FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU MULRONEY, SE
   HARAMATI, A
   WERNER, H
   BONDY, C
   ROBERTS, CT
   LEROITH, D
AF MULRONEY, SE
   HARAMATI, A
   WERNER, H
   BONDY, C
   ROBERTS, CT
   LEROITH, D
TI ALTERED EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF
   RECEPTOR GENES AFTER UNILATERAL NEPHRECTOMY IN IMMATURE RATS
SO ENDOCRINOLOGY
LA English
DT Article
ID GLOMERULAR-FILTRATION RATE; COMPENSATORY RENAL GROWTH; RIBONUCLEIC-ACID;
   TRANSGENIC MICE; MESSENGER-RNAS; SOMATOMEDIN-C; PLASMA-FLOW; KIDNEY;
   HYPERTROPHY; HORMONE
AB There is a developmental difference in the initial phase of compensatory renal growth (CRG) following unilateral nephrectomy (UNX), in that CRG is GH-dependent in adult rats and GH-independent in immature rats.  Furthermore, CRG in immature rats is associated with an increase in renal IGF-I mRNA, an effect not seen in adult rats.  In this study we have examined the age-related differences in expression of the insulin-like growth factor-I (IGF-I) and IGF-II genes as well as in IGF-I and IGF-II receptors and membrane binding after UNX.  Immature (22-24 days of age) and adult (4 months of age) male Wistar rats underwent a sham operation or left UNX and were killed 24 or 48 h later.  Levels of mRNA for IGF-I and IGF-II and their receptors were determined in the left (control) and right (compensated) remnant kidneys using solution hybridization/RNase protection assays.  Steady state levels of IGF-I mRNA as well as IGF-I receptor and IGF-II/mannose-6-phosphate receptor mRNAs were increased 3- to 4-fold in immature remnant kidneys, but not in adult kidneys.  The findings related to IGF-I gene expression were confirmed by in situ hybridization to immature and adult kidney slices.  The increase in IGF-I gene expression in the immature remnant kidneys was localized to the thick ascending limbs of the loops of Henle.  Furthermore, in concert with the changes in mRNA levels, membrane binding studies showed significant increases in specific binding to IGF-I in cortical membranes and increases in specific binding to IGF-II in whole kidney membranes from immature, but not adult, rats.  Thus, these findings demonstrate that the initial phase of CRG in the immature rat is associated with increased renal IGF-I gene expression as well as enhanced specific renal binding of IGF-I and IGF-II to plasma membranes and support the notion that this period of rapid renal growth in the immature UNX rat may involve the paracrine influence of the IGFs.
C1 NIDKDD,MOLEC & CELLULAR PHYSIOL SECT,BETHESDA,MD 20892.
   NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892.
RP MULRONEY, SE (reprint author), GEORGETOWN UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS,ROOM 256B,BASIC SCI BLDG,3900 RESERVOIR RD NW,WASHINGTON,DC 20007, USA.
FU NIDDK NIH HHS [DK-36111]
NR 38
TC 49
Z9 49
U1 0
U2 0
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 1992
VL 130
IS 1
BP 249
EP 256
DI 10.1210/en.130.1.249
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HH370
UT WOS:A1992HH37000035
PM 1309331
ER

PT J
AU HENDERSON, JE
   KREMER, R
   RHIM, JS
   GOLTZMAN, D
AF HENDERSON, JE
   KREMER, R
   RHIM, JS
   GOLTZMAN, D
TI IDENTIFICATION AND FUNCTIONAL-CHARACTERIZATION OF ADENYLATE
   CYCLASE-LINKED RECEPTORS FOR PARATHYROID HORMONE-LIKE PEPTIDES ON
   IMMORTALIZED HUMAN KERATINOCYTES
SO ENDOCRINOLOGY
LA English
DT Article
ID EPIDERMAL GROWTH-FACTOR; CELL-LINE UMR-106; NEOPLASTIC TRANSFORMATION;
   CYCLIC-AMP; SIGNAL TRANSDUCTION; SARCOMA-VIRUSES; RAS ONCOGENE;
   FACTOR-ALPHA; BONE-CELLS; BINDING
AB We have identified and characterized receptors for the amino-terminal domains of PTH and PTH-like peptide (PLP) on an immortalized human keratinocyte cell line, RHEK-1.  Binding of both PLP-(1-34) and PTH-(1-34) to the RHEK-1 cells was consistent with a two-site model; affinities and capacities for each site were similar for the two peptides.  Both peptides also stimulated adenylate cyclase activity with an equal ED50 in this cell line.  Pertussis toxin pretreatment enhanced this peptide-mediated enzyme activity, suggesting linkage of the receptor to an inhibitory guanyl nucleotide-binding protein (G(i)).  Adenylate cyclase activity was diminished by both homologous [PLP-(1-34)] and heterologous [epidermal growth factor (EGF)] effectors.  Malignant conversion of the immortalized cells with an activated H-ras oncogene to produce the RHEK-ras cell line was associated with a reduction in binding at both PLP/PTH and EGF receptors as well as a postreceptor defect in PLP/PTH-stimulated adenylate cyclase activity.  The defect in enzyme activity appeared to be due in part to a decrease in the activity of the stimulatory guanyl nucleotide-binding protein (G(s)), but not to an increase in G(i) activity.  Activation of the keratinocyte amino-terminal PLP/PTH receptor resulted in a small increase in [H-3]thymidine incorporation, which was associated with an increase in cell numbers.  This mitogenic effect was enhanced in the presence of EGF and was markedly reduced when cells were cultured in a high extracellular calcium environment.  These studies demonstrate that the amino-terminal region of PLP and PTH activates adenylate cyclase-linked receptors, which are associated with mitogenesis, in RHEK-1 cells and suggest that this cell line represents a suitable model in which to examine the actions of PLP in keratinocytes.
C1 MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA.
   MCGILL UNIV,DEPT PHYSIOL,MONTREAL H3A 2T5,QUEBEC,CANADA.
   NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 49
TC 41
Z9 42
U1 0
U2 0
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 1992
VL 130
IS 1
BP 449
EP 457
DI 10.1210/en.130.1.449
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HH370
UT WOS:A1992HH37000061
PM 1309343
ER

PT J
AU STOJILKOVIC, SS
   BALLA, T
   FUKUDA, S
   CESNJAJ, M
   MERELLI, F
   KRSMANOVIC, LZ
   CATT, KJ
AF STOJILKOVIC, SS
   BALLA, T
   FUKUDA, S
   CESNJAJ, M
   MERELLI, F
   KRSMANOVIC, LZ
   CATT, KJ
TI ENDOTHELIN ETA RECEPTORS MEDIATE THE SIGNALING AND SECRETORY ACTIONS OF
   ENDOTHELINS IN PITUITARY GONADOTROPHS
SO ENDOCRINOLOGY
LA English
DT Article
ID VASCULAR SMOOTH-MUSCLE; ADRENAL GLOMERULOSA CELLS; PHOSPHATIDYLINOSITOL
   HYDROLYSIS; VASOCONSTRICTOR ENDOTHELIN; INOSITOL TRISPHOSPHATE; RAT
   HYPOTHALAMUS; ANGIOTENSIN-II; CALCIUM; BRAIN; RELEASE
AB Specific receptors for endothelin (ET), localized by autoradiographic studies with [I-125]ET in frozen sections of the rat pituitary gland, were abundant in the adenohypophysis, but not in the neurohypophysis.  Specific binding of [I-125]ET-1 and [I-125]ET-3 was also demonstrable in 3-day-old primary cultures of anterior pituitary cells.  The binding of [I-125]ET-1 to its receptors was time and temperature dependent and was followed by rapid internalization of the receptor-ligand complex.  Binding of [I-125]ET-1 and [I-125]ET-3 to pituitary tissues and cells was more effectively displaced by ET-1 and ET-2 than by ET-3.  In cultured pituitary cells, ET-1 caused a rapid increase in polyphosphoinositide hydrolysis, and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] production, with a prompt rise in the cytoplasmic calcium concentration ([Ca2+]i) and LH secretion.  The Ins(1,4,5)P3 response to 100 nM ET-1 was transient, with a spike at 10 sec followed by an exponential decrease toward the low steady state level.  Ins(1,3,4)P3 and inositol bisphosphate (InsP2) increased more slowly, reaching peak values 30-40 sec after stimulation.  The kinetics of the [Ca2+]i response to ET-1 were similar to those of the Ins(1,4,5)P3 response and more rapid than those of the Ins(1,3,4)P3 and InsP2 responses.  In perifused cells, ET-stimulated increases in LH release showed the same biphasic patterns as the Ins(1,4,5)P3 and [Ca2+]i responses.  ET-1 was more potent than ET-3 in stimulating [Ca2+]i and LH responses, consistent with its higher affinity for the pituitary ET receptors.  The initial activation of Ca2+ signaling and LH exocytosis by ETs was followed by prolonged refractoriness to both ET-1 and ET-3.  The development of desensitization occurred more rapidly in ET-1- than ET-3-stimulated cells and correlated temporally with endocytosis of the receptor-ligand complex.  These findings indicate that stimulation of gonadotropin release by ETs occurs via activation of ET(A)-type receptors, which are coupled to polyphosphoinositide hydrolysis and [Ca2+]i mobilization, and undergo rapid internalization and profound desensitization.
RP STOJILKOVIC, SS (reprint author), NICHHD,ENDOCRINOL & REPROD RES BRANCH,BLDG ROOM B1-L400,BETHESDA,MD 20892, USA.
OI Balla, Tamas/0000-0002-9077-3335
NR 39
TC 73
Z9 73
U1 1
U2 1
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 1992
VL 130
IS 1
BP 465
EP 474
DI 10.1210/en.130.1.465
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HH370
UT WOS:A1992HH37000063
PM 1309344
ER

PT J
AU SAJI, M
   AKAMIZU, T
   SANCHEZ, M
   OBICI, S
   AVVEDIMENTO, E
   GOTTESMAN, ME
   KOHN, LD
AF SAJI, M
   AKAMIZU, T
   SANCHEZ, M
   OBICI, S
   AVVEDIMENTO, E
   GOTTESMAN, ME
   KOHN, LD
TI REGULATION OF THYROTROPIN RECEPTOR GENE-EXPRESSION IN RAT FRTL-5
   THYROID-CELLS
SO ENDOCRINOLOGY
LA English
DT Article
ID GROWTH FACTOR-I; FOLLICLE-STIMULATING-HORMONE; THYROGLOBULIN GENE;
   GRANULOSA-CELLS; MESSENGER-RNA; SOMATOMEDIN-C; CYCLIC-AMP; CAMP;
   CULTURE; TRANSCRIPTION
AB TSH receptor mRNA levels in FRTL-5 thyroid cells are autoregulated at a transcriptional level by the same hormones required for the growth and function of the cells:  TSH, insulin, and insulin-like growth factor-I (IGF-I).  Thus, the ability of TSH, via its cAMP signal, to down-regulate steady state receptor mRNA levels is preceded by the action of TSH to decrease pre-mRNA levels in nuclear run-on assays to the same quantitative level as evident in Northern analyses.  In contrast, the receptor mRNA half-life is shown not to change when down-regulation is reversed by withdrawing TSH in the presence or absence of actinomycin-D.  Evidence is additionally provided that TSH receptor mRNA levels are increased by insulin, IGF-I, or calf serum in both Northern and run-on assays.  This action cannot be duplicated by hydrocortisone and is evident at more than 20-fold lower concentrations of IGF-I than insulin.  Moreover, insulin, IGF-I, and/or calf serum are required for the autoregulatory negative transcriptional regulation of the TSH receptor by TSH/cAMP, as is the case for thyroglobulin.  This occurs despite the opposite actions of TSH/cAMP on the two genes, positive in the case of thyroglobulin and negative with TSH receptor.  The positive and negative regulatory actions, respectively, of insulin/IGF-I and TSH on receptor gene expression are associated with coincident increases or decreases in cell surface receptors measured by [I-125]TSH binding.  The autoregulation additionally involves the interplay of a second cAMP-modulated regulatory factor, one which up-regulates TSH receptor mRNA levels rather than causing down-regulation.  Thus, cycloheximide inhibits the transcriptional action of both TSH/cAMP and insulin/IGF-I/serum within 4 h, i.e. a rapidly synthesized protein is an intermediate in both cases.  The presence of cycloheximide for as little as 1 h, however, uncovers the ability of TSH/cAMP to increase TSH receptor mRNA levels.  This activity is the result of the action of a stable cAMP-induced activator which can be detected physiologically, i.e. in the absence of cycloheximide.  For example, low levels of a cAMP analog (0.2 mM), as opposed to high levels (> 1 mM), can increase TSH receptor RNA levels.  Low levels also accelerate the insulin/IGF-I-dependent return of receptor mRNA to normal levels after TSH withdrawal.  The action of this positive regulator may also account for a transient increase in receptor mRNA levels before TSH/cAMP-induced down regulation is evident in Northern and run-on assays, i.e. within 1-2 h after TSH addition and maximal cAMP elevation.  Thus, in run-on assays, TSH increases transcription 1 h after its addition, but decreases transcription by 4 h.  The sum of the interplay of insulin, IGF-I, and TSH on TSH receptor gene expression appears, therefore, to be an interactive autoregulatory feedback mechanism to maintain TSH receptor activity on the cell surface.
C1 NIDKDD,DEPT BIOCHEM METAB,CELL REGULAT SECT,BIOCHEM & METAB LAB,BLDG 10,ROOM 9B13,BETHESDA,MD 20892.
   COLUMBIA UNIV,INST CANC RES,NEW YORK,NY 10032.
RI Saji, Motoyasu/E-4007-2011
FU PHS HHS [P-50-PK41146]
NR 46
TC 80
Z9 80
U1 0
U2 4
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 1992
VL 130
IS 1
BP 520
EP 533
DI 10.1210/en.130.1.520
PG 14
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HH370
UT WOS:A1992HH37000070
PM 1309347
ER

PT B
AU RAVUSSIN, E
   RISING, R
AF RAVUSSIN, E
   RISING, R
BE KINNEY, JM
   TUCKER, HN
TI DAILY ENERGY-EXPENDITURE IN HUMANS - MEASUREMENTS IN A RESPIRATORY
   CHAMBER AND BY DOUBLY LABELED WATER
SO ENERGY METABOLISM: TISSUE DETERMINANTS AND CELLULAR COROLLARIES
LA English
DT Proceedings Paper
CT 1ST CLINTEC INTERNATIONAL HORIZONS CONF ON ENERGY METABOLISM : TISSUE
   DETERMINANTS AND CELLULAR COROLLARIES
CY MAY 05-09, 1991
CL AMSTERDAM, NETHERLANDS
SP CLINTEC INT, CLINTEC NUTR
RP RAVUSSIN, E (reprint author), NIDDKD,CLIN DIABET & NUTR SECT,4212 N 6TH ST,PHOENIX,AZ 85016, USA.
NR 0
TC 18
Z9 18
U1 0
U2 0
PU RAVEN PRESS
PI NEW YORK
PA NEW YORK
BN 0-88167-871-6
PY 1992
BP 81
EP 96
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Nutrition
   & Dietetics; Physiology
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Nutrition
   & Dietetics; Physiology
GA BV48Q
UT WOS:A1992BV48Q00004
ER

PT J
AU DUNKEL, VC
   SAN, RHC
   HARBELL, JW
   SEIFRIED, HE
   CAMERON, TP
AF DUNKEL, VC
   SAN, RHC
   HARBELL, JW
   SEIFRIED, HE
   CAMERON, TP
TI EVALUATION OF THE MUTAGENICITY OF AN N-NITROSO CONTAMINANT OF THE
   SUNSCREEN PADIMATE-O - N-NITROSO-N-METHYL-PARA-AMINOBENZOIC ACID,
   2-ETHYLHEXYL ESTER (NPABAO)
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE SALMONELLA; MOUSE LYMPHOMA; MUTAGENICITY; SUNSCREENS; NITROSAMINE
ID SALMONELLA
AB The nitrosamine contaminant, N-nitroso-N-methyl-p-aminobenzoic acid, 2-ethylhexyl ester (NPABAO), of the major sunscreen ingredient Padimate O (4-N,N'-dimethylamino-benzoic acid, 2-ethylhexyl ester) was synthesized and tested for mutagenicity in the Salmonella typhimurium and mouse lymphoma L5178Y TK+/-assays. In contrast to the previously reported positive responses in S. typhimurium tester strains TA100 and TA1535 [Loeppky et al., 1991], there were no increases in the number of revertants with strains TA98, TA100, TA1535, and TA1538 in either the Salmonella plate incorporation [Ames et al., 1975] or preincubation [Yahagi et al., 1977] assays. Additional testing with Salmonella, following the modified preincubation procedure [Rogan, 1990] that gave the initial positive response, was also negative. Data from the mouse lymphoma assays were also uniformly negative.
   During synthesis of NPABAO, small amounts of 4-N,N'-dimethylamino-3-nitrobenzoic acid, 2-ethylhexyl ester (DMANBAO) can be formed. To determine whether the reported positive mutagenicity response.of NPABAO could be the result of trace amounts of DMANBAO in the NPABAO, that compound was also synthesized and tested for mutagenicity with Salmonella. Positive responses were obtained with tester strains TA98 and TA 1538 but not with TA100 and TA1535, indicating that DMANBAO was not responsible for the increase in revertants originally reported.
C1 NCI,EXECUT PLAZA N BLDG,RM 712,BETHESDA,MD 20892.
   US FDA,WASHINGTON,DC 20204.
   MICROBIOL ASSOCIATES INC,ROCKVILLE,MD.
NR 11
TC 7
Z9 7
U1 0
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 20
IS 3
BP 188
EP 198
DI 10.1002/em.2850200307
PG 11
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA JT903
UT WOS:A1992JT90300006
PM 1396609
ER

PT J
AU DILLON, D
   EDWARDS, I
   COMBES, R
   MCCONVILLE, M
   ZEIGER, E
AF DILLON, D
   EDWARDS, I
   COMBES, R
   MCCONVILLE, M
   ZEIGER, E
TI THE ROLE OF GLUTATHIONE IN THE BACTERIAL MUTAGENICITY OF VAPOR-PHASE
   DICHLOROMETHANE
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE CARCINOGEN; MUTAGEN; SALMONELLA; ESCHERICHIA-COLI
ID SALMONELLA-TYPHIMURIUM; METHYLENE-CHLORIDE; S-TRANSFERASES;
   METABOLIC-ACTIVATION; CHROMOSOME-DAMAGE; 42 CHEMICALS; CONJUGATION;
   MUTAGENESIS; DERIVATIVES; DEFICIENT
AB Dichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the conversion of DCM to a bacterial mutagen has been studied in a vapour phase protocol using wild-type and GSH-deficient (NG54; gsh) Salmonella typhimurium TA100 strains in the presence and absence of various rat liver fractions. The effect of the duration of exposure was also investigated in these Salmonella strains and in E. coli WP2 uvrA pKM101. Dose- and time-related increases in revertants occurred with all metabolic activation systems used (without exogenous metabolic activation; with Aroclor-induced rat liver S9, microsomes, or cytosol fractions), with minor quantitative differences among the 3 strains. Mutagenicity was marginally highest in the presence of cytosol at the highest DCM concentrations. Strain NG54 gsh, which contains approximately 25% of the TA100 level of GSH/mug protein, was slightly less responsive to DCM-induced mutagenicity than TA100. Addition of 0.33 mumoles/plate of GSH had little effect on the mutagenic responses of TA100 or NG54 in the presence or absence of S9. In these 2 strains, exogenous S9 produced small increases in mutagenicity at the highest concentrations of DCM (2 and 4% v/v). These results suggest that if an interaction between DCM and GSH is required for the activation of DCM to a bacterial mutagen, it occurs at low levels of endogenous GSH and is not significantly affected by GSH supplementation.
C1 NIEHS,RES TRIANGLE PK,NC 27709.
   INVERESK RES INT LTD,TRANENT,SCOTLAND.
FU NIEHS NIH HHS [N01-ES-55127]
NR 40
TC 9
Z9 9
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 20
IS 3
BP 211
EP 217
DI 10.1002/em.2850200310
PG 7
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA JT903
UT WOS:A1992JT90300009
PM 1396612
ER

PT J
AU MULLER, J
   JANZ, S
AF MULLER, J
   JANZ, S
TI ASSESSMENT OF OXIDATIVE DNA DAMAGE IN THE OXYR-DEFICIENT SOS CHROMOTEST
   STRAIN ESCHERICHIA-COLI PQ300
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE DNA REPAIR; SOS RESPONSE; OXIDATIVE DNA DAMAGE; SHORT-TERM BACTERIAL
   GENOTOXICITY ASSAY
ID ALKYL HYDROPEROXIDE REDUCTASE; COLORIMETRIC BACTERIAL ASSAY;
   TOPOISOMERASE-II INHIBITORS; HYDROXYL RADICAL GENERATION;
   SALMONELLA-TYPHIMURIUM; HYDROGEN-PEROXIDE; MONOFUNCTIONAL
   METHANESULFONATES; XANTHINE-OXIDASE; GENOTOXIC AGENTS; MITOMYCIN-C
AB The SOS chromotest is a simple short-term genotoxicity assay measuring the induction of gene sfiA in Escherichia coli K-12. The recent availability of SOS tester strains with additional mutations in DNA repair or protection systems allows testing of DNA damaging compounds for genotoxic specificity. E. coli PQ300 differs from the standard SOS tester strain PQ37 in that it contains an additional mutation in gene oxyR that renders it more sensitive to oxidative genotoxins. The generation of reactive oxygen intermediates (ROI) by hydroperoxides (H2O2, t-butyl hydroperoxide, cumene hydroperoxide), gamma-radiation, glucose oxidase, and xanthine oxidase resulted in a more vigorous SOS response in strain PQ300 compared to strain PQ37. PQ300 was also more sensitive than PQ37 for the detection of reducing agents such as ascorbic acid, cysteine, and glutathione, which also alter the redox status of the bacterial cells. However, intercalating agents (adriamycin, bleomycin, and mitomycin C) and the UV- and radiomimetic compound 4-nitroquinoline-1-oxide whose DNA damaging potential are known also to involve ROI did not show significant differences between strains PQ37 and PQ300. It is concluded that the oxyR-deficient strain PQ300 is useful for detecting certain classes of genotoxins that change the oxidative/antioxidative balance of tester bacteria in the SOS chromotest.
C1 NCI,GENET LAB,BLDG 37,RM 2B09,BETHESDA,MD 20892.
   UNIV LEIPZIG,FAC MED,INST CLIN IMMUNOL,O-7010 LEIPZIG,GERMANY.
NR 70
TC 9
Z9 9
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 20
IS 4
BP 297
EP 306
DI 10.1002/em.2850200408
PG 10
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA KA020
UT WOS:A1992KA02000007
PM 1425609
ER

PT J
AU ZEIGER, E
   ANDERSON, B
   HAWORTH, S
   LAWLOR, T
   MORTELMANS, K
AF ZEIGER, E
   ANDERSON, B
   HAWORTH, S
   LAWLOR, T
   MORTELMANS, K
TI SALMONELLA MUTAGENICITY TESTS .5. RESULTS FROM THE TESTING OF 311
   CHEMICALS
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE AMES TEST; NATIONAL TOXICOLOGY PROGRAM; MUTAGENICITY TESTING; SALMONELLA
ID ESCHERICHIA-COLI; REPRODUCIBILITY; TYPHIMURIUM; ASSAYS
AB 311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories.  The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters.  Some of the volatile chemicals were also tested in desiccators.  A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic.  The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested.  The results and data from these tests are presented.
C1 MICROBIOL ASSOCIATES INC,DEPT GENET TOXICOL,ROCKVILLE,MD.
   SRI INT,DEPT MICROBIAL GENET,MENLO PK,CA 94025.
RP ZEIGER, E (reprint author), NIEHS,EXPTL CARCINOGENESIS & MUTAGENESIS BRANCH,RES TRIANGLE PK,NC 27709, USA.
NR 12
TC 167
Z9 174
U1 1
U2 21
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 19
SU 21
BP 2
EP 141
DI 10.1002/em.2850190603
PG 140
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA HK483
UT WOS:A1992HK48300001
PM 1541260
ER

PT J
AU DEGRAFF, WG
   KRISHNA, MC
   RUSSO, A
   MITCHELL, JB
AF DEGRAFF, WG
   KRISHNA, MC
   RUSSO, A
   MITCHELL, JB
TI ANTIMUTAGENICITY OF A LOW-MOLECULAR-WEIGHT SUPEROXIDE-DISMUTASE MIMIC
   AGAINST OXIDATIVE MUTAGENS
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE HYDROGEN PEROXIDE; SUPEROXIDE; NITROXIDE; OXIDATIVE STRESS; PROTECTION
ID XANTHINE-OXIDASE SYSTEM; HYDROGEN-PEROXIDE; MAMMALIAN-CELLS; AS52 CELLS;
   CHO CELLS; MUTATIONS; RADIATION
AB A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (Tempol), was investigated for antimutagenic activity in the XPRT forward mutation assay in CHO AS52 cells. AS52 cells were exposed to hydrogen peroxide, or the hypoxanthine/xanthine oxidase superoxide generating system, in the presence or absence of 10 mM Tempol. Tempol itself was not mutagenic or toxic to AS52 cells. Tempol protected cells nearly completely from the cytotoxic and mutagenic effects of hydrogen peroxide and hypoxanthine/xanthine oxidase. We have previously shown that nitroxides do not alter the extracellular concentration of hydrogen peroxide, and that they are taken up by mammalian cells, suggesting that the antimutagenic activity of Tempol is an intracellular phenomenon.
RP DEGRAFF, WG (reprint author), NCI,RADIAT ONCOL BRANCH,RADIOBIOL SECT,BLDG 10,RM B3B69,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 22
TC 45
Z9 46
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 19
IS 1
BP 21
EP 26
DI 10.1002/em.2850190105
PG 6
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA GZ593
UT WOS:A1992GZ59300004
PM 1310080
ER

PT J
AU PAGANO, DA
   ZEIGER, E
AF PAGANO, DA
   ZEIGER, E
TI CONDITIONS FOR DETECTING THE MUTAGENICITY OF DIVALENT METALS IN
   SALMONELLA-TYPHIMURIUM
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE COBALT; IRON; MANGANESE; CADMIUM; ZINC; CHELATION
ID ESCHERICHIA-COLI; SUPEROXIDE-DISMUTASE; MAGNESIUM TRANSPORT; GENETIC
   TOXICOLOGY; CHEMICALS; CADMIUM; MUTAGENESIS; BACTERIA; OXYGEN; ASSAY
AB The mutagenesis of metals in bacteria, as reported in the literature, can best be described as inconsistent. We report that cobalt chloride (Co++), ferrous sulfate (Fe++), manganese sulfate (Mn++), cadmium chloride (Cd++), and zinc chloride (Zn++) could be reproducibly detected as mutagens in Salmonella strain TA97 when preincubation exposures were made in sterile, distilled, deionized water, or in Hepes buffer in NaCl2/KCl2, rather than the standard sodium phosphate buffer. Co++ was also mutagenic under standard preincubation conditions. The individual components of Vogel-Bonner medium, i.e., potassium and ammonium phosphates, citrate, and magnesium sulfate, inhibit mutagenesis by these metals. The phosphates and the citrate probably inhibit by chelating the metals, while data are presented to suggest that Mg++ inhibition of metal mutagenesis is due to competitive inhibition for active transport via the magnesium active transport system in Salmonella. The chelator, diethyldithiocarbamate, inhibited the mutagenicity of Co++, Fe++, Zn++ and Mn++, but enhanced the mutagenicity of Cd++. The results presented show that divalent metals can be detected as mutagens in Salmonella, and that their lock of detection as mutagens is not due to an inherent insensitivity of Salmonella but to their interaction with media components and/or passive and active transport processes.
C1 NIEHS,EXPTL TOXICOL BRANCH,RES TRIANGLE PK,NC 27709.
NR 38
TC 45
Z9 45
U1 0
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 19
IS 2
BP 139
EP 146
DI 10.1002/em.2850190208
PG 8
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA HH531
UT WOS:A1992HH53100007
PM 1541255
ER

PT J
AU MASON, JM
   VALENCIA, R
   ZIMMERING, S
AF MASON, JM
   VALENCIA, R
   ZIMMERING, S
TI CHEMICAL MUTAGENESIS TESTING IN DROSOPHILA .8. REEXAMINATION OF
   EQUIVOCAL RESULTS
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE DROSOPHILA-MELANOGASTER; CHEMICAL MUTAGENESIS; SEX-LINKED RECESSIVE
   LETHALS; STATISTICAL ANALYSIS; CONTROLS
ID NATIONAL-TOXICOLOGY-PROGRAM
AB Twelve percent of the chemicals tested for mutagenicity by the National Toxicology Program (NTP) using the Drosophila sex-linked recessive lethal assay have been classified as producing equivocal results. We have reexamined the published data and the criteria used to determine mutagenicity in light of the historical distribution of the concurrent negative controls for this project. Many of the chemicals that originally produced equivocal results have been retested under code. As a result of changes to incorporate a comparison with the historical control in the algorithm used to determine mutagenicity and as a result of new data accumulated, 4 of the 25 chemicals that gave equivocal results are judged to be mutagenic, and 11 others are judged to be nonmutagenic under our test conditions.
C1 UNIV WISCONSIN,DEPT ZOOL,MADISON,WI 53706.
   BROWN UNIV,DIV BIOL & MED,PROVIDENCE,RI 02912.
RP MASON, JM (reprint author), NIEHS,EXPTL CARCINOGENESIS & MUTAGENESIS BRANCH,POB 12233,RES TRIANGLE PK,NC 27709, USA.
NR 19
TC 10
Z9 10
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 19
IS 3
BP 227
EP 234
DI 10.1002/em.2850190307
PG 8
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA HQ093
UT WOS:A1992HQ09300006
PM 1572346
ER

PT J
AU DILLON, D
   COMBES, R
   MCCONVILLE, M
   ZEIGER, E
AF DILLON, D
   COMBES, R
   MCCONVILLE, M
   ZEIGER, E
TI OZONE IS MUTAGENIC IN SALMONELLA
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE SALMONELLA; AMES TEST; MUTAGENICITY; TOXICITY; DOSIMETRY
ID TESTER STRAIN TA102; ESCHERICHIA-COLI-B; NITROGEN-DIOXIDE; RAT LUNGS;
   DNA; MUTATION; REPAIR; TYPHIMURIUM; INHALATION; METABOLISM
AB Ozone is a highly reactive gas that has been tested for genotoxicity in a number of systems. Induced genetic damage resulting from ozone treatment may not be readily observed because of the high toxicity of the chemical and difficulties in generating and administering controlled concentrations. The mutagenicity of ozone was investigated in Salmonella typhimurium using a plate test protocol designed for reactive vapours and gases. Ozone, at two to three consecutive doses, induced weak, albeit statistically significant, mutagenic responses in tester strain TA102 with and without Aroclor-induced rat liver S9 (lowest effective mean concentration of 0.019 ppm; 35 min total exposure). However, dose-related responses were not always obtained. No mutagenicity was detected in strains TA98, TA100, or TA1535, with or without S9. In strain TA104, ozone induced a weak response only at a single dose with S9; this response was not reproducible. Mutagenicity was dependent on the ozone flow rate and total exposure time, with variations in the optimum dose-time regimen leading to toxicity or complete inactivity. The data show that ozone is a very weak bacterial mutagen and only when tested under narrowly prescribed, subtoxic dosing conditions.
C1 NIEHS,RES TRIANGLE PK,NC 27709.
   INVERESK RES INT LTD,TRANENT,SCOTLAND.
FU NIEHS NIH HHS [N01-ES-55127]
NR 52
TC 15
Z9 16
U1 0
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PY 1992
VL 19
IS 4
BP 331
EP 337
PG 7
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA HY223
UT WOS:A1992HY22300011
PM 1600961
ER

PT J
AU WEINBERG, CR
   HERTZPICCIOTTO, I
   BAIRD, DD
   WILCOX, AJ
AF WEINBERG, CR
   HERTZPICCIOTTO, I
   BAIRD, DD
   WILCOX, AJ
TI EFFICIENCY AND BIAS IN STUDIES OF EARLY-PREGNANCY LOSS
SO EPIDEMIOLOGY
LA English
DT Article
DE SPONTANEOUS ABORTION; HUMAN CHORIONIC GONADOTROPIN; MISCLASSIFICATION;
   FERTILITY; FECUNDABILITY; SENSITIVITY; SPECIFICITY; BIAS; DATA
   COLLECTION
AB Recent advances in laboratory techniques for measuring the pregnancy hormone human chorionic gonadotropin have allowed detection of occult very early pregnancy losses based on assaying urine. We used data from the Early Pregnancy Study carried out in North Carolina to develop a simplified collection protocol for reducing costs and improving compliance in similar studies conducted in less-selected populations of women. Collection of specimens only during menses would have caused some decrease in sensitivity but would nevertheless have allowed detection of at least 75% of the losses detected in the North Carolina study. Reduced-collection protocols would also result in some loss in specificity. Simulations suggest that moderate losses in sensitivity and specificity, as would result from reduced-collection protocols, produce only moderate loss of power for detecting associations between risk factors and early pregnancy loss. A "fertility bias" exists, however, which can produce seriously misleading results when specificity is less than perfect. We therefore recommend use of a baseline group of sterile women, so that criteria for "pregnancy" can achieve specificity close to 1.0.
RP WEINBERG, CR (reprint author), NIEHS,EPIDEMIOL BRANCH,POB 12233,RES TRIANGLE PK,NC 27709, USA.
OI Wilcox, Allen/0000-0002-3376-1311; Baird, Donna/0000-0002-5544-2653
NR 0
TC 21
Z9 22
U1 0
U2 4
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 1992
VL 3
IS 1
BP 17
EP 22
DI 10.1097/00001648-199201000-00005
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA HB439
UT WOS:A1992HB43900005
PM 1554805
ER

PT J
AU THEODORE, WH
AF THEODORE, WH
TI CONSENSUS PROCEEDINGS - INTRODUCTION
SO EPILEPSY RESEARCH
LA English
DT Editorial Material
RP THEODORE, WH (reprint author), NINCDS,CLIN EPILEPSY SECT,NIH BLDG 10,ROOM 5C 205,BETHESDA,MD 20892, USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-1211
J9 EPILEPSY RES
JI Epilepsy Res.
PY 1992
SU 5
BP 1
EP 2
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA JY997
UT WOS:A1992JY99700001
ER

PT J
AU HONG, JS
AF HONG, JS
TI HIPPOCAMPAL OPIOID-PEPTIDES AND SEIZURES
SO EPILEPSY RESEARCH
LA English
DT Article
DE ENKEPHALIN; DYNORPHIN; KINDLING; ELECTROCONVULSIVE SHOCK; MOSSY FIBER;
   DENTATE GYRUS
ID WET DOG SHAKES; ENKEPHALIN-LIKE IMMUNOREACTIVITY; REPEATED
   ELECTROCONVULSIVE SHOCKS; PRODYNORPHIN MESSENGER-RNA; RAT-BRAIN; GRANULE
   CELLS; DIFFERENTIALLY ALTERS; MOTOR SEIZURES; DENTATE GYRUS; DYNORPHIN
AB We have employed a molecular biological approach to study the dynamic status of hippocampal opioid peptides in response to seizures elicited by different experimental models, such as electroconvulsive shocks (ECS) and amygdaloid kindling. Both ECS- and kindling-induced seizures triggered an initial large release of enkephalin and dynorphin, but produced opposite longterm effects on the biosynthesis of these two peptides, an increase of enkephalin, and a drastic decrease of dynorphin. Electrical stimulation of the perforant pathway produced differential changes of enkephalin and dynorphin, which were identical to those of ECS and kindling. This finding confirmed our hypothesis that the perforant pathway was responsible for the mediation of ECS- and kindling-induced changes in opioid peptide turnover. Strongest evidence indicating a role for opioid peptides in mediating the expression of seizure-related behaviors was found using the kainic acid model, where we saw that hippocampal enkephalin was essential to the expression of kainic acid-induced wet dog shakes (a preconvulsive shaking behavior). Furthermore, it was found that the granular-mossy fiber pathway of the ventral, but not the dorsal, hippocampus was essential for the expression of this shaking behavior. However, destruction of the granular-mossy fiber pathway potentiated the seizures and hippocampal cell loss induced by kainic acid. This unexpected, yet extremely interesting, finding not only distinguished the roles of the granular-mossy fiber pathway in mediating wet dog shakes vs. convulsive seizures, but also challenged the dogma that this granular-mossy fiber pathway is essential for the expression of limbic seizures.
RP HONG, JS (reprint author), NIEHS,NEUROPHARMACOL SECT,MOLEC & INTEGRAT NEUROSCI,POB 12233,RES TRIANGLE PK,NC 27709, USA.
NR 42
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-1211
J9 EPILEPSY RES
JI Epilepsy Res.
PY 1992
SU 7
BP 187
EP 195
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA KC680
UT WOS:A1992KC68000013
ER

PT J
AU LO, R
   LOCATIS, C
   ULLMER, E
   CARR, V
   BANVARD, R
   LE, Q
   WILLIAMSON, M
   ACKERMAN, M
AF LO, R
   LOCATIS, C
   ULLMER, E
   CARR, V
   BANVARD, R
   LE, Q
   WILLIAMSON, M
   ACKERMAN, M
TI DEVELOPING A DATABASE OF AUTHORING SYSTEM SOFTWARE
SO ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
LA English
DT Article
AB AuthorBase, a working prototype database of authoring system software, was developed as part of a study of authoring software conducted by the National Library of Medicine. In this article, the authors discuss development issues ranging from the scope of the database to what information to document. The prototype demonstrates that records of reasonable integrity can be derived from vendor-supplied information. However, users should understand that the database is only a starting point in searching for authoring software and a resource for becoming generally familiar with the technology.
RP LO, R (reprint author), NIH,NATL LIB MED,BETHESDA,MD 20892, USA.
NR 14
TC 1
Z9 1
U1 0
U2 0
PU ASSOC EDUC COMMUNICATIONS & TECHNOLOGY
PI WASHINGTON
PA 1025 VERMONT AVE NW, SUITE 820, WASHINGTON, DC 20005
SN 1042-1629
J9 ETR&D-EDUC TECH RES
JI ETR&D-Educ. Tech. Res. Dev.
PY 1992
VL 40
IS 2
BP 69
EP 76
DI 10.1007/BF02297051
PG 8
WC Education & Educational Research
SC Education & Educational Research
GA KH924
UT WOS:A1992KH92400007
ER

PT J
AU LOCATIS, C
   ULLMER, E
   CARR, V
   BANVARD, R
   LE, Q
   LO, R
   WILLIAMSON, M
AF LOCATIS, C
   ULLMER, E
   CARR, V
   BANVARD, R
   LE, Q
   LO, R
   WILLIAMSON, M
TI AUTHORING SYSTEMS REASSESSED
SO ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
LA English
DT Article
ID PERFORMANCE
AB A study of authoring system technology was done to update a previous study done in 1985. While the earlier study focused on software selection methods, the current one emphasizes trends in authoring tool characteristics, vendor approaches to the marketplace, and evaluation methods. It also raises questions about some of the often tacit assumptions underlying the technology's development and use.
RP LOCATIS, C (reprint author), NIH,NATL LIB MED,BETHESDA,MD 20892, USA.
NR 30
TC 3
Z9 3
U1 0
U2 0
PU ASSOC EDUC COMMUNICATIONS & TECHNOLOGY
PI WASHINGTON
PA 1025 VERMONT AVE NW, SUITE 820, WASHINGTON, DC 20005
SN 1042-1629
J9 ETR&D-EDUC TECH RES
JI ETR&D-Educ. Tech. Res. Dev.
PY 1992
VL 40
IS 2
BP 77
EP 82
DI 10.1007/BF02297052
PG 6
WC Education & Educational Research
SC Education & Educational Research
GA KH924
UT WOS:A1992KH92400008
ER

PT J
AU LOCATIS, C
   PARK, OC
AF LOCATIS, C
   PARK, OC
TI SOME UNEASY INQUIRIES INTO ID EXPERT SYSTEMS
SO ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
LA English
DT Article
ID AUTHORING SYSTEMS; DESIGN
AB Alternative approaches to developing software automating instructional development are described in this article. Information management and expert system approaches are compared. General assumptions underlying the development of all authoring tools, including conventional authoring systems, and additional assumptions underlying the development of expert ID tools are identified. Questions are raised concerning the viability of ID automation tools. It is argued that conventional authoring systems may not be as inadequate or inferior as ID expert system developers have claimed, and that of two approaches to ID automation, tools emphasizing information management are probably most useful. Information management tools, however, still may be inappropriate in some contexts.
C1 USA,RES INST,TRAINING RES LAB,ALEXANDRIA,VA.
RP LOCATIS, C (reprint author), NATL LIB MED,CTR BIOMED COMMUN,BETHESDA,MD 20209, USA.
NR 48
TC 2
Z9 2
U1 0
U2 0
PU ASSOC EDUC COMMUNICATIONS & TECHNOLOGY
PI WASHINGTON
PA 1025 VERMONT AVE NW, SUITE 820, WASHINGTON, DC 20005
SN 1042-1629
J9 ETR&D-EDUC TECH RES
JI ETR&D-Educ. Tech. Res. Dev.
PY 1992
VL 40
IS 3
BP 87
EP 94
DI 10.1007/BF02296845
PG 8
WC Education & Educational Research
SC Education & Educational Research
GA KU347
UT WOS:A1992KU34700007
ER

PT J
AU BARTORELLI, AL
   NEVILLE, RF
   KEREN, G
   POTKIN, BN
   ALMAGOR, Y
   BONNER, RF
   GESSERT, JM
   LEON, MB
AF BARTORELLI, AL
   NEVILLE, RF
   KEREN, G
   POTKIN, BN
   ALMAGOR, Y
   BONNER, RF
   GESSERT, JM
   LEON, MB
TI INVITRO AND INVIVO INTRAVASCULAR ULTRASOUND IMAGING
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE ULTRASOUND; INTRAVASCULAR IMAGING
ID CORONARY-ARTERY DISEASE; POSTMORTEM FINDINGS; HIGH-RESOLUTION;
   ATTENUATION; COLLAGEN
C1 NHLBI,CARDIOL BRANCH,BETHESDA,MD 20892.
RI Bonner, Robert/C-6783-2015
NR 12
TC 15
Z9 15
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD JAN
PY 1992
VL 13
IS 1
BP 102
EP 108
PG 7
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA HA544
UT WOS:A1992HA54400018
PM 1577016
ER

PT J
AU MASTERS, JRW
   JENKINS, WEA
   SHOEMAKER, RH
AF MASTERS, JRW
   JENKINS, WEA
   SHOEMAKER, RH
TI SCREENING OF NEW ANTICANCER AGENTS INVITRO USING PANELS OF HUMAN
   CELL-LINES DERIVED FROM NONSEMINOMATOUS GERM-CELL TUMORS AND
   TRANSITIONAL CELL CARCINOMAS OF THE BLADDER
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Article
ID COLONY-FORMING ASSAY; DIFFERENTIAL SENSITIVITIES;
   CHEMOTHERAPEUTIC-AGENTS; URINARY-BLADDER; CANCER; HEPATOCYTE; MODEL
AB Metastatic testis tumours are cured in over 80% of patients using combination chemotherapy, and this hypersensitivity is retained by the cells in vitro. To determine whether differential toxicity to testis tumour cells is useful in the screening of novel anticancer agents, we compared the toxicities of 12 compounds against panels of human bladder and testis tumour cell lines using a clonogenic assay. The compounds had screened negative against P388 in vivo, and had been retested using the human tumour colony forming assay (HTCFA) and in selected cases against human tumour xenografts. NSC 339004, chloroquinoxaline sulphonamide, was 7-fold more toxic to testis tumour than bladder cancer cells, comparing the mean of the concentrations reducing colony-forming ability by 70%. This was the only one of the compounds selected by the HTCFA shown to have clinical activity. Compound R was selectively toxic to the bladder cancer cells, and might be of value as an intravesical agent. These data indicate that panels of testis and bladder cancer cell lines might be a useful addition to the disease-oriented screening programme.
C1 NCI, DIV CANC TREATMENT, DEV THERAPEUT PROGRAM, BETHESDA, MD 20892 USA.
RP MASTERS, JRW (reprint author), UCL, INST UROL & NEPHROL, 3RD FLOOR RES LABS, 67 RIDING HOUSE ST, LONDON W1P 7PN, ENGLAND.
RI Masters, John/C-5694-2011
NR 29
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-8049
J9 EUR J CANCER
JI Eur. J. Cancer
PY 1992
VL 28A
IS 10
BP 1617
EP 1622
DI 10.1016/0959-8049(92)90054-6
PG 6
WC Oncology
SC Oncology
GA JG580
UT WOS:A1992JG58000009
PM 1389475
ER

PT J
AU ALBANES, D
   VIRTAMO, J
   RAUTALAHTI, M
   HAUKKA, J
   PALMGREN, J
   GREF, CG
   HEINONEN, OP
AF ALBANES, D
   VIRTAMO, J
   RAUTALAHTI, M
   HAUKKA, J
   PALMGREN, J
   GREF, CG
   HEINONEN, OP
TI SERUM BETA-CAROTENE BEFORE AND AFTER BETA-CAROTENE SUPPLEMENTATION
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID FOOD FREQUENCY QUESTIONNAIRE; ALPHA-TOCOPHEROL LEVELS; ERYTHROPOIETIC
   PROTOPORPHYRIA; ALCOHOL-CONSUMPTION; PLASMA-LEVELS; VITAMIN-A;
   DETERMINANTS; RETINOL; TRIAL
AB A two-month double-blind, placebo-controlled supplementation study of oral beta-carotene (20 mg daily) was conducted. Two hundred and twenty two 30-69 year old men were randomized into either a beta-carotene or placebo group, and serum samples were obtained at baseline, follow-up (2 months), and up to 12 weeks post-supplementation. Serum beta-carotene increased on average 10-fold in the beta-carotene group, from 0.53 +/- 0.32-mu-mol/l (mean +/- SD) at baseline to 4.99 +/- 2.47-mu-mol/l at follow-up (P < 0.0001), and beta-carotene levels remained elevated up to 12 weeks post-supplementation (0.61 +/- 0.15-mu-mol/l). No changes in serum retinol, alpha-tocopherol, or total cholesterol were observed. At baseline, serum beta-carotene levels were positively correlated with dietary beta-carotene (r = 0.29) and inversely correlated with body mass index and serum gamma-glutamyltransferase (r = -0.33 and r = -0.40, respectively). The inverse association with body mass index and serum gamma-glutamyltransferase persisted during active supplementation, whereas the positive association with dietary beta-carotene disappeared. In multivariate analysis, serum cholesterol was also positively associated with serum beta-carotene levels both before and after supplementation. Baseline serum beta-carotene was the factor most strongly associated (positively) with serum beta-carotene after supplementation. Our study highlights the importance of several factors which affect serum beta-carotene.
C1 SETTI,NATL PUBL HLTH INST,SF-00140 HELSINKI,FINLAND.
RP ALBANES, D (reprint author), NCI,DIV CANC PREVENT & CONTROL,EPN 211,BETHESDA,MD 20892, USA.
RI Albanes, Demetrius/B-9749-2015; Haukka, Jari/G-1484-2014; 
OI Haukka, Jari/0000-0003-1450-6208; Palmgren, Juni/0000-0002-9031-8615
FU NCI NIH HHS [N01-CN-45165]
NR 24
TC 46
Z9 46
U1 0
U2 0
PU STOCKTON PRESS
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JAN
PY 1992
VL 46
IS 1
BP 15
EP 24
PG 10
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA HJ511
UT WOS:A1992HJ51100003
PM 1348473
ER

PT J
AU CASASCO, A
   CASASCO, M
   REGUZZONI, M
   CALLIGARO, A
   STETLERSTEVENSON, WG
AF CASASCO, A
   CASASCO, M
   REGUZZONI, M
   CALLIGARO, A
   STETLERSTEVENSON, WG
TI MATRIX METALLOPROTEINASE-2 (TYPE-IV COLLAGENASE) HAS A WIDESPREAD
   DISTRIBUTION IN HUMAN EMBRYO TISSUES
SO EUROPEAN JOURNAL OF HISTOCHEMISTRY
LA English
DT Article; Proceedings Paper
CT 13TH NATIONAL MEETING OF THE ITALIAN SOC FOR THE STUDY OF THE CONNECTIVE
   TISSUE
CY SEP 18-19, 1992
CL BOLOGNA, ITALY
SP ITALIAN SOC STUDY CONNECT TISSUE
C1 NCI,BETHESDA,MD 20892.
RP CASASCO, A (reprint author), UNIV PAVIA,INST HISTOL & EMBRYOL,I-27100 PAVIA,ITALY.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 3
TC 0
Z9 0
U1 0
U2 0
PU LUIGI PONZIO E FIGLIO
PI PAVIA
PA VIA D DA CATALOGNA 1/3, 27100 PAVIA, ITALY
SN 1121-760X
J9 EUR J HISTOCHEM
JI Eur. J. Histochem.
PY 1992
VL 36
SU S
BP 24
EP 25
PG 2
WC Cell Biology
SC Cell Biology
GA KB729
UT WOS:A1992KB72900010
ER

PT J
AU GARBISA, S
   ONISTO, M
   CAENAZZO, C
   MASIERO, L
   FREDA, MP
   STETLERSTEVENSON, WG
   SCAGLIOTTI, G
AF GARBISA, S
   ONISTO, M
   CAENAZZO, C
   MASIERO, L
   FREDA, MP
   STETLERSTEVENSON, WG
   SCAGLIOTTI, G
TI ELISA AND PCR FOR MMPS AND TIMPS NEW PROGNOSTIC APPROACHES TO INVASIVE
   CANCERS
SO EUROPEAN JOURNAL OF HISTOCHEMISTRY
LA English
DT Article; Proceedings Paper
CT 13TH NATIONAL MEETING OF THE ITALIAN SOC FOR THE STUDY OF THE CONNECTIVE
   TISSUE
CY SEP 18-19, 1992
CL BOLOGNA, ITALY
SP ITALIAN SOC STUDY CONNECT TISSUE
C1 UNIV TURIN,DEPT CLIN & BIOL SCI,I-10124 TURIN,ITALY.
   NCI,PATHOL LAB,BETHESDA,MD 20892.
RP GARBISA, S (reprint author), UNIV PADUA,INST HISTOL & GEN EMBRYOL,PADUA,ITALY.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LUIGI PONZIO E FIGLIO
PI PAVIA
PA VIA D DA CATALOGNA 1/3, 27100 PAVIA, ITALY
SN 1121-760X
J9 EUR J HISTOCHEM
JI Eur. J. Histochem.
PY 1992
VL 36
SU S
BP 28
EP 29
PG 2
WC Cell Biology
SC Cell Biology
GA KB729
UT WOS:A1992KB72900012
ER

PT J
AU PARADA, LF
AF PARADA, LF
TI TRK-FAMILY TYROSINE KINASES - RECEPTORS FOR NGF-RELATED NEUROTROPHINS
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MOLEC EMBRYOL SECT,FREDERICK,MD 21702.
RI Parada, luis/B-9400-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 15
EP 15
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200044
ER

PT J
AU MIHALY, A
   KUHNT, U
   RAPP, UR
AF MIHALY, A
   KUHNT, U
   RAPP, UR
TI EXPRESSION OF RAF-PROTOONCOGENES IN THE HIPPOCAMPUS AND HIPPOCAMPAL
   SLICES OF THE GUINEA-PIG
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 ALBERT SZENT GYORGYI MED UNIV,DEPT ANAT,SZEGED,HUNGARY.
   MAX PLANCK INST BIOPHYS CHEM,DEPT NEUROBIOL,W-3400 GOTTINGEN,GERMANY.
   NCI,FCRDC,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701.
RI Mihaly, Andras/K-5096-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 68
EP 68
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200250
ER

PT J
AU KIMMIG, H
   MILES, FA
   SCHWARZ, U
AF KIMMIG, H
   MILES, FA
   SCHWARZ, U
TI EFFECT OF STATIONARY TEXTURED BACKGROUNDS ON THE INITIATION OF SMOOTH
   PURSUIT EYE-MOVEMENTS IN MONKEY
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 UNIV FREIBURG,W-7800 FREIBURG,GERMANY.
   NIH,SENSORIMOTOR RES LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 84
EP 84
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200307
ER

PT J
AU CARUNCHO, HJ
   PUIA, G
   SLOBODYANSKY, E
   DASILVA, PP
   COSTA, E
AF CARUNCHO, HJ
   PUIA, G
   SLOBODYANSKY, E
   DASILVA, PP
   COSTA, E
TI LABEL-FRACTURE STUDY OF THE EXPRESSION OF NATIVE AND RECOMBINANT
   GABA(A)-RECEPTORS
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,MATH BIOL LAB,MEMBRANE BIOL SECT,BETHESDA,MD 20892.
   FIDIA GEORGETOWN INST NEUROSCI,WASHINGTON,DC.
RI Puja, Giulia/C-3540-2015
OI Puja, Giulia/0000-0001-8385-6020
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 129
EP 129
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200480
ER

PT J
AU BOUSSAOUD, D
   BARTH, T
   WISE, SP
AF BOUSSAOUD, D
   BARTH, T
   WISE, SP
TI EYE POSITION EFFECTS ON VISUAL RESPONSES OF FRONTAL-CORTEX NEURONS
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 NIMH,NEUROPHYSIOL LAB,POOLESVILLE,MD 20837.
RI Boussaoud, Driss/B-6932-2008
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 175
EP 175
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200657
ER

PT J
AU MULLER, F
   STELMACH, GE
   TEASDALE, N
   ZEFFIRO, T
AF MULLER, F
   STELMACH, GE
   TEASDALE, N
   ZEFFIRO, T
TI DOPAMINERGIC MEDICATION IMPROVES POSTURAL SWAY MEASURES IN
   PARKINSONS-DISEASE
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Meeting Abstract
C1 UNIV WISCONSIN,MOTOR BEHAV LAB,MADISON,WI 53706.
   UNIV HOSP TUBINGEN,DEPT NEUROL,TUBINGEN,GERMANY.
   UNIV LAVAL,PERFORMANCE MOTRICE HUMAINE LAB,QUEBEC CITY G1K 7P4,QUEBEC,CANADA.
   NIH,HUMAN MOTOR CONTROL SECT,BETHESDA,MD 20892.
RI Teasdale, Normand/A-5190-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PY 1992
SU 5
BP 220
EP 220
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA KC682
UT WOS:A1992KC68200832
ER

PT J
AU HURD, S
   GOLDSTEIN, RA
   MCFADDEN, ER
   BOUSHEY, HA
   EDELL, ES
   ESCHENBACHER, WL
   GODARD, PP
   HOLGATE, ST
   HUNNINGHAKE, GW
   LAITINEN, A
   LICHTENSTEIN, LM
   PROGRAIS, L
   RANKIN, JA
   RAM, JS
   REED, CE
   REYNOLDS, HY
   WOOD, RE
AF HURD, S
   GOLDSTEIN, RA
   MCFADDEN, ER
   BOUSHEY, HA
   EDELL, ES
   ESCHENBACHER, WL
   GODARD, PP
   HOLGATE, ST
   HUNNINGHAKE, GW
   LAITINEN, A
   LICHTENSTEIN, LM
   PROGRAIS, L
   RANKIN, JA
   RAM, JS
   REED, CE
   REYNOLDS, HY
   WOOD, RE
TI INVESTIGATIVE USE OF BRONCHOSCOPY, LAVAGE AND BRONCHIAL BIOPSIES IN
   ASTHMA AND OTHER AIRWAYS DISEASES - WORKSHOP HELD IN COLUMBIA, MARYLAND
   ON NOVEMBER 19-20, 1990
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Editorial Material
ID BRONCHOALVEOLAR LAVAGE; MAST-CELLS; MILD ASTHMA; ALLERGEN CHALLENGE;
   ANTIGEN CHALLENGE; MEDIATOR RELEASE; INFLAMMATION; EXERCISE;
   BRONCHOCONSTRICTION; PROSTAGLANDIN-D2
C1 NIAID,DAIT,BETHESDA,MD 20892.
RP HURD, S (reprint author), NHLBI,DLD,WESTWOOD BLDG,ROOM 6A-15,BETHESDA,MD 20892, USA.
NR 40
TC 22
Z9 22
U1 0
U2 0
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0903-1936
J9 EUR RESPIR J
JI Eur. Resp. J.
PD JAN
PY 1992
VL 5
IS 1
BP 115
EP 121
PG 7
WC Respiratory System
SC Respiratory System
GA HC209
UT WOS:A1992HC20900019
ER

PT J
AU RAMIREZ, M
   SANCHEZ, B
   ARECHAGA, G
   GARCIA, S
   LARDELLI, P
   VENZON, D
   DEGANDARIAS, JM
AF RAMIREZ, M
   SANCHEZ, B
   ARECHAGA, G
   GARCIA, S
   LARDELLI, P
   VENZON, D
   DEGANDARIAS, JM
TI BILATERAL DISTRIBUTION OF AMINOPEPTIDASE ACTIVITIES IN SELECTED
   STRUCTURES OF A PHOTONEUROENDOCRINE CIRCUIT AND OTHER RAT-BRAIN AREAS
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY
LA English
DT Article
DE AMINOPEPTIDASE; ARYLAMIDASE ACTIVITY; ASYMMETRY; RAT BRAIN
ID THYROTROPIN-RELEASING-HORMONE; II BINDING-SITES; ANGIOTENSIN-II;
   ANTERIOR-PITUITARY; SYSTEM; MELATONIN; GANGLIA; NUCLEUS; RETINA
AB Provided that soluble aminopeptidases, the most abundant proteolytic enzymes found in brain, are involved in the metabolism of several neuropeptides, their activity could be a reflect of neuropeptide function. Therefore, in order to analyze their rate of participation, we have measured 4 soluble aminopeptidase activities: leucine aminopeptidase, arginine aminopeptidase, aspartate aminopeptidase, and pyroglutamate aminopeptidase, using arylamide derivatives as substrates, in selected structures integrating the photoneuroendocrine circuit related to the melatonin rhythm generating system and other rat brain areas. The regional distribution of all the activities was heterogeneous: a 3-fold (leucine-. arginine- and aspartate-aminopeptidase) and 5-fold (pyroglutamate aminopeptidase) difference was observed between the regions with the highest and lowest activity. Significant differences were displayed between the left and right retina for pyroglutamate aminopeptidase and arginine aminopeptidase activities. High levels of pyroglutamate aminopeptidase were evident in the retina and adenohypophysis, which is consistent with a role for thyrotropin releasing hormone in photoreceptive mechanisms, and support its well established role in controlling thyrotropin releasing hormone in anterior pituitary. The presence of a high activity rate of aspartate aminopeptidase in adenohypophysis implies an active participation of angiotensin peptides at this level.
C1 NIH,BIOSTATIST & DATA MANAGEMENT SECT,BETHESDA,MD 20892.
RP RAMIREZ, M (reprint author), UNIV BASQUE COUNTRY,SCH MED,DEPT PHYSIOL,POB 699,BILBAO,SPAIN.
RI Venzon, David/B-3078-2008
NR 32
TC 1
Z9 1
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG
PI HEIDELBERG
PA IM WEIHER 10, D-69121 HEIDELBERG, GERMANY
SN 0232-7384
J9 EXP CLIN ENDOCRINOL
JI Exp. Clin. Endocrinol.
PY 1992
VL 99
IS 2
BP 59
EP 63
PG 5
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA JA966
UT WOS:A1992JA96600001
PM 1353453
ER

PT J
AU CARPENTIER, JL
   GORDEN, P
   LEW, DP
AF CARPENTIER, JL
   GORDEN, P
   LEW, DP
TI CALCIUM-IONS ARE REQUIRED FOR THE INTRACELLULAR ROUTING OF INSULIN AND
   ITS RECEPTOR
SO EXPERIMENTAL CELL RESEARCH
LA English
DT Article
ID ENDOPLASMIC-RETICULUM; HUMAN-NEUTROPHILS; RAT HEPATOCYTES; FUSION;
   INTERNALIZATION; CELLS; AUTORADIOGRAPHY; ENDOCYTOSIS; INVOLVEMENT;
   EXOCYTOSIS
C1 NIDDKD,DIABETES BRANCH,BETHESDA,MD.
   GENEVA UNIV HOSP,DEPT MED,DIV INFECT DIS,GENEVA,SWITZERLAND.
RP CARPENTIER, JL (reprint author), UNIV GENEVA,INST HISTOL & EMBRYOL,DEPT MORPHOL,CH-1211 GENEVA 4,SWITZERLAND.
NR 33
TC 19
Z9 19
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0014-4827
J9 EXP CELL RES
JI Exp. Cell Res.
PD JAN
PY 1992
VL 198
IS 1
BP 144
EP 149
DI 10.1016/0014-4827(92)90160-A
PG 6
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA GU986
UT WOS:A1992GU98600020
PM 1727048
ER

PT J
AU XU, GT
   ZIGLER, JS
   LOU, MF
AF XU, GT
   ZIGLER, JS
   LOU, MF
TI THE POSSIBLE MECHANISM OF NAPHTHALENE CATARACT IN RAT AND ITS PREVENTION
   BY AN ALDOSE REDUCTASE INHIBITOR (AL01576)
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE CATARACT; NAPHTHALENE; DIHYDROXYNAPHTHALENE; NAPHTHALENE DIHYDRODIOL;
   NAPHTHOQUINONE; ALDOSE REDUCTASE INHIBITOR; PIGMENTATION; GLUTATHIONE;
   PROTEIN THIOL MIXED DISULFIDE; DISULFIDE CROSS-LINKING; ACTIVE TRANSPORT
ID MIXED DISULFIDES; LENS; PROTEINS; REDOX
C1 ALCON LABS INC,CATARACT RES,FT WORTH,TX 76115.
   NEI,BETHESDA,MD 20892.
NR 26
TC 43
Z9 44
U1 0
U2 1
PU ACADEMIC PRESS LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0014-4835
J9 EXP EYE RES
JI Exp. Eye Res.
PD JAN
PY 1992
VL 54
IS 1
BP 63
EP 72
DI 10.1016/0014-4835(92)90070-9
PG 10
WC Ophthalmology
SC Ophthalmology
GA HD241
UT WOS:A1992HD24100009
PM 1541342
ER

PT J
AU XU, GT
   ZIGLER, JS
   LOU, MF
AF XU, GT
   ZIGLER, JS
   LOU, MF
TI ESTABLISHMENT OF A NAPHTHALENE CATARACT MODEL INVITRO
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE CATARACT; NAPHTHALENE; NAPHTHALENE DIHYDRODIOL; 1-NAPHTHOL; 2-NAPHTHOL;
   1,2-DIHYDROXYNAPHTHALENE; 1,2-NAPHTHOQUINONE; ALDOSE REDUCTASE
   INHIBITOR; GLUTATHIONE; PROTEIN THIOL MIXED DISULFIDE; ACTIVE TRANSPORT;
   DISULFIDE CROSS-LINKING
ID REDOX; RAT
C1 ALCON LABS INC,CATARACT RES,FT WORTH,TX 76115.
   NEI,BETHESDA,MD 20892.
NR 16
TC 36
Z9 36
U1 0
U2 0
PU ACADEMIC PRESS LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0014-4835
J9 EXP EYE RES
JI Exp. Eye Res.
PD JAN
PY 1992
VL 54
IS 1
BP 73
EP 81
DI 10.1016/0014-4835(92)90071-Y
PG 9
WC Ophthalmology
SC Ophthalmology
GA HD241
UT WOS:A1992HD24100010
PM 1541343
ER

PT J
AU RUSSELL, P
   ZIGLER, JS
AF RUSSELL, P
   ZIGLER, JS
TI ANALYSIS OF THE EFFECT OF EYE BANK STORAGE-CONDITIONS ON PRIMATE LENS
   EPITHELIUM
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Letter
ID AGE-RELATED-CHANGES
RP RUSSELL, P (reprint author), NEI,BLDG 6,ROOM 228,BETHESDA,MD 20892, USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0014-4835
J9 EXP EYE RES
JI Exp. Eye Res.
PD JAN
PY 1992
VL 54
IS 1
BP 153
EP 155
DI 10.1016/0014-4835(92)90081-3
PG 3
WC Ophthalmology
SC Ophthalmology
GA HD241
UT WOS:A1992HD24100020
PM 1541335
ER

PT J
AU MIYAMOTO, A
   MAKI, T
   BLACKMAN, MR
   ROTH, GS
AF MIYAMOTO, A
   MAKI, T
   BLACKMAN, MR
   ROTH, GS
TI AGE-RELATED-CHANGES IN THE MECHANISMS OF LHRH-STIMULATED LH-RELEASE FROM
   PITUITARY-CELLS INVITRO
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE PITUITARY CELLS; LH RELEASE; AGING
ID PROTEIN KINASE-C; CALCIUM MOBILIZATION; HORMONE RECEPTORS; RAT;
   ACTIVATION; RESPONSES; CHANNELS; GNRH
AB In vitro release of LH in response to LHRH, phorbol myristate acetate (PMA), the ionophore A23187, and nifedipine was evaluated in primary cultures of anterior pituitary cells from intact mature (6 to 7 month) and old (23 to 24 month) male Wistar rats.  LH release from pituitary cells is reduced approximately 30% and 60% after 4 and 48 h of 10(-7)M LHRH stimulation in cells of old rats, respectively.  This impairment may be secondary to a loss of LHRH receptors.  LHRH-stimulated LH release from cells of mature rats was inhibited 70% by the voltage-gated calcium channel blocker, nifedipine (10(-6)M), whereas LHRH-stimulated LH release from cells of old rats was too low to detect the effects of this drug.  Age changes can be partially reversed by A23187 and PMA during 4 h, but not 48 hrs of stimulation.  It therefore appears that short- and long-term (4 h and 48 h, respectively) stimulation of LH release may proceed through separate mechanisms that are differentially affected by aging.
C1 FRANCIS SCOTT KEY MED CTR,NIA,GERONTOL RES CTR,MOLEC PHYSIOL & GENET SECT,4940 EASTERN AVE,BALTIMORE,MD 21224.
   FRANCIS SCOTT KEY MED CTR,NIA,GERONTOL RES CTR,ENDOCRINOL SECT,BALTIMORE,MD 21224.
NR 19
TC 4
Z9 4
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0531-5565
J9 EXP GERONTOL
JI Exp. Gerontol.
PY 1992
VL 27
IS 2
BP 211
EP 219
DI 10.1016/0531-5565(92)90045-2
PG 9
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA HM214
UT WOS:A1992HM21400007
PM 1325923
ER

PT J
AU PLUZNIK, DH
   FRIDMAN, R
   REICH, R
AF PLUZNIK, DH
   FRIDMAN, R
   REICH, R
TI CORRELATION IN THE EXPRESSION OF TYPE-IV COLLAGENASE AND THE INVASIVE
   AND CHEMOTACTIC ABILITIES OF MYLOMONOCYTIC CELLS DURING DIFFERENTIATION
   INTO MACROPHAGES
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Article
DE DIFFERENTIATION; MYELOID CELLS; COLLAGENASE; INVASION; CHEMOTAXIS
ID MYELOID-LEUKEMIA CELLS; HUMAN MONONUCLEAR PHAGOCYTES; BASEMENT-MEMBRANE
   COLLAGEN; METASTATIC TUMOR-CELLS; ENZYME; METALLOPROTEINASES;
   GELATINASES; SECRETION; RECEPTORS; INHIBITOR
AB Monomyelocytic phagocytes originate in the bone marrow and while differentiating into macrophages migrate to inflammatory foci and target tissues by egress from the capillary blood vessels.  During such diapedesis, the cells must traverse tissue barriers such as basement membrane, which has type IV collagen as its principal structural element.  We studied whether the expression of type IV collagenase activity, invasion through basement membrane, and the response to inflammatory chemoattractants are related to each other and to the process of differentiation of murine M1 myeloid leukemia cells into macrophages. M1 cells stimulated with mouse lung-conditioned medium (MLCM) or interleukin 6 (IL6) differentiate into macrophages by 72 h, as determined by expression of Fc receptors, induction of lysozyme, and morphological changes from blast cells to mature macrophages.  During this process of differentiation the invasive ability of the cells and the amount of type IV collagenase in the supernatants from the invading cells continuously increased up to 72 h.  Zymographic analysis of supernatants of the invading cells revealed a single 100-kd metalloproteinase with gelatinolytic activity.  Chemotaxis towards arachidonic acid metabolites, which are present in inflamed tissues, was detected only in differentiated cells.  Studies with thioglycolate (TG)-elicited peritoneal macrophages gave results similar to those obtained with differentiated M1 cells, showing that the ability to invade basement membrane, the expression of type IV collagenase, and the chemotactic response to inflammatory chemoattractants all increased with the differentiation of myeloid cells and reached their highest expression in fully differentiated cells.
C1 NIDR,DEV BIOL & ANOMALIES LAB,BETHESDA,MD 20892.
RP PLUZNIK, DH (reprint author), US FDA,CBER,DIV CYTOKINE BIOL,HFB 800,BLDG 29A,ROOM 3B-19,8800 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 36
TC 28
Z9 28
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 57
EP 63
PG 7
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300010
PM 1315691
ER

PT J
AU GREENBERGER, J
   LEIF, J
   CRAWFORD, D
   ANKLESARIA, P
   ENGLISH, D
   SAKAKEENY, M
   RUBIN, J
   PIERCE, J
   SHADDUCK, R
   FITZGERALD, TJ
AF GREENBERGER, J
   LEIF, J
   CRAWFORD, D
   ANKLESARIA, P
   ENGLISH, D
   SAKAKEENY, M
   RUBIN, J
   PIERCE, J
   SHADDUCK, R
   FITZGERALD, TJ
TI HUMORAL AND CELL-SURFACE INTERACTIONS DURING GAMMA-IRRADIATION
   LEUKEMOGENESIS INVITRO
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Article
DE GAMMA-IRRADIATION; LEUKEMOGENESIS INVITRO; HEMATOPOIESIS; BONE MARROW
   STROMA
ID COLONY-STIMULATING FACTOR; PROTEIN KINASE-C; LOW-DOSE-RATE;
   GROWTH-FACTOR; FACTOR CSF-1; GM-CSF; IONIZING-RADIATION; MALIGNANT
   TRANSFORMATION; AUTOCRINE STIMULATION; HEMATOPOIETIC-CELLS
AB Gamma-irradiation of plateau phase cultures of the clonal murine bone marrow stromal cell line D2XRII followed by cocultivation of a clonal interleukein 3 (IL-3) (granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent hematopoietic progenitor cell line FDC-P1JL26 results in a significant increase in "cobblestone islands" of attachment and emergence of subclonal factor-independent malignant sublines.  Biochemical purification of conditioned medium from irradiated D2XRII cells yielded a 75,000-dalton glycoprotein termed leukemogenic stromal factor (LSF) that was neutralized by a polyclonal antiserum to murine macrophage colony-stimulating factor (M-CSF).  A monoclonal antibody to the murine M-CSF receptor (c-fms) neutralized the biological activity of this molecule in a manner comparable to its effect on recombinant human or murine M-CSF.  FDC-P1JL26 parent cells were positive for Ly5, MEL-14, mGR, VLA-4, PGP-1 (CD44), and Thy1.2.  After culture in LSF, Thy1.2, MEL-14, and mGR became undetectable; however, significant cell surface MAC-1 antigen and c-fms (M-CSF receptor) were expressed.  Neither line was positive for Ly6, Ly22, I-CAM-1, or B220 antigen.  LSF-precultured FDC-P1JL26 cells transferred as single cells to microwell culture with 5000-cGy-irradiated D2XRII cells revealed a 60-fold increase in frequency of cobblestone island formation and evolution of factor-independent subclones compared to the parent line.  Both parent and LSF-precultured cells became factor independent at a 100-fold lower frequency if kept in suspension in LSF in the absence of stromal cells.  Antiserum to M-CSF or monoclonal antibody to the murine M-CSF receptor (c-fms) did not inhibit or displace cobblestone island formation by either clone of FDC-P1 on irradiated stromal cells indicating a mechanism of binding not involving the M-CSF receptor.  However, antiserum to the M-CSF receptor inhibited growth of one factor-independent subclone.  In separate studies, a subclone of IL-3-dependent 32Dc13 cells, expressing the transfected murine c-fms protooncogene but not the parent 32Dc13 cell line or another subclone expressing the transfected gene for the human M-CSF receptor, showed adherence and became factor independent when cocultivated with irradiated D2XRII stromal cells.  Thus, irradiated stromal cells bind M-CSF receptor-positive hematopoietic progenitor cells and induce c-fms-dependent factor-independent tumorigenic subclones.  The cellular interactions in this model may be relevant to gamma-irradiation leukemogenesis in vivo.
C1 NCI,MOLEC & CELLULAR BIOL LAB,BETHESDA,MD 20892.
   WESTERN PENN HOSP,DEPT MED,PITTSBURGH,PA 15224.
RP GREENBERGER, J (reprint author), UNIV MASSACHUSETTS,MED CTR,DEPT RADIAT ONCOL,55 LAKE AVE N,WORCESTER,MA 01655, USA.
FU NCI NIH HHS [CA39851, CA15237]; NIDCR NIH HHS [DE08798]
NR 60
TC 20
Z9 21
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 92
EP 102
PG 11
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300016
PM 1533594
ER

PT J
AU ROTTEM, M
   BARBIERI, S
   KINET, JP
   METCALFE, DD
AF ROTTEM, M
   BARBIERI, S
   KINET, JP
   METCALFE, DD
TI KINETICS OF THE APPEARANCE OF FCERI-BEARING CELLS IN IL-3-DEPENDENT
   MOUSE BONE-MARROW CULTURES
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 112
EP 112
PG 1
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300044
ER

PT J
AU MANOHAR, V
   HUPPI, K
   HOFFMAN, T
AF MANOHAR, V
   HUPPI, K
   HOFFMAN, T
TI SPLENIC STEM-CELLS OF NEW-ZEALAND BLACK MICE - ISOLATION, AND
   PHENOTYPIC, HISTOCHEMICAL, GENOMIC AND FUNCTIONAL-CHARACTERIZATION
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
C1 CTR BIOL EVALUAT & RES,DIV HEMATOL,BETHESDA,MD.
   NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 114
EP 114
PG 1
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300050
ER

PT J
AU LEVINE, AS
   BADMAN, DG
AF LEVINE, AS
   BADMAN, DG
TI PROCEEDINGS FROM THE SYMPOSIUM ON THE STROMAL REGULATION OF
   HEMATOPOIESIS - INTRODUCTION
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Editorial Material
C1 NIDDKD,BETHESDA,MD.
RP LEVINE, AS (reprint author), NHLBI,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 121
EP 122
PG 2
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300077
ER

PT J
AU BODINE, DM
   MCDONAGH, KT
   DONAHUE, RE
   NIENHUIS, AW
AF BODINE, DM
   MCDONAGH, KT
   DONAHUE, RE
   NIENHUIS, AW
TI GENE INSERTION INTO HEMATOPOIETIC STEM-CELLS
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
ID THERAPY
C1 NIH,CLIN HEMATOL BRANCH,BETHESDA,MD 20892.
NR 9
TC 1
Z9 1
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 125
EP 126
PG 2
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300080
ER

PT J
AU DAWID, I
AF DAWID, I
TI GROWTH-FACTOR ACTION AND GENE-EXPRESSION IN XENOPUS EMBRYOGENESIS
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
ID MESODERM INDUCTION; ACTIVIN-A; EMBRYOS
C1 NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892.
   NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 126
EP 127
PG 2
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300081
ER

PT J
AU REDDI, AH
AF REDDI, AH
TI BONE MORPHOGENESIS AND HEMATOPOIESIS
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
ID OSTEOGENIN; PROTEIN
C1 NIDR,BONE CELL BIOL SECT,BETHESDA,MD 20892.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU CARDEN JENNINGS PUBL CO LTD
PI CHARLOTTESVILLE
PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903
SN 0301-472X
J9 EXP HEMATOL
JI Exp. Hematol.
PD JAN
PY 1992
VL 20
IS 1
BP 135
EP 136
PG 2
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA GX273
UT WOS:A1992GX27300092
ER

PT J
AU OVERBY, L
   NISHIO, SJ
   LAWTON, MP
   PLOPPER, CG
   PHILPOT, RM
AF OVERBY, L
   NISHIO, SJ
   LAWTON, MP
   PLOPPER, CG
   PHILPOT, RM
TI CELLULAR-LOCALIZATION OF FLAVIN-CONTAINING MONOOXYGENASE IN RABBIT LUNG
SO EXPERIMENTAL LUNG RESEARCH
LA English
DT Article
ID SPECIES-DEPENDENT EXPRESSION; CYTOCHROME-P-450 MONOOXYGENASE; CLARA
   CELLS; PRIMARY ALKYLAMINES; ENZYME COMPONENTS; II CELLS; LIVER; RAT;
   IDENTIFICATION; METABOLISM
AB A specific form of flavin monooxygenase has been identified in the lungs of a number of species.  Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen, sulfur-, and phosphorous-containing xenobiotics, some of which form highly toxic reactive intermediates.  We have identified the nonciliated bronchiolar epithelial (Clara) cell as the predominant location for this enzyme in rabbit lung.  In addition, protein in ciliated, endothelial, type I, and type II cells and in tracheal lining layer reacted with antibodies to FMOp.  In all these cell types antigen was found associated with cytoplasmic organelles, and in the Clara cell antigen was most concentrated in areas rich in smooth endoplasmic reticulum.  Staining of ciliated surfaces was also observed at both the light and electron microscopy levels.  Extracellular antigen was also apparent in tracheal lining layer smeared onto glass slides.  We compared the location of the FMOp with that of two enzymes of the cytochrome P-450 monooxygenase system (studied here and elsewhere), cytochrome P450 IIB (P450 IIB), and NADPH cytochrome P450 reductase (reductase), and concluded that (1) FMOp is detected in all cells where P450 IIB and reductase are both present (Clara, type II, and ciliated); (2) FMOp and P450 IIB, but not reductase, are detected in endothelial cells; (3) P450 IIB alone is detected in the plasma membrane, cilia, and microvillae of ciliated cells and plasma membrane of endothelial cells; and (4) FMOp alone is detected in type I cells.
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,POB 12233,RES TRIANGLE PK,NC 27709.
   UNIV CALIF DAVIS,SCH VET MED,DEPT ANAT,DAVIS,CA 95616.
NR 24
TC 21
Z9 21
U1 0
U2 0
PU HEMISPHERE PUBL CORP
PI BRISTOL
PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598
SN 0190-2148
J9 EXP LUNG RES
JI Exp. Lung Res.
PD JAN-MAR
PY 1992
VL 18
IS 1
BP 131
EP 144
DI 10.3109/01902149209020656
PG 14
WC Respiratory System
SC Respiratory System
GA GZ494
UT WOS:A1992GZ49400011
PM 1572320
ER

PT J
AU OLEARY, DDM
   SCHLAGGAR, BL
   STANFIELD, BB
AF OLEARY, DDM
   SCHLAGGAR, BL
   STANFIELD, BB
TI THE SPECIFICATION OF SENSORY CORTEX - LESSONS FROM CORTICAL
   TRANSPLANTATION
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article; Proceedings Paper
CT 1ST CONF ON BIOLOGICAL REPLACEMENT IN SENSORY SYSTEMS
CY MAR 15-17, 1991
CL ST LOUIS, MO
SP CENT INST DEAF, NIDOCD, MONSANTO, RETINITIS PIGMENTOSA INT
ID CEREBRAL-CORTEX; BARREL SUBFIELD; SOMATOSENSORY CORTEX; NEURONS; RAT;
   CONNECTIONS; PROJECTIONS; AXONS; ELIMINATION; ORGANIZATION
C1 NIMH,CTR ANIM,POOLESVILLE,MD 20837.
RP OLEARY, DDM (reprint author), SALK INST BIOL STUDIES,MOLEC NEUROBIOL LAB,LA JOLLA,CA 92037, USA.
FU NEI NIH HHS [R01 EY07025]; NINDS NIH HHS [P01 NS17763]
NR 39
TC 26
Z9 26
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD JAN
PY 1992
VL 115
IS 1
BP 121
EP 126
DI 10.1016/0014-4886(92)90234-H
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA GX804
UT WOS:A1992GX80400025
PM 1728557
ER

PT J
AU BACHRACH, CA
   STOLLEY, KS
   LONDON, KA
AF BACHRACH, CA
   STOLLEY, KS
   LONDON, KA
TI RELINQUISHMENT OF PREMARITAL BIRTHS - EVIDENCE FROM NATIONAL SURVEY DATA
SO FAMILY PLANNING PERSPECTIVES
LA English
DT Article
ID ADOLESCENT PREGNANCY; RESOLUTION; DECISIONS; ADOPTION; CHILDREN;
   MOTHERS; PLANS
AB According to 1982 and 1988 NSFG data, unmarried white women are far less likely than they were in the early 1970s to place their children for adoption.  The levels of relinquishment among black women have remained low throughout this period, and relinquishment among Hispanic women may be virtually nonexistent.  Multivariate analysis of the determinants of relinquishment among unmarried non-Hispanic white women suggests that having a well-educated mother, being in school at the time of conception, having no labor force experience, and being older are positively associated with placing a child for adoption.  Sons were found to be less likely to be relinquished than daughters.
C1 NATL CTR HLTH STAT,HYATTSVILLE,MD 20782.
   OLD DOMINION UNIV,DEPT SOCIOL & CRIMINAL JUSTICE,NORFOLK,VA 23508.
RP BACHRACH, CA (reprint author), NICHHD,CTR POPULAT RES,DEMOG & BEHAV SCI BRANCH,BETHESDA,MD 20892, USA.
NR 29
TC 54
Z9 54
U1 0
U2 3
PU ALAN GUTTMACHER INST
PI NEW YORK
PA 120 WALL STREET, NEW YORK, NY 10005
SN 0014-7354
J9 FAM PLANN PERSPECT
JI Fam. Plann. Perspect.
PD JAN-FEB
PY 1992
VL 24
IS 1
BP 27
EP &
DI 10.2307/2135722
PG 0
WC Demography; Family Studies
SC Demography; Family Studies
GA HD565
UT WOS:A1992HD56500005
PM 1294072
ER

PT J
AU ABUGO, O
   LEVY, A
   RIFKIND, JM
AF ABUGO, O
   LEVY, A
   RIFKIND, JM
TI QUATERNARY CONFORMATION OF HEMOGLOBIN PROBED BY THE HEME CONFIGURATION
   OF THE OXIDIZED SUBUNITS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A55
EP A55
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000309
ER

PT J
AU ACKERMAN, EJ
   JENKINS, TM
   LEVIN, JD
   SAXENA, JK
   WILSON, SH
AF ACKERMAN, EJ
   JENKINS, TM
   LEVIN, JD
   SAXENA, JK
   WILSON, SH
TI A ROLE FOR DNA-POLYMERASE BETA IN DNA-REPLICATION IN XENOPUS OOCYTES AND
   EXTRACTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
   NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A480
EP A480
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002755
ER

PT J
AU AIDA, K
   NEGISHI, M
AF AIDA, K
   NEGISHI, M
TI PRESENCE OF A REPRESSOR REGULATING THE SEX-SPECIFIC EXPRESSION OF MOUSE
   STEROID 15-ALPHA-HYDROXYLASE GENE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A456
EP A456
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002611
ER

PT J
AU AKESON, M
   SCHARFF, J
   LANTZ, T
   SHARP, C
   NEVILLE, DM
AF AKESON, M
   SCHARFF, J
   LANTZ, T
   SHARP, C
   NEVILLE, DM
TI EVIDENCE THAT PLASMA-MEMBRANE DEPOLARIZATION BLOCKS BASAL-LATERAL BUT
   NOT APICAL ROUTING OF ACID PROCESSED ENVELOPED VIRUSES IN MDCK CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A223
EP A223
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001280
ER

PT J
AU ALVAREZGONZALEZ, R
   MARTINEZCADENA, MG
   STANLEY, SJ
   MOSS, J
AF ALVAREZGONZALEZ, R
   MARTINEZCADENA, MG
   STANLEY, SJ
   MOSS, J
TI INHIBITION OF POLY(ADP-RIBOSE) POLYMERASE BY ARGININE SPECIFIC
   MONO(ADP-RIBOSYL)ATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV N TEXAS,TCOM,DEPT MICROBIOL & IMMUNOL,FT WORTH,TX 76107.
   NHLBI,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A282
EP A282
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001610
ER

PT J
AU ANSARI, A
   JONES, C
   HENRY, ER
   HOFRICHTER, J
   EATON, WA
AF ANSARI, A
   JONES, C
   HENRY, ER
   HOFRICHTER, J
   EATON, WA
TI DYNAMICS OF MYOGLOBIN CONFORMATIONAL-CHANGES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A54
EP A54
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000306
ER

PT J
AU ARCHER, SJ
   TORCHIA, DA
   BAX, A
   ROBERTS, AB
   SPORN, MB
   WEATHERBEE, J
   TSANG, M
   LUCAS, R
   OGAWA, Y
   PIEZ, K
AF ARCHER, SJ
   TORCHIA, DA
   BAX, A
   ROBERTS, AB
   SPORN, MB
   WEATHERBEE, J
   TSANG, M
   LUCAS, R
   OGAWA, Y
   PIEZ, K
TI STRUCTURAL STUDIES OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) USING
   MULTIDIMENSIONAL NMR-SPECTROSCOPY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
   NCI,BETHESDA,MD 20892.
   NIDDK,BETHESDA,MD 20892.
   RES & DEV SYST INC,MINNEAPOLIS,MN 55413.
   CELTRIX LABS INC,PALO ALTO,CA 94303.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A469
EP A469
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002693
ER

PT J
AU ARISPE, N
   OLIVARES, E
   JAIMOVICH, E
   ROJAS, E
AF ARISPE, N
   OLIVARES, E
   JAIMOVICH, E
   ROJAS, E
TI SCREENING OF RYANODINE (RYA) SENSITIVE CHANNELS IN
   SARCOPLASMIC-RETICULUM (SR) VESICLES FROM CRUSTACEAN SKELETAL-MUSCLE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CELL BIOL & GENET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A24
EP A24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000131
ER

PT J
AU ARMSTRONG, DL
   WHITE, RE
   LEE, AB
   SHCHERBATKO, AD
   SCHONBRUNN, A
AF ARMSTRONG, DL
   WHITE, RE
   LEE, AB
   SHCHERBATKO, AD
   SCHONBRUNN, A
TI NATRIURETIC PEPTIDES MODULATE CA2+-ACTIVATED K+ CHANNEL ACTIVITY THROUGH
   CGMP STIMULATED PROTEIN DEPHOSPHORYLATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELL MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A382
EP A382
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002193
ER

PT J
AU AURORA, R
   HERR, W
   PORTER, D
   KNUTSON, JR
   HENSLEY, P
AF AURORA, R
   HERR, W
   PORTER, D
   KNUTSON, JR
   HENSLEY, P
TI FLUORESCENCE ANALYSIS OF THE RECOGNITION OF DNA TARGET SEQUENCES BY
   OCT-1, A POU CLASS HOMEODOMAIN PROTEIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 COLD SPRING HARBOR LAB,COLD SPRING HARBOR,NY 11724.
   SUNY STONY BROOK,DEPT MOLEC MICROBIOL,STONY BROOK,NY 11794.
   NHLBI,CELL BIOL LAB,BETHESDA,MD 20892.
   SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOLEC SCI,KING OF PRUSSIA,PA 19406.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A487
EP A487
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002796
ER

PT J
AU BALASUNDARAM, D
   TABOR, CW
   TABOR, H
AF BALASUNDARAM, D
   TABOR, CW
   TABOR, H
TI SPERMIDINE IS REQUIRED FOR THE MAINTENANCE OF NORMAL MITOCHONDRIA IN A
   DELTA-SPE2 NULL MUTANT OF SACCHAROMYCES-CEREVISIAE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDKD,BIOCHEM PHARMACOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A230
EP A230
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001321
ER

PT J
AU BARNETT, VA
   SCHOENBERG, M
AF BARNETT, VA
   SCHOENBERG, M
TI TEMPERATURE-DEPENDENCE OF THE STIFFNESS OF MYOSIN.ATP CROSSBRIDGES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS,PHYS BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A294
EP A294
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001679
ER

PT J
AU BEARD, WA
   KUMAR, A
   WILSON, SH
AF BEARD, WA
   KUMAR, A
   WILSON, SH
TI TEMPLATE PRIMER INTERACTIONS WITH RECOMBINANT FORMS OF HIV-1
   REVERSE-TRANSCRIPTASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A357
EP A357
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002046
ER

PT J
AU BROYLES, RH
   STEWART, DR
   BERG, PE
   SCHECHTER, AN
AF BROYLES, RH
   STEWART, DR
   BERG, PE
   SCHECHTER, AN
TI A FERRITIN-LIKE PROTEIN IN K562 CELL NUCLEAR EXTRACTS BINDS TO AN IRON
   RESPONSIVE ELEMENT CONSENSUS SEQUENCE IN A 5' CONTROL REGION OF THE
   HUMAN BETA GLOBIN GENE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV OKLAHOMA,HLTH SCI CTR,DEPT BIOCHEM & MOLEC BIOL,OKLAHOMA CITY,OK 73190.
   NIDDKD,CHEM BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A72
EP A72
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000410
ER

PT J
AU CASASFINET, JR
   KUMAR, A
   KARPEL, RL
   WILSON, SH
AF CASASFINET, JR
   KUMAR, A
   KARPEL, RL
   WILSON, SH
TI FLUOROMETRIC CHARACTERIZATION OF HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1)
   REVERSE-TRANSCRIPTASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV MARYLAND,DEPT CHEM & BIOCHEM,CATONSVILLE,MD 21228.
   NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A486
EP A486
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002795
ER

PT J
AU CHEN, RF
   PORTER, D
   KNUTSON, JR
AF CHEN, RF
   PORTER, D
   KNUTSON, JR
TI TIME-RESOLVED FLUORESCENCE OF ALPHA-LACTALBUMIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,CELL BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A312
EP A312
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001784
ER

PT J
AU CHEN, YD
   CHALOVICH, JM
AF CHEN, YD
   CHALOVICH, JM
TI STUDY OF A MOSAIC MULTIPLE-BINDING MODEL FOR THE BINDING OF CALDESMON
   AND MYOSIN SUBFRAGMENT-1 (S-1) TO ACTIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
   E CAROLINA UNIV,SCH MED,DEPT BIOCHEM,GREENVILLE,NC 27858.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A154
EP A154
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000879
ER

PT J
AU CHERNOMORDIK, L
   VOGEL, SS
   LEIKINA, E
   ZIMMERBERG, J
AF CHERNOMORDIK, L
   VOGEL, SS
   LEIKINA, E
   ZIMMERBERG, J
TI INHIBITION OF BIOLOGICAL MEMBRANE-FUSION BY AMPHIPATHIC COMPOUNDS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,THEORET & PHYS BIOL LAB,BETHESDA,MD 20892.
RI Vogel, Steven/A-3585-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A499
EP A499
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002866
ER

PT J
AU CHOI, I
   DIAMOND, A
   JUNG, J
   LEE, B
   BURK, RF
   HATFIELD, D
AF CHOI, I
   DIAMOND, A
   JUNG, J
   LEE, B
   BURK, RF
   HATFIELD, D
TI EFFECTS OF SELENIUM ON THE SELENOCYSTEYL-TRANSFER RNA[SER]SEC POPULATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV CHICAGO,CHICAGO,IL 60637.
   NCI,LEC,BETHESDA,MD 20892.
   VANDERBILT UNIV,NASHVILLE,TN 37240.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A490
EP A490
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002815
ER

PT J
AU CIOLINO, HP
   LEVINE, RL
AF CIOLINO, HP
   LEVINE, RL
TI METAL-CATALYZED OXIDATIVE MODIFICATION OF PROTEINS OF ENDOTHELIAL-CELLS
   INVITRO
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,DEPT BIOCHEM,BETHESDA,MD 20892.
RI Levine, Rodney/D-9885-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A182
EP A182
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001042
ER

PT J
AU CO, D
   NORMAN, S
   FEDERICO, R
   SOMMERCORN, J
AF CO, D
   NORMAN, S
   FEDERICO, R
   SOMMERCORN, J
TI EVIDENCE FOR A NOVEL PROTEIN TYROSINE PHOSPHATASE IN HUMAN
   SKELETAL-MUSCLE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,PHOENIX,AZ 85016.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A337
EP A337
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001930
ER

PT J
AU COHEN, BE
   LEE, G
   POLLARD, HB
AF COHEN, BE
   LEE, G
   POLLARD, HB
TI CAMP AND ATP DIFFERENTIALLY AFFECT ACTIVITY AND COOPERATIVITY OF
   LIPOCORTIN-I (ANNEXIN-I) DRIVEN CHROMAFFIN GRANULE AND PS LIPOSOME
   AGGREGATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV VENEZUELA,FAC SCI,CARACAS,VENEZUELA.
   NIDDK,CELL BIOL & GENET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A420
EP A420
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002409
ER

PT J
AU COLOMBO, MF
   RAU, DC
AF COLOMBO, MF
   RAU, DC
TI MEASURED CHANGES IN PROTEIN HYDRATION IN THE MOLTEN GLOBULE TO RANDOM
   COIL TRANSITION OF APOMYOGLOBIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV NACL ESTADUAL SAO PAULO,IBILCE,DEPT FIS,SAO JOSE RIO PRE,SP,BRAZIL.
   NIDDK,LBM,BETHESDA,MD 20892.
RI Colombo, Marcio/K-5229-2013
OI Colombo, Marcio/0000-0003-3035-3926
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A344
EP A344
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001972
ER

PT J
AU COLOMBO, MF
   RAU, D
   PARSEGIAN, VA
AF COLOMBO, MF
   RAU, D
   PARSEGIAN, VA
TI REVEALING THE WATER CONTRIBUTION TO THE OBSERVED CHLORIDE EFFECT IN
   HEMOGLOBIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,LBM,BETHESDA,MD 20832.
RI Colombo, Marcio/K-5229-2013
OI Colombo, Marcio/0000-0003-3035-3926
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A56
EP A56
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000318
ER

PT J
AU COOK, JC
   CHOCK, PB
AF COOK, JC
   CHOCK, PB
TI CHARACTERIZATION OF E1 ISOFORMS BY IMMUNOCHEMICAL METHODS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,DEPT BIOCHEM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A183
EP A183
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001043
ER

PT J
AU CUDA, G
   COLLINS, K
   MATSUDAIRA, PT
   SELLERS, JR
AF CUDA, G
   COLLINS, K
   MATSUDAIRA, PT
   SELLERS, JR
TI PROBING MECHANICAL INTERACTIONS OF ACTIN AND MYOSIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 MIT,WHITEHEAD INST,CAMBRIDGE,MA 02142.
   NHLBI,BETHESDA,MD 20892.
RI Cuda, Giovanni/F-5359-2012
OI Cuda, Giovanni/0000-0001-6313-1866
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A439
EP A439
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002515
ER

PT J
AU DILISA, F
   GAMBASSI, G
   HANSFORD, RG
AF DILISA, F
   GAMBASSI, G
   HANSFORD, RG
TI UNCOUPLING AGENTS MAY INCREASE OR DECREASE MITOCHONDRIAL FREE CA2+ IN
   CARDIAC MYOCYTES, DEPENDING UPON STIMULATION FREQUENCY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A165
EP A165
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000943
ER

PT J
AU DIMITROV, DS
   GOLDING, H
   BLUMENTHAL, R
AF DIMITROV, DS
   GOLDING, H
   BLUMENTHAL, R
TI LONG-LIVED FUSOGENIC STATE OF THE HIV-1 ENVELOPE GLYCOPROTEIN EXPRESSED
   ON CELL-SURFACES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   US FDA,CBER,DIV VIROL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A421
EP A421
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002414
ER

PT J
AU DIMITROV, DS
   HILLMAN, K
   MANISCHEWITZ, J
   BLUMENTHAL, R
   GOLDING, H
AF DIMITROV, DS
   HILLMAN, K
   MANISCHEWITZ, J
   BLUMENTHAL, R
   GOLDING, H
TI KINETICS OF SCD4 BINDING TO CELLS EXPRESSING HIV-1 ENVELOPE GLYCOPROTEIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   US FDA,CBER,DIV VIROL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A262
EP A262
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001509
ER

PT J
AU DONG, C
AF DONG, C
TI AN ACTIN NETWORK MODEL FOR PSEUDOPOD PROTRUSION IN TUMOR-CELL METASTASIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A417
EP A417
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002389
ER

PT J
AU DONG, C
   CHADWICK, R
   SCHECHTER, AN
AF DONG, C
   CHADWICK, R
   SCHECHTER, AN
TI RHEOLOGICAL IMPORTANCE OF THE POLYMER FRACTION AND MEMBRANE RIGIDITY TO
   SICKLE-CELL DEFORMABILITY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCRR,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892.
   NIDDK,CHEM BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A523
EP A523
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44003010
ER

PT J
AU DRAGNEV, K
   LUBET, RA
   NERURKAR, P
AF DRAGNEV, K
   LUBET, RA
   NERURKAR, P
TI INDUCTION OF CYP1A1 AND CYP1A2 AS ASSESSED BY ENZYMOLOGY AND RNA
   QUANTITATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A456
EP A456
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002612
ER

PT J
AU DURELL, SR
   GUY, HR
AF DURELL, SR
   GUY, HR
TI ATOMIC SCALE MODELS OF THE SHAKER POTASSIUM CHANNEL
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,MATH BIOL LAB,BETHESDA,MD 20892.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A379
EP A379
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002172
ER

PT J
AU EHRLICH, A
   BARNETT, VA
   SCHOENBERG, M
AF EHRLICH, A
   BARNETT, VA
   SCHOENBERG, M
TI STOICHIOMETRY OF ALKYLATING AGENT REACTIVITY IN MUSCLE-FIBERS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS,LPB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A295
EP A295
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001683
ER

PT J
AU EIDELMAN, O
   GUAYBRODER, C
   VANGALEN, PJM
   JACOBSON, KA
   FOX, C
   CABANTCHIK, ZI
   TURNER, RJ
   POLLARD, HB
AF EIDELMAN, O
   GUAYBRODER, C
   VANGALEN, PJM
   JACOBSON, KA
   FOX, C
   CABANTCHIK, ZI
   TURNER, RJ
   POLLARD, HB
TI ACTIVATION OF CHLORIDE EFFLUX FROM CYSTIC-FIBROSIS CELLS BY
   ADENOSINE-A1-RECEPTOR ANTAGONISTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,CIPCB,BETHESDA,MD 20892.
   NIDDKD,LCBG,BETHESDA,MD.
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A537
EP A537
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44003090
ER

PT J
AU ENGLANDER, EW
   WILSON, SH
AF ENGLANDER, EW
   WILSON, SH
TI THE CLONED HUMAN BETA-POL PROMOTER IS ACTIVATED BY MNNG TREATMENT IN
   WILD-TYPE BUT NOT IN PROTEIN KINASE-A-DEFICIENT CHINESE-HAMSTER OVARY
   CELL-LINES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A69
EP A69
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000396
ER

PT J
AU FALETTO, MB
   ROMKESSPARKS, M
   RAUCY, JL
   LASKER, JM
   GOLDSTEIN, JA
AF FALETTO, MB
   ROMKESSPARKS, M
   RAUCY, JL
   LASKER, JM
   GOLDSTEIN, JA
TI EXPRESSION AND METABOLISM STUDIES OF THE HUMAN P4502C SUBFAMILY IN YEAST
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
   UNIV NEW MEXICO,COLL PHARM,ALBUQUERQUE,NM 87131.
   MT SINAI MED SCH,BRONX,NY 10148.
   VET ADM MED CTR,BRONX,NY 10148.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A322
EP A322
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001842
ER

PT J
AU FEDARKO, NS
   TERMINE, JD
   ROBEY, PG
AF FEDARKO, NS
   TERMINE, JD
   ROBEY, PG
TI OSTEONECTIN EXISTS IN 2 DISTINCT METABOLIC POOLS AND BINDS GTP
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 ELI LILLY & CO,INDIANAPOLIS,IN 46285.
   NIDR,BONE RES BRANCH,BETHESDA,MD 20892.
RI Robey, Pamela/H-1429-2011
OI Robey, Pamela/0000-0002-5316-5576
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A231
EP A231
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001329
ER

PT J
AU FISHER, MT
AF FISHER, MT
TI CHARACTERIZATION OF TRANSIENT ASSEMBLY INTERMEDIATES FORMED DURING GROEL
   ASSISTED RENATURATION OF DODECAMERIC GLUTAMINE-SYNTHETASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A49
EP A49
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000278
ER

PT J
AU FISHER, MT
AF FISHER, MT
TI GROES ACCELERATION OF THE GROEL-DEPENDENT RENATURATION OF DODECAMERIC
   GLUTAMINE-SYNTHETASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A49
EP A49
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000276
ER

PT J
AU FLEISCHER, B
   MCINTYRE, JO
   KEMPNER, ES
AF FLEISCHER, B
   MCINTYRE, JO
   KEMPNER, ES
TI TARGET SIZES OF GALACTOSYLTRANSFERASE, SIALYL-TRANSFERASE, AND URIDINE
   DIPHOSPHATASE IN GOLGI MEMBRANES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 VANDERBILT UNIV,DEPT MOLEC BIOL,NASHVILLE,TN 37235.
   NIAMS,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A92
EP A92
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000529
ER

PT J
AU FROEHLICH, J
   FENDLER, K
   GRELL, E
AF FROEHLICH, J
   FENDLER, K
   GRELL, E
TI THE ELECTROGENIC REACTION IN PIG-KIDNEY NA,K-ATPASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,BALTIMORE,MD 21224.
   MAX PLANCK INST BIOPHYS,W-6000 FRANKFURT 70,GERMANY.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A122
EP A122
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000705
ER

PT J
AU GARCIA, GE
   STADTMAN, TC
AF GARCIA, GE
   STADTMAN, TC
TI EXPRESSION OF THE SELENOPROTEIN A GENE OF THE GLYCINE REDUCTASE COMPLEX
   FROM CLOSTRIDIUM-STICKLANDII IN ESCHERICHIA-COLI
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A217
EP A217
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001245
ER

PT J
AU GAWRISCH, K
   JONES, TH
   FERRETTI, JA
AF GAWRISCH, K
   JONES, TH
   FERRETTI, JA
TI DISSOCIATION OF AMINO-ACIDS INCORPORATED INTO THE PHOSPHOLIPID WATER
   INTERFACE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A87
EP A87
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000503
ER

PT J
AU GOODMAN, SD
   NASH, HA
AF GOODMAN, SD
   NASH, HA
TI ESCHERICHIA-COLI INTEGRATION HOST FACTOR (IHF) CAN BE REPLACED BY
   HETEROLOGOUS BENDS IN EXCISION OF BACTERIOPHAGE-LAMBDA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A139
EP A139
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000798
ER

PT J
AU GRAHAME, DA
AF GRAHAME, DA
TI CLEAVAGE OF ACETYL-COA BY A CARBON-MONOXIDE DEHYDROGENASE-CORRINOID
   ENZYME COMPLEX
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A331
EP A331
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001897
ER

PT J
AU HAN, H
   RIFKIND, JM
   MILDVAN, AS
AF HAN, H
   RIFKIND, JM
   MILDVAN, AS
TI ROLE OF DIVALENT-CATIONS IN THE 3',5'-EXONUCLEASE REACTION OF
   DNA-POLYMERASE-I
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205.
   NIH,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A461
EP A461
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002644
ER

PT J
AU HAN, MK
   GINSBURG, A
AF HAN, MK
   GINSBURG, A
TI XENOPUS TRANSCRIPTION FACTOR (TFIIIA) - FLUORESCENCE STUDIES OF TFIIIA
   AND DNA INTERACTIONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A486
EP A486
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002794
ER

PT J
AU HANOVER, JA
AF HANOVER, JA
TI THE ROLE OF THE NUCLEAR-PORE IN NUCLEAR-PROTEIN TARGETING
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BIOCHEM & METAB LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A138
EP A138
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000795
ER

PT J
AU HARMON, PA
   HENDLER, RW
   LEVIN, IW
AF HARMON, PA
   HENDLER, RW
   LEVIN, IW
TI RESONANCE RAMAN INVESTIGATION OF THE THERMODYNAMIC MIDPOINT POTENTIALS
   OF THE HEME-A CHROMOPHORES IN CYTOCHROME-OXIDASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
ID REDOX PROPERTIES
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
   NHLBI,CELL BIOL LAB,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A193
EP A193
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001104
ER

PT J
AU HAUN, RS
   MOSS, J
AF HAUN, RS
   MOSS, J
TI LIGATION-INDEPENDENT CLONING OF GLUTATHIONE-S-TRANSFERASE FUSION
   PROTEINS FOR EXPRESSION IN ESCHERICHIA-COLI
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A76
EP A76
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000433
ER

PT J
AU HENRY, ER
   SZABO, A
   EATON, WA
AF HENRY, ER
   SZABO, A
   EATON, WA
TI MOLECULAR-DYNAMICS SIMULATIONS OF HEME MOTION IN MYOGLOBIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A54
EP A54
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000303
ER

PT J
AU HOMSHER, E
   WANG, F
   SELLERS, J
AF HOMSHER, E
   WANG, F
   SELLERS, J
TI THE EFFECT OF WEAKLY ATTACHED CROSS BRIDGES ON ACTIN FILAMENT SLIDING
   VELOCITY IN THE INVITRO MOTILITY ASSAY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV CALIF LOS ANGELES,SCH MED,DEPT PHYSIOL,LOS ANGELES,CA 90024.
   NIH,DIV MOLEC CARDIOL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A439
EP A439
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002517
ER

PT J
AU HOWLEY, P
   MUNGER, K
   SCHEFFNER, M
   HUIBREGTSE, JM
AF HOWLEY, P
   MUNGER, K
   SCHEFFNER, M
   HUIBREGTSE, JM
TI CELLULAR TARGETS OF THE ONCOPROTEINS ENCODED BY THE CANCER ASSOCIATED
   HUMAN PAPILLOMAVIRUSES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A1
EP A1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000002
ER

PT J
AU HUSSEY, DM
   SHARROCK, W
   BANASZAK, LJ
AF HUSSEY, DM
   SHARROCK, W
   BANASZAK, LJ
TI THE SEQUENCE OF LAMPREY VITELLOGENIN - COMPARISON WITH OTHER
   VITELLOGENINS - COMPARISON OF PRIMARY, SECONDARY, AND TERTIARY STRUCTURE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455.
   NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A348
EP A348
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001993
ER

PT J
AU IKURA, M
   KAY, LE
   BARBATO, G
   SPERA, S
   BAX, A
AF IKURA, M
   KAY, LE
   BARBATO, G
   SPERA, S
   BAX, A
TI MULTIDIMENSIONAL NMR-STUDIES ON CALMODULIN AND ITS COMPLEX WITH A
   SKELETAL-MUSCLE MYOSIN LIGHT-CHAIN KINASE FRAGMENT
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
RI Barbato, Gaetano/G-4904-2011
NR 0
TC 1
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A403
EP A403
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002316
ER

PT J
AU IWAMOTO, H
   PODOLSKY, RJ
AF IWAMOTO, H
   PODOLSKY, RJ
TI CHANGES IN THE ELASTIC PROPERTIES OF COVALENTLY CROSS-LINKED ACTOMYOSIN
   COMPLEX UPON WEAK-TO-STRONG TRANSITION - IMPLICATIONS FOR THE MECHANISM
   OF MUSCLE-CONTRACTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS,LPB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A293
EP A293
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001673
ER

PT J
AU IWASA, KH
   TACHIBANA, M
AF IWASA, KH
   TACHIBANA, M
TI AMILORIDE-SENSITIVE SODIUM-CHANNELS IN THE MARGINAL CELL IN THE
   STRIA-VASCULARIS OF THE COCHLEA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDCD,CELLULAR BIOL LAB,BETHESDA,MD 20892.
   NIDCD,MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A517
EP A517
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002976
ER

PT J
AU IWASAKI, M
   LINDBERG, R
   JUVONEN, R
   NEGISHI, M
AF IWASAKI, M
   LINDBERG, R
   JUVONEN, R
   NEGISHI, M
TI BINDING ORIENTATION OF STEROID TOWARD RESIDUE-209 IN MOUSE STEROID
   7-ALPHA-HYDROXYLASES AND 15-ALPHA-HYDROXYLASES (CYTOCHROME-P4507-ALPHA
   AND CYTOCHROME-P45015-ALPHA)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A320
EP A320
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001831
ER

PT J
AU JANCZEWSKI, AM
   SPURGEON, HA
   LAKATTA, EG
AF JANCZEWSKI, AM
   SPURGEON, HA
   LAKATTA, EG
TI THAPSIGARGIN (TG) INHIBITS SARCOPLASMIC-RETICULUM (SR) CA2+ UPTAKE IN
   ISOLATED CARDIAC MYOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A22
EP A22
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000119
ER

PT J
AU JONES, CR
   GUENGERICH, FP
   RICE, JM
   LUBET, RA
AF JONES, CR
   GUENGERICH, FP
   RICE, JM
   LUBET, RA
TI INDUCTION OF DRUG-METABOLIZING-ENZYMES BY PHENOBARBITAL IN
   ERYTHROCEBUS-PATAS AND MACACA-FASCICULARIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,DYNA CORP,FREDERICK,MD 21702.
   NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702.
   VANDERBILT UNIV,NASHVILLE,TN 37240.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A198
EP A198
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001132
ER

PT J
AU JUVONEN, RO
   IWASAKI, M
   NEGISHI, M
AF JUVONEN, RO
   IWASAKI, M
   NEGISHI, M
TI IDENTIFICATION OF RESIDUE-129 IN MOUSE P450COH AS A CYTOCHROME-B5
   BINDING-SITE AND ROLE OF RESIDUE-209 IN CYTOCHROME-B5-DEPENDENT
   STIMULATION OF MONOOXYGENASE ACTIVITIES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A320
EP A320
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001828
ER

PT J
AU KALOSS, WD
   CONNAUGHTON, JF
   VANEK, PG
   CHIRIKJIAN, JG
AF KALOSS, WD
   CONNAUGHTON, JF
   VANEK, PG
   CHIRIKJIAN, JG
TI CHARACTERIZATION OF OVEREXPRESSED BAM H-II METHYLASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 GEORGETOWN UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOL,WASHINGTON,DC 20007.
   NCI,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A217
EP A217
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001244
ER

PT J
AU KARLSTROM, AR
   SHAMES, BD
   LEVINE, RL
AF KARLSTROM, AR
   SHAMES, BD
   LEVINE, RL
TI REACTIVITY OF CYSTEINE RESIDUES IN THE HIV-1 PROTEASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
RI Levine, Rodney/D-9885-2011
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A324
EP A324
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001854
ER

PT J
AU KAWAMOTO, S
AF KAWAMOTO, S
TI STUDIES ON THE PROMOTER REGION OF THE HUMAN NONMUSCLE MYOSIN HEAVY
   CHAIN-A GENE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A74
EP A74
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000422
ER

PT J
AU KELLER, SL
   BEZRUKOV, SM
   GRUNER, SM
   VODYANOY, I
   PARSEGIAN, VA
AF KELLER, SL
   BEZRUKOV, SM
   GRUNER, SM
   VODYANOY, I
   PARSEGIAN, VA
TI RELATIVE PROBABILITY OF ALAMETHICIN CONDUCTANCE STATES VARIES WITH LIPID
   SPONTANEOUS CURVATURE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV MARYLAND,COLLEGE PK,MD 20742.
   PRINCETON UNIV,PRINCETON,NJ 08544.
   USN,OFF RES,ARLINGTON,VA 22217.
   NIH,BETHESDA,MD 20892.
RI Gruner, Sol/G-2924-2010
OI Gruner, Sol/0000-0002-1171-4426
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A115
EP A115
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000663
ER

PT J
AU KIM, MG
   HSIEH, P
   CAMERINIOTERO, CS
   RAGHUNATHAN, G
   JERNIGAN, RL
   ZHURKIN, VB
   CAMERINIOTERO, RD
AF KIM, MG
   HSIEH, P
   CAMERINIOTERO, CS
   RAGHUNATHAN, G
   JERNIGAN, RL
   ZHURKIN, VB
   CAMERINIOTERO, RD
TI RECOMBINATION PROTEIN MEDIATED TRIPLEX DNA - R-FORM DNA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,GENET & BIOCHEM BRANCH,BETHESDA,MD 20892.
   NCI,MATH BIOL LAB,BETHESDA,MD 20892.
RI Jernigan, Robert/A-5421-2012
NR 0
TC 3
Z9 3
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A481
EP A481
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002765
ER

PT J
AU KIM, SJ
   LEWIS, MS
   PORTER, D
   KNUTSON, JR
   KUMAR, A
   WILSON, SH
AF KIM, SJ
   LEWIS, MS
   PORTER, D
   KNUTSON, JR
   KUMAR, A
   WILSON, SH
TI FLUORESCENCE AND HYDRODYNAMIC PROPERTIES OF RAT BETA-POLYMERASE -
   MOLECULAR ASYMMETRY AND METAL-INDUCED CONFORMATIONAL CHANGE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
   NHLBI,CELL BIOL LAB,BETHESDA,MD 20892.
   NIH,NCRR,BIOMED ENGN INST PROGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A474
EP A474
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002720
ER

PT J
AU KLEINER, DE
   UNSWORTH, EJ
   KRUTZSCH, HC
   STETLERSTEVENSON, WG
AF KLEINER, DE
   UNSWORTH, EJ
   KRUTZSCH, HC
   STETLERSTEVENSON, WG
TI DEMONSTRATION OF 2 INTERACTING BINDING-SITES FOR TIMP-2 TO THE 72-KD
   TYPE-IV COLLAGENASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A352
EP A352
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002018
ER

PT J
AU KOCSIS, E
   KESSEL, M
   TRUS, BL
   SMITH, PR
   BRENNAN, M
   STEVEN, AC
AF KOCSIS, E
   KESSEL, M
   TRUS, BL
   SMITH, PR
   BRENNAN, M
   STEVEN, AC
TI 3-DIMENSIONAL RECONSTRUCTION OF THE NATURALLY CRYSTALLINE PORIN IN THE
   OUTER-MEMBRANE OF AN AVIRULENT STRAIN OF BORDETELLA-PERTUSSIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NYU MED CTR,DEPT CELL BIOL,NEW YORK,NY 10016.
   NIAMS,STRUCT BIOL RES LAB,BETHESDA,MD 20892.
   NIH,DCRT,COMP SYST LAB,BETHESDA,MD 20892.
   US FDA,DIV BACTERIAL PROD,BETHESDA,MD 20014.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A10
EP A10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000053
ER

PT J
AU KONG, SK
   CHOCK, PB
AF KONG, SK
   CHOCK, PB
TI PHOSPHORYLATION OF AN UBIQUITIN CARRIER ENZYME BY A PROTEIN-KINASE FROM
   HELA-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A183
EP A183
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001046
ER

PT J
AU KUMAR, A
   CASASFINET, JR
   KARPEL, RL
   WIDEN, SG
   WILSON, SH
AF KUMAR, A
   CASASFINET, JR
   KARPEL, RL
   WIDEN, SG
   WILSON, SH
TI DOMAIN-STRUCTURE OF MAMMALIAN DNA-POLYMERASE BETA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
   UNIV MARYLAND,DEPT CHEM & BIOCHEM,CATONSVILLE,MD 21228.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A60
EP A60
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000342
ER

PT J
AU LEE, CM
   HAUN, RS
   TSAI, SC
   MOSS, J
   VAUGHAN, M
AF LEE, CM
   HAUN, RS
   TSAI, SC
   MOSS, J
   VAUGHAN, M
TI ISOLATION AND CHARACTERIZATION OF THE HUMAN GENE ENCODING
   ADP-RIBOSYLATION FACTOR-I, A APPROXIMATELY 20 KDA GUANINE
   NUCLEOTIDE-BINDING PROTEIN ACTIVATOR FOR CHOLERA-TOXIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A98
EP A98
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000569
ER

PT J
AU LEE, HG
   JARRETT, HW
   KOSKKOSICKA, D
   KRINKS, MH
   PERSECHINI, A
AF LEE, HG
   JARRETT, HW
   KOSKKOSICKA, D
   KRINKS, MH
   PERSECHINI, A
TI ACTIVATION OF ENZYMES BY CROSS-LINKED CALMODULINS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,DEPT ANESTHESIOL,BALTIMORE,MD 21205.
   UNIV ROCHESTER,DEPT PHYSIOL,ROCHESTER,NY 14642.
   UNIV TENNESSEE,DEPT BIOCHEM,MEMPHIS,TN 38138.
   NCI,BIOCHEM LAB,BETHESDA,MD 20014.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A336
EP A336
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001923
ER

PT J
AU LEE, YC
   DRISCOLL, WJ
   OEDA, T
   STROTT, CA
AF LEE, YC
   DRISCOLL, WJ
   OEDA, T
   STROTT, CA
TI PURIFICATION AND IDENTIFICATION OF THE FACTOR THAT MODULATES BINDING OF
   PREGNENOLONE TO A SPECIFIC PROTEIN IN THE ADRENAL-CORTEX
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,ERRB,ADRENAL CELL BIOL SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A198
EP A198
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001133
ER

PT J
AU LEIKIN, S
   PARSEGIAN, VA
AF LEIKIN, S
   PARSEGIAN, VA
TI A MECHANISM FOR TEMPERATURE-FAVORED PROTEIN ASSEMBLY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A418
EP A418
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002395
ER

PT J
AU LEIKIN, S
   RAU, DC
AF LEIKIN, S
   RAU, DC
TI HYDRATION FORCES IN MACROMOLECULAR ASSEMBLIES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A278
EP A278
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001590
ER

PT J
AU LEIKINA, E
   ZIMMERBERG, J
AF LEIKINA, E
   ZIMMERBERG, J
TI ACIDIC PH INDUCES FUSION OF CELLS INFECTED WITH BACULOVIRUS TO FORM
   SYNCYTIA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,THEORET & PHYS BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A499
EP A499
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002869
ER

PT J
AU LEWIS, EN
   TREADO, PJ
   LEVIN, IW
AF LEWIS, EN
   TREADO, PJ
   LEVIN, IW
TI VISIBLE/NEAR-INFRARED IMAGING SPECTROMETRY - APPLICATIONS OF AN
   ACOUSTOOPTIC TUNABLE FILTER (AOTF) TO BIOLOGICAL MICROSCOPY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A34
EP A34
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000189
ER

PT J
AU LEWIS, MS
   KIM, SJ
   KUMAR, A
   WILSON, SH
AF LEWIS, MS
   KIM, SJ
   KUMAR, A
   WILSON, SH
TI THERMODYNAMIC PARAMETERS OF OLIGODEOXYNUCLEOTIDE BINDING TO DNA
   BETA-POLYMERASE REVEALED BY EQUILIBRIUM ULTRACENTRIFUGATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892.
   NCI,BIOCHEM LAB,BETHESDA,MD 20892.
RI kumari, uttara/P-6779-2016
OI kumari, uttara/0000-0001-9628-4770
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A489
EP A489
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002809
ER

PT J
AU LI, M
   JIA, M
   IWASA, KH
AF LI, M
   JIA, M
   IWASA, KH
TI EFFECT OF GD(3+) ON THE MAMMALIAN AUDITORY OUTER HAIR-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NINCDS,BIOPHYS LAB,BETHESDA,MD 20892.
   NIDCD,CELLULAR BIOL LAB,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A518
EP A518
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002977
ER

PT J
AU LIAO, F
   SHIN, HS
   RHEE, SG
AF LIAO, F
   SHIN, HS
   RHEE, SG
TI TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-1 INDUCED BY
   CROSS-LINKING OF FCR-GAMMA-RI OR FC-GAMMA-RII IN U937 CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GENET,BALTIMORE,MD 21205.
   NHLBI,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A369
EP A369
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002115
ER

PT J
AU LIN, XL
   LIN, YZ
   KOELSCH, G
   GUSTCHINA, A
   WLODAWER, A
   TANG, J
AF LIN, XL
   LIN, YZ
   KOELSCH, G
   GUSTCHINA, A
   WLODAWER, A
   TANG, J
TI 2-CHAIN PEPSINOGEN HETERODIMER AND HOMODIMER - MODELS FOR COMPARISONS TO
   THE ASPARTIC PROTEASE OF HUMAN-IMMUNODEFICIENCY-VIRUS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702.
   UNIV OKLAHOMA,HLTH SCI CTR,OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK 73190.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A458
EP A458
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002627
ER

PT J
AU LUSTIG, B
   COVELL, DG
   JERNIGAN, RL
AF LUSTIG, B
   COVELL, DG
   JERNIGAN, RL
TI LATTICE METHOD FOR CONFORMATION GENERATION OF RNA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,DCBDC,LMMB,BETHESDA,MD 20892.
   ASCL,PRI,FCRDC,FREDERICK,MD 21702.
RI Jernigan, Robert/A-5421-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A150
EP A150
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000856
ER

PT J
AU MALINCHIK, SB
AF MALINCHIK, SB
TI THICK FILAMENT MODEL CONSISTENT WITH THE X-RAY-DIFFRACTION PATTERN OF
   RELAXED STRIATED-MUSCLE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 ACAD SCI USSR,INST BIOPHYS,PUSHCHINO 142292,USSR.
   NIAMS,LPB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A301
EP A301
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001717
ER

PT J
AU MARTINEZ, M
   PRICE, SR
   MOSS, J
   ALVAREZGONZALEZ, R
AF MARTINEZ, M
   PRICE, SR
   MOSS, J
   ALVAREZGONZALEZ, R
TI CHOLERA TOXIN-CATALYZED ADP-RIBOSYLATION OF POLY(ADP-RIBOSE)POLYMERASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV N TEXAS,TEXAS COLL OSTEOPATH MED,DEPT MICROBIOL,FT WORTH,TX 76107.
   NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A35
EP A35
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000195
ER

PT J
AU MCDONALD, LJ
   WAINSCHEL, L
   OPPENHEIMER, NJ
   MOSS, J
AF MCDONALD, LJ
   WAINSCHEL, L
   OPPENHEIMER, NJ
   MOSS, J
TI NONENZYMATIC ADP-RIBOSYLATION OF CYSTEINE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT SCI,SAN FRANCISCO,CA 94143.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A184
EP A184
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001051
ER

PT J
AU MCKINNEY, CE
   GINNS, EI
AF MCKINNEY, CE
   GINNS, EI
TI TARGETING OF ACTIVE BETA-GLUCOCEREBROSIDASE TO HEPG2 HEPATOCYTES VIA THE
   ASIALOGLYCOPROTEIN RECEPTOR
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A485
EP A485
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002784
ER

PT J
AU MIELE, EC
   MIELE, L
   MUKHERJEE, AB
AF MIELE, EC
   MIELE, L
   MUKHERJEE, AB
TI INHIBITION OF PORCINE PANCREATIC PHOSPHOLIPASE-A2 BY A MONOSPECIFIC
   ANTIBODY - MECHANISM OF ACTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,HGB,DEV GENET SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A333
EP A333
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001910
ER

PT J
AU MIELE, L
   CORDELLAMIELE, E
   BENINATI, S
   MUKHERJEE, AB
AF MIELE, L
   CORDELLAMIELE, E
   BENINATI, S
   MUKHERJEE, AB
TI ACTIVATION OF PORCINE PANCREATIC PHOSPHOLIPASE-A2 BY
   TRANSGLUTAMINASE-MEDIATED POLYAMINATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,DEV GENET SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A184
EP A184
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001049
ER

PT J
AU MINTON, AP
AF MINTON, AP
TI CONFINEMENT BY FIBROUS ELEMENTS OF THE CYTOMATRIX INFLUENCES ASSOCIATION
   EQUILIBRIA IN THE FLUID PHASE OF CYTOPLASM
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BIOCHEM PHARMACOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A215
EP A215
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001234
ER

PT J
AU MISCHAK, H
   PIERCE, JH
   GOODNIGHT, J
   MUSHINSKI, JF
AF MISCHAK, H
   PIERCE, JH
   GOODNIGHT, J
   MUSHINSKI, JF
TI OVEREXPRESSION OF PROTEIN KINASE-C-ALPHA (PKC-ALPHA) INDUCES PHORBOL
   ESTER (PMA)-DEPENDENT DIFFERENTIATION IN MYELOID CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
RI Mischak, Harald/E-8685-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A452
EP A452
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002594
ER

PT J
AU MITAS, M
   CHIN, H
   NIRENBERG, M
AF MITAS, M
   CHIN, H
   NIRENBERG, M
TI REGULATION OF THE EXPRESSION OF A GENE FOR A CALCIUM-CHANNEL ALPHA-1
   SUBUNIT
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   NINCDS,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A407
EP A407
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002339
ER

PT J
AU MOUSSAVI, RS
   ADELSTEIN, RS
AF MOUSSAVI, RS
   ADELSTEIN, RS
TI PHOSPHORYLATION OF MYOSIN IN HUMAN LYMPHOCYTES-T
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A298
EP A298
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001702
ER

PT J
AU NICHOLSON, L
   CROSS, T
   DEMURA, M
   ASAKURA, T
AF NICHOLSON, L
   CROSS, T
   DEMURA, M
   ASAKURA, T
TI A METHOD FOR STUDYING THE STRUCTURE OF UNIAXIALLY ALIGNED
   MOLECULAR-SYSTEMS USING SOLID-STATE NMR - APPLICATION TO SILK FIBROIN
   FIBERS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
   FLORIDA STATE UNIV,DEPT CHEM,TALLAHASSEE,FL 32306.
   TOKYO UNIV AGR & TECHNOL,DEPT BIOTECHNOL,KOGANEI,TOKYO 184,JAPAN.
RI Demura, Makoto/F-5272-2011; Asakura, Tetsuo/B-9970-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A341
EP A341
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001954
ER

PT J
AU NIEBYLSKI, CD
   SALEM, N
AF NIEBYLSKI, CD
   SALEM, N
TI A TIME-RESOLVED FLUORESCENCE SPECTROSCOPIC COMPARISON OF
   PHOSPHOLIPID-BILAYERS CONTAINING OLEIC, ARACHIDONIC, EICOSAPENTAENOIC
   AND DOCOSAHEXAENOIC PHOSPHOLIPIDS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA,ADAMHA,DICBR,MEMBRANE BIOCHEM & BIOPHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A238
EP A238
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001364
ER

PT J
AU NUSSINOV, R
   FISCHER, D
   WOLFSON, H
AF NUSSINOV, R
   FISCHER, D
   WOLFSON, H
TI A COMPUTER VISION BASED 3-DIMENSIONAL APPROACH FOR THE COMPARISON OF
   PROTEIN STRUCTURES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,MATH BIOL LAB,FREDERICK,MD 21701.
   TEL AVIV UNIV,SCH MED,IL-69978 TEL AVIV,ISRAEL.
   TEL AVIV UNIV,DEPT COMP SCI,IL-69978 TEL AVIV,ISRAEL.
   NYU,COURANT INST MATH SCI,ROBOT RES LAB,NEW YORK,NY 10012.
RI Wolfson, Haim/A-1837-2011
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A349
EP A349
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001998
ER

PT J
AU OEDA, T
   LEE, YC
   DRISCOLL, WJ
   CHEN, H
   STROTT, CA
AF OEDA, T
   LEE, YC
   DRISCOLL, WJ
   CHEN, H
   STROTT, CA
TI MOLECULAR-CLONING OF A CDNA FOR THE GUINEA-PIG ADRENOCORTICAL
   PREGNENOLONE-BINDING PROTEIN - THE DEDUCED AMINO-ACID-SEQUENCE IS
   HOMOLOGOUS TO BOVINE PLACENTAL ESTROGEN SULFOTRANSFERASE AND THE
   EXPRESSED PROTEIN EXHIBITS ENZYMATIC-ACTIVITY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,ERRB,ADRENAL CELL BIOL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A198
EP A198
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001135
ER

PT J
AU OLIVARES, E
   ROJAS, E
AF OLIVARES, E
   ROJAS, E
TI THE RYANODINE RECEPTOR IN LOBSTER SARCOPLASMIC-RETICULUM MEMBRANES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CELL BIOL & GENET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A23
EP A23
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000130
ER

PT J
AU PARK, DG
   CHAE, HZ
   JHON, DY
   RHEE, SG
AF PARK, DG
   CHAE, HZ
   JHON, DY
   RHEE, SG
TI GQ ACTIVATES PLC-BETA-1 BUT NOT PLC-BETA-2 INVITRO
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A368
EP A368
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002110
ER

PT J
AU PARK, DG
   JHON, DY
   LEE, CW
   LEE, SY
   RHEE, SG
AF PARK, DG
   JHON, DY
   LEE, CW
   LEE, SY
   RHEE, SG
TI ACTIVATION OF DIFFERENT FORMS OF PLC-BETA-1 BY GQ
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   GYEONGSANG NATL UNIV,CHINJU,SOUTH KOREA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A368
EP A368
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002108
ER

PT J
AU PARK, DJ
   KIM, JW
   MIN, HK
   LEE, HB
   RHO, HW
   RHEE, SG
AF PARK, DJ
   KIM, JW
   MIN, HK
   LEE, HB
   RHO, HW
   RHEE, SG
TI IGE-INDUCED TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-1 IN RAT
   BASOPHILIC LEUKEMIA-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
   KYONGSANG NATL UNIV,CHINJU,SOUTH KOREA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A369
EP A369
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002112
ER

PT J
AU PARK, DJ
   MIN, HK
   CHOI, KD
   LEE, SB
   RHEE, SG
AF PARK, DJ
   MIN, HK
   CHOI, KD
   LEE, SB
   RHEE, SG
TI INHIBITION OF CD3-LINKED PLC-GAMMA-1 BY PHORBOL ESTER AND CAMP
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A368
EP A368
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002111
ER

PT J
AU PARK, JS
   FARGNOLI, J
   HOLBROOK, NJ
AF PARK, JS
   FARGNOLI, J
   HOLBROOK, NJ
TI IDENTIFICATION OF THE GADD153 PROTEIN AND SEQUENCE COMPARISON BETWEEN
   HAMSTER AND HUMAN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A74
EP A74
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000424
ER

PT J
AU PARSEGIAN, VA
   RAND, RP
AF PARSEGIAN, VA
   RAND, RP
TI WORKSHOP ON MOLECULAR HYDRATION AND HYDRATION FORCES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
   BROCK UNIV,ST CATHARINES L2S 3A1,ONTARIO,CANADA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A278
EP A278
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001589
ER

PT J
AU PASTAN, I
   GOTTESMAN, MM
AF PASTAN, I
   GOTTESMAN, MM
TI MOLECULAR-BIOLOGY OF A MULTIDRUG TRANSPORTER
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,DCBDC,CELL BIOL LAB,BETHESDA,MD 20892.
   NCI,DCBDC,MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A128
EP A128
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000737
ER

PT J
AU PHILLIPS, CL
   YAMAKAWA, K
   PRESTON, YA
   GOENS, MB
   ADELSTEIN, RS
AF PHILLIPS, CL
   YAMAKAWA, K
   PRESTON, YA
   GOENS, MB
   ADELSTEIN, RS
TI HUMAN NONMUSCLE MYOSIN HEAVY CHAIN-B - CLONING, EXPRESSION AND PROTEIN
   DISTRIBUTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A298
EP A298
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001704
ER

PT J
AU POSTON, JM
AF POSTON, JM
TI CHANGES IN ENZYME-ACTIVITIES AND ISOZYME DISTRIBUTION IN ISCHEMIC AND
   REPERFUSED RAT HEARTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A182
EP A182
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001040
ER

PT J
AU PRICE, SR
   NIGHTINGALE, MS
   MISHIMA, K
   MOSS, J
   VAUGHAN, M
AF PRICE, SR
   NIGHTINGALE, MS
   MISHIMA, K
   MOSS, J
   VAUGHAN, M
TI MOLECULAR MECHANISM RESPONSIBLE FOR THE TISSUE-SPECIFIC EXPRESSION OF
   MESSENGER-RNAS ENCODING THE APPROXIMATELY 20 KDA GUANINE
   NUCLEOTIDE-BINDING PROTEIN ADP-RIBOSYLATION FACTOR-IV - DEVELOPMENTAL
   REGULATION OF EXPRESSION IN TESTIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A450
EP A450
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002579
ER

PT J
AU PRIOR, TI
   FITZGERALD, DJ
   PASTAN, I
AF PRIOR, TI
   FITZGERALD, DJ
   PASTAN, I
TI PSEUDOMONAS EXOTOXIN-A CAN TRANSPORT FOREIGN PROTEINS INTO THE CYTOSOL
   OF TARGET-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A138
EP A138
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000793
ER

PT J
AU RAYMOND, GJ
   ERNST, D
   RACE, RE
   CAUGHEY, B
AF RAYMOND, GJ
   ERNST, D
   RACE, RE
   CAUGHEY, B
TI N-TERMINAL TRUNCATION OF THE SCRAPIE-ASSOCIATED FORM OF PRP BY LYSOSOMAL
   PROTEASES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,PERSISTENT VIRAL DIS LAB,ROCKY MT LABS,HAMILTON,MT 59840.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A517
EP A517
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002972
ER

PT J
AU REMETA, DP
   MILES, EW
   GINSBURG, A
AF REMETA, DP
   MILES, EW
   GINSBURG, A
TI THERMALLY INDUCED UNFOLDING OF THE TRYPTOPHAN SYNTHASE MULTIENZYME
   COMPLEX
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   NIDDK,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A213
EP A213
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001221
ER

PT J
AU RHEE, SG
AF RHEE, SG
TI REGULATION OF PHOSPHOLIPASE-C ISOZYMES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A276
EP A276
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001581
ER

PT J
AU RIFKIND, JM
   ABUGO, O
   LUMRY, R
AF RIFKIND, JM
   ABUGO, O
   LUMRY, R
TI NONLINEAR SPECTRAL CHANGES DURING HEMOGLOBIN OXYGENATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
   UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A55
EP A55
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000310
ER

PT J
AU RINAUDO, MS
   PARK, MH
AF RINAUDO, MS
   PARK, MH
TI CLONING AND SEQUENCING OF A CHICK-EMBRYO CDNA-ENCODING THE
   HYPUSINE-CONTAINING PROTEIN-EIF-5A
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A453
EP A453
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002597
ER

PT J
AU ROMKESSPARKS, M
   BLAISDELL, J
   YUN, CH
   GUENGERICH, FP
   GOLDSTEIN, JA
AF ROMKESSPARKS, M
   BLAISDELL, J
   YUN, CH
   GUENGERICH, FP
   GOLDSTEIN, JA
TI CORRELATION OF S-MEPHENYTOIN 4'-HYDROXYLASE ACTIVITY WITH EXPRESSION OF
   DIFFERENT MEMBERS OF THE P4502C SUBFAMILY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
   UNIV PITTSBURGH,DEPT ENVIRONM OCCUPAT HLTH,PITTSBURGH,PA 15261.
   VANDERBILT UNIV,MED CTR,SCH MED,NASHVILLE,TN 37232.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A321
EP A321
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001836
ER

PT J
AU RUBIN, RJ
   CHEN, YD
AF RUBIN, RJ
   CHEN, YD
TI THEORETICAL-STUDIES ON BULK DIFFUSION AND FLUORESCENCE DEQUENCHING IN
   CELL-CELL FUSION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A499
EP A499
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002871
ER

PT J
AU SAGI, I
   ARTHUR, LO
   HENDERSON, LE
   SUMMERS, MF
   BESS, JW
   CHANCE, MR
AF SAGI, I
   ARTHUR, LO
   HENDERSON, LE
   SUMMERS, MF
   BESS, JW
   CHANCE, MR
TI EXAFS STRUCTURE OF RETROVIRAL GAG ZINC FINGER PROTEIN-RNA COMPLEX IN
   INTACT RETROVIRAL PARTICLES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 GEORGETOWN UNIV,WASHINGTON,DC 20057.
   UNIV MARYLAND,COLLEGE PK,MD 20742.
   NCI,FREDRICK CANC RES & DEV CTR,BETHESDA,MD 20892.
RI Bess, Jr., Julian/B-5343-2012
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A488
EP A488
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002804
ER

PT J
AU SAWAZAKI, S
   KIM, HY
   SALEM, N
AF SAWAZAKI, S
   KIM, HY
   SALEM, N
TI LIPOXYGENATION OF DOCOSAHEXAENOIC ACID (22-6N3) BY RAT PINEAL-BODY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA,DICBR,LMBB,MASS SPECT SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A365
EP A365
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002094
ER

PT J
AU SAXENA, SK
   RYBAK, SM
   YOULE, RJ
   ACKERMAN, EJ
AF SAXENA, SK
   RYBAK, SM
   YOULE, RJ
   ACKERMAN, EJ
TI COMPARISON OF RNASES AND TOXINS UPON INJECTION INTO XENOPUS OOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
   NINCDS,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A66
EP A66
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000379
ER

PT J
AU SCHNEKENBUHL, S
   KRAFT, T
   YU, LC
   BRENNER, B
   CHALOVICH, JM
AF SCHNEKENBUHL, S
   KRAFT, T
   YU, LC
   BRENNER, B
   CHALOVICH, JM
TI EFFECT OF NEM-S-1 ON CROSS-BRIDGE ACTION IN SKINNED RABBIT PSOAS
   MUSCLE-FIBERS - BIOCHEMICAL, MECHANICAL, AND X-RAY-DIFFRACTION STUDIES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV ULM,W-7900 ULM,GERMANY.
   NIH,BETHESDA,MD 20892.
   E CAROLINA UNIV,GREENVILLE,NC 27834.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A292
EP A292
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001665
ER

PT J
AU SCHWALBE, RA
   DAHLBACK, B
   COE, JE
   NELSESTUEN, GL
AF SCHWALBE, RA
   DAHLBACK, B
   COE, JE
   NELSESTUEN, GL
TI THE PENTRAXIN FAMILY OF PROTEINS INTERACT SPECIFICALLY WITH
   PHOSPHORYLCHOLINE AND OR PHOSPHORYLETHANOLAMINE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV MINNESOTA,DEPT BIOCHEM,ST PAUL,MN 55108.
   UNIV LUND,MALMO GEN HOSP,DEPT CLIN CHEM,S-21401 MALMO,SWEDEN.
   NIAID,PERSISTENT VIRAL DIS LAB,HAMILTON,MT 59840.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A327
EP A327
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001872
ER

PT J
AU SCHWEIKL, H
   TAYLOR, J
   LINKO, P
   NAGORNY, D
   GOLDSTEIN, JA
AF SCHWEIKL, H
   TAYLOR, J
   LINKO, P
   NAGORNY, D
   GOLDSTEIN, JA
TI VARIABLE EXPRESSION OF CYTOCHROME-P4501A2 AND CYTOCHROME-P4501A1
   MESSENGER-RNAS IN HUMAN LIVER
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
   MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905.
RI Schweikl, Helmut/C-2998-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A457
EP A457
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002620
ER

PT J
AU SHAANAN, B
   LIS, H
   SHARON, N
AF SHAANAN, B
   LIS, H
   SHARON, N
TI STRUCTURE OF THE ERYTHRINA-CORALLODENDRON LECTIN AT 2.0-A RESOLUTION - A
   CASE-STUDY FOR PROTEIN-CARBOHYDRATE INTERACTIONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,LMB,BETHESDA,MD.
   WEIZMANN INST SCI,IL-76100 REHOVOT,ISRAEL.
RI Shaanan, Boaz/F-1202-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A540
EP A540
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44003108
ER

PT J
AU SHCHERBATKO, AD
   WETSEL, WC
   NEGROVILAR, A
   ARMSTRONG, DL
AF SHCHERBATKO, AD
   WETSEL, WC
   NEGROVILAR, A
   ARMSTRONG, DL
TI CA2+ CHANNEL DIVERSITY IN IMMORTALIZED HYPOTHALAMIC NEURONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
   NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,RES TRIANGLE PK,NC 27709.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A398
EP A398
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002288
ER

PT J
AU SHERMAN, A
   STANLEY, E
AF SHERMAN, A
   STANLEY, E
TI A MODEL OF STEADY-STATE CALCIUM IV RELATIONS IN NONIDEAL CELL STRUCTURES
   - CABLES AND SHEETS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
   NINCDS,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A247
EP A247
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001420
ER

PT J
AU SMITH, CJ
   SHIBATA, H
   MANGANIELLO, V
   BELFRAGE, P
   KONO, T
AF SMITH, CJ
   SHIBATA, H
   MANGANIELLO, V
   BELFRAGE, P
   KONO, T
TI PHOSPHORYLATION AND ACTIVATION OF HORMONE-SENSITIVE CAMP
   PHOSPHODIESTERASE (CGI PDE) BY CYTOSOLIC EXTRACTS OF INSULIN-TREATED RAT
   ADIPOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   UNIV LUND,DEPT MED PHYSIOL CHEM,S-22101 LUND,SWEDEN.
   VANDERBILT UNIV,MED CTR,SCH MED,DEPT MOLEC PHYSIOL & BIOPHYS,NASHVILLE,TN 37232.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A340
EP A340
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001949
ER

PT J
AU SMOLEN, P
   EHRENSTEIN, G
AF SMOLEN, P
   EHRENSTEIN, G
TI INFLUENCE OF INJECTION VOLUME ON THE THRESHOLD AMOUNT OF INOSITOL
   TRISPHOSPHATE (IP3) REQUIRED FOR EGG ACTIVATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,MATH RES BRANCH,BETHESDA,MD 20892.
   NINCDS,BIOPHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A508
EP A508
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002921
ER

PT J
AU STEINBACH, PJ
   LONCHARICH, RJ
   BROOKS, BR
AF STEINBACH, PJ
   LONCHARICH, RJ
   BROOKS, BR
TI ENVIRONMENTAL AND SOLVATION EFFECTS ON PROTEIN DYNAMICS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,DIV COMP RES & TECHNOL,MOLEC GRAPH & SIMULAT LAB,BETHESDA,MD 20892.
   ELI LILLY & CO,LILLY RES LAB,SUPERCOMP APPLICAT & MOLEC DESIGN,INDIANAPOLIS,IN 46285.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A462
EP A462
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002651
ER

PT J
AU STEVEN, AC
   BOOY, FP
   GREENSTONE, HL
   TRUS, BL
   NEWCOMB, WW
   BROWN, JC
AF STEVEN, AC
   BOOY, FP
   GREENSTONE, HL
   TRUS, BL
   NEWCOMB, WW
   BROWN, JC
TI DNA-PHAGE ASSEMBLY AS A MODEL FOR HERPESVIRUS CAPSID ASSEMBLY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS,STRUCT BIOL RES LAB,BETHESDA,MD 20892.
   NIH,DCRT,COMP SYST LAB,BETHESDA,MD 20892.
   UNIV VIRGINIA,HLTH SCI CTR,DEPT MICROBIOL,CHARLOTTESVILLE,VA 22908.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A136
EP A136
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000785
ER

PT J
AU SZWEDA, LI
   STADTMAN, ER
AF SZWEDA, LI
   STADTMAN, ER
TI THE ROLE OF METAL CHELATORS IN IRON-CATALYZED INACTIVATION OF
   GLUCOSE-6-PHOSPHATE-DEHYDROGENASE FROM LEUCONOSTOC-MESENTEROIDES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A182
EP A182
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001041
ER

PT J
AU TEKLE, E
   ASTUMIAN, RD
   CHOCK, PB
AF TEKLE, E
   ASTUMIAN, RD
   CHOCK, PB
TI THE ROLE OF IONIC-STRENGTH ON THE RESEALING RATE OF MEMBRANE
   ELECTROPORES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
   NATL INST STAND & TECHNOL,DIV BIOTECHNOL,GAITHERSBURG,MD 20899.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A172
EP A172
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000982
ER

PT J
AU UCHIDA, K
   STADTMAN, ER
AF UCHIDA, K
   STADTMAN, ER
TI 4-HYDROXYNONENAL-HISTIDINE ADDUCTS GENERATED IN LIPOPROTEINS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A371
EP A371
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002124
ER

PT J
AU VANDEGRIFF, KD
   LETELLIER, YC
   HESS, JR
   SHRAGER, RI
AF VANDEGRIFF, KD
   LETELLIER, YC
   HESS, JR
   SHRAGER, RI
TI EVALUATION OF METHEMOGLOBIN FORMATION AND QUATERNARY TRANSITION DURING
   MEASUREMENTS OF OXYGEN EQUILIBRIUM BINDING TO HUMAN HEMOGLOBIN BY
   RAPID-SCANNING SPECTROPHOTOMETRY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 LETTERMAN ARMY INST RES,SAN FRANCISCO,CA 94129.
   NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A55
EP A55
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000312
ER

PT J
AU VANOSDOL, W
   FUJIMORI, K
   WEINSTEIN, JN
AF VANOSDOL, W
   FUJIMORI, K
   WEINSTEIN, JN
TI MONOCLONAL-ANTIBODY DISTRIBUTION IN MICROSCOPIC TUMOR NODULES -
   CONSEQUENCES OF A BINDING-SITE BARRIER
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,MATH BIOL LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A42
EP A42
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000240
ER

PT J
AU VENTURA, C
   CAPOGROSSI, MC
   SPURGEON, HA
   LAKATTA, EG
AF VENTURA, C
   CAPOGROSSI, MC
   SPURGEON, HA
   LAKATTA, EG
TI RAPID ALKALINE OSCILLATIONS IN CYTOSOLIC PH TRIGGER
   SARCOPLASMIC-RETICULUM (SR) CA2+ RELEASE AND LARGE PHASIC CONTRACTIONS
   FOLLOWING SR CA2+ DEPLETION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A26
EP A26
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000143
ER

PT J
AU WANG, F
   SELLERS, JR
AF WANG, F
   SELLERS, JR
TI REGULATION OF ACTIN FILAMENT SLIDING BY MYOSIN PHOSPHORYLATION AND
   TROPONIN USING LIMULUS CONTRACTILE PROTEIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A439
EP A439
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002518
ER

PT J
AU WEISSINGER, EM
   MISCHAK, H
   LARGAESPADA, DA
   KAEHLER, DA
   MITCHELL, T
   GOODNIGHT, J
   SMITHGILL, S
   RISSER, R
   MUSHINSKI, JF
AF WEISSINGER, EM
   MISCHAK, H
   LARGAESPADA, DA
   KAEHLER, DA
   MITCHELL, T
   GOODNIGHT, J
   SMITHGILL, S
   RISSER, R
   MUSHINSKI, JF
TI INDUCTION OF PLASMACYTOMAS SECRETING ANTIGEN-SPECIFIC
   MONOCLONAL-ANTIBODIES WITH A RETROVIRUS COEXPRESSING V-ABL AND C-MYC
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   UNIV WISCONSIN,MADISON,WI 53706.
RI Mischak, Harald/E-8685-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A43
EP A43
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000242
ER

PT J
AU WELCH, RW
   RUDOLPH, FB
AF WELCH, RW
   RUDOLPH, FB
TI CHARACTERIZATION OF AN NADH DEPENDENT BUTANOL DEHYDROGENASE ISOZYME FROM
   CLOSTRIDIUM-ACETOBUTYLICUM ATCC-824
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
   RICE UNIV,HOUSTON,TX 77251.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A461
EP A461
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002646
ER

PT J
AU WHITE, RE
   ARMSTRONG, DL
AF WHITE, RE
   ARMSTRONG, DL
TI AN ENZYMATIC MECHANISM FOR K+ CHANNEL STIMULATION BY NEUROPEPTIDES THAT
   ACTIVATE PERTUSSIS TOXIN SENSITIVE G-PROTEINS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A382
EP A382
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002191
ER

PT J
AU WIDEN, SG
   WILSON, SH
AF WIDEN, SG
   WILSON, SH
TI REGULATORY ELEMENTS IN THE HUMAN DNA-POLYMERASE (BETA-POL) PROMOTER
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A483
EP A483
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002775
ER

PT J
AU WILLIAMSON, CK
   KNUTTEL, A
   KNUTSON, JR
AF WILLIAMSON, CK
   KNUTTEL, A
   KNUTSON, JR
TI A SIMPLE INTERNALLY MIXED PHOTOMULTIPLIER WITH GHZ RESPONSE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,CELL BIOL LAB,BETHESDA,MD 20892.
   NHLBI,CARDIAC ENERGET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A312
EP A312
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001787
ER

PT J
AU WILSON, SH
   KUMAR, A
   BECERRA, P
   LEE, BJ
   HATFIELD, D
AF WILSON, SH
   KUMAR, A
   BECERRA, P
   LEE, BJ
   HATFIELD, D
TI ISOLATION AND CHARACTERIZATION OF POLYNUCLEOTIDE BINDING REGIONS OF
   RECOMBINANT HIV-1 REVERSE-TRANSCRIPTASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM & EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A281
EP A281
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001608
ER

PT J
AU WOLFF, EC
   JAKUS, J
   PARK, MH
   FOLK, JE
AF WOLFF, EC
   JAKUS, J
   PARK, MH
   FOLK, JE
TI INHIBITORS OF DEOXYHYPUSINE SYNTHASE AS POTENTIAL REGULATORS OF HYPUSINE
   BIOSYNTHESIS IN EIF-5A
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A39
EP A39
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000218
ER

PT J
AU WU, C
   CLOS, J
   GIORGI, G
   RABINDRAN, S
   WESTWOOD, JT
AF WU, C
   CLOS, J
   GIORGI, G
   RABINDRAN, S
   WESTWOOD, JT
TI INDUCTION OF THE HEAT-SHOCK RESPONSE IN HIGHER EUKARYOTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A273
EP A273
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001568
ER

PT J
AU XU, SG
   BRENNER, B
   CHALOVICH, JM
   YU, LC
AF XU, SG
   BRENNER, B
   CHALOVICH, JM
   YU, LC
TI RADIAL ELASTICITY OF WEAKLY ATTACHED CROSSBRIDGES IN RELAXED MUSCLE - A
   FURTHER EVIDENCE THAT RADIAL ELASTICITY OF ATTACHED CROSSBRIDGES IS
   STATE-DEPENDENT
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
   UNIV ULM,W-7900 ULM,GERMANY.
   E CAROLINA UNIV,GREENVILLE,NC 27834.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A292
EP A292
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001664
ER

PT J
AU YAMADA, KM
   AOTA, S
   LAFLAMME, SE
   AKIYAMA, SK
AF YAMADA, KM
   AOTA, S
   LAFLAMME, SE
   AKIYAMA, SK
TI MATRIX MOLECULES AND RECEPTORS IN CELL-ADHESION AND MIGRATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,DEV BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A412
EP A412
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002367
ER

PT J
AU YANG, XJ
   MILES, EW
AF YANG, XJ
   MILES, EW
TI THREONINE-183 AND ADJACENT FLEXIBLE LOOP RESIDUES IN THE ALPHA-SUBUNIT
   OF TRYPTOPHAN SYNTHASE HAVE CRITICAL ROLES IN MODULATING THE
   ENZYMATIC-ACTIVITIES OF THE BETA-SUBUNIT IN THE ALPHA-2-BETA-2 COMPLEX
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A458
EP A458
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002624
ER

PT J
AU YIM, MB
   KWAK, HS
   CHOCK, PB
   STADTMAN, ER
AF YIM, MB
   KWAK, HS
   CHOCK, PB
   STADTMAN, ER
TI PRODUCTION OF FREE-RADICALS CATALYZED BY CU,ZN-SUPEROXIDE DISMUTASE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A182
EP A182
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001039
ER

PT J
AU YOO, SH
   LEWIS, MS
AF YOO, SH
   LEWIS, MS
TI EFFECTS OF PH AND CA2+ ON MONOMER-DIMER AND MONOMERTETRAMER EQUILIBRIA
   OF CHROMOGRANIN-A
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,NCRR,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892.
   NIDCD,CELLULAR BIOL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A473
EP A473
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002717
ER

PT J
AU YOUNG, L
   COVELL, DG
   JERNIGAN, RL
AF YOUNG, L
   COVELL, DG
   JERNIGAN, RL
TI DETECTION OF SURFACE TARGETS ON ENZYME AND INHIBITOR MOLECULES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,PRI,ASCL,BETHESDA,MD 21702.
RI Jernigan, Robert/A-5421-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A199
EP A199
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001139
ER

PT J
AU ZHOU, HX
   SZABO, A
AF ZHOU, HX
   SZABO, A
TI STOCHASTICALLY GATED LIGAND-BINDING
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A144
EP A144
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000825
ER

PT J
AU ZHURKIN, VB
   RAGHUNATHAN, G
   CAMERINIOTERO, RD
   JERNIGAN, RL
AF ZHURKIN, VB
   RAGHUNATHAN, G
   CAMERINIOTERO, RD
   JERNIGAN, RL
TI R-FORM DNA - TRIPLE HELIX MEDIATED BY RECOMBINATION PROTEIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,MATH BIOL LAB,BETHESDA,MD 20892.
   NIDDK,GENET & BIOCHEM BRANCH,BETHESDA,MD 20892.
RI Jernigan, Robert/A-5421-2012
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A482
EP A482
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002766
ER

PT J
AU ZIMMERBERG, J
AF ZIMMERBERG, J
TI DIFFERENT HYDRATION OF FUNCTIONALLY DISTINCT PROTEIN CONFORMATIONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,THEORET & PHYS BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A278
EP A278
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44001591
ER

PT J
AU ZIMMERMAN, SB
   TRACH, SO
AF ZIMMERMAN, SB
   TRACH, SO
TI MACROMOLECULE CONCENTRATIONS AND EXCLUDED VOLUME EFFECTS IN THE
   CYTOPLASM OF ESCHERICHIA-COLI
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A363
EP A363
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44002082
ER

PT J
AU ZOLKIEWSKI, M
   GINSBURG, A
AF ZOLKIEWSKI, M
   GINSBURG, A
TI THERMALLY INDUCED, REVERSIBLE PARTIAL UNFOLDING OF DODECAMERIC
   GLUTAMINE-SYNTHETASE (GS) FROM ESCHERICHIA-COLI
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JAN 1
PY 1992
VL 6
IS 1
BP A61
EP A61
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GY440
UT WOS:A1992GY44000348
ER

PT J
AU NELSON, LM
   KIMZEY, LM
   WHITE, BJ
   MERRIAM, GR
AF NELSON, LM
   KIMZEY, LM
   WHITE, BJ
   MERRIAM, GR
TI GONADOTROPIN SUPPRESSION FOR THE TREATMENT OF KARYOTYPICALLY NORMAL
   SPONTANEOUS PREMATURE OVARIAN FAILURE - A CONTROLLED TRIAL
SO FERTILITY AND STERILITY
LA English
DT Review
DE HYPERGONADOTROPIC AMENORRHEA; PREMATURE OVARIAN FAILURE
ID AUTOIMMUNE OOPHORITIS; SPONTANEOUS PREGNANCY; MENOPAUSE; SECRETION;
   HORMONE; DISEASE; WOMEN
AB Objective: To determine if gonadotropin suppression improves ovarian follicle function or ovulation rates in patients with karyotypically normal spontaneous premature ovarian failure.
   Design: Prospective, double-blind, placebo-controlled, crossover trial.
   Setting: Tertiary care research institution.
   Interventions: Two intervention phases lasting 4 months each: one placebo phase, and one treatment phase during which each patient received daily subcutaneous injections of 300-mu-g of the gonadotropin-releasing hormone agonist (GnRH-a) deslorelin. During both phases, patients took a standardized estrogen (E) replacement regimen.
   Patients, Participants: Twenty-six patients with karyotypically normal spontaneous premature ovarian failure ranging in age from 18 to 39 years.
   Main Outcome Measures: We measured serum estradiol (E2) and progesterone (P) levels weekly during the 2 months after each intervention. We defined a serum E2 > 50 pg/mL (184 pmol/L) as evidence for ovarian follicle function and a serum P > 3.0 ng/mL (9.5 nmol/L) as evidence for ovulation.
   Results: The GnRH-a therapy did not significantly enhance recovery of ovarian follicle function or the chance of ovulation. The power to detect a 40% and a 33% ovulation success rate with therapy was 0.95 and 0.83, respectively. We found evidence for ovarian follicle function in 11 of 23 women (48%), and 4 women (17%) ovulated.
   Conclusions: Patients with karyotypically normal spontaneous premature ovarian failure treated with E replacement did not benefit from the additional gonadotropin suppression achieved with GnRH-a. Because these patients have a significant possibility of spontaneous remission, attempts to induce ovulation should be limited to controlled trials designed to determine safety and effectiveness.
C1 NIH,CTR RADIOL,DEPT NURSING,BETHESDA,MD 20892.
   NIDDKD,CHEM BIOL LAB,BETHESDA,MD.
RP NELSON, LM (reprint author), NICHHD,DEV ENDOCRINOL BRANCH,BLDG 10,ROOM 10N262,BETHESDA,MD 20892, USA.
NR 25
TC 51
Z9 55
U1 0
U2 2
PU AMER SOC REPRODUCTIVE MEDICINE
PI BIRMINGHAM
PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD JAN
PY 1992
VL 57
IS 1
BP 50
EP 55
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA GY267
UT WOS:A1992GY26700009
PM 1730330
ER

PT J
AU BOINSKI, S
AF BOINSKI, S
TI OLFACTORY COMMUNICATION AMONG COSTA-RICAN SQUIRREL-MONKEYS - A
   FIELD-STUDY
SO FOLIA PRIMATOLOGICA
LA English
DT Review
DE COMMUNICATION, OLFACTORY; SQUIRREL MONKEY; SAIMIRI; URINE WASHING;
   REPRODUCTIVE SYNCHRONY; FIELD STUDY; GENITAL INSPECTION
ID SAIMIRI-OERSTEDI; BEHAVIOR; SCIUREUS; PATTERNS; HABITAT; FOREST
AB Behaviors with a possible role in olfactory communication among troop members were investigated as part of a field study on the reproductive and foraging ecology of squirrel monkeys (Saimiri oerstedi) in Costa Rica. All age classes engaged in the olfaction-related behaviors. Apart from olfactory investigation of female genitals by males during the mating season, no other potential olfaction-related behavior (urine wash, branch investigation, rump, chest, back rub and sneeze) exceeded 1 % of mean behavioral samples. Assessment of reproduction condition appears to be the primary function of such olfactory investigation of the female genital region. The primary function of urine washing is suggested to be the general communication of reproductive status, possibly facilitating reproductive synchrony. Sneezing, rump, back and chest rubbing do not appear to deposit substances active in olfactory communication.
C1 NICHHD,CTR ANIM,COMPARAT ETHOL LAB,POOLESVILLE,MD.
NR 52
TC 24
Z9 24
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0015-5713
J9 FOLIA PRIMATOL
JI Folia Primatol.
PY 1992
VL 59
IS 3
BP 127
EP 136
DI 10.1159/000156650
PG 10
WC Zoology
SC Zoology
GA LB908
UT WOS:A1992LB90800002
PM 1306175
ER

PT J
AU RESZKA, K
   BILSKI, P
   CHIGNELL, CF
AF RESZKA, K
   BILSKI, P
   CHIGNELL, CF
TI EPR-SPECTRA OF DMPO SPIN ADDUCTS OF SUPEROXIDE AND HYDROXYL RADICALS IN
   PYRIDINE
SO FREE RADICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE EPR; DMPO; SUPEROXIDE; HYDROXYL RADICAL; PYRIDINE
ID HYDROGEN-PEROXIDE; PHOTOLYSIS; GENERATION; ION
AB Electron spin resonance spectroscopy and the spin trapping technique were used to study the formation of the superoxide radical in pyridine. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was employed as a trapping agent. Superoxide radical was generated using chemical (potassium superoxide) and photochemical methods with anthralin, benzanthrone, rose bengal, 1,8-dihydroxyanthraquinone and zinc tetraphenylporphyrine as photoactive pigments. Hyperfine coupling (hf) constants for DMPO/O2.- were determined to be a(N) = 12.36 G, a(H)beta = 9.85 G, a(H)gamma = 1.34 G. The a(N) and a(H)beta hf constants are in good agreement with values calculated from a previously determined relationship between hf constants and solvent acceptor number (Reszka et al., (1992) Free Radical Res. Commun., in press). When concentrated hydrogen peroxide was added to DMPO in pyridine a similar EPR spectrum was observed. It is suggested that in this case the DMPO/.O2H adduct is formed by nucleophilic addition of H2O2 to DMPO to give a hydroxylamine, followed by oxidation to the respective nitroxide. The EPR spectrum observed when tetrapropylammonium hydroxide and H2O2 were added to DMPO in pyridine had hf couplings a(N) = 13.53 G, a(H)beta = 11.38 G, a(H)gamma = 0.79 G and it was assigned to a DM PO/'OH adduct. This assignment was based on similarity of this spectrum to the one produced by UV photolysis of hydrogen peroxide and DMPO in aqueous solution and subsequent transfer to pyridine.
RP RESZKA, K (reprint author), NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709, USA.
NR 20
TC 12
Z9 12
U1 5
U2 15
PU HARWOOD ACAD PUBL GMBH
PI READING
PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL
SN 8755-0199
J9 FREE RADICAL RES COM
JI Free Radic. Res. Commun.
PY 1992
VL 17
IS 6
BP 377
EP 385
DI 10.3109/10715769209083142
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA KH064
UT WOS:A1992KH06400003
PM 1337536
ER

PT J
AU KELMAN, DJ
   MASON, RP
AF KELMAN, DJ
   MASON, RP
TI THE MYOGLOBIN-DERIVED RADICAL FORMED ON REACTION OF METMYOGLOBIN WITH
   HYDROGEN-PEROXIDE IS NOT A TYROSINE PEROXYL RADICAL
SO FREE RADICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE EPR; METMYOGLOBIN; SPIN TRAPPING; PEROXYL RADICAL; HYDROGEN PEROXIDE
ID ELECTRON-SPIN RESONANCE; SPERM WHALE; SYSTEMS; TYR-151
RP KELMAN, DJ (reprint author), NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709, USA.
NR 20
TC 36
Z9 36
U1 0
U2 1
PU HARWOOD ACAD PUBL GMBH
PI READING
PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL
SN 8755-0199
J9 FREE RADICAL RES COM
JI Free Radic. Res. Commun.
PY 1992
VL 16
IS 1
BP 27
EP 33
DI 10.3109/10715769209049156
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA HG698
UT WOS:A1992HG69800004
PM 1325397
ER

PT J
AU IWAHASHI, H
   PARKER, CE
   TOMER, KB
   MASON, RP
AF IWAHASHI, H
   PARKER, CE
   TOMER, KB
   MASON, RP
TI DETECTION OF THE ETHYL-RADICAL AND PENTYL-RADICAL ADDUCTS OF
   ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE IN RAT-LIVER MICROSOMES
   TREATED WITH ADP, NADPH AND FERRIC-CHLORIDE
SO FREE RADICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE ETHYL RADICAL; PENTYL RADICAL; SPIN TRAPPING; MICROSOMAL OXIDATION;
   HPLC-EPR
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; CARBON-TETRACHLORIDE METABOLISM;
   ELECTRON-SPIN RESONANCE; LIPID-PEROXIDATION; INVIVO; INVITRO; ACID;
   IDENTIFICATION; SPECTROMETRY; SEPARATION
C1 NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709.
RI Tomer, Kenneth/E-8018-2013
NR 34
TC 19
Z9 19
U1 0
U2 0
PU HARWOOD ACAD PUBL GMBH
PI READING
PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL
SN 8755-0199
J9 FREE RADICAL RES COM
JI Free Radic. Res. Commun.
PY 1992
VL 16
IS 5
BP 295
EP 301
DI 10.3109/10715769209049182
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JC987
UT WOS:A1992JC98700003
PM 1324207
ER

PT B
AU YOUNG, WS
AF YOUNG, WS
BE CHADWICK, DJ
   MARSH, J
TI REGULATION OF GENE-EXPRESSION IN THE HYPOTHALAMUS - HYBRIDIZATION
   HISTOCHEMICAL-STUDIES
SO FUNCTIONAL ANATOMY OF THE NEUROENDOCRINE HYPOTHALAMUS
SE CIBA FOUNDATION SYMPOSIA
LA English
DT Proceedings Paper
CT SYMP ON FUNCTIONAL ANATOMY OF THE NEUROENDOCRINE HYPOTHALAMUS
CY OCT 08-10, 1991
CL BUDAPEST, HUNGARY
SP CIBA FDN, ACAD SCI HUNGARY
RP YOUNG, WS (reprint author), NATL INST MENT HLTH,CELL BIOL LAB,BETHESDA,MD 20892, USA.
RI Young, W Scott/A-9333-2009
OI Young, W Scott/0000-0001-6614-5112
NR 0
TC 9
Z9 10
U1 0
U2 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA CHICHESTER
BN 0-471-93440-2
J9 CIBA F SYMP
PY 1992
VL 168
BP 127
EP 143
PG 17
WC Anatomy & Morphology; Endocrinology & Metabolism; Neurosciences
SC Anatomy & Morphology; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA BW26B
UT WOS:A1992BW26B00008
PM 1425021
ER

PT J
AU DIETZ, DD
   ELWELL, MR
   CHAPIN, RE
   SHELBY, MD
   THOMPSON, MB
   FILLER, R
   STEDHAM, MA
AF DIETZ, DD
   ELWELL, MR
   CHAPIN, RE
   SHELBY, MD
   THOMPSON, MB
   FILLER, R
   STEDHAM, MA
TI SUBCHRONIC (13-WEEK) TOXICITY STUDIES OF ORAL PHENOLPHTHALEIN IN FISCHER
   344 RATS AND B6C3F1 MICE
SO FUNDAMENTAL AND APPLIED TOXICOLOGY
LA English
DT Article
ID PERIPHERAL-BLOOD; LAXATIVE ACTION; TRANSPORT; ABUSE; ERYTHROCYTES;
   MICRONUCLEI; INDUCTION; MECHANISM; INVITRO
C1 NIEHS,NATL TOXICOL PROGRAM,DIV TOXICOL RES & TESTING,RES TRIANGLE PK,NC 27709.
   MICROBIOL ASSOCIATES INC,BETHESDA,MD 20816.
OI Chapin, Robert/0000-0002-5997-1261
FU NIEHS NIH HHS [Y01-ES-40113]
NR 55
TC 11
Z9 11
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0272-0590
J9 FUND APPL TOXICOL
JI Fundam. Appl. Toxicol.
PD JAN
PY 1992
VL 18
IS 1
BP 48
EP 58
DI 10.1016/0272-0590(92)90194-M
PG 11
WC Toxicology
SC Toxicology
GA HB794
UT WOS:A1992HB79400006
PM 1601209
ER

PT B
AU MONTPIED, P
   PAUL, SM
AF MONTPIED, P
   PAUL, SM
BE BIGGIO, G
   CONCAS, A
   COSTA, E
TI STUDIES ON THE EXPRESSION OF GABA(A) RECEPTOR ALPHA-SUBUNIT
   MESSENGER-RNAS
SO GABAERGIC SYNAPTIC TRANSMISSION: MOLECULAR, PHARMACOLOGICAL, AND
   CLINICAL ASPECTS
SE ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY
LA English
DT Review
CT 7TH SARDINIAN CONF ON NEUROSCIENCE
CY JUN, 1991
CL CAGLIARI, ITALY
SP FIDIA RES LABS ABANO TERME, CNR
ID DOWN-REGULATION; RAT; COMPLEX; BRAIN
RP MONTPIED, P (reprint author), NIMH,CLIN NEUROSCI BRANCH,MOLEC PHARMACOL SECT,BLDG 10,ROOM 4N214,BETHESDA,MD 20892, USA.
NR 0
TC 7
Z9 7
U1 0
U2 0
PU RAVEN PRESS
PI NEW YORK
PA NEW YORK
BN 0-88167-923-2
J9 ADV BIOCHEM PSYCHOPH
PY 1992
VL 47
BP 301
EP 309
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Pharmacology &
   Pharmacy; Physiology
SC Biochemistry & Molecular Biology; Neurosciences & Neurology;
   Pharmacology & Pharmacy; Physiology
GA BV92C
UT WOS:A1992BV92C00032
PM 1324580
ER

PT B
AU WEIGHT, FF
   AGUAYO, LG
   WHITE, G
   LOVINGER, DM
   PEOPLES, RW
AF WEIGHT, FF
   AGUAYO, LG
   WHITE, G
   LOVINGER, DM
   PEOPLES, RW
BE BIGGIO, G
   CONCAS, A
   COSTA, E
TI GABA-GATED AND GLUTAMATE-GATED ION CHANNELS AS MOLECULAR SITES OF
   ALCOHOL AND ANESTHETIC ACTION
SO GABAERGIC SYNAPTIC TRANSMISSION: MOLECULAR, PHARMACOLOGICAL, AND
   CLINICAL ASPECTS
SE ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY
LA English
DT Review
CT 7TH SARDINIAN CONF ON NEUROSCIENCE
CY JUN, 1991
CL CAGLIARI, ITALY
SP FIDIA RES LABS ABANO TERME, CNR
ID ETHANOL INHIBITION; RAT; HIPPOCAMPAL; RELEASE; RECEPTORS; NEURONS;
   SLICES; CELLS; BRAIN
RP WEIGHT, FF (reprint author), NIAAA,MOLEC & CELLULAR NEUROBIOL LAB,12501 WASHINGTON AVE,ROCKVILLE,MD 20852, USA.
NR 0
TC 59
Z9 60
U1 1
U2 6
PU RAVEN PRESS
PI NEW YORK
PA NEW YORK
BN 0-88167-923-2
J9 ADV BIOCHEM PSYCHOPH
PY 1992
VL 47
BP 335
EP 347
PG 13
WC Biochemistry & Molecular Biology; Neurosciences; Pharmacology &
   Pharmacy; Physiology
SC Biochemistry & Molecular Biology; Neurosciences & Neurology;
   Pharmacology & Pharmacy; Physiology
GA BV92C
UT WOS:A1992BV92C00036
PM 1354918
ER

PT J
AU EMANUEL, A
   SZUCS, S
   WEIER, HUG
   KOVACS, G
AF EMANUEL, A
   SZUCS, S
   WEIER, HUG
   KOVACS, G
TI CLONAL ABERRATIONS OF CHROMOSOMES-X, CHROMOSOME-Y, CHROMOSOME-7 AND
   CHROMOSOME-10 IN NORMAL KIDNEY TISSUE OF PATIENTS WITH RENAL-CELL TUMORS
SO GENES CHROMOSOMES & CANCER
LA English
DT Note
ID CARCINOMA; CYTOGENETICS; TRISOMY-7
AB By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7- and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo.
C1 UNIV FREIBURG,INST PATHOL,CYTOGENET LAB,W-7800 FREIBURG,GERMANY.
   UNIV CALIF LAWRENCE LIVERMORE NATL LAB,DIV BIOMED SCI,LIVERMORE,CA 94550.
   NCI,FREDERICK CANC RES & DEV CTR,DYNCORP,PROGRAM RESOURCES INC,FREDERICK,MD 21701.
FU NCI NIH HHS [N01-CO-74102]
NR 18
TC 62
Z9 62
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 1045-2257
J9 GENE CHROMOSOME CANC
JI Gene Chromosomes Cancer
PD JAN
PY 1992
VL 4
IS 1
BP 75
EP 77
DI 10.1002/gcc.2870040110
PG 3
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA HC349
UT WOS:A1992HC34900009
PM 1377012
ER

PT J
AU VARESCO, L
   CALIGO, MA
   SIMI, P
   BLACK, DM
   NARDINI, V
   CASARINO, L
   ROCCHI, M
   FERRARA, G
   SOLOMON, E
   BEVILACQUA, G
AF VARESCO, L
   CALIGO, MA
   SIMI, P
   BLACK, DM
   NARDINI, V
   CASARINO, L
   ROCCHI, M
   FERRARA, G
   SOLOMON, E
   BEVILACQUA, G
TI THE NM23-GENE MAPS TO HUMAN-CHROMOSOME BAND-17Q22 AND SHOWS A
   RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM WITH BGLII
SO GENES CHROMOSOMES & CANCER
LA English
DT Note
ID NUCLEOSIDE DIPHOSPHATE KINASE; TUMOR-METASTASIS; DROSOPHILA DEVELOPMENT;
   NM23; GENE; CARCINOMA; PROTEIN; CANCER
AB The NM23-H1 gene is a putative tumor suppressor gene that may be important in the metastasic process. Recent genetic and immunological dam indicate that the NM23-H1 gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23-H1 by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with Bg/II was demonstrated.
C1 UNITA SANITARIA LOCALE 12,CYTOGENET LAB,PISA,ITALY.
   UNIV PISA,INST PATHOL ANAT & HISTOL,I-56100 PISA,ITALY.
   IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND.
   INST G GASLINI,GENOA,ITALY.
   NATL CANC INST,IST SCI TUMORI,GENOA,ITALY.
NR 19
TC 57
Z9 59
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 1045-2257
J9 GENE CHROMOSOME CANC
JI Gene Chromosomes Cancer
PD JAN
PY 1992
VL 4
IS 1
BP 84
EP 88
DI 10.1002/gcc.2870040113
PG 5
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA HC349
UT WOS:A1992HC34900012
PM 1377015
ER

PT J
AU GOLDIN, LR
AF GOLDIN, LR
TI DETECTION OF LINKAGE UNDER HETEROGENEITY - COMPARISON OF THE 2-LOCUS VS
   ADMIXTURE MODELS
SO GENETIC EPIDEMIOLOGY
LA English
DT Article
DE GENETIC HETEROGENEITY; COMMON DISEASES; ADMIXTURE TEST; 2-LOCUS MODEL
ID POWER
AB Linkage analysis under the two-locus model and the admixture model was compared on pedigree data for a common disease simulated under a model of genetic heterogeneity. The ascertainment of families was designed so that the samples had a large proportion of families segregating for both disease loci. The two-locus linkage analysis model did not demonstrate increased power of detecting linkage or more accurate estimates of the recombination fraction, 0 than did the admixture model linkage analysis. When a sample was purposely chosen so that all of the families were segregating for both loci, then the two-locus lod score analysis was better. However, the increased power depended on assuming the correct gene frequency for the linked locus. It can be concluded that under the conditions of genetic heterogeneity examined here, testing for linkage under the admixture model is the preferred method of analysis. However, this is not a general conclusion that can apply to all two-locus disease models.
RP GOLDIN, LR (reprint author), NIMH,CLIN NEUROGENET BRANCH,BLDG 10,ROOM 3N218,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 9
TC 40
Z9 40
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0741-0395
J9 GENET EPIDEMIOL
JI Genet. Epidemiol.
PY 1992
VL 9
IS 1
BP 61
EP 66
DI 10.1002/gepi.1370090107
PG 6
WC Genetics & Heredity; Mathematical & Computational Biology
SC Genetics & Heredity; Mathematical & Computational Biology
GA HY394
UT WOS:A1992HY39400006
PM 1634107
ER

PT J
AU LIGHTFOOT, DA
   BARON, AJ
   COCK, JM
   WOOTTON, JC
AF LIGHTFOOT, DA
   BARON, AJ
   COCK, JM
   WOOTTON, JC
TI A NITRATE REDUCTASE GENE OF THE CYANOBACTERIUM SYNECHOCOCCUS PCC6301
   INFERRED BY HETEROLOGOUS HYBRIDIZATION, CLONING AND TARGETED MUTAGENESIS
SO GENETICA
LA English
DT Article
ID ESCHERICHIA-COLI; ANACYSTIS-NIDULANS; NAR OPERON; NUCLEOTIDE-SEQUENCE;
   SUBUNIT; REGION; DNA; PURIFICATION; STRAIN; TRANSFORMATION
AB DNA probes from the narG gene of Escherichia coli, which encodes the large polypeptide of respiratory nitrate reductase, show cross-hybridization at low stringency to a single region of the genome of the cyanobacterium Synechococcus PCC6301. This segment of cyanobacterial DNA was cloned as the insert of plasmid pDN1 and characterized. RNA complementary to pDN1 was shown to be substantially more abundant in nitrate grown cells of Synechococcus PCC6301 than in ammonium grown cells, thus parallelling the nitrate induction and ammonium repression of nitrate reductase activity in cultures of this cyanobacterium. A mutant of Synechococcus PCC6301 deficient in nitrate reductase activity was obtained after a potentially mutagenic transformation treatment using pDN1 as a donor. This mutant was restored to the wild type phenotype following stable integrative transformation with pDN1 DNA. Taken together these data suggest that pDN1 might encode a polypeptide of nitrate reductase. pDN1 is distinct from three clones of genes involved in nitrate assimilation that were isolated previously from the related cyanobacterium Synechococcus PCC7942 (Kuhlemeier et al., 1984a, J.Bact. 159, 36-41, and 1984b, Gene 31, 109-116).
C1 UNIV SO ILLINOIS,DEPT PLANT & SOIL SCI,CARBONDALE,IL 62901.
   INRA,CNRS,BIOL MOLEC RELAT PLANTES MICROORGANISMES LAB,F-31326 CASTANET TOLOSAN,FRANCE.
   NIH,NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894.
RP LIGHTFOOT, DA (reprint author), UNIV LEEDS,DEPT GENET,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND.
OI Lightfoot, David/0000-0002-5725-4381
NR 42
TC 0
Z9 0
U1 0
U2 0
PU KLUWER ACADEMIC PUBL
PI DORDRECHT
PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 0016-6707
J9 GENETICA
JI Genetica
PY 1992
VL 85
IS 2
BP 107
EP 117
DI 10.1007/BF00120317
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA JA104
UT WOS:A1992JA10400001
PM 1378036
ER

PT J
AU TORRONI, A
   SCHURR, TG
   YANG, CC
   SZATHMARY, EJE
   WILLIAMS, RC
   SCHANFIELD, MS
   TROUP, GA
   KNOWLER, WC
   LAWRENCE, DN
   WEISS, KM
   WALLACE, DC
AF TORRONI, A
   SCHURR, TG
   YANG, CC
   SZATHMARY, EJE
   WILLIAMS, RC
   SCHANFIELD, MS
   TROUP, GA
   KNOWLER, WC
   LAWRENCE, DN
   WEISS, KM
   WALLACE, DC
TI NATIVE-AMERICAN MITOCHONDRIAL-DNA ANALYSIS INDICATES THAT THE AMERIND
   AND THE NADENE POPULATIONS WERE FOUNDED BY 2 INDEPENDENT MIGRATIONS
SO GENETICS
LA English
DT Article
ID BASE PAIR RECOGNITION; PAPUA-NEW-GUINEA; PRIVATE POLYMORPHISMS;
   RESTRICTION ENZYMES; LENGTH MUTATIONS; DOGRIB INDIANS; SEQUENCE;
   JAPANESE; PLEISTOCENE; EVOLUTION
AB Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis.  All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants:  HincII site loss at np 13,259, AluI site loss at np 5,176, 9-base pair (9-bp) COII-tRNA(Lys) intergenic deletion and HaeII site grain at np 663.  The HincII np 13,259 and AluI np 5,176 lineages were observed exclusively in Amerinds and were shared by all such tribal groups analyzed, thus demonstrating that North, Central and South American Amerinds originated from a common ancestral genetic stock.  The 9-bp deletion and HaeIII np 663 lineages were found in both the Amerinds and Nadene but the Nadene HaeIII np 663 lineage had a unique sublineage defined by an RsaI site loss at np 16,329.  The amount of sequence variation accumulated in the Amerind HincII np 13,259 and AluI np 5,176 lineages and that in the Amerind portion of the HaeIII np 663 lineage all gave divergence times in the order of 20,000 years before present.  The divergence time for the Nadene portion of the HaeIII np 663 lineage was about 6,000-10,000 years.  Hence, the ancestral Nadene migrated from Asia independently and considerably more recently than the progenitors of the Amerinds.  The divergence times of both the Amerind and Nadene branches of the COII-tRNA(Lys) deletion lineage were intermediate between the Amerind and Nadene specific lineages, raising the possibility of a third source of mtDNA in American Indians.
C1 EMORY UNIV,SCH MED,DEPT BIOCHEM,ATLANTA,GA 30322.
   EMORY UNIV,SCH MED,DEPT ANTHROPOL,ATLANTA,GA 30322.
   UNIV WESTERN ONTARIO,FAC SOCIAL SCI,OFF DEAN,LONDON N6A 5C2,ONTARIO,CANADA.
   ARIZONA STATE UNIV,DEPT ANTHROPOL,TEMPE,AZ 85281.
   ANALYT CENET TESTING CTR INC,DENVER,CO 80231.
   UNIV NEW MEXICO,DEPT PATHOL,ALBUQUERQUE,NM 87131.
   NIDDK,DIABET & ARTHRISTIS EPIDEMIOL SECT,PHOENIX,AZ 85014.
   CTR DIS CONTROL,CTR INFECT DIS,DIV HOST FACTORS,ATLANTA,GA 30333.
   PENN STATE UNIV,DEPT ANTHROPOL,UNIV PK,PA 16802.
   PENN STATE UNIV,GRAD PROGRAM GENET,UNIV PK,PA 16802.
RP TORRONI, A (reprint author), EMORY UNIV,SCH MED,CTR GENET & MOLEC MED,ATLANTA,GA 30322, USA.
RI Torroni, Antonio/E-1557-2011; Schurr, Theodore/A-1336-2007
OI Torroni, Antonio/0000-0002-4163-4478; 
NR 66
TC 356
Z9 366
U1 0
U2 8
PU GENETICS
PI BALTIMORE
PA 428 EAST PRESTON ST, BALTIMORE, MD 21202
SN 0016-6731
J9 GENETICS
JI Genetics
PD JAN
PY 1992
VL 130
IS 1
BP 153
EP 162
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA GX543
UT WOS:A1992GX54300014
PM 1346260
ER

PT J
AU TEMPLETON, NS
   RODGERS, LA
   LEVY, AT
   TING, KL
   KRUTZSCH, HC
   LIOTTA, LA
   STETLERSTEVENSON, WG
AF TEMPLETON, NS
   RODGERS, LA
   LEVY, AT
   TING, KL
   KRUTZSCH, HC
   LIOTTA, LA
   STETLERSTEVENSON, WG
TI CLONING AND CHARACTERIZATION OF A NOVEL HUMAN CDNA THAT HAS DNA
   SIMILARITY TO THE CONSERVED REGION OF THE COLLAGENASE GENE FAMILY
SO GENOMICS
LA English
DT Note
ID NUCLEIC-ACID SEQUENCES; PATTERN-RECOGNITION
C1 NCI,PATHOL LAB,BETHESDA,MD 20892.
   NCI,MATH BIOL LAB,BETHESDA,MD 20892.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 8
TC 13
Z9 14
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0888-7543
J9 GENOMICS
JI Genomics
PD JAN
PY 1992
VL 12
IS 1
BP 175
EP 176
DI 10.1016/0888-7543(92)90425-R
PG 2
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA GV797
UT WOS:A1992GV79700028
PM 1310294
ER

PT B
AU FOZARD, JL
   METTER, EJ
   BRANT, LJ
   PEARSON, JD
   BAKER, GT
AF FOZARD, JL
   METTER, EJ
   BRANT, LJ
   PEARSON, JD
   BAKER, GT
BE BOUMA, H
   GRAAFMANS, JAM
TI PHYSIOLOGY OF AGING
SO GERONTECHNOLOGY
SE STUDIES IN HEALTH TECHNOLOGY AND INFORMATICS
LA English
DT Proceedings Paper
CT 1ST INTERNATIONAL CONGRESS ON GERONTECHNOLOGY
CY AUG, 1991
CL EINDHOVEN, NETHERLANDS
SP EINDHOVEN UNIV TECHNOL, BIOMED & HLTH ORG
RP FOZARD, JL (reprint author), NIA,BALTIMORE,MD 21224, USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU I O S PRESS
PI AMSTERDAM
PA AMSTERDAM
BN 90-5199-072-3
J9 ST HEAL T
PY 1992
VL 3
BP 141
EP 167
PG 27
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA BX03V
UT WOS:A1992BX03V00010
ER

PT B
AU BRANT, LJ
   METTER, EJ
   GORDONSALANT, S
   PEARSON, JD
   FOZARD, JL
AF BRANT, LJ
   METTER, EJ
   GORDONSALANT, S
   PEARSON, JD
   FOZARD, JL
BE BOUMA, H
   GRAAFMANS, JAM
TI MODIFIABLE FACTORS AFFECTING AGE-RELATED HEARING-LOSS
SO GERONTECHNOLOGY
SE STUDIES IN HEALTH TECHNOLOGY AND INFORMATICS
LA English
DT Proceedings Paper
CT 1ST INTERNATIONAL CONGRESS ON GERONTECHNOLOGY
CY AUG, 1991
CL EINDHOVEN, NETHERLANDS
SP EINDHOVEN UNIV TECHNOL, BIOMED & HLTH ORG
RP BRANT, LJ (reprint author), NIA,BALTIMORE,MD 21224, USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU I O S PRESS
PI AMSTERDAM
PA AMSTERDAM
BN 90-5199-072-3
J9 ST HEAL T
PY 1992
VL 3
BP 265
EP 270
PG 6
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA BX03V
UT WOS:A1992BX03V00026
ER

PT J
AU FATATIS, A
   RUSSELL, JT
AF FATATIS, A
   RUSSELL, JT
TI SPONTANEOUS CHANGES IN INTRACELLULAR CALCIUM-CONCENTRATION IN TYPE-I
   ASTROCYTES FROM RAT CEREBRAL-CORTEX IN PRIMARY CULTURE
SO GLIA
LA English
DT Article
DE FURA-2; FLUORESCENCE MICROSCOPY; IMAGE PROCESSING; ASTROGLIA
ID EXCITATORY AMINO-ACIDS; PHORBOL ESTER; CELL-CULTURES; CA-2+;
   OSCILLATIONS; CHANNELS; NEURONS; OLIGODENDROCYTES; GRADIENTS; ANAPHASE
AB Measurement of fura-2 fluorescence in type I astrocytes from rat cerebral cortex showed that the intracellular calcium ion concentration undergoes very large spontaneous changes. These spike-like changes ranged from resting levels of calcium of 50-250 nM to as high as 1-2-mu-M. The spikes were found to be irregular in frequency and amplitude and were frequently synchronous in confluent cultures. The synchronous events appeared as propagating waves that spread over many cells. The spontaneous spikes persisted when the extracellular calcium concentration was reduced to below micromolar levels suggesting that the source for the increases in [Ca2+]i was intracellular. Treatment of the astrocytes with tetrodotoxin did not abolish the spontaneous changes, nor did blockade of voltage-dependent calcium channels with nimodipine and D-600. Ryanodine, a blocker of the sarcoplasmic reticulum calcium-induced calcium release channel, was also without effect. These changes in [Ca2+]i were different in character from both agonist-induced oscillations and depolarization-induced increases in intracellular calcium concentration. Depolarization using 25-100 mM [K+]o resulted in a prompt rise in intracellular calcium concentration, which returned to near resting levels, and this response was sensitive to removal of extracellular calcium and voltage-gated calcium channel antagonists. L-glutamate (0.5-100-mu-M) caused large increases in [Ca2+]i that were associated with discrete periodic oscillations in some cells. The cellular trigger for the spontaneous spikes is currently not understood. We conclude that spontaneous changes in [Ca2+]i in astrocytes are distinct from agonist-induced and membrane potential depolarization-induced changes.
C1 NICHHD,DEV NEUROBIOL LAB,NEURONAL SECRETORY SYST SECT,BLDG 36,ROOM B-316,BETHESDA,MD 20892.
NR 40
TC 71
Z9 72
U1 0
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0894-1491
J9 GLIA
JI Glia
PY 1992
VL 5
IS 2
BP 95
EP 104
DI 10.1002/glia.440050203
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA HG701
UT WOS:A1992HG70100002
PM 1349589
ER

PT J
AU WALTON, LA
   YADUSKY, A
   RUBINSTEIN, L
   ROTH, LM
   YOUNG, RC
AF WALTON, LA
   YADUSKY, A
   RUBINSTEIN, L
   ROTH, LM
   YOUNG, RC
TI STAGE-II CARCINOMA OF THE OVARY - AN ANALYSIS OF SURVIVAL AFTER
   COMPREHENSIVE SURGICAL STAGING AND ADJUVANT THERAPY
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
ID CANCER; LAPAROTOMY
C1 INDIANA UNIV,SCH MED,DEPT PATHOL,INDIANAPOLIS,IN 46202.
   FOX CHASE CANC INST,PHILADELPHIA,PA 19111.
   UNIV ROCHESTER,SCH MED,DEPT OBSTET & GYNECOL,ROCHESTER,NY 14627.
   NCI,BIOMETR RES BRANCH,ROCKVILLE,MD 20852.
RP WALTON, LA (reprint author), UNIV N CAROLINA,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,CB 7570 MACNIDEI,CHAPEL HILL,NC 27599, USA.
NR 21
TC 7
Z9 7
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD JAN
PY 1992
VL 44
IS 1
BP 55
EP 60
DI 10.1016/0090-8258(92)90012-8
PG 6
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA HA838
UT WOS:A1992HA83800012
PM 1730427
ER

PT J
AU HENNINGFIELD, JE
   OBARZANEK, E
AF HENNINGFIELD, JE
   OBARZANEK, E
TI TASK FORCE-2 - METHODS OF ASSESSMENT, STRATEGIES FOR RESEARCH
SO HEALTH PSYCHOLOGY
LA English
DT Article; Proceedings Paper
CT NATIONAL WORKING CONF ON SMOKING AND BODY WEIGHT
CY SEP 10-13, 1990
CL MEMPHIS, TN
SP MEMPHIS STATE UNIV, CTR APPL PSYCHOL RES, NHLBI, SERVIER LABS, LILY RES LABS
C1 NHLBI,BETHESDA,MD 20892.
RP HENNINGFIELD, JE (reprint author), NIDA,LEXINGTON,KY 40583, USA.
RI Perkins, Kenneth/E-4085-2010
NR 0
TC 4
Z9 4
U1 0
U2 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242
SN 0278-6133
J9 HEALTH PSYCHOL
JI Health Psychol.
PY 1992
VL 11
SU S
BP 10
EP 16
DI 10.1037/h0090340
PG 7
WC Psychology, Clinical; Psychology
SC Psychology
GA JK246
UT WOS:A1992JK24600003
PM 1396498
ER

PT J
AU PATTISHALL, EG
AF PATTISHALL, EG
TI SMOKING AND BODY-WEIGHT - REACTIONS AND PERSPECTIVES
SO HEALTH PSYCHOLOGY
LA English
DT Article; Proceedings Paper
CT NATIONAL WORKING CONF ON SMOKING AND BODY WEIGHT
CY SEP 10-13, 1990
CL MEMPHIS, TN
SP MEMPHIS STATE UNIV, CTR APPL PSYCHOL RES, NHLBI, SERVIER LABS, LILY RES LABS
RP PATTISHALL, EG (reprint author), NICHHD,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242
SN 0278-6133
J9 HEALTH PSYCHOL
JI Health Psychol.
PY 1992
VL 11
SU S
BP 32
EP 33
DI 10.1037/h0090343
PG 2
WC Psychology, Clinical; Psychology
SC Psychology
GA JK246
UT WOS:A1992JK24600006
PM 1396501
ER

PT J
AU HENNINGFIELD, JE
AF HENNINGFIELD, JE
TI FOOD AND TOBACCO SELF-ADMINISTRATION - COMMON THEORETICAL ISSUES AND
   RESEARCH PROBLEMS
SO HEALTH PSYCHOLOGY
LA English
DT Meeting Abstract
C1 NIDA,LEXINGTON,KY 40583.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242
SN 0278-6133
J9 HEALTH PSYCHOL
JI Health Psychol.
PY 1992
VL 11
SU S
BP 37
EP 37
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA JK246
UT WOS:A1992JK24600009
ER

PT J
AU RAVUSSIN, E
AF RAVUSSIN, E
TI EFFECT OF SMOKING AND NICOTINE ON ENERGY-EXPENDITURE IN PEOPLE
SO HEALTH PSYCHOLOGY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242
SN 0278-6133
J9 HEALTH PSYCHOL
JI Health Psychol.
PY 1992
VL 11
SU S
BP 46
EP 46
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA JK246
UT WOS:A1992JK24600018
ER

PT J
AU NOGUCHI, S
   OHBA, Y
   OKA, T
AF NOGUCHI, S
   OHBA, Y
   OKA, T
TI THE ROLE OF TRANSCRIPTION AND MESSENGER-RNA STABILITY IN THE REGULATION
   OF EPIDERMAL GROWTH-FACTOR RECEPTOR GENE-EXPRESSION IN REGENERATING
   MOUSE-LIVER
SO HEPATOLOGY
LA English
DT Article
ID RAT-LIVER; RIBONUCLEIC-ACID; PARTIAL-HEPATECTOMY; PROTO-ONCOGENE;
   CELL-LINES; C-MYC; EGF; AMPLIFICATION; CARCINOMA; CANCER
AB The influence of partial hepatectomy on epidermal growth factor receptor gene expression was studied in mouse liver.  Epidermal growth factor receptor binding and epidermal growth factor receptor messenger RNA levels in the liver showed a rapid peak 8 hr after partial hepatectomy, whereas the sham operation had no effects on these levels.  The peak epidermal growth factor receptor messenger RNA level was approximately threefold higher than preoperative values.  The increase in epidermal growth factor receptor messenger RNA levels occurred primarily as a consequence of an increase in the rate of transcription.  Partial hepatectomy slightly increased the half-life of epidermal growth factor receptor messenger RNA in the liver from 2.8 to 3.6 hr.  Treatment of partially hepatectomized mice with cycloheximide increased hepatic epidermal growth factor receptor messenger RNA levels about fivefold by prolonging the half-life of the messenger RNA to 11.2 hr, although this treatment inhibited the increase in transcription induced by partial hepatectomy.  Cycloheximide also increased epidermal growth factor receptor messenger RNA levels in the liver or kidney of sham-operated mice about threefold, primarily through stabilizing epidermal growth factor receptor messenger RNA.  In contrast, cycloheximide had no effects on beta-actin messenger RNA levels in the liver and kidney.  These results suggest that transcription induced by partial hepatectomy requires protein synthesis and that labile proteins are involved in the regulation of the stability of epidermal growth factor receptor messenger RNA.
C1 NIDDKD,MOLEC & CELLULAR BIOL LAB,BLDG 8,ROOM 304,BETHESDA,MD 20892.
NR 48
TC 31
Z9 32
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD JAN
PY 1992
VL 15
IS 1
BP 88
EP 96
DI 10.1002/hep.1840150117
PG 9
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA GX628
UT WOS:A1992GX62800016
PM 1727804
ER

PT B
AU KHACHATURIAN, ZS
AF KHACHATURIAN, ZS
BE Boller, F
   Forette, F
   Khachaturian, Z
   Poncet, M
   Christen, Y
TI AN OVERVIEW OF SCIENTIFIC ISSUES ASSOCIATED WITH THE HETEROGENEITY OF
   ALZHEIMERS-DISEASE
SO HETEROGENEITY OF ALZHEIMERS DISEASE
SE RESEARCH AND PERSPECTIVES IN ALZHEIMERS DISEASE
LA English
DT Proceedings Paper
CT Symposium on Heterogeneity of Alzheimers Disease
CY APR   06, 1992
CL MARSEILLE, FRANCE
C1 NIA,BETHESDA,MD 20892.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN 33
PA HEIDELBERGER PLATZ 3, W-1000 BERLIN 33, GERMANY
BN 3-540-55918-3
J9 RES PER ALZ
PY 1992
BP 1
EP 3
PG 3
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA BZ87G
UT WOS:A1992BZ87G00001
ER

PT B
AU GRAFMAN, J
AF GRAFMAN, J
BE Boller, F
   Forette, F
   Khachaturian, Z
   Poncet, M
   Christen, Y
TI HETEROGENEOUS DISAPPEARANCE OF KNOWLEDGE IN ALZHEIMERS-DISEASE
SO HETEROGENEITY OF ALZHEIMERS DISEASE
SE RESEARCH AND PERSPECTIVES IN ALZHEIMERS DISEASE
LA English
DT Proceedings Paper
CT Symposium on Heterogeneity of Alzheimers Disease
CY APR   06, 1992
CL MARSEILLE, FRANCE
C1 NINCDS,MED NEUROL BRANCH,COGNIT NEUROSCI SECT,BETHESDA,MD 20892.
NR 0
TC 5
Z9 5
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN 33
PA HEIDELBERGER PLATZ 3, W-1000 BERLIN 33, GERMANY
BN 3-540-55918-3
J9 RES PER ALZ
PY 1992
BP 24
EP 32
PG 9
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA BZ87G
UT WOS:A1992BZ87G00004
ER

PT J
AU HARDEN, V
AF HARDEN, V
TI THE NEW POLITICS OF SCIENCE - DICKSON,D
SO HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
LA English
DT Book Review
RP HARDEN, V (reprint author), NIH,OFF HIST,BLDG 31,ROOM 2B09,BETHESDA,MD 20892, USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI LONDON
PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE
SN 0391-9714
J9 HIST PHIL LIFE SCI
JI Hist. Philos. Life Sci.
PY 1992
VL 14
IS 1
BP 188
EP 188
PG 1
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA LB904
UT WOS:A1992LB90400033
ER

PT J
AU HARDEN, VA
AF HARDEN, VA
TI KOCH POSTULATES AND THE ETIOLOGY OF AIDS - AN HISTORICAL-PERSPECTIVE
SO HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
LA English
DT Article; Proceedings Paper
CT 7th Course of the International School of the History of Biological
   Sciences - History of Virology: Biology of Viruses and Epidemiology of
   Viral Diseases
CY JUN 19-28, 1990
CL ISCHIA NAPLES, ITALY
ID MYCOPLASMA-INCOGNITUS; DISEASE; VIRUSES; CELLS; KURU
AB This paper examines the debate over the human immunodeficiency virus (HIV) as the cause of acquired immunodeficiency syndrome (AIDS) from an historical perspective. The changing criteria for proving the link between putative pathological agents and diseases are discussed, beginning with Robert Koch's research on anthrax in the late nineteenth century. Various versions of 'Koch's postulates' are analyzed in relation to the necessity and sufficiency arguments of logical reasoning. In addition, alterations to Koch's postulates are delineated, specifically those required by the discovery of rickettsiae and viruses in the early twentieth century and by the immunological testing developed after midcentury to demonstrate the links between elusive viral agents and two diseases, hepatitis B and infectious mononucleosis. From this perspective, an examination of the AIDS debate is constructed. Molecular biologist Peter Duesberg's argument that HIV is not the cause of AIDS is analyzed in light of his contention that a version of Koch's postulates has not been satisfied. Additional research findings through 1990 relating to the etiology of AIDS are also noted.
C1 NIH,DE WITT STETTEN JR MUSEUM MED RES,BETHESDA,MD 20892.
RP HARDEN, VA (reprint author), NIH,HIST OFF,BLDG 31 ROOM 2B09,BETHESDA,MD 20892, USA.
NR 63
TC 13
Z9 14
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI LONDON
PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE
SN 0391-9714
J9 HIST PHIL LIFE SCI
JI Hist. Philos. Life Sci.
PY 1992
VL 14
IS 2
BP 249
EP 269
PG 21
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA MH209
UT WOS:A1992MH20900002
PM 1342726
ER

PT J
AU LEROITH, D
   SHEMER, J
   ROBERTS, CT
AF LEROITH, D
   SHEMER, J
   ROBERTS, CT
TI EVOLUTIONARY ORIGINS OF INTERCELLULAR COMMUNICATION-SYSTEMS -
   IMPLICATIONS FOR MAMMALIAN BIOLOGY
SO HORMONE RESEARCH
LA English
DT Editorial Material
CT 8TH INTERNATIONAL SYMP ON ENDOCRINOLOGY AND DEVELOPMENT - MULTIPLE
   ENDOCRINE DISEASES : GROWTH HORMONE ACTION : INTERSEXUALITY
CY OCT 11-12, 1991
CL TELFS, AUSTRIA
DE ENDOCRINE; EVOLUTION; NEUROCRINE; PEPTIDE HORMONES
ID ENDOCRINE; INSULIN
AB Traditionally, the two major systems of intercellular communication (i.e. the nervous and endocrine systems) were considered separate functional and anatomical entities. Recent studies have provided evidence that the biochemical elements of these systems have common early phylogenetic origins and have suggested that, with the exception of their anatomical diversity, all the systems of intercellular communication are biochemically similar. On the basis of these findings, we suggest that the overlaps between the nervous and endocrine systems, the widespread tissue production of hormones, and other phenomena are now more easily understood.
RP LEROITH, D (reprint author), NIDKDD,DIABET BRANCH,BETHESDA,MD, USA.
OI Roberts, Charles/0000-0003-1756-5772
NR 10
TC 2
Z9 2
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0301-0163
J9 HORM RES
JI Horm. Res.
PY 1992
VL 38
SU 2
BP 1
EP 6
DI 10.1159/000182583
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA KL253
UT WOS:A1992KL25300001
PM 1292978
ER

PT J
AU MCCUNE, BK
   MULLIN, BR
   FLANDERS, KC
   JAFFURS, WJ
   MULLEN, LT
   SPORN, MB
AF MCCUNE, BK
   MULLIN, BR
   FLANDERS, KC
   JAFFURS, WJ
   MULLEN, LT
   SPORN, MB
TI LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-BETA ISOTYPES IN LESIONS OF
   THE HUMAN BREAST
SO HUMAN PATHOLOGY
LA English
DT Article
DE TRANSFORMING GROWTH FACTOR-BETA; BREAST; BREAST CANCER;
   IMMUNOHISTOCHEMISTRY
ID CANCER CELL-LINES; GENE-EXPRESSION; PARACRINE; IDENTIFICATION;
   ANTIBODIES; CARCINOMA; PATTERN; EMBRYO; RNA
C1 COLUMBIA HOSP WOMEN,WASHINGTON,DC.
   NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
NR 34
TC 99
Z9 100
U1 0
U2 2
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0046-8177
J9 HUM PATHOL
JI Hum. Pathol.
PD JAN
PY 1992
VL 23
IS 1
BP 13
EP 20
DI 10.1016/0046-8177(92)90004-M
PG 8
WC Pathology
SC Pathology
GA HC345
UT WOS:A1992HC34500003
PM 1544664
ER

PT B
AU BENNETT, GJ
   LAIRD, JMA
AF BENNETT, GJ
   LAIRD, JMA
BE WILLIS, WD
TI CENTRAL CHANGES CONTRIBUTING TO NEUROPATHIC HYPERALGESIA
SO HYPERALGESIA AND ALLODYNIA
SE BRISTOL-MYERS SQUIBB SYMPOSIUM ON PAIN RESEARCH SERIES
LA English
DT Proceedings Paper
CT 2ND ANNUAL BRISTOL-MYERS SQUIBB SYMP ON PAIN RESEARCH
CY MAY 20-24, 1991
CL GALVESTON, TX
SP BRISTOL MYERS SQUIBB
RP BENNETT, GJ (reprint author), NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 30,ROOM B20,BETHESDA,MD 20892, USA.
NR 0
TC 6
Z9 6
U1 0
U2 0
PU RAVEN PRESS
PI NEW YORK
PA NEW YORK
BN 0-88167-897-X
J9 SYMP PAIN R
PY 1992
BP 305
EP 310
PG 6
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA BV76M
UT WOS:A1992BV76M00026
ER

PT B
AU RUDA, MA
   DUBNER, R
AF RUDA, MA
   DUBNER, R
BE WILLIS, WD
TI MOLECULAR AND BIOCHEMICAL EVENTS MEDIATE NEURONAL PLASTICITY FOLLOWING
   INFLAMMATION AND HYPERALGESIA
SO HYPERALGESIA AND ALLODYNIA
SE BRISTOL-MYERS SQUIBB SYMPOSIUM ON PAIN RESEARCH SERIES
LA English
DT Proceedings Paper
CT 2ND ANNUAL BRISTOL-MYERS SQUIBB SYMP ON PAIN RESEARCH
CY MAY 20-24, 1991
CL GALVESTON, TX
SP BRISTOL MYERS SQUIBB
RP RUDA, MA (reprint author), NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 30,ROOM B20,BETHESDA,MD 20892, USA.
NR 0
TC 10
Z9 10
U1 0
U2 0
PU RAVEN PRESS
PI NEW YORK
PA NEW YORK
BN 0-88167-897-X
J9 SYMP PAIN R
PY 1992
BP 311
EP 325
PG 15
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA BV76M
UT WOS:A1992BV76M00027
ER

PT J
AU UNSER, M
   ALDROUBI, A
   EDEN, M
AF UNSER, M
   ALDROUBI, A
   EDEN, M
TI POLYNOMIAL SPLINE SIGNAL APPROXIMATIONS - FILTER DESIGN AND ASYMPTOTIC
   EQUIVALENCE WITH SHANNONS SAMPLING THEOREM
SO IEEE TRANSACTIONS ON INFORMATION THEORY
LA English
DT Article
DE INTERPOLATION; B-SPLINES; POLYNOMIAL SPLINES; SPLINE FILTERS; SAMPLING
   THEOREM; LEAST-SQUARES APPROXIMATION; ASYMPTOTIC CONVERGENCE
ID MULTIRESOLUTION
AB The least-squares polynomial spline approximation of a signal g(t) is-an-element-of L2(R) is obtained by projecting g(t) on S(n)(R) (the space of polynomial splines of order n). We show that this process can be linked to the classical problem of cardinal spline interpolation [1] by first convolving g(t) with a B-spline of order n. More specifically, the coefficients of the B-spline interpolation of order 2n + 1 of the sampled filtered sequence are identical to the coefficients of the least-squares approximation of g(t) of order n. We then show that this approximation can be obtained from a succession of three basic operations: prefiltering, sampling, and postfiltering, which confirms the parallel with the classical sampling/reconstruction procedure for bandlimited signals. We determine the frequency responses of these filters for three equivalent spline representations using alternative sets of shift-invariant basis functions of S(n)(R): the standard expansion in terms of B-spline coefficients, a representation in terms of sampled signal values, and a representation using orthogonal basis functions. For the two latter cases, we prove that the frequency response of these filters converge to the ideal lowpass filter pointwise and in all L(p)-norms with 1 less-than-or-equal-to p less-than-or-equal-to infinity as the order of the spline tends to infinity, which establishes the asymptotic equivalence with Shannon's sampling theorem.
RP UNSER, M (reprint author), NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BLDG 13,BETHESDA,MD 20892, USA.
RI Unser, Michael/A-1550-2008; Aldroubi, Akram/J-7186-2012
NR 13
TC 73
Z9 76
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017-2394
SN 0018-9448
J9 IEEE T INFORM THEORY
JI IEEE Trans. Inf. Theory
PD JAN
PY 1992
VL 38
IS 1
BP 95
EP 103
DI 10.1109/18.108253
PG 9
WC Computer Science, Information Systems; Engineering, Electrical &
   Electronic
SC Computer Science; Engineering
GA GV096
UT WOS:A1992GV09600010
ER

PT B
AU CLERICI, M
   SHEARER, GM
AF CLERICI, M
   SHEARER, GM
BE JANOSSY, G
   AUTRAN, B
   MIEDEMA, F
TI THE USE OF INVITRO T-CELL IMMUNE FUNCTION TO MONITOR THE COURSE OF
   HIV-INFECTION
SO IMMUNODEFICIENCY IN HIV INFECTION AND AIDS
LA English
DT Proceedings Paper
CT WORKSHOP ON IMMUNODEFICIENCY IN HIV-1 INFECTIONS
CY MAY 03-04, 1991
CL WINDSOR, ENGLAND
SP EUROPEAN COMMUNITY, FEDERAT EUROPEAN RES SOCIETIES, MED RES COUNCIL
RP CLERICI, M (reprint author), NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892, USA.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5547-4
PY 1992
BP 64
EP 75
PG 12
WC Immunology; Pathology; Virology
SC Immunology; Pathology; Virology
GA BW16J
UT WOS:A1992BW16J00007
ER

PT B
AU PANTALEO, G
   GRAZIOSI, C
   BUTINI, L
   FAUCI, AS
AF PANTALEO, G
   GRAZIOSI, C
   BUTINI, L
   FAUCI, AS
BE JANOSSY, G
   AUTRAN, B
   MIEDEMA, F
TI ROLE OF CD8+ LYMPHOCYTES-T IN THE PATHOGENESIS OF HIV-INFECTION
SO IMMUNODEFICIENCY IN HIV INFECTION AND AIDS
LA English
DT Proceedings Paper
CT WORKSHOP ON IMMUNODEFICIENCY IN HIV-1 INFECTIONS
CY MAY 03-04, 1991
CL WINDSOR, ENGLAND
SP EUROPEAN COMMUNITY, FEDERAT EUROPEAN RES SOCIETIES, MED RES COUNCIL
RP PANTALEO, G (reprint author), NIAID,IMMUNOREGULAT LAB,BLDG 10,ROOM 11B 13,BETHESDA,MD 20892, USA.
RI Pantaleo, Giuseppe/K-6163-2016
NR 0
TC 1
Z9 1
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5547-4
PY 1992
BP 211
EP 218
PG 8
WC Immunology; Pathology; Virology
SC Immunology; Pathology; Virology
GA BW16J
UT WOS:A1992BW16J00019
ER

PT B
AU POLI, G
   FAUCI, AS
AF POLI, G
   FAUCI, AS
BE JANOSSY, G
   AUTRAN, B
   MIEDEMA, F
TI CYTOKINES AND IMMUNOREGULATORY FACTORS IN THE PATHOGENESIS OF
   HIV-INFECTION - TNF EFFECTS
SO IMMUNODEFICIENCY IN HIV INFECTION AND AIDS
LA English
DT Proceedings Paper
CT WORKSHOP ON IMMUNODEFICIENCY IN HIV-1 INFECTIONS
CY MAY 03-04, 1991
CL WINDSOR, ENGLAND
SP EUROPEAN COMMUNITY, FEDERAT EUROPEAN RES SOCIETIES, MED RES COUNCIL
RP POLI, G (reprint author), NIAID,IMMUNOREGULAT LAB,BLDG 10,ROOM 11B 13,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5547-4
PY 1992
BP 278
EP 287
PG 10
WC Immunology; Pathology; Virology
SC Immunology; Pathology; Virology
GA BW16J
UT WOS:A1992BW16J00025
ER

PT J
AU MILLER, AE
   ENNIST, DL
   OZATO, K
   WESTPHAL, H
AF MILLER, AE
   ENNIST, DL
   OZATO, K
   WESTPHAL, H
TI ACTIVATION OF IMMUNOGLOBULIN CONTROL ELEMENTS IN TRANSGENIC MICE
SO IMMUNOGENETICS
LA English
DT Article
ID HEAVY-CHAIN ENHANCER; B-CELL GROWTH; LYMPHOCYTES-B; SEQUENCE ELEMENTS;
   PROTEIN-BINDING; LYMPHOID-CELLS; CHLORAMPHENICOL ACETYLTRANSFERASE;
   DIFFERENTIATION FACTORS; RIBONUCLEIC-ACID; GENE-EXPRESSION
AB To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, E-mu-kCAT, contains the Ig heavy chain enhancer (E-mu) and the kappa-light chain promoter driving the chloramphenicol acetyltransferase (CAT) gene. In the other, DELTA-E-mu-kCAT, CAT is under the control of the kappa-promoter alone. E-mu and kappa-relative activity were assessed by CAT assay. In E-mu-kCAT mice, low CAT expression was consistently found in spleen, bone marrow, mesenteric lymph node, and thymus but not in brain, lung, or kidney. In DELTA-E-mu-kCAT mice, CAT expression was detectable just above background in lymphoid tissues, suggesting a basic level of tissue specificity in the absence of the enhancer. Whole spleen cell cultures prepared from the mice were treated with lymphokines and mitogens. Lipopolysaccharide (LPS), concanavilin A (Con A), interleukin 6 (IL-6), and interferon-gamma (IFN-gamma) increased CAT expression to varying extents in cells derived from E-mu-kCAT mice but not in spleen cells prepared from DELTA-E-mu-kCAT mice. Thus, the presence of E-mu, in addition to the kappa-promoter, is essential for the stimulation of CAT expression mediated by these factors. B cells from E-mu-kCAT mice were separated by density into populations of small and large cells. In untreated small B cells, no CAT expression was detected and only addition of LPS resulted in an increase in CAT expression. In large B cells, CAT was expressed at a low level without addition of exogenous factors. Incubation with LPS, IL-6, Con A and IFN-gamma caused CAT expression to increase several-fold. This transgenic system provides a means to identify exogenous factors that activate Ig enhancers and promoters.
C1 NICHHD,DEV & MOLEC IMMUN LAB,BETHESDA,MD 20892.
RP MILLER, AE (reprint author), NICHHD,MAMMALIAN GENES & DEV LAB,BLDG 6,RM 420,BETHESDA,MD 20892, USA.
NR 64
TC 21
Z9 21
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0093-7711
J9 IMMUNOGENETICS
JI Immunogenetics
PD JAN
PY 1992
VL 35
IS 1
BP 24
EP 32
PG 9
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA GU198
UT WOS:A1992GU19800004
PM 1729170
ER

PT J
AU MAGE, RG
   YOUNGCOOPER, GO
   ALEXANDER, CB
   HANLY, WC
   NEWMAN, BA
AF MAGE, RG
   YOUNGCOOPER, GO
   ALEXANDER, CB
   HANLY, WC
   NEWMAN, BA
TI A NEW VH-CH RECOMBINANT IN THE RABBIT
SO IMMUNOGENETICS
LA English
DT Note
ID CHROMOSOME-14; ALLOTYPES; JH
C1 UNIV ILLINOIS,COLL MED,DEPT MICROBIOL & IMMUNOL,CHICAGO,IL 60612.
RP MAGE, RG (reprint author), NIAID,IMMUNOL LAB,BETHESDA,MD 20892, USA.
NR 16
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0093-7711
J9 IMMUNOGENETICS
JI Immunogenetics
PD JAN
PY 1992
VL 35
IS 2
BP 131
EP 135
PG 5
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA HA799
UT WOS:A1992HA79900008
PM 1346525
ER

PT J
AU ABOUD, M
   SEGAL, S
   PRIEL, E
   BLAIR, DG
   OHARA, B
AF ABOUD, M
   SEGAL, S
   PRIEL, E
   BLAIR, DG
   OHARA, B
TI EFFECT OF TEMPERATURE ON THE EXPRESSION OF MAJOR HISTOCOMPATIBILITY
   COMPLEX CLASS-I ANTIGENS
SO IMMUNOLOGICAL INVESTIGATIONS
LA English
DT Article
ID STRESS PROTEINS; BINDING-PROTEIN; PEPTIDE BINDING; MHC; REGION; GENES;
   CELLS; SUSCEPTIBILITY; TRANSPORTERS; METASTASIS
AB In the present study we investigated the effect of temperature on MHC class-I gene expression in BALK/C 3T3 cells incubated for 5 days at 34-degrees-C, 37-degrees-C and 39-degrees-C. FACS analysis revealed no significant difference in the cell surface expression of any of the 3 major class-I antigens at 34-degrees-C and 37-degrees-C. Strikingly, however, when the level of the respective mRNA was determined, only that of the H-2K was comparable at both temperatures, whereas the levels of the H-2D and H-2L mRNA were profoundly higher at 37-degrees-C. These data appear to reflect a differential temperature-related transcriptional control of the different class-I genes or a different temperature effect on the stability of their mRNA. The absence of a parallel increase in surface expression of the corresponding H-2D and H-2L antigens may result from some translational or post-translational limiting factors. At 39-degrees-C, however, these limiting factors seem to be overcome since the surface expression of all the 3 antigens was remarkably increased although the level of their encoding mRNA was rather lower than in 37-degrees-C. This stimulatory effect might be ascribed to heat shock proteins which are known to arise in cells at heat or other stress conditions. They participate in assembly and disassembly assembly of various protein complexes and in transport of certain proteins across intracellular membranes. such proteins may have arisen in our cells at 39-degrees-C and facilitated the intracellular assembly of the class-I molecules and their transport to the cell surface. The possible implication of such heat shock proteins in the anti-tumor effect of hyperthermia is discussed.
C1 NCI,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702.
   YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT GENET,BRONX,NY 10461.
RP ABOUD, M (reprint author), BEN GURION UNIV NEGEV,FAC HLTH SCI,DEPT MICROBIOL & IMMUNOL,BEER SHEVA,ISRAEL.
NR 41
TC 1
Z9 1
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0882-0139
J9 IMMUNOL INVEST
JI Immunol. Invest.
PY 1992
VL 21
IS 3
BP 219
EP 229
DI 10.3109/08820139209072260
PG 11
WC Immunology
SC Immunology
GA HT140
UT WOS:A1992HT14000004
PM 1587557
ER

PT J
AU JAMES, SL
AF JAMES, SL
TI EXPERIMENTAL-MODELS OF IMMUNIZATION AGAINST SCHISTOSOMES - LESSONS FOR
   VACCINE DEVELOPMENT
SO IMMUNOLOGICAL INVESTIGATIONS
LA English
DT Article
ID RADIATION-ATTENUATED CERCARIAE; P-STRAIN MICE; LUNG-PHASE IMMUNITY;
   NON-LIVING VACCINE; PROTECTIVE IMMUNITY; IRRADIATED CERCARIAE; INDUCED
   RESISTANCE; NONLIVING VACCINE; MANSONI INFECTION; IMMUNOCHEMICAL
   CHARACTERIZATION
AB Schistosomiasis is a debilitating, and sometimes deadly, parasitic infection that afflicts hundreds of millions of people living in developing countries. One of the best hopes for control of this disease is vaccine development. Studies on experimental models of attenuated vaccines have proven that high levels of protective immunity can be achieved. In these systems, resistance has been shown to be directed against the migrating larval stages of the parasite and to have both cellular and humoral components. Several candidate vaccine immunogens have been identified on the basis of antibody reactivity. However, the level of protection induced by immunization with nonliving vaccines has at yet not approached the level observed with attenuated infection. Current challenges to vaccine development include identification of protective T cell immunogens, determination of ways to strengthen the immungenicity of isolated parasite antigens, and development of methodologies to selectively stimulate protective, as opposed to ineffective or even detrimental, immune responses.
RP JAMES, SL (reprint author), NIAID,IMMUNOL & CELL BIOL SECT,PARASIT DIS LAB,BETHESDA,MD 20892, USA.
NR 69
TC 15
Z9 15
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0882-0139
J9 IMMUNOL INVEST
JI Immunol. Invest.
PY 1992
VL 21
IS 5
BP 477
EP 493
DI 10.3109/08820139209069385
PG 17
WC Immunology
SC Immunology
GA JQ485
UT WOS:A1992JQ48500007
PM 1428021
ER

PT J
AU HARRIMAN, GR
   HORNQVIST, E
   LYCKE, NY
AF HARRIMAN, GR
   HORNQVIST, E
   LYCKE, NY
TI ANTIGEN-SPECIFIC AND POLYCLONAL CD4+ LAMINA PROPRIA T-CELL LINES -
   PHENOTYPIC AND FUNCTIONAL-CHARACTERIZATION
SO IMMUNOLOGY
LA English
DT Article
ID RAT SMALL-INTESTINE; LYMPHOCYTE-T; INTRAEPITHELIAL LYMPHOCYTES;
   CHOLERA-TOXIN; MONOCLONAL-ANTIBODIES; MUCOSAL LYMPHOCYTES;
   NONHUMAN-PRIMATES; IFN-GAMMA; EXPRESSION; MOUSE
AB Surface phenotype and function of lamina propria CD4+ T cells have been evaluated.  In addition, long-term, antigen-specific and polyclonal lamina propria CD4+ T-cell lines have been generated and characterized.  Lamina propria CD4+ T cells represent approximately 30% of lamina propria lymphocytes and are responsive to a variety of T-cell mitogens, including anti-CD3, concanavalin A, phytohaemagglutinin and pokeweed mitogen.  In each case, however, lamina propria T cells are less responsive to these mitogens than spleen T cells.  Freshly isolated lamina propria T cells produce substantial amounts of interleukin-2 (IL-2), interleukin-4 (IL-4), gamma interferon and to a lesser extent interleukin-5 (IL-5).  Antigen-specific lamina propria CD4+ T-cell lines were generated by orally immunizing animals with antigen (KLH) in conjunction with cholera toxin as an oral adjuvant.  Polyclonal lamina propria CD4+ T-cell lines were generated from unimmunized animals using anti-CD3 as a polyclonal stimulus.  Both antigen-specific and polyclonal CD4+ T-cell lines were Thy-1+, alpha-beta-TCR+ and CD8-.  The antigen-specific CD4+ T-cell line when stimulated by anti-CD3 and PMA produces predominantly IL-2, IL-4 and gamma interferon, with very little IL-5.  In contrast, the polyclonal CD4+ T-cell line when similarly stimulated produces predominantly IL-4 and IL-5, with very little IL-2 and no detectable gamma interferon.  In summary, lamina propria CD4+ T cells have been evaluated and in vitro conditions have been determined for successful generation of lamina propria CD4+ T-cell lines.
C1 GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,GULDHEDSGATAN 10,S-41346 GOTHENBURG,SWEDEN.
   NIAID,CLIN INVEST LAB,BETHESDA,MD 20892.
NR 42
TC 53
Z9 53
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL
SN 0019-2805
J9 IMMUNOLOGY
JI Immunology
PD JAN
PY 1992
VL 75
IS 1
BP 66
EP 73
PG 8
WC Immunology
SC Immunology
GA GZ979
UT WOS:A1992GZ97900011
PM 1371494
ER

PT J
AU BARD, KA
   PLATZMAN, KA
   LESTER, BM
   SUOMI, SJ
AF BARD, KA
   PLATZMAN, KA
   LESTER, BM
   SUOMI, SJ
TI ORIENTATION TO SOCIAL AND NONSOCIAL STIMULI IN NEONATAL CHIMPANZEES AND
   HUMANS
SO INFANT BEHAVIOR & DEVELOPMENT
LA English
DT Article
ID PAN-TROGLODYTES; COMMUNICATION; BEHAVIOR; INFANTS
AB The behavioral capabilities of neonatal chimpanzees are not well known. A major goal this study was to document their ability to orient to social and nonsocial objects and to compare their performance with that of human infants. The Brazelton Neonatal Behavioral Assessment Scale (NBAS) was administered to 13 nursery-reared chimpanzees, every other day during their first month of life, and to 42 humans, twice, on the third and thirtieth day of life. The orientation items included social stimuli (a human face and both human and chimpanzee sounds) and nonsocial stimuli (a red ball and a red rattle). Repeated-measures analysis of variance on the orientation cluster of the NBAS revealed that chimpanzee neonates have the capacity for sustained attention to all stimuli, both social and nonsocial, indistinguishable from that of human neonates. Significant improvements in orientation performance from Day 2 to Day 30 were found for both species.  These striking similarities in early orientation ability are viewed as a challange to notions of unique human propensities.
C1 EMORY UNIV,SCH MED,ATLANTA,GA 30322.
   BROWN UNIV,EMMA PENDLETON BRADLEY HOSP,PROVIDENCE,RI 02912.
   BROWN UNIV,WOMEN & INFANTS HOSP,PROVIDENCE,RI 02912.
   NIH,COMPARAT ETHOL LAB,BETHESDA,MD 20892.
RP BARD, KA (reprint author), EMORY UNIV,YERKES REG PRIMATE RES CTR,ATLANTA,GA 30322, USA.
NR 51
TC 48
Z9 49
U1 0
U2 1
PU ABLEX PUBL CORP
PI NORWOOD
PA 355 CHESTNUT ST, NORWOOD, NJ 07648
SN 0163-6383
J9 INFANT BEHAV DEV
JI Infant Behav. Dev.
PD JAN-MAR
PY 1992
VL 15
IS 1
BP 43
EP 56
DI 10.1016/0163-6383(92)90005-Q
PG 14
WC Psychology, Developmental
SC Psychology
GA HQ657
UT WOS:A1992HQ65700004
ER

PT J
AU LAMB, ME
   STERNBERG, KJ
   PRODROMIDIS, M
AF LAMB, ME
   STERNBERG, KJ
   PRODROMIDIS, M
TI NONMATERNAL CARE AND THE SECURITY OF INFANT MOTHER ATTACHMENT - A
   REANALYSIS OF THE DATA
SO INFANT BEHAVIOR & DEVELOPMENT
LA English
DT Article
DE ATTACHMENT; DAY CARE; NONMATERNAL CARE
ID EMPLOYMENT; SAMPLE
AB Data from 13 studies (N = 897) were combined to allow tests of the associations between the experience of, extent of, and onset of nonmaternal care and the security of infant-mother attachment as assessed in the Strange Situation between 11 and 24 months of age. Secure attachments were significantly more common among infants in exclusive maternal core than among those who experienced regular nonmaternal core for more than 5 hrs per week, and ratings of avoidance were also higher among those receiving regular nonmaternal core. Insecure attachments were significantly more common among those infants assessed above 15 months of age and among those who entered care between 7 and 12 months of age, rather than before. Extent of nonmaternal care was not significantly associated with attachment classifications; insecure attachments were not more common among those in care for more rather than less than 20 hrs per week. However, log-linear analysis revealed a complex interaction between age of assessment and extent of core, such that part-time care (relative to full-time care) was associated with insecurity among those assessed at older ages and with security among those assessed at younger ages.
RP LAMB, ME (reprint author), NICHHD,LCE,SSED,9190 ROCKVILLE PIKE,BETHESDA,MD 20814, USA.
NR 31
TC 28
Z9 28
U1 1
U2 4
PU ABLEX PUBL CORP
PI NORWOOD
PA 355 CHESTNUT ST, NORWOOD, NJ 07648
SN 0163-6383
J9 INFANT BEHAV DEV
JI Infant Behav. Dev.
PD JAN-MAR
PY 1992
VL 15
IS 1
BP 71
EP 83
DI 10.1016/0163-6383(92)90007-S
PG 13
WC Psychology, Developmental
SC Psychology
GA HQ657
UT WOS:A1992HQ65700006
ER

PT J
AU HACKSTADT, T
   MESSER, R
   CIEPLAK, W
   PEACOCK, MG
AF HACKSTADT, T
   MESSER, R
   CIEPLAK, W
   PEACOCK, MG
TI EVIDENCE FOR PROTEOLYTIC CLEAVAGE OF THE 120-KILODALTON OUTER-MEMBRANE
   PROTEIN OF RICKETTSIAE - IDENTIFICATION OF AN AVIRULENT MUTANT DEFICIENT
   IN PROCESSING
SO INFECTION AND IMMUNITY
LA English
DT Article
ID TYPHUS GROUP RICKETTSIAE; SURFACE-ARRAY PROTEINS; CELL-ENVELOPE PROTEIN;
   MONOCLONAL-ANTIBODIES; SPOTTED-FEVER; GENE; PROWAZEKI; ANTIGENS;
   IMMUNOPRECIPITATION; POLYPEPTIDE
AB The 120-kDa rickettsial outer membrane protein (rOmpB) is encoded by a gene with the capacity to encode a protein of approximately 168 kDa.  The carboxy-terminal end of the molecule is apparently cleaved to yield 120- and 32-kDa products.  Both polypeptides are surface exposed and remain associated with the outer membrane of intact rickettsiae.  All species of rickettsiae examined display similar cleavage of rOmpB.  Comparison of diverse species of rickettsiae demonstrate a conserved N terminus of the 32-kDa fragment, with a predicted procaryotic secretory signal peptide immediately upstream of the proposed cleavage site.  Coprecipitation of the 120-kDa rOmpB protein and the 32-kDa peptide by monoclonal antibodies specific for the 120-kDa portion of the molecule suggests that the two fragments remain noncovalently associated on the surface of rickettsiae.  Analysis of an avirulent mutant of Rickettsia rickettsii revealed reduced amounts of the 120- and 32-kDa fragments, but with a correspondingly larger rOmpB protein that displayed properties expected of the putative precursor.  This avirulent mutant grows intracellularly but fails to cause the lysis of infected cells that is typical of R. rickettsii.  DNA sequence analysis of the region of the gene encoding the cleavage site of the avirulent strain revealed no difference from the sequence obtained from virulent R. rickettsii.  The 168-kDa putative precursor of the avirulent strain of R. rickettsii was not extracted from the surface by dilute buffers, as is the 120-kDa protein of virulent R. rickettsii or R. prowazekii.  These latter results suggest that the 32-kDa C-terminal region of the molecule may serve as a membrane anchor domain.
C1 NIAID,ROCKY MT LABS,VECTORS & PATHOGENS LAB,HAMILTON,MT 59840.
RP HACKSTADT, T (reprint author), NIAID,ROCKY MT LABS,INTRACELLULAR PARASITES LAB,HAMILTON,MT 59840, USA.
NR 37
TC 91
Z9 96
U1 1
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD JAN
PY 1992
VL 60
IS 1
BP 159
EP 165
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA GW974
UT WOS:A1992GW97400024
PM 1729180
ER

PT B
AU NUSSENBLATT, RB
   DAVIS, JL
   PALESTINE, AG
AF NUSSENBLATT, RB
   DAVIS, JL
   PALESTINE, AG
BE BOKE, WRF
   MANTHEY, KF
   NUSSENBLATT, RB
TI CHORIORETINAL BIOPSY FOR DIAGNOSTIC PURPOSES IN CASES OF INTRAOCULAR
   INFLAMMATORY DISEASE
SO INTERMEDIATE UVEITIS
SE DEVELOPMENTS IN OPHTHALMOLOGY
LA English
DT Proceedings Paper
CT INTERNATIONAL WORKSHOP ON INTERMEDIATE UVEITIS
CY JUL 05-06, 1990
CL GUTERSLOH, GERMANY
SP UNIV KIEL, DEPT OPHTHALMOL, BERTELSMANN FDN
RP NUSSENBLATT, RB (reprint author), NEI,IMMUNOL LAB,BLDG 10,ROOM 10N202,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 2
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5436-2
J9 DEV OPHTHALMOL
PY 1992
VL 23
BP 133
EP 138
PG 6
WC Medicine, Research & Experimental; Ophthalmology; Pharmacology &
   Pharmacy
SC Research & Experimental Medicine; Ophthalmology; Pharmacology & Pharmacy
GA BU53U
UT WOS:A1992BU53U00022
PM 1730345
ER

PT B
AU NUSSENBLATT, RB
   PALESTINE, AG
AF NUSSENBLATT, RB
   PALESTINE, AG
BE BOKE, WRF
   MANTHEY, KF
   NUSSENBLATT, RB
TI CICLOSPORIN (SANDIMMUN) THERAPY - EXPERIENCE IN THE TREATMENT OF PARS
   PLANITIS AND PRESENT THERAPEUTIC GUIDELINES
SO INTERMEDIATE UVEITIS
SE DEVELOPMENTS IN OPHTHALMOLOGY
LA English
DT Proceedings Paper
CT INTERNATIONAL WORKSHOP ON INTERMEDIATE UVEITIS
CY JUL 05-06, 1990
CL GUTERSLOH, GERMANY
SP UNIV KIEL, DEPT OPHTHALMOL, BERTELSMANN FDN
RP NUSSENBLATT, RB (reprint author), NEI,IMMUNOL LAB,BLDG 10,ROOM 10N202,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 0
TC 7
Z9 8
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5436-2
J9 DEV OPHTHALMOL
PY 1992
VL 23
BP 177
EP 184
PG 8
WC Medicine, Research & Experimental; Ophthalmology; Pharmacology &
   Pharmacy
SC Research & Experimental Medicine; Ophthalmology; Pharmacology & Pharmacy
GA BU53U
UT WOS:A1992BU53U00030
PM 1730354
ER

PT J
AU AMITAL, H
   KLEMPERER, I
   BLANK, M
   YASSUR, Y
   PALESTINE, A
   NUSSENBLATT, RB
   SHOENFELD, Y
AF AMITAL, H
   KLEMPERER, I
   BLANK, M
   YASSUR, Y
   PALESTINE, A
   NUSSENBLATT, RB
   SHOENFELD, Y
TI ANALYSIS OF AUTOANTIBODIES AMONG PATIENTS WITH PRIMARY AND SECONDARY
   UVEITIS - HIGH-INCIDENCE IN PATIENTS WITH SARCOIDOSIS
SO INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
LA English
DT Article
DE ANTI-DNA; AUTOANTIBODIES; SARCOIDOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;
   UVEITIS
ID ANTIBODY
AB The sera of 122 patients with uveitis were examined for the presence of various antinuclear autoantibodies. Overall 21.3% of the patients had antibodies to ribonucleoprotein (RNP) and 18% to Ro (SSA). When subdividing the patients according to primary uveitis versus secondary uveitis, the autoantibodies were detected more frequently in the second group [anti-RNP 13.3 vs. 31.4%, anti-Ro (SSA) 11.8 vs. 27.7%, anti-Sm 10.3 vs. 24% and poly (G) 2.9 vs. 14.8%, respectively]. No differences could be asserted in autoantibody frequencies according to disease location within the uvea. Among uveitis patients afflicted with sarcoidosis a particular high incidence of autoantibodies was detected in comparison with all other subgroups of patients with uveitis. Although the presence of autoantibodies among patients with uveitis appears not to have a major diagnostic value, their assessment may aid to a better understanding of disease pathogenesis.
C1 TEL AVIV UNIV,SCH MED,SHEBA MED CTR,DEPT MED B,AUTOIMMUNE DIS RES UNIT,IL-52621 TEL HASHOMER,ISRAEL.
   BEN GURION UNIV NEGEV,SOROKA MED CTR,FAC HLTH SCI,DEPT OPHTHALMOL,IL-84120 BEER SHEVA,ISRAEL.
   NEI,BETHESDA,MD 20892.
NR 15
TC 6
Z9 6
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-2438
J9 INT ARCH ALLERGY IMM
JI Int. Arch. Allergy Immunol.
PY 1992
VL 99
IS 1
BP 34
EP 36
PG 3
WC Allergy; Immunology
SC Allergy; Immunology
GA KD745
UT WOS:A1992KD74500005
PM 1483065
ER

PT J
AU SEGAL, DM
   QIAN, JH
   TITUS, JA
   MORENO, MB
   GEORGE, AJT
   JOST, CR
   KURUCZ, I
   ELGAMIL, M
   WUNDERLICH, JR
AF SEGAL, DM
   QIAN, JH
   TITUS, JA
   MORENO, MB
   GEORGE, AJT
   JOST, CR
   KURUCZ, I
   ELGAMIL, M
   WUNDERLICH, JR
TI TARGETED CYTOKINE PRODUCTION
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article; Proceedings Paper
CT CONF ON BISPECIFIC ANTIBODIES AND TARGETED CELLULAR CYTOTOXICITY
CY JUN 13-17, 1992
CL OSTUNI, ITALY
SP EUROPEAN COMMUNITY CONCERTED ACT, CULTURAL ASSOC FRONTIERE SCI, CILAG
ID CYTOTOXIC LYMPHOCYTES-T; B-CELL LYMPHOMA; BISPECIFIC ANTIBODIES;
   MONOCLONAL-ANTIBODIES; CYTOLYTIC ACTIVITY; EFFECTOR-CELLS; TUMOR-GROWTH;
   ACTIVATION; MICE; ANTI-CD3
AB It has been well established that bispecific antibodies containing anti-T-cell receptor MAbs crosslinked to anti-tumor MAbs induce T cells to lyse tumor cells, as measured in a Cr-51-release assay. Such lysis requires direct attachment between target and cytotoxic cells and most probably involves the exocytosis of cytolytic substances into the cell:cell interface. In addition, targeted T cells mediate a second activity, the secretion into the medium of factors that can block the growth of bound tumor cells and unbound bystander cells. In order to test how targeted effector cells mediate anti-tumor effects in vivo, we are currently developing a totally syngeneic murine system in which murine T cells are targeted against mouse mammary tumors. The system allows us to treat both primary tumors and tumor transplants, using a mammary-tumor-virus antigen as the entity that is specifically recognized on the tumor cells.
RP SEGAL, DM (reprint author), NIH,EXPTL IMMUNOL BRANCH,BLDG 10,ROOM 4B17,BETHESDA,MD 20892, USA.
OI George, Andrew/0000-0002-2866-0241
NR 21
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PY 1992
SU 7
BP 36
EP 38
PG 3
WC Oncology
SC Oncology
GA JY980
UT WOS:A1992JY98000009
ER

PT J
AU KELLER, JR
   JACOBSEN, SEW
   DUBOIS, CM
   HESTDAL, K
   RUSCETTI, FW
AF KELLER, JR
   JACOBSEN, SEW
   DUBOIS, CM
   HESTDAL, K
   RUSCETTI, FW
TI TRANSFORMING GROWTH-FACTOR-BETA - A BIDIRECTIONAL REGULATOR OF
   HEMATOPOIETIC-CELL GROWTH
SO INTERNATIONAL JOURNAL OF CELL CLONING
LA English
DT Review
DE HEMATOPOIETIC REGULATION; TRANSFORMING GROWTH FACTOR-BETA; RECEPTOR
   MODULATION; CYTOKINES; HEMATOPOIESIS; LEUKEMIC CELL GROWTH;
   COLONY-STIMULATING FACTORS
ID ACUTE MYELOBLASTIC-LEUKEMIA; COLONY-STIMULATING FACTOR; HUMAN MARROW
   CULTURES; PROGENITOR CELLS; TGF-BETA; BONE-MARROW; POTENT INHIBITOR;
   TISSUE-REPAIR; FORMING CELLS; 2 FORMS
AB It is now apparent that the transforming growth factor-beta (TGF-beta) family of proteins has potent hematopoietic regulatory properties ranging from effects on the growth and differentiation of primitive stem cells to the differentiated functions of mature cells. Although most reports have described the inhibitory activities of TGF-beta on hematopoiesis, recent evidence supports the concept that TGF-beta can have both inhibitory and stimulatory actions on these systems. These differences depend on the differentiation state of the target cell and the other cytokines interacting with the cell. Furthermore, TGF-beta has direct bidirectional effects on cell surface expression of many cytokine receptors suggesting that it is part of the mechanism of action of TGF-beta. The major biological effect of TGF-beta on hematopoietic cell growth is the reversible inhibition of entry into the cell cycle. Importantly, the effect of in vivo administration of TGF-beta has mimicked the in vitro effects. Ultimately, well designed clinical trials will determine whether the exciting potential of TGF-beta can be used to treat or prevent myelotoxicity and other bone marrow dysfunctions.
C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21701.
   PRI DYNCORP INC,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD.
NR 69
TC 69
Z9 70
U1 0
U2 0
PU ALPHAMED PRESS
PI DAYTON
PA 4100 S KETTERING BLVD, DAYTON, OH 45439-2092
SN 0737-1454
J9 INT J CELL CLONING
PD JAN
PY 1992
VL 10
IS 1
BP 2
EP 11
PG 10
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA HB257
UT WOS:A1992HB25700001
PM 1552222
ER

PT J
AU WISEMAN, CV
   GRAY, JJ
   MOSIMANN, JE
   AHRENS, AH
AF WISEMAN, CV
   GRAY, JJ
   MOSIMANN, JE
   AHRENS, AH
TI CULTURAL EXPECTATIONS OF THINNESS IN WOMEN - AN UPDATE
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article; Proceedings Paper
CT CONVENTION OF THE EASTERN PSYCHOLOGICAL ASSOC
CY MAR, 1990
CL PHILADELPHIA, PA
SP E PSYCHOL ASSOC
AB An investigation of current American society's depiction of the ideal female body was performed.  Body measurements of Playboy magazine centerfolds and Miss America contestants for 1979-1988 indicated body weight 13-19% below expected weight for women in that age group.  Miss America contestants showed a significant decrease in expected weight between 1979 and 1988.  Comparisons were made with an earlier study which had demonstrated that body measurements of both groups had decreased during the period 1959-1978.  Diet-for-weight-loss and exercise articles in six women's magazines were tabulated for 1959-1988.  A significant increase in both diet articles and exercise articles occurred during this period.  These findings suggest that the overvaluation of thinness continues and thinness is now sought through both dieting and exercise.
C1 AMERICAN UNIV,DEPT PSYCHOL,ASBURY BLDG,WASHINGTON,DC 20016.
   NIH,DIV COMP,STAT & MATH METHODOL LAB,BETHESDA,MD 20892.
NR 9
TC 319
Z9 322
U1 1
U2 20
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0276-3478
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD JAN
PY 1992
VL 11
IS 1
BP 85
EP 89
DI 10.1002/1098-108X(199201)11:1<85::AID-EAT2260110112>3.0.CO;2-T
PG 5
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
SC Psychology; Nutrition & Dietetics; Psychiatry
GA GW218
UT WOS:A1992GW21800010
ER

PT J
AU SEI, Y
   SKOLNICK, P
   ARORA, PK
AF SEI, Y
   SKOLNICK, P
   ARORA, PK
TI STRAIN VARIATION IN IMMUNE-RESPONSE AND BEHAVIOR FOLLOWING THE DEATH OF
   CAGE COHORTS
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE IMMUNE MODULATION; ANXIETY; ANIMAL BEHAVIOR; CANNIBALISM; DEFENSIVE
   BURYING; FIGHTING; MOUNTING
ID PLUS-MAZE; STRESS; SUPPRESSION; DEPRESSION; DIAZEPAM; ANXIETY; MICE
AB Strain differences in both immune function and behavior were observed following exposure of mice to the death of cage-cohorts. AKR/J, BALB/cN, and C3H/HeJ mice were exposed to a dead cohort for two hours at 48 hour intervals for 30 days. During this two hour period, AKR/J mice displayed intense fighting and mounting behavior. In addition, these mice attacked, cannibalized, and buried carcasses. Neither C3H/HeJ nor BALB/cN mice exhibited the complete repertoire of behaviors directed at either carcasses or cage-cohorts observed in AKR/J mice. After 15 exposures to the death of cage-cohorts, allogeneic cytotoxic T-lymphocyte (CTL) response was suppressed in AKR/J mice, but was enhanced or unchanged in C3H/HeJ and BALB/cN mice, respectively. Other immune parameters including natural killer (NK) cell activity, and lipopolysaccharide-stimulated B cell proliferation were unchanged in AKR/J mice but increased in BALB/cN mice exposed to the death of cage-cohorts for thirty days. These results suggest: 1) that both suppression of the CTL response and behaviors indicative of defensive burying in AKR/J mice may specifically be due to the loss of cage-cohorts, since they were not observed following exposure of these mice to the death of contraspecific animals; and 2) that both the behavioral repertoire and immune responses following exposure to the death of cage-cohorts may be strain dependent. This strain dependence may reflect differences in the ability to cope with the intermittent presentation of a stressor, and may explain, at least in part, variability in stress-induced changes in immune functions.
RP SEI, Y (reprint author), NIDDK,NEUROSCI LAB,BETHESDA,MD 20892, USA.
NR 27
TC 5
Z9 5
U1 0
U2 0
PU GORDON BREACH SCI PUBL LTD
PI READING
PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL
SN 0020-7454
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PY 1992
VL 65
IS 1-4
BP 247
EP 258
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA JK646
UT WOS:A1992JK64600027
PM 1341687
ER

PT J
AU EATON, WW
   MENGEL, M
   MENGEL, L
   LARSON, D
   CAMPBELL, R
   MONTAGUE, RB
AF EATON, WW
   MENGEL, M
   MENGEL, L
   LARSON, D
   CAMPBELL, R
   MONTAGUE, RB
TI PSYCHOSOCIAL AND PSYCHOPATHOLOGICAL INFLUENCES ON MANAGEMENT AND CONTROL
   OF INSULIN-DEPENDENT DIABETES
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE HEALTH LOCUS OF CONTROL; DIABETES; DEPRESSION; ANXIETY, ADHERENCE;
   FAMILY COHESION
ID METABOLIC CONTROL; PSYCHIATRIC ASPECTS; GLYCEMIC CONTROL; HEALTH LOCUS;
   MELLITUS; ADOLESCENTS; VARIABLES; ADHERENCE; CHILDREN; IDDM
AB The objective of this research was to explore the relationship of psychosocial variables to management and control of insulin-dependent diabetes, as measured by a scale of reported behavioral adherence and by glycosylated hemoglobin, respectively. The method includes a relatively large sample (127 subjects) drawn from a clinic, a broad range of psychosocial variables (depression, anxiety, family process, health locus of control), and documented reliability and validity of psychosocial measurement (alpha coefficients ranging from .63 to .95). The results show that both anxiety and depression have weak positive correlations with blood sugar. Family process variables also are weakly correlated with blood sugar. The measure of behavioral adherence is moderately correlated with blood sugar. The life stage of the diabetic appears to affect these relationships markedly. The conclusion is that there is no broad strong association of psychosocial variables with blood sugar but that there may be subgroups of diabetics, especially adolescents with recent onset, for whom the relationships may be more powerful.
C1 NIMH,ROCKVILLE,MD 20857.
   SE COUNSELING,CHATTANOOGA,TN.
RP EATON, WW (reprint author), JOHNS HOPKINS UNIV,DEPT MENTAL HYG,624 N BROADWAY,BALTIMORE,MD 21205, USA.
NR 31
TC 37
Z9 38
U1 1
U2 2
PU BAYWOOD PUBL CO INC
PI AMITYVILLE
PA 26 AUSTIN AVE, AMITYVILLE, NY 11701
SN 0091-2174
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 1992
VL 22
IS 2
BP 105
EP 117
PG 13
WC Psychiatry
SC Psychiatry
GA JF249
UT WOS:A1992JF24900001
PM 1517018
ER

PT J
AU YORK, DM
   DARDEN, T
   DEERFIELD, D
   PEDERSEN, LG
AF YORK, DM
   DARDEN, T
   DEERFIELD, D
   PEDERSEN, LG
TI THE INTERACTION OF NA(I), CA(II), AND MG(II) METAL-IONS WITH DUPLEX DNA
   - A THEORETICAL MODELING STUDY
SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
LA English
DT Article; Proceedings Paper
CT 32ND SANIBEL INTERNATIONAL SYMP ON THE APPLICATION OF FUNDAMENTAL THEORY
   TO PROBLEMS OF BIOLOGY AND PHARMACOLOGY
CY MAR 14-21, 1992
CL ST AUGUSTINE, FL
SP USA, RES OFF PHYS, USN, OFF NAVAL RES, US DOE, OFF HLTH & ENV RES, HYPER CHEM, AUTODESK, TEKTRONIX, UNIV FLORIDA, OFF ACAD AFFAIRS
ID MOLECULAR-DYNAMICS; FORCE-FIELD; B-DNA; X-RAY; POLYELECTROLYTE
   SOLUTIONS; DEOXYRIBONUCLEIC-ACID; AQUEOUS-SOLUTIONS; NUCLEIC-ACIDS;
   PHOSPHATE; WATER
AB DNA is a negatively charged biopolymer composed of monomeric nucleotides each carrying on average a net (-1) charge concentrated in the region of the phosphate backbone. In solution, the net negative charge of the molecule is presumably balanced by positively charged cations that interact with the DNA. Important questions arise as to the molecular details of the interaction of different cations with DNA. In this paper, we investigate the interaction of monovalent sodium ions and divalent magnesium and calcium ions with duplex DNA using molecular dynamics. Three 50 ps molecular dynamics simulations of the DNA sequence d[CGCGAATTCGCG]2 have been performed in different ionic environments. Each system is constructed to be electrically neutral and is composed of the DNA duplex immersed in a large water bath containing a specific ionic species [Na(I), Mg(II), or Ca(II)]. The structural differences of the DNA itself as a result of interacting with each ionic species have been previously examined (D. M. York, T. Darden, D. Deerfield, II, and L. Pedersen, J. Biomol. Struct. Dyn., submitted). In the current work, the ion-DNA and ion-water interactions are examined. The coordination shells of the ions and distributions around the phosphate anions are reported, and both show close encouraging agreement with available experimental work. The results of our studies indicate that the hydration state of the ion plays an important role in the direct coordination of the phosphate anions. Na(I) and Ca(II) ions prefer to coordinate the phosphate anions directly, whereas MG(II) ions have a greater tendency to interact with phosphate anions as fully hydrated cations.
C1 NIEHS,MOLEC TOXICOL LAB,RES TRIANGLE PK,NC 27709.
   PITTSBURGH SUPERCOMP CTR,PITTSBURGH,PA 15213.
RP YORK, DM (reprint author), UNIV N CAROLINA,DEPT CHEM,CHAPEL HILL,NC 27514, USA.
RI Pedersen, Lee/E-3405-2013
OI Pedersen, Lee/0000-0003-1262-9861
NR 44
TC 7
Z9 7
U1 0
U2 4
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7608
J9 INT J QUANTUM CHEM
JI Int. J. Quantum Chem.
PY 1992
SU 19
BP 145
EP 166
PG 22
WC Chemistry, Physical; Mathematics, Interdisciplinary Applications;
   Physics, Atomic, Molecular & Chemical
SC Chemistry; Mathematics; Physics
GA JY535
UT WOS:A1992JY53500012
ER

PT J
AU UCKUN, FM
   MITCHELL, JB
   OBUZ, V
   CHANDANLANGLIE, M
   WOO, SM
   HAISSIG, S
   SONG, CW
AF UCKUN, FM
   MITCHELL, JB
   OBUZ, V
   CHANDANLANGLIE, M
   WOO, SM
   HAISSIG, S
   SONG, CW
TI RADIATION AND HEAT SENSITIVITY OF HUMAN T-LINEAGE ACUTE
   LYMPHOBLASTIC-LEUKEMIA (ALL) AND ACUTE MYELOBLASTIC-LEUKEMIA (AML)
   CLONES DISPLAYING MULTIPLE-DRUG RESISTANCE (MDR)
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE MULTIDRUG RESISTANCE; HYPERTHERMIA; RADIATION; LEUKEMIA; CLONOGENIC CELL
ID BONE-MARROW TRANSPLANTATION; PROGENITOR CELLS; ADRIAMYCIN RESISTANCE;
   MONOCLONAL-ANTIBODIES; EXVIVO TREATMENT; HYPERTHERMIA; IMMUNOTOXINS;
   SURVIVAL; CANCER; 4-HYDROPEROXYCYCLOPHOSPHAMIDE
AB The hyperthermia as well as radiation responses of multidrug resistant (CEM/VLB100 with classical MDR and CEM/VM-1 with atypical MDR), methotrexate resistant (CEM/MTX) subclones of CCRF-CEM T-lineage ALL cell line were compared with those of a drug sensitive (CEM-1-3) subclone from the same parent cell line.  Also analyzed were the hyperthermia as well as radiation responses of multidrug resistant (HL60/AR) and drug sensitive subclones of the HL60 AML cell line.  Notably, the drug resistant subclones of CEM and HL60 were as sensitive to hyperthermia as were the drug sensitive subclones.  Importantly, no thermotolerant plateau was observed in the hyperthemia survival curves of the drug resistant subclones, indicating that drug/multidrug resistance is not associated with a greater likelihood of thermal tolerance development during hyperthermia.  Similarly, the drug resistant CEM and HL60 subclones were not more radiation resistant than the drug sensitive subclones.  Thus, the classical or atypical forms of multidrug resistance or methotrexate resistance of the analyzed leukemic cell lines were not associated with radiation resistance.  Furthermore, the radiation survival curves of the drug resistant subclones lacked a distinct initial shoulder and their n values were not greater than those of the drug sensitive subclones, suggesting that multidrug resistance is not associated with an increased ability to repair or accumulate sublethal radiation damage.  Our findings provide evidence that there is no apparent association between drug/multidrug resistance and heat or radiation sensitivity of CEM T-lineage ALL or HL60 AML leukemia cells.  The results of this study indicate that acquired resistance to methotrexate, vinblastine, vincristine, etoposide, actinomycin-D, adriamycin, or daunomycin, or pleiotropic multidrug resistance do not necessarily confer radiation resistance for human leukemic cells.
C1 UNIV MINNESOTA,HLTH SCI CTR,DEPT THERAPEUT RADIOL RADIAT ONCOL,CANC & LEUKEMIA BIOL SECT,MINNEAPOLIS,MN 55455.
   UNIV MINNESOTA,HLTH SCI CTR,DEPT THERAPEUT RADIOL RADIAT ONCOL,RADIAT BIOL SECT,MINNEAPOLIS,MN 55455.
   UNIV MINNESOTA,HLTH SCI CTR,DEPT PEDIAT,DIV HEMATOL ONCOL,BONE MARROW TRANSPLANT PROGRAM,MINNEAPOLIS,MN 55455.
   NCI,RADIAT ONCOL BRANCH,EXPTL PHOTOTHERAPY SECT,BETHESDA,MD 20892.
FU NCI NIH HHS [R29 CA 42111, R01 CA-42633]
NR 55
TC 8
Z9 8
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 23
IS 1
BP 115
EP 125
PG 11
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HR986
UT WOS:A1992HR98600014
PM 1572809
ER

PT J
AU GOFFMAN, TE
   GLATSTEIN, E
AF GOFFMAN, TE
   GLATSTEIN, E
TI CNS LYMPHOMA - BACK TO THE DRAWING BOARD
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Editorial Material
RP GOFFMAN, TE (reprint author), NCI,RADIAT ONCOL BRANCH,B-10,B3B69,BETHESDA,MD 20892, USA.
NR 8
TC 2
Z9 3
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 23
IS 1
BP 247
EP 248
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HR986
UT WOS:A1992HR98600034
PM 1572822
ER

PT J
AU ZOOK, BC
   BRADLEY, EW
   ROGERS, CC
AF ZOOK, BC
   BRADLEY, EW
   ROGERS, CC
TI MORPHOLOGICAL EFFECTS OF FAST-NEUTRONS OR PHOTONS ON THE CANINE KIDNEY
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE DOG; FAST NEUTRONS; PHOTONS; RELATIVE BIOLOGIC EFFECTIVENESS; KIDNEY
ID RENAL DAMAGE; RADIATION NEPHROPATHY; IRRADIATION; PANCREAS; INJURY;
   MOUSE; DOGS; PIG
AB Thirty-nine adult male Beagles received either fast neutron or photon irradiation to the right thorax to determine the relative biological effectiveness of fast neutrons on normal pulmonary tissue. The right anterior abdomen, including the cranial half of the right kidney, was included in the field of irradiation. Twenty-four dogs (six/group) received fast neutrons with an average energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 cGy in four fractions per week for 6 weeks. Fifteen dogs received 3000, 4500, or 6750 cGy of photons (five/group) in an identical fractionation pattern. All 12 neutron irradiated dogs receiving 3375 and 2250 cGy and 1 of 6 receiving 1500 cGy, developed clinical and clinical pathologic signs of hepatic, pancreatic, and gastrointestinal disturbances, but no signs of renal injury were seen. These 13 dogs died or were euthanatized 47-367 days after irradiation. Only 1 of 5 dogs receiving 6750 cGy of photons developed similar signs and died 708 days post-irradiation. The remaining 11 neutron irradiated dogs and 14 photon irradiated dogs eventually died of other causes. All 39 dogs were necropsied and their kidneys were compared to each other and to control dogs. Radiation induced lesions included hemorrhages, necrosis and disappearance of tubular epithelia, glomerulosclerosis, atrophy and fibrosis. These lesions were associated with degenerative and occlusive vascular changes and were much more severe in the neutron irradiated dogs. The relative biologic effectiveness of fast neutrons for canine kidney assessed by gross and microscopic pathology is approximately 4.5 (6750/1500).
C1 GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,WASHINGTON,DC 20037.
   NIH,DIV RES GRANTS,BETHESDA,MD 20892.
RP ZOOK, BC (reprint author), GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,2300 I ST NW,WASHINGTON,DC 20037, USA.
FU NCI NIH HHS [1-R01-CA-18143]
NR 56
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 23
IS 4
BP 821
EP 830
PG 10
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA JD828
UT WOS:A1992JD82800015
PM 1618674
ER

PT J
AU PIERCE, LJ
   LIPPMAN, M
   BENBARUCH, N
   SWAIN, S
   OSHAUGHNESSY, J
   BADER, JL
   DANFORTH, D
   VENZON, D
   COWAN, KH
AF PIERCE, LJ
   LIPPMAN, M
   BENBARUCH, N
   SWAIN, S
   OSHAUGHNESSY, J
   BADER, JL
   DANFORTH, D
   VENZON, D
   COWAN, KH
TI THE EFFECT OF SYSTEMIC THERAPY ON LOCAL-REGIONAL CONTROL IN LOCALLY
   ADVANCED BREAST-CANCER
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article; Proceedings Paper
CT 33RD ANNUAL MEETING OF THE AMERICAN SOC FOR THERAPEUTIC RADIOLOGY AND
   ONCOLOGY
CY NOV, 1991
CL WASHINGTON, DC
SP AMER SOC THERAPEUT RADIOL & ONCOL
DE BREAST CANCER; LOCALLY ADVANCED; RADIATION THERAPY; LOCAL-REGIONAL
   CONTROL
ID COMBINED MODALITY APPROACH; PRIMARY RADIATION-THERAPY; STAGE-III;
   INFLAMMATORY CARCINOMA; RADICAL RADIOTHERAPY; PRIMARY CHEMOTHERAPY;
   COMBINATION CHEMOTHERAPY; NEOADJUVANT CHEMOTHERAPY; ADJUVANT
   CHEMOTHERAPY; CONSERVATIVE SURGERY
AB One hundred and seven patients with locally advanced breast cancer were prospectively referred for multimodality treatment on protocol using chemohormonal therapy to maximal response followed by local treatment and maintenance therapy. Forty-eight patients (45%) were diagnosed with Stage IIIA disease, 46 (43%) with Stage IIIB inflammatory cancer, and 13 (12%) with Stage IIIB non-inflammatory disease. Induction therapy consisted of cyclophosphamide, doxorubicin, methotrexate, and 5-fluorouracil with hormonal synchronization using tamoxifen and conjugated estrogens. Local treatment was determined by response to chemotherapy. Patients with a clinical partial response underwent mastectomy followed by local-regional radiotherapy while patients with a clinical complete response were biopsied for pathologic correlation. Those with residual disease received mastectomy followed by radiotherapy while those with a pathologic complete response received radiation only to the intact breast and regional nodes. With a median follow-up of 64 months, patients with IIIA disease had a significantly lower local-regional failure rate compared to IIIB inflammatory patients, with the 5-year actuarial local-regional failure rate as only site of first failure 3% for IIIA disease versus 21% for IIIB inflammatory cancer (p = .02), and local-regional failure as any component of first failure 12% versus 36% (p = .01), respectively. When local-regional failure was analyzed by repeat biopsy, 5/31 (16%) patients with a pathologic complete response treated with radiation only developed a local-regional failure versus 2/53 (4%) with residual disease treated with mastectomy and postoperative radiotherapy. The 5-year actuarial local-regional failure rate as first site of failure was 23% for radiation only versus 5% for mastectomy and post-operative radiotherapy (p = .07). The response to chemotherapy did not reliably predict local-regional control. Both relapse-free survival and overall survival were significantly better for IIIA versus IIIB patients; stratification by repeat biopsy did not, however, significantly affect either relapse-free or overall survival.
C1 NCI,MED BRANCH,BETHESDA,MD 20892.
   NCI,SURG BRANCH,BETHESDA,MD 20892.
   NCI,BIOSTAT & DATA MANAGEMENT SECT,BETHESDA,MD 20892.
   GEORGETOWN UNIV,VINCENT T LOMBARDI CANC RES CTR,WASHINGTON,DC 20007.
RP PIERCE, LJ (reprint author), NCI,RADIAT ONCOL BRANCH,BLDG 10,B3B69,BETHESDA,MD 20892, USA.
RI Venzon, David/B-3078-2008
NR 57
TC 57
Z9 57
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 23
IS 5
BP 949
EP 960
PG 12
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA JG301
UT WOS:A1992JG30100007
PM 1639655
ER

PT J
AU PIERCE, L
   COWAN, K
   GLATSTEIN, E
   LIPPMAN, M
AF PIERCE, L
   COWAN, K
   GLATSTEIN, E
   LIPPMAN, M
TI LOCAL-CONTROL FOR LOCALLY ADVANCED BREAST-CANCER - MANY OPINIONS, FEW
   FACTS - RESPONSE
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Letter
ID PRIMARY CHEMOTHERAPY
C1 GEORGETOWN UNIV,MED CTR,VINCENT T LOMBARDI CANC RES CTR,WASHINGTON,DC 20007.
RP PIERCE, L (reprint author), NCI,BETHESDA,MD 20892, USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 23
IS 5
BP 1093
EP 1093
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA JG301
UT WOS:A1992JG30100029
ER

PT J
AU TOCHNER, ZA
   PASS, HI
   SINDELAR, WF
   DELUCA, AM
   GRISELL, DL
   BACHER, JD
   KINSELLA, TJ
AF TOCHNER, ZA
   PASS, HI
   SINDELAR, WF
   DELUCA, AM
   GRISELL, DL
   BACHER, JD
   KINSELLA, TJ
TI LONG-TERM TOLERANCE OF THORACIC ORGANS TO INTRAOPERATIVE RADIOTHERAPY
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE INTRAOPERATIVE IRRADIATION; CARCINOMA OF LUNG; LATE EFFECTS; NORMAL
   TISSUE TOLERANCE
ID EXTERNAL BEAM IRRADIATION; RADIATION-THERAPY; CARCINOMA; CANCER; IORT
AB The tolerance of mediastinal structures to intraoperative radiotherapy (IORT) was investigated in 3 separate animal trials using 49 adult foxhounds and one limited Phase I trial in 4 patients with Stage II or III non-small cell lung cancer (NSCLC).  The 1- to 2-year results of these trials have been previously reported with significant toxicity found at dose levels over 20 Gy.  We now report the results of five dogs reserved for long term studies and one Stage II NSCLC patient alive at 5 years.  Two dogs received 20 Gy IORT and one received 30 Gy IORT to the esophagus, all three to a single 6 cm field with 9 MeV electrons.  One control dog underwent surgery without irradiation.  One dog received 20 Gy IORT to a single 5 cm mediastinal field with 13 MeV electrons following left pneumonectomy.  At 5 years, all five dogs reserved for a long term evaluation were alive and evaluable with minimal endoscopic and radiographic abnormalities.  The one patient alive at 5 years for evaluation received 25 Gy IORT to two matched 6 cm fields with 13 MeV electrons.  She has stable dyspnea on exertion and there is no evidence of cancer by endoscopy.  We conclude, based on these limited data, that IORT in the mediastinum may be safe at dose levels that do not exceed 20 Gy, and further careful evaluation at these lower treatment doses is warranted to determine efficacy.
C1 NCI,RADIAT ONCOL BRANCH,BLDG 10,ROOM B3B69,9000 ROCKVILLE PIKE,BETHESDA,MD 20892.
   NCI,SURG BRANCH,BETHESDA,MD 20892.
   NIH,DIV RES SERV,VET RESOURCES BRANCH,BETHESDA,MD 20892.
   UNIV WISCONSIN,DEPT HUMAN ONCOL,CTR CLIN CANC,MADISON,WI 53706.
NR 17
TC 10
Z9 10
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 1
BP 65
EP 69
PG 5
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA GU932
UT WOS:A1992GU93200009
PM 1309205
ER

PT J
AU STONE, HB
   MINCHINTON, AI
   LEMMON, M
   MENKE, D
   BROWN, JM
AF STONE, HB
   MINCHINTON, AI
   LEMMON, M
   MENKE, D
   BROWN, JM
TI PHARMACOLOGICAL MODIFICATION OF TUMOR BLOOD-FLOW - LACK OF CORRELATION
   BETWEEN ALTERATION OF MEAN ARTERIAL BLOOD-PRESSURE AND CHANGES IN TUMOR
   PERFUSION
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE FLAVONE ACETIC ACID; HYDRALAZINE; NICOTINAMIDE; MEAN ARTERIAL BLOOD
   PRESSURE; TUMOR PERFUSION; TUMORS
ID FLAVONE ACETIC-ACID; MAGNETIC-RESONANCE SPECTROSCOPY; CYTO-TOXICITY;
   MURINE TUMOR; VASCULAR-RESISTANCE; RADIATION RESPONSE;
   ENERGY-METABOLISM; VASOACTIVE DRUGS; BEARING RATS; HYDRALAZINE
AB The correlation between mean arterial blood pressure (MABP) and vascular perfusion in SCC-VII/St tumors in mice was compared following administration of three vasoactive drugs:  flavone acetic acid (200 mg/kg), hybralazine (5 mg/kg), or nicotinamide (500, 750, and 1000 mg/kg).  MABP was measured by the direct method in unanesthetized, unrestrained mice bearing a carotid catheter.  Vascular perfusion of the tumor was measured using the (RbCl)-Rb-86 extraction method.  Body temperature was maintained at 36-degrees to 37-degrees-C after drug administration when necessary.  All three drugs reduced MABP from a control value of 125 +/- 2 (s.e.) mm Hg in mice without tumors.  Flavone acetic acid at this dose had the least effect on blood pressure, with a minimum of 86% of control values at 10 to 20 min, and a return to control values by 1 hr.  However, it produced a profound reduction in tumor perfusion that lasted more than 48 hr.  Hydralazine and nicotinamide reduced blood pressure to minima between 55% and 69% of control values within 30 min, followed by a gradual return toward control values by about 8 hr.  The reduction in tumor perfusion by hydralazine paralleled its effect on blood pressure.  However, nicotinamide produced a transitory, although not statistically significant, increase in tumor perfusion at the highest dose given.  These data demonstrate that tumor blood flow modification by drugs is not necessarily the result of changes in MABP, and blood pressure changes alone do not inevitably lead to changes in tumor perfusion.
C1 STANFORD UNIV,DEPT RADIAT ONCOL,DIV RADIAT BIOL,STANFORD,CA 94305.
RP STONE, HB (reprint author), NCI,EPN 800,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
FU NCI NIH HHS [CA 25990]
NR 69
TC 14
Z9 14
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 1
BP 79
EP 86
PG 8
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA GU932
UT WOS:A1992GU93200011
PM 1530755
ER

PT J
AU MILLER, RW
   ORR, K
   GOFFMAN, TE
   HARRINGTON, FS
   VANDEGEIJN, J
   GLATSTEIN, E
AF MILLER, RW
   ORR, K
   GOFFMAN, TE
   HARRINGTON, FS
   VANDEGEIJN, J
   GLATSTEIN, E
TI A SIMPLE CT APERTURE EMULATOR FOR USE WITH A RADIOTHERAPY SIMULATOR
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Note
DE RADIOTHERAPY; TREATMENT PLANNING; COMPUTER-ASSISTED; IMAGE CORRELATION;
   TOMOGRAPHY-X-RAY COMPUTED; TOMOGRAPHY-EMISSION COMPUTED
AB Tumor localization in radiation treatment planning often involves the generation of quantitative anatomical data from multiple imaging modalities.  It is desirable to take all of the images in the selected treatment position, which is usually decided upon during the initial simulator session.  The different scanning modalities are often operated by different staff, at different times and in different locations; thus, it is difficult to ensure consistency in the position of the patient's body, and its documentation, at various times and places.  Also, devices such as CT and MR scanners frequently pose restrictions due to their limited apertures.  Failure to consider the physical limitations of such scanning equipment at the time of simulation or localization may result in placing the patient in a treatment position which will not fit through the aperture of the CT (or MRI) scanner, or which will result in a clinically important portion of the anatomy being " cut off" in the resulting scans.  This can lead to re-simulation of the patient or result in a lack of accurate coordination of simulator and CT scan data.  To minimize problems such as these, we have developed a CT Aperture Emulator which can be used at the time of the initial simulation.  This is a lightweight "halo" easily attached to the simulator, which  mimics the size and shape of the CT aperture.  It permits reproducible adjustment of the patient's position, while allowing technologists and physicians to set up the patient with respect to potential CT constraints, in particular with regard to the use of immobilization and support devices.  The emulator device also facilitates reproducing a patient's treatment position on the CT scanner.  The concept has been found to have additional clinical uses and can be extended to a variety of imaging equipment.
RP MILLER, RW (reprint author), NCI,DCT,COP,RADIAT ONCOL BRANCH,BETHESDA,MD 20892, USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 1
BP 195
EP 198
PG 4
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA GU932
UT WOS:A1992GU93200026
PM 1727118
ER

PT J
AU MITCHELL, JB
   COLEMAN, CN
AF MITCHELL, JB
   COLEMAN, CN
TI BIOCHEMICAL MODIFICATION OF THERAPEUTIC RESPONSE
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Editorial Material
C1 JOINT CTR RADIAT THERAPY,BOSTON,MA 02115.
RP MITCHELL, JB (reprint author), NCI,RADIAT ONCOL BRANCH,BETHESDA,MD 20892, USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 3
BP 483
EP 484
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HC863
UT WOS:A1992HC86300021
PM 1735683
ER

PT J
AU GARG, PK
   GARG, S
   DEGRAFF, WG
   ZALUTSKY, MR
   MITCHELL, JB
AF GARG, PK
   GARG, S
   DEGRAFF, WG
   ZALUTSKY, MR
   MITCHELL, JB
TI 4-FLUOROBENZYLAMINE AND PHENYLALANINE METHYL-ESTER CONJUGATES OF
   2-NITROIMIDAZOLE - EVALUATION AS HYPOXIC CELL RADIOSENSITIZERS
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article; Proceedings Paper
CT 7TH INTERNATIONAL CONF ON CHEMICAL MODIFIERS OF CANCER TREATMENT
CY FEB 02-05, 1991
CL CLEARWATER, FL
SP DUPONT CO, LEDERLE LAB, ROBERTS PHARM, US BIOSCI
DE 2-NITROIMIDAZOLE; BSO; SR-2508; HYPOXIC CELL SENSITIZER; FLUORINATED
   2-NITROIMIDAZOLE; AMINO ACID ANALOG
ID PHASE-I TRIAL; SR-2508 ETANIDAZOLE; AMINO-ACIDS; SENSITIZATION; ANALOGS;
   INVIVO
AB We have synthesized two 2-nitroimidazole derivatives and evaluated their hypoxic radiosensitization properties. The first, a 4-fluorobenzylamine conjugate of 2-nitroimidazole (PK-110), was designed so that it could also be labeled with the F-18 and used for positron emission tomographic imaging of hypoxia. The second, the L-phenylalanine methyl ester conjugate of 2-nitroimidazole (PK-130), was designed in an attempt to exploit amino acid transport channels to enhance drug transport into the tumor. The effects of these drugs (and SR-2508, for comparison) in vitro on the aerobic and hypoxic radiosensitivity of Chinese hamster V79 cells were evaluated using clonogenic assays. PK-130 and PK-110 at 0.1 and 1.0 mM were more efficient hypoxic cell radiosensitizers than SR-2508 at the same concentrations. PK-130 and PK-110 at 0.1 mM yielded comparable SER's to that obtained with 1.0 mM SR-2508. Marginal aerobic radiosensitization was observed for 1.0 mM treatment with PK-130 and PK-110, however, no aerobic radiosensitization was observed at 0.1 mM. Glutathione (GSH) depletion (< 5% of control levels) by L-buthionine sulfoximine (BSO) further enhanced the SER for both PK-130 and PK-110 at 0.1 mM to 3.2 +/- 0.63 and 2.4 +/- 0.16, respectively. The results of this study encourage the in vivo tumor radiosensitization evaluation of PK-130 and PK-110.
C1 NCI,RADIAT BIOL SECT,RADIAT ONCOL BRANCH,BETHESDA,MD 20892.
RP GARG, PK (reprint author), DUKE UNIV,MED CTR,DEPT RADIOL,BOX 3808,DURHAM,NC 27710, USA.
NR 19
TC 5
Z9 5
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 3
BP 593
EP 596
PG 4
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HC863
UT WOS:A1992HC86300047
PM 1531220
ER

PT J
AU BIAGLOW, JE
   MITCHELL, JB
   HELD, K
AF BIAGLOW, JE
   MITCHELL, JB
   HELD, K
TI THE IMPORTANCE OF PEROXIDE AND SUPEROXIDE IN THE X-RAY RESPONSE
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article; Proceedings Paper
CT 7TH INTERNATIONAL CONF ON CHEMICAL MODIFIERS OF CANCER TREATMENT
CY FEB 02-05, 1991
CL CLEARWATER, FL
DE PEROXIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE;
   GLUTATHIONE-S-TRANSFERASE; A549 HUMAN CARCINOMA; RADIATION LETHALITY;
   HYDROPEROXIDES; PEROXIDE ELECTRODE
ID LUNG CARCINOMA-CELLS; AEROBIC RADIATION RESPONSE; BUTHIONINE
   SULFOXIMINE; DIETHYL MALEATE; MAMMALIAN-CELLS; DEPLETION; GLUTATHIONE;
   ENHANCEMENT; METABOLISM
AB Radiation produces a number of damaging radicals as well as peroxide. The chief cellular protection against these radicals, their secondary reactants and peroxide is the cellular glutathione (GSH), GSH peroxidase, GSH-S-transferase (GSHTase), and catalase enzymes. Inhibition of cellular catalase alone does not enhance the aerobic radiation response because cellular GSH peroxidase is equally effective in reducing peroxide. However, inhibition of GSHTase, and partial inhibition of peroxidase by L-buthionine sulfoximine (LBSO)-linked GSH depletion, results in an increased aerobic radiation response. The major pathway for peroxide reduction is the GSH peroxidase. The enzyme is accountable for 70% inactivation of low peroxide concentrations. Catalase accounts for the remaining inactivation. However, it is difficult to assess the relative contributions of GSHTase and peroxidase to the inactivation of radiation-produced hydroperoxides. Our data suggest that GSH depletion results in the inhibition of cellular GSHTase before it inhibits GSH peroxidase. Therefore, part of the increased aerobic radiation response maybe due to cellular inability to reduce hydroperoxides. Peroxide is not a substrate for GSHTase. However, total inhibition of peroxidase by L-BSO plus N-ethylmaleimide (NEM) treatment maximizes the aerobic radiation response. Total inhibition of GSH-S-transferase and peroxidase would block both peroxide and hydroperoxide reduction.
C1 NCI,BETHESDA,MD 20892.
   HARVARD UNIV,BOSTON,MA 02115.
RP BIAGLOW, JE (reprint author), UNIV PENN,DEPT RADIAT ONCOL,195 JOHN MORGAN BLDG,37TH,HAMILTON WALK,PHILADELPHIA,PA 19104, USA.
FU NCI NIH HHS [CA-44982]
NR 18
TC 56
Z9 56
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 4
BP 665
EP 669
PG 5
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HJ377
UT WOS:A1992HJ37700008
PM 1312073
ER

PT J
AU TUTTLE, SW
   VARNES, ME
   MITCHELL, JB
   BIAGLOW, JE
AF TUTTLE, SW
   VARNES, ME
   MITCHELL, JB
   BIAGLOW, JE
TI SENSITIVITY TO CHEMICAL OXIDANTS AND RADIATION IN CHO CELL-LINES
   DEFICIENT IN OXIDATIVE PENTOSE CYCLE ACTIVITY
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article; Proceedings Paper
CT 7TH INTERNATIONAL CONF ON CHEMICAL MODIFIERS OF CANCER TREATMENT
CY FEB 02-05, 1991
CL CLEARWATER, FL
DE PENTOSE CYCLE; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; GLUTATHIONE
   HYDROPEROXIDES; DIAMIDE; IONIZING RADIATION
ID HEXOSE-MONOPHOSPHATE SHUNT; METABOLISM; COLONIES
AB In this paper we examine the susceptibility of a series of G6PD- CHO cell lines to a variety of chemical oxidants. Addition of these drugs to K1D, the parental cell line, results in as much as a 20-fold increase in pentose cycle (PC) activity over control values. In two of our mutant lines, E16 and E48, little or no stimulation of PC activity is seen. These lines are shown to be much more susceptible to the toxic effects of the chemical oxidants t-butyl hydroperoxide and diamide. PC activity is also stimulated by ionizing radiation in K1D cells. One of the G6PD- cell lines has an increased aerobic radiation response compared to the parental line. However, since this is not the case with the other G6PD- cell lines, it is unclear whether this represents a difference in the absolute value of PC activity or some additional variable that may be influencing the results.
C1 CASE WESTERN RESERVE UNIV,DEPT RADIAT ONCOL,CLEVELAND,OH 44106.
   NCI,DEPT RADIAT BIOL,BETHESDA,MD 20892.
RP TUTTLE, SW (reprint author), UNIV PENN,SCH MED,DEPT RADIAT ONCOL,195 JOHN MORGAN BLDG,37TH,HAMILTON WALK,PHILADELPHIA,PA 19104, USA.
FU NCI NIH HHS [CA-44982]
NR 16
TC 64
Z9 64
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 4
BP 671
EP 675
PG 5
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HJ377
UT WOS:A1992HJ37700009
PM 1544835
ER

PT J
AU GOFFMAN, T
   CUSCELA, D
   GLASS, J
   HAHN, S
   KRISHNA, CM
   LUPTON, G
   MITCHELL, JB
AF GOFFMAN, T
   CUSCELA, D
   GLASS, J
   HAHN, S
   KRISHNA, CM
   LUPTON, G
   MITCHELL, JB
TI TOPICAL APPLICATION OF NITROXIDE PROTECTS RADIATION-INDUCED ALOPECIA IN
   GUINEA-PIGS
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE RADIOPROTECTION; ALOPECIA; NITROXIDE; OXIDATIVE STRESS; ELECTRON SPIN
   RESONANCE
AB We have recently found that treatment of Chinese hamster V79 cells with the stable nitroxide radical TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) afforded significant protection against superoxide, hydrogen peroxide, and X-ray mediated cytotoxicity. Radiation-induced alopecia is a common radiotherapeutic problem. Topical application of TEMPOL was evaluated for possible protective effects against radiation-induced alopecia using guinea pig skin as a model. For single acute X-ray doses up to 30 Gy, TEMPOL, when topically applied 15 min prior to irradiation provided a marked increase in the rate and extent of new hair recovery when compared to untreated skin. TEMPOL was detected in treated skin specimens with electron paramagnetic resonance (EPR) spectroscopy. Similar measurements of blood samples failed to show any signal resulting from topical application, nor could TEMPOL be detected in brain tissue after application on the scalp. TEMPOL represents a new class of compounds with potential for selective cutaneous radioprotection without systemic absorption.
C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306.
RP GOFFMAN, T (reprint author), NCI,RADIAT ONCOL BRANCH,BLDG 10,B3-B69,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 7
TC 41
Z9 42
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 1992
VL 22
IS 4
BP 803
EP 806
PG 4
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA HJ377
UT WOS:A1992HJ37700037
PM 1544853
ER

PT J
AU HARRISON, LD
AF HARRISON, LD
TI TRENDS IN ILLICIT DRUG-USE IN THE UNITED-STATES - CONFLICTING RESULTS
   FROM NATIONAL SURVEYS
SO INTERNATIONAL JOURNAL OF THE ADDICTIONS
LA English
DT Article
DE DRUG; TREND; SURVEY; COCAINE; CRIMINAL
AB Data from several national studies lead to divergent conclusions regarding trends in illicit drug use in the United States. Two major population studies point to a downturn in drug use dating to the late 1970s. However, a study of drug-related deaths and hospital emergency room visits shows increases in these events in recent years. Studies also show drug use, especially cocaine, continuing to increase among criminals. Additionally, drugs were identified as the most important problem facing the nation in a Gallup poll conducted during the summer of 1989. This paper offers some possible explanations for the divergent trends. Most notably, we suggest that methodological differences in the studies being compared, and lags between trends in the general population and certain subgroups, account for most of the variation in the trend estimates. The paper concludes that illicit drug use is decreasing in the United States.
C1 NATL INST JUSTICE,WASHINGTON,DC.
RP HARRISON, LD (reprint author), NIDA,NATL HOUSEHOLD SURVEY DRUG ABUSE,5600 FISHERS LANE,ROCKWALL 2 BLDG,SUITE 615,ROCKVILLE,MD 20857, USA.
NR 35
TC 32
Z9 32
U1 1
U2 2
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0020-773X
J9 INT J ADDICT
JI Int. J. Addict.
PY 1992
VL 27
IS 7
BP 817
EP 847
PG 31
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA HZ019
UT WOS:A1992HZ01900003
PM 1618584
ER

PT J
AU KOLAR, AF
   BROWN, BS
   WEDDINGTON, WW
   HAERTZEN, CC
   MICHAELSON, BS
   JAFFE, JH
AF KOLAR, AF
   BROWN, BS
   WEDDINGTON, WW
   HAERTZEN, CC
   MICHAELSON, BS
   JAFFE, JH
TI TREATMENT OF COCAINE DEPENDENCE IN METHADONE-MAINTENANCE CLIENTS - A
   PILOT-STUDY COMPARING THE EFFICACY OF DESIPRAMINE AND AMANTADINE
SO INTERNATIONAL JOURNAL OF THE ADDICTIONS
LA English
DT Article
ID INTRAVENOUS DRUG-USERS; INFECTION; ABUSE
AB We conducted a pilot study (N = 22). comparing the efficacy of desipramine and amantadine for treatment of cocaine dependence in methadone maintenance clients. The study which lasted 12 weeks, was double-blind, randomly assigned, and placebo-controlled. Subjects met DSM-III-R criteria for active cocaine dependence. All three groups' cocaine use, craving, and depressive symptoms declined significantly, but intergroup differences were not significant. Clients receiving desipramine were significantly more likely to remain in treatment and to be cocaine free at study completion. The results emphasize the importance of delivering comprehensive services to the cocaine user in methadone treatment. Further evaluations of these two medications as adjuncts in the treatment of cocaine dependence are needed.
C1 NIDA,ADDICT RES CTR,BALTIMORE,MD.
NR 23
TC 22
Z9 22
U1 1
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0020-773X
J9 INT J ADDICT
JI Int. J. Addict.
PY 1992
VL 27
IS 7
BP 849
EP 868
PG 20
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA HZ019
UT WOS:A1992HZ01900004
PM 1319961
ER

PT J
AU MAGRUDERHABIB, K
   HUBBARD, RL
   GINZBURG, HM
AF MAGRUDERHABIB, K
   HUBBARD, RL
   GINZBURG, HM
TI EFFECTS OF DRUG MISUSE TREATMENT ON SYMPTOMS OF DEPRESSION AND SUICIDE
SO INTERNATIONAL JOURNAL OF THE ADDICTIONS
LA English
DT Article
ID FOLLOW-UP; PSYCHIATRIC-DISORDERS; OPIOID ADDICTS; DEATH RATES;
   COMMUNITY; ABUSE; VALIDATION; ALCOHOLICS
AB In this longitudinal study of 9,904 clients who were treated at methadone, outpatient drug-free (OPDF), and residential treatment facilities, at intake more than half of all clients reported symptoms of depression or suicide. Females and multiple nonnarcotics users were at highest risk for suicide attempts. Despite a dramatic drop in the level of symptomatology by 4 weeks in treatment, many clients remained suicidal throughout the study period. Suicidal tendencies at both intake and 4 weeks were strongly related to suicidal tendencies at 12 months posttreatment; even more strongly related was the return to weekly or more frequent use of narcotics or nonnarcotics for residential and OPDF clients.
C1 RES TRIANGLE INST,CTR SOCIAL RES & POLICY ANAL,POB 12194,RES TRIANGLE PK,NC 27709.
   NIMH,DIV APPL & SERV RES,BETHESDA,MD 20892.
   HLTH RESOURCES & SERV ADM,BUR HLTH CARE DELIVERY & ASSISTANCE,BETHESDA,MD.
NR 57
TC 6
Z9 6
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0020-773X
J9 INT J ADDICT
JI Int. J. Addict.
PY 1992
VL 27
IS 9
BP 1035
EP 1065
PG 31
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA JL914
UT WOS:A1992JL91400002
PM 1328075
ER

PT J
AU LEUKEFELD, C
   PICKENS, RW
   SCHUSTER, CR
AF LEUKEFELD, C
   PICKENS, RW
   SCHUSTER, CR
TI RECOMMENDATIONS FOR IMPROVING DRUG-TREATMENT
SO INTERNATIONAL JOURNAL OF THE ADDICTIONS
LA English
DT Article
DE DRUG TREATMENT; TREATMENT IMPROVEMENT; TREATMENT RECOMMENDATIONS
ID ABUSE
AB Recognizing that drug use is both chronic and relapsing once an individual is addicted, and that treatment is effective in reducing drug use/misuse, improving drug misuse treatment is examined and research as well as practice recommendations are presented. Drug misuse treatment is now recognized in the United States to meet the expanding drug use problem and for reducing the spread of HIV. With that background, the current status of drug misuse treatment is reviewed, clinical issues are emphasized, and policy issues are noted. Recommendations include the need for uniform funding, linkage with community agencies, technology transfer, training, and expanding research and evaluation efforts.
C1 NIDA,ROCKVILLE,MD.
   UNIV KENTUCKY,CTR DRUG & ALCOHOL RES,LEXINGTON,KY 40506.
   NIDA,ADDICT RES CTR,BALTIMORE,MD.
NR 37
TC 8
Z9 8
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0020-773X
J9 INT J ADDICT
JI Int. J. Addict.
PY 1992
VL 27
IS 10
BP 1223
EP 1239
PG 17
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA JQ294
UT WOS:A1992JQ29400008
PM 1399162
ER

PT J
AU IZUNO, T
   MIYAKAWA, M
   TSUNODA, T
   PARRISH, KM
   KONO, H
   OGATA, M
   HARFORD, TC
   TOWLE, LH
AF IZUNO, T
   MIYAKAWA, M
   TSUNODA, T
   PARRISH, KM
   KONO, H
   OGATA, M
   HARFORD, TC
   TOWLE, LH
TI ALCOHOL-RELATED PROBLEMS ENCOUNTERED BY JAPANESE, CAUCASIANS, AND
   JAPANESE-AMERICANS
SO INTERNATIONAL JOURNAL OF THE ADDICTIONS
LA English
DT Article
AB Using population-based survey data, personal-problematic and socioproblematic factors were examined among Japanese in Japan, Japanese-Americans in Hawaii, and Japanese-Americans; Caucasians in California were analyzed as a control group. Caucasian males were more likely to exhibit drinking-related social problems, whereas Japanese males showed more personal-problematic symptoms. Japanese-American men, both in Hawaii and California, were least likely among the three ethnic groups to have personal-problematic symptoms and were more likely to have socioproblematic symptoms than Japanese men. These differences might be explained by differences in the perception of social problems.
C1 KYORIN UNIV,SCH MED,DEPT HYG,MITAKA,TOKYO 181,JAPAN.
   SAPPORO MED COLL,NATL INST ALCOHOLISM,SAPPORO,HOKKAIDO 060,JAPAN.
   NIAAA,ROCKVILLE,MD 20852.
   UNIV WASHINGTON,DEPT HLTH SERV,SEATTLE,WA 98195.
   KURIHAMA NATL HOSP,NATL INST ALCOHOLISM,KANAGAWA,JAPAN.
RP IZUNO, T (reprint author), KEIO UNIV,SCH MED,DEPT PREVENT MED & PUBL HLTH,35 SHINANOMACHI,SHINJUKU KU,TOKYO 160,JAPAN.
OI Makimoto, Kiyoko/0000-0003-0242-1290
NR 15
TC 3
Z9 4
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0020-773X
J9 INT J ADDICT
JI Int. J. Addict.
PY 1992
VL 27
IS 12
BP 1389
EP 1400
PG 12
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA JX565
UT WOS:A1992JX56500002
PM 1452390
ER

PT J
AU FIELDS, RD
   NELSON, PG
AF FIELDS, RD
   NELSON, PG
TI ACTIVITY-DEPENDENT DEVELOPMENT OF THE VERTEBRATE NERVOUS-SYSTEM
SO INTERNATIONAL REVIEW OF NEUROBIOLOGY
LA English
DT Review
ID LONG-TERM POTENTIATION; PROTEIN-KINASE-C; METHYL-D-ASPARTATE; KITTEN
   VISUAL-CORTEX; MICROTUBULE-ASSOCIATED PROTEINS; OCULAR-DOMINANCE
   COLUMNS; FROG NEUROMUSCULAR-JUNCTIONS; RETINAL GANGLION-CELLS;
   CALMODULIN-BINDING-PROTEIN; EXCITATORY AMINO-ACIDS
RP NICHHD, DEV NEUROBIOL LAB, BETHESDA, MD 20892 USA.
NR 575
TC 94
Z9 95
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 1992
VL 34
BP 133
EP 214
PG 82
WC Neurosciences
SC Neurosciences & Neurology
GA MD553
UT WOS:A1992MD55300003
PM 1587715
ER

PT J
AU WEIGHT, FF
AF WEIGHT, FF
TI CELLULAR AND MOLECULAR PHYSIOLOGY OF ALCOHOL ACTIONS IN THE
   NERVOUS-SYSTEM
SO INTERNATIONAL REVIEW OF NEUROBIOLOGY
LA English
DT Review
ID GAMMA-AMINOBUTYRIC ACID; SPINAL-CORD NEURONS; CEREBELLAR PURKINJE
   NEURONS; LOCUS COERULEUS NEURONS; NICOTINIC ACETYLCHOLINE-RECEPTOR;
   BENZODIAZEPINE INVERSE AGONISTS; EARLY POTASSIUM CURRENTS;
   GENERAL-ANESTHETICS ACT; VENTRAL TEGMENTAL AREA; EXCITATORY AMINO-ACIDS
RP WEIGHT, FF (reprint author), NATL INST ALCOHOL ABUSE & ALCOHOLISM, MOLEC & CELLULAR NEUROBIOL LAB, ROCKVILLE, MD 20852 USA.
NR 249
TC 65
Z9 67
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 1992
VL 33
BP 289
EP 348
DI 10.1016/S0074-7742(08)60694-7
PG 60
WC Neurosciences
SC Neurosciences & Neurology
GA MD552
UT WOS:A1992MD55200005
PM 1592568
ER

PT B
AU MORGAN, RA
   ANDERSON, WF
AF MORGAN, RA
   ANDERSON, WF
GP INT ASSOC BIOL STANDARDIZAT
TI PCR AND OTHER TEST SYSTEMS IN HUMAN GENE-THERAPY
SO INTERNATIONAL SYMPOSIUM ON CONTINUOUS CELL LINES - AN INTERNATIONAL
   WORKSHOP ON CURRENT ISSUES
SE DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION
LA English
DT Proceedings Paper
CT INTERNATIONAL SYMP ON CONTINUOUS CELL LINES
CY MAR 20-22, 1991
CL NIH CAMPUS, BETHESDA, MD
SP US FDA, CTR BIOL EVALUAT & RES, NIAID, NATL VACCINE PROGRAM OFF, WHO
HO NIH CAMPUS
RP MORGAN, RA (reprint author), NHLBI,MOLEC HEMATOL BRANCH,BETHESDA,MD 20892, USA.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5618-7
J9 DEV BIOLOGICALS
JI Dev. Biols
PY 1992
VL 76
BP 171
EP 177
PG 7
WC Biology; Immunology
SC Life Sciences & Biomedicine - Other Topics; Immunology
GA BW99W
UT WOS:A1992BW99W00020
PM 1478336
ER

PT B
AU HARTLEY, JW
AF HARTLEY, JW
GP INT ASSOC BIOL STANDARDIZAT
TI DETECTION OF MURINE LEUKEMIA VIRUSES - INVITRO INFECTIVITY TESTS
SO INTERNATIONAL SYMPOSIUM ON CONTINUOUS CELL LINES - AN INTERNATIONAL
   WORKSHOP ON CURRENT ISSUES
SE DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION
LA English
DT Proceedings Paper
CT INTERNATIONAL SYMP ON CONTINUOUS CELL LINES
CY MAR 20-22, 1991
CL NIH CAMPUS, BETHESDA, MD
SP US FDA, CTR BIOL EVALUAT & RES, NIAID, NATL VACCINE PROGRAM OFF, WHO
HO NIH CAMPUS
RP HARTLEY, JW (reprint author), NIAID,VIRAL ONCOL SECT,BLDG 7,ROOM 302,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5618-7
J9 DEV BIOLOGICALS
JI Dev. Biols
PY 1992
VL 76
BP 179
EP 186
PG 8
WC Biology; Immunology
SC Life Sciences & Biomedicine - Other Topics; Immunology
GA BW99W
UT WOS:A1992BW99W00021
PM 1335932
ER

PT B
AU FRENKEL, N
   WYATT, LS
AF FRENKEL, N
   WYATT, LS
GP INT ASSOC BIOL STANDARDIZAT
TI HHV-6 AND HHV-7 AS EXOGENOUS AGENTS IN HUMAN-LYMPHOCYTES
SO INTERNATIONAL SYMPOSIUM ON CONTINUOUS CELL LINES - AN INTERNATIONAL
   WORKSHOP ON CURRENT ISSUES
SE DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION
LA English
DT Proceedings Paper
CT INTERNATIONAL SYMP ON CONTINUOUS CELL LINES
CY MAR 20-22, 1991
CL NIH CAMPUS, BETHESDA, MD
SP US FDA, CTR BIOL EVALUAT & RES, NIAID, NATL VACCINE PROGRAM OFF, WHO
HO NIH CAMPUS
RP FRENKEL, N (reprint author), NIAID,VIRAL DIS LAB,BETHESDA,MD 20892, USA.
NR 0
TC 41
Z9 42
U1 0
U2 0
PU KARGER
PI BASEL
PA BASEL
BN 3-8055-5618-7
J9 DEV BIOLOGICALS
JI Dev. Biols
PY 1992
VL 76
BP 259
EP 265
PG 7
WC Biology; Immunology
SC Life Sciences & Biomedicine - Other Topics; Immunology
GA BW99W
UT WOS:A1992BW99W00030
PM 1335933
ER

PT J
AU INAMDAR, A
   THOMPSON, J
   KASHANCHI, F
   DONIGER, J
   BRADY, JN
   ROSENTHAL, LJ
AF INAMDAR, A
   THOMPSON, J
   KASHANCHI, F
   DONIGER, J
   BRADY, JN
   ROSENTHAL, LJ
TI IDENTIFICATION OF 2 PROMOTERS WITHIN HUMAN CYTOMEGALOVIRUS MORPHOLOGIC
   TRANSFORMING REGION-II
SO INTERVIROLOGY
LA English
DT Article
DE CYTOMEGALOVIRUS; PROMOTERS; MORPHOLOGIC TRANSFORMING; DOMAIN
ID HERPES-SIMPLEX VIRUS; SEQUENCE ANALYSIS; MAMMALIAN-CELLS; DNA;
   INSERTION; LOCALIZATION; ACTIVATION; FRAGMENT; DOMAIN; MTRII
AB A 980-bp subfragment of human cytomegalovirus (HCMV) strain Towne has been previously identified as morphologic transforming region II (mtrII) because of its ability to induce focal transformation of NIH 3T3 cells. Transcripts from this region, which could encode the three open reading frames (ORFs), 79, 83, and 34 amino acids (aa), detected by DNA sequence analysis, are expressed early during HC MV infection. In this report, the mRNA start sites for promoters (P1 and P2) were mapped within Towne mtrII by primer extension using RNAs isolated from transformed NIH 3T3 cells. The Towne mtrll promoters exhibited similar activities to the SV40 enhancerless early promoter. Equivalent promoter activities were detected within the mtrII colinear nontransforming region from HCMV strain Tanaka. Two subclones of Towne mtrII (5'440-bp and 3' 540-bp), each containing one promoter, were generated utilizing a unique BgII site which also interrupted the 79-aa ORF. In transfection assays, neither the 5' 440-bp promoter subclone containing a truncated 79-aa ORF nor the 3' 540-bp subclone containing intact 83- and 34-aa ORFs exhibited transforming activity. These data indicated that transformation by HCMV mtrll did not occur by promoter insertion. The identification of these early promoters will allow further studies on the regulation of important HCMV early genes known to be involved in viral/host interactions.
C1 GEORGETOWN UNIV,MED CTR,DEPT MICROBIOL,WASHINGTON,DC 20007.
   NCI,MOLEC VIROL LAB,BETHESDA,MD 20892.
FU NCI NIH HHS [CA37259-06]
NR 19
TC 6
Z9 6
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0300-5526
J9 INTERVIROLOGY
JI Intervirology
PY 1992
VL 34
IS 3
BP 146
EP 153
DI 10.1159/000150275
PG 8
WC Virology
SC Virology
GA KY637
UT WOS:A1992KY63700005
PM 1338782
ER

PT J
AU GRUIAGRAY, J
   RINGUETTE, M
   DESSER, SS
AF GRUIAGRAY, J
   RINGUETTE, M
   DESSER, SS
TI CYTOPLASMIC LOCALIZATION OF THE DNA VIRUS FROG ERYTHROCYTIC VIRUS
SO INTERVIROLOGY
LA English
DT Article
DE BIOTIN; FROG ERYTHROCYTE CYTOPLASM; FROG ERYTHROCYTIC VIRUS; INSITU
   HYBRIDIZATION
ID ESCHERICHIA-COLI; REPLICATION; MICROSCOPY; ONTARIO; GENOME; CELLS
AB In situ hybridization, using a biotinylated clone of frog erythrocytic virus (FEV), was conducted to determine the location of viral sequences in bullfrog erythrocytes.  FEV-specific hybridization signals were found to correspond to mature cytoplasmic viral particles and assembly sites.  These data are consistent with electron microscopic observations of viral assembly in the erythrocyte cytoplasm.  Although FEV has morphological and biochemical properties similar to frog virus 3, our data suggest that the site of DNA replication and assembly of FEV is more similar to that of the poxviruses.
C1 UNIV TORONTO,DEPT ZOOL,TORONTO M5S 1A1,ONTARIO,CANADA.
RP GRUIAGRAY, J (reprint author), NIDDK,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892, USA.
NR 23
TC 3
Z9 3
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0300-5526
J9 INTERVIROLOGY
JI Intervirology
PY 1992
VL 33
IS 3
BP 159
EP 164
PG 6
WC Virology
SC Virology
GA JC999
UT WOS:A1992JC99900005
PM 1500276
ER

PT J
AU CHOUDHURY, S
   WOODWORTH, CD
   INAMDAR, A
   ELBEIK, T
   DIPAOLO, JA
   ROSENTHAL, LJ
AF CHOUDHURY, S
   WOODWORTH, CD
   INAMDAR, A
   ELBEIK, T
   DIPAOLO, JA
   ROSENTHAL, LJ
TI DIFFERENCES IN RETENTION AND EXPRESSION OF TRANSFECTED HUMAN
   CYTOMEGALOVIRUS TOWNE XBAI-E TRANSFORMING FRAGMENT IN HUMAN CERVICAL AND
   NIH 3T3 LINES
SO INTERVIROLOGY
LA English
DT Article
DE HUMAN CERVICAL CELLS; TRANSFECTED NIH-3T3 CELLS; TRANSFECTED XBAI-E
   TRANSFORMING FRAGMENT OF HCMV TOWNE
ID IMMEDIATE-EARLY GENE; KAPOSIS SARCOMA; PAPILLOMAVIRUS TYPE-16;
   CELL-CULTURES; VIRUS DNA; CMV DNA; KERATINOCYTES; ASSOCIATION;
   INFECTION; SEQUENCES
AB Human cervical and NIH 3T3 cells were transfected with the XbaI-E-transforming fragment of human cytomegalovirus strain Towne. Southern blot hybridization showed that 3 of 4 transformed NIH 3T3 cell lines retained only the mtrII subfragment of Towne XbaI-E, but not the mtrIII subfragment. Even though mtrII was retained, no viral transcripts were detected. Analysis of genomic DNAs isolated from three independently derived lines of Towne XbaI-E-transfected human exocervical epithelial cells previously immortalized by human papillomavirus type 16 (CX16-2/Towne-E) revealed the retention of both mtrII and mtrIII subfragments of Towne XbaI-E even after > 30 subpassages. Southern blot hybridizations indicated the integration and rearrangement of mtrII as well as mtrIII. Poly (A)+RNA analysis of a CX 16-2/Towne-E line revealed a 1.9-kb transcript which hybridized to mtr III. In contrast, no viral transcript from the mtrII region was detected in these cells. The pattern of HPV-16 DNA sequences and the profile of RNA transcripts were similar in the parental human exocervical cells (CX16-2) and in the CX16-2/Towne-E cells. Thus far, the CX16-2/Towne-E lines are nontumorigenic in nude mice. This study highlights not only differences in the ability of Towne XbaI-E to transform rodent cells and not human cells but also differences in the retention and expression of mtrII and mtrIII in these cells.
C1 GEORGETOWN UNIV,MED CTR,DEPT MICROBIOL,WASHINGTON,DC 20007.
   NCI,DIV CANC ETIOL,BIOL LAB,BETHESDA,MD 20892.
OI Elbeik, Tarek/0000-0001-5983-0867
FU NCI NIH HHS [CA37259-05]
NR 30
TC 1
Z9 1
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0300-5526
J9 INTERVIROLOGY
JI Intervirology
PY 1992
VL 33
IS 4
BP 187
EP 196
PG 10
WC Virology
SC Virology
GA JL218
UT WOS:A1992JL21800003
PM 1326497
ER

PT J
AU ROBBINS, SG
   WIGGERT, B
   KUTTY, G
   CHADER, GJ
   DETRICK, B
   HOOKS, JJ
AF ROBBINS, SG
   WIGGERT, B
   KUTTY, G
   CHADER, GJ
   DETRICK, B
   HOOKS, JJ
TI REDISTRIBUTION AND REDUCTION OF INTERPHOTORECEPTOR RETINOID-BINDING
   PROTEIN DURING OCULAR CORONAVIRUS INFECTION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP); MOUSE HEPATITIS
   VIRUS; RETINAL DEGENERATION; IMMUNOHISTOCHEMISTRY; SLOT-BLOT ANALYSIS
ID CREUTZFELDT-JAKOB DISEASE; IRBP; DEGENERATION; LOCALIZATION;
   REPLICATION; RETINITIS
AB Inoculation of the neurotropic coronavirus mouse hepatitis virus strain JHM intravitreally or into the anterior chamber causes acute infection of the retinal pigment epithelium (RPE) and neural retina.  Weeks later, many retinas have foci of moderate to severe atrophy.  The effect of coronavirus infection (after intravitreal inoculation) was examined on interphotoreceptor retinoid-binding protein (IRBP), the glycolipoprotein in the interphotoreceptor matrix (IPM) thought to transport retinoids between the photoreceptors and the RPE.  Changes in IRBP distribution accompanied virus-associated retinal pathology, including photoreceptor loss and RPE abnormalities.  Immunohistochemistry on days 3 and 6 showed that IRBP had diffused into the neural retina away from the IPM.  The IRBP became localized abnormally in the same areas as virus-induced lesions, shown by staining adjacent sections with a monoclonal antibody specific for the viral nuclecapsid protein.  Moreover, the level of IRBP in isolated retinas, measured in an immunoslot-blot assay, decreased significantly by day 3 and remained low through day 23.  This decrease was confirmed in eyecups isolated on day 6.  It may be caused in part by loss of photoreceptors and diffusion of IRBP through the retina into the vitreous.  These studies show that a virus may induce an acute, limited infection in the retina that can be cleared by the host.  However, the infection initiated a series of events resulting in long-term reduction and redistribution of a critical photoreceptor protein.
C1 NEI,IMMUNOL & VIROL SECT,IMMUNOL LAB,BLDG 10,ROOM 6N228,BETHESDA,MD 20892.
   NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 31
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD JAN
PY 1992
VL 33
IS 1
BP 60
EP 67
PG 8
WC Ophthalmology
SC Ophthalmology
GA HA137
UT WOS:A1992HA13700009
PM 1309730
ER

PT J
AU JAMPEL, HD
   BROWN, A
   ROBERTS, A
   KOYA, P
   QUIGLEY, H
AF JAMPEL, HD
   BROWN, A
   ROBERTS, A
   KOYA, P
   QUIGLEY, H
TI EFFECT OF PARACENTESIS UPON THE BLOOD-AQUEOUS BARRIER OF CYNOMOLGUS
   MONKEYS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE PARACENTESIS; BLOOD-AQUEOUS BARRIER; NONHUMAN PRIMATES;
   FLUOROPHOTOMETRY; PROTEIN DETERMINATION
ID GROWTH-FACTOR-BETA; RHESUS-MONKEY; HUMOR; EYE; PROTEIN; BREAKDOWN;
   SURGERY; UVEITIS
AB Anterior chamber paracentesis disrupts the blood aqueous barrier (BAB) of rabbits and nonhuman primates, but the magnitude and duration of breakdown in monkeys has not been clarified.  We have studied anterior chamber paracentesis in cynomolgus monkeys as a potential model of postoperative BAB breakdown.  The effect of a single paracentesis upon fluorescein sodium concentration in the anterior chamber after an intravenous injection was measured in 16 eyes of 8 animals.  In an additional 10 eyes of 5 animals, aqueous humor was withdrawn for analysis 24 hours and one week following paracentesis.
   Anterior chamber fluorescein concentration was 57 +/- 22 ng/ml (mean +/- standard deviation) before paracentesis, rose to 81 +/- 47 ng/ml 24 hrs after paracentesis, and was 60 +/- 36 ng/ml at 72-96 hours.  Twenty-four hours after paracentesis, total protein concentration was elevated, but ascorbic acid and transforming growth factor-beta levels were not.
   Paracentesis in monkeys has only a small and short lasting effect upon BAB integrity and is therefore unlikely to be a good model for assessing the effect of agents designed to stabilize the BAB.  However, the short-lived effect of paracentesis may permit the repetitive collection of "primary aqueous" for physiologic and biochemical studies.
C1 JOHNS HOPKINS UNIV,SCH MED,DEPT OPHTHALMOL,BALTIMORE,MD 21205.
   JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,BALTIMORE,MD 21205.
   NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
RP JAMPEL, HD (reprint author), JOHNS HOPKINS UNIV HOSP,MAUMENEE B-110,600 N WOLFE ST,BALTIMORE,MD 21205, USA.
FU NEI NIH HHS [EY-01765, EY-02120]
NR 34
TC 21
Z9 21
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD JAN
PY 1992
VL 33
IS 1
BP 165
EP 171
PG 7
WC Ophthalmology
SC Ophthalmology
GA HA137
UT WOS:A1992HA13700023
PM 1730538
ER

PT J
AU SINGH, VK
   USUKURA, J
   SHINOHARA, T
AF SINGH, VK
   USUKURA, J
   SHINOHARA, T
TI MOLECULAR MIMICRY - UVEITIS INDUCED IN MACACA-FASICULARIS BY MICROBIAL
   PROTEIN HAVING SEQUENCE HOMOLOGY WITH RETINAL S-ANTIGEN
SO JAPANESE JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
DE EXPERIMENTAL AUTOIMMUNE UVEITIS; LYMPHOCYTE PROLIFERATION;
   MACACA-FASICULARIS; MOLECULAR MIMICRY; PEPTIDE M; S-ANTIGEN; YEAST
   HISTONE H3
ID EXPERIMENTAL AUTOIMMUNE UVEITIS; EXPERIMENTAL ALLERGIC UVEITIS; CELLULAR
   IMMUNE RESPONSIVENESS; UVEITOPATHOGENIC SITE; ALPHA-TRANSDUCIN; BOVINE
   RETINA; LEWIS RATS; UVEORETINITIS; INDUCTION; IDENTIFICATION
AB S-antigen (S-Ag), a well characterized 45-kDa protein in the photoreceptor cells, induces predominantly T-cell-mediated autoimmune uveitis when injected into experimental animals. Recently, we have shown that native histone H3 protein derived from yeast (Saccharomyces cerevisiae), or a synthetic peptide that is homologous with S-Ag peptide M in having six consecutive amino acids, induces experimental autoimmune uveitis (EAU) similar to that induced by native S-Ag in the Lewis rat. In this study, monkeys (Macaca fascicularis) immunized with histone H3 peptide developed a strong cellular immune response to this peptide as well as to peptide M. However, no significant inflammation or hypervascularization was observed in the retina or the iris during the experimental period, when they were examined clinically with an inverted ophthalmoscope. Histopathological examination showed that all monkeys injected with histone H3 peptide or with native histone H3 lost a large number of photoreceptor rod cells and developed neovascularization in the outer nuclear cell layer of the retina. These histopathological findings in the monkey retina closely resemble those seen in human patients with some types of uveitis. The possible involvement of microbial proteins having sequence homology with normal retinal proteins in the pathogenicity of human uveitis is discussed.
C1 NEI,RETINAL CELL & MOLEC BIOL LAB,MOLEC BIOL SECT,BLDG 6,RM 327,BETHESDA,MD 20892.
   NAGOYA UNIV,SCH MED,DEPT ANAT,NAGOYA,AICHI 466,JAPAN.
OI Shinohara, Toshimichi/0000-0002-7197-9039
NR 38
TC 20
Z9 20
U1 0
U2 1
PU JAPAN J OPHTHALMOL
PI HONGO TOKYO
PA UNIV TOKYO-SCH MED DEPT OPHTHALMOLOGY, HONGO TOKYO 113, JAPAN
SN 0021-5155
J9 JPN J OPHTHALMOL
JI Jpn. J. Ophthalmol.
PY 1992
VL 36
IS 1
BP 108
EP 116
PG 9
WC Ophthalmology
SC Ophthalmology
GA HU548
UT WOS:A1992HU54800016
PM 1635290
ER

PT J
AU ENGEL, BT
   SATO, A
   SATO, Y
AF ENGEL, BT
   SATO, A
   SATO, Y
TI RESPONSES OF SYMPATHETIC-NERVES INNERVATING BLOOD-VESSELS IN
   INTERSCAPULAR, BROWN ADIPOSE-TISSUE AND SKIN DURING COLD STIMULATION IN
   ANESTHETIZED C57BL/6J MICE
SO JAPANESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE BROWN ADIPOSE TISSUE; SYMPATHETIC NERVE; COLD STIMULATION; BLOOD FLOW;
   SKIN
ID ACCLIMATED RATS; NONSHIVERING THERMOGENESIS; FLOW; NORADRENALINE;
   CALORIGENESIS; FAT
AB The effect of cold stimulation on the activity of sympathetic nerves running along blood vessels in interscapular, brown adipose tissues (IBAT) and skin overlying IBAT was examined in 15, urethane-anesthetized, artificially ventilated, C57BL/6J mice. Cold stimulation was applied caudal to the pelvic area using a plastic bag containing iced water. The stimulation of 14-16 min duration reduced core temperature measured at the esophagus or muscle near the esophagus by approximately 4-degrees-C from a control temperature of about 38-degrees-C. The stimulation decreased the activity of the nerve branches to IBAT, while it increased the activity of the nerve branches to skin. Blood flow in the IBAT increased significantly following the stimulation; however, this effect was abolished by the denervation. These findings suggest that the sympathetic innervation of the blood vessels in the IBAT plays a major role in thermoregulation against cold by decreasing the vascular tone and thus increasing the IBAT blood flow. An increase in the IBAT blood flow would facilitate the dissipation of heat from the IBAT to various organs as well as the supply of energy stuffs to the IBAT.
C1 TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT AUTONOM NERVOUS SYST,ITABASHI KU,TOKYO 173,JAPAN.
   NIA,GERONTOL RES CTR,BEHAV SCI LAB,BETHESDA,MD 20892.
   TSUKUBA COLL TECHNOL,PHYSIOL LAB,TSUKUBA 305,JAPAN.
NR 18
TC 8
Z9 8
U1 0
U2 0
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 4-16 YAYOI 2-CHOME, BUNKYO-KU, TOKYO 113, JAPAN
SN 0021-521X
J9 JPN J PHYSIOL
JI Jpn. J. Physiol.
PY 1992
VL 42
IS 4
BP 549
EP 559
DI 10.2170/jjphysiol.42.549
PG 11
WC Physiology
SC Physiology
GA JN540
UT WOS:A1992JN54000002
PM 1474676
ER

PT J
AU TASAKI, I
   BYRNE, PM
AF TASAKI, I
   BYRNE, PM
TI HEAT-PRODUCTION ASSOCIATED WITH A PROPAGATED IMPULSE IN BULLFROG
   MYELINATED NERVE-FIBERS
SO JAPANESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE NERVE HEAT PRODUCTION; MYELINATED NERVE FIBERS
AB By using heat-sensors constructed with thin film of polyvinylidene fluoride, it was found possible to detect the heat generated by myelinated fibers in the bullfrog sciatic nerve in association with a propagated impulse. The quantity of heat generated (about 0.4 mucal/g at 4.5-degrees-C) is roughly two orders of magnitude smaller than that observed in nerves containing only non-myelinated nerve fibers. The smallness of the heat observed is attributed to the localization of the heat sources at the nodes of Ranvier. The major portion of the heat generated is re-absorbed by the nerve.
RP TASAKI, I (reprint author), NIMH,CELL BIOL LAB,BETHESDA,MD 20892, USA.
NR 18
TC 11
Z9 13
U1 0
U2 1
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 4-16 YAYOI 2-CHOME, BUNKYO-KU, TOKYO 113, JAPAN
SN 0021-521X
J9 JPN J PHYSIOL
JI Jpn. J. Physiol.
PY 1992
VL 42
IS 5
BP 805
EP 813
DI 10.2170/jjphysiol.42.805
PG 9
WC Physiology
SC Physiology
GA KD145
UT WOS:A1992KD14500011
PM 1491504
ER

PT J
AU ASHORN, P
   MOSS, B
   BERGER, EA
AF ASHORN, P
   MOSS, B
   BERGER, EA
TI ACTIVITY OF CD4-PSEUDOMONAS EXOTOXIN AGAINST CELLS EXPRESSING DIVERSE
   FORMS OF THE HIV AND SIV ENVELOPE GLYCOPROTEINS
SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
LA English
DT Article
DE ANTIVIRAL DRUGS; CD4-PSEUDOMONAS EXOTOXIN; HIV ENVELOPE GLYCOPROTEIN;
   GP160 PRECURSOR CLEAVAGE; CD4 BINDING AFFINITY
ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT VACCINIA VIRUS; SOLUBLE CD4;
   HYBRID PROTEIN; PSEUDOMONAS EXOTOXIN; SYNCYTIUM FORMATION; INFECTED
   CELLS; TYPE-1; INVITRO; GP120
AB CD4(178)-PE40 is a genetically engineered hybrid toxin containing a portion of human CD4 linked to the translocation and ADP-ribosylation domains of Pseudomonas exotoxin A.  In vitro, the molecule has been shown to selectively kill cells expressing the envelope glycoproteins of human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV), and to inhibit HIV spread.  In this report we examine the activity of the hybrid toxin against cells expressing diverse forms of the HIV and SIV envelope glycoproteins, encoded by recombinant vaccinia virus vectors.  The activity of CD4(178)-PE40 was found to be unaffected by mutations in the HIV-1 or HIV-2 envelope glycoprotein genes, which prevent normal proteolytic processing of the corresponding gp 160 precursor molecules.  Cells expressing a mutant HIV-1 envelope glycoprotein lacking most of the cytoplasmic tail of the gp41 transmembrane subunit were also sensitive to the hybrid toxin.  Most interestingly, HIV-1, HIV-2, and SIV(mac) envelope glycoprotein molecules known to have widely differing affinities for CD4 were found to be comparably effective at mediating sensitivity to CD4(178)-PE40.  By virtue of its ability to kill infected cells, the hybrid toxin inhibited the spread of SIV(mac) in vitro.  These results indicate that CD4(178)-PE40 is active against cells expressing HIV and SIV envelope glycoproteins with a diverse array of structural differences.
C1 NIAID,VIRAL DIS LAB,BLDG 4,RM 210,BETHESDA,MD 20892.
   UNIV TAMPERE,DEPT BIOMED SCI,TAMPERE,FINLAND.
NR 35
TC 14
Z9 14
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 1077-9450
J9 J ACQ IMMUN DEF SYND
JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.
PD JAN
PY 1992
VL 5
IS 1
BP 70
EP 77
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA GW913
UT WOS:A1992GW91300012
PM 1738090
ER

PT J
AU BLACKWELDER, WC
AF BLACKWELDER, WC
TI DESIGN OF ACTIVE CONTROL EQUIVALENCE TRIALS
SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
LA English
DT Letter
RP BLACKWELDER, WC (reprint author), NIAID,BETHESDA,MD 20892, USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 1077-9450
J9 J ACQ IMMUN DEF SYND
JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.
PD JAN
PY 1992
VL 5
IS 1
BP 102
EP 103
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA GW913
UT WOS:A1992GW91300017
PM 1738080
ER

PT J
AU POLIS, MA
AF POLIS, MA
TI FOSCARNET AND GANCICLOVIR IN THE TREATMENT OF CYTOMEGALOVIRUS RETINITIS
SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
LA English
DT Article; Proceedings Paper
CT ROUNDTABLE ON FOSCARNET THERAPY IN PERSONS WITH AIDS : CLINICAL RESEARCH
   AND MANAGEMENT CONSIDERATIONS
CY SEP   30, 1991
CL CHICAGO, IL
SP ASTRA PHARM PROD
DE AIDS; CMV RETINITIS; FOSCARNET; GANCICLOVIR; MAINTENANCE THERAPY;
   SURVIVAL
ID IMMUNE-DEFICIENCY-SYNDROME; ACQUIRED IMMUNODEFICIENCY SYNDROME; VIRUS
   RETINITIS; PHOSPHONOFORMATE FOSCARNET; THERAPY; INVITRO; AIDS;
   3'-AZIDO-3'-DEOXYTHYMIDINE; COMBINATIONS; RETINOPATHY
AB Induction regimens of foscarnet and ganciclovir are highly effective in arresting cytomegalovirus (CMV) retinitis in patients with AIDS. Chronic maintenance therapy is nonetheless required to forestall progression of disease following induction. In open studies of these two agents in AIDS patients with CMV retinitis at dosages similar to those currently recommended. median times to retinitis progression during maintenance therapy of as long as > 100 days have been observed. In a randomized comparative trial of immediate and delayed foscarnet treatment utilizing rigorously defined end points, the mean times to retinitis progression were 13.3 weeks among patients receiving immediate foscarnet therapy and 3.2 weeks among those receiving no treatment. In a similar trial of ganciclovir, the mean times to progression were 68.5 days among patients receiving immediate treatment and 22.9 days among those receiving no treatment. Experience in a number of studies not designed to assess mortality has suggested that specific antiviral treatment for CMV retinitis is associated with prolongation of survival. One retrospective analysis of survival patterns in patients treated with ganciclovir has suggested a significant effect of this agent on survival; another analysis has shown no association between anti-CMV therapy and survival, with the relative hazard of death among patients receiving foscarnet therapy being equivalent to that among patients receiving ganciclovir therapy. In the one randomized study comparing the mortality of patients receiving initial treatment with either foscarnet or ganciclovir, foscarnet-treated patients had a median survival of 12.6 months compared with 8.5 months for ganciclovir-treated patients. Foscarnet may prove to have a therapeutic advantage via in vivo inhibition of human immunodeficiency virus replication, although the magnitude and clinical significance of this effect have yet to be ascertained.
RP POLIS, MA (reprint author), NIH,AIDS INTRAMURAL PROGRAM,BETHESDA,MD 20892, USA.
NR 27
TC 19
Z9 19
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 1077-9450
J9 J ACQ IMMUN DEF SYND
JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.
PY 1992
VL 5
SU 1
BP S3
EP S10
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA JA191
UT WOS:A1992JA19100002
PM 1318365
ER

PT J
AU ABRAMS, S
   SILBER, T
   ESTEBAN, N
   VIEIRA, N
   MEYERS, R
   BELL, N
   SHARY, J
   YERGEY, A
AF ABRAMS, S
   SILBER, T
   ESTEBAN, N
   VIEIRA, N
   MEYERS, R
   BELL, N
   SHARY, J
   YERGEY, A
TI DECREASED CALCIUM (CA) ABSORPTION IN ADOLESCENTS WITH ANOREXIA-NERVOSA
   IS ASSOCIATED WITH DECREASED BONE CA FLOW AND INCREASED URINARY CA
   EXCRETION
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Meeting Abstract
C1 UNIV S CAROLINA,COLUMBIA,SC 29208.
   CHILDRENS NUTR RES CTR,HOUSTON,TX.
   NICHHD,LTPB,BETHESDA,MD.
   CHILDRENS NATL MED CTR,DEPT ADOLESCENT MED,WASHINGTON,DC.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JAN
PY 1992
VL 13
IS 1
BP 48
EP 48
DI 10.1016/1054-139X(92)90266-E
PG 1
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA HB759
UT WOS:A1992HB75900018
ER

PT J
AU DANGELO, LJ
AF DANGELO, LJ
TI THE PARTICIPATION OF ADOLESCENTS IN AIDS CLINICAL-TRIALS
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Meeting Abstract
C1 NIAID,DIV AIDS,BETHESDA,MD 20892.
   CHILDRENS NATL MED CTR,WASHINGTON,DC.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JAN
PY 1992
VL 13
IS 1
BP 49
EP 49
DI 10.1016/1054-139X(92)90269-H
PG 1
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA HB759
UT WOS:A1992HB75900021
ER

PT J
AU GAWIN, AZ
   BARANIUK, JN
   KALINER, MA
AF GAWIN, AZ
   BARANIUK, JN
   KALINER, MA
TI THE EFFECT OF SUBSTANCE-P (SP) AND CALCITONIN GENE RELATED PEPTIDE
   (CGRP) ON GUINEA-PIG (GP) NASAL MUCOSAL
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-YEAR BOOK INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD JAN
PY 1992
VL 89
IS 1
BP 210
EP 210
PN 2
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA HB760
UT WOS:A1992HB76000216
ER

PT J
AU PEDEN, D
   SWIERSZ, M
   OHKUBO, K
   HAHN, B
   KALINER, M
AF PEDEN, D
   SWIERSZ, M
   OHKUBO, K
   HAHN, B
   KALINER, M
TI ELUCIDATION OF THE SOURCE OF CHOLINERGICALLY-INDUCED NASAL SECRETORY
   URIC-ACID
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-YEAR BOOK INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD JAN
PY 1992
VL 89
IS 1
BP 210
EP 210
PN 2
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA HB760
UT WOS:A1992HB76000214
ER

PT J
AU WAYTES, AT
   HUBER, M
   LITTON, G
   ALLING, D
   FRANK, MM
AF WAYTES, AT
   HUBER, M
   LITTON, G
   ALLING, D
   FRANK, MM
TI USE OF A VAPOR-HEATED C1 INHIBITOR PREPARATION IN HEREDITARY ANGIOEDEMA
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MOSBY-YEAR BOOK INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD JAN
PY 1992
VL 89
IS 1
BP 247
EP 247
PN 2
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA HB760
UT WOS:A1992HB76000364
ER

PT J
AU GEORGE, MS
   BALLENGER, JC
AF GEORGE, MS
   BALLENGER, JC
TI THE NEUROANATOMY OF PANIC DISORDER - THE EMERGING ROLE OF THE RIGHT
   PARAHIPPOCAMPAL REGION
SO JOURNAL OF ANXIETY DISORDERS
LA English
DT Article
ID ATTACKS; SEIZURES; ANXIETY; EEG; ABNORMALITIES; LACTATE
AB Recent brain imaging and case report data suggest that a right temporal lobe abnormality, specifically involving the right parahippocampal region, may play an important role in the pathogenesis of some forms of panic disorder.  The authors explore the interesting link between ictal fear in complex partial epilepsy, case reports of panic patients with focal temporal lobe pathology, and cocaine-induced panic.  This is systematized into a proposed neuroanatomic theory of the pathogenesis of panic disorder involving the right temporal lobe and other brain regions.
C1 INST NEUROL,LONDON WC1N 3BG,ENGLAND.
   MED UNIV S CAROLINA,DEPT PSYCHIAT & BEHAV SCI,CHARLESTON,SC 29425.
RP GEORGE, MS (reprint author), NIMH,BIOL PSYCHIAT BRANCH,BLDG 10,ROOM 3N212,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 42
TC 18
Z9 18
U1 2
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0887-6185
J9 J ANXIETY DISORD
JI J. Anxiety Disord.
PY 1992
VL 6
IS 2
BP 181
EP 188
DI 10.1016/0887-6185(92)90016-Z
PG 8
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA HP125
UT WOS:A1992HP12500009
ER

PT J
AU SCHULZ, LO
   ALGER, S
   HARPER, I
   WILMORE, JH
   RAVUSSIN, E
AF SCHULZ, LO
   ALGER, S
   HARPER, I
   WILMORE, JH
   RAVUSSIN, E
TI ENERGY-EXPENDITURE OF ELITE FEMALE RUNNERS MEASURED BY RESPIRATORY
   CHAMBER AND DOUBLY LABELED WATER
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE ENERGY BALANCE; EXERCISE TRAINING; INDIRECT CALORIMETRY
ID DISTANCE RUNNERS; BALLET DANCERS; WOMEN RUNNERS; HUMANS; BODY; MALES;
   MASS; MEN; FAT
AB To determine whether female athletes have unusually low energy requirements as suggested by many food intake studies, energy expenditure (EE) and intake were assessed in nine elite distance runners [26 +/- 3 (SD) yr, 53 +/- 4 kg, 12 +/- 3% body fat, and 66 +/- 4 ml . kg-1 . min-1 maximal O2 uptake]. Subjects were admitted to a metabolic ward for 40 h during which 24-h sedentary EE was measured in a respiratory chamber. Free-living EE was then assessed by the doubly labeled water method for the next 6 days while the women recorded all food intake, daily body weight, and training mileage (10 +/- 3 miles/day). Energy intakes estimated from free-living EE (2,826 +/- 312 kcal/day) and body weight changes (-84 +/- 71 g/day) averaged 221 +/- 550 kcal/day in excess of those calculated from food records (2,193 +/- 466 kcal/day). The energy cost of training (1,087 +/- 244 kcal/day) was calculated as the difference between free-living EE and 24-h EE in the respiratory chamber (1,681 +/- 84 kcal/day) corrected for the thermic effect of food of the extra energy intake. These data do not support the hypothesis that training as a distance runner results in metabolic adaptations that lower energy requirements in women.
C1 NIDDKD,CLIN DIABET & NUTR SECT,PHOENIX,AZ 85016.
   UNIV TEXAS,DEPT KINESIOL & HLTH EDUC,AUSTIN,TX 78712.
RP SCHULZ, LO (reprint author), UNIV WISCONSIN,DEPT HLTH SCI,POB 413,MILWAUKEE,WI 53201, USA.
NR 34
TC 77
Z9 77
U1 2
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD JAN
PY 1992
VL 72
IS 1
BP 23
EP 28
PG 6
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA HA815
UT WOS:A1992HA81500004
PM 1537719
ER

PT J
AU KELLY, R
   KWONCHUNG, KJ
AF KELLY, R
   KWONCHUNG, KJ
TI A ZINC FINGER PROTEIN FROM CANDIDA-ALBICANS IS INVOLVED IN SUCROSE
   UTILIZATION
SO JOURNAL OF BACTERIOLOGY
LA English
DT Article
ID AMINO-ACID SEQUENCE; SACCHAROMYCES-CEREVISIAE; REGULATORY GENE;
   ESCHERICHIA-COLI; MAL6 LOCUS; NUCLEOTIDE-SEQUENCE; ALPHA-GLUCOSIDASE;
   MULTIGENE FAMILY; BINDING-SITES; MALTASE GENE
AB A sucrose-inducible a-glucosidase activity that hydrolyzes sucrose in Candida albicans has been demonstrated previously. The enzyme is assayable in whole cells and was inhibited by both sucrose and maltose. A C. albicans gene (CASUC1) that affects sucrose utilization and alpha-glucosidase activity was cloned by expression in a Saccharomyces cerevisiae suc2 mutant (2102) devoid of invertase genes. CASUC1 enabled the S. cerevisiae mutant to utilize both sucrose and maltose. DNA sequence analysis revealed that CASUC1 encodes a putative zinc finger-containing protein with 28% identity to a maltose-regulatory gene (MAL63) of S. cerevisiae. The gene products of CASUC1 and MAL63 are approximately the same size (501 and 470 amino acids, respectively), and each contains a single zinc finger located at the N terminus. The zinc fingers of CASUC1 and MAL63 comprise six conserved cysteines (C6 zinc finger) and are of the general form Cys-Xaa2-Cys-Xaa6-Cys-Xaa (variable)-Cys-Xaa2-Cys-Xaa6-Cys (where Xaa(n) indicates a stretch of the indicated number of any amino acids). Both contain five amino acids in the variable region. CASUC1 also complemented the maltose utilization defect of an S. cerevisiae mutant (TCY-137) containing a defined mutation in a maltose-regulatory gene. The sucrose utilization defect of type II Candida stellatoidea, a sucrase-negative mutant of C. albicans, was corrected by CASUC1. Determinations of alpha-glucosidase activity in whole cells revealed that activity was restored in transformants cultivated on either sucrose or maltose. To our knowledge, this is the first zinc finger-encoding gene, as well as the first putative regulatory gene, to be identified in C. albicans.
C1 NIAID,CLIN INVEST LAB,BETHESDA,MD 20892.
NR 62
TC 29
Z9 31
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0021-9193
J9 J BACTERIOL
JI J. Bacteriol.
PD JAN
PY 1992
VL 174
IS 1
BP 222
EP 232
PG 11
WC Microbiology
SC Microbiology
GA GZ442
UT WOS:A1992GZ44200032
PM 1729210
ER

PT J
AU MARCONI, RT
   GARON, CF
AF MARCONI, RT
   GARON, CF
TI PHYLOGENETIC ANALYSIS OF THE GENUS BORRELIA - A COMPARISON OF
   NORTH-AMERICAN AND EUROPEAN ISOLATES OF BORRELIA-BURGDORFERI
SO JOURNAL OF BACTERIOLOGY
LA English
DT Article
ID LYME-DISEASE; RESTRICTION PATTERNS; RNA; HYBRIDIZATION; CULTIVATION;
   SYSTEM
AB We have sequenced the 16S rRNA molecules from four species of Borrelia and from six isolates of Borrelia burgdorferi via the reverse transcriptase primer extension method. The sequences were aligned and evolutionary relationships were determined, including the calculation of evolutionary distances and the construction of a phylogenetic tree. These analyses demonstrate significant divergence among B. burgdorferi isolates, with the European isolates G1 and G2 residing most distant from the main cluster. Signature nucleotides which distinguish B. burgdorferi from all other members of this genus and which distinguish the European isolates G1 and G2 from the North American isolates B31, Sh-2-82, and 1352 were identified. Finally, Southern blot analyses were performed to compare the restriction patterns of the genes coding for rRNA 'and to relate our data to the grouping scheme of Postic et al. (D. Postic, C. Edlinger, C. Richaud, F. Grimont, J. Dufresne, P. Perolat, G. Baranton, and P. A. D. Grimont, Res. Microbiol. 141:465-475, 1990).
RP MARCONI, RT (reprint author), NIAID,ROCKY MT LABS,VECTORS & PATHOGENS LAB,HAMILTON,MT 59840, USA.
NR 23
TC 86
Z9 86
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0021-9193
J9 J BACTERIOL
JI J. Bacteriol.
PD JAN
PY 1992
VL 174
IS 1
BP 241
EP 244
PG 4
WC Microbiology
SC Microbiology
GA GZ442
UT WOS:A1992GZ44200034
PM 1370282
ER

PT J
AU IZUMI, T
   SCULLY, SP
   HEYDEMANN, A
   BOLANDER, ME
AF IZUMI, T
   SCULLY, SP
   HEYDEMANN, A
   BOLANDER, ME
TI TRANSFORMING GROWTH FACTOR-BETA-1 STIMULATES TYPE-II COLLAGEN EXPRESSION
   IN CULTURED PERIOSTEUM-DERIVED CELLS
SO JOURNAL OF BONE AND MINERAL RESEARCH
LA English
DT Article
ID FACTOR-BETA; MESSENGER-RNAS; TGF-BETA; OSTEOGENIC CAPACITY; PHENOTYPES
   INVITRO; PLATE CHONDROCYTES; MATRIX SYNTHESIS; GENE-EXPRESSION; LONG
   BONES; CARTILAGE
AB Chondrogenesis can occur during a bone repair process, which is related to several growth factors. Transforming growth factor beta-1, (TGF-beta-1) downregulates the expression of type II collagen by chondrocytes in vitro, but injection of TGF-beta-1 into the periosteum in vivo increases type II collagen mRNA levels and initiates chondrogenesis. (1)  We examined the effect of TGF-beta-1 on collagen gene expression in a bovine periosteum-derived cell culture system to evaluate its direct effect on the periosteum. Cultured cells expressed alkaline phosphatase and collagen pro-alpha-1(I) and pro-alpha-1(II) mRNAs. A low level of type II collagen synthesis was demonstrated by immunoprecipitation. TGF-beta-1 had no effect on periosteal cell proliferation. Expression of collagen pro-alpha-1(I) mRNA did not change with TGF-beta-1 treatment, but alkaline phosphatase mRNA showed a dose-dependent decrease. Expression of collagen pro-alpha-1(II) mRNA was stimulated 2.7-fold by TGF-beta-1. TGF-beta-1 also caused a 2.6-fold increase in type II collagen synthesis by immunoprecipitation. These findings indicate that TGF-beta-1 is an enhancer of the expression of the chondrocyte phenotype of the periosteal cells and suggest that TGF-beta-1 is important in initiating and promoting cartilage formation in vivo.
C1 NIAMSD,ORTHOPAED RES UNIT,BETHESDA,MD.
NR 49
TC 83
Z9 83
U1 0
U2 1
PU BLACKWELL SCIENCE INC
PI MALDEN
PA 350 MAIN ST, MALDEN, MA 02148
SN 0884-0431
J9 J BONE MINER RES
JI J. Bone Miner. Res.
PD JAN
PY 1992
VL 7
IS 1
BP 115
EP 121
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA GZ684
UT WOS:A1992GZ68400015
PM 1549955
ER

PT J
AU PETRAKOVA, E
   YEH, HJC
   KOVAC, P
   GLAUDEMANS, CPJ
AF PETRAKOVA, E
   YEH, HJC
   KOVAC, P
   GLAUDEMANS, CPJ
TI 2 METHYL TRI-O-BENZOYL-HEXENOPYRANOSIDES ARE AMONGST THE PRODUCTS OF THE
   REACTION OF METHYL 2, 3, 6-TRI-O-BENZOYL-BETA-D-GALACTOPYRANOSIDE WITH
   DIMETHYLAMINOSULFUR TRIFLUORIDE (DAST)
SO JOURNAL OF CARBOHYDRATE CHEMISTRY
LA English
DT Note
ID PHOSPHATES
C1 NIDDK, BETHESDA, MD 20892 USA.
NR 21
TC 6
Z9 6
U1 1
U2 2
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0732-8303
J9 J CARBOHYD CHEM
JI J. Carbohydr. Chem.
PY 1992
VL 11
IS 3
BP 407
EP 412
DI 10.1080/07328309208018003
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Organic
SC Biochemistry & Molecular Biology; Chemistry
GA HT152
UT WOS:A1992HT15200015
ER

PT J
AU KOVAC, P
AF KOVAC, P
TI SYNTHESIS OF LIGANDS RELATED TO THE O-SPECIFIC ANTIGEN OF
   SHIGELLA-DYSENTERIAE TYPE-1 .4. ENHANCED STEREOSELECTIVITY OF
   ALPHA-D-GALACTOSYLATION IN THE SYNTHESIS OF THE SEQUENCE
   ALPHA-D-GALP-(1-]3)-ALPHA-D-GLCPNAC, ALLOWING FURTHER EXTENSION OF THE
   CHAIN AT C-2'
SO JOURNAL OF CARBOHYDRATE CHEMISTRY
LA English
DT Article
ID 1,6-ANHYDRO-BETA-D-GLUCOPYRANOSE DERIVATIVES; OLIGOSACCHARIDES;
   CATALYST; GLYCOSIDES; PROTECTION; ACTIVATION; CHLORIDES; ACETALS;
   IODINE; ACID
AB Stereoselective alpha-D-galactosylation at the position 3 of 4,6-O-substituted derivatives of methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside is described. Glycosyl chlorides derived from 3,4,6-tri-O-acetyl-2-O-benzyl- and 2-O-(4-methoxybenzyl)-D-galactopyranose have been used as glycosyl donors. Methyl 2-acetan-lido-4,6-di-O-acetyl-2-deoxy-3-O-(3,4,6-tri-O-acetyl-alpha-D-galactopyranosyl)-alpha-D-glucopyranoside (27) and methyl 2-acetamido-4,6-di-O-benzyl-2-deoxy-3-O-(3,4,6-tri-O-acetyl-alpha-D-galactopyranosyl)-alpha-D-glucopyranoside (31) have been prepared.
RP KOVAC, P (reprint author), NIDDK,BETHESDA,MD 20892, USA.
NR 28
TC 4
Z9 4
U1 1
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0732-8303
J9 J CARBOHYD CHEM
JI J. Carbohydr. Chem.
PY 1992
VL 11
IS 8
BP 999
EP 1014
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Organic
SC Biochemistry & Molecular Biology; Chemistry
GA JY717
UT WOS:A1992JY71700003
ER

PT J
AU FRIEDMAN, LM
   SCHRON, EB
AF FRIEDMAN, LM
   SCHRON, EB
TI STATISTICAL PROBLEMS IN THE DESIGN OF ANTIARRHYTHMIC DRUG TRIALS
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE ANTIARRHYTHMIC DRUGS; TRIALS; DESIGN
ID ARRHYTHMIA SUPPRESSION TRIAL
AB Although many aspects of design, monitoring, and analysis in trials of antiarrhythmic drugs are similar to those of other intervention studies, several features are different. These include decisions on how to identify the subjects, timing of the intervention with respect to the disease process, time of randomization, methods for measurement of outcome, and interim monitoring for harm or benefit. The resolution of these issues depends almost entirely on the specification of the question of interest.
RP FRIEDMAN, LM (reprint author), NHLBI, FED BLDG, ROOM 5C01, 7550 WISCONSIN AVE, BETHESDA, MD 20892 USA.
NR 11
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PY 1992
VL 20
SU 2
BP S114
EP S118
DI 10.1097/00005344-199220002-00016
PG 5
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA JR146
UT WOS:A1992JR14600017
PM 1279303
ER

PT J
AU MINIE, M
   CLARK, D
   TRAINOR, C
   EVANS, T
   REITMAN, M
   HANNON, R
   GOULD, H
   FELSENFELD, G
AF MINIE, M
   CLARK, D
   TRAINOR, C
   EVANS, T
   REITMAN, M
   HANNON, R
   GOULD, H
   FELSENFELD, G
TI DEVELOPMENTAL REGULATION OF GLOBIN GENE-EXPRESSION
SO JOURNAL OF CELL SCIENCE
LA English
DT Article; Proceedings Paper
CT 1992 SPRING MEETING OF THE BRITISH SOC FOR CELL BIOLOGY :
   TRANSCRIPTIONAL REGULATION IN CELL DIFFERENTATION AND DEVELOPMENT
CY APR, 1992
CL BRIGHTON, ENGLAND
SP BRIT SOC CELL BIOL
DE ERYTHROID DEVELOPMENT; GATA-1; CHROMATIN; TRANSCRIPTION
ID ERYTHROID TRANSCRIPTION FACTOR; CHICKEN BETA-GLOBIN; DNA-BINDING
   PROTEIN; CHROMATIN STRUCTURE; TRANSGENIC MICE; ENHANCER; PROMOTER;
   REGION; SEQUENCE; DOMAINS
AB We have used the globin family of genes in chicken to study developmental regulation of gene expression, both at the level of individual interaction of trans-acting factors with local promoters and enhancers, and at the level of chromatin structure. Regulation of all members of the alpha- and beta-globin clusters is affected by the erythroid regulatory factor GATA-1. Separate mechanisms exist for regulation of individual members of the family. As an example, we describe the control mechanisms that play a role in the expression of the rho-globin gene, which is expressed only in primitive lineage erythroid cells. In addressing the involvement of chromatin structure in gene activation, we have examined the role of locus control elements, and also considered the way in which RNA polymerase molecules might accommodate to the presence of nucleosomes on transcribed genes.
C1 UNIV LONDON KINGS COLL,DIV BIOMOLEC SCI,LONDON WC2B 5RL,ENGLAND.
RP MINIE, M (reprint author), NIDDK,MOLEC LAB,BETHESDA,MD 20892, USA.
NR 37
TC 1
Z9 1
U1 0
U2 0
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS,
   ENGLAND CB4 4DL
SN 0021-9533
J9 J CELL SCI
JI J. Cell Sci.
PY 1992
SU 16
BP 15
EP 20
PG 6
WC Cell Biology
SC Cell Biology
GA KQ210
UT WOS:A1992KQ21000004
ER

PT J
AU KELLOFF, GJ
   BOONE, CW
   MALONE, WF
   STEELE, VE
   DOODY, LA
AF KELLOFF, GJ
   BOONE, CW
   MALONE, WF
   STEELE, VE
   DOODY, LA
TI DEVELOPMENT OF CHEMOPREVENTIVE AGENTS FOR BLADDER-CANCER
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE BLADDER CANCER; CHEMOPREVENTION; INTERMEDIATE BIOMARKERS; INTERMEDIATE
   END-POINT BIOMARKERS; SURROGATE END-POINTS
ID RAT URINARY-BLADDER; N-ACETYLCYSTEINE; ALPHA-DIFLUOROMETHYLORNITHINE;
   ORNITHINE DECARBOXYLASE; MOUSE SKIN; CARCINOGENESIS; INHIBITION;
   PREVENTION; CHEMOTHERAPY; GLUTATHIONE
AB The term cancer chemoprevention refers to the prevention or prolongation of carcinogenesis by intervention with drugs prior to the malignant (i.e., invasive) stage. The development of chemopreventive drugs is the major objective of the Chemoprevention Branch of the National Cancer Institute. Neoplastic lesions of the urinary bladder present a unique opportunity for evaluating chemopreventive agents because of (1) the accessibility of the lesions to observation and biopsy, and (2) those patients who have been successfully treated for a primary lesion represent a population at unusually high risk for recurrence and/or progression.
   Although 70-80% of bladder cancers initially present as superficial, papillary transitional cell neoplasms with limited potential for invasion, the incidence of recurrence is high after resection (60-75%). Recurrent tumors are highly unpredictable, and may be of higher grade or stage (progression). Although recurrence is responsible for high treatment-related morbidity, progression represents the greatest potential for mortality. Thus, potential chemopreventive agents considered here would modulate bladder carcinogenesis from initiation of normal-appearing tissue through progression of superficial tumors.
   Clinical trials of chemopreventive drugs involve healthy target populations, and the endpoints are reduced cancer incidence or mortality, reduced/eliminated precancerous lesions or increased latency, with none to minimal toxicity. Since cancers may not appear for 20-30 years, two of the most difficult aspects of testing these drugs in intervention trials are the long observation periods and large study populations required to measure cancer incidence reduction. However, observing the regression or recurrence of superficial bladder lesions (TIS, T1, Ta) requires relatively short time periods. Thus, these lesions lend themselves to the investigation of intermediate biomarkers, defined as morphologic and/or molecular alterations in tissue between initiation and tumor invasion. It is hypothesized that modulation of one or more biomarkers would interrupt carcinogenesis and result in a decrease in cancer incidence. Thus, evaluation of biomarkers as surrogate endpoints would allow bladder trials to be of even shorter duration, use fewer subjects and be lower in cost. In addition, intermediate biomarkers could predict which superficial lesions (or normal-appearing tissue) have the greatest potential for neoplastic progression. Development of strategies for the design of intervention trials for bladder cancer and review of the current status of intermediate biomarkers in the bladder, and methods for their validation, are major objectives of this workshop.
C1 CCS ASSOCIATES,PALO ALTO,CA 94301.
RP KELLOFF, GJ (reprint author), NCI,CHEMOPREVENT BRANCH,EXECUT PLAZA N,SUITE 201,6130 EXECUT BLVD,BETHESDA,MD 20892, USA.
NR 48
TC 6
Z9 6
U1 1
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16I
BP 1
EP 12
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KV875
UT WOS:A1992KV87500002
ER

PT J
AU KELLOFF, GJ
   BOONE, CW
   MALONE, WF
   STEELE, VE
   DOODY, LA
AF KELLOFF, GJ
   BOONE, CW
   MALONE, WF
   STEELE, VE
   DOODY, LA
TI INTRODUCTORY-REMARKS - DEVELOPMENT OF CHEMOPREVENTIVE AGENTS FOR
   PROSTATE-CANCER
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Editorial Material
DE CHEMOPREVENTION; CLINICAL TRIALS; INTERMEDIATE BIOMARKERS; PROSTATE
ID PREVENTION; CARCINOMA; RETINOIDS
AB The term ''cancer chemoprevention'' refers to the prevention of cancer by intervening with drugs prior to the malignant (i.e., invasive) stage of carcinogenesis. The development of chemopreventive drugs is the major objective of the Chemoprevention Branch at the National Cancer Institute.
   The testing of drugs for cancer chemoprevention differs from testing of those for cancer treatment. Chemopreventive drug trials involve healthy target populations, and the endpoints of reduced cancer incidence or mortality, reduced/eliminated precancerous lesions, or increased latency must be achieved with little or no drug toxicity.
   The design of cancer chemoprevention trials for prostate presents several problems, such as the age of the study population and undependable methods for detecting microscopic foci by sequential sampling. A major motivation for organizing this workshop is the development of strategies for the design of chemopreventive intervention trials for prostate cancer.
   One of the most difficult problems of chemoprevention drug testing is the necessity of lengthy trials due to the long developmental period of many cancers. This is especially true for prostate cancer. A major solution to the problem is the use of intermediate biomarkers, defined as morphological or molecular intraepithelial changes that can constitute short-term endpoints in chemoprevention clinical trials. They are categorized as histological, genetic, proliferation-related, and differentiation-related. Modulation of intermediate biomarkers, instead of cancer incidence, as trial endpoints would allow chemoprevention trials to be of shorter duration, to use fewer subjects, and to be of lower cost. Review of the current status of prostatic intermediate biomarkers, and methods for identifying and validating them, are also major reasons for convening this workshop.
C1 CCS ASSOCIATES,PALO ALTO,CA 94301.
RP KELLOFF, GJ (reprint author), NCI,BETHESDA,MD 20892, USA.
NR 23
TC 6
Z9 6
U1 1
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16H
BP 1
EP 8
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KK164
UT WOS:A1992KK16400002
ER

PT J
AU KELLOFF, GJ
   MALONE, WF
   BOONE, CW
   STEELE, VE
   DOODY, LA
AF KELLOFF, GJ
   MALONE, WF
   BOONE, CW
   STEELE, VE
   DOODY, LA
TI INTERMEDIATE BIOMARKERS OF PRECANCER AND THEIR APPLICATION IN
   CHEMOPREVENTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE CHEMOPREVENTION; CLINICAL TRIAL; DRUG DEVELOPMENT; INTERMEDIATE
   BIOMARKER
ID CANCER PREVENTION; END-POINTS; ISOTRETINOIN; AGENTS; TRIALS
AB The Chemoprevention Branch of the National Cancer institute has established a program for the development of safe and effective cancer chemopreventive agents. This program includes identification of new agents, testing for efficacy in vitro and in animals, studies in animals to model clinical use, and preclinical toxicity and metabolism evaluation. Ultimately, the most promising agents progress to clinical trials. The long period required for cancer onset presents a significant challenge to the design of clinical trials for chemoprevention. Phase III trials in which cancer reduction is the endpoint require large subject groups (tens of thousands) and follow-up duration of more than five years. Because of these requirements, the costs of such trials are high. The Chemoprevention Branch is addressing this challenge by expansion of the preclinical and Phase II clinical efficacy efforts to include intermediate biomarkers of carcinogenesis as study endpoints.
   The Chemoprevention Branch's studies focus on the development of biomarkers with high reliability and predictive value for cancer. Both single markers and batteries of complementary and parallel markers are evaluated. Among the criteria for biomarkers for chemoprevention studies are the following: (1) differential expression in normal and high risk tissue, (2) appearance early in carcinogenesis (the earlier a reliable biomarker appears, the greater is the chance for successful intervention with a chemopreventive agent), (3) high sensitivity, specificity, and accuracy relative to cancer, (4) ease of measurement (use of non-invasive techniques and small tissue samples is preferable), (5) demonstration of modulation by chemopreventive agents, and (6) correlation of modulation with decreased cancer incidence.
C1 CCS ASSOCIATES,PALO ALTO,CA 94301.
RP KELLOFF, GJ (reprint author), NCI,DIV CANC PREVENT & CONTROL,CHEMOPREVENT BRANCH,BETHESDA,MD 20892, USA.
NR 23
TC 6
Z9 6
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16G
BP 15
EP 21
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA JY991
UT WOS:A1992JY99100002
ER

PT J
AU BOONE, CW
   KELLOFF, GJ
   STEELE, VE
AF BOONE, CW
   KELLOFF, GJ
   STEELE, VE
TI THE NATURAL-HISTORY OF INTRAEPITHELIAL NEOPLASIA - RELEVANCE TO THE
   SEARCH FOR INTERMEDIATE END-POINT BIOMARKERS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE BIOMARKERS; CHEMOPREVENTION; CLONAL EVOLUTION; DYSPLASIA; GENOMIC
   INSTABILITY; INTERMEDIATE BIOMARKER; INTERMEDIATE END-POINT BIOMARKER;
   INTRAEPITHELIAL NEOPLASIA; PRECANCEROUS
ID INTRA-EPITHELIAL NEOPLASIA; COLORECTAL ADENOMAS; ORAL LEUKOPLAKIA;
   FLOW-CYTOMETRY; DNA-ANALYSIS; POLYPOSIS; SULINDAC; CLASSIFICATION;
   ANEUPLOIDY; DYSPLASIA
AB The development of carcinomas, defined as invasive epithelial neoplasms, is preceded by a preinvasive stage termed intraepithelial neoplasia that typically lasts for years. Intraepithelial neoplasia is the target tissue for the action of chemopreventive agents and the site where biomarkers frequently develop. The term "dysplasia" refers to the morphological alterations that characterize intraepithelial neoplasia and, according to many authors, consists of seven basic changes that are the same for the majority of epithelia. These are increased nuclear size, abnormal nuclear shape, increased nuclear stain uptake, nuclear pleomorphism (increased variation in size, shape, and stain uptake), increased mitoses, abnormal mitoses, and disordered or absent differentiation. Clonal evolution appears to begin early in the neoplastic process during intraepithelial neoplasia. The use of intraepithelial neoplasia as an intermediate endpoint biomarker requires that effective chemopreventive agents cause it to regress. Two examples are the regression of dysplastic oral leukoplakia produced by beta-carotene and the regression of colonic polyps in familial polyposis patients following treatment with the nonsteroidal antiinflammatory drug sulindac. There is a critical need to identify and develop biomarkers that correlate with the appearance and regression of intraepithelial neoplasia.
RP BOONE, CW (reprint author), NCI,DIV CANC PREVENT & CONTROL,CHEMOPREVENT BRANCH,BETHESDA,MD 20892, USA.
NR 38
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16G
BP 23
EP 26
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA JY991
UT WOS:A1992JY99100003
ER

PT J
AU FREEDMAN, LS
   SCHATZKIN, A
   SCHIFFMAN, MH
AF FREEDMAN, LS
   SCHATZKIN, A
   SCHIFFMAN, MH
TI STATISTICAL VALIDATION OF INTERMEDIATE MARKERS OF PRECANCER FOR USE AS
   END-POINTS IN CHEMOPREVENTION TRIALS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE CAUSAL RELATIONSHIPS; CHEMOPREVENTION; INTERMEDIATE BIOMARKER; MARKER
   VALIDATION; PHASE-II TRIALS; PHASE-III TRIALS
ID END-POINTS; CANCER; RISK
AB Using an intermediate marker of precancer as an endpoint for evaluating agents that may prevent cancer involves a presumption that the modification of the marker will be accompanied by a modification of cancer incidence. This presumption can hold only if the marker is on or very closely linked to a causal pathway. Epidemiologists have discussed the nature of evidence required to infer causal relationships, and we briefly survey their work. Studies relating exposure (E) to marker (M) provide only indirect evidence for causality. Those relating marker (M) to disease (D) are more relevant. We propose a new validation criterion based on an analysis of the three-way relationship of exposure (E), marker (M) and disease (D). We discuss the level of evidence required for using intermediate markers as endpoints for Phase II and Phase III trials, and propose very stringent criteria for Phase III trials. For Phase II trials, we propose less stringent criteria, but still recommend that the marker (M) should have been shown to have a strong association with disease (D).
C1 NCI,DIV CANC PREVENT,BETHESDA,MD 20892.
   NCI,DIV CANC ETIOL,BETHESDA,MD 20892.
RP FREEDMAN, LS (reprint author), NCI,DIV CANC PREVENT & CONTROL,BIOMETRY BRANCH,EXECTUT PLAZA N,BETHESDA,MD 20892, USA.
NR 9
TC 0
Z9 1
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16G
BP 27
EP 32
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA JY991
UT WOS:A1992JY99100004
ER

PT J
AU THOMPSON, TC
   TRUONG, LD
   TIMME, TL
   KADMON, D
   MCCUNE, BK
   FLANDERS, KC
   SCARDINO, PT
   PARK, SH
AF THOMPSON, TC
   TRUONG, LD
   TIMME, TL
   KADMON, D
   MCCUNE, BK
   FLANDERS, KC
   SCARDINO, PT
   PARK, SH
TI TRANSFORMING GROWTH-FACTOR BETA-1 AS A BIOMARKER FOR PROSTATE-CANCER
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE BIOMARKERS OF PROSTATE CANCER; TGF-BETA-1
ID MYC PROTOONCOGENE; GENE-EXPRESSION; TGF-BETA; FACTOR-BETA-1;
   KERATINOCYTES; INHIBITION; CELLS; CARCINOMA; PROTEIN; DIFFERENTIATION
AB Using the mouse prostate reconstitution (MPR) model system, under conditions where the ras and myc oncogenes are introduced via a recombinant retrovirus into both the mesenchymal and epithelial compartments of the urogenital sinus, poorly differentiated prostate cancer is produced with high frequency (>90%) using inbred C57BL/6 mice. Northern blotting and immunohistochemical analysis showed that the transition from benign prostatic hyperplasia (BPH) to prostate cancer is invariably associated with the induction of elevated transforming growth factor-beta1 (TGF-beta1) expression. Similar analysis of TGF-beta1 in human BPH and prostate cancer is consistent with our MPR results and indicates that the accumulation of extracellular TGF-beta1 is significantly more intense in prostate cancer compared to normal or benign prostate tissues. Interestingly, where benign pathologies are observed in the prostatic stroma in the presence of benign prostatic epithelium, extracellular TGF-beta1 is seen predominantly in the stromal compartment. Experimental studies clearly demonstrate that mRNA levels of TGF-beta1 and other growth related genes are regulated by androgens in prostate cancer cells. Overall, our results suggest that elevated TGF-beta1 is involved in the development of prostate cancer. Direct determination of TGF-beta1 levels and distribution as well as analysis of localized and systemic effects produced by TGF-beta1 may serve as useful biomarkers for prostate cancer.
C1 BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030.
   BAYLOR COLL MED,DEPT PATHOL,HOUSTON,TX 77030.
   NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
RP THOMPSON, TC (reprint author), BAYLOR COLL MED,SCOTT DEPT UROL,HOUSTON,TX 77030, USA.
NR 40
TC 1
Z9 1
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16H
BP 54
EP 61
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KK164
UT WOS:A1992KK16400011
ER

PT J
AU HEMSTREET, GP
   RAO, JY
   HURST, RE
   BONNER, RB
   JONES, PL
   VAIDYA, AM
   FRADET, Y
   MOON, RC
   KELLOFF, GJ
AF HEMSTREET, GP
   RAO, JY
   HURST, RE
   BONNER, RB
   JONES, PL
   VAIDYA, AM
   FRADET, Y
   MOON, RC
   KELLOFF, GJ
TI INTERMEDIATE END-POINT BIOMARKERS FOR CHEMOPREVENTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE BLADDER CANCER; CHEMOPREVENTION; F-ACTIN; G-ACTIN; INTERMEDIATE
   BIOMARKER; INTERMEDIATE END-POINT BIOMARKER
ID FLUORESCENCE IMAGE-ANALYSIS; F-ACTIN LEVELS; BLADDER-CANCER; MOLECULAR
   EPIDEMIOLOGY; HIGH-RISK; CELLULAR-TRANSFORMATION; MONOCLONAL-ANTIBODIES;
   ONCOGENE PROTEINS; MARKER; CARCINOGENESIS
AB The understanding of intermediate endpoint biomarker expression in relation to the sequential events in bladder tumorigenesis establishes a useful approach for evaluating chemopreventive agents. Biomarkers may be genotypic or phenotypic and function as biomarkers of susceptibility, exposure, effect, or disease. This paper reviews several years of research on biomarkers and their use in monitoring chemoprevention therapy. In initial animal experiments, mice were dosed with N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) while co-administering N-(4-hydroxyphenyl)retinamide (4-HPR). 4-HPR did not statistically reduce tumor incidence, but did affect tumor differentiation and, consequently, nuclear size and DNA ploidy. These results suggest that nuclear size and ploidy may function as intermediate endpoint biomarkers of effect for oncogenesis and that epigenetic as well as genetic mechanisms may be primary in the oncogenic process. Early biomarkers of effect which occur prior to genetic effects or chromosome aberration may portend a higher probability of being modulated by differentiating agents such as retinoids. In vitro studies demonstrated that RPMI-7666 cells cultured with a phorbol ester tumor promoter (12-O-tetradecanoyl-phorbol-13-acetate) could be redifferentiated with 13-cis-retinoic acid and dimethyl sulfoxide (DMSO). F-actin, a cytoskeletal biomarker with a presumed function in the epigenetic mechanisms of carcinogenesis, could also be normalized in HL-60 cells treated with 4-HPR or DMSO.
   A clinical evaluation of F-actin in patients with varying degrees of risk confirmed the value of F-actin as a differentiating biomarker useful for bladder cancer risk assessment. The clarification of when the phenotypic changes of F-actin occur in the oncogenic process was achieved when a variety of biochemical changes were mapped in the patients with bladder cancer. These studies confirmed that G-actin, a reciprocal form of F-actin, is increased relatively early in bladder cancer oncogenesis when multiple biomarkers are quantitated in the field, adjacent area, and the tumor. Comparison of each individual biomarker's expression from field, adjacent to tumor, and tumor, and subsequent cluster analysis of these biomarkers, indicated that the possible sequence of phenotypic expression of biomarkers in bladder cancer oncogenesis is from G-actin, to p300 antigen, to epidermal growth factor receptor (EGFR), to p185 (neu oncogene product), to DNA aneuploidy and, finally, to visual morphology. To date, a battery of three biomarkers, G-actin, M344, and DNA, with routine cytology has been used to monitor eleven patients receiving Bacillus Calmette-Guerin (BCG) immunotherapy and eight patients clinically free of bladder cancer (negative cytology and biopsy) who were treated with the differentiation agent, DMSO. These results indicate that G-actin may be a useful biomarker for evaluating the efficacy of chemopreventive agents.
C1 UNIV OKLAHOMA,HLTH SCI CTR,DEPT UROL,OKLAHOMA CITY,OK 73190.
   UNIV OKLAHOMA,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,OKLAHOMA CITY,OK 73190.
   UNIV OKLAHOMA,HLTH SCI CTR,DEPT ENVIRONM HLTH,OKLAHOMA CITY,OK 73190.
   UNIV LAVAL,CANC RES CTR,QUEBEC CITY G1K 7P4,QUEBEC,CANADA.
   UNIV OKLAHOMA,HLTH SCI CTR,DEPT BIOCHEM & MOLEC BIOL,OKLAHOMA CITY,OK 73190.
   UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL,OKLAHOMA CITY,OK 73190.
   IIT,RES INST,CHICAGO,IL 60616.
   NCI,CHEMOPREVENT BRANCH,BETHESDA,MD 20892.
OI Hurst, Robert/0000-0003-0370-1817
NR 47
TC 3
Z9 3
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16I
BP 93
EP 110
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KV875
UT WOS:A1992KV87500019
ER

PT J
AU CHUNG, LWK
   LI, W
   GLEAVE, ME
   HSIEH, JT
   WU, HC
   SIKES, RA
   ZHAU, HE
   BANDYK, MG
   LOGOTHETIS, CJ
   RUBIN, JS
   VONESCHENBACH, AC
AF CHUNG, LWK
   LI, W
   GLEAVE, ME
   HSIEH, JT
   WU, HC
   SIKES, RA
   ZHAU, HE
   BANDYK, MG
   LOGOTHETIS, CJ
   RUBIN, JS
   VONESCHENBACH, AC
TI HUMAN PROSTATE-CANCER MODEL - ROLES OF GROWTH-FACTORS AND EXTRACELLULAR
   MATRICES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE EXTRACELLULAR MATRICES (ECMS); BFGF; NGF; HGF AND KGF; GROWTH FACTORS
   (GFS); HUMAN PROSTATE CANCER MODEL; PROSTATE CANCER-BONE INTERACTION;
   STROMAL-EPITHELIAL INTERACTION
ID FIBROBLASTS; CELLS; PROTEIN; ACCELERATION; TENASCIN; INVIVO
AB A human prostate cancer model was established by inoculating a prostate specific antigen (PSA)-producing LNCaP cell line with either prostate or bone fibroblasts. Alternatively, this human prostate cancer model can also be established by inoculating LNCaP cells with growth factor(s) (GFs) and extracellular matrix (ECM) immobilized on Gelfoam(R). The resulting LNCaP tumors were used to evaluate PSA production and excretion in athymic hosts. This model was also employed to examine the biochemical nature of mesenchymal cell-derived growth-promoting protein(s) and to assess the efficacy of potential chemotherapeutic agents. Because of the propensity of human prostate cancer to metastasize to the bone, this study defined a 1.0 M NaCl-eluted fraction, MS1, from the conditioned medium of a bone stromal cell line (MS) by heparin-affinity column chromatography. The growth-promoting activity was assayed both in vivo (e.g., tumor formation) and in vitro (e.g., soft agar colony formation). We found that the growth-promoting activity was trypsin- and heat-sensitive, and partially degraded by acid and dithiothreitol. Immunochemical studies indicated that the polyclonal antibody raised against MS1 blocked the growth-promoting effect elicited by the bone-conditioned media. This growth-promoting factor was found to be immunochemically dissimilar to KGF, HGF, and bFGF. However, addition of bFGF, HGF and NGF, but not aFGF, TGFbeta, IGF1, IGF2, PDGF, EGF, TGFalpha and KGF, stimulated anchorage-independent growth of prostate cells, a condition closely parallel to tumor formation in vivo. We found that the MS1 fraction also contained fibronectin and tenascin but not laminin or collagen IV. None of the ECM proteins induced soft agar colony formation by normal prostate epithelial cells. Therefore, it is possible that the ECM protein(s) may potentiate the tumor-inducing activity of locally produced GFs.
C1 NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892.
RP CHUNG, LWK (reprint author), UNIV TEXAS,MD ANDERSON CANC CTR,DEPT UROL & MED ONCOL,HOUSTON,TX 77030, USA.
NR 15
TC 2
Z9 2
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16H
BP 99
EP 105
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KK164
UT WOS:A1992KK16400021
ER

PT J
AU WILLIAMS, RD
   BOSTWICK, DG
   BOONE, CW
   CATALONA, WJ
   MCKEEHAN, W
   THOMPSON, IM
AF WILLIAMS, RD
   BOSTWICK, DG
   BOONE, CW
   CATALONA, WJ
   MCKEEHAN, W
   THOMPSON, IM
TI WHEN IS INTERVENTION WARRANTED
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Editorial Material
C1 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,ROCHESTER,MN 55905.
   NCI,CHEMOPREVENT BRANCH,BETHESDA,MD 20892.
   WASHINGTON UNIV,SCH MED,DIV UROL SURG,ST LOUIS,MO 63110.
   W ALTON JONES CELL SCI CTR,LAKE PLACID,NY 12949.
   BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234.
RP WILLIAMS, RD (reprint author), UNIV IOWA,COLL MED,DEPT UROL,IOWA CITY,IA 52242, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16H
BP 138
EP 139
PG 2
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KK164
UT WOS:A1992KK16400030
ER

PT J
AU CRAWFORD, ED
   FAIR, WR
   KELLOFF, GJ
   LIEBER, MM
   MILLER, GJ
   SCARDINO, PT
   DEANTONI, EP
AF CRAWFORD, ED
   FAIR, WR
   KELLOFF, GJ
   LIEBER, MM
   MILLER, GJ
   SCARDINO, PT
   DEANTONI, EP
TI CHEMOPREVENTION OF PROSTATE-CANCER - GUIDELINES FOR POSSIBLE
   INTERVENTION STRATEGIES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Editorial Material
DE BIOMARKERS; CHEMOPREVENTION; PREMALIGNANCY; PROSTATE; RANDOMIZED TRIALS;
   RISK STRATIFICATION
ID PREVENTION TRIALS; CLINICAL-TRIALS; DESIGNS; ISSUES; AGENTS
AB The ''natural history'' of prostate cancer may bedevil the development of guidelines for chemoprevention interventions. Can strategies be designed to direct agents to those lesions which have the potential to develop localized extension that may become symptomatic or metastatic disease? Of necessity our interventions will focus on the identification and quantification of appropriate biomarkers as intermediate endpoints, although no reliable endpoints for prostate cancer have yet been identified. The reduction of prostate cancer incidence may be the ultimate objective, but a decrease in the progression of microfocal or ''latent'' cancer may well be just as effective as prevention when the age of the target population and competing causes of death are taken into account. Early intervention strategies must focus on the analysis of the interactions of the chosen chemopreventive agents upon precancerous and cancerous cellular dynamics in the prostate. Whether the requirements of such molecular epidemiology necessitate a more deliberate strategy of Phase II studies or a high risk-high gain strategy of a broad Phase III study is open to debate. Factorial designs for proposed randomized chemoprevention trials may be desirable to test multiple chemopreventive agents simultaneously, provided knowledge of the biochemical synergism of the agents is solid. Stratification of study participants by degree of risk will ameliorate concerns regarding the precision targeting of lesions at different stages in the precancer/cancer continuum.
C1 MEM SLOAN KETTERING CANC CTR,UROL SURG SERV,NEW YORK,NY 10021.
   NCI,CHEMOPREVENT BRANCH,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892.
   MAYO CLIN & MAYO FDN,DEPT UROL,ROCHESTER,MN 55905.
   UNIV COLORADO,HLTH SCI CTR,DEPT PATHOL,DENVER,CO 80262.
   BAYLOR COLL MED,DEPT UROL,HOUSTON,TX 77030.
RP CRAWFORD, ED (reprint author), UNIV COLORADO,HLTH SCI CTR,DIV UROL,DENVER,CO 80262, USA.
NR 28
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16H
BP 140
EP 145
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KK164
UT WOS:A1992KK16400031
ER

PT J
AU BOONE, CW
AF BOONE, CW
TI BIOMARKERS IN OTHER TARGET SITES - OVERVIEW
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Editorial Material
RP BOONE, CW (reprint author), NCI,DIV CANC CHEMOPREVENT & CONTROL,CHEMOPREVENT BRANCH,BETHESDA,MD 20892, USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16G
BP 159
EP 160
PG 2
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA JY991
UT WOS:A1992JY99100026
ER

PT J
AU SHEINFELD, J
   HERR, HW
   BOONE, CW
   BOSTWICK, DG
   CLARK, LC
   DECENSI, AU
   WHITE, RWD
   FARROW, GM
   FRADET, Y
   GROSSMAN, HB
   HEMSTREET, GP
   KELLOFF, GJ
   KOSS, LG
   LOGOTHETIS, CJ
   LOPRINZI, CL
   MELAMED, MR
   PROUT, G
   REUTER, V
   SOLOWAY, MS
   VONESCHENBACH, AC
   WHITMORE, WF
AF SHEINFELD, J
   HERR, HW
   BOONE, CW
   BOSTWICK, DG
   CLARK, LC
   DECENSI, AU
   WHITE, RWD
   FARROW, GM
   FRADET, Y
   GROSSMAN, HB
   HEMSTREET, GP
   KELLOFF, GJ
   KOSS, LG
   LOGOTHETIS, CJ
   LOPRINZI, CL
   MELAMED, MR
   PROUT, G
   REUTER, V
   SOLOWAY, MS
   VONESCHENBACH, AC
   WHITMORE, WF
TI INTERVENTION STRATEGIES FOR CHEMOPREVENTION OF BLADDER-CANCER
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Editorial Material
C1 MEM SLOAN KETTERING CANC CTR,DEPT UROL,NEW YORK,NY 10021.
   NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892.
   MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,ROCHESTER,MN 55905.
   UNIV ARIZONA,COLL MED,TUCSON,AZ 85716.
   IST NAZL RIC CANC,I-16132 GENOA,ITALY.
   UNIV CALIF DAVIS,SACRAMENTO MED CTR,MED CTR,SACRAMENTO,CA 95817.
   MAYO CLIN & MAYO FDN,DEPT PATHOL,ROCHESTER,MN 55905.
   LAVAL UNIV,CANC RES CTR,QUEBEC CITY G1R 2J6,PQ,CANADA.
   UNIV MICHIGAN,ANN ARBOR,MI 48109.
   UNIV OKLAHOMA,HLTH SCI CTR,DEPT UROL,OKLAHOMA CITY,OK 73104.
   YESHIVA UNIV ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,BRONX,NY 10461.
   UNIV TEXAS,MD ANDERSON CANC CTR,HOUSTON,TX 77030.
   NEW YORK MED COLL,VALHALLA,NY 10595.
   UNIV MIAMI,SCH MED,MIAMI,FL 33136.
RP SHEINFELD, J (reprint author), MEM SLOAN KETTERING CANC CTR,DEPT SURG,UROL SERV,NEW YORK,NY 10021, USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16I
BP 173
EP 174
PG 2
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA KV875
UT WOS:A1992KV87500031
ER

PT J
AU MULSHINE, JL
   LINNOILA, RI
   TRESTON, AM
   SCOTT, FM
   QUINN, K
   AVIS, I
   SHAW, GL
   JENSEN, SM
   BROWN, P
   BIRRER, MJ
   CUTTITTA, F
AF MULSHINE, JL
   LINNOILA, RI
   TRESTON, AM
   SCOTT, FM
   QUINN, K
   AVIS, I
   SHAW, GL
   JENSEN, SM
   BROWN, P
   BIRRER, MJ
   CUTTITTA, F
TI CANDIDATE BIOMARKERS FOR APPLICATION AS INTERMEDIATE END-POINTS OF LUNG
   CARCINOGENESIS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE CARCINOGENESIS; CHEMOPREVENTION; INTERMEDIATE END POINT; BIOMARKERS;
   DIFFERENTIATION; GROWTH FACTORS; LUNG CANCER
ID TRIALS
AB The need for validated intermediate end point markers to facilitate lung cancer chemointervention research is compelling. Three major classes of lung markers are relevant for this application. Since lung cancer includes four distinct histologies, markers that map degrees of histologic differentiation are important. Many of the markers for squamous differentiation overlap with the candidates for application in the study of head and neck cancer. Production of tissue-specific cell products especially for surfactant or CEA is of interest, because the gene structure is known and many differentiation-related polymorphisms exist. This strategy would be useful for adenomatous type tissue. A second type of marker is the broad group of differentiation markers. The carbohydrate or blood group-like antigens comprise a representative example. Carbohydrate structures are expressed in a specific sequence during fetal processes, and this sequence appears to reverse with the development of a cancer. Retro differentiation of specific differentiation markers is the basis of a major effort to effect earlier lung cancer detection using sputum immunocytochemistry. The final class includes markers which affect either positive or negative aspects of growth. Candidates in this area include growth factors or their receptors, or genes that regulate growth. If the intermediate end point marker reflects tumor biology and that biology is in the causal path of tumor progression, serial observation of that parameter should indicate the success of the intervention. In all three of these examples, the clinical material to be analyzed could be sputum specimens, bronchial biopsies or resected lung tissue. Systematic analysis of these markers in context of intervention trials is required to validate their utility. Long term clinical follow-up will demonstrate the degree of concordance between biomarkers and more traditional clinical trial end points and will establish if such tools can play a role in catalyzing the rate of prevention research.
RP MULSHINE, JL (reprint author), NCI,DIV CANC PREVENT & CONTROL,BIOMARKERS & PREVENT RES BRANCH,BETHESDA,MD 20892, USA.
NR 13
TC 0
Z9 0
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PY 1992
SU 16G
BP 183
EP 186
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA JY991
UT WOS:A1992JY99100030
PM 1389692
ER

PT J
AU WALDBILLIG, RJ
   SCHOEN, TJ
   CHADER, GJ
   PFEFFER, BA
AF WALDBILLIG, RJ
   SCHOEN, TJ
   CHADER, GJ
   PFEFFER, BA
TI MONKEY RETINAL-PIGMENT EPITHELIAL-CELLS INVITRO SYNTHESIZE, SECRETE, AND
   DEGRADE INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
ID HUMAN AMNIOTIC-FLUID; IGF-I; EXPRESSION; PLASMA; PURIFICATION; COMPLEX;
   CLONING; FORMS
AB Cultured monkey retinal pigment epithelial (RPE) cells rapidly secrete large amounts of insulin-like growth factor binding proteins (IGF-BPs).  IGF-II tracer binding activity in conditioned media is two to three times greater than that of IGF-I.  Under reducing SDS-PAGE conditions, I-125-IGF affinity-crosslinked binding protein (BP) is visualized as a broad band between 36 +/- 2.9 and 49 +/- 3.3 kDa.  Because the electrophoretic mobility of the crosslinked BP is increased under non-reducing conditions (33-45 kDa), intramolecular sulfhydryl bonding may be present.  Frequently, the radiographic band representing affinity-crosslinked binding protein exhibits a complex pattern of non-uniform densities that suggests structural or functional IGF-BP micro-heterogeneity.  IGF-BPs synthesized by RPE also exhibit heterogeneity with respect to the absence or presence of oligosaccharide side chains.  In particular, the larger, but not the mid-sized or smaller IGF-BPs exhibit side chains linked to the core protein with N-glycosidic linkage.  None of the crosslinked IGF-BPs exhibit O-linked side chains.  Long-term (12, 24, 48 hr) conditioning studies revealed that IGF-BP fails to accumulate in culture media beyond 12 hr, but that replacement of conditioned media with fresh media allows a second period of binding protein accumulation.  Other short-term (12 hr) experiments indicate that, in fresh medium, the levels of IGF-BP increase during the first 6-8 hr and then remain stable.  To examine the processes contributing to these steady state levels of IGF-BP, aliquots of 8-hr conditioned medium were removed from the cells and either frozen on dry ice or incubated at 37-degrees-C for 16 hr.  Importantly, it was found that incubation at 37-degrees-C resulted in a near total loss of binding activity.  This is the first report of IGF-BP degrading activity in a cell culture system.  These findings indicate that 1) primate RPE cells rapidly secrete a complex mixture of N-glycosylated and non-glycosylated IGF-BPs, and 2) the steady state levels of secreted IGF-BP are tightly regulated at least in part through a concomitant IGF-BP inactivating activity.  Cultured RPE cells may be of utility in examining the mechanisms of IGF-BP synthesis, secretion, and degradation at the cellular level.
C1 NEI,MECHANISMS OCULAR DIS LAB,BETHESDA,MD 20892.
RP WALDBILLIG, RJ (reprint author), NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892, USA.
NR 22
TC 19
Z9 19
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0021-9541
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JAN
PY 1992
VL 150
IS 1
BP 76
EP 83
DI 10.1002/jcp.1041500111
PG 8
WC Cell Biology; Physiology
SC Cell Biology; Physiology
GA GZ889
UT WOS:A1992GZ88900010
PM 1370504
ER

PT J
AU DIAS, JR
   MILNE, GWA
AF DIAS, JR
   MILNE, GWA
TI CHEMICAL APPLICATIONS OF GRAPH-THEORY
SO JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
LA English
DT Editorial Material
C1 NIH,BETHESDA,MD 20892.
RP DIAS, JR (reprint author), UNIV MISSOURI,COLUMBIA,MO 65201, USA.
NR 0
TC 3
Z9 3
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036
SN 0095-2338
J9 J CHEM INF COMP SCI
JI J. Chem. Inf. Comput. Sci.
PD JAN-FEB
PY 1992
VL 32
IS 1
BP 1
EP 1
DI 10.1021/ci00005a600
PG 1
WC Chemistry, Multidisciplinary; Computer Science, Information Systems;
   Computer Science, Interdisciplinary Applications
SC Chemistry; Computer Science
GA HB741
UT WOS:A1992HB74100001
ER

PT J
AU GROLLMAN, EF
   DOI, SQ
   WEISS, P
   ASHWELL, G
   WAJCHENBERG, BL
   MEDEIROSNETO, G
AF GROLLMAN, EF
   DOI, SQ
   WEISS, P
   ASHWELL, G
   WAJCHENBERG, BL
   MEDEIROSNETO, G
TI HYPOSIALYLATED THYROGLOBULIN IN A PATIENT WITH CONGENITAL GOITER AND
   HYPOTHYROIDISM
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE; TISSUE-SPECIFIC
   EXPRESSION; RAT THYROID TUMOR; TRANSCRIPTIONAL REGULATION; SIALIC-ACID;
   IODINATION; GENE
AB A large family (14 children) with congenital goiter whose parents are first cousins was studied. Thyroid tissue was obtained, after I-125 in vivo labeling, from one of the siblings (JBM). Gel filtration of thyroid proteins indicated that thyroglobulin (Tg) eluted as a single symmetrical peak in the same position as authentic 19S Tg. Gel electrophoresis in a 7.5% sodium dodecyl sulfate-polyacrylamide gel revealed a major band with the same mobility and immunoreactivity as normal 19S Tg. Hydrolysis of the patient's Tg indicated that most of the radioactivity was mono- and diiodotyrosines. The yield of T4 from JBM Tg (26 pmol/mg protein) was 5-fold less than normal thyroid tissue (140 pmol/mg protein) and approximately half of that in thyroid tissue from endemic goiter (51 pmol/mg). Total T3 released from JBM Tg was similar to the other two tissues. When the carbohydrate content of normal and patient Tg was analyzed, there was no differences in glucosamine, galactose or mannose content. However, unlike normal and endemic-goiter Tg, that had a mean sialic acid content of 7.3 and 5.6-mu-g/mg protein, respectively, the sialic acid concentration of the patients Tg was only 0.3-mu-g/mg. Sialyltransferase activity was readily demonstrated in homogenate from normal thyroid or endemic goiter, but no sialyltransferase activity was detectable in a homogenate of JBM-thyroid tissue. We conclude that the finding of severely hyposialylated Tg is linked to a defect in iodotyrosine coupling seen in this patient with a possibly abnormal migration of Tg into the follicular lumen.
C1 UNIV SAO PAULO, HOSP CLIN, SCH MED, DIV ENDOCRINOL, SAO PAULO, BRAZIL.
RP GROLLMAN, EF (reprint author), NIDDKD, BIOCHEM & METAB LAB, BLDG 10, RM 9B12, BETHESDA, MD 20892 USA.
NR 26
TC 26
Z9 26
U1 0
U2 0
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 1992
VL 74
IS 1
BP 43
EP 48
DI 10.1210/jc.74.1.43
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HD949
UT WOS:A1992HD94900010
PM 1727828
ER

PT J
AU BLOCH, B
   GAILLARD, RC
   CULLER, MD
   NEGROVILAR, A
AF BLOCH, B
   GAILLARD, RC
   CULLER, MD
   NEGROVILAR, A
TI IMMUNOHISTOCHEMICAL DETECTION OF PROLUTEINIZING HORMONE-RELEASING
   HORMONE PEPTIDES IN NEURONS IN THE HUMAN HYPOTHALAMUS
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID IMMUNOCYTOCHEMICAL LOCALIZATION; LHRH PRECURSOR; RAT; PROHORMONE;
   SECRETION; SYSTEM; GENE; CDNA; GAP
AB To determine the presence of LHRH prohormone products in the human hypothalamus, antisera raised against LHRH and GnRH-associated peptide (GAP) were used to search for the presence of the corresponding antigens in the human adult and fetal hypothalamus by an immunohistochemical approach. The comparison of immunostaining on adjacent sections shows that all of the cells labeled with LHRH antiserum are also labeled with GAP antiserum and vice versa. Labeled cells are detectable during the 9th week of fetal life, this being the earliest time evaluated. At this time, the LHRH/GAP-positive cells frequently have a neuroblastic appearance. The first detectable fibers appear during the 11th week, and these were observed in the lamina terminalis cinerea and median eminence. In the adult brain, fibers and endings labeled with LHRH or GAP antiserum in the median eminence demonstrate the same topography and morphological characteristics, which are distinct from fibers labeled with other neuropeptide antisera. These results show that the LHRH precursor molecule is produced throughout life in the human hypothalamus, including the earliest stages of development of the peptidergic neurons. Moreover, the detection of LHRH- and GAP-positive fibers in the median eminence by the 11th week of fetal life suggests the possibility of an early role of LHRH and, possibly, other LHRH prohormone-derived peptides in the development of anterior pituitary function during the fetal period.
C1 NIEHS, REPROD NEUROENDOCRINOL SECT, MOLEC & INTEGRAT NEUROSCI LAB, RES TRIANGLE PK, NC 27709 USA.
   UNIV BORDAUX 2, HISTOL EMBRYOL LAB, CNRS, URA 1200, F-33077 BORDEAUX, FRANCE.
   HOP CANTONAL GENEVA, MED KLIN, CH-1211 GENEVA 4, SWITZERLAND.
NR 19
TC 13
Z9 13
U1 0
U2 1
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 1992
VL 74
IS 1
BP 135
EP 138
DI 10.1210/jc.74.1.135
PG 4
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA HD949
UT WOS:A1992HD94900024
PM 1727812
ER

PT J
AU SAMMARITANO, LR
   GHARAVI, AE
   SOBERANO, C
   LEVY, RA
   LOCKSHIN, MD
AF SAMMARITANO, LR
   GHARAVI, AE
   SOBERANO, C
   LEVY, RA
   LOCKSHIN, MD
TI PHOSPHOLIPID BINDING OF ANTIPHOSPHOLIPID ANTIBODIES AND PLACENTAL
   ANTICOAGULANT PROTEIN
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Article
DE ANTIPHOSPHOLIPID ANTIBODY; LUPUS ANTICOAGULANT; PLACENTAL ANTICOAGULANT
   PROTEIN; LIPOCORTIN; PHOSPHOLIPID BINDING
ID SYSTEMIC LUPUS-ERYTHEMATOSUS; ENDOTHELIAL CELL ANTIBODIES;
   ANTICARDIOLIPIN ANTIBODIES; ANTI-CARDIOLIPIN; CONSECUTIVE PATIENTS;
   LIPOCORTIN FAMILY; INHIBITION; ASSOCIATION; COAGULATION; SPECIFICITY
AB We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity in in vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and that in vivo interaction may occur.
C1 NIAMSD,BETHESDA,MD.
RP SAMMARITANO, LR (reprint author), CORNELL UNIV,MED CTR,HOSP SPECIAL SURG,DIV RHEUMAT DIS,535 E 70 ST,NEW YORK,NY 10021, USA.
OI Levy, Roger/0000-0001-6393-6031
FU NIAMS NIH HHS [AR-32929]
NR 62
TC 70
Z9 71
U1 0
U2 0
PU PLENUM PUBL CORP
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013
SN 0271-9142
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD JAN
PY 1992
VL 12
IS 1
BP 27
EP 35
DI 10.1007/BF00918270
PG 9
WC Immunology
SC Immunology
GA GZ445
UT WOS:A1992GZ44500005
PM 1372614
ER

PT J
AU RHIM, SH
   MILLAR, SE
   ROBEY, F
   LUO, AM
   LOU, YH
   YULE, T
   ALLEN, P
   DEAN, J
   TUNG, KSK
AF RHIM, SH
   MILLAR, SE
   ROBEY, F
   LUO, AM
   LOU, YH
   YULE, T
   ALLEN, P
   DEAN, J
   TUNG, KSK
TI AUTOIMMUNE-DISEASE OF THE OVARY INDUCED BY A ZP3-PEPTIDE FROM THE MOUSE
   ZONA-PELLUCIDA
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE OOPHORITIS; PREMATURE OVARIAN FAILURE; T-CELL MEDIATED DISEASE;
   ZONA-PELLUCIDA; ZP3
ID OOCYTE-SPECIFIC EXPRESSION; SPERM RECEPTOR; DEVELOPMENTAL REGULATION;
   THYMECTOMIZED MICE; OOPHORITIS; ANTIBODIES; IMMUNOPATHOLOGY;
   GLYCOPROTEINS; ORCHITIS; FAILURE
AB We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Whereas the peptide induces both T cell and antibody responses, adoptive transfer of CD4+ T cell lines derived from affected animals causes oophoritis without observable antibodies to the zona pellucida peptide. The primacy of the T cell response in the pathogenesis of disease is further substantiated by defining oophoritogenic peptides as small as eight amino acids (Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln) that do not elicit an antibody response to the full-length ZP3 peptide. The identification of a well characterized peptide as a causative agent of autoimmune oophoritis should facilitate understanding of the pathogenesis of this T cell-mediated autoimmune disease. Because the proteins of the zona pellucida are conserved among mammals (the mouse and human ZP3 proteins are 67% identical), this murine model may lead to better understanding of the pathogenesis of human autoimmune oophoritis.
C1 WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV LAB MED,ST LOUIS,MO 63110.
   WASHINGTON UNIV,SCH MED,DEPT MED,DIV LAB MED,ST LOUIS,MO 63110.
   NIDDK,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892.
   NIDR,CELLULAR DEV & ONCOL LAB,BETHESDA,MD 20892.
FU NICHD NIH HHS [HD14504, HD21953]
NR 26
TC 165
Z9 171
U1 0
U2 3
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN
PY 1992
VL 89
IS 1
BP 28
EP 35
DI 10.1172/JCI115572
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA GY561
UT WOS:A1992GY56100004
PM 1370297
ER

PT J
AU FANG, WG
   PIRNIA, F
   BANG, YJ
   MYERS, CE
   TREPEL, JB
AF FANG, WG
   PIRNIA, F
   BANG, YJ
   MYERS, CE
   TREPEL, JB
TI P2-PURINERGIC RECEPTOR AGONISTS INHIBIT THE GROWTH OF
   ANDROGEN-INDEPENDENT PROSTATE CARCINOMA-CELLS
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE SIGNAL TRANSDUCTION; CALCIUM; PHOSPHATIDYLINOSITOL TURNOVER;
   HORMONE-REFRACTORY; ADENINE NUCLEOTIDES
ID HUMAN-TUMOR CELLS; EXTRACELLULAR ATP; ADENOSINE-TRIPHOSPHATE;
   INTRACELLULAR CA-2+; METABOLISM; FLUTAMIDE; TISSUES; CANCER; DEATH;
   ANTIANDROGEN
AB To develop a new approach to the treatment of advanced, hormone-refractory prostate cancer, the signal transductions regulating the growth of human androgen-independent prostate carcinoma cell lines were studied. Agonist-stimulated Ca2+ mobilization, a critical regulatory event in other secretory cell types, was studied as a means of identifying previously undescribed plasma membrane receptors that may transduce a growth inhibitory signal. In all of the cell lines tested, P2-purinergic receptor agonists, including ATP and certain hydrolysis-resistant adenine nucleotides, induced a rapid, transient increase in cytoplasmic free Ca2+ that was detectable at 50 to 100 nM ATP, was maximal at 100-mu-M ATP, and was inhibited approximately 50% by chelation of extracellular Ca2+. Within 8 s after addition, ATP stimulated accumulation of the polyphosphatidylinositol products inositol (1, 4, 5) trisphosphate, inositol (1, 3, 4) trisphosphate, and inositol tetrakisphosphate. In addition to stimulating phosphatidylinositol turnover and Ca2+ mobilization, ATP and hydrolysis-resistant ATP analogues induced > 90% inhibition of the growth of all lines tested. These data demonstrate that human androgen-independent prostate carcinoma cells express functional P2-purinergic receptors linked to phospholipase C, and that agonists of this receptor are markedly growth inhibitory, suggesting a novel therapeutic approach to this common adult neoplasm.
C1 NCI,DIV CANC TREATMENT,CLIN PHARMACOL BRANCH,CLIN ONCOL PROGRAM,BLDG 10,ROOM 12N226,BETHESDA,MD 20892.
RI Bang, Yung Jue/J-2759-2012
NR 38
TC 67
Z9 83
U1 0
U2 1
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN
PY 1992
VL 89
IS 1
BP 191
EP 196
DI 10.1172/JCI115562
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA GY561
UT WOS:A1992GY56100025
PM 1309535
ER

PT J
AU EMANCIPATOR, K
   ELIN, RJ
   FLEISHER, TA
AF EMANCIPATOR, K
   ELIN, RJ
   FLEISHER, TA
TI COMPARISON OF 2 AUTOMATED NEPHELOMETERS
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article
DE IMMUNOGLOBULIN; APOLIPOPROTEIN; COMPLEMENT; ACUTE PHASE REACTANTS;
   ANTITRYPSIN; CERULOPLASMIN; ALBUMIN; C-REACTIVE PROTEIN;
   STANDARDIZATION; PROTEIN ASSAY
AB The intercalibration precision and linearity were determined for two representative analytes, apolipoprotein A1 (apo A1) and immunoglobulin G (IgG), on the Beckman Array(R) and the Behring Nephelometer 100(R) (BN-100). For two of nine samples analyzed, poor precision was observed for IgG with the Array. The poor precision for these two samples is attributed to large systematic shifts. A statistical non-linearity was observed for apo A1 with the BN-100, but this non-linearity does not exclude use of this assay for clinical diagnosis. Method comparisons were done for 12 analytes: apo A1, apo B, IgG, IgA, IgM, IgE, C3, C4, albumin, C-reactive protein, alpha-1-antitrypsin, and ceruloplasmin. These comparisons showed proportional biases of > 10% for seven of 12 analytes. Furthermore, correlation coefficients were <0.96 for seven of 12 analytes. We conclude that comparing results obtained from the two different nephelometers is of only limited value for the individual patient.
C1 NIH,WARREN G MAGNUSON CLIN CTR,DEPT CLIN PATHOL,BETHESDA,MD 20892.
NR 7
TC 7
Z9 7
U1 1
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0887-8013
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PY 1992
VL 6
IS 6
BP 399
EP 404
DI 10.1002/jcla.1860060611
PG 6
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA JU790
UT WOS:A1992JU79000010
PM 1432366
ER

PT J
AU GERNA, G
   SARASINI, A
   PAREA, M
   ARISTA, S
   MIRANDA, P
   BRUSSOW, H
   HOSHINO, Y
   FLORES, J
AF GERNA, G
   SARASINI, A
   PAREA, M
   ARISTA, S
   MIRANDA, P
   BRUSSOW, H
   HOSHINO, Y
   FLORES, J
TI ISOLATION AND CHARACTERIZATION OF 2 DISTINCT HUMAN ROTAVIRUS STRAINS
   WITH G6 SPECIFICITY
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID LINKED IMMUNOSORBENT-ASSAY; RNA-RNA HYBRIDIZATION;
   MONOCLONAL-ANTIBODIES; BOVINE ROTAVIRUSES; SUBGROUP-I; NEUTRALIZATION
   EPITOPES; PORCINE ROTAVIRUS; CELL-CULTURE; SEROTYPE; CHILDREN
AB Two new human rotavirus (HRV) strains, PA151 and PA169, with subgroup I specificity and a long RNA pattern, yet with a serotype G (VP7) specificity different from those of any of the six well-established HRV serotypes (G1 to G4, G8, and G9), were isolated 3 months apart from two children with acute gastroenteritis in Sicily, southern Italy, in the winter season of 1987 and 1988.  The HRV isolates were adapted to growth in cell cultures and were then characterized by neutralization and RNA-RNA (Northern blot) hybridization.  Cross-neutralization studies with type-specific immune sera to RV serotypes 1 to 10 showed the antigenic relatedness of the two strains with serotype 6 bovine strains UK and NCDV.  Monoclonal antibodies to VP7 of UK were able to recognize UK and NCDV strains as well as both HRV isolates.  Cross-hybridization studies showed a genetic relatedness of PA151 and PA169 to bovine strains for all genes except gene 4.  Gene 4 of PA151 appeared to be genetically related to that of AU228 (a human strain of subgroup I and with serotype G3 specificity that belongs to a feline genogroup), whereas gene 4 of PA169 appeared to be unique, yet it was related to gene 4 of two recently reported subgroup I HRV strains, one (PA710) with serotype G3 specificity and the other (HAL1271) with serotype G8 specificity.  The new HRV strains must be taken into consideration when deciding strategies for the development of an effective RV vaccine.
C1 CNR,IST GENET BIOCHIM & EVOLUZIONIST,I-27100 PAVIA,ITALY.
   UNIV PALERMO,INST MICROBIOL,I-90127 PALERMO,ITALY.
   NESTEC LTD,NESTLE RES CTR,CH-1000 LAUSANNE 26,SWITZERLAND.
   NIAID,BETHESDA,MD 20892.
RP GERNA, G (reprint author), UNIV PAVIA,POLICLIN SAN MATTEO,IST RIC & CURA CARATTERE SCI,INST INFECT DIS,VIRUS LAB,I-27100 PAVIA,ITALY.
NR 44
TC 136
Z9 136
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JAN
PY 1992
VL 30
IS 1
BP 9
EP 16
PG 8
WC Microbiology
SC Microbiology
GA GV355
UT WOS:A1992GV35500002
PM 1370851
ER

PT J
AU ZIERDT, CH
   HOSEIN, IK
   SHIVELY, R
   MACLOWRY, JD
AF ZIERDT, CH
   HOSEIN, IK
   SHIVELY, R
   MACLOWRY, JD
TI PHAGE PATTERN-SPECIFIC OXACILLIN-RESISTANT AND BORDERLINE
   OXACILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS IN UNITED-STATES HOSPITALS -
   EPIDEMIOLOGIC SIGNIFICANCE
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Note
ID METHICILLIN RESISTANCE; INFECTIONS; OUTBREAK; STRAINS; EVOLUTION
AB For a 13-year period (1978 through 1990), oxacillin-resistant (MIC, > 4-mu-g/ml) Staphylococcus aureus (ORSA) strains were collected from Clinical Center (National Institutes of Health) patients and patients from five other U.S. hospitals.  From Clinical Center patients, 251 of 253 isolates (99%) were bacteriophage typed as phage group III.  Five other hospitals contributed 203 ORSA strains, of which 188 (93%) were group III.  The group III ORSA strains predominantly included a characteristic core pattern of phages, 7/47/53/54/75/77.  For the low-level (borderline) oxacillin-resistant strains (MIC, 2 to 4-mu-g/ml), amoxicillin-clavulanic acid combination (Augmentin) testing disclosed 62 hyper-beta-lactamase producers, of which 59 (95%) were of a separate, distinct S. aureus strain, with the phage pattern 92/94/96/292/D-11 (group V).  Thus, ORSA and hyper-beta-lactamase producing S. aureus are distinct epidemic strains.
C1 UNIV HOSP JACKSONVILLE,JACKSONVILLE,FL 32209.
   US FDA,ROCKVILLE,MD 20850.
   GRP HLTH ASSOC INC,WASHINGTON,DC 20006.
RP ZIERDT, CH (reprint author), NIH,DEPT CLIN PATHOL,MICROBIOL SERV,BETHESDA,MD 20892, USA.
NR 25
TC 15
Z9 15
U1 1
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JAN
PY 1992
VL 30
IS 1
BP 252
EP 254
PG 3
WC Microbiology
SC Microbiology
GA GV355
UT WOS:A1992GV35500049
PM 1734064
ER

PT J
AU BRASILNETO, JP
   COHEN, LG
   PANIZZA, M
   NILSSON, J
   ROTH, BJ
   HALLETT, M
AF BRASILNETO, JP
   COHEN, LG
   PANIZZA, M
   NILSSON, J
   ROTH, BJ
   HALLETT, M
TI OPTIMAL FOCAL TRANSCRANIAL MAGNETIC ACTIVATION OF THE HUMAN MOTOR CORTEX
   - EFFECTS OF COIL ORIENTATION, SHAPE OF THE INDUCED CURRENT PULSE, AND
   STIMULUS-INTENSITY
SO JOURNAL OF CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE MAGNETIC STIMULATION; MOTOR CORTEX; MAGNETIC COIL; MOTOR EVOKED
   POTENTIALS; BRAIN MAPPING; CORTICAL STIMULATION
ID HUMAN-BRAIN; STIMULATION
AB We studied the effects of coil orientation, stimulus intensity, and shape of the induced current pulse on the amplitudes of motor evoked potentials in the left abductor pollicis brevis of 10 normal adults who had transcranial magnetic stimulation.  The optimal direction of currents induced in the brain is approximately perpendicular to the central sulcus, flowing diagonally from back to front.  The most effective coil orientation depends on the shape of the induced current pulse and, when the first and second phases of the pulse are of similar size, also on the intensity of stimulation.  Optimal mapping of the human motor cortex with magnetic stimulation requires knowledge of the influences of all these factors.
C1 NINCDS,MED NEUROL BRANCH,HUMAN MOTOR CONTROL SECT,HUMAN CORT PHYSIOL UNIT,BLDG 10,BETHESDA,MD 20892.
   NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD.
RI Roth, Bradley/A-4920-2008
NR 19
TC 362
Z9 363
U1 1
U2 19
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0736-0258
J9 J CLIN NEUROPHYSIOL
JI J. Clin. Neurophysiol.
PD JAN
PY 1992
VL 9
IS 1
BP 132
EP 136
DI 10.1097/00004691-199201000-00014
PG 5
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA HB739
UT WOS:A1992HB73900014
PM 1552001
ER

PT J
AU CHABNER, BA
AF CHABNER, BA
TI CAMPTOTHECINS
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Editorial Material
ID DNA TOPOISOMERASE-I; NSC-100880; BREAKS; CELLS
RP CHABNER, BA (reprint author), NIH,BETHESDA,MD 20892, USA.
NR 14
TC 15
Z9 15
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JAN
PY 1992
VL 10
IS 1
BP 3
EP 4
PG 2
WC Oncology
SC Oncology
GA GW592
UT WOS:A1992GW59200002
PM 1727922
ER

PT J
AU WEBER, JS
   YANG, JC
   TOPALIAN, SL
   SCHWARTZENTRUBER, DJ
   WHITE, DE
   ROSENBERG, SA
AF WEBER, JS
   YANG, JC
   TOPALIAN, SL
   SCHWARTZENTRUBER, DJ
   WHITE, DE
   ROSENBERG, SA
TI THE USE OF INTERLEUKIN-2 AND LYMPHOKINE-ACTIVATED KILLER-CELLS FOR THE
   TREATMENT OF PATIENTS WITH NON-HODGKINS-LYMPHOMA
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID TUMOR-INFILTRATING LYMPHOCYTES; ADVANCED CANCER; RECOMBINANT
   INTERLEUKIN-2; ADOPTIVE IMMUNOTHERAPY; PHASE-II; THERAPY; INTERFERON;
   GROWTH; MELANOMA
RP WEBER, JS (reprint author), NCI,SURG BRANCH,BLDG 10,ROOM 2B42,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 31
TC 64
Z9 64
U1 0
U2 1
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JAN
PY 1992
VL 10
IS 1
BP 33
EP 40
PG 8
WC Oncology
SC Oncology
GA GW592
UT WOS:A1992GW59200007
PM 1727923
ER

PT J
AU SPEYER, JL
   GREEN, MD
   ZELENIUCHJACQUOTTE, A
   WERNZ, JC
   REY, M
   SANGER, J
   KRAMER, E
   FERRANS, V
   HOCHSTER, H
   MEYERS, M
   BLUM, RH
   FEIT, F
   ATTUBATO, M
   BURROWS, W
   MUGGIA, FM
AF SPEYER, JL
   GREEN, MD
   ZELENIUCHJACQUOTTE, A
   WERNZ, JC
   REY, M
   SANGER, J
   KRAMER, E
   FERRANS, V
   HOCHSTER, H
   MEYERS, M
   BLUM, RH
   FEIT, F
   ATTUBATO, M
   BURROWS, W
   MUGGIA, FM
TI ICRF-187 PERMITS LONGER TREATMENT WITH DOXORUBICIN IN WOMEN WITH
   BREAST-CANCER
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID CARDIAC TOXICITY; N-ACETYLCYSTEINE; ADRIAMYCIN; CARDIOMYOPATHY;
   CARDIOTOXICITY; PREVENTION
C1 NYU MED CTR,DEPT MED,DIV CARDIOL,NEW YORK,NY 10016.
   NYU MED CTR,INST ENVIRONM MED,EPIDEMIOL & BIOSTAT LAB,NEW YORK,NY 10016.
   RITA & STANELEY KAPLAN CANC CTR,DEPT RADIOL,DIV NUCL MED,NEW YORK,NY.
   NHLBI,ULTRASTRUCT PATHOL BRANCH,BETHESDA,MD 20892.
RP SPEYER, JL (reprint author), NYU MED CTR,DEPT MED,DIV ONCOL,BELLEVUE C & D BLDG,ROOM 556,462 1ST AVE,NEW YORK,NY 10016, USA.
FU NCI NIH HHS [CA-16087]; NCRR NIH HHS [CRC-RR-99]; PHS HHS [36524]
NR 23
TC 259
Z9 262
U1 1
U2 3
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JAN
PY 1992
VL 10
IS 1
BP 117
EP 127
PG 11
WC Oncology
SC Oncology
GA GW592
UT WOS:A1992GW59200018
PM 1727913
ER

PT J
AU BERG, SL
   BALIS, FM
   ZIMM, S
   MURPHY, RF
   HOLCENBERG, J
   SATO, J
   REAMAN, G
   STEINHERZ, P
   GILLESPIE, A
   DOHERTY, K
   POPLACK, DG
AF BERG, SL
   BALIS, FM
   ZIMM, S
   MURPHY, RF
   HOLCENBERG, J
   SATO, J
   REAMAN, G
   STEINHERZ, P
   GILLESPIE, A
   DOHERTY, K
   POPLACK, DG
TI PHASE-I PHASE-II TRIAL AND PHARMACOKINETICS OF INTRATHECAL DIAZIQUONE IN
   REFRACTORY MENINGEAL MALIGNANCIES
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID AZIRIDINYLBENZOQUINONE; HUMANS
C1 CHILDRENS HOSP,LOS ANGELES,CA 90027.
   CHILDRENS HOSP,NATL MED CTR,WASHINGTON,DC 20010.
   MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021.
RP BERG, SL (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,BETHESDA,MD 20892, USA.
NR 16
TC 39
Z9 40
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JAN
PY 1992
VL 10
IS 1
BP 143
EP 148
PG 6
WC Oncology
SC Oncology
GA GW592
UT WOS:A1992GW59200021
PM 1727916
ER

PT J
AU GELERNTER, CS
   STEIN, MB
   TANCER, ME
   UHDE, TW
AF GELERNTER, CS
   STEIN, MB
   TANCER, ME
   UHDE, TW
TI AN EXAMINATION OF SYNDROMAL VALIDITY AND DIAGNOSTIC SUBTYPES IN SOCIAL
   PHOBIA AND PANIC DISORDER
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID ANXIETY DISORDERS; AGORAPHOBIA; INTERVIEW; SYMPTOMS; ATTACKS; FAMILY
AB Background:  We investigated whether patients with DSM-III-R panic disorder and patients with social phobia could be distinguished on the basis of selected demographic variables and by several commonly used anxiety and phobia rating scales.
   Method:  Sixty-six patients with social phobia and 60 patients with panic disorder (42 with and 18 without agoraphobia) were studied. Subjects completed a battery of self-report measures that assessed phobic fears, avoidance, and related problems.
   Results:  Social phobic patients showed an earlier age at onset than the panic disorder group, and there was a trend for more social phobics to have never married. Social phobics reported significantly greater levels of social phobic avoidance and distress, fear of negative evaluation, and avoidance of social situations than the panic disorder patients who reported more overall anxiety and rated themselves as significantly more avoidant of situations involving exposure to public places and to blood or injury. Discriminant function analyses showed that social phobic and panic disorder patients can be reliably discriminated on these scales.
   Conclusion:  The results of this study lend further support for the validity of die DSM-III-R nosologic distinctions between social phobia and panic disorder. Furthermore, generalized social phobia appears to be remarkably different from discrete social phobia on these measures. This study provides less support for considering panic disorder with agoraphobia to be distinct from panic disorder without agoraphobia.
C1 NIMH,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS,BETHESDA,MD 20892.
FU NIMH NIH HHS [T32MH14235]
NR 30
TC 46
Z9 46
U1 0
U2 1
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JAN
PY 1992
VL 53
IS 1
BP 23
EP 27
PG 5
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA HA813
UT WOS:A1992HA81300005
PM 1737736
ER

PT J
AU SHAWKER, TH
   DOPPMAN, JL
   CHOYKE, PL
   FEUERSTEIN, IM
   NIEMAN, LK
AF SHAWKER, TH
   DOPPMAN, JL
   CHOYKE, PL
   FEUERSTEIN, IM
   NIEMAN, LK
TI INTRATESTICULAR MASSES ASSOCIATED WITH ABNORMALLY FUNCTIONING
   ADRENAL-GLANDS
SO JOURNAL OF CLINICAL ULTRASOUND
LA English
DT Article
ID SERTOLI-CELL TUMOR; NODULAR ADRENOCORTICAL DISEASE; ENDOCRINE
   OVERACTIVITY; SPOTTY PIGMENTATION; 21-HYDROXYLASE DEFICIENCY;
   TESTICULAR-TUMORS; COMPLEX; MYXOMAS; TESTIS; HYPERPLASIA
C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20057.
   NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892.
RP SHAWKER, TH (reprint author), NIH,DEPT RADIOL,BLDG 10,ROOM 1C660,BETHESDA,MD 20892, USA.
NR 28
TC 15
Z9 15
U1 0
U2 0
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0091-2751
J9 J CLIN ULTRASOUND
JI J. Clin. Ultrasound
PD JAN
PY 1992
VL 20
IS 1
BP 51
EP 58
DI 10.1002/jcu.1870200110
PG 8
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA GW560
UT WOS:A1992GW56000008
PM 1309544
ER

PT J
AU FRANKEL, RA
   POTTALA, EW
   BOWSER, RW
   BAILEY, JJ
AF FRANKEL, RA
   POTTALA, EW
   BOWSER, RW
   BAILEY, JJ
TI A FILTER TO SUPPRESS ECG BASE-LINE WANDER AND PRESERVE ST-SEGMENT
   ACCURACY IN REAL-TIME ENVIRONMENT
SO JOURNAL OF ELECTROCARDIOLOGY
LA English
DT Article; Proceedings Paper
CT 16TH ANNUAL CONF OF THE INTERNATIONAL SOC FOR COMPUTERIZED
   ELECTROCARDIOLOGY
CY APR 21-26, 1991
CL SANTA BARBARA, CA
SP INT SOC COMP ELECTROCARDIOL, FUKUDA DENSHI AMER, HEWLETT PACKARD, MARQUETTE ELECTR, MORTARA INSTRUMENT, NIHON KOHDEN, PHYSIO CONTROL, QUINTON INSTRUMENT, SCHILLER, SIEMENS ELEMA
C1 NIH,DIV COMP RES & TECHNOL,APPL STUDIES LAB,BETHESDA,MD 20892.
   MED COLL OHIO,DEPT PHYSIOL & BIOPHYS,TOLEDO,OH 43699.
   CREIGHTON UNIV,C60P,OMAHA,NE 68178.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011
SN 0022-0736
J9 J ELECTROCARDIOL
JI J. Electrocardiol.
PY 1992
VL 24
SU S
BP 128
EP 129
PG 2
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA HG039
UT WOS:A1992HG03900030
ER

PT J
AU CAMPBELL, G
   NORMAN, JE
   LEVY, D
   BAILEY, JJ
AF CAMPBELL, G
   NORMAN, JE
   LEVY, D
   BAILEY, JJ
TI AGE AND HABITUS ADJUSTMENT OF ECG CRITERION IMPROVES DETECTION OF LVH AS
   SHOWN BY FUZZY ROC CURVES
SO JOURNAL OF ELECTROCARDIOLOGY
LA English
DT Article; Proceedings Paper
CT 16TH ANNUAL CONF OF THE INTERNATIONAL SOC FOR COMPUTERIZED
   ELECTROCARDIOLOGY
CY APR 21-26, 1991
CL SANTA BARBARA, CA
SP INT SOC COMP ELECTROCARDIOL, FUKUDA DENSHI AMER, HEWLETT PACKARD, MARQUETTE ELECTR, MORTARA INSTRUMENT, NIHON KOHDEN, PHYSIO CONTROL, QUINTON INSTRUMENT, SCHILLER, SIEMENS ELEMA
RP CAMPBELL, G (reprint author), NIH,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011
SN 0022-0736
J9 J ELECTROCARDIOL
JI J. Electrocardiol.
PY 1992
VL 24
SU S
BP 194
EP 194
PG 1
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA HG039
UT WOS:A1992HG03900042
PM 1532410
ER

PT J
AU MITSUYA, H
AF MITSUYA, H
TI DEVELOPMENT OF INHIBITORS OF REVERSE-TRANSCRIPTASE AND PROTEASE AS
   THERAPEUTICS AGAINST HIV-INFECTION
SO JOURNAL OF ENZYME INHIBITION
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS-RELATED COMPLEX; PHASE-I TRIAL;
   2',3'-DIDEOXYINOSINE DDI; REPLICATION INVITRO; ZIDOVUDINE AZT;
   HTLV-III/LAV; THERAPY; CELLS; 3'-AZIDO-3'-DEOXYTHYMIDINE
RP MITSUYA, H (reprint author), NCI, MED BRANCH, EXPTL RETROVIROL SECT, BETHESDA, MD 20892 USA.
NR 49
TC 7
Z9 7
U1 0
U2 0
PU HARWOOD ACAD PUBL GMBH, TAYLOR & FRANCIS GROUP
PI PHILADELPHIA
PA 325 CHESTNUT ST, 8TH FL, PHILADELPHIA, PA 19106 USA
SN 8755-5093
J9 J ENZYM INHIB
JI J. Enzym. Inhib.
PY 1992
VL 6
IS 1
BP 1
EP 8
DI 10.3109/14756369209041352
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JE668
UT WOS:A1992JE66800001
PM 1285300
ER

PT J
AU ABBOTTS, J
   WILSON, SH
AF ABBOTTS, J
   WILSON, SH
TI INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE AND FIDELITY OF INVITRO
   DNA-REPLICATION
SO JOURNAL OF ENZYME INHIBITION
LA English
DT Article
DE HIV-1; REVERSE TRANSCRIPTASE; ENZYME INHIBITION; DNA REPLICATION
   FIDELITY; FRAMESHIFT MUTATION; PROCESSIVITY
ID HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE-I KLENOW;
   3'-AZIDO-3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE; KINETIC MECHANISM;
   ESCHERICHIA-COLI; ZIDOVUDINE AZT; THERAPY; ALPHA; AIDS; PROCESSIVITY
AB Mechanisms of the effects of the dTTP analogues 3'-azido-3'-deoxythymidine 5'-triphosphate (AZTTP) and 3'-amino-3'-deoxythymidine 5'-triphosphate (NH2TTP) upon the HIV-1 reverse transcriptase (RT) are discussed. These compounds block the RT in vitro and do so by different kinetic mechanisms. Infidelity of replication is a hallmark of the HIV-1 RT, and replication errors by the enzyme on RNA and DNA templates are discussed. The enzyme's infidelity has ramifications for inhibition: On the one hand, the propensity to produce mutations enhances the ability of the virus to escape inhibitors whereas on the other hand, the infidelity of the reverse transcriptase may allow the development of imaginative inhibitor strategies.
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 52
TC 2
Z9 2
U1 1
U2 1
PU HARWOOD ACAD PUBL GMBH
PI READING
PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL
SN 8755-5093
J9 J ENZYM INHIB
JI J. Enzym. Inhib.
PY 1992
VL 6
IS 1
BP 35
EP 46
DI 10.3109/14756369209041354
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JE668
UT WOS:A1992JE66800003
PM 1285301
ER

PT J
AU YARCHOAN, R
   BRODER, S
AF YARCHOAN, R
   BRODER, S
TI CORRELATIONS BETWEEN THE INVITRO AND INVIVO ACTIVITY OF ANTI-HIV AGENTS
   - IMPLICATIONS FOR FUTURE DRUG DEVELOPMENT
SO JOURNAL OF ENZYME INHIBITION
LA English
DT Article
DE ANTI-HIV AGENTS; CD4; AZT; ZIDOVUDINE; DDC; DDI; REVERSE TRANSCRIPTASE;
   HIV-PROTEASE
ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS-RELATED COMPLEX; RECOMBINANT SOLUBLE
   CD4; PLACEBO-CONTROLLED TRIAL; HTLV-III; ZIDOVUDINE AZT; PHASE-I;
   REVERSE-TRANSCRIPTASE; REPLICATION INVITRO; DEXTRAN SULFATE
AB Some 10 years after the first recognition of acquired immunodeficiency syndrome (AIDS) as a new syndrome, we have identified a number of molecular targets to interrupt the replicative cycle of human immunodeficiency virus (HIV), the causative agent. A number of dideoxynucleosides have been identified as having anti-HIV activity in vitro, and several of these have been found to have clinical activity in patients. In contrast, while a number of agents have been found to block viral binding to the target cell in vitro, these agents have generally not shown clear-cut evidence of clinical activity. Agents which act at a variety of steps in the HIV replicative cycle are now under development, and it is likely that we will have an increased armamentarium to fight this disease in the near future.
RP YARCHOAN, R (reprint author), NCI, MED BRANCH, BLDG 10, RM 13N248, BETHESDA, MD 20892 USA.
NR 102
TC 2
Z9 2
U1 0
U2 0
PU HARWOOD ACAD PUBL GMBH, TAYLOR & FRANCIS GROUP
PI PHILADELPHIA
PA 325 CHESTNUT ST, 8TH FL, PHILADELPHIA, PA 19106 USA
SN 8755-5093
J9 J ENZYM INHIB
JI J. Enzym. Inhib.
PY 1992
VL 6
IS 1
BP 99
EP 111
DI 10.3109/14756369209041358
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JE668
UT WOS:A1992JE66800007
PM 1285306
ER

PT J
AU ILDSTAD, ST
   VACCHIO, MS
   MARKUS, PM
   HRONAKES, ML
   WREN, SM
   HODES, RJ
AF ILDSTAD, ST
   VACCHIO, MS
   MARKUS, PM
   HRONAKES, ML
   WREN, SM
   HODES, RJ
TI CROSS-SPECIES TRANSPLANTATION TOLERANCE - RAT BONE-MARROW DERIVED CELLS
   CAN CONTRIBUTE TO THE LIGAND FOR NEGATIVE SELECTION OF MOUSE T-CELL
   RECEPTOR-V-BETA IN CHIMERAS TOLERANT TO XENOGENEIC ANTIGENS (MOUSE + RAT
   -] MOUSE)
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID MAJOR HISTOCOMPATIBILITY COMPLEX; POLYMORPHIC SELF-ANTIGENS; CLONAL
   DELETION; ALLOTYPIC DETERMINANT; IMPARTS REACTIVITY; I-E; THYMUS; MICE;
   ANTIBODY; ANERGY
AB Mixed xenogeneic bone marrow reconstitution (mouse + rat --> mouse) results in stable mixed lymphopoietic chimerism (1-48% rat), long-term survival, and the induction of stable functional donor-specific transplantation tolerance to xenoantigens in vivo. To examine the role of negative selection of potentially xenoreactive T lymphocytes during tolerance induction across a species barrier, mixed xenogeneic chimeras (mouse + rat --> mouse) were prepared and analyzed using a mixture of mouse and rat bone marrow cells for relative T cell receptor (TCR(-V-beta-expression on mouse T cells. In mixed xenogeneic chimeras (B10 mouse + rat --> B10 mouse), T cell maturation proceeded normally in the presence of rat bone marrow-derived elements, and functional donor-specific tolerance to rat xenoantigens was present when assessed by mixed lymphocyte reactivity in vitro. V-beta-5, which is expressed at high (undeleted) levels in normal B10 mice, was consistently deleted in B10 recipients of Wistar Furth (WF), but not F344 rat bone marrow, whereas the coadministration of either F344 rat or WF rat bone marrow with B10 mouse bone marrow cells resulted in a significant decrease in expression of TCR-V-beta-11. Taken together, these data demonstrate for the first time that rat bone marrow-derived cells can contribute in a strain-specific manner to the ligand for negative selection of specific mouse TCR-V-beta during tolerance induction across a species barrier.
C1 NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892.
RP ILDSTAD, ST (reprint author), UNIV PITTSBURGH,DEPT SURG,DIV TRANSPLANTAT,BIOMED SCI TOWER W1556,PITTSBURGH,PA 15261, USA.
FU NIAID NIH HHS [R01 AI-30615]
NR 56
TC 26
Z9 26
U1 0
U2 0
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD JAN 1
PY 1992
VL 175
IS 1
BP 147
EP 155
DI 10.1084/jem.175.1.147
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA GY436
UT WOS:A1992GY43600018
PM 1530958
ER

PT J
AU RUBERTI, G
   SELLINS, KS
   HILL, CM
   GERMAIN, RN
   FATHMAN, CG
   LIVINGSTONE, A
AF RUBERTI, G
   SELLINS, KS
   HILL, CM
   GERMAIN, RN
   FATHMAN, CG
   LIVINGSTONE, A
TI PRESENTATION OF ANTIGEN BY MIXED ISOTYPE CLASS-II MOLECULES IN NORMAL
   H-2D MICE
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID T-CELL CLONES; MHC CLASS-II; MAJOR HISTOCOMPATIBILITY COMPLEX; E-ALPHA
   COMPLEX; SURFACE EXPRESSION; A-BETA; QUANTITATIVE DEFICIENCY; TRANSGENIC
   MICE; IA MOLECULE; CHAINS
AB A panel of DBA/2 T cell hybridomas specific for the sperm whale myoglobin epitope 110-121 was found to recognize antigen presented by the mixed isotype class II molecule E-alpha(d)A-beta(d). The response was blocked by monoclonal antibodies specific for E-alpha and A-beta(d) chains; in addition, the hybridomas responded to antigen presented by L cells expressing E-alpha(A)beta(d) molecules, and made no response with L cells expressing I-A(d) or I-E(d) molecules. Two more groups of hybridomas isolated from DBA/2 and B10.D2 mice immunized with myoglobin also recognized peptide 110-121 presented by E-alpha(d)A-beta(d). Thus, although it is expressed at biochemically undetectable levels on spleen cells, the E-alpha(d)A-beta(d) molecule is an important presenting element in normal H-2d mice making a conventional immune response to a protein antigen. These results suggest that high levels of class II expression are not a prerequisite for T cell activation.
C1 STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV IMMUNOL & RHEUMATOL,ROOM S021,STANFORD,CA 94305.
   IMMULOG PHARMACEUT CORP,PALO ALTO,CA 94304.
   NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
   BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND.
FU NIAID NIH HHS [AI-27989]
NR 33
TC 48
Z9 50
U1 0
U2 0
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD JAN 1
PY 1992
VL 175
IS 1
BP 157
EP 162
DI 10.1084/jem.175.1.157
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA GY436
UT WOS:A1992GY43600019
PM 1730914
ER

PT J
AU ESQUIVEL, F
   YEWDELL, J
   BENNINK, J
AF ESQUIVEL, F
   YEWDELL, J
   BENNINK, J
TI RMA/S CELLS PRESENT ENDOGENOUSLY SYNTHESIZED CYTOSOLIC PROTEINS TO
   CLASS-I RESTRICTED CYTOTOXIC LYMPHOCYTES-T
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID LYMPHOMA MUTANT; VIRAL PEPTIDES; VIRUS; ASSOCIATION; ANTIGENS; CHAINS;
   HEAVY
AB RMA/S is a mutant cell line with decreased cell surface expression of major histocompatibility complex class I molecules that has been reported to be deficient in presenting endogenously synthesized influenza virus nucleoprotein (NP) to cytotoxic T lymphocytes (CTL). In the present study we show that RMA/S cells can present vesicular stomatitis virus nucleocapsid protein, and, under some conditions, NP, to K(b)- and D(b)-restricted CTL, respectively. Antigen presentation results from processing of cytosolic pools of endogenously synthesized proteins, and not the binding to cell surface class I molecules of antigenic peptides present in the virus inoculum or released from infected cells. Antigen processing of RMA/S differs, however, from processing by wild-type cells in requiring greater amounts of antigen, longer times to assemble or transport class I-peptide complexes, and in being more sensitive to blocking by anti-CD8 antibody. Thus, the antigen processing deficit in RMA/S cells is of a partial rather than absolute nature.
RP ESQUIVEL, F (reprint author), NIAID,VIRAL DIS LAB,BLDG 4,ROOM 213,BETHESDA,MD 20892, USA.
RI yewdell, jyewdell@nih.gov/A-1702-2012
NR 16
TC 113
Z9 113
U1 0
U2 0
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD JAN 1
PY 1992
VL 175
IS 1
BP 163
EP 168
DI 10.1084/jem.175.1.163
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA GY436
UT WOS:A1992GY43600020
PM 1309852
ER

PT J
AU SU, H
   CALDWELL, HD
AF SU, H
   CALDWELL, HD
TI IMMUNOGENICITY OF A CHIMERIC PEPTIDE CORRESPONDING TO T-HELPER AND
   B-CELL EPITOPES OF THE CHLAMYDIA-TRACHOMATIS MAJOR OUTER-MEMBRANE
   PROTEIN
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID NUCLEOTIDE-SEQUENCE; GENE; DETERMINANTS; INFECTIONS; ANTIBODIES;
   RESOLUTION; IMMUNITY; COMMON; EYE
AB The immunogenicity of a chimeric T/B cell peptide corresponding to antigenically characterized epitopes of the Chlamydia trachomatis major outer membrane protein (MOMP) was studied in mice to further define its potential use in the development of a subunit vaccine in preventing blinding trachoma in humans. The chimeric peptide, designated A8-VDI, corresponds to a conserved MOMP T helper (Th) cell epitope(s) (A8, residues 106-130) and serovar A VDI (residues 66-80), which contains the serovar-specific neutralizing epitope 71VAGLEK76. Mice immunized with peptide A8-VDI produced high-titered polyclonal IgG antibodies which recognized the VAGLEK-neutralizing epitope. Peptide A8-VDI primed A/J mice to produce high-titered serum-neutralizing antibodies in response to a secondary immunization with intact chlamydial elementary bodies (EBs). Peptide A8-VDI, but not peptide VDI alone, was immunogenic in six different inbred strains of mice disparate at H-2, indicating that the Th cell epitope(s) contained in the A8 portion of the chimera was recognized in the context of multiple major histocompatibility complex (MHC) haplotypes. An unexpected finding of this work was that different inbred strains of mice immunized with the chimeric peptide produced antibodies of differing fine specificities to the VDI portion of the chimera. Some mouse strains produced anti-VDI antibodies that did not recognize the VAGLEK-neutralizing epitope. The ability of mice to respond to the VAGLEK-neutralizing site was not dependent on MHC haplotype since mouse strains of the same H-2 haplotype produced anti-VDI antibodies of differing fine specificity.
C1 NIAID,ROCKY MT LAB,INTRACELLULAR PARASITES LAB,HAMILTON,MT 59840.
NR 32
TC 58
Z9 59
U1 0
U2 0
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD JAN 1
PY 1992
VL 175
IS 1
BP 227
EP 235
DI 10.1084/jem.175.1.227
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA GY436
UT WOS:A1992GY43600028
PM 1370528
ER

PT J
AU GMELIGMEYLING, F
   DAWISHA, S
   STEINBERG, AD
AF GMELIGMEYLING, F
   DAWISHA, S
   STEINBERG, AD
TI ASSESSMENT OF INVIVO FREQUENCY OF MUTATED T-CELLS IN PATIENTS WITH
   SYSTEMIC LUPUS-ERYTHEMATOSUS
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Note
ID PERIPHERAL-BLOOD; MUTANT FREQUENCY; CLONING ASSAY; LYMPHOCYTES-T;
   MUTATIONS
AB The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation during the course of the disease. This represents the first demonstration of such a T cell abnormality in SLE; it supports the hypothesis that SLE T cells demonstrate increased in vivo division and/or survival.
C1 NIAMSD,ARTHRIT & RHEUMATISM BRANCH,CELLULAR IMMUNOL SECT,BLDG 10,ROOM 9N-218,BETHESDA,MD 20892.
NR 14
TC 52
Z9 52
U1 0
U2 0
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD JAN 1
PY 1992
VL 175
IS 1
BP 297
EP 300
DI 10.1084/jem.175.1.297
PG 4
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA GY436
UT WOS:A1992GY43600037
PM 1730923
ER

PT J
AU POMMERENKE, FA
   DIETRICH, A
AF POMMERENKE, FA
   DIETRICH, A
TI IMPROVING AND MAINTAINING PREVENTIVE SERVICES .1. APPLYING THE PATIENT
   MODEL
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Review
DE PREVENTIVE MEDICINE; PHYSICIAN-PATIENT RELATIONS; PHYSICIAN PRACTICE
   PATTERNS
ID HEALTH PROMOTION; CARE; IMPLEMENTATION
AB Research in the past two decades has made remarkable progress in determining the variables that affect preventive care within primary care practices. The level of preventive care that a patient receives is largely determined by factors within the medical office setting. Many of these factors can be modified by physicians to encourage preventive care. An overview of these factors, presented as the Patient Path Model, can provide a framework for systematic practice evaluation.  This model can be applied to almost any office setting to help identify opportunities to enhance and improve preventive care.
C1 NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892.
   DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT COMMUNITY & FAMILY MED,HANOVER,NH 03756.
NR 35
TC 48
Z9 48
U1 0
U2 0
PU APPLETON & LANGE
PI E NORWALK
PA 25 VAN ZANT ST, E NORWALK, CT 06855
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD JAN
PY 1992
VL 34
IS 1
BP 86
EP 91
PG 6
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA GZ447
UT WOS:A1992GZ44700019
PM 1728659
ER

PT J
AU POMMERENKE, FA
   DIETRICH, A
AF POMMERENKE, FA
   DIETRICH, A
TI IMPROVING AND MAINTAINING PREVENTIVE SERVICES, .2. PRACTICAL PRINCIPLES
   FOR PRIMARY CARE
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Review
DE PREVENTIVE HEALTH SERVICES; PRIMARY CARE
ID ADULT CANCER PREVENTION; HEALTH PROMOTION; FAMILY PRACTITIONERS;
   PRACTICE GUIDELINES; MEDICAL-PRACTICE; CONTROLLED TRIAL; PHYSICIANS;
   IMPLEMENTATION; DETERMINANTS
AB Recent research has recognized several themes that have been common to many successful projects for increasing cancer screening and other prevention activities. The most common of these themes have been condensed into "principles for implementation," intended to help physicians and other health care providers to improve the provision of preventive medical care within their practices.
C1 NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892.
   DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT COMMUNITY & FAMILY MED,HANOVER,NH 03756.
NR 47
TC 27
Z9 27
U1 2
U2 2
PU APPLETON & LANGE
PI E NORWALK
PA 25 VAN ZANT ST, E NORWALK, CT 06855
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD JAN
PY 1992
VL 34
IS 1
BP 92
EP 97
PG 6
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA GZ447
UT WOS:A1992GZ44700020
PM 1728660
ER

PT J
AU AMADORI, A
   BELARDELLI, F
   CAVALLO, F
   FERRARIS, PC
   DEROSSI, A
   DORIA, G
   FORNI, G
   FORNI, M
   GIAVAZZI, R
   JEMMA, C
   LOLLINI, PL
   LUSSO, P
   MEZZANZANICA, D
   NANNI, P
   PARMIANI, G
   RONCELLA, S
   SCALA, G
   SENSI, ML
AF AMADORI, A
   BELARDELLI, F
   CAVALLO, F
   FERRARIS, PC
   DEROSSI, A
   DORIA, G
   FORNI, G
   FORNI, M
   GIAVAZZI, R
   JEMMA, C
   LOLLINI, PL
   LUSSO, P
   MEZZANZANICA, D
   NANNI, P
   PARMIANI, G
   RONCELLA, S
   SCALA, G
   SENSI, ML
TI MIND THE MOUSE - A CONSENSUS VIEW ON THE USE OF IMMUNODEFICIENT MICE IN
   IMMUNOLOGY AND ONCOLOGY
SO JOURNAL OF IMMUNOLOGICAL RESEARCH
LA English
DT Editorial Material
ID NATURAL-KILLER-CELLS; HIV-INFECTED MICE; SCID-HU MOUSE; NUDE-MICE;
   VIRUS; METASTASIS; LEUKEMIA; TUMORS; GROWTH; TUMORIGENICITY
C1 CNR,CTR IMMUNOGENET & ISTOCOMPATIBIL,VIA SANTEN 19,I-10126 TURIN,ITALY.
   UNIV PADUA,IST ONCOL,I-35100 PADUA,ITALY.
   IST SUPER SANITA,I-00161 ROME,ITALY.
   UNIV TURIN,IST MICROBIOL,I-10124 TURIN,ITALY.
   IST SCI G GASLINI,GENOA,ITALY.
   ENEA,IMMUNOL LAB,ROME,ITALY.
   OSPED INFANTILE REGINA MARGHERITA,TURIN,ITALY.
   UNIV BOLOGNA,IST CANCEROL,I-40126 BOLOGNA,ITALY.
   NCI,BETHESDA,MD 20892.
   IST NAZL STUDIO & CURA TUMORI,MILAN,ITALY.
   IST SCI STUDIO & CURA TUMORI,SERV IMMUNOL CLIN,GENOA,ITALY.
   NAPLES UNIV,FAC MED 2,DIPARTIMENTO BIOCHIM & BIOTECNOL MED,I-80138 NAPLES,ITALY.
RI Lollini, Pier Luigi/A-7644-2008; Cavallo, Federica/C-5666-2011; De
   Rossi, Anita/L-3128-2015
OI Lollini, Pier Luigi/0000-0003-1702-4108; Cavallo,
   Federica/0000-0003-4571-1060; De Rossi, Anita/0000-0001-6435-7509
NR 48
TC 6
Z9 6
U1 0
U2 0
PU PENSIERO SCIENTIFICO EDITOR
PI ROME
PA VIA BRADANO 3/C, 00199 ROME, ITALY
SN 1120-3765
J9 J IMMUNOL RES
PD JAN-MAR
PY 1992
VL 4
IS 1
BP 1
EP 5
PG 5
WC Immunology
SC Immunology
GA HK498
UT WOS:A1992HK49800001
ER

PT J
AU HATHCOCK, KS
   LASZLO, G
   DICKLER, HB
   SHARROW, SO
   JOHNSON, P
   TROWBRIDGE, IS
   HODES, RJ
AF HATHCOCK, KS
   LASZLO, G
   DICKLER, HB
   SHARROW, SO
   JOHNSON, P
   TROWBRIDGE, IS
   HODES, RJ
TI EXPRESSION OF VARIABLE EXON A-SPECIFIC, B-SPECIFIC AND C-SPECIFIC CD45
   DETERMINANTS ON PERIPHERAL AND THYMIC T-CELL POPULATIONS
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID LEUKOCYTE-COMMON ANTIGEN; LYMPHOCYTE SPECIFIC HETEROGENEITY;
   MOLECULAR-WEIGHT ISOFORMS; MONOCLONAL-ANTIBODY; DIFFERENTIATION
   ANTIGENS; POLYPEPTIDE SEQUENCES; T200; IDENTIFICATION; RECEPTOR; SUBSETS
AB A mAb (I/24) has been generated that is specific for a determinant on mouse CD45 molecules. Reactivity of this mAb with a panel of CD45 transfected cell lines demonstrated that the determinant recognized is dependent upon expression of one or more CD45 variable exons and that exon C is sufficient for its expression. The exon C-specific epitope detected by I/24 is expressed at high density on essentially all B lymphocytes and at an intermediate density on the vast majority of CD8+ splenic T cells. Two distinct subpopulations of CD4+ splenic T cells were detected, a minor subpopulation that expresses this exon determinant at high density and a major subpopulation that expresses it at a much lower density. This first identification of a CD45RC-specific reagent allowed a comparison of the expression of exon A-, exon B-, and exon C-specific determinants on peripheral and thymic lymphoid populations. When splenic lymphocytes were analyzed for expression of CD45RA (reactive with mAb 14.8), CD45RB (reactive with mAb 23G2 or mAb 16.A), and CD45RC (reactive with mAb I/24) determinants, it was found that each of these CD45 determinants had a distinct pattern of expression on CD4+ and CD8+ T cells and B cells. CD45RB and RC epitopes were also detected at high density on a small proportion (0.7 to 4.1%) of thymocytes. Both CD45RB and RC epitopes were found predominantly on CD4-CD8- and CD4-CD8+ thymocytes but were also found on small numbers of CD4+CD8+ and CD4+CD8-cells. The population of thymocytes that expressed CD45RB and CD45RC determinants displayed a novel TCR CD3 phenotype characterized by a level of expression that was intermediate between that seen in the larger CD3 bright and CD3 dull populations of thymocytes.
C1 SALK INST BIOL STUDIES,DEPT CANC BIOL,SAN DIEGO,CA 92138.
RP HATHCOCK, KS (reprint author), NCI,EXPTL IMMUNOL BRANCH,BLDG 10,ROOM 4B17,BETHESDA,MD 20892, USA.
NR 42
TC 73
Z9 73
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 19
EP 28
PG 10
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200004
PM 1370168
ER

PT J
AU SMYTH, MJ
   NORIHISA, Y
   ORTALDO, JR
AF SMYTH, MJ
   NORIHISA, Y
   ORTALDO, JR
TI MULTIPLE CYTOLYTIC MECHANISMS DISPLAYED BY ACTIVATED HUMAN
   PERIPHERAL-BLOOD T-CELL SUBSETS
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID MEDIATED CYTO-TOXICITY; NATURAL-KILLER CELLS; LYMPHOCYTES-T; LYSIS;
   INDUCTION; GRANULES; ANTIBODIES; EXPRESSION; EXOCYTOSIS; CLONES
AB It has been proposed that CTL-mediated cytotoxicity may involve multiple lytic mechanisms. We have examined both the antibody-redirected cytolytic potential and the direct cytotoxicity of purified human peripheral blood high buoyant density CD4+ and CD8+ T cells activated with IL-2 and anti-CD3 mAb. TNF-sensitive and TNF-resistant targets and various metabolic inhibitors were used to compare the antibody-redirected cytotoxicity of T cell subsets and discern the role of potential lytic mediators. In a 4-h assay against several different nitrophenyl-modified targets, the heteroconjugated antibody (anti-CD3-anti-nitrophenyl) redirected cytolytic potential of 72-h activated CD4+ T cells was inhibited by the continuous presence of actinomycin D, cycloheximide, and EGTA, but not mitomycin C, cyclosporin A, or cholera toxin (CT). Conversely, only CT and EGTA inhibited the antibody-redirected cytolytic potential of activated CD8+ T cells. Despite both CD4+ and CD8+ T cell subsets expressing granzymes, pore-forming protein, TNF-beta, and TNF-alpha, these T cell subsets displayed distinct pathways of antibody-redirected lysis against TNF-sensitive and TNF-resistant targets, even in the presence of anti-TNF antibodies. In addition, these same effector T cell subsets were also directly cytotoxic (in the absence of heteroconjugated antibody) against TNF-sensitive targets in an 18-h assay. Indeed, this direct cytotoxicity was completely abrogated by anti-TNF-alpha-antibody and was sensitive to the metabolic inhibitors cyclosporin A, CT, cycloheximide, and actinomycin (D), all of which blocked CD4+/CD8+ T cell TNF-alpha production. Therefore, both CD4+ and CD8+ T cells were demonstrated to utilize antibody and lymphokine-mediated lytic mechanisms. CD4+ and CD8+ effector subsets were demonstrated to lyse the same TNF-sensitive target by these two different mechanisms. Although it cannot be excluded that the redirected lytic mechanisms of both CD4+ and CD8+ effectors share common elements, it is likely that other important events in this cytolytic process are fundamentally distinct between these subsets of T cells.
RP SMYTH, MJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,EXPTL IMMUNOL LAB,BIOL RESPONSE MODIFIERS PROGRAM,ROOM 31-93,FREDERICK,MD 21702, USA.
RI Smyth, Mark/H-8709-2014
OI Smyth, Mark/0000-0001-7098-7240
NR 29
TC 40
Z9 40
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 55
EP 62
PG 8
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200009
PM 1345790
ER

PT J
AU SPITZER, RE
   STITZEL, AE
   TSOKOS, GC
AF SPITZER, RE
   STITZEL, AE
   TSOKOS, GC
TI AUTOANTIBODY TO THE ALTERNATIVE PATHWAY C3/C5 CONVERTASE AND ITS
   ANTIIDIOTYPIC RESPONSE - A STUDY IN AFFINITY
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID SYSTEMIC LUPUS-ERYTHEMATOSUS; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS;
   SOMATIC MUTATION; NEPHRITIC FACTOR; C3 CONVERTASE; MATURATION;
   COMPLEMENT; ANTIBODIES; IGG; REPERTOIRE
AB In an effort to understand the development and control of autoantibody production, we studied the affinity of autoantibody to the alternative pathway C3/C5 convertase (C3 nephritic factor (C3NeF)) and its autoanti-idiotypic antibodies, Ab2-alpha and Ab2-beta. These were isolated and purified from newborns, normal adults, and patients with membranoproliferative glomerulonephritis. In all cases, both IgG and IgM C3NeF were available for study. The affinity of IgG and IgM C3NeF for their natural Ag (10(8) liters/mol) as well as for the internal image of that Ag displayed on Ab2-beta was high (10(10) liters/mol). Furthermore, the affinity of IgG C3NeF was nearly 100-fold higher in patients than in newborns, whereas there were no significant changes with IgM C3NeF. By contrast, there were no differences in the affinity of IgG Ab2-alpha (which does not display any likeness to the native Ag) from normal adults and patients to any C3NeF isolate. There was, however, a progressive increase in affinity between both Ab2-alpha preparations and IgG C3NeF from newborns, adult normal subjects, and patients, implying an alteration in C3NeF to account for the changes in affinity. These data suggest that Ag-driven affinity maturation occurs with autoantibody but may not occur within the idiotypic network. These data also indicate that as autoantibody affinity matures, it appears to modify its idiotype, perhaps in an effort towards autoregulation.
C1 NIH,BETHESDA,MD 20892.
   UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20892.
RP SPITZER, RE (reprint author), SUNY HLTH SCI CTR,DEPT PEDIAT,750 E ADAMS ST,SYRACUSE,NY 13210, USA.
NR 30
TC 11
Z9 11
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 137
EP 141
PG 5
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200021
PM 1727863
ER

PT J
AU GAZZINELLI, RT
   MAKINO, M
   CHATTOPADHYAY, SK
   SNAPPER, CM
   SHER, A
   HUGIN, AW
   MORSE, HC
AF GAZZINELLI, RT
   MAKINO, M
   CHATTOPADHYAY, SK
   SNAPPER, CM
   SHER, A
   HUGIN, AW
   MORSE, HC
TI CD4+ SUBSET REGULATION IN VIRAL-INFECTION - PREFERENTIAL ACTIVATION OF
   TH2 CELLS DURING PROGRESSION OF RETROVIRUS-INDUCED IMMUNODEFICIENCY IN
   MICE
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID STIMULATORY FACTOR-I; STAPHYLOCOCCAL ENTEROTOXIN-B; HELPER T-CELLS;
   INTERFERON-GAMMA; PROLIFERATIVE RESPONSE; MONOCLONAL-ANTIBODIES;
   CYTOKINE PRODUCTION; GENE-EXPRESSION; IMMUNE-RESPONSE; IGE RESPONSES
AB Progressive lymphoproliferation and increasingly severe immunodeficiency are prominent features of a syndrome, designated mouse AIDS, which develops in susceptible strains of mice infected with the mixture of murine leukemia viruses, termed LP-BM5. Development of splenomegaly and lymphadenopathy, caused primarily by increases in B cell immunoblasts, requires the presence of CD4+ T cells and is assumed to be mediated by lymphokines produced by these cells inasmuch as progression of disease is markedly inhibited by treatment of infected mice with cyclosporin A. Studies of spleen cells from infected mice revealed spontaneous production of cytokines (IFN-gamma, IL-2, IL-4, IL-5, and IL-10) characteristic of Th0 (or a mixture of Th1 and Th2) T helper cells at 1 wk after infection. At later times, IFN-gamma and IL-2, characteristic products of Th1 helper clones, were expressed poorly, either spontaneously or after stimulation of cells with Con A. In contrast, IL-4, IL-5, IL-6, and IL-10, cytokines typically synthesized by Th2 cells, were produced in response to Con A or spontaneously through 18 wk post-infection. Increased serum IgE levels and enhanced IL-10 mRNA expression were consistent with expression of Th2 cytokines at biologically significant levels in vivo. Selective depletion of T cell subsets before stimulation with Con A showed that CD4+ T cells were the primary source of IL-2, IL-4, IL-10, and, to a lesser extent, IFN-gamma in spleens and lymph nodes of normal or infected mice. These results suggest that persistent activation of CD4+ T cells with the lymphokine profile of Th2 helper clones is responsible for chronic B cell stimulation, down-regulation of Th1 cytokines, and impaired CD8+ T cell function in mouse AIDS. This provides the first demonstration that, like many parasitic infections, viruses encoding potent antigenic stimuli can markedly affect the balance of Th subset expression.
C1 NIAID,IMMUNOPATHOL LAB,BLDG 7,ROOM 304,BETHESDA,MD 20892.
   NIAID,PARASIT DIS LAB,BETHESDA,MD 20892.
   UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814.
OI Morse, Herbert/0000-0002-9331-3705
FU NIAID NIH HHS [N0-AI-72622]
NR 72
TC 230
Z9 231
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 182
EP 188
PG 7
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200028
PM 1345785
ER

PT J
AU SAYERS, TJ
   WILTROUT, TA
   SOWDER, R
   MUNGER, WL
   SMYTH, MJ
   HENDERSON, LE
AF SAYERS, TJ
   WILTROUT, TA
   SOWDER, R
   MUNGER, WL
   SMYTH, MJ
   HENDERSON, LE
TI PURIFICATION OF A FACTOR FROM THE GRANULES OF A RAT NATURAL-KILLER-CELL
   LINE (RNK) THAT REDUCES TUMOR-CELL GROWTH AND CHANGES TUMOR MORPHOLOGY -
   MOLECULAR IDENTITY WITH A GRANULE SERINE PROTEASE (RNKP-1)
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID TOXIC LYMPHOCYTE-T; PORE-FORMING PROTEIN; MEDIATED CYTO-TOXICITY;
   CYTOPLASMIC GRANULES; FUNCTIONAL-CHARACTERIZATION; CYTOLYTIC ACTIVITY;
   GENE-EXPRESSION; INDUCTION; ESTERASE; ADHESION
AB We have purified a protein from the granules of the rat NK leukemia cell line (RNK) that is cytostatic to a variety of tumor cells. This protein shows no species specificity because certain tumor cell lines of mouse, rat, and human origin were equally sensitive to its growth inhibitory effects. Treatment of sensitive cells resulted in a rounding of the cells followed by homotypic aggregation into large aggregates. The granule protein was distinct from cytolysin, N(alpha)-Cbz-Lys-thiobenzylester-esterase, or leukolexin. It had a molecular mass of 29 to 31 kDa, bound strongly to heparin, was inactivated by heating at 70-degrees-C for 5 min or reduction, but was stable to trypsin treatment. By using molecular sieve chromatography, heparin agarose chromatography, and reverse phase HPLC, this protein was purified to homogeneity. The first 33 amino acids of the N-terminal amino acid sequence showed complete identity to the sequence predicted from a rat serine protease gene recently cloned and designated RNKP-1. Therefore we have purified a novel serine protease and demonstrated that it has effects on the growth and morphology of certain tumor cells. Other serine proteases that were structurally related and have substantial homology with RNKP-1 at the amino acid level showed neither growth inhibitory properties nor affected the morphology of the tumor target cells we used.
C1 PRI DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702.
   PRI DYNCORP,AIDS VACCINE DEV PROGRAM,FREDERICK,MD 21702.
RP SAYERS, TJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,EXPTL IMMUNOL LAB,BIOL RESPONSE MODIFIERS PROGRAM,BLDG 560,FREDERICK,MD 21702, USA.
RI Sayers, Thomas/G-4859-2015; Smyth, Mark/H-8709-2014
OI Smyth, Mark/0000-0001-7098-7240
FU NCI NIH HHS [N01-CO-74102]
NR 56
TC 46
Z9 47
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 292
EP 300
PG 9
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200044
PM 1727874
ER

PT J
AU KABAT, EA
AF KABAT, EA
TI HEIDELBERGER,MICHAEL - APRIL 29, 1888 JUNE 25, 1991 - OBITUARY
SO JOURNAL OF IMMUNOLOGY
LA English
DT Item About an Individual
C1 COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032.
   COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032.
   NIH,OFF DIRECTOR,BETHESDA,MD 20892.
RP KABAT, EA (reprint author), COLUMBIA UNIV COLL PHYS & SURG,DEPT MICROBIOL,NEW YORK,NY 10032, USA.
NR 15
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JAN 1
PY 1992
VL 148
IS 1
BP 301
EP 307
PG 7
WC Immunology
SC Immunology
GA GX162
UT WOS:A1992GX16200045
PM 1727875
ER

PT J
AU JICHA, DL
   YANNELLI, JR
   CUSTER, M
   COLANDREA, J
   TAUBENBERGER, J
   MULE, JJ
   ROSENBERG, SA
AF JICHA, DL
   YANNELLI, JR
   CUSTER, M
   COLANDREA, J
   TAUBENBERGER, J
   MULE, JJ
   ROSENBERG, SA
TI THE PERSISTENCE OF HUMAN PERIPHERAL LYMPHOCYTES, TUMOR INFILTRATING
   LYMPHOCYTES, AND COLON ADENOCARCINOMAS IN IMMUNODEFICIENT MICE
SO JOURNAL OF IMMUNOTHERAPY
LA English
DT Article
DE IMMUNODEFICIENT MICE; PERIPHERAL BLOOD MONONUCLEAR CELLS; TUMOR
   INFILTRATING LYMPHOCYTES; HUMAN COLON ADENOCARCINOMAS
ID SCID-HU MOUSE; NATURAL-KILLER CELLS; IMMUNE-DEFICIENCY; STEM-CELLS;
   INTERLEUKIN-2; IMMUNOTHERAPY; INFECTION; MODEL
AB The reconstitution of severely immunodeficient mice with human peripheral blood mononuclear cells (PBMCs) may represent a unique model system to evaluate human antitumor responses.  To evaluate this possibility, we studied human PBMC reconstitution, human tumor infiltrating lymphocyte (TIL) persistence, and human colon adenocarcinoma propagation in beige/nude/xid (BNX) and in severe combined immunodeficient (SCID) mice.  To evaluate human PBMC reconstitution, 75 mice received 1 x 10(7)-1 x 10(9) human PBMCs i.p. or i.v. and were studied at intervals ranging from 1 to 8 weeks by fluorescence-activated cell sorting (FACS) analysis and by measurement of circulating human immunoglobulin levels.  By FACS analyses, only one of 75 mice had evidence of human PBMC persistence at 2 weeks in the spleen.  Moreover, liver and peritoneum showed evidence of human cells in only 13 of 56 and 16 of 55 mice, respectively.  In these mice, human cells comprised 1-77% of total cells recovered.  Human immunoglobulin levels in mouse serum ranged from 0 to 34,000-mu-g/ml and correlated only weakly with evidence of human PBMC reconstitution in peripheral organs, but were generally higher in SCID mice than in BNX mice.  Human TIL persistence was evaluated in BNX and SCID mice that were given 3 x 10(7) TILs i.v. (in divided doses) or 1 x 10(8) i.p. TILs along with interleukin-2 administration.  At 1, 2, 7, and 14 days following TIL delivery, evidence of human TIL persistence in liver, lung, peritoneum, and spleen was evaluated by FACS analysis.  Fresh organ suspensions did not contain human TILs.  In mice given cyclophosphamide followed by human TILs i.p., the TILs were demonstrated at 7 days in the SCID peritoneum (leu 4 = 4%) and at 2 days in the SCID spleen (leu 4 = 2%).  In BNX mice, 12 of 14 fresh human colon adenocarcinomas were propagated successfully at subcutaneous sites with latency periods ranging from 1 to 13 weeks.  Enzymatic disaggregation of tumors > 1 cm following one passage yielded 6.5-47 x 10(6) cells with viabilities ranging from 13 to 85%.  We conclude that limitations and variability exist in the use of BNX and SCID mice for human PBMC reconstitution, TIL persistence, and propagation of human colon adenocarcinomas.
C1 NCI,SURG BRANCH,BETHESDA,MD 20892.
   NCI,PATHOL LAB,BETHESDA,MD 20892.
NR 23
TC 21
Z9 21
U1 0
U2 2
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 1053-8550
J9 J IMMUNOTHER
JI J. Immunother.
PD JAN
PY 1992
VL 11
IS 1
BP 19
EP 29
DI 10.1097/00002371-199201000-00003
PG 11
WC Oncology; Immunology; Medicine, Research & Experimental
SC Oncology; Immunology; Research & Experimental Medicine
GA GW052
UT WOS:A1992GW05200003
PM 1734945
ER

PT J
AU BALIS, FM
   PIZZO, PA
   BUTLER, KM
   HAWKINS, ME
   BROUWERS, P
   HUSSON, RN
   JACOBSEN, F
   BLANEY, SM
   GRESS, J
   JAROSINSKI, P
   POPLACK, DG
AF BALIS, FM
   PIZZO, PA
   BUTLER, KM
   HAWKINS, ME
   BROUWERS, P
   HUSSON, RN
   JACOBSEN, F
   BLANEY, SM
   GRESS, J
   JAROSINSKI, P
   POPLACK, DG
TI CLINICAL-PHARMACOLOGY OF 2',3'-DIDEOXYINOSINE IN HUMAN IMMUNODEFICIENCY
   VIRUS-INFECTED CHILDREN
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID AIDS-RELATED COMPLEX; PHASE-I TRIAL; CONTINUOUS-INFUSION;
   PHARMACOKINETICS; INVITRO; 2',3'-DIDEOXYNUCLEOSIDES; INFECTIVITY;
   INHIBITION; HIV; DDI
AB The pharmacokinetics of intravenous and oral 2',3'-dideoxyinosine (ddI) and the relationships between pharmacokinetic parameters and measures of response were studied in 48 human immunodeficiency virus-infected children.  Disappearance of ddI from plasma after the intravenous dose was rapid and biexponential, with half-lives of 12 min and 1.0 h and a total clearance of 510 +/- 180 ml/min/m2.  After oral administration, ddI absorption was limited and variable (mean bioavailability, 19% +/- 17%).  A plasma ddI concentration-response relationship was observed for both decline in viral p24 antigen levels and improvement in intelligence quotient score.  A limited sampling model was developed that accurately predicts the area under the ddI plasma concentration-time curve from one to three plasma samples.  Although this pharmacokinetic study was done in children, the results also have relevance to adults and suggest that individualization of dose and schedule through therapeutic drug monitoring may be necessary to achieve optimal response.
C1 NIH,CTR CLIN,DEPT PHARM,BETHESDA,MD 20892.
RP BALIS, FM (reprint author), NCI,PEDIAT BRANCH,BLDG 10,RM 13N240,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 19
TC 86
Z9 86
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD JAN
PY 1992
VL 165
IS 1
BP 99
EP 104
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA GW582
UT WOS:A1992GW58200013
PM 1727902
ER

PT J
AU CLEMENS, JD
   WARD, RL
   RAO, MR
   SACK, DA
   KNOWLTON, DR
   VANLOON, FPL
   HUDA, S
   MCNEAL, M
   AHMED, F
   SCHIFF, G
AF CLEMENS, JD
   WARD, RL
   RAO, MR
   SACK, DA
   KNOWLTON, DR
   VANLOON, FPL
   HUDA, S
   MCNEAL, M
   AHMED, F
   SCHIFF, G
TI SEROEPIDEMIOLOGIC EVALUATION OF ANTIBODIES TO ROTAVIRUS AS CORRELATES OF
   THE RISK OF CLINICALLY SIGNIFICANT ROTAVIRUS DIARRHEA IN RURAL
   BANGLADESH
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID PROTECTION; INFECTION; DISEASES
AB A case-control study was conducted among children and adult women in rural Bangladesh to evaluate whether serologic immunity to rotavirus was associated with a lower risk of rotavirus diarrhea of sufficient severity to cause patients to seek medical care.  Acute-phase sera from 219 cases of rotavirus diarrhea, detected among patients treated in three diarrheal treatment centers, were compared with sera from 477 contemporaneously selected community controls.  Overall, serum IgG antirotavirus antibody titers were nearly one-fourth as high in cases as in controls (107 vs. 417 units/ml; P < .001).  Among persons aged greater-than-or-equal-to 8 months, in whom titers of maternal antirotavirus antibodies should have been negligible, even the lowest range of detectable titers (100-200 units/ml) was associated with a substantial (75%, P < .05) reduction of the risk of rotavirus diarrhea.  We conclude that titers of serum IgG antirotavirus antibodies induced by earlier infection were inversely related to the risk of clinically significant rotavirus diarrhea.
C1 JOHNS HOPKINS UNIV,SCH MED,JAMES N GAMBLE INST MED RES,BALTIMORE,MD 21205.
   INT CTR DIARRHOEL DIS RES,BANGLADESH,BANGLADESH.
RP CLEMENS, JD (reprint author), NICHHD,DIV EPIDEMIOL STAT & PREVENT RES,RM 640,EXECUT PLAZA N,BETHESDA,MD 20892, USA.
NR 15
TC 40
Z9 46
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD JAN
PY 1992
VL 165
IS 1
BP 161
EP 165
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA GW582
UT WOS:A1992GW58200025
PM 1309372
ER

PT J
AU WILBUR, WJ
   SIROTKIN, K
AF WILBUR, WJ
   SIROTKIN, K
TI THE AUTOMATIC IDENTIFICATION OF STOP WORDS
SO JOURNAL OF INFORMATION SCIENCE
LA English
DT Article
ID INFORMATION-RETRIEVAL
AB A stop word may be identified as a word that has the same likelihood of occurring in those documents not relevant to a query as in those documents relevant to the query. In this paper we show how the concept of relevance may be replaced by the condition of being highly rated by a similarity measure. Thus it becomes possible to identify the stop words in a collection by automated statistical testing. We describe the nature of the statistical test as it is realized with a vector retrieval methodology based on the cosine coefficient of document-document similarity. As an example, this technique is then applied to a large MEDLINE(R) subset in the area of biotechnology. The initial processing of this database involves a 310 word stop list of common non-content terms. Our technique is then applied and 75% of the remaining terms are identified as stop words. We compare retrieval with and without the removal of these stop words and find that of the top twenty documents retrieved in response to a random query document, seventeen of these are the same on the average for the two methods. We also examine the differences and conclude that where the user prefers one method over the other, the new method with the reduced term set is favored about three times out of four.
RP NIH, NATL LIB MED, NATL CTR BIOTECH INFORMAT, BLDG 38A, 8600 ROCKVILLE PIKE, BETHESDA, MD 20894 USA.
NR 15
TC 58
Z9 59
U1 2
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0165-5515
EI 1741-6485
J9 J INF SCI
JI J. Inf. Sci.
PY 1992
VL 18
IS 1
BP 45
EP 55
DI 10.1177/016555159201800106
PG 11
WC Computer Science, Information Systems; Information Science & Library
   Science
SC Computer Science; Information Science & Library Science
GA HF751
UT WOS:A1992HF75100006
ER

PT J
AU MUENZER, J
   NEUFELD, EF
   CONSTANTOPOULOS, G
   CARUSO, RC
   KAISERKUPFER, MI
   PIKUS, A
   DANOFF, J
   BERRY, RR
   MCDONALD, HD
   THOMPSON, JN
   RODEN, L
   ZASLOFF, MA
AF MUENZER, J
   NEUFELD, EF
   CONSTANTOPOULOS, G
   CARUSO, RC
   KAISERKUPFER, MI
   PIKUS, A
   DANOFF, J
   BERRY, RR
   MCDONALD, HD
   THOMPSON, JN
   RODEN, L
   ZASLOFF, MA
TI ATTEMPTED ENZYME REPLACEMENT USING HUMAN AMNION MEMBRANE IMPLANTATIONS
   IN MUCOPOLYSACCHARIDOSES
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
ID BONE-MARROW TRANSPLANTATION; LYSOSOMAL STORAGE DISEASES; HUNTER
   SYNDROME; FIBROBLAST TRANSPLANTATION; EPITHELIAL-CELLS; CDNA CLONE;
   PLASMA; THERAPY; TRIAL; GLYCOSAMINOGLYCANS
AB Amnion membrane implantation has been proposed as an approach to enzyme replacement in mucopolysaccharidoses. Human amnion membranes have been subcutaneously implanted in the abdominal wall in 19 patients with mucopolysaccharidoses (MPS I, II and III). A protocol was developed for the objective evaluation of experimental treatments of these patients. Systematic evaluation of the clinical status before and 6 months after amnion membrane implantation reveals no change in function except improvement in joint mobility. The sum of all joint movements showed improvement from baseline values to 6 months after implantation by ANOVA followed by post-hoc analysis (p < 0.056). The only specific joint movements to significantly improve after 6 months were shoulder extension (p < 0.01) and hip internal rotation (p < 0.05). Serial measurements of the deficient lysosomal enzyme activity in serum and white blood cells did not increase in any patient after amnion membrane implantation. Urinary glycosaminoglycan excretion decreased transiently in 2 of 10 patients after implantation, but a second amnion membrane implantation did not result in any change. Biopsy of the implantation site in 10 patients 6 months after amnion membrane implantation revealed a foreign-body reaction with giant cell formation and fibrosis and no recognizable amnion membrane tissue. We conclude that human amnion membrane implantation is not an effective therapy in mucopolysaccharidoses.
C1 NIDDKD,GENET & BIOCHEM BRANCH,BETHESDA,MD 20892.
   NINCDS,DEV & METAB NEUROL BRANCH,BETHESDA,MD 20892.
   NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892.
   NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT AUDIOL,BETHESDA,MD 20892.
   NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT REHABIL MED,BETHESDA,MD 20892.
   NCI,DIV CANC TREATMENT,SURG BRANCH,BETHESDA,MD 20892.
   UNIV ALABAMA,MED GENET LAB,BIRMINGHAM,AL 35294.
RP MUENZER, J (reprint author), NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892, USA.
NR 48
TC 12
Z9 12
U1 0
U2 1
PU KLUWER ACADEMIC PUBL
PI DORDRECHT
PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PY 1992
VL 15
IS 1
BP 25
EP 37
DI 10.1007/BF01800340
PG 13
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA HK138
UT WOS:A1992HK13800003
PM 1533888
ER

PT J
AU BLOM, HJ
   DAVIDSON, AJ
   FINKELSTEIN, JD
   LUDER, AS
   BERNARDINI, I
   MARTIN, JJ
   TANGERMAN, A
   TRIJBELS, JMF
   MUDD, SH
   GOODMAN, SI
   GAHL, WA
AF BLOM, HJ
   DAVIDSON, AJ
   FINKELSTEIN, JD
   LUDER, AS
   BERNARDINI, I
   MARTIN, JJ
   TANGERMAN, A
   TRIJBELS, JMF
   MUDD, SH
   GOODMAN, SI
   GAHL, WA
TI PERSISTENT HYPERMETHIONINAEMIA WITH DOMINANT INHERITANCE
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
ID METHIONINE ADENOSYLTRANSFERASE DEFICIENCY; TRANSAMINATION PATHWAY;
   VASCULAR-DISEASE; METABOLISM; MAMMALS; HOMOCYSTINEMIA; HOMOCYSTEINE;
   SYNTHETASE; ADULT; FORMS
AB A clinically benign form of persistent hypermethioninaemia with probable dominant inheritance was demonstrated in three generations of one family. Plasma methionine concentrations were between 87 and 475-mu-mol/L (normal mean 26-mu-mol/L; range 10-40-mu-mol/L); urinary methionine and homocystine concentrations were normal. Plasma homocystine, cystathionine, cystine and tyrosine were virtually normal. The concentrations in serum and urine of metabolites formed by the methionine transamination pathway were normal or moderately elevated. Methionine loading of two affected family members revealed a diminished ability to catabolize methionine, but the activities of methionine adenosyltransferase and cystathionine beta-synthase were not decreased in fibroblasts from four affected family members. Fibroblast methylenetetrahydrofolate reductase activity and its inhibition by S-adenosylmethionine were also normal, indicating normal regulation of N5-methyltetrahydrofolate-dependent homocysteine remethylation. Serum folate concentrations were not increased.
   The findings in this family differ from those previously described for known defects of methionine degradation. Since the hepatic and fibroblast isoenzymes of methionine adenosyltransferase differ in their genetic control, this family's biochemical findings appear consistent with a mutation in the structural gene for the hepatic methionine adenosyltransferase isoenzyme.
C1 NICHHD,HUMAN GENET BRANCH,HUMAN BIOCHEM GENET SECT,BETHESDA,MD 20892.
   UNIV COLORADO,HLTH SCI CTR,DEPT PEDIAT,DENVER,CO 80262.
   DEPT VET AFFAIRS MED CTR,WASHINGTON,DC 20422.
   UNIV HOSP NIJMEGEN,DEPT MED,DIV GASTROINTESTINAL & LIVER DIS,NIJMEGEN,NETHERLANDS.
   NIMH,BETHESDA,MD 20892.
RP BLOM, HJ (reprint author), UNIV HOSP NIJMEGEN,DEPT PEDIAT,POB 9101,6500 HB NIJMEGEN,NETHERLANDS.
FU NCRR NIH HHS [RR-69]; NIDDK NIH HHS [DK-13048]; PHS HHS [MCJ000252]
NR 30
TC 13
Z9 13
U1 0
U2 1
PU KLUWER ACADEMIC PUBL
PI DORDRECHT
PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PY 1992
VL 15
IS 2
BP 188
EP 197
DI 10.1007/BF01799629
PG 10
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA HV255
UT WOS:A1992HV25500004
PM 1527987
ER

PT J
AU FISHER, GJ
   TAVAKKOL, A
   GRIFFITHS, CEM
   ELDER, JT
   ZHANG, QY
   FINKEL, L
   DANIELPOUR, D
   GLICK, AB
   HIGLEY, H
   ELLINGSWORTH, L
   VOORHEES, JJ
AF FISHER, GJ
   TAVAKKOL, A
   GRIFFITHS, CEM
   ELDER, JT
   ZHANG, QY
   FINKEL, L
   DANIELPOUR, D
   GLICK, AB
   HIGLEY, H
   ELLINGSWORTH, L
   VOORHEES, JJ
TI DIFFERENTIAL MODULATION OF TRANSFORMING GROWTH FACTOR-BETA-1 EXPRESSION
   AND MUCIN DEPOSITION BY RETINOIC ACID AND SODIUM LAURYL SULFATE IN HUMAN
   SKIN
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Article
ID COMPLEMENTARY-DNA SEQUENCE; FACTOR-BETA; CELLULAR RECEPTOR; PHOTOAGED
   SKIN; CELLS; LOCALIZATION; ANTIBODIES
AB Immunohistochemical staining of skin sections with two polyclonal antibodies (anti-CC 1-30 and anti-LC 1-30), specific for transforming growth factor-beta-1, revealed increased extracellular and decreased intracellular expression of transforming growth factor-beta-1 in retinoic acid-treated, compared to vehicle-treated, skin. Transforming growth factor-beta-1 staining, with both antibodies, was most marked in the upper layers of the epidermis, although dermal staining was also evident. The modulation of transforming growth factor-beta-1 expression by retinoic acid occurred in the absence of any change in its mRNA level. Transforming growth factor-beta-1 protein, as detected by rabbit polyclonal antibody (anti-LC 50-75) and mRNA, were only minimally detected in either retinoic acid- or vehicle-treated skin. Similar changes in TGF-beta-1 and TGF-beta-2 immunoreactivity and mRNA levels, as observed in retinoic acid-treated skin, were observed in skin following topical application of the irritant sodium lauryl sulfate, indicating that the alterations induced by retinoic acid were not specific. In contrast, mucin deposition, which is induced by transforming growth factor-beta, was elevated in retinoic acid-treated but not sodium lauryl sulfate-treated skin. Cultured adult human keratinocytes also expressed predominantly transforming growth factor-beta-1 protein, as measured by ELISA, and mRNA. Treatment of keratinocytes with retinoic acid resulted in a 50% induction of transforming growth factor-beta-1 protein, without any detectable change in transforming growth factor-beta-2. These data demonstrate disassociation of modulation of transforming growth factor-beta-1 expression and mucin deposition by retinoic acid and sodium lauryl sulfate in human skin in vivo. Whereas alterations in transforming growth factor-beta-1 expression were observed in both retinoic acid - and sodium lauryl sulfate-treated skin, accumulation of mucin was specific to retinoic acid-treated skin.
C1 NCI, CHEMOPREVENT LAB, BETHESDA, MD 20892 USA.
   CELTRIX LABS, PALO ALTO, CA USA.
RP FISHER, GJ (reprint author), UNIV MICHIGAN, DEPT DERMATOL, 1301 E CATHERINE, KRESGE I, ANN ARBOR, MI 48109 USA.
RI Griffiths, Christopher/P-5448-2014
OI Griffiths, Christopher/0000-0001-5371-4427
NR 37
TC 51
Z9 51
U1 0
U2 1
PU BLACKWELL SCIENCE INC
PI MALDEN
PA 350 MAIN ST, MALDEN, MA 02148
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD JAN
PY 1992
VL 98
IS 1
BP 102
EP 108
DI 10.1111/1523-1747.ep12495896
PG 7
WC Dermatology
SC Dermatology
GA GW090
UT WOS:A1992GW09000018
PM 1728634
ER

PT J
AU NIMS, RW
   GROVE, JF
   HO, MYK
   STREETER, AJ
   KEEFER, LK
AF NIMS, RW
   GROVE, JF
   HO, MYK
   STREETER, AJ
   KEEFER, LK
TI ION-PAIRING SYSTEMS FOR SEPARATION OF N-NITROSODIMETHYLAMINE AND ITS
   METABOLITES IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID RAT-LIVER MICROSOMES; DENITROSATION; DEMETHYLATION; NITROSAMINES;
   CYTOCHROME-P-450
AB Separation of N-nitrosodimethylamine and certain of its metabolites on a C18 column is made possible by the inclusion of ion-pairing reagent into a mobile phase consisting of 7 mM ammonium phosphate, pH 3.0.  The use of alkanesulfonates (5 mM) of varying alkyl chain length to afford retention of the putative metabolites, monomethylamine and dimethylamine, is discussed.  The incorporation of sodium 1-heptane- or 1-octanesulfonate into the mobile phase appears to provide optimal separation under conditions in which the parent nitrosamine is present in the samples at relatively low or high concentrations, respectively.
RP NIMS, RW (reprint author), NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,CHEM SECT,FREDERICK,MD 21702, USA.
RI Keefer, Larry/N-3247-2014
OI Keefer, Larry/0000-0001-7489-9555
NR 17
TC 5
Z9 5
U1 0
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 2
BP 195
EP 206
DI 10.1080/10826079208017164
PG 12
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA HC792
UT WOS:A1992HC79200001
ER

PT J
AU JANINI, GM
   ISSAQ, HJ
AF JANINI, GM
   ISSAQ, HJ
TI MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY - BASIC CONSIDERATIONS
   AND CURRENT TRENDS
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article; Proceedings Paper
CT 2ND ANNUAL FREDERICK CONF ON CAPILLARY ELECTROPHORESIS
CY OCT 15-16, 1991
CL FREDERICK, MD
SP NATL CANC INST, FREDERICK CANC RES & DEV CTR
ID OPEN-TUBULAR CAPILLARIES; AMINO-ACID ENANTIOMERS; WATER-SOLUBLE
   VITAMINS; ZONE ELECTROPHORESIS; MOBILE PHASE; ELECTROCHEMICAL
   PARAMETERS; 3 MODES; SEPARATION; PERFORMANCE; OPTIMIZATION
AB A brief review of micellar electrokinetic capillary chromatography is presented.  Basic theory of MECC, a discussion of types of micelles in MECC and its application to different classes of compounds is presented.  Selected examples, which illustrate the advantages of MECC over capillary zone electrophoresis are also given.
RP JANINI, GM (reprint author), NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,DYN CORP,POB B,FREDERICK,MD 21702, USA.
NR 122
TC 58
Z9 59
U1 1
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 6-7
BP 927
EP 960
DI 10.1080/10826079208018846
PG 34
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA HP807
UT WOS:A1992HP80700002
ER

PT J
AU ISSAQ, HJ
   JANINI, GM
   ATAMNA, IZ
   MUSCHIK, GM
   LUKSZO, J
AF ISSAQ, HJ
   JANINI, GM
   ATAMNA, IZ
   MUSCHIK, GM
   LUKSZO, J
TI CAPILLARY ELECTROPHORESIS SEPARATION OF SMALL PEPTIDES - EFFECT OF PH,
   BUFFER ADDITIVES, AND TEMPERATURE
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article; Proceedings Paper
CT 2ND ANNUAL FREDERICK CONF ON CAPILLARY ELECTROPHORESIS
CY OCT 15-16, 1991
CL FREDERICK, MD
SP NATL CANC INST, FREDERICK CANC RES & DEV CTR
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; ZONE ELECTROPHORESIS; AMINO-ACIDS;
   DIPEPTIDES; PROTEINS; PHASE
AB The separation of dipeptides and small peptides by various modes of capillary electrophoresis was investigated in order to identify the best separation conditions and to compare the different charge-to-size parameters used in correlating peptide migration.  For a series of equally charged polyalanines the best linear correlation was obtained when the electrophoretic mobility was plotted against q/(MW)2/3.  Deviations from linearity with other peptides are due to an imprecise charge calculation procedure.  The best separations were achieved at low pH (congruent-to 2.5) when a large metal ion such as Zn++ was added to the buffer.  Under these conditions, peptides are positively charged and differences in charge are maximized.  The separation of peptides at pH 2.5 improved as temperature was decreased.  A set of five 9-residue peptides with no significant difference in charge-to-size ratio were separated at pH 7.0 with a buffer composed of 50 mM Tris + 50 mM DTAB.
RP ISSAQ, HJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,DYNCORP,POB B,FREDERICK,MD 21702, USA.
NR 27
TC 63
Z9 63
U1 1
U2 3
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 6-7
BP 1129
EP 1142
DI 10.1080/10826079208018854
PG 14
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA HP807
UT WOS:A1992HP80700010
ER

PT J
AU ITO, Y
AF ITO, Y
TI SPECULATION ON THE MECHANISM OF UNILATERAL HYDRODYNAMIC DISTRIBUTION OF
   2 IMMISCIBLE SOLVENT PHASES IN THE ROTATING COIL
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID SPEED COUNTERCURRENT CHROMATOGRAPHY; PLANET CENTRIFUGE; BEHAVIOR;
   SYSTEMS
AB The proposed hypothesis is based on the interplay between two force components acting on the fluid in the rotating coil.  The tangential force component generates the Archimedean screw effect to move two solvent phases toward the head of the coil whereas the radial force component acts against the Archimedean force to establish a hydrostatic distribution of the two phases throughout the coil.  The unilateral hydrodynamic distribution of the two phases is governed by the degree of asymmetry in the radial force field on the coil in both simple rotation and synchronous planetary motion.  The present hypothesis successfully explains all the observed hydrodynamic phenomena reported in the past.
RP ITO, Y (reprint author), NHLBI,BETHESDA,MD 20892, USA.
NR 10
TC 21
Z9 24
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2639
EP 2675
DI 10.1080/10826079208016340
PG 37
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000002
ER

PT J
AU OKA, H
   IKAI, Y
   HAYAKAWA, J
   HARADA, K
   NAGASE, K
   SUZUKI, M
   NAKAZAWA, H
   ITO, Y
AF OKA, H
   IKAI, Y
   HAYAKAWA, J
   HARADA, K
   NAGASE, K
   SUZUKI, M
   NAKAZAWA, H
   ITO, Y
TI DISCREPANCY BETWEEN THE THEORETICAL PLATE NUMBER (N) AND PEAK RESOLUTION
   (RS) FOR OPTIMIZING THE FLOW-RATE IN COUNTERCURRENT CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID CENTRIFUGAL
AB This paper deals with a problem in optimizing the flow rate of the mobile phase in countercurrent chromatography (CCC). A set of data including theoretical plate number (N), resolution factor (Rs), % retention, etc. are obtained from the separation of three indole auxins in a two-phase solvent system of n-hexane / ethyl acetate / methanol / water (1:1:1:1) by applying the flow rates of the mobile phase at 0.5 - 8.0ml/min. The experimental results revealed a disagreement between the efficiencies expressed in parameters N and Rs at the high flow rates of the mobile phase in the CCC separation. Namely, the partition efficiency expressed in terms of Rs decreases with an increased flow rate of the mobile phase, while the N rises with increasing the flow rate. Since Rs represents the actual separation of the solute peaks, the results indicate that the N used in high performance liquid chromatography is not always a reliable measure in CCC separation.  However, the application of a high flow rate yields better min/Rs (time in min required to yield Rs=1) than that of a low floe rate.  On the other hand an extremely slow flow rate of the mobile phase results in an abrupt increase of the partition efficiency in terms of both N and Rs.  Therefore, the present findings suggest new strategies to improve the separation efficiency in CCC.
C1 MEIJO UNIV,FAC PHARM,TEMPA,NAGOYA,AICHI 468,JAPAN.
   NATL INST PUBL HLTH,MINATO KU,TOKYO 108,JAPAN.
   NHLBI,BETHESDA,MD 20892.
RP OKA, H (reprint author), AICHI PREFECTURAL INST PUBL HLTH,TSUJI MACHI,KITA KU,NAGOYA 462,JAPAN.
NR 3
TC 9
Z9 9
U1 1
U2 4
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2707
EP 2719
DI 10.1080/10826079208016343
PG 13
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000005
ER

PT J
AU SHIBUSAWA, Y
   ITO, Y
   SLEMP, JL
AF SHIBUSAWA, Y
   ITO, Y
   SLEMP, JL
TI CROSS-AXIS SYNCHRONOUS FLOW-THROUGH COIL PLANET CENTRIFUGE (TYPE XLL)
   .3. PERFORMANCE OF MULTILAYER COILS IN PREPARATIVE SEPARATION OF
   DIPEPTIDES
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID SPEED COUNTERCURRENT CHROMATOGRAPHY
AB Performance of the type-XLL cross-axis coil planet centrifuge with three different size of the multilayer coils was evaluated by separating dipeptide samples on a polar biphasic solvent composed of n-butanol/acetic acid/water (4:1:5, v/v/v). Best results were obtained from the large helical diameter coils with beta values of 1.00-1.20 [1] by eluting with the upper nonaqueous phase at 120 ml/h. The four dipeptides, L-tryptophyl-L-tyrosine, L-leucyl-L-tyrosine, L-valyl-L-tyrosine and L-tyrosylglycine, were completely resolved in 9 hours with high peak resolution (Rs > 1.5).
C1 NHLBI,BETHESDA,MD 20892.
   NIH,BIOMED ENGN & INSTRUMENTAT BRANCH,BETHESDA,MD 20892.
RP SHIBUSAWA, Y (reprint author), TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2735
EP 2750
DI 10.1080/10826079208016345
PG 16
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000007
ER

PT J
AU SHIBUSAWA, Y
   ITO, Y
AF SHIBUSAWA, Y
   ITO, Y
TI COUNTERCURRENT CHROMATOGRAPHY OF PROTEINS WITH POLYETHYLENE
   GLYCOL-DEXTRAN POLYMER PHASE SYSTEMS USING TYPE-XLLL CROSS-AXIS COIL
   PLANET CENTRIFUGE
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID STATIONARY PHASE; RETENTION
AB The performance of a new model of countercurrent chromatograph called the XLLL cross-axis synchronous coil planet centrifuge was evaluated for protein separation. The apparatus produced a satisfactory retention of the stationary phase for the polymer phase systems composed of dextran T500, polyethylene glycol 8000 and potassium phosphate buffers. The capability of the apparatus was demonstrated in separations of histones and serum proteins.
C1 NHLBI,BETHESDA,MD 20892.
RP SHIBUSAWA, Y (reprint author), TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN.
NR 4
TC 27
Z9 29
U1 0
U2 3
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2787
EP 2800
DI 10.1080/10826079208016348
PG 14
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000010
ER

PT J
AU LEE, YW
   SHIBUSAWA, Y
   CHEN, FT
   MYERS, J
   SCHOOLER, JM
   ITO, Y
AF LEE, YW
   SHIBUSAWA, Y
   CHEN, FT
   MYERS, J
   SCHOOLER, JM
   ITO, Y
TI PURIFICATION OF URIDINE PHOSPHORYLASE FROM CRUDE EXTRACTS OF
   ESCHERICHIA-COLI EMPLOYING HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY WITH
   AN AQUEOUS 2-PHASE SOLVENT SYSTEM
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID CENTRIFUGE TYPE-XLL; STATIONARY PHASE; RETENTION; PROTEINS
AB This is a preliminary report on a novel liquid-liquid partitioning chromatography method for the purification of recombinant protein, uridine phosphorylase (UrdPase). This system utilizes an aqueous two-phase solvent system, consisting of polyethylene glycol and phosphate buffer, with a newly developed high-speed countercurrent centrifuge (X-axis, XLL type). The system is capable of purifying crude recombinant UrdPase in an efficient manner.
C1 NHLBI,BETHESDA,MD 20892.
   N CAROLINA CENT UNIV,DEPT CHEM,DURHAM,NC 27707.
RP LEE, YW (reprint author), RES TRIANGLE INST,POB 12194,RES TRIANGLE PK,NC 27709, USA.
NR 18
TC 20
Z9 20
U1 0
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2831
EP 2841
DI 10.1080/10826079208016351
PG 11
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000013
ER

PT J
AU CAI, DG
   GU, MJ
   ZHU, GP
   ZHANG, JD
   ZHANG, TY
   ITO, Y
AF CAI, DG
   GU, MJ
   ZHU, GP
   ZHANG, JD
   ZHANG, TY
   ITO, Y
TI SEMIPREPARATIVE SEPARATION OF ALKALOIDS FROM CEPHALOTAXUS-FORTUNEI
   HOOK-F BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
AB High-speed countercurrent chromatography was applied to the separation of harringtonine, isoharringtonine and homoharringtonine from Cephalotaxus fortunei Hook. f. The separation was performed with a two-phase solvent system composed of chloroform-0.07M sodium phosphate-0.04M citric acid buffer solution (pH 5.0). The fractionated components were identified with authentic pure compounds on TLC and PPC. The peak fraction of each component was analyzed with a mass spectrometer for structure identification. The results indicate that the method is suitable for semipreparative separations of these alkaloids.
C1 BEIJING INST NEW TECHNOL APPL,BEIJING 100035,PEOPLES R CHINA.
   NHLBI,BETHESDA,MD 20892.
RP CAI, DG (reprint author), PLA NAVY,PHARM RES CTR,SHANGHAI 200083,PEOPLES R CHINA.
NR 5
TC 9
Z9 9
U1 0
U2 1
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2873
EP 2881
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000016
ER

PT J
AU MENET, JM
   ROLET, MC
   THIEBAUT, D
   ROSSET, R
   ITO, Y
AF MENET, JM
   ROLET, MC
   THIEBAUT, D
   ROSSET, R
   ITO, Y
TI FUNDAMENTAL CHROMATOGRAPHIC PARAMETERS IN COUNTERCURRENT CHROMATOGRAPHY
   - INFLUENCE OF THE VOLUME OF STATIONARY PHASE AND THE FLOW-RATE
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
AB Two CCC (Countercurrent Chromatography) devices were compared using a test mixture of saturated fatty acids (myristic, palmitic and stearic acids) and the two-phase heptane/acetic acid/methanol solvent system. One device, defined by Dr. ITO as a HDES Type J, is known as a HSCCC (High Speed CCC) apparatus and the other one is defined as a CDCCC (Centrifugal Droplet CCC) HSES. The influence of the rotational speed and the flow-rate on the retention of stationary phase was studied. The variations of capacity factors and resolution against the retention of stationary phase were then plotted and we checked that conventional chromatographic equations can be applied to these curves. Finally a comparison was held between the plots of various chromatographic parameters against the flow-rate between each apparatus and also the ordinary chromatography curves. We also compared the calculated partition coefficients for the fatty acids on each device with the values obtained by the "Dual Mode" method on the CDCCC apparatus and by a scintillation detector used with radioactive fatty acids.
C1 NHLBI, BETHESDA, MD 20892 USA.
RP ECOLE SUPER PHYS & CHIM IND, CHIM ANALYT LAB, 10 RUE VAUQUELIN, F-75231 PARIS 05, FRANCE.
NR 15
TC 16
Z9 16
U1 0
U2 5
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016 USA
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 15-16
BP 2883
EP 2908
DI 10.1080/10826079208016355
PG 26
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA JW130
UT WOS:A1992JW13000017
ER

PT J
AU ISSAQ, HJ
   DELVIKS, K
   JANINI, GM
   MUSCHIK, GM
AF ISSAQ, HJ
   DELVIKS, K
   JANINI, GM
   MUSCHIK, GM
TI CAPILLARY ZONE ELECTROPHORETIC SEPARATION OF HOMOVANILLIC AND
   VANILLYLMANDELIC ACIDS
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID NEURO-BLASTOMA; URINE
AB Capillary zone electrophoresis with untreated fused-silica capillaries and acetate buffer was evaluated for the separation and analysis of catecholamine metabolites. Homovanillic acid and vanillylmandelic acid, which are excreted in abnormally elevated levels in the urine of patients with neuroblastoma, were separated from other possible catecholamine metabolities, using a 200 mM acetate buffer at pH = 4.10. The high buffer concentration was necessary to minimize the peak tailing resulting from analyte-capillary wall interactions. The concentration detection limits of the injected sample at 214 nm were 36 mg/L for vanillylmandelic acid and 64 mg/L for homovanillic acid.
RP ISSAQ, HJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,DYN CORP,PROGRAM RESOURCES INC,POB B,FREDERICK,MD 21702, USA.
RI Delviks-Frankenberry, Krista/M-4822-2013
NR 19
TC 22
Z9 22
U1 0
U2 3
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 18
BP 3193
EP 3201
DI 10.1080/10826079208020878
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA KD935
UT WOS:A1992KD93500002
ER

PT J
AU SUPKO, JG
   MALSPEIS, L
AF SUPKO, JG
   MALSPEIS, L
TI LIQUID-CHROMATOGRAPHIC ANALYSIS OF 9-AMINOCAMPTOTHECIN IN PLASMA
   MONITORED BY FLUORESCENCE INDUCED UPON POSTCOLUMN ACIDIFICATION
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID PLANT ANTITUMOR AGENTS; DNA TOPOISOMERASE-I; CAMPTOTHECIN ANALOGS;
   ANTILEUKEMIC ACTIVITY; BIOLOGICAL-ACTIVITY; NSC-100880
AB Through preclinical studies by the Developmental Therapeutics Program of the National Cancer Institute with 9-amino-20(S)-camptothecin (AC), this new investigational anticancer agent will soon enter phase I clinical trials in cancer patients. During initial attempts to monitor the drug in biological fluids, it became evident that the presence of an amino group on the camptothecin A-ring suppressed the intense native fluorescence characteristic of the unsubstituted compound.  However, subsequent spectrofluorometric studies revealed that the fluorescence of AC was highly pH-dependent in a manner not typically exhibited by aromatic amines. The uncharged species that exists in neutral and weakly acidic solution is nonfluorescent. Protonation of the C-9 amino group proceeds with the development of fluorescence, the intensity of which is optimum in moderately acidic solution of apparent pH 1.7-2.3. Under more strongly acidic conditions, fluorescent intensity again diminishes due to further protonation at the quinoline nitrogen atom. Therefore, postcolumn acidification prior to fluorescence detection provided a convenient and sensitive method to monitor the elution of AC during liquid chromatography. Following protein precipitation induced by mixing with a solution of the internal standard, camptothecin, in methanol chilled to -70-degrees-C, plasma samples were separated on a 5 mum Ultrasphere ODS column (4.6 mm x 25 cm) using an isocratic mobile phase composed of acetonitrile-methanol-0.1 M ammonium acetate buffer, pH 5.5 (23:10:67, v/v/v) at a flow rate of 1.0 ml/min. Prior to detection, the column effluent was mixed inline with 0.3 M aqueous trifluoroacetic acid at a flow rate of 0.3 ml/min and ambient temperature. Fluorescence was then monitored using an excitation wavelength of 352 nm and a 418 nm emission cutoff filter. Typical retention times of the drug and internal standard were 7 and 12 min, respectively. Employing sample volumes of 50 mul, the lowest plasma concentration of AC included in the standard curve, 13.3 nM (5.0 ng/ml) was quantified with a 7.63% coefficient of variation (n = 10).
RP SUPKO, JG (reprint author), NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,PHARMACEUT CHEM LAB,FREDERICK,MD 21702, USA.
NR 28
TC 26
Z9 26
U1 0
U2 0
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 18
BP 3261
EP 3283
DI 10.1080/10826079208020883
PG 23
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA KD935
UT WOS:A1992KD93500007
ER

PT J
AU UTERMAHLEN, WE
   MELLINI, DW
   ISSAQ, HJ
AF UTERMAHLEN, WE
   MELLINI, DW
   ISSAQ, HJ
TI SOLID-PHASE EXTRACTION PROCEDURE FOR THE CLEANUP OF URINE AND
   GASTRIC-JUICE SPECIMENS FOR NITRITE AND NITRATE ANALYSIS BY ION
   CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY
LA English
DT Article
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; THERMAL-ENERGY ANALYZER;
   GAS-CHROMATOGRAPHY; ELECTRODE; SAMPLES; COLUMNS; FOODS
AB A procedure was developed for the clean-up of gastric juice and urine specimens for nitrite and nitrate analysis by ion chromatography.  After dilution with deionized water, the sample is passed through two solid-phase extraction columns (C18 and IC-Ag+) connected in series.  Nitrite and nitrate are eluted off the column and the sample is ready for analysis.  This treatment of the samples eliminates any particles, organics and interfering chloride ions.
C1 NCI,FREDERICK CANC RES & DEV CTR,DYNCORP,PRI,POB B,FREDERICK,MD 21770.
NR 22
TC 11
Z9 11
U1 0
U2 2
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016
SN 0148-3919
J9 J LIQ CHROMATOGR
JI J. Liq. Chromatogr.
PY 1992
VL 15
IS 18
BP 3315
EP 3322
DI 10.1080/10826079208020886
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA KD935
UT WOS:A1992KD93500010
ER

PT J
AU HILBERT, SL
   FERRANS, VJ
AF HILBERT, SL
   FERRANS, VJ
TI PORCINE AORTIC-VALVE BIOPROSTHESES - MORPHOLOGIC AND FUNCTIONAL
   CONSIDERATIONS
SO JOURNAL OF LONG-TERM EFFECTS OF MEDICAL IMPLANTS
LA English
DT Article
DE PORCINE AORTIC VALVE BIOPROSTHESES; MORPHOLOGY; FUNCTION;
   PREIMPLANTATION PROCESSING
ID STRESS-STRAIN; HEART-VALVES; GLUTARALDEHYDE; CALCIFICATION; TISSUE;
   PRESSURE; PROTEINS; COLLAGEN; FATIGUE; FAILURE
AB Porcine aortic valve (PAV) xenografts are the most frequently used type of bioprosthetic (BP) valve for the replacement of damaged or diseased heart valves. Xenograft tissues are routinely crosslinked during manufacturing using low concentrations (i.e., less than 1%) of glutaraldehyde. Crosslinking of xenograft tissue reduces the antigenicity, the rate of in vivo enzymatic degradation, and results in the loss of cell viability. The purpose of this review is to provide an overview of the morphologic and functional properties of the native aortic valve and the effects of tissue harvesting, fixation, anticalcification treatments, and mounting on PAV structure and function. Although efforts have been undertaken to design bioprostheses having increased durability, primary tissue failure still limits the long-term performance of xenograft replacement heart valves.
C1 NHLBI,PATHOL BRANCH,BETHESDA,MD 20894.
RP HILBERT, SL (reprint author), USDA,OFF SCI & TECHNOL,CTR DEVICES & RADIOL HLTH,12200 WILKINS AVE,ROCKVILLE,MD 20852, USA.
NR 37
TC 10
Z9 10
U1 0
U2 2
PU BEGELL HOUSE INC
PI NEW YORK
PA 79 MADISON AVE, SUITE 1205, NEW YORK, NY 10016-7892
SN 1050-6934
J9 J LONG-TERM EFF MED
JI J. Long-Term Eff. Med. Implants
PY 1992
VL 2
IS 2-3
BP 99
EP 112
PG 14
WC Engineering, Biomedical; Medicine, Research & Experimental; Orthopedics;
   Pathology
SC Engineering; Research & Experimental Medicine; Orthopedics; Pathology
GA JW097
UT WOS:A1992JW09700002
PM 10148319
ER

PT J
AU GRZESIEK, S
   IKURA, M
   CLORE, GM
   GRONENBORN, AM
   BAX, A
AF GRZESIEK, S
   IKURA, M
   CLORE, GM
   GRONENBORN, AM
   BAX, A
TI A 3D TRIPLE-RESONANCE NMR TECHNIQUE FOR QUALITATIVE MEASUREMENT OF
   CARBONYL-H-BETA J COUPLINGS IN ISOTOPICALLY ENRICHED PROTEINS
SO JOURNAL OF MAGNETIC RESONANCE
LA English
DT Note
ID MULTIPLE QUANTUM NMR; CONSTANTS; SPECTRA; SPECTROSCOPY; CALMODULIN;
   PROTON; PHASE; C-13; H-1
RP GRZESIEK, S (reprint author), NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892, USA.
RI Clore, G. Marius/A-3511-2008
OI Clore, G. Marius/0000-0003-3809-1027
NR 29
TC 78
Z9 78
U1 1
U2 3
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0022-2364
J9 J MAGN RESON
JI J. Magn. Reson.
PD JAN
PY 1992
VL 96
IS 1
BP 215
EP 221
DI 10.1016/0022-2364(92)90307-S
PG 7
WC Biochemical Research Methods; Physics, Atomic, Molecular & Chemical;
   Spectroscopy
SC Biochemistry & Molecular Biology; Physics; Spectroscopy
GA HB724
UT WOS:A1992HB72400026
ER

PT J
AU MCNELLIS, D
AF MCNELLIS, D
TI A VIEW FROM BETHESDA - INTRODUCTION
SO JOURNAL OF MATERNAL-FETAL INVESTIGATION
LA English
DT Editorial Material
RP MCNELLIS, D (reprint author), NIMH,ROCKVILLE,MD 20857, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0939-6322
J9 J MATERN-FETAL INVES
JI J. Matern.-Fetal Invest.
PY 1992
VL 2
IS 1
BP 3
EP 3
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA HU227
UT WOS:A1992HU22700001
ER

PT J
AU MCNELLIS, D
AF MCNELLIS, D
TI A VIEW FROM BETHESDA - WHYS AND HOWS OF THE NIH RESEARCH GRANT
   APPLICATION
SO JOURNAL OF MATERNAL-FETAL INVESTIGATION
LA English
DT Editorial Material
RP MCNELLIS, D (reprint author), NIH,ROCKVILLE,MD, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0939-6322
J9 J MATERN-FETAL INVES
JI J. Matern.-Fetal Invest.
PY 1992
VL 2
IS 2
BP 69
EP 70
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA JJ327
UT WOS:A1992JJ32700001
ER

PT J
AU ODDS, FC
   ARAI, T
   DISALVO, AF
   EVANS, EGV
   HAY, RJ
   RANDHAWA, HS
   RINALDI, MG
   WALSH, TJ
AF ODDS, FC
   ARAI, T
   DISALVO, AF
   EVANS, EGV
   HAY, RJ
   RANDHAWA, HS
   RINALDI, MG
   WALSH, TJ
TI NOMENCLATURE OF FUNGAL DISEASES - A REPORT AND RECOMMENDATIONS FROM A
   SUB-COMMITTEE OF THE INTERNATIONAL-SOCIETY-FOR-HUMAN-AND-ANIMAL-MYCOLOGY
   (ISHAM)
SO JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY
LA English
DT Article
AB The ISHAM Mycoses Nomenclature Committee has considered the present status of fungal disease names. It suggests that the traditional approach to mycoses nomenclature in which the name of a causative taxon is suffixed with '-asis', '-iasis', '-osis' or '-mycosis' leads to names that are frequently unstable with respect to subsequent taxonomic and clinico-epidemiological changes. It is therefore recommended that individual mycoses should be named as often as possible in the form 'pathology A due to/caused by fungus X' or '[adjectival] fungus X pathology A' in preference to construction of names based solely on fungal taxa. A list of recommended mycosis names retained for their long tradition or intrinsic convenience is provided, together with a combined index and list of rejected names.
C1 BIOTHERAPY RES ASSOC,BUNKYO KU,TOKYO,JAPAN.
   DEPT PATHOL & LAB MED 350,RENO,NV.
   VALLABH BHAI PATEL CHEST INST,DEPT MED MYCOL,DELHI,INDIA.
   UNIV LEEDS,DEPT MICROBIOL,REG MYCOL LAB,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND.
   AUDIE L MURPHY MEM VET ADM MED CTR,AUDIE L MURPHY MEM VET ADM HOSP,LAB SERV 113,SAN ANTONIO,TX 78284.
   NIH,BETHESDA,MD 20892.
   GUYS HOSP,DEPT DERMATOL,LONDON SE1 9RT,ENGLAND.
RP ODDS, FC (reprint author), JANSSEN RES FDN,DEPT BACTERIOL & MYCOL,B-2430 BEERSE,BELGIUM.
NR 3
TC 40
Z9 42
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL
SN 0268-1218
J9 J MED VET MYCOL
JI J. Med. Vet. Mycol.
PY 1992
VL 30
IS 1
BP 1
EP 10
PG 10
WC Mycology
SC Mycology
GA HJ744
UT WOS:A1992HJ74400001
PM 1573518
ER

PT J
AU KWONCHUNG, KJ
   VARMA, A
   EDMAN, JC
   BENNETT, JE
AF KWONCHUNG, KJ
   VARMA, A
   EDMAN, JC
   BENNETT, JE
TI SELECTION OF URA5 AND URA3 MUTANTS FROM THE 2 VARIETIES OF
   CRYPTOCOCCUS-NEOFORMANS ON 5-FLUOROOROTIC ACID-MEDIUM
SO JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY
LA English
DT Article
ID SACCHAROMYCES-CEREVISIAE; YEAST; GENE
AB Spontaneous mutants requiring uracil were isolated from both varieties of Cryptococcus neoformans by plating on 5-fluoroorotic acid (5-FOA) medium. Of the 36 strains tested (18 var. neoformans and 18 var. gattii), 24 (12 of each variety) generated 5-FOA-resistant cells requiring uracil for growth.
   Six of the 12 C. neoformans var. gattii strains produced ura3 cells while the remaining six strains produced ura5 cells. None of the 12 strains produced both ura3 cells and ura5 cells. All 12 isolates of var. neoformans, however, produced ura5 cells and one of them produced ura3 as well as ura5 cells. A genetic lesion in the URA5 gene of an isolate of C. neoformans var. gattii was confirmed by complement with the cognate URA5 gene of C. neoformans var. neoformans The ura3 isolates were tentatively identified by their ability to grow on a medium containing uridine but not on a medium with orotic acid or orotidine. Enzymatic assays for orotidine-5'-phosphate decarboxylase activity confirmed the isolates to be ura3 mutants.
   Hybridization analysis of total DNA, digested with EcoRI or StuI and probed with pURA5g2, revealed the presence of only one copy of URA5 in the strains of either variety, regardless of the prevalence of ura5 mutants. Extensive polymorphism was observed in the restriction patterns of the fragments containing the URA5 locus.
   The prevalence of spontaneously arising ura3 mutants among the isolates of C. neoformans var. gattii, but not among the isolates of C. neoformans var. neoformans, is one more biological difference that distinguishes the two varieties.
C1 UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143.
   UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143.
RP KWONCHUNG, KJ (reprint author), NIAID,CLIN INVEST LAB,BLDG 10,ROOM 11N104,BETHESDA,MD 20892, USA.
NR 12
TC 49
Z9 49
U1 0
U2 3
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL
SN 0268-1218
J9 J MED VET MYCOL
JI J. Med. Vet. Mycol.
PY 1992
VL 30
IS 1
BP 61
EP 69
PG 9
WC Mycology
SC Mycology
GA HJ744
UT WOS:A1992HJ74400007
PM 1573522
ER

PT J
AU LOTT, TJ
   MAGEE, PT
   BARTON, R
   CHU, W
   KWONCHUNG, KJ
   GRINDLE, S
   HOMMA, M
   IWAGUCHI, S
   KELLY, R
   LASKER, BA
   MARRINAN, J
   MONK, B
   KURTZ, MB
   PERLIN, D
   SCHERER, S
   SCHMIDT, D
   TANAKA, K
AF LOTT, TJ
   MAGEE, PT
   BARTON, R
   CHU, W
   KWONCHUNG, KJ
   GRINDLE, S
   HOMMA, M
   IWAGUCHI, S
   KELLY, R
   LASKER, BA
   MARRINAN, J
   MONK, B
   KURTZ, MB
   PERLIN, D
   SCHERER, S
   SCHMIDT, D
   TANAKA, K
TI THE MOLECULAR-GENETICS OF CANDIDA-ALBICANS
SO JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY
LA English
DT Article; Proceedings Paper
CT 11TH CONGRESS OF THE INTERNATIONAL SOC FOR HUMAN AND ANIMAL MYCOLOGY
CY JUN 24-28, 1991
CL MONTREAL, CANADA
SP INT SOC HUMAN & ANIM MYCOL
ID PLASMA-MEMBRANE ATPASE; COLONY MORPHOLOGY; STELLATOIDEA; SEQUENCES;
   YEASTS
C1 PUBL HLTH RES INST CITY NEW YORK INC,NEW YORK,NY 10016.
   NAGOYA UNIV,SCH MED,DIS MECHANISMS & CONTROL RES INST,MED MYCOL LAB,NAGOYA,AICHI 464,JAPAN.
   MERCK INST THERAPEUT RES,RAHWAY,NJ 07065.
   UNIV MINNESOTA,DEPT GENET & CELL BIOL,MINNEAPOLIS,MN 55455.
   UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455.
   NIH,BETHESDA,MD 20892.
RP LOTT, TJ (reprint author), CTR DIS CONTROL,NATL CTR INFECT DIS,DIV BACTERIAL & MYCOT DIS,MYCOT DIS BRANCH,ATLANTA,GA 30333, USA.
NR 23
TC 4
Z9 4
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL
SN 0268-1218
J9 J MED VET MYCOL
JI J. Med. Vet. Mycol.
PY 1992
VL 30
SU 1
BP 77
EP 85
PG 9
WC Mycology
SC Mycology
GA KC681
UT WOS:A1992KC68100010
PM 1474462
ER

PT J
AU KWONCHUNG, KJ
   KOZEL, TR
   EDMAN, JC
   POLACHECK, I
   ELLIS, D
   SHINODA, T
   DROMER, F
AF KWONCHUNG, KJ
   KOZEL, TR
   EDMAN, JC
   POLACHECK, I
   ELLIS, D
   SHINODA, T
   DROMER, F
TI RECENT ADVANCES IN BIOLOGY AND IMMUNOLOGY OF CRYPTOCOCCUS-NEOFORMANS
SO JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY
LA English
DT Article; Proceedings Paper
CT 11TH CONGRESS OF THE INTERNATIONAL SOC FOR HUMAN AND ANIMAL MYCOLOGY
CY JUN 24-28, 1991
CL MONTREAL, CANADA
SP INT SOC HUMAN & ANIM MYCOL
ID MATING-TYPE REGION; MURINE CRYPTOCOCCOSIS; PASSIVE-IMMUNIZATION;
   NEUROSPORA-CRASSA; VAR GATTII; SEROTYPE; ANTIBODY; CLONING; ALLELES;
   ALPHA
C1 UNIV NEVADA,SCH MED,DEPT MICROBIOL,RENO,NV 89557.
   UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143.
   HEBREW UNIV JERUSALEM,HADASSAH MED SCH,IL-91010 JERUSALEM,ISRAEL.
   ADELAIDE CHILDRENS HOSP INC,MYCOL UNIT,ADELAIDE,SA 5006,AUSTRALIA.
   MEIJI COLL PHARM,TOKYO 154,JAPAN.
   HOP COCHIN,F-75674 PARIS 14,FRANCE.
RP KWONCHUNG, KJ (reprint author), NIAID,CLIN INVEST LAB,BETHESDA,MD 20892, USA.
RI Ellis, David/B-3677-2011
NR 31
TC 19
Z9 21
U1 1
U2 1
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL
SN 0268-1218
J9 J MED VET MYCOL
JI J. Med. Vet. Mycol.
PY 1992
VL 30
SU 1
BP 133
EP 142
PG 10
WC Mycology
SC Mycology
GA KC681
UT WOS:A1992KC68100014
PM 1474438
ER

PT J
AU WALSH, TJ
   VANCUTSEM, J
   POLAK, AM
   GRAYBILL, JR
AF WALSH, TJ
   VANCUTSEM, J
   POLAK, AM
   GRAYBILL, JR
TI IMMUNOMODULATION AND ANTIFUNGAL THERAPY OF EXPERIMENTAL INVASIVE
   CANDIDOSIS, HISTOPLASMOSIS AND ASPERGILLOSIS - RECENT ADVANCES AND
   CONCEPTS
SO JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY
LA English
DT Article
ID ACQUIRED IMMUNODEFICIENCY SYNDROME; AMPHOTERICIN-B; COMBINATION THERAPY;
   IMMUNOCOMPROMISED ANIMALS; EXPERIMENTAL CANDIDIASIS; MURINE
   HISTOPLASMOSIS; INTRACELLULAR GROWTH; TISSUE PENETRATION;
   FUNGAL-INFECTIONS; HUMAN MACROPHAGES
C1 JANSSEN RES FDN, BEERSE, BELGIUM.
   F HOFFMANN LA ROCHE & CO LTD, CH-4002 BASEL, SWITZERLAND.
   AUDIE L MURPHY VA MED CTR, SAN ANTONIO, TX USA.
   UNIV TEXAS SAN ANTONIO, SAN ANTONIO, TX 78285 USA.
RP WALSH, TJ (reprint author), NCI, INFECT DIS SECT, BLDG 10, RM 13N-240, BETHESDA, MD 20892 USA.
NR 55
TC 11
Z9 11
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0268-1218
J9 J MED VET MYCOL
JI J. Med. Vet. Mycol.
PY 1992
VL 30
SU 1
BP 225
EP 240
PG 16
WC Mycology
SC Mycology
GA KC681
UT WOS:A1992KC68100023
PM 1474448
ER

PT J
AU SCHWAN, TG
   CORWIN, MD
   BROWN, SJ
AF SCHWAN, TG
   CORWIN, MD
   BROWN, SJ
TI ARGAS (ARGAS) MONOLAKENSIS, NEW SPECIES (ACARI, IXODOIDEA, ARGASIDAE), A
   PARASITE OF CALIFORNIA GULLS ON ISLANDS IN MONO LAKE, CALIFORNIA -
   DESCRIPTION, BIOLOGY, AND LIFE-CYCLE
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE ARACHNIDA; ARGAS-MONOLAKENSIS; MONO LAKE; NEW SPECIES
ID SUBGENUS PERSICARGAS IXODOIDEA; P ARBOREUS KAISER; HOOGSTRAAL; TICKS;
   KOHLS; EGYPT
AB Argas (Argas) monolakensis, n. sp., is described from adults, nymphs, and larvae collected from under and around nests of California gulls, Larus californicus Lawrence, on islands in Mono Lake, Mono County, Calif., and from specimens reared in the laboratory. This species is closely related to A. cooleyi Kohls & Hoogstraal, a parasite of cliff swallows, Hirundo pyrrhonota Vieillot, but is easily distinguished by hypostome dentition and roof of Haller's organ in all stages and chaetotaxy of the larvae. This tick was successfully reared and maintained in the laboratory by feeding them on domestic chickens. Larvae require 5-8 d to feed, whereas all postlarval stages feed rapidly within 9-62 min. At Mono Lake, ticks are aboveground and seek hosts only at night. The number of nymphal stages varies from 2 to 5 depending on the developmental temperature and sex of the tick. Ticks overwinter at Mono Lake as second- to fifth-stage nymphs and adults. Ovarian diapause is common with preoviposition periods in extreme cases lasting up to 20 mo. This tick will readily feed on humans and has the potential to transmit Mono Lake virus, which has been isolated from an estimated 2-8% of ticks on various islands. To date, A. monolakensis is known only from islands in Mono Lake, Calif.
RP SCHWAN, TG (reprint author), NIAID,PUBL HLTH SERV,DEPT HLTH & HUMAN SERV,ARTHROPOD BORNE DIS SECT,HAMILTON,MT 59840, USA.
NR 39
TC 16
Z9 17
U1 1
U2 6
PU ENTOMOL SOC AMER
PI LANHAM
PA 9301 ANNAPOLIS RD, LANHAM, MD 20706
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD JAN
PY 1992
VL 29
IS 1
BP 78
EP 97
PG 20
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA GW982
UT WOS:A1992GW98200015
PM 1552533
ER

PT J
AU AKESON, M
   SCHARFF, J
   SHARP, CM
   NEVILLE, DM
AF AKESON, M
   SCHARFF, J
   SHARP, CM
   NEVILLE, DM
TI EVIDENCE THAT PLASMA-MEMBRANE ELECTRICAL POTENTIAL IS REQUIRED FOR
   VESICULAR STOMATITIS-VIRUS INFECTION OF MDCK CELLS - A STUDY USING
   FLUORESCENCE MEASUREMENTS THROUGH POLYCARBONATE SUPPORTS
SO JOURNAL OF MEMBRANE BIOLOGY
LA English
DT Article
DE MEMBRANE POTENTIAL; VESICULAR STOMATITIS VIRUS; MDCK; CALCIUM; PH
ID CANINE KIDNEY-CELLS; INTRACELLULAR PH; CYTOPLASMIC PH; TRANSPORT;
   FURA-2; CA-2+; ENTRY
AB We used fluorescence microscopy of Madin-Darby Canine Kidney (MDCK) cells grown on polycarbonate filters to study a possible link between plasma membrane electrical potential (DELTA-PSI(pm)) and infectivity of vesicular stomatitis virus (VSV). Complete substitution of K+ for extracellular Na+ blocks VSV infection of MDCK cells as well as baby hamster kidney (BHK) cells. When we independently perfused the apical and basal-lateral surfaces of high resistance monolayers, high K+ inhibited VSV infection of MDCK cells only when applied to the basal-lateral side; high K+ applied apically had no effect on VSV infection. This morphological specificity correlates with a large decrease in DELTA-PSI(pm) of MDCK cells when high K+ buffer is perfused across the basal-lateral surface. Depolarization of the plasma membrane by 130 mm basal K+ causes a sustained increase of cytosol pH in MDCK cells from 7.3 to 7.5 as reported by the fluorescent dye BCECF. Depolarization also causes a transient increase of cytosol Ca2+ from 70 to 300 nM as reported by the dye Fura-2. Neither increase could explain the block of VSV infectivity by plasma membrane depolarization. One alternative hypothesis is that DELTA-PSI(pm) facilitates membrane translocation of viral macromolecules as previously described for colicins, mitochondrial import proteins, and proteins secreted by Escherichia coli.
RP AKESON, M (reprint author), NIMH,BIOPHYS CHEM SECT,MOLEC BIOL LAB,BETHESDA,MD 20892, USA.
NR 28
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0022-2631
J9 J MEMBRANE BIOL
JI J. Membr. Biol.
PD JAN
PY 1992
VL 125
IS 1
BP 81
EP 91
PG 11
WC Biochemistry & Molecular Biology; Cell Biology; Physiology
SC Biochemistry & Molecular Biology; Cell Biology; Physiology
GA HA102
UT WOS:A1992HA10200007
PM 1311768
ER

PT J
AU WOLOZIN, B
   SUNDERLAND, T
   ZHENG, B
   RESAU, J
   DUFY, B
   BARKER, J
   SWERDLOW, R
   COON, H
AF WOLOZIN, B
   SUNDERLAND, T
   ZHENG, B
   RESAU, J
   DUFY, B
   BARKER, J
   SWERDLOW, R
   COON, H
TI CONTINUOUS CULTURE OF NEURONAL CELLS FROM ADULT HUMAN OLFACTORY
   EPITHELIUM
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
ID DIFFERENTIATION; NEUROEPITHELIUM; EXPRESSION; VIMENTIN; CYCLASE; MUCOSA;
   LINE
AB Cells from the olfactory epithelium of adult human cadavers have been propagated in primary culture and subsequently cloned.  These cells exhibit neuronal properties including:  neuron-specific enolase, olfactory marker protein, neurofilaments, and growth-associated protein 43.  Simultaneously, the cells exhibit nonneuronal properties such as glial fibrillary acidic protein and keratin, the latter suggesting properties of neuroblasts or stem cells.  These clonal cultures contain 5-10% of cells sufficiently differentiated to show odorant-dependent cyclic adenosine 3',5'-monophosphate (cAMP) or calcium-release responses when challenged with submicromolar concentrations of odorants.  The potential of culturing neuronal cells from patients with neuropsychiatric disorders, such as Alzheimer's disease or schizophrenia, could enable the study of the pathophysiology of these neurons in the culture dish and allow new approaches to the study of mental illness.
C1 UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201.
   NINCDS,NEUROPHYSIOL LAB,BETHESDA,MD 20892.
   NCI,DIV CANC BIOL & DIAGN,BALTIMORE,MD 21201.
RP WOLOZIN, B (reprint author), NIMH,CLIN SCI LAB,BETHESDA,MD 20892, USA.
OI Wolozin, Benjamin/0000-0003-2068-1475
NR 27
TC 55
Z9 55
U1 0
U2 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512
SN 0895-8696
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PY 1992
VL 3
IS 3
BP 137
EP 146
DI 10.1007/BF02919405
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA HD908
UT WOS:A1992HD90800003
PM 1320921
ER

PT J
AU PROSCHAN, M
   LEYSIEFFER, F
AF PROSCHAN, M
   LEYSIEFFER, F
TI A PARTIAL ORDERING OF RANK DENSITIES
SO JOURNAL OF MULTIVARIATE ANALYSIS
LA English
DT Article
DE ARRANGEMENT INCREASING; PERMUTATION GROUP; RANK DENSITY; PARTIAL
   ORDERING; TESTS OF AGREEMENT BETWEEN RANKINGS; RANKING; AND SELECTION
   PROBLEMS
C1 FLORIDA STATE UNIV, TALLAHASSEE, FL 32306 USA.
RP PROSCHAN, M (reprint author), NHLBI, BETHESDA, MD 20205 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0047-259X
J9 J MULTIVARIATE ANAL
JI J. Multivar. Anal.
PD JAN
PY 1992
VL 40
IS 1
BP 84
EP 93
DI 10.1016/0047-259X(92)90091-S
PG 10
WC Statistics & Probability
SC Mathematics
GA HC788
UT WOS:A1992HC78800005
ER

PT J
AU OBATA, T
   CHIUEH, CC
AF OBATA, T
   CHIUEH, CC
TI INVIVO TRAPPING OF HYDROXYL FREE-RADICALS IN THE STRIATUM UTILIZING
   INTRACRANIAL MICRODIALYSIS PERFUSION OF SALICYLATE - EFFECTS OF MPTP,
   MPDP+, AND MPP+
SO JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
LA English
DT Note
DE MPTP; HYDROXYL RADICAL; DOPAMINE; PARKINSONS DISEASE; SODIUM SALICYLATE
ID PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; LIPID-PEROXIDATION;
   1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP;
   1-METHYL-4-PHENYLPYRIDINIUM MPP+; MANGANESE NEUROTOXICITY;
   DOPAMINERGIC-NEURONS; TRANSITION-METALS; RAT STRIATUM; AUTOXIDATION
AB Increased formation of hydroxyl free radicals (. OH) reflected by . OH adduct of salicylate in brain dialysate was demonstrated during the sustained (more than 2 hours) dopamine overflow elicited by 75 nmol of 1-methyl-4-phenyldihydropyridine (MPDP+) and 1-methyl-4-phenylpyridinium (MPP+) in the rat striatum. Owing to its weak dopamine releasing action, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) did not significantly increase the . OH formation. This data suggests that sustained elevation of dopamine in the extracellular fluid elicited by MPTP analogues can be auto-oxidized, which in turn leads (possibly by indirect mechanisms) to the formation of cytotoxic .OH free radicals near the nigrostriatal terminals.
C1 NIMH,BLDG 10,RM 3D-41,BETHESDA,MD 20892.
   NINCDS,BETHESDA,MD 20892.
NR 37
TC 116
Z9 116
U1 0
U2 0
PU SPRINGER-VERLAG WIEN
PI VIENNA
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA
SN 0300-9564
J9 J NEURAL TRANSM-GEN
JI J. Neural Transm.-Gen. Sect.
PY 1992
VL 89
IS 1-2
BP 139
EP 145
DI 10.1007/BF01245361
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA JM613
UT WOS:A1992JM61300015
PM 1329855
ER

PT J
AU KIRCH, DG
   ALEXANDER, RC
   SUDDATH, RL
   PAPADOPOULOS, NM
   KAUFMANN, CA
   DANIEL, DG
   WYATT, RJ
AF KIRCH, DG
   ALEXANDER, RC
   SUDDATH, RL
   PAPADOPOULOS, NM
   KAUFMANN, CA
   DANIEL, DG
   WYATT, RJ
TI BLOOD-CSF BARRIER PERMEABILITY AND CENTRAL-NERVOUS-SYSTEM
   IMMUNOGLOBULIN-G IN SCHIZOPHRENIA
SO JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
LA English
DT Article
DE BLOOD-CSF BARRIER; ALBUMIN; IMMUNOGLOBULIN-G; SCHIZOPHRENIA
ID CEREBROSPINAL-FLUID; BRAIN-BARRIER; MULTIPLE-SCLEROSIS; IGG SYNTHESIS;
   NEUROLOGICAL DISORDERS; IMMUNE-RESPONSE; ALBUMIN; IMPAIRMENT;
   PRINCIPLES; DISEASES
AB The ratio of albumin in cerebrospinal fluid (CSF) to serum may serve as an index of the integrity of the blood-CSF barrier, with increases in this ratio indicating increased permeability. The ratio of immunoglobulin G (IgG) in CSF to serum (divided by the albumin ratio to correct for variance in blood-CSF permeability) represents an index of the endogenous production of IgG in the central nervous system (CNS), with increases reflecting a possible infectious and/or autoimmune process stimulating central IgG synthesis. We analyzed simultaneously collected CSF and serum samples from 46 schizophrenic subjects, 8 of whom were studied both on and off neuroleptic treatment, and samples from 20 normal controls. The data indicated increases in CSF/serum albumin ratios or CSF/serum IgG indices in 22% and 20%, respectively, of the schizophrenic patients. Only 3 patients showed elevations in both indices. Comparison of values on and off neuroleptics indicated no significant effect of neuroleptics on these indices.
C1 NIMH,CLIN & RES SERV BRANCH,ROCKVILLE,MD 20857.
   NIMH,CHEM SERV,BETHESDA,MD 20892.
RP KIRCH, DG (reprint author), NIMH,DIV CLIN RES,NEUROPHYSIOL BRANCH,5600 FISHERS LANE,ROOM 10-105,ROCKVILLE,MD 20857, USA.
NR 42
TC 28
Z9 28
U1 1
U2 3
PU SPRINGER-VERLAG WIEN
PI VIENNA
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA
SN 0300-9564
J9 J NEURAL TRANSM-GEN
JI J. Neural Transm.-Gen. Sect.
PY 1992
VL 89
IS 3
BP 219
EP 232
DI 10.1007/BF01250674
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA JP657
UT WOS:A1992JP65700008
PM 1389005
ER

PT J
AU GERFEN, CR
AF GERFEN, CR
TI THE NEOSTRIATAL MOSAIC - MULTIPLE LEVELS OF COMPARTMENTAL ORGANIZATION
SO JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
LA English
DT Article; Proceedings Paper
CT WORKSHOP ON THE ADVANCES IN NEUROSCIENCE AND SCHIZOPHRENIA
CY MAY   06, 1991
CL UNIV PITTSBURGH, PITTSBURGH, PA
SP UNIV PITTSBURGH, DEPT PSYCHIAT, UNIV PITTSBURGH, DEPT BEHAV NEUROSCI, UNIV PITTSBURGH, CTR NEUROSCI, LILLY, SANDOZ, UPJOHN, WYETH AYERST
HO UNIV PITTSBURGH
ID NIGRA PARS RETICULATA; D1 DOPAMINE RECEPTOR; SUBSTANTIA-NIGRA;
   OCULOMOTOR FUNCTIONS; GLOBUS PALLIDUS; RAT NEOSTRIATUM; BASAL GANGLIA;
   INTRACELLULAR INJECTION; IMMUNOREACTIVE NEURONS; EFFERENT PROJECTIONS
AB Although schizophrenia may result from disfunction of the cerebral cortex the possible indirect involvement of the basal ganglia may be important as this neural system provides a major neural system through which the cortex affects behavior. Processing of cortical input occurs within the striatum, which is the main component of the basal ganglia. where excitatory cortical imput is transformed to oppositely modulate the output nuclei of the basal ganglia. The details of this transformation, as well as the role of dopamine in this process, are beginning to unfold. Striatal projections to the globus pallidus, through connections with the subthalamic nucleus, modulate excitatory input to the output neurons of the basal ganglia, GABAergic neurons in the internal segment of the globus pallidus and in the substantia nigra, whereas striatal projections directly to these neurons, provide inhibitory inputs. Thus, cortically driven activity in these two striatal output pathways oppositely modulate the output neurons of the basal ganglia. Dopamine appears to play a crucial role in this transformation. D1 and D2 dopamine receptors are specifically expressed by striatonigral and striatopallidal neurons, respectively. The direct action of dopamine through these receptors appears to oppositely modulate the responsiveness of striatal output pathways to cortical input. Insights into the role of dopaminergic function within the basal ganglia may have direct relevance to the development of treatments for schizophrenia.
RP GERFEN, CR (reprint author), NIMH,CELL BIOL LAB,BLDG 36,RM 2D-10,BETHESDA,MD 20892, USA.
NR 69
TC 55
Z9 55
U1 0
U2 3
PU SPRINGER-VERLAG WIEN
PI VIENNA
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA
SN 0300-9564
J9 J NEURAL TRANSM-GEN
JI J. Neural Transm.-Gen. Sect.
PY 1992
SU 36
BP 43
EP 59
PG 17
WC Neurosciences
SC Neurosciences & Neurology
GA JK968
UT WOS:A1992JK96800005
ER

PT J
AU YAMAGUCHI, T
   WINSKY, L
   JACOBOWITZ, DM
AF YAMAGUCHI, T
   WINSKY, L
   JACOBOWITZ, DM
TI EFFECT OF CALRETININ, A NEURONAL CALCIUM-BINDING PROTEIN ON THE
   PHOSPHORYLATION OF NONNEURONAL P2 MEMBRANE-PROTEIN
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 NIMH, HISTOPHARMACOL SECT, BETHESDA, MD 20892 USA.
   TOKYO WOMENS MED COLL, DEPT BIOCHEM, TOKYO 162, JAPAN.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PY 1992
VL 59
SU S
BP S29
EP S29
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA KN476
UT WOS:A1992KN47600168
ER

PT J
AU OGINO, Y
   COSTA, T
AF OGINO, Y
   COSTA, T
TI THE EPITHELIAL PHENOTYPE OF HUMAN NEUROBLASTOMA-CELLS EXPRESSES
   BRADYKININ, ENDOTHELIN, AND ANGIOTENSIN-II RECEPTORS THAT STIMULATE
   PHOSPHOINOSITIDE HYDROLYSIS
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE MUSCARINIC RECEPTORS; ENDOTHELIN RECEPTOR; BRADYKININ RECEPTOR;
   ANGIOTENSIN-II RECEPTOR; FETAL CALF SERUM; PHOSPHOINOSITIDE HYDROLYSIS;
   HUMAN NEUROBLASTOMA CELLS; PHORBOL ESTER; PERTUSSIS TOXIN
ID NEURO-BLASTOMA CELLS; ISLET-ACTIVATING PROTEIN; PERTUSSIS TOXIN;
   PHOSPHOLIPASE-C; PHOSPHATIDYLINOSITOL TURNOVER; ADENYLATE-CYCLASE;
   NG108-15 CELLS; ALPHA-SUBUNITS; PHORBOL ESTER; DNA-SYNTHESIS
AB The neuroblastoma line SK-N-SH consists of distinct and interconverting cell types, which include a neuroblast phenotype (SH-SY5Y), an epithelial phenotype (SH-EP), and an intermediate cell type (SH-IN).  In SH-SY5Y cells, only muscarinic receptor activation produced stimulation of phosphoinositide turnover, whereas in SH-EP cells, where muscarinic receptors are not present, the peptides bradykinin, endothelin, and angiotensin II stimulated phosphoinositide hydrolysis with EC50 values of 16, 6, and 0.7 nM, respectively, and a rank order of maximal effects of bradykinin > endothelin > angiotensin II.  Fetal calf serum at concentrations between 1 and 10% was also a potent stimulator of phosphoinositide hydrolysis in SH-EP cells but not in SH-SY5Y cells.  In the intermediate cell clone, SH-IN, phosphoinositide hydrolysis was stimulated not only by muscarinic receptors, but also by endothelin, bradykinin, and serum, an indication that this cell type harbors all the kinds of receptors that are differentially expressed in the other two cell types.  The effects of the three peptides-bradykinin, endothelin, and angiotensin II-on phosphoinositide hydrolysis in SH-EP cells were additive, a result suggesting that the three kinds of receptors may activate distinct transducer proteins and/or phospholipase C subtypes.  Pretreatment of intact SH-EP cells with pertussis toxin under conditions sufficient to ADP-ribosylate 90-95% of the endogenous guanine nucleotide regulatory protein substrates did not impair the ability of any of the receptors to stimulate phosphoinositide hydrolysis in any of the cell types.  In contrast, short-term exposure to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (1-mu-M) abolished the stimulation of phosphoinositide hydrolysis mediated by peptide receptors in SH-EP cells and partially inhibited that by muscarinic receptors in SH-SY5Y cells.  Prolonged incubation of SH-EP cells with phorbol ester resulted in a recovery of receptor responsiveness, the extent and rate of which were different for each receptor type.  In contrast, there was no recovery of responsiveness for muscarinic receptors in SH-SY5Y cells.  The pattern of phorbol ester-mediated effects depended on the cell rather than on the receptor type.  In fact, muscarinic receptor responsiveness in SH-IN, the intermediate cell type, was desensitized by and recovered from treatment with phorbol esters in a manner more similar to peptide receptors in SH-EP than to muscarinic receptors in SH-SY5Y.  These data suggest that the transduction mechanisms by which distinct receptor types are coupled to phosphoinositide hydrolysis in the three cell phenotypes differ in sensitivity to feedback regulation by protein kinase.
C1 NICHHD,THEORET & PHYS BIOL,BLDG 10,ROOM 6C101,BETHESDA,MD 20892.
OI costa, tommaso/0000-0002-8729-3357
NR 47
TC 21
Z9 22
U1 1
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD JAN
PY 1992
VL 58
IS 1
BP 46
EP 56
DI 10.1111/j.1471-4159.1992.tb09275.x
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA GV354
UT WOS:A1992GV35400004
PM 1309239
ER

PT J
AU MUTOH, T
   RUDKIN, BB
   GUROFF, G
AF MUTOH, T
   RUDKIN, BB
   GUROFF, G
TI DIFFERENTIAL RESPONSES OF THE PHOSPHORYLATION OF RIBOSOMAL PROTEIN-S6 TO
   NERVE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR IN PC12-CELLS
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE NERVE GROWTH FACTOR; PC12; S6
ID SWISS 3T3 CELLS; RAT-LIVER RIBOSOMES; PC12 PHEOCHROMOCYTOMA CELLS;
   SUPERIOR CERVICAL-GANGLIA; SENSITIVE S6 KINASE; SMALL SUBUNIT;
   CYCLIC-AMP; INDEPENDENT PATHWAYS; INITIATION COMPLEX; EMBRYO FIBROBLASTS
AB Previous studies from this laboratory have shown that the phosphorylation of the S6 protein of the ribosomes is catalyzed by at least two different and separable kinase activities in PC12 cells.  One of these activities is increased by treatment of the cells with nerve growth factor, the other by treatment of the cells with epidermal growth factor.  The present work shows that these two factors stimulate the phosphorylation of S6 with quite different kinetics, and that both the number of phosphates incorporated into S6 and the phosphopeptide pattern of S6 are different in cells treated with nerve growth factor than in cells treated with epidermal growth factor.  The characteristics of the nerve growth factor-sensitive S6 kinase and of the epidermal growth factor-sensitive kinase were also clearly different.  Substrate specificity and inhibitor studies indicated that neither was identical to cyclic AMP-dependent kinase, kinase C, or the calcium/calmodulin-dependent kinases.  However, two major phosphopeptides produced by S6 phosphorylation in nerve growth factor-treated cells were also seen on phosphorylation of S6 by cyclic AMP-dependent kinase in vitro.  In addition, when rat liver 40S ribosomal subunits were pretreated with cyclic AMP-dependent kinase in vitro, the action of the nerve growth factor-sensitive S6 kinase was increased about twofold.
C1 NICHHD,GROWTH FACTORS SECT,BLDG 6,ROOM 130,BETHESDA,MD 20892.
NR 55
TC 11
Z9 11
U1 0
U2 2
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD JAN
PY 1992
VL 58
IS 1
BP 175
EP 185
DI 10.1111/j.1471-4159.1992.tb09293.x
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA GV354
UT WOS:A1992GV35400022
PM 1309232
ER

PT J
AU KAUFMAN, EE
   DRISCOLL, BF
AF KAUFMAN, EE
   DRISCOLL, BF
TI CARBON-DIOXIDE FIXATION IN NEURONAL AND ASTROGLIAL CELLS IN CULTURE
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE ASTROGLIA; CO-2 FIXATION; NEURONS; POTASSIUM; FIBROBLASTS; L-GLUTAMATE
ID PYRUVATE-CARBOXYLASE; ALPHA-KETOGLUTARATE; INDUCED STIMULATION;
   OXYGEN-UPTAKE; GLIAL-CELLS; RAT-BRAIN; ASTROCYTES; METABOLISM
AB The concentration of potassium in the extracellular fluid has been found to stimulate the rate of CO2 fixation by astroglial cells grown in primary culture.  Raising the concentration of extracellular potassium increased both the initial rate of formation of the C-14-labeled products of (CO2)-C-14 fixation and the final steady-state level of these products within the cells.  In contrast, neither veratridine nor L-glutamate affected the rate of CO2 fixation in astroglial cells.  The very low rate of CO2 fixation found in primarily neuronal cultures was unaffected by increased extracellular potassium as was CO2 fixation in fibroblasts.  When cultured alone, astroglial cells release a large fraction of the C-14-labeled products of CO2 fixation into the surrounding medium.  Mixed cultures of astroglia and neurons also fix CO2 but, in contrast to astroglia and neurons also fix CO2 but, in contrast to astroglia cultured alone, release only a small fraction of the C-14-labeled products into the culture medium.
RP KAUFMAN, EE (reprint author), NIMH,CEREBRAL METAB LAB,BLDG 36,ROOM 1A05,BETHESDA,MD 20892, USA.
NR 17
TC 71
Z9 72
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD JAN
PY 1992
VL 58
IS 1
BP 258
EP 262
DI 10.1111/j.1471-4159.1992.tb09304.x
PG 5
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA GV354
UT WOS:A1992GV35400033
PM 1727433
ER

PT J
AU YANG, XC
   LABARCA, C
   NARGEOT, J
   HO, BY
   ELROYSTEIN, O
   MOSS, B
   DAVIDSON, N
   LESTER, HA
AF YANG, XC
   LABARCA, C
   NARGEOT, J
   HO, BY
   ELROYSTEIN, O
   MOSS, B
   DAVIDSON, N
   LESTER, HA
TI CELL-SPECIFIC POSTTRANSLATIONAL EVENTS AFFECT FUNCTIONAL EXPRESSION AT
   THE PLASMA-MEMBRANE BUT NOT TETRODOTOXIN SENSITIVITY OF THE RAT-BRAIN
   IIA SODIUM-CHANNEL ALPHA-SUBUNIT EXPRESSED IN MAMMALIAN-CELLS
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID RECOMBINANT VACCINIA VIRUS; NEURO-BLASTOMA CELLS; SKELETAL-MUSCLE; NA+
   CHANNEL; XENOPUS OOCYTES; MESSENGER-RNAS; INACTIVATION; BLOCK;
   PURIFICATION; BIOSYNTHESIS
AB The rat brain IIA Na+ channel alpha-subunit was expressed and studied in mammalian cells. Cells were infected with a recombinant vaccinia virus (VV) carrying the bacteriophage T7 RNA polymerase gene and were transfected with cDNA encoding the IIA Na+ channel alpha-subunit under control of a T7 promoter. Whole-cell patch-clamp recording showed that functional IIA channels were expressed efficiently (approximately 10 channels/mu-m2 in approximately 60% of cells) in Chinese hamster ovary (CHO) cells and in neonatal rat ventricular myocytes but were expressed poorly in undifferentiated BC3H1 cells and failed to express in Ltk- cells. However, voltage-dependent Drosophila Shaker H4 K+ channels and Escherichia coli beta-galactosidase were expressed efficiently in all four cell types with VV vectors. Because RNA synthesis probably occurs without major differences in the cytoplasm of all infected cell types under the control of the T7 promoter and T7 polymerase, we conclude that cell type-specific expression of the Na+ channel probably reflects differences at posttranslational steps. The gating properties of the IIA Na+ currents expressed in cardiac myocytes differed from those expressed in CHO cells; most noticeably, the IIA Na+ currents displayed more rapid macroscopic inactivation when expressed in cardiac myocytes. These differences also suggest cell-specific posttranslational modifications. IIA channels were blocked by approximately 90% by 90 nM TTX when expressed either in CHO cells or in cardiac myocytes; the latter also continued to display endogenous TTX-resistant Na+ currents. Therefore, the TTX binding site of the channel is not affected by cell-specific modifications and is encoded by the primary amino acid sequence.
C1 CALTECH,DIV BIOL 156-29,PASADENA,CA 91125.
   CNRS,CTR BIOCHIM MACROMOLEC,F-34033 MONTPELLIER,FRANCE.
   NIAID,VIRAL DIS LAB,BETHESDA,MD 20892.
FU NIGMS NIH HHS [GM-29836]; NINDS NIH HHS [NS-11756]
NR 55
TC 22
Z9 22
U1 0
U2 1
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JAN
PY 1992
VL 12
IS 1
BP 268
EP 277
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA HA644
UT WOS:A1992HA64400023
PM 1309573
ER

PT J
AU TOCCO, MD
   FUJITA, K
   GUROFF, G
AF TOCCO, MD
   FUJITA, K
   GUROFF, G
TI EFFECT OF DEXAMETHASONE ON THE NERVE GROWTH FACTOR-INDUCED INCREASE IN
   THE NILE GLYCOPROTEIN IN PC12 CELLS
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE PC12; NERVE GROWTH FACTOR; NGF; DEXAMETHASONE; NILE; NG-CAM
ID ADHESION MOLECULE; SCHWANN-CELLS; PHEOCHROMOCYTOMA CELLS; EXTERNAL
   GLYCOPROTEIN; PLASMINOGEN-ACTIVATOR; NEURONAL MIGRATION; FACTOR
   RECEPTORS; SYSTEM; EXPRESSION; RELEASE
AB The long-known and well-documented increase in the NILE glycoprotein produced by nerve growth factor in PC12 cells is prevented by simultaneous treatment with dexamethasone. The absence of this surface marker on the fully differentiated cells has been demonstrated by both glucosamine incorporation and immunohistofluorescence.
C1 NICHHD,GROWTH FACTORS SECT,BETHESDA,MD 20892.
NR 23
TC 1
Z9 1
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0360-4012
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD JAN
PY 1992
VL 31
IS 1
BP 28
EP 32
DI 10.1002/jnr.490310105
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA HA518
UT WOS:A1992HA51800004
PM 1377284
ER

PT J
AU TERMAN, D
AF TERMAN, D
TI THE TRANSITION FROM BURSTING TO CONTINUOUS SPIKING IN EXCITABLE MEMBRANE
   MODELS
SO JOURNAL OF NONLINEAR SCIENCE
LA English
DT Article
DE BURSTING OSCILLATIONS; EXCITABLE MEMBRANES; FIBONACCI DYNAMICS
ID PANCREATIC BETA-CELLS; OSCILLATIONS; ISLETS; CHAOS
AB Mathematical models for excitable membranes may exhibit bursting solutions, and, for different values of the parameters, the bursting solutions give way to continuous spiking. Numerical results have demonstrated that during the transition from bursting to continuous spiking, the system of equations may give rise to very complicated dynamics. The mathematical mechanism responsible for this dynamics is described. We prove that during the transition from bursting to continuous spiking the system must undergo a large number of bifurcations. After each bifurcation the system is increasingly chaotic in the sense that the maximal invariant set of a certain two-dimensional map is topologically equivalent to the shift on a larger set of symbols. The number of symbols is related to the Fibonacci numbers.
C1 NIDDK,MATH RES BRANCH,BETHESDA,MD 20892.
RP TERMAN, D (reprint author), OHIO STATE UNIV,DEPT MATH,COLUMBUS,OH 43210, USA.
NR 18
TC 105
Z9 106
U1 1
U2 3
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8974
J9 J NONLINEAR SCI
JI J. Nonlinear Sci.
PY 1992
VL 2
IS 2
BP 135
EP 182
DI 10.1007/BF02429854
PG 48
WC Mathematics, Applied; Mechanics; Physics, Mathematical
SC Mathematics; Mechanics; Physics
GA HU327
UT WOS:A1992HU32700001
ER

PT J
AU MEREDITH, RF
   KHAZAELI, MB
   PLOTT, WE
   SALEH, MN
   LIU, TP
   ALLEN, LF
   RUSSELL, CD
   ORR, RA
   COLCHER, D
   SCHLOM, J
   SHOCHAT, D
   WHEELER, RH
   LOBUGLIO, AF
AF MEREDITH, RF
   KHAZAELI, MB
   PLOTT, WE
   SALEH, MN
   LIU, TP
   ALLEN, LF
   RUSSELL, CD
   ORR, RA
   COLCHER, D
   SCHLOM, J
   SHOCHAT, D
   WHEELER, RH
   LOBUGLIO, AF
TI PHASE-I TRIAL OF IODINE-131-CHIMERIC B72.3 (HUMAN IGG4) IN METASTATIC
   COLORECTAL-CANCER
SO JOURNAL OF NUCLEAR MEDICINE
LA English
DT Article
ID MONOCLONAL-ANTIBODY B72.3; HUMAN CARCINOMA XENOGRAFTS; GLYCOPROTEIN
   TAG-72; IMMUNE-RESPONSE; OVARIAN-CANCER; ANTIGEN;
   RADIOIMMUNOLOCALIZATION; RADIOIMMUNODETECTION; ADENOCARCINOMA;
   LOCALIZATION
AB Twelve patients with metastatic colorectal cancer participated in a Phase I trial of I-131-labeled chimeric B72.3 (human IgG4). Consecutive groups of patients received 18 mCi/m2, 27 mCi/m2 and 36 mCi/m2. No acute side effects related to antibody administration were noted. Bone marrow suppression was the only side effect; it was dose-dependent and correlated with whole-body radiation dose estimates. The lowest dose level produced no marrow suppression, whereas 27 mCi/m2 resulted in Grade 1 and 2 marrow suppression in two of three patients. The maximum tolerated dose was 36 mCi/m2 with all six patients at this dose level having at least Grade I and two patients with Grade 3 and 4 marrow suppression. Eight of 12 patients had radioimmune imaging of tumor sites at 5-22 days. Seven patients had an antibody response to initial infusion. On retreatment, whole-body kinetics and imaging were altered for patients with a high anti-ch-B72.3 response. Thus, chimeric B72.3 (IgG4) has limited utility as a means of delivering multiple therapeutic doses of I-131 in the majority of patients; alternative strategies including second generation anti-TAG-72 monoclonal antibodies, other radioisotopes and other chimeric human isotypes will need to be pursued.
C1 UNIV ALABAMA,CTR COMPREHENS CANC,DEPT RADIAT ONCOL,BIRMINGHAM,AL 35294.
   UNIV ALABAMA,CTR COMPREHENS CANC,DEPT MED,BIRMINGHAM,AL 35294.
   UNIV ALABAMA,CTR COMPREHENS CANC,DEPT NUCL MED,BIRMINGHAM,AL 35294.
   NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892.
   AMER CYANAMID CO,PEARL RIVER,NY.
FU NCI NIH HHS [CM87215, CA45232]; NCRR NIH HHS [M01-RR-00032]
NR 43
TC 81
Z9 81
U1 0
U2 0
PU SOC NUCLEAR MEDICINE INC
PI RESTON
PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316
SN 0161-5505
J9 J NUCL MED
JI J. Nucl. Med.
PD JAN
PY 1992
VL 33
IS 1
BP 23
EP 29
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA GY676
UT WOS:A1992GY67600011
PM 1730991
ER

PT J
AU AVERY, A
   PARASKEVA, C
   SPORN, M
   MOORGHEN, M
AF AVERY, A
   PARASKEVA, C
   SPORN, M
   MOORGHEN, M
TI ROLE FOR TRANSFORMING GROWTH-FACTOR-BETA IN AUTOCRINE GROWTH-CONTROL IN
   THE HUMAN COLON
SO JOURNAL OF PATHOLOGY
LA English
DT Meeting Abstract
C1 UNIV BRISTOL,SCH MED SCI,DEPT PATHOL & MICROBIOL,BRISTOL BS8 1TH,AVON,ENGLAND.
   NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS LTD
PI W SUSSEX
PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD
SN 0022-3417
J9 J PATHOL
JI J. Pathol.
PY 1992
VL 168
SU S
BP A141
EP A141
PG 1
WC Oncology; Pathology
SC Oncology; Pathology
GA JT657
UT WOS:A1992JT65700193
ER

PT J
AU TAFFS, RE
   SITKOVSKY, MV
AF TAFFS, RE
   SITKOVSKY, MV
TI MODULATION OF THE EFFECTOR FUNCTIONS OF CYTOLYTIC LYMPHOCYTES-T WITH
   SYNTHETIC PEPTIDE INHIBITORS OF PROTEIN-KINASES
SO JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
ID LIGHT-CHAIN KINASE; PSEUDOSUBSTRATE PROTOTYPE; SUBSTRATE-SPECIFICITY;
   REGULATORY DOMAIN; BASIC RESIDUES; C CONTAINS; PHOSPHORYLATION;
   ACTIVATION; RECEPTOR; REQUIREMENTS
AB The hypothesis was tested that it is possible to influence cellular responses of intact cells using synthetic peptide substrates, pseudosubstrates, and inhibitors of protein kinases.  Using cytotoxic T-cells (CTL), we demonstrate here that some basic amino acid-containing synthetic peptide substrates of protein kinases [e.g., of cGMP-dependent protein kinase (peptide PKG-S), synthetic peptide inhibitor of cGMP-dependent protein kinase (peptide PKG-I), and peptide corresponding to the tyrosine phosphorylation site in pp60src (peptide RR-src)] were strongly inhibitory in T-cell receptor (TCR) and T-cell growth factor, interleukin 2 (IL-2)-triggered proliferation of CTL.  These peptides also inhibited other cellular responses of CTL.  Peptides which contain basic amino acids, but do not have substrate specificity determinants for protein kinase, were not inhibitory.  The inhibition with peptides is not due to their toxicity, since no cell death was observed by the trypan blue exclusion test and by lactate dehydrogenase release.  Use of the granule exocytosis assay provided opportunities to clarify the mechanism of the peptide action.  Tested peptides inhibited not only cell-surface ligand-induced CTL activation, but also affected cell-surface receptor-independent CTL activation (granule exocytosis and gamma-interferon secretion) induced by the synergistic action of the protein kinase C activator (PMA) and ionophore A23187.  It was found that minor changes in amino acid composition or amino acid position in the synthetic peptides dramatically change their ability to affect lymphocytes.  Pretreatment with peptide PKG-S at 37-degrees-C, but not at 22 or 4-degrees-C, for at least 90 min, followed by washing, was sufficient to observe inhibition of CTL function (a small effect was observed even after 60 min of pretreatment).  Results of the peptide binding and of intracellular localization studies support the view that studied peptides exert their effect after gaining access to the cell interior.  Percoll gradient fractionation of CTL disrupted by nitrogen cavitation revealed that the largest proportion of radiolabel was in cytosol.  The requirement for the relatively high concentration of peptides needed to demonstrate their effects may reflect their partial degradation by peptidases.  The presented data support the model in which specific features of amino acid composition allow for the peptide internalization and interference with cellular functions.
C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
NR 30
TC 6
Z9 6
U1 0
U2 0
PU AMER PHARMACEUTICAL ASSN
PI WASHINGTON
PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037
SN 0022-3549
J9 J PHARM SCI
JI J. Pharm. Sci.
PD JAN
PY 1992
VL 81
IS 1
BP 37
EP 44
DI 10.1002/jps.2600810108
PG 8
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
SC Pharmacology & Pharmacy; Chemistry
GA GY159
UT WOS:A1992GY15900007
PM 1619567
ER

PT J
AU PAULE, MG
   ALLEN, RR
   BAILEY, JR
   SCALLET, AC
   ALI, SF
   BROWN, RM
   SLIKKER, W
AF PAULE, MG
   ALLEN, RR
   BAILEY, JR
   SCALLET, AC
   ALI, SF
   BROWN, RM
   SLIKKER, W
TI CHRONIC MARIJUANA SMOKE EXPOSURE IN THE RHESUS-MONKEY .2. EFFECTS ON
   PROGRESSIVE RATIO AND CONDITIONED POSITION RESPONDING
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID PROLONGED CANNABIS TREATMENT; MARIHUANA USE; AMOTIVATIONAL SYNDROME;
   OPERANT ACQUISITION; COSTA-RICA; DELTA-9-TETRAHYDROCANNABINOL;
   PERFORMANCE; BEHAVIOR; COCAINE; MEMORY
AB Sixty-two male rhesus monkeys were trained to respond in an operant test battery that included tasks thought to allow measurement of aspects of motivation and color and position discrimination.  Subjects were assigned to eight treatment groups (n = 7-8) based upon behavioral performance.  There were two behavioral groups:  ACTIVE = behavior assessed throughout the 365 days of active exposure and beyond, and RESIDUAL = behavior assessed beginning 2 months after the last exposure.  Each behavioral group had four dose groups:  HI = smoke from one marijuana (MJ) cigarette/day 7 days/week; LO = MJ smoke only on weekends; EX = smoke from one extracted MJ (placebo) cigarette/day 7 days/week; SH = sham exposure 7 days/week.  For the motivation task, both HI and LO ACTIVE groups earned significantly fewer reinforcers than did both ACTIVE control groups during the last several months of exposure.  These effects disappeared within 2 to 3 months of cessation of treatment, and no similar effect was present when RESIDUAL groups were tested.  Performance of the color and position discrimination task was adversely affected in one of eight HI ACTIVE subjects throughout most of the chronic exposure, and there was a trend toward residual deficits in performance of this task in the HI RESIDUAL group compared to both SH and EX RESIDUAL controls.  These data could be interpreted to mean that during periods of chronic use, MJ produces an amotivational-like syndrome in rhesus monkeys and that this syndrome disappears only several weeks to months after the last exposure.
C1 NATL CTR TOXICOL RES,COMP BASED SYST INC,JEFFERSON,AR 72079.
   UNIV ARKANSAS MED SCI HOSP,DEPT PHARMACOL & TOXICOL,LITTLE ROCK,AR 72205.
   UNIV ARKANSAS MED SCI HOSP,DEPT PEDIAT,LITTLE ROCK,AR 72205.
   ARKANSAS CHILDRENS HOSP,LITTLE ROCK,AR 72202.
   UNIV ARKANSAS MED SCI HOSP,DEPT PHYSIOL & BIOPHYS,LITTLE ROCK,AR 72205.
   UNIV ARKANSAS MED SCI HOSP,DEPT BIOCHEM & MOLEC BIOL,LITTLE ROCK,AR 72205.
   NIDA,DIV PRECLIN RES,NEUROSCI RES BRANCH,ROCKVILLE,MD.
RP PAULE, MG (reprint author), NATL CTR TOXICOL RES,DIV REPROD & DEV TOXICOL,PHARMACODYNAM BRANCH,PRIMATE RES FACIL,JEFFERSON,AR 72079, USA.
FU NIA NIH HHS [IAG 224-83-005]
NR 67
TC 39
Z9 39
U1 1
U2 1
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JAN
PY 1992
VL 260
IS 1
BP 210
EP 222
PG 13
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA GZ451
UT WOS:A1992GZ45100029
PM 1731038
ER

PT J
AU MACARTHUR, L
   IACANGELO, AL
   HSU, CM
   EIDEN, LE
AF MACARTHUR, L
   IACANGELO, AL
   HSU, CM
   EIDEN, LE
TI ENKEPHALIN BIOSYNTHESIS IS COUPLED TO SECRETORY ACTIVITY VIA
   TRANSCRIPTION OF THE PROENKEPHALIN-A GENE
SO JOURNAL OF PHYSIOLOGY-PARIS
LA English
DT Article
DE ENKEPHALIN; TRANSCRIPTION; CHROMAFFIN; SECRETION
ID ADRENAL CHROMAFFIN CELLS; MESSENGER-RNA LEVELS; CHROMOGRANIN-A;
   CYCLIC-AMP; BOVINE CHROMOGRANIN; PROTEIN-KINASE; ADENOSINE
   3',5'-MONOPHOSPHATE; CONTAINING PEPTIDES; NERVOUS-SYSTEM; DNA ELEMENTS
AB The molecular mechanisms regulating neuropeptide and secretory protein biosynthesis in neuroendocrine cells were examined using the prototype neuropeptide and secretory proteins enkephalin and chromogranin A (CGA). Treatment with the secretogogue nicotine results in the calcium-dependent secretion of enkephalin peptides from bovine chromaffin cells in primary culture and a concomitant increase in enkephalin peptide biosynthesis. Both secretion and biosynthesis are also stimulated by cell depolarization with elevated potassium. Elevation of intracellular cyclic AMP, on the other hand, results in stimulation of enkephalin biosynthesis and long-term, but not acute, secretion of enkephalin peptides. Coupling of enkephalin biosynthesis to calcium influx occurs at the level of transcription of the enkephalin gene. Thus, potassium depolarization causes a calcium-dependent elevation of enkephalin mRNA which is preceded by an increase in the rate of transcription of the enkephalin gene in the chromaffin cell. The accumulation of enkephalin message or peptide by potassium depolarization or treatment with nicotine is prevented by D600 or hexamethonium respectively, added 1 h after addition of nicotine or KCl and following acute release, suggesting that calcium acts as a continuous rather than triggering stimulus for enkephalin biosynthesis. Sequence analysis of the bovine enkephalin promoter identified sequence conservation of three enhancers previously reported in the human gene which are required for regulation of the gene by calcium, cAMP and phorbol ester in vitro. In contrast to the regulation of the enkephalin system, no increase in either CGA or CGB mRNA or gene transcription attended depolarization-induced secretion from chromaffin cells. Since enkephalin and CGA are co-stored in and co-released from the same secretory vesicles in these cells, the results imply that a surplus of CGA is constitutively synthesized in chromaffin cells such that compensatory up-regulation during changes in the secretory state of the cell, such as occurs for enkephalin, is not required for the secretory proteins.
RP MACARTHUR, L (reprint author), NIMH,CELL BIOL LAB,BLDG 36,ROOM 3A-17,BETHESDA,MD 20892, USA.
NR 62
TC 8
Z9 8
U1 0
U2 0
PU EDITIONS SCIENTIFIQUES ELSEVIER
PI PARIS CEDEX 15
PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE
SN 0928-4257
J9 J PHYSIOLOGY-PARIS
JI J. Physiol.-Paris
PY 1992
VL 86
IS 1-3
BP 89
EP 98
DI 10.1016/S0928-4257(05)80012-9
PG 10
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA KQ851
UT WOS:A1992KQ85100011
PM 1364196
ER

PT J
AU AKISKAL, HS
AF AKISKAL, HS
TI THE MANAGEMENT OF TREATMENT-RESISTANT AFFECTIVE-DISORDER - CLINICAL
   PERSPECTIVES - COMMENTARY
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE AFFECTIVE DISORDERS; TREATMENT-RESISTANT; COMMENTARY
C1 NIMH, AFFECT & RELATED DISORDERS, ROCKVILLE, MD 20857 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PY 1992
VL 6
IS 2
BP 156
EP 156
DI 10.1177/026988119200600202
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JM105
UT WOS:A1992JM10500002
PM 22291341
ER

PT J
AU POTTER, WZ
   MANJI, HK
AF POTTER, WZ
   MANJI, HK
TI COMMENTARY ON THE MANAGEMENT OF TREATMENT-RESISTANT AFFECTIVE-DISORDER -
   CLINICAL PERSPECTIVES
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE AFFECTIVE DISORDERS; TREATMENT-RESISTANT; DIAGNOSIS; COMMENTARY
ID FOLLOW-UP; DEPRESSION; PREDICTORS; THERAPY; MANIA
C1 NIMH, EXPTL BRANCH, CLIN PHARMACOL SECT, BETHESDA, MD 20892 USA.
NR 14
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PY 1992
VL 6
IS 2
BP 164
EP 166
DI 10.1177/026988119200600207
PG 3
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JM105
UT WOS:A1992JM10500007
PM 22291346
ER

PT J
AU KINGMAN, A
AF KINGMAN, A
TI STATISTICAL VS CLINICAL-SIGNIFICANCE IN PRODUCT TESTING - CAN THEY BE
   DESIGNED TO SATISFY EQUIVALENCE
SO JOURNAL OF PUBLIC HEALTH DENTISTRY
LA English
DT Article
ID COMPARATIVE BIOAVAILABILITY TRIALS
AB Statistical issues associated with demonstrating significance between treatment groups (efficacy or superiority) and nonsignificance (equivalence) are presented and discussed. Methodologies for demonstrating efficacy of a product are proposed and contrasted, incorporating clinical and statistical criteria, with emphasis on situations in which placebo groups are precluded from the study design. Distinctions are drawn between study designs for demonstrating superiority and those for equivalence, including the determination of sample sizes needed for the different approaches. The "at least as good as" criterion is proposed as a reasonable alternative to that of equivalence in active control equivalence studies for demonstrating that dental product modifications or new products are efficacious.
RP KINGMAN, A (reprint author), NIDR,EPIDEMIOL & ORAL DIS PREVENT PROGRAM,5333 WESTBARD AVE,ROOM 525,BETHESDA,MD 20816, USA.
NR 11
TC 10
Z9 10
U1 0
U2 0
PU AAPHD NATIONAL OFFICE
PI RICHMOND
PA J PUBLIC HEALTH DENT 10619 JOUSTING LANE, RICHMOND, VA 23235
SN 0022-4006
J9 J PUBLIC HEALTH DENT
JI J. Public Health Dent.
PY 1992
VL 52
IS 6
SI SI
BP 353
EP 360
DI 10.1111/j.1752-7325.1992.tb02303.x
PG 8
WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
   Health
SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
   Health
GA JX394
UT WOS:A1992JX39400008
PM 1432923
ER

PT J
AU SCHIODT, M
   ATKINSON, JC
   GREENSPAN, D
   FOX, PC
   DODD, CL
   DANIELS, TE
   GREENSPAN, JS
AF SCHIODT, M
   ATKINSON, JC
   GREENSPAN, D
   FOX, PC
   DODD, CL
   DANIELS, TE
   GREENSPAN, JS
TI SIALOCHEMISTRY IN HUMAN-IMMUNODEFICIENCY-VIRUS ASSOCIATED SALIVARY-GLAND
   DISEASE
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE SALIVA; AIDS; SJOGRENS SYNDROME; HIV-1; SALIVARY GLANDS; XEROSTOMIA
ID PRIMARY SJOGRENS-SYNDROME; CIRCULATING IMMUNE-COMPLEXES; BONE-MARROW
   TRANSPLANTATION; AIDS-RELATED COMPLEX; RHEUMATOID FACTORS; SICCA
   SYNDROME; PAROTID-GLAND; INFECTION; IGA; AUTOANTIBODIES
AB Human immunodeficiency virus (HIV) associated salivary gland disease is defined as the presence of enlargement of one or more major salivary glands and/or diminished salivary function in an HIV infected individual. It has a number of similarities to, as well as differences from, Sjogren's syndrome (SS). We studied the sialochemistry of stimulated parotid saliva of 11 patients with HIV associated salivary gland disease ad bilateral parotid gland enlargement, and compared these findings with those of 15 HIV negative controls, 13 HIV positive individuals with no salivary gland involvement and 18 individuals with SS. The patients with HIV associated salivary gland disease had a significant decrease in the level of salivary protein, with increases in salivary IgA, lysozyme and albumin compared to the HIV negative controls. There were no changes in concentration of electrolytes. The sialochemistry among the patients with HIV associated salivary gland disease was unrelated to the degree of immune suppression and did not change over a 6 month period. The observed changes were similar to those of SS but less pronounced. The similar clinical, histologic and sialochemical features of HIV associated salivary gland disease and SS suggest that these conditions share common pathogenetic mechanisms, which may be modified in the former by the HIV infection.
C1 FREDERIKSBORG CENT CTY HOSP,DEPT ORAL SURG,DK-3400 HILLEROD,DENMARK.
   UNIV CALIF SAN FRANCISCO,CTR ORAL AIDS,DEPT STOMATOL,SAN FRANCISCO,CA 94143.
   UNIV HOSP & ROYAL DENT COLL,COPENHAGEN,DENMARK.
   NIDR,CLIN INVEST & PATIENT CARE BRANCH,BETHESDA,MD 20892.
FU NIDCR NIH HHS [P01-DE07946]
NR 28
TC 13
Z9 13
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA
SN 0315-162X
J9 J RHEUMATOL
JI J. Rheumatol.
PD JAN
PY 1992
VL 19
IS 1
BP 26
EP 29
PG 4
WC Rheumatology
SC Rheumatology
GA HF289
UT WOS:A1992HF28900007
PM 1556696
ER

PT J
AU SILVER, RM
   SUTHERLAND, SE
   CARREIRA, P
   HEYES, MP
AF SILVER, RM
   SUTHERLAND, SE
   CARREIRA, P
   HEYES, MP
TI ALTERATIONS IN TRYPTOPHAN-METABOLISM IN THE TOXIC OIL SYNDROME AND IN
   THE EOSINOPHILIA-MYALGIA-SYNDROME
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE TOXIC OIL SYNDROME; EOSINOPHILIA-MYALGIA SYNDROME; L-TRYPTOPHAN;
   METABOLISM
ID INDOLEAMINE 2,3-DIOXYGENASE; GAMMA-INTERFERON; SCLERODERMA-LIKE;
   QUINOLINIC ACID; INGESTION; INDUCTION; DIOXYGENASE; FIBROBLASTS;
   KYNURENINE; CARBIDOPA
AB The eosinophilia-myalgia syndrome (EMS) was associated with ingestion of L-tryptophan containing products and was accompanied by altered metabolism of L-tryptophan during the active phase. Many patients with EMS exhibited clinical and histopathological features similar to another epidemic, the toxic oil syndrome (TOS), associated with ingestion of adulterated rapeseed oil. We hypothesized that patients with TOS, like patients with EMS, may have had altered metabolism of L-tryptophan during the acute phase of the illness. Therefore, we quantitated the tryptophan metabolites, L-kynurenine and quinolinic acid, and we measured neopterin, a marker of interferon-gamma (IFN-gamma), in blood obtained during the acute phase of each syndrome. Patients with TOS or EMS had significantly higher L-kynurenine and quinolinic acid than healthy control subjects or rheumatic disease control subjects. Neopterin was also elevated in patients with untreated TOS and EMS, and correlated strongly with L-kynurenine and quinolinic acid. Our data suggest that indoleamine-2, 3-dioxygenase (IDO), the rate limiting enzyme of the kynurenine pathway of L-tryptophan metabolism, was activated in both syndromes by cytokines including IFN-gamma, and that perhaps products of tryptophan metabolism played a role in the pathogenesis of EMS and TOS.
C1 MED UNIV S CAROLINA,DEPT BIOSTAT EPIDEMIOL & SYST SCI,CHARLESTON,SC 29425.
   HOSP 12 OCTUBRE,SERV REUMATOL,MADRID,SPAIN.
   NIMH,ANALYT CHEM SECT,CLIN SCI LAB,BETHESDA,MD 20892.
RP SILVER, RM (reprint author), MED UNIV S CAROLINA,DEPT MED,DIV RHEUMATOL & IMMUNOL,ROOM 912,CLIN SCI BLDG,171 ASHLEY AVE,CHARLESTON,SC 29425, USA.
FU NCRR NIH HHS [RR01070-13]
NR 39
TC 27
Z9 27
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA
SN 0315-162X
J9 J RHEUMATOL
JI J. Rheumatol.
PD JAN
PY 1992
VL 19
IS 1
BP 69
EP 73
PG 5
WC Rheumatology
SC Rheumatology
GA HF289
UT WOS:A1992HF28900015
PM 1532618
ER

PT J
AU OCONNELL, PG
   GERBER, LH
   DIGIOVANNA, JJ
   PECK, GL
AF OCONNELL, PG
   GERBER, LH
   DIGIOVANNA, JJ
   PECK, GL
TI ARTHRITIS IN PATIENTS WITH PSORIASIS TREATED WITH GAMMA-INTERFERON
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE INTERFERONS; ARTHRITIS; PSORIASIS
ID RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; IA ANTIGENS; INDUCTION;
   KERATINOCYTES; PLACEBO; RAT
AB We observed 3 patients with psoriasis who developed arthritis during treatment of psoriatic skin disease with intramuscular recombinant human gamma-interferon (IFN-gamma). Symptoms primarily involved the hands, feet, shoulders, and neck. One patient had acute plantar fasciitis. Routine laboratory studies were unrevealing. Patients presented with symptoms initially between the 10th and 12th weeks of treatment and the arthritis resolved after cessation of IFN-gamma. One patient was subsequently retreated with IFN-gamma for 4 weeks and had a temporary recurrence of arthritis with an associated rise and fall of his articular index.
C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892.
RP OCONNELL, PG (reprint author), NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT REHABIL MED,BLDG 10,6S 235,BETHESDA,MD 20892, USA.
NR 19
TC 26
Z9 26
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA
SN 0315-162X
J9 J RHEUMATOL
JI J. Rheumatol.
PD JAN
PY 1992
VL 19
IS 1
BP 80
EP 82
PG 3
WC Rheumatology
SC Rheumatology
GA HF289
UT WOS:A1992HF28900017
PM 1556705
ER

PT J
AU ASHERY, RS
AF ASHERY, RS
TI ISSUES IN AIDS TRAINING FOR SUBSTANCE-ABUSE WORKERS
SO JOURNAL OF SUBSTANCE ABUSE TREATMENT
LA English
DT Article
DE TRAINING; EDUCATION; AIDS EDUCATION TRAINING; COUNSELORS; DRUG TREATMENT
   PROGRAMS
AB Workers in drug treatment programs need specialized training concerning acquired immune deficiency syndrome (AIDS) to meet the demands of their expanding roles. Initially, the treatment community failed to anticipate training needs fully, but now, comprehensive and systematic AIDS training programs must be developed. This article discusses the five steps in developing and implementing such programs: (a) assessment and information gathering, (b) curriculum development, (c) training of instructors, (d) training delivery, and (e) evaluation.
RP ASHERY, RS (reprint author), NIDA,MENTAL HLTH ADM,COMMUNITY RES BRANCH,5600 FISHERS LANE,ROOM 9A-30,ROCKVILLE,MD 20857, USA.
NR 11
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0740-5472
J9 J SUBST ABUSE TREAT
JI J. Subst. Abus. Treat.
PY 1992
VL 9
IS 1
BP 15
EP 19
DI 10.1016/0740-5472(92)90005-9
PG 5
WC Psychology, Clinical; Substance Abuse
SC Psychology; Substance Abuse
GA HR005
UT WOS:A1992HR00500003
PM 1593660
ER

PT J
AU RADKEYARROW, M
   NOTTELMANN, E
   MARTINEZ, P
   FOX, MB
   BELMONT, B
AF RADKEYARROW, M
   NOTTELMANN, E
   MARTINEZ, P
   FOX, MB
   BELMONT, B
TI YOUNG-CHILDREN OF AFFECTIVELY ILL PARENTS - A LONGITUDINAL-STUDY OF
   PSYCHOSOCIAL DEVELOPMENT
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE DEVELOPMENTAL COURSE; AFFECTIVELY ILL PARENTS; OFFSPRING OF DEPRESSED
   PARENTS; CHILD ASSESSMENT
ID AFFECTIVE-DISORDERS; PSYCHOPATHOLOGY; DEPRESSION; DIAGNOSES; SEVERITY;
   RISK
AB The course of social-emotional development of young children of affectively ill and well parents was assessed. The families were classified by mother's diagnosis: bipolar illness (N = 22), unipolar depression (N = 41), and normal (N = 37). Father's diagnosis also was obtained. Pairs of siblings were studied; the younger was between 1 1/2 and 3 1/2 years and the older between 5 and 8 years when the study began. They were seen again 3 years later. Psychiatric assessment and mother's report were used to evaluate children's disruptive behavior, anxiety, and depressive characteristics. The frequency of problem-level behavior changed over time in relation to mother's diagnosis. By middle and late childhood, significantly more children of affectively ill than well mothers had depressive and disruptive problems and multiple behavior problems. Offspring of unipolar mothers developed problems earlier and both siblings were more likely to have behavior problems.
RP RADKEYARROW, M (reprint author), NIMH,15-K,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 32
TC 131
Z9 133
U1 0
U2 9
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JAN
PY 1992
VL 31
IS 1
BP 68
EP 77
DI 10.1097/00004583-199201000-00011
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA GZ437
UT WOS:A1992GZ43700011
PM 1537784
ER

PT J
AU PANZA, JA
   PETRONE, RK
   FANANAPAZIR, L
   MARON, BJ
AF PANZA, JA
   PETRONE, RK
   FANANAPAZIR, L
   MARON, BJ
TI UTILITY OF CONTINUOUS WAVE DOPPLER ECHOCARDIOGRAPHY IN THE NONINVASIVE
   ASSESSMENT OF LEFT-VENTRICULAR OUTFLOW TRACT PRESSURE-GRADIENT IN
   PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID TWO-DIMENSIONAL ECHOCARDIOGRAPHY; SYSTOLIC ANTERIOR MOTION; M-MODE
   ECHOCARDIOGRAPHY; SUBAORTIC STENOSIS; MITRAL-STENOSIS; AORTIC-STENOSIS;
   WIDE-ANGLE; PATTERNS; IDENTIFICATION; ABNORMALITIES
AB Subaortic obstruction is an important determinant of the clinical presentation of and therapeutic approach to patients with hypertrophic cardiomyopathy.  Therefore, assessment of the presence and magnitude of the intraventricular pressure gradient is paramount in the clinical evaluation of these patients.  To establish the utility of continuous wave Doppler echocardiography in assessing the pressure gradient in hypertrophic cardiomyopathy, 28 patients representing the wide hemodynamic spectrum of this disease underwent simultaneous determination of the subaortic gradient by continuous wave Doppler ultrasound and cardiac catheterization.
   With use of the modified Bernoulli equation, the Doppler-estimated gradient showed a strong correlation with the maximal instantaneous pressure difference measured at catheterization, both under basal conditions (r = 0.93; p < 0.0001) and during provocative maneuvers (r = 0.89; p < 0.0001).  In 26 of the 28 patients, all assessments of the subaortic gradient were in agreement within 15 mm Hg (average difference 5 +/- 3 mm Hg).  In the other two patients there were substantial differences between these measurements (under basal conditions in one patient and after provocation in another), although the Doppler technique predicted the presence of marked subaortic obstruction in each.  In both patients the erroneous interpretation was due to superimposition of the mitral regurgitation signal on that of left ventricular outflow.
   Doppler waveforms from the left ventricular outflow tract showed variability in contour among different patients and in individual patients.  Hence, continuous wave Doppler echocardiography is a useful noninvasive method for estimating the subaortic gradient in patients with hypertrophic cardiomyopathy.  However, technical factors such as contamination of the outflow tract jet with that of mitral regurgitation and variability in waveform configuration may importantly influence such assessments of the subaortic gradient.
RP PANZA, JA (reprint author), NHLBI,CARDIOL BRANCH,ECHOCARDIOG LAB,BLDG 10,ROOM 7B-15,BETHESDA,MD 20892, USA.
NR 29
TC 127
Z9 133
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JAN
PY 1992
VL 19
IS 1
BP 91
EP 99
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA GX836
UT WOS:A1992GX83600015
PM 1729351
ER

PT J
AU LAUER, MS
   ANDERSON, KM
   LEVY, D
AF LAUER, MS
   ANDERSON, KM
   LEVY, D
TI SEPARATE AND JOINT INFLUENCES OF OBESITY AND MILD HYPERTENSION ON
   LEFT-VENTRICULAR MASS AND GEOMETRY - THE FRAMINGHAM HEART-STUDY
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID BLOOD-PRESSURE RESPONSE; CARDIOVASCULAR-DISEASE; CARDIAC ADAPTATION;
   HYPERTROPHY; PREVALENCE; RISK; POPULATION; CRITERIA; STRESS; SIZE
AB Increased left ventricular mass has been shown to be a significant independent predictor of cardiovascular risk.  The purpose of this study was to assess the separate and combined relations of obesity and hypertension with left ventricular mass and geometry.
   Echocardiographic findings in subjects in the Framingham Heart Study who were free of cardiopulmonary disease and were not taking cardiovascular medications were examined.  M-mode studies that were evaluate for estimating left ventricular mass were available in 624 men and 1,209 women.  Height and weight measured at the time of echocardiography were used to calculate body mass index (in kg/m2), a measure of obesity.  Casual sitting blood pressure measurements were obtained to detect rest hypertension.
   In subgroup analyses of lean normotensive, obese normotensive, lean hypertensive and obese hypertensive subjects, hypertension and obesity each had significant independent associations with left ventricular mass and wall thickness (all p < 0.001 in men and women).  Obesity was also associated with left ventricular internal diameter (p < 0.001 in men and women).  There were no synergistic influences of hypertension and obesity on any echocardiographic left ventricular variables.
   It is concluded that obesity and hypertension each have distinct associations with left ventricular mass and geometry.  These strengths of association are additive but not synergistic.
C1 NHLBI,FRAMINGHAM HEART STUDY,5 THURBER ST,FRAMINGHAM,MA 01701.
   HARVARD UNIV,SCH MED,BOSTON,MA 02115.
   HARVARD UNIV,BETH ISRAEL HOSP,THORNDIKE LAB,BOSTON,MA 02215.
   BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215.
   BETH ISRAEL HOSP,DEPT MED,DIV CARDIOVASC,BOSTON,MA 02215.
RI Lauer, Michael/L-9656-2013
OI Lauer, Michael/0000-0002-9217-8177
FU NHLBI NIH HHS [N01-HC-38038, HL07374]
NR 36
TC 118
Z9 123
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JAN
PY 1992
VL 19
IS 1
BP 130
EP 134
PG 5
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA GX836
UT WOS:A1992GX83600021
PM 1729324
ER

PT J
AU SHIP, JA
AF SHIP, JA
TI ORAL HEALTH OF PATIENTS WITH ALZHEIMERS-DISEASE
SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
LA English
DT Article
ID DESTRUCTIVE PERIODONTAL-DISEASE; POSITRON EMISSION TOMOGRAPHY;
   SUBMANDIBULAR SALIVARY FLOW; DIFFERENT AGE-GROUPS; ROOT CARIES;
   GLUCOSE-UTILIZATION; DENTAL-HEALTH; POPULATION; MANAGEMENT; DEMENTIA
AB Generally healthy, unmedicated patients with Alzheimer's disease have few but significant changes in their oral health. Study results reinforce preventive oral hygiene for these patients.
RP SHIP, JA (reprint author), NIDR,9000 ROCKVILLE PIKE,BLDG 10,ROOM IN-113,BETHESDA,MD 20892, USA.
NR 51
TC 40
Z9 43
U1 4
U2 6
PU AMER DENTAL ASSN
PI CHICAGO
PA 211 E CHICAGO AVE, CHICAGO, IL 60611
SN 0002-8177
J9 J AM DENT ASSOC
JI J. Am. Dent. Assoc.
PD JAN
PY 1992
VL 123
IS 1
BP 53
EP 58
PG 6
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA GY354
UT WOS:A1992GY35400016
PM 1740573
ER

PT J
AU COLE, JS
   GRUBER, J
AF COLE, JS
   GRUBER, J
TI PROGRESS AND PROSPECTS FOR HUMAN CANCER VACCINES
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID TUMOR-INFILTRATING LYMPHOCYTES; MONOCLONAL-ANTIBODIES; ANTIGEN
   PRESENTATION; ENVELOPE PROTEIN; GENE-TRANSFER; T-CELLS; INTERLEUKIN-2;
   MELANOMA; RECOGNITION; B72.3
RP COLE, JS (reprint author), NCI,DIV CANC ETIOL,BIOL CARCINOGENESIS PROGRAM,BETHESDA,MD 20892, USA.
NR 35
TC 8
Z9 8
U1 0
U2 1
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD JAN 1
PY 1992
VL 84
IS 1
BP 18
EP 23
DI 10.1093/jnci/84.1.18
PG 6
WC Oncology
SC Oncology
GA HG722
UT WOS:A1992HG72200009
PM 1346654
ER

PT J
AU GART, JJ
AF GART, JJ
TI THE IDENTITY OF ARMITAGES 2 TESTS OF HETEROGENEITY OF PROPORTIONS FOR
   PROPORTIONAL SUBCLASS-NUMBERS
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL
LA English
DT Article
DE BINOMIAL DISTRIBUTION; PARTIAL ASSOCIATION; PEARSON CHI-2-TEST
AB Armitage discusses two chi-2-tests for heterogeneity of proportions after adjustment for stratification. One is based on a quadratic form of the deviations from expected values and the other is a more easily calculated Pearson chi-2-test. We show, for proportional subclass numbers (or balanced designs), that the two test statistics are identical.
RP GART, JJ (reprint author), NCI,MATH STAT & APPL MATH SECT,BIOSTAT BRANCH,EPN 407,BETHESDA,MD 20892, USA.
NR 4
TC 1
Z9 1
U1 1
U2 1
PU BLACKWELL PUBL LTD
PI OXFORD
PA 108 COWLEY RD, OXFORD, OXON, ENGLAND OX4 1JF
SN 0035-9246
J9 J ROY STAT SOC B MET
JI J. R. Stat. Soc. Ser. B-Methodol.
PY 1992
VL 54
IS 1
BP 185
EP 187
PG 3
WC Statistics & Probability
SC Mathematics
GA HB292
UT WOS:A1992HB29200008
ER

PT J
AU GART, JJ
AF GART, JJ
TI POOLING 2X2 TABLES - ASYMPTOTIC MOMENTS OF ESTIMATORS
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL
LA English
DT Article
DE ODDS RATIO; POOLING; 2-BY-2 TABLES
ID INTERVAL ESTIMATION; CONTINGENCY-TABLES; COLLAPSIBILITY; COMBINATION
AB Consider J independent pairs of mutually independent binomial variates which can be considered as J2 x 2 tables.  We assume a common measure of association, such as the odds ratio, between the tables.  This paper studies the asymptotic moments of the 'pooled' estimators, i.e. those constructed from the data summed over all the tables.  For balanced designs, or proportional subclass numbers, it is shown that the pooled estimator of the common odds ratio is asymptotically biased towards 1, while those of the common ratio and difference are asymptotically unbiased.  The asymptotic variances are also compared.  A simple test for complete homogeneity is suggested.  The various results are illustrated in numerical examples.
RP GART, JJ (reprint author), NCI,BIOSTAT BRANCH,EPN 407,BETHESDA,MD 20892, USA.
NR 24
TC 3
Z9 3
U1 1
U2 1
PU BLACKWELL PUBL LTD
PI OXFORD
PA 108 COWLEY RD, OXFORD, OXON, ENGLAND OX4 1JF
SN 0035-9246
J9 J ROY STAT SOC B MET
JI J. R. Stat. Soc. Ser. B-Methodol.
PY 1992
VL 54
IS 2
BP 531
EP 539
PG 9
WC Statistics & Probability
SC Mathematics
GA HL620
UT WOS:A1992HL62000011
ER

PT J
AU SPENCER, WF
   LINEHAN, WM
   WALTHER, MM
   HAAS, GP
   LOTZE, MT
   TOPALIAN, SL
   YANG, JC
   MERINO, MJ
   LANGE, JR
   POCKAJ, BA
   ROSENBERG, SA
AF SPENCER, WF
   LINEHAN, WM
   WALTHER, MM
   HAAS, GP
   LOTZE, MT
   TOPALIAN, SL
   YANG, JC
   MERINO, MJ
   LANGE, JR
   POCKAJ, BA
   ROSENBERG, SA
TI IMMUNOTHERAPY WITH INTERLEUKIN-2 AND ALPHA-INTERFERON IN PATIENTS WITH
   METASTATIC RENAL-CELL CANCER WITH INSITU PRIMARY CANCERS - A PILOT-STUDY
SO JOURNAL OF UROLOGY
LA English
DT Article
DE CARCINOMA, RENAL CELL; KIDNEY NEOPLASMS; IMMUNOTHERAPY; INTERFERON
   TYPE-I; INTERLEUKIN-2
ID HIGH-DOSE INTERLEUKIN-2; ACTIVATED KILLER-CELLS; THERAPY
AB A total of 12 patients with stage 4 renal cell carcinoma and primary renal tumors in situ was entered into a pilot study using treatment with interleukin-2 and alpha-interferon followed by radical nephrectomy.  Of the patients 11 underwent nephrectomy after an initial course of immunotherapy.  Ten patients were able to receive a second course of immunotherapy given after nephrectomy.  One patient achieved a complete response of lung and mediastinal metastases without any change in the primary renal tumor but after nephrectomy the patient remained in complete remission for greater than 11 months.  A total of 3 patients achieved a partial response at some extrarenal sites but they had progression elsewhere.  Toxicity was similar to previous experience with this immunotherapy regimen.  Therefore, we demonstrated that metastatic tumor regression is possible with primary renal tumors in situ and that aggressive interleukin-2-based immunotherapy can be tolerated in the presence of a large renal tumor.
RP SPENCER, WF (reprint author), NCI,DIV CANC TREATMENT,SURG BRANCH,BETHESDA,MD 20892, USA.
NR 7
TC 46
Z9 46
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD JAN
PY 1992
VL 147
IS 1
BP 24
EP 30
PG 7
WC Urology & Nephrology
SC Urology & Nephrology
GA GX782
UT WOS:A1992GX78200005
PM 1729540
ER

PT J
AU RUSCETTI, S
   AURIGEMMA, R
   YUAN, CC
   SAWYER, S
   BLAIR, DG
AF RUSCETTI, S
   AURIGEMMA, R
   YUAN, CC
   SAWYER, S
   BLAIR, DG
TI INDUCTION OF ERYTHROPOIETIN RESPONSIVENESS IN MURINE HEMATOPOIETIC-CELLS
   BY THE GAG-MYB-ETS-CONTAINING ME26 VIRUS
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID PUTATIVE ONCOGENE SPI-1; AVIAN LEUKEMIA-VIRUS; FOCUS-FORMING VIRUS;
   DNA-BINDING FACTOR; TRANSCRIPTIONAL ACTIVATION; ENVELOPE GENE;
   TRANSFORMATION; EXPRESSION; RECEPTOR; E26
AB ME26 virus, which was generated by inserting the coding region of the acute avian leukemia-inducing virus E26 into a murine retrovirus vector, encodes a 135-kDa gag-myb-ets fusion protein.  Amphotropic murine leukemia virus pseudotypes of ME26 virus induce a high incidence of erythroleukemia 2 to 4 months after injection into newborn NFS/N mice.  Spleen cells from the majority of these mice proliferate to high levels in the presence of the erythroid hormone erythropoietin (Epo) and can easily be established as permanent Epo-dependent cell lines.  The cell lines contain multiple copies of ME26 viral DNA and express viral message and protein.  An Epo receptor mRNA of normal size can be detected in these cells, and binding studies reveal a single class of lower-affinity Epo receptor with an affinity for Epo that is in the range of that previously reported for erythroid cells.  The ME26 virus-induced Epo-dependent cell lines, however, appear more immature than previously described erythroid cell lines and more closely resemble early hematopoietic precursor cells, suggesting that the virus may be activating the Epo receptor in hematopoietic cells that do not normally express it.  Consistent with this idea, we are able to infect an interleukin-3-dependent myeloid cell line, FDC-P2, with ME26 virus and convert it to Epo dependence.  The ME26 virus-infected FDC-P2 cells, even before growth on Epo, showed a large increase in the amount of Epo receptor mRNA.  However, no ME26 viral integrations can be detected adjacent to the Epo receptor gene, indicating that the virus is not activating the Epo receptor gene by promoter/enhancer insertion.  Our results are more consistent with the hypothesis that the gag-myb-ets-encoded viral fusion protein, which is known to bind DNA, is directly or indirectly activating the expression of the Epo receptor gene in these cells.
C1 VANDERBILT UNIV,NASHVILLE,TN 37232.
RP RUSCETTI, S (reprint author), NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702, USA.
FU NIDDK NIH HHS [DK 39781]
NR 33
TC 17
Z9 17
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 20
EP 26
PG 7
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100004
PM 1309243
ER

PT J
AU DIMITROV, DS
   HILLMAN, K
   MANISCHEWITZ, J
   BLUMENTHAL, R
   GOLDING, H
AF DIMITROV, DS
   HILLMAN, K
   MANISCHEWITZ, J
   BLUMENTHAL, R
   GOLDING, H
TI KINETICS OF SOLUBLE CD4 BINDING TO CELLS EXPRESSING
   HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HTLV-III/LAV ENVELOPE; AIDS-RELATED COMPLEX; SYNCYTIUM FORMATION; T4
   MOLECULE; HIV; INFECTION; RECEPTOR; INVITRO; PROTEIN; FUSION
AB The high-affinity interaction between the envelope glycoprotein (gp120-gp41) of the human immunodeficiency virus type 1 and its receptor, CD4, is important for viral entry into cells and therapeutical approaches based on the soluble form of CD4 (sCD4).  Using flow cytometry, we studied the kinetics of binding of sCD4 to gp120-gp41 expressed on the cell surface.  sCD4 binding was dependent on sCD4 concentration and temperature and exhibited bimolecular reaction kinetics.  Binding was very slow at low sCD4 concentrations (below 0.2-mu-g/ml) and low temperatures (below 13-degrees-C) but increased sharply with increasing temperature.  The rate constant for association at 37-degrees-C (1.5 x 10(5) M-1 s-1) was 14-fold higher than at 4-degrees-C, but the affinity of sCD4 to membrane-bound gp120-gp41 was not significantly affected.  The activation energy at higher temperatures (28 to 37-degrees-C) was less than at lower temperatures (4 to 13-degrees-C).  After long periods of incubation, we observed a decrease of surface-bound sCD4 and gp120, even at low temperatures, which was attributed to sCD4-induced shedding of gp120.  The rate of gp120 shedding was much lower than the rate of sCD4 binding and was dependent on sCD4 concentration and temperature.  The finding that sCD4 binding is slow, especially at low sCD4 concentrations, can be of critical importance for efficient blocking of viral infection by sCD4 and should be considered when designing new protocols in the therapy of AIDS patients.
C1 US FDA,CTR BIOL EVALUAT & RES,DIV VIROL,BETHESDA,MD 20892.
   NCI,MEMBRANE STRUCT & FUNCT SECT,BETHESDA,MD 20892.
NR 32
TC 44
Z9 44
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 132
EP 138
PG 7
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100017
PM 1727475
ER

PT J
AU BERKHOUT, B
   JEANG, KT
AF BERKHOUT, B
   JEANG, KT
TI FUNCTIONAL ROLES FOR THE TATA PROMOTER AND ENHANCERS IN BASAL AND
   TAT-INDUCED EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG
   TERMINAL REPEAT
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID RNA POLYMERASE-II; ACTIVATION-RESPONSIVE REGION; HIV-1 TAT;
   TRANSCRIPTIONAL ACTIVATION; REGULATORY SEQUENCES; TRANS-ACTIVATOR;
   NUCLEAR-PROTEIN; HSP70 PROMOTER; DNA-SEQUENCES; BINDING-SITES
AB We have analyzed the contributory role of the human immunodeficiency virus type 1 (HIV-1) promoter and enhancers in basal and Tat-induced transcription.  We found that a minimal promoter competent for basal expression is contained within sequences spanning nucleotides -43 to +80.  Basal expression from this HIV-1 promoter was boosted more by the additional presence of the NF-kappa-B elements than by the Sp1 elements.  The minimal long terminal repeat promoter (-43 to +80), while having an intact TAR sequence, was not Tat inducible.  However, the simple addition of short synthetic enhancer motifs (AP1, Oct, Sp1, and NF-kappa-B) conferred Tat responsiveness.  This ability to respond to Tat was in part dependent on the presence of the HIV-1 promoter.  Changing the HIV-1 TATA to other eucaryotic TATA or non-TATA initiators minimally affected basal expression but altered Tat inducibility.  Our findings suggest a specific context of functional promoter and enhancer elements that is optimal for Tat trans activation of the HIV-1 long terminal repeat.  Our results do not allow conclusions about whether Tat acts at the level of initiation or at the level of elongation to be drawn.
C1 NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892.
RI Jeang, Kuan-Teh/A-2424-2008
NR 74
TC 223
Z9 225
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 139
EP 149
PG 11
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100018
PM 1727476
ER

PT J
AU SCHWARTZ, S
   FELBER, BK
   PAVLAKIS, GN
AF SCHWARTZ, S
   FELBER, BK
   PAVLAKIS, GN
TI DISTINCT RNA SEQUENCES IN THE GAG REGION OF HUMAN-IMMUNODEFICIENCY-VIRUS
   TYPE-1 DECREASE RNA STABILITY AND INHIBIT EXPRESSION IN THE ABSENCE OF
   REV PROTEIN
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID VIRAL MESSENGER-RNA; TRANS-ACTIVATOR; MAMMALIAN-CELLS; GENE-PRODUCT;
   ENZYMATIC AMPLIFICATION; RESPONSIVE ELEMENT; TARGET SEQUENCE; HTLV-I;
   ENV; CIS
AB The expression of Gag, Pol, Vif, Vpr, Vpu, and Env proteins from unspliced and partially spliced human immunodeficiency virus type 1 (HIV-1) mRNAs depends on the viral protein Rev, while the production of Tat, Rev, and Nef from multiply spliced mRNAs does not require Rev.  To investigate the difference between gag and tat mRNAs, we generated plasmids expressing tat-gag hybrid mRNAs.  Insertion of the gag gene downstream of the tat open reading frame in the tat cDNA resulted in the inhibition of Tat production.  This inhibition was caused, at least in part, by a decrease in the stability of the produced mRNA.  Deletions in gag defined a 218-nucleotide inhibitory sequence named INS-1 and located at the 5' end of the gag gene.  Further experiments indicated the presence of more than one inhibitory sequence in the gag-protease gene region of the viral genome.  The inhibitory effect of INS-1 was counteracted by the positive effect mediated by the Rev-Rev-responsive element interaction, indicating that this sequence is important for Rev-regulated gag expression.  The INS-1 sequence did not contain any known HIV-1 splice sites and acted independently of splicing.  It was found to have an unusually high AU content (61.5% AU), a common feature among cellular mRNAs with short half-lives.  These results suggest that HIV-1 and possibly other lentiviruses have evolved to express unstable mRNAs which require additional regulatory factors for their expression.  This strategy may offer the virus several advantages, including the ability to enter a state of low or latent expression in the host.
C1 NCI,FREDERICK CANC RES & DEV CTR,HUMAN RETROVIRUS SECT,ABL BASIC RES PROGRAM,FREDERICK,MD 21702.
   NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,HUMAN RETROVIRUS PATHOGENESIS GRP,FREDERICK,MD 21762.
   KAROLINSKA INST,DEPT VIROL,S-10401 STOCKHOLM 60,SWEDEN.
FU NCI NIH HHS [N01-CO-74101]
NR 69
TC 243
Z9 246
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 150
EP 159
PG 10
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100019
PM 1727477
ER

PT J
AU HAIGWOOD, NL
   NARA, PL
   BROOKS, E
   VANNEST, GA
   OTT, G
   HIGGINS, KW
   DUNLOP, N
   SCANDELLA, CJ
   EICHBERG, JW
   STEIMER, KS
AF HAIGWOOD, NL
   NARA, PL
   BROOKS, E
   VANNEST, GA
   OTT, G
   HIGGINS, KW
   DUNLOP, N
   SCANDELLA, CJ
   EICHBERG, JW
   STEIMER, KS
TI NATIVE BUT NOT DENATURED RECOMBINANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
   GP120 GENERATES BROAD-SPECTRUM NEUTRALIZING ANTIBODIES IN BABOONS
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID NUCLEOTIDE-SEQUENCE ANALYSIS; ENVELOPE GLYCOPROTEIN GP120; SEROLOGICAL
   RESPONSES; IMMUNE-RESPONSE; HTLV-III/LAV; CHIMPANZEES; HIV-1; INFECTION;
   VACCINE; DETERMINANT
AB The protection of individuals from human immunodeficiency virus type 1 (HIV-1) infection with an envelope subunit derived from a single isolate will require the presentation of conserved epitopes in gp120.  The objective of the studies presented here was to test whether a native recombinant gp120 (rgp120) immunogen would elicit responses to conserved neutralization epitopes that are not present in a denatured recombinant gp120 antigen from the same virus isolate.  In a large study of 51 baboons, we have generated heterologous neutralizing activity with native, glycosylated rgp120SF2 but not with denatured, nonglycosylated env 2-3SF2.  After repeated exposure to rgp120SF2 formulated with one of several adjuvants, virus isolates from the United States, the Caribbean, and Africa were neutralized.  The timing of the immunization regimen and the choice of adjuvant affected the virus neutralization titers both quantitatively and qualitatively.  These results suggest that vaccination with native, glycosylated rgp120 from a single virus isolate, HIV-SF2, may elicit a protective immune response effective against geographically and sequentially distinct HIV-1 isolates.
C1 NCI,FREDERICK CANC RES FACIL,VIRUS BIOL SECT,FREDERICK,MD 21701.
   SW FDN BIOMED RES,SAN ANTONIO,TX 78284.
RP HAIGWOOD, NL (reprint author), CHIRON CORP,4560 HORTON ST,EMERYVILLE,CA 94608, USA.
NR 54
TC 151
Z9 152
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 172
EP 182
PG 11
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100022
PM 1727480
ER

PT J
AU WILLEY, RL
   MALDARELLI, F
   MARTIN, MA
   STREBEL, K
AF WILLEY, RL
   MALDARELLI, F
   MARTIN, MA
   STREBEL, K
TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VPU PROTEIN REGULATES THE FORMATION
   OF INTRACELLULAR GP160-CD4 COMPLEXES
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID LONG TERMINAL REPEAT; ENDOPLASMIC-RETICULUM; SOLUBLE CD4; AIDS;
   INFECTION; RECEPTOR; HIV-1; CELLS; GENE; DNA
AB Intracellular transport and processing of the human immunodeficiency virus type 1 (HIV-1) envelope precursor glycoprotein, gp160, proceeds via the endoplasmic reticulum and Golgi complex and involves proteolytic processing of gp160 into the mature virion components, gp120 and gp41.  We found that coexpression of gp160 and human CD4 in HeLa cells severely impaired gp120 production due to the formation of intracellular gp160-CD4 complexes.  This CD4-mediated inhibition of gp160 processing was alleviated by coexpression of the HIV-1-encoded Vpu protein.  The coexpression of Vpu and CD4 in the presence of gp160 resulted in increased degradation of CD4.  Although the precise mechanism(s) responsible for the Vpu effect is presently unclear, our findings suggest that Vpu may destabilize intracellular gp160-CD4 complexes.
C1 NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892.
NR 31
TC 224
Z9 227
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 226
EP 234
PG 9
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100028
PM 1727486
ER

PT J
AU GREEN, KY
   KAPIKIAN, AZ
AF GREEN, KY
   KAPIKIAN, AZ
TI IDENTIFICATION OF VP7 EPITOPES ASSOCIATED WITH PROTECTION AGAINST HUMAN
   ROTAVIRUS ILLNESS OR SHEDDING IN VOLUNTEERS
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID SEROTYPE-SPECIFIC NEUTRALIZATION; NUCLEOTIDE-SEQUENCE ANALYSIS;
   RHESUS-ROTAVIRUS; BOVINE ROTAVIRUS; MONOCLONAL-ANTIBODIES; VACCINE;
   INFANTS; EFFICACY; CHILDREN; DIARRHEA
AB Sera from 17 of 18 adult volunteers challenged with a virulent serotype 1 rotavirus strain (D) were examined for prechallenge antibody levels against several well-defined rotavirus VP7 and VP4 neutralization epitopes by a competitive epitope-blocking immunoassay (EBA) in order to determine whether correlates of resistance to diarrheal illness could be identified.  The presence of prechallenge serum antibody at a titer of greater-than-or-equal-to 1:20 that blocked the binding of a serotype 1 VP7-specific monoclonal antibody (designated 2C9) that maps to amino acid residue 94 in antigenic site A on the serotype 1 VP7 was significantly associated with resistance to illness or shedding (P < 0.001) or illness and shedding (P < 0.01) following challenge with the serotype 1 virus.  In addition, an EBA antibody titer of greater-than-or-equal-to 1:20 in prechallenge serum against a serotype 3 VP7-specific epitope (defined by monoclonal antibody 954/159) that maps to amino acid 94 on the serotype 3 VP7 was also significantly associated with resistance to illness or shedding (P = 0.02), with a trend for protection against illness and shedding.  A trend was also noted between the presence of EBA antibody against a cross-reactive VP4 epitope common to many human rotavirus strains, including the challenge virus, or a rhesus monkey rotavirus strain-specific VP4 antigenic site, and resistance to illness or shedding.  These data confirm that the presence of serum antibody correlates with resistance to rotavirus illness or shedding but, in addition, demonstrate the association of antibody to a specific epitope with resistance to illness or shedding.  These data also suggest that antigenic site A on the rotavirus VP7, composed of amino acids 87 to 96, may be involved in the formation of a major protective epitope.  Further study of the role of this epitope in the development of homotypic and heterotypic immunity to rotaviruses following natural or vaccine-induced infection may be important in the development of strategies for control of rotavirus diarrheal disease.
RP GREEN, KY (reprint author), NIAID,INFECT DIS LAB,EPIDEMIOL SECT,BETHESDA,MD 20892, USA.
NR 46
TC 42
Z9 44
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 548
EP 553
PG 6
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100064
PM 1370092
ER

PT J
AU GHOSH, D
AF GHOSH, D
TI GLUCOCORTICOID RECEPTOR-BINDING SITE IN THE HUMAN-IMMUNODEFICIENCY-VIRUS
   LONG TERMINAL REPEAT
SO JOURNAL OF VIROLOGY
LA English
DT Note
ID NEGATIVE REGULATORY ELEMENT; DNA-BINDING; TRANSCRIPTION FACTOR; T-CELLS;
   MEDIATED TRANSCRIPTION; PROTEIN BINDS; HTLV-III; TYPE-1; HIV; ACTIVATION
AB Previous reports (P. D. Katsanakis, C. E. Sekaris, and D. A. Spandidos, Anticancer Res. 11:381-383, 1991; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; R. Miksicek, A. Heber, W. Schmid, U. Danesch, G. Posseckert, M. Beato, and G. Schutz, Cell 46:283-290, 1986) have suggested the existence of a glucocorticoid response element in the long terminal repeat of human immunodeficiency virus (HIV) type 1.  This study demonstrated a sequence-specific interaction of the glucocorticoid receptor DNA-binding domain with the previously predicted HIV glucocorticoid response element.  This interaction may be relevant to the steroid responsiveness of HIV (P. A. Furth, H. Westphal, and L. Hennighausen, AIDS Res. Hum. Retroviruses 6:553-560, 1990; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; J. Laurence, H. Cooke, and S. K. Sikder, Blood 75:696-703, 1990; D. A. Spandidos, V. Zoounpovilis, A. Kotsinas, C. Tsiripotis, and C. E. Sekeris, Anticancer Res. 10:1241-1246, 1990).
RP GHOSH, D (reprint author), NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894, USA.
NR 42
TC 47
Z9 47
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JAN
PY 1992
VL 66
IS 1
BP 586
EP 590
PG 5
WC Virology
SC Virology
GA GU971
UT WOS:A1992GU97100070
PM 1727502
ER

PT J
AU CUTLER, RG
   DAVIS, BJ
   INGRAM, DK
   ROTH, GS
AF CUTLER, RG
   DAVIS, BJ
   INGRAM, DK
   ROTH, GS
TI PLASMA-CONCENTRATIONS OF GLUCOSE, INSULIN, AND PERCENT GLYCOSYLATED
   HEMOGLOBIN ARE UNALTERED BY FOOD RESTRICTION IN RHESUS AND
   SQUIRREL-MONKEYS
SO JOURNALS OF GERONTOLOGY
LA English
DT Article
ID METABOLISM; PROTEINS; BLOOD; RATS
AB Plasma concentrations of glucose and percentage of glycosylated hemoglobin have been reported to be reduced in food-restricted rats when compared with ad libitum-fed controls (Masoro et al., 1989).  A similar experiment in primates, in which we also measured plasma insulin, is reported in this article.  Rhesus and squirrel monkeys were fed either ad libitum or 30% less than weight-matched controls for up to 36 months.  No significant age or diet effects on plasma concentration of glucose, insulin, or percentage glycosylated hemoglobin were observed, except that glucose concentration decreased with age in ad libitum-fed rhesus monkeys.  Moreover, no correlations between glucose levels and the percentage of glycosylated hemoglobin could be established within any group of animals.  These results suggest possible differences in glucose-related metabolism in ad libitum and food-restricted primates as compared to observations made in rats.
C1 NIH,FRANCIS SCOTT KEY MED CTR,GERONTOL RES CTR,NATHAN W SHOCK LABS,MOLEC PHYSIOL & GENET SECT,BALTIMORE,MD 21224.
   UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROBIOL & NEUROANAT,ROCHESTER,NY 14642.
NR 25
TC 22
Z9 23
U1 0
U2 0
PU GERONTOLOGICAL SOCIETY AMER
PI WASHINGTON
PA 1275 K STREET NW SUITE 350, WASHINGTON, DC 20005-4006
SN 0022-1422
J9 J GERONTOL
JI J. Gerontol.
PD JAN
PY 1992
VL 47
IS 1
BP B9
EP B12
PG 4
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA GY680
UT WOS:A1992GY68000007
PM 1730847
ER

PT J
AU KLINE, DW
   KLINE, TJB
   FOZARD, JL
   KOSNIK, W
   SCHIEBER, F
   SEKULER, R
AF KLINE, DW
   KLINE, TJB
   FOZARD, JL
   KOSNIK, W
   SCHIEBER, F
   SEKULER, R
TI VISION, AGING, AND DRIVING - THE PROBLEMS OF OLDER DRIVERS
SO JOURNALS OF GERONTOLOGY
LA English
DT Article
ID AGE; FIELD; PERCEPTION
AB Although there are well-recognized declines in visual functioning with age, their contribution to the problems of older persons on tasks in the natural environment, including driving, are largely unknown.  Adults ranging in age from 22-92 years were surveyed in regard to their visual difficulties when driving and performing everyday tasks.  The visual problems of drivers increased with age along five different visual dimensions:  unexpected vehicles, vehicle speed, dim displays, windshield problems, and sign reading.  Several of the age-related visual problems that were reported appear to be related to the types of automobile accidents more common among older drivers.  The study also replicated the findings from an earlier investigation of non-driving tasks that showed visual declines with age on five dimensions:  visual processing speed, light sensitivity, dynamic vision, near vision and visual search.  These findings indicate promising areas of research regarding the effects of visual aging on tasks in the natural environment.
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
   KRUG LIFE SCI,SAN ANTONIO,TX.
   OAKLAND UNIV,ROCHESTER,MI 48063.
   BRANDEIS UNIV,WALTHAM,MA 02254.
RP KLINE, DW (reprint author), UNIV CALGARY,DEPT PSYCHOL,2500 UNIV DR NW,CALGARY T2N 2N4,ALBERTA,CANADA.
RI Fozard, James Leonard/B-3660-2009
NR 42
TC 29
Z9 29
U1 0
U2 8
PU GERONTOLOGICAL SOCIETY AMER
PI WASHINGTON
PA 1275 K STREET NW SUITE 350, WASHINGTON, DC 20005-4006
SN 0022-1422
J9 J GERONTOL
JI J. Gerontol.
PD JAN
PY 1992
VL 47
IS 1
BP P27
EP P34
PG 8
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA GY680
UT WOS:A1992GY68000019
PM 1730855
ER

PT J
AU KOPP, JB
   BIANCO, P
   YOUNG, MF
   TERMINE, JD
   ROBEY, PG
AF KOPP, JB
   BIANCO, P
   YOUNG, MF
   TERMINE, JD
   ROBEY, PG
TI RENAL TUBULAR EPITHELIAL-CELLS EXPRESS OSTEONECTIN INVIVO AND INVITRO
SO KIDNEY INTERNATIONAL
LA English
DT Article
ID 44-KILODALTON BONE PHOSPHOPROTEIN; BINDING PROTEIN SPARC; MESSENGER-RNA;
   INSITU HYBRIDIZATION; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE;
   MOLECULAR-CLONING; I COLLAGEN; RAT BONE; OSTEOPONTIN
AB Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined.  In the present studies, we have demonstrated that immunoreactive osteonectin is present in the distal cortical tubule and medullary tubules of murine kidney.  We surveyed the renal epithelial cell lines LLC-PK1, MDCK, and OK for the expression of mRNA encoding osteonectin.  We found that osteonectin mRNA is expressed by LLC-PK1 and OK cells but not by MDCK cells, as well as by adult kidney from several species.  Calcitonin and vasopressin, agents which increase cAMP in these cells, were found to decrease steady-state osteonectin mRNA concentrations.  We found that LLC-PK1 cells produced osteonectin protein, that the protein was localized to intracellular granules, and that the protein bound hydroxyapatite in vitro.  Pulse-chase analysis revealed that osteonectin was secreted from the cell layer to the medium after a lag time of four to six hours and was secreted preferentially from the basolateral domain of the cell.  The preferential secretion of the calcium-binding protein osteonectin from the renal epithelial cell is consistent with several possible functions, including a structural extracellular matrix protein, a participant in transepithelial ion transport, and an inhibitor of extracellular calcification.
C1 UNIV ROME LA SAPIENZA,DEPT BIOPATOL,SEZ ANAT PATOL,I-00185 ROME,ITALY.
RP KOPP, JB (reprint author), NIDR,BONE RES BRANCH,BLDG 30,ROOM 430,BETHESDA,MD 20892, USA.
RI Robey, Pamela/H-1429-2011; 
OI Robey, Pamela/0000-0002-5316-5576; Kopp, Jeffrey/0000-0001-9052-186X
NR 49
TC 19
Z9 19
U1 0
U2 0
PU BLACKWELL SCIENCE INC
PI MALDEN
PA 350 MAIN ST, MALDEN, MA 02148
SN 0085-2538
J9 KIDNEY INT
JI Kidney Int.
PD JAN
PY 1992
VL 41
IS 1
BP 56
EP 64
DI 10.1038/ki.1992.8
PG 9
WC Urology & Nephrology
SC Urology & Nephrology
GA GX918
UT WOS:A1992GX91800008
PM 1317480
ER

PT J
AU ABRUZZO, LV
   JAFFE, ES
   COTELINGAM, JD
   WHANGPENG, J
   SANDER, CA
   MEDEIROS, LJ
AF ABRUZZO, LV
   JAFFE, ES
   COTELINGAM, JD
   WHANGPENG, J
   SANDER, CA
   MEDEIROS, LJ
TI T-CELL LYMPHOBLASTIC LYMPHOMA WITH EOSINOPHILIA ASSOCIATED WITH
   SUBSEQUENT MYELOID MALIGNANCY
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI, BETHESDA, MD 20892 USA.
   NATL NAVAL MED CTR, BETHESDA, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A74
EP A74
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600445
ER

PT J
AU BARTH, R
   MERINO, MJ
   BAKER, A
   YANG, J
   ROSENBERG, S
AF BARTH, R
   MERINO, MJ
   BAKER, A
   YANG, J
   ROSENBERG, S
TI VALUE OF TRUCUT-NEEDLE BIOPSY (TCN) IN THE DIAGNOSIS AND GRADING OF
   SOFT-TISSUE SARCOMAS
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A2
EP A2
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600017
ER

PT J
AU BHAGAT, S
   RAFFELD, M
   WEISS, L
   JAFFE, E
   MASON, D
   STETLERSTEVENSON, M
AF BHAGAT, S
   RAFFELD, M
   WEISS, L
   JAFFE, E
   MASON, D
   STETLERSTEVENSON, M
TI BCL-2 EXPRESSION IN HODGKINS-DISEASE AND ITS ASSOCIATION WITH THE
   T(14-18) TRANSLOCATION AND EBV
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NIH,PATHOL LAB,BETHESDA,MD 20892.
   CITY HOPE NATL MED CTR,DUARTE,CA 91010.
   JOHN RADCLIFFE HOSP,OXFORD OX3 9DU,ENGLAND.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A75
EP A75
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600454
ER

PT J
AU CAMPO, E
   MERINO, MJ
   MONTEAGUDO, C
   CHARONIS, A
   LLOMBARTBOSCH, A
   SOBEL, ME
AF CAMPO, E
   MERINO, MJ
   MONTEAGUDO, C
   CHARONIS, A
   LLOMBARTBOSCH, A
   SOBEL, ME
TI LAMININ RECEPTOR EXPRESSION AND BASEMENT-MEMBRANE LAMININ DISTRIBUTION
   IN ENDOCERVICAL ADENOCARCINOMAS
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   HOSP CLIN BARCELONA,BARCELONA,SPAIN.
   UNIV MINNESOTA,MINNEAPOLIS,MN 55455.
   UNIV VALENCIA,VALENCIA,SPAIN.
RI Monteagudo, Carlos/H-6555-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A62
EP A62
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600373
ER

PT J
AU CAMPO, E
   MIQUEL, R
   LEONE, A
   PALACIN, A
   JUAN, M
   VIVES, J
   STEEG, P
   YAGUE, J
   CARDESA, A
AF CAMPO, E
   MIQUEL, R
   LEONE, A
   PALACIN, A
   JUAN, M
   VIVES, J
   STEEG, P
   YAGUE, J
   CARDESA, A
TI NM23 SOMATIC ALLELIC DELETIONS IN HUMAN COLORECTAL CARCINOMAS
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 HOSP CLIN BARCELONA,BARCELONA,SPAIN.
   NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A40
EP A40
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600244
ER

PT J
AU FERNANDEZ, PL
   MERINO, MJ
   NOGALES, FF
   CHARONIS, A
   STETLERSTEVENSON, WG
   LIOTTA, L
AF FERNANDEZ, PL
   MERINO, MJ
   NOGALES, FF
   CHARONIS, A
   STETLERSTEVENSON, WG
   LIOTTA, L
TI THE ROLE OF EXTRACELLULAR-MATRIX AND ENZYMES IN PHYSIOLOGICAL INVASION
   AT THE PLACENTAL IMPLANTATION SITE
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   FAC MED GRANADA,GRANADA,SPAIN.
   UNIV MINNESOTA,MINNEAPOLIS,MN 55455.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A63
EP A63
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600383
ER

PT J
AU MEDEIROS, LJ
   JAFFE, ES
   CHEN, YY
   WEISS, LM
AF MEDEIROS, LJ
   JAFFE, ES
   CHEN, YY
   WEISS, LM
TI LOCALIZATION OF EPSTEIN-BARR VIRAL GENOMES IN ANGIOCENTRIC
   IMMUNOPROLIFERATIVE LESIONS
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   CITY HOPE NATL MED CTR,DUARTE,CA 91010.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A83
EP A83
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600502
ER

PT J
AU MEDEIROS, LJ
   ANDRADE, RE
   JAFFE, ES
   WEISS, LM
AF MEDEIROS, LJ
   ANDRADE, RE
   JAFFE, ES
   WEISS, LM
TI DETECTION AND LOCALIZATION OF EPSTEIN-BARR VIRAL GENOMES IN
   ANGIOIMMUNOBLASTIC LYMPHADENOPATHY (AILD) AND AILD-LIKE LYMPHOMA
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   CITY HOPE NATL MED CTR,DUARTE,CA 91010.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A83
EP A83
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600501
ER

PT J
AU MONTEAGUDO, C
   MERINO, MJ
   CASTRONOVO, V
   LLOMBARTBOSCH, A
   SOBEL, M
AF MONTEAGUDO, C
   MERINO, MJ
   CASTRONOVO, V
   LLOMBARTBOSCH, A
   SOBEL, M
TI LAMININ RECEPTOR (LR) EXPRESSION IS INCREASED IN BREAST-CANCER BUT NOT
   IN BENIGN BREAST-LESIONS - AN IMMUNOHISTOCHEMICAL STUDY
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
   UNIV VALENCIA,VALENCIA,SPAIN.
RI Monteagudo, Carlos/H-6555-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A16
EP A16
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600096
ER

PT J
AU NAVARRO, S
   PELLIN, A
   NOGUERA, R
   DIAZ, P
   TSOKOS, M
   TRICHE, T
   LLOMBARTBOSCH, A
AF NAVARRO, S
   PELLIN, A
   NOGUERA, R
   DIAZ, P
   TSOKOS, M
   TRICHE, T
   LLOMBARTBOSCH, A
TI EXPRESSION OF DBL PROTOONCOGENE IN CHILDHOOD TUMORS AND TUMOR-CELL LINES
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 UNIV VALENCIA,VALENCIA,SPAIN.
   NCI,BETHESDA,MD 20892.
   CHILDRENS HOSP,LOS ANGELES,CA 90027.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A110
EP A110
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600665
ER

PT J
AU NELSON, AM
   NSIANGANA, Z
   STLOUIS, M
   BROWN, C
   MVULA, M
   MBALA, B
   OLEARY, T
AF NELSON, AM
   NSIANGANA, Z
   STLOUIS, M
   BROWN, C
   MVULA, M
   MBALA, B
   OLEARY, T
TI CERVICAL INTRAEPITHELIAL NEOPLASIA IN ZAIRIAN WOMEN WITH HIV-1 AND HPV
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 AFIP,WASHINGTON,DC.
   MAMA YEMO HOSP,KINSHASA,ZAIRE.
   CTR DIS CONTROL,ATLANTA,GA 30333.
   NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A27
EP A27
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600166
ER

PT J
AU OHORI, NP
   YOUSEM, SA
   STETLERSTEVENSON, WG
   COLBY, TV
   SONMEZALPAN, E
AF OHORI, NP
   YOUSEM, SA
   STETLERSTEVENSON, WG
   COLBY, TV
   SONMEZALPAN, E
TI COMPARISON OF EXTRACELLULAR-MATRIX ANTIGENS IN SUBTYPES OF
   BRONCHIOLOALVEOLAR CARCINOMA AND CONVENTIONAL PULMONARY ADENOCARCINOMA -
   AN IMMUNOHISTOCHEMICAL STUDY
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 PRESBYTERIAN UNIV HOSP,PITTSBURGH,PA.
   NIH,BETHESDA,MD 20892.
   MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A116
EP A116
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600696
ER

PT J
AU POSTAN, M
   CORREA, R
   WENTHOLD, R
   FERRANS, VJ
   TARLETON, RL
AF POSTAN, M
   CORREA, R
   WENTHOLD, R
   FERRANS, VJ
   TARLETON, RL
TI CULTURES OF TRYPANOSOMA-CRUZI INFECTED-MOUSE HEART PRODUCE MAST-CELL
   GROWTH-INVITRO
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 UNIV GEORGIA,DEPT ZOOL,ATHENS,GA 30602.
   NHLBI,PATHOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A22
EP A22
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600135
ER

PT J
AU SANDER, CA
   MEDEIROS, LJ
   JAFFE, ES
AF SANDER, CA
   MEDEIROS, LJ
   JAFFE, ES
TI COMMON VARIABLE HYPOGAMMAGLOBULINEMIA (CVH) - AN ANALYSIS OF LYMPHOID
   LESIONS IN 12 PATIENTS
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A87
EP A87
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600523
ER

PT J
AU WEISENBURGER, D
   ZAHM, S
   BABBITT, P
   SAAL, R
   VAUGHT, J
   BLAIR, A
AF WEISENBURGER, D
   ZAHM, S
   BABBITT, P
   SAAL, R
   VAUGHT, J
   BLAIR, A
TI AN INCREASED RISK OF LYMPHOMA AND MULTIPLE-MYELOMA IN WOMEN IS
   ASSOCIATED WITH HAIR COLORING PRODUCT USE
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 UNIV NEBRASKA,MED CTR,MED CTR,OMAHA,NE 68105.
   NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP A89
EP A89
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600538
ER

PT J
AU BODNER, S
   KOSS, M
AF BODNER, S
   KOSS, M
TI P53 MUTATIONS IN EWINGS-SARCOMA
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 USN,MED ONCOL BRANCH,NCI,BETHESDA,MD 20814.
   ARMED FORCES INST PATHOL,DIV PULM,WASHINGTON,DC 20306.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP P2
EP P2
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600752
ER

PT J
AU HIJAZI, Y
   HOROWITZ, M
   AVILA, N
   TSOKOS, M
AF HIJAZI, Y
   HOROWITZ, M
   AVILA, N
   TSOKOS, M
TI EXTRAOSSEOUS EWINGS-SARCOMA - DOES IT EXIST
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP P5
EP P5
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600770
ER

PT J
AU HIJAZI, Y
   JEFFERSON, J
   TSOKOS, M
AF HIJAZI, Y
   JEFFERSON, J
   TSOKOS, M
TI COMPARISON OF KNOWN MUSCLE MARKERS IN RHABDOMYOSARCOMAS (RMS)
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
C1 NIH,PATHOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD JAN
PY 1992
VL 66
IS 1
BP P5
EP P5
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA HA276
UT WOS:A1992HA27600771
ER

PT J
AU LI, ZZ
   CODE, JE
   VANDEMERWE, WP
AF LI, ZZ
   CODE, JE
   VANDEMERWE, WP
TI ER-YAG LASER ABLATION OF ENAMEL AND DENTIN OF HUMAN TEETH -
   DETERMINATION OF ABLATION RATES AT VARIOUS FLUENCES AND PULSE REPETITION
   RATES
SO LASERS IN SURGERY AND MEDICINE
LA English
DT Article
DE ER-YAG LASER; HUMAN ENAMEL DENTIN ABLATION; PULSE REPETITION RATES
   2HZ/5HZ; SEM OF DENTIN ABLATION; THERMAL EFFECTS
ID HARD SUBSTANCES
AB A pulsed Er:YAG laser (2.94 mum) was used to determine ablation depths per pulse of laser energy at 2 Hz and 5 Hz in human teeth cross sections of enamel and dentin. Ablation depths per pulse at 2 Hz in enamel of intact human teeth were measured and compared to ablation depths per pulse determined in enamel cross sections at 2 Hz. Close correlation was observed for ablation depths per pulse of laser energy between teeth cross sections and intact teeth for enamel. Photographs of lased holes at 2 Hz and 5 Hz indicated minimal thermal effects in enamel at fluences below 80 J/cm2. Minimal thermal effects in dentin were noted below 74 J/cm2. Scanning Electron Microscopy (SEM) pictures of lased dentin showed an irregular serrated surface. Results of this study suggest that the Er:YAG laser can effectively ablate enamel and dentin with minimal thermal effects at 2 Hz and 5 Hz.
C1 UNIFORMED SERV UNIV HLTH SCI,CTR BIOMED INSTRUMENTAT,4301 JONES BRIDGE RD,BETHESDA,MD 20814.
   NIH,CTR CLIN,COMMISSIONED OFFICERS DENT CLIN,BETHESDA,MD 20892.
NR 9
TC 111
Z9 114
U1 2
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0196-8092
J9 LASER SURG MED
JI Lasers Surg. Med.
PY 1992
VL 12
IS 6
BP 625
EP 630
DI 10.1002/lsm.1900120610
PG 6
WC Dermatology; Surgery
SC Dermatology; Surgery
GA KA047
UT WOS:A1992KA04700009
PM 1453865
ER

PT J
AU FISCHER, D
   NUSSINOV, R
   WOLFSON, HJ
AF FISCHER, D
   NUSSINOV, R
   WOLFSON, HJ
TI 3-D SUBSTRUCTURE MATCHING IN PROTEIN MOLECULES
SO LECTURE NOTES IN COMPUTER SCIENCE
LA English
DT Article
ID EVOLUTION; SEQUENCE; GLOBINS
AB Pattern recognition in proteins has become of central importance in Molecular Biology. Proteins are macromolecules composed of an ordered sequence of amino acids, referred to also as residues. The sequence of residues in a protein is called its primary structure. The 3-D conformation of a protein is referred to as its tertiary structure. During the last decades thousands of protein sequences have been decoded. More recently the 3-D conformation of several hundreds of proteins have been resolved using X-ray crystallographic techniques.
   Todate, most work on 3-D structural protein comparison has been limited to the linear matching of the 3-D conformations of contiguous segments (allowing insertions and deletions) of the amino acid chains. Several techniques originally developed for string matching have been modified to perform 3-D structural comparison based on the sequential order of the structures.
   We present an application of pattern recognition techniques (in particular matching algorithms) to structural comparison of proteins. The problem we are faced with is to devise efficient techniques for routine scanning of structural databases, searching for recurrences of inexact structural motifs not necessarily composed of contiguous segments of the amino acid chain. The method uses the Geometric Hashing technique which was originally developed for model-based object recognition problems in Computer Vision. Given the three dimensional coordinate data of the structures to be compared, our method automatically identifies every region of structural similarity between the structures without prior knowledge of an initial alignment. Typical structure comparison problems are examined and the results of the new method are compared with the published results from previous methods. Examples of the application of the method to identify and search for non-linear 3-D motifs are included.
C1 NCI,FCRF,PRI DYNACOR,MATH BIOL LAB,BETHESDA,MD 20892.
   TEL AVIV UNIV,FAC MED,SACKLER INST MOLEC MED,IL-69978 TEL AVIV,ISRAEL.
   NYU,COURANT INST MATH SCI,ROBOT RES LAB,NEW YORK,NY 10012.
RP FISCHER, D (reprint author), TEL AVIV UNIV,RAYMOND & BEVERLY SACKLER FAC EXACT SCI,DEPT COMP SCI,IL-69978 TEL AVIV,ISRAEL.
RI Wolfson, Haim/A-1837-2011
NR 26
TC 12
Z9 12
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0302-9743
J9 LECT NOTES COMPUT SC
JI Lect. Notes Comput. Sci.
PY 1992
VL 644
BP 136
EP 150
PG 15
WC Computer Science, Theory & Methods
SC Computer Science
GA KQ205
UT WOS:A1992KQ20500012
ER

PT J
AU MILLER, BA
   BLAIR, A
AF MILLER, BA
   BLAIR, A
TI CANCER RISKS AMONG ARTISTS
SO LEONARDO
LA English
DT Article
ID BLADDER-CANCER; OCCUPATIONAL RISKS; MORTALITY; PAINTERS; INDUSTRY;
   EXPOSURE; MEN
RP MILLER, BA (reprint author), NATL CANCER INST, DIV CANCER PREVENTION CONTROL, BETHESDA, MD 20892 USA.
NR 36
TC 1
Z9 1
U1 0
U2 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0024-094X
EI 1530-9282
J9 LEONARDO
JI Leonardo
PY 1992
VL 25
IS 2
BP 169
EP 173
DI 10.2307/1575708
PG 5
WC Art
SC Art
GA HZ468
UT WOS:A1992HZ46800009
ER

PT J
AU BAUMGOLD, J
   KARTON, Y
   MALKA, N
   JACOBSON, KA
AF BAUMGOLD, J
   KARTON, Y
   MALKA, N
   JACOBSON, KA
TI HIGH-AFFINITY ACYLATING ANTAGONISTS FOR MUSCARINIC RECEPTORS
SO LIFE SCIENCES
LA English
DT Article
ID ACETYLCHOLINE-RECEPTOR; ALZHEIMERS-DISEASE; EXPRESSION; IDENTIFICATION;
   CLONING; GENES
AB The muscarinic antagonists pirenzepine and telenzepine were derivitized as alkylamino derivatives at a site on the molecules corresponding to a region of bulk tolerance in receptor binding.  The distal primary amino groups were coupled to the cross-linking reagent meta-phenylene diisothiocyanate, resulting in two isothiocyanate derivatives that were found to inhibit muscarinic receptors irreversibly and in a dose-dependent fashion.  Preincubation of rat forebrain membranes with an isothiocyanate derivative followed by radioligand binding using [H-3]N-methylscopolamine diminished the B(max) value, but did not affect the K(d) value.  The receptor binding site was not restored upon repeated washing, indicating that irreversible inhibition had occurred.  IC50 values for the irreversible inhibition at rat forebrain muscarinic receptors were 0.15 nM and 0.19 nM, for derivatives of pirenzepine and telenzepine, respectively.  The isothiocyanate derivative of pirenzepine was non-selective as an irreversible muscarinic inhibitor, and the corresponding derivative prepared from telenzepine was 5-fold selective for forebrain (mainly m1) vs. heart (m2) muscarinic receptors.
C1 NIDDKD,BIOORGAN CHEM LAB,BETHESDA,MD 20892.
   ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL.
RP BAUMGOLD, J (reprint author), GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,ROSS HALL,ROOM 662,WASHINGTON,DC 20037, USA.
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU Intramural NIH HHS [Z01 DK031115-24, Z99 DK999999]
NR 20
TC 5
Z9 5
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 5
BP 345
EP 351
DI 10.1016/0024-3205(92)90586-E
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JB140
UT WOS:A1992JB14000004
PM 1625525
ER

PT J
AU SCHINDLER, CW
   TELLA, SR
   GOLDBERG, SR
AF SCHINDLER, CW
   TELLA, SR
   GOLDBERG, SR
TI ADRENOCEPTOR MECHANISMS IN THE CARDIOVASCULAR EFFECTS OF COCAINE IN
   CONSCIOUS SQUIRREL-MONKEYS
SO LIFE SCIENCES
LA English
DT Article
ID CENTRAL-NERVOUS-SYSTEM; VASOCONSTRICTION; MANAGEMENT; RESPONSES;
   TOXICITY; BLOCKADE; DOGS; RATS
AB The purpose of the current experiment was to study the role of various adrenoceptor subtypes in the cardiovascular response to cocaine in conscious squirrel monkeys. A variety of adrenoceptor antagonists were administered i.v. prior to the administration of 0.3 mg/kg cocaine (i.v.). Cocaine alone produced an increase in both blood pressure and heart rate. The non-selective alpha adrenoceptor antagonist phentolamine produced a dose-dependent antagonism of the pressor effect of cocaine, as did the alpha-1 selective antagonist prazosin. The alpha-2 selective antagonist yohimbine had no effect on the pressor effect of cocaine. The non-selective beta antagonist propranolol enhanced the pressor effect of cocaine as did the beta-1 selective antagonist atenolol. However, the effect of atenolol was not dose-dependent. The beta-2 selective antagonist ICI 118,551 and labetalol, which blocks both alpha and beta adrenoceptors, did not alter the pressor effect of cocaine. Propranolol, atenolol, and labetalol all antagonized the tachycardiac effect of cocaine in a dose-dependent manner, while the beta-2 antagonist ICI 118,551 did not. Phentolamine, prazosin and yohimbine also reduced the tachycardiac effect of cocaine, although these effects were dose-dependent only for yohimbine, which also significantly elevated baseline heart rate. These results indicate that alpha-1 adrenoceptor mechanisms mediate the pressor effect of cocaine, while beta-1 adrenoceptor mechanisms are involved in the tachycardiac effect of cocaine in squirrel monkeys. Propranolol potentiated cocaine's pressor effect through beta-2 independent mechanisms. Thus, neither alpha-2 nor beta-2 adrenoceptor mechanisms appear to be involved in cocaine's cardiovascular effects.
C1 UNIV MARYLAND,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201.
   GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,WASHINGTON,DC 20007.
RP SCHINDLER, CW (reprint author), NIDA,ADDICT RES CTR,BEHAV PHARMACOL & GENT LAB,POB 5180,BALTIMORE,MD 21224, USA.
NR 25
TC 29
Z9 29
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 9
BP 653
EP 660
DI 10.1016/0024-3205(92)90238-K
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JE803
UT WOS:A1992JE80300003
PM 1354322
ER

PT J
AU KIMES, AS
   SMITH, WJ
   WINCHELL, CJ
   LONDON, ED
AF KIMES, AS
   SMITH, WJ
   WINCHELL, CJ
   LONDON, ED
TI EFFECTS OF MORPHINE ON THE PHENOTYPIC-EXPRESSION OF CELL-SURFACE MARKERS
   ON MURINE LYMPHOCYTES
SO LIFE SCIENCES
LA English
DT Article
ID MICE; ADDICTS; SILICA; BLOOD
AB There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lymphocytes and to helper and cytotoxic/suppressor T-lymphocyte subtypes. The effect of morphine, as measured by flow cytometry using monoclonal antibodies specific for antigens expressed by these cells, was dose-dependent The decrease in expression of antigens was apparent as early as 24 h after morphine pellet implantation and continued for 3 days. In addition, a time-dependent increase in the expression of these antigens was observed in placebo- and morphine-treated mice, suggesting that the pellets had a small antigenic effect. However, at all times studied, morphine-treated mice had fewer cells expressing the antigens than placebo-treated mice. Our results provide additional evidence that the use of opioids by IV drug abusers compromises their immune function.
C1 JOHNS HOPKINS MED INST,DEPT SURG,BALTIMORE,MD 21205.
RP KIMES, AS (reprint author), NIDA,ADDICT RES CTR,NEUROPHARMACOL LAB,POB 5180,BALTIMORE,MD 21224, USA.
NR 22
TC 19
Z9 19
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 11
BP 807
EP 815
DI 10.1016/0024-3205(92)90607-Q
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JH638
UT WOS:A1992JH63800002
PM 1387920
ER

PT J
AU GLOWA, JR
   WILLIAMS, AN
AF GLOWA, JR
   WILLIAMS, AN
TI EFFECTS OF PRIOR EXPOSURE TO COCAINE - INTERACTION OF REINFORCING AND
   SUPPRESSANT EFFECTS
SO LIFE SCIENCES
LA English
DT Article
ID D-AMPHETAMINE; SQUIRREL-MONKEYS; BEHAVIOR; SCHEDULES; INJECTION;
   HISTORY; RATS
AB Squirrel monkeys were trained to respond under second-order schedules of food presentation and then sequentially exposed to either a self-administration (SA) and then a conditioned taste aversion (CTA) procedure, or a CTA procedure and then a SA procedure. Initial exposure to stimuli associated with post-session delivery of cocaine (0.3 mg/kg) either maintained (SA) or suppressed (CTA) responding, respectively. In contrast, following exposure to CTA, SA procedures failed to maintain levels of responding comparable to those seen with initial exposure to SA. Following exposure to SA, the CTA procedure failed to suppress responding. Thus, prior exposure to either the reinforcing or suppressant effects of cocaine modified its subsequent behavioral effects, suggesting a unique role for behavioral history in the abuse potential of cocaine.
RP GLOWA, JR (reprint author), NIMH,CNE,BIOPSYCHOL UNIT,BETHESDA,MD 20892, USA.
NR 26
TC 5
Z9 5
U1 3
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 13
BP 987
EP 994
DI 10.1016/0024-3205(92)90496-C
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JJ777
UT WOS:A1992JJ77700001
PM 1522757
ER

PT J
AU CREVELING, CR
   PADGETT, WL
   MCNEAL, ET
   COHEN, LA
   KIRK, KL
AF CREVELING, CR
   PADGETT, WL
   MCNEAL, ET
   COHEN, LA
   KIRK, KL
TI INCORPORATION OF 2-FLUOROHISTIDINE IN MURINE PROTEIN INVIVO
SO LIFE SCIENCES
LA English
DT Article
AB The tissue distribution an time course of incorporation into acid insoluble (bound) and acid soluble (free) fractions of [H-3]2-fluorohistidine is compared to that of U[C-14]Histidine in mouse tissues in vivo. The cycloheximide-sensitive incorporation of 2-FHis is between 9 and 17 percent of that of His. Unlike [C-14]His a major fraction, approximately 90% at 72 hrs, of isotope derived from [H-3]2-FHis remains in tissues for a prolonged period in an acid soluble form. The excretion of isotope derived from [C-14]His (T1/2 = 5 hr) is more rapid than from [H-3]2-FHis (T1/2 = 11.4 hrs). 2-FHis, at doses from 100 to 250 mg/kg produce a reversible inhibition of growth in mice.
RP CREVELING, CR (reprint author), NIDDK,BIOORGAN CHEM LAB,8A-1A27,BETHESDA,MD 20892, USA.
NR 11
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 15
BP 1197
EP 1204
DI 10.1016/0024-3205(92)90356-T
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JL769
UT WOS:A1992JL76900003
PM 1528089
ER

PT J
AU KIM, SH
   CHO, KW
   HWANG, YH
   OH, SH
   SEUL, KH
   KOH, GY
   KIM, SJ
AF KIM, SH
   CHO, KW
   HWANG, YH
   OH, SH
   SEUL, KH
   KOH, GY
   KIM, SJ
TI OVARIAN ATRIAL-NATRIURETIC-PEPTIDE DURING THE RAT ESTROUS-CYCLE
SO LIFE SCIENCES
LA English
DT Article
ID MESSENGER-RNA SEQUENCE; PERFUSED RABBIT ATRIA; FOLLICULAR-FLUID;
   ARGININE VASOPRESSIN; RENIN; RADIOIMMUNOASSAY; RELEASE;
   IMMUNOHISTOCHEMISTRY; IDENTIFICATION; PROGESTERONE
AB The changes in ovarian levels of immunoreactive atrial natriuretic peptide (irANP) and arginine vasopressin (irAVP) were observed during the estrous cycle of rat. We also demonstrated the synthesis of ovarian ANP. In adult 4-day cycling rats, ovarian level of irANP was found  to be the highest on proestrus and was to be the lowest on diestrus. Ovarian irANP level inversely correlated with ovarian level of irAVP. On reverse-phase HPLC, two distinct peaks of ovarian irANP, high and low molecular weight forms, existed in the each stage of the estrous cycle. However, no significant changes in plasma and atrial concentrations of ANP were observed during the cycle. The rat ovary contained mRNA coding for ANP. These data showing the synchronized cyclic change of ovarian irANP and irAVP with the estrous cycle suggest that the ovary locally synthesizes ANP and ovarian ANP may play regulatory roles on the follicular fluid dynamics.
C1 NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892.
RP KIM, SH (reprint author), JEONBUG NATL UNIV,SCH MED,DEPT PHYSIOL,JEONJU 560182,SOUTH KOREA.
RI Koh, Gou Young /C-1615-2011
NR 37
TC 21
Z9 22
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 16
BP 1291
EP 1299
DI 10.1016/0024-3205(92)90019-L
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JM667
UT WOS:A1992JM66700008
PM 1406049
ER

PT J
AU SHARPE, LG
   JAFFE, JH
   KATZ, JL
AF SHARPE, LG
   JAFFE, JH
   KATZ, JL
TI CARBAMAZEPINE PRODUCES NONSPECIFIC EFFECTS ON COCAINE
   SELF-ADMINISTRATION IN RATS
SO LIFE SCIENCES
LA English
DT Note
ID SEIZURES
AB Anecdotal evidence in humans suggest that carbamazepine suppresses cocaine-induced rush and craving. Such claims are unsupported in controlled trials using a placebo control. In the present study, rats were trained to self-administer i.v. cocaine in daily 2-hr sessions in which every tenth lever press delivered 1 mg/kg cocaine. After responding was stable, they were injected before each session with the vehicle for 2 days followed by carbamazepine for 2 days. At a 7 mg/kg dose, carbamazepine was without effect, whereas 15 mg/kg suppressed responding for cocaine only on the second (day 4) day of carbamazepine treatment. With 4 consecutive days of treatment, carbamazepine (15 mg/kg) reduced cocaine-maintained responding slightly, but significantly.  In another group of animals trained to lever-press for food reinforcement, carbamazepine (15 mg/kg) also significantly decreased the rate of responding, suggesting that the suppression of responding was not specific to cocaine-reinforced behavior.
RP SHARPE, LG (reprint author), NIDA,ADDICT RES CTR,PRECLIN PHARMACOL BRANCH,PSYCHOBIOL LAB,BALTIMORE,MD 21224, USA.
NR 17
TC 6
Z9 6
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 51
IS 3
BP PL13
EP PL18
DI 10.1016/0024-3205(92)90081-Y
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HY845
UT WOS:A1992HY84500010
PM 1614282
ER

PT J
AU GLOWA, JR
   INSEL, TR
AF GLOWA, JR
   INSEL, TR
TI EFFECTS OF CHLORDIAZEPOXIDE AND BETA-CARBOLINE 3-CARBOXYLIC ACID
   ETHYL-ESTER ON NON-SUPPRESSED AND MINIMALLY-SUPPRESSED RESPONDING IN THE
   SQUIRREL-MONKEY
SO LIFE SCIENCES
LA English
DT Article
ID BENZODIAZEPINE RECEPTOR; ANXIOGENIC PROPERTIES; EXPERIMENTAL ANXIETY;
   INTRINSIC ACTIONS; RO 15-1788; FG 7142; ANTAGONISTS; FG-7142; RATS; CCE
AB Lever-pressing of squirrel monkeys was maintained under a multiple fixed-interval (FI) 5-min schedule of food presentation. In one component, responding was suppressed to various degrees by the presentation of electric shock following each 30th response. When responding was either substantially or minimally suppressed, intermediate doses of chlordiazepoxide (CDAP, 1-30 mg/kg) increased both suppressed and non-suppressed responding. Beta-carboline 3-carboxylic acid ethyl ester (beta-CCE, 0.1-3 mg/kg) had little effect at low to intermediate doses (0.1-0.3 mg/kg) and decreased both minimally-suppressed and non-suppressed responding to a comparable extent at higher doses. Repeated daily dosing with beta-CCE (up to 10 mg/kg) resulted in rapid tolerance to its rate-decreasing effects. As agonists do not typically exhibit rapid tolerance for anxiolytic efficacy, the current results suggest that some behavioral effects of inverse agonists may not be strictly opposite those of benzodiazepines.
C1 NIMH,LCS,COMPARAT STUDIES BRAIN & BEHAV SECT,BETHESDA,MD 20892.
RP GLOWA, JR (reprint author), CNE,BIOPSYCHOL UNIT,BETHESDA,MD 20892, USA.
NR 38
TC 1
Z9 1
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 1
BP 7
EP 14
DI 10.1016/0024-3205(92)90191-Q
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GT537
UT WOS:A1992GT53700002
PM 1728726
ER

PT J
AU HSIAO, JK
   MANJI, HK
   CHEN, G
   BITRAN, JA
   RISBY, ED
   POTTER, WZ
AF HSIAO, JK
   MANJI, HK
   CHEN, G
   BITRAN, JA
   RISBY, ED
   POTTER, WZ
TI LITHIUM ADMINISTRATION MODULATES PLATELET GI IN HUMANS
SO LIFE SCIENCES
LA English
DT Article
ID ADENYLATE-CYCLASE ACTIVITY; INOSITOL PHOSPHOLIPID HYDROLYSIS; MESSENGER
   SIGNAL AMPLIFICATION; BINDING REGULATORY COMPONENT; ISLET-ACTIVATING
   PROTEIN; CYCLIC-AMP ACCUMULATION; RAT CEREBRAL-CORTEX; PERTUSSIS TOXIN;
   HORMONAL INHIBITION; GTP-BINDING
AB Platelet G proteins were assessed in 7 normal volunteers before and after 14 days of lithium administration at therapeutic plasma levels.  Cholera and pertussis toxin catalyzed ADP-ribosylation of platelet membrane proteins were measured by SDS-PAGE.  Immunoblotting with specific antibodies was used to measure platelet membrane alpha-i content.  There was a statistically significant 37% increase in pertussis toxin mediated ADP-ribosylation of a 40,000 Mr protein in platelet membranes after lithium administration, but cholera toxin mediated ADP-ribosylation of a 45,000 Mr protein and alpha-i immunoblotting were unchanged by lithium.  Increased pertussis toxin stimulated ADP-ribosylation in the absence of changes in alpha-i content could be explained by a shift in platelet G(i) in favor of its undissociated, inactive form.  This would be consistent with increased platelet adenylyl cyclase activity found in these same subjects after lithium.
RP HSIAO, JK (reprint author), NIMH,EXPTL THERAPEUT BRANCH,CLIN PHARMACOL SECT,BLDG 10,ROOM 2D46,BETHESDA,MD 20892, USA.
RI Chen, Guang/A-2570-2017
NR 52
TC 37
Z9 37
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 3
BP 227
EP 233
DI 10.1016/0024-3205(92)90276-U
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GV615
UT WOS:A1992GV61500009
PM 1731175
ER

PT J
AU SEI, Y
   MCINTYRE, T
   SKOLNICK, P
   ARORA, PK
AF SEI, Y
   MCINTYRE, T
   SKOLNICK, P
   ARORA, PK
TI ETHANOL INHIBITS MITOGEN-INDUCED CALCIUM MOBILIZATION IN MOUSE
   SPLENOCYTES
SO LIFE SCIENCES
LA English
DT Article
ID FLUORESCENT INDICATORS; ALCOHOL; LYMPHOCYTES; INTOXICATION; CANCER;
   SITES
AB Ethanol inhibited the mitogen-induced initial increase in cytoplasmic free-calcium [Ca2+]i in mouse splenocytes. This effect was concentration-dependent, reversible, and observed at pharmacologically relevant concentrations (24-166mM). Other short-chain alcohols such as propanol, butanol, and pentanol also inhibited this mitogen-induced increase in [Ca2+]i. The potencies of these alcohols to produce this effect were highly correlated (r = -0.98, p < 0.001) with their membrane/buffer partition coefficients. Analysis of mouse splenocyte subpopulations demonstrated that this effect was manifest in both B and T lymphocytes. Within T lymphocyte subpopulations, both CD4+ and CD8+ T cells were affected. These results suggest that the inhibition of [Ca2+]i increase may be an early event mediating ethanol-induced immunosuppression and that this may be a predisposing factor to infection and malignancies associated with alcoholism.
RP SEI, Y (reprint author), NIDDKD,NEUROSCI LAB,BETHESDA,MD 20892, USA.
NR 23
TC 11
Z9 11
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 6
BP 419
EP 426
DI 10.1016/0024-3205(92)90376-Z
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GZ175
UT WOS:A1992GZ17500003
PM 1346466
ER

PT J
AU KATZ, JL
   TERRY, P
   WITKIN, JM
AF KATZ, JL
   TERRY, P
   WITKIN, JM
TI COMPARATIVE BEHAVIORAL PHARMACOLOGY AND TOXICOLOGY OF COCAINE AND ITS
   ETHANOL-DERIVED METABOLITE, COCAINE ETHYL-ESTER (COCAETHYLENE)
SO LIFE SCIENCES
LA English
DT Article
ID ALCOHOL
AB The present study compared the behavioral and toxic effects of cocaine and its ethanol derived metabolite, cocaine ethyl-ester (cocaethylene).  Both drugs produced qualitatively similar psychomotor stimulant effects.  Cocaine and cocaethylene increased locomotor activity in mice, with cocaine approximately four times more potent than cocaethylene.  The durations of action of ED75 doses of each of the drugs were comparable.  Each of the drugs also produced stimulation of operant responding in rats.  In rats and squirrel monkeys trained to discriminate cocaine injections from saline, cocaine was approximately three to five times more potent than cocaethylene in producing these cocaine-like interoceptive effects.  In contrast to the behavioral effects, cocaine and cocaethylene were equipotent in producing convulsions, and cocaethylene was more potent than cocaine in producing lethality.  These results suggest that the conversion of cocaine to cocaethylene with simultaneous cocaine and alcohol use may produce an increased risk of toxicity due to a decrease in the potency of cocaethylene in producing psychomotor stimulant effects, and its increased potency in producing toxicity.
RP KATZ, JL (reprint author), NIDA,ADDICT RES CTR,PRECLIN PHARMACOL BRANCH,PSYCHOBIOL LAB,BALTIMORE,MD 21224, USA.
OI Katz, Jonathan/0000-0002-1068-1159
NR 27
TC 114
Z9 114
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 18
BP 1351
EP 1361
DI 10.1016/0024-3205(92)90286-X
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HK531
UT WOS:A1992HK53100008
PM 1532847
ER

PT J
AU KASPER, E
   VENTURA, C
   ZIMAN, BD
   LAKATTA, EG
   WEISMAN, H
   CAPOGROSSI, MC
AF KASPER, E
   VENTURA, C
   ZIMAN, BD
   LAKATTA, EG
   WEISMAN, H
   CAPOGROSSI, MC
TI EFFECT OF U-50,488H ON THE CONTRACTILE RESPONSE OF CARDIOMYOPATHIC
   HAMSTER VENTRICULAR MYOCYTES
SO LIFE SCIENCES
LA English
DT Article
ID SYRIAN-HAMSTER; CARDIAC MYOCYTES; RESPONSIVENESS; NORADRENALINE;
   ADRENOCEPTORS; RECEPTORS
AB We examined the effects of a selective kappa-opioid receptor agonist (U-50,488H) on the contractile properties of single ventricular myocytes from 127 day old control (F1B) and cardiomyopathic (BIO 14.6) hamsters. Myocytes in bicarbonate buffered solution with 1.5 mM [Ca2+] were electrically stimulated with field electrodes in the bath. Length changes were monitored via myocyte edge tracking.  Twitch amplitude and the velocity of cell shortening were less in the cardiomyopathic hamster myocytes than in age-matched hamsters (P less-than-or-equal-to 0.05). There was a concentration-dependent effect of U-50,488H (0.1-20-mu-M) to decrease twitch amplitude and shortening velocity in both control and cardiomyopathic myocytes (P less-than-or-equal-to 0.001). In cells loaded with the Ca2+ indicator indo-1 the negative inotropic action of UD-50,488H was associated with a decreased indo-1 fluorescence transient amplitude. There was no difference in the negative inotropic effect of UD-50,488H on control and cardiomyopathic cells. Thus, the CM hamster does not demonstrate a different contractile response to U-50,488H.
C1 NIA,GERONTOL RES CTR,CARDIOVASC SCI LAB,4940 EASTERN AVE,BALTIMORE,MD 21224.
   JOHNS HOPKINS MED INST,DIV CARDIOL,BALTIMORE,MD 21205.
NR 15
TC 16
Z9 16
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 26
BP 2029
EP 2035
DI 10.1016/0024-3205(92)90568-A
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HX037
UT WOS:A1992HX03700001
PM 1608286
ER

PT J
AU GILAD, GM
   GILAD, VH
   WYATT, RJ
   CASERO, RA
AF GILAD, GM
   GILAD, VH
   WYATT, RJ
   CASERO, RA
TI CHRONIC LITHIUM TREATMENT PREVENTS THE DEXAMETHASONE-INDUCED INCREASE OF
   BRAIN POLYAMINE METABOLIZING ENZYMES
SO LIFE SCIENCES
LA English
DT Note
ID ORNITHINE DECARBOXYLASE INDUCTION; SPERMIDINE; RATS; INHIBITION;
   TURNOVER; ISCHEMIA
AB The paper describes the effects of various regimens of lithium chloride treatment on dexamethasone-induced increases in brain polyamine metabolizing enzymes.  In contrast to peripheral tissues where acute lithium treatment suppresses the increase in ornithine decarboxylase activity, in the brain only chronic treatment was effective in preventing this increase and also the increases in the activities of S-adenosylmethionine decarboxylase and spermidine/spermine N1-acetyltransferase.  This findings indicate a novel brain target for lithium's action and in turn provide new avenues for exploring polyamine function in the brain.
C1 JOHNS HOPKINS UNIV,SCH MED,JOHNS HOPKINS ONCOL CTR,BALTIMORE,MD 21231.
RP GILAD, GM (reprint author), ST ELIZABETH HOSP,NIMH,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032, USA.
NR 30
TC 21
Z9 21
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 18
BP PL149
EP PL154
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HK531
UT WOS:A1992HK53100011
ER

PT J
AU SCHINDLER, CW
   MARLEY, RJ
   GOLDBERG, SR
AF SCHINDLER, CW
   MARLEY, RJ
   GOLDBERG, SR
TI ENHANCED SENSITIVITY TO NALTREXONE IS ASSOCIATED WITH AN UP-REGULATION
   IN GABA RECEPTOR FUNCTION
SO LIFE SCIENCES
LA English
DT Note
ID SQUIRREL-MONKEYS; NALOXONE; BINDING; INVOLVEMENT; BRAIN
AB Rats were made sensitive to the effects of the opioid antagonist naltrexone by treating them once weekly with cumulative doses of the drug (1, 3, 10, 30 and 100 mg/kg).  Sensitization was monitored by measuring salivation following naltrexone administration.  During the first week of treatment, no salivation was noted following any dose of naltrexone.  Over a period of 8 weeks, however, increasing amounts of salivation were noted, with the most salivation occurring at the higher doses.  Animals treated for 8 weeks with saline never salivated following injections.  Following the development of sensitivity to naltrexone, the rats were sacrificed and their brains were assayed for GABA receptor function.  GABA-stimulated chloride uptake, a measure of GABA receptor function, was unchanged in the cortex, but was increased in the cerebellum.  These results suggest that the effects of naltrexone on cerebellar GABA receptors may be involved in the development of enhanced sensitivity to opioid antagonists.
C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201.
RP SCHINDLER, CW (reprint author), NIDA,ADDICT RES CTR,PRECLIN PHARMACOL BRANCH,BEHAV PHARMACOL & GENET LAB,POB 5180,BALTIMORE,MD 21224, USA.
NR 19
TC 9
Z9 9
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PY 1992
VL 50
IS 4
BP PL1
EP PL6
DI 10.1016/0024-3205(92)90341-L
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GW862
UT WOS:A1992GW86200011
PM 1310130
ER

PT J
AU PEKAR, J
   MOONEN, CTW
   VANZIJL, PCM
AF PEKAR, J
   MOONEN, CTW
   VANZIJL, PCM
TI ON THE PRECISION OF DIFFUSION PERFUSION IMAGING BY GRADIENT
   SENSITIZATION
SO MAGNETIC RESONANCE IN MEDICINE
LA English
DT Article
C1 DEPT PHARMACOL,ROCKVILLE,MD 20850.
RP PEKAR, J (reprint author), NIH,NATL CTR RES RESOURCES,BIOMED ENG & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892, USA.
RI van Zijl, Peter/B-8680-2008; Moonen, Chrit/K-4434-2016
OI Moonen, Chrit/0000-0001-5593-3121
NR 10
TC 76
Z9 77
U1 0
U2 2
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0740-3194
J9 MAGNET RESON MED
JI Magn.Reson.Med.
PD JAN
PY 1992
VL 23
IS 1
BP 122
EP 129
DI 10.1002/mrm.1910230113
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA HA599
UT WOS:A1992HA59900012
PM 1734174
ER

PT J
AU RAMESH, V
   CHENG, SV
   KOZAK, CA
   HERRON, BJ
   SHIH, VE
   TAYLOR, BA
   GUSELLA, JF
AF RAMESH, V
   CHENG, SV
   KOZAK, CA
   HERRON, BJ
   SHIH, VE
   TAYLOR, BA
   GUSELLA, JF
TI MAPPING OF ORNITHINE AMINOTRANSFERASE GENE-SEQUENCES TO MOUSE
   CHROMOSOME-7, CHROMOSOME-X, AND CHROMOSOME-3
SO MAMMALIAN GENOME
LA English
DT Article
ID GYRATE ATROPHY; STRUCTURAL GENE; OAT LOCUS; RETINA; LOCALIZATION;
   DISEASE; CLONING; MICE
AB Ornithine aminotransferase (OAT), a mitochondrial matrix enzyme, is deficient in patients with gyrate atrophy of the choroid and retina. In human, the OAT structural gene maps to Chromosome (Chr) 10q26 and several OAT-related sequences, some of which are known to be processed pseudogenes, which map to Xp11.3-11.21. Here, we report chromosomal localization in the mouse of the OAT gene and related sequences. Genomic DNA blot analysis of a well-characterized panel of Chinese hamster x mouse somatic cell hybrids using a human OAT probe revealed two murine loci, one on mouse Chr 7 and the other on Chr X. In addition, segregation of restriction fragment length polymorphisms (RFLPs) detected by the OAT probe in recombinant inbred (RI) strains detected a third locus on Chr 3 and positioned the X locus near Cf-8 and Rsvp. Progeny of an intersubspecific back-cross were used to map the Chr 7 locus between Tyr and Int-2, near Cyp2e-1.
C1 MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02129.
   MASSACHUSETTS GEN HOSP,NEUROL SERV,AMINO ACID DISORDER LAB,BOSTON,MA 02129.
   NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892.
   JACKSON LAB,BAR HARBOR,ME 04609.
FU NEI NIH HHS [EY05633]; NHGRI NIH HHS [HG00169]; NINDS NIH HHS [NS05096]
NR 32
TC 10
Z9 10
U1 0
U2 2
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 1
BP 17
EP 22
DI 10.1007/BF00355836
PG 6
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT426
UT WOS:A1992JT42600004
PM 1349842
ER

PT J
AU DANCIGER, M
   KOZAK, CA
   ADAMSON, MC
   FARBER, DB
AF DANCIGER, M
   KOZAK, CA
   ADAMSON, MC
   FARBER, DB
TI CHROMOSOMAL LOCALIZATION OF THE MURINE GENES FOR THE ALPHA-SUBUNIT AND
   BETA-SUBUNIT OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE-II
SO MAMMALIAN GENOME
LA English
DT Note
ID RETINAL CALMODULIN KINASE; DEGENERATION SLOW RDS;
   CGMP-PHOSPHODIESTERASE; MOLECULAR-CLONING; MOUSE; BRAIN; CDNA;
   SEQUENCES; PHOSPHORYLATION; IDENTIFICATION
C1 UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,LOS ANGELES,CA 90024.
   LOYOLA MARYMOUNT UNIV,LOS ANGELES,CA 90045.
   NIAID,BETHESDA,MD 20892.
FU NEI NIH HHS [EY 08285, EY 00331]
NR 34
TC 10
Z9 10
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 2
BP 122
EP 125
DI 10.1007/BF00431257
PG 4
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT430
UT WOS:A1992JT43000011
PM 1319776
ER

PT J
AU GOUGH, NM
   LIPKOWITZ, S
   KIRSCH, IR
   BEGLEY, CG
AF GOUGH, NM
   LIPKOWITZ, S
   KIRSCH, IR
   BEGLEY, CG
TI LOCALIZATION OF MURINE HLH GENE NSCL TO CHROMOSOME-1 BY USE OF
   RECOMBINANT INBRED STRAINS
SO MAMMALIAN GENOME
LA English
DT Note
ID DNA-BINDING; PROTEINS; MOTIF; MYC
C1 NCI,NAVY MED ONCOL BRANCH,BETHESDA,MD 20814.
   ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA.
   ROYAL MELBOURNE HOSP,DEPT DIAGNOST HAEMATOL,PARKVILLE,VIC 3050,AUSTRALIA.
NR 9
TC 5
Z9 5
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 3
BP 182
EP 183
DI 10.1007/BF00352465
PG 2
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT432
UT WOS:A1992JT43200009
PM 1617226
ER

PT J
AU MODI, WS
AF MODI, WS
TI NUCLEOTIDE-SEQUENCE AND GENOMIC ORGANIZATION OF A TANDEM SATELLITE ARRAY
   FROM THE ROCK VOLE MICROTUS-CHROTORRHINUS (RODENTIA)
SO MAMMALIAN GENOME
LA English
DT Article
ID BASE SEQUENCE; HUMAN DNA; EVOLUTION; DIPODOMYS
AB A tandem satellite array (herein named MSAT-160) has been isolated and characterized from the rodent Microtus chrotorrhinus. Sequence data from 15 partial or complete monomers revealed a repeat unit length of 160 bp. This unit length was apparently derived from two shorter sub-motifs, one a tetramer (GAAA), the other a hexamer (CTTTCT), through polymerase slippage and mutation. Collectively, perfect or imperfect variants of these two motifs comprise nearly 60% of the component. Southern blot analyses of genomic DNA digested with 14 different restriction endonucleases indicated that most enzymes yielded either classical type A or type B restriction patterns, while RsaI yielded a pattern that combined features of both the A and B types, and BamHI appeared to lack sites altogether in MSAT-160. An examination of restriction patterns from 16 individuals with three enzymes failed to identify intraspecific variation, while a related study compared 11 species and documented interspecific distinctiveness (Modi, submitted). Fluorescence in situ hybridization indicated that the satellite DNA was located at the centromeres of several autosomes and at sex chromosome heterochromatin (GenBank accession No. M86843).
RP MODI, WS (reprint author), NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,BIOL CARCINOGENESIS DEV PROGRAM,FREDERICK,MD 21702, USA.
FU NCI NIH HHS [N0I-CO-74102]
NR 34
TC 33
Z9 33
U1 0
U2 1
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 4
BP 226
EP 232
DI 10.1007/BF00355723
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JV423
UT WOS:A1992JV42300007
PM 1611217
ER

PT J
AU MIETZ, JA
   KUFF, EL
AF MIETZ, JA
   KUFF, EL
TI INTRACISTERNAL A-PARTICLE-SPECIFIC OLIGONUCLEOTIDES PROVIDE MULTILOCUS
   PROBES FOR GENETIC-LINKAGE STUDIES IN THE MOUSE
SO MAMMALIAN GENOME
LA English
DT Article
ID MAMMARY-TUMOR VIRUSES; TETRAMETHYLAMMONIUM CHLORIDE; DNA;
   IDENTIFICATION; HYBRIDIZATION; SEQUENCES; LIBRARIES; MUTATION; PATTERNS;
   GENOME
AB Oligonucleotide probes representing distinct intracisternal A-particle (IAP) subfamilies were derived from the long terminal repeats (LTRs) of transcriptionally active IAP genes in normal mouse cells. These probes were used to examine the distribution of IAP proviral elements in the genomic DNA of several inbred mouse strains. Each oligonucleotide probe identified multiple polymorphisms between the different strains. The distribution of polymorphic restriction fragments among the CXB set of recombinant inbred (RI) strains demonstrates the feasibility of using these probes for chromosome mapping. These and other subset-specific IAP probes can provide a useful series of multilocus markers for genomic mapping and genetic analysis in the mouse.
C1 NCI,BIOCHEM LAB,BETHESDA,MD 20892.
NR 22
TC 11
Z9 11
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 8
BP 447
EP 451
DI 10.1007/BF00356154
PG 5
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT436
UT WOS:A1992JT43600003
PM 1643306
ER

PT J
AU JOHNSON, KR
   COOK, SA
   BUSTIN, M
   DAVISSON, MT
AF JOHNSON, KR
   COOK, SA
   BUSTIN, M
   DAVISSON, MT
TI GENETIC-MAPPING OF THE MURINE GENE AND 14 RELATED SEQUENCES ENCODING
   CHROMOSOMAL PROTEIN HMG-14
SO MAMMALIAN GENOME
LA English
DT Article
ID LEUKEMIA-VIRUS; MULTIGENE FAMILY; SYNDROME REGION; CDNA SEQUENCE; MOUSE;
   PROVIRUSES; IDENTIFICATION; PSEUDOGENES; LINKAGE; MAP
AB The high-mobility-group chromosomal protein HMG-14 preferentially binds to nucleosomal core particles of mammalian chromatin and may modulate the chromatin configuration of transcriptionally active genes. The human gene for HMG-14 has been localized to the Down syndrome region of Chromosome (Chr) 21 and may be involved in the etiology of this syndrome. Here we show, by means of genetic linkage analysis of interspecific and intersubspecific backcross mice, that the murine functional gene, Hmg14, is located on the distal end of mouse Chr 16, a region known to have conserved synteny with human Chr 21. In addition to the functional gene for HMG-14, both human and mouse genomes contain many related sequences that are probably processed pseudogenes. Here we map the locations of 14 Hmg14-related sequences in two mouse genomes. The 14 mapped loci are widely dispersed on ten chromosomes (Chrs 3, 5, 7, 9, 11, 12, 16, 17, 19, and X) and can be detected efficiently with a single cDNA probe. Thus, the Hmg14 multigene family is well suited to serve as genetic markers for other linkage studies in mice.
C1 NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892.
RP JOHNSON, KR (reprint author), JACKSON LAB,600 MAIN ST,BAR HARBOR,ME 04609, USA.
RI Bustin, Michael/G-6155-2015
FU NCI NIH HHS [CA34196]; NCRR NIH HHS [RR01183]; NIGMS NIH HHS [GM46697]
NR 37
TC 27
Z9 27
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 11
BP 625
EP 632
DI 10.1007/BF00352479
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JX885
UT WOS:A1992JX88500003
PM 1360278
ER

PT J
AU KRALL, M
   RUFF, N
   ZIMMERMAN, K
   AGGARWAL, A
   DOSIK, J
   REEVES, R
   MOCK, BA
AF KRALL, M
   RUFF, N
   ZIMMERMAN, K
   AGGARWAL, A
   DOSIK, J
   REEVES, R
   MOCK, BA
TI ISOLATION AND MAPPING OF 4 NEW DNA MARKERS FROM MOUSE CHROMOSOME-4
SO MAMMALIAN GENOME
LA English
DT Note
ID GENES
C1 NCI,GENET LAB,BLDG 37,ROOM 2B-08,BETHESDA,MD 20892.
   JOHNS HOPKINS UNIV,SCH MED,DEV GENET LAB,BALTIMORE,MD 21205.
FU NCI NIH HHS [N01-CB-21075]
NR 8
TC 6
Z9 6
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
IS 11
BP 653
EP 655
DI 10.1007/BF00352484
PG 3
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JX885
UT WOS:A1992JX88500008
PM 1360280
ER

PT J
AU ABBOTT, CM
   BLANK, R
   EPPIG, JT
   FRIEDMAN, JM
   HUPPI, KE
   JACKSON, I
   MOCK, BA
   STOYE, J
   WISEMAN, R
AF ABBOTT, CM
   BLANK, R
   EPPIG, JT
   FRIEDMAN, JM
   HUPPI, KE
   JACKSON, I
   MOCK, BA
   STOYE, J
   WISEMAN, R
TI MOUSE CHROMOSOME-4
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID RECOMBINANT-INBRED STRAINS; MURINE LEUKEMIA VIRUSES; GENETIC-ANALYSIS;
   MOLECULAR-CLONING; LINKAGE ANALYSIS; SURFACE-ANTIGEN; MICE; LOCUS;
   LOCALIZATION; MAP
C1 ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021.
   JACKSON LAB,BAR HARBOR,ME 04609.
   NCI,GENET LAB,BETHESDA,MD 20892.
   WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND.
   NATL INST MED RES,LONDON NW7 1AA,ENGLAND.
   NIEHS,RES TRIANGLE PK,NC 27709.
RP ABBOTT, CM (reprint author), UNIV LONDON UNIV COLL,DEPT GENET & BIOCHEM,WOLFSON HOUSE,4 STEPHENSON WAY,LONDON NW1 2HE,ENGLAND.
RI Abbott, Catherine/C-7306-2013
FU NHGRI NIH HHS [HG00316]
NR 92
TC 28
Z9 28
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S55
EP S64
DI 10.1007/BF00648422
PG 10
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900004
PM 1498443
ER

PT J
AU CECI, JD
   LUSIS, AJ
AF CECI, JD
   LUSIS, AJ
TI MOUSE CHROMOSOME-8
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID TISSUE-SPECIFIC EXPRESSION; MURINE LEUKEMIA VIRUSES; FINGER PROTEIN
   GENE; MUS-MUSCULUS; LINKAGE MAP; ADENINE PHOSPHORIBOSYLTRANSFERASE;
   DEVELOPMENTAL REGULATION; ANGIOTENSINOGEN GENE; STRUCTURAL GENE; HOUSE
   MOUSE
C1 UNIV CALIF LOS ANGELES,DEPT MED,LOS ANGELES,CA 90024.
   UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024.
RP CECI, JD (reprint author), NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702, USA.
FU NCI NIH HHS [N01-CO-74101]; NHLBI NIH HHS [HL42488]; NIDDK NIH HHS
   [DK44092]
NR 145
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S121
EP S135
DI 10.1007/BF00648426
PG 15
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900008
PM 1498427
ER

PT J
AU ELLIOTT, RW
   MOORE, KJ
AF ELLIOTT, RW
   MOORE, KJ
TI MOUSE CHROMOSOME-6
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID CELL DIFFERENTIATION ANTIGEN; CHAIN GENETIC-MARKERS; MAMMARY-TUMOR
   VIRUSES; CYSTIC-FIBROSIS LOCUS; CROSSOVER POPULATIONS SUGGEST;
   PCR-ANALYZED MICROSATELLITES; RECOMBINANT INBRED STRAINS; KAPPA-DELETING
   ELEMENT; CONSTANT REGION GENES; GAMMA-ACTIN GENE
C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702.
RP ELLIOTT, RW (reprint author), ROSWELL PK CANC INST,DEPT MOLEC & CELLULAR BIOL,BUFFALO,NY 14263, USA.
FU NCI NIH HHS [N01-CO-74101]; NHGRI NIH HHS [HG00342]
NR 282
TC 13
Z9 13
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S81
EP S103
DI 10.1007/BF00648424
PG 23
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900006
PM 1498445
ER

PT J
AU JUSTICE, MJ
   STEPHENSON, DA
AF JUSTICE, MJ
   STEPHENSON, DA
TI MOUSE CHROMOSOME-13
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID RECOMBINANT INBRED STRAINS; GROWTH-HORMONE; DIHYDROFOLATE-REDUCTASE;
   T-CELLS; CHORIONIC SOMATOMAMMOTROPIN; GENE FAMILY; GAMMA-CHAIN; LONG
   ARM; BEIGE BG; LOCI
C1 ROSWELL PK CANC INST,BUFFALO,NY 14263.
RP JUSTICE, MJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702, USA.
FU NCI NIH HHS [N01-CO-74101, 5F32CA08853-03]
NR 101
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S195
EP S205
DI 10.1007/BF00648431
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900013
PM 1498432
ER

PT J
AU KOZAK, CA
   STEPHENSON, DA
AF KOZAK, CA
   STEPHENSON, DA
TI MOUSE CHROMOSOME-5
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID MURINE LEUKEMIA-VIRUS; RECOMBINANT INBRED STRAINS; BUTYRYL
   COA-DEHYDROGENASE; ACTIVITY GENE MGSA; NUCLEAR FACTOR-I; W-LOCUS;
   RETINAL DEGENERATION; BETA-SUBUNIT; RD MOUSE; INTERSPECIFIC BACKCROSS
C1 ROSWELL PK CANC INST,BUFFALO,NY 14263.
RP KOZAK, CA (reprint author), NIAID,MOLEC MICROBIOL LAB,BLDG 4,ROOM 329,BETHESDA,MD 20892, USA.
FU NHGRI NIH HHS [HG00170-1]
NR 170
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S65
EP S80
DI 10.1007/BF00648423
PG 16
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900005
PM 1498444
ER

PT J
AU MOCK, BA
   NEUMANN, PE
   EPPIG, JT
   HUPPI, KE
AF MOCK, BA
   NEUMANN, PE
   EPPIG, JT
   HUPPI, KE
TI MOUSE CHROMOSOME-15
SO MAMMALIAN GENOME
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
CY OCT 11-15, 1992
CL BUFFALO, NY
SP APPL BIOSYST, BIO RAD LABS, BIOS LABS, BOEHRINGER MANNHEIM, CHARLES RIVER LABS, COSTAR, HOFFMAN LAROCHE, JAPAN IMMUNORES LABS, LAB PROD SALES, LIFE TECHNOL
ID C-MYC ONCOGENE; MURINE LEUKEMIA-VIRUS; RECOMBINANT INBRED STRAINS;
   SIMIAN SARCOMA-VIRUS; T-CELL LYMPHOMAS; GROWTH-FACTOR; THYROGLOBULIN
   GENE; THYMIC LYMPHOMAS; TOBACCO MOUSE; TRANSLOCATION BREAKPOINT
C1 CHILDRENS HOSP MED CTR,BOSTON,MA 02115.
   JACKSON LAB,BAR HARBOR,ME 04609.
RP MOCK, BA (reprint author), NCI,GENET LAB,BETHESDA,MD 20892, USA.
NR 215
TC 6
Z9 6
U1 1
U2 1
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 3
SI SI
BP S220
EP S232
DI 10.1007/BF00648433
PG 13
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA JT439
UT WOS:A1992JT43900015
PM 1498435
ER

PT J
AU WATSON, ML
   DEUSTACHIO, P
   MOCK, BA
   STEINBERG, AD
   MORSE, HC
   OAKEY, RJ
   HOWARD, TA
   ROCHELLE, JM
   SELDIN, MF
AF WATSON, ML
   DEUSTACHIO, P
   MOCK, BA
   STEINBERG, AD
   MORSE, HC
   OAKEY, RJ
   HOWARD, TA
   ROCHELLE, JM
   SELDIN, MF
TI A LINKAGE MAP OF MOUSE CHROMOSOME-1 USING AN INTERSPECIFIC CROSS
   SEGREGATING FOR THE GLD AUTOIMMUNITY MUTATION
SO MAMMALIAN GENOME
LA English
DT Review
ID MARIE-TOOTH NEUROPATHY; SYNDROME TYPE-II; GENETIC CONSTITUTION;
   CONSERVED LINKAGE; X-CHROMOSOME; DUFFY LOCUS; TRANSITION PROTEIN-1;
   ALKALINE-PHOSPHATASE; NUCLEOTIDE-SEQUENCE; MOLECULAR-CLONING
AB An interspecific backcross was used to define a high resolution linkage map of mouse Chromosome (Chr) 1 and to analyze the segregation of the generalized lymphoproliferative disease (gld) mutation. Mice homozygous for gld have multiple features of autoimmune disease. Analysis of up to 428 progeny from the backcross [(C3H/HeJ-gld X Mus spretus)F1 X C3H/HeJ-gld] established a map that spans 77.6 cM and includes 56 markers distributed over 34 ordered genetic loci. The gld mutation was mapped to a less than 1 cM segment on distal mouse Chr 1 using 357 gld phenotype-positive backcross mice. A second backcross, between the laboratory strains C57BL/6J and SWR/J, was examined to compare recombination frequency between selected markers on mouse Chr 1. Significant differences in crossover frequency were demonstrated between the interspecific backcross and the inbred laboratory cross for the entire interval studied. Sex difference in meiotic crossover frequency was also significant in the laboratory mouse cross. Two linkage groups known to be conserved between segments of mouse Chr 1 and the long arm of human Chrs 1 and 2 where fur-ther defined and a new conserved linkage group was identified that includes markers of distal mouse Chr 1 and human Chr 1, bands q32 to q42.
C1 DUKE UNIV,DEPT MED,DURHAM,NC 27710.
   DUKE UNIV,DEPT MICROBIOL,DURHAM,NC 27710.
   NYU MED CTR,DEPT BIOCHEM,NEW YORK,NY 10016.
   NYU MED CTR,KAPLAN CANC CTR,NEW YORK,NY 10016.
   NCI,GENET LAB,BETHESDA,MD 20892.
   NIAMSD,CELLULAR IMMUNOL SECT,BETHESDA,MD 20892.
   NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892.
RI Oakey, Rebecca/A-5958-2011; 
OI Oakey, Rebecca/0000-0003-2706-8139; Morse, Herbert/0000-0002-9331-3705
FU NIGMS NIH HHS [T32 GM 07171]
NR 103
TC 100
Z9 100
U1 0
U2 1
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PY 1992
VL 2
IS 3
BP 158
EP 171
DI 10.1007/BF00302874
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA HA601
UT WOS:A1992HA60100003
PM 1543910
ER

PT J
AU HAASCH, ML
   QUARDOKUS, EM
   SUTHERLAND, LA
   GOODRICH, MS
   PRINCE, R
   COOPER, KR
   LECH, JJ
AF HAASCH, ML
   QUARDOKUS, EM
   SUTHERLAND, LA
   GOODRICH, MS
   PRINCE, R
   COOPER, KR
   LECH, JJ
TI CYP1A1 PROTEIN AND MESSENGER-RNA IN TELEOSTS AS AN ENVIRONMENTAL
   BIOINDICATOR - LABORATORY AND ENVIRONMENTAL-STUDIES
SO MARINE ENVIRONMENTAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 6TH INTERNATIONAL SYMP ON RESPONSES OF MARINE ORGANISMS TO POLLUTANTS
CY APR 24-26, 1991
CL WOODS HOLE OCEANOG INST, WOODS HOLE, MA
SP US EPA, WOODS HOLE OCEANOG INST, COASTAL RES CTR, US NATL OCEAN & ATMOSPHER ADM, WOODS HOLE OCEANOG INST, SEA GRANT PROGRAM
HO WOODS HOLE OCEANOG INST
ID BETA-NAPHTHOFLAVONE; RAINBOW-TROUT; STENOTOMUS-CHRYSOPS; LIVER;
   3-METHYLCHOLANTHRENE; CYTOCHROME-P-450; SCUP; FISH
AB Teleosts are exposed, in the environment, to a number of chemicals that are capable of inducing hepatic cytochrome P450 monooxygenase activity. This induction has been described as a most sensitive biological indicator of the presence of certain classes of chemicals in water. The concept of a bioindicator, as applied here, is derived from the idea that a toxic effect will be manifested at the subcellular level before effects will be apparent at higher levels of biological organization. Laboratory and environmental induction of hepatic cytochrome P450 CYP1A1 (P450IA1) was investigated using catalytic activity, immunodetection and nucleic acid hybridization. Rainbow trout and largemouth bass were exposed, underflow-through conditions, to beta-naphthoflavone (beta-NF), a known CYP1A1 inducer, at concentrations ranging from 0-625 to 500 mug beta-NF/liter for periods of 1 to 21 days. At concentrations of 50-500 mug beta-NF/liter, ethoxyresorufin-O-deethylase (EROD) activity and immunoreactive CYP1A1 levels were induced, but the induction was inversely related to the beta-NF concentration. At these same concentrations, hybridizable CYP1A1 mRNA was increased at all concentrations over time and was induced at least up to 7 days of beta-NF treatment. At concentrations of 0.625-10.0 mug beta-NF/liter, EROD activity, immunoreactive protein and hybridizable mRNA were increased in a concentration-dependent manner. Environmental exposure of largemouth bass, placed in cages in water known to be contaminated with polychlorinated biphenyls, had elevated (six-fold) EROD activity at 3 and 7 days. Killifish taken from a TCDD-contaminated site had three-fold higher EROD activity and CYP1A1 mRNA, as well as increased immunoreactive protein, than killifish from a 'clean' site. These data indicate the efficacy of using nucleic acid hybridization of CYP1A1 mRNA as a bioindicator of environmental contamination.
C1 RUTGERS STATE UNIV,JOINT GRAD PROGRAM TOXICOL,PISCATAWAY,NJ 08854.
RP HAASCH, ML (reprint author), MED COLL WISCONSIN,DEPT PHARMACOL & TOXICOL,NIEHS,CTR AQUAT BIOMED RES CORE,MILWAUKEE,WI 53226, USA.
NR 13
TC 27
Z9 27
U1 1
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
SN 0141-1136
J9 MAR ENVIRON RES
JI Mar. Environ. Res.
PY 1992
VL 34
IS 1-4
BP 139
EP 145
DI 10.1016/0141-1136(92)90098-7
PG 7
WC Environmental Sciences; Marine & Freshwater Biology; Toxicology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
   Toxicology
GA KB005
UT WOS:A1992KB00500026
ER

PT J
AU NICHOLSON, HS
   MULVIHILL, JJ
   BYRNE, J
AF NICHOLSON, HS
   MULVIHILL, JJ
   BYRNE, J
TI LATE EFFECTS OF THERAPY IN ADULT SURVIVORS OF OSTEOSARCOMA AND EWING
   SARCOMA
SO MEDICAL AND PEDIATRIC ONCOLOGY
LA English
DT Article
DE SECOND CANCER; FERTILITY; DISABILITY
ID CHILDHOOD-CANCER; CHILDREN; TUMORS
AB To study the late consequences of primary bone cancer, we interviewed 82 osteosarcoma and 29 Ewing's sarcoma survivors regarding their health, fertility and offspring, employment, annual income, and activities of daily living. All subjects had been diagnosed before age 20 (mean age, 14.6 years), had survived at least 5 years from diagnosis, and were at least 21 years of age. On average, they were 32.5 years of age at interview. As controls, 151 siblings were interviewed.
   During the follow-up period, eight survivors had died, and eight survivors had been diagnosed with a second malignancy (7.2%; P = .002). No other health condition distinguished survivors from controls. Although the survivors were more likely than controls to have some difficulty climbing stairs and to have had employment disability, employment status and annual income at follow-up were similar. Deficits in marriage and fertility were not significant.
   Adult survivors of primary bone tumors diagnosed during childhood or adolescence are at high risk for second malignancies and premature death, making continued medical follow-up of utmost importance. Despite the physical impairment following limb amputation for many, the majority of outcomes we measured did not differ from controls, suggesting few adverse psychosocial outcomes in this group of cancer survivors.
C1 NCI,CLIN EPIDEMIOL BRANCH,BETHESDA,MD 20892.
RP NICHOLSON, HS (reprint author), CHILDRENS NATL MED CTR,DEPT HEMATOL ONCOL,111 MICHIGAN AVE NW,WASHINGTON,DC 20010, USA.
NR 17
TC 64
Z9 64
U1 0
U2 4
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0098-1532
J9 MED PEDIATR ONCOL
JI Med. Pediatr. Oncol.
PY 1992
VL 20
IS 1
BP 6
EP 12
DI 10.1002/mpo.2950200103
PG 7
WC Oncology; Pediatrics
SC Oncology; Pediatrics
GA GV593
UT WOS:A1992GV59300002
PM 1727214
ER

PT J
AU HAUPT, R
   BYRNE, J
   CONNELLY, RR
   MOSTOW, EN
   AUSTIN, DF
   HOLMES, GR
   HOLMES, FF
   LATOURETTE, HB
   TETA, MJ
   STRONG, LC
   MYERS, MH
   MULVIHILL, JJ
AF HAUPT, R
   BYRNE, J
   CONNELLY, RR
   MOSTOW, EN
   AUSTIN, DF
   HOLMES, GR
   HOLMES, FF
   LATOURETTE, HB
   TETA, MJ
   STRONG, LC
   MYERS, MH
   MULVIHILL, JJ
TI SMOKING-HABITS IN SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER
SO MEDICAL AND PEDIATRIC ONCOLOGY
LA English
DT Article
DE CHILDHOOD CANCER; CANCER SURVIVORS; SMOKING; CANCER TREATMENT; LATE
   EFFECTS
ID LONG-TERM SURVIVORS; QUIT; PERSPECTIVE; SMOKERS
AB Because of their increased risk for second cancers, childhood cancer survivors are people who really should not smoke, but available evidence suggests that they do.  We studied the smoking habits of long-term childhood cancer survivors in data collected from 1289 adult survivors of childhood cancer and 1930 of their sibling controls.  Survivors were diagnosed with cancer between 1945 and 1974 when they were less than 20 years old.  Using matched analyses that controlled for the influence of family, survivors were 8% less likely than controls to be current smokers, 13% less likely to be ever-smokers, but 12% less likely to have quit smoking; these differences were not statistically significant.  In a logistic regression analysis there was a significant difference by year of diagnosis for current smoking rate ratios (RR); survivors were less likely to be current smokers if diagnosed in recent years (RR = 0.76; 95% confidence intervals = 0.58-0.98, between 1965-74) and quite similar to controls if diagnosed in earlier years (RR = 1.05 between 1945 and 1954).
   In our group of long-term cancer survivors, the reduction in current smoking came about because survivors were more inclined never to start smoking than controls.  Once addicted to tobacco, they were less likely to quit.  While the fact that survivors are less likely to start smoking is encouraging, the persistence of smoking habits strongly suggests the need for continuing efforts to prevent smoking in this most vulnerable group.
C1 CALIF DEPT HLTH SERV,CALIF TUMOR REGISTRY,BERKELEY,CA.
   UNIV KANSAS,DEPT PEDIAT & PREVENT MED,LAWRENCE,KS 66045.
   UNIV KANSAS,DEPT INTERNAL MED,LAWRENCE,KS 66045.
   UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH,IOWA CITY,IA 52242.
   YALE UNIV,CONNECTICUT CANC EPIDEMIOL UNIT,NEW HAVEN,CT 06520.
   UNIV TEXAS,DEPT EXPTL PEDIAT,HOUSTON,TX 77025.
RP HAUPT, R (reprint author), NCI,CLIN EPIDEMIOL BRANCH,EXECUT PLAZA N,ROOM 400,BETHESDA,MD 20892, USA.
RI Haupt, Riccardo/C-2237-2012
NR 20
TC 60
Z9 60
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0098-1532
J9 MED PEDIATR ONCOL
JI Med. Pediatr. Oncol.
PY 1992
VL 20
IS 4
BP 301
EP 306
DI 10.1002/mpo.2950200406
PG 6
WC Oncology; Pediatrics
SC Oncology; Pediatrics
GA HZ956
UT WOS:A1992HZ95600005
PM 1608351
ER

PT J
AU ROTH, BJ
   ALTMAN, KW
AF ROTH, BJ
   ALTMAN, KW
TI STEADY-STATE POINT-SOURCE STIMULATION OF A NERVE CONTAINING AXONS WITH
   AN ARBITRARY DISTRIBUTION OF DIAMETERS
SO MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
LA English
DT Article
DE BIDOMAIN; FUNCTIONAL ELECTRICAL STIMULATION; NERVE
ID BUNDLE STIMULATION; EXCITATION; MODELS
AB The paper extends a mathematical model for point-source electrical stimulation of a nerve.  In the original model, it was assumed that all the axons in the nerve have the same diameter.  In this paper the model is extended to represent a nerve with an arbitrary distribution of axon diameters.  It is shown that the assumption of identical axons is justified for a typical human nerve if the 'representative' axon diameter is taken as the area-weighted average of the diameter distribution.
C1 DUKE UNIV,DEPT BIOMED ENGN,DURHAM,NC 27706.
RP ROTH, BJ (reprint author), NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BLDG 13,BETHESDA,MD 20892, USA.
RI Roth, Bradley/A-4920-2008
NR 22
TC 11
Z9 12
U1 0
U2 0
PU PETER PEREGRINUS LTD
PI HERTS
PA SOUTHGATE HOUSE STEVENAGE PO BOX 8, HERTS, ENGLAND SG1 1HQ
SN 0140-0118
J9 MED BIOL ENG COMPUT
JI Med. Biol. Eng. Comput.
PD JAN
PY 1992
VL 30
IS 1
BP 103
EP 108
DI 10.1007/BF02446201
PG 6
WC Computer Science, Interdisciplinary Applications; Engineering,
   Biomedical; Mathematical & Computational Biology; Medical Informatics
SC Computer Science; Engineering; Mathematical & Computational Biology;
   Medical Informatics
GA HE496
UT WOS:A1992HE49600016
PM 1640741
ER

PT J
AU HUI, TE
   FISHER, DR
   PRESS, OW
   EARY, JF
   WEINSTEIN, JN
   BADGER, CC
   BERNSTEIN, ID
AF HUI, TE
   FISHER, DR
   PRESS, OW
   EARY, JF
   WEINSTEIN, JN
   BADGER, CC
   BERNSTEIN, ID
TI LOCALIZED BETA DOSIMETRY OF I-131-LABELED ANTIBODIES IN FOLLICULAR
   LYMPHOMA
SO MEDICAL PHYSICS
LA English
DT Article
ID MODELING ANALYSIS; RADIOIMMUNOTHERAPY; RADIONUCLIDES; TUMORS
AB The purpose of this study is to assess the multicellular dosimetry of I-131-labeled antibody in follicular lymphoma based on histological measurements on human tumor biopsy tissue. Photomicrographs of lymph node specimens were analyzed by first-order treatment to determine the mean values and statistical variations of the radii of follicles (260 +/- 90-mu-m), interfollicular distances (740 +/- 160-mu-m), and the number density of follicles [60 +/- 18 in a volume of (2 x 1480-mu-m)3]. Based on these measurements, two geometrical models were developed for localized beta dosimetry. The first, a regular cubic lattice model, assumes no variation in follicular radius of follicles and interfollicular distance. The second, a randomized distribution model, is a more complicated but more realistic representation of observed histological specimens. In this model, Monte Carlo methods were used to reconstruct the spatial distribution of follicles by stimulating the distribution of the radii of follicles, interfollicular distances, and the number density of follicles. Dose calculations were performed using Berger's point kernels for absorbed-dose distribution for beta particles in water, assuming the I-113-labeled antibodies as point sources. It was assumed that the activity concentration of the labeled antibody within the follicles was ten times the activity concentration in the interfollicular spaces. The spatial distribution of localized dose was calculated for a tumor having an average dose of 40 Gy. The localized dose was found to be highly nonuniform, ranging from 20 to 90 Gy, and varying by a factor of about 2 from the average tumor dose. Most of the tissue (70%-80% by volume) was found to receive a lower dose than the average tumor dose. No significant difference in localized dose distribution was found between the regular cubic lattice model and the randomized distribution model, suggesting that sometimes a simple geometrical model may be adequate as a starting point for dosimetry of more complex situations. Finally, the localized dose distribution is discussed in terms of its usefulness for extracting information such as the mean dose, the spatial variation of dose, and the fraction of tissue receiving various absorbed doses. An approach for applying localized dosimetry to improve the estimated cell-killing efficiency is suggested.
C1 UNIV WASHINGTON, MED CTR, SEATTLE, WA 98195 USA.
   NCI, BETHESDA, MD 20892 USA.
   FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA.
RP HUI, TE (reprint author), PACIFIC NW LAB, DEPT HLTH PHYS, K3-51,POB 999, RICHLAND, WA 99352 USA.
FU NCI NIH HHS [CA44991]
NR 16
TC 25
Z9 25
U1 0
U2 0
PU AMER INST PHYSICS
PI WOODBURY
PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999
SN 0094-2405
J9 MED PHYS
JI Med. Phys.
PD JAN-FEB
PY 1992
VL 19
IS 1
BP 97
EP 104
DI 10.1118/1.596932
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA HE208
UT WOS:A1992HE20800012
PM 1620064
ER

PT J
AU BROSSI, A
AF BROSSI, A
TI 15 YEARS OF RESEARCH OF BIOACTIVE ALKALOIDS
SO MEDICINAL RESEARCH REVIEWS
LA English
DT Review
ID CATECHOL O-METHYLTRANSFERASE; ION CHANNEL COMPLEX; LUKES-SORM DILACTAM;
   X-RAY-ANALYSIS; ANTIMALARIAL DRUG; NEUROTOXIN
   1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; DIACETYLDIHYDROFLUORESCEIN
   DADF; ANTICHOLINESTERASE ACTIVITY; STEREOCONTROLLED SYNTHESIS;
   ERYTHROSINE-DERIVATIVES
RP BROSSI, A (reprint author), NIDDKD,STRUCT BIOL LAB,NAT PROD SECT,BETHESDA,MD 20817, USA.
NR 148
TC 8
Z9 8
U1 1
U2 1
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0198-6325
J9 MED RES REV
JI Med. Res. Rev.
PD JAN
PY 1992
VL 12
IS 1
BP 1
EP 26
DI 10.1002/med.2610120102
PG 26
WC Chemistry, Medicinal; Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA GY081
UT WOS:A1992GY08100001
PM 1738243
ER

PT J
AU SPIEGEL, AM
AF SPIEGEL, AM
TI HETEROTRIMERIC GTP-BINDING PROTEINS - AN EXPANDING FAMILY OF SIGNAL
   TRANSDUCERS
SO MEDICINAL RESEARCH REVIEWS
LA English
DT Review
ID BETA-ADRENERGIC-RECEPTOR; NUCLEOTIDE REGULATORY PROTEIN; STIMULATORY
   G-PROTEIN; ALBRIGHTS HEREDITARY OSTEODYSTROPHY; CARBOXYL-TERMINAL
   DECAPEPTIDE; NUCLEOSIDE DIPHOSPHATE KINASE; MANNOSE 6-PHOSPHATE
   RECEPTOR; ALPHA-SUBUNIT; ADENYLYL CYCLASE; GAMMA-SUBUNIT
RP SPIEGEL, AM (reprint author), NIDDKD,MOLEC PATHOPHYSIOL BRANCH,BLDG 10,RM 8D-17,BETHESDA,MD 20892, USA.
NR 102
TC 12
Z9 12
U1 1
U2 1
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0198-6325
J9 MED RES REV
JI Med. Res. Rev.
PD JAN
PY 1992
VL 12
IS 1
BP 55
EP 71
DI 10.1002/med.2610120105
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA GY081
UT WOS:A1992GY08100004
PM 1738245
ER

PT J
AU WEINBERGER, M
   ELATTAR, I
   MARSHALL, D
   STEINBERG, SM
   REDNER, RL
   YOUNG, NS
   PIZZO, PA
AF WEINBERGER, M
   ELATTAR, I
   MARSHALL, D
   STEINBERG, SM
   REDNER, RL
   YOUNG, NS
   PIZZO, PA
TI PATTERNS OF INFECTION IN PATIENTS WITH APLASTIC-ANEMIA AND THE EMERGENCE
   OF ASPERGILLUS AS A MAJOR CAUSE OF DEATH
SO MEDICINE
LA English
DT Article
ID FEBRILE NEUTROPENIC PATIENTS; GRANULOCYTOPENIC CANCER-PATIENTS; EMPIRIC
   ANTIBIOTIC-THERAPY; ANTI-THYMOCYTE GLOBULIN; PARA-NASAL SINUSES;
   RANDOMIZED TRIAL; PLUS AMIKACIN; INITIAL THERAPY;
   GENTAMICIN-CARBENICILLIN; ANTIMICROBIAL THERAPY
C1 NCI,CLIN ONCOL PROGRAM,PEDIAT BRANCH,INFECT DIS SECT,BLDG 10,ROOM 13N240,BETHESDA,MD 20892.
   NCI,CLIN ONCOL PROGRAM,BIOSTAT & DATA MANAGEMENT SECT,BETHESDA,MD 20892.
   NIH,CLIN HEMATOL BRANCH,BETHESDA,MD 20892.
NR 81
TC 90
Z9 93
U1 0
U2 2
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0025-7974
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 1992
VL 71
IS 1
BP 24
EP 43
PG 20
WC Medicine, General & Internal
SC General & Internal Medicine
GA HA867
UT WOS:A1992HA86700003
PM 1549057
ER

PT J
AU CHEEVER, AW
   XU, YH
   MACEDONIA, JG
   COX, T
   HIENY, S
   SHER, A
AF CHEEVER, AW
   XU, YH
   MACEDONIA, JG
   COX, T
   HIENY, S
   SHER, A
TI THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF HEPATIC
   GRANULOMATOUS-DISEASE IN SCHISTOSOMA-MANSONI INFECTED MICE
SO MEMORIAS DO INSTITUTO OSWALDO CRUZ
LA English
DT Article; Proceedings Paper
CT 3RD INTERNATIONAL SYMP ON SCHISTOSOMIASIS / 3RD NATIONAL MEETING ON
   SCHISTOSOMIASIS
CY OCT 20-25, 1991
CL RECIFE, BRAZIL
SP FUNDACAO OSWALDO CRUZ, CTR PESQUISAS AGGEU MAGALHAES
DE SCHISTOSOMA MANSONI; CYTOKINES; PATHOGENESIS; IL-2; IL-4; IL-5;
   IFN-GAMMA
ID SUPPRESSOR EFFECTOR FACTOR; MOLECULAR-BASIS; LYMPHOCYTES-T; IL-2
AB Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.g. IL-4 and IL-5) are augmented after egg laying begins while Th1 responses (IL-2 and IFN-gamma) are down regulated in S. mansoni infected mice. Treatment of mice with anti-IL-5 monoclonal antibodies (Mab) suppressed the eosinophil response almost completely but did not affect granuloma size and slightly increased hepatic fibrosis. Anti-IL-4 treatment abolished IgE responses in infected mice and decreased hepatic fibrosis slightly. Anti-IFN-gamma treatment had no effect on hepatic pathology. Anti-IL-2 treatment decreased granuloma size significantly and decreased hepatic fibrosis markedly. Anti-IL-2 treatment dramatically decreased IL-5 secretion by splenic cells in vitro and decreased peripheral blood and tissue eosinophilia. In contrast IL-4 secretion was unaffected and serum IgE was normal or increased. IL-2 and IFN-gamma secretion by splenic cells of treated mice were slightly but not significantly increased suggesting that anti-IL-2 treatment is affecting Th2 rather than Th1 responses.
RP CHEEVER, AW (reprint author), NIAID,PARASIT DIS LAB,BETHESDA,MD 20892, USA.
NR 15
TC 16
Z9 17
U1 0
U2 0
PU MEM INST OSWALDO CRUZ
PI RIO DE JANEIRO
PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL
SN 0074-0276
J9 MEM I OSWALDO CRUZ
JI Mem. Inst. Oswaldo Cruz
PY 1992
VL 87
SU 4
BP 81
EP 85
PG 5
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA LB150
UT WOS:A1992LB15000012
PM 1343930
ER

PT J
AU KASLOW, DC
   BATHURST, IC
   ISAACS, SN
   KEISTER, DB
   MOSS, B
   BARR, PJ
AF KASLOW, DC
   BATHURST, IC
   ISAACS, SN
   KEISTER, DB
   MOSS, B
   BARR, PJ
TI INDUCTION OF PLASMODIUM-FALCIPARUM TRANSMISSION-BLOCKING ANTIBODIES BY
   RECOMBINANT PFS25
SO MEMORIAS DO INSTITUTO OSWALDO CRUZ
LA English
DT Article; Proceedings Paper
CT 4TH INTERNATIONAL CONGRESS ON MALARIA AND BABESIOSIS
CY AUG 13-17, 1991
CL RIO DE JANEIRO, BRAZIL
SP FDN MARCEL MERIEUX, FUNDACAO NACL SAUDE, CONSELHO NACL DESENVOLVIMENTO CIENT & TECNOL, FINANCIADORA ESTUDOS & PROJETOS, FAO, PAN AMER HLTH ORG, BANCO BRASILEIRO DESCONTOS SA, COODENACAO APERFEICOAMENTO PESSOAL NIVEL SUPER, CARL ZEISS BRASIL, BRIT COUNCIL
RP KASLOW, DC (reprint author), NIAID,PARASIT DIS LAB,MALARIA SECT,BLDG 4,ROOM B1-37,BETHESDA,MD 20892, USA.
NR 0
TC 13
Z9 13
U1 0
U2 0
PU MEM INST OSWALDO CRUZ
PI RIO DE JANEIRO
PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL
SN 0074-0276
J9 MEM I OSWALDO CRUZ
JI Mem. Inst. Oswaldo Cruz
PY 1992
VL 87
SU 3
BP 175
EP 177
PG 3
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA LE918
UT WOS:A1992LE91800029
PM 1343687
ER

PT J
AU CHEEVER, AW
AF CHEEVER, AW
TI PATHOGENESIS OF SCHISTOSOMA-MANSONI INFECTION
SO MEMORIAS DO INSTITUTO OSWALDO CRUZ
LA English
DT Article; Proceedings Paper
CT 3RD INTERNATIONAL SYMP ON SCHISTOSOMIASIS / 3RD NATIONAL MEETING ON
   SCHISTOSOMIASIS
CY OCT 20-25, 1991
CL RECIFE, BRAZIL
SP FUNDACAO OSWALDO CRUZ, CTR PESQUISAS AGGEU MAGALHAES
DE SCHISTOSOMIASIS; SCHISTOSOMA-MANSONI; MICE; PATHOGENESIS
ID MURINE SCHISTOSOMIASIS; GRANULOMA-FORMATION; HEPATIC-FIBROSIS; MICE;
   IL-2; EGG
AB In this paper a discussion is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of ''processes'', ''mediators'', ''strategies for study'' and ''disease'' These concepts overlap considerably. Regarding ''processes'', granulomas, fibrosis and vasculitis are discussed The role of mediators, including cells, antibodies and immune complexes, cytokines and distal mediators is commented as related to the pathological processes occuring in schistosomiasis.
   Finally, strategies for study are presented, followed by a discussion on the etiopathogenesis of the different clinical stages and pathologic manifestations of schistosomiasis mansoni.
RP CHEEVER, AW (reprint author), NIAID,PARASIT DIS LAB,BETHESDA,MD 20892, USA.
NR 28
TC 4
Z9 5
U1 0
U2 0
PU MEM INST OSWALDO CRUZ
PI RIO DE JANEIRO
PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL
SN 0074-0276
J9 MEM I OSWALDO CRUZ
JI Mem. Inst. Oswaldo Cruz
PY 1992
VL 87
SU 4
BP 337
EP 340
PG 4
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA LB150
UT WOS:A1992LB15000055
PM 1343920
ER

PT J
AU RANDAZZO, PA
   WEISS, O
   KAHN, RA
AF RANDAZZO, PA
   WEISS, O
   KAHN, RA
TI PREPARATION OF RECOMBINANT ADP-RIBOSYLATION FACTOR
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID GTP-BINDING-PROTEIN; CHOLERA-TOXIN; REGULATORY COMPONENT;
   ADENYLATE-CYCLASE; NUCLEOTIDE-BINDING; RNA-POLYMERASE; EXPRESSION;
   COFACTOR; BOVINE; GENES
RP NCI, DIV CANC TREATMENT, BIOL CHEM LAB, BETHESDA, MD 20892 USA.
NR 28
TC 61
Z9 61
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 1992
VL 219
BP 362
EP 369
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA KL578
UT WOS:A1992KL57800034
PM 1488009
ER

PT J
AU HARMON, JT
   GRECO, NJ
   JAMIESON, GA
AF HARMON, JT
   GRECO, NJ
   JAMIESON, GA
TI ISOLATION OF HUMAN PLATELET PLASMA-MEMBRANES BY GLYCEROL LYSIS
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID THROMBIN; POLYPEPTIDES
C1 AMER RED CROSS,HOLLAND LAB,DEPT CELL BIOL,ROCKVILLE,MD 20855.
RP HARMON, JT (reprint author), NIDDKD,DIV DIABET ENDOCRINOL & METAB DIS,BETHESDA,MD 20892, USA.
NR 10
TC 11
Z9 11
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0076-6879
J9 METHOD ENZYMOL
JI Method Enzymol.
PY 1992
VL 215
BP 32
EP 36
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA KL850
UT WOS:A1992KL85000004
PM 1435333
ER

PT J
AU DANIEL, JL
   SELLERS, JR
AF DANIEL, JL
   SELLERS, JR
TI PURIFICATION AND CHARACTERIZATION OF PLATELET MYOSIN
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID LIGHT CHAIN KINASE; PHOSPHORYLATION; ACTIN
C1 NHLBI,MOLEC CARDIOL LAB,BETHESDA,MD 20892.
   TEMPLE UNIV,THROMBOSIS RES CTR,PHILADELPHIA,PA 19140.
RP DANIEL, JL (reprint author), TEMPLE UNIV,DEPT PHARMACOL,PHILADELPHIA,PA 19140, USA.
NR 19
TC 40
Z9 40
U1 1
U2 3
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0076-6879
J9 METHOD ENZYMOL
JI Method Enzymol.
PY 1992
VL 215
BP 78
EP 88
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA KL850
UT WOS:A1992KL85000008
PM 1435345
ER

PT J
AU HENRY, ER
   HOFRICHTER, J
AF HENRY, ER
   HOFRICHTER, J
TI SINGULAR VALUE DECOMPOSITION - APPLICATION TO ANALYSIS OF
   EXPERIMENTAL-DATA
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID PRINCIPAL COMPONENT ANALYSIS; ACID BASE MIXTURES; KINETICS EXPERIMENTS;
   CIRCULAR-DICHROISM; REDOX PROPERTIES; OPTICAL-SPECTRA; RESOLUTION;
   SPECTROSCOPY; CYTOCHROMES-AA3; TRANSITIONS
RP HENRY, ER (reprint author), NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892, USA.
RI Henry, Eric/J-3414-2013
OI Henry, Eric/0000-0002-5648-8696
NR 36
TC 467
Z9 469
U1 8
U2 79
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0076-6879
J9 METHOD ENZYMOL
JI Method Enzymol.
PY 1992
VL 210
BP 129
EP 192
PG 64
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JC222
UT WOS:A1992JC22200008
ER

PT J
AU KNUTSON, JR
AF KNUTSON, JR
TI ALTERNATIVES TO CONSIDER IN FLUORESCENCE DECAY ANALYSIS
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID TIME-RESOLVED FLUORESCENCE; LEAST-SQUARES; TRYPTOPHAN; RESOLUTION;
   KINETICS
RP KNUTSON, JR (reprint author), NHLBI,CELL BIOL LAB,BETHESDA,MD 20892, USA.
NR 36
TC 6
Z9 6
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0076-6879
J9 METHOD ENZYMOL
JI Method Enzymol.
PY 1992
VL 210
BP 357
EP 374
PG 18
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JC222
UT WOS:A1992JC22200016
PM 1584041
ER

PT J
AU WEBBER, KO
   HAJRA, AK
AF WEBBER, KO
   HAJRA, AK
TI DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE
SO METHODS IN ENZYMOLOGY
LA English
DT Review
ID GUINEA-PIG LIVER; PEROXISOMES; BIOSYNTHESIS
C1 UNIV MICHIGAN,NEUROSCI LAB,ANN ARBOR,MI 48109.
RP WEBBER, KO (reprint author), NHLBI,DEPT BIOCHEM GENET,BETHESDA,MD 20892, USA.
NR 14
TC 14
Z9 14
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495
SN 0076-6879
J9 METHOD ENZYMOL
JI Method Enzymol.
PY 1992
VL 209
BP 92
EP 98
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA JB764
UT WOS:A1992JB76400010
PM 1495441
ER

PT J
AU LEVINE, PH
   NEEQUAYE, J
   YADAV, M
   CONNELLY, R
AF LEVINE, PH
   NEEQUAYE, J
   YADAV, M
   CONNELLY, R
TI GEOGRAPHIC ETHNIC-DIFFERENCES IN HUMAN HERPESVIRUS-6 ANTIBODY PATTERNS
SO MICROBIOLOGY AND IMMUNOLOGY
LA English
DT Article
ID EXANTHEM SUBITUM; VIRUS; IDENTIFICATION; SEQUENCES; LYMPHOMA; HHV-6;
   HBLV
AB Serum samples from healthy adults in four geographic/ethnic groups (Ghanaian Blacks, Malaysian Chinese, Malaysian Indians and United States Causcaians) were tested under code for antibodies to human herpesvirus-6 (HHV-6).  The prevalence and titer of HHV-6 antibody in the healthy Ghanaians were significantly higher than in the Malaysian Chines; United States Caucasians and Malaysian Indians had intermediate prevalence and titer of antibodies.  Thus far, no specific differences in HHV-6-associated diseases have been noted between geographic/ethnic groups with these marked variations in antibody patterns.
C1 UNIV GHANA,SCH MED,LEGON,GHANA.
   UNIV MALAYA,KUALA LUMPUR 2211,MALAYSIA.
RP LEVINE, PH (reprint author), NCI,BETHESDA,MD 20892, USA.
NR 15
TC 11
Z9 11
U1 0
U2 0
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 4-16 YAYOI 2-CHOME, BUNKYO-KU, TOKYO 113, JAPAN
SN 0385-5600
J9 MICROBIOL IMMUNOL
JI Microbiol. Immunol.
PY 1992
VL 36
IS 2
BP 169
EP 172
PG 4
WC Immunology; Microbiology
SC Immunology; Microbiology
GA HH365
UT WOS:A1992HH36500007
PM 1316534
ER

PT J
AU LARDELLI, P
   MANZANO, D
   STEINBERG, SM
   MADARIAGA, L
   ANTON, I
   CISTERNA, R
AF LARDELLI, P
   MANZANO, D
   STEINBERG, SM
   MADARIAGA, L
   ANTON, I
   CISTERNA, R
TI CORRELATIVE DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) ANTIGEN P24
   AND EPSTEIN-BARR-VIRUS DNA INVITRO - CLINICAL INFLUENCE ON HIV-INFECTION
SO MICROBIOLOGY AND IMMUNOLOGY
LA English
DT Note
ID NUCLEIC-ACID HYBRIDIZATION; AIDS
AB The existence of molecular transactions between EBV and HIV-1, as well as reactivations of EBV latent infections in AIDS patients, have been recently documented.  In order to shed more light on the putative association between EBV and HIV, and its role in the evolution to AIDS, we have determined simultaneously p24 protein and EBV DNA in culture supernatants of peripheral blood mononuclear cells from 47 individuals suspected of having HIV infection.  The results of the in vitro assays were correlated with the clinical stage of the individuals and their serologic status to EBV.  Statistical analysis showed a concordance between HIV infection and in vitro detection of EBV DNA (P<0.002); particularly, a strong correlation between the presence of EBV DNA and p24 in culture was observed (P<0.001). These results are consistent with the occurrence of viral interactions, manifested in vitro.  However, in our series, the appearance of EBV DNA in culture was not concomitant with an elevation of anti-VCA IgG titers, anti-EA titers or the development of symptomatology, suggestive of a reactivation of a latent EBV infection or a progression of HIV infection.  Therefore we conclude that, although interaction between both viruses may take place at the molecular level, there is no clear evidence of the repercussion that this event may have on the clinical course of HIV infection.
C1 NCI,BIOSTATIST & DATA MANAGEMENT SECT,BETHESDA,MD 20892.
RP LARDELLI, P (reprint author), UNIV BASQUE COUNTRY,SCH MED,DEPT MICROBIOL & IMMUNOL,POB 699,BILBAO,SPAIN.
NR 9
TC 1
Z9 1
U1 1
U2 1
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 4-16 YAYOI 2-CHOME, BUNKYO-KU, TOKYO 113, JAPAN
SN 0385-5600
J9 MICROBIOL IMMUNOL
JI Microbiol. Immunol.
PY 1992
VL 36
IS 8
BP 905
EP 909
PG 5
WC Immunology; Microbiology
SC Immunology; Microbiology
GA JP075
UT WOS:A1992JP07500014
PM 1335543
ER

PT J
AU BARR, JK
   JOHNSON, KW
   WARSHAW, LJ
AF BARR, JK
   JOHNSON, KW
   WARSHAW, LJ
TI SUPPORTING THE ELDERLY - WORKPLACE PROGRAMS FOR EMPLOYED CAREGIVERS
SO MILBANK QUARTERLY
LA English
DT Article
ID DISABLED ELDERS; CARE
AB An aging population and extended longevity are increasing the number of older people needing informal and family support. At the same time, women, the traditional caregivers, have entered the work force in record numbers. Consequently, concerns about how to care for dependent family members have become workplace issues. In response to the needs of employees who care for family members, employers have produced an array of policies, benefits, and programs, including flexible work schedules and information and referral services. Although these programs are a valuable complement to community services and government initiatives, relatively few employers have recognized the potential effects of caregiving on absenteeism, productivity, and turnover; even fewer have responded with workplace programs directed to the needs of heir caregiving employees. To fill the gap, the government is considering mandating employee benefits, such as leave time for family illness. Community services are increasingly being directed to the needs of older people and their caregivers.
C1 NIA,BETHESDA,MD 20892.
RP BARR, JK (reprint author), NEW YORK BUSINESS GRP HLTH INC,622 3RD AVE,34TH FLOOR,NEW YORK,NY 10017, USA.
NR 51
TC 14
Z9 14
U1 0
U2 3
PU BLACKWELL PUBLISHERS
PI CAMBRIDGE
PA 350 MAIN STREET, STE 6, CAMBRIDGE, MA 02148-5023
SN 0887-378X
J9 MILBANK Q
JI Milbank Q.
PY 1992
VL 70
IS 3
BP 509
EP 533
DI 10.2307/3350133
PG 25
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA JR714
UT WOS:A1992JR71400006
PM 1406498
ER

PT J
AU BACHEVALIER, J
AF BACHEVALIER, J
TI CORTICAL VERSUS LIMBIC IMMATURITY - RELATIONSHIP TO INFANTILE AMNESIA
SO MINNESOTA SYMPOSIA ON CHILD PSYCHOLOGY
LA English
DT Review
ID ANTERIOR COMMUNICATING ARTERY; MEDIAL THALAMIC LESIONS; VISUAL
   RECOGNITION; SEX-DIFFERENCES; RHESUS-MONKEY; HIPPOCAMPAL-FORMATION;
   INTERTRIAL INTERVALS; MEDIODORSAL NUCLEUS; ALZHEIMERS-DISEASE; BASAL
   FOREBRAIN
RP BACHEVALIER, J (reprint author), NIMH, BETHESDA, MD 20892 USA.
NR 114
TC 23
Z9 23
U1 2
U2 17
PU LAWRENCE ERLBAUM ASSOC INC
PI MAHWAH
PA 10 INDUSTRIAL AVE, MAHWAH, NJ 07430-2262
SN 0076-9266
J9 MINN SYM CHILD PSYCH
JI Minn. Symp. Child Psychol.
PY 1992
VL 24
BP 129
EP 153
PG 25
WC Psychology, Developmental
SC Psychology
GA GX727
UT WOS:A1992GX72700005
ER

PT J
AU MCCUTCHAN, TF
   LAL, AA
   DOROSARIO, V
   WATERS, AP
AF MCCUTCHAN, TF
   LAL, AA
   DOROSARIO, V
   WATERS, AP
TI 2 TYPES OF SEQUENCE POLYMORPHISM IN THE CIRCUMSPOROZOITE GENE OF
   PLASMODIUM-FALCIPARUM
SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY
LA English
DT Article
DE MALARIA IMMUNITY; INDEPENDENT ORIGINS OF MUTATION; CIRCUMSPOROZOITE
   PROTEIN; CYTOTOXIC T-CELL
ID T-CELL RECOGNITION; MALARIA SPOROZOITES; PROTEIN GENE; EPITOPES;
   DOMAINS; REGIONS; INVIVO; STRAIN
AB Here we demonstrate two characteristically different classes or types of gene sequence variation in the circumsporozoite protein from Plasmodium falciparum.  Some patterns of sequence variation suggest, or are at least consistent with, Mendelian inheritance.  We show here that patterns of sequence variation at specific positions, however, introduce homoplasty (similarity or identity not directly attributable to common ancestry) into the relationship between parasites.  The demonstration of extensive homoplasy in a malaria gene raises questions about the validity of familial relationships established among parasites with polymorphic markers.  We suggest that homoplasy at particular positions could mark a site of biological pressure on the parasite where interaction of the site with factors in the environment affects the success of the parasite population.  This may well emphasize the importance of the circumsporozoite protein in malarial vaccine constructs as discussed below.  Further we offer an approach to structural analysis that demonstrates and quantitates the degree of homoplasy in particular positions of a protein.
C1 BIOMED RES INST,ROCKVILLE,MD.
RP MCCUTCHAN, TF (reprint author), NIAID,PARASIT DIS LAB,BETHESDA,MD 20892, USA.
RI Waters, Andy/C-9377-2009
OI Waters, Andy/0000-0001-8900-2982
NR 23
TC 28
Z9 28
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-6851
J9 MOL BIOCHEM PARASIT
JI Mol. Biochem. Parasitol.
PD JAN
PY 1992
VL 50
IS 1
BP 37
EP 46
DI 10.1016/0166-6851(92)90242-C
PG 10
WC Biochemistry & Molecular Biology; Parasitology
SC Biochemistry & Molecular Biology; Parasitology
GA GW362
UT WOS:A1992GW36200004
PM 1542315
ER

EF