, XW XIAO, HP STONE, BJ YU, SF FENG, YP ERSHOW, AG SUN, J FRAUMENI, JF HENDERSON, BE TI LUNG-CANCER AMONG WOMEN IN NORTH-EAST CHINA SO BRITISH JOURNAL OF CANCER LA English DT Article C1 NCI,BETHESDA,MD 20892. HARBIN MED SCH,HARBIN,PEOPLES R CHINA. LIAONING PUBL HLTH & ANTI EPIDEM STN,SHENYANG,PEOPLES R CHINA. RP WUWILLIAMS, AH (reprint author), UNIV SO CALIF,SCH MED,DEPT PREVENT MED,LOS ANGELES,CA 90033, USA. NR 25 TC 226 Z9 227 U1 0 U2 4 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD DEC PY 1990 VL 62 IS 6 BP 982 EP 987 DI 10.1038/bjc.1990.421 PG 6 WC Oncology SC Oncology GA EL823 UT WOS:A1990EL82300023 PM 2257230 ER PT J AU OLSEN, JH BOICE, JD FRAUMENI, JF AF OLSEN, JH BOICE, JD FRAUMENI, JF TI CANCER IN CHILDREN OF EPILEPTIC MOTHERS AND THE POSSIBLE RELATION TO MATERNAL ANTICONVULSANT THERAPY SO BRITISH JOURNAL OF CANCER LA English DT Article C1 NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892. RP OLSEN, JH (reprint author), ROSENVAENGETS,DANISH CANC REGISTRY,HOVEDVEJ 35,BOX 839,DK-2100 COPENHAGEN,DENMARK. NR 22 TC 13 Z9 13 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD DEC PY 1990 VL 62 IS 6 BP 996 EP 999 DI 10.1038/bjc.1990.424 PG 4 WC Oncology SC Oncology GA EL823 UT WOS:A1990EL82300026 PM 2257233 ER PT J AU VARGA, K KUNOS, G AF VARGA, K KUNOS, G TI ETHANOL INHIBITION OF BAROREFLEX BRADYCARDIA - ROLE OF BRAIN-STEM GABA RECEPTORS SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Article C1 NIAAA,PHYSIOL & PHARMACOL STUDIES LAB,12501 WASHINGTON AVE,ROCKVILLE,MD 20852. NR 10 TC 40 Z9 40 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD DEC PY 1990 VL 101 IS 4 BP 773 EP 775 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EL193 UT WOS:A1990EL19300002 PM 1964817 ER PT J AU GARBER, JE LIEPMAN, MK GELLES, EJ CORSON, JM ANTMAN, KH AF GARBER, JE LIEPMAN, MK GELLES, EJ CORSON, JM ANTMAN, KH TI MELANOMA AND SOFT-TISSUE SARCOMA IN 7 PATIENTS SO CANCER LA English DT Article C1 NCI,CLIN EPIDEMIOL BRANCH,CLIN STUDIES SECT,BETHESDA,MD 20892. CENT MASSACHUSETTS MEM HOSP,MED CTR,DIV HEMATOL ONCOL,WORCESTER,MA. BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115. RP GARBER, JE (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV MED ONCOL,44 BINNEY ST,BOSTON,MA 02115, USA. NR 21 TC 14 Z9 14 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 1 PY 1990 VL 66 IS 11 BP 2432 EP 2434 DI 10.1002/1097-0142(19901201)66:11<2432::AID-CNCR2820661132>3.0.CO;2-C PG 3 WC Oncology SC Oncology GA EL262 UT WOS:A1990EL26200031 PM 2245401 ER PT J AU LIOTTA, LA AF LIOTTA, LA TI THE ROLE OF CELLULAR PROTEASES AND THEIR INHIBITORS IN INVASION AND METASTASIS - INTRODUCTIONARY OVERVIEW SO CANCER AND METASTASIS REVIEWS LA English DT Editorial Material RP LIOTTA, LA (reprint author), NCI,DIV CANC BIOL DIAG & CTR,PATHOL LAB,BLDG 10,RM 2A33,BETHESDA,MD 20892, USA. NR 16 TC 28 Z9 28 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-7659 J9 CANCER METAST REV JI Cancer Metastasis Rev. PD DEC PY 1990 VL 9 IS 4 BP 285 EP 287 DI 10.1007/BF00049519 PG 3 WC Oncology SC Oncology GA EW326 UT WOS:A1990EW32600001 PM 2097082 ER PT J AU STETLERSTEVENSON, WG AF STETLERSTEVENSON, WG TI TYPE-IV COLLAGENASES IN TUMOR INVASION AND METASTASIS SO CANCER AND METASTASIS REVIEWS LA English DT Review DE COLLAGENASE; METASTASIS; TIMP; INVASION ID ERYTHROID-POTENTIATING ACTIVITY; BASEMENT-MEMBRANE COLLAGEN; SKIN FIBROBLAST COLLAGENASE; HUMAN AMNIOTIC MEMBRANE; TISSUE INHIBITOR; PLASMINOGEN-ACTIVATOR; ENDOTHELIAL-CELLS; ALVEOLAR MACROPHAGES; MELANOMA-CELLS; MURINE TUMOR AB The invasion and metastasis of cancer cells is a complex multistep process involving destruction of basement membranes as an early event in the metastatic cascade. Recent evidence implicates secreted matrix metalloproteinase enzymes, such as type IV collagenases, as playing a central role in this tumor cell mediated extracellular matrix proteolysis. Two distinct type IV collagenase enzymes are now recognized. Immunohistochemical and biochemical studies of several human tumors show correlations between invasive potential and the 72 kDa type IV collagenase enzyme. Studies in rodent tumor models suggest that the 92 kDa type IV collagenase may play an important role in these models, but data on human tumors and human tumor tissue is lacking. Evidence suggest that the regulation of the 72 kDa type IV collagenase enzyme activity may occur at many levels, including transcriptional mechanisms, extracellular activation of latent enzyme and specific inhibitors of active enzyme. Thus the invasion of human tumor cells through basement membranes may be the result of net type IV collagenolytic activity that is the result of a balance of activated enzyme species and inhibitors. RP STETLERSTEVENSON, WG (reprint author), NCI,PATHOL LAB,BLDG 10,ROOM 2A33,900 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. RI Stetler-Stevenson, William/H-6956-2012 OI Stetler-Stevenson, William/0000-0002-5500-5808 NR 87 TC 442 Z9 447 U1 2 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-7659 J9 CANCER METAST REV JI Cancer Metastasis Rev. PD DEC PY 1990 VL 9 IS 4 BP 289 EP 303 DI 10.1007/BF00049520 PG 15 WC Oncology SC Oncology GA EW326 UT WOS:A1990EW32600002 PM 1965794 ER PT J AU MORRISON, DK AF MORRISON, DK TI THE RAF-1 KINASE AS A TRANSDUCER OF MITOGENIC SIGNALS SO CANCER CELLS-A MONTHLY REVIEW LA English DT Review ID COMPLETE CODING SEQUENCE; PHOSPHOLIPASE-C-GAMMA; V-RAF; TYROSINE PHOSPHORYLATION; TRANSFORMING ACTIVITY; PDGF RECEPTOR; ONCOGENE; PROTEIN; ACTIVATION; REARRANGEMENT AB Cells respond to proliferative signals generated by growth factors and oncogenes with a complex array of biochemical and physiological events, culminating in DNA synthesis and cell division. One of the molecules thought to be critical for the transmission and amplification of mitogenic signals from the cell surface to the nucleus is the proto-oncogene product Raf-1. Raf-1 is a serine-threonine kinase that is itself phosphorylated in response to mitogenic stimulation. The phosphorylation state of Raf-1 appears to modulate its kinase activity. Experiments linking Raf-1 to other characterized components of the signal transduction machinery are reviewed here. RP MORRISON, DK (reprint author), NCI,FREDERICK CANC RES & DEV CTR,ABL,BASIC RES PROGRAM,POB B,FREDERICK,MD 21701, USA. FU NCI NIH HHS [N01-CO-74101] NR 44 TC 72 Z9 74 U1 0 U2 0 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 1042-2196 J9 CANCER CELL-MON REV PD DEC PY 1990 VL 2 IS 12 BP 377 EP 382 PG 6 WC Oncology; Medicine, Research & Experimental SC Oncology; Research & Experimental Medicine GA EP819 UT WOS:A1990EP81900001 PM 2150916 ER PT J AU SALOMON, DS KIM, N SAEKI, T CIARDIELLO, F AF SALOMON, DS KIM, N SAEKI, T CIARDIELLO, F TI TRANSFORMING GROWTH FACTOR-ALPHA - AN ONCODEVELOPMENTAL GROWTH-FACTOR SO CANCER CELLS-A MONTHLY REVIEW LA English DT Review ID ALPHA-MESSENGER-RNA; TGF-ALPHA; EGF-RECEPTOR; BREAST-CANCER; FACTOR-BETA; HEPATOCELLULAR-CARCINOMA; RIBONUCLEIC-ACID; RAT FIBROBLASTS; CELL-LINE; EXPRESSION AB Transforming growth factor-alpha-(TGF-alpha) is a 5-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately-160 amino acids. The low-molecular-weight TGF-alpha-peptide as well as the precursor are biologically active in a number of systems and can function as transforming proteins when overexpressed. TGF-alpha-binds to and activates the EGF receptor, and TGF-alpha and the EGF receptor are coexpressed in a number of human and rodent tumors and tumor cell lines - which suggests that TGF-alpha-can function as an autocrine or paracrine growth factor. TGF-alpha is transiently expressed in some fetal and adjacent maternal tissues during development and is also expressed in a number of adult tissues; this pattern of expression suggests that the growth factor is involved in several distinct physiological functions. RP SALOMON, DS (reprint author), NCI,DIV CANC BIOL DIAG & CTR,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892, USA. OI Ciardiello, Fortunato/0000-0002-3369-4841 NR 65 TC 113 Z9 118 U1 0 U2 1 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 1042-2196 J9 CANCER CELL-MON REV PD DEC PY 1990 VL 2 IS 12 BP 389 EP 397 PG 9 WC Oncology; Medicine, Research & Experimental SC Oncology; Research & Experimental Medicine GA EP819 UT WOS:A1990EP81900003 PM 2088454 ER PT J AU KUFF, EL AF KUFF, EL TI INTRACISTERNAL-A PARTICLES IN MOUSE NEOPLASIA SO CANCER CELLS-A MONTHLY REVIEW LA English DT Editorial Material ID C-MOS ONCOGENE; CELLULAR ONCOGENE; DNA REARRANGEMENT; HOMEOBOX GENE; ACTIVATION; SEQUENCES; INSERTION; CELLS; HYBRIDOMAS; LEUKEMIA RP KUFF, EL (reprint author), NCI,BIOCHEM LAB,BETHESDA,MD 20892, USA. NR 24 TC 42 Z9 43 U1 0 U2 1 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 1042-2196 J9 CANCER CELL-MON REV PD DEC PY 1990 VL 2 IS 12 BP 398 EP 400 PG 3 WC Oncology; Medicine, Research & Experimental SC Oncology; Research & Experimental Medicine GA EP819 UT WOS:A1990EP81900004 PM 1965135 ER PT J AU HAMPTON, LL WORLAND, PJ YU, B THORGEIRSSON, SS HUGGETT, AC AF HAMPTON, LL WORLAND, PJ YU, B THORGEIRSSON, SS HUGGETT, AC TI EXPRESSION OF GROWTH-RELATED GENES DURING TUMOR PROGRESSION IN V-RAF-TRANSFORMED RAT-LIVER EPITHELIAL-CELLS SO CANCER RESEARCH LA English DT Article C1 NCI,EXPTL CARCINOGENESIS LAB,BLDG 37,ROOM 3C28,BETHESDA,MD 20892. NR 70 TC 25 Z9 25 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 1 PY 1990 VL 50 IS 23 BP 7460 EP 7467 PG 8 WC Oncology SC Oncology GA EK642 UT WOS:A1990EK64200008 PM 1701345 ER PT J AU HUGGETT, AC HAMPTON, LL FORD, CP WIRTH, PJ THORGEIRSSON, SS AF HUGGETT, AC HAMPTON, LL FORD, CP WIRTH, PJ THORGEIRSSON, SS TI ALTERED RESPONSIVENESS OF RAT-LIVER EPITHELIAL-CELLS TO TRANSFORMING GROWTH FACTOR-BETA-1 FOLLOWING THEIR TRANSFORMATION WITH V-RAF SO CANCER RESEARCH LA English DT Article C1 NCI, DIV CANC ETIOL,EXPTL CARCINOGENESIS LAB,BLDG 37, ROOM 3C28, BETHESDA, MD 20892 USA. NR 59 TC 44 Z9 44 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 1 PY 1990 VL 50 IS 23 BP 7468 EP 7475 PG 8 WC Oncology SC Oncology GA EK642 UT WOS:A1990EK64200009 PM 2174726 ER PT J AU NEWBOLD, RR BULLOCK, BC MCLACHLAN, JA AF NEWBOLD, RR BULLOCK, BC MCLACHLAN, JA TI UTERINE ADENOCARCINOMA IN MICE FOLLOWING DEVELOPMENTAL TREATMENT WITH ESTROGENS - A MODEL FOR HORMONAL CARCINOGENESIS SO CANCER RESEARCH LA English DT Article C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT COMPARAT MED,WINSTON SALEM,NC 27103. RP NEWBOLD, RR (reprint author), NIEHS,DIV INTRAMURAL RES,REPROD & DEV TOXICOL LAB,DEV ENDOCRINOL & PHARMACOL SECT,RES TRIANGLE PK,NC 27709, USA. NR 23 TC 258 Z9 263 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 1 PY 1990 VL 50 IS 23 BP 7677 EP 7681 PG 5 WC Oncology SC Oncology GA EK642 UT WOS:A1990EK64200040 PM 2174729 ER PT J AU JIAN, NY GU, TG LIANG, X MURPHY, MJ WAY, L GAO, NH GU, JR FUHRER, JP AF JIAN, NY GU, TG LIANG, X MURPHY, MJ WAY, L GAO, NH GU, JR FUHRER, JP TI ENHANCED EXPRESSION OF GANGLIOSIDE GD3 IN HUMAN AND RAT HEPATOCELLULAR-CARCINOMA CELLS AND NIH-3T3 CELLS TRANSFECTED WITH HUMAN TUMOR DNAS SO CANCER RESEARCH LA English DT Article C1 HIPPLE CANC RES CTR,HUMAN TUMOR MARKER LAB,4100 S KETTERING BLVD,DAYTON,OH 45439. SHANGHAI MED UNIV,DEPT BIOCHEM,SHANGHAI 200032,PEOPLES R CHINA. SHANGHAI MED UNIV,INST CANC,SHANGHAI 200032,PEOPLES R CHINA. NIDDKD,STRUCT BIOL LAB,BETHESDA,MD 20892. NR 35 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 1 PY 1990 VL 50 IS 23 BP 7697 EP 7702 PG 6 WC Oncology SC Oncology GA EK642 UT WOS:A1990EK64200043 ER PT J AU REED, E GUPTABURT, S LITTERST, CL POIRIER, MC AF REED, E GUPTABURT, S LITTERST, CL POIRIER, MC TI CHARACTERIZATION OF THE DNA DAMAGE RECOGNIZED BY AN ANTISERUM ELICITED AGAINST CIS-DIAMMINEDICHLOROPLATINUM (II)-MODIFIED DNA SO CARCINOGENESIS LA English DT Article ID CANCER-PATIENTS; DEOXYRIBONUCLEIC-ACID; MONOCLONAL-ANTIBODIES; ADDUCT LEVELS; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); QUANTITATION; TRANS-DIAMMINEDICHLOROPLATINUM(II); INVITRO AB A series of in vitro and in vivo studies were performed to characterize DNA damage recognized by an antiserum elicited against DNA modified with cis-diamminedichloroplatinum (II) (cisplatin). Adducts determined by the cisplatin-DNA enzymelinked immunosorbent assay (ELISA) in human blood cell DNA have been shown to correlate well with positive clinical outcome in testicular and ovarian cancer patients receiving platinum drug-based chemotherapy (Reed et. al. (1990) Proc. Natl. Acad. Sci., 84; 5024, and Reed et al. (1988) Carcinogenesis, 9, 1909). DNAs from calf thymus, salmon sperm, pBR322 and synthetic oligonucleotides were modified with cisplatin in vitro before or after specific DNA digestion steps to yeild adducted samples of known size and/or chemical composition. These cisplatin modified DNAs were assayed by atomic absorption spectrometry (AAS) to assess absolute specificity. The antiserum recognizes native cisplatin-modified calf thymus DNA, and native oligonucleotides containing intrastrand cis-Pt (NH3)2-d(pGpG) adducts (Pt-GG) and intrastrand cis-Pt (NH3)2-d(pApG) adducts (Pt-AG). Modified plasmid DNA fragments of varying sizes (down to 309 base pairs) are recognized similarly to cisplatin-modified calf thymus DNA. The antiserum does not cross-react with individual Pt-GG or Pt-AG adducts not bound to DNA. In experiments designed to assess the relationship between adduct measured by ELISA and total platinum bound to DNA as measured by AAS, male and female Sprague-Dawley rats were injected i.p. with cisplatin and a dose response for adduct formation was determined in kidney DNA samples. Values obtained by ELISA were substantially lower than those measured by AAS, and the two were directly related in DNA from kidney tissues, of rodents but not in DNA from human nucleated blood cells. In rodent samples the ELISA measured a consistent 0.2% of the total DNA-bound platinum determined by AAS, with a correlation coefficient of 0.91. Among 54 blood cell DNA samples from human patients, which gave measurable adduct values in both ELISA and AAS, the ELISA measured a variable fraction (0.2-33.0%) of the total DNA-bound platinum measured by AAS. We conclude that the cisplatin-DNA ELISA measures a three dimensional lesion in DNA that is formed in direct proportion to total DNA-bound platinum in rat kidney, but that in human biological samples, interindividual variability precludes a relationship that conforms to simple mathematical algorithms. C1 NCI,MED BRANCH,BLDG 10,RM 6N119,BETHESDA,MD 20892. NCI,DIV CANC ETIOL,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,BLD 37,BETHESDA,MD 20892. NIAID,AIDS PROGRAM,DEV THERAPEUT BRANCH,BETHESDA,MD 20892. NR 29 TC 27 Z9 27 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0143-3334 J9 CARCINOGENESIS JI Carcinogenesis PD DEC PY 1990 VL 11 IS 12 BP 2117 EP 2121 DI 10.1093/carcin/11.12.2117 PG 5 WC Oncology SC Oncology GA EP561 UT WOS:A1990EP56100006 PM 1979937 ER PT J AU KONISHI, N DIWAN, BA WARD, JM AF KONISHI, N DIWAN, BA WARD, JM TI AMELIORATION OF SODIUM BARBITAL-INDUCED NEPHROPATHY AND REGENERATIVE TUBULAR HYPERPLASIA AFTER A SINGLE INJECTION OF STREPTOZOTOCIN DOES NOT ABOLISH THE RENAL TUMOR PROMOTING EFFECT OF BARBITAL SODIUM IN MALE F344/NCR RATS SO CARCINOGENESIS LA English DT Article ID MALIGNANT KIDNEY TUMORS; CYTO-TOXICITY; DNA-SYNTHESIS; INDUCTION; LIVER; MICE; DIMETHYLNITROSAMINE; NEPHROTOXICITY; CARCINOGENESIS; PROTECTION AB The renal tumor promoting activity of barbital sodium (BBNa) and the role of renal tubular cell hyperplasia in tumor promotion following initiation with streptozotocin (STZ) was investigated. Six week old male F344/NCr rats were given STZ as a single i.p. injection of 50 mg/kg body wt and beginning 2 weeks later were fed diets containing 0 or 4000 p.p.m. of BBNa until they were killed at 33, 52 or 72 experimental weeks for histological evaluation and determination of levels of renal DNA synthesis by bromodeoxyuridine (Brdu) immunohistochemistry. A promoting effect on renal carcinogenesis was found by 72 weeks, but not at 33 or 52 weeks, confirming that prolonged administration of BBNa is necessary to promote renal tubular cell neoplasms. The promoting effect was evident as a higher incidence of large renal tubular tumors after 52 weeks, rather than an increase in number of dysplastic tubules, putative preneoplastic lesions. These findings suggest that the targets for the promoting activity of BBNa may be dysplastic lesions which may progress to tumors. Detailed exmination by the step section technique through the entire kidneys revealed that STZ or BBNa administration induced a high incidence of putative preneoplastic renal tubular lesions (dysplasias) which seemed to be derived from the P1 or P2 segment of the nephron, also a site of high Brdu labeling index (LI) associated with attenuation of BBNa-induced nephropathy and with diabetes from pancreatic islet degeneration and atrophy. The reduction in severity of nephropathy was correlated with a reduction in the LI of the renal cortical and medullary tubules, but not with the renal tumor incidence. These results indicate that decreased DNA synthesis in target cells does not eliminate tumor promoting activity in renal tubular epithelium. In addition, BBNa alone induced papillomas of the transitional epithelium of the renal pelvis and renal tubular cell adenomas. C1 NCI,COMPARAT CARCINOGENESIS LAB,TUMOR PATHOL & PATHOGENESIS SECT,FREDERICK,MD 21702. PRI DYNCORP,FREDERICK CANC RES & DEV CTR,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702. FU NCI NIH HHS [N01-CO-74102] NR 33 TC 11 Z9 11 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0143-3334 J9 CARCINOGENESIS JI Carcinogenesis PD DEC PY 1990 VL 11 IS 12 BP 2149 EP 2156 DI 10.1093/carcin/11.12.2149 PG 8 WC Oncology SC Oncology GA EP561 UT WOS:A1990EP56100012 PM 2148284 ER PT J AU ENOMOTO, T WARD, JM PERANTONI, AO AF ENOMOTO, T WARD, JM PERANTONI, AO TI H-RAS ACTIVATION AND RAS P21 EXPRESSION IN BLADDER-TUMORS INDUCED IN F344/NCR RATS BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE SO CARCINOGENESIS LA English DT Article ID POINT MUTATION; K-RAS; GENETIC ALTERATIONS; B6C3F1 MOUSE; LUNG-TUMORS; ONCOGENES; PROTOONCOGENE; CARCINOMAS; CANCER; MICE AB Bladder tumors were induced in male F344/NCr rats by administration of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at 500 p.p.m. in their drinking water for 12 weeks. Twenty-one bladder tumors that developed between 25 and 50 weeks after BBN administration was begun were evaluated for immunoreactivity with polyclonal or monoclonal anti-bodies raised against ras p21, for amplification of ras genes by Southern blotting, and for activating point mutations in ras genes by selective oligonucleotide hybridization of products from polymerase chain reaction (PCR). Increased expression of ras p21 was detected by avidin - biotin immuno-histochemistry in 18/21 (85%) of the neoplastic bladder lesions. By Southern analysis, there was no significant amplification of H-ras, K-ras or N-ras in any of the tumors except one that showed a 5-fold amplification of K-ras. Point mutations in ras genes were detected by selective oligonucleotide hybridization of the products of PCR. Of the 21 bladder tumors, three tumors were shown to have mutations in codon 12 (GGA --> GAA), six tumors in codon 61 (two CAA --> CTA, four CAA --> CGA), and one in both codon 12 (GGA --> GAA) and codon 61 (CAA --> CGA), all in H-ras. Thus 10 of 21 tumors had ras gene mutations in a portion of the tumor cells. The variable pattern of point mutation in H-ras suggests that these mutations may not all be a direct consequence of interaction of BBN metabolites with H-ras. Enhanced expression of ras p21 was always focal and was not necessarily associated with transforming ras mutations. It is therefore suggested that tumorigenesis in BBN-initiated bladder cells might involve H-ras activation as part of a multistep pathway; however, H-ras involvement is not obligatory for tumor development. RP ENOMOTO, T (reprint author), NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702, USA. NR 43 TC 12 Z9 12 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0143-3334 J9 CARCINOGENESIS JI Carcinogenesis PD DEC PY 1990 VL 11 IS 12 BP 2233 EP 2238 PG 6 WC Oncology SC Oncology GA EP561 UT WOS:A1990EP56100025 PM 2265474 ER PT J AU BIGGER, CAH FLICKINGER, DJ STRANDBERG, J PATAKI, J HARVEY, RG DIPPLE, A AF BIGGER, CAH FLICKINGER, DJ STRANDBERG, J PATAKI, J HARVEY, RG DIPPLE, A TI MUTATIONAL SPECIFICITY OF THE ANTI 1,2-DIHYDRODIOL 3,4-EPOXIDE OF 5-METHYLCHRYSENE SO CARCINOGENESIS LA English DT Note ID CHEMICAL CARCINOGENESIS; DIHYDRODIOL-EPOXIDES; SHUTTLE-VECTOR; DIOL-EPOXIDE; DNA; ADDUCTS; ADENINE; CELLS AB An SV40-based pS189 shuttle vector, which contained a supF target gene and was replicated in human cells (Ad293), was used to determine the mutational specificity of anti 5-methylchrysene 1,2-dihydrodiol 3,4-expoxide, the active metabolite of the environmentally prevalent carcinogen 5-methylchrysene. The frequency of supF mutants containing point mutations increased with dose to approximately 40 times the spontaneous frequency. The induced mutations were not randomly distributed but occurred preferentially at mutagenic hotspots, which were not all identified to those reported by others for benzo[alpha]pyrene dihydrodiol epoxide, a metabolite with similar chemistry. C1 NCI,FREDERICK CANC RES & DEV CTR,ABL,BASIC RES PROGRAM,CHEM CARCINOGENESIS LAB,FREDERICK,MD 21702. UNIV CHICAGO,BEN MAY INST,CHICAGO,IL 60637. FU NCI NIH HHS [N01-CO-74101, CA36097] NR 20 TC 26 Z9 26 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0143-3334 J9 CARCINOGENESIS JI Carcinogenesis PD DEC PY 1990 VL 11 IS 12 BP 2263 EP 2265 DI 10.1093/carcin/11.12.2263 PG 3 WC Oncology SC Oncology GA EP561 UT WOS:A1990EP56100031 PM 2176139 ER PT J AU SAITO, T PARDOLL, DM FOWLKES, BJ OHNO, H AF SAITO, T PARDOLL, DM FOWLKES, BJ OHNO, H TI A MURINE THYMOCYTE CLONE EXPRESSING GAMMA-DELTA-T-CELL RECEPTOR MEDIATES NATURAL KILLER-LIKE CYTOLYTIC FUNCTION AND TH1-LIKE LYMPHOKINE PRODUCTION SO CELLULAR IMMUNOLOGY LA English DT Article C1 NIAID,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892. JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV MOLEC & CLIN RHEUMATOL,BALTIMORE,MD 21205. RP SAITO, T (reprint author), CHIBA UNIV,CTR NEUROBIOL & MOLEC IMMUNOL,DIV MOLEC GENET,CHIBA,JAPAN. RI Saito, Takashi/C-9684-2009; Ohno, Hiroshi/L-7899-2014 OI Saito, Takashi/0000-0001-9495-3547; Ohno, Hiroshi/0000-0001-8776-9661 NR 55 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD DEC PY 1990 VL 131 IS 2 BP 284 EP 301 DI 10.1016/0008-8749(90)90255-P PG 18 WC Cell Biology; Immunology SC Cell Biology; Immunology GA EL718 UT WOS:A1990EL71800003 PM 2146987 ER PT J AU DANNER, RL NATANSON, C ELIN, RJ HOSSEINI, JM BANKS, S MACVITTIE, TJ PARRILLO, JE AF DANNER, RL NATANSON, C ELIN, RJ HOSSEINI, JM BANKS, S MACVITTIE, TJ PARRILLO, JE TI PSEUDOMONAS-AERUGINOSA COMPARED WITH ESCHERICHIA-COLI PRODUCES LESS ENDOTOXEMIA BUT MORE CARDIOVASCULAR DYSFUNCTION AND MORTALITY IN A CANINE MODEL OF SEPTIC SHOCK SO CHEST LA English DT Article C1 NIH,WARREN G MAGNUSON CLIN CTR,DEPT CLIN PATHOL,BETHESDA,MD 20892. ARMED FORCES RADIOBIOL RES INST,BETHESDA,MD 20814. RP DANNER, RL (reprint author), NIH,WARREN G MAGNUSON CLIN CTR,DEPT CRIT CARE MED,BLDG 10,ROOM 10D48,BETHESDA,MD 20892, USA. NR 48 TC 51 Z9 51 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD DEC PY 1990 VL 98 IS 6 BP 1480 EP 1487 DI 10.1378/chest.98.6.1480 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EL307 UT WOS:A1990EL30700036 PM 2245691 ER PT J AU KOCHANSKA, G AF KOCHANSKA, G TI MATERNAL BELIEFS AS LONG-TERM PREDICTORS OF MOTHER-CHILD INTERACTION AND REPORT SO CHILD DEVELOPMENT LA English DT Article ID DEPRESSION; PATTERNS; BEHAVIOR RP KOCHANSKA, G (reprint author), NIMH,DEV PSYCHOL LAB,BLDG 15 K,BETHESDA,MD 20892, USA. NR 25 TC 48 Z9 48 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0009-3920 J9 CHILD DEV JI Child Dev. PD DEC PY 1990 VL 61 IS 6 BP 1934 EP 1943 DI 10.1111/j.1467-8624.1990.tb03576.x PG 10 WC Psychology, Educational; Psychology, Developmental SC Psychology GA EU583 UT WOS:A1990EU58300021 PM 2083506 ER PT J AU CANNON, RO PEDEN, DB BERKEBILE, C SCHENKE, WH KALINER, MA EPSTEIN, SE AF CANNON, RO PEDEN, DB BERKEBILE, C SCHENKE, WH KALINER, MA EPSTEIN, SE TI AIRWAY HYPERRESPONSIVENESS IN PATIENTS WITH MICROVASCULAR ANGINA - EVIDENCE FOR A DIFFUSE DISORDER OF SMOOTH-MUSCLE RESPONSIVENESS SO CIRCULATION LA English DT Article C1 NIAID,CLIN INVEST LAB,ALLERGY DIS SECT,BETHESDA,MD 20892. RP CANNON, RO (reprint author), NHLBI,CARDIOL BRANCH,BLDG 10,ROOM 7B-15,BETHESDA,MD 20892, USA. NR 23 TC 27 Z9 27 U1 0 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD DEC PY 1990 VL 82 IS 6 BP 2011 EP 2017 PG 7 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EL841 UT WOS:A1990EL84100014 PM 2242525 ER PT J AU ROBINSON, PJ AF ROBINSON, PJ TI MEASUREMENT OF BLOOD-BRAIN-BARRIER PERMEABILITY SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY LA English DT Article DE BRAIN UPTAKE INDEX; CAPILLARY HETEROGENEITY; CAPILLARY RECRUITMENT; CEREBRAL BLOOD FLOW; INDICATOR DILUTION; INSITU BRAIN PERFUSION; PERMEABILITY-SURFACE AREA PRODUCT; PROTEIN BINDING ID AMINO-ACID TRANSPORT; HEPATIC ELIMINATION; KINETICS; ALBUMIN; GLUCOSE; RAT; CAPILLARIES; SUBSTANCES; PERFUSION; INJECTION AB 1. Experimental determinations of blood-brain barrier permeability from measurements of uptake of tracers by brain are limited in two ways. First, there are experimental limitations that are specific to the particular method being used. These limitations include the range of permeability values that a particular method can reliably determine (sensitivity); whether repeated experiments are possible in the same animal; whether regional values can be determined; and to what degree the chemical composition of the perfusate passing through the brain can be controlled. 2. A second set of limitations on permeability determinations is of a more general, physiological nature. These constraints apply to a greater or lesser degree to all experimental determinations, and may limit the accuracy and reliability of the permeability values obtained; although certain reliable upper and lower bounds can be determined. These general factors include: capillary heterogeneity (i.e. variations in capillary lengths, surface areas, blood flows, etc.); the possibility of binding to circulating plasma proteins, especially albumin; and the possibility of capillary recruitment and de-recruitment with changes in cerebral blood flow. C1 NIA,NEUROSCI LAB,BETHESDA,MD 20892. NR 43 TC 12 Z9 12 U1 0 U2 0 PU BLACKWELL SCIENCE PI CARLTON PA 54 UNIVERSITY ST, P O BOX 378, CARLTON VICTORIA 3053, AUSTRALIA SN 0305-1870 J9 CLIN EXP PHARMACOL P JI Clin. Exp. Pharmacol. Physiol. PD DEC PY 1990 VL 17 IS 12 BP 829 EP 840 DI 10.1111/j.1440-1681.1990.tb01286.x PG 12 WC Pharmacology & Pharmacy; Physiology SC Pharmacology & Pharmacy; Physiology GA FC601 UT WOS:A1990FC60100003 PM 2092951 ER PT J AU EMANCIPATOR, K BOCK, JL BURKE, MD AF EMANCIPATOR, K BOCK, JL BURKE, MD TI DIAGNOSIS OF ECTOPIC PREGNANCY BY THE RATE OF INCREASE OF CHORIOGONADOTROPIN IN SERUM - DIAGNOSTIC-CRITERIA COMPARED SO CLINICAL CHEMISTRY LA English DT Article DE DATA HANDLING; RADIOIMMUNOASSAY; DISCRIMINANT ANALYSIS ID HUMAN CHORIONIC-GONADOTROPIN; HCG; INTRAUTERINE; GESTATION; ZONE AB We compare three methods for using the rate of change of human choriogonadotropin (hCG) concentration in serum to diagnose ectopic pregnancy. With Method I, the lower limit for the rate of increase of serum hCG in normal pregnancy is 66% per 48 h. With Method II, a different lower limit of normal is specified for each of four discrete sampling intervals of hCG. With Method III, the lower limit of normal is determined by a continuous discriminant function of the initial hCG concentration. If the initial hCG concentration is less-than-or-equal-to 2000 int. units/L (Second International Standard), all three methods have acceptable diagnostic efficiencies, and there are no statistically significant differences among conclusions from the methods. None of the three methods performs satisfactorily if the initial hCG concentration is > 2000 int. units/L. We recommend Method I because it is simpler than the other two. C1 SUNY STONY BROOK,DEPT PATHOL,STONY BROOK,NY 11794. RP EMANCIPATOR, K (reprint author), NIH,WARREN G MAGNUSON CLIN CTR,BLDG 10,ROOM 2C407,BETHESDA,MD 20892, USA. NR 23 TC 5 Z9 6 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD DEC PY 1990 VL 36 IS 12 BP 2097 EP 2101 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA EP614 UT WOS:A1990EP61400015 PM 2253352 ER PT J AU GUPTA, AK KIRCHNER, KA NICHOLSON, R ADAMS, JG SCHECHTER, AN NOGUCHI, CT STEINBERG, MH AF GUPTA, AK KIRCHNER, KA NICHOLSON, R ADAMS, JG SCHECHTER, AN NOGUCHI, CT STEINBERG, MH TI HYPOSTHENURIA IN SICKLE-CELL TRAIT (HBAS) CORRELATES WITH PERCENT HEMOGLOBIN S (HBS) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV MISSISSIPPI,MED CTR,JACKSON,MS 39216. VET ADM MED CTR,JACKSON,MS 39216. NIH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A985 EP A985 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900378 ER PT J AU LIGHTMAN, S BONDY, C LIGHTMAN, S KADOR, P AF LIGHTMAN, S BONDY, C LIGHTMAN, S KADOR, P TI ALDOSE REDUCTASE MESSENGER-RNA IN THE LENS EPITHELIUM INVIVO - EFFECTS OF DIABETES-MELLITUS AND GALACTOSEMIA SO CLINICAL SCIENCE LA English DT Article C1 NINCDS,NEUROCHEM LAB,BETHESDA,MD 20892. NEI,MOLEC PHARMACOL LAB,BETHESDA,MD 20892. CHARING CROSS & WESTMINSTER MED SCH,NEUROENDOCRINOL UNIT,LONDON,ENGLAND. RP LIGHTMAN, S (reprint author), MOORFIELDS EYE HOSP,INST OPHTHALMOL,CITY RD,LONDON EC1V 9PD,ENGLAND. NR 18 TC 13 Z9 13 U1 0 U2 1 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0143-5221 J9 CLIN SCI JI Clin. Sci. PD DEC PY 1990 VL 79 IS 6 BP 599 EP 603 PG 5 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EL908 UT WOS:A1990EL90800007 PM 2176946 ER PT J AU STERRITT, GR FREW, RA ROZIER, RG BRUNELLE, JA AF STERRITT, GR FREW, RA ROZIER, RG BRUNELLE, JA TI EVALUATION OF A SCHOOL-BASED FLUORIDE MOUTHRINSING AND CLINIC-BASED SEALANT PROGRAM ON A NONFLUORIDATED ISLAND SO COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY LA English DT Article C1 GOVT GUAM,DEPT PUBL HLTH & SOCIAL SERV,AGANA,GU. UNIV N CAROLINA,SCH PUBL HLTH,CHAPEL HILL,NC 27514. NIDR,EODPP,EPIDEMIOL BRANCH,BETHESDA,MD 20892. RP STERRITT, GR (reprint author), US PHS,REG 6,SUITE 1800,1200 MAIN TOWER BLDG,DALLAS,TX 75202, USA. NR 33 TC 13 Z9 13 U1 0 U2 2 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0301-5661 J9 COMMUNITY DENT ORAL JI Community Dentist. Oral Epidemiol. PD DEC PY 1990 VL 18 IS 6 BP 288 EP 293 DI 10.1111/j.1600-0528.1990.tb00082.x PG 6 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA EJ170 UT WOS:A1990EJ17000002 PM 2090379 ER PT J AU TANGREA, J EDWARDS, B HARTMAN, A TAYLOR, P PECK, G SALASCHE, S MENON, P WINTON, G MELLETTE, R GUILL, M ROBINSON, J GUIN, J STOLL, H AF TANGREA, J EDWARDS, B HARTMAN, A TAYLOR, P PECK, G SALASCHE, S MENON, P WINTON, G MELLETTE, R GUILL, M ROBINSON, J GUIN, J STOLL, H TI ISOTRETINOIN BASAL-CELL CARCINOMA PREVENTION TRIAL - DESIGN, RECRUITMENT RESULTS, AND BASE-LINE CHARACTERISTICS OF THE TRIAL PARTICIPANTS SO CONTROLLED CLINICAL TRIALS LA English DT Article DE CHEMOPREVENTION; ISOTRETINOIN; BASAL CELL CARCINOMA; DESIGN ID SERUM-VITAMIN-A; CLINICAL-TRIALS; RETINOIC ACID; 13-CIS-RETINOIC ACID; LUNG-CANCER; HYPEROSTOSIS; INHIBITION; THERAPY; RATS; DIFFERENTIATION AB The Isotretinoin-Basal Cell Carcinoma Prevention Trial (ISO-BCC study) is a double-masked, randomized, placebo controlled, multicenter clinical trial. It is the first intramural cancer chemoprevention trial sponsored by the Division of Cancer Prevention and Control of the National Cancer Institute. This trial was designed to evaluate the effectiveness of chronic administration of low dosage levels (10 mg) of a synthetic retinoid, isotretinoin, in reducing the incidence of basal cell carcinoma in a high-risk population and to determine the incidence and severity of side effects associated with this long-term treatment. Between 1984 and 1987, eight clinical centers enrolled 981 participants between the ages of 40 and 75, who had two or more biopsy proven basal cell carcinomas in the 5 years before trial entry. This article describes the trial design, recruitment results, and baseline characteristics of the participant population in the ISO-BCC Study. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. NORTHWESTERN UNIV,EVANSTON,IL 60201. UNIV ARKANSAS,FAYETTEVILLE,AR 72701. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. PORTSMOUTH NAVAL HOSP,PORTSMOUTH,VA. EISENHOWER ARMY MED CTR,FT GORDON,GA. RP TANGREA, J (reprint author), NCI,DIV CANC PREVENT & CONTROL,CANC PREVENT STUDIES BRANCH,EPN BLDG,BETHESDA,MD 20892, USA. NR 53 TC 14 Z9 14 U1 3 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0197-2456 J9 CONTROL CLIN TRIALS JI Controlled Clin. Trials PD DEC PY 1990 VL 11 IS 6 BP 433 EP 450 DI 10.1016/0197-2456(90)90020-3 PG 18 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA EQ652 UT WOS:A1990EQ65200005 PM 1963135 ER PT J AU Kennison, JA Tamkun, JW AF Kennison, J. A. Tamkun, J. W. TI Y Early Drosophila development SO CURRENT OPINION IN CELL BIOLOGY LA English DT Article C1 [Kennison, J. A.] NICHD, Mol Genet Lab, NIH, Bethesda, MD USA. Univ Calif Santa Cruz, Dept Biol, Santa Cruz, CA 95064 USA. RP Kennison, JA (reprint author), NICHD, Mol Genet Lab, NIH, Bethesda, MD USA. NR 22 TC 1 Z9 1 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0955-0674 EI 1879-0410 J9 CURR OPIN CELL BIOL JI Curr. Opin. Cell Biol. PD DEC PY 1990 VL 2 IS 6 BP 991 EP 995 DI 10.1016/0955-0674(90)90147-7 PG 5 WC Cell Biology SC Cell Biology GA V39FA UT WOS:000209395700006 PM 2099814 ER PT J AU OTTESEN, EA AF OTTESEN, EA TI ACTIVITY OF IVERMECTIN IN HUMAN PARASITIC INFECTIONS OTHER THAN ONCHOCERCIASIS SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Article RP OTTESEN, EA (reprint author), NIH,BETHESDA,MD 20892, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU CURRENT SCIENCE PI PHILADELPHIA PA 400 MARKET STREET,SUITE 750 ATTN:SARAH WHEALEN/SUB MGR, PHILADELPHIA, PA 19106 SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD DEC PY 1990 VL 3 IS 6 BP 834 EP 837 DI 10.1097/00001432-199012000-00016 PG 4 WC Infectious Diseases SC Infectious Diseases GA EQ079 UT WOS:A1990EQ07900016 ER PT J AU JOHNSTON, JG GERFEN, CR HABER, SN VANDERKOOY, D AF JOHNSTON, JG GERFEN, CR HABER, SN VANDERKOOY, D TI MECHANISMS OF STRIATAL PATTERN-FORMATION - CONSERVATION OF MAMMALIAN COMPARTMENTALIZATION SO DEVELOPMENTAL BRAIN RESEARCH LA English DT Article C1 NIH,NEUROPHYSIOL LAB,BETHESDA,MD 20892. UNIV ROCHESTER,DEPT NEUROBIOL & ANAT,ROCHESTER,NY 14627. RP JOHNSTON, JG (reprint author), UNIV TORONTO,DEPT ANAT,ENVIRONM SCI & FORESTRY RES GRP,MED SCI BLDG,TORONTO M5S 1A8,ONTARIO,CANADA. NR 52 TC 77 Z9 78 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-3806 J9 DEV BRAIN RES JI Dev. Brain Res. PD DEC 1 PY 1990 VL 57 IS 1 BP 93 EP 102 DI 10.1016/0165-3806(90)90189-6 PG 10 WC Developmental Biology; Neurosciences SC Developmental Biology; Neurosciences & Neurology GA EM790 UT WOS:A1990EM79000013 ER PT J AU WERNER, H SHENORR, Z STANNARD, B BURGUERA, B ROBERTS, CT LEROITH, D AF WERNER, H SHENORR, Z STANNARD, B BURGUERA, B ROBERTS, CT LEROITH, D TI EXPERIMENTAL DIABETES INCREASES INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II RECEPTOR CONCENTRATION AND GENE-EXPRESSION IN KIDNEY SO DIABETES LA English DT Article C1 NIDDKD,DIABET BRANCH,MOLEC & CELLULAR PHYSIOL SECT,BLDG 10,ROOM 8S243,9000 ROCKVILLE PIKE,BETHESDA,MD 20892. NR 50 TC 126 Z9 126 U1 0 U2 1 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0012-1797 J9 DIABETES JI Diabetes PD DEC PY 1990 VL 39 IS 12 BP 1490 EP 1497 DI 10.2337/diabetes.39.12.1490 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EK682 UT WOS:A1990EK68200006 PM 2174008 ER PT J AU WEINBERG, WC BROWN, PD STETLERSTEVENSON, WG YUSPA, SH AF WEINBERG, WC BROWN, PD STETLERSTEVENSON, WG YUSPA, SH TI GROWTH-FACTORS SPECIFICALLY ALTER HAIR FOLLICLE CELL-PROLIFERATION AND COLLAGENOLYTIC ACTIVITY ALONE OR IN COMBINATION SO DIFFERENTIATION LA English DT Article ID OUTER ROOT SHEATH; MOUSE SKIN; PLASMINOGEN ACTIVATORS; HUMAN KERATINOCYTES; EXPRESSION; IV; METALLOPROTEINASES; LOCALIZATION; CULTIVATION; INVITRO AB A three-dimensional culture model for isolated murine pelage hair follicles in a type I collagen gel has been utilized to study the effects of selected growth factors on follicle cell proliferation and release of collagenolytic factors. Cultured follicle organoids differentially express cytokeratins 6 and 14 in a pattern suggesting they contain cells of the outer root sheath, inner root sheath and follicle matrix. Using incorporation of [H-3]thymidine as a measure of proliferation, follicle organoids show a peak of DNA synthesis between day 1 and 5 of culture, depending on plating density, and then have a low rate of DNA synthesis. Thymidine incorporation is stimulated by transforming growth factor-alpha (TGF-alpha) in a dose-dependent response. Only peripheral cells presumably of the outer root sheath, incorporate thymidine in basal or stimulated conditions. TGF-beta-1 and TGF-beta-2 inhibit constitutive cell proliferation and oppose growth stimulation by TGF-alpha. Hair follicles lyse the collagen gel matrix when exposed to certain cytokines. Epidermal growth factor (EGF) and TGF-alpha stimulate gel lysis, but TGF-beta-1, TGF-beta-2 and cholera toxin do not. Other skin-derived cells, such as interfollicular epidermal cells, dermal fibroblasts, or combinations thereof, do not lyse gels in this culture model even when exposed to growth factors. Combinations of EGF or TGF-alpha with TGF-beta-1 or TGF-beta-2 are synergistic for collagenase release. These cytokines stimulate release of multiple species of matrix metalloproteinases, but the 92-kDa and 72 kDa type IV procollagenases and their activated derivatives predominate on zymograms. In cytokine-stimulated follicles, both peripheral and centrally located cells in the organoids express the 72-kDa type IV collagenase and a similar immunostaining pattern is present in developing follicles in vivo. Thus growth factors appear to work in concert for certain hair follicle responses and in opposition for others. These combined actions may play a role in different phases of hair follicle development that require cell replication and invasion into the deeper dermis. C1 NCI,DIV CANC ETIOL,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,BETHESDA,MD 20892. NCI,DIV CANC BIOL & DIAG,PATHOL LAB,BETHESDA,MD 20892. RI Weinberg, Wendy/A-8920-2009; Stetler-Stevenson, William/H-6956-2012 OI Stetler-Stevenson, William/0000-0002-5500-5808 NR 33 TC 48 Z9 48 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-4681 J9 DIFFERENTIATION JI Differentiation PD DEC PY 1990 VL 45 IS 3 BP 168 EP 178 DI 10.1111/j.1432-0436.1990.tb00470.x PG 11 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA EX939 UT WOS:A1990EX93900003 PM 1965309 ER PT J AU GONZALEZ, FJ LIU, SY KOZAK, CA NEBERT, DW AF GONZALEZ, FJ LIU, SY KOZAK, CA NEBERT, DW TI DECREASED HNF-1 GENE-EXPRESSION IN MICE HOMOZYGOUS FOR A 1.2-CENTIMORGAN DELETION ON CHROMOSOME-7 SO DNA AND CELL BIOLOGY LA English DT Article ID RIBONUCLEIC-ACID; NUCLEAR FACTOR; RAT; TRANSCRIPTION; PROMOTER; PROTEIN; DNA; STABILIZATION; P450IIE1; SEQUENCE AB The mammalian CYP2E1 gene encodes a cytochrome P450 enzyme that is markedly increased soon after birth. In vitro evidence suggests that the rat CYP2E1 gene is positively regulated by the transcription factor HNF-1 or a protein displaying DNA-binding properties similar to HNF-1. In contrast to newborn wild-type mice and mice heterozygous for a 1.2-centiMorgan deletion on chromosome 7, newborn mice homozygous for this deletion do not show significant expression of the Cyp2e-1 and Hnf-1 genes. However, the Cyp2e-1 and Hnf-1 structural genes are not in the chromosome 7 segment deleted in these mice. Although Cyp2e-1 maps to chromosome 7, it is distal to this deletion; Hnf-1 maps to chromosome 5. These data suggest that the deleted region of chromosome 7 contains a gene encoding a trans-acting factor which is upstream (epistatic) in the regulatory cascade that includes Hnf-1 gene expression. C1 UNIV CINCINNATI,MED CTR,INST ENVIRONM HLTH,DEPT ENVIRONM HLTH,KETTERING LAB,CINCINNATI,OH 45267. NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892. NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892. FU NIA NIH HHS [R01 AG09235] NR 38 TC 24 Z9 24 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1044-5498 J9 DNA CELL BIOL JI DNA Cell Biol. PD DEC PY 1990 VL 9 IS 10 BP 771 EP 776 DI 10.1089/dna.1990.9.771 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity GA ER453 UT WOS:A1990ER45300008 PM 2264930 ER PT J AU MAVROTHALASSITIS, G BEAL, G PAPAS, TS AF MAVROTHALASSITIS, G BEAL, G PAPAS, TS TI DEFINING TARGET SEQUENCES OF DNA-BINDING PROTEINS BY RANDOM SELECTION AND PCR - DETERMINATION OF THE GCN4 BINDING SEQUENCE REPERTOIRE SO DNA AND CELL BIOLOGY LA English DT Article ID TRANSCRIPTIONAL ACTIVATOR PROTEIN; YEAST; SITE AB We developed a simple and accurate method to define the sequence recognition properties of DNA-binding proteins. The method employs polymerase chain reaction (PCR) amplification of sequences selected from a mixture of random oligonucleotides by the gel mobility-shift assay. We used this method to define the sequence requirement of the binding domain of the yeast transcriptional activator GCN4. Using a total of 200 ng of purified protein and four cycles of binding and subsequent amplification, we identified the TGA-(C/G)TCA sequence as the binding consensus of GCN4, which is consistent with the previously reported recognition sequence. In addition, our data indicate that GCN4 can bind with lower affinity to sequences that differ from the optimal sequence in one or even two positions. The most common variation was the C to A at position +2. The majority of the substitutions that still allowed binding were 3' to the central C residue indicating that the two sides of the palindromic recognition sequence are not equivalent. C1 PROGRAM RESOURCES INC,NUCL ACID & PROT SYNTH LAB,FREDERICK,MD 21701. RP MAVROTHALASSITIS, G (reprint author), NCI,MOLEC ONCOL LAB,BLDG 469,ROOM 211,FREDERICK,MD 21701, USA. NR 10 TC 47 Z9 47 U1 0 U2 3 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1044-5498 J9 DNA CELL BIOL JI DNA Cell Biol. PD DEC PY 1990 VL 9 IS 10 BP 783 EP 788 DI 10.1089/dna.1990.9.783 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity GA ER453 UT WOS:A1990ER45300010 PM 2264932 ER PT J AU ZUCKER, DM AF ZUCKER, DM TI AN ANALYSIS OF VARIANCE PITFALL - THE FIXED EFFECTS ANALYSIS IN A NESTED DESIGN SO EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT LA English DT Article RP ZUCKER, DM (reprint author), NHLBI,DECA,BIOSTAT RES BRANCH,BETHESDA,MD 20892, USA. NR 8 TC 85 Z9 87 U1 0 U2 3 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0013-1644 J9 EDUC PSYCHOL MEAS JI Educ. Psychol. Meas. PD WIN PY 1990 VL 50 IS 4 BP 731 EP 738 DI 10.1177/0013164490504002 PG 8 WC Psychology, Educational; Mathematics, Interdisciplinary Applications; Psychology, Mathematical SC Psychology; Mathematics GA EM581 UT WOS:A1990EM58100002 ER PT J AU COHEN, RB BOAL, TR SAFER, B AF COHEN, RB BOAL, TR SAFER, B TI INCREASED ELF-2-ALPHA EXPRESSION IN MITOGEN-ACTIVATED PRIMARY LYMPHOCYTES-T SO EMBO JOURNAL LA English DT Article RP COHEN, RB (reprint author), NHLBI,PROT & RNA BIOSYNTH SECT,MOLEC HEMATOL LAB,BETHESDA,MD 20892, USA. NR 54 TC 46 Z9 47 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0261-4189 J9 EMBO J JI Embo J. PD DEC PY 1990 VL 9 IS 12 BP 3831 EP 3837 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EK538 UT WOS:A1990EK53800004 PM 1701139 ER PT J AU GOOSSEN, B CAUGHMAN, SW HARFORD, JB KLAUSNER, RD HENTZE, MW AF GOOSSEN, B CAUGHMAN, SW HARFORD, JB KLAUSNER, RD HENTZE, MW TI TRANSLATIONAL REPRESSION BY A COMPLEX BETWEEN THE IRON-RESPONSIVE ELEMENT OF FERRITIN MESSENGER-RNA AND ITS SPECIFIC CYTOPLASMIC-BINDING PROTEIN IS POSITION-DEPENDENT INVIVO SO EMBO JOURNAL LA English DT Article C1 NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892. NCI,DERMATOL BRANCH,BETHESDA,MD 20892. RP GOOSSEN, B (reprint author), EUROPEAN MOLEC BIOL LAB,MEYERHOFSTR 1,POSTFACH 102209,W-6900 HEIDELBERG 1,GERMANY. NR 48 TC 121 Z9 121 U1 0 U2 2 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0261-4189 J9 EMBO J JI Embo J. PD DEC PY 1990 VL 9 IS 12 BP 4127 EP 4133 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EK538 UT WOS:A1990EK53800038 PM 1701143 ER PT J AU PRIEL, E SHOWALTER, SD ROBERTS, M OROSZLAN, S SEGAL, S ABOUD, M BLAIR, DG AF PRIEL, E SHOWALTER, SD ROBERTS, M OROSZLAN, S SEGAL, S ABOUD, M BLAIR, DG TI TOPOISOMERASE-I ACTIVITY ASSOCIATED WITH HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PARTICLES AND EQUINE INFECTIOUS-ANEMIA VIRUS CORE SO EMBO JOURNAL LA English DT Article C1 PROGRAM RESOURCES INC,FREDERICK,MD 21702. NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,BIONET RES INC,FREDERICK,MD 21702. RP PRIEL, E (reprint author), BEN GURION UNIV NEGEV,FAC HLTH SCI,MICROBIOL & IMMUNOL UNIT,IL-84105 BEER SHEVA,ISRAEL. FU PHS HHS [N01-C0-74101] NR 33 TC 46 Z9 47 U1 0 U2 1 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0261-4189 J9 EMBO J JI Embo J. PD DEC PY 1990 VL 9 IS 12 BP 4167 EP 4172 PG 6 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EK538 UT WOS:A1990EK53800043 PM 2174357 ER PT J AU TAKAO, T TRACEY, DE MITCHELL, WM DESOUZA, EB AF TAKAO, T TRACEY, DE MITCHELL, WM DESOUZA, EB TI INTERLEUKIN-1 RECEPTORS IN MOUSE-BRAIN - CHARACTERIZATION AND NEURONAL LOCALIZATION SO ENDOCRINOLOGY LA English DT Article C1 NIDA,ADDICT RES CTR,NEUROBIOL LAB,BALTIMORE,MD 21224. UPJOHN CO,HYPERSENSIT DIS RES,KALAMAZOO,MI 49007. NR 54 TC 268 Z9 272 U1 0 U2 2 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 3070 EP 3078 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800059 PM 2147409 ER PT J AU ROKAEUS, A PRUSS, RM EIDEN, LE AF ROKAEUS, A PRUSS, RM EIDEN, LE TI GALANIN GENE-EXPRESSION IN CHROMAFFIN CELLS IS CONTROLLED BY CALCIUM AND PROTEIN-KINASE SIGNALING PATHWAYS SO ENDOCRINOLOGY LA English DT Article C1 NIMH,CELL BIOL LAB,MOLEC & CELLULAR NEUROBIOL UNIT,BLDG 36,ROOM 3A-17,BETHESDA,MD 20892. KAROLINSKA INST,MED NOBEL INST,DEPT BIOCHEM,S-10401 STOCKHOLM 60,SWEDEN. MERRELL DOW PHARMACEUT INC,CINCINNATI,OH 45215. OI Eiden, Lee/0000-0001-7524-944X NR 46 TC 41 Z9 41 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 3096 EP 3102 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800062 PM 1701135 ER PT J AU ROCCO, S AMBROZ, C AGUILERA, G AF ROCCO, S AMBROZ, C AGUILERA, G TI INTERACTION BETWEEN SEROTONIN AND OTHER REGULATORS OF ALDOSTERONE SECRETION IN RAT ADRENAL GLOMERULOSA CELLS SO ENDOCRINOLOGY LA English DT Article C1 NICHHD,DEV ENDOCRINOL BRANCH,ENDOCRINE PHYSIOL SECT,BLDG 10,ROOM 10N262,BETHESDA,MD 20892. NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892. NR 38 TC 20 Z9 20 U1 0 U2 2 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 3103 EP 3110 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800063 PM 2174345 ER PT J AU HERNANDEZ, ER ROBERTS, CT HURWITZ, A LEROITH, D ADASHI, EY AF HERNANDEZ, ER ROBERTS, CT HURWITZ, A LEROITH, D ADASHI, EY TI RAT OVARIAN INSULIN-LIKE GROWTH FACTOR-II GENE-EXPRESSION IS THECA-INTERSTITIAL CELL-EXCLUSIVE - HORMONAL-REGULATION AND RECEPTOR DISTRIBUTION SO ENDOCRINOLOGY LA English DT Note C1 UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201. NIDDK,DIABET BRANCH,MOLEC & CELLULAR PHYSIOL,BETHESDA,MD 20892. RP HERNANDEZ, ER (reprint author), UNIV MARYLAND,SCH MED,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,BALTIMORE,MD 21201, USA. OI Roberts, Charles/0000-0003-1756-5772 NR 22 TC 47 Z9 47 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 3249 EP 3251 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800084 PM 2174350 ER PT J AU GOERING, PL REHM, S AF GOERING, PL REHM, S TI INHIBITION OF LIVER, KIDNEY, AND ERYTHROCYTE DELTA-AMINOLEVULINIC-ACID DEHYDRATASE (PORPHOBILINOGEN SYNTHASE) BY GALLIUM IN THE RAT SO ENVIRONMENTAL RESEARCH LA English DT Article ID LEAD-BINDING PROTEIN; INDIUM CHLORIDE; TOXICITY; ZINC; METABOLISM; EXPOSURE; EXCRETION; ALUMINUM; ARSENIDE; TISSUES C1 NCI,FREDERICK CANC RES FACIL,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21701. RP GOERING, PL (reprint author), US FDA,CTR DEVICES & RADIOL HLTH,DIV LIFE SCI,OFF SCI & TECHNOL,ROCKVILLE,MD 20857, USA. NR 60 TC 10 Z9 10 U1 0 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD DEC PY 1990 VL 53 IS 2 BP 135 EP 151 DI 10.1016/S0013-9351(05)80115-X PG 17 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EP129 UT WOS:A1990EP12900003 PM 2253599 ER PT J AU GENDEK, EG BRODY, AR AF GENDEK, EG BRODY, AR TI CHANGES IN LIPID ORDERING OF MODEL PHOSPHOLIPID-MEMBRANES TREATED WITH CHRYSOTILE AND CROCIDOLITE ASBESTOS SO ENVIRONMENTAL RESEARCH LA English DT Article ID BLOOD-CELL MEMBRANES; SHORT-TERM EXPOSURE; SPIN-LABEL; ERYTHROCYTE-MEMBRANES; EPITHELIAL-CELLS; SIALIC-ACID; FIBERS; PEROXIDATION; INHIBITION; MECHANISM C1 NIEHS,PULM PATHOBIOL LAB,POB 12233,RES TRIANGLE PK,NC 27709. NR 48 TC 7 Z9 7 U1 2 U2 10 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD DEC PY 1990 VL 53 IS 2 BP 152 EP 167 DI 10.1016/S0013-9351(05)80116-1 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EP129 UT WOS:A1990EP12900004 PM 2174769 ER PT J AU HAYZER, DJ YOUNGCOOPER, GO MAGE, RG JATON, JC AF HAYZER, DJ YOUNGCOOPER, GO MAGE, RG JATON, JC TI CDNA CLONES ENCODING IMMUNOGLOBULIN-LAMBDA CHAINS FROM RABBIT EXPRESSING THE PHENOTYPE-C7 SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article ID LAMBDA-LIGHT CHAIN; VARIABLE-REGION GENES; LYMPHOCYTES-PRE-B; CONSTANT REGION; NUCLEOTIDE-SEQUENCE; BASILEA RABBITS; LOCUS; MOUSE; PSEUDOGENES; ORGANIZATION AB A cDNA library derived from spleen cells of an unimmunized rabbit expressing the c7 phenotype of Ig lambda chains (c7+,c21-) was screened with V-lambda or C-lambda probes of a lambda light chain bearing c21 epitopes. The nucleotide sequences of three hybridizing clones were found to be identical within the V-lambda, J-lambda and C-lambda regions. The V-lambda region was 97% similar to that of the functional germ-line gene V-lambda-2, and the C-lambda region was identical to that of gene C-lambda-6, recently identified. Gene C-lambda-6 exhibited four codon differences when compared with gene C-lambda-5, the latter encoding c21 epitopes. The data presented here and in the accompanying report (Jaton, J.-C. et al., Eur. J. Immunol. 1990.20:2713) support the view that gene C-lambda-6 encodes the C region of c7 lambda chains and that c7 and c21 markers designate two distinct isotypic forms of lambda chains. On the basis of comparative Southern blotting analyses and restriction maps of cloned genomic regions containing V-lambda and C-lambda genes, a scheme is proposed to account for the c7- and c21- phenotypes. C1 UNIV GENEVA,MED CTR,DEPT MED BIOCHEM,1 RUE MICHEL SERVET,CH-1211 GENEVA 4,SWITZERLAND. NIAID,IMMUNOL LAB,BETHESDA,MD 20892. NR 40 TC 5 Z9 5 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD DEC PY 1990 VL 20 IS 12 BP 2707 EP 2712 DI 10.1002/eji.1830201227 PG 6 WC Immunology SC Immunology GA EU724 UT WOS:A1990EU72400026 PM 2125274 ER PT J AU JATON, JC HAYZER, DJ FRUTIGER, S HUGHES, GJ YOUNGCOOPER, GO MAGE, RG AF JATON, JC HAYZER, DJ FRUTIGER, S HUGHES, GJ YOUNGCOOPER, GO MAGE, RG TI CHEMICAL AND IMMUNOCHEMICAL IDENTIFICATION OF THE 2ND MAJOR RABBIT IMMUNOGLOBULIN-LAMBDA CHAIN POLYPEPTIDE BEARING C7-EPITOPES SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article ID CONSTANT REGION; LAMBDA-CHAINS; GENES; CELLS AB The purification of lambda chain-containing IgG fraction from pooled sera of Basilea rabbits, which were bred and selected for the expression of a high level of lambda chains positive for c7 but negative for c21, was carried out. On the basis of specific binding to anti-c7 antiserum, the c7 lambda chain fraction in serum IgG was shown to account for up to 70% of the total immunoglobulin light chains, the remaining 30%, bearing the expected k2 bas isotype. Peptide mapping of the mixed light chains (lambda + k2 bas) followed by microsequencing of the constant region fragments indicated that the C-lambda region originated from the cDNA sequence derived from a c7+,c21- Basilea rabbit (i.e. identical to gene C-lambda-6), as described in the preceding report (Hayzer, D. J. et al., Eur. J. Immunol. 1990. 20:2707). In addition, a synthetic peptide encompassing residues 139-159 of the constant region derived from the predicted sequence of gene C-lambda-6 was shown to partially inhibit the c7-anti-c7 binding reaction in a sensitive enzyme-linked immunosorbent assay. Taken together, the chemical and immunochemical data clearly demonstrate that gene C-lambda-6 indeed encodes c7 epitopes. C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892. RP JATON, JC (reprint author), UNIV GENEVA,MED CTR,DEPT MED BIOCHEM,1 RUE MICHEL SERVET,CH-1211 GENEVA 4,SWITZERLAND. NR 24 TC 2 Z9 2 U1 1 U2 1 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD DEC PY 1990 VL 20 IS 12 BP 2713 EP 2718 DI 10.1002/eji.1830201228 PG 6 WC Immunology SC Immunology GA EU724 UT WOS:A1990EU72400027 PM 1702725 ER PT J AU HOLMES, KL MORSE, HC MAKINO, M HARDY, RR HAYAKAWA, K AF HOLMES, KL MORSE, HC MAKINO, M HARDY, RR HAYAKAWA, K TI A UNIQUE SUBSET OF NORMAL MURINE CD4+ T-CELLS LACKING THY-1 IS EXPANDED IN A MURINE RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME, MAIDS SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article ID INTRAEPITHELIAL LYMPHOCYTES; HEMATOPOIETIC-CELLS; B-CELL; PRE-B; EXPRESSION; DIFFERENTIATION; INDUCTION; ANTIGEN; MARROW AB Some strains of mice inoculated with LP-BM5 murine leukemia virus (MuLV) develop a syndrome, termed mouse acquired immunodeficiency syndrome (MAIDS), characterized by progressive lymphoproliferation and profound immunodeficiency. LP-BM5 MuLV is a virus mixture that contains ecotropic (eco) and mink cell focus-induced MuLV and a defective genome that is the proximal cause of disease. Flow cytometry analyses of spleen and lymph nodes from susceptible C57BL/6 mice infected with this virus mixture revealed the presence in spleen and peripheral lymph nodes of a previously unrecognized subset of CD4+CD3+ T cells that are Thy-1-. The frequency of these cells increased with progression of disease, eventually comprising between 30% and 50% of all CD4+ cells. Infection of A/J mice, a strain which is genetically resistant to development of MAIDS, did not induce an increase of this T cell population, indicating that infection with the virus mixture was insufficient to induce its proliferation. A central role for the defective virus in this process was suggested by the finding that C57BL/6 mice infected with LP-BM5 eco alone did not have increased frequencies of Thy-1-CD4+ cells in spleen. Studies of spleen and peripheral lymph node cells from normal mice demonstrated the presence of Thy-1-CD4+ cells at frequencies of 1%-2%. Studies using two anti-T cell monoclonal antibodies, SM6C10 and SM3G11, that define four CD4+ subsets showed that Thy-1-CD4+ T cells from normal and infected mice were present only in the 6C10- subsets. C1 NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892. FOX CHASE CANC INST,INST CANC RES,PHILADELPHIA,PA 19111. RP HOLMES, KL (reprint author), NIAID,BIOL RESOURCES BRANCH,BLDG 7,ROOM 301,BETHESDA,MD 20892, USA. OI Morse, Herbert/0000-0002-9331-3705 FU NCI NIH HHS [CA 06927]; NIAID NIH HHS [N01-AI-72622]; PHS HHS [RTR-05539] NR 21 TC 57 Z9 57 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD DEC PY 1990 VL 20 IS 12 BP 2783 EP 2787 DI 10.1002/eji.1830201237 PG 5 WC Immunology SC Immunology GA EU724 UT WOS:A1990EU72400036 PM 1980114 ER PT J AU FLANNERY, JG ODAY, W PFEFFER, BA HORWITZ, J BOK, D AF FLANNERY, JG ODAY, W PFEFFER, BA HORWITZ, J BOK, D TI UPTAKE, PROCESSING AND RELEASE OF RETINOIDS BY CULTURED HUMAN RETINAL-PIGMENT EPITHELIUM SO EXPERIMENTAL EYE RESEARCH LA English DT Article C1 NEI,PATHOPHYSIOL SECT,MECH OCULAR DIS LAB,BETHESDA,MD 20892. UNIV CALIF LOS ANGELES,SCH MED,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024. RP FLANNERY, JG (reprint author), UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,100 STEIN PLAZA,LOS ANGELES,CA 90024, USA. FU NEI NIH HHS [EY05624, EY0044, EY00331] NR 51 TC 56 Z9 56 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0014-4835 J9 EXP EYE RES JI Exp. Eye Res. PD DEC PY 1990 VL 51 IS 6 BP 717 EP 728 DI 10.1016/0014-4835(90)90057-2 PG 12 WC Ophthalmology SC Ophthalmology GA EL662 UT WOS:A1990EL66200012 PM 2265683 ER PT J AU RESHEF, E SEGARS, JH HILL, GA PRIDHAM, DD YUSSMAN, MA WENTZ, AC AF RESHEF, E SEGARS, JH HILL, GA PRIDHAM, DD YUSSMAN, MA WENTZ, AC TI ENDOMETRIAL INADEQUACY AFTER TREATMENT WITH HUMAN MENOPAUSAL GONADOTROPIN HUMAN CHORIONIC-GONADOTROPIN SO FERTILITY AND STERILITY LA English DT Article C1 UNIV LOUISVILLE,SCH MED,DEPT OBSTET & GYNECOL,550 JACKSON ST,LOUISVILLE,KY 40292. NIMH,DEV MOLEC IMMUN LAB,BETHESDA,MD 20892. VANDERBILT UNIV,DEPT OBSTET & GYNECOL,NASHVILLE,TN 37240. NORTHWESTERN UNIV,SCH MED,DEPT OBSTET & GYNECOL,CHICAGO,IL 60611. NR 12 TC 8 Z9 8 U1 0 U2 0 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD DEC PY 1990 VL 54 IS 6 BP 1012 EP 1016 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA EM361 UT WOS:A1990EM36100010 PM 2123159 ER PT J AU MORGAN, DL BUCHER, JR ELWELL, MR LILJA, HS MURTHY, ASK AF MORGAN, DL BUCHER, JR ELWELL, MR LILJA, HS MURTHY, ASK TI COMPARATIVE TOXICITY OF ETHYLENE DICHLORIDE IN F344/N, SPRAGUE-DAWLEY AND OSBORNE-MENDEL RATS SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article AB Studies were conducted to compare the toxicity of ethylene dichloride (EDC) in F344/N rats, Sprague-Dawley rats, and Osborne-Mendel rats. Ten rats/sex/group were exposed to EDC in drinking-water at 0, 500, 1000, 2000, 4000 and 8000 ppm for 13 wk. The highest concentration was limited by the maximum solubility of EDC in water (about 9000 ppm). In addition, F344/N rats (10/sex/group) were administered EDC in corn oil by gavage to compare toxicity resulting from bolus administration with that of continuous exposure in drinking-water. Gavage doses of EDC were within the range of total daily doses (in mg/kg body weight/day) resulting from exposure in drinking-water. EDC administered by gavage resulted in greater toxicity to F344/N rates than did administration of similar doses in drinking-water. All males receiving 240 and 480 mg/kg body weight and 9/10 females receiving 300 mg/kg body weight by gavage died before the end of the study. Necrosis of the cerebellum was observed in the brains of 3 males receiving 240 mg/kg body weight and 3 females receiving 300 mg/kg body weight. Hyperplasia and inflammation of the forestomach mucosa were observed in 8 male and 3 female rats that died or were killed in moribund condition. EDC caused minimal toxicity to F344/N, Sprague-Dawley and Osborne-Mendel rats at the drinking-water concentrations used in these studies; only female F344/N rats had EDC-related renal lesions. Based on mortality and EDC-related lesions, the no-effect levels for EDC administered by gavage to F344/N rats were 120 mg/kg body weight for males and 150 mg/kg body weight for females. C1 EG & G MASON RES INST,WORCESTER,MA 01608. RP MORGAN, DL (reprint author), NIEHS,MD-14-08,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 24 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0278-6915 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD DEC PY 1990 VL 28 IS 12 BP 839 EP 845 DI 10.1016/0278-6915(90)90057-T PG 7 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA EV595 UT WOS:A1990EV59500007 PM 2276705 ER PT J AU CHIANG, HCV ODORISIO, TM HUANG, SC MATON, PN GARDNER, JD JENSEN, RT AF CHIANG, HCV ODORISIO, TM HUANG, SC MATON, PN GARDNER, JD JENSEN, RT TI MULTIPLE HORMONE ELEVATIONS IN ZOLLINGER-ELLISON SYNDROME - PROSPECTIVE-STUDY OF CLINICAL-SIGNIFICANCE AND OF THE DEVELOPMENT OF A 2ND SYMPTOMATIC PANCREATIC ENDOCRINE TUMOR SYNDROME SO GASTROENTEROLOGY LA English DT Article C1 NIDDKD,DIGEST DIS BRANCH,BLDG 10,ROOM 9C-103,BETHESDA,MD 20892. OHIO STATE UNIV,COLL MED,DEPT MED,COLUMBUS,OH 43210. NR 54 TC 38 Z9 38 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 1990 VL 99 IS 6 BP 1565 EP 1575 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EH361 UT WOS:A1990EH36100003 PM 2227272 ER PT J AU FRUCHT, H NORTON, JA LONDON, JF VINAYEK, R DOPPMAN, JL GARDNER, JD JENSEN, RT MATON, PN AF FRUCHT, H NORTON, JA LONDON, JF VINAYEK, R DOPPMAN, JL GARDNER, JD JENSEN, RT MATON, PN TI DETECTION OF DUODENAL GASTRINOMAS BY OPERATIVE ENDOSCOPIC TRANSILLUMINATION - A PROSPECTIVE-STUDY SO GASTROENTEROLOGY LA English DT Article C1 NCI,SURG BRANCH,BETHESDA,MD 20892. NIH,CTR CLIN,BETHESDA,MD 20892. NIDDKD,DIGEST DIS BRANCH,BETHESDA,MD 20892. NR 37 TC 97 Z9 98 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 1990 VL 99 IS 6 BP 1622 EP 1627 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EH361 UT WOS:A1990EH36100010 PM 2227278 ER PT J AU MATON, PN JENSEN, RT AF MATON, PN JENSEN, RT TI REFLUX ESOPHAGITIS IN ZOLLINGER-ELLISON SYNDROME - REPLY SO GASTROENTEROLOGY LA English DT Letter RP MATON, PN (reprint author), NCI,DIGEST DIS BRANCH,ROOM 9C-103 BLDG 10,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 1990 VL 99 IS 6 BP 1858 EP 1858 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EH361 UT WOS:A1990EH36100053 ER PT J AU TRUN, NJ GOTTESMAN, S AF TRUN, NJ GOTTESMAN, S TI ON THE BACTERIAL-CELL CYCLE - ESCHERICHIA-COLI MUTANTS WITH ALTERED PLOIDY SO GENES & DEVELOPMENT LA English DT Article RP TRUN, NJ (reprint author), NCI,MOLEC BIOL LAB,BETHESDA,MD 20892, USA. NR 42 TC 25 Z9 25 U1 0 U2 0 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 0890-9369 J9 GENE DEV JI Genes Dev. PD DEC PY 1990 VL 4 IS 12A BP 2036 EP 2047 DI 10.1101/gad.4.12a.2036 PG 12 WC Cell Biology; Developmental Biology; Genetics & Heredity SC Cell Biology; Developmental Biology; Genetics & Heredity GA EN026 UT WOS:A1990EN02600002 PM 2176633 ER PT J AU AQUADRO, CF TACHIDA, H LANGLEY, CH HARADA, K MUKAI, T AF AQUADRO, CF TACHIDA, H LANGLEY, CH HARADA, K MUKAI, T TI INCREASED VARIATION IN ADH ENZYME-ACTIVITY IN DROSOPHILA MUTATION-ACCUMULATION EXPERIMENT IS NOT DUE TO TRANSPOSABLE ELEMENTS AT THE ADH STRUCTURAL GENE SO GENETICS LA English DT Article C1 NIEHS,GENET LAB,RES TRIANGLE PK,NC 27709. N CAROLINA STATE UNIV,DEPT STAT,RALEIGH,NC 27695. KYUSHU UNIV,DEPT BIOL,FUKUOKA 812,JAPAN. FU NIGMS NIH HHS [GM11546, R01 GM036431, GM36431] NR 33 TC 8 Z9 8 U1 0 U2 1 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 SN 0016-6731 J9 GENETICS JI Genetics PD DEC PY 1990 VL 126 IS 4 BP 915 EP 919 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA EL334 UT WOS:A1990EL33400012 PM 1963870 ER PT J AU LANGE, BW LANGLEY, CH STEPHAN, W AF LANGE, BW LANGLEY, CH STEPHAN, W TI MOLECULAR EVOLUTION OF DROSOPHILA METALLOTHIONEIN GENES SO GENETICS LA English DT Article C1 NIEHS, MOLEC GENET LAB, RES TRIANGLE PK, NC 27709 USA. NIEHS, DEPT ZOOL, RES TRIANGLE PK, NC 27709 USA. NIEHS, UNIV PROGRAM GENET, RES TRIANGLE PK, NC 27709 USA. NR 39 TC 50 Z9 53 U1 0 U2 4 PU GENETICS SOC AM PI BETHESDA PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA SN 0016-6731 J9 GENETICS JI Genetics PD DEC PY 1990 VL 126 IS 4 BP 921 EP 932 PG 12 WC Genetics & Heredity SC Genetics & Heredity GA EL334 UT WOS:A1990EL33400013 PM 1981765 ER PT J AU VOELKER, RA GRAVES, J GIBSON, W EISENBERG, M AF VOELKER, RA GRAVES, J GIBSON, W EISENBERG, M TI MOBILE ELEMENT INSERTIONS CAUSING MUTATIONS IN THE DROSOPHILA SUPPRESSOR OF SABLE LOCUS OCCUR IN DNASE-I HYPERSENSITIVE SUBREGIONS OF 5'-TRANSCRIBED NONTRANSLATED SEQUENCES SO GENETICS LA English DT Article RP VOELKER, RA (reprint author), NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709, USA. NR 42 TC 26 Z9 27 U1 0 U2 0 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 SN 0016-6731 J9 GENETICS JI Genetics PD DEC PY 1990 VL 126 IS 4 BP 1071 EP 1082 PG 12 WC Genetics & Heredity SC Genetics & Heredity GA EL334 UT WOS:A1990EL33400024 PM 1963868 ER PT J AU HOSOE, S BRAUCH, H LATIF, F GLENN, G DANIEL, L BALE, S CHOYKE, P GORIN, M OLDFIELD, E BERMAN, A GOODMAN, J ORCUTT, ML HAMPSCH, K DELISIO, J MODI, W MCBRIDE, W ANGLARD, P WEISS, G WALTHER, MM LINEHAN, WM LERMAN, MI ZBAR, B AF HOSOE, S BRAUCH, H LATIF, F GLENN, G DANIEL, L BALE, S CHOYKE, P GORIN, M OLDFIELD, E BERMAN, A GOODMAN, J ORCUTT, ML HAMPSCH, K DELISIO, J MODI, W MCBRIDE, W ANGLARD, P WEISS, G WALTHER, MM LINEHAN, WM LERMAN, MI ZBAR, B TI LOCALIZATION OF THE VONHIPPEL-LINDAU DISEASE GENE TO A SMALL REGION OF CHROMOSOME-3 SO GENOMICS LA English DT Article C1 NCI,FREDERICK CANC RES & DEV FACIL IMMUNOBIOL LAB,BLDG 560,ROOM 12-71,FREDERICK,MD 21701. NCI,ENVIRONM EPIDEMIOL BRANCH,BETHESDA,MD 20892. NEI,CTR CLIN,DEPT DIAGNOST RADIOL,BETHESDA,MD 20892. NEI,CLIN BRANCH,BETHESDA,MD 20892. NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892. NINCDS,CTR CLIN,DEPT NURSING,BETHESDA,MD 20892. PROGRAM RESOURCES INC,FREDERICK,MD 21701. NCI,BIOCHEM LAB,BETHESDA,MD 20892. NCI,SURG BRANCH,BETHESDA,MD 20892. NR 36 TC 128 Z9 130 U1 1 U2 5 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0888-7543 J9 GENOMICS JI Genomics PD DEC PY 1990 VL 8 IS 4 BP 634 EP 640 DI 10.1016/0888-7543(90)90249-T PG 7 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EL475 UT WOS:A1990EL47500004 PM 2276737 ER PT J AU GEJMAN, PV DETERAWADLEIGH, S MARTINEZ, MM BERRETTINI, WH GOLDIN, LR GELERNTER, J HSIEH, WT GERSHON, ES AF GEJMAN, PV DETERAWADLEIGH, S MARTINEZ, MM BERRETTINI, WH GOLDIN, LR GELERNTER, J HSIEH, WT GERSHON, ES TI MANIC-DEPRESSIVE ILLNESS NOT LINKED TO FACTOR-IX REGION IN AN INDEPENDENT SERIES OF PEDIGREES SO GENOMICS LA English DT Article C1 YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06520. RP GEJMAN, PV (reprint author), NIMH,CLIN NEUROGENET BRANCH,BETHESDA,MD 20892, USA. RI Martinez, Maria/B-3111-2013 OI Martinez, Maria/0000-0003-2180-4537 NR 31 TC 47 Z9 47 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0888-7543 J9 GENOMICS JI Genomics PD DEC PY 1990 VL 8 IS 4 BP 648 EP 655 DI 10.1016/0888-7543(90)90251-O PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EL475 UT WOS:A1990EL47500006 PM 1980485 ER PT J AU DANCIGER, M KOZAK, CA NICKERSON, J REDMOND, TM FARBER, DB AF DANCIGER, M KOZAK, CA NICKERSON, J REDMOND, TM FARBER, DB TI LOCALIZATION OF THE GENE FOR INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN TO MOUSE CHROMOSOME 14 NEAR NP-1 SO GENOMICS LA English DT Note C1 UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,B-237,LOS ANGELES,CA 90024. LOYOLA MARYMOUNT UNIV,LOS ANGELES,CA 90045. NIAID,BETHESDA,MD 20892. NEI,BETHESDA,MD 20892. OI Redmond, T. Michael/0000-0002-1813-5291 FU NEI NIH HHS [EY 00331, EY 02651, EY 08285] NR 43 TC 15 Z9 17 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0888-7543 J9 GENOMICS JI Genomics PD DEC PY 1990 VL 8 IS 4 BP 727 EP 731 DI 10.1016/0888-7543(90)90262-S PG 5 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EL475 UT WOS:A1990EL47500017 PM 2276745 ER PT J AU LUBIN, JH SAMET, JM WEINBERG, C AF LUBIN, JH SAMET, JM WEINBERG, C TI DESIGN ISSUES IN EPIDEMIOLOGIC STUDIES OF INDOOR EXPOSURE TO RN AND RISK OF LUNG-CANCER SO HEALTH PHYSICS LA English DT Article C1 UNIV NEW MEXICO, MED CTR, CTR CANC, NEW MEXICO TUMOR REGISTRY, ALBUQUERQUE, NM 87131 USA. UNIV NEW MEXICO, DEPT MED, ALBUQUERQUE, NM 87131 USA. NIEHS, DIV BIOMETRY & RISK ASSESSMENT, RES TRIANGLE PK, NC 27709 USA. RP LUBIN, JH (reprint author), NCI, EPIDEMIOL & BIOSTAT PROGRAM, EPIDEMIOL METHODS SECT, 6130 EXECUT BLVD RM 403, BETHESDA, MD 20892 USA. NR 43 TC 82 Z9 84 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD DEC PY 1990 VL 59 IS 6 BP 807 EP 817 DI 10.1097/00004032-199012000-00004 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA EK935 UT WOS:A1990EK93500005 PM 2228608 ER PT J AU SALIVE, ME MAYFIELD, JA WEISSMAN, NW AF SALIVE, ME MAYFIELD, JA WEISSMAN, NW TI PATIENT OUTCOMES RESEARCH TEAMS AND THE AGENCY FOR HEALTH-CARE POLICY AND RESEARCH SO HEALTH SERVICES RESEARCH LA English DT Article ID TRANS-URETHRAL RESECTION; MEDICAL-CARE; GEOGRAPHIC VARIATIONS; QUALITY ASSESSMENT; DATA-BASES; PROSTATECTOMY; ASSURANCE; SERVICES RP SALIVE, ME (reprint author), NIH,NATL INST AGING,DEMOG & BIOMETRY PROGRAM,7550 WISCONSIN AVE,BETHESDA,MD 20892, USA. NR 42 TC 50 Z9 51 U1 3 U2 3 PU HEALTH ADMINISTRATION PRESS PI MELROSE PARK PA C/O FOUNDATION AMER COLL HEALTHCARE EXECUTIVES 1951 CORNELL AVE, MELROSE PARK, IL 60160 SN 0017-9124 J9 HEALTH SERV RES JI Health Serv. Res. PD DEC PY 1990 VL 25 IS 5 BP 697 EP 708 PG 12 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA EP327 UT WOS:A1990EP32700002 PM 2254084 ER PT J AU LINNOILA, I AF LINNOILA, I TI PATHOLOGY OF NON-SMALL-CELL LUNG-CANCER - NEW DIAGNOSTIC APPROACHES SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Review RP LINNOILA, I (reprint author), USN HOSP,NCI,MED ONCOL BRANCH,BLDG 8,ROOM 5101,BETHESDA,MD 20814, USA. NR 144 TC 36 Z9 37 U1 0 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD DEC PY 1990 VL 4 IS 6 BP 1027 EP 1051 PG 25 WC Oncology; Hematology SC Oncology; Hematology GA EL331 UT WOS:A1990EL33100002 PM 1962774 ER PT J AU ANDERSON, WF AF ANDERSON, WF TI SEPTEMBER 14, 1990 - THE BEGINNING SO HUMAN GENE THERAPY LA English DT Editorial Material RP ANDERSON, WF (reprint author), NHLBI,MOLEC HEMATOL BRANCH,BLDG 10,7D-18,BETHESDA,MD 20892, USA. NR 6 TC 36 Z9 36 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD WIN PY 1990 VL 1 IS 4 BP 371 EP 372 DI 10.1089/hum.1990.1.4-371 PG 2 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA EW285 UT WOS:A1990EW28500001 PM 1981846 ER PT J AU AEBERSOLD, P KASID, A ROSENBERG, SA AF AEBERSOLD, P KASID, A ROSENBERG, SA TI SELECTION OF GENE-MARKED TUMOR INFILTRATING LYMPHOCYTES FROM POSTTREATMENT BIOPSIES - A CASE-STUDY SO HUMAN GENE THERAPY LA English DT Article ID IMMUNOTHERAPY; INTERLEUKIN-2 AB Patients with malignant melanoma have been treated with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes (TIL) marked by retroviral gene transduction. The retroviral vector contained a gene coding for the bacterial enzyme neomycin phosphotransferase, such that transduced TIL expressing the enzyme could survive otherwise toxic concentrations of the neomycin analogue G418. For 1 patient, who exhibited a complete regression of cancer after treatment with TIL, lymphocytes from post-treatment blood and tumor biopsies were cultured in IL-2, and transduced TIL were recovered by G418 selection. Analysis of T-cell receptor heterogeneity indicated that the transduced TIL recovered from the tumor biopsy were different from TIL that were kept strictly in vitro and selected in G418. The selection process required weeks in culture, during which time control cultures changed radically in subset composition, so there was also a simultaneous selection for long-term in vitro growth advantage. It cannot be certain that the TIL subsets preferentially recovered from the tumor biopsy corresponded to those that mediated complete elimination of tumor in this patient. RP AEBERSOLD, P (reprint author), NCI,SURG BRANCH,BLDG 10,ROOM 2B12,BETHESDA,MD 20892, USA. NR 11 TC 21 Z9 21 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD WIN PY 1990 VL 1 IS 4 BP 373 EP 384 DI 10.1089/hum.1990.1.4-373 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA EW285 UT WOS:A1990EW28500002 PM 1964094 ER PT J AU CULVER, KW MORGAN, RA OSBORNE, WRA LEE, RT LENSCHOW, D ABLE, C CORNETTA, K ANDERSON, WF BLAESE, RM AF CULVER, KW MORGAN, RA OSBORNE, WRA LEE, RT LENSCHOW, D ABLE, C CORNETTA, K ANDERSON, WF BLAESE, RM TI INVIVO EXPRESSION AND SURVIVAL OF GENE-MODIFIED LYMPHOCYTES-T IN RHESUS-MONKEYS SO HUMAN GENE THERAPY LA English DT Article ID HUMAN ADENOSINE-DEAMINASE; CELL-LINES; RESTRICTION; SEQUENCES; THERAPY AB Lymphocytes can be readily transduced with retroviral vectors and the gene-modified lymphocytes will stably express the inserted genes in vitro for long periods. As a prelude to studies in humans, we evaluated the survival of gene-modified T lymphocytes and the expression of the introduced genes in nonhuman primate T lymphocytes both in vitro and in vivo to determine if lymphocytes could be a potential cellular gene therapy vehicle. Rhesus peripheral blood T-lymphocytes and/or lymph node lymphocytes were transduced with a retroviral vector that contained a bacterial neomycin resistance (NeoR) gene or both NeoR and the human adenosine deaminase (hADA) genes. The cells were then selected for NeoR expression by growth in the neomycin analogue G418 and the autologous gene-modified T cells were reintroduced into the donor animals. T lymphocytes were periodically regrown from the blood and selected in G418. Gene-modified cells persisted in 1 animal for 727 days as detected by analysis for vector DNA by polymerase chain reaction (PCR). Evidence for expression of the human ADA or NeoR genes has also been detected up to 727 days after cell infusion. These findings suggest that gene-modified T lymphocytes can survive and circulate for long periods in vivo and can continue to express the introduced genes. C1 NCI,METAB BRANCH,CELLULAR IMMUNOL SECT,BLDG 10,ROOM 6B05,BETHESDA,MD 20892. NHLBI,MOLEC HEMATOL BRANCH,BETHESDA,MD 20892. UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195. NR 21 TC 53 Z9 53 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD WIN PY 1990 VL 1 IS 4 BP 399 EP 410 DI 10.1089/hum.1990.1.4-399 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA EW285 UT WOS:A1990EW28500004 PM 1964096 ER PT J AU JUENGST, ET AF JUENGST, ET TI THE NIH POINTS TO CONSIDER AND THE LIMITS OF HUMAN GENE-THERAPY SO HUMAN GENE THERAPY LA English DT Article AB In this essay, I examine the sources and reach of the NIH "Points to Consider." These guidelines are based on normative considerations inherited from two sets of science policy deliberations that took place in the United States during the 1970s: the discussion of research with human subjects and the recombinant DNA debate. The combined lessons of those deliberations provide six criteria by which to evaluate human gene therapy proposals. While these criteria could be used to reject proposals to attempt germ-line gene therapy or enhancement engineering today, they provide no principled basis for publicly proscribing the development of these forms of genetic intervention. Instead, they will ultimately lead us to approach the moral limits of gene therapy as a professional policy question about the goals of medicine, rather than as a social policy question about the public good. C1 NIH,NATL CTR HUMAN GENOME RES,HUMAN GENOME PROGRAM,ETH OFF,BETHESDA,MD 20892. OI Juengst, Eric/0000-0002-8374-5774 NR 41 TC 13 Z9 13 U1 1 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD WIN PY 1990 VL 1 IS 4 BP 425 EP 433 DI 10.1089/hum.1990.1.4-425 PG 9 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA EW285 UT WOS:A1990EW28500007 PM 2078585 ER PT J AU FUJIWARA, S KOIZUMI, S FISHER, RJ BHAT, NK PAPAS, TS AF FUJIWARA, S KOIZUMI, S FISHER, RJ BHAT, NK PAPAS, TS TI MONOCLONAL-ANTIBODIES SPECIFIC TO HUMAN ETS-2 ONCOPROTEIN - RECOGNITION OF EPITOPES CLUSTERED ON THE B-DOMAIN SO HYBRIDOMA LA English DT Article ID TRANSFORMING GENE; PROTO-ONCOGENE; PROTEINS; PRODUCTS; CHROMOSOME-21; PROTOONCOGENE; EXPRESSION; SEQUENCE; VIRUS AB Six monoclonal antibodies were prepared from mice immunized with a bacterially expressed human ets-2 protein. These antibodies specifically recognize the two human ets-2-encoded proteins p56 and p54 but failed to react with chicken, mouse, rat, bovine, or monkey proteins, suggesting that the antibodies recognize epitopes specific to the human ets-2 protein. Differential reactivities of these monoclonal antibodies with the peptide fragments generated by partial proteolytic digestion of the bacterially expressed ets-2 protein indicated that the six antibodies recognize at least three distinct epitopes in the B domain of the ets-2 protein. Immunoprecipitation experiments comparing native and denaturing conditions suggested that the ets-2 domain detected by the monoclonal antibodies is masked in the native condition by either protein folding or interacting proteins. The biochemical analysis of the ets-2 protein will be facilitated by the development of these monoclonal antibodies, which may be useful as both domain-specific probes and tools for specifically detecting the human ets-2 protein in heterologous expression systems. C1 PROGRAM RESOURCES INC,FREDERICK,MD. RP FUJIWARA, S (reprint author), NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701, USA. RI Fisher, Robert/B-1431-2009 NR 23 TC 8 Z9 8 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0272-457X J9 HYBRIDOMA JI Hybridoma PD DEC PY 1990 VL 9 IS 6 BP 559 EP 571 DI 10.1089/hyb.1990.9.559 PG 13 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA ER303 UT WOS:A1990ER30300004 PM 1706313 ER PT J AU GARCIAPEREZ, A BURG, MB AF GARCIAPEREZ, A BURG, MB TI IMPORTANCE OF ORGANIC OSMOLYTES FOR OSMOREGULATION BY RENAL MEDULLARY CELLS SO HYPERTENSION LA English DT Review C1 NHLBI,KIDNEY & ELECTROLYTE METAB LAB,BLDG 10,ROOM 6N307,BETHESDA,MD 20892. NR 53 TC 59 Z9 60 U1 0 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0194-911X J9 HYPERTENSION JI Hypertension PD DEC PY 1990 VL 16 IS 6 BP 595 EP 602 PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EM595 UT WOS:A1990EM59500001 PM 2246026 ER PT J AU HASLOV, KR FAUNTLEROY, MB STASHAK, PW TAYLOR, CE BAKER, PJ AF HASLOV, KR FAUNTLEROY, MB STASHAK, PW TAYLOR, CE BAKER, PJ TI T-CELLS REGULATE THE IGM ANTIBODY-RESPONSE OF BALB/C MICE TO DEXTRAN B1355 SO IMMUNOBIOLOGY LA English DT Article ID III PNEUMOCOCCAL POLYSACCHARIDE; LOW-DOSE PARALYSIS; INDEPENDENT ANTIGEN ALPHA(1->3)DEXTRAN; PLAQUE-FORMING CELLS; B-CELLS; IMMUNE-RESPONSE; CONCANAVALIN-A; IMMUNOLOGICAL-UNRESPONSIVENESS; BACTERIAL LIPOPOLYSACCHARIDES; CAPSULAR POLYSACCHARIDE AB The IgM antibody response of BALB/c mice to bacterial (Leuconostoc) dextran B1355 is influenced in a positive and negative manner by regulatory CD4+ and CD8+ T cells, respectively. Treatment with concanavalin A (ConA) at the time of immunization or 2 days later caused suppression and enhancement of the antibody response, respectively. Priming of mice with a sub-immunogenic dose of dextran resulted in profound suppression upon subsequent immunization 3 days later. None of these effects were demonstrable in athymic mice. Transfer of T cells from mice primed 18 h previously with a subimmunogenic dose of dextran suppressed the antibody response in immunized recipients; such suppression was abolished by the treatment of transferred cells with anti Thy 1.2 or anti Lyt2.2 (CD8) antibody in the presence of complement. By contrast, the transfer of T cells from mice, which had been given an immunogenic dose of dextran 4 days previously, increased the antibody response in immunized recipients; such enhancement was abolished by treating transferred cells with anti Thy 1.2 or anti L3T4 (CD4) antibody in the presence of complement. These findings indicate that the immune response to dextran B1355 is regulated by CD4+ T-amplifier cells (Ta cells) and by CD8+ T-suppressor cells (Ts cells) which are activated during the course of a normal antibody response. C1 NIAID,IMMUNOGENET LAB,TWINBROOK 2 RES FACIL,12441 PARKLAWN DR,ROCKVILLE,MD 20852. NR 44 TC 7 Z9 7 U1 0 U2 0 PU GUSTAV FISCHER VERLAG PI STUTTGART PA WOLLGRASWEG 49, D-70599 STUTTGART, GERMANY SN 0171-2985 J9 IMMUNOBIOLOGY JI Immunobiology PD DEC PY 1990 VL 182 IS 1 BP 100 EP 115 PG 16 WC Immunology SC Immunology GA EY893 UT WOS:A1990EY89300010 PM 1711508 ER PT J AU STEINBERG, AD KRIEG, AM GOURLEY, MF KLINMAN, DM AF STEINBERG, AD KRIEG, AM GOURLEY, MF KLINMAN, DM TI THEORETICAL AND EXPERIMENTAL APPROACHES TO GENERALIZED AUTOIMMUNITY SO IMMUNOLOGICAL REVIEWS LA English DT Article ID SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTI-DNA AUTOANTIBODIES; ZEALAND BLACK MICE; RECOMBINANT INBRED LINES; B-CELL ACTIVATION; MRL-LPR/LPR MICE; NZB MICE; MURINE LUPUS; T-CELLS; TOLERANCE INDUCTION C1 US FDA,CBER,RETROVIRUS RES LAB,BETHESDA,MD 20014. RP STEINBERG, AD (reprint author), NIAMS,ARB,CELLULAR IMMUNOL SECT,BLDG 10,ROOM 9N-218,BETHESDA,MD 20892, USA. NR 101 TC 74 Z9 75 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0105-2896 J9 IMMUNOL REV JI Immunol. Rev. PD DEC PY 1990 VL 118 BP 129 EP 163 DI 10.1111/j.1600-065X.1990.tb00815.x PG 35 WC Immunology SC Immunology GA EU700 UT WOS:A1990EU70000006 PM 2079325 ER PT J AU GORDON, JR BURD, PR GALLI, SJ AF GORDON, JR BURD, PR GALLI, SJ TI MAST-CELLS AS A SOURCE OF MULTIFUNCTIONAL CYTOKINES SO IMMUNOLOGY TODAY LA English DT Review ID TUMOR NECROSIS FACTOR; COLONY-STIMULATING FACTOR; NATURAL CYTOTOXIC CELLS; CONNECTIVE-TISSUE-TYPE; DEFICIENT W/WV MICE; CYTO-TOXIC FACTOR; LEUKOCYTE ADHESION; EFFECTOR-CELLS; SOLID TUMORS; IGE AB Mast cells have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, immunologically non-specific inflammatory and fibrotic conditions, angiogenesis, and tissue remodeling and wound healing. However, the molecular basis for the action of the mast cell in many of these responses is obscure. In this review, John Gordon, Parris Burd and Stephen Galli suggest that the production of a broad panel of multifunctional cytokines may represent an important mechanism by which mast cells influence physiological, immunological and pathological processes. C1 BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215. NIAID,BETHESDA,MD 20892. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP GORDON, JR (reprint author), BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215, USA. RI Gordon, John/D-7621-2013 NR 82 TC 668 Z9 676 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0167-5699 J9 IMMUNOL TODAY JI Immunol. Today PD DEC PY 1990 VL 11 IS 12 BP 458 EP 464 DI 10.1016/0167-5699(90)90176-A PG 7 WC Immunology SC Immunology GA EN940 UT WOS:A1990EN94000013 PM 2073318 ER PT J AU MANGUM, JB EVERITT, JI BONNER, JC MOORE, LR BRODY, AR AF MANGUM, JB EVERITT, JI BONNER, JC MOORE, LR BRODY, AR TI COCULTURE OF PRIMARY PULMONARY CELLS TO MODEL ALVEOLAR INJURY AND TRANSLOCATION OF PROTEINS SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY LA English DT Article DE ALVEOLAR TYPE-II CELLS; LUNG FIBROBLASTS; COCULTURE; CELL CULTURE; GROWTH FACTORS ID EPITHELIAL-CELL; II CELLS; HAMSTER LUNGS; GROWTH-FACTOR; MACROPHAGES; FIBROSIS; ASBESTOS; MONOLAYERS; INVITRO; ACID AB Primary rat alveolar type II cells and early passage rat lung fibroblasts were co-cultured on opposite sides of a collagen-coated polycarbonate filter. This is an approach to "model", in part, an alveolar wall to study mechanisms of cytotoxicity and translocation of bioactive materials from the alveolar space to the lung interstitium. Type II cells were the same species, cultured initially in 10% fetal bovine serum and used in the co-culture system at early passage. The type II cells formed a monolayer of dedifferentiated epithelium which provided a barrier on the upper side of the collagen (human type IV)-coated filter. The fibroblasts on the bottom of the filter replicated logarithmically in the presence of serum, could be rendered quiescent in defined medium and then returned to rapid growth phase with the reintroduction of serum. The intact epithelial monolayer excluded trypan blue, albumin, platelet-derived growth factor, and alpha2-macro-globulin from the lower compartment of the culture chamber. Altering the integrity of the monolayer by a variety of means allowed translocation of these materials through the collagen-coated filters. Particularly interesting was the effect of taurine chloramine which caused subtle changes in the alveolar epithelium and allowed subsequent translocation of albumin. In addition, we showed that rat alveolar macrophages remain viable with some spreading on the surface of the epithelial monolayer. This co-culture system will have further application in the study of how reactive oxygen species might affect the epithelial barrier, and whether macrophage-derived growth factors can influence fibroblast proliferation if the monolayer is intact or injured. C1 CHEM IND INST TOXICOL,DEPT EXPTL PATHOL & TOXICOL,RES TRIANGLE PK,NC 27709. NIEHS,PULM PATHOBIOL LAB,RES TRIANGLE PK,NC 27709. NR 33 TC 23 Z9 23 U1 0 U2 0 PU SOC IN VITRO BIOLOGY PI COLUMBIA PA 8815 CENTRE PARK DRIVE SUITE 210, COLUMBIA, MD 21045 SN 0073-5655 J9 IN VITRO CELL DEV B PD DEC PY 1990 VL 26 IS 12 BP 1135 EP 1143 PG 9 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA EZ244 UT WOS:A1990EZ24400008 PM 1706697 ER PT J AU WADOLKOWSKI, EA SUNG, LM BURRIS, JA SAMUEL, JE OBRIEN, AD AF WADOLKOWSKI, EA SUNG, LM BURRIS, JA SAMUEL, JE OBRIEN, AD TI ACUTE RENAL TUBULAR-NECROSIS AND DEATH OF MICE ORALLY INFECTED WITH ESCHERICHIA-COLI STRAINS THAT PRODUCE SHIGA-LIKE TOXIN TYPE-II SO INFECTION AND IMMUNITY LA English DT Article C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MICROBIOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814. NIH,NATL CTR RES RESOURCES,BETHESDA,MD 20892. FU NIAID NIH HHS [AI 20148-07] NR 50 TC 155 Z9 157 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 1990 VL 58 IS 12 BP 3959 EP 3965 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EK781 UT WOS:A1990EK78100022 PM 2254023 ER PT J AU STGEME, JW FALKOW, S AF STGEME, JW FALKOW, S TI HAEMOPHILUS-INFLUENZAE ADHERES TO AND ENTERS CULTURED HUMAN EPITHELIAL-CELLS SO INFECTION AND IMMUNITY LA English DT Article C1 NIAID,ROCKY MT LABS,HAMILTON,MT 59840. RP STGEME, JW (reprint author), STANFORD UNIV,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305, USA. FU NIAID NIH HHS [AI 26195]; PHS HHS [00850] NR 27 TC 151 Z9 153 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 1990 VL 58 IS 12 BP 4036 EP 4044 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EK781 UT WOS:A1990EK78100033 PM 2254028 ER PT J AU HENDERSON, DK AF HENDERSON, DK TI POSITION PAPER - THE HIV-INFECTED HEALTH-CARE WORKER SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; HEPATITIS-B; TRANSMISSION; PHYSICIANS RP HENDERSON, DK (reprint author), NIH,HOSP EPIDEMIOL SERV CLIN CTR,9000 ROCKVILLE PIKE,BLDG 10,11 233,BETHESDA,MD 20892, USA. NR 33 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD DEC PY 1990 VL 11 IS 12 BP 647 EP 656 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA FE267 UT WOS:A1990FE26700007 ER PT J AU GOEDEGEBUURE, PS BRAAKMAN, E SEGAL, DM VREUGDENHIL, RJ BOLHUIS, RLH AF GOEDEGEBUURE, PS BRAAKMAN, E SEGAL, DM VREUGDENHIL, RJ BOLHUIS, RLH TI LYMPHOCYTE LEUKOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 INTERACTING WITH TARGET-CELL INTERCELLULAR-ADHESION MOLECULE-1 CO-ACTIVATES CYTOLYSIS TRIGGERED VIA CD16 OR THE RECEPTOR INVOLVED IN MAJOR HISTOCOMPATIBILITY ANTIGEN-UNRESTRICTED LYSIS SO INTERNATIONAL IMMUNOLOGY LA English DT Article DE LFA-1; ICAM-1; MHC-UNRESTRICTED LYSIS ID NATURAL-KILLER CELLS; MONOCLONAL-ANTIBODY; T-CELLS; LFA-1-DEPENDENT ADHESION; CYTO-TOXICITY; TUMOR-CELLS; ALPHA-CHAIN; LFA-1; ICAM-1; LIGAND AB The binding of leukocyte function-associated antigen 1 (LFA-1) (CD11a/CD18) to its natural target ligand, intercellular adhesion molecule 1 (ICAM-1) (CD54), is an important step in lymphocyte adhesion to cells and its subsequent activation. We studied whether LFA-1 - ICAM-1 interactions affect tumor cell suceptibility to MHC-unrestricted lysis by TCR-CD3-CD16+ natural killer (NK) and TCR-gamma-delta-+CD3+CD16+/- lymphocytes. Moreover, tumor target cell susceptibility to anti-CD16 mAb-triggered lysis by TCR- NK cells was investigated. Therefore, ICAM-1+ or ICAM-1- tumor cell lines were used as target cells. Two melanoma-derived cell lines expressing little or no ICAM-1 were relatively resistant to MHC-unrestricted lysis as well as anti-CD16 mAb-triggered lysis by fresh or cloned TCR- NK cells. The ICAM-1- melanoma cell line was also relatively resistant to MHC-unrestricted lysis by TCR-gamma-delta-+ clones. Tumor necrosis factor (TNF) induced ICAM-1 expression on ICAM-1- tumor cells, and simulataneously increased target cell susceptibility to MHC-unrestricted as well as to anti-CD16 mAb-triggered lysis. This enhanced level of lysis was inhibited by anti-ICAM-1 mAb. Our data demonstrate that LFA-1 - ICAM-1 interactions increase MHC-unrestricted or CD16-mediated cytolysis of tumor cells. Anti-CD18 (LFA-1-beta) mAb inhibited MHC-unrestricted lysis of ICAM-1+ and ICAM-1- tumor cells. However, anti-CD18 mAb only blocked formation of lymphocyte - target cell conjugates with ICAM-1+ but not with ICAM-1- target cells. These results suggest that LFA-1 can mediate positive as well as negative signals. Our data also show that LFA-1 - ICAM-1 interactions co-activate and regulate cytotoxicity triggered via the receptor structure(s) involved in MHC-unrestricted lysis as well as via CD16. C1 DR DANIEL DENHOED CANC CTR,DEPT IMMUNOL,POB 5201,3008 AE ROTTERDAM,NETHERLANDS. TNO,HLTH ORG,INST APPL RADIOBIOL & IMMUNOL,2280 HV RIJSWIJK,NETHERLANDS. NCI,EXPTL IMMUNOL BRANCH,BALTIMORE,MD 21211. NR 46 TC 19 Z9 19 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0953-8178 J9 INT IMMUNOL JI Int. Immunol. PD DEC PY 1990 VL 2 IS 12 BP 1213 EP 1220 DI 10.1093/intimm/2.12.1213 PG 8 WC Immunology SC Immunology GA ET499 UT WOS:A1990ET49900011 PM 1982501 ER PT J AU HAYES, RB BROWN, LM POTTERN, LM GOMEZ, M KARDAUN, JWPF HOOVER, RN OCONNELL, KJ SUTZMAN, RE JAVADPOUR, N AF HAYES, RB BROWN, LM POTTERN, LM GOMEZ, M KARDAUN, JWPF HOOVER, RN OCONNELL, KJ SUTZMAN, RE JAVADPOUR, N TI OCCUPATION AND RISK FOR TESTICULAR CANCER - A CASE-CONTROL STUDY SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Article ID NATURAL-GAS EXTRACTION; UNITED-STATES; YOUNG MEN; TESTIS; EPIDEMIOLOGY; TUMORS; AGRICULTURE; EMPLOYMENT; EXPOSURE; DENMARK AB A case-control study of 271 testicular cancer cases aged 18-42, including 60 seminomas and 206 other germinal cell tumours, and 259 controls was carried out to study the association between occupation and testicular cancer risk. Study subjects were identified at three medical centres, two of which treat military personnel. Controls were men diagnosed with a cancer other than of the genital tract. Associations were identified between professional employment (administrators, teachers and other professionals) and risk for testicular seminoma, OR = 2.8 (95% Cl: 1.4-5.4) and between employment in production work and risk for other germinal cell tumours, OR = 1.8 (95% Cl: 1.1-2.7). No specific occupations within these broad groups were responsible for the observed increases. Self-reported exposure to microwaves and other radio waves was associated with an excess risk for both seminomas and other germinal cell tumours. However, an assessment of radio wave exposure based on job title did not support this finding. Although testicular cancer has been increasing in recent decades among young males, occupational factors did not appear to account for a substantial proportion of testicular cancer occurrence in the population studied. C1 NCI,DIV CANC TREATMENT,BETHESDA,MD 20892. USN HOSP,UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UNIFORMED SERV UNIV HLTH SCI,WASHINGTON,DC 20307. RP HAYES, RB (reprint author), NCI,ENVIRONM EPIDEMIOL BRANCH,EPIDEMIOL & BIOSTAT PROGRAM,EPN 418,BETHESDA,MD 20892, USA. NR 36 TC 44 Z9 44 U1 1 U2 2 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD DEC PY 1990 VL 19 IS 4 BP 825 EP 831 DI 10.1093/ije/19.4.825 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA ET595 UT WOS:A1990ET59500008 PM 1964675 ER PT J AU FRIEDMAN, GD TEKAWA, I GRIMM, RH MANOLIO, T SHANNON, SG SIDNEY, S AF FRIEDMAN, GD TEKAWA, I GRIMM, RH MANOLIO, T SHANNON, SG SIDNEY, S TI THE LEUKOCYTE COUNT - CORRELATES AND RELATIONSHIP TO CORONARY RISK-FACTORS - THE CARDIA STUDY SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Article ID LEUKOCYTE COUNT; MYOCARDIAL-INFARCTION; CIGARETTE-SMOKING; JAPANESE COHORT; HEART-DISEASE; CELL COUNT AB Correlates of the leucocyte count (WBC) and its relationships to other coronary heart disease (CHD) risk factors were assessed in 4981 black and white young adults. Mean WBC was higher in women than men, higher in whites than blacks, and higher in those aged 18-24 than aged 25-30 years. It also varied by season with the highest levels in the autumn. Other characteristics with persistent statistically significant direct associations with the WBC after multivariate adjustments were cigarette smoking, marijuana use, geographical location (possibly an inter-laboratory artifact), use of birth control pills, body mass index, pulse rate, and systolic blood pressure; height, physical fitness and high density lipoprotein cholesterol (HDL-C) level were inversely associated with the WBC. The negative association of WBC with HDL-C was too small to explain the association of WBC with CHD found elsewhere. The WBC is a commonly performed clinical test; yet much remains to be learned about its variation in the general population and its value as a predictor rather than merely an indicator of disease. C1 KAISER PERMANENTE MED CARE PROGRAM,DIV RES,NO CALIF REG,OAKLAND,CA. UNIV ALABAMA,SCH PUBL HLTH,DEPT EPIDEMIOL,BIRMINGHAM,AL. UNIV MINNESOTA,SCH PUBL HLTH,DIV EPIDEMIOL,MINNEAPOLIS,MN 55455. NHLBI,EBP,DECA,CLIN & GENET EPIDEMIOL BRANCH,BETHESDA,MD 20892. FU NHLBI NIH HHS [N01-HC-48047, N01-HC-48049, N01-HC-48048] NR 19 TC 89 Z9 90 U1 2 U2 3 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD DEC PY 1990 VL 19 IS 4 BP 889 EP 893 DI 10.1093/ije/19.4.889 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA ET595 UT WOS:A1990ET59500017 PM 2084017 ER PT J AU CUSHMAN, M CHINNASAMY, P CHAKRABORTI, AK JURAYJ, J GEAHLEN, RL HAUGWITZ, RD AF CUSHMAN, M CHINNASAMY, P CHAKRABORTI, AK JURAYJ, J GEAHLEN, RL HAUGWITZ, RD TI SYNTHESIS OF [BETA-(4-PYRIDYL-1-OXIDE)-L-ALANINE4]-ANGIOTENSIN I AS A POTENTIAL SUICIDE SUBSTRATE FOR PROTEIN-TYROSINE KINASES SO INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH LA English DT Article DE ANGIOTENSIN-I; ASYMMETRIC SYNTHESIS; PROTEIN-TYROSINE KINASE, BETA-(4-PYRIDYL-1-OXIDE)-ALANINE; SUICIDE SUBSTRATE (MECHANISM-BASED) ENZYME INHIBITORS ID ROUS-SARCOMA VIRUS; ASYMMETRIC SYNTHESES; ENANTIOSELECTIVE SYNTHESIS; TRANSFORMED CELLS; GENE-PRODUCT; AMINO-ACIDS; L-VALINE; INHIBITION; RECEPTOR; GROWTH AB An asymmetric synthesis of [beta-(4-pyridyl-l-oxide)-L-alanine4]?? -angiotensin I (1a), which is a potential suicide substrate (mechanism-based inhibitor) for protein-tyrosine kinases, has been performed. Deprotonation of 6 with n-butyllithium in THF gave the anion 7, which was alkylated with 4-(chloromethyl)pyridine-1-oxide to afford intermediate 9 as a crystalline solid. Hydrolysis of 9 afforded a mixture of 11 and 12 in a ratio of 96:4 as estimated by conversion to the diastereomeric dipeptides 13 and 14 followed by HPLC analysis. The 96:4 mixture of 11 and 12 was used in the solid phase synthesis of the target angiotensin analog 1a and its diastereomer 1b, which were separated and tested for inhibitory activity against two thymocyte protein-tyrosine kinases: p40 and p56lck. Neither peptide displayed significant inhibitory activity toward p40 and both served as weak competitive inhibitors of p56lck. C1 NCI,BETHESDA,MD 20892. RP CUSHMAN, M (reprint author), PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907, USA. FU NCI NIH HHS [CA-47476, N01-CM-67699] NR 43 TC 11 Z9 11 U1 0 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0367-8377 J9 INT J PEPT PROT RES JI Int. J. Pept. Protein Res. PD DEC PY 1990 VL 36 IS 6 BP 538 EP 543 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EQ055 UT WOS:A1990EQ05500008 PM 2090646 ER PT J AU DSOUZA, RN HAPPONEN, RP FLANDERS, KC BUTLER, WT AF DSOUZA, RN HAPPONEN, RP FLANDERS, KC BUTLER, WT TI HISTOCHEMICAL-LOCALIZATION OF TRANSFORMING GROWTH FACTOR-BETA-1 IN DEVELOPING RAT MOLARS USING ANTIBODIES TO DIFFERENT EPITOPES SO JOURNAL DE BIOLOGIE BUCCALE LA English DT Article; Proceedings Paper CT 4TH WORKSHOP ON TOOTH MORPHOGENESIS AND DEVELOPMENT CY MAY 30-JUN 02, 1990 CL ARC & SENANS, FRANCE SP CNRS, FDN DENT FRANCE, INSERM, MINIST EDUC NATL JEUNESSE & SPORTS FRANCE, MINIST RECH & TECHNOL FRANCE DE GROWTH FACTORS; TGF-BETA-1; ODONTOGENESIS; IMMUNOHISTOCHEMISTRY; DENTAL ORGAN ID FACTOR-TYPE-BETA; EXTRACELLULAR-MATRIX; EXPRESSION; CELLS; FACTOR-BETA-1; INDUCTION; PATTERN; TISSUES; INVITRO; TOOTH AB In this study transforming growth factor -beta-1 (TGF-beta-1) has been immunolocalized in developing rat molars using two well characterized polyclonal antibodies, Anti-CC and Anti-LC, that recognize extracellular and intracellular TGF-beta-1, respectively. With immunohistochemical methods and the ABC-peroxidase system of detection, the growth factor was immunolocalized within the ectodermally derived enamel organ and the neural crest-derived dental papilla at the early and advanced bell stages of development. With Anti-CC, widespread and abundant extracellular TGF-beta-1 was found associated with the stellate reticulum and within central and apical regions of dental papilla mesenchyme. In contrast, Anti-LC localized TGF-beta-1 intensely within the cells of the outer dental epithelium. Moderate immunostaining for TGF-beta-1 with Anti-LC was also evident within the apical cytoplasm of inner dental epithelial cells and odontoblasts. These findings support the hypothesis that TGF-beta-1 may play a paracrine role in tooth development by regulating the epithelial-mesenchymal interactions that influence growth and cytodifferentiation events. C1 UNIV TEXAS, HLTH SCI CTR, DENT BRANCH, DEPT BIOL CHEM, HOUSTON, TX 77225 USA. UNIV TURKU, INST DENT, SF-20500 TURKU 50, FINLAND. NCI, CHEMOPREVENT, BETHESDA, MD 20892 USA. RP DSOUZA, RN (reprint author), UNIV TEXAS, HLTH SCI CTR, DENT BRANCH, DEPT ANAT SCI, HOUSTON, TX 77225 USA. OI D'Souza, Rena/0000-0002-1505-5173 FU NIDCR NIH HHS [DE 05092, DE 08955] NR 30 TC 11 Z9 12 U1 0 U2 0 PU SOC NOUVELLE PUBL MEDICALES DENTAIRES PI PARIS 09 PA 42 RUE VIGNON, 75442 PARIS 09, FRANCE SN 0301-3952 J9 J BIOL BUCCALE PD DEC PY 1990 VL 18 IS 4 BP 299 EP 306 PG 8 WC Biology; Dentistry, Oral Surgery & Medicine SC Life Sciences & Biomedicine - Other Topics; Dentistry, Oral Surgery & Medicine GA EX882 UT WOS:A1990EX88200006 PM 1710211 ER PT J AU BRAINARD, GC SHERRY, D SKWERER, RG WAXLER, M KELLY, K ROSENTHAL, NE AF BRAINARD, GC SHERRY, D SKWERER, RG WAXLER, M KELLY, K ROSENTHAL, NE TI EFFECTS OF DIFFERENT WAVELENGTHS IN SEASONAL AFFECTIVE-DISORDER SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE DEPRESSION; SEASONS; LIGHT; WAVELENGTH; SEASONAL AFFECTIVE DISORDER ID SYRIAN-HAMSTER; PINEAL MELATONIN; LIGHT IRRADIANCE; PHOTOTHERAPY; SUPPRESSION; SPECTRA; ANTIDEPRESSANT; HYPOTHESIS; THERAPY; SYSTEM AB The aim of this study was to compare the relative therapeutic efficacies of three different light sources for treating winter depression. A balanced incomplete block crossover design was employed, whereby all patients (n = 18) were randomly assigned to two out of the three treatment conditions: white, red and blue light. The degree of depression was assessed by the 21-item Hamilton Depression Rating Scale. The date suggest that at a photon density of 2.3 X 10(15) phonton/s/cm2, white light has greater therapeutic benefit than red or blue light. It is clear that a larger sample population should be tested to confirm this result. This preliminary finding indicated that light sources currently in use for phototherapy could not be improved by narrowing the wavelengths and shifting them towards either end of the visible spectrum. C1 NIMH,CLIN PSYCHOBIOL BRANCH,BETHESDA,MD 20892. RP BRAINARD, GC (reprint author), THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT NEUROL,1025 WALNUT ST,PHILADELPHIA,PA 19107, USA. NR 34 TC 42 Z9 42 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD DEC PY 1990 VL 20 IS 4 BP 209 EP 216 DI 10.1016/0165-0327(90)90052-A PG 8 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EN640 UT WOS:A1990EN64000001 PM 2149726 ER PT J AU MASER, JD SOLOMON, SD AF MASER, JD SOLOMON, SD TI PSYCHOSOCIAL AND PSYCHOBIOLOGICAL CONSEQUENCES OF EXPOSURE TO EXTREME STRESSORS SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article C1 NIMH,DIV CLIN RES,ROOM 10C05,5600 FISHERS LANE,ROCKVILLE,MD 20857. NR 16 TC 4 Z9 4 U1 0 U2 0 PU V H WINSTON & SON INC PI PALM BEACH PA 360 SOUTH OCEAN BLVD, PH-B, PALM BEACH, FL 33480 SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD DEC PY 1990 VL 20 IS 21 BP 1725 EP 1732 DI 10.1111/j.1559-1816.1990.tb01507.x PN 1 PG 8 WC Psychology, Social SC Psychology GA EP240 UT WOS:A1990EP24000001 ER PT J AU BEEBE, L PARK, SS ANDERSON, LM AF BEEBE, L PARK, SS ANDERSON, LM TI DIFFERENTIAL ENZYME-INDUCTION OF MOUSE-LIVER AND LUNG FOLLOWING A SINGLE LOW OR HIGH-DOSE OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE CYTOCHROME-P-450; TCDD; LIVER; LUNG ID ARYL-HYDROCARBON HYDROXYLASE; INDUCER-RECEPTOR COMPLEX; AH-RECEPTOR; POLYBROMINATED BIPHENYLS; TISSUE DISTRIBUTION; BIOLOGICAL-ACTIVITY; TUMOR PROMOTION; ALTERED FOCI; RATS; MICE AB The induction response of cytochrome P-450-dependent enzyme activities to a single low (5 nmol/kg) or high (50 nmol/kg, intraperitoneal [ip] dose of TCDD was examined in liver and lung homogenates over a 12-week time course in an outbred, Ah-responsive strain of mice (National Institutes of Health [NIH] Swiss). Total hepatic cytochrome P-450 was quantified, and the dealkylation of ethoxy- and benzyloxyresorufin (activities of P-450 IA1 and IIB1, respectively) were measured in both tissues at 48 and 96 hr and at 1, 4, and 12 weeks post-TCDD administration. Western immunoblotting with monoclonal antibody 1-7-1 was conducted to confirm the specific IA1-inductive effects of each dose of TCDD over the same time course. Following the low dose, specific IA1 induction was apparent in liver at the earliest time point, was maximal at 1 week, and declined to control values at 12 weeks. Pulmonary IA1 was near-maximally induced at 48 hr, and remained at that level for 4 weeks. In contrast, a tenfold higher dose of TCDD elicited similar IA1 induction profiles for both tissues, with a maximum at 1 week and a progressive loss at 4 and 12 weeks postexposure. P-450 IIB1 activity was elevated in TCDD-treated animals by enzymatic assay; however, Western immunoblotting did not confirm this finding. These data demonstrate persistent dose-dependent P450 induction over many weeks by a single TCDD dose, with significant organ-specific differences: (a) lung is more sensitive than liver to a nonmaximal inducing dose of TCDD, and (b) at a maximally inducing dose of TCDD, lung is very similar to liver in both the level and time course of IA1 induction. RP BEEBE, L (reprint author), NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702, USA. NR 46 TC 37 Z9 37 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD WIN PY 1990 VL 5 IS 4 BP 211 EP 219 DI 10.1002/jbt.2570050403 PG 9 WC Toxicology SC Toxicology GA EW304 UT WOS:A1990EW30400002 PM 2096217 ER PT J AU SZNOL, M MIER, JW SPARANO, J GAYNOR, ER WEISS, GR MARGOLIN, KA BAR, MH HAWKINS, MJ ATKINS, MB DUTCHER, JP FISHER, RI BOLDT, DH DOROSHOW, JH LOUIE, A ARONSON, FR AF SZNOL, M MIER, JW SPARANO, J GAYNOR, ER WEISS, GR MARGOLIN, KA BAR, MH HAWKINS, MJ ATKINS, MB DUTCHER, JP FISHER, RI BOLDT, DH DOROSHOW, JH LOUIE, A ARONSON, FR TI A PHASE-I STUDY OF HIGH-DOSE INTERLEUKIN-2 IN COMBINATION WITH INTERFERON-ALPHA-2B SO JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS LA English DT Article DE INTERLEUKIN-2; INTERFERON-ALPHA-2B; ADVANCED MALIGNANCIES; PHASE-I TRIAL ID ACTIVATED KILLER CELLS; ALPHA-INTERFERON; RECOMBINANT INTERLEUKIN-2; MALIGNANT-MELANOMA; CLINICAL-TRIAL; CANCER; IMMUNOTHERAPY; THERAPY; INVIVO; METASTASES AB Our group and others have conducted phase II trials of high-dose interleukin-2 (IL-2) or IL-2 with the adoptive transfer of in vitro activated lymphocytes in patients with advanced malignancies. Although durable complete and partial responses were seen in patients with renal cell carcinoma and metastatic melanoma, overall response rates were low and toxicity was substantial. In preclinical models, the combination of IL-2 and interferon-alpha has synergistic antitumor activity. Based on these data, and our prior experience with high-dose IL-2 (Cetus), we conducted a trial to determine the maximum tolerated dose of IL-2 (0.4, 0.8, and 1.2 mg/m2) administered together with a fixed dose of interferon-alpha-2b (3 x 10(6) u/m2) intravenously every 8 h on days 1-5 and 15-19. Patients were monitored in the intensive care unit and given pressor support for hypotension as needed. Twenty-four patients were entered (6, 10, and 8 at each IL-2 dose, respectively; 14 renal cell carcinoma, 7 melanoma, 2 colon, and 1 hepatoma). The median age was 56 years, the male to female ratio was 19:5, and performance status was 0 or 1 (Eastern Cooperative Oncology Group) in all patients. Toxicity was similar at all dose levels, but the onset was earlier in the treatment course as the dose of IL-2 was escalated in successive cohorts; therefore, more doses were withheld at the higher dose levels. The major toxicities resulting in the interruption or stopping of treatment were hypotension requiring pressors, dyspnea, and neurotoxicity. Grade 1 or 2 fever, nausea and vomiting, fatigue, and cutaneous reactions were common at all dose levels. Reversible grade 3 or 4 transaminase elevations were also seen in most patients, but were not considered dose limiting. Three objective responses were noted in patients with renal cell carcinoma: one at dose level 2 and two at dose level 3. Dose level 2 was chosen for further phase II evaluation. C1 ALBERT EINSTEIN CANC CTR,NEW YORK,NY. NEW ENGLAND MED CTR HOSP,BOSTON,MA 02111. LOYOLA UNIV,MED CTR,MAYWOOD,IL 60153. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. CITY HOPE NATL MED CTR,DUARTE,CA 91010. UNIV CALIF SAN FRANCISCO,MED CTR,SAN FRANCISCO,CA 94143. CETUS CORP,EMERYVILLE,CA 94608. RP SZNOL, M (reprint author), NCI,INVEST DRUG BRANCH,CANC THERAPY EVALUAT PROGRAM,BETHESDA,MD 20892, USA. FU NCI NIH HHS [N01-CM73704, N01-CM73702, N01-CM73703] NR 37 TC 29 Z9 29 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0732-6580 J9 J BIOL RESP MODIF PD DEC PY 1990 VL 9 IS 6 BP 529 EP 537 PG 9 WC Biology; Oncology; Immunology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Oncology; Immunology; Research & Experimental Medicine GA EP732 UT WOS:A1990EP73200001 PM 2074439 ER PT J AU SUMNER, SCJ GALLAGHER, KS DAVIS, DG COVELL, DG JERNIGAN, RL FERRETTI, JA AF SUMNER, SCJ GALLAGHER, KS DAVIS, DG COVELL, DG JERNIGAN, RL FERRETTI, JA TI CONFORMATIONAL-ANALYSIS OF THE TACHYKININS IN SOLUTION - SUBSTANCE-P AND PHYSALAEMIN SO JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS LA English DT Article ID BINDING-SITES; MAGNETIC-RESONANCE; NOE SPECTROSCOPY; ROTATING-FRAME; RECEPTORS; FRAGMENTS; ANALOGS; PEPTIDE; BRAIN AB A determination of the solution conformational behavior of two tachykinins, substance P and physalaemin, is described. Two-dimensional homonuclear Hartmann-Hahn (HOHAHA) and rotating-frame cross relaxation spectroscopy (ROESY) are used to obtain complete proton resonance assignments. Interproton distance restraints obtained from ROESY spectroscopy are used to characterize the conformational behavior. These data show that in solution both substance P and physalaemin exist in a mixture of conformational states, rather than as a single three-dimensional structure. In water both peptides prefer to be in an extended chain structure. In methanol, their behavior is described as a mixture of beta-turn conformations in dynamic equilibrium. Solvent titration data and chemical shift temperature coefficients complement the NMR estimate of interproton distances by locating hydrogen bonds and serving to identify predominant conformational states. The C-terminal tetrapeptide segment has the same conformational behavior for both substance P and physalaemin. In physalaemin, the midsegment of the peptide may also be constrained by formation of a salt bridge. The conformational behavior of substance P and physalaemin is discussed in relation to potency and receptor binding properties. C1 NHLBI,BIOPHYS CHEM LAB,BETHESDA,MD 20892. NCI,MATH BIOL LAB,BETHESDA,MD 20892. RI Jernigan, Robert/A-5421-2012 FU PHS HHS [N01-C0-74102] NR 33 TC 47 Z9 47 U1 0 U2 2 PU ADENINE PRESS INC PI GUILDERLAND PA PO BOX 355/340, GUILDERLAND, NY 12084 SN 0739-1102 J9 J BIOMOL STRUCT DYN JI J. Biomol. Struct. Dyn. PD DEC PY 1990 VL 8 IS 3 BP 687 EP 707 PG 21 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EU236 UT WOS:A1990EU23600014 PM 1713036 ER PT J AU DONALDSON, JG LIPPINCOTTSCHWARTZ, J BLOOM, GS KREIS, TE KLAUSNER, RD AF DONALDSON, JG LIPPINCOTTSCHWARTZ, J BLOOM, GS KREIS, TE KLAUSNER, RD TI DISSOCIATION OF A 110-KD PERIPHERAL MEMBRANE-PROTEIN FROM THE GOLGI-APPARATUS IS AN EARLY EVENT IN BREFELDIN-A ACTION SO JOURNAL OF CELL BIOLOGY LA English DT Article ID ENDOPLASMIC-RETICULUM; SECRETORY PROTEINS; HELA-CELLS; MICROTUBULES; COMPLEX; ORGANIZATION; TRANSPORT; ELEMENTS; STACK AB Brefeldin A (BFA) has a profound effect on the structure of the Golgi apparatus, causing Golgi proteins to redistribute into the ER minutes after drug treatment. Here we describe the dissociation of a 110-kD cytoplasmically oriented peripheral membrane protein (Allan, V. J., and T. E. Kreis. 1986. J. Cell Biol. 103:2229-2239) from the Golgi apparatus as an early event in BFA action, preceding other morphologic changes. In contrast, other peripheral membrane proteins of the Golgi apparatus were not released but followed Golgi membrane into the ER during BFA treatment. The 110-kD protein remained widely dispersed throughout the cytoplasm during drug treatment, but upon removal of BFA it reassociated with membranes during reformation of the Golgi apparatus. Although a 30-s exposure to the drug was sufficient to cause the redistribution of the 110-kD protein, removal of the drug after this short exposure resulted in the reassociation of the 110-kD protein and no change in Golgi structure. If cells were exposed to BFA for 1 min or more, however, a portion of the Golgi membrane was committed to move into and out of the ER after removal of the drug. ATP depletion also caused the reversible release of the 110-kD protein, but without Golgi membrane redistribution into the ER. These findings suggest that the interaction between the 110-kD protein and the Golgi apparatus is dynamic and can be perturbed by metabolic changes or the drug BFA. C1 UNIV TEXAS,SW MED CTR,DEPT CELL BIOL & NEUROSCI,DALLAS,TX 75235. EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY. RP DONALDSON, JG (reprint author), NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892, USA. NR 26 TC 377 Z9 379 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9525 J9 J CELL BIOL JI J. Cell Biol. PD DEC PY 1990 VL 111 IS 6 BP 2295 EP 2306 DI 10.1083/jcb.111.6.2295 PN 1 PG 12 WC Cell Biology SC Cell Biology GA ET176 UT WOS:A1990ET17600008 PM 2277061 ER PT J AU BARSONY, J PIKE, JW DELUCA, HF MARX, SJ AF BARSONY, J PIKE, JW DELUCA, HF MARX, SJ TI IMMUNOCYTOLOGY WITH MICROWAVE-FIXED FIBROBLASTS SHOWS 1-ALPHA,25-DIHYDROXYVITAMIN-D3-DEPENDENT RAPID AND ESTROGEN-DEPENDENT SLOW REORGANIZATION OF VITAMIN-D RECEPTORS SO JOURNAL OF CELL BIOLOGY LA English DT Article ID CULTURED SKIN FIBROBLASTS; STEROID-HORMONE RECEPTORS; GLUCOCORTICOID-RECEPTOR; MONOCLONAL-ANTIBODIES; 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR; IMMUNOCYTOCHEMICAL LOCALIZATION; INTRACELLULAR-LOCALIZATION; PROGESTERONE-RECEPTOR; NUCLEAR-LOCALIZATION; INTESTINAL RECEPTOR AB Prior studies have given no evidence for regulation of vitamin D receptor (VDR) compartmentalization or subcellular organization. Microwave fixation (9-15 s) and an indirect immunodetection system of avidin-biotin enhancement and phycoerythrin fluorophore resulted in sufficient spatial and temporal resolution to allow analysis of these processes. We studied cultured fibroblasts from normals or from patients with four different types of hereditary defect compromising VDR function (mutant cells). Compartmentalization of VDRs in the absence of 1,25-dihydroxyvitamin D3 (calcitriol) was regulated by serum or estrogen. VDRs were mainly cytoplasmic in cells cultured without serum and phenol red, but VDRs were mainly intranuclear after addition of serum or an estrogen to cells for at least 18 h (slow regulation). Calcitriol initiated a rapid and multistep process (rapid regulation) of reorganization in a portion of VDRs: clumping within 15-45 s, alignment of clumps along fibrils within 30-45 s, perinuclear accumulation of clumps within 45-90 s, and intranuclear accumulation of clumps within 1-3 min. We found similar rapid effects of calcitriol on VDRs in various other types of cultured cells. These sequential VDR pattern changes showed calcitriol dose dependency and calcitriol analogue specificity characteristic for the VDR. In mutant fibroblasts VDR pattern changes after calcitriol were absent or severely disturbed at selected steps. Treatment of normal cells with wheat germ agglutinin, which blocks protein transport through nuclear pores, also blocked calcitriol-dependent translocation of VDRs. We conclude that immunocytology after microwave fixation provides evidence for regulation of VDR organization and localization. C1 BAYLOR UNIV,DEPT PEDIAT,HOUSTON,TX 77030. BAYLOR UNIV,DEPT CELL BIOL,HOUSTON,TX 77030. UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706. RP BARSONY, J (reprint author), NIDDKD,MINERAL METAB SECT,BETHESDA,MD 20892, USA. NR 77 TC 88 Z9 89 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9525 J9 J CELL BIOL JI J. Cell Biol. PD DEC PY 1990 VL 111 IS 6 BP 2385 EP 2395 DI 10.1083/jcb.111.6.2385 PN 1 PG 11 WC Cell Biology SC Cell Biology GA ET176 UT WOS:A1990ET17600016 PM 2177476 ER PT J AU DANIELS, MP AF DANIELS, MP TI LOCALIZATION OF ACTIN, BETA-SPECTRIN, 43X10(3)MR AND 58X10(3)MR PROTEINS TO RECEPTOR-ENRICHED DOMAINS OF NEWLY FORMED ACETYLCHOLINE-RECEPTOR AGGREGATES IN ISOLATED MYOTUBE MEMBRANES SO JOURNAL OF CELL SCIENCE LA English DT Article DE MEMBRANE CYTOSKELETON; NEUROMUSCULAR JUNCTION; ACETYLCHOLINE RECEPTORS; MUSCLE CULTURE ID TORPEDO ELECTRIC ORGAN; CULTURED RAT MYOTUBES; SKELETAL-MUSCLE CELLS; NEUROMUSCULAR-JUNCTION; MONOCLONAL-ANTIBODIES; CHICK MYOTUBES; BRAIN EXTRACT; CLUSTERS; CYTOSKELETON; CLATHRIN AB I have examined the possible involvement of specific cytoskeletal and peripheral membrane proteins in the early stages of acetylcholine receptor (AChR) aggregation in rat myotubes in culture by immunofluorescence localization of these proteins on the cytoplasmic face of isolated plasma membranes. A culture procedure utilizing selective replating of myoblasts and subsequent treatment with cytosine arabinoside was devised to obtain large, multipolar myotubes with extensive upper surfaces that are free of fibroblasts. These cultures were exposed for 4-6 h to embryonic pig brain extract (EBX) to induce AChR aggregate formation on the upper cell surface, and the AChRs were labeled with TRITC-conjugated alpha-bungarotoxin. Large sheets of plasma membranes from the upper cell surface were isolated by adhesion to a coverslip coated with a polypeptide adhesive (Cell-Tak) that was pressed on top of the culture. The membranes were labeled by indirect immunofluorescence with monoclonal antibodies against the 43 X 10(3) M(r) and 58 X 10(3) M(r) proteins, originally identified in the AChR-enriched membranes of Torpedo electroplaques, and with monoclonal antibodies against isoforms of actin and beta-spectrin. The labeling patterns showed that all four of these proteins are concentrated in the punctate AChR-enriched domains within the aggregates, suggesting that they may be involved in the early stages of AChR aggregation. Immunofluorescence labeling with monoclonal antibodies against vinculin and clathrin, and with an antiserum to talin, showed that these proteins are also associated with AChR aggregates; however, their labeling patterns did not correspond closely to the AChR-enriched domains. Furthermore, vinculin and talin dissociated from most of the membrane during isolation. The concentration of beta-spectrin and actin isoforms on the cytoplasmic face of the AChR-enriched domains is consistent with the formation, early in the aggregation process, of a membrane-cytoskeleton association similar to that of erythrocytes. RP DANIELS, MP (reprint author), NHLBI,BIOCHEM GENET LAB,BLDG 36,ROOM 1C06,BETHESDA,MD 20892, USA. NR 57 TC 45 Z9 47 U1 0 U2 0 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS, ENGLAND CB4 4DL SN 0021-9533 J9 J CELL SCI JI J. Cell Sci. PD DEC PY 1990 VL 97 BP 615 EP 627 PN 4 PG 13 WC Cell Biology SC Cell Biology GA EQ316 UT WOS:A1990EQ31600005 PM 2127596 ER PT J AU BUTTERS, N GRANT, I HAXBY, J JUDD, LL MARTIN, A MCCLELLAND, J PEQUEGNAT, W SCHACTER, D STOVER, E AF BUTTERS, N GRANT, I HAXBY, J JUDD, LL MARTIN, A MCCLELLAND, J PEQUEGNAT, W SCHACTER, D STOVER, E TI ASSESSMENT OF AIDS-RELATED COGNITIVE CHANGES - RECOMMENDATIONS OF THE NIMH WORKSHOP ON NEUROPSYCHOLOGICAL ASSESSMENT APPROACHES SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY LA English DT Article C1 NIMH,OFF AIDS PROGRAMS,PARKLAWN BLDG,ROOM 17-C06,5600 FISHERS LANE,ROCKVILLE,MD 20857. RI martin, alex/B-6176-2009; OI Schacter, Daniel/0000-0002-2460-6061 NR 33 TC 143 Z9 148 U1 0 U2 0 PU SWETS ZEITLINGER PUBLISHERS PI LISSE PA P O BOX 825, 2160 SZ LISSE, NETHERLANDS SN 1380-3395 J9 J CLIN EXP NEUROPSYC JI J. Clin. Exp. Neuropsychol. PD DEC PY 1990 VL 12 IS 6 BP 963 EP 978 DI 10.1080/01688639008401035 PG 16 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA EL788 UT WOS:A1990EL78800012 PM 2286659 ER PT J AU LAUE, L LOTZE, MT CHROUSOS, GP BARNES, K LORIAUX, DL FLEISHER, TA AF LAUE, L LOTZE, MT CHROUSOS, GP BARNES, K LORIAUX, DL FLEISHER, TA TI EFFECT OF CHRONIC TREATMENT WITH THE GLUCOCORTICOID ANTAGONIST RU-486 IN MAN - TOXICITY, IMMUNOLOGICAL, AND HORMONAL ASPECTS SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article C1 NCI, SURG BRANCH, BETHESDA, MD 20892 USA. NIH, DEPT CLIN PATHOL, IMMUNOL SERV, BETHESDA, MD 20892 USA. RP LAUE, L (reprint author), NICHHD, DEV ENDOCRINOL BRANCH, BLDG 10, ROOM 10N262, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA. NR 37 TC 66 Z9 67 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD DEC PY 1990 VL 71 IS 6 BP 1474 EP 1480 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL033 UT WOS:A1990EL03300013 PM 2172280 ER PT J AU FEUILLAN, PP SHAWKER, T ROSE, SR JONES, J JEEVANRAM, RK NISULA, BC AF FEUILLAN, PP SHAWKER, T ROSE, SR JONES, J JEEVANRAM, RK NISULA, BC TI THYROID ABNORMALITIES IN THE MCCUNE-ALBRIGHT SYNDROME - ULTRASONOGRAPHY AND HORMONAL STUDIES SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article C1 NIH, DEPT RADIOL, BETHESDA, MD 20892 USA. RP FEUILLAN, PP (reprint author), NICHHD, DEV ENDOCRINOL BRANCH, BLDG 10, ROOM 10N262, BETHESDA, MD 20892 USA. NR 17 TC 43 Z9 43 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD DEC PY 1990 VL 71 IS 6 BP 1596 EP 1601 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL033 UT WOS:A1990EL03300032 PM 2229316 ER PT J AU EASTMAN, RC CARSON, RE GORDON, MR BERG, GW LILLIOJA, S LARSON, SM ROTH, J AF EASTMAN, RC CARSON, RE GORDON, MR BERG, GW LILLIOJA, S LARSON, SM ROTH, J TI BRAIN GLUCOSE-METABOLISM IN NONINSULIN-DEPENDENT DIABETES-MELLITUS - A STUDY IN PIMA-INDIANS USING POSITRON EMISSION TOMOGRAPHY DURING HYPERINSULINEMIA WITH EUGLYCEMIC GLUCOSE CLAMP SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article C1 GEORGETOWN UNIV, SCH MED, DEPT MED, DIV ENDOCRINOL & METAB, WASHINGTON, DC 20007 USA. NIH, CTR CLIN, DEPT NUCL MED, BETHESDA, MD 20892 USA. NIH, CTR CLIN, DEPT NURSING, BETHESDA, MD 20892 USA. NIDDKD, INDIAN MED CTR, PHOENIX, AZ 85016 USA. MEM SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA. RP EASTMAN, RC (reprint author), NIDDKD, CTR CLIN, DIABET BRANCH, BLDG 10, ROOM 8S-243, BETHESDA, MD 20892 USA. RI Lillioja, Stephen/A-8185-2012; Carson, Richard/H-3250-2011; OI Carson, Richard/0000-0002-9338-7966; Lillioja, Stephen/0000-0001-5333-5240 NR 67 TC 25 Z9 25 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD DEC PY 1990 VL 71 IS 6 BP 1602 EP 1610 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL033 UT WOS:A1990EL03300033 PM 2229317 ER PT J AU VIALLET, J SHARONI, Y FRUCHT, H JENSEN, RT MINNA, JD SAUSVILLE, EA AF VIALLET, J SHARONI, Y FRUCHT, H JENSEN, RT MINNA, JD SAUSVILLE, EA TI CHOLERA-TOXIN INHIBITS SIGNAL TRANSDUCTION BY SEVERAL MITOGENS AND THE INVITRO GROWTH OF HUMAN SMALL-CELL LUNG-CANCER SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article C1 NCI,USN,MED ONCOL BRANCH,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NIDDKD,DIGEST DIS BRANCH,BETHESDA,MD 20892. GEORGETOWN UNIV,SCH MED,VINCENT T LOMBARDI CANC RES CTR,DEPT MED,DIV MED ONCOL,WASHINGTON,DC 20007. FU NCRR NIH HHS [RR5360] NR 45 TC 35 Z9 35 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1990 VL 86 IS 6 BP 1904 EP 1912 DI 10.1172/JCI114923 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EL763 UT WOS:A1990EL76300019 PM 2174911 ER PT J AU WAKEFIELD, LM WINOKUR, TS HOLLANDS, RS CHRISTOPHERSON, K LEVINSON, AD SPORN, MB AF WAKEFIELD, LM WINOKUR, TS HOLLANDS, RS CHRISTOPHERSON, K LEVINSON, AD SPORN, MB TI RECOMBINANT LATENT TRANSFORMING GROWTH FACTOR-BETA-1 HAS A LONGER PLASMA HALF-LIFE IN RATS THAN ACTIVE TRANSFORMING GROWTH FACTOR-BETA-1, AND A DIFFERENT TISSUE DISTRIBUTION SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article C1 GENENTECH INC,DEPT CELL GENET,SAN FRANCISCO,CA 94080. RP WAKEFIELD, LM (reprint author), NCI,CHEMOPREVENT LAB,BLDG 41,ROOM B1111,BETHESDA,MD 20892, USA. NR 27 TC 193 Z9 196 U1 0 U2 3 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1990 VL 86 IS 6 BP 1976 EP 1984 DI 10.1172/JCI114932 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EL763 UT WOS:A1990EL76300028 PM 2254455 ER PT J AU WALDMANN, TA TERRY, WD AF WALDMANN, TA TERRY, WD TI FAMILIAL HYPERCATABOLIC HYPOPROTEINEMIA - A DISORDER OF ENDOGENOUS CATABOLISM OF ALBUMIN AND IMMUNOGLOBULIN SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article C1 NCI,IMMUNOL BRANCH,BETHESDA,MD 20892. RP WALDMANN, TA (reprint author), NCI,METAB BRANCH,BLDG 10,ROOM 4N115,BETHESDA,MD 20892, USA. NR 21 TC 39 Z9 39 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1990 VL 86 IS 6 BP 2093 EP 2098 DI 10.1172/JCI114947 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EL763 UT WOS:A1990EL76300043 PM 2254461 ER PT J AU LILLEHOJ, EP ALEXANDER, SS DUBRULE, CJ WIKTOR, S ADAMS, R TAI, CC MANNS, A BLATTNER, WA AF LILLEHOJ, EP ALEXANDER, SS DUBRULE, CJ WIKTOR, S ADAMS, R TAI, CC MANNS, A BLATTNER, WA TI DEVELOPMENT AND EVALUATION OF A HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I SEROLOGIC CONFIRMATORY ASSAY INCORPORATING A RECOMBINANT ENVELOPE POLYPEPTIDE SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article C1 NCI,BETHESDA,MD 20892. RP LILLEHOJ, EP (reprint author), CAMBRIDGE BIOTECH CORP,ROCKVILLE,MD 20850, USA. NR 36 TC 69 Z9 70 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1990 VL 28 IS 12 BP 2653 EP 2658 PG 6 WC Microbiology SC Microbiology GA EJ459 UT WOS:A1990EJ45900014 PM 2279997 ER PT J AU LEE, JW MELCHER, GA RINALDI, MG PIZZO, PA WALSH, TJ AF LEE, JW MELCHER, GA RINALDI, MG PIZZO, PA WALSH, TJ TI PATTERNS OF MORPHOLOGICAL VARIATION AMONG ISOLATES OF TRICHOSPORON-BEIGELII SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note C1 NCI,PEDIAT BRANCH,INFECT DIS SECT,BETHESDA,MD 20892. UNIV TEXAS,DEPT PATHOL,SAN ANTONIO,TX 78285. WILFORD HALL USAF MED CTR,INFECT DIS SECT,LACKLAND AFB,TX 78236. AUDIE L MURPHY MEM VET ADM MED CTR,LAB SERV,SAN ANTONIO,TX 78284. NR 12 TC 36 Z9 37 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1990 VL 28 IS 12 BP 2823 EP 2827 PG 5 WC Microbiology SC Microbiology GA EJ459 UT WOS:A1990EJ45900049 PM 2280018 ER PT J AU DIBISCEGLIE, AM HOOFNAGLE, JH AF DIBISCEGLIE, AM HOOFNAGLE, JH TI HEPATITIS-B VIRUS-REPLICATION WITHIN THE HUMAN SPLEEN SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note RP DIBISCEGLIE, AM (reprint author), NIDDKD,LIVER DIS SECT,BETHESDA,MD 20892, USA. NR 22 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1990 VL 28 IS 12 BP 2850 EP 2852 PG 3 WC Microbiology SC Microbiology GA EJ459 UT WOS:A1990EJ45900057 PM 2280024 ER PT J AU MELLMAN, TA UHDE, TW AF MELLMAN, TA UHDE, TW TI PATIENTS WITH FREQUENT SLEEP PANIC - CLINICAL FINDINGS AND RESPONSE TO MEDICATION TREATMENT SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID DISORDER; ATTACKS; ANXIETY AB The authors present 12 cases of panic disorder patients whose sleep panic attacks represented their primary complaint at the time of admission. The patients averaged 18 sleep panic attacks per month before admission. Seven patients were treated with tricyclic antidepressants and demonstrated marked global clinical improvement and a reduction in the frequency of sleep panic attacks. The clinical and theoretical implications of these preliminary findings are discussed within the context of current theories regarding the spontaneous nature of panic attacks. C1 NIMH,ANXIETY & AFFECT DIS SECT,9000 ROCKVILLE PIKE,BLDG 10,ROOM 3S-239,BETHESDA,MD 20892. NR 16 TC 45 Z9 45 U1 0 U2 1 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 1990 VL 51 IS 12 BP 513 EP 516 PG 4 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA EQ992 UT WOS:A1990EQ99200005 PM 2258365 ER PT J AU ASANUMA, C PORTER, LL AF ASANUMA, C PORTER, LL TI LIGHT AND ELECTRON-MICROSCOPIC EVIDENCE FOR A GABAERGIC PROJECTION FROM THE CAUDAL BASAL FOREBRAIN TO THE THALAMIC RETICULAR NUCLEUS IN RATS SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANAT,BETHESDA,MD 20814. RP ASANUMA, C (reprint author), NIMH,NEUROPHYSIOL LAB,POOLESVILLE,MD 20837, USA. FU NINDS NIH HHS [NS 27038] NR 83 TC 76 Z9 76 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9967 J9 J COMP NEUROL JI J. Comp. Neurol. PD DEC 1 PY 1990 VL 302 IS 1 BP 159 EP 172 DI 10.1002/cne.903020112 PG 14 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA EL761 UT WOS:A1990EL76100011 PM 1707896 ER PT J AU RAYBECK, D HERRMANN, D AF RAYBECK, D HERRMANN, D TI A CROSS-CULTURAL EXAMINATION OF SEMANTIC RELATIONS SO JOURNAL OF CROSS-CULTURAL PSYCHOLOGY LA English DT Article C1 NIMH,BETHESDA,MD 20892. RP RAYBECK, D (reprint author), HAMILTON COLL,DEPT ANTHROPOL,CLINTON,NY 13323, USA. NR 30 TC 9 Z9 9 U1 0 U2 0 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0022-0221 J9 J CROSS CULT PSYCHOL JI J. Cross-Cult. Psychol. PD DEC PY 1990 VL 21 IS 4 BP 452 EP 473 DI 10.1177/0022022190214004 PG 22 WC Psychology, Social SC Psychology GA EJ217 UT WOS:A1990EJ21700004 ER PT J AU FUKASE, Y EANES, ED TAKAGI, S CHOW, LC BROWN, WE AF FUKASE, Y EANES, ED TAKAGI, S CHOW, LC BROWN, WE TI SETTING REACTIONS AND COMPRESSIVE STRENGTHS OF CALCIUM-PHOSPHATE CEMENTS SO JOURNAL OF DENTAL RESEARCH LA English DT Article C1 NATL INST STANDARDS & TECHNOL,AMER DENT ASSOC HLTH FDN,PAFFENBARGER RES CTR,GAITHERSBURG,MD 20899. NIDR,BETHESDA,MD 20892. FU NIDCR NIH HHS [DE05030] NR 14 TC 208 Z9 217 U1 4 U2 37 PU AMER ASSOC DENTAL RESEARCH PI ALEXANDRIA PA 1619 DUKE ST, ALEXANDRIA, VA 22314 SN 0022-0345 J9 J DENT RES JI J. Dent. Res. PD DEC PY 1990 VL 69 IS 12 BP 1852 EP 1856 DI 10.1177/00220345900690121201 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EN816 UT WOS:A1990EN81600012 PM 2250090 ER PT J AU AGUI, T OKA, M YAMADA, T SAKAI, T IZUMI, K ISHIDA, Y HIMENO, K MATSUMOTO, K AF AGUI, T OKA, M YAMADA, T SAKAI, T IZUMI, K ISHIDA, Y HIMENO, K MATSUMOTO, K TI MATURATIONAL ARREST FROM CD4+8+ TO CD4+8- THYMOCYTES IN A MUTANT STRAIN (LEC) OF RAT SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article C1 UNIV TOKUSHIMA,SCH MED,INST ANIM EXPERIMENTAT,KURAMOTO 3,TOKUSHIMA 770,JAPAN. UNIV TOKUSHIMA,SCH MED,DEPT PARASITOL & IMMUNOL,TOKUSHIMA 770,JAPAN. UNIV TOKUSHIMA,SCH MED,DEPT PATHOL,TOKUSHIMA 770,JAPAN. NIAID,IMMUNOL LAB,BETHESDA,MD 20892. NR 34 TC 50 Z9 50 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1990 VL 172 IS 6 BP 1615 EP 1624 DI 10.1084/jem.172.6.1615 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL849 UT WOS:A1990EL84900010 PM 2147947 ER PT J AU EHRENREICH, H ANDERSON, RW FOX, CH RIECKMANN, P HOFFMAN, GS TRAVIS, WD COLIGAN, JE KEHRL, JH FAUCI, AS AF EHRENREICH, H ANDERSON, RW FOX, CH RIECKMANN, P HOFFMAN, GS TRAVIS, WD COLIGAN, JE KEHRL, JH FAUCI, AS TI ENDOTHELINS, PEPTIDES WITH POTENT VASOACTIVE PROPERTIES, ARE PRODUCED BY HUMAN MACROPHAGES SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article C1 NCI,PATHOL LAB,BETHESDA,MD 20892. RP EHRENREICH, H (reprint author), NIAID,IMMUNOREGULAT LAB,BLDG 10,ROOM 11B-13,BETHESDA,MD 20892, USA. OI Kehrl, John/0000-0002-6526-159X NR 32 TC 458 Z9 462 U1 0 U2 2 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1990 VL 172 IS 6 BP 1741 EP 1748 DI 10.1084/jem.172.6.1741 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL849 UT WOS:A1990EL84900024 PM 1701822 ER PT J AU NAKATA, M SMYTH, MJ NORIHISA, Y KAWASAKI, A SHINKAI, Y OKUMURA, K YAGITA, H AF NAKATA, M SMYTH, MJ NORIHISA, Y KAWASAKI, A SHINKAI, Y OKUMURA, K YAGITA, H TI CONSTITUTIVE EXPRESSION OF PORE-FORMING PROTEIN IN PERIPHERAL-BLOOD GAMMA-DELTA-T-CELLS - IMPLICATION FOR THEIR CYTOTOXIC ROLE INVIVO SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Note C1 JUNTENDO UNIV,SCH MED,DEPT IMMUNOL,2-1-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN. NCI,FREDERICK CANC RES & DEV CTR,EXPTL IMMUNOL LAB,FREDERICK,MD 21701. RI Shinkai, Yoichi/N-3909-2014; Smyth, Mark/H-8709-2014 OI Shinkai, Yoichi/0000-0002-6051-2484; Smyth, Mark/0000-0001-7098-7240 NR 16 TC 107 Z9 109 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1990 VL 172 IS 6 BP 1877 EP 1880 DI 10.1084/jem.172.6.1877 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL849 UT WOS:A1990EL84900041 PM 2124255 ER PT J AU FENDLER, K FROEHLICH, J JARUSCHEWSKI, S HOBBS, A ALBERS, W BAMBERG, E GRELL, E AF FENDLER, K FROEHLICH, J JARUSCHEWSKI, S HOBBS, A ALBERS, W BAMBERG, E GRELL, E TI CORRELATION OF CHARGE TRANSLOCATION WITH THE REACTION CYCLE OF THE NA,K-ATPASE SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 MAX PLANCK INST BIOPHYS,W-6000 FRANKFURT 70,GERMANY. NIH,BALTIMORE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A76 EP A76 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200131 ER PT J AU COLLINS, PL HILL, MG JOHNSON, PR AF COLLINS, PL HILL, MG JOHNSON, PR TI THE 2 OPEN READING FRAMES OF THE 22K MESSENGER-RNA OF HUMAN RESPIRATORY SYNCYTIAL VIRUS - SEQUENCE COMPARISON OF ANTIGENIC SUBGROUP-A AND SUBGROUP-B AND EXPRESSION INVITRO SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID NUCLEOTIDE-SEQUENCE; G-GLYCOPROTEIN; GENE-OVERLAP; PROTEIN; IDENTIFICATION; CONSERVATION; RELATEDNESS; DIVERGENCE; SUBTYPES; PROVIDES AB The sequence of the 22K mRNA of strain 18537 of antigenic subgroup B of human respiratory syncytial virus (RSV) was determined by sequencing cloned cDNAs of intracellular mRNA. Comparison with the corresponding sequence of the A2 strain of subgroup A showed that there is 78% nucleotide sequence identity overall, that the amino acid sequence of the 22K protein is 92% identical between subgroups and that the 22K mRNA of both subgroups contains a second, internal, overlapping open reading frame (ORF) whose length, nucleotide sequence and potential translational start and stop sites were highly conserved and whose predicted product has 62% amino acid identity between subgroups. Sequence analysis of 36 cDNAs of intracellular 22K mRNA of strain A2 did not detect nucleotide insertions or deletions in the region of overlap between the two ORFs, indicating that the majority of intracellular 22K mRNA is a faithful copy containing the two distinct ORFs. Translation in vitro of mRNAs transcribed from engineered cDNAs showed that an mRNA which contained only the second, internal ORF directed the synthesis of a previously unidentified polypeptide of the predicted size, whereas mRNA representing the complete gene directed the synthesis of both the 22K protein and the product of the internal ORF. This latter species was synthesized in vitro as a discrete, separate protein rather than as a fusion protein. It is not yet known whether this protein is synthesized in RSV-infected cells. C1 GEORGETOWN UNIV,SCH MED & DENT,NIAID,ROCKVILLE,MD 20852. RP COLLINS, PL (reprint author), NIAID,INFECT DIS LAB,BETHESDA,MD 20892, USA. RI Johnson, Philip/A-6892-2009 NR 34 TC 43 Z9 45 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD DEC PY 1990 VL 71 BP 3015 EP 3020 DI 10.1099/0022-1317-71-12-3015 PN 12 PG 6 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA EP009 UT WOS:A1990EP00900030 PM 2273393 ER PT J AU WENTHOLD, RJ HAMPSON, DR WADA, K HUNTER, C OBERDORFER, MD DECHESNE, CJ AF WENTHOLD, RJ HAMPSON, DR WADA, K HUNTER, C OBERDORFER, MD DECHESNE, CJ TI ISOLATION, LOCALIZATION, AND CLONING OF A KAINIC ACID BINDING-PROTEIN FROM FROG BRAIN SO JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY LA English DT Article; Proceedings Paper CT SYMP AT THE 3RD JOINT MEETING OF THE JAPAN SOC OF HISTOCHEMISTRY AND THE HISTOCHEMICAL SOC : EXCITATORY AMINO ACID NEUROTRANSMITTERS AND THEIR RECEPTORS CY AUG 08-11, 1990 CL SEATTLE, WA SP JAPAN SOC HISTOCHEM, HISTOCHEM SOC RP WENTHOLD, RJ (reprint author), NATL INST DEAFNESS & OTHER COMMUN DISORDERS,MOLEC OTOL LAB,NEUROCHEM SECT,BLDG 36,ROOM 5D08,BETHESDA,MD 20892, USA. NR 18 TC 10 Z9 10 U1 0 U2 0 PU HISTOCHEMICAL SOC INC PI NEW YORK PA MT SINAI MEDICAL CENTER 19 EAST 98TH ST SUTIE 9G, NEW YORK, NY 10029 SN 0022-1554 J9 J HISTOCHEM CYTOCHEM JI J. Histochem. Cytochem. PD DEC PY 1990 VL 38 IS 12 BP 1717 EP 1723 PG 7 WC Cell Biology SC Cell Biology GA EJ531 UT WOS:A1990EJ53100002 PM 2174936 ER PT J AU LEES, A MORRIS, SC THYPHRONITIS, G HOLMES, JM INMAN, JK FINKELMAN, FD AF LEES, A MORRIS, SC THYPHRONITIS, G HOLMES, JM INMAN, JK FINKELMAN, FD TI RAPID STIMULATION OF LARGE SPECIFIC ANTIBODY-RESPONSES WITH CONJUGATES OF ANTIGEN AND ANTI-IGD ANTIBODY SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892. RP LEES, A (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,ROOM A3060,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NIAID NIH HHS [AI 21328] NR 36 TC 34 Z9 34 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3594 EP 3600 PG 7 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100009 PM 2246504 ER PT J AU MURAKAMI, S MIYAKE, K JUNE, CH KINCADE, PW HODES, RJ AF MURAKAMI, S MIYAKE, K JUNE, CH KINCADE, PW HODES, RJ TI IL-5 INDUCES A PGP-1 (CD44) BRIGHT B-CELL SUBPOPULATION THAT IS HIGHLY ENRICHED IN PROLIFERATIVE AND IG SECRETORY ACTIVITY AND BINDS TO HYALURONATE SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK 73104. USN,MED RES INST,BETHESDA,MD 20814. RP MURAKAMI, S (reprint author), NCI,EXPTL IMMUNOL BRANCH,BLDG 10,ROOM 4B17,BETHESDA,MD 20892, USA. FU NIAID NIH HHS [AI-19884, AI-20069] NR 46 TC 110 Z9 111 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3618 EP 3627 PG 10 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100012 PM 2246506 ER PT J AU RICO, MJ KORMAN, NJ STANLEY, JR TANAKA, T HALL, RP AF RICO, MJ KORMAN, NJ STANLEY, JR TANAKA, T HALL, RP TI IGG ANTIBODIES FROM PATIENTS WITH BULLOUS PEMPHIGOID BIND TO LOCALIZED EPITOPES ON SYNTHETIC PEPTIDES ENCODED BY BULLOUS PEMPHIGOID ANTIGEN CDNA SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 DUKE UNIV,MED CTR,DEPT MED,DIV DERMATOL,DURHAM,NC 27710. VET ADM MED CTR,DURHAM,NC 27710. NCI,DERMATOL BRANCH,BETHESDA,MD 20892. FU NIAMS NIH HHS [ARM-347180] NR 24 TC 36 Z9 36 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3728 EP 3733 PG 6 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100027 PM 1700993 ER PT J AU CASE, JP LAFYATIS, R KUMKUMIAN, GK REMMERS, EF WILDER, RL AF CASE, JP LAFYATIS, R KUMKUMIAN, GK REMMERS, EF WILDER, RL TI IL-1 REGULATION OF TRANSIN STROMELYSIN TRANSCRIPTION IN RHEUMATOID SYNOVIAL FIBROBLASTS APPEARS TO INVOLVE 2 ANTAGONISTIC TRANSDUCTION PATHWAYS, AN INHIBITORY, PROSTAGLANDIN-DEPENDENT PATHWAY MEDIATED BY CAMP, AND A STIMULATORY, PROTEIN KINASE-C-DEPENDENT PATHWAY SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892. NR 53 TC 81 Z9 81 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3755 EP 3761 PG 7 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100031 PM 2174073 ER PT J AU HOHMAN, RJ HULTSCH, T TALBOT, E AF HOHMAN, RJ HULTSCH, T TALBOT, E TI IGE RECEPTOR-MEDIATED PHOSPHATIDYLINOSITOL HYDROLYSIS AND EXOCYTOSIS FROM RAT BASOPHILIC LEUKEMIA-CELLS ARE INDEPENDENT OF EXTRACELLULAR CA-2+ IN A HYPOTONIC BUFFER CONTAINING A HIGH-CONCENTRATION OF K+1 SO JOURNAL OF IMMUNOLOGY LA English DT Article RP HOHMAN, RJ (reprint author), NIH,CLIN INVEST LAB,ALLERG DIS SECT,BLDG 10,ROOM 11C215,BETHESDA,MD 20892, USA. NR 26 TC 7 Z9 7 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3876 EP 3882 PG 7 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100048 PM 2147206 ER PT J AU SHER, A COFFMAN, RL HIENY, S CHEEVER, AW AF SHER, A COFFMAN, RL HIENY, S CHEEVER, AW TI ABLATION OF EOSINOPHIL AND IGE RESPONSES WITH ANTI-IL-5 OR ANTI-IL-4 ANTIBODIES FAILS TO AFFECT IMMUNITY AGAINST SCHISTOSOMA-MANSONI IN THE MOUSE SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NIAID,PARASIT DIS LAB,HOST PARASITE RELAT SECT,BETHESDA,MD 20892. DNAX RES INST MOLEC & CELLULAR BIOL INC,DEPT IMMUNOL,PALO ALTO,CA 94304. RP SHER, A (reprint author), NIAID,IMMUNOL & CELL BIOL SECT,BLDG 4,ROOM 126,BETHESDA,MD 20892, USA. NR 31 TC 249 Z9 249 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3911 EP 3916 PG 6 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100053 PM 2123226 ER PT J AU STEEL, C LIMBERGER, RJ MCREYNOLDS, LA OTTESEN, EA NUTMAN, TB AF STEEL, C LIMBERGER, RJ MCREYNOLDS, LA OTTESEN, EA NUTMAN, TB TI B-CELL RESPONSES TO PARAMYOSIN - ISOTYPIC ANALYSIS AND EPITOPE MAPPING OF FILARIAL PARAMYOSIN IN PATIENTS WITH ONCHOCERCIASIS SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NEW ENGLAND BIOLABS INC,BEVERLY,MA 01915. RP STEEL, C (reprint author), NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 37 TC 41 Z9 42 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1990 VL 145 IS 11 BP 3917 EP 3923 PG 7 WC Immunology SC Immunology GA EK391 UT WOS:A1990EK39100054 PM 1701001 ER PT J AU PINCUS, SH WEHRLY, K AF PINCUS, SH WEHRLY, K TI AZT DEMONSTRATES ANTI-HIV-1 ACTIVITY IN PERSISTENTLY INFECTED CELL-LINES - IMPLICATIONS FOR COMBINATION CHEMOTHERAPY AND IMMUNOTHERAPY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article C1 NIAID,ROCKY MT LABS,PERSISTANT VIRAL DIS LAB,HAMILTON,MT 59840. RP PINCUS, SH (reprint author), NIAID,ROCKY MT LABS,MICROBIAL STRUCT & FUNCT LAB,HAMILTON,MT 59840, USA. NR 25 TC 30 Z9 30 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1990 VL 162 IS 6 BP 1233 EP 1238 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EK574 UT WOS:A1990EK57400002 PM 2230256 ER PT J AU BASSETSEGUIN, N CAUGHMAN, SW YANCEY, KB AF BASSETSEGUIN, N CAUGHMAN, SW YANCEY, KB TI A-431 CELLS AND HUMAN KERATINOCYTES SYNTHESIZE AND SECRETE THE 3RD COMPONENT OF COMPLEMENT SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article ID EPIDERMAL BASEMENT-MEMBRANE; EXPRESSION; PROTEIN; C3D,G AB Biosynthetic radiolabeling studies demonstrate that A-431 cells, a human epidermoid carcinoma cell line, and human keratinocytes synthesize and secrete C3 as two disulfide-linked polypeptide chains of 120 and 75 kD. Moreover, epithelial cell-derived C3 co-migrates in SDS-PAGE with that produced by HepG2 cells, a human hepatoma cell line previously used to elucidate complement component biosynthesis. Pulse-chase studies in A-431 cells demonstrate that epithelial cell-derived C3 is produced as a 195-kD precursor molecule, pro-C3, which is processed intracellularly by limited proteolysis into 120- and 75-kD C3 alpha and beta chains. Comparative studies demonstrate that A-431 cell-derived C3 is synthesized, processed, and secreted in parallel but in lower quantity than that produced by HepG2 cells. Treatment of biosynthetically labeled A-431 cell culture supernatants with normal human serum and zymosan produces C3 alpha chain cleavage and specific C3 fragments that are not present in control culture supernatants treated with heat-inactivated human serum and zymosan. Northern blot analysis of total cellular RNA extracted from A-431 cells, human keratinocytes, and HepG2 cells reveals qualitative identity of a 5.1-kb C3 mRNA species in these three cell types. Epithelial cell-derived C3 may play an important role in local inflammatory and immunologic reactions including such reactions in human skin. Moreover, epithelial cell C3 synthesis may have direct relevance to the recent demonstration of C3d,g within selected normal primate epithelial basement membranes, including epidermal basement membrane. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT DERMATOL,B4080 USUHS,4301,4301 JONES BRIDGE RD,BETHESDA,MD 20814. NCI,DERMATOL BRANCH,BETHESDA,MD 20892. FU NIAMS NIH HHS [AR 37446] NR 16 TC 64 Z9 65 U1 0 U2 1 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD DEC PY 1990 VL 95 IS 6 BP 621 EP 625 DI 10.1111/1523-1747.ep12513524 PG 5 WC Dermatology SC Dermatology GA EP025 UT WOS:A1990EP02500001 PM 2250103 ER PT J AU PRODOUZ, KN HABRAKEN, JW MOROFF, G AF PRODOUZ, KN HABRAKEN, JW MOROFF, G TI RESISTANCE OF PLATELET PROTEINS TO EFFECTS OF IONIZING-RADIATION SO JOURNAL OF LABORATORY AND CLINICAL MEDICINE LA English DT Article C1 AMER RED CROSS,BIOMED RES & DEV LAB,JEROME HOLLAND LABS,ROCKVILLE,MD. RP PRODOUZ, KN (reprint author), US FDA,CTR BIOL EVALUAT & RES,NIH BLDG 29,ROOM 329,8800 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 17 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-2143 J9 J LAB CLIN MED JI J. Lab. Clin. Med. PD DEC PY 1990 VL 116 IS 6 BP 766 EP 770 PG 5 WC Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & Experimental SC Medical Laboratory Technology; General & Internal Medicine; Research & Experimental Medicine GA EM314 UT WOS:A1990EM31400005 PM 2246551 ER PT J AU KIM, HY SALEM, N AF KIM, HY SALEM, N TI SEPARATION OF LIPID CLASSES BY SOLID-PHASE EXTRACTION SO JOURNAL OF LIPID RESEARCH LA English DT Note DE PHOSPHOLIPIDS; NEUTRAL LIPIDS; THERMOSPRAY LC-MS ID CHROMATOGRAPHY MASS-SPECTROMETRY; PHOSPHOLIPIDS AB A rapid and reliable method for the separation of lipid classes is described using aminopropyl disposable columns. This method is a modification to an existing procedure that allows the separation of both neutral and acidic phospholipid fractions and a high recovery of the latter. Acidic phospholipids were eluted with a mixture of hexane-2-propanol-ethanol-0.1 M ammonium acetate-formic acid 420:350:100:50:0.5 containing 5% phosphoric acid after neutral phospholipids had been eluted with methanol. It was verified that extremely high recoveries of cholesterol (CH), triglycerides (TG), free fatty acids (FFA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidic acid (PA), sphingomyelin (SM), and cerebrosides were obtained with this method. In addition, there appeared to be no preferential losses or degradation of any particular molecular species as the fatty acid distribution of bovine brain PS and the molecular species profile of plant PI were unaltered by the procedure. Depending on the tissue, this method may yield fractions containing pure lipid classes and/or simple mixtures of lipid classes of similar polarity. These fractions may then be more easily separated by thin-layer chromatography or high performance liquid chromatography for complete lipid class analysis. RP KIM, HY (reprint author), NIAAA,DICBR,CLIN STUDIES LAB,ANALYT CHEM SECT,BLDG 10,ROOM 3C-102,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 9 TC 106 Z9 107 U1 2 U2 19 PU LIPID RESEARCH INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0022-2275 J9 J LIPID RES JI J. Lipid Res. PD DEC PY 1990 VL 31 IS 12 BP 2285 EP 2289 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA ER669 UT WOS:A1990ER66900018 PM 2090722 ER PT J AU DAVIS, DG AF DAVIS, DG TI SIMPLIFICATION OF PROTON-DETECTED, NATURAL ABUNDANCE C-13 CORRELATION SPECTRA OF PROTEINS VIA MULTIPLET EDITING SO JOURNAL OF MAGNETIC RESONANCE LA English DT Note ID SHIFT CORRELATION; NMR-SPECTROSCOPY; HETERONUCLEAR; ASSIGNMENTS; NUCLEI RP DAVIS, DG (reprint author), NIEHS,MOLEC BIOPHYS LAB,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 23 TC 18 Z9 18 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-2364 J9 J MAGN RESON PD DEC PY 1990 VL 90 IS 3 BP 589 EP 596 DI 10.1016/0022-2364(90)90067-J PG 8 WC Biochemical Research Methods; Physics, Atomic, Molecular & Chemical; Spectroscopy SC Biochemistry & Molecular Biology; Physics; Spectroscopy GA EQ750 UT WOS:A1990EQ75000019 ER PT J AU JUNG, G URRUTIA, RA HAMMER, JA AF JUNG, G URRUTIA, RA HAMMER, JA TI MYOSIN-I FUNCTION INVIVO SO JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY LA English DT Meeting Abstract C1 NHLBI,CELL BIOL LAB,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0142-4319 J9 J MUSCLE RES CELL M JI J. Muscle Res. Cell Motil. PD DEC PY 1990 VL 11 IS 6 BP 540 EP 540 PG 1 WC Cell Biology SC Cell Biology GA EU140 UT WOS:A1990EU14000023 ER PT J AU KORN, ED AF KORN, ED TI AMEBA MYOSINS - REGULATION, LOCALIZATION AND POSSIBLE FUNCTIONS SO JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY LA English DT Meeting Abstract C1 NHLBI,CELL BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0142-4319 J9 J MUSCLE RES CELL M JI J. Muscle Res. Cell Motil. PD DEC PY 1990 VL 11 IS 6 BP 540 EP 541 PG 2 WC Cell Biology SC Cell Biology GA EU140 UT WOS:A1990EU14000024 ER PT J AU SELLERS, JR KACHAR, B AF SELLERS, JR KACHAR, B TI BIDIRECTIONAL MOVEMENT OF FLUORESCENTLY-LABELED ACTIN-FILAMENTS ON SINGLE THICK FILAMENTS FROM CLAM MUSCLE SO JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NIDCD,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0142-4319 J9 J MUSCLE RES CELL M JI J. Muscle Res. Cell Motil. PD DEC PY 1990 VL 11 IS 6 BP 541 EP 541 PG 1 WC Cell Biology SC Cell Biology GA EU140 UT WOS:A1990EU14000027 ER PT J AU KAWAMOTO, S KELLEY, CA CONTI, MA SIMONS, M WEIR, L ADELSTEIN, RS AF KAWAMOTO, S KELLEY, CA CONTI, MA SIMONS, M WEIR, L ADELSTEIN, RS TI EXPRESSION AND PHOSPHORYLATION OF VERTEBRATE MYOSIN HEAVY-CHAINS SO JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0142-4319 J9 J MUSCLE RES CELL M JI J. Muscle Res. Cell Motil. PD DEC PY 1990 VL 11 IS 6 BP 542 EP 542 PG 1 WC Cell Biology SC Cell Biology GA EU140 UT WOS:A1990EU14000029 ER PT J AU OLASMAA, M ROTHSTEIN, JD GUIDOTTI, A WEBER, RJ PAUL, SM SPECTOR, S ZENEROLI, ML BARALDI, M COSTA, E AF OLASMAA, M ROTHSTEIN, JD GUIDOTTI, A WEBER, RJ PAUL, SM SPECTOR, S ZENEROLI, ML BARALDI, M COSTA, E TI ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGANDS IN HUMAN AND ANIMAL HEPATIC-ENCEPHALOPATHY SO JOURNAL OF NEUROCHEMISTRY LA English DT Article C1 GEORGETOWN UNIV,SCH MED,FIDIA GEORGETOWN INST NEUROSCI,3900 RESERVOIR RD NW,WASHINGTON,DC 20007. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. NIDDK,NEUROIMMUNOL UNIT,MED CHEM LAB,BETHESDA,MD. NIMH,BETHESDA,MD 20892. VANDERBILT UNIV,DEPT PHARMACOL & PSYCHIAT,NASHVILLE,TN 37240. UNIV MODENA,DEPT PHARMACOL & PHARMACOGNOSY,I-41100 MODENA,ITALY. RI rothstein, jeffrey/C-9470-2013 FU NINDS NIH HHS [1 K08 NS01355-01] NR 44 TC 109 Z9 113 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD DEC PY 1990 VL 55 IS 6 BP 2015 EP 2023 DI 10.1111/j.1471-4159.1990.tb05790.x PG 9 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA EK015 UT WOS:A1990EK01500027 PM 2172467 ER PT J AU HALPERN, JL HABIG, WH TRENCHARD, H RUSSELL, JT AF HALPERN, JL HABIG, WH TRENCHARD, H RUSSELL, JT TI EFFECT OF TETANUS TOXIN ON OXYTOCIN AND VASOPRESSIN RELEASE FROM NERVE-ENDINGS OF THE NEUROHYPOPHYSIS SO JOURNAL OF NEUROCHEMISTRY LA English DT Article C1 NICHHD,DEV NEUROBIOL LAB,BETHESDA,MD 20892. RP HALPERN, JL (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV BACTERIAL PROD,BLDG 29,ROOM 103,8800 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 38 TC 18 Z9 18 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD DEC PY 1990 VL 55 IS 6 BP 2072 EP 2078 DI 10.1111/j.1471-4159.1990.tb05797.x PG 7 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA EK015 UT WOS:A1990EK01500034 PM 2172468 ER PT J AU VITKOVIC, L KALEBIC, T DECUNHA, A FAUCI, AS AF VITKOVIC, L KALEBIC, T DECUNHA, A FAUCI, AS TI ASTROCYTE-CONDITIONED MEDIUM STIMULATES HIV-1 EXPRESSION IN A CHRONICALLY INFECTED PROMONOCYTE CLONE SO JOURNAL OF NEUROIMMUNOLOGY LA English DT Article RP VITKOVIC, L (reprint author), NIAID,IMMUNOREGULAT LAB,BLDG 10,RM 11B-13,BETHESDA,MD 20892, USA. NR 40 TC 36 Z9 36 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-5728 J9 J NEUROIMMUNOL JI J. Neuroimmunol. PD DEC PY 1990 VL 30 IS 2-3 BP 153 EP 160 DI 10.1016/0165-5728(90)90099-9 PG 8 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA EK297 UT WOS:A1990EK29700007 PM 2229407 ER PT J AU SAHARA, Y XIE, YK BENNETT, GJ AF SAHARA, Y XIE, YK BENNETT, GJ TI INTRACELLULAR RECORDS OF THE EFFECTS OF PRIMARY AFFERENT INPUT IN LUMBAR SPINORETICULAR TRACT NEURONS IN THE CAT SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article ID SPINOTHALAMIC TRACT; RETICULAR-FORMATION; SPINAL NEURONS; BRAIN-STEM; STIMULATION; NOCICEPTION; MECHANISMS; RESPONSES; PROJECT; RAT AB 1. The afferent-evoked synaptic input to lumbar spinal cord (L5-S1) neurons that were activated antidromically from the medial pontomedullary reticular formation (nucleus reticularis gigantocelluaris and vicinity) was investigated with the use of intracellular recordings in pentobarbital sodium-anesthetized cats. 2. Spinoreticular tract (SRT) neurons (n = 33) were categorized into three types ("deep-inhibited," "deep-complex," and "intermediate") on the basis of their locations and of their responses to natural and electrical stimulation. 3. The deep-inhibited-type neurons, located in the medial part of the deeper laminae (approximately VI-VIII), comprised a large component of the sample (20/33). They had no demonstrable excitatory receptive field (RF). However, electrical stimulation of low-threshold cutaneous afferents of hindlimb nerves evoked inhibitory postsynaptic potentials (IPSPs) via an oligosynaptic linkage. High-threshold cutaneous and muscle afferents also evoked IPSPs. 4. In the deep-complex-type neurons (8/33), electrical stimulation of low-threshold cutaneous afferents evoked complex IPSP-excitatory postsynaptic potential (EPSP) sequences. With intense stimuli, long-latency C-fiber-like EPSPs were evoked. Two of these eight neurons were characterized as wide-dynamic-range (WDR) neurons with large, excitatory and inhibitory cutaneous RFs. 5. Intermediate-type neurons (5/33) were concentrated in the lateral spinal gray and relatively superficially (approximately lamina V). These neurons had convergent low- and high-threshold cutaneous inputs (WDR neurons). Electrical stimulation of low-threshold cutaneous afferent fibers from within the excitatory RF evoked mono- or disynaptic EPSPs followed by IPSPs. High-threshold muscle and cutaneous afferents also evoked EPSPs. 6. These results show that SRT neurons have a variety of response characteristics resulting from various degrees of spatial and temporal summation of primary afferent input. Neurons with widespread inhibitory responses but not excitatory drive from the periphery comprise a surprisingly large component of the SRT; the function of these cells is unknown. It is apparent that the spinoreticular projection has considerable functional heterogeneity. C1 NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 30,RM B-20,9000 ROCKVILLE PIKE,BETHESDA,MD 20892. NR 24 TC 9 Z9 9 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-3077 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD DEC PY 1990 VL 64 IS 6 BP 1791 EP 1800 PG 10 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA EP449 UT WOS:A1990EP44900012 PM 2074464 ER PT J AU AGOSTON, DV BRAVO, DT WASCHEK, JA AF AGOSTON, DV BRAVO, DT WASCHEK, JA TI EXPRESSION OF A CHIMERIC VIP GENE IS TARGETED TO THE INTESTINE IN TRANSGENIC MICE SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE CIS-ACTING SEQUENCES; ENHANCER/PROMOTER ELEMENT; NEUROPEPTIDE GENE; VIP EXPRESSION ID NEURO-BLASTOMA CELLS; CHLORAMPHENICOL ACETYLTRANSFERASE; CHROMAFFIN CELLS; MAMMALIAN-CELLS; POLYPEPTIDE VIP; PEPTIDE GENE; BIOSYNTHESIS AB We showed previously that a gene construction that consisted of 5.2 kb of 5' flanking sequence, the first exon, and part of the first intron of the human gene encoding vasoactive intestinal peptide (VIP) fused to the reporter gene chloramphenicol acetyltransferase (CAT) fully mimicked the diverse behavior of the endogenous VIP gene when transfected into subclones of the human neuroblastoma cell line SK-N-SH (Waschek et al., 1988). To determine if the same sequences were sufficient to target expression of a reporter to VIP-producing tissues in the mouse, we initiated a pilot study in which we generated four transgenic mice or mouse lines that contained the VIPCAT fusion gene. Detectable levels of CAT were found in the ileum of either founder or offspring of each of the transgenic mouse lines. In all other tissues tested, CAT activity was either below the level of detection or the transgene was not expressed, with the exception of one mouse in which ectopic expression in the cerebellum was observed. The results indicate that the VIP sequences utilized were sufficient to direct expression of the transgene to the intestine, but not necessarily to other sites of VIP expression. To investigate what specific DNA sequences might confer VIP expression in the intestine and other sites, we analyzed further the VIP gene in SK-N-SH subclones using VIP/luciferase fusion gene constructions. A 0.6 kb DNA fragment located between 4.0 kb and 4.6 kb upstream from the VIP transcriptional start site was found to impart a high level of expression in one subclone and an increased degree of phorbol ester induction in another. These and other data indicate that multiple transcriptional elements control VIP expression in neuroblastoma cells and are candidates as mediators of VIP gene expression in the intact animal. C1 UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,760 WESTWOOD PLAZA,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,DEPT PSYCHIAT,LOS ANGELES,CA 90024. NIMH,CELL BIOL LAB,BETHESDA,MD 20892. FU NICHD NIH HHS [HD 04612, HD 06576] NR 31 TC 18 Z9 18 U1 1 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0360-4012 J9 J NEUROSCI RES JI J. Neurosci. Res. PD DEC PY 1990 VL 27 IS 4 BP 479 EP 486 DI 10.1002/jnr.490270407 PG 8 WC Neurosciences SC Neurosciences & Neurology GA EP665 UT WOS:A1990EP66500006 PM 2079711 ER PT J AU MIURA, SA SCHAPIRO, MB GRADY, CL KUMAR, A SALERNO, JA KOZACHUK, WE WAGNER, E RAPOPORT, SI HORWITZ, B AF MIURA, SA SCHAPIRO, MB GRADY, CL KUMAR, A SALERNO, JA KOZACHUK, WE WAGNER, E RAPOPORT, SI HORWITZ, B TI EFFECT OF GENDER ON GLUCOSE-UTILIZATION RATES IN HEALTHY HUMANS - A POSITRON EMISSION TOMOGRAPHY STUDY SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE POSITRON EMISSION TOMOGRAPHY; DEOXY-GLUCOSE; BRAIN; SEX DIFFERENCES; BRAIN METABOLISM ID CEREBRAL BLOOD-FLOW; SEX-DIFFERENCES; BRAIN ORGANIZATION; DOWNS-SYNDROME; FEMALE RATS; METABOLISM; SPECIALIZATION; HANDEDNESS; MALES; AGE AB Positron emission tomography (PET) was used with 18fluorodeoxyglucose to see if gender differences in resting cerebral glucose utilization could be detected. Thirty-two healthy subjects (15 women and 17 men; age range: 21-38 yr) were examined using a high-resolution PET scanner to determine the regional cerebral metabolic rate for glucose (CMRglc) in 65 gray matter regions of interest. Whole brain CMRglc did not differ significantly between the two genders, nor did any of the regional CMRglc values. Only 1 of 65 ratios of regional-to-whole brain CMRglc differed significantly between men and women, which is consistent with chance. These results indicate that there are no differences in resting regional cerebral glucose utilization between young men and women. C1 NIA,NEUROSCI LAB,BLDG 10,RM 6C-414,BETHESDA,MD 20892. NR 29 TC 42 Z9 42 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0360-4012 J9 J NEUROSCI RES JI J. Neurosci. Res. PD DEC PY 1990 VL 27 IS 4 BP 500 EP 504 DI 10.1002/jnr.490270410 PG 5 WC Neurosciences SC Neurosciences & Neurology GA EP665 UT WOS:A1990EP66500009 PM 2079712 ER PT J AU SUTTON, LN MCLAUGHLIN, AC DANTE, S KOTAPKA, M SINWELL, T MILLS, E AF SUTTON, LN MCLAUGHLIN, AC DANTE, S KOTAPKA, M SINWELL, T MILLS, E TI CEREBRAL VENOUS OXYGEN-CONTENT AS A MEASURE OF BRAIN ENERGY-METABOLISM WITH INCREASED INTRACRANIAL-PRESSURE AND HYPERVENTILATION SO JOURNAL OF NEUROSURGERY LA English DT Article C1 UNIV PENN,SCH MED,PHILADELPHIA,PA 19104. NIAAA,METAB & MOLEC BIOL LAB,ROCKVILLE,MD 20852. RP SUTTON, LN (reprint author), CHILDRENS HOSP PHILADELPHIA,DEPT NEUROSURG,34TH & CIV CTR BLVD,PHILADELPHIA,PA 19104, USA. FU NINDS NIH HHS [NS08803] NR 24 TC 39 Z9 40 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD DEC PY 1990 VL 73 IS 6 BP 927 EP 932 DI 10.3171/jns.1990.73.6.0927 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EK583 UT WOS:A1990EK58300013 PM 2230975 ER PT J AU PHILLIPS, RL LONDON, ED LINKS, JM CASCELLA, NG AF PHILLIPS, RL LONDON, ED LINKS, JM CASCELLA, NG TI PROGRAM FOR PET IMAGE ALIGNMENT - EFFECTS ON CALCULATED DIFFERENCES IN CEREBRAL METABOLIC RATES FOR GLUCOSE SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article C1 JOHNS HOPKINS MED INST,DIV NUCL MED,BALTIMORE,MD 21205. RP PHILLIPS, RL (reprint author), NIDA,ADDICT RES CTR,NEUROPHARMACOL LAB,POB 5180,BALTIMORE,MD 21224, USA. FU NINDS NIH HHS [NS15080] NR 19 TC 21 Z9 21 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD DEC PY 1990 VL 31 IS 12 BP 2052 EP 2057 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN644 UT WOS:A1990EN64400036 PM 2266408 ER PT J AU ABRAMS, SA VIEIRA, NE YERGEY, AL AF ABRAMS, SA VIEIRA, NE YERGEY, AL TI UNEQUAL DISTRIBUTION OF A STABLE ISOTOPIC CALCIUM TRACER BETWEEN CASEIN AND WHEY FRACTIONS OF INFANT FORMULAS, HUMAN-MILK AND COWS MILK SO JOURNAL OF NUTRITION LA English DT Article DE CALCIUM; HUMAN MILK; COWS MILK; INFANT FORMULAS; ISOTOPIC TRACER ID ABSORPTION AB Measurement of calcium absorption with tracers assumes a complete equilibration of tracer with milk calcium. In this study, the equilibration of tracer between the micellar casein and soluble fractions (primarily whey) of infant formulas, human milk and cow's milk was measured in vitro using milk samples enriched with Ca-42 and analyzed by thermal ionization mass spectrometry. Incomplete equilibration of tracer occurred with the micellar casein fraction of all milks. The least equilibration with micellar casein was found with premature infant formula, for which the ratio of slopes of the equilibration lines (whey/casein) was 8.5/1. These differences may be due to Ca-casein binding in cow's milk-based formulas. The effects of the lack of tracer equilibration in vivo cannot be determined. However, unequal bioavailability of casein-vs. whey-bound Ca may exist. C1 CHILDRENS HOSP,NATL MED CTR,WASHINGTON,DC 20010. RP ABRAMS, SA (reprint author), NICHHD,THEORET & PHYS BIOL LAB,BETHESDA,MD 20892, USA. OI Abrams, Steven/0000-0003-4972-9233 NR 21 TC 9 Z9 9 U1 0 U2 1 PU AMER INST NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-3166 J9 J NUTR JI J. Nutr. PD DEC PY 1990 VL 120 IS 12 BP 1672 EP 1676 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA ER673 UT WOS:A1990ER67300010 PM 2262813 ER PT J AU LINDER, BL ESTEBAN, NV YERGEY, AL WINTERER, JC LORIAUX, DL CASSORLA, F AF LINDER, BL ESTEBAN, NV YERGEY, AL WINTERER, JC LORIAUX, DL CASSORLA, F TI CORTISOL PRODUCTION-RATE IN CHILDHOOD AND ADOLESCENCE SO JOURNAL OF PEDIATRICS LA English DT Article C1 NICHHD, DEV ENDOCRINOL BRANCH, BETHESDA, MD 20892 USA. NICHHD, THEORET & PHYS BIOL LAB, BETHESDA, MD 20892 USA. NR 18 TC 116 Z9 121 U1 2 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD DEC PY 1990 VL 117 IS 6 BP 892 EP 896 DI 10.1016/S0022-3476(05)80128-3 PG 5 WC Pediatrics SC Pediatrics GA EM116 UT WOS:A1990EM11600009 PM 2104527 ER PT J AU BROUWERS, P MOSS, H WOLTERS, P EDDY, J BALIS, F POPLACK, DG PIZZO, PA AF BROUWERS, P MOSS, H WOLTERS, P EDDY, J BALIS, F POPLACK, DG PIZZO, PA TI EFFECT OF CONTINUOUS-INFUSION ZIDOVUDINE THERAPY ON NEUROPSYCHOLOGICAL FUNCTIONING IN CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION SO JOURNAL OF PEDIATRICS LA English DT Article C1 NCI, PEDIAT BRANCH, BLDG 10, 13N240, BETHESDA, MD 20892 USA. NR 29 TC 99 Z9 102 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD DEC PY 1990 VL 117 IS 6 BP 980 EP 985 DI 10.1016/S0022-3476(05)80150-7 PG 6 WC Pediatrics SC Pediatrics GA EM116 UT WOS:A1990EM11600029 PM 2246704 ER PT J AU DOLL, BA TOWLE, HJ HOLLINGER, JO REDDI, AH MELLONIG, JT AF DOLL, BA TOWLE, HJ HOLLINGER, JO REDDI, AH MELLONIG, JT TI THE OSTEOGENIC POTENTIAL OF 2 COMPOSITE GRAFT SYSTEMS USING OSTEOGENIN SO JOURNAL OF PERIODONTOLOGY LA English DT Article C1 NORFOLK NAVAL STN,BRANCH DENT CLIN,DEPT PERIODONT,NORFOLK,VA. USA,INST DENT RES,PHYSIOL BRANCH,WASHINGTON,DC 20310. NIDR,BONE CELL BIOL SECT,BETHESDA,MD. UNIV TEXAS,SCH HLTH SCI,DEPT PERIODONT,SAN ANTONIO,TX 78285. RP DOLL, BA (reprint author), USN ACAD,DEPT PERIODONT,ANNAPOLIS,MD 21402, USA. NR 32 TC 43 Z9 44 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD DEC PY 1990 VL 61 IS 12 BP 745 EP 750 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EM128 UT WOS:A1990EM12800005 PM 1980137 ER PT J AU PRITCHARD, JB AF PRITCHARD, JB TI RAT RENAL CORTICAL SLICES DEMONSTRATE PARA-AMINOHIPPURATE GLUTARATE EXCHANGE AND SODIUM GLUTARATE COUPLED PARA-AMINOHIPPURATE TRANSPORT SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID BASOLATERAL MEMBRANE-VESICLES; DICARBOXYLIC-ACIDS; PROXIMAL CONVOLUTION; PAH TRANSPORT; KIDNEY SLICES; NA+; SECRETION; TUBULE AB In isolated basolateral membrane vesicles p-aminohippurate (PAH) transport may be coupled indirectly to the sodium gradient through PAH/glutarate [or alpha-ketoglutarate (alpha-KG)] exchange and Na/glutarate cotransport. In this study, rat renal cortical slices were used to examine indirect coupling of PAH transport to sodium in intact renal tissue. Like basolateral membrane vesicles, slices demonstrated avid uptake of 50-mu-M]C-14[glutarate. Steadystate tissue/medium ratios of 30 were achieved by 90 to 120 min. Uptake was inhibited markedly by lithium and fumarate. PAH also inhibited glutarate accumulation, but through acceleration of glutarate efflux, i.e., PAH/glutarate exchange, rather than direct inhibition of uptake. PAH-driven efflux of glutarate from slices was blocked by probenecid, which inhibits PAH/glutarate exchange in vesicles. Inasmuch as slices showed both Na/glutarate uptake and PAH/glutarate exchange, externally added glutarate should stimulate PAH uptake in slices. Indeed, in the presence of sodium, 50 mu-M external glutarate approximately doubled PAH accumulation by the slices. Stimulation by glutarate was abolished by either lithium or fumarate, or by elimination of sodium from the external buffer. The stimulatory effect was specific for glutarate of alpha-KG. Acetate, fumarate and succinate stimulated PAH uptake poorly, it at all. Neither fumarate nor lithium was able to eliminate concentrative PAH uptake completely, suggesting that a portion of PAH transport may occur without Na-dependent glutarate or alpha-KG recycling, i.e., that it may run directly off metabolic alpha-KG production or via a completely glutarate/alpha-KG independent mechanism. RP PRITCHARD, JB (reprint author), NIEHS,CELLULAR & MOLEC PHARMACOL LAB,COMPARAT MEMBRANE PHARMACOL SECT,RES TRIANGLE PK,NC 27709, USA. NR 29 TC 67 Z9 67 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1990 VL 255 IS 3 BP 969 EP 975 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP054 UT WOS:A1990EP05400007 PM 2262915 ER PT J AU GRIFFITHS, RR EVANS, SM HEISHMAN, SJ PRESTON, KL SANNERUD, CA WOLF, B WOODSON, PP AF GRIFFITHS, RR EVANS, SM HEISHMAN, SJ PRESTON, KL SANNERUD, CA WOLF, B WOODSON, PP TI LOW-DOSE CAFFEINE PHYSICAL-DEPENDENCE IN HUMANS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID PSYCHIATRIC-INPATIENTS; COFFEE; WITHDRAWAL; ANXIETY AB This study investigated the effects of terminating low dose levels of caffeine (100 mg/day) in 7 normal humans. Substitution of placebo capsules for caffeine capsules occurred under double-blind conditions while subjects rated various dimensions of their mood and behavior. In the first phase of the study, substitution of placebo for 12 consecutive days resulted in an orderly withdrawal syndrome in 4 subjects which peaked on days 1 or 2 and progressively decreased toward prewithdrawal levels over about 1 week. Data from the remaining three subjects provided no evidence of withdrawal. In the second phase of the study, the generality of the withdrawal effect was examined by repeatedly substituting placebo for 100 mg/day of caffeine for 1-day periods separated by an average of 9 days. Despite differences within and across subjects with respect to the presence, nature and magnitude of symptoms, each of the seven subjects demonstrated a statistically significant withdrawal effect. Although the phenomenon of caffeine withdrawal has been described previously, the present report documents that the incidence of caffeine withdrawal is higher (100% of subjects), the daily dose level at which withdrawal occurs is lower (roughly equivalent to the amount of caffeine in a single cup of strong brewed coffee or 3 cans of caffeinated soft drink) and the range of symptoms experienced is broader (including headache, fatigue and other dysphoric mood changes, muscle pain/stiffness, flu-like feelings, nausea/vomiting and craving for caffeine) than heretofore recognized. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205. NIDA,ADDICT RES CTR,BALTIMORE,MD. RP GRIFFITHS, RR (reprint author), JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,720 RUTLAND AVE,BALTIMORE,MD 21205, USA. RI Preston, Kenzie/J-5830-2013 OI Preston, Kenzie/0000-0003-0603-2479 FU NIDA NIH HHS [R01 DA03890] NR 28 TC 117 Z9 118 U1 1 U2 18 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1990 VL 255 IS 3 BP 1123 EP 1132 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP054 UT WOS:A1990EP05400030 PM 2262896 ER PT J AU FELDER, CC DIETER, P KINSELLA, J TAMURA, K KANTERMAN, RY AXELROD, J AF FELDER, CC DIETER, P KINSELLA, J TAMURA, K KANTERMAN, RY AXELROD, J TI A TRANSFECTED M5 MUSCARINIC ACETYLCHOLINE-RECEPTOR STIMULATES PHOSPHOLIPASE-A2 BY INDUCING BOTH CALCIUM INFLUX AND ACTIVATION OF PROTEIN-KINASE-C SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID ARACHIDONIC-ACID; INTRACELLULAR CA-2+; DIGLYCERIDE LIPASE; NA+/H+ EXCHANGE; HUMAN-PLATELETS; CELLS; RELEASE; RAT; MOBILIZATION; HYDROLYSIS AB Receptor-mediated arachidonic acid release and its relationship to phospholipase A2 and phospholipase C activation were investigated in Chinese hamster ovary cells transfected with and expressing the m5 muscarinic receptor. Carbachol, a muscarinic receptor agonist, stimulated the release of arachidonic acid and inositol phosphates with similar potencies. In addition, carbachol and the phorbol ester, phorbol-12-myristate, 13-acetate (PMA), stimulated protein kinase C(PKC) activity. PMA potentiated the carbachol-stimulated release of arachidonic acid, but had no effect on release of inositol phosphates. Long-term preincubation with PMA or carbachol inhibited PKC activity and prevented carbachol-stimulated release of arachidonic acid, but not inositol phosphates, suggesting that release of arachidonic acid, but not release of inositol phosphates, required activation of PKC. Carbachol stimulated the release of ]H-3[lysophosphatidylcholine from [H-3]choline prelabeled cells, suggesting that phospholipase A2 was involved in the release of arachidonic acid. The role of calcium in carbachol-stimulated release of arachidonic acid was also investigated. Carbachol stimulated a transient followed by a sustained increase in intracellular calcium. In the absence of extracellular calcium, the transient rise in intracellular calcium was maintained but the sustained increase in intracellular calcium and the release of arachidonic acid were abolished. Carbachol stimulated a sustained influx of CA-45++. We conclude that the combined effect of PKC activation and sustained elevation of intracellular calcium, from an extracellular source, is essential for m5 muscarinic receptor activation of phospholipase A2. C1 UNIV FREIBURG,INST BIOCHEM,W-7800 FREIBURG,GERMANY. NIA,BIOL CHEM LAB,BALTIMORE,MD 21224. NIH,RES SCHOLARS PROGRAM,HOWARD HUGHES MED INST,BETHESDA,MD 20892. RP FELDER, CC (reprint author), NIMH,CELL BIOL LAB,PHARMACOL SECT,BLDG 36,RM 3A-15,BETHESDA,MD 20892, USA. NR 39 TC 68 Z9 68 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1990 VL 255 IS 3 BP 1140 EP 1147 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP054 UT WOS:A1990EP05400032 PM 2124620 ER PT J AU EVANS, SM FUNDERBURK, FR GRIFFITHS, RR AF EVANS, SM FUNDERBURK, FR GRIFFITHS, RR TI ZOLPIDEM AND TRIAZOLAM IN HUMANS - BEHAVIORAL AND SUBJECTIVE EFFECTS AND ABUSE LIABILITY SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID DISCRIMINATIVE STIMULUS PROPERTIES; BENZODIAZEPINE RECEPTOR LIGANDS; PREFERENTIAL AFFINITY; IMIDAZOPYRIDINE; DIAZEPAM; MEMORY; RATS; CONSUMPTION; PERFORMANCE; HYPNOTICS AB Zolpidem, which is currently marketed in Europe as a hypnotic, is a short-duration imidazopyridine whose actions are mediated at the gamma-aminobutyric acid benzodiazepine receptor complex. However, zolpidem produces a variety of biochemical differences from classic benzodiazepine agonist including showing selectivity for the central BZ1 (omega-1) receptor subtype as well as showing a different pattern of distribution of binding sites. This study compared zolpidem to the benzodiazepine hypnotic triazolam in 15 healthy male volunteers with histories of sedative drug abuse. Placebo, zolpidem (15, 30 and 45 mg) and triazolam (0.25, 0.5 and 0.75 mg) were administered p.o. in a mixed sequence in a double-blind, cross-over design. The onset time with zolpidem was faster than with triazolam, with peak effects of both drugs occurring at 1 to 2 hr after administration. Both zolpidem and triazolam produced dose-related decrements in performance on various performance tasks including circular lights, reaction time, balance, number recall and the digit symbol substitution test. Both drugs also produced similar dose-related changes on various observer rating including overall strength of drug effect. Triazolam, but not zolpidem, increased subject- and observer- rated sleepiness and produced greater impairment on a picture memory task. Zolpidem, but not triazolam, produced increases in subject rating of various somatic symptoms (e.g., dizzy, anxious and queasy) and there were 9 days on which subjects vomited after zolpidem, but none after triazolam. Although the highest dose of both drugs was identified by subjects as being active, the highest dose of triazolam was identified as being barbiturate, benzodiazepine or alcohol, almost twice as often as the highest dose of zolpidem. Overall, this study shows that although zolpidem produces many effects in common with triazolam, it also has a unique profile of effects distinguishable from classic benzodiazepine agonists. The mechanism(s) underlying these differences is unclear, but may be related to the atypical biochemical profile of zolpidem. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,720 RUTLAND AVE,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205. NIDA,ADDICT RES CTR,BALTIMORE,MD. ANTECH INC,BALTIMORE,MD. FU NIDA NIH HHS [DA-03889] NR 43 TC 157 Z9 157 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1990 VL 255 IS 3 BP 1246 EP 1255 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP054 UT WOS:A1990EP05400047 PM 2262904 ER PT J AU SOERGEL, DG GUSOVSKY, F YASUMOTO, T DALY, JW AF SOERGEL, DG GUSOVSKY, F YASUMOTO, T DALY, JW TI STIMULATORY EFFECTS OF MAITOTOXIN ON INSULIN RELEASE IN INSULINOMA HIT CELLS - ROLE OF CALCIUM-UPTAKE AND PHOSPHOINOSITIDE BREAKDOWN SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID RAT PHEOCHROMOCYTOMA CELLS; CYTOSOLIC FREE CA-2+; PANCREATIC-ISLETS; INOSITOL PHOSPHATES; PHOSPHOLIPASE-C; SECRETION; 1,4,5-TRISPHOSPHATE; CARBAMYLCHOLINE; HYDROLYSIS; CHANNELS AB In hamster insulinoma (HIT) cells, maitotoxin (MTX) induces a time-dependent and concentration-dependent release of insulin that requires the presence of extracellular calcium. The response is nearly completely blocked by cinnarizine and cadmium, but is not inhibited by the L-type calcium channel blocker nifedipine or by manganese. MTX induces Ca-45+ uptake in these cells in a dose-dependent mode, and the uptake is blocked with cinnarizine, nifedipine and cadmium, and is partially inhibited by manganese. MTX induces phosphoinositide breakdown in HIT cells, and the response is partially blocked by cadmium, but is not affected by nifedipine, cinnarizine or manganese. High concentrations of potassium ions also induce insulin release and calcium uptake in HIT cells. Both effects of potassium are blocked partially by nifedipine, cadmium and cinnarizine. High concentrations of potassium do not induce phosphoinositide breakdown in HIT cells. The results suggest that MTX-elicited release of insulin is attained by two mechanisms: 1) a nifedipine-sensitive action, which results from MTX-induced activation of L-type calcium channels, which can be mimicked with high potassium concentrations; and 2) a nifedipine-insensitive action, which may be initiated by the activation of phosphoinositide breakdown by MTX. Such an activation of phospholipase C would result in the formation of 1,4,5-inositol trisphosphate, a release of intracellular calcium and then release of insulin to the extracellular space. Cinnarizine is proposed to block both MTX-elicited mechanisms, the first by blockade of calcium channels and the second by blocking 1,4,5-inositol trisphosphate-induced release of internal calcium. Either mechanism alone appears capable of eliciting release of insulin. C1 TOHOKU UNIV,FAC AGR,SENDAI,MIYAGI 980,JAPAN. RP SOERGEL, DG (reprint author), NIDDKD,BIOORGAN CHEM LAB,BLDG 8,ROOM 1A-15,BETHESDA,MD 20892, USA. NR 23 TC 24 Z9 24 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1990 VL 255 IS 3 BP 1360 EP 1365 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP054 UT WOS:A1990EP05400062 PM 2175805 ER PT J AU DRISCOLL, WS NOWJACKRAYMER, R HEIFETZ, SB LI, SH SELWITZ, RH AF DRISCOLL, WS NOWJACKRAYMER, R HEIFETZ, SB LI, SH SELWITZ, RH TI EVALUATION OF THE COMPARATIVE EFFECTIVENESS OF FLUORIDE MOUTHRINSING, FLUORIDE TABLETS, AND BOTH PROCEDURES IN COMBINATION - INTERIM FINDINGS AFTER 5 YEARS SO JOURNAL OF PUBLIC HEALTH DENTISTRY LA English DT Article RP DRISCOLL, WS (reprint author), NIDR,EPIDEMIOL & ORAL DIS PREVENT PROGRAM,DIS PREVENT & HLTH PROMOT BRANCH,BETHESDA,MD 20892, USA. NR 15 TC 9 Z9 9 U1 0 U2 0 PU AAPHD NATIONAL OFFICE PI RICHMOND PA J PUBLIC HEALTH DENT 10619 JOUSTING LANE, RICHMOND, VA 23235 SN 0022-4006 J9 J PUBLIC HEALTH DENT JI J. Public Health Dent. PD WIN PY 1990 VL 50 IS 1 BP 13 EP 17 DI 10.1111/j.1752-7325.1990.tb03550.x PG 5 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA CH998 UT WOS:A1990CH99800003 PM 2295997 ER PT J AU BAXTER, DL JOYCE, AP FELDMAN, BD LYNCH, JW AF BAXTER, DL JOYCE, AP FELDMAN, BD LYNCH, JW TI CISPLATIN CHEMOTHERAPY FOR BASAL-CELL CARCINOMA - THE NEED FOR POSTTREATMENT BIOPSY - REPORT OF A CASE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note C1 NCI, MED ONCOL BRANCH, BETHESDA, MD 20892 USA. RP BAXTER, DL (reprint author), NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. NR 9 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD DEC PY 1990 VL 23 IS 6 BP 1167 EP 1168 DI 10.1016/S0190-9622(08)80919-X PN 1 PG 2 WC Dermatology SC Dermatology GA EM964 UT WOS:A1990EM96400022 PM 2273122 ER PT J AU COOPER, KD VOORHEES, JJ FISHER, GJ CHAN, LS GUPTA, AK BAADSGAARD, O AF COOPER, KD VOORHEES, JJ FISHER, GJ CHAN, LS GUPTA, AK BAADSGAARD, O TI EFFECTS OF CYCLOSPORINE ON IMMUNOLOGICAL MECHANISMS IN PSORIASIS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article; Proceedings Paper CT SYMP ON CYCLOSPORINE IN DERMATOLOGY CY JAN 27-28, 1990 CL ORLANDO, FL C1 UNIV COPENHAGEN,DEPT DERMATOL,DK-2900 HELLERUP,DENMARK. NCI,BETHESDA,MD 20892. RP COOPER, KD (reprint author), UNIV MICHIGAN,MED CTR,DEPT DERMATOL,IMMUNODERMATOL UNIT,R5548 KRESGE I-0530,1301 CATHERINE ST,ANN ARBOR,MI 48109, USA. NR 119 TC 26 Z9 26 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD DEC PY 1990 VL 23 IS 6 SU S BP 1318 EP 1328 DI 10.1016/0190-9622(90)70360-T PN 2 PG 11 WC Dermatology SC Dermatology GA EN064 UT WOS:A1990EN06400012 PM 2277141 ER PT J AU HASEMAN, JK ZEIGER, E SHELBY, MD MARGOLIN, BH TENNANT, RW AF HASEMAN, JK ZEIGER, E SHELBY, MD MARGOLIN, BH TENNANT, RW TI PREDICTING RODENT CARCINOGENICITY FROM 4 INVITRO GENETIC TOXICITY ASSAYS - AN EVALUATION OF 114 CHEMICALS STUDIED BY THE NATIONAL TOXICOLOGY PROGRAM SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION LA English DT Article C1 NIEHS,EXPTL TOXICOL BRANCH,ENVIRONM MUTAGENESIS GRP,RES TRIANGLE PK,NC 27709. NIEHS,EXPTL CARCINOGENESIS & MUTAGENESIS BRANCH,RES TRIANGLE PK,NC 27709. UNIV N CAROLINA,DEPT BIOSTAT,CHAPEL HILL,NC 27599. RP HASEMAN, JK (reprint author), NIEHS,DIV BIOMETRY & RISK ASSESSMENT,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 17 TC 18 Z9 18 U1 1 U2 1 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0162-1459 J9 J AM STAT ASSOC JI J. Am. Stat. Assoc. PD DEC PY 1990 VL 85 IS 412 BP 964 EP 971 PG 8 WC Statistics & Probability SC Mathematics GA EN054 UT WOS:A1990EN05400006 ER PT J AU HUMPHREY, EW SMART, CR WINCHESTER, DP STEELE, GD YARBRO, JW CHU, KC TRIOLO, HH AF HUMPHREY, EW SMART, CR WINCHESTER, DP STEELE, GD YARBRO, JW CHU, KC TRIOLO, HH TI NATIONAL SURVEY OF THE PATTERN OF CARE FOR CARCINOMA OF THE LUNG SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY LA English DT Article C1 NEW ENGLAND DEACONESS HOSP, DEPT SURG, BOSTON, MA 02215 USA. UNIV MINNESOTA, DEPT SURG, MINNEAPOLIS, MN 55455 USA. NCI, EARLY DETECT BRANCH, BETHESDA, MD 20892 USA. UNIV MISSOURI, DEPT MED, COLUMBIA, MO 65201 USA. INFORMAT MANAGEMENT SERV INC, SILVER SPRING, MD USA. RP AMER COLL SURGEONS, DEPT CANC, COMMISS CANC, 55 E ERIE ST, CHICAGO, IL 60611 USA. NR 11 TC 69 Z9 70 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5223 EI 1097-685X J9 J THORAC CARDIOV SUR JI J. Thorac. Cardiovasc. Surg. PD DEC PY 1990 VL 100 IS 6 BP 837 EP 843 PG 7 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA EM117 UT WOS:A1990EM11700004 PM 2246906 ER PT J AU ROSSI, F KOLOBOW, T FOTI, G BORELLI, M MANDAVA, S AF ROSSI, F KOLOBOW, T FOTI, G BORELLI, M MANDAVA, S TI LONG-TERM CARDIOPULMONARY BYPASS BY PERIPHERAL CANNULATION IN A MODEL OF TOTAL HEART-FAILURE - THE DECOMPRESSION OF THE LEFT HEART THROUGH A PERCUTANEOUS HELICAL SPRING POSITIONED WITHIN THE LUMEN OF THE TRICUSPID AND PULMONARY-ARTERY VALVES SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY LA English DT Article C1 NHLBI,PULM & CARDIAC ASSIST DEVICES SECT,BLDG 10,ROOM 5D18,BETHESDA,MD 20892. RI Foti, Giuseppe/K-8627-2016 NR 18 TC 14 Z9 14 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-5223 J9 J THORAC CARDIOV SUR JI J. Thorac. Cardiovasc. Surg. PD DEC PY 1990 VL 100 IS 6 BP 914 EP 920 PG 7 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA EM117 UT WOS:A1990EM11700015 PM 2246914 ER PT J AU KIRSCHSTEIN, RL AF KIRSCHSTEIN, RL TI PROCEEDINGS OF THE NIH CONFERENCE - ADVANCES IN UNDERSTANDING TRAUMA AND BURN INJURY WASHINGTON, DC 21-23 JUNE 1990 - PREFACE SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material RP KIRSCHSTEIN, RL (reprint author), NATL INST GEN MED SCI,WESTWOOD BLDG,ROOM 926,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 1990 VL 30 IS 12 SU S BP R3 EP R3 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA EQ497 UT WOS:A1990EQ49700001 ER PT J AU WHETTER, L ARCHAMBAULT, D PERRY, S GAZIT, A COGGINS, L YANIV, A CLABOUGH, D DAHLBERG, J FULLER, F TRONICK, S AF WHETTER, L ARCHAMBAULT, D PERRY, S GAZIT, A COGGINS, L YANIV, A CLABOUGH, D DAHLBERG, J FULLER, F TRONICK, S TI EQUINE INFECTIOUS-ANEMIA VIRUS DERIVED FROM A MOLECULAR CLONE PERSISTENTLY INFECTS HORSES SO JOURNAL OF VIROLOGY LA English DT Article C1 N CAROLINA STATE UNIV,SCH VET MED,DEPT MICROBIOL PATHOL & PARASITOL,RALEIGH,NC 27606. NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892. TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL. FU NIAID NIH HHS [R01-AI24904] NR 38 TC 24 Z9 26 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 5750 EP 5756 PG 7 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200007 PM 2173767 ER PT J AU HOLLAND, SM AHMAD, N MAITRA, RK WINGFIELD, P VENKATESAN, S AF HOLLAND, SM AHMAD, N MAITRA, RK WINGFIELD, P VENKATESAN, S TI HUMAN-IMMUNODEFICIENCY-VIRUS REV PROTEIN RECOGNIZES A TARGET SEQUENCE IN REV-RESPONSIVE ELEMENT RNA WITHIN THE CONTEXT OF RNA SECONDARY STRUCTURE SO JOURNAL OF VIROLOGY LA English DT Article C1 NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892. NIH,PROT EXPRESS LAB,BETHESDA,MD 20892. NR 45 TC 99 Z9 100 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 5966 EP 5975 PG 10 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200031 PM 2243382 ER PT J AU GOTTLIEB, J MARCY, AI COEN, DM CHALLBERG, MD AF GOTTLIEB, J MARCY, AI COEN, DM CHALLBERG, MD TI THE HERPES-SIMPLEX VIRUS TYPE-1 UL42 GENE-PRODUCT - A SUBUNIT OF DNA-POLYMERASE THAT FUNCTIONS TO INCREASE PROCESSIVITY SO JOURNAL OF VIROLOGY LA English DT Article C1 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892. HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. FU NIAID NIH HHS [R01 AI1838] NR 55 TC 177 Z9 178 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 5976 EP 5987 PG 12 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200032 PM 2173776 ER PT J AU SOLOMIN, L FELBER, BK PAVLAKIS, GN AF SOLOMIN, L FELBER, BK PAVLAKIS, GN TI DIFFERENT SITES OF INTERACTION FOR REV, TEV, AND REX PROTEINS WITHIN THE REV-RESPONSIVE ELEMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO JOURNAL OF VIROLOGY LA English DT Article C1 NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,FREDERICK,MD 21701. FU NCI NIH HHS [N01-CO-74101] NR 44 TC 62 Z9 62 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 6010 EP 6017 PG 8 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200035 PM 2243384 ER PT J AU EVANS, LH MORRISON, RP MALIK, FG PORTIS, J BRITT, WJ AF EVANS, LH MORRISON, RP MALIK, FG PORTIS, J BRITT, WJ TI A NEUTRALIZABLE EPITOPE COMMON TO THE ENVELOPE GLYCOPROTEINS OF ECOTROPIC, POLYTROPIC, XENOTROPIC, AND AMPHOTROPIC MURINE LEUKEMIA VIRUSES SO JOURNAL OF VIROLOGY LA English DT Article C1 NIAID,ROCKY MT LABS,INTRACELLULAR PARASITES LAB,HAMILTON,MT 59840. UNIV ALABAMA,DEPT PEDIAT,UNIV STN,BIRMINGHAM,AL 35294. RP EVANS, LH (reprint author), NIAID,ROCKY MT LABS,PERSISTENT VIRAL DIS LAB,HAMILTON,MT 59840, USA. NR 57 TC 142 Z9 142 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 6176 EP 6183 PG 8 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200053 PM 1700832 ER PT J AU ROFFMAN, E ALBERT, JP GOFF, JP FRENKEL, N AF ROFFMAN, E ALBERT, JP GOFF, JP FRENKEL, N TI PUTATIVE SITE FOR THE ACQUISITION OF HUMAN HERPESVIRUS-6 VIRION TEGUMENT SO JOURNAL OF VIROLOGY LA English DT Note C1 NIAID,VIRAL DIS LAB,12441 PARKLAWN DR,ROCKVILLE,MD 20852. GEORGETOWN UNIV,MED CTR,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852. NR 22 TC 49 Z9 49 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 6308 EP 6313 PG 6 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200072 PM 2173796 ER PT J AU LUSSO, P LORI, F GALLO, RC AF LUSSO, P LORI, F GALLO, RC TI CD4-INDEPENDENT INFECTION BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AFTER PHENOTYPIC MIXING WITH HUMAN T-CELL LEUKEMIA VIRUSES SO JOURNAL OF VIROLOGY LA English DT Note RP LUSSO, P (reprint author), NCI,TUMOR CELL BIOL LAB,BLDG 37,ROOM 6A09,BETHESDA,MD 20892, USA. NR 37 TC 52 Z9 52 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 6341 EP 6344 PG 4 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200078 PM 2243398 ER PT J AU MACKAY, K KONDAIAH, P DANIELPOUR, D AUSTIN, HA BROWN, PD AF MACKAY, K KONDAIAH, P DANIELPOUR, D AUSTIN, HA BROWN, PD TI EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA-1 AND BETA-2 IN RAT GLOMERULI SO KIDNEY INTERNATIONAL LA English DT Article ID CELLS; RECEPTORS; SEQUENCE; TISSUES; ADULT AB The transforming growth factors-beta are potent modulators of cell growth and extracellular matrix metabolism in most types of cultured cells. The distribution and functions of TGF-beta in vivo are less well known. We utilized several different techniques including northern blots, a CCl-64 cell growth inhibition assay, and sandwich enzyme-linked immunosorbent assays (SELISA) to examine the expression of TGF-beta-1 and TGF-beta-2 in rat glomeruli. High levels of TGF-beta-1 mRNA and protein were found in glomeruli (56 +/- 22 ng TGF-beta-1/g tissue). These levels were several-fold higher than those present in whole kidney (10 +/- 5 ng/g). TGF-beta-2 mRNA was present in glomeruli but was not detected in whole kidney. TGF-beta-2 concentrations by SELISA were 19 +/- 8 ng TGF-beta-2/g in glomeruli and less than 5 ng/g in whole kidney. Since TGF-beta has such marked effects on cell growth, we also examined whether alterations in TGF-beta expression were associated with the renal hypertrophy which follows unilateral nephrectomy. Expression of TGF-beta-1 mRNA decreased in glomeruli following nephrectomy. However, this was not associated with a significant fall in glomerular TGF-beta-1 protein concentration. Whole kidney levels of TGF-beta-1 and its mRNA were unchanged following nephrectomy. Similar results were obtained for TGF-beta-2. Our data document the presence of high concentrations of TGF-beta-1 and beta-2 and their corresponding mRNAs in normal rat glomeruli. These results suggest that TGF-beta may play important regulatory roles in the normal glomerulus. C1 NCI, CHEMOPREVENT LAB, BETHESDA, MD 20892 USA. RP MACKAY, K (reprint author), NIDDKD, METAB DIS BRANCH,KIDNEY DIS SECT,BLDG 10,RM 3N106, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA. FU NIDDK NIH HHS [DK07843 03] NR 23 TC 94 Z9 97 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD DEC PY 1990 VL 38 IS 6 BP 1095 EP 1100 DI 10.1038/ki.1990.318 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA FA892 UT WOS:A1990FA89200011 PM 2074653 ER PT J AU LAGRENADE, L HANCHARD, B FLETCHER, V CRANSTON, B BLATTNER, W AF LAGRENADE, L HANCHARD, B FLETCHER, V CRANSTON, B BLATTNER, W TI INFECTIVE DERMATITIS OF JAMAICAN CHILDREN - A MARKER FOR HTLV-I INFECTION SO LANCET LA English DT Article C1 NCI,EXECUT PLAZA N,ROOM 434,BETHESDA,MD 20892. UNIV W INDIES,DEPT MED,KINGSTON 7,JAMAICA. UNIV W INDIES,DEPT PATHOL,KINGSTON 7,JAMAICA. FU NCI NIH HHS [N01-CP3-1006-00] NR 23 TC 291 Z9 300 U1 1 U2 2 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD DEC 1 PY 1990 VL 336 IS 8727 BP 1345 EP 1347 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA EL365 UT WOS:A1990EL36500005 PM 1978165 ER PT J AU VANKRIEKEN, JHJM MCKEITHAN, TW RAGHOEBIER, S MEDEIROS, LJ KLUIN, PM RAFFELD, M AF VANKRIEKEN, JHJM MCKEITHAN, TW RAGHOEBIER, S MEDEIROS, LJ KLUIN, PM RAFFELD, M TI CHROMOSOMAL TRANSLOCATION T(14-19) AS INDICATED BY BCL-3 REARRANGEMENT IS A RARE PHENOMENON IN NON-HODGKINS-LYMPHOMA AND CHRONIC LYMPHOCYTIC-LEUKEMIA - A MOLECULAR GENETIC-ANALYSIS OF 176 CASES SO LEUKEMIA LA English DT Article ID HEAVY-CHAIN LOCUS; C-MYC ONCOGENE; BURKITT-LYMPHOMA; ACTIVATION AB Using a probe for the newly described bcl-3 gene near the breakpoint of the t(14;19), 176 cases of non-Hodgkin lymphoma and B cell chronic lymphocytic leukemia were analyzed. Rearrangement of the bcl-3 gene was found in only one case, a follicular lymphoma involving the salivary gland that had progressed to a diffuse large cell lymphoma. We conclude that rearrangement of the bcl-3 gene as detected by our method occurs rarely in mature B or T cell neoplasms. C1 NCI,DEPT PATHOL,BETHESDA,MD 20892. UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637. RP VANKRIEKEN, JHJM (reprint author), UNIV HOSP LEIDEN,DEPT PATHOL,POB 9603,2300 RC LEIDEN,NETHERLANDS. RI van Krieken, Joannes/D-4138-2009 OI van Krieken, Joannes/0000-0001-6544-1040 NR 15 TC 24 Z9 24 U1 0 U2 1 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0887-6924 J9 LEUKEMIA JI Leukemia PD DEC PY 1990 VL 4 IS 12 BP 811 EP 812 PG 2 WC Oncology; Hematology SC Oncology; Hematology GA EQ200 UT WOS:A1990EQ20000004 PM 2243504 ER PT J AU HIROSE, K ZACHARIAE, COC OPPENHEIM, JJ MATSUSHIMA, K AF HIROSE, K ZACHARIAE, COC OPPENHEIM, JJ MATSUSHIMA, K TI INDUCTION OF GENE-EXPRESSION AND PRODUCTION OF IMMUNOMODULATING CYTOKINES BY PSK IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS SO LYMPHOKINE RESEARCH LA English DT Article C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21702. NR 51 TC 79 Z9 79 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 475 EP 483 PG 9 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500003 PM 2090874 ER PT J AU FAUCI, AS AF FAUCI, AS TI CYTOKINE REGULATION OF HIV EXPRESSION SO LYMPHOKINE RESEARCH LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL LYMPHOKINE WORKSHOP - LYMPHOKINES 1990 : CELL BIOLOGY, PHYSIOLOGY, THERAPY CY OCT 01-05, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS, M D ANDERSON CANC CTR, USA, MED RES & DEV COMMAND, USN, NAVAL RES, SCHERING, SCHERING PLOUGH RES, GENZYME, ROUSELL UCLAF, INST SCI ROUSSEL, BURROUGHS WELLCOME, SYNTEX RES, HOFFMANN LA ROCHE RP FAUCI, AS (reprint author), NIAID,IMMUNOREGULAT LAB,9000 ROCKVILLE PIKE,BLDG 31,ROOM 7A-03,BETHESDA,MD 20892, USA. NR 16 TC 21 Z9 21 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 527 EP 531 PG 5 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500008 PM 2090879 ER PT J AU MICHIEL, D GARCIA, G EVANS, G LINNEKIN, D FARRAR, WL AF MICHIEL, D GARCIA, G EVANS, G LINNEKIN, D FARRAR, WL TI IDENTIFICATION OF A TYROSINE KINASE-ACTIVITY ASSOCIATED WITH THE IL-2 RECEPTOR COMPLEX SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,BRMP,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701. PROGRAM RESOURCES INC,FREDERICK CANC RES & DEV CTR,BIOL CARCINOGENESIS DEV PROGRAM,FREDERICK,MD 21701. NR 0 TC 4 Z9 4 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 550 EP 550 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500015 ER PT J AU SCHWABE, M BRINI, AT PRINCLER, GL KUNG, H AF SCHWABE, M BRINI, AT PRINCLER, GL KUNG, H TI THE COMPLEX STRUCTURE OF THE IL-6 RECEPTOR (IL-6 R) - IDENTIFICATION OF 3 DISTINCT LIGAND-BINDING PROTEINS SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,BRMP,BIOCHEM PHYSIOL LAB,FREDERICK,MD 21702. NIAID,MOLEC ALLERGY & IMMUNOL SECT,ROCKVILLE,MD 20852. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 550 EP 550 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500014 ER PT J AU TAN, TH AF TAN, TH TI CLONING OF 2 DNA-BINDING PROTEINS THAT INTERACT WITH THE T-CELL REGULATORY ELEMENT OF THE IL-2 RECEPTOR ALPHA-CHAIN GENE SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES 1 DEV CTR,PROGRAM RESOURCES INC,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 556 EP 556 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500020 ER PT J AU SMITH, J URBA, W STEIS, R JANIK, J FENTON, B SHARFMAN, W CONLON, K SZNOL, M CREEKMORE, S WELLS, N ELWOOD, L KELLER, J HESTDAL, K EWEL, C ROSSIO, J KOPP, W SHIMUZU, M OPPENHEIM, J LONGO, D AF SMITH, J URBA, W STEIS, R JANIK, J FENTON, B SHARFMAN, W CONLON, K SZNOL, M CREEKMORE, S WELLS, N ELWOOD, L KELLER, J HESTDAL, K EWEL, C ROSSIO, J KOPP, W SHIMUZU, M OPPENHEIM, J LONGO, D TI A PHASE-I TRIAL OF INTERLEUKIN-1-ALPHA (IL-1-ALPHA) ALONE AND IN COMBINATION WITH INDOMETHACIN SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCE INC,FREDERICK,MD 21702. DCT,BRMP,FREDERICK,MD 21702. FREDERICK MEM HOSP,FREDERICK,MD 21702. DAINIPPON PHARMACEUT CO LTD,OSAKA,JAPAN. NR 0 TC 7 Z9 7 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 568 EP 568 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500033 ER PT J AU PRINCLER, GL BRINI, AT KUNG, H SCHWABE, M AF PRINCLER, GL BRINI, AT KUNG, H SCHWABE, M TI IFN-ALPHA DOWN-REGULATES THE IL-6 RECEPTOR (IL-6-R) BY INDUCTION OF ENDOGENEOUS IL-6 SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,BRMP,BIOCHEM PHYSIOL LAB,FREDERICK,MD 21702. NIAID,MOLEC ALLERGY & IMMUNOL SECT,ROCKVILLE,MD 20852. NR 0 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 570 EP 570 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500038 ER PT J AU LINNEKIN, D EVANS, G GARCIA, G MICHIEL, D FARRAR, W AF LINNEKIN, D EVANS, G GARCIA, G MICHIEL, D FARRAR, W TI IL-2, IL-3 AND GM-CSF SIGNAL TRANSDUCTION PATHWAYS CONVERGE ON SIMILAR PROTEIN-KINASES WHICH HAVE CONSERVED AND LINEAGE SPECIFIC SUBSTRATES SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,MOLEC IMMUNOREGULAT LAB,BETHESDA,MD 20710. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 576 EP 576 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500053 ER PT J AU ORTALDO, J MASON, A OSHEA, J SMYTH, M FALK, L RUSCETTI, F AF ORTALDO, J MASON, A OSHEA, J SMYTH, M FALK, L RUSCETTI, F TI TGF-BETA REGULATION OF CD3- LYMPHOCYTE FUNCTIONS - MODULATION OF IL2R-BETA [P75] SIGNALING SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BRMP,LEI & LMI,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 576 EP 576 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500054 ER PT J AU EADER, L FUTAMI, H KOMSCHLIES, K YOUNG, H BAGULEY, B WILTROUT, R AF EADER, L FUTAMI, H KOMSCHLIES, K YOUNG, H BAGULEY, B WILTROUT, R TI THE ABILITY OF FLAVONE ACETIC-ACID AND ITS ANALOGS TO INDUCE EXPRESSION OF CYTOKINES BY LYMPHOID-CELLS SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,PRI,BCPD,FREDERICK,MD 21701. NCI,FREDERICK CANC RES FACIL,BRMP,FREDERICK,MD 21701. UNIV AUCKLAND,SCH MED,AUCKLAND,NEW ZEALAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 581 EP 581 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500071 ER PT J AU BARILLARI, G BUONAGURO, L GALLO, RC ENSOLI, B AF BARILLARI, G BUONAGURO, L GALLO, RC ENSOLI, B TI ACTIVATED PERIPHERAL-BLOOD LYMPHOCYTES PRODUCE FACTORS PROMOTING THE GROWTH OF SPINDLE CELLS DERIVED FROM AIDS-ASSOCIATED KAPOSIS-SARCOMA SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. RI Ensoli, Barbara/J-9169-2016 OI Ensoli, Barbara/0000-0002-0545-8737 NR 1 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 582 EP 582 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500073 ER PT J AU MUKAIDA, N MAHE, Y MATSUSHIMA, K AF MUKAIDA, N MAHE, Y MATSUSHIMA, K TI ANALYSIS OF THE REGULATION OF INTERLEUKIN-8 (IL-8) GENE-EXPRESSION BY PROINFLAMMATORY CYTOKINES SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BRMP,FREDERICK,MD 21701. RI Mukaida, Naofumi/D-7623-2011 OI Mukaida, Naofumi/0000-0002-4193-1851 NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 582 EP 582 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500075 ER PT J AU KOBAYASHI, Y YAMAMOTO, K SAIDO, T KAWASAKI, H OPPENHEIM, JJ MATSUSHIMA, K AF KOBAYASHI, Y YAMAMOTO, K SAIDO, T KAWASAKI, H OPPENHEIM, JJ MATSUSHIMA, K TI MODEL FOR CALCIUM-MEDIATED PROCESSING AND RELEASE OF HUMAN PRE IL-1-ALPHA SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 TOHO UNIV,FAC SCI,FUNABASHI,CHIBA 274,JAPAN. UNIV TOKYO,FAC PHARMACEUT SCI,TOKYO 113,JAPAN. TOKYO METROPOLITAN INST MED SCI,DEPT MOLEC BIOL,TOKYO 113,JAPAN. NCI,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701. RI Kawasaki, Hiroshi/C-3048-2011 OI Kawasaki, Hiroshi/0000-0002-2517-159X NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 590 EP 590 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500103 ER PT J AU RUHL, S SCHWABE, M PLUZNIK, DH AF RUHL, S SCHWABE, M PLUZNIK, DH TI INTERLEUKIN-1 AUGMENTS THE EXPRESSION OF INTERLEUKIN-2 RECEPTORS ON DIFFERENTIATING MACROPHAGES SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BRMP,BIOCHEM PHYSIOL LAB,FREDERICK,MD 21701. US FDA,CBER,DIV CYTOKINE,BIOL,BETHESDA,MD 20014. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 591 EP 591 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500106 ER PT J AU MUEGGE, K MUSSO, T VILA, M DURUM, SK AF MUEGGE, K MUSSO, T VILA, M DURUM, SK TI C-JUN INDUCTION BY INTERLEUKIN-1 SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,REPROD MED & PHYSIOL BRANCH,MOLEC IMMUNOL LAB,FREDERICK,MD 21701. NCI,PHYSIOL RES INST,BCDP,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 595 EP 595 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500124 ER PT J AU PACIOTTI, GF BARON, DA LICINIO, J ALTEMUS, M WONG, M TAMARKIN, L AF PACIOTTI, GF BARON, DA LICINIO, J ALTEMUS, M WONG, M TAMARKIN, L TI DETERMINATION OF THE 24-HOUR PROFILES OF CIRCULATING IL-1-ALPHA AND IL-2 LEVELS IN NORMALS SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 ASSAY RES INC,COLLEGE PK,MD 20742. UNIV MARYLAND,COLLEGE PK,MD 20742. NIMH,BETHESDA,MD 20892. RI Licinio, Julio/L-4244-2013 OI Licinio, Julio/0000-0001-6905-5884 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 595 EP 595 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500123 ER PT J AU CLOUSE, KA PYLE, SW POTHEN, S COSENTINO, LM WEIH, KA PEARSON, GR AF CLOUSE, KA PYLE, SW POTHEN, S COSENTINO, LM WEIH, KA PEARSON, GR TI MONOKINES CAPABLE OF REGULATING HUMAN-IMMUNODEFICIENCY-VIRUS EXPRESSION SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. NCI,REPROD MED & PHYSIOL BRANCH,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 596 EP 596 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500129 ER PT J AU COX, GW MATHIESON, BJ VARESIO, L AF COX, GW MATHIESON, BJ VARESIO, L TI CHARACTERIZATION OF INTERLEUKIN-2 RECEPTOR EXPRESSION AND FUNCTION ON MURINE MACROPHAGES SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NIAID,DIV AIDS,BETHESDA,MD 20892. NCI,FREDERICK CANC RES FACIL,BRMP,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701. RI varesio, luigi/J-8261-2016 OI varesio, luigi/0000-0001-5659-2218 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 605 EP 605 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500161 ER PT J AU NETA, R CHIZZONITE, R SCHREIBER, RD OPPENHEIM, JJ PILCHER, M AF NETA, R CHIZZONITE, R SCHREIBER, RD OPPENHEIM, JJ PILCHER, M TI INTERACTION OF CYTOKINES IN MEDIATING THE NATURAL AND IMMUNOMODULATOR (LPS) INDUCED RADIORESISTANCE SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 ARMED FORCES RADIOBIOL RES INST,BETHESDA,MD 20814. HOFFMANN LA ROCHE INC,NUTLEY,NJ 07110. WASHINGTON UNIV,ST LOUIS,MO 63130. NCI,FREDERICK,MD 21701. RI Schreiber, Robert/A-1276-2013 OI Schreiber, Robert/0000-0001-6311-0432 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 611 EP 611 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500183 ER PT J AU ALLEN, JB BRANDES, ME COSTA, GL OGAWA, Y WAHL, SM AF ALLEN, JB BRANDES, ME COSTA, GL OGAWA, Y WAHL, SM TI TRANSFORMING GROWTH-FACTOR-BETA SUPPRESSES STREPTOCOCCAL CELL WALL-INDUCED ARTHRITIS IN RATS SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. COLLAGEN CORP,PALO ALTO,CA 94303. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 613 EP 613 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500190 ER PT J AU KELLER, JR JACOBSEN, SEW DUBOIS, C RUSCETTI, FW AF KELLER, JR JACOBSEN, SEW DUBOIS, C RUSCETTI, FW TI TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) REGULATES COLONY STIMULATING STIMULATING FACTOR (CSF) RECEPTORS - PROPOSED MECHANISM OF MULTIFUNCTIONAL ACTION ON HEMATOPOIETIC PROGENITOR CELLS SO LYMPHOKINE RESEARCH LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,PRI,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 1 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE RES PD WIN PY 1990 VL 9 IS 4 BP 617 EP 617 PG 1 WC Immunology SC Immunology GA EA865 UT WOS:A1990EA86500201 ER PT J AU HOULT, DI DESLAURIERS, R AF HOULT, DI DESLAURIERS, R TI A HIGH-SENSITIVITY, HIGH-B1 HOMOGENEITY PROBE FOR QUANTITATION OF METABOLITES SO MAGNETIC RESONANCE IN MEDICINE LA English DT Article ID TO-NOISE RATIO C1 NATL RES COUNCIL CANADA,DIV BIOL SCI,OTTAWA K1A 0R6,ONTARIO,CANADA. RP HOULT, DI (reprint author), NIH,BIOMED ENGN & INSTRUMENTAT BRANCH,DIV RES SERV,BETHESDA,MD 20892, USA. NR 10 TC 25 Z9 25 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0740-3194 J9 MAGNET RESON MED JI Magn.Reson.Med. PD DEC PY 1990 VL 16 IS 3 BP 411 EP 417 DI 10.1002/mrm.1910160307 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN956 UT WOS:A1990EN95600006 PM 2077331 ER PT J AU HOULT, DI DESLAURIERS, R AF HOULT, DI DESLAURIERS, R TI ELIMINATION OF SIGNAL STRENGTH DEPENDENCY UPON COIL LOADING - AN AID TO METABOLITE QUANTITATION WHEN THE SAMPLE VOLUME CHANGES SO MAGNETIC RESONANCE IN MEDICINE LA English DT Article ID FAST RECOVERY; NMR PROBES; SENSITIVITY C1 NATL RES COUNCIL CANADA,DIV BIOL SCI,OTTAWA K1A 0R6,ONTARIO,CANADA. RP HOULT, DI (reprint author), NIH,BIOMED ENGN & INSTRUMENTAT BRANCH,DIV RES SERV,BETHESDA,MD 20892, USA. NR 15 TC 7 Z9 7 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0740-3194 J9 MAGNET RESON MED JI Magn.Reson.Med. PD DEC PY 1990 VL 16 IS 3 BP 418 EP 424 DI 10.1002/mrm.1910160308 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN956 UT WOS:A1990EN95600007 PM 2077332 ER PT J AU VANZIJL, PCM LIGETI, L SINNWELL, T ALGER, JR CHESNICK, AS MOONEN, CTW MCLAUGHLIN, AC AF VANZIJL, PCM LIGETI, L SINNWELL, T ALGER, JR CHESNICK, AS MOONEN, CTW MCLAUGHLIN, AC TI MEASUREMENT OF CEREBRAL BLOOD-FLOW BY VOLUME-SELECTIVE F-19 NMR-SPECTROSCOPY SO MAGNETIC RESONANCE IN MEDICINE LA English DT Note ID LOCALIZED PROTON SPECTROSCOPY; STIMULATED ECHOES; INVIVO; EXCITATION; P-31; H-1 C1 NIAAA,METAB & MOLEC BIOL LAB,12501 WASHINGTON AVE,ROCKVILLE,MD 20852. NCI,MED BRANCH,BETHESDA,MD 20892. NINCDS,NEUROIMAGING SECT,BETHESDA,MD 20892. NHLBI,CARDIAC BIOENERGET LAB,BETHESDA,MD 20892. NIH,BIOMED ENGN & INSTRUMENTAT BRANCH,DRS,BETHESDA,MD 20892. RI van Zijl, Peter/B-8680-2008; Moonen, Chrit/K-4434-2016 OI Moonen, Chrit/0000-0001-5593-3121 NR 29 TC 11 Z9 11 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0740-3194 J9 MAGNET RESON MED JI Magn.Reson.Med. PD DEC PY 1990 VL 16 IS 3 BP 489 EP 495 DI 10.1002/mrm.1910160316 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN956 UT WOS:A1990EN95600015 PM 2077340 ER PT J AU BAKER, BL MORROW, AL VERGALLA, J PAUL, SM JONES, EA AF BAKER, BL MORROW, AL VERGALLA, J PAUL, SM JONES, EA TI GAMMA-AMINOBUTYRIC-ACID (GABA-A) RECEPTOR-FUNCTION IN A RAT MODEL OF HEPATIC-ENCEPHALOPATHY SO METABOLIC BRAIN DISEASE LA English DT Article DE HEPATIC ENCEPHALOPATHY; GAMMA-AMINOBUTYRIC ACID; CHLORIDE CHANNEL; SYNAPTONEUROSOMES; BENZODIAZEPINE ID BENZODIAZEPINE RECEPTORS; ANIMAL-MODEL; RABBIT MODEL; COMPLEX; FAILURE; BRAIN; PATHOGENESIS; BINDING AB The functional activity of the gamma-aminobutyric acid (GABA(A)) receptor-chloride ionophore complex was studied in rats with hepatic encephalopathy (HE) secondary to thioacetamide-induced fulminant hepatic failure (FHF). Muscimol stimulation and benzodiazepine potentiation of GABA receptor-mediated Cl--36 uptake into cerebral cortical synaptoneurosomes was compared in HE and control rats. [H-3]Flumazenil binding assays were conducted to determine whether the levels of endogenous benzodiazepine-like ligands in extracts of cortex were increased with stages of encephalopathy in this animal model of HE. In both control and HE rats maximal uptake of Cl--36 via the GABA(A) receptor complex occurred at muscimol concentrations of 30-mu-M. Potentiation of muscimol-stimulated Cl--36 uptake into synaptoneurosomes by diazepam (5-mu-M) was equivalent in both groups. Aqueous extracts of proteolytically digested homogenates of cerebral cortices prepared from control and HE rats were effective in stimulating Cl--36 uptake into synaptoneurosomes. Alkaline organic extracts of proteolytically digested homogenates of cerebral cortices from HE rats were more effective than corresponding extracts from controls at inhibiting the binding of [H-3]flumazenil. Inhibition of [H-3] fumazenil binding by organic extracts derived from the cerebral cortices of HE rats did not increase with progression of encephalopathy. The results show that muscimol-stimulated Cl--36 uptake into synaptoneurosomes and, consequently, GABA(A) receptor-mediated chloride channel function are not significantly altered in the model of HE studied and are consistent with the hypothesis that HE results in an increased availability of one or more endogenous ligands which can augment GABA receptor-gated chloride conductance. C1 NIMH,CLIN NEUROSCI BRANCH,MOLEC PHARMACOL SECT,BETHESDA,MD 20892. RP BAKER, BL (reprint author), NIDDKD,DIGEST DIS BRANCH,LIVER DIS SECT,BLDG 10,ROOM 4D-52,BETHESDA,MD 20892, USA. NR 29 TC 9 Z9 9 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0885-7490 J9 METAB BRAIN DIS JI Metab. Brain Dis. PD DEC PY 1990 VL 5 IS 4 BP 185 EP 193 DI 10.1007/BF00997072 PG 9 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA FB708 UT WOS:A1990FB70800003 PM 1965008 ER PT J AU KATZ, A BOGARDUS, C AF KATZ, A BOGARDUS, C TI INSULIN-MEDIATED INCREASE IN GLUCOSE 1,6-BISPHOSPHATE IS ATTENUATED IN SKELETAL-MUSCLE OF INSULIN-RESISTANT MAN SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article C1 NIDDKD,CLIN DIABET & NUTR SECT,PHOENIX,AZ. RP KATZ, A (reprint author), UNIV ILLINOIS,DEPT KINESIOL,906 S GOODWIN AVE,URBANA,IL 61801, USA. NR 24 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0026-0495 J9 METABOLISM JI Metab.-Clin. Exp. PD DEC PY 1990 VL 39 IS 12 BP 1300 EP 1304 DI 10.1016/0026-0495(90)90187-H PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL396 UT WOS:A1990EL39600014 PM 2246971 ER PT J AU RANDALL, PS AF RANDALL, PS TI NEW DDL INFORMATION SO MINNESOTA MEDICINE LA English DT Letter RP RANDALL, PS (reprint author), NIAID,OFF COMMUN,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MINN MED ASSN PI MINNEAPOLIS PA SUITE 400 2221 UNIV AVE S E, MINNEAPOLIS, MN 55414 SN 0026-556X J9 MINN MED PD DEC PY 1990 VL 73 IS 12 BP 12 EP 12 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EL857 UT WOS:A1990EL85700003 PM 2127299 ER PT J AU KIKKAWA, F GONZALEZ, FJ KIMURA, S AF KIKKAWA, F GONZALEZ, FJ KIMURA, S TI CHARACTERIZATION OF A THYROID-SPECIFIC ENHANCER LOCATED 5.5 KILOBASE PAIRS UPSTREAM OF THE HUMAN THYROID PEROXIDASE GENE SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article C1 NCI,MOLEC CARCINOGENESIS LAB,BLDG 37,ROOM 3E24,BETHESDA,MD 20892. RI KIKKAWA, Fumitaka/I-7341-2014 NR 47 TC 68 Z9 70 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6216 EP 6224 PG 9 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200012 PM 2174102 ER PT J AU APLAN, PD BEGLEY, CG BERTNESS, V NUSSMEIER, M EZQUERRA, A COLIGAN, J KIRSCH, IR AF APLAN, PD BEGLEY, CG BERTNESS, V NUSSMEIER, M EZQUERRA, A COLIGAN, J KIRSCH, IR TI THE SCL GENE IS FORMED FROM A TRANSCRIPTIONALLY COMPLEX LOCUS SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article C1 NCI,USN,MED BRANCH,BETHESDA,MD 20814. NCI,PEDIAT ONCOL BRANCH,BETHESDA,MD 20814. ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA. UNIV CALIF LOS ANGELES,MED CTR,DEPT PATHOL,LOS ANGELES,CA 90024. NIAID,IMMUNOGENET LAB,BETHESDA,MD 20814. RI Ezquerra, Angel/I-3440-2012; Aplan, Peter/K-9064-2016; OI Ezquerra, Angel/0000-0002-1824-5087 NR 43 TC 117 Z9 119 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6426 EP 6435 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200035 PM 2247063 ER PT J AU STEARNS, T KAHN, RA BOTSTEIN, D HOYT, MA AF STEARNS, T KAHN, RA BOTSTEIN, D HOYT, MA TI ADP RIBOSYLATION FACTOR IS AN ESSENTIAL PROTEIN IN SACCHAROMYCES-CEREVISIAE AND IS ENCODED BY 2 GENES SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article C1 NCI,DIV CANC TREATMENT,BIOL CHEM LAB,BETHESDA,MD 20892. MIT,DEPT BIOL,CAMBRIDGE,MA 02139. FU NIGMS NIH HHS [GM07287, GM21253, GM18973] NR 46 TC 214 Z9 220 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6690 EP 6699 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200063 PM 2123295 ER PT J AU SWERGOLD, GD AF SWERGOLD, GD TI IDENTIFICATION, CHARACTERIZATION, AND CELL SPECIFICITY OF A HUMAN LINE-1 PROMOTER SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article RP SWERGOLD, GD (reprint author), NCI,BIOCHEM LAB,BLDG 37,ROOM 4A-01,BETHESDA,MD 20892, USA. NR 63 TC 251 Z9 257 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6718 EP 6729 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200066 PM 1701022 ER PT J AU STANTON, BR REID, SW PARADA, LF AF STANTON, BR REID, SW PARADA, LF TI GERM LINE TRANSMISSION OF AN INACTIVE N-MYC ALLELE GENERATED BY HOMOLOGOUS RECOMBINATION IN MOUSE EMBRYONIC STEM-CELLS SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Note C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21701. RI Parada, luis/B-9400-2014 FU NCI NIH HHS [N01-CO-74101] NR 16 TC 32 Z9 32 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6755 EP 6758 PG 4 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200069 PM 1701023 ER PT J AU SAX, CM KLEMENT, JF PIATIGORSKY, J AF SAX, CM KLEMENT, JF PIATIGORSKY, J TI SPECIES-SPECIFIC LENS ACTIVATION OF THE THYMIDINE KINASE PROMOTER BY A SINGLE COPY OF THE MOUSE ALPHA-A-CRYBP1 SITE AND LOSS OF TISSUE-SPECIFICITY BY MULTIMERIZATION SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Note RP SAX, CM (reprint author), NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892, USA. NR 33 TC 24 Z9 24 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6813 EP 6816 PG 4 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200080 PM 2247086 ER PT J AU SCULLY, SP JOYCE, ME ABIDI, N BOLANDER, ME AF SCULLY, SP JOYCE, ME ABIDI, N BOLANDER, ME TI THE USE OF POLYMERASE CHAIN-REACTION GENERATED NUCLEOTIDE-SEQUENCES AS PROBES FOR HYBRIDIZATION SO MOLECULAR AND CELLULAR PROBES LA English DT Article C1 NIAMS,ORTHOPED RES UNIT,BETHESDA,MD 20892. NR 15 TC 35 Z9 35 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD DEC PY 1990 VL 4 IS 6 BP 485 EP 495 DI 10.1016/0890-8508(90)90007-M PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA EL387 UT WOS:A1990EL38700007 PM 2087236 ER PT J AU RAYCHAUDHURI, B NEBERT, DW PUGA, A AF RAYCHAUDHURI, B NEBERT, DW PUGA, A TI THE MURINE CYP1A-1 GENE NEGATIVELY REGULATES ITS OWN TRANSCRIPTION AND THAT OF OTHER MEMBERS OF THE AROMATIC HYDROCARBON-RESPONSIVE [AH] GENE BATTERY SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID AMINO-ACID SEQUENCE; CYTOCHROME-P1-450 GENE; NUCLEOTIDE-SEQUENCE; P-450C GENE; P1450 GENE; EXPRESSION; DNA; DIOXIN; CDNA; ELEMENTS AB Transcripts of the murine CYP1A1 (cytochrome P450(1)) mRNA are markedly elevated in mutant hepatoma cell lines that contain missense mutations in the Cyp1a-1 structural gene. This putative derepression extends to other genes in the ]Ah[ battery. To test whether the Cyp1a-1 gene product is involved in a mechanism of feedback regulation of transcription, we introduced expression plasmids carrying the murine wild-type Cyp1a-1 cDNA into the mutant hepatoma cells. Measurements of steady-state mRNA levels and of transcriptional rates in the transfectants reveal that expression of a functional, exogenous CYP1A1 protein is sufficient to restore the repression of the endogenous gene, as well as restore the inducibility by dioxin, and that this effect takes place primarily at the level of transcription. Similar experiments with expression plasmids that carry the human CYP1A2 cDNA indicate that the CYP1A2 protein (cytochrome p450(3)) can also function as a transcriptional repressor. In addition, we find that expression of the Nmo-1[Nad(P)H:menadione oxidoreductase] gene, a third member of the [Ah] gene battery, is also repressed by the exogenous expression of either Cyp1a-1 or CYP1A2 cDNA. These results indicate that the gene product of either member of the mammalian CYP1 family has a previously unrecognized tanscriptional regulatory function, which is likely to be exerted by modification of preexisting trans-acting factors. This function may help bring about a fast reprogramming of gene expression, as might be needed during detoxification of toxic foreign chemicals. (Molecular Endocrinology 4: 1773-1781, 1990) C1 NICHHD,DEV PHARMACOL LAB,BLDG 6,ROOM 416,BETHESDA,MD 20892. RI Puga, Alvaro/B-7676-2008 NR 38 TC 53 Z9 53 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD DEC PY 1990 VL 4 IS 12 BP 1773 EP 1781 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EQ428 UT WOS:A1990EQ42800002 PM 2082180 ER PT J AU BROWN, AL RECHLER, MM AF BROWN, AL RECHLER, MM TI CLONING OF THE RAT INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-2 GENE AND IDENTIFICATION OF A FUNCTIONAL PROMOTER LACKING A TATA BOX SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID HUMAN AMNIOTIC-FLUID; POLYMERASE-II TRANSCRIPTION; HUMAN CEREBROSPINAL-FLUID; 5' UNTRANSLATED REGIONS; FACTOR RECEPTOR GENE; MESSENGER-RNA; IGF-I; TISSUE DISTRIBUTION; SEQUENCE-ANALYSIS; MAMMALIAN-CELLS AB We have isolated clones encoding the rat insulin-like growth factor-binding protein-2 (IGFBP-2) gene and determined its organization and nucleotide sequence. The rat IGFBP-2 gene spans at least 8 kilobases and consists of four exons, each of which contains protein-coding sequences. The amino acid sequences of exons 1,3, and 4 are 32-50% identical to the corresponding exons of human IGFBP-1 and IGFBP-3, and 87-91% identical to those of human IGFBP-2. The 18 cysteines in the mature binding proteins are conserved. Exon 2 shows negligible homology. Primer-extended reverse transcription indicated that the 5' end of IGFBP-2 mRNA is 151 nucleotides up-stream from the translation start site [designated nucleotide (nt) -151]. Consistent with this result, IGFBP-2 mRNA protected a genomic fragment terminating at approximately nt -148, as well as smaller fragments. A 1260 nt fragment containing 1144 nt of 5' flanking region had promoter activity when inserted in the correct orientation into a plasmid containing a promoterless luciferase reporter gene and transiently transfected into BRL-3A rat liver cells, which express IGFBP-2, but not when transfected into H4-II-E cells, which do not express IGFBP-2. The IGFBP-2 gene lacks a TATA box immediately up-stream from the transcription initiation site. It is GC rich (66% between nt -270 and 385) and contains GC boxes that might be recognized by transcription factors Sp1 or ETF. The promoter region contains multiple direct and indirect repeats. One direct repeat contains a variant Sp1 site (-158 to -150) near the consensus Sp1 site at nt -138 to -130. The 5' flanking region also contains motifs that might be recognized by transcription factors AP-1 (Jun/Fos), AP-2, and liver factor B1. The role of these sites in basal and regulated expression of the IGFBP-2 gene remains to be determined. (Molecular Endocrinology 4: 2039-2051, 1990) RP BROWN, AL (reprint author), NIDDKD,MOLEC CELLULAR & NUTR ENDOCRINOL BRANCH,GROWTH & DEV SECT,BLDG 10,ROOM 8D14,BETHESDA,MD 20892, USA. NR 92 TC 61 Z9 62 U1 0 U2 2 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD DEC PY 1990 VL 4 IS 12 BP 2039 EP 2051 PG 13 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EQ428 UT WOS:A1990EQ42800032 PM 1707131 ER PT J AU LASZLO, G DICKLER, HB AF LASZLO, G DICKLER, HB TI REGULATION OF FC-GAMMA-R-II EXPRESSION AND FUNCTION BY LYMPHOCYTE-B ACTIVATORS SO MOLECULAR IMMUNOLOGY LA English DT Article ID FC-GAMMA-RECEPTORS; INDEPENDENT LIGAND OCCUPANCY; ANTIGEN-ANTIBODY COMPLEXES; CROSS-LINKING; SURFACE-IMMUNOGLOBULIN; MURINE LYMPHOCYTES; CELL ACTIVATION; DIFFERENTIATION; STIMULATION; MOLECULES AB B lymphocytes cultured with LPS show increased expression of Fc-gamma-R II and increased binding of Ag-IgG complexes (both > 200%). In contrast, B lymphocytes cultured with either IL-4 or anti-mu-show a marked loss (85-90%) of binding of Ag-IgG complexes that is specific, time and temperature dependent, and reversible. Decreased binding of complexes was not due to decreased expression of the receptor and therefore appears to be due to some form of alteration of the receptor. Based on the observation that the loss of binding of complexes requires protein synthesis, we favor the view that the loss is due to association of Fc-gamma-R II with another membrane molecule whose expression is induced or increased by IL-4 or anti-mu-. Anti-mu-induced loss of Fc-gamma-R II ligand binding capacity does not require cross-linking of surface IgM because the effect can be generated with F(ab') anti-mu-. Anti-mu-induced loss of Fc-gamma-R II binding of complexes was substantially prevented by IFN-gamma, did not reduce the anti-mu caused increase in expression of MHC class II molecules. This result shows that increased expression of the latter molecules can be dissociated from loss of Fc-gamma-R II ligand binding capacity. A myeloid cell line was identified that constitutively expresses Fc-gamma-R II binds relatively few complexes. This cell line may be useful in identifying alterations of Fc-gamma-R II which lead to the loss of binding of complexes. These results indicate that various B lymphocyte activators have different effects on B lymphocyte expression and function, and can thereby affect Fc-gamma-R II generated regulatory signals. C1 NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 29 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD DEC PY 1990 VL 27 IS 12 BP 1189 EP 1193 DI 10.1016/0161-5890(90)90021-Q PG 5 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA EU557 UT WOS:A1990EU55700004 PM 2148803 ER PT J AU SEGAL, DM GARRIDO, MA QIAN, JH MEZZANANICA, D ANDREW, S PEREZ, P KURUCZ, I VALDAYO, MJ TITUS, JA WINKLER, DF WUNDERLICH, JR AF SEGAL, DM GARRIDO, MA QIAN, JH MEZZANANICA, D ANDREW, S PEREZ, P KURUCZ, I VALDAYO, MJ TITUS, JA WINKLER, DF WUNDERLICH, JR TI EFFECTORS OF TARGETED CELLULAR CYTOTOXICITY SO MOLECULAR IMMUNOLOGY LA English DT Article ID TOXIC LYMPHOCYTES-T; NATURAL-KILLER CELLS; PREVENT TUMOR-GROWTH; RECEPTOR ANTIBODIES; MONOCLONAL-ANTIBODY; CYTO-TOXICITY; ANTIGEN; ACTIVATION; LYSIS; ADHESION RP SEGAL, DM (reprint author), NCI,EXPTL IMMUNOL BRANCH,BLDG 10,ROOM 4B17,BETHESDA,MD 20892, USA. RI Perez, Pilar/B-4948-2010; Mezzanzanica, Delia/C-2607-2017 OI Perez, Pilar/0000-0003-3557-2247; Mezzanzanica, Delia/0000-0002-9664-6871 NR 31 TC 6 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD DEC PY 1990 VL 27 IS 12 BP 1339 EP 1342 DI 10.1016/0161-5890(90)90040-7 PG 4 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA EU557 UT WOS:A1990EU55700023 PM 2274063 ER PT J AU FLYNN, JL WEISS, WR NORRIS, KA SEIFERT, HS KUMAR, S SO, M AF FLYNN, JL WEISS, WR NORRIS, KA SEIFERT, HS KUMAR, S SO, M TI GENERATION OF A CYTOTOXIC LYMPHOCYTE-T RESPONSE USING A SALMONELLA ANTIGEN-DELIVERY SYSTEM SO MOLECULAR MICROBIOLOGY LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; MALARIA SPOROZOITES; PLASMODIUM-YOELII; TYPHIMURIUM; MICE; IMMUNITY; VACCINES; CELLS; STRAINS; IMMUNIZATION AB We have constructed a general-use vector for the cloning and stable expression of foreign genes in the chromosome of attenuated Salmonella typhimurium. Using this chromosomal expression vector (CEV), we expressed the circumsporozoite (CS) gene of the mouse malaria Plasmodium yoelii in an aroA S. typhimurium strain. Mice immunized with CS-expressing Salmonella recombinants mount a CS-specific cytotoxic T-lymphocyte (CTL) response. This is the first demonstration that attenuated Salmonella can elicit a specific CTL response to a foreign protein in mice. The ability to easily and stably express foreign genes from the Salmonella chromosome and the generation of specific CTL greatly expands the potential of Salmonella as an antigen-delivery system. C1 NIH, PARASIT DIS LAB, BETHESDA, MD 20892 USA. USN, MED RES INST, DEPT INFECT DIS, BETHESDA, MD 20814 USA. NORTHWESTERN UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, CHICAGO, IL 60611 USA. RP FLYNN, JL (reprint author), Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA. FU NIAID NIH HHS [AI07343] NR 28 TC 105 Z9 105 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD DEC PY 1990 VL 4 IS 12 BP 2111 EP 2118 DI 10.1111/j.1365-2958.1990.tb00572.x PG 8 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA ER456 UT WOS:A1990ER45600014 PM 2089224 ER PT J AU RABE, CS TABAKOFF, B AF RABE, CS TABAKOFF, B TI GLYCINE SITE-DIRECTED AGONISTS REVERSE THE ACTIONS OF ETHANOL AT THE N-METHYL-D-ASPARTATE RECEPTOR SO MOLECULAR PHARMACOLOGY LA English DT Note ID CEREBELLAR GRANULE CELLS; HIPPOCAMPAL-NEURONS; GLUTAMATE; INHIBITION; CHANNEL; RELEASE; BRAIN AB Ethanol has been shown to inhibit N-methyl-D-aspartate (NMDA)-stimulated calcium influx into cerebellar granule cells grown in culture. Because NMDA-mediated responses are modulated by a number of substances, we investigated the effects of several of these agents on ethanol-induced inhibition of calcium flux. Ethanol (50 mM) inhibited NMDA-dependent Ca2+ influx by approximately 50%. The percentage of inhibition remained constant with increasing NMDA concentrations (5-250-mu-M). Increasing Mg2+ concentrations in the assay medium inhibited NMDA-stimulated calcium influx but the EC50 for Mg2+ was unchanged in the presence of ethanol. Glycine at concentrations of 0.3-100-mu-M potentiated the effects of NMDA. Glycine at concentrations in excess of 10-mu-M decreased ethanol-mediated inhibition of NMDA-stimulated calcium influx. D-Serine was shown to have effects similar to those of glycine, whereas L-serine was significantly less active in potentiating NMDA-stimulated activity and reversing the ethanol-induced inhibition of calcium influx. N-Methylglycine and L-leucine were ineffective in potentiating NMDA actions but high concentrations (1 mM) of N-methylglycine attenuated ethanol-induced inhibition, whereas L-leucine (1 mM) had no effect. High concentrations of N-methylglycine were shown to reduce glycine-induced enhancement at the NMDA receptor, whereas L-leucine did not affect the glycine response. Glycine did not affect kainate-stimulated calcium influx and did not alter the small amount of inhibition produced by ethanol in the response of the cells to kainate. The results demonstrate that the in vivo actions of ethanol on the NMDA systems of brain may be dependent on glycine concentrations at these receptor sites. C1 NIAAA,DIV INTRAMURAL CLIN & BIOL RES,SPECIAL PROJECTS UNIT,BETHESDA,MD 20892. NR 20 TC 142 Z9 142 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD DEC PY 1990 VL 38 IS 6 BP 753 EP 757 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EQ116 UT WOS:A1990EQ11600001 PM 1701211 ER PT J AU WESS, J BONNER, TI BRANN, MR AF WESS, J BONNER, TI BRANN, MR TI CHIMERIC M2/M3 MUSCARINIC RECEPTORS - ROLE OF CARBOXYL TERMINAL RECEPTOR DOMAINS IN SELECTIVITY OF LIGAND-BINDING AND COUPLING TO PHOSPHOINOSITIDE HYDROLYSIS SO MOLECULAR PHARMACOLOGY LA English DT Article ID BETA-ADRENERGIC-RECEPTOR; ACETYLCHOLINE-RECEPTOR; BETA-2-ADRENERGIC RECEPTORS; SUBTYPES; EXPRESSION; IDENTIFICATION; ANTAGONIST; GENES; CELLS; DNA AB The cloning and expression of five mammalian muscarinic receptor genes (m1-m5) have shown that the individual receptor subtypes differ in their functional and ligand-binding properties. To study the role of the carboxyl terminal receptor domains in this pharmacological diversity, we constructed chimeric m2/m3 receptors in which a region comprising part of transmembrane domain VI, the third extracellular loop, transmembrane region VII, and the cytoplasmic tail (collectively referred to as C-terminal domains) was exchanged between the human m2 and the rat m3 receptor. The ability of the cloned receptors to mediate stimulation of phosphoinositide hydrolysis and to bind subtype-selective muscarinic ligands was studied after their transient expression in COS-7 cells. Whereas wild-type m3 strongly stimulated phosphoinositide breakdown, wild-type m2 gave only a poor response. Exchange of the C-terminal domains between m2 and m3 had no significant effect on the magnitude of these responses. In N-[H-3]methylscopolamine competition binding studies, the muscarinic antagonists AF-DX 116 and methoctramine showed 11- and 23-fold higher affinities, respectively, for m2 than for m3, whereas hexahydro-silad-ifenidol (HHSiD) and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) displayed the reverse selectivity profile, having approximately 10-fold higher affinities for m3. In comparison with wild-type m3, the mutant m3 receptor containing the C-terminal domains of m2 displayed 2.5- and 8-fold higher affinities for AF-DX 116 and methoctramine but 7- and 3-fold lower affinities for HHSiD and 4-DAMP, respectively. The mutant m2 receptor with the C-terminal domains of m3 showed 2-3-fold lower affinities for AF-DX 116 and methoctramine but 2-3-fold higher affinities for HHSiD and 4-DAMP, as compared with wild-type m2. These data suggest that the C-terminal domains of the muscarinic receptors are not involved in conferring selectivity of coupling to phosphoinositide hydrolysis but contain major structural determinants of antagonist binding selectivity. C1 NIMH,CELL BIOL LAB,BETHESDA,MD 20892. RP WESS, J (reprint author), NINCDS,MOLEC BIOL LAB,BLDG 36,ROOM 3D-02,BETHESDA,MD 20892, USA. NR 39 TC 63 Z9 63 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD DEC PY 1990 VL 38 IS 6 BP 872 EP 877 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EQ116 UT WOS:A1990EQ11600017 PM 2174507 ER PT J AU SARKAR, FH RADCLIFF, G CALLEWAERT, DM MARNETT, LJ ELING, T DASTON, DS CASPARY, WJ AF SARKAR, FH RADCLIFF, G CALLEWAERT, DM MARNETT, LJ ELING, T DASTON, DS CASPARY, WJ TI MUTAGENIC RESPONSE OF MOUSE LYMPHOMA-CELLS AFTER ACTIVATION OF BENZIDINE AND 2-AMINOFLUORENE WITH PURIFIED PROSTAGLANDIN-H SYNTHASE SO MUTATION RESEARCH LA English DT Article C1 OXFORD BIOMED RES INC,ROCHESTER,MI 48309. WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202. NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709. NIEHS,CELLULAR & GENET TOXICOL BRANCH,RES TRIANGLE PK,NC 27709. FU NIEHS NIH HHS [N44-ES-61008] NR 22 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8262 J9 MUTAT RES PD DEC PY 1990 VL 242 IS 4 BP 319 EP 328 DI 10.1016/0165-1218(90)90050-C PG 10 WC Genetics & Heredity; Toxicology SC Genetics & Heredity; Toxicology GA EL253 UT WOS:A1990EL25300007 PM 2123966 ER PT J AU BELAND, FA FULLERTON, NF MARQUES, MM MELCHIOR, WB SMITH, BA POIRIER, C AF BELAND, FA FULLERTON, NF MARQUES, MM MELCHIOR, WB SMITH, BA POIRIER, C TI DNA ADDUCT FORMATION IN RELATION TO TUMORIGENESIS IN MICE CONTINUOUSLY ADMINISTERED AROMATIC AMINE CARCINOGENS SO MUTATION RESEARCH LA English DT Meeting Abstract C1 NATL CTR TOXICOL RES,JEFFERSON,AR 72079. NCI,BETHESDA,MD 20892. RI Marques, M. Matilde/E-2535-2012 OI Marques, M. Matilde/0000-0002-7526-4962 NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8262 J9 MUTAT RES PD DEC PY 1990 VL 234 IS 6 BP 371 EP 371 DI 10.1016/0165-1161(90)90054-R PG 1 WC Genetics & Heredity; Toxicology SC Genetics & Heredity; Toxicology GA EK540 UT WOS:A1990EK54000006 ER PT J AU ZHANG, WQ ROGERS, BC TANDON, P HUDSON, PM SOBOTKA, TJ HONG, JS TILSON, HA AF ZHANG, WQ ROGERS, BC TANDON, P HUDSON, PM SOBOTKA, TJ HONG, JS TILSON, HA TI SYSTEMIC ADMINISTRATION OF KAINIC ACID INCREASES GABA LEVELS IN PERFUSATE FROM THE HIPPOCAMPUS OF RATS INVIVO SO NEUROTOXICOLOGY LA English DT Article DE KAINIC ACID; AMINO ACID RELEASE; GABA; HIPPOCAMPUS; MICRODIALYSIS ID SUSTAINED ELECTRICAL-STIMULATION; TEMPORAL-LOBE EPILEPSY; PERFORANT PATH; BRAIN-REGIONS; AMINO-ACIDS; KAINATE; RELEASE; ASPARTATE; RECEPTORS; DAMAGE AB The ventral hippocampi of male, Fischer-344 rats were implanted with microdialysis probes and the effects of systemically administered kainic acid (KA) (8 mg/kg, s.c.) on the in vivo release of amino acids were measured for four hours after administration. In order to measure GABA release in vivo, gamma-vinyl-GABA (GVG), an irreversible inhibitor of GABA transaminase, was injected intrahippocampally prior to perfusion. GVG pretreatment resulted in measurable levels of GABA in the perfusate without significant effects on the release of aspartate, glutamate, glutamine, glycine or taurine. Following GVG pretreatment systemic administration of KA produced a time-dependent increase in GABA, as well as all other amino acids except glutamine, which was initially decreased. These results show for the first time that systemically administered KA increases extracellular GABA levels, an effect previously reported only in vitro. These data suggest that prior to destruction of GABA-containing interneurons in the hippocampus, there is an increased activity of those GABA interneuros reflected as an increase in extracellular GABA levels. C1 US EPA,HLTH EFFECTS RES LAB,DIV NEUROTOXICOL MD74B,RES TRIANGLE PK,NC 27711. NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,RES TRIANGLE PK,NC 27709. US FDA,NEUROBEHAV TOXICOL TEAM,WASHINGTON,DC 20204. FU FDA HHS [FDA 224-87-2436] NR 36 TC 23 Z9 24 U1 0 U2 0 PU INTOX PRESS INC PI LITTLE ROCK PA PO BOX 24865, LITTLE ROCK, AR 72221 SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD WIN PY 1990 VL 11 IS 4 BP 593 EP 600 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA EQ384 UT WOS:A1990EQ38400003 PM 2087285 ER PT J AU PALMER, MH AF PALMER, MH TI URINARY-INCONTINENCE SO NURSING CLINICS OF NORTH AMERICA LA English DT Article RP PALMER, MH (reprint author), NIA,GERONTOL RECH CTR,BEHAV SCI LAB,4940 EASTERN AVE,BALTIMORE,MD 21224, USA. NR 77 TC 3 Z9 3 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD DEC PY 1990 VL 25 IS 4 BP 919 EP 934 PG 16 WC Nursing SC Nursing GA EJ002 UT WOS:A1990EJ00200018 PM 2235644 ER PT J AU BUCKWALTER, KC BABICH, KS AF BUCKWALTER, KC BABICH, KS TI PSYCHOLOGIC AND PHYSIOLOGICAL-ASPECTS OF DEPRESSION SO NURSING CLINICS OF NORTH AMERICA LA English DT Article C1 NIMH,DIV BIOMETRY & APPL SCI,BETHESDA,MD 20892. RP BUCKWALTER, KC (reprint author), UNIV IOWA,COLL NURSING,OFF NURSING RES DEV & UTILIZAT,IOWA CITY,IA 52242, USA. NR 11 TC 2 Z9 2 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD DEC PY 1990 VL 25 IS 4 BP 945 EP 954 PG 10 WC Nursing SC Nursing GA EJ002 UT WOS:A1990EJ00200020 PM 2235646 ER PT J AU SETH, A PAPAS, TS AF SETH, A PAPAS, TS TI THE C-ETS-1 PROTOONCOGENE HAS ONCOGENIC ACTIVITY AND IS POSITIVELY AUTOREGULATED SO ONCOGENE LA English DT Article ID AUTO-REGULATION; ETS GENES; MYC; EXPRESSION; ENHANCER; DAUGHTERLESS; SEQUENCE; PROTEINS; COMPLEX; BINDING AB The proto-oncogene ets-1 is a member of the ets family of genes that share homology with the viral oncogene, v-ets, of the avian leukemia virus E26. By using expression vectors, we demonstrate that the ets-1 gene transforms NIH3T3 cells and the ets-1 transfected cells from colonies in soft agar and induce tumors in nude mice. We have also determined that the ets-1 protein contains homology with the helix-loop-helix motif of the HLH family proteins, but lacks the basic domain upstream of helix I. Transfection of the NIH3T3 cells with ets-1 vectors results in the activation of the endogenous ets-1 gene. Using hybridization probes that can distinguish between transcripts from endogenous and exogenous templates, we show that the endogenous ets-1 gene is activated by the expression of the transfected exogenous ets-1. In contrast, the expression of transfected ets-2 has no effect on the endogenous ets-1 gene expression. The results indicate that the ets-1 proto-oncogene is positively autoregulated by its product. RP SETH, A (reprint author), NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702, USA. NR 38 TC 154 Z9 154 U1 0 U2 2 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD DEC PY 1990 VL 5 IS 12 BP 1761 EP 1767 PG 7 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA ET436 UT WOS:A1990ET43600004 PM 2284095 ER PT J AU SITHANANDAM, G KOLCH, W DUH, FM RAPP, UR AF SITHANANDAM, G KOLCH, W DUH, FM RAPP, UR TI COMPLETE CODING SEQUENCE OF A HUMAN B-RAF CDNA AND DETECTION OF B-RAF PROTEIN-KINASE WITH ISOZYME SPECIFIC ANTIBODIES SO ONCOGENE LA English DT Article ID SIGNAL TRANSDUCTION; BIOLOGICAL-ACTIVITY; FISSION YEAST; A-RAF; V-RAF; ONCOGENE; GENES; MIL; PHOSPHORYLATION; REQUIREMENT AB A 2.2kb cDNA clone which presumably includes the complete human B-raf coding sequence was isolated from a human testes cDNA library. Sequence analysis showed the presence of all three conserved regions CR1, CR2 and CR3 previously identified in raf protein kinases. The cDNA was expressed in E. coli yielding a B-raf fusion protein which reacts with antibodies specific for B-raf raised against the C-terminal peptide as well as with monoclonal antibodies which map into the kinase domain. C1 NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702. NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,FREDERICK,MD 21702. OI Kolch, Walter/0000-0001-5777-5016 NR 32 TC 75 Z9 78 U1 0 U2 6 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD DEC PY 1990 VL 5 IS 12 BP 1775 EP 1780 PG 6 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA ET436 UT WOS:A1990ET43600006 PM 2284096 ER PT J AU EVANS, SL LLOYD, HA LEBEAU, D SOKOLOSKI, EB AF EVANS, SL LLOYD, HA LEBEAU, D SOKOLOSKI, EB TI TRANSFORMATION OF SOME BETA-TETRALONES TO 1,3-DIFORMYL-2-CHLORONAPTHALENES SO ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL LA English DT Note C1 NHLBI,CHEM LAB,BETHESDA,MD 20892. RP EVANS, SL (reprint author), MEHARRY MED COLL,DEPT PHARMACOL,NASHVILLE,TN 37208, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ORGANIC PREP PROCEDURES INC PI NEWTON HIGHLANDS PA PO BOX 9, NEWTON HIGHLANDS, MA 02161 SN 0030-4948 J9 ORG PREP PROCED INT JI Org. Prep. Proced. Int. PD DEC PY 1990 VL 22 IS 6 BP 764 EP 766 PG 3 WC Chemistry, Organic SC Chemistry GA EJ903 UT WOS:A1990EJ90300006 ER PT J AU AMMANN, AJ AF AMMANN, AJ TI BIOLOGIC AND IMMUNOMODULATING FACTORS IN THE TREATMENT OF PEDIATRIC ACQUIRED-IMMUNODEFICIENCY-SYNDROME SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article RP AMMANN, AJ (reprint author), NCI,PEDIAT BRANCH,BETHESDA,MD 20892, USA. NR 41 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD DEC PY 1990 VL 9 IS 12 BP 894 EP 904 PG 11 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA EN191 UT WOS:A1990EN19100008 PM 1703652 ER PT J AU GRAFMAN, J JONAS, B SALAZAR, A AF GRAFMAN, J JONAS, B SALAZAR, A TI WISCONSIN CARD SORTING TEST-PERFORMANCE BASED ON LOCATION AND SIZE OF NEUROANATOMICAL LESION IN VIETNAM VETERANS WITH PENETRATING HEAD-INJURY SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article C1 US CENSUS DEPT,GAITHERSBURG,MD. WALTER REED ARMY MED CTR,DEPT NEUROL,ARMY HEAD INJURY UNIT,WASHINGTON,DC 20307. RP GRAFMAN, J (reprint author), NINCDS,MED NEUROL BRANCH,COGNIT NEUROSCI SECT,BLDG 10,ROOM 5C422,BETHESDA,MD 20892, USA. OI Grafman, Jordan H./0000-0001-8645-4457 NR 14 TC 90 Z9 91 U1 0 U2 1 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD DEC PY 1990 VL 71 IS 3 BP 1120 EP 1122 DI 10.2466/PMS.71.8.1120-1122 PN 2 PG 3 WC Psychology, Experimental SC Psychology GA EW532 UT WOS:A1990EW53200014 PM 2087366 ER PT J AU WALKER, JM BOWEN, WD WALKER, FO MATSUMOTO, RR DECOSTA, B RICE, KC AF WALKER, JM BOWEN, WD WALKER, FO MATSUMOTO, RR DECOSTA, B RICE, KC TI SIGMA-RECEPTORS - BIOLOGY AND FUNCTION SO PHARMACOLOGICAL REVIEWS LA English DT Review ID GUINEA-PIG BRAIN; DEXTROMETHORPHAN BINDING-SITES; POTENTIAL ANTIPSYCHOTIC DRUG; MAGNOCELLULAR RED NUCLEUS; NEUROPEPTIDE-Y DISTRIBUTION; CENTRAL NERVOUS-SYSTEM; LONG-TERM TREATMENT; RAT-BRAIN; HIGH-AFFINITY; OPIATE RECEPTORS C1 BROWN UNIV,DIV BIOL & MED,BIOCHEM SECT,PROVIDENCE,RI 02912. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROL,WINSTON SALEM,NC 27103. NIDDKD,MED CHEM LAB,BETHESDA,MD. RP WALKER, JM (reprint author), BROWN UNIV,DEPT PSYCHOL,SCHRIER RES LAB,POB 1853,89 WATERMAN ST,PROVIDENCE,RI 02912, USA. FU NIDA NIH HHS [DA04988, DA05721]; NINDS NIH HHS [NS26746] NR 267 TC 813 Z9 821 U1 2 U2 15 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-6997 J9 PHARMACOL REV JI Pharmacol. Rev. PD DEC PY 1990 VL 42 IS 4 BP 355 EP 402 PG 48 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EQ149 UT WOS:A1990EQ14900003 PM 1964225 ER PT J AU HAVLIN, S LARRALDE, H KOPELMAN, R WEISS, GH AF HAVLIN, S LARRALDE, H KOPELMAN, R WEISS, GH TI STATISTICAL PROPERTIES OF THE DISTANCE BETWEEN A TRAPPING CENTER AND A UNIFORM DENSITY OF DIFFUSING PARTICLES IN 2 DIMENSIONS SO PHYSICA A LA English DT Article ID REACTION-KINETICS; MEDIA AB Several analyses of self-segregation properties of reaction-diffusion systems in low dimensions have been based on a simplified model in which an initially uniform concentration of point particles is depleted by reaction with an immobilized trap. A measure of self-segregation in this system is the distance of the trap from the nearest untrapped particle. In one dimension the average of this distance has been shown to increase at a rate proportional to t1/4. We show that this rate in a two-dimensional system is asymptotically proportional to (ln t)1/2, and that the concentration profile in the neighborhood of the trap is proportional to (ln r/ln t). C1 BAR ILAN UNIV,DEPT PHYS,IL-52100 RAMAT GAN,ISRAEL. BOSTON UNIV,DEPT PHYS,BOSTON,MA 02215. UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109. RP HAVLIN, S (reprint author), NIH,PHYS SCI LAB,BETHESDA,MD 20892, USA. NR 11 TC 33 Z9 33 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD DEC 1 PY 1990 VL 169 IS 3 BP 337 EP 341 DI 10.1016/0378-4371(90)90105-2 PG 5 WC Physics, Multidisciplinary SC Physics GA ET902 UT WOS:A1990ET90200001 ER PT J AU DOHERTY, GM NORTON, JA AF DOHERTY, GM NORTON, JA TI PREOPERATIVE AND INTRAOPERATIVE LOCALIZATION OF GASTRINOMAS SO PROBLEMS IN GENERAL SURGERY LA English DT Article C1 NCI,SURG BRANCH,SURG METAB SECT,BLDG 10,ROOM 2B07,BETHESDA,MD 20892. NR 0 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0739-8328 J9 PROBL GEN SURG PD DEC PY 1990 VL 7 IS 4 BP 521 EP 532 PG 12 WC Surgery SC Surgery GA EN187 UT WOS:A1990EN18700004 ER PT J AU GOOD, PJ RICHTER, K DAWID, IB AF GOOD, PJ RICHTER, K DAWID, IB TI A NERVOUS SYSTEM-SPECIFIC ISOTYPE OF THE BETA-SUBUNIT OF NA+,K+-ATPASE EXPRESSED DURING EARLY DEVELOPMENT OF XENOPUS-LAEVIS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. AUSTRIAN ACAD SCI,INST MOLEC BIOL,A-5020 SALZBURG,AUSTRIA. NR 50 TC 115 Z9 116 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9088 EP 9092 DI 10.1073/pnas.87.23.9088 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600004 PM 2174552 ER PT J AU KAMBADUR, R CULOTTA, V HAMER, D AF KAMBADUR, R CULOTTA, V HAMER, D TI CLONED YEAST AND MAMMALIAN TRANSCRIPTION FACTOR-TFIID GENE-PRODUCTS SUPPORT BASAL BUT NOT ACTIVATED METALLOTHIONEIN GENE-TRANSCRIPTION SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article RP KAMBADUR, R (reprint author), NCI,BIOCHEM LAB,BETHESDA,MD 20892, USA. NR 44 TC 28 Z9 28 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9168 EP 9172 DI 10.1073/pnas.87.23.9168 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600020 PM 2251259 ER PT J AU MIZROKHI, LJ MAZO, AM AF MIZROKHI, LJ MAZO, AM TI EVIDENCE FOR HORIZONTAL TRANSMISSION OF THE MOBILE ELEMENT JOCKEY BETWEEN DISTANT DROSOPHILA SPECIES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. RP MIZROKHI, LJ (reprint author), NCI,BIOCHEM LAB,BETHESDA,MD 20892, USA. NR 24 TC 82 Z9 85 U1 2 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9216 EP 9220 DI 10.1073/pnas.87.23.9216 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600030 PM 1701254 ER PT J AU GARCIAMORALES, P MINAMI, Y LUONG, E KLAUSNER, RD SAMELSON, LE AF GARCIAMORALES, P MINAMI, Y LUONG, E KLAUSNER, RD SAMELSON, LE TI TYROSINE PHOSPHORYLATION IN T-CELLS IS REGULATED BY PHOSPHATASE-ACTIVITY - STUDIES WITH PHENYLARSINE OXIDE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article RP GARCIAMORALES, P (reprint author), NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892, USA. NR 25 TC 279 Z9 281 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9255 EP 9259 DI 10.1073/pnas.87.23.9255 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600038 PM 1701256 ER PT J AU MENETSKI, JP GELLERT, M AF MENETSKI, JP GELLERT, M TI V(D)J RECOMBINATION ACTIVITY IN LYMPHOID-CELL LINES IS INCREASED BY AGENTS THAT ELEVATE CAMP SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article RP MENETSKI, JP (reprint author), NIDDKD,MOLEC BIOL LAB,BETHESDA,MD 20892, USA. NR 26 TC 63 Z9 63 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9324 EP 9328 DI 10.1073/pnas.87.23.9324 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600052 PM 1701258 ER PT J AU MILLER, RH GIRONES, R COTE, PJ HORNBUCKLE, WE CHESTNUT, T BALDWIN, BH KORBA, BE TENNANT, BC GERIN, JL PURCELL, RH AF MILLER, RH GIRONES, R COTE, PJ HORNBUCKLE, WE CHESTNUT, T BALDWIN, BH KORBA, BE TENNANT, BC GERIN, JL PURCELL, RH TI EVIDENCE AGAINST A REQUISITE ROLE FOR DEFECTIVE VIRUS IN THE ESTABLISHMENT OF PERSISTENT HEPADNAVIRUS INFECTIONS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 GEORGETOWN UNIV,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852. CORNELL UNIV,COLL VET MED,ITHACA,NY 14853. RP MILLER, RH (reprint author), NIAID,INFECT DIS LAB,HEPATITIS VIRUSES SECT,BETHESDA,MD 20892, USA. RI Girones, Rosina/B-2975-2009 OI Girones, Rosina/0000-0002-1097-6395 FU NIAID NIH HHS [N01-AI-82698, N01-AI-72623]; PHS HHS [U41-01685-05] NR 29 TC 25 Z9 26 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9329 EP 9332 DI 10.1073/pnas.87.23.9329 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600053 PM 2251274 ER PT J AU PHILLIPS, MA STEWART, BE QIN, Q CHAKRAVARTY, R FLOYD, EE JETTEN, AM RICE, RH AF PHILLIPS, MA STEWART, BE QIN, Q CHAKRAVARTY, R FLOYD, EE JETTEN, AM RICE, RH TI PRIMARY STRUCTURE OF KERATINOCYTE TRANSGLUTAMINASE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 UNIV CALIF DAVIS,DEPT ENVIRONM TOXICOL,DAVIS,CA 95616. UNIV CINCINNATI,MED CTR,DEPT INTERNAL MED,CINCINNATI,OH 45267. NIEHS,PULM PATHOBIOL LAB,RES TRIANGLE PK,NC 27709. OI Jetten, Anton/0000-0003-0954-4445 FU NIAMS NIH HHS [AR 27130] NR 32 TC 131 Z9 133 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9333 EP 9337 DI 10.1073/pnas.87.23.9333 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600054 PM 1979171 ER PT J AU SHIRASAKA, T MURAKAMI, K FORD, H KELLEY, JA YOSHIOKA, H KOJIMA, E AOKI, S BRODER, S MITSUYA, H AF SHIRASAKA, T MURAKAMI, K FORD, H KELLEY, JA YOSHIOKA, H KOJIMA, E AOKI, S BRODER, S MITSUYA, H TI LIPOPHILIC HALOGENATED CONGENERS OF 2',3'-DIDEOXYPURINE NUCLEOSIDES ACTIVE AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS INVITRO SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI,CLIN ONCOL PROGRAM,BETHESDA,MD 20892. SANYO KOKUSAKU PULP CO,PROD TECHNOL RES INST,IWAKUNI,JAPAN. NCI,MED CHEM LAB,BETHESDA,MD 20892. NR 27 TC 61 Z9 62 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9426 EP 9430 DI 10.1073/pnas.87.23.9426 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600073 PM 2251284 ER PT J AU PASCALE, E VALLE, E FURANO, AV AF PASCALE, E VALLE, E FURANO, AV TI AMPLIFICATION OF AN ANCESTRAL MAMMALIAN L1 FAMILY OF LONG INTERSPERSED REPEATED DNA OCCURRED JUST BEFORE THE MURINE RADIATION SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NIDDKD,BIOCHEM PHARMACOL LAB,GENOM STRUCT & FUNCT SECT,BLDG 8,ROOM 203,BETHESDA,MD 20892. NR 25 TC 52 Z9 52 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9481 EP 9485 DI 10.1073/pnas.87.23.9481 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600085 PM 2251288 ER PT J AU CHAUDHARY, VK GALLO, MG FITZGERALD, DJ PASTAN, I AF CHAUDHARY, VK GALLO, MG FITZGERALD, DJ PASTAN, I TI A RECOMBINANT SINGLE-CHAIN IMMUNOTOXIN COMPOSED OF ANTI-TAC VARIABLE REGIONS AND A TRUNCATED DIPHTHERIA-TOXIN SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI,DIV CANC BIOL DIAGNOSIS & CTR,MOLEC BIOL LAB,BETHESDA,MD 20892. NR 24 TC 90 Z9 92 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9491 EP 9494 DI 10.1073/pnas.87.23.9491 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600087 PM 2251289 ER PT J AU MEIKRANTZ, W SUPRYNOWICZ, FA HALLECK, MS SCHLEGEL, RA AF MEIKRANTZ, W SUPRYNOWICZ, FA HALLECK, MS SCHLEGEL, RA TI IDENTIFICATION OF MITOSIS-SPECIFIC P65 DIMER AS A COMPONENT OF HUMAN-PHASE-PROMOTING FACTOR SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 PENN STATE UNIV,DEPT MOLEC & CELL BIOL,UNIVERSITY PK,PA 16802. NCI,BIOCHEM LAB,BETHESDA,MD 20892. NR 34 TC 20 Z9 20 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9600 EP 9604 DI 10.1073/pnas.87.24.9600 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900020 PM 2175907 ER PT J AU PROPST, F ROSENBERG, MP CORK, LC KOVATCH, RM RAUCH, S WESTPHAL, H KHILLAN, J SCHULZ, NT VANDEWOUDE, GF NEWMANN, PE AF PROPST, F ROSENBERG, MP CORK, LC KOVATCH, RM RAUCH, S WESTPHAL, H KHILLAN, J SCHULZ, NT VANDEWOUDE, GF NEWMANN, PE TI NEUROPATHOLOGICAL CHANGES IN TRANSGENIC MICE CARRYING COPIES OF A TRANSCRIPTIONALLY ACTIVATED MOS PROTOONCOGENE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,POB B,FREDERICK,MD 21701. JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205. PATHOL ASSOCIATES INC,FREDERICK,MD 21701. HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,DEPT OTOLARYNGOL,BOSTON,MA 02215. NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. THOMAS JEFFERSON UNIV,PHILADELPHIA,PA 19107. CHILDRENS HOSP MED CTR,BOSTON,MA 02115. FU NCI NIH HHS [N01-CO-74101]; NIGMS NIH HHS [GM20919]; NINDS NIH HHS [NS20820] NR 29 TC 32 Z9 32 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9703 EP 9707 DI 10.1073/pnas.87.24.9703 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900041 PM 1702218 ER PT J AU GUSTAFSSON, K GERMANA, S HIRSCH, F PRATT, K LEGUERN, C SACHS, DH AF GUSTAFSSON, K GERMANA, S HIRSCH, F PRATT, K LEGUERN, C SACHS, DH TI STRUCTURE OF MINIATURE SWINE CLASS-II DRB GENES - CONSERVATION OF HYPERVARIABLE AMINO-ACID-RESIDUES BETWEEN DISTANTLY RELATED MAMMALIAN-SPECIES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI,DIV CANC BIOL & DIAG,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892. NR 31 TC 88 Z9 92 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9798 EP 9802 DI 10.1073/pnas.87.24.9798 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900061 PM 2124703 ER PT J AU ROSENBAUM, LC NEUWELT, EA VANTOL, HHM LOH, YP VERBALIS, JG HELLSTROM, I HELLSTROM, KE NILAVER, G AF ROSENBAUM, LC NEUWELT, EA VANTOL, HHM LOH, YP VERBALIS, JG HELLSTROM, I HELLSTROM, KE NILAVER, G TI EXPRESSION OF NEUROPHYSIN-RELATED PRECURSOR IN CELL-MEMBRANES OF A SMALL-CELL LUNG-CARCINOMA SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 ONCOGEN,SEATTLE,WA 98121. OREGON HLTH SCI UNIV,DEPT BIOCHEM & MOLEC BIOL,PORTLAND,OR 97201. OREGON HLTH SCI UNIV,DEPT CELL BIOL & ANAT,PORTLAND,OR 97201. OREGON HLTH SCI UNIV,DIV NEUROSURG,PORTLAND,OR 97201. OREGON HLTH SCI UNIV,VOLLUM INST ADV BIOMED RES,PORTLAND,OR 97201. VET ADM MED CTR,PORTLAND,OR 97201. NICHHD,DEV NEUROBIOL LAB,CELLULAR NEUROBIOL SECT,BETHESDA,MD 20896. UNIV PITTSBURGH,SCH MED,DEPT MED,PITTSBURGH,PA 15261. RP ROSENBAUM, LC (reprint author), OREGON HLTH SCI UNIV,DEPT NEUROL,PORTLAND,OR 97201, USA. FU NCI NIH HHS [CA-31770]; NIDDK NIH HHS [DK-38094, DK-37205] NR 34 TC 33 Z9 33 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9928 EP 9932 DI 10.1073/pnas.87.24.9928 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900087 PM 1702222 ER PT J AU MILLER, FW WAITE, KA BISWAS, T PLOTZ, PH AF MILLER, FW WAITE, KA BISWAS, T PLOTZ, PH TI THE ROLE OF AN AUTOANTIGEN, HISTIDYL-TRANSFER RNA-SYNTHETASE, IN THE INDUCTION AND MAINTENANCE OF AUTOIMMUNITY SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 DUKE UNIV,SCH MED,DURHAM,NC 27705. NATL INST CHOLERA & ENTER DIS,CALCUTTA,INDIA. RP MILLER, FW (reprint author), NIAMSKD,ARTHRIT & RHEUMAT BRANCH,BETHESDA,MD 20892, USA. OI Miller, Frederick/0000-0003-2831-9593 NR 41 TC 112 Z9 113 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9933 EP 9937 DI 10.1073/pnas.87.24.9933 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900088 PM 1702223 ER PT J AU HOLLSTEIN, MC METCALF, RA WELSH, JA MONTESANO, R HARRIS, CC AF HOLLSTEIN, MC METCALF, RA WELSH, JA MONTESANO, R HARRIS, CC TI FREQUENT MUTATION OF THE P53 GENE IN HUMAN ESOPHAGEAL CANCER SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI, HUMAN CARCINOGENESIS LAB, BLDG 37, ROOM C05, BETHESDA, MD 20892 USA. INT AGCY RES CANC, F-69372 LYON, FRANCE. NR 55 TC 408 Z9 411 U1 0 U2 7 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9958 EP 9961 DI 10.1073/pnas.87.24.9958 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900093 PM 2263646 ER PT J AU HOATLIN, ME KOZAK, SL LILLY, F CHAKRABORTI, A KOZAK, CA KABAT, D AF HOATLIN, ME KOZAK, SL LILLY, F CHAKRABORTI, A KOZAK, CA KABAT, D TI ACTIVATION OF ERYTHROPOIETIN RECEPTORS BY FRIEND VIRAL GP55 AND BY ERYTHROPOIETIN AND DOWN-MODULATION BY THE MURINE FV-2R RESISTANCE GENE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOLEC GENET,BRONX,NY 10461. NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892. RP HOATLIN, ME (reprint author), OREGON HLTH SCI UNIV,DEPT BIOCHEM & MOLEC BIOL,PORTLAND,OR 97201, USA. FU NCI NIH HHS [CA19931, CA25810]; NIAID NIH HHS [AI28572] NR 39 TC 94 Z9 94 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9985 EP 9989 DI 10.1073/pnas.87.24.9985 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900099 PM 2175917 ER PT J AU RUBIN, AL ARNSTEIN, P RUBIN, H AF RUBIN, AL ARNSTEIN, P RUBIN, H TI PHYSIOLOGICAL INDUCTION AND REVERSAL OF FOCUS FORMATION AND TUMORIGENICITY IN NIH-3T3 CELLS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720. NCI,BETHESDA,MD 20892. CALIF DEPT HLTH SERV,BERKELEY,CA 94704. RP RUBIN, AL (reprint author), UNIV CALIF BERKELEY,VIRUS LAB,BERKELEY,CA 94720, USA. FU PHS HHS [15744] NR 21 TC 52 Z9 52 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 10005 EP 10009 DI 10.1073/pnas.87.24.10005 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900103 PM 2263601 ER PT J AU LEVINE, S SALTZMAN, A DEIBLER, GE AF LEVINE, S SALTZMAN, A DEIBLER, GE TI PEPTIDES OF MYELIN BASIC-PROTEIN ARE ENCEPHALITOGENIC IN RATS WITHOUT THE AID OF EMULSIONS SO PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article ID EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; GUINEA-PIG; LEWIS RATS; POSTINFLAMMATORY INCREASE; PERITONEAL-CAVITY; LYMPH-NODES; ABSORPTION; BOVINE; CELLS; PARTICULATE AB Immunization with peptides is usually done with the aid of Freund's adjuvant. Using peptides derived from myelin basic protein, we show that aqueous solutions can be antigenic (encephalitogenic in this instance) in Lewis rats. The first procedure involved multiple doses of aqueous peptide, increased absorption into the lymphatic system from the peritoneal cavity in the postinflammatory state, and the use of pertussis vaccine. Three different peptides containing the major encephalitogenic site were active in this system, with the activity somewhat proportional to the size of the fragment. The second procedure, the direct delivery of peptide to lymph nodes by percutaneous inoculation, was equally successful and did not require the use of pertussis vaccine. C1 NIMH,BETHESDA,MD 20892. RP LEVINE, S (reprint author), NEW YORK MED COLL,DEPT PATHOL,VALHALLA,NY 10595, USA. NR 25 TC 2 Z9 2 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0037-9727 J9 P SOC EXP BIOL MED JI Proc. Soc. Exp. Biol. Med. PD DEC PY 1990 VL 195 IS 3 BP 325 EP 328 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EQ407 UT WOS:A1990EQ40700004 ER PT J AU DAUPHINAIS, D DELISI, LE CROW, TJ ALEXANDROPOULOS, K COLTER, N TUMA, I GERSHON, ES AF DAUPHINAIS, D DELISI, LE CROW, TJ ALEXANDROPOULOS, K COLTER, N TUMA, I GERSHON, ES TI REDUCTION IN TEMPORAL-LOBE SIZE IN SIBLINGS WITH SCHIZOPHRENIA - A MAGNETIC-RESONANCE-IMAGING STUDY SO PSYCHIATRY RESEARCH-NEUROIMAGING LA English DT Article DE SCHIZOPHRENIA; FAMILIAL; MAGNETIC RESONANCE IMAGING ID HIPPOCAMPAL PYRAMIDAL CELL; AFFECTIVE-DISORDER; VENTRICULAR SIZE; CORPUS-CALLOSUM; POSTMORTEM; AREA AB Twenty-eight individuals with familial schizophrenia, from 16 unrelated families (12 sibling pairs and 4 individuals whose siblings refused scanning), and 21 normal control subjects were examined by cerebral magnetic resonance imaging (MRI). Measurements of the cerebrum, temporal lobes, and cerebral lateral ventricles were obtained using consecutive coronal sections containing these structures. Temporal lobe volume was significantly decreased by approximately 10% in these early onset schizophrenic siblings compared with normal controls. These findings add to recent post-mortem and neuroradiological evidence for morphological alteration in the temporal lobes in schizophrenia. C1 NIMH,CLIN NEVROGENET BRANCH,BETHESDA,MD 20892. CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND. NORTHWICK PK HOSP & CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND. RI crow, timothy/M-8327-2014 OI crow, timothy/0000-0002-5482-6655 NR 34 TC 85 Z9 85 U1 1 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0925-4927 J9 PSYCHIAT RES-NEUROIM JI Psychiatry Res. Neuroimaging PD DEC PY 1990 VL 35 IS 2 BP 137 EP 147 PG 11 WC Clinical Neurology; Neuroimaging; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EU286 UT WOS:A1990EU28600004 ER PT J AU CASANOVA, MF STEVENS, JR KLEINMAN, JE AF CASANOVA, MF STEVENS, JR KLEINMAN, JE TI ASTROCYTOSIS IN THE MOLECULAR LAYER OF THE DENTATE GYRUS - A STUDY IN ALZHEIMERS-DISEASE AND SCHIZOPHRENIA SO PSYCHIATRY RESEARCH-NEUROIMAGING LA English DT Review DE SCHIZOPHRENIA; ALZHEIMERS DISEASE; HIPPOCAMPUS; PARAHIPPOCAMPAL GYRUS; ENTORHINAL CORTEX; ASTROCYTES; GRANULE CELL LAYER ID DOPAMINE NERVE-TERMINALS; PERFORANT PATHWAY ZONE; PARAHIPPOCAMPAL GYRUS; ENTORHINAL AREA; FASCIA DENTATA; GRANULOVACUOLAR DEGENERATION; NEUROFIBRILLARY TANGLES; HIPPOCAMPAL-FORMATION; SILVER IMPREGNATION; DORSAL HIPPOCAMPUS AB Recently, several authors have claimed prominent abnormalities in the entorhinal cortex of both patients with Alzheimer's disease (AD) and schizophrenia. The entorhinal cortex is the origin of the perforant pathway, a major input to granule cells of the dentate gyrus of the hippocampus. The present study explored the possibility of a lesion in the entorhinal cortex of both AD and schizophrenic patients by quantiating astrocytic markers within the terminal fields of the perforant pathway. An increase in fibrillary astrocytes was found in half (3/6) of the AD patients while none of the schizophrenic (n = 6) or control (n = 7) brains exhibited gliosis. Since the redistribution and hyperlasia of astrocytes within the molecular layer of the partially deafferented dentate gyrus depend on the chronicity of the entorhinal lesion, the abnormalities observed in AD patients are consistent with the progressive course of the illness. Furthermore, the presence of gliosis in the subiculum of three out of six AD patients suggested pathology secondary to projections from the entorhinal region, amygdala, or prepyriform cortex. The absence of similar changes in schizophrenic patients does not disprove previous claims of entorhinal pathology but suggests that the lesion, if it exists, is either statis in nature or occurred long before death. C1 OREGON HLTH SCI UNIV,PORTLAND,OR 97201. RP CASANOVA, MF (reprint author), ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,CLIN BRAIN DISORDERS BRANCH,BRAIN BANK UNIT,WASHINGTON,DC 20032, USA. NR 104 TC 36 Z9 37 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0925-4927 J9 PSYCHIAT RES-NEUROIM JI Psychiatry Res. Neuroimaging PD DEC PY 1990 VL 35 IS 2 BP 149 EP 166 DI 10.1016/0925-4927(90)90017-Z PG 18 WC Clinical Neurology; Neuroimaging; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EU286 UT WOS:A1990EU28600005 PM 2100806 ER PT J AU ALDER, AG ADAM, J ARENBERG, D AF ALDER, AG ADAM, J ARENBERG, D TI INDIVIDUAL-DIFFERENCES ASSESSMENT OF THE RELATIONSHIP BETWEEN CHANGE IN AND INITIAL LEVEL OF ADULT COGNITIVE-FUNCTIONING SO PSYCHOLOGY AND AGING LA English DT Article C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224. RP ALDER, AG (reprint author), UNIV CALGARY,DEPT PSYCHOL,2500 UNIV DR NW,CALGARY T2N 1N4,ALBERTA,CANADA. NR 44 TC 15 Z9 15 U1 1 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0882-7974 J9 PSYCHOL AGING JI Psychol. Aging PD DEC PY 1990 VL 5 IS 4 BP 560 EP 568 DI 10.1037/0882-7974.5.4.560 PG 9 WC Gerontology; Psychology, Developmental SC Geriatrics & Gerontology; Psychology GA EM364 UT WOS:A1990EM36400012 PM 2278680 ER PT J AU BARR, RA GIAMBRA, LM AF BARR, RA GIAMBRA, LM TI AGE-RELATED DECREMENT IN AUDITORY SELECTIVE ATTENTION SO PSYCHOLOGY AND AGING LA English DT Note C1 NIA,GERONTOL RES CTR,4940 EASTERN AVE,BALTIMORE,MD 21224. NR 9 TC 46 Z9 46 U1 0 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0882-7974 J9 PSYCHOL AGING JI Psychol. Aging PD DEC PY 1990 VL 5 IS 4 BP 597 EP 599 PG 3 WC Gerontology; Psychology, Developmental SC Geriatrics & Gerontology; Psychology GA EM364 UT WOS:A1990EM36400018 PM 2278686 ER PT J AU HIRTLE, PB AF HIRTLE, PB TI GROUP-HEALTH-ASSOCIATION - A PORTRAIT OF A HEALTH MAINTENANCE ORGANIZATION - BERKOWITZ,ED, WOLFF,W SO PUBLIC HISTORIAN LA English DT Book Review RP HIRTLE, PB (reprint author), NATL LIB MED,BETHESDA,MD 20209, USA. OI Hirtle, Peter/0000-0003-3382-5554 NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1990 VL 12 IS 1 BP 112 EP 114 PG 3 WC History SC History GA CY858 UT WOS:A1990CY85800021 ER PT J AU ALGER, JR FRANK, JA BIZZI, A FULHAM, MJ DESOUZA, BX DUHANEY, MO INSCOE, SW BLACK, JL VANZIJL, PCM MOONEN, CTW DICHIRO, G AF ALGER, JR FRANK, JA BIZZI, A FULHAM, MJ DESOUZA, BX DUHANEY, MO INSCOE, SW BLACK, JL VANZIJL, PCM MOONEN, CTW DICHIRO, G TI METABOLISM OF HUMAN GLIOMAS - ASSESSMENT WITH H-1 MR SPECTROSCOPY AND F-18 FLUORODEOXYGLUCOSE PET SO RADIOLOGY LA English DT Article C1 NINCDS,MED NEUROL BRANCH,NEUROIMAGING SECT,BLDG 10,RM 1C-451,BETHESDA,MD 20892. NIH,WARREN G MAGNUSON CLIN CTR,DEPT DIAGNOST RADIOL,BETHESDA,MD 20892. NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892. NCI,DIV CANC TREATMENT,BETHESDA,MD 20892. GEORGETOWN UNIV,DEPT INTERNAL MED,WASHINGTON,DC 20057. GEORGETOWN UNIV,DEPT RADIOL,WASHINGTON,DC 20057. RI van Zijl, Peter/B-8680-2008; Bizzi, Alberto/K-3141-2016; Moonen, Chrit/K-4434-2016 OI Bizzi, Alberto/0000-0002-0253-5274; Moonen, Chrit/0000-0001-5593-3121 NR 56 TC 200 Z9 203 U1 0 U2 3 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD DEC PY 1990 VL 177 IS 3 BP 633 EP 641 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EJ926 UT WOS:A1990EJ92600007 PM 2243962 ER PT J AU LI, ASW CHIGNELL, CF AF LI, ASW CHIGNELL, CF TI STDBII, A DATABASE FOR STORING, RETRIEVING AND ANALYZING SPIN TRAPPING DATA ON AN IBM OR MACINTOSH PERSONAL-COMPUTER SO RESEARCH ON CHEMICAL INTERMEDIATES LA English DT Review RP LI, ASW (reprint author), NIEHS,MOLEC BIOPHYS LAB,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 24 TC 6 Z9 6 U1 0 U2 0 PU VSP BV PI ZEIST PA PO BOX 346, 3700 AH ZEIST, NETHERLANDS SN 0922-6168 J9 RES CHEM INTERMEDIAT JI Res. Chem. Intermed. PD DEC PY 1990 VL 14 IS 3 BP 235 EP 257 PG 23 WC Chemistry, Multidisciplinary SC Chemistry GA EN488 UT WOS:A1990EN48800002 ER PT J AU HOEL, DG AF HOEL, DG TI ASSUMPTIONS OF THE HERP INDEX SO RISK ANALYSIS LA English DT Note RP HOEL, DG (reprint author), NIEHS,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD DEC PY 1990 VL 10 IS 4 BP 623 EP 624 DI 10.1111/j.1539-6924.1990.tb00549.x PG 2 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA EQ606 UT WOS:A1990EQ60600019 PM 2287788 ER PT J AU SMITH, MD BROKER, B MORETTA, L CICCONE, E GROSSI, CE EDWARDS, JCW YUKSEL, F COLACO, B WORMAN, C MACKENZIE, L KINNE, R WESELOH, G GLUCKERT, K LYDYARD, PM AF SMITH, MD BROKER, B MORETTA, L CICCONE, E GROSSI, CE EDWARDS, JCW YUKSEL, F COLACO, B WORMAN, C MACKENZIE, L KINNE, R WESELOH, G GLUCKERT, K LYDYARD, PM TI T-GAMMA-DELTA-CELLS AND THEIR SUBSETS IN BLOOD AND SYNOVIAL TISSUE FROM RHEUMATOID-ARTHRITIS PATIENTS SO SCANDINAVIAN JOURNAL OF IMMUNOLOGY LA English DT Article C1 UNIV COLL & MIDDLESEX SCH MED,DEPT IMMUNOL,ARTHUR STANLEY HOUSE,40-50 TOTTENHAM ST,LONDON W1P 9PG,ENGLAND. UNIV COLL & MIDDLESEX SCH MED,DEPT RHEUMATOL RES,LONDON W1P 9PG,ENGLAND. UNIV COLL & MIDDLESEX SCH MED,DEPT HAEMATOL,LONDON W1P 9PG,ENGLAND. NATL CANC INST,GENOA,ITALY. MAX PLANCK INST IMMUNOL,ERLANGEN,GERMANY. RI Broker, Barbara/O-4850-2015 OI Broker, Barbara/0000-0002-5020-8542 NR 42 TC 69 Z9 69 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0300-9475 J9 SCAND J IMMUNOL JI Scand. J. Immunol. PD DEC PY 1990 VL 32 IS 6 BP 585 EP 593 DI 10.1111/j.1365-3083.1990.tb03200.x PG 9 WC Immunology SC Immunology GA EK254 UT WOS:A1990EK25400003 PM 2148640 ER PT J AU BLAIR, A SARACCI, R STEWART, PA HAYES, RB SHY, C AF BLAIR, A SARACCI, R STEWART, PA HAYES, RB SHY, C TI EPIDEMIOLOGIC EVIDENCE ON THE RELATIONSHIP BETWEEN FORMALDEHYDE EXPOSURE AND CANCER SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH LA English DT Article C1 INT AGCY RES CANC,F-69372 LYONS,FRANCE. RP BLAIR, A (reprint author), NCI,OCCUPAT STUDIES SECT,EXECUT PLAZA N,ROOM 418,BETHESDA,MD 20892, USA. NR 72 TC 89 Z9 90 U1 0 U2 3 PU SCAND J WORK ENV HEALTH PI HELSINKI PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND SN 0355-3140 J9 SCAND J WORK ENV HEA JI Scand. J. Work Environ. Health PD DEC PY 1990 VL 16 IS 6 BP 381 EP 393 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EL766 UT WOS:A1990EL76600001 PM 2284588 ER PT J AU THEODORE, WH AF THEODORE, WH TI EPILEPTIC SEIZURES AND SYNDROMES IN ADULTS SO SEMINARS IN NEUROLOGY LA English DT Article RP THEODORE, WH (reprint author), NINCDS,CLIN EPILEPSY SECT,NIH 10-5,N-248,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0271-8235 J9 SEMIN NEUROL JI Semin. Neurol. PD DEC PY 1990 VL 10 IS 4 BP 389 EP 395 DI 10.1055/s-2008-1063983 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA EN410 UT WOS:A1990EN41000009 PM 2287833 ER PT J AU LONGO, DL AF LONGO, DL TI THE USE OF CHEMOTHERAPY IN THE TREATMENT OF HODGKINS-DISEASE SO SEMINARS IN ONCOLOGY LA English DT Review RP LONGO, DL (reprint author), NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,FREDERICK,MD 21701, USA. NR 143 TC 74 Z9 74 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1990 VL 17 IS 6 BP 716 EP 735 PG 20 WC Oncology SC Oncology GA EM750 UT WOS:A1990EM75000008 PM 2251518 ER PT J AU GILMAN, SL AF GILMAN, SL TI ANTI-SEMITISM AND THE BODY IN PSYCHOANALYSIS SO SOCIAL RESEARCH LA English DT Article C1 NATL LIB MED,BETHESDA,MD 20209. RP GILMAN, SL (reprint author), CORNELL UNIV,HUMANE STUDIES,ITHACA,NY 14853, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU NEW SCH SOC RES PI NEW YORK PA GRADUATE FACULTY 66 W 12TH ST, NEW YORK, NY 10011 SN 0037-783X J9 SOC RES JI Soc. Res. PD WIN PY 1990 VL 57 IS 4 BP 993 EP 1017 PG 25 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA ER644 UT WOS:A1990ER64400009 ER PT J AU SCHOOLER, C AF SCHOOLER, C TI THE INDIVIDUAL IN JAPANESE HISTORY - PARALLELS TO AND DIVERGENCES FROM THE EUROPEAN EXPERIENCE SO SOCIOLOGICAL FORUM LA English DT Article ID BEHAVIOR RP SCHOOLER, C (reprint author), NIMH,SOCIOENVIRONM STUDIES LAB,ROOM B1A-14,FED BLDG,7550 WISCONSIN AVE,BETHESDA,MD 20892, USA. NR 62 TC 7 Z9 7 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0884-8971 J9 SOCIOL FORUM JI Sociol. Forum PD DEC PY 1990 VL 5 IS 4 BP 569 EP 594 DI 10.1007/BF01115392 PG 26 WC Sociology SC Sociology GA EQ159 UT WOS:A1990EQ15900003 ER PT J AU NAM, JM FEARS, TR AF NAM, JM FEARS, TR TI OPTIMUM ALLOCATION OF SAMPLES IN STRATA-MATCHING CASE-CONTROL STUDIES WHEN COST PER SAMPLE DIFFERS FROM STRATUM TO STRATUM SO STATISTICS IN MEDICINE LA English DT Article RP NAM, JM (reprint author), NCI,BIOSTAT BRANCH,ROCKVILLE,MD 20892, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0277-6715 J9 STAT MED JI Stat. Med. PD DEC PY 1990 VL 9 IS 12 BP 1475 EP 1483 DI 10.1002/sim.4780091211 PG 9 WC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Medicine, Research & Experimental; Statistics & Probability SC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Research & Experimental Medicine; Mathematics GA EL211 UT WOS:A1990EL21100008 PM 2281235 ER PT J AU DOHERTY, GM NIEMAN, LK CUTLER, GB CHROUSOS, GP NORTON, JA AF DOHERTY, GM NIEMAN, LK CUTLER, GB CHROUSOS, GP NORTON, JA TI TIME TO RECOVERY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AFTER CURATIVE RESECTION OF ADRENAL-TUMORS IN PATIENTS WITH CUSHINGS-SYNDROME SO SURGERY LA English DT Article; Proceedings Paper CT 11TH ANNUAL MEETING OF THE AMERICAN ASSOC OF ENDOCRINE SURGEONS CY APR 22-24, 1990 CL CLEVELAND, OH SP AMER ASSOC ENDOCRINE SURGEONS C1 NCI,SURG BRANCH,SURG METAB SECT,BLDG 10,ROOM 2B07,BETHESDA,MD 20892. NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NR 12 TC 43 Z9 44 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD DEC PY 1990 VL 108 IS 6 BP 1085 EP 1090 PG 6 WC Surgery SC Surgery GA EL873 UT WOS:A1990EL87300022 PM 2247834 ER PT J AU LANGSTEIN, HN NORTON, JA CHIANG, HCV ODORISIO, TM MATON, PN MARX, SJ JENSEN, RT AF LANGSTEIN, HN NORTON, JA CHIANG, HCV ODORISIO, TM MATON, PN MARX, SJ JENSEN, RT TI THE UTILITY OF CIRCULATING LEVELS OF HUMAN PANCREATIC-POLYPEPTIDE AS A MARKER FOR ISLET CELL TUMORS SO SURGERY LA English DT Article; Proceedings Paper CT 11TH ANNUAL MEETING OF THE AMERICAN ASSOC OF ENDOCRINE SURGEONS CY APR 22-24, 1990 CL CLEVELAND, OH SP AMER ASSOC ENDOCRINE SURGEONS C1 NCI,SURG BRANCH,SURG METAB SECT,BLDG 10,ROOM 2B07,BETHESDA,MD 20892. NIDDKD,DIGEST DIS BRANCH,CELL BIOL SECT,BETHESDA,MD. OHIO STATE UNIV,COLL MED,DIV ENDOCRINOL & METAB,COLUMBUS,OH 43210. NR 20 TC 18 Z9 18 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD DEC PY 1990 VL 108 IS 6 BP 1109 EP 1116 PG 8 WC Surgery SC Surgery GA EL873 UT WOS:A1990EL87300026 PM 2174193 ER PT J AU MILLS, JL AF MILLS, JL TI FERTILITY DRUGS AND NEURAL-TUBE DEFECTS - WHY CANT WE MAKE UP OUR MINDS SO TERATOLOGY LA English DT Letter ID OVULATION; CLOMIPHENE RP MILLS, JL (reprint author), NICHHD,PREVENT RES PROGRAM,BETHESDA,MD 20892, USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0040-3709 J9 TERATOLOGY JI Teratology PD DEC PY 1990 VL 42 IS 6 BP 595 EP 596 DI 10.1002/tera.1420420603 PG 2 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA EP386 UT WOS:A1990EP38600001 PM 2087680 ER PT J AU ABBOTT, BD BIRNBAUM, LS AF ABBOTT, BD BIRNBAUM, LS TI RETINOIC ACID-INDUCED ALTERATIONS IN THE EXPRESSION OF GROWTH-FACTORS IN EMBRYONIC MOUSE PALATAL SHELVES SO TERATOLOGY LA English DT Article ID FACTOR-BETA; FACTOR-ALPHA; DEVELOPMENTAL EXPRESSION; CELL-DIFFERENTIATION; FACTOR-UROGASTRONE; LIMB DEVELOPMENT; FACTOR RECEPTOR; EMBRYOGENESIS; RNA; IDENTIFICATION AB Retinoic acid (RA) is teratogenic in many species, producing multiple malformations, including cleft palate. The effects of RA which lead to cleft palate vary depending on the stage of development exposed. After exposure of embryonic mice to RA on gestation day (GD) 10, abnormally small palatal shelves form. After exposure on GD 12 shelves of normal size form, but fail to fuse, as the medial cells proliferate and differentiate into a nasal-like epithelium. Growth factors and their receptors play an important role in regulating development, and the expression of EGF receptors, EGF, TGF-alpha, TGF-beta-1, and TGF-beta-2 has been reported in the mouse embryo. In a variety of cell types in culture, these growth factors are capable of regulating proliferation, differentiation, expression of matrix proteins, and other cellular events including epithelial-mesenchymal transformations. The present study examines immunohistochemically the expression of EGF, TGF-alpha, TGF-beta-1, and TGF-beta-2 in the control embryonic palatal shelves from GD 12 to 15 and the effects of RA treatment on GD 10 or 12 on their expression on GD 14 and 16. These growth factors were shown to have specific temporal and spatial expression in the palatal shelf. With advancing development the levels of TGF-alpha decreased while the expression of EGF increased. TGF-beta-2 localization became regional by GD 14-15, with higher levels found in epithelial cells and chondrogenic mesenchyme. TGF-beta-1 occurred in epithelial and mesenchymal cells and distribution did not change substantially with advancing development. RA exposure altered the expression of TFG-alpha, TGF-beta-1, and TGF-beta-2, but significant effects on EGF were not found. The effects on TGF-alpha and TGF-beta-1 expression were dependent on the gestational age exposed. Levels of TGF-alpha on GD 14 decreased after RA exposure on GD 10, but increased after GD 12 exposure. TGF-beta-1 expression in the mesenchyme was increased after exposure on GD 12, but was unaffected by RA on GD 10. After exposure on either day, the levels of TGF-beta-2 increased in GD 14 nasal epithelial cells. Acting in concert, growth factors could regulate events critical to formation of the secondary palate, including cessation of medial epithelial cell proliferation, synthesis of extracellular matrix proteins in the mesenchyme, programmed cell death of medial epithelial peridermal cells, and transformation of basal epithelial medial cells to mesenchymal cells. The disruption in growth factor expression occurring after RA exposure appears to be important in the induction of cleft palate and the specific patterns of growth factor expression may determine whether clefting is due to abnormal differentiation of the medial cells and/or to the formation of small shelves. Recent studies in our laboratory show that human palatal shelves express EGF, TGF-alpha, and TGF-beta's in a pattern like that demonstrated for the embryonic mouse shelves. RA is a human teratogen, and cultured human embryonic palatal shelves respond to RA with altered differentiation of the medial cells. The mechanism through which RA induces cleft palate may be similar in mouse and human, and studies of the effects of RA on growth factor expression in the human shelf would provide further evidence of a common mechanism. C1 NIEHS,SYST TOXICOL BRANCH,RES TRIANGLE PK,NC 27709. NR 55 TC 70 Z9 73 U1 0 U2 3 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0040-3709 J9 TERATOLOGY JI Teratology PD DEC PY 1990 VL 42 IS 6 BP 597 EP 610 DI 10.1002/tera.1420420604 PG 14 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA EP386 UT WOS:A1990EP38600002 PM 2087681 ER PT J AU COUTURE, LA ABBOTT, BD BIRNBAUM, LS AF COUTURE, LA ABBOTT, BD BIRNBAUM, LS TI A CRITICAL-REVIEW OF THE DEVELOPMENTAL TOXICITY AND TERATOGENICITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN - RECENT ADVANCES TOWARD UNDERSTANDING THE MECHANISM SO TERATOLOGY LA English DT Article ID HALOGENATED AROMATIC-HYDROCARBONS; NONSENSITIVE MOUSE STRAINS; C57BL/6N MICE; CLEFT-PALATE; CONGENER 3,3',4,4'-TETRACHLOROAZOXYBENZENE; 2,4,5-TRICHLOROPHENOXYACETIC ACID; POLYCHLORINATED DIBENZOFURANS; CELL-DIFFERENTIATION; MATERNAL TOXICITY; FETAL DEVELOPMENT AB A specific teratogenic response is elicited in the mouse as a result of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin). The characteristic spectrum of structural malformations induced in mice following exposure to TCDD and structurally related congeners is highly reproducible and includes both hydronephrosis and cleft palate. In addition, prenatal exposure to TCDD has been shown to induce thymic hypoplasia. These three abnormalities occur at doses well below those producing maternal or embryo/fetal toxicity and are thus among the most sensitive indicators of dioxin toxicity. In all other laboratory species tested, TCDD causes maternal and embryo/fetal toxicity but does not induce a significant increase in the incidence of structural abnormalities even at toxic dose levels. Developmental toxicity occurs in a similar dose range across species; however, mice are particularly susceptible to development of TCDD-induced terata. Recent experiments using an organ culture were an attempt to address the issue of species and organ differences in sensitivity to TCDD. Human palatal shelves examined in th is in vitro system were found to approximate the rate in terms of sensitivity for induction of cleft palate. Investigators have suggested that altered regulation of growth factors and their receptors may involve inappropriate proliferation and differentiation of target cells, ultimately producing TCDD-induced terata. Why the teratogenic effects of TCDD are so highly species and tissue specific, and which animal species most accurately predicts the response of the human embryo/fetus, at the levels of exposure experienced by humans, still remains to be clarified. C1 US EPA,HLTH EFFECTS RES LAB MD66,DIV ENVIRONM TOXICOL,RES TRIANGLE PK,NC 27711. NIEHS,EXPTL TOXICOL BRANCH,RES TRIANGLE PK,NC 27709. UNIV N CAROLINA,CURRICULUM TOXICOL,CHAPEL HILL,NC 27514. US EPA,DIV DEV TOXICOL,RES TRIANGLE PK,NC 27711. NR 72 TC 193 Z9 197 U1 1 U2 9 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0040-3709 J9 TERATOLOGY JI Teratology PD DEC PY 1990 VL 42 IS 6 BP 619 EP 627 DI 10.1002/tera.1420420606 PG 9 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA EP386 UT WOS:A1990EP38600004 PM 2087682 ER PT J AU MEDINSKY, MA BECHTOLD, WE BIRNBAUM, LS HENDERSON, RF AF MEDINSKY, MA BECHTOLD, WE BIRNBAUM, LS HENDERSON, RF TI MEASUREMENT OF STEADY-STATE BLOOD-CONCENTRATIONS IN B6C3F1 MICE EXPOSED BY INHALATION TO VINYLIDENE FLUORIDE SO TOXICOLOGY LA English DT Article C1 LOVELACE INHALAT TOXICOL RES INST,INHALAT TOXICOL RES INST,POB 5890,ALBUQUERQUE,NM 87185. NIEHS,RES TRIANGLE PK,NC 27709. FU NIEHS NIH HHS [222-Y02-ES-20092] NR 9 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD DEC PY 1990 VL 64 IS 3 BP 255 EP 263 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EM948 UT WOS:A1990EM94800004 PM 2267664 ER PT J AU ABBOTT, BD BIRNBAUM, LS AF ABBOTT, BD BIRNBAUM, LS TI TCDD-INDUCED ALTERED EXPRESSION OF GROWTH-FACTORS MAY HAVE A ROLE IN PRODUCING CLEFT-PALATE AND ENHANCING THE INCIDENCE OF CLEFTS AFTER COADMINISTRATION OF RETINOIC ACID AND TCDD SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID EPITHELIAL-CELL DIFFERENTIATION; FACTOR-BETA; DEVELOPMENTAL EXPRESSION; FACTOR-ALPHA; AH RECEPTOR; MOUSE; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; TOXICITY; RNA; PALATOGENESIS C1 NIEHS,NATL TOXICOL PROGRAM,RES TRIANGLE PK,NC 27709. NR 38 TC 95 Z9 96 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD DEC PY 1990 VL 106 IS 3 BP 418 EP 432 DI 10.1016/0041-008X(90)90337-T PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EQ026 UT WOS:A1990EQ02600005 PM 2260090 ER PT J AU DIETER, MP BOORMAN, GA JAMESON, CW MATTHEWS, HB HUFF, JE AF DIETER, MP BOORMAN, GA JAMESON, CW MATTHEWS, HB HUFF, JE TI THE CARCINOGENIC ACTIVITY OF COMMERCIAL GRADE TOLUENE DIISOCYANATE IN RATS AND MICE IN RELATION TO THE METABOLISM OF THE 2,4-TDI AND 2,6-TDI ISOMERS SO TOXICOLOGY AND INDUSTRIAL HEALTH LA English DT Article DE 2,4(80-PERCENT)- AND 2,6(20-PERCENT) TOLUENE DIISOCYANATE; COMMERCIAL GRADE; TDI; POLYURETHANE FOAM POLYMERIZER; RODENTS; INHALATION TOXICITY; CARCINOGENICITY ID INHALATION CHALLENGE; F344/N RATS; GUINEA-PIGS; TDI; WORKERS; HYPERSENSITIVITY; PANCREAS; EXPOSURE; TESTS AB Groups of 50 F344\N rats of each sex and 50 B6C3F1 mice of each sex were gavaged with corn oil or a mixture of toluene diisocyanate (TDI) in corn oil for 5 days per week for 105 or 106 weeks. Female rats and mice were given doses of 60 or 120 mg/kg body weight, while male rats received 30 or 60 mg/kg, and male mice received 120 or 240 mg/kg. The TDI reacted with the moisture in the corn oil vehicle resulting in doses that were 10% to 23% below the target dose concentrations. The chemical product used was commercial grade TDI, which was an 80%-20% mixture of the 2,4- and 2,6-isomers. Chemical disposition and metabolism studies were conducted with each of the radiolabelled TDI isomers in male rats. Absorption of both of the TDI isomers occurred, with the highest concentrations found in the stomach, cecum, large intestine, and bladder. Excretion occurred via the feces and urine. The major metabolic products from the metabolism of 2,4-TDI were shown to be identical with those from the metabolism of the carcinogen, 2,4-diaminotoluene, whereas the metabolism of the 2,6-TDI isomer yielded one major product, identified as 2,6-bis(acetylamino)toluene. Greater than 10% depression in body weight gain occurred in all dosed groups of rats throughout most of the study. The major non-neoplastic lesions that were observed in both sexes of the TDI-exposed rats were dose-related increases in acute bronchopneumonia, characterized as chemical pneumonitis, with incidences as high as 50%. In mice mean body weight gain was depressed in dosed male and in high dose females. The principle non-neoplastic lesion in mice that was attributed to chemical treatment was cytomegaly of the kidney tubular epithelium in males. Survival in all groups of dosed rats was significantly lower than in controls. A dose-dependent pattern of mortality did not commence until 70 weeks of exposure, demonstrating that toluene diisocyanate elicited a cumulative toxic response. There was also significantly lower survival in high dose male, but not female mice, by comparison to controls. Despite the reduction of power and sensitivity in the rat studies caused by early mortality, statistically significant increases in tumor incidences were observed in many different target organs. TDI was carcinogenic in F344\N rats, causing subcutaneous fibromas and fibrosarcomas in males and females, pancreatic acinar cell adenomas in males, and pancreatic islet cell adenomas, neoplastic nodules of the liver, and mammary gland tumors in females. TDI was not carcinogenic in male mice, but caused hemangiomas or hemangiosarcomas and hepatocellular adenomas in female B6C3F1 mice. The pattern of multiple tumor induction caused by administration of the commercial grade TDI was very similar to that found in previous studies of the carcinogen, 2,4-diaminotoluene. The specific target sites of carcinogenicity in the 2,4-diaminotoluene study were all seen in the 2,4-(80%) and 2,6-(20%) TDI study as well. Metabolic studies of these compounds showed that common metabolites were produced from the 2,4-TDI isomer and from 2,4-diaminotoluene, indicating that the 2,4-isomer in the commercial grade TDI was probably responsible for the carcinogenic activity. RP DIETER, MP (reprint author), NIEHS,NATL TOXICOL PROGRAM,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 58 TC 11 Z9 12 U1 0 U2 4 PU PRINCETON SCIENTIFIC PUBL INC PI PRINCETON PA PO BOX 2155, PRINCETON, NJ 08543 SN 0748-2337 J9 TOXICOL IND HEALTH JI Toxicol. Ind. Health PD DEC PY 1990 VL 6 IS 6 BP 599 EP 621 PG 23 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA EZ231 UT WOS:A1990EZ23100005 PM 1965872 ER PT J AU KUHAR, MJ AF KUHAR, MJ TI A GABA TRANSPORTER CDNA HAS BEEN CLONED SO TRENDS IN NEUROSCIENCES LA English DT Editorial Material RP KUHAR, MJ (reprint author), NIDA,ADDICT RES CTR,NEUROSCI BRANCH,POB 5180,BALTIMORE,MD 21224, USA. 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NR 39 TC 28 Z9 28 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 1990 VL 179 IS 2 BP 632 EP 639 DI 10.1016/0042-6822(90)90130-J PG 8 WC Virology SC Virology GA EK040 UT WOS:A1990EK04000008 PM 2173256 ER PT J AU ASSOULINE, JG LEVIN, MJ MAJOR, EO FORGHANI, B STRAUS, SE OSTROVE, JM AF ASSOULINE, JG LEVIN, MJ MAJOR, EO FORGHANI, B STRAUS, SE OSTROVE, JM TI VARICELLA-ZOSTER VIRUS-INFECTION OF HUMAN ASTROCYTES, SCHWANN-CELLS, AND NEURONS SO VIROLOGY LA English DT Article C1 NINCDS,VIRAL & MOLEC PATHOGENESIS LAB,MOLEC VIROL & GENET SECT,BLDG 36,BETHESDA,MD 20892. NIAID,CLIN INVEST LAB,VIRAL & RICKETTSIAL DIS LAB,BETHESDA,MD 20892. FU NIA NIH HHS [P01AGNS07347-03] NR 39 TC 18 Z9 18 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 1990 VL 179 IS 2 BP 834 EP 844 DI 10.1016/0042-6822(90)90152-H PG 11 WC Virology SC Virology GA EK040 UT WOS:A1990EK04000030 PM 2173263 ER PT J AU SHIH, C YU, MYW LI, LS SHIH, JWK AF SHIH, C YU, MYW LI, LS SHIH, JWK TI HEPATITIS-B VIRUS PROPAGATED IN A RAT HEPATOMA-CELL LINE IS INFECTIOUS IN A PRIMATE MODEL SO VIROLOGY LA English DT Note C1 NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT TRANSFUS MED,BETHESDA,MD 20892. UNIV PENN,SCH MED,DEPT BIOCHEM & BIOPHYS,PHILADELPHIA,PA 19104. US FDA,CTR BIOL EVALUAT & RES,DIV BLOOD & BLOOD PROD,BETHESDA,MD 20205. 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PD NOV 25 PY 1990 VL 265 IS 33 BP 20646 EP 20652 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ525 UT WOS:A1990EJ52500090 PM 2243110 ER PT J AU OGATA, M CHAUDHARY, VK PASTAN, I FITZGERALD, DJ AF OGATA, M CHAUDHARY, VK PASTAN, I FITZGERALD, DJ TI PROCESSING OF PSEUDOMONAS EXOTOXIN BY A CELLULAR PROTEASE RESULTS IN THE GENERATION OF A 37,000-DA TOXIN FRAGMENT THAT IS TRANSLOCATED TO THE CYTOSOL SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP OGATA, M (reprint author), NCI,MOLEC BIOL LAB,BETHESDA,MD 20892, USA. NR 41 TC 212 Z9 213 U1 0 U2 5 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 25 PY 1990 VL 265 IS 33 BP 20678 EP 20685 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ525 UT WOS:A1990EJ52500095 PM 2122978 ER PT J AU NASHED, EM PERDOMO, GR PADLAN, EA KOVAC, P MATSUDA, T KABAT, EA GLAUDEMANS, CPJ AF NASHED, EM PERDOMO, GR PADLAN, EA KOVAC, P MATSUDA, T KABAT, EA GLAUDEMANS, CPJ TI BINDING CHARACTERISTICS OF IGA-16.4.12E, A MONOCLONAL-ANTIBODY WITH SPECIFICITY FOR THE NONREDUCING TERMINAL EPITOPE OF ALPHA-(1-]6)-DEXTRANS - COMPARISONS BETWEEN IGA HYBRIDOMA-16.4.12E AND MYELOMA-W3129 SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NIDDKD, BETHESDA, MD 20892 USA. NIH, OFF DIRECTOR, BETHESDA, MD 20892 USA. COLUMBIA UNIV COLL PHYS & SURG, DEPT MICROBIOL, NEW YORK, NY 10032 USA. COLUMBIA UNIV COLL PHYS & SURG, DEPT GENET & DEV, NEW YORK, NY 10032 USA. FU PHS HHS [1R01 A1-19042] NR 58 TC 36 Z9 36 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 25 PY 1990 VL 265 IS 33 BP 20699 EP 20707 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ525 UT WOS:A1990EJ52500098 PM 1700793 ER PT J AU CAPRANICO, G KOHN, KW POMMIER, Y AF CAPRANICO, G KOHN, KW POMMIER, Y TI LOCAL SEQUENCE REQUIREMENTS FOR DNA CLEAVAGE BY MAMMALIAN TOPOISOMERASE-II IN THE PRESENCE OF DOXORUBICIN SO NUCLEIC ACIDS RESEARCH LA English DT Article C1 NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,BETHESDA,MD 20892. RI Capranico, Giovanni/K-1678-2014 OI Capranico, Giovanni/0000-0002-8708-6454 NR 29 TC 175 Z9 175 U1 0 U2 2 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD NOV 25 PY 1990 VL 18 IS 22 BP 6611 EP 6619 DI 10.1093/nar/18.22.6611 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EK586 UT WOS:A1990EK58600021 PM 2174543 ER PT J AU DIAMOND, AM MONTEROPUERNER, Y LEE, BJ HATFIELD, D AF DIAMOND, AM MONTEROPUERNER, Y LEE, BJ HATFIELD, D TI SELENOCYSTEINE INSERTING TRANSFER-RNAS ARE LIKELY GENERATED BY TRANSFER-RNA EDITING SO NUCLEIC ACIDS RESEARCH LA English DT Note C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. RP DIAMOND, AM (reprint author), UNIV CHICAGO,DEPT RADIAT & CELLULAR ONCOL,CHICAGO,IL 60639, USA. NR 7 TC 35 Z9 35 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD NOV 25 PY 1990 VL 18 IS 22 BP 6727 EP 6727 DI 10.1093/nar/18.22.6727 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EK586 UT WOS:A1990EK58600074 PM 2251154 ER PT J AU TORRENCE, PF KOVACS, T AF TORRENCE, PF KOVACS, T TI A SWIFT AND FACILE RADIOSYNTHESIS OF [ALPHA-P-32]-3'-AZIDO-3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE (AZT TRIPHOSPHATE) SO NUCLEIC ACIDS RESEARCH LA English DT Note RP TORRENCE, PF (reprint author), NIDDKD,MED CHEM LAB,BIOMED CHEM SECT,BETHESDA,MD 20892, USA. NR 9 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD NOV 25 PY 1990 VL 18 IS 22 BP 6738 EP 6738 DI 10.1093/nar/18.22.6738 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EK586 UT WOS:A1990EK58600082 PM 2251159 ER PT J AU MILMAN, G AF MILMAN, G TI HIV RESEARCH IN THE SCID MOUSE - BIOSAFETY CONSIDERATIONS SO SCIENCE LA English DT Article RP MILMAN, G (reprint author), NIAID,BETHESDA,MD 20892, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 23 PY 1990 VL 250 IS 4984 BP 1152 EP 1152 DI 10.1126/science.2251504 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ581 UT WOS:A1990EJ58100041 PM 2251504 ER PT J AU LUSSO, P VERONESE, FD ENSOLI, B FRANCHINI, G JEMMA, C DEROCCO, SE KALYANARAMAN, VS GALLO, RC AF LUSSO, P VERONESE, FD ENSOLI, B FRANCHINI, G JEMMA, C DEROCCO, SE KALYANARAMAN, VS GALLO, RC TI PSEUDOTYPES IN HIV-INFECTED MICE - REPLY SO SCIENCE LA English DT Article C1 BIONET RES LABS INC,DEPT CELL BIOL,KENSINGTON,MD 20852. UNIV TURIN,INST MICROBIOL,I-10124 TURIN,ITALY. RP LUSSO, P (reprint author), NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892, USA. RI Ensoli, Barbara/J-9169-2016 OI Ensoli, Barbara/0000-0002-0545-8737 NR 9 TC 1 Z9 1 U1 0 U2 1 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 23 PY 1990 VL 250 IS 4984 BP 1153 EP 1154 DI 10.1126/science.250.4984.1153 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ581 UT WOS:A1990EJ58100043 PM 17840195 ER PT J AU MASUR, H AF MASUR, H TI CONSENSUS STATEMENT ON THE USE OF CORTICOSTEROIDS AS ADJUNCTIVE THERAPY FOR PNEUMOCYSTIS PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material RP MASUR, H (reprint author), NIH,CTR CLIN 10048,BETHESDA,MD 20892, USA. NR 25 TC 124 Z9 126 U1 1 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 22 PY 1990 VL 323 IS 21 BP 1500 EP 1504 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EJ407 UT WOS:A1990EJ40700033 ER PT J AU DAVIS, DL HOEL, D FOX, J LOPEZ, AD AF DAVIS, DL HOEL, D FOX, J LOPEZ, AD TI INTERNATIONAL TRENDS IN CANCER MORTALITY IN FRANCE, WEST-GERMANY, ITALY, JAPAN, ENGLAND AND WALES, AND THE UNITED-STATES SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID MULTIPLE-MYELOMA; DEATH; WOMEN; MEN C1 NATL RES COUNCIL,WASHINGTON,DC 20418. NIEHS,RES TRIANGLE PK,NC 27709. OFF POPULAT CENSUSES & SURVEYS,LONDON,ENGLAND. GLOBAL HLTH SITUAT ASSESSMENT & PROJECT UNIT,GENEVA,SWITZERLAND. WHO,GENEVA,SWITZERLAND. RI Lopez, Alan/F-1487-2010 OI Lopez, Alan/0000-0001-5818-6512 NR 46 TC 25 Z9 25 U1 0 U2 2 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 5 EP 48 DI 10.1111/j.1749-6632.1990.tb32055.x PG 44 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300001 PM 2264657 ER PT J AU PERCY, CL MILLER, BA RIES, LAG AF PERCY, CL MILLER, BA RIES, LAG TI EFFECT OF CHANGES IN CANCER CLASSIFICATION AND THE ACCURACY OF CANCER DEATH CERTIFICATES ON TRENDS IN CANCER MORTALITY SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 NCI,DIV CANC PREVENT & CONTROL,SURVEILLANCE PROGRAM,CANC STAT BRANCH,BETHESDA,MD 20892. RP PERCY, CL (reprint author), NCI,CANC SURVEILLANCE BRANCH,EXECUTIVE PLAZA N,ROOM 343 J,BETHESDA,MD 20892, USA. NR 6 TC 83 Z9 84 U1 0 U2 1 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 87 EP 99 DI 10.1111/j.1749-6632.1990.tb32059.x PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300005 PM 2264660 ER PT J AU JABLON, S THOMPSON, D MCCONNEY, M MABUCHI, K AF JABLON, S THOMPSON, D MCCONNEY, M MABUCHI, K TI ACCURACY OF CAUSE-OF-DEATH CERTIFICATION IN HIROSHIMA AND NAGASAKI, JAPAN SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 RADIAT EFFECTS RES FDN,HIROSHIMA 733,JAPAN. RP JABLON, S (reprint author), NCI,RADIAT EPIDEMIOL BRANCH,6130 EXECUTIVE PLAZA N,ROOM 408,BETHESDA,MD 20892, USA. NR 7 TC 8 Z9 8 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 100 EP 109 DI 10.1111/j.1749-6632.1990.tb32060.x PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300006 PM 2264636 ER PT J AU DAVIS, DL HOEL, D PERCY, C AHLBOM, A SCHWARTZ, J AF DAVIS, DL HOEL, D PERCY, C AHLBOM, A SCHWARTZ, J TI IS BRAIN CANCER MORTALITY INCREASING IN INDUSTRIAL-COUNTRIES SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID TRENDS C1 NIEHS,NATL TOXICOL PROGRAM,RES TRIANGLE PK,NC 27709. NCI CANC SURVEILLANCE BRANCH,ROCKVILLE,MD 20892. KAROLINSKA INST,STOCKHOLM 18,SWEDEN. US EPA,WASHINGTON,DC 20460. RP DAVIS, DL (reprint author), NATL ACAD SCI,2101 CONSTITUT AVE NW,WASHINGTON,DC 20418, USA. NR 11 TC 18 Z9 19 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 191 EP 204 DI 10.1111/j.1749-6632.1990.tb32067.x PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300013 PM 2264643 ER PT J AU MALKER, HSR WEINER, JA MCLAUGHLIN, JK AF MALKER, HSR WEINER, JA MCLAUGHLIN, JK TI REGISTER EPIDEMIOLOGY STUDIES OF RECENT CANCER TRENDS IN SELECTED WORKERS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID SWEDEN C1 NCI,BETHESDA,MD 20892. RP MALKER, HSR (reprint author), NATL BOARD OCCUPAT SAFETY & HLTH,S-17184 SOLNA,SWEDEN. NR 17 TC 6 Z9 6 U1 1 U2 1 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 322 EP 333 DI 10.1111/j.1749-6632.1990.tb32079.x PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300025 PM 2264654 ER PT J AU DAVIS, DL HOEL, D AF DAVIS, DL HOEL, D TI PLANS FOR DATA-BASE DEVELOPMENT NETWORK - CONCLUDING DISCUSSION SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Discussion C1 NIEHS,RES TRIANGLE PK,NC 27709. RP DAVIS, DL (reprint author), NATL ACAD SCI,2101 CONSTITUT AVE,WASHINGTON,DC 20418, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 21 PY 1990 VL 609 BP 340 EP 345 DI 10.1111/j.1749-6632.1990.tb32081.x PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA623 UT WOS:A1990FA62300027 ER PT J AU REGIER, DA FARMER, ME RAE, DS LOCKE, BZ KEITH, SJ JUDD, LL GOODWIN, FK AF REGIER, DA FARMER, ME RAE, DS LOCKE, BZ KEITH, SJ JUDD, LL GOODWIN, FK TI COMORBIDITY OF MENTAL-DISORDERS WITH ALCOHOL AND OTHER DRUG-ABUSE - RESULTS FROM THE EPIDEMIOLOGIC CATCHMENT-AREA (ECA) STUDY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article C1 NIMH,EPIDEMIOL & PSYCHOPATHOL RES BRANCH,ROCKVILLE,MD 20857. RP REGIER, DA (reprint author), NIMH,DIV CLIN RES,OFF DIRECTOR,5600 FISHERS LN,ROOM 10-105,ROCKVILLE,MD 20857, USA. FU NIMH NIH HHS [U01 MH 34224, U01 MH 33870, U01 MH 33883] NR 55 TC 2526 Z9 2562 U1 32 U2 155 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 21 PY 1990 VL 264 IS 19 BP 2511 EP 2518 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA EH795 UT WOS:A1990EH79500027 PM 2232018 ER PT J AU IKURA, M BAX, A CLORE, GM GRONENBORN, AM AF IKURA, M BAX, A CLORE, GM GRONENBORN, AM TI DETECTION OF NUCLEAR OVERHAUSER EFFECTS BETWEEN DEGENERATE AMIDE PROTON RESONANCES BY HETERONUCLEAR 3-DIMENSIONAL NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Note C1 NIDDKD,CHEM PHYS LAB,BLDG 2,BETHESDA,MD 20892. RI Clore, G. Marius/A-3511-2008 OI Clore, G. Marius/0000-0003-3809-1027 NR 26 TC 163 Z9 163 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD NOV 21 PY 1990 VL 112 IS 24 BP 9020 EP 9022 DI 10.1021/ja00180a080 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA EJ956 UT WOS:A1990EJ95600080 ER PT J AU SCHATZKIN, A FREEDMAN, LS SCHIFFMAN, MH DAWSEY, SM AF SCHATZKIN, A FREEDMAN, LS SCHIFFMAN, MH DAWSEY, SM TI VALIDATION OF INTERMEDIATE END-POINTS IN CANCER-RESEARCH SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Editorial Material C1 NCI,DIV CANC ETIOL,BETHESDA,MD 20892. RP SCHATZKIN, A (reprint author), NCI,DIV CANC PREVENT & CONTROL,EXECUT PLAZA N,ROOM 211,BETHESDA,MD 20892, USA. NR 25 TC 113 Z9 114 U1 0 U2 4 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD NOV 21 PY 1990 VL 82 IS 22 BP 1746 EP 1752 DI 10.1093/jnci/82.22.1746 PG 7 WC Oncology SC Oncology GA EJ536 UT WOS:A1990EJ53600009 PM 2231769 ER PT J AU MCMAHON, J SCHMID, S WEISLOW, O STINSON, S CAMALIER, R GULAKOWSKI, R SHOEMAKER, R KISER, R DYKES, D HARRISON, S MAYO, J BOYD, M AF MCMAHON, J SCHMID, S WEISLOW, O STINSON, S CAMALIER, R GULAKOWSKI, R SHOEMAKER, R KISER, R DYKES, D HARRISON, S MAYO, J BOYD, M TI FEASIBILITY OF CELLULAR MICROENCAPSULATION TECHNOLOGY FOR EVALUATION OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS DRUGS INVIVO SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article C1 SO RES INST,BIRMINGHAM,AL 35255. PROGRAM RESOURCES INC,FREDERICK,MD. RP MCMAHON, J (reprint author), NCI,FREDERICK CANC RES & DEV CTR,DEV THERAPEUT PROGRAM,FREDERICK,MD 21701, USA. FU NCI NIH HHS [N01-CO7410] NR 18 TC 11 Z9 11 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD NOV 21 PY 1990 VL 82 IS 22 BP 1761 EP 1765 DI 10.1093/jnci/82.22.1761 PG 5 WC Oncology SC Oncology GA EJ536 UT WOS:A1990EJ53600012 PM 2231771 ER PT J AU KRUEGER, GRF WASSERMANN, K DECLERCK, LS STEVENS, WJ BOURGEOIS, N ABLASHI, DV JOSEPHS, SF BALACHANDRAN, N AF KRUEGER, GRF WASSERMANN, K DECLERCK, LS STEVENS, WJ BOURGEOIS, N ABLASHI, DV JOSEPHS, SF BALACHANDRAN, N TI LATENT HERPESVIRUS-6 IN SALIVARY AND BRONCHIAL GLANDS SO LANCET LA English DT Letter C1 UNIV COLOGNE,MED CLIN 3,W-5000 COLOGNE 41,GERMANY. UNIV KANSAS,DEPT MICROBIOL,LAWRENCE,KS 66045. NCI,BETHESDA,MD 20892. UNIV INSTELLING ANTWERP,DEPT IMMUNOL,B-2610 WILRIJK,BELGIUM. UNIV INSTELLING ANTWERP,DEPT PATHOL,B-2610 WILRIJK,BELGIUM. RP KRUEGER, GRF (reprint author), UNIV COLOGNE,INST PATHOL,IMMUNOPATHOL LAB,W-5000 COLOGNE 41,GERMANY. NR 6 TC 68 Z9 70 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD NOV 17 PY 1990 VL 336 IS 8725 BP 1255 EP 1256 DI 10.1016/0140-6736(90)92874-H PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EJ064 UT WOS:A1990EJ06400041 PM 1978098 ER PT J AU DAVIS, DL HOEL, D FOX, J LOPEZ, A AF DAVIS, DL HOEL, D FOX, J LOPEZ, A TI TRENDS IN CANCER MORTALITY - REPLY SO LANCET LA English DT Letter C1 NIEHS,RES TRIANGLE PK,NC 27709. WHO,GLOBAL HLTH SITUAT ASSESSMENT & PROJECT UNIT,CH-1211 GENEVA 27,SWITZERLAND. RP DAVIS, DL (reprint author), NATL ACAD SCI,NATL RES COUNCIL,WASHINGTON,DC 20418, USA. RI Lopez, Alan/F-1487-2010 OI Lopez, Alan/0000-0001-5818-6512 NR 8 TC 0 Z9 0 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD NOV 17 PY 1990 VL 336 IS 8725 BP 1264 EP 1265 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EJ064 UT WOS:A1990EJ06400057 ER PT J AU BALLESTER, R MARCHUK, D BOGUSKI, M SAULINO, A LETCHER, R WIGLER, M COLLINS, F AF BALLESTER, R MARCHUK, D BOGUSKI, M SAULINO, A LETCHER, R WIGLER, M COLLINS, F TI THE NF1 LOCUS ENCODES A PROTEIN FUNCTIONALLY RELATED TO MAMMALIAN GAP AND YEAST IRA PROTEINS SO CELL LA English DT Article C1 UNIV MICHIGAN,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109. UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109. UNIV MICHIGAN,DEPT HUMAN GENET,ANN ARBOR,MI 48109. NIH,NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894. RP BALLESTER, R (reprint author), COLD SPRING HARBOR LAB,COLD SPRING HARBOR,NY 11724, USA. 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PD NOV 16 PY 1990 VL 532 IS 2 BP 442 EP 444 DI 10.1016/S0378-4347(00)83797-4 PG 3 WC Chemistry, Analytical SC Chemistry GA EL790 UT WOS:A1990EL79000026 PM 1964692 ER PT J AU BROWN, PS ROBERTS, CS MCINTOSH, CL ROBERTS, WC CLARK, RE AF BROWN, PS ROBERTS, CS MCINTOSH, CL ROBERTS, WC CLARK, RE TI COMBINED OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY AND STENOTIC CONGENITALLY BICUSPID AORTIC-VALVE SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Note C1 NHLBI,PATHOL BRANCH,BETHESDA,MD 20892. RP BROWN, PS (reprint author), NHLBI,SURG BRANCH,ROOM 2N244,BLDG 10,BETHESDA,MD 20892, USA. NR 6 TC 3 Z9 3 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD NOV 15 PY 1990 VL 66 IS 17 BP 1273 EP 1275 DI 10.1016/0002-9149(90)91120-U PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EH711 UT WOS:A1990EH71100031 PM 2239738 ER PT J AU RODRIGUES, MM KRUTH, HS KRACHMER, JH VRABEC, MP BLANCHETTEMACKIE, J AF RODRIGUES, MM KRUTH, HS KRACHMER, JH VRABEC, MP BLANCHETTEMACKIE, J TI CHOLESTEROL LOCALIZATION IN ULTRATHIN FROZEN-SECTIONS IN SCHNYDERS CORNEAL CRYSTALLINE DYSTROPHY SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article C1 UNIV IOWA,IOWA LIONS CORNEA CTR,IOWA CITY,IA 52242. NHLBI,BETHESDA,MD 20892. NIADDKD,BETHESDA,MD 20892. UNIV MARYLAND,DEPT OPHTHALMOL,OPHTHALM PATHOL LAB,BALTIMORE,MD 21201. NR 15 TC 13 Z9 13 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD NOV 15 PY 1990 VL 110 IS 5 BP 513 EP 517 PG 5 WC Ophthalmology SC Ophthalmology GA EG045 UT WOS:A1990EG04500005 PM 2240137 ER PT J AU FALES, HM SOKOLOSKI, EA PANNELL, LK PU, QL KLAYMAN, DL LIN, AJ BROSSI, A KELLEY, JA AF FALES, HM SOKOLOSKI, EA PANNELL, LK PU, QL KLAYMAN, DL LIN, AJ BROSSI, A KELLEY, JA TI COMPARISON OF MASS-SPECTRAL TECHNIQUES USING ORGANIC PEROXIDES RELATED TO ARTEMISININ SO ANALYTICAL CHEMISTRY LA English DT Article C1 NIDDKD,BIOORGAN CHEM,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NIDDKD,CHEM LAB,BETHESDA,MD 20892. NCI,MED CHEM LAB,BETHESDA,MD 20892. RP FALES, HM (reprint author), NHLBI,BIOPHYS CHEM LAB,BETHESDA,MD 20892, USA. NR 22 TC 20 Z9 21 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD NOV 15 PY 1990 VL 62 IS 22 BP 2494 EP 2501 DI 10.1021/ac00221a016 PG 8 WC Chemistry, Analytical SC Chemistry GA EH237 UT WOS:A1990EH23700018 PM 2270868 ER PT J AU HENDERSON, DK FAHEY, BJ WILLY, M SCHMITT, JM CAREY, K KOZIOL, DE LANE, HC FEDIO, J SAAH, AJ AF HENDERSON, DK FAHEY, BJ WILLY, M SCHMITT, JM CAREY, K KOZIOL, DE LANE, HC FEDIO, J SAAH, AJ TI RISK FOR OCCUPATIONAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) ASSOCIATED WITH CLINICAL-EXPOSURES - A PROSPECTIVE EVALUATION SO ANNALS OF INTERNAL MEDICINE LA English DT Article C1 NIH,CTR CLIN,BETHESDA,MD 20892. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21218. RP HENDERSON, DK (reprint author), NIAID,BLDG 10,ROOM 2C146,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 34 TC 331 Z9 331 U1 0 U2 3 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1990 VL 113 IS 10 BP 740 EP 746 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA EH363 UT WOS:A1990EH36300004 PM 2240876 ER PT J AU STEVENSON, H GAZDAR, AF PHELPS, R LINNOILA, RI IHDE, DC GHOSH, B WALSH, T WOODS, EL OIE, H OCONNOR, T MAKUCH, R KRAMER, BS MULSHINE, JL AF STEVENSON, H GAZDAR, AF PHELPS, R LINNOILA, RI IHDE, DC GHOSH, B WALSH, T WOODS, EL OIE, H OCONNOR, T MAKUCH, R KRAMER, BS MULSHINE, JL TI TUMOR-CELL LINES ESTABLISHED INVITRO - AN INDEPENDENT PROGNOSTIC FACTOR FOR SURVIVAL IN NON-SMALL-CELL LUNG-CANCER SO ANNALS OF INTERNAL MEDICINE LA English DT Article C1 NATL NAVAL MED CTR, NCI,MED ONCOL BRANCH,BIOTHERAPY SECT,BLDG 8, ROOM 5101, BETHESDA, MD 20814 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. YALE UNIV, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06510 USA. NR 38 TC 47 Z9 47 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1990 VL 113 IS 10 BP 764 EP 770 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA EH363 UT WOS:A1990EH36300008 PM 1700655 ER PT J AU SABOL, SL HIGUCHI, H AF SABOL, SL HIGUCHI, H TI REGULATION OF NEUROPEPTIDE-Y TRANSCRIPTION AND MESSENGER-RNA LEVELS BY NERVE GROWTH-FACTOR, GLUCOCORTICOIDS, CYCLIC-AMP, AND PHORBOL ESTER IN PC12 CELLS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article RP NIH, NATL HEART LUNG & BLOOD INST, BIOCHEM GENET LAB, BLDG 36, ROOM 1C06, BETHESDA, MD 20892 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD NOV 15 PY 1990 VL 611 BP 376 EP 377 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB933 UT WOS:A1990FB93300036 ER PT J AU MYERS, AK FARHAT, MY SHEN, GH DEBINSKI, W WAHLESTEDT, C ZUKOWSKAGROJEC, Z AF MYERS, AK FARHAT, MY SHEN, GH DEBINSKI, W WAHLESTEDT, C ZUKOWSKAGROJEC, Z TI PLATELETS AS A SOURCE AND SITE OF ACTION FOR NEUROPEPTIDE-Y SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 NCI, MOLEC BIOL LAB, BETHESDA, MD 20892 USA. CORNELL UNIV, MED CTR, COLL MED, DEPT NEUROL, DIV NEUROBIOL, NEW YORK, NY 10021 USA. RP GEORGETOWN UNIV, SCH MED, DEPT PHYSIOL & BIOPHYS, 3900 RESERVOIR RD NW, WASHINGTON, DC 20007 USA. RI Wahlestedt, Claes/A-7039-2009 NR 4 TC 2 Z9 2 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD NOV 15 PY 1990 VL 611 BP 408 EP 411 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB933 UT WOS:A1990FB93300048 ER PT J AU GROJEC, MS ISHAC, EJN KAPOCSI, J KUNOS, G AF GROJEC, MS ISHAC, EJN KAPOCSI, J KUNOS, G TI THE EFFECT OF ESSENTIAL FATTY-ACID DEFICIENCY ON THE ADRENERGIC ACTIVATION OF GLYCOGENOLYSIS IN RAT HEPATOCYTES SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NIAAA,PHYSIOL & PHARMACOL STUDIES LAB,12501 WASHINGTON AVE,ROCKVILLE,MD 20852. OI Kapocsi, Judit/0000-0003-0204-0009 NR 35 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD NOV 15 PY 1990 VL 283 IS 1 BP 34 EP 39 DI 10.1016/0003-9861(90)90608-2 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EH560 UT WOS:A1990EH56000005 PM 2173490 ER PT J AU BOUTELJE, J KARLSTROM, AR HARTMANIS, MGN HOLMGREN, E SJOGREN, A LEVINE, RL AF BOUTELJE, J KARLSTROM, AR HARTMANIS, MGN HOLMGREN, E SJOGREN, A LEVINE, RL TI HUMAN IMMUNODEFICIENCY VIRAL PROTEASE IS CATALYTICALLY ACTIVE AS A FUSION PROTEIN - CHARACTERIZATION OF THE FUSION AND NATIVE ENZYMES PRODUCED IN ESCHERICHIA-COLI SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NHLBI,BIOCHEM LAB,BLDG 3,ROOM 106,BETHESDA,MD 20892. KABIGEN AB,S-11247 STOCKHOLM,SWEDEN. RI Levine, Rodney/D-9885-2011 NR 54 TC 23 Z9 23 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD NOV 15 PY 1990 VL 283 IS 1 BP 141 EP 149 DI 10.1016/0003-9861(90)90624-8 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EH560 UT WOS:A1990EH56000021 PM 2241167 ER PT J AU KYOGASHIMA, M KRIVAN, HC SCHWEINLE, JE GINSBURG, V HOLT, GD AF KYOGASHIMA, M KRIVAN, HC SCHWEINLE, JE GINSBURG, V HOLT, GD TI GLYCOSPHINGOLIPID-BINDING SPECIFICITY OF THE MANNOSE-BINDING PROTEIN FROM HUMAN SERA SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article C1 NIDDKD,STRUCT BIOL LAB,BLDG 8,ROOM 2A-27,BETHESDA,MD 20892. YALE UNIV,SCH MED,DEPT INTERNAL MED,DIV INFECT DIS,NEW HAVEN,CT 06510. NR 32 TC 19 Z9 19 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD NOV 15 PY 1990 VL 283 IS 1 BP 217 EP 222 DI 10.1016/0003-9861(90)90634-B PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EH560 UT WOS:A1990EH56000031 PM 2241172 ER PT J AU OWENS, RA NEBERT, DW AF OWENS, RA NEBERT, DW TI EXPRESSION OF THE CHLORAMPHENICOL ACETYLTRANSFERASE (CAT) REPORTER GENE BY THE MURINE CYPLA-2 (CYTOCHROME-P3450) PROMOTER IN HEPATOMA-CELL CULTURES SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article C1 UNIV CINCINNATI,MED CTR,DEPT ENVIRONM HLTH,CINCINNATI,OH 45267. NICHHD,DEV PHARMACOL LAB,BETHESDA,MD 20892. FU NIEHS NIH HHS [5 F32 ESO5360-03 BI-7] NR 46 TC 8 Z9 8 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 15 PY 1990 VL 172 IS 3 BP 1109 EP 1115 DI 10.1016/0006-291X(90)91561-6 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EJ240 UT WOS:A1990EJ24000022 PM 2173915 ER PT J AU SALMINEN, A GOTTESMAN, MM AF SALMINEN, A GOTTESMAN, MM TI INHIBITOR STUDIES INDICATE THAT ACTIVE CATHEPSIN-L IS PROBABLY ESSENTIAL TO ITS OWN PROCESSING IN CULTURED FIBROBLASTS SO BIOCHEMICAL JOURNAL LA English DT Article C1 NCI,CELL BIOL LAB,BLDG 37,ROOM 2E18,BETHESDA,MD 20892. UNIV JYVASKYLA,DEPT CELL BIOL,SF-40100 IYVASKYLA,FINLAND. NR 32 TC 47 Z9 47 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD NOV 15 PY 1990 VL 272 IS 1 BP 39 EP 44 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EK066 UT WOS:A1990EK06600005 PM 2264836 ER PT J AU METCALFE, DD THOMPSON, HL KLEBANOFF, SJ HENDERSON, WR AF METCALFE, DD THOMPSON, HL KLEBANOFF, SJ HENDERSON, WR TI OXIDATIVE-DEGRADATION OF RAT MAST-CELL HEPARIN PROTEOGLYCAN SO BIOCHEMICAL JOURNAL LA English DT Article C1 UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195. NIAID,CLIN INVEST LAB,MAST CELL PHYSIOL SECT,BETHESDA,MD 20892. FU NIAID NIH HHS [AI07763, AI00487, AI17758] NR 56 TC 29 Z9 29 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD NOV 15 PY 1990 VL 272 IS 1 BP 51 EP 57 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EK066 UT WOS:A1990EK06600007 PM 2176084 ER PT J AU MCLEOD, DR HOEHNSARIC, R ZIMMERLI, WD DESOUZA, EB OLIVER, LK AF MCLEOD, DR HOEHNSARIC, R ZIMMERLI, WD DESOUZA, EB OLIVER, LK TI TREATMENT EFFECTS OF ALPRAZOLAM AND IMIPRAMINE - PHYSIOLOGICAL VERSUS SUBJECTIVE CHANGES IN PATIENTS WITH GENERALIZED ANXIETY DISORDER SO BIOLOGICAL PSYCHIATRY LA English DT Article C1 NIDA,ADDICT RES CTR,BALTIMORE,MD. JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205. UPJOHN CO,KALAMAZOO,MI 49001. FU NIMH NIH HHS [MH35435] NR 39 TC 24 Z9 24 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD NOV 15 PY 1990 VL 28 IS 10 BP 849 EP 861 DI 10.1016/0006-3223(90)90567-L PG 13 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EJ241 UT WOS:A1990EJ24100003 PM 2268689 ER PT J AU WRIGHT, JJ WAGNER, DK BLAESE, RM HAGENGRUBER, C WALDMANN, TA FLEISHER, TA AF WRIGHT, JJ WAGNER, DK BLAESE, RM HAGENGRUBER, C WALDMANN, TA FLEISHER, TA TI CHARACTERIZATION OF COMMON VARIABLE IMMUNODEFICIENCY - IDENTIFICATION OF A SUBSET OF PATIENTS WITH DISTINCTIVE IMMUNOPHENOTYPIC AND CLINICAL-FEATURES SO BLOOD LA English DT Article C1 NIH,CTR CLIN,DEPT CLIN PATHOL,IMMUNOL SERV,BLDG 10,ROOM 2C410,9000 ROCKVILLE PIKE,BETHESDA,MD 20892. NCI,METAB BRANCH,BETHESDA,MD 20892. NR 38 TC 109 Z9 109 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1990 VL 76 IS 10 BP 2046 EP 2051 PG 6 WC Hematology SC Hematology GA EJ391 UT WOS:A1990EJ39100021 PM 2146980 ER PT J AU MEDEIROS, LJ VANKRIEKEN, JH JAFFE, ES RAFFELD, M AF MEDEIROS, LJ VANKRIEKEN, JH JAFFE, ES RAFFELD, M TI ASSOCIATION OF BCL-1 REARRANGEMENTS WITH LYMPHOCYTIC LYMPHOMA OF INTERMEDIATE DIFFERENTIATION SO BLOOD LA English DT Article C1 NCI,PATHOL LAB,HEMATOPATHOL,BLDG 10,ROOM 2N110,BETHESDA,MD 20892. RI van Krieken, Joannes/D-4138-2009 OI van Krieken, Joannes/0000-0001-6544-1040 NR 30 TC 189 Z9 189 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1990 VL 76 IS 10 BP 2086 EP 2090 PG 5 WC Hematology SC Hematology GA EJ391 UT WOS:A1990EJ39100027 PM 2242428 ER PT J AU CHOCHUNG, YS AF CHOCHUNG, YS TI ROLE OF CYCLIC-AMP RECEPTOR PROTEINS IN GROWTH, DIFFERENTIATION, AND SUPPRESSION OF MALIGNANCY - NEW APPROACHES TO THERAPY SO CANCER RESEARCH LA English DT Review RP CHOCHUNG, YS (reprint author), NCI,TUMOR IMMUNOL & BIOL LAB,CELLULAR BIOCHEM SECT,BETHESDA,MD 20892, USA. NR 110 TC 278 Z9 282 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7093 EP 7100 PG 8 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600001 PM 2224844 ER PT J AU HEBERT, CD CAO, QL BIRNBAUM, LS AF HEBERT, CD CAO, QL BIRNBAUM, LS TI ROLE OF TRANSFORMING GROWTH-FACTOR-BETA IN THE PROLIFERATIVE EFFECT OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN ON HUMAN SQUAMOUS CARCINOMA-CELLS SO CANCER RESEARCH LA English DT Article C1 UNIV N CAROLINA,CHAPEL HILL,NC 27599. RP HEBERT, CD (reprint author), NIEHS,EXPTL TOXICOL BRANCH,POB 12233,RES TRIANGLE PK,NC 27709, USA. NR 59 TC 9 Z9 9 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7190 EP 7197 PG 8 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600017 PM 2171758 ER PT J AU AVRAMIS, VI CHAMPAGNE, J SATO, J KRAILO, M ETTINGER, LJ POPLACK, DG FINKELSTEIN, J REAMAN, G HAMMOND, GD HOLCENBERG, JS AF AVRAMIS, VI CHAMPAGNE, J SATO, J KRAILO, M ETTINGER, LJ POPLACK, DG FINKELSTEIN, J REAMAN, G HAMMOND, GD HOLCENBERG, JS TI PHARMACOLOGY OF FLUDARABINE PHOSPHATE AFTER A PHASE-I-II TRIAL BY A LOADING BOLUS AND CONTINUOUS INFUSION IN PEDIATRIC-PATIENTS SO CANCER RESEARCH LA English DT Article C1 ST JEAN SUR RICHELIEU,QUEBEC CITY,QUEBEC,CANADA. CHILDRENS CANC STUDY GRP,LOS ANGELES,CA 91101. UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,NEW BRUNSWICK,NJ 08901. UNIV CALIF LOS ANGELES,MILLERS CHILDRENS HOSP,LONG BEACH,CA 90509. CHILDRENS NATL MED CTR,WASHINGTON,DC. NCI,PEDIAT BRANCH,BETHESDA,MD 20892. RP AVRAMIS, VI (reprint author), UNIV SO CALIF,CHILDRENS HOSP,DIV HEMATOL ONCOL,4650 SUNSET BLVD,LOS ANGELES,CA 90027, USA. FU NCI NIH HHS [U10-CA02649] NR 29 TC 42 Z9 43 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7226 EP 7231 PG 6 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600024 PM 1699658 ER PT J AU GREM, JL ALLEGRA, CJ AF GREM, JL ALLEGRA, CJ TI ENHANCEMENT OF THE TOXICITY AND DNA INCORPORATION OF ARABINOSYL-5-AZACYTOSINE AND 1-BETA-D-ARABINOFURANOSYLCYTOSINE BY CYCLOPENTENYL CYTOSINE SO CANCER RESEARCH LA English DT Article RP GREM, JL (reprint author), NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,MED BRANCH,GASTROINTESTINAL TUMOR SECT,BLDG 10,BETHESDA,MD 20892, USA. NR 30 TC 27 Z9 27 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7279 EP 7284 PG 6 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600033 PM 1699659 ER PT J AU CLARK, JW SMITH, JW STEIS, RG URBA, WJ CRUM, E MILLER, R MCKNIGHT, J BEMAN, JA STEVENSON, HC CREEKMORE, S STEWART, M CONLON, K SZNOL, M KREMERS, P COHEN, P LONGO, DL AF CLARK, JW SMITH, JW STEIS, RG URBA, WJ CRUM, E MILLER, R MCKNIGHT, J BEMAN, JA STEVENSON, HC CREEKMORE, S STEWART, M CONLON, K SZNOL, M KREMERS, P COHEN, P LONGO, DL TI INTERLEUKIN-2 AND LYMPHOKINE-ACTIVATED KILLER-CELL THERAPY - ANALYSIS OF A BOLUS INTERLEUKIN-2 AND A CONTINUOUS INFUSION INTERLEUKIN-2 REGIMEN SO CANCER RESEARCH LA English DT Article C1 NCI,DIV CANC TREATMENT,BIOL RESPONSE MODIFIERS PROGRAM,BETHESDA,MD 20892. NCI,DIV CANC BIOL DIAGNOSIS & CTR,PATHOL LAB,BETHESDA,MD 20892. NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,FREDERICK,MD 21701. FREDERICK MEM HOSP,FREDERICK,MD 21701. FU NCI NIH HHS [N01-CO-74102] NR 17 TC 51 Z9 51 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7343 EP 7350 PG 8 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600041 PM 2224862 ER PT J AU SUNG, C YOULE, RJ DEDRICK, RL AF SUNG, C YOULE, RJ DEDRICK, RL TI PHARMACOKINETIC ANALYSIS OF IMMUNOTOXIN UPTAKE IN SOLID TUMORS - ROLE OF PLASMA KINETICS, CAPILLARY-PERMEABILITY, AND BINDING SO CANCER RESEARCH LA English DT Article C1 NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892. RP SUNG, C (reprint author), NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BLDG 13,BETHESDA,MD 20892, USA. NR 36 TC 73 Z9 73 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7382 EP 7392 PG 11 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600047 PM 2224866 ER PT J AU HONOVICH, JP MARKEY, SP AF HONOVICH, JP MARKEY, SP TI MAGNETRON MOTION AND THE TRANSFER OF IONS IN A DUAL CELL ION-CYCLOTRON RESONANCE MASS-SPECTROMETER SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES LA English DT Article RP HONOVICH, JP (reprint author), NIMH,ANALYT BIOCHEM SECT,CLIN SCI LAB,BETHESDA,MD 20892, USA. NR 19 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1176 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. Ion Process. PD NOV 15 PY 1990 VL 101 IS 1 BP 21 EP 34 DI 10.1016/0168-1176(90)80018-X PG 14 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA EM352 UT WOS:A1990EM35200002 ER PT J AU TSAIMORRIS, CH BUCZKO, E WANG, W DUFAU, ML AF TSAIMORRIS, CH BUCZKO, E WANG, W DUFAU, ML TI INTRONIC NATURE OF THE RAT LUTEINIZING-HORMONE RECEPTOR GENE DEFINES A SOLUBLE RECEPTOR SUBSPECIES WITH HORMONE BINDING-ACTIVITY SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note C1 NICHHD,ENDOCRINOL & REPROD RES BRANCH,MOLEC ENDOCRINOL SECT,BLDG 10,RM B1-L400,BETHESDA,MD 20892. NR 25 TC 216 Z9 217 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19385 EP 19388 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800004 PM 2174034 ER PT J AU JONES, TLZ SPIEGEL, AM AF JONES, TLZ SPIEGEL, AM TI ISOPRENYLATION OF AN INHIBITORY G-PROTEIN-ALPHA SUBUNIT OCCURS ONLY UPON MUTAGENESIS OF THE CARBOXYL TERMINUS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note RP JONES, TLZ (reprint author), NIDDK,MOLEC PATHOPHYSIOL BRANCH,BLDG 10,RM 8D17,BETHESDA,MD 20892, USA. NR 31 TC 22 Z9 23 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19389 EP 19392 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800005 PM 2123186 ER PT J AU SALUSTRI, A ULISSE, S YANAGISHITA, M HASCALL, VC AF SALUSTRI, A ULISSE, S YANAGISHITA, M HASCALL, VC TI HYALURONIC-ACID SYNTHESIS BY MURAL GRANULOSA-CELLS AND CUMULUS CELLS-INVITRO IS SELECTIVELY STIMULATED BY A FACTOR PRODUCED BY OOCYTES AND BY TRANSFORMING GROWTH-FACTOR-BETA SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NIDA, BONE RES BRANCH, BETHESDA, MD 20892 USA. RP SALUSTRI, A (reprint author), UNIV ROME 2, FAC MED, DEPT SANITA PUBBL & BIOL CELLULARE, I-00173 ROME, ITALY. OI SALUSTRI, ANTONIETTA/0000-0002-8731-1041 NR 32 TC 103 Z9 104 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19517 EP 19523 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800027 PM 2123188 ER PT J AU CARROLL, MP CLARKLEWIS, I RAPP, UR MAY, WS AF CARROLL, MP CLARKLEWIS, I RAPP, UR MAY, WS TI INTERLEUKIN-3 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR MEDIATE RAPID PHOSPHORYLATION AND ACTIVATION OF CYTOSOLIC-C-RAF SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 JOHNS HOPKIN ONCOL CTR,424 N BOND ST,BALTIMORE,MD 21231. UNIV BRITISH COLUMBIA,BIOMED RES CTR,VANCOUVER V6T 1W5,BC,CANADA. NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701. FU NCI NIH HHS [CA 47993, CA 44649] NR 46 TC 177 Z9 178 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19812 EP 19817 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800069 PM 1700980 ER PT J AU ROTROSEN, D LETO, TL AF ROTROSEN, D LETO, TL TI PHOSPHORYLATION OF NEUTROPHIL 47-KDA CYTOSOLIC OXIDASE FACTOR - TRANSLOCATION TO MEMBRANE IS ASSOCIATED WITH DISTINCT PHOSPHORYLATION EVENTS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP ROTROSEN, D (reprint author), NIAID,BACTERIAL DIS SECT,CLIN INVEST LAB,BLDG 10,RM 11N112,BETHESDA,MD 20892, USA. NR 42 TC 222 Z9 226 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19910 EP 19915 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800083 PM 2246268 ER PT J AU CHEN, KH WIDEN, SG WILSON, SH HUANG, KP AF CHEN, KH WIDEN, SG WILSON, SH HUANG, KP TI CHARACTERIZATION OF THE 5'-FLANKING REGION OF THE RAT PROTEIN-KINASE-C GAMMA-GENE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892. RP CHEN, KH (reprint author), NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892, USA. NR 37 TC 20 Z9 22 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19961 EP 19965 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800092 PM 2246272 ER PT J AU DAYAN, I WEISS, GH AF DAYAN, I WEISS, GH TI KINETIC-BEHAVIOR OF DIFFUSION-SYSTEMS IN THE PRESENCE OF NON-MARKOVIAN BOUNDARIES SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article C1 NIH, BETHESDA, MD 20892 USA. RP DAYAN, I (reprint author), BAR ILAN UNIV, DEPT PHYS, IL-52100 RAMAT GAN, ISRAEL. NR 11 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 15 PY 1990 VL 93 IS 10 BP 7374 EP 7377 DI 10.1063/1.459412 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EJ461 UT WOS:A1990EJ46100052 ER PT J AU FRANCIS, ML MOSS, J FITZ, TA MOND, JJ AF FRANCIS, ML MOSS, J FITZ, TA MOND, JJ TI CAMP-INDEPENDENT EFFECTS OF CHOLERA-TOXIN ON B-CELL ACTIVATION .1. A POSSIBLE ROLE FOR CELL-SURFACE GANGLIOSIDE-GM1 IN B-CELL ACTIVATION SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 UNIFORMED SERV UNIV HLTH SCI,DEPT OBSTET & GYNECOL,BETHESDA,MD 20814. NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892. RP FRANCIS, ML (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,ROOM A3060,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NIAID NIH HHS [R01 AI24273, R01 AI21328] NR 42 TC 28 Z9 28 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3162 EP 3169 PG 8 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900002 PM 2172379 ER PT J AU SYKES, M AF SYKES, M TI UNUSUAL T-CELL POPULATIONS IN ADULT MURINE BONE-MARROW - PREVALENCE OF CD3+CD4-CD8- AND ALPHA-BETA-TCR+NK1.1+ CELLS SO JOURNAL OF IMMUNOLOGY LA English DT Article RP SYKES, M (reprint author), NCI,IMMUNOL BRANCH,BLDG 10,ROOM 4B13,BETHESDA,MD 20892, USA. NR 34 TC 211 Z9 212 U1 2 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3209 EP 3215 PG 7 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900009 PM 1977798 ER PT J AU VIA, CS SHANLEY, JD SHEARER, GM AF VIA, CS SHANLEY, JD SHEARER, GM TI SYNERGISTIC EFFECT OF MURINE CYTOMEGALOVIRUS ON THE INDUCTION OF ACUTE GRAFT-VS-HOST DISEASE INVOLVING MHC CLASS-I DIFFERENCES ONLY - ANALYSIS OF INVITRO T-CELL FUNCTION SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 LOCH RAVEN VET ADM MED CTR,RES SERV,BALTIMORE,MD 21201. UNIV CONNECTICUT,VET ADM MED CTR,DEPT MED,NEWINGTON,CT 06111. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. RP VIA, CS (reprint author), UNIV MARYLAND,SCH MED,DIV RHEUMATOL & CLIN IMMUNOL,MSTF 8-34,10 S PINE ST,BALTIMORE,MD 21201, USA. NR 37 TC 20 Z9 20 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3283 EP 3289 PG 7 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900019 PM 2172381 ER PT J AU BIRCHENALLROBERTS, MC FERRER, C FERRIS, D FALK, LA KASPER, J WHITE, G RUSCETTI, FW AF BIRCHENALLROBERTS, MC FERRER, C FERRIS, D FALK, LA KASPER, J WHITE, G RUSCETTI, FW TI INHIBITION OF MURINE MONOCYTE PROLIFERATION BY A COLONY-STIMULATING FACTOR-I ANTISENSE OLIGODEOXYNUCLEOTIDE - EVIDENCE FOR AUTOCRINE REGULATION SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NCI,FREDERICK CANC RES FACIL,PROGRAM RESOURCES INC,BIOL CARCINOGENESIS DEV PROGRAM,FREDERICK,MD 21701. RP BIRCHENALLROBERTS, MC (reprint author), NCI,FREDERICK CANC RES FACIL,DIV CANC TREATMENT,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701, USA. FU NCI NIH HHS [N01-CO-74102] NR 27 TC 28 Z9 28 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3290 EP 3296 PG 7 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900020 PM 2146319 ER PT J AU LYCKE, N SEVERINSON, E STROBER, W AF LYCKE, N SEVERINSON, E STROBER, W TI CHOLERA-TOXIN ACTS SYNERGISTICALLY WITH IL-4 TO PROMOTE IGG1 SWITCH DIFFERENTIATION SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 UNIV STOCKHOLM,DEPT IMMUNOL,S-10691 STOCKHOLM,SWEDEN. NIAID,MUCOSAL IMMUN SECT,CLIN INVEST LAB,BETHESDA,MD 20892. RP LYCKE, N (reprint author), GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,S-41346 GOTHENBURG,SWEDEN. NR 26 TC 72 Z9 72 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3316 EP 3324 PG 9 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900024 PM 1700007 ER PT J AU THOMPSON, HL BURBELO, PD METCALFE, DD AF THOMPSON, HL BURBELO, PD METCALFE, DD TI REGULATION OF ADHESION OF MOUSE BONE MARROW-DERIVED MAST-CELLS TO LAMININ SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 NIDR,DEV BIOL & ANOMALIES LAB,BETHESDA,MD 20892. RP THOMPSON, HL (reprint author), NIAID,MAST CELL PHYSIOL SECT,CLIN INVEST LAB,ROOM 11C208,BLDG 10,BETHESDA,MD 20892, USA. RI Burbelo, Peter/B-1027-2009 NR 34 TC 61 Z9 61 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3425 EP 3431 PG 7 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900040 PM 2146320 ER PT J AU WATKINS, DI CHEN, ZW HUGHES, AL LAGOS, A LEWIS, AM SHADDUCK, JA LETVIN, NL AF WATKINS, DI CHEN, ZW HUGHES, AL LAGOS, A LEWIS, AM SHADDUCK, JA LETVIN, NL TI SYRIAN-HAMSTERS EXPRESS DIVERSE MHC CLASS-I GENE-PRODUCTS SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 UNIV TEXAS,HLTH SCI CTR,CTR DEMOG & POPULAT GENET,HOUSTON,TX 77225. NIAID,VIRAL PATHOGENESIS SECT,IMMUNOPATHOL LAB,BETHESDA,MD 20892. TEXAS A&M UNIV SYST,COLL VET MED,COLLEGE STN,TX 77843. RP WATKINS, DI (reprint author), HARVARD UNIV,NEW ENGLAND REG PRIMATE RES CTR,SCH MED,1 PINE HILL DR,SOUTHBOROUGH,MA 01772, USA. FU NCI NIH HHS [CA 31363]; NCRR NIH HHS [RR00168]; NIMHD NIH HHS [263-MD-000733] NR 63 TC 10 Z9 10 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3483 EP 3490 PG 8 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900049 PM 2230131 ER PT J AU CANNON, RO QUYYUMI, AA SCHENKE, WH FANANAPAZIR, L TUCKER, EE GAUGHAN, AM GRACELY, RH CATTAU, EL EPSTEIN, SE AF CANNON, RO QUYYUMI, AA SCHENKE, WH FANANAPAZIR, L TUCKER, EE GAUGHAN, AM GRACELY, RH CATTAU, EL EPSTEIN, SE TI ABNORMAL CARDIAC SENSITIVITY IN PATIENTS WITH CHEST PAIN AND NORMAL CORONARY-ARTERIES SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article C1 NIDR,NEUROBIOL & ANESTHESIOL BRANCH,CLIN PAIN SECT,BETHESDA,MD 20892. GEORGETOWN UNIV,SCH MED,DIV GASTROENTEROL,WASHINGTON,DC. RP CANNON, RO (reprint author), NHLBI,CARDIOL BRANCH,CARDIOVASC DIAG SECT,BLDG 10,ROOM 7B15,BETHESDA,MD 20892, USA. NR 27 TC 143 Z9 145 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD NOV 15 PY 1990 VL 16 IS 6 BP 1359 EP 1366 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EK084 UT WOS:A1990EK08400006 PM 2229787 ER PT J AU JACOBSON, S SHIDA, H MCFARLIN, DE FAUCI, AS KOENIG, S AF JACOBSON, S SHIDA, H MCFARLIN, DE FAUCI, AS KOENIG, S TI CIRCULATING CD8+ CYTOTOXIC LYMPHOCYTES-T SPECIFIC FOR HTLV-I PX IN PATIENTS WITH HTLV-I ASSOCIATED NEUROLOGICAL DISEASE SO NATURE LA English DT Article C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. KYOTO UNIV,INST VIROL,KYOTO 606,JAPAN. RP JACOBSON, S (reprint author), NINCDS,NEUROIMMUNOL BRANCH,BETHESDA,MD 20892, USA. NR 23 TC 512 Z9 513 U1 0 U2 2 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD NOV 15 PY 1990 VL 348 IS 6298 BP 245 EP 248 DI 10.1038/348245a0 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH796 UT WOS:A1990EH79600061 PM 2146511 ER PT J AU ZAMETKIN, AJ NORDAHL, TE GROSS, M KING, AC SEMPLE, WE RUMSEY, J HAMBURGER, S COHEN, RM AF ZAMETKIN, AJ NORDAHL, TE GROSS, M KING, AC SEMPLE, WE RUMSEY, J HAMBURGER, S COHEN, RM TI CEREBRAL GLUCOSE-METABOLISM IN ADULTS WITH HYPERACTIVITY OF CHILDHOOD ONSET SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article C1 NIMH,CHILD PSYCHIAT BRANCH,BETHESDA,MD 20892. RP ZAMETKIN, AJ (reprint author), NIMH,CEREBRAL METAB LAB,CLIN BRAIN IMAGING SECT,BLDG 10 4N317,BETHESDA,MD 20892, USA. RI Nordahl, Thomas/J-7643-2013 OI Nordahl, Thomas/0000-0002-8627-0356 NR 32 TC 616 Z9 631 U1 0 U2 9 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 15 PY 1990 VL 323 IS 20 BP 1361 EP 1366 DI 10.1056/NEJM199011153232001 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA EH546 UT WOS:A1990EH54600001 PM 2233902 ER PT J AU ROBBINS, JB SCHNEERSON, R AF ROBBINS, JB SCHNEERSON, R TI EVALUATING THE HAEMOPHILUS-INFLUENZAE TYPE-B CONJUGATE VACCINE PRP-D SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material RP ROBBINS, JB (reprint author), NICHHD,BETHESDA,MD 20892, USA. NR 19 TC 24 Z9 24 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 15 PY 1990 VL 323 IS 20 BP 1415 EP 1416 DI 10.1056/NEJM199011153232010 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EH546 UT WOS:A1990EH54600010 PM 2233910 ER PT J AU BUNDE, A HAVLIN, S ROMAN, HE AF BUNDE, A HAVLIN, S ROMAN, HE TI MULTIFRACTAL FEATURES OF RANDOM-WALKS ON RANDOM FRACTALS SO PHYSICAL REVIEW A LA English DT Note C1 NIH,DIV COMP RES & TECHNOL,BETHESDA,MD 20205. RP BUNDE, A (reprint author), UNIV HAMBURG,INST THEORET PHYS 1,JUNGIUSSTR 9,W-2000 HAMBURG 36,GERMANY. NR 18 TC 72 Z9 73 U1 1 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD NOV 15 PY 1990 VL 42 IS 10 BP 6274 EP 6277 DI 10.1103/PhysRevA.42.6274 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA EJ421 UT WOS:A1990EJ42100063 ER PT J AU RANDALL, PS AF RANDALL, PS TI ANTI-HIV DRUG AVAILABLE IN TRIALS SO POSTGRADUATE MEDICINE LA English DT Letter RP RANDALL, PS (reprint author), NIAID,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD NOV 15 PY 1990 VL 88 IS 7 BP 23 EP 23 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EJ420 UT WOS:A1990EJ42000007 PM 2122427 ER PT J AU BAGDY, G CALOGERO, AE SZEMEREDI, K CHROUSOS, GP GOLD, PW AF BAGDY, G CALOGERO, AE SZEMEREDI, K CHROUSOS, GP GOLD, PW TI EFFECTS OF CORTISOL TREATMENT ON BRAIN AND ADRENAL CORTICOTROPIN-RELEASING HORMONE (CRH) CONTENT AND OTHER PARAMETERS REGULATED BY CRH SO REGULATORY PEPTIDES LA English DT Article C1 NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NINCDS,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892. RP BAGDY, G (reprint author), NIMH,CTR CLIN,CLIN NEUROENDOCRINOL BRANCH,10-3S231,BETHESDA,MD 20892, USA. OI Bagdy, Gyorgy/0000-0001-8141-3410 NR 44 TC 26 Z9 27 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-0115 J9 REGUL PEPTIDES JI Regul. Pept. PD NOV 15 PY 1990 VL 31 IS 2 BP 83 EP 92 DI 10.1016/0167-0115(90)90111-9 PG 10 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA EJ973 UT WOS:A1990EJ97300001 PM 2176309 ER PT J AU GERSTEN, DM BIJWAARD, KE LAW, LW HEARING, VJ AF GERSTEN, DM BIJWAARD, KE LAW, LW HEARING, VJ TI HOMOLOGY OF THE B50 MURINE MELANOMA ANTIGEN TO THE RO/SS-A ANTIGEN OF HUMAN SYSTEMIC LUPUS-ERYTHEMATOSUS AND TO CALCIUM-BINDING PROTEINS SO BIOCHIMICA ET BIOPHYSICA ACTA LA English DT Article C1 NCI,CELL BIOL LAB,BETHESDA,MD 20892. RP GERSTEN, DM (reprint author), GEORGETOWN UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20007, USA. NR 37 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-3002 J9 BIOCHIM BIOPHYS ACTA PD NOV 14 PY 1990 VL 1096 IS 1 BP 20 EP 25 DI 10.1016/0925-4439(90)90007-C PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EM115 UT WOS:A1990EM11500004 PM 2268681 ER PT J AU SINHA, BK ANTHOLINE, WM KALYANARAMAN, B ELIOT, HM AF SINHA, BK ANTHOLINE, WM KALYANARAMAN, B ELIOT, HM TI COPPER ION-DEPENDENT OXY-RADICAL MEDIATED DNA DAMAGE FROM DIHYDROXY DERIVATIVE OF ETOPOSIDE SO BIOCHIMICA ET BIOPHYSICA ACTA LA English DT Note C1 NATL BIOMED ESR CTR,MILWAUKEE,WI. RP SINHA, BK (reprint author), NCI,MED BRANCH,BIOCHEM PHARMACOL SECT,BLDG 10,ROOM 6N-119,BETHESDA,MD 20892, USA. NR 14 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-3002 J9 BIOCHIM BIOPHYS ACTA PD NOV 14 PY 1990 VL 1096 IS 1 BP 81 EP 83 DI 10.1016/0925-4439(90)90015-H PG 3 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EM115 UT WOS:A1990EM11500012 PM 2176549 ER PT J AU LONDON, RE DAVIS, DG VAVREK, RJ STEWART, JM HANDSCHUMACHER, RE AF LONDON, RE DAVIS, DG VAVREK, RJ STEWART, JM HANDSCHUMACHER, RE TI BRADYKININ AND ITS GLY6 ANALOG ARE SUBSTRATES OF CYCLOPHILIN - A F-19 MAGNETIZATION TRANSFER STUDY SO BIOCHEMISTRY LA English DT Article C1 UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262. YALE UNIV,DEPT PHARMACOL,NEW HAVEN,CT 06510. RP LONDON, RE (reprint author), NIEHS,MOLEC BIOPHYS LAB,MD 17-05,BOX 12233,RES TRIANGLE PK,NC 27709, USA. NR 44 TC 24 Z9 24 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 13 PY 1990 VL 29 IS 45 BP 10298 EP 10302 DI 10.1021/bi00497a002 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EH687 UT WOS:A1990EH68700002 PM 2261473 ER PT J AU MURPHY, LD HERZOG, CE RUDICK, JB FOJO, AT BATES, SE AF MURPHY, LD HERZOG, CE RUDICK, JB FOJO, AT BATES, SE TI USE OF THE POLYMERASE CHAIN-REACTION IN THE QUANTITATION OF MDR-1 GENE-EXPRESSION SO BIOCHEMISTRY LA English DT Article C1 NCI,MED BRANCH,BLDG 10,ROOM 12N226,BETHESDA,MD 20892. NR 13 TC 442 Z9 443 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 13 PY 1990 VL 29 IS 45 BP 10351 EP 10356 DI 10.1021/bi00497a009 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EH687 UT WOS:A1990EH68700009 PM 1979752 ER PT J AU HARRISON, NL LOVINGER, DM LAMBERT, NA TEYLER, TJ PRAGER, R ONG, J KERR, DIB AF HARRISON, NL LOVINGER, DM LAMBERT, NA TEYLER, TJ PRAGER, R ONG, J KERR, DIB TI THE ACTIONS OF 2-HYDROXY-SACLOFEN AT PRESYNAPTIC GABA-B RECEPTORS IN THE RAT HIPPOCAMPUS SO NEUROSCIENCE LETTERS LA English DT Article C1 NIAAA,PHYSIOL & PHARMACOL STUDIES LAB,ROCKVILLE,MD 20852. NORTHEASTERN OHIO UNIV,COLL MED,DEPT NEUROBIOL,ROOTSTOWN,OH 44272. FLINDERS UNIV,SCH PHYS SCI,BEDFORD PK,SA 5042,AUSTRALIA. UNIV ADELAIDE,DEPT ANAESTHESIA & INTENS CARE,ADELAIDE,SA 5001,AUSTRALIA. 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NR 23 TC 17 Z9 17 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-3002 J9 BIOCHIM BIOPHYS ACTA PD NOV 12 PY 1990 VL 1055 IS 2 BP 151 EP 156 DI 10.1016/0167-4889(90)90115-T PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EK232 UT WOS:A1990EK23200009 PM 2242383 ER PT J AU BRAUN, DE FREED, WJ AF BRAUN, DE FREED, WJ TI EFFECT OF NIFEDIPINE AND ANTICONVULSANTS ON KAINIC ACID-INDUCED SEIZURES IN MICE SO BRAIN RESEARCH LA English DT Note C1 NIMH,NEUROSCI CTR ST ELIZABETHS,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032. USN HOSP,DEPT NEUROSURG,BETHESDA,MD 20814. NR 23 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. 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PD NOV 7 PY 1990 VL 264 IS 17 BP 2191 EP 2191 DI 10.1001/jama.264.17.2191 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EF488 UT WOS:A1990EF48800006 PM 2214090 ER PT J AU RAUB, W AF RAUB, W TI IMMUNOGENETIC BASIS OF CHRONIC LYME ARTHRITIS IDENTIFIED SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material RP RAUB, W (reprint author), NIH,BETHESDA,MD 20892, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. 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PD NOV 7 PY 1990 VL 82 IS 21 BP 1722 EP 1723 DI 10.1093/jnci/82.21.1722-a PG 2 WC Oncology SC Oncology GA EH048 UT WOS:A1990EH04800022 ER PT J AU DERYNCK, R BALENTIEN, E HAN, JH THOMAS, HG WEN, DZ SAMANTHA, AK ZACHARIAE, CO GRIFFIN, PR BRACHMANN, R WONG, WL MATSUSHIMA, K RICHMOND, A AF DERYNCK, R BALENTIEN, E HAN, JH THOMAS, HG WEN, DZ SAMANTHA, AK ZACHARIAE, CO GRIFFIN, PR BRACHMANN, R WONG, WL MATSUSHIMA, K RICHMOND, A TI RECOMBINANT EXPRESSION, BIOCHEMICAL-CHARACTERIZATION, AND BIOLOGICAL-ACTIVITIES OF THE HUMAN MGSA-GRO PROTEIN SO BIOCHEMISTRY LA English DT Article C1 NCI, DIV CANC TREATMENT, BIOL RESPONSE MODIFIERS PROGRAM, MOLEC IMMUNOREGULAT LAB, FREDERICK, MD 21701 USA. VET ADM MED CTR, ATLANTA, GA 30033 USA. EMORY UNIV, SCH MED, ATLANTA, GA 30322 USA. GENENTECH INC, DEPT PROT BIOCHEM, S SAN FRANCISCO, CA 94080 USA. RP DERYNCK, R (reprint author), GENENTECH INC, DEPT DEV BIOL, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA. RI Richmond, Ann/A-3048-2014 FU NCI NIH HHS [CA34590] NR 62 TC 74 Z9 75 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 6 PY 1990 VL 29 IS 44 BP 10225 EP 10233 DI 10.1021/bi00496a011 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EG222 UT WOS:A1990EG22200011 PM 2271650 ER PT J AU WINSLOW, JT INSEL, TR TRULLAS, R SKOLNICK, P AF WINSLOW, JT INSEL, TR TRULLAS, R SKOLNICK, P TI RAT PUP ISOLATION CALLS ARE REDUCED BY FUNCTIONAL ANTAGONISTS OF THE NMDA RECEPTOR COMPLEX SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article C1 NIMH,ADAMHA,CLIN SCI LAB,POOLESVILLE,MD 20837. NIDDK,NEUROSCI LAB,BETHESDA,MD 20892. RI Trullas, Ramon/D-2197-2016 OI Trullas, Ramon/0000-0001-7951-9881 NR 46 TC 72 Z9 72 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD NOV 6 PY 1990 VL 190 IS 1-2 BP 11 EP 21 DI 10.1016/0014-2999(90)94107-9 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EK184 UT WOS:A1990EK18400002 PM 1963846 ER PT J AU COY, D WANG, LH JIANG, NY JENSEN, R AF COY, D WANG, LH JIANG, NY JENSEN, R TI SHORT CHAIN BOMBESIN PSEUDOPEPTIDES WITH POTENT BOMBESIN RECEPTOR ANTAGONIST ACTIVITY IN RAT AND GUINEA-PIG PANCREATIC ACINAR-CELLS SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article C1 NIH,DIGEST DIS BRANCH,BETHESDA,MD 20892. RP COY, D (reprint author), TULANE UNIV,MED CTR,DEPT MED,PEPTIDE RES LABS,1430 TULANE AVE,NEW ORLEANS,LA 70112, USA. FU NCI NIH HHS [CA-45153] NR 14 TC 28 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD NOV 6 PY 1990 VL 190 IS 1-2 BP 31 EP 38 DI 10.1016/0014-2999(90)94109-B PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EK184 UT WOS:A1990EK18400004 PM 1963850 ER PT J AU HAUGER, RL LORANG, M IRWIN, M AGUILERA, G AF HAUGER, RL LORANG, M IRWIN, M AGUILERA, G TI CRF RECEPTOR REGULATION AND SENSITIZATION OF ACTH RESPONSES TO ACUTE ETHER STRESS DURING CHRONIC INTERMITTENT IMMOBILIZATION STRESS SO BRAIN RESEARCH LA English DT Article C1 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093. VET ADM MED CTR,SAN DIEGO,CA 92161. NIH,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892. RI Irwin, Michael/H-4870-2013 OI Irwin, Michael/0000-0002-1502-8431 FU NIMH NIH HHS [MH30914, MH44275-01] NR 36 TC 176 Z9 178 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD NOV 5 PY 1990 VL 532 IS 1-2 BP 34 EP 40 DI 10.1016/0006-8993(90)91738-3 PG 7 WC Neurosciences SC Neurosciences & Neurology GA EK059 UT WOS:A1990EK05900006 PM 2178035 ER PT J AU HEIDARAN, MA PIERCE, JH JENSEN, RA MATSUI, T AARONSON, SA AF HEIDARAN, MA PIERCE, JH JENSEN, RA MATSUI, T AARONSON, SA TI CHIMERIC ALPHA-PLATELET-DERIVED AND BETA-PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTORS DEFINE 3 IMMUNOGLOBULIN-LIKE DOMAINS OF THE ALPHA-PDGF RECEPTOR THAT DETERMINE PDGF-AA BINDING-SPECIFICITY SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note RP HEIDARAN, MA (reprint author), NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892, USA. RI Matsui, Toshimitsu/E-8065-2010 NR 27 TC 49 Z9 49 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 18741 EP 18744 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900008 PM 2172231 ER PT J AU EGAN, JJ GREENBERG, AS CHANG, MK LONDOS, C AF EGAN, JJ GREENBERG, AS CHANG, MK LONDOS, C TI CONTROL OF ENDOGENOUS PHOSPHORYLATION OF THE MAJOR CAMP-DEPENDENT PROTEIN-KINASE SUBSTRATE IN ADIPOCYTES BY INSULIN AND BETA-ADRENERGIC STIMULATION SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP EGAN, JJ (reprint author), NIDDKD,MEMBRANE REGULAT SECT,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892, USA. FU NIDDK NIH HHS [F32 DK07685] NR 34 TC 85 Z9 85 U1 0 U2 4 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 18769 EP 18775 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900014 PM 2172232 ER PT J AU LAFYATIS, R LECHLEIDER, R KIM, SJ JAKOWLEW, S ROBERTS, AB SPORN, MB AF LAFYATIS, R LECHLEIDER, R KIM, SJ JAKOWLEW, S ROBERTS, AB SPORN, MB TI STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF THE TRANSFORMING GROWTH FACTOR-BETA-3 PROMOTER - A CAMP-RESPONSIVE ELEMENT REGULATES BASAL AND INDUCED TRANSCRIPTION SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP LAFYATIS, R (reprint author), NCI,CHEMOPREVENT LAB,BLDG 41,RM C629,BETHESDA,MD 20892, USA. NR 40 TC 114 Z9 115 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19128 EP 19136 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900070 PM 2146270 ER PT J AU KADOWAKI, T KADOWAKI, H ACCILI, D TAYLOR, SI AF KADOWAKI, T KADOWAKI, H ACCILI, D TAYLOR, SI TI SUBSTITUTION OF LYSINE FOR ASPARAGINE AT POSITION-15 IN THE ALPHA-SUBUNIT OF THE HUMAN INSULIN-RECEPTOR - A MUTATION THAT IMPAIRS TRANSPORT OF RECEPTORS TO THE CELL-SURFACE AND DECREASES THE AFFINITY OF INSULIN BINDING SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NIDDKD,DIABET BRANCH,BLDG 10,RM 8S243,BETHESDA,MD 20892. NR 35 TC 76 Z9 79 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19143 EP 19150 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900072 PM 2121734 ER PT J AU TAKAHASHI, N BREITMAN, TR AF TAKAHASHI, N BREITMAN, TR TI RETINOYLATION OF HL-60 PROTEINS - COMPARISON TO LABELING BY PALMITIC AND MYRISTIC ACIDS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP TAKAHASHI, N (reprint author), NCI,DIV CANC TREATMENT,BIOL CHEM LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892, USA. NR 31 TC 37 Z9 37 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19158 EP 19162 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900074 PM 2229069 ER PT J AU BIFULCO, M SANTILLO, M TEDESCO, I ZARRILLI, R LAEZZA, C ALOJ, SM AF BIFULCO, M SANTILLO, M TEDESCO, I ZARRILLI, R LAEZZA, C ALOJ, SM TI THYROTROPIN MODULATES LOW-DENSITY-LIPOPROTEIN BINDING-ACTIVITY IN FRTL-5 THYROID-CELLS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NAPLES UNIV, DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC L CALI, I-80131 NAPLES, ITALY. UNIV REGGIO CALABRIA, IST ONCOL SPERIMENTALE & CLIN, CATANZARO, ITALY. NIDDKD, BIOCHEM CELL REGULAT SECT, BETHESDA, MD 20892 USA. NIDDKD, BIOCHEM & METAB LAB, BETHESDA, MD 20892 USA. RP BIFULCO, M (reprint author), CNR, CTR ENDOCRINOL & ONCOL SPERIMENTALE, VIA S PANSINI 5, I-80131 NAPLES, ITALY. OI Bifulco, Maurizio/0000-0002-1771-4531 NR 53 TC 13 Z9 13 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19336 EP 19342 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900099 PM 2229079 ER PT J AU GRIECO, D BEG, ZH ROMANO, A BIFULCO, M ALOJ, SM AF GRIECO, D BEG, ZH ROMANO, A BIFULCO, M ALOJ, SM TI CELL-CYCLE PROGRESSION AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE ARE REGULATED BY THYROTROPIN IN FRTL-5 RAT-THYROID CELLS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 NAPLES UNIV,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC L CALIFANO,I-80131 NAPLES,ITALY. UNIV REGGIO CALABRIA,INST ONCOL SPERIMENTALE & CLIN,CATANZARO,ITALY. NHLBI,MOLEC DIS BRANCH,BETHESDA,MD 20892. NIADDKD,BIOCHEM & METAB LAB,BETHESDA,MD 20892. RP GRIECO, D (reprint author), CNR,CTR ENDOCRINOL & ONCOL SPERIMENTALE,VIA S PANSINI 5,I-80131 NAPLES,ITALY. OI Bifulco, Maurizio/0000-0002-1771-4531 NR 54 TC 32 Z9 32 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19343 EP 19350 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900100 PM 2229080 ER PT J AU ORENSTEIN, JM ZIERDT, W ZIERDT, C KOTLER, DP AF ORENSTEIN, JM ZIERDT, W ZIERDT, C KOTLER, DP TI IDENTIFICATION OF SPORES OF ENTEROCYTOZOON-BIENEUSI IN STOOL AND DUODENAL FLUID FROM AIDS PATIENTS SO LANCET LA English DT Letter C1 NIH,DEPT CLIN PATHOL,BETHESDA,MD 20892. ST LUKES ROOSEVELT HOSP,DIV GASTROENTEROL,NEW YORK,NY 10025. RP ORENSTEIN, JM (reprint author), GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20037, USA. NR 10 TC 30 Z9 30 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD NOV 3 PY 1990 VL 336 IS 8723 BP 1127 EP 1128 DI 10.1016/0140-6736(90)92600-M PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EF992 UT WOS:A1990EF99200037 PM 1977998 ER PT J AU BONIFACINO, JS COSSON, P KLAUSNER, RD AF BONIFACINO, JS COSSON, P KLAUSNER, RD TI COLOCALIZED TRANSMEMBRANE DETERMINANTS FOR ER DEGRADATION AND SUBUNIT ASSEMBLY EXPLAIN THE INTRACELLULAR FATE OF TCR CHAINS SO CELL LA English DT Article RP BONIFACINO, JS (reprint author), NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892, USA. OI Bonifacino, Juan S./0000-0002-5673-6370 NR 46 TC 213 Z9 213 U1 0 U2 8 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD NOV 2 PY 1990 VL 63 IS 3 BP 503 EP 513 DI 10.1016/0092-8674(90)90447-M PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EG687 UT WOS:A1990EG68700009 PM 2225064 ER PT J AU SOLOMON, D AF SOLOMON, D TI THE 1988 BETHESDA SYSTEM FOR REPORTING CERVICAL VAGINAL CYTOLOGIC DIAGNOSES - REPLY SO ACTA CYTOLOGICA LA English DT Letter RP SOLOMON, D (reprint author), NCI,CYTOPATHOL SECT,BLDG 10,ROOM 2A19,900 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0001-5547 J9 ACTA CYTOL JI Acta Cytol. PD NOV-DEC PY 1990 VL 34 IS 6 BP 903 EP 903 PG 1 WC Pathology SC Pathology GA EP239 UT WOS:A1990EP23900028 ER PT J AU BIGGAR, RJ AF BIGGAR, RJ TI AIDS INCUBATION IN 1891 HIV SEROCONVERTERS FROM DIFFERENT EXPOSURE GROUPS SO AIDS LA English DT Article C1 DANISH CANC REGISTRY,AIDS RES,COPENHAGEN,DENMARK. RP BIGGAR, RJ (reprint author), NCI,VIRAL EPIDEMIOL BRANCH,EPN 434,6130 EXECUT PLAZA,ROCKVILLE,MD 20852, USA. NR 32 TC 120 Z9 123 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD NOV PY 1990 VL 4 IS 11 BP 1059 EP 1066 DI 10.1097/00002030-199011000-00002 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EN374 UT WOS:A1990EN37400002 PM 2282177 ER PT J AU LISBY, G FREDERIKSEN, J OLESEN, J REITZ, MS AF LISBY, G FREDERIKSEN, J OLESEN, J REITZ, MS TI ABSENCE OF HTLV-I DNA IN BLOOD FROM PATIENTS WITH MULTIPLE-SCLEROSIS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Letter C1 UNIV COPENHAGEN,GENTOFTE HOSP,DEPT NEUROL,DK-1168 COPENHAGEN,DENMARK. NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. RP LISBY, G (reprint author), UNIV COPENHAGEN,HERLEV HOSP,DEPT CLIN MICROBIOL,DK-1168 COPENHAGEN,DENMARK. NR 6 TC 4 Z9 4 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1219 EP 1219 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000060 PM 2078404 ER PT J AU SADAIE, MR MUKHOPADHYAYA, R BENAISSA, ZN PAVLAKIS, GN WONGSTAAL, F AF SADAIE, MR MUKHOPADHYAYA, R BENAISSA, ZN PAVLAKIS, GN WONGSTAAL, F TI CONSERVATIVE MUTATIONS IN THE PUTATIVE METAL-BINDING REGION OF HUMAN-IMMUNODEFICIENCY-VIRUS TAT DISRUPT VIRUS-REPLICATION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article C1 NCI,FREDERICK CANC RES FACIL,ABL,BASIC RES PROGRAM,FREDERICK,MD 21701. UNIV CALIF SAN DIEGO,SCH MED,SAN DIEGO,CA 92103. RP SADAIE, MR (reprint author), NCI,TUMOR CELL BIOL LAB,BLDG 37,ROOM 6A11,BETHESDA,MD 20892, USA. NR 39 TC 16 Z9 16 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1257 EP 1263 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000006 PM 2078407 ER PT J AU CIMINALE, V FELBER, BK CAMPBELL, M PAVLAKIS, GN AF CIMINALE, V FELBER, BK CAMPBELL, M PAVLAKIS, GN TI A BIOASSAY FOR HIV-1 BASED ON ENV-CD4 INTERACTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article C1 NCI,FREDERICK CANCER RES & DEV CTR,ABL BASIC RES PROGRAM,BLDG 539,ROOM 121,FREDERICK,MD 21702. FU NCI NIH HHS [N01-CO-74101] NR 41 TC 72 Z9 75 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1281 EP 1287 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000009 PM 2078409 ER PT J AU AOKI, S YARCHOAN, R THOMAS, RV PLUDA, JM MARCZYK, K BRODER, S MITSUYA, H AF AOKI, S YARCHOAN, R THOMAS, RV PLUDA, JM MARCZYK, K BRODER, S MITSUYA, H TI QUANTITATIVE-ANALYSIS OF HIV-1 PROVIRAL DNA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM PATIENTS WITH AIDS OR ARC - DECREASE OF PROVIRAL DNA CONTENT FOLLOWING TREATMENT WITH 2',3'-DIDEOXYINOSINE (DDI) SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article C1 NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,BLDG 10,ROOM 13N248,9000 ROCKVILLE PIKE,BETHESDA,MD 20892. NR 29 TC 68 Z9 68 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1331 EP 1339 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000015 PM 2127682 ER PT J AU JAMES, SL AF JAMES, SL TI VACCINE PROSPECTS FOR HUMAN PARASITES OTHER THAN MALARIA SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NIAID,DIV MICROBIOL & INFECT DIS,PARASITOL & TROP DIS BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1354 EP 1355 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000036 ER PT J AU ROBBINS, JB AF ROBBINS, JB TI PERTUSSIS TOXIN NEUTRALIZING ANTIBODIES (ANTITOXIN) FOR PREVENTION OF WHOOPING-COUGH SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1354 EP 1354 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000034 ER PT J AU FRANCHINI, G ROBERTGUROFF, M MARKHAM, P VERONESE, F GALLO, RC AF FRANCHINI, G ROBERTGUROFF, M MARKHAM, P VERONESE, F GALLO, RC TI EVALUATION OF HIV-2 IN RHESUS MACAQUES AS AN ANIMAL-MODEL FOR AN AIDS VACCINE SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. ADV BIOSCI LABS INC,KENSINGTON,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1357 EP 1358 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000049 ER PT J AU FAUCI, AS AF FAUCI, AS TI IMMUNOPATHOGENIC MECHANISMS OF HIV-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1358 EP 1359 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000053 ER PT J AU GIRARD, M KIENY, MP NARA, P BARRESINOUSSI, F PINTER, A RONCO, J MULLINS, J MUCHMORE, E CHAPUT, A KACZOREK, M FULTZ, P AF GIRARD, M KIENY, MP NARA, P BARRESINOUSSI, F PINTER, A RONCO, J MULLINS, J MUCHMORE, E CHAPUT, A KACZOREK, M FULTZ, P TI PROTECTIVE IMMUNITY AGAINST HIV IN CHIMPANZEES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 PASTEUR MERIEUX SERUMS & VACCINS,VAL DE REUIL,FRANCE. INST PASTEUR,F-75724 PARIS 15,FRANCE. TRANSGENE SA,STRASBOURG,FRANCE. NCI,FREDERICK,MD 21701. PUBL HLTH RES INST CITY NEW YORK INC,NEW YORK,NY 10016. STANFORD MED CTR,STANFORD,CA 94305. UNIV ALABAMA,BIRMINGHAM,AL 35294. NYU MED CTR,LEMSIP,NEW YORK,NY 10016. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1359 EP 1359 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000055 ER PT J AU KANNEL, WB ZHANG, TJ GARRISON, RJ AF KANNEL, WB ZHANG, TJ GARRISON, RJ TI IS OBESITY-RELATED HYPERTENSION LESS OF A CARDIOVASCULAR RISK - THE FRAMINGHAM-STUDY SO AMERICAN HEART JOURNAL LA English DT Article C1 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,EPIDEMIOL & BIOMETRY PROGRAM,BETHESDA,MD 20892. BOSTON UNIV,SCH MED,PREVENT MED & EPIDEMIOL SECT,BOSTON,MA 02118. BOSTON UNIV HOSP,MED CTR,EVANS MEM DEPT CLIN RES,BOSTON,MA 02218. FU NHLBI NIH HHS [N01-HC-38038, N01-HV-52971, N01-HV-92922] NR 50 TC 42 Z9 42 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD NOV PY 1990 VL 120 IS 5 BP 1195 EP 1201 DI 10.1016/0002-8703(90)90136-L PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EG257 UT WOS:A1990EG25700025 PM 2239671 ER PT J AU ROBERTS, CS GOTTDIENER, JS ROBERTS, WC AF ROBERTS, CS GOTTDIENER, JS ROBERTS, WC TI CLINICALLY UNDETECTED CARDIAC LYMPHOMA CAUSING FATAL CONGESTIVE-HEART-FAILURE SO AMERICAN HEART JOURNAL LA English DT Note C1 NHLBI,SURG BRANCH,BLDG 10,ROOM 2N258,BETHESDA,MD 20892. NHLBI,PATHOL BRANCH,BETHESDA,MD 20892. NHLBI,CARDIOL BRANCH,BETHESDA,MD 20892. NR 13 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD NOV PY 1990 VL 120 IS 5 BP 1239 EP 1242 DI 10.1016/0002-8703(90)90150-V PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EG257 UT WOS:A1990EG25700039 PM 2239684 ER PT J AU KNEKT, P ALBANES, D SEPPANEN, R AROMAA, A JARVINEN, R HYVONEN, L TEPPO, L PUKKALA, E AF KNEKT, P ALBANES, D SEPPANEN, R AROMAA, A JARVINEN, R HYVONEN, L TEPPO, L PUKKALA, E TI DIETARY-FAT AND RISK OF BREAST-CANCER SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article C1 UNIV HELSINKI,DEPT FOOD CHEM & TECHNOL,SF-00100 HELSINKI 10,FINLAND. NCI,BETHESDA,MD 20892. NATL PUBL HLTH INST,SF-00280 HELSINKI 28,FINLAND. FINNISH CANC REGISTRY,HELSINKI,FINLAND. RP KNEKT, P (reprint author), SOCIAL INSURANCE INST,RES INST SOCIAL SECUR,POB 78,SF-00381 HELSINKI,FINLAND. RI Albanes, Demetrius/B-9749-2015 NR 46 TC 86 Z9 87 U1 1 U2 2 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV PY 1990 VL 52 IS 5 BP 903 EP 908 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EF095 UT WOS:A1990EF09500022 PM 2239766 ER PT J AU BOUCHARD, C BRAY, GA HUBBARD, VS AF BOUCHARD, C BRAY, GA HUBBARD, VS TI BASIC AND CLINICAL ASPECTS OF REGIONAL FAT DISTRIBUTION SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Editorial Material C1 NIDDKD,EATING DISORDERS & ENERGY REGULAT PROGRAMS,WESTWOOD BLDG,ROOM 3A18B,BETHESDA,MD 20892. LAVAL UNIV,PHYS ACT SCI LAB,ST FOY,QUEBEC,CANADA. LOUISIANA STATE UNIV,PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70803. RI Bouchard, Claude/A-7637-2009 NR 0 TC 164 Z9 166 U1 0 U2 2 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV PY 1990 VL 52 IS 5 BP 946 EP 950 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EF095 UT WOS:A1990EF09500030 PM 2239774 ER PT J AU SORLIE, PD ROGOT, E AF SORLIE, PD ROGOT, E TI MORTALITY BY EMPLOYMENT STATUS IN THE NATIONAL-LONGITUDINAL-MORTALITY-STUDY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article RP SORLIE, PD (reprint author), NHLBI,EPIDEMIOL & BIOMETRY PROGRAM,FED BLDG,ROOM 3A10,7550 WISCONSIN AVE,BETHESDA,MD 20892, USA. NR 16 TC 59 Z9 59 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD NOV PY 1990 VL 132 IS 5 BP 983 EP 992 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EG027 UT WOS:A1990EG02700017 PM 2239913 ER PT J AU HARTMAN, AM BROWN, CC PALMGREN, J PIETINEN, P VERKASALO, M MYER, D VIRTAMO, J AF HARTMAN, AM BROWN, CC PALMGREN, J PIETINEN, P VERKASALO, M MYER, D VIRTAMO, J TI VARIABILITY IN NUTRIENT AND FOOD INTAKES AMONG OLDER MIDDLE-AGED MEN - IMPLICATIONS FOR DESIGN OF EPIDEMIOLOGIC AND VALIDATION STUDIES USING FOOD RECORDING SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article C1 NATL PUBL HLTH INST,SF-00280 HELSINKI 28,FINLAND. RP HARTMAN, AM (reprint author), NCI,DIV CANC PREVENT & CONTROL,EXECUT PLAZA N,ROOM 313F,BETHESDA,MD 20892, USA. OI Palmgren, Juni/0000-0002-9031-8615 FU NCI NIH HHS [N01-CN-45165] NR 55 TC 111 Z9 113 U1 4 U2 16 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD NOV PY 1990 VL 132 IS 5 BP 999 EP 1012 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EG027 UT WOS:A1990EG02700019 PM 2239915 ER PT J AU WACHOLDER, S SILVERMAN, DT AF WACHOLDER, S SILVERMAN, DT TI CASE-CONTROL STUDIES USING OTHER DISEASES AS CONTROLS - PROBLEMS OF EXCLUDING EXPOSURE-RELATED DISEASES SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter RP WACHOLDER, S (reprint author), NCI,BIOSTAT BRANCH,BETHESDA,MD 20892, USA. NR 4 TC 8 Z9 8 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD NOV PY 1990 VL 132 IS 5 BP 1017 EP 1018 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EG027 UT WOS:A1990EG02700023 PM 2239896 ER PT J AU AMOS, CI DAWSON, DV ELSTON, RC AF AMOS, CI DAWSON, DV ELSTON, RC TI THE PROBABILISTIC DETERMINATION OF IDENTITY-BY-DESCENT SHARING FOR PAIRS OF RELATIVES FROM PEDIGREES SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article C1 HOWARD UNIV,CTR CANC,DIV BIOSTAT & EPIDEMIOL,WASHINGTON,DC 20059. DUKE UNIV,MED CTR,DEPT COMMUNITY & FAMILY MED,DIV BIOMETRY & MED INFORMAT,DURHAM,NC 27710. LOUISIANA STATE UNIV,MED CTR,DEPT BIOMETRY & GENET,NEW ORLEANS,LA 70112. RP AMOS, CI (reprint author), NCI,FAMILY STUDIES SECT,6130 EXECUT BLVD,SUITE 439,BETHESDA,MD 20892, USA. FU NCI NIH HHS [CA14718]; NIGMS NIH HHS [GM39573, GM28356] NR 25 TC 43 Z9 44 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD NOV PY 1990 VL 47 IS 5 BP 842 EP 853 PG 12 WC Genetics & Heredity SC Genetics & Heredity GA EE940 UT WOS:A1990EE94000012 PM 2220824 ER PT J AU PROIA, RL KOLODNY, EH NAVON, R AF PROIA, RL KOLODNY, EH NAVON, R TI HEXOSAMINIDASE PSEUDODEFICIENCY - REPLY SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Letter C1 EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,WALTHAM,MA. TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN GENET,TEL AVIV,ISRAEL. SAPHIR MED CTR,MOLEC GENET UNIT,KFAR SABA,ISRAEL. RP PROIA, RL (reprint author), NIDDKD,GENET & BIOCHEM BRANCH,BETHESDA,MD, USA. RI Proia, Richard/A-7908-2012 NR 8 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD NOV PY 1990 VL 47 IS 5 BP 881 EP 882 PG 2 WC Genetics & Heredity SC Genetics & Heredity GA EE940 UT WOS:A1990EE94000019 ER PT J AU SAAVEDRA, JM PINTO, JEB FLUGGE, G TORDA, T AF SAAVEDRA, JM PINTO, JEB FLUGGE, G TORDA, T TI INCREASED BETA-2-ADRENOCEPTOR NUMBER IN PERIPHERAL SYMPATHETIC-GANGLIA OF SPONTANEOUSLY HYPERTENSIVE RATS SO AMERICAN JOURNAL OF HYPERTENSION LA English DT Article RP SAAVEDRA, JM (reprint author), NIMH,PHARMACOL SECT,CLIN SCI LAB,900 ROCKVILLE PIKE,BLDG 10,ROOM 2D-45,BETHESDA,MD 20892, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0895-7061 J9 AM J HYPERTENS JI Am. J. Hypertens. PD NOV PY 1990 VL 3 IS 11 BP 886 EP 889 PG 4 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EJ797 UT WOS:A1990EJ79700015 PM 2175628 ER PT J AU STRAUS, SE AF STRAUS, SE TI INTRAVENOUS IMMUNOGLOBULIN TREATMENT FOR THE CHRONIC FATIGUE SYNDROME SO AMERICAN JOURNAL OF MEDICINE LA English DT Editorial Material RP STRAUS, SE (reprint author), NIAID,CLIN INVEST LAB,MED VIROL SECT,BLDG 10,ROOM 11N113,BETHESDA,MD 20892, USA. NR 18 TC 20 Z9 20 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD NOV PY 1990 VL 89 IS 5 BP 551 EP 553 DI 10.1016/0002-9343(90)90171-9 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA EG936 UT WOS:A1990EG93600001 PM 2239974 ER PT J AU DICHIRO, G AF DICHIRO, G TI FOIX-ALAJOUANINE SYNDROME SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Letter RP DICHIRO, G (reprint author), NIH,BETHESDA,MD 20892, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD NOV-DEC PY 1990 VL 11 IS 6 BP 1286 EP 1286 PG 1 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA EG424 UT WOS:A1990EG42400058 PM 2124080 ER PT J AU BARRICK, B AF BARRICK, B TI LIGHT AT THE END OF A DECADE SO AMERICAN JOURNAL OF NURSING LA English DT Article RP BARRICK, B (reprint author), NIAID,WARREN GRANT MAGNUSEN CLIN CTR,BETHESDA,MD 20892, USA. NR 37 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD NOV PY 1990 VL 90 IS 11 BP 37 EP 40 PG 4 WC Nursing SC Nursing GA EG938 UT WOS:A1990EG93800018 ER PT J AU KLEBANOFF, MA SHIONO, PH CAREY, JC AF KLEBANOFF, MA SHIONO, PH CAREY, JC TI THE EFFECT OF PHYSICAL-ACTIVITY DURING PREGNANCY ON PRETERM DELIVERY AND BIRTH-WEIGHT SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article C1 UNIV OKLAHOMA,DEPT OBSTET & GYNECOL,OKLAHOMA CITY,OK. DAVID & LUCILE PACKARD FDN,CTR FUTURE CHILDREN,LOS ALTOS,CA. RP KLEBANOFF, MA (reprint author), NICHHD,DIV PREVENT RES,EPN 640,BETHESDA,MD 20892, USA. NR 10 TC 85 Z9 89 U1 0 U2 5 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD NOV PY 1990 VL 163 IS 5 BP 1450 EP 1456 PN 1 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA EJ614 UT WOS:A1990EJ61400006 PM 2240086 ER PT J AU MINKOFF, HL HENDERSON, C MENDEZ, H GAIL, MH HOLMAN, S WILLOUGHBY, A GOEDETT, JJ RUBINSTEIN, A STRATTON, P WALSH, JH LANDESMAN, SH AF MINKOFF, HL HENDERSON, C MENDEZ, H GAIL, MH HOLMAN, S WILLOUGHBY, A GOEDETT, JJ RUBINSTEIN, A STRATTON, P WALSH, JH LANDESMAN, SH TI PREGNANCY OUTCOMES AMONG MOTHERS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS AND UNINFECTED CONTROL SUBJECTS SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article C1 SUNY HLTH SCI CTR,DEPT PEDIAT,BROOKLYN,NY 11203. SUNY HLTH SCI CTR,DEPT INTERNAL MED,BROOKLYN,NY 11203. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL,BRONX,NY 10461. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461. NICHHD,DIV CHILDREN ADOLESCENTS & MOTHERS AIDS,BETHESDA,MD 20892. NCI,EPIDEMIOL METHODS SECT,BETHESDA,MD 20892. NCI,VIRAL EPIDEMIOL SECT,BETHESDA,MD 20892. WESTAT CORP,BETHESDA,MD. RP MINKOFF, HL (reprint author), SUNY HLTH SCI CTR,DEPT OBSTET & GYNECOL,BOX 24,450 CLARKSON AVE,BROOKLYN,NY 11203, USA. FU NCI NIH HHS [N01-CP-61013]; NCRR NIH HHS [RR00318] NR 13 TC 82 Z9 83 U1 1 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD NOV PY 1990 VL 163 IS 5 BP 1598 EP 1604 PN 1 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA EJ614 UT WOS:A1990EJ61400037 PM 2240112 ER PT J AU ZURLO, F LILLIOJA, S ESPOSITODELPUENTE, A NYOMBA, BL RAZ, I SAAD, MF SWINBURN, BA KNOWLER, WC BOGARDUS, C RAVUSSIN, E AF ZURLO, F LILLIOJA, S ESPOSITODELPUENTE, A NYOMBA, BL RAZ, I SAAD, MF SWINBURN, BA KNOWLER, WC BOGARDUS, C RAVUSSIN, E TI LOW RATIO OF FAT TO CARBOHYDRATE OXIDATION AS PREDICTOR OF WEIGHT-GAIN - STUDY OF 24-H RQ SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article C1 NIDDKD,CLIN DIABET & NUTR SECT,4212 N 16TH ST,RM 541,PHOENIX,AZ 85014. NIDDKD,DIABET & ARTHRITIS & EPIDEMIOL SECT,PHOENIX,AZ 85014. RI Lillioja, Stephen/A-8185-2012 NR 32 TC 363 Z9 372 U1 7 U2 26 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1990 VL 259 IS 5 BP E650 EP E657 PN 1 PG 8 WC Physiology SC Physiology GA EJ481 UT WOS:A1990EJ48100025 PM 2240203 ER PT J AU MORIYAMA, T GARCIAPEREZ, A BURG, MB AF MORIYAMA, T GARCIAPEREZ, A BURG, MB TI FACTORS AFFECTING THE RATIO OF DIFFERENT ORGANIC OSMOLYTES IN RENAL MEDULLARY CELLS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PAP-HT25 CELLS; SORBITOL; INOSITOL; GLYCEROPHOSPHORYLCHOLINE; BETAINE; HYPERTONIC SODIUM CHLORIDE; UREA ID ALDOSE REDUCTASE; INNER MEDULLA; MYOINOSITOL METABOLISM; EXTRACELLULAR NACL; HIGH GLUCOSE; ANTIDIURESIS; ACCUMULATION; TRANSPORT; SORBITOL; SOLUTES AB Renal medullary cells contain high concentrations of sorbitol, inositol, glycerophosphorylcholine (GPC), and betaine, which balance the variably high osmolality of extracellular NaCl. We found that PAP-HT25 (rabbit renal medullary) cells in tissue culture increase their content of all four when medium osmolality is increased by adding NaCl and urea. However, this requires that betaine be added to medium in addition to customary constituents. Some factors affecting the mix of organic osmolytes in these cells during hypertonicity are as follows. 1) Urea in medium increases cell GPC and tends to decrease others, particularly betaine. 2) With small increases in medium NaCl, intracellular inositol is highest, whereas sorbitol predominates with large NaCl increases. 3) When osmolality is suddenly decreased, these four organic osmolytes exit rapidly from cells, but in differing relative amounts (betaine >> sorbitol > inositol >> GPC). 4) Altering cell betaine levels (by varying betaine in medium) causes reciprocal changes in cell sorbitol (by affecting aldose reductase activity) and vice versa, whereas inositol and GPC are less affected. 5) Raising medium glucose concentration (from which sorbitol is synthesized) increases cell sorbitol and decreases cell inositol and betaine. 6) Decreasing the amount of GPC in cells (by removing choline from medium) causes small changes in betaine and sorbitol, but not in inositol. Changing the amount of inositol does not affect the others. Similar interrelations may operate in vivo to vary the mix of organic osmolytes in renal medulla. C1 NHLBI,KIDNEY & ELECTROLYTE METAB LAB,BLDG 10,RM 6N307,BETHESDA,MD 20892. NR 43 TC 72 Z9 72 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1990 VL 259 IS 5 BP F847 EP F858 PN 2 PG 12 WC Physiology SC Physiology GA ET375 UT WOS:A1990ET37500090 PM 2240234 ER PT J AU COX, KL VONSCHRENCK, T MORAN, TH GARDNER, JD JENSEN, RT AF COX, KL VONSCHRENCK, T MORAN, TH GARDNER, JD JENSEN, RT TI CHARACTERIZATION OF CHOLECYSTOKININ RECEPTORS ON THE SPHINCTER OF ODDI SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article C1 NIDDKD, DIGEST DIS BRANCH, BLDG 10, ROOM 9C-103, BETHESDA, MD 20892 USA. MED RES INST SAN FRANCISCO, SAN FRANCISCO, CA 94115 USA. JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT & BEHAV SCI, BALTIMORE, MD 21205 USA. FU NIDDK NIH HHS [DK-19302] NR 39 TC 18 Z9 18 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1990 VL 259 IS 5 BP G873 EP G881 PN 1 PG 9 WC Physiology SC Physiology GA EJ481 UT WOS:A1990EJ48100063 PM 2240227 ER PT J AU NATANSON, C DANNER, RL REILLY, JM DOERFLER, ML HOFFMAN, WD AKIN, GL HOSSEINI, JM BANKS, SM ELIN, RJ MACVITTIE, TJ PARRILLO, JE AF NATANSON, C DANNER, RL REILLY, JM DOERFLER, ML HOFFMAN, WD AKIN, GL HOSSEINI, JM BANKS, SM ELIN, RJ MACVITTIE, TJ PARRILLO, JE TI ANTIBIOTICS VERSUS CARDIOVASCULAR SUPPORT IN A CANINE MODEL OF HUMAN SEPTIC SHOCK SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE RANDOMIZED CONTROLLED TRIAL; DOPAMINE AND FLUIDS; GENTAMICIN AND CEFOXITIN; ANTIBIOTICS AND ENDOTOXEMIA ID NEGATIVE BACTERIAL SEPSIS; ESCHERICHIA-COLI; BACTEREMIA; CHALLENGES; ENDOTOXIN; THERAPY; AGGREGATION; PERFORMANCE; DYSFUNCTION; DEPRESSION AB This study compares the efficacy of antibiotics (cefoxitin and gentamicin), cardiovascular support (fluids and dopamine titrated by intravascular monitoring to hemodynamic end points), and a combination of these two therapies in dogs with septic shock induced by an intraperitoneal clot containing Escherichia coli. Survival rates were 0, 13, 13, and 43% in groups receiving no therapy (controls), antibiotics alone, cardiovascular support alone, or combined therapy (P < 0.01), respectively. The improved survival observed in the group receiving combined therapy considerably exceeded that in the groups receiving either therapy alone (i.e., a synergistic increase P < 0.05). Compared with antibiotics alone, cardiovascular support alone prolonged survival time (P < 0.006). All groups developed similar and significant (P < 0.01) increases in endotoxin levels; however, in the combined therapy group, nonsurvivors (compared with survivors) had higher levels of endotoxemia (P < 0.05). Although survivors and nonsurvivors in the combined therapy group required similar (P = 0.10) quantities of fluid therapy, nonsurvivors gained more weight (P < 0.05), suggesting abnormal vascular permeability with extravascular retention of fluids in the nonsurvivors. This study demonstrates that antibiotics alone and cardiovascular support alone are relatively ineffective in the treatment of septic shock. When combined, however, these two therapies provide moderately successful treatment for this highly lethal disorder. C1 DEF NUCL AGCY,ARMED FORCES RADIOBIOL RES INST,BETHESDA,MD 20814. RP NATANSON, C (reprint author), NIH,DEPT CRIT CARE MED,BLDG 10,ROOM 10D48,BETHESDA,MD 20892, USA. NR 32 TC 75 Z9 75 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1990 VL 259 IS 5 BP H1440 EP H1447 PN 2 PG 8 WC Physiology SC Physiology GA ET375 UT WOS:A1990ET37500019 ER PT J AU HOFFMAN, A GROSSMAN, E KEISER, HR AF HOFFMAN, A GROSSMAN, E KEISER, HR TI ROLE OF ATRIAL APPENDAGES IN MODULATING STIMULATED PLASMA ATRIAL-NATRIURETIC-PEPTIDE LEVELS IN CONSCIOUS RATS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE VOLUME EXPANSION; SALT LOAD; NOREPINEPHRINE; DEOXYCORTICOSTERONE ACETATE; CONGESTIVE HEART FAILURE; ARTERIOVENOUS FISTULA; ATRIAL APPENDECTOMY ID CONGESTIVE HEART-FAILURE; MINERALOCORTICOID ESCAPE; VOLUME-EXPANSION; RENAL RESPONSE; RELEASE; APPENDECTOMY; SECRETION; DOGS; ANF AB To evaluate the role of the atrial appendages in modulating plasma levels of atrial natriuretic peptide (ANP), we applied a series of both acute and chronic stimuli in conscious, chronic, bilaterally atrial-appendectomized (APP) and sham-operated control rats. Basal plasma ANP levels and urinary sodium excretion were normal in all rats after APP. The release of ANP was markedly blunted to acute volume expansion (+67% vs. +357% in controls, P < 0.01) but was only moderately reduced after norepinephrine infusion (+106% vs. +212%, P < 0.05) and was normal after acute salt load [+148% vs. +180% in controls, not significant (NS)]. Furthermore, plasma levels of ANP were increased normally in APP rats treated with deoxycorticosterone acetate (270 + 18 vs. 296 + 14 pg/ml in controls, NS) and in APP rats with congestive heart failure induced by a large arteriovenous (a-v) fistula between the aorta and the vena cava (306 +/- 18 vs. 302 +/- 12 pg/ml, NS). Sodium excretion patterns were similar in chronically stimulated APP and control rats. The results demonstrate that, although APP reduces the response of ANP release to acute volume expansion, it does not do so to other stimuli of either acute or chronic nature, suggesting that there is no permanent defect in the ability of APP rats to secrete ANP. These studies confirm that the atria are the major source for ANP release into the circulation after acute intravascular volume expansion. However, other tissue sources may contribute significantly to the levels of circulating ANP in response to this and other acute and chronic stimuli. RP HOFFMAN, A (reprint author), NHLBI,HYPERTENS ENDOCRINE BRANCH,BLDG 10,ROOM 8C103,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 35 TC 6 Z9 6 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1990 VL 259 IS 5 BP R1017 EP R1024 PN 2 PG 8 WC Physiology SC Physiology GA ET375 UT WOS:A1990ET37500063 ER PT J AU HASIN, DS GRANT, B ENDICOTT, J AF HASIN, DS GRANT, B ENDICOTT, J TI THE NATURAL-HISTORY OF ALCOHOL-ABUSE - IMPLICATIONS FOR DEFINITIONS OF ALCOHOL-USE DISORDERS SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article C1 NIAAA,WASHINGTON,DC. COLUMBIA UNIV COLL PHYS & SURG,NEW YORK,NY 10032. COLUMBIA UNIV,SCH PUBL HLTH,NEW YORK,NY 10027. FU NIMH NIH HHS [MH-30906] NR 15 TC 121 Z9 121 U1 1 U2 1 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD NOV PY 1990 VL 147 IS 11 BP 1537 EP 1541 PG 5 WC Psychiatry SC Psychiatry GA EF658 UT WOS:A1990EF65800019 PM 2221170 ER PT J AU SUBAR, AF HARLAN, LC MATTSON, ME AF SUBAR, AF HARLAN, LC MATTSON, ME TI FOOD AND NUTRIENT INTAKE DIFFERENCES BETWEEN SMOKERS AND NONSMOKERS IN THE UNITED-STATES SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article RP SUBAR, AF (reprint author), NCI,DIV CANC PREVENT & CONTROL,9000 ROCKVILLE PIKE,EXECUT PLAZA N 313,BETHESDA,MD 20892, USA. NR 62 TC 188 Z9 194 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 1990 VL 80 IS 11 BP 1323 EP 1329 DI 10.2105/AJPH.80.11.1323 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EF801 UT WOS:A1990EF80100008 PM 2240298 ER PT J AU PINSKY, JL JETTE, AM BRANCH, LG KANNEL, WB FEINLEIB, M AF PINSKY, JL JETTE, AM BRANCH, LG KANNEL, WB FEINLEIB, M TI THE FRAMINGHAM DISABILITY STUDY - RELATIONSHIP OF VARIOUS CORONARY HEART-DISEASE MANIFESTATIONS TO DISABILITY IN OLDER PERSONS LIVING IN THE COMMUNITY SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article C1 MASSACHUSETTS GEN HOSP,INST HLTH PROFESS,BOSTON,MA 02114. BOSTON UNIV,CTR GERONTOL,BOSTON,MA 02215. BOSTON UNIV,SCH MED,DEPT MED,PREVENT MED & EPIDEMIOL SECT,BOSTON,MA 02118. NATL CTR HLTH STAT,HYATTSVILLE,MD 20782. RP PINSKY, JL (reprint author), NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,FED BLDG,RM 2C08,BETHESDA,MD 20892, USA. FU NHLBI NIH HHS [N01HV52971] NR 17 TC 129 Z9 131 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 1990 VL 80 IS 11 BP 1363 EP 1367 DI 10.2105/AJPH.80.11.1363 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EF801 UT WOS:A1990EF80100016 PM 2240306 ER PT J AU CURIEL, DT BUCHHAGEN, DL CHIBA, I DAMICO, D TAKAHASHI, T MINNA, JD AF CURIEL, DT BUCHHAGEN, DL CHIBA, I DAMICO, D TAKAHASHI, T MINNA, JD TI A CHEMICAL MISMATCH CLEAVAGE METHOD USEFUL FOR THE DETECTION OF POINT MUTATIONS IN THE P53 GENE IN LUNG-CANCER SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article C1 NCI,NCI USN,MED ONCOL BRANCH,DIV CANC TREATMENT,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,NATL NAVAL MED CTR,BETHESDA,MD 20814. RI Takahashi, Takashi/I-7262-2014 NR 41 TC 16 Z9 16 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1044-1549 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD NOV PY 1990 VL 3 IS 5 BP 405 EP 411 PG 7 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA EG486 UT WOS:A1990EG48600003 PM 2223098 ER PT J AU FRANK, JA LING, A PATRONAS, NJ CARRASQUILLO, JA HORVATH, K HICKEY, AM DWYER, AJ AF FRANK, JA LING, A PATRONAS, NJ CARRASQUILLO, JA HORVATH, K HICKEY, AM DWYER, AJ TI DETECTION OF MALIGNANT BONE-TUMORS - MR-IMAGING VS SCINTIGRAPHY SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 GEORGETOWN UNIV,MED CTR,DEPT RADIOL,WASHINGTON,DC 20007. NIH,DEPT NUCL MED,BETHESDA,MD 20892. RP FRANK, JA (reprint author), NIH,DEPT DIAGNOST RADIOL,BLDG 10,RM 1C660,BETHESDA,MD 20892, USA. RI Carrasquillo, Jorge/E-7120-2010; OI Carrasquillo, Jorge/0000-0002-8513-5734 NR 24 TC 98 Z9 107 U1 1 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 1990 VL 155 IS 5 BP 1043 EP 1048 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EE983 UT WOS:A1990EE98300022 PM 2120933 ER PT J AU ROM, WN VIJAYAN, VK CORNELIUS, MJ KUMARASWAMI, V PRABHAKAR, R OTTESEN, EA CRYSTAL, RG AF ROM, WN VIJAYAN, VK CORNELIUS, MJ KUMARASWAMI, V PRABHAKAR, R OTTESEN, EA CRYSTAL, RG TI PERSISTENT LOWER RESPIRATORY-TRACT INFLAMMATION ASSOCIATED WITH INTERSTITIAL LUNG-DISEASE IN PATIENTS WITH TROPICAL PULMONARY EOSINOPHILIA FOLLOWING CONVENTIONAL TREATMENT WITH DIETHYLCARBAMAZINE SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article C1 NHLBI,PULM BRANCH,BLDG 10,ROOM 6DO3,BETHESDA,MD 20892. NIAID,PARASIT DIS LAB,BETHESDA,MD 20892. INDIAN COUNCIL MED RES,TB RES CTR,MADRAS,INDIA. NR 36 TC 36 Z9 36 U1 0 U2 2 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD NOV PY 1990 VL 142 IS 5 BP 1088 EP 1092 PG 5 WC Respiratory System SC Respiratory System GA EG088 UT WOS:A1990EG08800020 PM 2173455 ER PT J AU HOLMES, MD BRANTLY, ML CRYSTAL, RG AF HOLMES, MD BRANTLY, ML CRYSTAL, RG TI MOLECULAR ANALYSIS OF THE HETEROGENEITY AMONG THE P-FAMILY OF ALPHA-1-ANTITRYPSIN ALLELES SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article C1 NHLBI,PULM BRANCH,BLDG 10,ROOM 6D03,BETHESDA,MD 20892. NR 50 TC 21 Z9 21 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD NOV PY 1990 VL 142 IS 5 BP 1185 EP 1192 PG 8 WC Respiratory System SC Respiratory System GA EG088 UT WOS:A1990EG08800039 PM 2240842 ER PT J AU KORN, EL GRAUBARD, BI AF KORN, EL GRAUBARD, BI TI SIMULTANEOUS TESTING OF REGRESSION-COEFFICIENTS WITH COMPLEX SURVEY DATA - USE OF BONFERRONI T STATISTICS SO AMERICAN STATISTICIAN LA English DT Article C1 NCI,BIOMETRY BRANCH,BETHESDA,MD 20892. RP KORN, EL (reprint author), NCI,BIOMET RES BRANCH,EXECUT PLAZA N,ROOM 739,BETHESDA,MD 20892, USA. NR 42 TC 82 Z9 82 U1 1 U2 3 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0003-1305 J9 AM STAT JI Am. Stat. PD NOV PY 1990 VL 44 IS 4 BP 270 EP 276 DI 10.2307/2684345 PG 7 WC Statistics & Probability SC Mathematics GA EF653 UT WOS:A1990EF65300003 ER PT J AU KORN, EL AF KORN, EL TI PROJECTING POWER FROM A PREVIOUS STUDY - MAXIMUM-LIKELIHOOD-ESTIMATION SO AMERICAN STATISTICIAN LA English DT Article RP KORN, EL (reprint author), NCI,BIOMETR RES BRANCH,EXECUT PLAZA N,ROOM 739,BETHESDA,MD 20892, USA. NR 12 TC 10 Z9 10 U1 0 U2 1 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0003-1305 J9 AM STAT JI Am. Stat. PD NOV PY 1990 VL 44 IS 4 BP 290 EP 292 DI 10.2307/2684350 PG 3 WC Statistics & Probability SC Mathematics GA EF653 UT WOS:A1990EF65300008 ER PT J AU LEVIN, IW LEWIS, EN AF LEVIN, IW LEWIS, EN TI FOURIER-TRANSFORM RAMAN-SPECTROSCOPY OF BIOLOGICAL-MATERIALS SO ANALYTICAL CHEMISTRY LA English DT Article C1 NIDDKD,MOLEC BIOPHYS SECT,BETHESDA,MD 20892. RP LEVIN, IW (reprint author), NIDDKD,CHEM PHYS,BETHESDA,MD 20892, USA. NR 15 TC 56 Z9 56 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD NOV 1 PY 1990 VL 62 IS 21 BP A1101 EP & PG 0 WC Chemistry, Analytical SC Chemistry GA EF161 UT WOS:A1990EF16100002 ER PT J AU NORTON, JA SHAWKER, TH DOPPMAN, JL MILLER, DL FRAKER, DL CROMACK, DT GORDEN, P JENSEN, RT AF NORTON, JA SHAWKER, TH DOPPMAN, JL MILLER, DL FRAKER, DL CROMACK, DT GORDEN, P JENSEN, RT TI LOCALIZATION AND SURGICAL-TREATMENT OF OCCULT INSULINOMAS SO ANNALS OF SURGERY LA English DT Article C1 NIDDKD,CTR CLIN,DEPT DIAGNOST RADIOL,BETHESDA,MD. NIDDKD,DIABET BRANCH,BETHESDA,MD. NIDDKD,DIGEST DIS BRANCH,BETHESDA,MD. RP NORTON, JA (reprint author), NCI,SURG BRANCH,SURG METAB SECT,BLDG 10,ROOM 2B07,BETHESDA,MD 20892, USA. NR 24 TC 135 Z9 142 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD NOV PY 1990 VL 212 IS 5 BP 615 EP 620 DI 10.1097/00000658-199011000-00009 PG 6 WC Surgery SC Surgery GA EG930 UT WOS:A1990EG93000009 PM 2241318 ER EF