FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Weissman, JD
   Hwang, JR
   Singer, DS
AF Weissman, JD
   Hwang, JR
   Singer, DS
TI Extensive interactions between HIV TAT and TAF(II)250
SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
LA English
DT Article
DE TAFII250; HIV TAT
ID RNA-POLYMERASE-II; IMMUNODEFICIENCY-VIRUS TYPE-1; GENERAL TRANSCRIPTION
   FACTORS; TERMINAL DOMAIN PHOSPHATASE; REPRESSES TRANSCRIPTION;
   HELA-CELLS; PROTEIN; EXPRESSION; PROMOTER; DEPHOSPHORYLATES
AB The HIV transactivator, Tat, has been shown to be capable of potent repression of transcription initiation. Repression is mediated by the C-terminal segment of Tat, which binds the TFIID component, TAF(II)250, although the site(s) of interaction were not defined previously. We now report that the interaction between Tat and TAFII250 is extensive and involves multiple contacts between the Tat protein and TAFII250. The C-terminal domain of Tat, which is necessary for repression of transcription initiation, binds to a segment of TAFII250 that encompasses its acetyl transferase (AT) domain (885-1034 amino acids (aa)). Surprisingly, the N-terminal segment of Tat, which contains its activation domains, also binds to TAF(II)250 and interacts with two discontinuous segments of TAFII250 located between 885 and 984 aa and 1120 and 1279 aa. Binding of Tat to the 885-984 aa segment of TAFII250 requires the cysteine-rich domain of Tat, but not the acidic or glutamine-rich domains. Binding by the N-terminal domain of Tat to the 1120-1279 aa TAFII250 segment does not involve the acidic, cysteine- or glutamine-rich domains. Repression of transcription initiation by Tat requires functional TAFII250. We now demonstrate that transcription of the HIV LTR does not depend on TAFII250 which may account for its resistance to Tat mediated repression. (C) 2001 Elsevier Science B.V. All rights reserved.
C1 NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
RP Weissman, JD (reprint author), NCI, Expt Immunol Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 37
TC 8
Z9 8
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4838
J9 BBA-PROTEIN STRUCT M
JI Biochim. Biophys. Acta-Protein Struct. Molec. Enzym.
PD MAR 9
PY 2001
VL 1546
IS 1
BP 156
EP 163
DI 10.1016/S0167-4838(01)00135-2
PG 8
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 414AZ
UT WOS:000167644900014
PM 11257518
ER

PT J
AU Kawai, H
   Allende, ML
   Wada, R
   Kono, M
   Sango, K
   Deng, CX
   Miyakawa, T
   Crawley, JN
   Werth, N
   Bierfreund, U
   Sandhoff, K
   Proia, RL
AF Kawai, H
   Allende, ML
   Wada, R
   Kono, M
   Sango, K
   Deng, CX
   Miyakawa, T
   Crawley, JN
   Werth, N
   Bierfreund, U
   Sandhoff, K
   Proia, RL
TI Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic
   seizures
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID B-SERIES GANGLIOSIDES; COMPLEX GANGLIOSIDES; NEURONAL DIFFERENTIATION;
   SYNTHASE; GENE; GLYCOSPHINGOLIPIDS; MODULATORS; METABOLISM; LACKING;
   DEFECTS
AB Gangliosides are a family of glycosphingolipids that contain sialic acid. Although they are abundant on neuronal cell membranes, their precise functions and importance in the central nervous system (CNS) remain largely undefined. We have disrupted the gene encoding GD3 synthase (GD3S), a sialyltransferase expressed in the CNS that is responsible for the synthesis of b-series gangliosides. GD3S-/- mice, even with an absence of b-series gangliosides, appear to undergo normal development and have a normal life span. To further restrict the expression of gangliosides, the GD3S mutant mice were crossbred with mice carrying a disrupted GalNAcT gene encoding beta1,4-N-acetylgalactosaminyltransferase. These double mutant mice expressed GM3 as their major ganglioside. In contrast to the single mutant mice, the double mutants displayed a sudden death phenotype and were extremely susceptible to induction of lethal seizures by sound stimulus. These results demonstrate unequivocally that gangliosides play an essential role in the proper functioning of the CNS.
C1 NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA.
   NIMH, Sect Behav Neuropharmacol, Expt Therapeut Branch, Bethesda, MD 20892 USA.
   Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany.
RP Proia, RL (reprint author), NIDDKD, Genet Dev & Dis Branch, NIH, Bldg 10,Rm 9N-314, Bethesda, MD 20892 USA.
RI Proia, Richard/A-7908-2012; Miyakawa, Tsuyoshi/A-7741-2008; deng,
   chuxia/N-6713-2016
OI Miyakawa, Tsuyoshi/0000-0003-0137-8200; 
NR 33
TC 148
Z9 150
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 9
PY 2001
VL 276
IS 10
BP 6885
EP 6888
DI 10.1074/jbc.C000847200
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 410MC
UT WOS:000167442900002
PM 11133999
ER

PT J
AU Hu, JX
   Reyes-Cruz, G
   Goldsmith, PK
   Spiegel, AM
AF Hu, JX
   Reyes-Cruz, G
   Goldsmith, PK
   Spiegel, AM
TI The venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor
   are not linked by disulfide bonds
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID METABOTROPIC GLUTAMATE-RECEPTOR; CALCIUM-SENSING RECEPTOR; CELL-SURFACE
   EXPRESSION; SIGNAL-TRANSDUCTION; EXTRACELLULAR DOMAIN; IDENTIFICATION;
   DIMERIZATION; CLONING
AB The extracellular N-terminal domain of the human Ca2+ receptor (hCaR) consists of a Venus's-flytrap (VFT) domain and a cysteine-rich (Cys-rich) domain. We have shown earlier that the Cys-rich domain is critical for signal transmission from the VFT domain to the seven-transmembrane domain. The VFT domain contains 10 cysteines: two of them (Cys(129) and Cys(131)) were identified as involved in intermolecular disulfide bonds necessary for homodimerization, and six others (Cys(60)- Cys(101), Cys(358)-Cys(395), and Cys(437)-Cys(449)) are predicted to form three intramolecular disulfide bonds. The Cys-rich domain contains nine cysteines, the involvement of which in disulfide bond formation has not been defined. In this work, we asked whether the remaining cysteines in the hCaR VFT, namely Cys(236) and Cys(482), form disulfide bond(s) with cysteines in the Cys-rich domain. We constructed mutant hCaRs with a unique tobacco etch virus (TEV) protease recognition site inserted between the VFT domain and the Cys-rich domain. These mutant hCaRs remain fully functional compared with the wild type hCaR. After TEV protease digestion of the mutant hCaR proteins, dimers of the VFT were identified on Western blot under nonreducing conditions. We concluded that there is no disulfide bond between the VFT and the Cys-rich domains in the hCaR.
C1 NIDCD, Mol Pathophysiol Sect, NIH, Bethesda, MD 20892 USA.
RP Hu, JX (reprint author), NIDCD, Mol Pathophysiol Sect, NIH, Bldg 10,Rm 8C-101,9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 19
TC 17
Z9 17
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 9
PY 2001
VL 276
IS 10
BP 6901
EP 6904
DI 10.1074/jbc.C000865200
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 410MC
UT WOS:000167442900006
PM 11238442
ER

PT J
AU Sztajer, H
   Gamain, B
   Aumann, KD
   Slomianny, C
   Becker, K
   Brigelius-Flohe, R
   Flohe, L
AF Sztajer, H
   Gamain, B
   Aumann, KD
   Slomianny, C
   Becker, K
   Brigelius-Flohe, R
   Flohe, L
TI The putative glutathione peroxidase gene of Plasmodium falciparum codes
   for a thioredoxin peroxidase
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID KAPPA-B ACTIVATION; MOLECULAR CHARACTERIZATION; HYDROPEROXIDE
   METABOLISM; SCHISTOSOMA-MANSONI; MALARIA PARASITE; CDNA SEQUENCE; HUMAN
   PLASMA; SELENIUM; SELENOENZYME; PROTEIN
AB A putative glutathione peroxidase gene (Swiss-Prot accession number Z 68200) of Plasmodium falciparum, the causative agent of tropical malaria, was expressed in Escherichia coli and purified to electrophoretic homogeneity, Like phospholipid hydroperoxide glutathione peroxidase of mammals, it proved to be monomeric, It was active with H2O2 and organic hydroperoxides but, unlike phospholipid hydroperoxide glutathione peroxidase, not with phosphatidylcholine hydroperoxide, With glutathione peroxidases it shares the ping pong mechanism with infinite V-max and K-m when analyzed with GSH as substrate, As a homologue with selenocysteine replaced by cysteine, its reactions with hydroperoxides and GSH are 3 orders of magnitude slower than those of the selenoperoxidases, Unexpectedly, the plasmodial enzyme proved to react faster with thioredoxins than with GSH and most efficiently with thioredoxin of P. falciparum (Swiss-Prot accession number 202664), It is therefore reclassified as thioredoxin peroxidase. With plasmodial thioredoxin, the enzyme also displays ping-pong kinetics, yet with a limiting K-m of 10 muM and a k(1)' of 0.55 s(-1). The apparent k(1)' for oxidation with cumene, t-butyl, and hydrogen peroxides are 2.0 x 10(4) M-1 s(-1) 3.3 x 10(3) M-1 s(-1), and 2.5 x 10(3) M-1 s(-1) respectively. k(2)' for reduction by autologous thioredoxin is 5.4 x 10(4) M-1 s(-1) (21.2 M-1 s(-1) for GSH), The newly discovered enzymatic function of the plasmodial gene product suggests a reconsideration of its presumed role in parasitic antioxidant defense.
C1 Tech Univ Braunschweig, Dept Biochem, D-38124 Braunschweig, Germany.
   NIAID, NIH, Bethesda, MD 20892 USA.
   Natl Biotechnol Ctr, D-38124 Braunschweig, Germany.
   Univ Sci & Tech Lille Flandres Artois, INSERM, EPI 9938, F-59655 Villeneuve Dascq, France.
   Univ Wurzburg, Res Ctr Infect Dis, D-97070 Wurzburg, Germany.
   German Inst Human Nutr, D-14558 Bergholz Rehbrucke, Germany.
RP Flohe, L (reprint author), Tech Univ Braunschweig, Dept Biochem, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
NR 54
TC 114
Z9 120
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 9
PY 2001
VL 276
IS 10
BP 7397
EP 7403
DI 10.1074/jbc.M008631200
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 410MC
UT WOS:000167442900074
PM 11087748
ER

PT J
AU Gutierrez-Cruz, G
   Van Heerden, AH
   Wang, K
AF Gutierrez-Cruz, G
   Van Heerden, AH
   Wang, K
TI Modular motif, structural folds and affinity profiles of the PEVK
   segment of human fetal skeletal muscle titin
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HUMAN NEBULIN FRAGMENTS; VERTEBRATE SKELETAL; GLOBULAR-PROTEINS;
   ELASTICITY; FILAMENTS; STABILITY; EXTENSION; DOMAINS; EXTENSIBILITY;
   STIFFNESS
AB The extension of the PEVK segment of the giant elastic protein titin is a key event in the elastic response of striated muscle to passive stretch. PEVK behaves mechanically as an entropic spring and is thought to be a random coil. cDNA sequencing of human fetal skeletal PEVK reveals a modular motif with tandem repeats of modules averaging 28 residues and with superrepeats of seven;modules. Conformational studies of bacterially expressed 53-kDa fragment (TP1) by circular dichroism suggest; that this soluble protein contains substantial polyproline II (PPII) type left-handed helices. Urea and thermal titrations cause gradual and reversible decrease in PPII content. The absence of sharp melting in urea and thermal titrations suggests that there is no long range cooperativity among the PPII helices. Studies with solid phase and surface plasmon resonance assays indicate that TP1 interacts with actin and some but not all cloned nebulin fragments with high affinity. Interestingly, Ca2+/calmodulin and Ca2+/S100 abolish nebulin/PEVK interaction. We suggest that in aqueous solution) PEVK is an open and flexible chain of relatively stable structural folds of the polyproline II type. PEVK region of titin may be involved in interfilament association with thin filaments in a calcium/calmodulin-sensitive manner. This adhesion may modulate titin extensibility and elasticity.
C1 NIAMSD, Lab Phys Biol, NIH, Bethesda, MD 20892 USA.
   Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA.
RP Wang, K (reprint author), NIAMSD, Lab Phys Biol, NIH, Bldg 6,Rm 401, Bethesda, MD 20892 USA.
FU NIAMS NIH HHS [AR 45315]
NR 34
TC 62
Z9 63
U1 0
U2 5
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 9
PY 2001
VL 276
IS 10
BP 7442
EP 7449
DI 10.1074/jbc.M008851200
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 410MC
UT WOS:000167442900081
PM 11084039
ER

PT J
AU Clem, RJ
   Sheu, TT
   Richter, BWM
   He, WW
   Thornberry, NA
   Duckett, CS
   Hardwick, JM
AF Clem, RJ
   Sheu, TT
   Richter, BWM
   He, WW
   Thornberry, NA
   Duckett, CS
   Hardwick, JM
TI c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal
   fragment
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID UBIQUITIN-PROTEIN LIGASE; PROGRAMMED CELL-DEATH; APOPTOSIS PROTEINS;
   MAMMALIAN-CELLS; CYTOCHROME-C; BACULOVIRUS INHIBITOR; NMR STRUCTURE; BIR
   DOMAIN; IAP GENES; BCL-X(L)
AB Although:human c-IAP1 and c-IAP2 have been reported to-possess antiapoptotic activity against a variety of stimuli in several mammalian cell types, we observed that full-length c-IAP1 and c-IAP2 failed to protect cells from apoptosis induced by Bax overexpression, tumor necrosis factor alpha treatment or Sindbis virus infection. However, deletion of the C-terminal RING domains:of c-IAP1 and c-IAP2 restored antiapoptotic activity, indicating that this region negatively regulates the antiapoptotic function of the N-terminal BIR domain. This finding is consistent with the observation by others that the spacer region and RING domain of c-IAP1 functions as an E3 ligase, promoting autoubiquitination and degradation of c-IAP1. In addition, we found that c-IAP1 is cleaved during apoptosis to 52- and 35-kDa fragments. Both fragments contain the C-terminal end of c-IAP1 including the-RING finger. In vitro cleavage of c-IAP1 with apoptotic cell extracts or with purified recombinant caspase-3 produced similar fragments. Furthermore, transfection of cells with the spacer-RING domain alone Suppressed the antiapoptotic function of the N-terminal BIR domain of c-IAP1 and induced apoptosis, Optimal death-inducing activity of the spacer-RING required both the spacer region and the zinc-binding RING domain of c-IAP1 but did not require the caspase recruitment domain located within the spacer region, To the contrary, deletion of the caspase recruitment domain increased proapoptotic activity, apparently by stabilizing the C-terminal fragment.
C1 Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Sch Publ Hlth, Dept Neurol & Pharmacol & Mol Sci, Baltimore, MD 21205 USA.
   NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.
   Human Genome Sci Inc, Rockville, MD 20850 USA.
   Merck Res Labs, Dept Biochem, Rahway, NJ 07065 USA.
RP Hardwick, JM (reprint author), Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, E5140,615 N Wolfe St, Baltimore, MD 21205 USA.
NR 45
TC 86
Z9 88
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 9
PY 2001
VL 276
IS 10
BP 7602
EP 7608
DI 10.1074/jbc.M010259200
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 410MC
UT WOS:000167442900100
PM 11106668
ER

PT J
AU Elman, I
   Goldstein, DS
   Adler, CM
   Shoaf, SE
   Breier, A
AF Elman, I
   Goldstein, DS
   Adler, CM
   Shoaf, SE
   Breier, A
TI Inverse relationship between plasma epinephrine and testosterone levels
   during acute glucoprivation in healthy men
SO LIFE SCIENCES
LA English
DT Article
DE deoxyglucose; stress; catecholamines; norepinephrine; HVA; 5-HIAA
ID INSULIN-INDUCED HYPOGLYCEMIA; HOMOVANILLIC-ACID; 5-HYDROXYINDOLEACETIC
   ACID; NOREPINEPHRINE UPTAKE; CEREBROSPINAL-FLUID; BLOOD-FLOW;
   CATECHOLAMINES; STRESS; BRAIN; RATS
AB In healthy men, a decrease in plasma testosterone levels was observed in the context of metabolic stress. While physiological mechanisms underlying this response are unclear, there are several lines of evidence suggesting circulating epinephrine's influence on plasma testosterone levels. The purpose of this study was to directly relate stress-induced changes in plasma testosterone and epinephrine. The stressor used was blockade of glucose metabolism with pharmacological doses (40mg/kg) of 2 deoxyglucose (2DG). Arterial plasma samples from 10 healthy males were assayed at 20 minutes intervals for 60 minutes for the concentrations of testosterone, epinephrine and related biochemicals. Bolus administration of 2DG resulted in progressive decline in testosterone and increases in epinephrine and norepinephrine plasma levels (mean change from baseline: 29, 2530 and 186%, respectively). Inverse correlation was detected between both absolute (r(s)= -0.72; df=8; p=0.017) and baseline-corrected testosterone concentrations at the 60 minute time point and epinephrine area under the curve values. Our results suggest that adrenomedullary activation may be involved in stress-induced testosterone effects. The implications of these data for the understanding of the role of catecholamines in glucoprivic stress response are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.
C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat,Addict Serv, Boston, MA 02114 USA.
   NINDS, Clin Cardiol Sect, Bethesda, MD 20892 USA.
   NIMH, Expt Therapeut Branch, Bethesda, MD 20892 USA.
   NIAAA, Clin Studies Lab, Bethesda, MD 20892 USA.
   Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA.
   Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
RP Elman, I (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat,Addict Serv, 15 Parkman St WACC-812, Boston, MA 02114 USA.
NR 35
TC 15
Z9 15
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD MAR 9
PY 2001
VL 68
IS 16
BP 1889
EP 1898
DI 10.1016/S0024-3205(01)00982-1
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 412VQ
UT WOS:000167575400007
PM 11292066
ER

PT J
AU Healy, B
AF Healy, B
TI vCJD: Broad US response required
SO SCIENCE
LA English
DT Editorial Material
C1 Amer Red Cross, Washington, DC 20006 USA.
   NIH, Bethesda, MD 20892 USA.
RP Healy, B (reprint author), Amer Red Cross, Washington, DC 20006 USA.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 9
PY 2001
VL 291
IS 5510
BP 1859
EP 1859
DI 10.1126/science.291.5510.1859
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 409TK
UT WOS:000167401600001
PM 11245169
ER

PT J
AU Varmus, H
AF Varmus, H
TI Public health - Proliferation of National Institutes of Health
SO SCIENCE
LA English
DT Editorial Material
C1 Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   NIH, Bethesda, MD 20892 USA.
RP Varmus, H (reprint author), Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
NR 0
TC 5
Z9 5
U1 0
U2 0
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 9
PY 2001
VL 291
IS 5510
BP 1903
EP +
DI 10.1126/science.1059063
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 409TK
UT WOS:000167401600027
PM 11245194
ER

PT J
AU Drayna, D
   Manichaikul, A
   de Lange, M
   Snieder, H
   Spector, T
AF Drayna, D
   Manichaikul, A
   de Lange, M
   Snieder, H
   Spector, T
TI Genetic correlates of musical pitch recognition in humans
SO SCIENCE
LA English
DT Article
ID ABSOLUTE PITCH; TWIN; TRAITS
AB We used a twin study to investigate the genetic and environmental contributions to differences in musical pitch perception abilities in humans. We administered a Distorted Tunes Test (DTT), which requires subjects to judge whether simple popular melodies contain notes with incorrect pitch, to 136 monozygotic twin pairs and 148 dizygotic twin pairs. The correlation of DTT scores between twins was estimated at 0.67 for monozygotic pairs and 0.44 for dizygotic pairs. Genetic model-fitting, techniques supported an additive genetic model, with heritability; estimated at 0.71 to 0.80, depending on how subjects were categorized, and with no effect of shared environment. DTT scores were only weakly correlated with measures of peripheral hearing. This suggests that variation in musical pitch recognition is primarily due to highly heritable differences in auditory functions not tested by conventional audiologic methods.
C1 Natl Inst Deafness & Other Commun Disorders, NIH, Rockville, MD 20850 USA.
   St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London SE1 7EH, England.
RP Drayna, D (reprint author), Med Coll Georgia, Georgia Prevent Inst, Bldg HS-1640, Augusta, GA 30912 USA.
RI Manichaikul, Ani/B-7726-2009; Spector, Tim/F-6533-2012
FU NIDCD NIH HHS [Z01-DC-00043-03]
NR 23
TC 151
Z9 156
U1 3
U2 12
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 9
PY 2001
VL 291
IS 5510
BP 1969
EP 1972
DI 10.1126/science.291.5510.1969
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 409TK
UT WOS:000167401600048
PM 11239158
ER

PT J
AU Abe, K
   Tumanov, A
   Ito, D
   Shakhov, AN
   Komschlies, KL
   Nedospasov, SA
AF Abe, K
   Tumanov, A
   Ito, D
   Shakhov, AN
   Komschlies, KL
   Nedospasov, SA
TI Deficiency of dendritic cell generation and migration in single and
   combined TNF/LT KO mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
   SAIC, Intramural Res Support Program, Frederick, MD 21702 USA.
   NCI, Expt Immunol Lab, Frederick, MD 21702 USA.
RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015;
   Nedospasov, Sergei/Q-7319-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1034
EP A1034
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201853
ER

PT J
AU Akilesh, S
   Eden, P
   Roopenian, D
   Dudley, M
AF Akilesh, S
   Eden, P
   Roopenian, D
   Dudley, M
TI Efficient chromosomal mapping of an MCA-induced tumor antigen by
   CTL-mediated immunoselection
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Jackson Lab, Bar Harbor, ME 04609 USA.
   Marywood Univ, Scranton, PA USA.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1207
EP A1207
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202848
ER

PT J
AU Bagenstose, LM
   Wahlsten, JL
   Chan, CC
   Bansch, D
   Wiggert, B
   Caspi, RR
AF Bagenstose, LM
   Wahlsten, JL
   Chan, CC
   Bansch, D
   Wiggert, B
   Caspi, RR
TI The role of IL-18 in modulation of Experimental Autoimmune Uveitis (EAU)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NEI, Bethesda, MD 20892 USA.
   BASF Biores Corp, Worcester, MA 01605 USA.
   NIH, LRCMB, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1066
EP A1066
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202043
ER

PT J
AU Bennett, AJ
   Sponberg, AC
   Graham, T
   Lindell, S
   Suomi, SG
   Higley, JD
   DePetrillo, PB
AF Bennett, AJ
   Sponberg, AC
   Graham, T
   Lindell, S
   Suomi, SG
   Higley, JD
   DePetrillo, PB
TI Initial alcohol exposure results in stress-dependent acute increases and
   subsequent decreases in CSF5-HIAA concentrations and cardiac signal
   complexity in alcohol-naive rhesus monkeys
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Poolesville, MD 20837 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A911
EP A911
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201139
ER

PT J
AU Beutler, KT
   Nielsen, J
   Masilamani, S
   Brooks, HL
   Knepper, MA
AF Beutler, KT
   Nielsen, J
   Masilamani, S
   Brooks, HL
   Knepper, MA
TI Changes in abundances of sodium transporters and sodium channel (ENaC)
   subunits in rat kidney in response to AT1 receptor blockade
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A787
EP A787
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200427
ER

PT J
AU Bird, GS
   Broad, LM
   Putney, JW
AF Bird, GS
   Broad, LM
   Putney, JW
TI Role of the phospholipase C inositol 1,4,5-triphosphate pathway in
   calcium release-activated calcium current (Icrac) and capacitative
   calcium entry
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1115
EP A1115
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202317
ER

PT J
AU Blanca, IR
   Bere, EW
   Young, HA
   Ortaldo, JR
AF Blanca, IR
   Bere, EW
   Young, HA
   Ortaldo, JR
TI Activation of human B lymphocytes by autologous NK cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1030
EP A1030
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201830
ER

PT J
AU Brooks, HL
   Chou, CL
   Verkman, AS
   Knepper, MA
AF Brooks, HL
   Chou, CL
   Verkman, AS
   Knepper, MA
TI Corticalization of inner medullary collecting duct in mice with ablation
   of the countercurrent multiplier process due to deletion of the
   Aquaporin-1 gene.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
   Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A851
EP A851
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200794
ER

PT J
AU Brown, KM
   Shevach, EM
AF Brown, KM
   Shevach, EM
TI CD4+CD25+suppressor cells regulate susceptibility to experimental
   allergic encephalomyelitis (EAE)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1218
EP A1218
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202913
ER

PT J
AU Caballero, B
   Clay, T
   Davis, S
   Ethelbah, B
   Holyrock, B
   Lohman, T
   Story, M
   Stevens, J
   Stephenson, L
   Stone, E
AF Caballero, B
   Clay, T
   Davis, S
   Ethelbah, B
   Holyrock, B
   Lohman, T
   Story, M
   Stevens, J
   Stephenson, L
   Stone, E
TI The Pathways obesity prevention study: Overview of design and
   measurements
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Johns Hopkins Univ, Baltimore, MD 21205 USA.
   Univ New Mexico, Albuquerque, NM 87131 USA.
   Univ Minnesota, Minneapolis, MN 55455 USA.
   Univ Arizona, Tucson, AZ 85721 USA.
   Univ N Carolina, Chapel Hill, NC 27515 USA.
   Gila River Indian Commun, Sacaton, AZ USA.
   NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 2
Z9 2
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1091
EP A1091
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202182
ER

PT J
AU Caplan, S
   Hartnell, LM
   Naslavsky, N
   Patterson, GH
   Lodge, R
   Bonifacino, JS
AF Caplan, S
   Hartnell, LM
   Naslavsky, N
   Patterson, GH
   Lodge, R
   Bonifacino, JS
TI Molecular cloning and characterization of human Vam6p/Vps39p: a novel
   protein involved in lysosome biogenesis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, Cell Biol & Metab Branch, Bethesda, MD 20892 USA.
   NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1175
EP A1175
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202663
ER

PT J
AU Carlson, BA
   Mushinski, JF
   Kwon, SY
   Henderson, DW
   Crain, PF
   Hatfield, DL
AF Carlson, BA
   Mushinski, JF
   Kwon, SY
   Henderson, DW
   Crain, PF
   Hatfield, DL
TI Role of anticodon loop of ASN and the PHE tRNAs in retroviral ribosomal
   frameshifting.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, BRL, NIH, Bethesda, MD 20892 USA.
   NCI, LMB, NIH, Bethesda, MD 20892 USA.
   Seoul Natl Univ, LMG, IMBG, Seoul 151742, South Korea.
   Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A900
EP A900
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201074
ER

PT J
AU Cavacini, LA
   Eder, JP
   Kufe, DW
   Schlom, J
   Posner, MR
AF Cavacini, LA
   Eder, JP
   Kufe, DW
   Schlom, J
   Posner, MR
TI Antibodies to prostate surface antigens in patients immunized with
   prostate specific antigen (PSA)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
   Dana Farber Canc Inst, Boston, MA 02115 USA.
   NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1198
EP A1198
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202795
ER

PT J
AU Chen, PL
   Hutter, D
   Barnes, J
   Liu, YS
AF Chen, PL
   Hutter, D
   Barnes, J
   Liu, YS
TI The N-terminal basic motif of MAP kinase phosphatase-2 (MKP-2) mediates
   its catalytic activation by ERK and JNK MAP kinases
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, NIH, LBC, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1170
EP A1170
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202634
ER

PT J
AU Chen, SY
   Simons, SS
AF Chen, SY
   Simons, SS
TI E1A and E1A-associated proteins modulate GR-induced gene transactivation
   properties.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A908
EP A908
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201119
ER

PT J
AU Chen, WJ
   Frank, M
   Jin, WW
   Wahl, SM
AF Chen, WJ
   Frank, M
   Jin, WW
   Wahl, SM
TI Lethal effect of anti-CD3 antibody in mice lacking TGF-beta 1
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDCR, NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1045
EP A1045
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201919
ER

PT J
AU Chitnis, AB
   Jiang, D
   Kim, CH
AF Chitnis, AB
   Jiang, D
   Kim, CH
TI Losing your head over Notch and Wnt signaling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1071
EP A1071
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202070
ER

PT J
AU Cho-Chung, YS
   Cho, YS
   Kim, MK
   Becker, KG
   Cheadle, C
AF Cho-Chung, YS
   Cho, YS
   Kim, MK
   Becker, KG
   Cheadle, C
TI Molecular targets of cAMP signaling identified by DNA microarray
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1081
EP A1081
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202130
ER

PT J
AU Cohen, DM
   Quast, MJ
   Wei, JN
   Gao, XL
   Smith, EO
   Sokoloff, L
AF Cohen, DM
   Quast, MJ
   Wei, JN
   Gao, XL
   Smith, EO
   Sokoloff, L
TI Ten minutes suffices to estimate rates of cerebral glucose metabolism in
   rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Baylor Coll Med, Houston, TX 77030 USA.
   Univ Texas, Med Branch, Galveston, TX 77550 USA.
   Univ Houston, Houston, TX 77004 USA.
   NIH, NIMH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A752
EP A752
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200221
ER

PT J
AU Colden-Stanfield, M
   Ford, B
AF Colden-Stanfield, M
   Ford, B
TI Clustered very late activation antigen-4 (VLA-4) integrins enhance IRK1
   and GIRK1 K+ channel expression in human THP-1 monocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Morehouse Sch Med, Atlanta, GA 30310 USA.
   NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A843
EP A843
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200748
ER

PT J
AU Dai, D
AF Dai, D
TI Cardiovascular effects of polymorphic human CYP2C8s and the metabolism
   of arachidonic acid.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, LPC, Res Triangle Pk, NC 27709 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A918
EP A918
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201176
ER

PT J
AU Danilova, RA
   Fedorova, IM
AF Danilova, RA
   Fedorova, IM
TI The effect of active immunization against cholecystokinine (30-33) on
   rats behavior
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Moscow State Univ, Dept Biol, Moscow 117799, Russia.
   NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A913
EP A913
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201149
ER

PT J
AU Davis, SM
   Clay, TE
   Smyth, M
   Arviso, V
   Rock, BH
   Brice, R
   Stewart, D
   Altaha, J
   Flint-Wagner, HG
   Reed, J
   Metcalfe, L
   Stone, E
AF Davis, SM
   Clay, TE
   Smyth, M
   Arviso, V
   Rock, BH
   Brice, R
   Stewart, D
   Altaha, J
   Flint-Wagner, HG
   Reed, J
   Metcalfe, L
   Stone, E
TI School-based interventions to promote healthful eating and physical
   activity in American Indian schoolchildren: Pathways a multi-site study
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ New Mexico, Albuquerque, NM 87131 USA.
   Univ Minnesota, Minneapolis, MN 55454 USA.
   Univ N Carolina, Chapel Hill, NC 27599 USA.
   Johns Hopkins Univ, Baltimore, MD 21205 USA.
   Univ Arizona, Tucson, AZ 85721 USA.
   NIH, NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1091
EP A1091
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202185
ER

PT J
AU Dimitrova, MN
   Ginsburg, A
AF Dimitrova, MN
   Ginsburg, A
TI Mg(II)-phosphoenolpyruvate binding to enzyme I of the E. coli PTS
   strongly promotes protein dimerization and interdomain interactions
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A893
EP A893
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201034
ER

PT J
AU Dmitrieva, N
   Michea, L
   Burg, M
AF Dmitrieva, N
   Michea, L
   Burg, M
TI p53 tumor suppressor protein protects renal inner medullary cells from
   hypertonic stress by restricting DNA replication.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A850
EP A850
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200788
ER

PT J
AU Dubois, SP
   Waldmann, TA
   Tagaya, Y
AF Dubois, SP
   Waldmann, TA
   Tagaya, Y
TI Biochemical analysis of the quiescence inducing activity of IL-15 on CD4
   T cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1055
EP A1055
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201978
ER

PT J
AU Fedorova, IM
   Basile, AS
AF Fedorova, IM
   Basile, AS
TI Characterization of the cannabimimetic actions of oleamide, an
   endogenous hypnotic
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, NIH, Bioorgan Chem Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A911
EP A911
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201138
ER

PT J
AU Ferreira, PA
   Cai, YF
   Singh, BB
AF Ferreira, PA
   Cai, YF
   Singh, BB
TI The Ran-binding protein 2, a signal integrator of nucleocytoplasmic
   trafficking pathways.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   NIH, Bethesda, MD 20892 USA.
RI Ferreira, Paulo/A-3893-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A905
EP A905
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201102
ER

PT J
AU Friso, S
   Jacques, PF
   Wilson, PWF
   Rosenberg, IH
   Selhub, J
AF Friso, S
   Jacques, PF
   Wilson, PWF
   Rosenberg, IH
   Selhub, J
TI Low plasma pyridoxal-5 '-phosphate levels are associated with elevation
   of the inflammation marker, C-reactive protein
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Tufts Univ, JM USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   NHLBI, Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A963
EP A963
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201436
ER

PT J
AU Gelderman, MP
   Oliver, KL
   Cameron, TI
   Garger, SJ
   Holtz, RB
   Brady, RO
AF Gelderman, MP
   Oliver, KL
   Cameron, TI
   Garger, SJ
   Holtz, RB
   Brady, RO
TI Humoral immune responses to alpha-galactosidase A in the murine analog
   of Fabry disease
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Large Scale Biol Corp, Vacaville, CA 96688 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A871
EP A871
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200905
ER

PT J
AU Graham, LJ
   Veri, MC
   DeBell, KE
   Rawat, R
   Jen, S
   Bonvini, E
   Rellahan, BL
AF Graham, LJ
   Veri, MC
   DeBell, KE
   Rawat, R
   Jen, S
   Bonvini, E
   Rellahan, BL
TI 70Z/3 Cbl promotes PLCgamma1 phosphorylation in T lymphocytes by a
   distinct pathway
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1042
EP A1042
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201902
ER

PT J
AU Grammer, AC
   Heaney, J
   Lipsky, PE
AF Grammer, AC
   Heaney, J
   Lipsky, PE
TI Relationship between the degree of CD40 receptor occupancy on human B
   cells and patterns of MAPK activation.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1038
EP A1038
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201876
ER

PT J
AU Graver, B
   Buckley, D
   Buckley, A
   Cacini, W
AF Graver, B
   Buckley, D
   Buckley, A
   Cacini, W
TI Ventricular choline transport: A possible role for rOCT2 in choroid
   plexus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A854
EP A854
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200811
ER

PT J
AU Guo, LY
   Hu-Li, J
   Zhu, JF
   Pannetier, C
   Watson, C
   McKenzie, GJ
   McKenzie, ANJ
   Paul, WE
AF Guo, LY
   Hu-Li, J
   Zhu, JF
   Pannetier, C
   Watson, C
   McKenzie, GJ
   McKenzie, ANJ
   Paul, WE
TI Disruption of the IL-13 gene impairs production of IL-4 specified by the
   linked allele
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Bethesda, MD 20892 USA.
   Lorantis, Cambridge, England.
   MRC, Mol Biol Lab, Cambridge CB2 2QH, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1057
EP A1057
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201986
ER

PT J
AU Hagaman, DD
   Okayama, Y
   Gilfillan, AM
   Metcalfe, DD
AF Hagaman, DD
   Okayama, Y
   Gilfillan, AM
   Metcalfe, DD
TI The production of IL-1ra by cultured human mast cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1020
EP A1020
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201769
ER

PT J
AU Han, YH
   Pritchard, JB
AF Han, YH
   Pritchard, JB
TI Induction of verapamil transporters in cultured human retinal pigment
   epithelial (RPE) cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A853
EP A853
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200804
ER

PT J
AU Harvey, JJ
   Knutson, JR
   Han, MK
AF Harvey, JJ
   Knutson, JR
   Han, MK
TI Fluorescence resonance energy transfer distance determination between
   single tryptophans in HIV-1 integrase and a labeled LTR oligomer
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Georgetown Univ, Washington, DC 20007 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A906
EP A906
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201110
ER

PT J
AU Hatfield, DL
   Martin-Romero, FJ
   Kryukov, GV
   Lee, BJ
   Gladyshev, VN
AF Hatfield, DL
   Martin-Romero, FJ
   Kryukov, GV
   Lee, BJ
   Gladyshev, VN
TI Selenium metabolism in Drosophila: Aging and selenoprotein expression.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
   Univ Nebraska, Lincoln, NE 68588 USA.
   IMBG, Seoul 151742, South Korea.
RI Gladyshev, Vadim/A-9894-2013
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A952
EP A952
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201377
ER

PT J
AU Hawkins, ME
   Balis, FM
AF Hawkins, ME
   Balis, FM
TI Fluorescent pteridine nucleoside analogs: A window on DNA interactions
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Pediat Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A878
EP A878
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200945
ER

PT J
AU Hayashi, N
   Liu, DC
   Hu-Li, J
   Ben-Sasson, SZ
   Paul, WE
AF Hayashi, N
   Liu, DC
   Hu-Li, J
   Ben-Sasson, SZ
   Paul, WE
TI Memory T cells can be eliminated by intravenous challenge with antigen
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Immunol Lab, Bethesda, MD 20892 USA.
   Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1197
EP A1197
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202791
ER

PT J
AU Hendrix, MJC
   Seftor, EA
   Gardner, LMG
   Trent, JM
   Meltzer, PS
   Seftor, REB
AF Hendrix, MJC
   Seftor, EA
   Gardner, LMG
   Trent, JM
   Meltzer, PS
   Seftor, REB
TI Expression of select-endothelial-specific genes by aggressive human
   melanoma cells: Putative role of VE-cadherin (CD144) in vasculogenic
   mimicry
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NHGRI, Canc Genet Branch, Bethesda, MD 20892 USA.
   Univ Iowa, Iowa City, IA 52242 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A743
EP A743
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200170
ER

PT J
AU Hoffmann, SC
   Stanley, EM
   Cox, ED
   Craighead, N
   Perfetto, SP
   Harlan, DM
   Kirk, AD
   Blair, PJ
AF Hoffmann, SC
   Stanley, EM
   Cox, ED
   Craighead, N
   Perfetto, SP
   Harlan, DM
   Kirk, AD
   Blair, PJ
TI The polymorphism at-330 in the interleukin-2 gene results in a
   significant increase in IL-2 protein following co-stimulation of
   peripheral blood lymphocytes with anti-CD3/CD28.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, Bethesda, MD 20889 USA.
   Walter Reed Army Med Ctr, Bethesda, MD 20889 USA.
   Naval Med Res Ctr, Bethesda, MD 20889 USA.
   Vaccine Res Ctr, NIH, Bethesda, MD 20889 USA.
RI Kirk, Allan/B-6905-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1055
EP A1055
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201975
ER

PT J
AU Hogan, MC
   Stary, CM
   Balaban, RS
   Combs, CA
AF Hogan, MC
   Stary, CM
   Balaban, RS
   Combs, CA
TI NADH fluorescence at the onset of steady-state contractions in isolated
   single skeletal muscle fibers
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   NIH, NHLBI, LCE, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A815
EP A815
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200588
ER

PT J
AU Hu, JX
   Goldsmith, PK
   Spiegel, AM
AF Hu, JX
   Goldsmith, PK
   Spiegel, AM
TI Structural and functional studies of the extracellular domain of the
   human Ca2+receptor
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Mol Pathophysiol Sect, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1113
EP A1113
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202306
ER

PT J
AU Huang, JQ
   Murray, R
   Muegge, K
AF Huang, JQ
   Murray, R
   Muegge, K
TI IL-7 controls accessibility for V(D)J recombination via histone
   acetylation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, FCRDC, Frederick, MD 21702 USA.
   DNAX Res Inst Mol & Cellular Biol Inc, Paolo Alto, CA USA.
   SAIC, Intramural Res Support Program, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1229
EP A1229
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202975
ER

PT J
AU Huang, X
   Herreman, K
   Blackman, M
   Pabst, K
   Harman, SM
   Caballero, B
AF Huang, X
   Herreman, K
   Blackman, M
   Pabst, K
   Harman, SM
   Caballero, B
TI Effects of hormone replacement on IGF-1 levels and protein synthesis in
   the elderly
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Johns Hopkins Univ, Ctr Human Nutr, Baltimore, MD 21205 USA.
   Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA.
   NIA, Gerontol Res Ctr, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A758
EP A758
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200254
ER

PT J
AU Huhn, JS
   Wei, L
   Mory, K
   Pathak, HB
   Sosnovtsev, SV
   Green, KY
   Cameron, CE
AF Huhn, JS
   Wei, L
   Mory, K
   Pathak, HB
   Sosnovtsev, SV
   Green, KY
   Cameron, CE
TI The proteinase-polymerase precursor protein as the active form of the
   feline calicivirus RNA-dependent RNA polymerase
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Penn State Univ, University Pk, PA 16802 USA.
   NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A907
EP A907
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201113
ER

PT J
AU Jin, WW
   Frank, M
   Wahl, SM
   Chen, WJ
AF Jin, WW
   Frank, M
   Wahl, SM
   Chen, WJ
TI Suppression of SCW-induced arthritis by systemic delivery of apoptotic
   thymocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1216
EP A1216
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202897
ER

PT J
AU Kalmbach, R
   Jacques, PF
   Bagley, PJ
   Russo, G
   Wilson, PWF
   Rosenberg, IH
AF Kalmbach, R
   Jacques, PF
   Bagley, PJ
   Russo, G
   Wilson, PWF
   Rosenberg, IH
TI Folate status and methylenetetrahydrofolate reductase (MTHFR) C677T
   genotype influence the relation between riboflavin status and total
   plasma homocysteine (tHcy) concentrations
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Tufts Univ, JM USDA HNRCA, Boston, MA 02111 USA.
   NHLBI, Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A956
EP A956
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201396
ER

PT J
AU Katz, JL
   Agoston, GE
   Alling, KL
   Kline, RH
   Forster, MJ
   Woolverton, WL
   Izenwasser, S
   Kopajtic, TA
   Newman, AH
AF Katz, JL
   Agoston, GE
   Alling, KL
   Kline, RH
   Forster, MJ
   Woolverton, WL
   Izenwasser, S
   Kopajtic, TA
   Newman, AH
TI Dopamine transporter binding without cocaine-like behavioral effects:
   Synthesis and evaluation of benztropine analogs alone and in combination
   with cocaine
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Natl Inst Drug Abuse, Baltimore, MD 21224 USA.
   Univ N Texas, Hlth Sci Ctr, Denton, TX 76203 USA.
   Univ Mississippi, University, MS 38677 USA.
   Univ Miami, Coral Gables, FL 33124 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A909
EP A909
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201123
ER

PT J
AU Keane-Myers, AM
   Urban, J
   Chan, CC
   Schopf, L
AF Keane-Myers, AM
   Urban, J
   Chan, CC
   Schopf, L
TI Helminth infection potentiates allergic ocular inflammation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Lab Allerg Dis, Rockville, MD 20852 USA.
   NIAID, Rockville, MD 20852 USA.
   USDA, Washington, DC 20250 USA.
   NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1015
EP A1015
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201744
ER

PT J
AU Kelly, AE
   Noben-Trauth, N
   Melo, M
   Smith, E
   Haudenschild, C
   Keegan, AD
AF Kelly, AE
   Noben-Trauth, N
   Melo, M
   Smith, E
   Haudenschild, C
   Keegan, AD
TI Complex role for the IL-4R alpha in a murine model of asthma.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Amer Red Cross, Rockville, MD 20855 USA.
   NIAID, Rockville, MD 20852 USA.
   NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1017
EP A1017
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201756
ER

PT J
AU Kennedy, MC
   Stowers, AW
   Chen, LH
   Zhang, YL
   Meade, H
   Kaslow, DC
   Hall, BF
   Miller, L
   Long, CA
AF Kennedy, MC
   Stowers, AW
   Chen, LH
   Zhang, YL
   Meade, H
   Kaslow, DC
   Hall, BF
   Miller, L
   Long, CA
TI Antibody avidity is an effective predictor of malaria vaccine efficacy
   in Aotus monkeys.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Parasit Dis Lab, Malaria Vaccine Dev Unit, Rockville, MD USA.
   Genzyme Transgen Corp, Farmingham, MA USA.
   NIAID, Div Microbiol & Infect Dis, Int Programs Branch, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1190
EP A1190
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202748
ER

PT J
AU Khaled, A
   Kim, K
   Muegge, K
   Thompson, C
   Fliegel, L
   Durum, SK
AF Khaled, A
   Kim, K
   Muegge, K
   Thompson, C
   Fliegel, L
   Durum, SK
TI Trophic factor withdrawal induces a novel pathway: p38 MAPK activates
   NHE1 resulting in intracellular alkalinization, an early step in
   apoptosis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
   SAIC, FCRDC, Frederick, MD 21702 USA.
   Univ Penn, Philadelphia, PA 19104 USA.
   Univ Alberta, Edmonton, AB, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1046
EP A1046
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201923
ER

PT J
AU Khan, QA
   Anderson, LM
AF Khan, QA
   Anderson, LM
TI Reactive metabolite of a tobacco smoke carcinogen evades p53-mediated
   cellular defense mechanism of G1 arrest in type II lung cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Natl Canc Inst, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1227
EP A1227
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202962
ER

PT J
AU Kim, K
   Khaled, A
   Muegge, K
   Durum, SK
AF Kim, K
   Khaled, A
   Muegge, K
   Durum, SK
TI Characterization of an IL-7-dependent thymocyte line: D1
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Sahmyook Univ, Seoul 139742, South Korea.
   NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1194
EP A1194
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202771
ER

PT J
AU Kramer, PM
   Gunning, WT
   Luber, RA
   Steele, VE
   Pereira, MA
AF Kramer, PM
   Gunning, WT
   Luber, RA
   Steele, VE
   Pereira, MA
TI Prevention of colon and lung tumors in mice by budesonide, dexamethasone
   and piroxicam.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Med Coll Ohio, Toledo, OH 43614 USA.
   NCI, Rockville, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A914
EP A914
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201152
ER

PT J
AU Kumaraswamy, E
   Korotkov, KV
   Hu, YJ
   Berry, MJ
   Diamond, AM
   Hatfield, DL
   Gladyshev, VN
AF Kumaraswamy, E
   Korotkov, KV
   Hu, YJ
   Berry, MJ
   Diamond, AM
   Hatfield, DL
   Gladyshev, VN
TI Implication of the 15 kDa selenoprotein in cancer etiology.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
   Univ Nebraska, Lincoln, NE 68588 USA.
   Univ Illinois, Chicago, IL 60612 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
RI Gladyshev, Vadim/A-9894-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A952
EP A952
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201374
ER

PT J
AU Landon, LA
   Peletskaya, EN
   Glinskii, VV
   Deutscher, SL
AF Landon, LA
   Peletskaya, EN
   Glinskii, VV
   Deutscher, SL
TI Targeting of Thomson-Friedenreich antigen (T-Ag) on cancer cells by
   peptides.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Missouri, Dept Biochem, Columbia, MO 65212 USA.
   NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1208
EP A1208
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202854
ER

PT J
AU Lapointe, R
   Housseau, F
   Topalian, SL
   Hwu, P
AF Lapointe, R
   Housseau, F
   Topalian, SL
   Hwu, P
TI A novel method to generate tumor antigen-reactive T-cells using CD40
   activated B-cells pulsed with cell lysates
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1206
EP A1206
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202838
ER

PT J
AU Lee, BJ
   Kim, M
   Park, J
   Sargent, TD
   Hatfield, DL
AF Lee, BJ
   Kim, M
   Park, J
   Sargent, TD
   Hatfield, DL
TI Cloning and characterization of a novel zinc finger protein, FAX-ZFP in
   Xenopus laevis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea.
   NICHHD, NIH, Bethesda, MD 20892 USA.
   NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A901
EP A901
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201078
ER

PT J
AU Lee, JK
   Back, TC
   Komschlies, KL
   Wiltrout, RH
AF Lee, JK
   Back, TC
   Komschlies, KL
   Wiltrout, RH
TI Hematopoietic switch from lymphoid to granulocytic development in 3LL
   tumor-bearing mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1204
EP A1204
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202826
ER

PT J
AU Lee, SP
   Fuior, E
   Lewis, M
   Han, MK
AF Lee, SP
   Fuior, E
   Lewis, M
   Han, MK
TI Analytical sedimentation studies of translin-DNA interactions
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Georgetown Univ, Washington, DC 20007 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A877
EP A877
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200940
ER

PT J
AU Leiderman, YI
   Long, CA
AF Leiderman, YI
   Long, CA
TI Dendritic cells in the induction of immunity to erythrocytic stages of
   Plasmodium yoelii malaria
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1191
EP A1191
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202755
ER

PT J
AU Li, YF
   Hess, S
   Pannell, LK
   Tabor, CW
   Tabor, H
AF Li, YF
   Hess, S
   Pannell, LK
   Tabor, CW
   Tabor, H
TI Purification, characterization, and in vivo modification of
   S-adenosylmethionine decarboxylases
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
RI Hess, Sonja/K-4842-2013
OI Hess, Sonja/0000-0002-5904-9816
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A889
EP A889
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201010
ER

PT J
AU Liu, KB
   Li, Y
   Prabhu, V
   Young, L
   Becker, KG
   Munson, P
   Weng, NP
AF Liu, KB
   Li, Y
   Prabhu, V
   Young, L
   Becker, KG
   Munson, P
   Weng, NP
TI Augmentation in expression of activation-induced genes differentiates
   memory from naive CD4+T cells and is a molecular mechanism of enhanced
   cellular response of memory CD4+T cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, NIH, Baltimore, MD 21224 USA.
   NIA, Immunol Lab, NIH, Baltimore, MD 21224 USA.
   NIH, Ctr Informat Technol, Bethesda, MD 20892 USA.
   NIA, Microarray Unit, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1196
EP A1196
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202780
ER

PT J
AU Makrigiannis, AP
   Pau, AT
   Saleh, A
   Winkler-Pickett, R
   Ortaldo, JR
   Anderson, SK
AF Makrigiannis, AP
   Pau, AT
   Saleh, A
   Winkler-Pickett, R
   Ortaldo, JR
   Anderson, SK
TI Class I MHC binding characteristics of the 129/J-Ly49 repertoire
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 SAIC Frederick, Frederick, MD 21702 USA.
   NCI Frederick, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1032
EP A1032
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201844
ER

PT J
AU Matsushita, K
   Margalis, I
   Onda, M
   Fitzgerald, DJP
   Pastan, I
   Kreitman, RJ
AF Matsushita, K
   Margalis, I
   Onda, M
   Fitzgerald, DJP
   Pastan, I
   Kreitman, RJ
TI Elevation of proinflammatory cytokines IL-6, IL-8 and TNF alpha in the
   plasma of patients treated with immunotoxin RFB4(dsFv)-PE38 (BL22)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1199
EP A1199
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202799
ER

PT J
AU Matsushita, K
   Margalis, I
   Onda, M
   FitzGerald, DJP
   Pastan, I
   Kreitman, RJ
AF Matsushita, K
   Margalis, I
   Onda, M
   FitzGerald, DJP
   Pastan, I
   Kreitman, RJ
TI Recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) can stimulate the
   production of proinflammatory cytokines IL-6, IL-8 and TNF alpha from
   normal peripheral blood mononuclear cells.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1198
EP A1198
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202792
ER

PT J
AU McBride, PE
   Tobin, BW
   Stone, EJ
   Van Horn, L
AF McBride, PE
   Tobin, BW
   Stone, EJ
   Van Horn, L
TI Translating nutrition trials and guidelines into medical education and
   practice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Wisconsin, Madison, WI 53792 USA.
   Mercer Univ, Sch Med, Macon, GA 31207 USA.
   NHLBI, Bethesda, MD 20892 USA.
   Northwestern Univ, Sch Med, Chicago, IL 60611 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1095
EP A1095
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202204
ER

PT J
AU McHugh, RS
   Thornton, A
   Shevach, EM
AF McHugh, RS
   Thornton, A
   Shevach, EM
TI Mechanism of CD4+CD25+T cell immunoregulatory activity in vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1219
EP A1219
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202919
ER

PT J
AU McIntire, JJ
   Umetsu, SE
   Yeung, VP
   Hansen, G
   Potter, M
   Barsh, GS
   Umetsu, DT
   DeKruyff, RH
AF McIntire, JJ
   Umetsu, SE
   Yeung, VP
   Hansen, G
   Potter, M
   Barsh, GS
   Umetsu, DT
   DeKruyff, RH
TI Tapr, a regulatory locus on murine chromosome 11 associated with high
   IL-4 expression and airway hyperreactivity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Stanford Univ, Palo Alto, CA 94304 USA.
   NIH, NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1017
EP A1017
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201754
ER

PT J
AU McKarns, SC
   Letterio, JJ
   Kaminski, NE
AF McKarns, SC
   Letterio, JJ
   Kaminski, NE
TI TGF-1/SMAD signaling-dependent inhibition of interleukin-2 in
   a-CD3+a-CD28-activated T cells: Evidence for a regulatory role by ERK
   MAP kinase pathways
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Michigan State Univ, E Lansing, MI 48824 USA.
   NCI, Lab Cell Reg & Carcinog, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1054
EP A1054
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201971
ER

PT J
AU Mei, JM
   Borchert, GL
   Donald, SP
   Phang, JM
AF Mei, JM
   Borchert, GL
   Donald, SP
   Phang, JM
TI Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of
   beta-catenin from membrane bound E-cadherin and formation of the nuclear
   beta-catenin/LEF-1 complex
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A933
EP A933
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201264
ER

PT J
AU Melo, ME
   El-Amine, M
   Agarwal, R
   Kang, YB
   Caspi, R
   Scott, DW
AF Melo, ME
   El-Amine, M
   Agarwal, R
   Kang, YB
   Caspi, R
   Scott, DW
TI Induction of tolerance and treatment of autoimmne diseases by expression
   of tolerogenic IgG-fusion proteins in B cells.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Amer Red Cross, Jerome H Holland Lab, Rockville, MD 20855 USA.
   NEI, NIH, Bethesda, MD 20892 USA.
   Univ Iowa, Coll Med, Iowa City, IA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1217
EP A1217
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202908
ER

PT J
AU Mendel, IM
AF Mendel, IM
TI Requirement for IL-4 for the induction of IL-10 producing regulatory T
   cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1026
EP A1026
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201806
ER

PT J
AU Moskovitz, J
   Bar-Noy, S
   Williams, WM
   Berlett, BS
   Stadtman, ER
AF Moskovitz, J
   Bar-Noy, S
   Williams, WM
   Berlett, BS
   Stadtman, ER
TI Characterization of a "knock-out" mouse of peptide-methionine sulfoxide
   reductase (MsrA).
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A890
EP A890
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201014
ER

PT J
AU Moustafa, ME
   Carlson, BA
   Kryukov, GV
   Sun, QA
   Diamond, AM
   Lee, BJ
   Gladyshev, VN
   Hatfield, DL
AF Moustafa, ME
   Carlson, BA
   Kryukov, GV
   Sun, QA
   Diamond, AM
   Lee, BJ
   Gladyshev, VN
   Hatfield, DL
TI Transgenic mice expressing I(6)A mutant Sec tRNA ((Ser)Sec): Selective
   inhibition of Sec tRNA ((Ser)Sec) maturation and selenoprotein
   synthesis.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
   Univ Nebraska, Lincoln, NE 68588 USA.
   Univ Illinois, Chicago, IL 60612 USA.
   Seoul Natl Univ, Seoul 151742, South Korea.
RI Gladyshev, Vadim/A-9894-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A953
EP A953
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201378
ER

PT J
AU Nagababu, E
   Rifkind, JM
AF Nagababu, E
   Rifkind, JM
TI %PDF-1.3
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A875
EP A875
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200928
ER

PT J
AU Park, SH
AF Park, SH
TI A sequence-specific enhancer binding protein is responsible for the
   differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric
   cancer cell lines: Implication for the loss of TGF-[beta] type II
   receptor expression
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A881
EP A881
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200966
ER

PT J
AU Patterson, B
   Veillon, CC
   Taylor, P
   Patterson, K
   Levander, OA
AF Patterson, B
   Veillon, CC
   Taylor, P
   Patterson, K
   Levander, OA
TI Selenium metabolism in humans differs by gender: Results from a stable
   isotope tracer study
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Bethesda, MD 20892 USA.
   USDA, Beltsville, MD 20705 USA.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A969
EP A969
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201472
ER

PT J
AU Patterson, RM
   Stachelwitz, R
   Way, ML
   Germolec, D
AF Patterson, RM
   Stachelwitz, R
   Way, ML
   Germolec, D
TI Induction of apoptosis in TCDD-induced endotoxin hypersensitivity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
   Inotek Inc, Cincinnati, OH 45219 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1045
EP A1045
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201917
ER

PT J
AU Pearson, TA
   Stone, EJ
   Krebs, N
   Grundy, SM
AF Pearson, TA
   Stone, EJ
   Krebs, N
   Grundy, SM
TI Improving physicians' knowledge and practice in human nutrition: Goals
   and objectives of the Nutrition Academic Award Program
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Rochester, Sch Med, Rochester, NY 14511 USA.
   NHLBI, Bethesda, MD 20892 USA.
   Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA.
   Univ Texas, SW Med Ctr, Dallas, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1095
EP A1095
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202203
ER

PT J
AU Polson, JB
   Johnson-Mills, K
   Amin, J
   Arauz, E
   Krzanowski, JJ
AF Polson, JB
   Johnson-Mills, K
   Amin, J
   Arauz, E
   Krzanowski, JJ
TI Expression of PDE3A and PDE3B genes in proliferating human coronary
   artery smooth muscle cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Tampa, FL 33612 USA.
   NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A923
EP A923
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201206
ER

PT J
AU Qin, SF
   Chock, PB
AF Qin, SF
   Chock, PB
TI Bruton's tyrosine kinase is essential for hydrogen peroxide-induced
   calcium signaling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A906
EP A906
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201106
ER

PT J
AU Rabinovitz, M
AF Rabinovitz, M
TI Uncharged tRNA-phosphofructokinase interaction in amino acid deficiency
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20814 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A989
EP A989
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201590
ER

PT J
AU Schnermann, J
   Sun, DQ
   Samuelson, L
   Briggs, J
AF Schnermann, J
   Sun, DQ
   Samuelson, L
   Briggs, J
TI Generation of mice with targeted disruption of the adenosine 1 receptor
   (A1R) gene
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Univ Michigan, Dept Physiol, Ann Arbor, MI 48109 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A833
EP A833
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200689
ER

PT J
AU Sereti, I
   Martinez-Wilson, H
   Metcalf, JA
   Lane, HC
AF Sereti, I
   Martinez-Wilson, H
   Metcalf, JA
   Lane, HC
TI IL-2 administration to HIV infected patients leads to expansion of the
   naive pool of CD4(+) T lymphocytes in association with increased
   expression of the alpha chain but not the beta chain of the IL-2
   receptor
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1055
EP A1055
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201977
ER

PT J
AU Shevtsov, S
   Petrotshenko, JV
   Pedersen, LC
   Negishi, M
AF Shevtsov, S
   Petrotshenko, JV
   Pedersen, LC
   Negishi, M
TI Crystallographic analysis of the inhibition by polychlorinated
   biphenyl's (PCBs) on the human and mouse estrogen sulfotransferases.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1159
EP A1159
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202574
ER

PT J
AU Shimizu, C
   Lee, YC
   Fuda, H
   Strott, CA
AF Shimizu, C
   Lee, YC
   Fuda, H
   Strott, CA
TI Promoter analysis of human PAPS synthase (PAPSS) 1 and 2
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A882
EP A882
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200969
ER

PT J
AU Sinha, M
   Mackall, CL
AF Sinha, M
   Mackall, CL
TI IL7 worsens graft verses host disease following allogeneic bone marrow
   transplantation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Dept Pediat Oncol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A749
EP A749
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200203
ER

PT J
AU Sloan, JM
   Kershaw, M
   Lapointe, R
   Robbins, P
   Restifo, N
   Hwu, P
AF Sloan, JM
   Kershaw, M
   Lapointe, R
   Robbins, P
   Restifo, N
   Hwu, P
TI MHC class I and class II presentation of tumor antigen in retrovirally
   and adenovirally transduced dendritic cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Surg Branch, NIH, Bethesda, MD 20892 USA.
RI Restifo, Nicholas/A-5713-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1202
EP A1202
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202819
ER

PT J
AU Soldatov, NM
   Carlson, O
   Zhang, ZG
   Abernethy, DR
AF Soldatov, NM
   Carlson, O
   Zhang, ZG
   Abernethy, DR
TI Conditional age-dependent switch of Ca2+ channel alpha(1C) subunit
   splice variants to exon 21-isoform in human aortic cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Baltimore, MD 21224 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A927
EP A927
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201230
ER

PT J
AU Someya, A
   Sata, M
   Takeda, K
   Pacheco-Rodriguez, G
   Ferrans, VJ
   Moss, J
   Vaughan, M
AF Someya, A
   Sata, M
   Takeda, K
   Pacheco-Rodriguez, G
   Ferrans, VJ
   Moss, J
   Vaughan, M
TI A novel Sec7 domain guanine nucleotide-exchange protein (GEP) for
   ADP-ribosylation factors (ARFs)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1175
EP A1175
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202665
ER

PT J
AU Steeg, PS
AF Steeg, PS
TI Metastasis suppressor genes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A744
EP A744
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200174
ER

PT J
AU Stetler-Stevenson, WG
AF Stetler-Stevenson, WG
TI Matrix metalloproteinases and inhibitors: Changing roles in tumor
   progression
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, DCS, NIH, Bethesda, MD 20892 USA.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A744
EP A744
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200177
ER

PT J
AU Stewart, DM
   Tian, L
   Nelson, DL
AF Stewart, DM
   Tian, L
   Nelson, DL
TI Evidence for interaction of WASP and WIP with Huntington interacting
   protein (HYPA)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1015
EP A1015
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201740
ER

PT J
AU Stewart, DM
   Tian, L
   Nelson, DL
AF Stewart, DM
   Tian, L
   Nelson, DL
TI A case of X-linked agammaglobulinemia diagnosed in adulthood
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1013
EP A1013
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201728
ER

PT J
AU Storey, N
   O'Bryan, JP
   Armstrong, DL
AF Storey, N
   O'Bryan, JP
   Armstrong, DL
TI Potassium channel inhibition by G-protein coupled receptors through
   Rho-dependent signaling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Natl Inst Environm Hlth, Res Triangle Pk, NC 27510 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A842
EP A842
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200745
ER

PT J
AU Subar, AF
   Thompson, FE
   Midthune, D
   Rosenfeld, S
   Hurwitz, P
   McNutt, S
   McIntosh, A
   Kipnis, V
AF Subar, AF
   Thompson, FE
   Midthune, D
   Rosenfeld, S
   Hurwitz, P
   McNutt, S
   McIntosh, A
   Kipnis, V
TI Comparative validation of the Block, Willett, and National Cancer
   Institute (NCI) Food Freqency Questionnaires (FFQs).
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   Westat Inc, Rockville, MD USA.
NR 0
TC 1
Z9 1
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A734
EP A734
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200120
ER

PT J
AU Szczepanik, MB
   Pande, P
   Laux, W
   Debrabant, A
   Dwyer, D
   Johnson, RA
AF Szczepanik, MB
   Pande, P
   Laux, W
   Debrabant, A
   Dwyer, D
   Johnson, RA
TI Synthesis and use of chemical probes for structural studies of
   Leishmania donovani 3'-nucleotidase
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 SUNY Stony Brook, Hlth Sci Ctr, Stony Brook, NY 11794 USA.
   NIH, NIAID, Cell Biol Sect, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1159
EP A1159
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202573
ER

PT J
AU Szeder, V
   Ren, ZG
   Sieber-Blum, M
   Tessarollo, L
   Grim, M
AF Szeder, V
   Ren, ZG
   Sieber-Blum, M
   Tessarollo, L
   Grim, M
TI TrkC signaling in Pacinian corpuscle development
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI USA.
   NCI, Frederick Canc Res & Dev Ctr, Neural Dev Grp, Frederick, MD USA.
   Charles Univ, Fac Med 1, Inst Anat, Prague, Czech Republic.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1232
EP A1232
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202989
ER

PT J
AU Taniuchi, H
   Shi, Y
   Perez-Lamboy, G
   Ferretti, JA
   Mack, JW
   Fisher, A
   Shah, M
   Schechter, AN
   Shiloach, Y
AF Taniuchi, H
   Shi, Y
   Perez-Lamboy, G
   Ferretti, JA
   Mack, JW
   Fisher, A
   Shah, M
   Schechter, AN
   Shiloach, Y
TI A study on the marked stability differences between yeast iso-2-and
   horse cytochromes c
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1174
EP A1174
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202658
ER

PT J
AU Tawab, AT
   Fields, J
   Chao, E
   Kurlander, RJ
AF Tawab, AT
   Fields, J
   Chao, E
   Kurlander, RJ
TI H2M3-restricted CD8 cells are readily generated in mice by recombinant
   listerial products and can potently contain Listeria monocytogenes
   infection in vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1008
EP A1008
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201700
ER

PT J
AU Terris, JM
   Knepper, MA
   Wade, JB
AF Terris, JM
   Knepper, MA
   Wade, JB
TI Localization and characterization of UT-A3 protein in the inner
   medullary collecting duct
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   NHLBI, NIH, Bethesda, MD 20892 USA.
   Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A852
EP A852
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200801
ER

PT J
AU Terris, JM
   Wang, XY
   Beutler, K
   Schooley, J
   Pamnani, MB
   Knepper, MA
AF Terris, JM
   Wang, XY
   Beutler, K
   Schooley, J
   Pamnani, MB
   Knepper, MA
TI Sodium transporter and sodium channel dysregulation in a model of
   high-renin hypertension: the two-kidney, one-clip Goldblatt rat
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A787
EP A787
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200429
ER

PT J
AU Tobin, B
   Smith, M
   Kushner, R
   Hark, L
   Eaton, C
AF Tobin, B
   Smith, M
   Kushner, R
   Hark, L
   Eaton, C
CA Nutr Acad Award Investigators
TI Nutrition curriculum guide for training physicians
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Mercer Univ, Sch Med, Macon, GA 31207 USA.
   Northwestern Univ, Sch Med, Chicago, IL USA.
   Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
   Brown Univ, Sch Med, Providence, RI 02912 USA.
   NHLBI, NIH, Bethesda, MD USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1095
EP A1095
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202206
ER

PT J
AU Tsai-Morris, CH
   Lei, S
   Jiang, Q
   Chang, TH
   Dufau, ML
AF Tsai-Morris, CH
   Lei, S
   Jiang, Q
   Chang, TH
   Dufau, ML
TI Genomic structure, phylogenetic analysis and functional studies of the
   mouse RNA helicase DDX25/GRTH gene
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NICHD, Sect Mol Endocrinol, Bethesda, MD 20892 USA.
   Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A880
EP A880
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200958
ER

PT J
AU Turni, LA
   Shaw, S
AF Turni, LA
   Shaw, S
TI Systematic assembly of biological information into a computer-based
   fabric of information: General strategy and use in publishing on the WWW
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NCI, Bethesda, MD 20894 USA.
   NIH, NCI, Expt Immunol Branch, Human Immunol Sect, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A748
EP A748
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200198
ER

PT J
AU Ueda, E
   Kurebayashi, S
   Koller, BH
   Patel, DD
   Jetten, AM
AF Ueda, E
   Kurebayashi, S
   Koller, BH
   Patel, DD
   Jetten, AM
TI Abnormal thymopoiesis and development of T cell lymphoma formation in
   ROR gamma-dificient mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, LPP, NIH, Res Triangle Pk, NC 27709 USA.
   Univ N Carolina, Dept Med & Mol Biol, Chapel Hill, NC USA.
   Duke Univ, Med Ctr, Dept Med & Immunol, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1193
EP A1193
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202765
ER

PT J
AU Vazquez-Maldonado, N
   Greenwell-Wild, T
   Wahl, SM
AF Vazquez-Maldonado, N
   Greenwell-Wild, T
   Wahl, SM
TI HIV-1 infection and signaling pathways in human macrophages
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1011
EP A1011
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201715
ER

PT J
AU Veri, MC
   DeBell, K
   Rawat, R
   Miscia, S
   Di Baldassarre, A
   Rellahan, B
   Graham, L
   Noviello, C
   Wange, R
   Bonvini, E
AF Veri, MC
   DeBell, K
   Rawat, R
   Miscia, S
   Di Baldassarre, A
   Rellahan, B
   Graham, L
   Noviello, C
   Wange, R
   Bonvini, E
TI Membrane microdomain-dependent regulation of phospholipase Cgamma-1
   activation in T lymphocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 US FDA, Immunol Lab, DMA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
   Ist Morfol Umana Normale, Chieti, Italy.
   NIA, Biol Chem Lab, GRC, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1042
EP A1042
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201903
ER

PT J
AU Vial, D
   Okazaki, H
   Siraganian, RP
AF Vial, D
   Okazaki, H
   Siraganian, RP
TI The NH2 terminal region of FAK reconstitutes high affinity IgE
   receptor-induced secretion in mast cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIDCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1018
EP A1018
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201762
ER

PT J
AU Wang, J
   Yang-Boja, E
   Ton, W
   Mieyal, J
   Fales, H
   Chock, B
AF Wang, J
   Yang-Boja, E
   Ton, W
   Mieyal, J
   Fales, H
   Chock, B
TI Actin deglutathionylation and polymerization
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NHLBI, Bethesda, MD USA.
   Case Western Reserve Univ, Cleveland, OH 44106 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A888
EP A888
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201002
ER

PT J
AU Wang, LW
   Yan, L
   McGuire, C
   Kozak, CA
   Kim, UJ
   Siciliano, M
   Weinshilboum, R
AF Wang, LW
   Yan, L
   McGuire, C
   Kozak, CA
   Kim, UJ
   Siciliano, M
   Weinshilboum, R
TI Mouse histamine N-methyltransferase: cDNA and gene cloning, expression
   and chromosomal localization
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Mayo Clin & Mayo Grad Sch Med, Rochester, MN 55905 USA.
   NIAID, NIH, Bethesda, MD 20892 USA.
   CALTECH, Pasadena, CA 91125 USA.
   Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A920
EP A920
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201190
ER

PT J
AU Wang, P
   Sun, SH
   Silver, PB
   Chan, CC
   Wiggert, B
   Agarwal, RK
   Caspi, RR
AF Wang, P
   Sun, SH
   Silver, PB
   Chan, CC
   Wiggert, B
   Agarwal, RK
   Caspi, RR
TI Methimazole inhibits experimental autoimmune uveoretinitis (EAU)
   inhibiting antigen priming
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NEI, Bethesda, MD 20892 USA.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1211
EP A1211
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454202871
ER

PT J
AU Wang, XY
   Masilamani, S
   Knepper, MA
AF Wang, XY
   Masilamani, S
   Knepper, MA
TI Decreased abundances of collecting duct area transporters (UTA1 and
   UTA3) with extracellular fluid volume expansion
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A852
EP A852
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200799
ER

PT J
AU Yang, TX
   Pasumarthy, A
   Briggs, JP
   Schnermann, JB
AF Yang, TX
   Pasumarthy, A
   Briggs, JP
   Schnermann, JB
TI Nitric oxide stimulates cyclooxgenase-2 expression in collecting duct
   cells through a cGMP-independent mechanism
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A832
EP A832
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454200685
ER

PT J
AU Zhang, J
   Billingsley, ML
   Kincaid, RL
   Siraganian, RP
AF Zhang, J
   Billingsley, ML
   Kincaid, RL
   Siraganian, RP
TI Phosphorylation of Syk activation loop tyrosines is essential for Syk
   function: An in vivo study using a specific anti-Syk activation loop
   phosphotyrosine antibody
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIDCR, Bethesda, MD 20892 USA.
   Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA.
NR 0
TC 3
Z9 3
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1020
EP A1020
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201773
ER

PT J
AU Zhou, YJ
   Changelian, PS
   O'Shea, JJ
AF Zhou, YJ
   Changelian, PS
   O'Shea, JJ
TI Unexpected effects of N-terminal mutations on catalytic activity of
   JAK3: Structural implication for Janus kinases
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMS, NIH, Bethesda, MD 20892 USA.
   Pfizer Inc, Cent Res, Dept Immunol, Groton, CT 06340 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1015
EP A1015
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201742
ER

PT J
AU Zhu, JF
   Guo, LY
   Watson, CJ
   Hu-Li, J
   Paul, WE
AF Zhu, JF
   Guo, LY
   Watson, CJ
   Hu-Li, J
   Paul, WE
TI Gfi-1 is an immediate-early gene induced by IL-4 in CD4+T cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 8
PY 2001
VL 15
IS 5
BP A1056
EP A1056
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410TA
UT WOS:000167454201985
ER

PT J
AU Bonnet-Gonnet, C
   Leikin, S
   Chi, S
   Rau, DC
   Parsegian, VA
AF Bonnet-Gonnet, C
   Leikin, S
   Chi, S
   Rau, DC
   Parsegian, VA
TI Measurement of forces between hydroxypropylcellulose polymers:
   Temperature favored assembly and salt exclusion
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID DNA DOUBLE HELICES; COLLAGEN TRIPLE HELICES; HYDRATION FORCES;
   AQUEOUS-SOLUTIONS; HYDROPHOBIC INTERACTIONS; COLLOIDAL INTERACTIONS;
   WATER; ENTHALPY; ENTROPY; (HYDROXYPROPYL)CELLULOSE
AB The thermodynamic forces between hydroxypropylcellulose (HPC) molecules at close separation have been measured using the osmotic stress method coupled with X-ray scattering. Two force regimes are apparent: a very short ranged, temperature insensitive force that dominates interactions within the last 2.5 Angstrom separation and a longer-ranged force that varies exponentially vs distance with a decay length of about 3-4 Angstrom. The longer-ranged force characteristics are strikingly similar to those found for many other macromolecules. We have previously argued that these characteristics are due to a hydration or water structuring force. The amplitude of the longer ranged force in these condensed arrays decreases linearly with temperature. The force switches from repulsive to attractive at similar to 40 degreesC, about the same temperature at which HPC precipitates from dilute solution. The entropy of the HPC condensed array, derived from the temperature dependence of the force, also varies exponentially vs spacing with a 3-4 Angstrom decay length. Measured forces are also surprisingly sensitive to added salt. Salt acts by its exclusion from the HPC phase. The salt concentration gradient within the space between polymers, inferred from the salt concentration dependence of the force curves, is itself apparently exponential with the about same 3-4 Angstrom decay length as the force and entropy.
C1 NICHHD, Lab Phys & Struct Biol, NIH, Bethesda, MD 20892 USA.
RP Rau, DC (reprint author), NICHHD, Lab Phys & Struct Biol, NIH, Bldg 9,Rm 1E-122, Bethesda, MD 20892 USA.
RI Leikin, Sergey/A-5518-2008
OI Leikin, Sergey/0000-0001-7095-0739
NR 47
TC 29
Z9 31
U1 1
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5647
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD MAR 8
PY 2001
VL 105
IS 9
BP 1877
EP 1886
DI 10.1021/jp002531f
PG 10
WC Chemistry, Physical
SC Chemistry
GA 407JF
UT WOS:000167267900031
ER

PT J
AU Yamada, M
   Miyakawa, T
   Duttaroy, A
   Yamanaka, A
   Moriguchi, T
   Makita, R
   Ogawa, M
   Chou, CJ
   Xia, B
   Crawley, JN
   Felder, CC
   Deng, CX
   Wess, J
AF Yamada, M
   Miyakawa, T
   Duttaroy, A
   Yamanaka, A
   Moriguchi, T
   Makita, R
   Ogawa, M
   Chou, CJ
   Xia, B
   Crawley, JN
   Felder, CC
   Deng, CX
   Wess, J
TI Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and
   lean
SO NATURE
LA English
DT Article
ID MELANIN-CONCENTRATING HORMONE; LATERAL HYPOTHALAMIC AREA; KNOCKOUT MICE;
   FEEDING-BEHAVIOR; FOOD-INTAKE; RAT-BRAIN; PROTEIN; GENE; LOCALIZATION;
   PROJECTIONS
AB Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions(1,2). Identifying the specific receptor subtype( s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult primarily because of a lack of subtype-selective ligands(3). Here we show that mice deficient in the M3 muscarinic receptor (M3R(-/-) mice) display a significant decrease in food intake, reduced body weight and peripheral fat deposits, and very low levels of serum leptin and insulin. Paradoxically, hypothalamic messenger RNA levels of melanin-concentrating hormone (MCH), which are normally upregulated in fasted animals leading to an increase in food intake(4,5), are significantly reduced in M3R(-/-) mice. Intra-cerebroventricular injection studies show that an agouti-related peptide analogue lacked orexigenic (appetite-stimulating) activity in M3R(-/-) mice. However, M3R(-/-) mice remained responsive to the orexigenic effects of MCH. Our data indicate that there may be a cholinergic pathway that involves M3-receptor-mediated facilitation of food intake at a site downstream of the hypothalamic leptin/melanocortin system and upstream of the MCH system.
C1 NIDDKD, Bioorgan Chem Lab, Bethesda, MD 20892 USA.
   NIDDKD, Diabet Branch, Bethesda, MD 20892 USA.
   NIDDKD, Biochem & Metab Lab, Bethesda, MD 20892 USA.
   RIKEN, Brain Sci Inst, Lab Cell Culture Dev, Wako, Saitama 3510198, Japan.
   NIMH, Sect Behav Pharmacol, Expt Therapeut Branch, Bethesda, MD 20892 USA.
   Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan.
   NIAAA, Lab Membrane Biochem & Biophys, Rockville, MD 20852 USA.
   Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA.
RP Wess, J (reprint author), NIDDKD, Bioorgan Chem Lab, Bethesda, MD 20892 USA.
RI Miyakawa, Tsuyoshi/A-7741-2008; deng, chuxia/N-6713-2016
OI Miyakawa, Tsuyoshi/0000-0003-0137-8200; 
NR 30
TC 266
Z9 278
U1 0
U2 5
PU MACMILLAN PUBLISHERS LTD
PI LONDON
PA PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD MAR 8
PY 2001
VL 410
IS 6825
BP 207
EP 212
DI 10.1038/35065604
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 408HJ
UT WOS:000167320500046
PM 11242080
ER

PT J
AU Sterling, TR
   Vlahov, D
   Astemborski, J
   Hoover, DR
   Margolick, JB
   Quinn, TC
AF Sterling, TR
   Vlahov, D
   Astemborski, J
   Hoover, DR
   Margolick, JB
   Quinn, TC
TI Initial plasma HIV-1 RNA levels and progression to AIDS in women and
   men.
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article; Proceedings Paper
CT 13th International AIDS Conference
CY JUL 09-SEP 14, 2000
CL DURBAN, SOUTH AFRICA
ID VIRAL LOAD; NATURAL-HISTORY; SEX-DIFFERENCES; ANTIRETROVIRAL THERAPY;
   SERUM LEVELS; VIRUS LOAD; DRUG-USERS; SEROCONVERSION; INFECTION; DISEASE
AB Background: It is unclear whether there are differences between men and women with human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the viral load). In men, the initial viral load after seroconversion predicts the likelihood of progression to the acquired immunodeficiency syndrome (AIDS), but the relation between the two has not been assessed in women. Currently, the guidelines for initiating antiretroviral therapy are applied uniformly to women and men.
   Methods: From 1988 through 1998, the viral load and the CD4+ lymphocyte count were measured approximately every six months in 156 male and 46 female injection-drug users who were followed prospectively after HIV-1 seroconversion.
   Results: The median initial viral load was 50,766 copies of HIV-1 RNA per milliliter in the men but only 15,103 copies per milliliter in the women (P<0.001). The median initial CD4+ count did not differ significantly according to sex (659 and 672 cells per cubic millimeter, respectively). HIV-1 infection progressed to AIDS in 29 men and 15 women, and the risk of progression did not differ significantly according to sex. For each increase of 1 log in the viral load (on a base 10 scale), the hazard ratio for progression to AIDS was 1.55 (95 percent confidence interval, 0.97 to 2.47) among the men and 1.43 (95 percent confidence interval, 0.76 to 2.69) among the women. The median initial viral load was 77,822 HIV-1 RNA copies per milliliter in the men in whom AIDS developed and 40,634 copies per milliliter in the men in whom it did not; the corresponding values in the women were 17,149 and 12,043 copies per milliliter. Given the recommendation that treatment should be initiated when the viral load reaches 20,000 copies per milliliter, 74 percent of the men but only 37 percent of the women in our study would have been eligible for therapy at the first visit after seroconversion (P<0.001).
   Conclusions: Although the initial level of HIV-1 RNA was lower in women than in men, the rates of progression to AIDS were similar. Treatment guidelines that are based on the viral load, rather than the CD4+ lymphocyte count, will lead to differences in eligibility for antiretroviral treatment according to sex. (N Engl J Med 2001;344:720-5.) Copyright (C) 2001 Massachusetts Medical Society.
C1 Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21287 USA.
   Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
   New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA.
   Rutgers State Univ, Dept Stat, Piscataway, NJ USA.
   NIAID, Bethesda, MD 20892 USA.
RP Sterling, TR (reprint author), Johns Hopkins Univ, Sch Med, Div Infect Dis, 1830 E Monument St,Rm 444, Baltimore, MD 21287 USA.
RI Quinn, Thomas/A-2494-2010
FU NIAID NIH HHS [K23 AI01654]; NIDA NIH HHS [R0-1 DA04334, R0-1 DA08009]
NR 33
TC 190
Z9 196
U1 0
U2 1
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 8
PY 2001
VL 344
IS 10
BP 720
EP 725
DI 10.1056/NEJM200103083441003
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 408AX
UT WOS:000167305300003
PM 11236775
ER

PT J
AU Fischbach, GD
   McKhann, GM
AF Fischbach, GD
   McKhann, GM
TI Cell therapy for Parkinson's disease.
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Editorial Material
C1 NINDS, Bethesda, MD 20892 USA.
RP Fischbach, GD (reprint author), NINDS, Bethesda, MD 20892 USA.
NR 9
TC 19
Z9 23
U1 0
U2 0
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 8
PY 2001
VL 344
IS 10
BP 763
EP 765
DI 10.1056/NEJM200103083441011
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 408AX
UT WOS:000167305300011
PM 11236783
ER

PT J
AU Groh, WJ
   Salive, ME
   Richardson, LD
AF Groh, WJ
   Salive, ME
   Richardson, LD
CA Public Access Defibrillation Trial
TI Automated external defibrillators.
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 Indiana Univ, Indianapolis, IN 46202 USA.
   NIH, Bethesda, MD 20892 USA.
   CUNY, Mt Sinai Med Ctr, New York, NY 10029 USA.
RP Groh, WJ (reprint author), Indiana Univ, Indianapolis, IN 46202 USA.
NR 2
TC 2
Z9 2
U1 0
U2 0
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 8
PY 2001
VL 344
IS 10
BP 771
EP 772
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 408AX
UT WOS:000167305300014
PM 11236785
ER

PT J
AU Park, SH
   Kim, YS
   Park, BK
   Hougaard, S
   Kim, SJ
AF Park, SH
   Kim, YS
   Park, BK
   Hougaard, S
   Kim, SJ
TI Sequence-specific enhancer binding protein is responsible for the
   differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric
   cancer cell lines: Implication for the loss of TCF-beta type II receptor
   expression
SO ONCOGENE
LA English
DT Article
DE TGF-beta type II receptor; ets transcription factor; promoter; enhancer;
   gastric cancer
ID GROWTH-FACTOR-BETA; ETS TRANSCRIPTION FACTOR; TGF-BETA; MICROSATELLITE
   INSTABILITY; GENOMIC ORGANIZATION; FAMILY; MEMBER; INACTIVATION;
   REPRESSION; RESISTANCE
AB Transcriptional repression of the TGF-beta type II receptor (RII) is one of the mechanisms leading to TGF-beta resistance. The newly identified epithelium-specific ets transcription factor ERT/ESX/ELF-3/ESE-1/jen binds to the TGF-beta RII promoter and induces promoter activity. The human gastric cancer cell lines, which show undetectable level of TGF-beta RII mRNA, do not express ERT mRNA, To study the molecular mechanisms of loss of ERT expression, we have cloned and characterized the human ERT promoter, DNA transfection experiments and electrophoretic mobility shift assays have revealed the existence of a distinct enhancer element (-186 to -177) which we named ESE ((E) under bar RT promoter Specific element). Deletion of the ESE markedly decreased expression of the target gene. ESE interacts with two distinct nuclear protein complexes, at least one of which appears to be inactivated in a cell line which does not express the ERT mRNA, compared to a cell line expressing the ERT mRNA, These results suggest the possibility that inactivation of the sequence-specific DNA binding protein to the region from -186 to -177 contributes to the loss of ERT expression, leading to the loss of TGF-beta type II receptor mRNA in human gastric cancer cell lines.
C1 NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA.
   Gyeongsang Natl Univ, Coll Med, Dept Pediat, Chinju 660702, South Korea.
RP Kim, SJ (reprint author), NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA.
NR 32
TC 15
Z9 16
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 8
PY 2001
VL 20
IS 10
BP 1235
EP 1245
DI 10.1038/sj.onc.1204227
PG 11
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
GA 412TH
UT WOS:000167570100011
PM 11313868
ER

PT J
AU Kim, SG
   Kim, SN
   Jong, HS
   Kim, NK
   Hong, SH
   Kim, SJ
   Bang, YJ
AF Kim, SG
   Kim, SN
   Jong, HS
   Kim, NK
   Hong, SH
   Kim, SJ
   Bang, YJ
TI Caspase-mediated Cdk2 activation is a critical step to execute
   transforming growth factor-beta 1-induced apoptosis in human gastric
   cancer cells
SO ONCOGENE
LA English
DT Article
DE TGF-beta 1; apoptosis; caspase-3; cyclin-dependent kinase-2; p21(cip1);
   p27(kip1)
ID DEPENDENT PROTEIN-KINASES; FACTOR-BETA; TGF-BETA; CYCLE ARREST;
   RETINOBLASTOMA PROTEIN; EPITHELIAL-CELLS; THYMOCYTE APOPTOSIS;
   HEPATOMA-CELLS; INHIBITION; DEATH
AB Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined, Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells mere initially arrested at the G1 phase and then driven into apoptosis, Of note, caspase-3 was activated in accordance with TGF-beta1-induced G1 arrest, Activated caspase-3 is targeted to cleave p21(cip1), p27(kip1), and Rb, which play important roles in TGF-beta -induced G1 arrest, into;inactive fragments. Subsequently, Cdk2 was aberrantly activated due to the cleavage of p21 and p27, We found that the inhibition of Cdk2 activity efficiently blocks TGF-beta1-induced apoptosis, whereas it did; not prevent caspase-3 activation or the subsequent cleavage of target proteins, In contrast, the suppression of caspase-3 activity inhibited the cleavage of target proteins, the activation of Cdk2, and the induction of apoptosis. Taken together, our results suggest that activation of caspase-3 by TGF-beta1 may initiate the conversion from G1 cell cycle arrest to apoptosis via the cleavage of p21, p27 and Rb, which in turn causes Cdk2 activation and, most significantly, Cdk2 activation as a downstream effector of caspase is a critical step for the execution TGF-beta1-induced apoptosis.
C1 Seoul Natl Univ, Coll Med, Dept Internal Med, Canc Res Inst, Seoul 110744, South Korea.
   Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea.
   Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea.
   Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea.
   NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA.
RP Bang, YJ (reprint author), Seoul Natl Univ, Coll Med, Dept Internal Med, Canc Res Inst, 28 Yongon Dong, Seoul 110744, South Korea.
RI Bang, Yung Jue/J-2759-2012
NR 45
TC 42
Z9 42
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 8
PY 2001
VL 20
IS 10
BP 1254
EP 1265
DI 10.1038/sj.onc.1204203
PG 12
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
GA 412TH
UT WOS:000167570100013
PM 11313870
ER

PT J
AU Flynn, BL
   Verdier-Pinard, P
   Hamel, E
AF Flynn, BL
   Verdier-Pinard, P
   Hamel, E
TI A novel palladium-mediated coupling approach to 2,3-disubstituted
   benzo[b]thiophenes and its application to the synthesis of tubulin
   binding agents
SO ORGANIC LETTERS
LA English
DT Article
ID ESTROGEN-RECEPTOR MODULATORS; CELL ACTIVATION INHIBITOR; HALOCYCLIZATION
   REACTIONS; UNSATURATED SULFIDES; COMBRETASTATIN; DERIVATIVES; POTENT;
   ANTIESTROGENS; THIOPHENES; CI-959
AB [GRAPHICS]
   Flexible, convergent access to 2,3-disubstituted benzo[b]thiophenes has been developed. The most concise approach involves sequential coupling of o-bromoiodobenzenes with benzylmercaptan and zinc acetylides to give benzyl o-ethynylphenyl sulfides which react with iodine to give 3-iodobenzo[b]thiophenes in a 5-endo-dig iodocyclization. These iodides can be further elaborated using palladium-mediated coupling and/or metalation techniques. This method has been applied to the synthesis of some novel tubulin binding agents.
C1 Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia.
   NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Screening Technol Branch, Frederick, MD 21702 USA.
RP Flynn, BL (reprint author), Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia.
OI Verdier-Pinard, Pascal/0000-0002-6149-6578
NR 39
TC 192
Z9 193
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1523-7060
J9 ORG LETT
JI Org. Lett.
PD MAR 8
PY 2001
VL 3
IS 5
BP 651
EP 654
DI 10.1021/ol0067179
PG 4
WC Chemistry, Organic
SC Chemistry
GA 408JH
UT WOS:000167322700003
PM 11259028
ER

PT J
AU Ahmad, A
   Greiner, RS
   Moriguchi, T
   Salem, N
AF Ahmad, A
   Greiner, RS
   Moriguchi, T
   Salem, N
TI Docosahexaenoic acid deficiency causes reduction in neuronal size in the
   hippocampus, piriform cortex and subfornical organ.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA, NIH, Rockville, MD 20852 USA.
   Wakunaga Pharmaceut Co Ltd, Hiroshima 7391105, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A190
EP A190
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101082
ER

PT J
AU Anderson, CC
   Cheever, AW
   Matzinger, P
AF Anderson, CC
   Cheever, AW
   Matzinger, P
TI Turning foreign into self: Tolerance induction to a healed graft without
   immunosuppression.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Biomed Res Inst, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A671
EP A671
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103853
ER

PT J
AU Apasov, SG
   Sitkovsky, MV
AF Apasov, SG
   Sitkovsky, MV
TI Study of adenosine signaling in T cell development and ADA SCID.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A710
EP A710
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104079
ER

PT J
AU Armant, MA
   Henry, NL
   Nutman, TB
AF Armant, MA
   Henry, NL
   Nutman, TB
TI Increased cellular responsiveness to IL-12 in a chronic helminth
   infection
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Washington Univ, Sch Med, St Louis, MO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A690
EP A690
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103965
ER

PT J
AU Bae, MA
   Rhee, H
   Song, BJ
AF Bae, MA
   Rhee, H
   Song, BJ
TI Cytotoxic mechanism of Troglitazone, a widely-used drug for type II
   non-insulin dependent diabetes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA, NIH, Rockville, MD 20852 USA.
   US FDA, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A507
EP A507
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102900
ER

PT J
AU Baek, SJ
   Kim, KS
   Nixon, JB
   Wilson, LC
   Eling, TE
AF Baek, SJ
   Kim, KS
   Nixon, JB
   Wilson, LC
   Eling, TE
TI Expression of NSAID activated gene, NAG-1, is associated with
   NSAID-induced apoptosis and anti-tumorigenesis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A563
EP A563
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103221
ER

PT J
AU Baer, DJ
   Judd, JT
   Muesing, R
   Campbell, WS
   Brown, ED
   Taylor, PR
AF Baer, DJ
   Judd, JT
   Muesing, R
   Campbell, WS
   Brown, ED
   Taylor, PR
TI Plasma lipid changes in response to moderate alcohol consumption by
   postmenopausal women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD USA.
   George Washington Univ, Washington, DC 20052 USA.
   NCI, Canc Prevent & Control Branch, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A638
EP A638
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103659
ER

PT J
AU Baker, TA
   Milstien, S
   Katusic, ZS
AF Baker, TA
   Milstien, S
   Katusic, ZS
TI Vitamin C increases the availability of tetrahydrobiopterin in human
   endothelial cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Mayo Clin, Rochester, MN 55905 USA.
   NIH, NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A451
EP A451
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102578
ER

PT J
AU Basu, NK
   Kole, L
   Kubota, S
   Owens, IS
AF Basu, NK
   Kole, L
   Kubota, S
   Owens, IS
TI Glucuronidation of mycophenolic acid by UGT1A isoforms and their
   downregulations.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A174
EP A174
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100987
ER

PT J
AU Bhathena, SJ
   Hansen, CT
   Velasquez, MT
AF Bhathena, SJ
   Hansen, CT
   Velasquez, MT
TI Relationship of leptin to insulin and glycemia in a rat model of obesity
   (ob) and non-insulin-dependent diabetes mellitus (NIDDM)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 USDA, Beltsville Agr Res Ctr, Phytonutrients Lab, Beltsville, MD 20705 USA.
   NIH, Anim Genet Resource, Bethesda, MD 20892 USA.
   George Washington Univ, Med Ctr, Dept Med, Washington, DC 20037 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A299
EP A299
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101706
ER

PT J
AU Borrego, F
   Zhang, MC
   Maasho, K
   Kim, DK
   Kabat, J
   Valas, RB
   Coligan, JE
AF Borrego, F
   Zhang, MC
   Maasho, K
   Kim, DK
   Kabat, J
   Valas, RB
   Coligan, JE
TI Characterization of the basal promoter of human CD94
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, Natl Inst Hlth, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A698
EP A698
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104011
ER

PT J
AU Bortner, CD
   Cidlowski, JA
AF Bortner, CD
   Cidlowski, JA
TI Glucocorticoid-induced plasma membrane depolarization in lymphoid cells:
   A Bcl-2 inhibitable process.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A508
EP A508
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102902
ER

PT J
AU Brodie, C
   Blass, M
   Blumberg, PM
   Kronfeld, I
AF Brodie, C
   Blass, M
   Blumberg, PM
   Kronfeld, I
TI Tyrosine phosphorylation of PKC delta is essential for the apoptosis
   induced by etoposide and gamma-irradiation.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Bar Ilan Univ, IL-52900 Ramat Gan, Israel.
   NCI, NIH, LCCTP, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A546
EP A546
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103126
ER

PT J
AU Brown, LM
   Hansen, CT
   Castonguay, TW
AF Brown, LM
   Hansen, CT
   Castonguay, TW
TI Chemiluminescent in situ hybridization of the melanocortin-4 receptor in
   lean and obese Agouti mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Maryland, College Pk, MD 20742 USA.
   NIH, Genet Resource Div, Bethesda, MD 20895 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A597
EP A597
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103421
ER

PT J
AU Chan, HW
   Kurago, ZB
   Carrington, M
   Wilson, MJ
   Trowsdale, J
   Lutz, CT
AF Chan, HW
   Kurago, ZB
   Carrington, M
   Wilson, MJ
   Trowsdale, J
   Lutz, CT
TI Expression of NK cell KIR genes is either mono-allelic or bi-allelic and
   is controlled by DNA methylation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Iowa, Dept Pathol, Iowa City, IA 52241 USA.
   NCI, Frederick, MD 21701 USA.
   Univ Cambridge, Cambridge, England.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A693
EP A693
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103980
ER

PT J
AU Chen, HL
   Ward, MH
   Graubard, BI
   Heineman, EF
   Markin, RM
   Potischman, NA
   Russell, RM
   Weisenburger, DD
   Tucker, KL
AF Chen, HL
   Ward, MH
   Graubard, BI
   Heineman, EF
   Markin, RM
   Potischman, NA
   Russell, RM
   Weisenburger, DD
   Tucker, KL
TI Dietary patterns and adenocarcinoma of the esophagus and distal stomach
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Tufts Univ, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   NCI, Bethesda, MD 20892 USA.
   Univ Nebraska, Med Ctr, Lincoln, NE USA.
RI Tucker, Katherine/A-4545-2010
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A616
EP A616
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103530
ER

PT J
AU Chen, LY
   Pan, CJ
   Chou, JY
AF Chen, LY
   Pan, CJ
   Chou, JY
TI Structural-function analysis of human glucose-6-phosphate transporter
   deficient in glycogen storage disease type 1b
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, HDB, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A532
EP A532
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103043
ER

PT J
AU Chen, X
   Mellon, RD
   Oppenheim, JJ
   Howard, OMZ
AF Chen, X
   Mellon, RD
   Oppenheim, JJ
   Howard, OMZ
TI Regulatory effects of deoxycholic acid (DCA), one component of anti
   inflammatory traditional Chinese drug-Niuhuang, on human leukocyte
   response to chemoattractants
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
RI Howard, O M Zack/B-6117-2012; Chen, Xin/I-6601-2015
OI Howard, O M Zack/0000-0002-0505-7052; Chen, Xin/0000-0002-2628-4027
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A358
EP A358
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102050
ER

PT J
AU Chen, ZM
   Gramglia, I
   O'Shaughnessy, M
   Panoskaltsis-Mortari, A
   Murphy, W
   Narula, K
   Moore, K
   Roncarolo, MG
   Blazar, BR
AF Chen, ZM
   Gramglia, I
   O'Shaughnessy, M
   Panoskaltsis-Mortari, A
   Murphy, W
   Narula, K
   Moore, K
   Roncarolo, MG
   Blazar, BR
TI IL-10 and TGF-beta treated primary MLR: A source of immune regulatory
   cells that inhibit alloresponses in vitro and suppress GVHD in vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Minnesota, Canc Res Ctr, Minneapolis, MN 55455 USA.
   NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
   Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA.
   Hosp San Raffaele, I-20132 Milan, Italy.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A667
EP A667
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103828
ER

PT J
AU Cho, HS
   Kehrl, JH
AF Cho, HS
   Kehrl, JH
TI RGS14, a regulator of heterotrimeric G-protein signaling localizes to
   centrosome and interacts with a centrosome protein, ninien.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A577
EP A577
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103302
ER

PT J
AU Choi, CY
   Kim, YH
   Gajewski, K
   Schulz, RA
   Kim, Y
AF Choi, CY
   Kim, YH
   Gajewski, K
   Schulz, RA
   Kim, Y
TI Role for the nuclear protein kinase HIPK2 in corepressor activity of
   Groucho during development
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Mol Cardiol Lab, Bethesda, MD 20892 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A209
EP A209
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101188
ER

PT J
AU Connor, JH
   Li, S
   Hallenbeck, JM
   Shenolikar, S
AF Connor, JH
   Li, S
   Hallenbeck, JM
   Shenolikar, S
TI The growth arrest and DNA-damage inducible gene product, GADD-34,
   recruits protein phosphatase-1 and its regulator, Inhibitor-1, to
   control protein synthesis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Duke Univ, Med Ctr, LSRC, Durham, NC 27710 USA.
   NINDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A1
EP A1
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100004
ER

PT J
AU Cowdery, JS
   Morse, H
   Schroeder, A
   Bradford, M
AF Cowdery, JS
   Morse, H
   Schroeder, A
   Bradford, M
TI CpG-DNA-induced murine IL-12 p40 secretion is independent of STAT1 but
   is ICSBP-dependent
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Dept Vet Affairs, Iowa City, IA 52242 USA.
   Univ Iowa, Iowa City, IA 52242 USA.
   NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A347
EP A347
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101984
ER

PT J
AU Cristillo, AD
   Bierer, BE
AF Cristillo, AD
   Bierer, BE
TI Upregulation of HIV-coreceptor CXCR4 expression in Human T lymphocytes
   is mediated by putative CRE element in CXCR4 promoter
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NHLBI, Lab Lymphocyte Biol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A362
EP A362
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102072
ER

PT J
AU Cui, YH
   Le, YY
   Gong, WH
   Dunlop, NM
   Wang, JM
AF Cui, YH
   Le, YY
   Gong, WH
   Dunlop, NM
   Wang, JM
TI Induction of expression of functional chemotactic formyl peptide
   receptor in murine microglial cells by bacterial lipopolysaccharide
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
   SAIC, Intramural Res Support Program, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A336
EP A336
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101922
ER

PT J
AU Dai, D
AF Dai, D
TI Allelic frequencies of human CYP2C8 and genetic linkage among different
   ethnic populations
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, LPC, Res Triangle Pk, NC 27709 USA.
NR 0
TC 4
Z9 4
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A575
EP A575
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103288
ER

PT J
AU Dai, D
AF Dai, D
TI Allelic variations of human CYP3A4.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, LPC, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A182
EP A182
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101033
ER

PT J
AU Dawson, HD
   Sullivan, JM
   Pyle, RS
   Taub, DD
AF Dawson, HD
   Sullivan, JM
   Pyle, RS
   Taub, DD
TI Homocysteine sensitizes T cells to apoptotic stimuli
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, Baltimore, MD 21224 USA.
   NIH, Baltimore, MD 21224 USA.
RI Dawson, Harry/H-8242-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A314
EP A314
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101796
ER

PT J
AU Dobbins, DE
   Joe, B
   Hashiramoto, A
   Remmers, EF
   Wilder, RL
AF Dobbins, DE
   Joe, B
   Hashiramoto, A
   Remmers, EF
   Wilder, RL
TI An improved radiation hybrid map of the proximal region of rat
   chromosome 10 which contains the mutation responsible for osteopetrosis
   in the op rat.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
   NIAMS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A486
EP A486
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102778
ER

PT J
AU Dunn, BM
   Beyer, BB
   Li, M
   Gustchina, A
   Dauter, Z
   Oda, K
   Wlodawer, A
AF Dunn, BM
   Beyer, BB
   Li, M
   Gustchina, A
   Dauter, Z
   Oda, K
   Wlodawer, A
TI Structure and substrate specificity of PSCP, a novel serine-carboxyl
   peptidase from Pseudomonas
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Florida, Gainesville, FL 32610 USA.
   NCI, Program Struct Biol, Frederick, MD 21702 USA.
   Brookhaven Natl Lab, Upton, NY 11973 USA.
   Kyoto Inst Technol, Sakyo Ku, Kyoto 6068585, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A23
EP A23
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100125
ER

PT J
AU Ecelbarger, CA
   Bickel, CA
   Knepper, MA
   Verbalis, JG
AF Ecelbarger, CA
   Bickel, CA
   Knepper, MA
   Verbalis, JG
TI Renal sodium and water transporter abundance in the diabetic obese
   Zucker rat
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Georgetown Univ, Washington, DC 20007 USA.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A467
EP A467
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102669
ER

PT J
AU Evans, DH
   Stidham, JD
   Karnaky, K
   Miller, DS
AF Evans, DH
   Stidham, JD
   Karnaky, K
   Miller, DS
TI Endothelin and nitric oxide regulation of NaCl extrusion across the
   teleost fish gill.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Mt Desert Isl Biol Lab, Salsbury Cove, ME 04672 USA.
   Presbyterian Coll, Clinton, SC 29325 USA.
   Med Univ S Carolina, Charleston, SC 29425 USA.
   NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A413
EP A413
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102360
ER

PT J
AU Ferguson, SS
   Negishi, M
   Goldstein, JA
AF Ferguson, SS
   Negishi, M
   Goldstein, JA
TI Mechanistic investigation of phenobarbital induction of the human CYP2Cs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A523
EP A523
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102995
ER

PT J
AU Fuller, CL
   Bunnell, SC
   Braciale, VL
   Samelson, LE
AF Fuller, CL
   Bunnell, SC
   Braciale, VL
   Samelson, LE
TI CTL activation-induced cytoskeletal remodeling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NCI, Lab Cell & Mol Biol, Bethesda, MD 20892 USA.
   Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A705
EP A705
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104051
ER

PT J
AU Gardner, KL
   Haggerty, CM
AF Gardner, KL
   Haggerty, CM
TI The selective subnuclear partitioning and functional biochemistry of
   p300
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Ctr Adv Technol, Gaithersburg, MD 20877 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A2
EP A2
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100009
ER

PT J
AU Greenwell-Wild, T
   Hale-Donze, H
   Orenstein, JM
   Wahl, SM
AF Greenwell-Wild, T
   Hale-Donze, H
   Orenstein, JM
   Wahl, SM
TI Mycobacterium avium infection and regulation of human macrophage gene
   expression
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIDCR, OIIB, Bethesda, MD 20892 USA.
   George Washington Univ, Washington, DC 20037 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A650
EP A650
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103727
ER

PT J
AU Han, J
   Le, P
   Sobel, ME
AF Han, J
   Le, P
   Sobel, ME
TI The 5'untranslated region of the human RPSA gene contains a
   stability-conferring motif
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A249
EP A249
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101423
ER

PT J
AU Hartman, TJ
   Graham, LB
   Parker, CE
   Tomer, KB
   Baer, DJ
   Brown, ED
   Dorgan, JF
   Campbell, WS
   Judd, JT
   Taylor, PR
AF Hartman, TJ
   Graham, LB
   Parker, CE
   Tomer, KB
   Baer, DJ
   Brown, ED
   Dorgan, JF
   Campbell, WS
   Judd, JT
   Taylor, PR
TI Moderate alcohol consumption and isoprostane levels in postmenopausal
   women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Penn State Univ, University Pk, PA 16802 USA.
   NIEHS, Res Triangle Pk, NC 27709 USA.
   USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
   Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
   NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A401
EP A401
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102294
ER

PT J
AU Hartman, TJ
   Baer, DJ
   Stone, W
   Ponder, T
   Brown, ED
   Albanes, D
   Dorgan, JF
   Campbell, WS
   Judd, JT
   Taylor, PR
AF Hartman, TJ
   Baer, DJ
   Stone, W
   Ponder, T
   Brown, ED
   Albanes, D
   Dorgan, JF
   Campbell, WS
   Judd, JT
   Taylor, PR
TI Tthe effects of moderate alcohol consumption on vitamin E levels in
   postmenopausal women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Penn State Univ, University Pk, PA 16802 USA.
   USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD USA.
   E Tennessee State Univ, Johnson City, TN 37614 USA.
   NCI, Bethesda, MD 20892 USA.
   Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
RI Albanes, Demetrius/B-9749-2015; Stone, William/B-6499-2008
OI Stone, William/0000-0002-6829-0417
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A261
EP A261
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101492
ER

PT J
AU Hodge, DL
   Martinez, A
   Julias, JG
   Taylor, LS
   Young, HA
AF Hodge, DL
   Martinez, A
   Julias, JG
   Taylor, LS
   Young, HA
TI Posttranscriptional control of interferon-gamma gene expression by
   IL-12: A novel form of nuclear regulation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, DBS, LEI, Frederick, MD 21702 USA.
RI Young, Howard/A-6350-2008
OI Young, Howard/0000-0002-3118-5111
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A347
EP A347
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101987
ER

PT J
AU Hoffmann, SC
   Stanley, EM
   Cox, ED
   DiMercurio, BS
   Koziol, DE
   Harlan, DM
   Kirk, AD
   Blair, PJ
AF Hoffmann, SC
   Stanley, EM
   Cox, ED
   DiMercurio, BS
   Koziol, DE
   Harlan, DM
   Kirk, AD
   Blair, PJ
TI Correlation of cytokine gene polymorphic inheritance and in vitro
   cytokine production in anti-CD3/CD28 stimulated peripheral blood
   lymphocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, Bethesda, MD 20889 USA.
   Walter Reed Army Med Ctr, Bethesda, MD 20889 USA.
RI Kirk, Allan/B-6905-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A666
EP A666
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103825
ER

PT J
AU Hong, HHL
   Hayashi, SM
   Toyoda, K
   Ton, TT
   Devereux, TR
   Maronpot, RR
   Sills, RC
AF Hong, HHL
   Hayashi, SM
   Toyoda, K
   Ton, TT
   Devereux, TR
   Maronpot, RR
   Sills, RC
TI High frequency of ras mutations in forestomach and lung tumors induced
   by 1-amino-2,4-dibromoanthraquinone in mice.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, LEP, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A249
EP A249
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101426
ER

PT J
AU Huang, STJ
   Cidlowski, JA
AF Huang, STJ
   Cidlowski, JA
TI Bcl-2 phosphorylation status modulates glucocorticoid action in
   T-lymphocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
RI Huang, Se-Te/F-6881-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A506
EP A506
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102892
ER

PT J
AU Hurley, JH
   Tsujishita, Y
   Misra, S
   Ho, J
   Burden, L
   Beach, B
AF Hurley, JH
   Tsujishita, Y
   Misra, S
   Ho, J
   Burden, L
   Beach, B
TI Protein modules: Keys to allosteric regulation and subcellular targeting
   in signal transduction.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A167
EP A167
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100947
ER

PT J
AU Hursting, SD
   Perkins, SN
   Donehower, LA
   Thompson, HJ
   Davis, BJ
AF Hursting, SD
   Perkins, SN
   Donehower, LA
   Thompson, HJ
   Davis, BJ
TI Nutritional modulation of spontaneous mammary tumorigenesis in
   p53-deficient MMTV-Wnt-1 transgenic mice.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   Baylor Coll Med, Houston, TX 77030 USA.
   AMC Canc Res Ctr, Lakewood, CO 80214 USA.
   NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A401
EP A401
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102293
ER

PT J
AU Javitt, NB
   Lee, YC
   Strott, CA
AF Javitt, NB
   Lee, YC
   Strott, CA
TI Sulfotransferase enzymes hHST 2A1 and 2B1a/b: Unmasking their substrate
   specificity as DHEA and cholesterol sulfotransferases respectively.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A30
EP A30
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100164
ER

PT J
AU Johnson, AC
   Rikiyama, T
   Nishi, H
   Jeang, KT
AF Johnson, AC
   Rikiyama, T
   Nishi, H
   Jeang, KT
TI GCF2 represses epidermal growth factor receptor expression and inhibits
   TAT activation of the HIV-LTR promoter
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   NCI, Bethesda, MD 20892 USA.
   NIAID, Bethesda, MD 20892 USA.
RI Jeang, Kuan-Teh/A-2424-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A531
EP A531
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103037
ER

PT J
AU Johnson, EN
   Druey, KM
AF Johnson, EN
   Druey, KM
TI Characterization of the regulator of G-protein signaling 13.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A578
EP A578
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103306
ER

PT J
AU Kabat, J
   Brooks, A
   Borrego, F
   Posh, PP
   Kim, DK
   Valas, R
   Coligan, JE
AF Kabat, J
   Brooks, A
   Borrego, F
   Posh, PP
   Kim, DK
   Valas, R
   Coligan, JE
TI Analysis of the role that each NKG2A ITIM motif plays in CD94/NKG2A
   signal initiation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Bethesda, MD USA.
   Univ Melbourne, Parkville, Vic 3052, Australia.
   Georgetown Univ, Washington, DC 20057 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A709
EP A709
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104075
ER

PT J
AU Kaminski, R
   Gasior, M
   Witkin, JM
AF Kaminski, R
   Gasior, M
   Witkin, JM
TI Distinct phases of cocaine-kindled seizures are differentially
   controlled by antiepileptics
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Natl Inst Drug Abuse, Baltimore, MD 21224 USA.
   IRP, Baltimore, MD 21224 USA.
NR 0
TC 2
Z9 2
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A223
EP A223
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101272
ER

PT J
AU Karnaky, KJ
   Petzel, D
   Sedmerova, M
   Miller, DS
AF Karnaky, KJ
   Petzel, D
   Sedmerova, M
   Miller, DS
TI MRP2-like transport in Malpighian tubules of the domestic brown cricket,
   Acheta domesticus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Creighton Univ, Sch Med, Omaha, NE 68178 USA.
   Med Univ S Carolina, Charleston, SC 29425 USA.
   NIH, NIEHS, Chem Pharmacol Lab, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A445
EP A445
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102545
ER

PT J
AU Kasai, T
   Iha, H
   Iwanaga, Y
   Jeang, KT
AF Kasai, T
   Iha, H
   Iwanaga, Y
   Jeang, KT
TI Impaired mitotic checkpoint in HTLV-I transformed cell lines:
   implications for chemotherapeutics of adult T-cell leukemia.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
RI Jeang, Kuan-Teh/A-2424-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A514
EP A514
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102943
ER

PT J
AU Kelly, JA
   Spolski, R
   Imada, K
   Bollenbacher, J
   Xue, HH
   Lee, S
   Leonard, W
AF Kelly, JA
   Spolski, R
   Imada, K
   Bollenbacher, J
   Xue, HH
   Lee, S
   Leonard, W
TI Reconstitution of Stat5a knockout mice by a transgene expressing Stat5b.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Lab Mol Immunol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A711
EP A711
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104089
ER

PT J
AU Kreppel, LK
   Kimmel, AR
AF Kreppel, LK
   Kimmel, AR
TI The role of presenilins in signal transduction in Dictyostelium.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A204
EP A204
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101160
ER

PT J
AU Kuhns, DB
   Nelson, EL
   Alvord, WG
   Gallin, JI
AF Kuhns, DB
   Nelson, EL
   Alvord, WG
   Gallin, JI
TI Fibrinogen regulation of interleukin-8 (IL-8) synthesis in human
   neutrophils
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 SAIC Frederick, Frederick, MD USA.
   NCI, Frederick, MD 21702 USA.
   NCI, Data Management Serv, Frederick, MD 21702 USA.
   NIH, NIAID, Host Def Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A335
EP A335
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101917
ER

PT J
AU Laufer, EM
   Hartman, TJ
   Baer, DJ
   Gunter, E
   Dorgan, JF
   Campbell, WS
   Brown, ED
   Albanes, D
   Judd, JT
   Taylor, PR
AF Laufer, EM
   Hartman, TJ
   Baer, DJ
   Gunter, E
   Dorgan, JF
   Campbell, WS
   Brown, ED
   Albanes, D
   Judd, JT
   Taylor, PR
TI The effects of moderate alcohol consumption on serum folate, vitamin
   B-12, and homocysteine levels in postmenopausal women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Penn State Univ, University Pk, PA 16802 USA.
   USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD USA.
   Ctr Dis Control, Atlanta, GA 30333 USA.
   Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
   NCI, Bethesda, MD 20892 USA.
RI Albanes, Demetrius/B-9749-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A262
EP A262
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101498
ER

PT J
AU Le, YY
   Gong, WH
   Tiffany, HL
   Tumanov, A
   Nedospasov, S
   Shen, WP
AF Le, YY
   Gong, WH
   Tiffany, HL
   Tumanov, A
   Nedospasov, S
   Shen, WP
TI Identification of a functional receptor for amyloid beta, the
   key-contributor to the Alzheimer's disease
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
   SAIC, Intramural Res Support Program, Frederick, MD 21702 USA.
   NIAID, Host Def Lab, Bethesda, MD 20892 USA.
RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015;
   Nedospasov, Sergei/Q-7319-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A684
EP A684
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103928
ER

PT J
AU Leak, LV
   Petricoin, EF
   Liotta, LA
   Jones, M
AF Leak, LV
   Petricoin, EF
   Liotta, LA
   Jones, M
TI Proteomic analysis of lymph and plasma during cardiopulmonary bypass
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Howard Univ, Washington, DC 20059 USA.
   US FDA, Div Therapeut Prod, Bethesda, MD 20892 USA.
   NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
   NHLBI, Lab Anim Med & Surg, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A38
EP A38
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100209
ER

PT J
AU Lee, HI
   Yim, MB
   Chock, PB
   Stadtman, ER
AF Lee, HI
   Yim, MB
   Chock, PB
   Stadtman, ER
TI The structure and enzyme-like activity of the free radical site
   generated in the glyoxal-mediated cross-linked proteins
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A180
EP A180
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101021
ER

PT J
AU Leiderman, YI
   Stowers, AW
   Long, CA
AF Leiderman, YI
   Stowers, AW
   Long, CA
TI CD40L is required for merozoite surface protein1-19 (MSP1-19)
   vaccine-mediated protection from lethal malaria challenge in a murine
   model
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Bethesda, MD 20892 USA.
   NIAID, Malaria Vaccine Dev Unit, NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A688
EP A688
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103951
ER

PT J
AU Lewis, KC
   Hochadel, JF
   Zech, LA
AF Lewis, KC
   Hochadel, JF
   Zech, LA
TI Long-term administration of the synthetic retinoid
   N-[4-hydroxyphenyl]retinamide (4-HPR) is associated with gradual
   displacement of native retinoid in the eye.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Basic Res Lab, Drug Nutr Interact Grp, NIH, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A256
EP A256
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101460
ER

PT J
AU Li, J
   Ikeyama, S
   Liu, Y
AF Li, J
   Ikeyama, S
   Liu, Y
TI Histone H3 modification in response to epidermal growth factor and
   arsenite declines with age in primary rat hepatocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, NIH, Cellular & Mol Biol Lab, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A10
EP A10
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100058
ER

PT J
AU Li, JF
   Olariu, A
   Wu, JF
   Huang, FL
   Huang, KP
AF Li, JF
   Olariu, A
   Wu, JF
   Huang, FL
   Huang, KP
TI Neurogranin knockout mice as a model to investigate the neuronal Ca2+-
   and calmodulin-dependent signaling pathways
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A177
EP A177
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101004
ER

PT J
AU Liang, W
   Hoang, Q
   Curran, PK
   Fishman, PH
AF Liang, W
   Hoang, Q
   Curran, PK
   Fishman, PH
TI Persistent agonist-mediated regulation of human beta(1)- and
   beta(2)-adrenergic receptors is subtype-specific
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NINDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A217
EP A217
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101236
ER

PT J
AU Lippert, E
   Druey, KM
AF Lippert, E
   Druey, KM
TI Regulation of chemokine-induced chemotaxis in T-lymphocytes by RGS16.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID, NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A360
EP A360
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102063
ER

PT J
AU Liu, Y
   Graham, C
   Li, AQ
   Shaw, S
AF Liu, Y
   Graham, C
   Li, AQ
   Shaw, S
TI Regulatory phosphorylation of the kinase domain of PKC-theta.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A6
EP A6
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100030
ER

PT J
AU Lopaczynski, W
   Miltyk, W
   Mahoney, C
   Albright, C
   Crowell, J
   Zeisel, SH
AF Lopaczynski, W
   Miltyk, W
   Mahoney, C
   Albright, C
   Crowell, J
   Zeisel, SH
TI Tyrosine phosphorylation, DNA damage and apoptosis in lymphocytes
   isolated from postmenopausal women and prostate cancer patients treated
   with a single dose of isoflavone mixture containing genistein.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC 27599 USA.
   NCI, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A600
EP A600
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103439
ER

PT J
AU Martin, KR
   Honeycutt, HP
   Kari, FW
   Barrett, C
   French, JE
AF Martin, KR
   Honeycutt, HP
   Kari, FW
   Barrett, C
   French, JE
TI Effect of supplemental N-acetyl-L-cysteine (NAC) on benzo(a)pyrene
   (BP)-induced tumor spectrum in male and female p53 haploinsufficient
   Tg.AC (v-Ha-ras) transgenic mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A619
EP A619
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103548
ER

PT J
AU McCartney-Francis, N
   Jin, WW
   Wahl, S
AF McCartney-Francis, N
   Jin, WW
   Wahl, S
TI Enhanced expression of toll-like receptor TLR4 and endotoxin
   hypersensitivity in mice lacking a functional TGF-beta signaling pathway
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A336
EP A336
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101924
ER

PT J
AU McVicar, DW
   Taylor, LS
   Winkler-Pickett, R
   Makrigiannis, AP
   Anderson, SK
   Bennett, M
   Ortaldo, JR
AF McVicar, DW
   Taylor, LS
   Winkler-Pickett, R
   Makrigiannis, AP
   Anderson, SK
   Bennett, M
   Ortaldo, JR
TI Aberrant Dap12 signaling in 120 mice: Implications for the analysis of
   gene targeted mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21702 USA.
   SAIC, Intramural Res Support Program, Frederick, MD 21702 USA.
   Univ Texas, SW Med Ctr, Dallas, TX 75235 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A707
EP A707
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104061
ER

PT J
AU Megjugorac, NJ
   Young, H
   Olshalsky, S
   Fitzgerald-Bocarsly, P
AF Megjugorac, NJ
   Young, H
   Olshalsky, S
   Fitzgerald-Bocarsly, P
TI Type 1 dendritic cells are potent inducers of TNF-alpha and chemokines
   MIP1-alpha, MIP1-beta, RANTES, and IP-10 in response to herpes simplex
   virus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA.
   Univ Med & Dent New Jersey, Grad Sch Biomed Sci, Newark, NJ 07103 USA.
   NCI, Frederick Canc Res & Dev Ctr, Expt Immunol Lab, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A308
EP A308
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101757
ER

PT J
AU Memon, SA
   Gress, RE
   Hakin, FT
AF Memon, SA
   Gress, RE
   Hakin, FT
TI CD4+T cell reconstitution correlates with thymic production in adults
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
RI Memon, Sarfraz/E-1198-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A666
EP A666
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103821
ER

PT J
AU Millman, JS
   Qi, HY
   Bernstein, H
   Andrews, DW
AF Millman, JS
   Qi, HY
   Bernstein, H
   Andrews, DW
TI FtsY binds to the Escherichia coli inner membrane via interactions with
   phosphatidylethanolamine and membrane proteins
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 McMaster Univ, Hamilton, ON L8N 3Z5, Canada.
   NIDDKD, Biochem & Genet Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A13
EP A13
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100069
ER

PT J
AU Miltyk, W
   Lopaczynski, W
   Mahoney, C
   Cooper, T
   Pagliei, J
   Smith, A
   Shah, T
   Craciunescu, CN
   Crowell, J
   Zeisel, SH
AF Miltyk, W
   Lopaczynski, W
   Mahoney, C
   Cooper, T
   Pagliei, J
   Smith, A
   Shah, T
   Craciunescu, CN
   Crowell, J
   Zeisel, SH
TI Genotoxic parameters in lymphocytes isolated from prostate cancer
   patients treated with multiple doses of isoflavone mixture.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC 27599 USA.
   NCI, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A616
EP A616
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103529
ER

PT J
AU Natarajan, K
   Eilat, D
   Margulies, DH
AF Natarajan, K
   Eilat, D
   Margulies, DH
TI Peptide specificity of the interaction between the natural killer cell
   inhibitory receptor Ly49C and H-2Kb ligand.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Hadassah Univ Hosp, Div Med, IL-91120 Jerusalem, Israel.
RI Margulies, David/H-7089-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A691
EP A691
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103967
ER

PT J
AU Necela, BM
   Cidlowski, JA
AF Necela, BM
   Cidlowski, JA
TI Generation of GFP-reporter genes to study glucocorticoid
   receptor-mediated gene activation in living cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIA, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A526
EP A526
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103009
ER

PT J
AU Nielsen, J
   Beutler, KT
   Knepper, MA
AF Nielsen, J
   Beutler, KT
   Knepper, MA
TI Spironolactone-mediated downregulation of the epithelial sodium channel
   (ENaC) in rat kidney.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A432
EP A432
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102469
ER

PT J
AU O'Brien, SJ
AF O'Brien, SJ
TI The promise of comparative genomics for the mammal radiation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A64
EP A64
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100361
ER

PT J
AU Oh, YK
   Na, KY
   Joo, KW
   Han, JS
   Lee, JS
   Earm, JH
   Kim, GH
   Knepper, MA
AF Oh, YK
   Na, KY
   Joo, KW
   Han, JS
   Lee, JS
   Earm, JH
   Kim, GH
   Knepper, MA
TI Chronic furosemide infusion increases expression of collecting duct
   epithelial sodium channel and H+-ATPase protein in rat kidney
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Seoul Natl Univ, Seoul, South Korea.
   Gachon Univ, Inchon, South Korea.
   Chungbuk Natl Univ, Cheongju, South Korea.
   Hallym Univ, Seoul, South Korea.
   NIH, NHLBI, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A142
EP A142
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100804
ER

PT J
AU Okagaki, R
   Oka, T
AF Okagaki, R
   Oka, T
TI Elucidation of regulatory factors involved in functional differentiation
   and involution of the mammary gland using an ovariohysterectomized
   pregnant mouse model
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A69
EP A69
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100389
ER

PT J
AU Okayama, Y
   Hagaman, DD
   Metcalfe, DD
AF Okayama, Y
   Hagaman, DD
   Metcalfe, DD
TI Profiles of mediators released or generated by IFN-gamma treated human
   mast cells following aggregation of Fc gamma RI.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A335
EP A335
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101916
ER

PT J
AU Onda, M
   Nagata, S
   Tsutsumi, Y
   Vincent, JJ
   Wang, QC
   Kreitman, RJ
   Lee, BK
   Pastan, I
AF Onda, M
   Nagata, S
   Tsutsumi, Y
   Vincent, JJ
   Wang, QC
   Kreitman, RJ
   Lee, BK
   Pastan, I
TI Lowering the isoelectric point of the Fv portion of recombinant
   immunotoxins leads to decreased non-specific animal toxicity without
   affecting antitumor activity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A534
EP A534
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103054
ER

PT J
AU Ortaldo, JR
   Bere, W
   Hodge, D
   Young, HA
AF Ortaldo, JR
   Bere, W
   Hodge, D
   Young, HA
TI Activating Ly-49 NK receptors: Central role in cytokine and chemokine
   production
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A362
EP A362
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102071
ER

PT J
AU Paliege, A
   Pohl, H
   Huang, G
   Briggs, JP
   Schnermann, J
AF Paliege, A
   Pohl, H
   Huang, G
   Briggs, JP
   Schnermann, J
TI Glomerular hypertrophy and increased NOS1 expression precede the
   development of glomerulosclerosis in COX-2 deficient mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A149
EP A149
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100849
ER

PT J
AU Perretti, M
   Wheller, SK
   Getting, SJ
   Gao, JL
AF Perretti, M
   Wheller, SK
   Getting, SJ
   Gao, JL
TI Interaction with the formylated receptor (FPR) is at the basis of
   annexin 1 anti-inflammatory effects
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 William Harvey Res Inst, London EC1M 6BQ, England.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A681
EP A681
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103911
ER

PT J
AU Piccirillo, CA
   Shevach, EM
AF Piccirillo, CA
   Shevach, EM
TI CD4+CD25+regulatory cells suppress CD8+T cells in the absence of APC by
   inhibiting CD25 expression.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIAID, LI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A353
EP A353
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102022
ER

PT J
AU Potischman, N
   Swanson, CA
   Coates, RJ
   Brinton, LA
AF Potischman, N
   Swanson, CA
   Coates, RJ
   Brinton, LA
TI The association of macronutrients, food groups and eating patterns with
   risk of breast cancer in young women.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RI Brinton, Louise/G-7486-2015
OI Brinton, Louise/0000-0003-3853-8562
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A62
EP A62
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100349
ER

PT J
AU Practorius, HA
   Spring, KR
AF Practorius, HA
   Spring, KR
TI The primary cilium of MDCK cells is a flow sensor
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A141
EP A141
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100801
ER

PT J
AU Praetorius, J
   Spring, KR
AF Praetorius, J
   Spring, KR
TI A large O-linked glycoprotein is confined to distinct sites on apical
   surface of MDCK cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A141
EP A141
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100803
ER

PT J
AU Prigozy, TI
   Naidenko, O
   Elewaut, D
   Brossay, L
   Qasba, P
   Khurana, A
   Natori, T
   Koezuka, Y
   Kulkarni, A
   Kronenberg, M
AF Prigozy, TI
   Naidenko, O
   Elewaut, D
   Brossay, L
   Qasba, P
   Khurana, A
   Natori, T
   Koezuka, Y
   Kulkarni, A
   Kronenberg, M
TI Antigen processing of glycolipids for presentation by CD1 molecules
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA.
   NIH, NINDS, Bethesda, MD 20892 USA.
   Kirin Brewery Co Ltd, Takasaki, Gumma 37012, Japan.
   NIH, NIDCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A677
EP A677
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103886
ER

PT J
AU Qasba, PK
AF Qasba, PK
TI Crystal structure of lactose synthase: Inactive to active state through
   a large conformational transititon
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A30
EP A30
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100166
ER

PT J
AU Quinones, MP
   Ahuja, SK
   Rao, A
   Melby, P
   Murphy, PM
   Gao, JL
   Ahuja, SS
AF Quinones, MP
   Ahuja, SK
   Rao, A
   Melby, P
   Murphy, PM
   Gao, JL
   Ahuja, SS
TI Obligate role of CCR1 expression in T cells for Th1 differentiation in
   vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA.
   NIH, NIAID, LHD, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A359
EP A359
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102053
ER

PT J
AU Rathore, D
   McCutchan, TF
AF Rathore, D
   McCutchan, TF
TI Structure function analysis of Plasmodium falciparum circumsporozoite
   protein: Role of cysteines in the binding activity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A531
EP A531
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103038
ER

PT J
AU Reddy, DS
   Castaneda, DC
   O'Malley, BW
   Rogawski, MA
AF Reddy, DS
   Castaneda, DC
   O'Malley, BW
   Rogawski, MA
TI Seizure resistance of progesterone receptor knockout mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Natl Inst Neurol Disorders & Stroke, Bethesda, MD 20892 USA.
   Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA.
RI Rogawski, Michael/B-6353-2009
OI Rogawski, Michael/0000-0002-3296-8193
NR 0
TC 8
Z9 8
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A223
EP A223
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101274
ER

PT J
AU Reyes-Cruz, G
   Spiegel, AM
AF Reyes-Cruz, G
   Spiegel, AM
TI Human calcium sensing receptor: Study of regions in the extracellular
   domain involved in the receptor activation.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A178
EP A178
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101011
ER

PT J
AU Roth, SM
   Schrager, MA
   Riechman, SE
   Ferrell, RE
   Metter, EJ
   Fleg, JL
   Hurley, BF
AF Roth, SM
   Schrager, MA
   Riechman, SE
   Ferrell, RE
   Metter, EJ
   Fleg, JL
   Hurley, BF
TI Ciliary neurotrophic factor (CNTF) genotype and body composition in men
   and women across the adult age span
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Pittsburgh, Pittsburgh, PA 15261 USA.
   Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   NIA, Gerontol Res Ctr, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A485
EP A485
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102771
ER

PT J
AU Royaux, IE
   Karniski, LP
   Everett, LA
   Knepper, MA
   Green, ED
   Wall, SM
AF Royaux, IE
   Karniski, LP
   Everett, LA
   Knepper, MA
   Green, ED
   Wall, SM
TI Pendrin, encoded by the Pendred syndrome gene, resides in the apical
   region of renal intercalated cells and mediates bicarbonate secretion
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NHGRI, Bethesda, MD 20892 USA.
   Univ Iowa, Iowa City, IA 52242 USA.
   Vet Affairs Med Ctr, Dept Internal Med, Iowa City, IA 52242 USA.
   NIH, NHLBI, Bethesda, MD USA.
   Univ Texas, Sch Med, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A502
EP A502
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102872
ER

PT J
AU Ruan, KH
   So, SP
   Wu, JX
   Li, D
   Huang, A
   Kung, J
AF Ruan, KH
   So, SP
   Wu, JX
   Li, D
   Huang, A
   Kung, J
TI Solution structure of the second extracellular loop of human thromboxane
   A(2) receptor
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Texas, Hlth Sci Ctr, Houston, TX 77030 USA.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A202
EP A202
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101148
ER

PT J
AU Samuel, W
   Nagineni, CN
   Kuty, RK
   Prouty, SM
   Hooks, JJ
   Wiggert, B
AF Samuel, W
   Nagineni, CN
   Kuty, RK
   Prouty, SM
   Hooks, JJ
   Wiggert, B
TI Regulation of Stearoyl-CoA desaturase expression by transforming growth
   factor-beta (TGF-beta)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NEI, LRCMB, Bethesda, MD 20892 USA.
   NIH, NEI, Bethesda, MD 20892 USA.
   Johnson & Johnson Consumer Prod Inc, Skillman, NJ 08558 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A13
EP A13
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100073
ER

PT J
AU Segal, BM
   Shevach, EM
AF Segal, BM
   Shevach, EM
TI Glioma rejection by a novel collaboration between IL-10 producing CD4+T
   cells and NK cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Rochester, Sch Med & Dent, Rochester, NY 14642 USA.
   NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A657
EP A657
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103772
ER

PT J
AU Seki, N
   Brooks, AD
   Wiltrout, RH
   Sayers, TJ
AF Seki, N
   Brooks, AD
   Wiltrout, RH
   Sayers, TJ
TI Mechanisms of T-cell mediated lysis of a murine renal cancer
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
RI Sayers, Thomas/G-4859-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A656
EP A656
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103767
ER

PT J
AU Selengut, JD
AF Selengut, JD
TI Creating a model for the structure of MDP-1: a structural analysis of
   the haloacid dehalogenase (HAD) superfamily.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Biochem Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A9
EP A9
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100051
ER

PT J
AU Shimozato, O
   Komschlies, KL
   Ortaldo, JR
   Young, HA
AF Shimozato, O
   Komschlies, KL
   Ortaldo, JR
   Young, HA
TI Impaired NK cell development in IFN-gamma transgenic mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A361
EP A361
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102065
ER

PT J
AU Sierra, DA
   Gilbert, D
   Yu, K
   Copeland, N
   Jenkins, N
   Wilkie, TM
AF Sierra, DA
   Gilbert, D
   Yu, K
   Copeland, N
   Jenkins, N
   Wilkie, TM
TI Genomic characterization of the human and mouse RGS multigene family
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Texas, SW Med Ctr, Dallas, TX 75390 USA.
   NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A578
EP A578
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103308
ER

PT J
AU Silver, PB
   Agarwal, RK
   Chan, CC
   Wiggert, B
   Caspi, RR
AF Silver, PB
   Agarwal, RK
   Chan, CC
   Wiggert, B
   Caspi, RR
TI Differential roles for IL-12 and TNF[alpha] in pathogenesis of
   experimental autoimmune uveitis in IFN-[gamma] deficient and wild type
   mice.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A355
EP A355
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102029
ER

PT J
AU Smeltz, RB
   Hu-Li, J
   Shevach, EM
AF Smeltz, RB
   Hu-Li, J
   Shevach, EM
TI Regulation of IL-18 receptor alpha-chain (IL-18R alpha) expression
   during Th1/Th2 differentiation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A347
EP A347
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101986
ER

PT J
AU So, SP
   Li, DW
   Ruan, KH
AF So, SP
   Li, DW
   Ruan, KH
TI Substrate-interaction site in the N-terminal membrane anchor segment of
   thromboxane A(2) synthase by determination of its substrate analog
   conformational changes using high resolution NMR technique
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Texas, Hlth Sci Ctr, Houston, TX USA.
   NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A201
EP A201
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101147
ER

PT J
AU Song, LN
   Rusconi, S
   Simons, SS
AF Song, LN
   Rusconi, S
   Simons, SS
TI Transactivation specificity of glucocorticoid vs. progesterone
   receptors: Role of functionally different interactions with
   transcription factors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK, NIH, Bethesda, MD 20892 USA.
   Univ Fribourg, CH-1700 Fribourg, Switzerland.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A527
EP A527
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103016
ER

PT J
AU Steck-Scott, S
   Lanza, E
   Forman, M
   Sowell, A
   Borkowf, C
   Albert, P
   Schatzkin, A
AF Steck-Scott, S
   Lanza, E
   Forman, M
   Sowell, A
   Borkowf, C
   Albert, P
   Schatzkin, A
CA PPT Study Grp
TI Relationship between serum carotenoids and polyp recurrence: Results
   from the Polyp Prevention Trial
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 4
Z9 4
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A62
EP A62
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100353
ER

PT J
AU Stetler-Stevenson, WG
AF Stetler-Stevenson, WG
TI Direct role of tissue inhibitors of metalloproteinases (TIMPs) in tumor
   cell growth
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, NIH, DCS, Bethesda, MD 20892 USA.
RI Stetler-Stevenson, William/H-6956-2012
OI Stetler-Stevenson, William/0000-0002-5500-5808
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A23
EP A23
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100127
ER

PT J
AU Stolzenberg-Solomon, RZ
   Pietinen, P
   Taylor, PR
   Virtamo, J
   Albanes, D
AF Stolzenberg-Solomon, RZ
   Pietinen, P
   Taylor, PR
   Virtamo, J
   Albanes, D
TI A prospective study of diet and pancreatic cancer in male smokers.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
   Natl Publ Hlth Inst, Helsinki, Finland.
RI Albanes, Demetrius/B-9749-2015
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A62
EP A62
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100350
ER

PT J
AU Sueyoshi, T
   Sugatani, J
   Kojima, H
   Ueda, A
   Kakizaki, S
   Yoshinari, K
   Gong, QH
   Owens, IS
   Negishi, M
AF Sueyoshi, T
   Sugatani, J
   Kojima, H
   Ueda, A
   Kakizaki, S
   Yoshinari, K
   Gong, QH
   Owens, IS
   Negishi, M
TI The nuclear receptor CAR activates phenobarbital response enhancer
   module in UGT1A1, the human bilirubin UDP-glucuronosyltransfererase gene
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
   NICHD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A526
EP A526
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103007
ER

PT J
AU Szalai, AJ
   Cooper, GS
   McCrory, MA
   Kimberly, RP
AF Szalai, AJ
   Cooper, GS
   McCrory, MA
   Kimberly, RP
TI Association between a GT-repeat polymorphism in the intron of the
   C-reactive protein (CRP) gene and plasma CRP.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Alabama, Birmingham, AL 35294 USA.
   NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A685
EP A685
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103933
ER

PT J
AU Taylor, LS
   McVicar, DW
AF Taylor, LS
   McVicar, DW
TI Proteasome-dependent, CBL-independent regulation of DAP12-mediated
   signaling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A707
EP A707
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104063
ER

PT J
AU Tcherkasskaya, O
   Gronenborn, AM
AF Tcherkasskaya, O
   Gronenborn, AM
TI Fluorescence energy transfer for the study of biological structures.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NCI, Mol Struct Sect, Bethesda, MD 20892 USA.
   NIH, NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A535
EP A535
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103059
ER

PT J
AU Thornton, AM
   Shevach, EM
AF Thornton, AM
   Shevach, EM
TI Engagement of CD28/CTLA-4 is not required for activation of
   CD4+CD25+suppressor effector function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A350
EP A350
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102001
ER

PT J
AU Tian, WZ
   Mcintyre, T
   Strober, W
   Chu, CC
AF Tian, WZ
   Mcintyre, T
   Strober, W
   Chu, CC
TI Identification of genes expressed in B cells undergoing class switch
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 N Shore Univ Hosp, Manhasset, NY 11030 USA.
   NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A695
EP A695
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103994
ER

PT J
AU Tong, HY
   Steenbergen, C
   Murphy, E
AF Tong, HY
   Steenbergen, C
   Murphy, E
TI Role of glycogen synthase kinase-3 beta in the phosphatidylinositol
   3-kinase signaling pathway in ischemic preconditioning
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
   Duke Univ, Med Ctr, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A461
EP A461
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102635
ER

PT J
AU Trouba, KJ
   Germolec, DR
AF Trouba, KJ
   Germolec, DR
TI Differential sensitivity of human and murine keratincoytes to the
   proliferation enhancing effects of sodium arsenite
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A221
EP A221
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101261
ER

PT J
AU Tsao, CC
   Chien, A
   Couler, SJ
   Maronpot, R
   Roberts, JE
   Goldstein, JA
AF Tsao, CC
   Chien, A
   Couler, SJ
   Maronpot, R
   Roberts, JE
   Goldstein, JA
TI Identification of CYP2Cs in murine eyes and human retinal epithelial
   cells and investigation of their roles with respect to UV-B damage
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, Lab Pharmacol & Chem, Res Triangle Pk, NC 27709 USA.
   NIEHS, Lab Expt Pathol, Res Triangle Pk, NC 27709 USA.
   Fordham Univ, New York, NY 10023 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A181
EP A181
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101030
ER

PT J
AU Tuaillon, N
   Shen, D
   Berger, RB
   Lu, B
   Rollins, BJ
   Chan, CC
AF Tuaillon, N
   Shen, D
   Berger, RB
   Lu, B
   Rollins, BJ
   Chan, CC
TI Lack of lipopolysaccharide-induced ocular inflammation in MCP-1
   deficient mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NEI, Bethesda, MD 20892 USA.
   Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A361
EP A361
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102069
ER

PT J
AU Urban, JF
   Schopf, L
   Madden, KB
   Noben-Trauth, N
   Finkelman, FD
AF Urban, JF
   Schopf, L
   Madden, KB
   Noben-Trauth, N
   Finkelman, FD
TI Nematode biology determines the requirement for expression of IL-4
   receptor (R)alpha chain on lymphoid and/or non-lymphoid cells that
   regulate intestinal expulsion.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 USDA, Beltsville, MD 20705 USA.
   USUHS, Bethesda, MD USA.
   NIH, NIAID, Rockville, MD USA.
   Univ Cincinnati, Coll Med, Cincinnati, OH 45220 USA.
NR 0
TC 1
Z9 1
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A690
EP A690
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103963
ER

PT J
AU Varesio, L
   Melillo, G
   Pastorino, S
   Rapisarda, A
   Bosco, MC
AF Varesio, L
   Melillo, G
   Pastorino, S
   Rapisarda, A
   Bosco, MC
TI Hypoxia and macrophages
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Ist Giannina Gaslini, I-16148 Genoa, Italy.
   NCI, Frederick Canc Res & Dev Ctr, DTP, Tumor Hypoxia Program, Frederick, MD 21702 USA.
RI Bosco, Maria Carla/J-7928-2016; varesio, luigi/J-8261-2016
OI Bosco, Maria Carla/0000-0003-1857-7193; varesio,
   luigi/0000-0001-5659-2218
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A156
EP A156
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100890
ER

PT J
AU Vu, CC
   Wallace, AD
   Cidlowski, JA
AF Vu, CC
   Wallace, AD
   Cidlowski, JA
TI Induction of lymphocyte apoptosis by inhibition of proteasome function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A508
EP A508
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102904
ER

PT J
AU Wang, J
   Whitman, MC
   Natarajan, K
   Tormo, J
   Mariuzza, RA
   Margulies, DH
AF Wang, J
   Whitman, MC
   Natarajan, K
   Tormo, J
   Mariuzza, RA
   Margulies, DH
TI Mutational analysis of binding of the NK inhibitory receptor Ly49A to
   its H-2Dd ligand: evidence for both local and global effects on Lg49A
   structure.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
   Univ Autonoma Madrid, Madrid, Spain.
   Univ Maryland, Rockville, MD 20850 USA.
RI Margulies, David/H-7089-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A321
EP A321
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101833
ER

PT J
AU Wang, JM
   Le, YY
   Oppenheim, J
AF Wang, JM
   Le, YY
   Oppenheim, J
TI The involvement of the G-protein coupled receptor FPRL1 in
   proinflammatory aspects of Alzheimer's disease
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A682
EP A682
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103918
ER

PT J
AU Wang, SQ
   Cheng, HP
AF Wang, SQ
   Cheng, HP
TI Intermolecular coupling between single L-type Ca2+ channels and
   ryanodine receptors in cardiac myocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A491
EP A491
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102807
ER

PT J
AU Wang, SQ
   Zhou, ZQ
AF Wang, SQ
   Zhou, ZQ
TI Intracellular calcium homeostasis in cardiac cells during deep
   hypothermia: A comparative study
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA, Baltimore, MD 21224 USA.
   Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A410
EP A410
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102340
ER

PT J
AU Wange, RL
   Balakir, R
   Shan, XC
AF Wange, RL
   Balakir, R
   Shan, XC
TI ZAP-70-independent Erk activation in Jurkat T cells by TCR engagement
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Baltimore, MD 21224 USA.
   Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A702
EP A702
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438104032
ER

PT J
AU Weinstein, SJ
   Shipman, AM
   Ziegler, RG
AF Weinstein, SJ
   Shipman, AM
   Ziegler, RG
TI Serum vitamin C is not associated with invasive cervical cancer risk.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A615
EP A615
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103526
ER

PT J
AU Williams, WM
   Moskovitz, J
   Stadtman, E
AF Williams, WM
   Moskovitz, J
   Stadtman, E
TI Effect of age and hyperoxia on thioredoxin levels in cerebral
   microvessels and brain of the C57Bl/6J mouse
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A383
EP A383
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102191
ER

PT J
AU Woolhiser, MR
   Gilfillan, AM
   Okayama, Y
   Metcalfe, DD
AF Woolhiser, MR
   Gilfillan, AM
   Okayama, Y
   Metcalfe, DD
TI Activation of human mast cells via Fc gamma RI crosslinking by
   aggregated IgG(1) complexes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A334
EP A334
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101910
ER

PT J
AU Yoshimoto, T
   Tsutsui, H
   Okamura, H
   Mizutani, H
   Noben-Trauth, N
   Paul, WE
   Nakanishi, K
AF Yoshimoto, T
   Tsutsui, H
   Okamura, H
   Mizutani, H
   Noben-Trauth, N
   Paul, WE
   Nakanishi, K
TI IL-18 induces IgE production in wild type and caspase-1 transgenic mice:
   dependence on CD4(+) T cells, IL-4 and Stat6.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Hyogo Coll Med, Nishinomiya, Hyogo 6638501, Japan.
   Mie Univ, Tsu, Mie 5148507, Japan.
   NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A347
EP A347
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438101985
ER

PT J
AU Youssef, JA
   Ammann, P
   Ghanayem, BI
   Birnbaum, LS
   Badr, MZ
AF Youssef, JA
   Ammann, P
   Ghanayem, BI
   Birnbaum, LS
   Badr, MZ
TI Discordant induction of peroxisome proliferator-activated receptor alpha
   mRNA and dependent genes by peroxisome proliferators in livers of
   senescent rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 Univ Missouri, Kansas City, MO 64108 USA.
   NIEHS, Res Triangle Pk, NC 27709 USA.
   US EPA, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A562
EP A562
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103218
ER

PT J
AU Zhang, WL
   Gomeza, J
   Basile, AS
   Wess, J
AF Zhang, WL
   Gomeza, J
   Basile, AS
   Wess, J
TI Analysis of cortical, hippocampal, and striatal muscarinic inhibitory
   autoreceptors by the use of muscarinic acetylcholine receptor knockout
   mice.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A558
EP A558
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438103193
ER

PT J
AU Zhang, X
   Shimozato, O
   Young, HA
AF Zhang, X
   Shimozato, O
   Young, HA
TI The natural ligand for PPAR-gamma-15-deoxy-Delta(12.14) prostaglandin
   J(2)-represses interferon-gamma production by NK cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, NCI, Frederick, MD 21702 USA.
RI Young, Howard/A-6350-2008; Zhang, Xia/B-8152-2008
OI Young, Howard/0000-0002-3118-5111; Zhang, Xia/0000-0002-9040-1486
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A361
EP A361
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438102067
ER

PT J
AU Zhang, Y
   Dufau, M
AF Zhang, Y
   Dufau, M
TI Hormonal control of rat luteinizing hormone receptor regulated
   transcription by nuclear orphan receptors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 7
PY 2001
VL 15
IS 4
BP A7
EP A7
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410KA
UT WOS:000167438100038
ER

PT J
AU Kim, G
   Lee, TH
   Wynshaw-Boris, A
   Levine, RL
AF Kim, G
   Lee, TH
   Wynshaw-Boris, A
   Levine, RL
TI Nucleotide sequence and structure of the mouse carbonic anhydrase III
   gene
SO GENE
LA English
DT Article
DE carbonic anhydrase; pyrimidine rich 5 ' flanking region
ID GAGA TRANSCRIPTION FACTOR; S-THIOLATION; SKELETAL-MUSCLE; EXPRESSION;
   DNA; PROTEIN; TISSUES; SULFHYDRYLS; CHROMATIN; REQUIRES
AB At least 14 distinct isozymes of carbonic anhydrase have been identified in mammals. These enzymes catalyze the hydration of carbon dioxide and are essential for regulation of cellular pH and carbon dioxide transport. Carbonic anhydrase III is highly expressed in certain tissues, including muscle and fat where it constitutes up to 25% of the soluble protein. We cloned a cDNA encoding mouse carbonic anhydrase III. This cDNA contains 1653 bp, consisting of 79 bp in the 5' UTR, a 780 bp open reading frame, and 794 bp of the 3' UTR, including two potential polyadenylation signals. Fluorescent in situ hybridization confirmed the existence of a single copy of the gene on chromosome 3. We then isolated the genomic DNA for mouse carbonic anhydrase III and analyzed its structure. The gene consists of seven exons and six introns which spun 10.5 kb. The 5' flanking region of the genomic DNA is notable for a pyrimidine rich region consisting of two dinucleotide repeats containing 23 and 20 TC pairs separated by the same 15 bp spacer. Published by Elsevier Science B.V.
C1 NHLBI, Biochem Lab, NIH, Bethesda, MD 20892 USA.
   NHLBI, Lab Cell Signaling, NIH, Bethesda, MD 20892 USA.
   NHGRI, Lab Genet Dis Res, NIH, Bethesda, MD 20892 USA.
RP Kim, G (reprint author), NHLBI, Biochem Lab, NIH, Bldg 3, Bethesda, MD 20892 USA.
RI Levine, Rodney/D-9885-2011
NR 31
TC 5
Z9 6
U1 1
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD MAR 7
PY 2001
VL 265
IS 1-2
BP 37
EP 44
DI 10.1016/S0378-1119(01)00355-9
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 415WX
UT WOS:000167747500004
PM 11255005
ER

PT J
AU Yerushalmi, N
   Keppler-Hafkemeyer, A
   Vasmatzis, G
   Liu, XF
   Olsson, P
   Bera, TK
   Duray, P
   Lee, B
   Pastan, I
AF Yerushalmi, N
   Keppler-Hafkemeyer, A
   Vasmatzis, G
   Liu, XF
   Olsson, P
   Bera, TK
   Duray, P
   Lee, B
   Pastan, I
TI ERGL, a novel gene related to ERGIC-53 that is highly expressed in
   normal and neoplastic prostate and several other tissues
SO GENE
LA English
DT Article
DE EST's data mining; prostate cancer; alternate splicing; in situ
   hybridization
ID DISCOVERY; DATABASE; SEQUENCE
AB We have identified a new gene, that is highly expressed in normal and neoplastic prostate, and is also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS. Database analyses of ESTs indicated prostate specificity but experimental results showed the expression in other tissues. The full length transcript is 1800 bp with an open reading frame of 526 aa. The amino-terminal 230 residues of the expressed protein has high homology to a family of lectins, especially to the sugar binding domain of ERGIC-53. We therefore designate the new gene ERGL (ERGIC-53-like). There is a transmembrane domain at amino acid positions 468-482 suggesting that the product of ERGL is a type-I membrane protein. In prostate there are two fully processed transcripts one of which is a splice variant with a deletion in the region of the transmembrane domain of the protein. (C) 2001 Elsevier Science B.V. All rights reserved.
C1 NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
   NCI, Inst Clin Sci, NIH, Bethesda, MD 20892 USA.
RP Pastan, I (reprint author), NCI, Mol Biol Lab, NIH, 37-4E16,37 Convent Dr MSC 4255, Bethesda, MD 20892 USA.
NR 11
TC 18
Z9 20
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD MAR 7
PY 2001
VL 265
IS 1-2
BP 55
EP 60
DI 10.1016/S0378-1119(01)00347-X
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 415WX
UT WOS:000167747500006
PM 11255007
ER

PT J
AU Gail, MH
   Costantino, JP
AF Gail, MH
   Costantino, JP
TI Validating and improving models for projecting the absolute risk of
   breast cancer
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Editorial Material
ID FAMILY HISTORY; WOMEN; TAMOXIFEN; BRCA1
C1 NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
   Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA.
RP Gail, MH (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, EPS-8032, Bethesda, MD 20892 USA.
NR 19
TC 70
Z9 70
U1 0
U2 2
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 7
PY 2001
VL 93
IS 5
BP 334
EP 335
DI 10.1093/jnci/93.5.334
PG 2
WC Oncology
SC Oncology
GA 407UE
UT WOS:000167288500001
PM 11238688
ER

PT J
AU Hoffman, RM
   Gilliland, FD
   Eley, JW
   Harlan, LC
   Stephenson, RA
   Stanford, JL
   Albertson, PC
   Hamilton, AS
   Hunt, WC
   Potosky, AL
AF Hoffman, RM
   Gilliland, FD
   Eley, JW
   Harlan, LC
   Stephenson, RA
   Stanford, JL
   Albertson, PC
   Hamilton, AS
   Hunt, WC
   Potosky, AL
TI Racial and ethnic differences in advanced-stage prostate cancer: the
   prostate cancer outcomes study
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article; Proceedings Paper
CT 22nd Annual Meeting of the Society-of-General-Internal-Medicine
CY APR 29-MAY 01, 1999
CL SAN FRANCISCO, CALIFORNIA
SP Soc Gen Internal Med
ID AFRICAN-AMERICAN MEN; DETROIT METROPOLITAN-AREA; BLACK-WHITE
   DIFFERENCES; DATA-BASE REPORT; RADICAL PROSTATECTOMY; UNITED-STATES;
   SURVIVAL; RACE; CARCINOMA; DIAGNOSIS
AB Background: African-Americans have twice the risk of non-Hispanic whites for presenting with advanced-stage prostate cancer. To investigate the reasons for this difference, we evaluated the association between race/ ethnicity and advanced-stage prostate cancer, adjusting for demographic, socioeconomic, clinical, and pathologic factors. Methods: A population-based cohort of 3173 men diagnosed with prostate cancer between October 1, 1994, and October 31, 1995, was analyzed. Medical record abstracts and self-administered survey questionnaires were used to obain information regarding race/ethnicity, age, marital status, insurance status, educational level, household income, employment status, comorbidity, urinary function, prostate-specific antigen level, tumor grade, and clinical stage. The odds ratio (OR) for advanced-stage prostate cancer was estimated with weighted logistic regression analysis. All P values were two-sided. Results: Clinically advanced-stage prostate cancers were detected more frequently in African-Americans (12.3%) and Hispanics (10.5%) than in non-Hispanic whites (6.3%). Socioeconomic, clinical, and pathologic factors each accounted for about 15% of the increased relative risk. After adjusting for all covariates, the risk remained statistically significantly increased for African-Americans (OR = 2.26; 95% confidence interval [CI] = 1.43 to 3.58) but not for Hispanics (OR = 1.23; 95% CI = 0.73 to 2.08). Conclusion: Traditional socioeconomic, clinical, and pathologic factors accounted for the increased relative risk for presenting with advanced-stage prostate cancer in Hispanic but not in African-American men.
C1 Dept Vet Affairs Med Ctr, Med Serv, Albuquerque, NM 87108 USA.
   Univ New Mexico, New Mexico Tumor Registry, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
   Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   Emory Univ, Rollins Sch Publ Hlth, Georgia Ctr Canc Stat, Atlanta, GA 30322 USA.
   NCI, Div Canc Control & Prevent, Bethesda, MD 20892 USA.
   Univ Utah, Sch Med, Div Urol, Salt Lake City, UT USA.
   Univ Utah, Sch Med, Utah Canc Registry, Salt Lake City, UT USA.
   Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
   Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   Univ Connecticut, Hlth Sci Ctr, Div Urol, Farmington, CT USA.
RP Hoffman, RM (reprint author), Dept Vet Affairs Med Ctr, Med Serv, 1501 San Pedro Dr SE, Albuquerque, NM 87108 USA.
FU NCI NIH HHS [N01CN67009, N01PC67000, N01PC67005, N01PC67006, N01PC67007,
   N01PC67010]
NR 49
TC 207
Z9 211
U1 3
U2 6
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 7
PY 2001
VL 93
IS 5
BP 388
EP 395
DI 10.1093/jnci/93.5.388
PG 8
WC Oncology
SC Oncology
GA 407UE
UT WOS:000167288500013
PM 11238701
ER

PT J
AU Chen, TT
   Chute, JP
   Feigal, E
   Johnson, BE
   Simon, R
AF Chen, TT
   Chute, JP
   Feigal, E
   Johnson, BE
   Simon, R
TI Re: A model to select chemotherapy regimens for phase III trials for
   extensive-stage small-cell lung cancer - Response
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Letter
C1 Univ Maryland, Greenebaum Canc Ctr, Biostat Sect, Div Canc Treatment & Diag, Baltimore, MD 21201 USA.
   NCI, Biometr Res Branch, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   Natl Naval Med Ctr, Naval Med Res Ctr, Bethesda, MD USA.
   Natl Naval Med Ctr, Div Hematol Oncol, Bethesda, MD USA.
   Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA.
RP Chen, TT (reprint author), Univ Maryland, Greenebaum Canc Ctr, Biostat Sect, Div Canc Treatment & Diag, 22 S Greene St, Baltimore, MD 21201 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 7
PY 2001
VL 93
IS 5
BP 400
EP 401
DI 10.1093/jnci/93.5.400
PG 2
WC Oncology
SC Oncology
GA 407UE
UT WOS:000167288500020
ER

PT J
AU Potosky, AL
   Legler, J
   Hoffman, RM
   Gilliland, FD
AF Potosky, AL
   Legler, J
   Hoffman, RM
   Gilliland, FD
TI Re: Health outcomes after prostatectomy or radiotherapy for prostate
   cancer: Results from the Prostate Cancer Outcomes Study - Response
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Letter
ID QUALITY-OF-LIFE; SEXUAL FUNCTION; RECALL
C1 NCI, Appl Res Program, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
RP Potosky, AL (reprint author), NCI, Appl Res Program, Div Canc Control & Populat Sci, NIH, EPN,Rm 4005,6130 Execut Blvd,MSC 7344, Bethesda, MD 20892 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 7
PY 2001
VL 93
IS 5
BP 401
EP 402
PG 2
WC Oncology
SC Oncology
GA 407UE
UT WOS:000167288500022
ER

PT J
AU Gray, T
   Koo, JS
   Nettesheim, P
AF Gray, T
   Koo, JS
   Nettesheim, P
TI Regulation of mucous differentiation and mucin gene expression in the
   tracheobronchial epithelium
SO TOXICOLOGY
LA English
DT Article
DE mucin gene expression; mucous differentiation; tracheobronchial
   epithelium
ID EPIDERMAL GROWTH-FACTOR; RETINOIC ACID; FACTOR RECEPTOR; MUC5B MUCIN;
   CELLS; IDENTIFICATION; PHENOTYPE; GLYCOFORMS; SYNTHASE; BINDING
AB The goal of our studies is to elucidate mechanisms that control and modulate mucous differentiation and mucin gene expression in the conducting airways. We used cultures of normal human tracheobronchial epithelial (NHTBE) cells that were shown to secrete two major airway mucins, namely MUC5AC and MUC5B as well as several other secretory products. Mucous differentiation and expression of MUC2, MUC5AC, MUC5B and MUC7, but not MUCi, MUC4, and MUC8 mucin genes, were shown to be retinoic acid- (RA) or retinol-dependent. We found that RA control of mucin genes was mediated by the retinoid acid receptors RAR alpha and, to a lesser extent, by RAR gamma Our studies also showed that other important bioregulators such as thyroid hormone (T-3) and epidermal growth factor (EGF) modulate basal expression of mucin genes, interacting with RA in a concentration-dependent manner. T-3, which binds to thyroid receptors (TRs) belonging to the same superfamily of steroid hormone nuclear receptors as the RARs, inhibits mucin gene expression, particularly MUCSAC. One possible mechanism of this T-3 effect is downregulation of RAR proteins, which are critical for mucin gene expression. However, we also found that T-3 inhibits MUC5AC transcription.
   EGF, which had previously been shown to stimulate mucin expression and mucin secretion in cultured rat tracheal epithelial (RTE) cells, inhibited mucin secretion in human bronchial epithelial cell cultures. This effect was EGF concentration- and time-dependent and was progressively abolished by increasing the RA concentration. Subsequent studies suggested that the inhibitory effects of high. concentrations of EGF may result from selective reduction of MUCSAC expression. These studies thus point to potentially important species differences in the mechanisms regulating mucous production, and they also confirm previous findings indicating differential regulation of MUCSAC and MUCSB gene expression. Published by Elsevier Science Ireland Ltd.
C1 NIEHS, Pulm Pathobiol Lab, Res Triangle Pk, NC 27709 USA.
RP Gray, T (reprint author), NIEHS, Pulm Pathobiol Lab, POB 12233, Res Triangle Pk, NC 27709 USA.
NR 37
TC 55
Z9 57
U1 0
U2 5
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD MAR 7
PY 2001
VL 160
IS 1-3
SI SI
BP 35
EP 46
DI 10.1016/S0300-483X(00)00455-8
PG 12
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 414WH
UT WOS:000167688800006
PM 11246122
ER

PT J
AU Franklin, SS
   Larson, MC
   Khan, SA
   Wong, ND
   Leip, EP
   Kannel, WB
   Levy, D
AF Franklin, SS
   Larson, MC
   Khan, SA
   Wong, ND
   Leip, EP
   Kannel, WB
   Levy, D
TI Does the relation of blood pressure to coronary heart disease risk
   change with aging? The Framingham Heart Study
SO CIRCULATION
LA English
DT Article
DE blood pressure; hypertension; pulse pressure; coronary disease
ID ISOLATED SYSTOLIC HYPERTENSION; CARDIOVASCULAR MORTALITY; PREDICTORS
AB Background-We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age groups of Framingham Heart Study participants.
   Methods and Results-We studied 3060 men and 3479 women between 20 and 79 years of age who were free of CHD and were not on antihypertensive drug therapy at baseline. Cox regression adjusted for age, sex, and other risk factors was used to assess the relations of BP indexes to CHD risk over a 20-year follow-up. In the group <50 years of age, DBP was the strongest predictor of CHD risk (hazard ratio [HR] per 10 mm Hg increment, 1.34; 95% CI, 1.18 to 1.51) rather than SBP (HR, 1.14; 95% CI, 1.06 to 1.24) or PP (HR, 1.02; 95% CI, 0.89 to 1.17). In the group 50 to 59 years of age, risks were comparable for all 3 BP indexes. In the older age group, the strongest predictor of CHD risk was PP (HR, 1.24; 95% CI, 1.16 to 1.33). When both SEP and DBP were considered jointly, the former was directly and the latter was inversely related to CHD risk in the oldest age group.
   Conclusions-With increasing age, there was a gradual shift from DBP to SEP and then to PP as predictors of CHD risk. In patients <50 years of age, DBP was the strongest predictor. Age 50 to 59 years was a transition period when all 3 BP indexes were comparable predictors, and from 60 years of age on, DBP was negatively related to CHD risk so that PP became superior to SEP.
C1 Univ Calif Irvine, Prevent Cardiol Program, Irvine, CA 92697 USA.
   NHLBI, Framingham Heart Study, Framingham, MA USA.
   NHLBI, Bethesda, MD 20892 USA.
   Boston Univ, Sch Med, Dept Epidemiol & Biostat, Boston, MA 02118 USA.
RP Franklin, SS (reprint author), Univ Calif Irvine, UCI Heart Dis Prevent Program, C240 Med Sci, Irvine, CA 92697 USA.
FU NHLBI NIH HHS [N01-HC- 38038]
NR 33
TC 643
Z9 707
U1 4
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
BP 1245
EP 1249
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200013
PM 11238268
ER

PT J
AU Chambless, LE
   Folsom, AR
   Davis, V
   Sharrett, R
   Heiss, G
   Szklo, M
   Evans, GW
AF Chambless, LE
   Folsom, AR
   Davis, V
   Sharrett, R
   Heiss, G
   Szklo, M
   Evans, GW
TI Risk factors for progression of common carotid atherosclerosis: The ARIC
   study 1987-1998
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC 27515 USA.
   Univ Minnesota, Minneapolis, MN 55455 USA.
   NHLBI, Bethesda, MD 20892 USA.
   Johns Hopkins Univ, Baltimore, MD USA.
   Wake Forest Univ, Winston Salem, NC 27109 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0005
BP 1344
EP 1345
PG 2
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200033
ER

PT J
AU Meigs, JB
   Larson, MG
   D'Agostino, RB
   Levy, D
   Clouse, ME
   Nathan, DM
   Wilson, PWF
   O'Donnell, CJ
AF Meigs, JB
   Larson, MG
   D'Agostino, RB
   Levy, D
   Clouse, ME
   Nathan, DM
   Wilson, PWF
   O'Donnell, CJ
TI Coronary artery calcification in type 2 diabetes and insulin resistance:
   the Framingham Offspring Study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Framingham, MA USA.
   Boston Univ, Boston, MA 02215 USA.
   Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
   Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Boston Univ, Framingham, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0002
BP 1344
EP 1344
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200030
ER

PT J
AU Kimm, SYS
   Glynn, NW
   Barton, BA
   Kronsberg, SS
   Schreiber, GB
   Daniels, SR
   Obarzanek, E
AF Kimm, SYS
   Glynn, NW
   Barton, BA
   Kronsberg, SS
   Schreiber, GB
   Daniels, SR
   Obarzanek, E
TI The association of physical activity with obesity development during
   adolescence: NHLBI Growth and Health Study (NGHS)
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   Maryland Med Res Inst, Baltimore, MD USA.
   Westat Inc, Rockville, MD USA.
   Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA.
   NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0006
BP 1345
EP 1345
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200034
ER

PT J
AU Psaty, BM
   Smith, NL
   Manolio, TA
   Heckbert, SR
   Gottdiener, JS
   Burke, GL
   Powe, NR
   Weissfeld, JL
   Enright, P
   Furberg, CD
AF Psaty, BM
   Smith, NL
   Manolio, TA
   Heckbert, SR
   Gottdiener, JS
   Burke, GL
   Powe, NR
   Weissfeld, JL
   Enright, P
   Furberg, CD
TI The incidence of treated hypertension and time trends in the use of
   antihypertensive medications in older adults
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Washington, Seattle, WA 98195 USA.
   NHLBI, Bethesda, MD 20892 USA.
   Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
   Wake Forest Univ, Winston Salem, NC 27109 USA.
   Johns Hopkins Univ, Baltimore, MD USA.
   Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   Univ Arizona, Tucson, AZ USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0011
BP 1346
EP 1346
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200039
ER

PT J
AU Rosamond, WD
   Sullivan, MD
   Chambless, LE
   Wang, CH
   Cooper, LS
   Folsom, AR
AF Rosamond, WD
   Sullivan, MD
   Chambless, LE
   Wang, CH
   Cooper, LS
   Folsom, AR
TI Survival after treatment during hospitalization for acute myocardial
   infarction: A community-based perspective
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC 27515 USA.
   Stanford Univ, Palo Alto, CA 94304 USA.
   NIH, Bethesda, MD 20892 USA.
   Univ Minnesota, Minneapolis, MN 55455 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0010
BP 1346
EP 1346
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200038
ER

PT J
AU Jones, DW
   Chambless, LE
   Folsom, AR
   Heiss, G
   Hutchinson, RG
   Sharrett, RA
   Szklo, M
   Tyroler, HA
   Taylor, HA
AF Jones, DW
   Chambless, LE
   Folsom, AR
   Heiss, G
   Hutchinson, RG
   Sharrett, RA
   Szklo, M
   Tyroler, HA
   Taylor, HA
TI CHD risk factors in African-Americans
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Mississippi, Med Ctr, Jackson, MS 39216 USA.
   Univ N Carolina, Chapel Hill, NC USA.
   Univ Minnesota, Minneapolis, MN USA.
   NHLBI, Bethesda, MD 20892 USA.
   Johns Hopkins Univ, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0017
BP 1347
EP 1347
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200045
ER

PT J
AU Pahor, M
   Kritchevsky, SB
   Tracy, RP
   Newman, AB
   Di Bari, M
   Williamson, JD
   Harris, TB
   Cummings, SR
AF Pahor, M
   Kritchevsky, SB
   Tracy, RP
   Newman, AB
   Di Bari, M
   Williamson, JD
   Harris, TB
   Cummings, SR
TI Interleukin-6 and heart rate in a population-based sample: the Health
   ABC study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Wake Forest Univ, Winston Salem, NC 27109 USA.
   Univ Tennessee, Memphis, TN USA.
   Univ Vermont, Burlington, VT USA.
   Univ Pittsburgh, Pittsburgh, PA USA.
   NIA, Bethesda, MD 20892 USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
RI DI BARI, MAURO/J-1524-2012; Newman, Anne/C-6408-2013
OI Newman, Anne/0000-0002-0106-1150
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0022
BP 1348
EP 1348
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200050
ER

PT J
AU Rose, KM
   Holme, I
   Light, KC
   Sharrett, AR
   Tyroler, HA
AF Rose, KM
   Holme, I
   Light, KC
   Sharrett, AR
   Tyroler, HA
TI The association between orthostatic hypotension and the six-year
   incidence of hypertension: the Atherosclerosis Risk in Communities study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC 27515 USA.
   Life Insurance Co, Inst Med Stat, Oslo, Norway.
   NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0020
BP 1348
EP 1348
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200048
ER

PT J
AU Manolio, TA
   Cushman, M
   Gottdiener, JS
   Dobs, A
   Kuller, LH
   Kronmal, RA
AF Manolio, TA
   Cushman, M
   Gottdiener, JS
   Dobs, A
   Kuller, LH
   Kronmal, RA
TI Predictors of falling cholesterol levels in older adults: The
   cardiovascular health study.
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Bethesda, MD 20892 USA.
   Univ Vermont, Colchester, VT USA.
   St Francis Hosp, Roslyn, NY USA.
   Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
   Univ Pittsburgh, Pittsburgh, PA USA.
   Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA 0028
BP 1349
EP 1349
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200056
ER

PT J
AU O'Donnell, CJ
   Benjamin, EJ
   Corey, D
   Newton-Cheh, C
   Levy, D
   D'Agostino, RB
   Larson, MG
AF O'Donnell, CJ
   Benjamin, EJ
   Corey, D
   Newton-Cheh, C
   Levy, D
   D'Agostino, RB
   Larson, MG
TI The PR interval is a heritable quantitative trait with evidence for
   linkage to chromosome 4 in a genome-wide scan: The Framingham Heart
   Study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Framingham Heart Study, Framingham, MA USA.
   Boston Univ, Med Ctr, Framingham, MA USA.
   Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Boston Univ, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P19
BP 1354
EP 1354
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200079
ER

PT J
AU Siervogel, RM
   Czerwinski, SA
   Maynard, LM
   Wilson, AF
   Demerath, EE
   Guo, SS
   Rogers, N
   Towne, B
AF Siervogel, RM
   Czerwinski, SA
   Maynard, LM
   Wilson, AF
   Demerath, EE
   Guo, SS
   Rogers, N
   Towne, B
TI Genetic analysis of blood pressure and blood pressure response to
   orthostatic stress: are the same genes involded in both traits?
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Wright State Univ, Sch Med, Kettering, OH USA.
   NHGRI, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P20
BP 1354
EP 1354
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200080
ER

PT J
AU Pahor, M
   Kritchevsky, SB
   Tracy, RP
   Newman, AB
   Sutton-Tyrrell, K
   Carosella, L
   Onder, G
   Simonsick, EM
   Harris, TB
   Penninx, BBWJH
AF Pahor, M
   Kritchevsky, SB
   Tracy, RP
   Newman, AB
   Sutton-Tyrrell, K
   Carosella, L
   Onder, G
   Simonsick, EM
   Harris, TB
   Penninx, BBWJH
TI Inflammatory markers, clinical and subclinical cardiovascular disease in
   older persons: the Health ABC study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Wake Forest Univ, Winston Salem, NC 27109 USA.
   Univ Tennessee, Memphis, TN USA.
   Univ Vermont, Burlington, VT USA.
   Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
   NIA, Bethesda, MD 20892 USA.
RI Newman, Anne/C-6408-2013
OI Newman, Anne/0000-0002-0106-1150
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P37
BP 1358
EP 1358
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200097
ER

PT J
AU Kaplan, RC
   Heckbert, SR
   Koepsell, TD
   Rosendaal, FR
   Furberg, CD
   Cooper, LS
   Psaty, BM
AF Kaplan, RC
   Heckbert, SR
   Koepsell, TD
   Rosendaal, FR
   Furberg, CD
   Cooper, LS
   Psaty, BM
TI Calcium channel blocker use and gastrointestinal tract bleeding among
   older adults
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Albert Einstein Coll Med, Bronx, NY 10467 USA.
   Univ Washington, Seattle, WA 98195 USA.
   Leiden Univ, Med Ctr, Leiden, Netherlands.
   Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA.
   NHLBI, Bethesda, MD 20892 USA.
RI Kaplan, Robert/A-2526-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P56
BP 1361
EP 1361
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200116
ER

PT J
AU Taylor, HA
   Brown, AC
   Burchfiel, CM
   Jones, DW
   Skelton, TN
   Arnett, DK
   Clemons, TL
   Clark, BL
   Criqui, MH
AF Taylor, HA
   Brown, AC
   Burchfiel, CM
   Jones, DW
   Skelton, TN
   Arnett, DK
   Clemons, TL
   Clark, BL
   Criqui, MH
TI Pulse pressure and prevalence of peripheral arterial disease: The
   atherosclerosis risk in communities (ARIC) study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Mississippi, Med Ctr, Jackson, MS 39216 USA.
   NHLBI, Jackson, MS USA.
   Univ Minnesota, Minneapolis, MN 55455 USA.
   EMMES Corp, Potomac, MD USA.
   Univ Calif San Diego, San Diego, CA 92103 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P55
BP 1361
EP 1361
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200115
ER

PT J
AU Williamson, JD
   Penninx, B
   DiBari, M
   Fried, LP
   Guralnik, JM
   Pahor, M
AF Williamson, JD
   Penninx, B
   DiBari, M
   Fried, LP
   Guralnik, JM
   Pahor, M
TI Blood pressure control & incident disability in older women: Data from
   the Women's Health and Aging Study.
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA.
   Johns Hopkins Univ, Baltimore, MD USA.
   NIA, Bethesda, MD 20892 USA.
   Wake Forest Univ, Winston Salem, NC 27109 USA.
RI DI BARI, MAURO/J-1524-2012
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P54
BP 1361
EP 1361
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200114
ER

PT J
AU Rathore, SS
   Rosamond, WD
   Cooper, LS
   Chambless, LE
   Tyroler, HA
   Hinn, AR
AF Rathore, SS
   Rosamond, WD
   Cooper, LS
   Chambless, LE
   Tyroler, HA
   Hinn, AR
TI Characterization of stroke signs and symptoms: Findings from the
   Atherosclerosis Risk in Communities study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
   NHLBI, Bethesda, MD 20892 USA.
   Univ N Carolina, Sch Med, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P59
BP 1362
EP 1362
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200119
ER

PT J
AU Shahar, E
   Chambless, LE
   Rosamond, WD
   Boland, LL
   Ballantyne, CM
   McGovern, PG
   Sharrett, AR
AF Shahar, E
   Chambless, LE
   Rosamond, WD
   Boland, LL
   Ballantyne, CM
   McGovern, PG
   Sharrett, AR
TI Plasma lipids, lipoproteins, and apolipoproteins and incident ischemic
   stroke: The ARIC study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Minnesota, Minneapolis, MN USA.
   Univ N Carolina, Chapel Hill, NC USA.
   Baylor Coll Med, Houston, TX 77030 USA.
   NIH, Bethesda, MD 20892 USA.
RI Ballantyne, Christie/A-6599-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P63
BP 1363
EP 1363
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200123
ER

PT J
AU Burchfiel, CM
   Skelton, TN
   Andrew, ME
   Garrison, RJ
   Arnett, DK
   Jones, DW
   Taylor, HA
AF Burchfiel, CM
   Skelton, TN
   Andrew, ME
   Garrison, RJ
   Arnett, DK
   Jones, DW
   Taylor, HA
TI Insulin resistance syndrome and echocardiographic left ventricular mass
   in African-Americans
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Jackson, MS USA.
   Univ Mississippi, Med Ctr, Jackson, MS 39216 USA.
   Jackson State Univ, Jackson, MS USA.
   Univ Minnesota, Minneapolis, MN 55455 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P70
BP 1364
EP 1364
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200130
ER

PT J
AU Bazzano, LA
   He, J
   Ogden, LG
   Vupputuri, S
   Loria, C
   Myers, L
   Whelton, PK
AF Bazzano, LA
   He, J
   Ogden, LG
   Vupputuri, S
   Loria, C
   Myers, L
   Whelton, PK
TI Dietary vitamin E intake and risk of coronary heart disease in a
   representative sample of US adults: NHANES I Epidemiologic Follow-up
   Study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA.
   NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P78
BP 1366
EP 1366
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200138
ER

PT J
AU Erlinger, TP
   Guallar, E
   Stolzenberg-Solomon, R
   Miller, ER
   Appel, LJ
AF Erlinger, TP
   Guallar, E
   Stolzenberg-Solomon, R
   Miller, ER
   Appel, LJ
TI Is the relationship between serum beta-carotene and cardiovascular
   disease (CVD) risk confounded by inflammation?
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
   Johns Hopkins Sch Hyg & Publ Hlth, Baltimore, MD USA.
   NCI, Bethesda, MD 20892 USA.
RI Guallar, Eliseo/D-3807-2014
OI Guallar, Eliseo/0000-0002-4471-9565
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P80
BP 1366
EP 1366
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200140
ER

PT J
AU Gross, MD
   Yu, XH
   Hilner, J
   Loria, C
   Steffen-Batey, L
   Jacobs, DR
AF Gross, MD
   Yu, XH
   Hilner, J
   Loria, C
   Steffen-Batey, L
   Jacobs, DR
TI Black-white differences in serum antioxidant concentrations reflect
   differences in food intake: the Coronary Artery Risk Development in
   Young Adults (CARDIA) study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Univ Minnesota, Minneapolis, MN USA.
   Univ Alabama, Birmingham, AL USA.
   NHLBI, Bethesda, MD 20892 USA.
RI Yu, Xinhua/D-5570-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P79
BP 1366
EP 1366
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200139
ER

PT J
AU He, J
   Bazzano, LA
   Ogden, LG
   Loria, CM
   Myers, L
   Whelton, PK
AF He, J
   Bazzano, LA
   Ogden, LG
   Loria, CM
   Myers, L
   Whelton, PK
TI Dietary fiber intake and reduced risk of coronary heart disease in US
   men and women
SO CIRCULATION
LA English
DT Meeting Abstract
C1 Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA.
   NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P81
BP 1366
EP 1366
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200141
ER

PT J
AU Loria, CM
   Roseman, JM
   Hilner, JE
   Cornwell, PE
   Schreiner, PJ
   Siscovick, DS
AF Loria, CM
   Roseman, JM
   Hilner, JE
   Cornwell, PE
   Schreiner, PJ
   Siscovick, DS
TI Predictors of seven-year change in homocysteine concentrations in the
   coronary artery risk development in young adults (CARDIA) study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Bethesda, MD 20892 USA.
   Univ Alabama, Birmingham, AL USA.
   Univ Minnesota, Minneapolis, MN USA.
   Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P87
BP 1367
EP 1367
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200147
ER

PT J
AU O'Donnell, CJ
   Larson, MG
   Kupka, M
   Manning, WJ
   Levy, D
   Clouse, ME
AF O'Donnell, CJ
   Larson, MG
   Kupka, M
   Manning, WJ
   Levy, D
   Clouse, ME
TI Cumulative effects of cholesterol and other risk factors on coronary
   artery calcification in men and women: the Framingham Heart Study
SO CIRCULATION
LA English
DT Meeting Abstract
C1 NHLBI, Framingham Heart Study, Framingham, MA USA.
   Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2001
VL 103
IS 9
MA P92
BP 1368
EP 1368
PG 1
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 412NX
UT WOS:000167562200152
ER

PT J
AU Koonin, EV
AF Koonin, EV
TI Computational genomics
SO CURRENT BIOLOGY
LA English
DT Editorial Material
ID PROTEIN
C1 Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
RP Koonin, EV (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
EM koonin@ncbi.nlm.nih.gov
NR 10
TC 9
Z9 10
U1 0
U2 1
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0960-9822
J9 CURR BIOL
JI Curr. Biol.
PD MAR 6
PY 2001
VL 11
IS 5
BP R155
EP R158
DI 10.1016/S0960-9822(01)00081-1
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 438WD
UT WOS:000169076500004
PM 11267880
ER

PT J
AU Baker, BM
   Turner, RV
   Gagnon, SJ
   Wiley, DC
   Biddison, WE
AF Baker, BM
   Turner, RV
   Gagnon, SJ
   Wiley, DC
   Biddison, WE
TI Identification of a crucial energetic footprint on the al helix of human
   histocompatibility leukocyte antigen (HLA)-A2 that provides functional
   interactions for recognition by tax peptide/HLA-A2-specifrc T cell
   receptors
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE T cell receptor; major histocompatibility complex class I-peptide
   complex; T cell activation; CD8(+) T cell; binding kinetics
ID CLASS-I MHC; ALANINE-SCANNING MUTAGENESIS; POLYMERASE CHAIN-REACTION;
   ALPHA-BETA; CRYSTAL-STRUCTURE; PEPTIDE COMPLEX; LIMITED REGIONS; VIRAL
   PEPTIDE; VIRUS TYPE-1; HTLV-1 TAX
AB Structural studies have shown that class I major histocompatibility complex (MHC)-restricted peptide-specific T cell receptor (TCR)-alpha/betas make multiple contacts with the alpha1 and alpha2 helices of the MHC, but it is unclear which or how many of these interactions contribute to functional binding. We have addressed this question by performing single amino acid mutagenesis of the 15 TCR contact sites on the human histocompatibility leukocyte antigen (HLA)-A2 molecule recognized by the A6 TCR specific for the Tax peptide presented by HLA-A2. The results demonstrate that mutagenesis of only three amino acids (R65, K66, and A69) that are clustered on the alpha1 helix affected T cell recognition of the Tax/HLA-A2 complex. At least one of these three mutants affected T cell recognition by every member of a large panel of Tax/HLA-A2-specific T cell lines. Biacore measurements showed that these three HLA-A2 mutations also altered A6 TCR binding kinetics, reducing binding affinity. These results show that for Tax/HLA-A2-specific TCRs, there is a location on the central portion of the alpha1 helix that provides interactions crucial to their function with the MHC molecule.
C1 NINDS, Mol Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA.
   Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA.
   Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA.
RP Biddison, WE (reprint author), NINDS, Mol Immunol Sect, Neuroimmunol Branch, NIH, Bldg 10,Rm 5B-16, Bethesda, MD 20892 USA.
RI Baker, Brian/B-4584-2009
OI Baker, Brian/0000-0002-0864-0964
NR 50
TC 54
Z9 55
U1 0
U2 1
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD MAR 5
PY 2001
VL 193
IS 5
BP 551
EP 562
DI 10.1084/jem.193.5.551
PG 12
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 411WN
UT WOS:000167522500002
PM 11238586
ER

PT J
AU Strickland, I
   Kisich, K
   Hauk, PJ
   Vottero, A
   Chrousos, GP
   Klemm, DJ
   Leung, DYM
AF Strickland, I
   Kisich, K
   Hauk, PJ
   Vottero, A
   Chrousos, GP
   Klemm, DJ
   Leung, DYM
TI High constitutive glucocorticoid receptor beta in human neutrophils
   enables them to reduce their spontaneous rate of cell death in response
   to corticosteroids
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE neutrophils; glucocorticoid insensitivity; glucocorticoid receptor;
   interleukin 8; inflammation
ID STREPTOLYSIN-O; APOPTOSIS; ISOFORM; EXPRESSION; BINDING; DEXAMETHASONE;
   INFLAMMATION; SPECIFICITY; ASTHMA
AB Neutrophils are markedly less sensitive to glucocorticoids than T cells, making it difficult to control inflammation in neutrophil-mediated diseases. Development of new antiinflammatory strategies for such diseases would be aided by an understanding of mechanisms underlying differential steroid responsiveness. Two protein isoforms of the human glucocorticoid receptor (GR) exist, GR alpha and GR beta, which arise from alternative splicing of the GR pre-mRNA primary transcripts. GR beta does not bind glucocorticoids and is an inhibitor of GR alpha activity. Relative amounts of these two GRs can therefore determine the level of glucocorticoid sensitivity. In this study, human neutrophils and peripheral blood mononuclear cells (PBMCs) were studied to determine the relative amounts of each GR isoform.
   The mean fluorescence intensity (MFI) using immunofluorescence analysis for GR alpha was 475 +/- 62 and 985 +/- 107 for PBMCs and neutrophils, respectively. For GR beta, the MFI was 350 +/- 60 and 1,389 +/- 143 for PBMCs and neutrophils, respectively (P < 0.05). After interleukin (IL)-8 stimulation of neutrophils, there was a statistically significant increase in intensity of GR<beta> staining to 2,497 +/- 140 (P < 0.05). No change in GR<alpha> expression was observed. This inversion of the GR alpha /GR beta ratio in human neutrophils compared with PBMCs was confirmed by quantitative Western analysis. Increased GR beta mRNA expression in neutrophils at baseline, and after IL-8 exposure, was observed using RNA dot blot analysis. Increased levels of GR alpha /GR beta heterodimers were found in neutrophils as compared with PBMCs using coimmunoprecipitation/Western analysis. Transfection of mouse neutrophils, which do not contain GR beta, resulted in a significant reduction in the rate of cell death when treated with dexamethasone.
   We conclude that high constitutive expression of GR beta by human neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Moreover, upregulation of this GR by proinflammatory cytokines such as IL-8 further enhances their survival in the presence of glucocorticoids during inflammation.
C1 Natl Jewish Med Res Ctr, Dept Pediat, Denver, CO 80206 USA.
   Natl Jewish Med Res Ctr, Dept Med, Denver, CO 80206 USA.
   Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA.
   NICHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
RP Leung, DYM (reprint author), Natl Jewish Med Res Ctr, Dept Pediat, 1400 Jackson St, Denver, CO 80206 USA.
FU NCRR NIH HHS [M01 RR000051, MO1 RR00051]; NHLBI NIH HHS [HL34303,
   HL36577, HL37260, P01 HL034303, P01 HL036577, R37 HL037260]; NIAMS NIH
   HHS [AR41256, R01 AR041256]
NR 29
TC 142
Z9 148
U1 2
U2 2
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA
SN 0022-1007
J9 J EXP MED
JI J. Exp. Med.
PD MAR 5
PY 2001
VL 193
IS 5
BP 585
EP 593
DI 10.1084/jem.193.5.585
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 411WN
UT WOS:000167522500005
PM 11238589
ER

PT J
AU Pepper, JP
   Baumann, MH
   Ayestas, M
   Rothman, RB
AF Pepper, JP
   Baumann, MH
   Ayestas, M
   Rothman, RB
TI Inhibition of MAO-A fails to alter cocaine-induced increases in
   extracellular dopamine and norepinephrine in rat nucleus accumbens
SO MOLECULAR BRAIN RESEARCH
LA English
DT Article
DE dopamine; norepinephrine; clorgyline; cocaine; microdialysis; addiction
ID MONOAMINE-OXIDASE; AMPHETAMINE; SEROTONIN; STRIATUM; RELEASE;
   FENFLURAMINE; VOLUNTEERS; METABOLISM; RESPONSES; PIMOZIDE
AB Monoamine oxidase (MAO) inhibitors are being investigated as possible medications for cocaine dependence, but there: are potential problems with this approach. In the present study, we tested the hypothesis that inhibition of catecholamine metabolism with the MAO-A inhibitor, clorgyline, might enhance cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens. Male rats were pretreated with clorgyline (1 mg/kg, s.c.) or its saline vehicle (1 ml/kg, s.c.), and microdialysis probes were inserted into previously implanted guide cannulae. After overnight perfusion of the probes in situ, rats received an acute challenge injection of either cocaine (1 mg/kg, i.v.) or its saline vehicle (1 ml/kg, i.v.). Clorgyline pretreatment alone caused significant elevations in basal levels of dialysate norepinephrine but not dopamine. Cocaine administration elicited significant increases in extracellular dopamine and norepinephrine in all groups of rats, and this effect was not altered by clorgyline pretreatment. The 1 mg/kg dose of clorgyline decreased dopamine metabolites in postmortem brain tissue by more than 80%. Our data are consistent with clinical studies that demonstrate pretreatment with the MAO-B selective inhibitor, selegeline, fails to alter cocaine-induced subjective effects in human drug users. Moreover, these findings suggest that adverse consequences related to altered catecholamine transmission would not occur if patients taking phenelzine, a non-selective MAO inhibitor, relapsed and used cocaine. (C) 2001 Elsevier Science B.V. All rights reserved.
C1 NIDA, Clin Psychopharmacol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
RP Rothman, RB (reprint author), NIDA, Clin Psychopharmacol Sect, Intramural Res Program, NIH, POB 5180,5500 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 27
TC 9
Z9 10
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-328X
J9 MOL BRAIN RES
JI Mol. Brain Res.
PD MAR 5
PY 2001
VL 87
IS 2
BP 184
EP 189
DI 10.1016/S0169-328X(01)00013-4
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 411YG
UT WOS:000167526800005
ER

PT J
AU Culmsee, C
   Bondada, S
   Mattson, MP
AF Culmsee, C
   Bondada, S
   Mattson, MP
TI Hippocampal neurons of mice deficient in DNA-dependent protein kinase
   exhibit increased vulnerability to DNA damage, oxidative stress and
   excitotoxicity
SO MOLECULAR BRAIN RESEARCH
LA English
DT Article
DE Alzheimer's disease; amyloid beta-peptide; DNA repair; epileptic
   seizure; glutamate; topoisomerase inhibitor
ID SEVERE COMBINED IMMUNODEFICIENCY; ISCHEMIC BRAIN INJURY; CELL-CYCLE
   ARREST; V(D)J RECOMBINATION; CATALYTIC SUBUNIT; FOREBRAIN ISCHEMIA;
   NITRIC-OXIDE; APOPTOSIS; DEATH; REPAIR
AB DNA damage has been documented in neurodegenerative conditions ranging from Alzheimer's disease to stroke. DNA-dependent protein kinase (DNA-PK) is involved in V(D)J recombination and DNA double strand break repair, and may play a role in cell death induced by DNA damage. We now report that cultured hippocampal neurons from severe combined immunodeficient (scid) mice which lack DNA-PK activity are hypersensitive to apoptosis induced by exposure to topoisomerase inhibitors, amyloid beta peptide (AP) and glutamate. A similar increased vulnerability of hippocampal CAI and CA3 neurons was observed in adult scid mice after kainate-induced seizures. Our results suggest that DNA-PK activity is important for neuron survival under conditions that may occur in neurological disorders. (C) 2001 Elsevier Science B.V. All rights reserved.
C1 NIA, Gerontol Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA.
   Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.
   Univ Marburg, Inst Pharmakol & Toxikol, D-35037 Marburg, Germany.
   Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY 40536 USA.
   Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA.
RP Mattson, MP (reprint author), NIA, Gerontol Res Ctr, Neurosci Lab, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
RI Mattson, Mark/F-6038-2012
NR 47
TC 36
Z9 36
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-328X
J9 MOL BRAIN RES
JI Mol. Brain Res.
PD MAR 5
PY 2001
VL 87
IS 2
BP 257
EP 262
DI 10.1016/S0169-328X(01)00008-0
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 411YG
UT WOS:000167526800014
ER

PT J
AU Aroniadou-Anderjaska, V
   Post, RM
   Rogawski, MA
   Li, H
AF Aroniadou-Anderjaska, V
   Post, RM
   Rogawski, MA
   Li, H
TI Input-specific LTP and depotentiation in the basolateral amygdala
SO NEUROREPORT
LA English
DT Article
DE amygdala; bidirectional plasticity; depotentiation; long-term
   depression; long-term potentiation
ID LONG-TERM POTENTIATION; TRANSCRANIAL MAGNETIC STIMULATION; BIDIRECTIONAL
   SYNAPTIC PLASTICITY; RAT; PROJECTIONS; CALCIUM; TRANSMISSION;
   METABOLISM; DEPRESSION; NEURONS
AB The amygdala plays a central role in emotional memory. The cellular mechanisms by which the amygdala participates in emotional learning are believed to be changes in efficacy of synaptic transmission, similar to long-term potentiation (LTP) and long-term depression (LTD). Although different forms of FTP have been shown in the amygdala, many of their features are still unknown. Here, we use both field potential and intracellular recordings in rat amygdala slices, and show that LTP in the basolateral nucleus, induced by high-frequency stimulation (HFS) of the external capsule is input-specific, can be reversed by low-frequency stimulation (LFS), and can be reinstated by HFS. These synapse-specific, reversible changes in synaptic strength in the basolateral nucleus of the amygdala may be important to amygdala's role in emotional memory. NeuroReport 12:635-640 (C) 2001 Lippincott Williams & Wilkins.
C1 Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
   NIMH, Biol Psychiat Branch, NIH, Bethesda, MD 20892 USA.
   NINDS, Epilepsy Res Branch, NIH, Bethesda, MD 20892 USA.
RP Aroniadou-Anderjaska, V (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
RI Rogawski, Michael/B-6353-2009; yu, yan/C-2322-2012
OI Rogawski, Michael/0000-0002-3296-8193; 
NR 25
TC 27
Z9 27
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0959-4965
J9 NEUROREPORT
JI Neuroreport
PD MAR 5
PY 2001
VL 12
IS 3
BP 635
EP 640
DI 10.1097/00001756-200103050-00041
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 403XT
UT WOS:000167069000041
PM 11234779
ER

PT J
AU Groll, AH
AF Groll, AH
TI Drug therapy in paediatric patients
SO LANCET
LA English
DT Letter
C1 NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA.
RP Groll, AH (reprint author), NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA.
NR 5
TC 3
Z9 3
U1 0
U2 0
PU LANCET LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0140-6736
J9 LANCET
JI Lancet
PD MAR 3
PY 2001
VL 357
IS 9257
BP 719
EP 719
DI 10.1016/S0140-6736(05)71476-8
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 407QN
UT WOS:000167282400050
PM 11247583
ER

PT J
AU Durell, SR
   Guy, HR
AF Durell, SR
   Guy, HR
TI A putative prokaryote voltage-gated Ca2+ channel with only one 6TM motif
   per subunit
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
ID SHAKER K+ CHANNEL; MOLECULAR-CLONING; ION-CHANNEL; RECEPTOR;
   SELECTIVITY; DOMAIN; PORE; PKD2
AB Until now, voltage-gated Ca2+ channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca2+ channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in its pore-forming subunit. This is supported by the comparison of consensus sequences, which, along with the patterns of residue conservation, indicates a similar structure in the membrane to voltage-gated K+ channels. From this we hypothesize that Ca2+ channels originally evolved in bacteria, and that the specific eubacteria protein highlighted here is an ideal candidate for structure determination efforts.
C1 NCI, NIH, Lab Expt & Computat Biol, Mol Struct Sect, Bethesda, MD 20892 USA.
RP Guy, HR (reprint author), NCI, NIH, Lab Expt & Computat Biol, Bldg 12B,Room B116,12 South Dr, Bethesda, MD 20892 USA.
NR 27
TC 40
Z9 45
U1 0
U2 0
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 2
PY 2001
VL 281
IS 3
BP 741
EP 746
DI 10.1006/bbrc.2001.4408
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 409XJ
UT WOS:000167410700021
PM 11237720
ER

PT J
AU Turchan, J
   Anderson, C
   Hauser, KF
   Sun, QM
   Zhang, JY
   Liu, Y
   Wise, PM
   Kruman, I
   Maragos, W
   Mattson, MP
   Booze, R
   Nath, A
AF Turchan, Jadwiga
   Anderson, Caroline
   Hauser, Kurt F.
   Sun, Qinmiao
   Zhang, Jiayou
   Liu, Ying
   Wise, Phyllis M.
   Kruman, Inna
   Maragos, William
   Mattson, Mark P.
   Booze, Rosemarie
   Nath, Avindra
TI Estrogen protects against the synergistic toxicity by HIV proteins,
   methamphetamine and cocaine
SO BMC NEUROSCIENCE
LA English
DT Article
AB Background: Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the brain and HIV infection frequently leads to a dementing illness. To determine how these drugs interact with HIV to cause CNS damage, we used an in vitro human neuronal culture characterized for the presence of dopaminergic receptors, transporters and estrogen receptors. We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat.
   Results: Acute exposure to these substances resulted in synergistic neurotoxic responses as measured by changes in mitochondrial membrane potential and neuronal cell death. Neurotoxicity occurred in a sub-population of neurons. Importantly, the presence of 17beta-estradiol prevented these synergistic neurotoxicities and the neuroprotective effects were partly mediated by estrogen receptors.
   Conclusion: Our observations suggest that methamphetamine and cocaine may affect the course of HIV dementia, and additionally suggest that estrogens modify the HIV-drug interactions.
C1 [Turchan, Jadwiga; Anderson, Caroline; Sun, Qinmiao; Maragos, William; Nath, Avindra] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA.
   [Turchan, Jadwiga; Anderson, Caroline; Sun, Qinmiao; Zhang, Jiayou; Nath, Avindra] Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY 40536 USA.
   [Hauser, Kurt F.; Maragos, William; Booze, Rosemarie] Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY 40536 USA.
   [Liu, Ying; Wise, Phyllis M.] Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA.
   [Mattson, Mark P.] NIA, Neurosci Lab, Baltimore, MD 21224 USA.
RP Nath, A (reprint author), Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA.
EM jturc2@pop.uky.edu; cfmart@pop.uky.edu; khauser@pop.uky.edu;
   qsun2@pop.uky.edu; jzhan1@pop.uky.edu; yliu6@pop.uky.edu;
   pmwise1@pop.uky.edu; krumanln@grc.nia.nih.gov; maragos@pop.uky.edu;
   mattsonm@grc.nia.nih.gov; booz@pop.uky.edu; anath@pop.uky.edu
RI Mattson, Mark/F-6038-2012
FU NIH
FX This manuscript was supported by NIH grants awarded to AN, KH, PW, RB,
   and WM. We also thank Melinda Wilson for assistance.
NR 34
TC 80
Z9 83
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD MAR 2
PY 2001
VL 2
AR 3
DI 10.1186/1471-2202-2-3
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA V11JJ
UT WOS:000207527600001
PM 11252157
ER

PT J
AU Gerasimov, MR
   Schiffer, WK
   Gardner, EL
   Marsteller, DA
   Lennon, IC
   Taylor, SJC
   Brodie, JD
   Ashby, CR
   Dewey, SL
AF Gerasimov, MR
   Schiffer, WK
   Gardner, EL
   Marsteller, DA
   Lennon, IC
   Taylor, SJC
   Brodie, JD
   Ashby, CR
   Dewey, SL
TI GABAergic blockade of cocaine-associated cue-induced increases in
   nucleus accumbens dopamine
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE cocaine; conditioning; contextual cue; microdialysis; in vivo; GABA
   (gamma-aminobutyric acid); vigabatrin
ID CONDITIONED PLACE PREFERENCE; SELF-ADMINISTERED COCAINE; EXTRACELLULAR
   DOPAMINE; SEEKING BEHAVIOR; ANIMAL-MODEL; REWARD; HEROIN; RATS;
   REINSTATEMENT; AMYGDALA
AB Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously paired with cocaine administration. In animals exposed to a cocaine-paired environment nucleus accumbens dopamine increased by 25%. When administered 2.5 h prior to presentation of the environmental trigger, racemic vigabatrin tan irreversible inhibitor of gamma -aminobutyric acid (GABA)-transaminase) abolished this cue-induced increase. Conversely, R-(-)-vigabatrin, the inactive enantiomer, had no effect. Combined with our earlier findings, these studies support the potential therapeutic benefit of this enzyme-based GABAergic strategy to modulate brain dopamine and the subsequent treatment of drug addiction. (C) 2001 Elsevier Science B.V. All rights: reserved.
C1 Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA.
   NIDA, Intramural Res Program, Baltimore, MD 21224 USA.
   Chirotech Technol Ltd, Cambridge CB4 0WG, England.
   NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA.
   St Johns Univ, Dept Pharmaceut Hlth Sci, Jamaica, NY 11439 USA.
RP Gerasimov, MR (reprint author), Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA.
FU NIMH NIH HHS [MH49165]; PHS HHS [R2955155]
NR 24
TC 44
Z9 46
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAR 2
PY 2001
VL 414
IS 2-3
BP 205
EP 209
DI 10.1016/S0014-2999(01)00800-7
PG 5
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 411EM
UT WOS:000167485200010
PM 11239920
ER

PT J
AU Wu, VW
   Mo, Q
   Yabe, T
   Schwartz, JP
   Robinson, SE
AF Wu, VW
   Mo, Q
   Yabe, T
   Schwartz, JP
   Robinson, SE
TI Perinatal opioids reduce striatal nerve growth factor content in rat
   striatum
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE buprenorphine; methadone; NGF (nerve growth factor); perinatal;
   striatum; rat
ID CHOLINERGIC NEURONS; PRENATAL EXPOSURE; NEONATAL RATS; METHADONE
   EXPOSURE; FACTOR EXPRESSION; BRAIN; ASTROCYTES; CULTURES; INTERNEURONS;
   LOCALIZATION
AB Both human and animal models indicate that perinatal methadone exposure produces a variety of short- and long-term neurobehavioral consequences, including disruption of normal development of striatal cholinergic neurons. Despite this, methadone maintenance is a standard method of managing pregnant heroin addicts, and the opioid receptor partial agonist buprenorphine is under evaluation for the same use. We now report that perinatal administration of either methadone or buprenorphine reduces the content of the neurotrophic factor nerve growth factor (NGF) in rat striatum, which may explain the behavioral deficits observed. Furthermore, although NGF content is reduced, there are no corresponding reductions in striatal NGF mRNA. (C) 2001 Published by Elsevier Science B.V.
C1 Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA.
   NINDS, Neurotroph Factors Sect, NIH, Bethesda, MD 20892 USA.
RP Robinson, SE (reprint author), Med Coll Virginia, Dept Pharmacol & Toxicol, Campus Virginia Commonwealth Univ, Richmond, VA 23298 USA.
FU NIDA NIH HHS [DA05274, R01 DA09399]
NR 25
TC 23
Z9 24
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAR 2
PY 2001
VL 414
IS 2-3
BP 211
EP 214
DI 10.1016/S0014-2999(01)00807-X
PG 4
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 411EM
UT WOS:000167485200011
PM 11239921
ER

PT J
AU Saha, T
   Usdin, K
AF Saha, T
   Usdin, K
TI Tetraplex formation by the progressive myoclonus epilepsy type-1 repeat:
   implications for instability in the repeat expansion diseases
SO FEBS LETTERS
LA English
DT Article
DE repeat expansion; DNA structure; instability
ID CYSTATIN-B GENE; G-C REPEATS; FRIEDREICHS-ATAXIA; TRIPLET REPEATS; DNA
   QUADRUPLEX; TELOMERIC SEQUENCES; HAIRPIN STRUCTURES; FORM HAIRPINS;
   IN-VITRO; STRANDS
AB The repeat expansion diseases are a group of genetic disorders resulting from an increase in size or expansion of a specific array of tandem repeats. It has been suggested that DNA secondary structures are responsible for this expansion, If this is so, we would expect that all unstable repeats should form such structures. We show here that the unstable repeat that causes progressive myoclonus epilepsy type-1 (EPM1), like the repeats associated,vith other diseases in this category, forms a variety of secondary structures, However, EPM1 is unique in that tetraplexes are the only structures likely to form in long unpaired repeat tracts under physiological conditions. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.
C1 NIDDKD, Sect Genom Struct & Funct, Mol & Cellular Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Usdin, K (reprint author), NIDDKD, Sect Genom Struct & Funct, Mol & Cellular Biol Lab, NIH, Bldg 8,Room 202,8 Ctr DR MSC 0830, Bethesda, MD 20892 USA.
NR 44
TC 28
Z9 29
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-5793
J9 FEBS LETT
JI FEBS Lett.
PD MAR 2
PY 2001
VL 491
IS 3
BP 184
EP 187
DI 10.1016/S0014-5793(01)02190-1
PG 4
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 408XT
UT WOS:000167352800004
PM 11240124
ER

PT J
AU Elnitski, L
   Li, J
   Noguchi, CT
   Miller, W
   Hardison, R
AF Elnitski, L
   Li, J
   Noguchi, CT
   Miller, W
   Hardison, R
TI A negative cis-element regulates the level of enhancement by
   hypersensitive site 2 of the beta-globin locus control region
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID DOMINANT CONTROL REGION; BZIP TRANSCRIPTION FACTOR; PROTEIN DNA
   INTERACTIONS; OPEN CHROMATIN STRUCTURE; TRANSGENIC MICE;
   GENE-EXPRESSION; ERYTHROID-CELLS; DEVELOPMENTAL REGULATION;
   ERYTHROLEUKEMIA-CELLS; ACTIVATION REGION
AB The core of DNase hypersensitive site (HS) 2 from the beta -globin locus control region is a potent enhancer of globin gene expression. Although it has been considered to contain only positive cis-regulatory sequences, our study of the enhancement conferred by segments of HS2 in erythroid cells reveals a novel negative element. Individual cis-regulatory elements from HS2 such as E boxes or Maf-response elements produced as great or greater enhancement than the intact core in mouse erythroleukemia (MEL) cells, indicating the presence of negative elements within HS2. A deletion series through HS2 revealed negative elements at the 5' and 3' ends of the core. Analysis of constructs with and without the 5' negative element showed that the effect is exerted on the promoters of globin genes expressed at embryonic, fetal, or adult stages. The negative effect was observed in bipotential human cells (K562 and human erythroleukemia (HEL) cells), proerythroblastic mouse (MEL) cells, and normal adult human erythroid cells. The novel negative element also functions after stable integration into MEL chromosomes. Smaller deletions at the 5' end of the HS2 core map the negative element within a 20-base pair region containing two conserved sequences.
C1 Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 206, University Pk, PA 16802 USA.
   Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
   Penn State Univ, Ctr Gene Regulat, University Pk, PA 16802 USA.
   NIDDK, Biol Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Hardison, R (reprint author), Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 206, University Pk, PA 16802 USA.
RI Hardison, Ross/G-1142-2010
OI Hardison, Ross/0000-0003-4084-7516
FU NIDDK NIH HHS [R01DK27635]; NLM NIH HHS [R01LM05110, R01LM05773]
NR 74
TC 13
Z9 16
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 2
PY 2001
VL 276
IS 9
BP 6289
EP 6298
DI 10.1074/jbc.M009624200
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 407FF
UT WOS:000167261000032
PM 11092897
ER

PT J
AU Khaled, AR
   Reynolds, DA
   Young, HA
   Thompson, CB
   Muegge, K
   Durum, SK
AF Khaled, AR
   Reynolds, DA
   Young, HA
   Thompson, CB
   Muegge, K
   Durum, SK
TI Interleukin-3 withdrawal induces an early increase in mitochondrial
   membrane potential unrelated to the Bcl-2 fammily - Roles of
   intracellular pH, ADP transport, and F0F1-ATPase
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PERMEABILITY TRANSITION PORE; CYTOCHROME-C; ATP SYNTHASE; CELL-DEATH;
   HEMATOPOIETIC-CELLS; INHIBITOR PROTEIN; CULTURED-CELLS; APOPTOSIS;
   RELEASE; JC-1
AB Cytokines such as interleukin-3 (IL-3) promote the survival of hematopoietic cells through mechanisms that are not well characterized. Withdrawal of IL-3 from an IL-3-dependent pro-B cell line induced early stress-related events that preceded cell death by more than 40 h. Intracellular pH rose above pH 7.8, peaking 2-3 h post-IL-3 withdrawal, and induced a transient increase in mitochondrial membrane potential (Delta psi (m)) detected using several different dyes. Similar events were observed following IL-7 withdrawal from a different dependent cell line. Bcl-2, Bax, and caspases were unrelated to these early events. Intracellular alkaline pH inhibited the mitochondrial import of ADP, which would limit ATP synthesis. Total cellular ATP sharply declined during this early period, presumably as a consequence of suppressed ADP import. This was followed by an increase in reduced pyridine nucleotides. The transient increase in Delta psi (m) was blocked by oligomycin, an inhibitor of F0F1. ATPase that may have undergone reversal caused by the abnormal ADP-ATP balance within mitochondria. These findings suggest a novel sequence of early events following trophic factor withdrawal in which alkaline pH inhibits ADP import into mitochondria, reversing the F0F1. ATPase, which in turn consumes ATP and pumps out protons, raising Delta psi (m).
C1 NCI, Sect Cytokines & Immun, Mol Immunoregulat Lab, Div Basic Sci,NIH, Frederick, MD 21702 USA.
   NCI, Expt Immunol Lab, Div Basic Sci, NIH, Frederick, MD 21702 USA.
   Sci Applicat Int Corp, Frederick, MD 21702 USA.
   Univ Penn, Philadelphia, PA 19104 USA.
RP Durum, SK (reprint author), NCI, Sect Cytokines & Immun, Mol Immunoregulat Lab, Div Basic Sci,NIH, Bldg 560,Rm 31-71, Frederick, MD 21702 USA.
NR 45
TC 69
Z9 70
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 2
PY 2001
VL 276
IS 9
BP 6453
EP 6462
DI 10.1074/jbc.M006391200
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 407FF
UT WOS:000167261000052
PM 11102440
ER

PT J
AU Redmond, TM
   Gentleman, S
   Duncan, T
   Yu, S
   Wiggert, B
   Gantt, E
   Cunningham, FX
AF Redmond, TM
   Gentleman, S
   Duncan, T
   Yu, S
   Wiggert, B
   Gantt, E
   Cunningham, FX
TI Identification, expression, and substrate specificity of a mammalian
   beta-carotene 15,15 '-dioxygenase
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PSEUDOMONAS-PAUCIMOBILIS TMY1009; RETINOIC ACID; PIGMENT-EPITHELIUM;
   FUNCTIONAL-ANALYSIS; MICROSOMAL PROTEIN; ENZYMATIC CLEAVAGE; LYCOPENE
   CYCLASE; ENZYMES; CLONING; RPE65
AB We have identified from mouse the first mammalian beta -carotene 15,15'-dioxygenase (beta -CD), a crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors. beta -CD is related to the retinal pigment epithelium expressed protein RPE65 and belongs to a diverse family that includes the plant 9-cis-epoxycarotenoid dioxygenase and bacterial lignostilbene dioxygenases. beta -CD expression in Escherichia coli cells engineered to produce beta -carotene led to the accumulation of all-trans-retinal at the expense of beta -carotene, confirming that beta -CD catalyzed the central cleavage of this vitamin A precursor. Purified recombinant beta -CD protein cleaves beta -carotene in vitro with a V-max of 36 pmol of retinal/mg of enzyme/ min and a K-m of 6 muM. Non-provitamin A carotenoids were also cleaved, although with much lower activity. By Northern analysis, a 2.4-kilobase (kb) message was observed in liver, kidney, small intestine, and testis, tissues important in retinoid/carotenoid metabolism. This message encoded a 63-kDa cytosolic protein expressed in these tissues. A shorter transcript of 1.8 kb was found in testis and skin. Developmentally, the 2,4-kb mRNA was abundant at embryonic day 7, with lower expression at embryonic days 11, 13, and 15, suggesting a critical role for this enzyme in gastrulation. Identification of beta -CD in an accessible model organism will create new opportunities to study vitamin A metabolism.
C1 NEI, LRCMB, NIH, Bethesda, MD 20892 USA.
   Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA.
RP Redmond, TM (reprint author), NEI, LRCMB, NIH, Bldg 6,Rm 339,6 Ctr Dr,MSC 2740, Bethesda, MD 20892 USA.
OI Redmond, T. Michael/0000-0002-1813-5291
NR 39
TC 199
Z9 205
U1 4
U2 12
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 2
PY 2001
VL 276
IS 9
BP 6560
EP 6565
DI 10.1074/jbc.M009030200
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 407FF
UT WOS:000167261000066
PM 11092891
ER

PT J
AU Humphrey, GW
   Wang, YH
   Russanova, VR
   Hirai, T
   Qin, J
   Nakatani, Y
   Howard, BH
AF Humphrey, GW
   Wang, YH
   Russanova, VR
   Hirai, T
   Qin, J
   Nakatani, Y
   Howard, BH
TI Stable histone deacetylase complexes distinguished by the presence of
   SANT domain proteins CoREST/kiaa0071 and Mta-L1
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID TRANSCRIPTIONAL REPRESSION; NUCLEAR MATRIX; POLYAMINE OXIDASE;
   BINDING-PROTEINS; DNA METHYLATION; N-COR; YEAST; GENE; RPD3; SUPERFAMILY
AB Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84% identity) that catalyze release of acetyl groups from modified N-terminal lysines of core histones, Histone deacetylation is correlated with both transient and persistent states of transcriptional inactivity (i.e. silencing) in many eukaryotes, In this study, we analyzed complexes containing HDAC1 and HDAC2 to identify the proteins most stably associated with these deacetylases. Complex cI (9.5 S) contained transcriptional corepressor CoREST/ kiaa0071 and a protein homologous to FAD-dependent oxidoreductases, kiaa0601, Complex cII (15 S) contained greater than or equal to 15 proteins, including CHD3/4 (Mi-2), Mta-L1, RbAp48/ 46, and MBD3, characteristic of vertebrate nucleosome-remodeling complexes. Under native conditions, cI and cII may contain HDAC1, HDAC2 or both; these can be dissociated to cI and cII core complexes containing only HDAC1 or HDAC2, The (m)CpG-binding protein MBD2 was associated only with the HDAC1 cII core complex, A model is proposed in which HDAC1 core complexes can be targeted to methylated DNA via MBD2 with recruitment of HDAC2 occurring through formation of HDAC1/2 cII dimers, We note that the cI component CoREST/kiaa0071 and the cII component Mta-L1 share a region of homology that includes a SANT domain; this domain may play a role in complex assembly.
C1 NICHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA.
   Dana Farber Canc Inst, Boston, MA 02115 USA.
   Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA.
RP Howard, BH (reprint author), NICHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA.
NR 52
TC 212
Z9 230
U1 0
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 2
PY 2001
VL 276
IS 9
BP 6817
EP 6824
DI 10.1074/jbc.M007372200
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 407FF
UT WOS:000167261000095
PM 11102443
ER

PT J
AU Cornilescu, CC
   Bouamr, F
   Yao, X
   Carter, C
   Tjandra, N
AF Cornilescu, CC
   Bouamr, F
   Yao, X
   Carter, C
   Tjandra, N
TI Structural analysis of the N-terminal domain of the human T-cell
   leukemia virus capsid protein
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Article
DE HTLV-I; capsid protein; retrovirus; NMR spectroscopy; three-dimensional
   structure; CyP A
ID ROUS-SARCOMA VIRUS; ORIENTED MACROMOLECULES; DIPOLAR COUPLINGS;
   STRUCTURE REFINEMENT; CYCLOPHILIN-A; IN-VITRO; TYPE-1; NMR; SPECTRA;
   MORPHOGENESIS
AB The N-terminal domain of the retroviral capsid (CA) protein is one of the least conserved regions encoded in the genome. Surprisingly, the three-dimensional structures of the CA from different genera exhibit alpha -helical structural features that are highly conserved. The N-terminal residues of the human immunodeficiency virus type 1 (HIV-1) and Rous sarcoma virus (RSV) capsid proteins form a beta -hairpin. To determine if this feature is conserved in the retroviral family, we cloned, expressed, purified, and solved the structure of a N-terminal 134 amino acid fragment (CA(134)) from the human T-cell leukemia virus type 1 (HTLV-I) using high resolution nuclear magnetic resonance (NMR) spectroscopy. The CA(134) fragment contains an N-terminal beta -hairpin and a central coiled-coil-like structure composed of six alpha -helices. The N-terminal Pro1 residue contacts Asp54 in the helical cluster through a salt bridge. Thus, the beta -hairpin is conserved and the helical cluster is structurally similar to other retroviral CA domains. However, although the same Asp residue defines the orientation of the hairpin in both the HTLV-1 and HIV-1 CA proteins, the HTLV-I hairpin is oriented away, rather than towards, the helical core. Significant differences were also detected in the spatial orientation and helical content of the long centrally located loop connecting the helices in the core. It has been proposed that the salt bridge allows the formation of a CA-CA interface that is important for the assembly of the conical cores that are characteristic of HIV-1. As HTLV-I forms spherical cores, the salt-bridge feature is apparently not conserved for this function although its role in determining the orientation of the beta -hairpin may be critical, along with the central loop. Comparison of three-dimensional structures is expected to elucidate the relationships between the retroviral capsid protein structure and its function. (C) 2001 Academic Press.
C1 NHLBI, Biophys Chem Lab, NIH, Bethesda, MD 20892 USA.
   SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA.
   Univ Maryland, Chem Phys Program, College Pk, MD 20742 USA.
RP Carter, C (reprint author), NHLBI, Biophys Chem Lab, NIH, Bldg 3, Bethesda, MD 20892 USA.
RI Cornilescu, Claudia/H-1959-2012; Cornilescu, Claudia/K-1981-2015
OI Cornilescu, Claudia/0000-0002-2401-7806
FU NIGMS NIH HHS [GM 48294]
NR 56
TC 45
Z9 46
U1 0
U2 1
PU ACADEMIC PRESS LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2836
J9 J MOL BIOL
JI J. Mol. Biol.
PD MAR 2
PY 2001
VL 306
IS 4
BP 783
EP 797
DI 10.1006/jmbi.2000.4395
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 409VP
UT WOS:000167406600013
PM 11243788
ER

PT J
AU Hobson, JP
   Rosenfeldt, HM
   Barak, LS
   Olivera, A
   Poulton, S
   Caron, MG
   Milstien, S
   Spiegel, S
AF Hobson, JP
   Rosenfeldt, HM
   Barak, LS
   Olivera, A
   Poulton, S
   Caron, MG
   Milstien, S
   Spiegel, S
TI Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell
   motility
SO SCIENCE
LA English
DT Article
ID PROTEIN-COUPLED RECEPTORS; SPHINGOSINE 1-PHOSPHATE; BETA-ARRESTIN;
   KINASE; PROLIFERATION; ENDOCYTOSIS; SURVIVAL
AB EDG-1 is a heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR) for sphingosine-1-phosphate (SPP). Cell migration toward platelet-derived growth factor (PDGF). which stimulates sphingosine kinase and increases intracellular SPP, was dependent on expression of EDG-1. Deletion of edg-1 or inhibition of sphingosine kinase suppressed chemotaxis toward PDGF and also activation of the small guanosine triphosphatase Rac, which is essential for protrusion of lamellipodia and forward movement. Moreover, PDGF activated EDG-1, as measured by translocation of beta -arrestin and phosphorylation of EDG-1. Our results reveal a role for receptor cross-communication in which activation of a GPCR by a receptor tyrosine kinase is critical for cell motility.
C1 Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA.
   Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA.
   NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA.
RP Spiegel, S (reprint author), Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA.
FU NCI NIH HHS [CA61774]; NHLBI NIH HHS [HL-61365]; NIGMS NIH HHS
   [GM43880]; NINDS NIH HHS [NS19576]
NR 19
TC 328
Z9 339
U1 0
U2 7
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 2
PY 2001
VL 291
IS 5509
BP 1800
EP 1803
DI 10.1126/science.1057559
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 408HK
UT WOS:000167320600063
PM 11230698
ER

PT J
AU Shore, D
   Goldschmidts, W
   Wynne, D
   Hyman, SE
AF Shore, D
   Goldschmidts, W
   Wynne, D
   Hyman, SE
TI NIMH perspective - Meeting national needs for psychiatrist-researchers
SO ACADEMIC PSYCHIATRY
LA English
DT Article
C1 NIMH, Bethesda, MD 20892 USA.
RP Shore, D (reprint author), Room 8235,MSC 9669,6001 Execut Blvd, Bethesda, MD 20892 USA.
NR 1
TC 2
Z9 2
U1 0
U2 0
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST, N W, STE 1101, WASHINGTON, DC 20005 USA
SN 1042-9670
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD SPR
PY 2001
VL 25
IS 1
BP 9
EP 11
DI 10.1176/appi.ap.25.1.9
PG 3
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA 411KX
UT WOS:000167500200004
ER

PT J
AU Jaskolski, M
   Kozak, M
   Lubkowski, J
   Palm, G
   Wlodawer, A
AF Jaskolski, M
   Kozak, M
   Lubkowski, J
   Palm, G
   Wlodawer, A
TI Structures of two highly homologous bacterial L-asparaginases: a case of
   enantiomorphic space groups
SO ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
LA English
DT Article
ID ESCHERICHIA-COLI ASPARAGINASE; 7A GLUTAMINASE-ASPARAGINASE;
   SITE-SPECIFIC MUTAGENESIS; CRYSTAL-STRUCTURE; GLYOXALASE-I; RESIDUES;
   COMPLEX; ENZYME; MUTANT; CONFORMATION
AB Quasi-enantiomorphic crystals of the Y25F mutant of Escherichia coli L-asparaginase and of the native Erwinia chrysanthemi L-asparaginase were obtained in the hexagonal space groups P6(5)22 and P6(1)22, respectively. The structures of these highly homologous enzymes were solved by molecular replacement and were refined with data extending to 2.2-2.5 Angstrom. These structures were compared with each other, as well as with other L-asparaginase structures previously observed with different crystal packing. It is concluded that the observed phenomenon, which is rare, was most likely to have arisen by chance.
C1 Adam Mickiewicz Univ, Fac Chem, Dept Crystallog, Poznan, Poland.
   Polish Acad Sci, Inst Bioorgan Chem, Ctr Biocrystallog Res, Poznan, Poland.
   Adam Mickiewicz Univ, Fac Phys, Dept Macromol Phys, Poznan, Poland.
   NCI, Macromol Crystallog Lab, Program Struct Biol, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
RP Wlodawer, A (reprint author), Adam Mickiewicz Univ, Fac Chem, Dept Crystallog, Grunwaldzka 6, Poznan, Poland.
RI Kozak, Maciej/A-6588-2008
NR 41
TC 17
Z9 20
U1 0
U2 0
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0907-4449
J9 ACTA CRYSTALLOGR D
JI Acta Crystallogr. Sect. D-Biol. Crystallogr.
PD MAR
PY 2001
VL 57
BP 369
EP 377
DI 10.1107/S0907444900020175
PN 3
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Biophysics; Crystallography
SC Biochemistry & Molecular Biology; Biophysics; Crystallography
GA 406TP
UT WOS:000167231500003
PM 11223513
ER

PT J
AU Greberman, SB
   Jasinski, D
AF Greberman, SB
   Jasinski, D
TI Comparison of drug treatment histories of single and multiple drug
   abusers in detox
SO ADDICTIVE BEHAVIORS
LA English
DT Article
DE behavior; addictive/therapy; human; adult; chi-square distribution
ID ALCOHOL-PROBLEMS; SEX-DIFFERENCES; ADDICT CAREERS; CLIENTS
AB This study was undertaken to determine differences in previous treatment patterns in individuals currently using different numbers of substances. Medical records of 1198 inpatient detoxification (detox) admissions were analyzed. Numbers of past admissions to completed deter, methadone, or other types of drug abuse treatment were totaled and ranked to determine most frequent type. Within gender, treatment histories of single and multiple drug abusers usually do not differ. The one exception is male multiple drug abusers ages 26-30, who show increased admissions. Possible explanations are that men do not seek treatment before developing medical complications of addiction or until external factors influence admission. There were differences in treatment histories between genders in multiple drug abusers only. Before age 30, women reported increased treatment of certain types. Possible explanations are that treatment priority is given to women who are, or may be, pregnant. Also, younger men may not enter or complete treatment. Previous treatment history may influence many behaviors. The results of this study delineate several valuable indicators for assessing past history. (C) 2001 Elsevier Science Ltd. All rights reserved.
C1 NIDA, Div Intramural Res, NIH, Baltimore, MD 21224 USA.
   Johns Hopkins Bayview Med Ctr, Baltimore, MD USA.
RP Greberman, SB (reprint author), NIDA, Div Intramural Res, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 9
TC 3
Z9 4
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4603
J9 ADDICT BEHAV
JI Addict. Behav.
PD MAR-APR
PY 2001
VL 26
IS 2
BP 285
EP 288
DI 10.1016/S0306-4603(00)00095-2
PG 4
WC Psychology, Clinical; Substance Abuse
SC Psychology; Substance Abuse
GA 413VF
UT WOS:000167631700011
PM 11316384
ER

PT J
AU Radzius, A
   Moolchan, ET
   Henningfield, JE
   Heishman, SJ
   Gallo, JJ
AF Radzius, A
   Moolchan, ET
   Henningfield, JE
   Heishman, SJ
   Gallo, JJ
TI A factor analysis of the Fagerstrom Tolerance Questionnaire
SO ADDICTIVE BEHAVIORS
LA English
DT Article
DE FTQ; factor analysis; nicotine dependence
ID TETRACHORIC CORRELATION-COEFFICIENT; NICOTINE DEPENDENCE
AB A factor analysis of 1309 Fagerstrom Tolerance Questionnaires (FTQ) was performed with LISCOMP software, which utilizes tetrachoric correlations to account for the dichotomous responses of the FTQ. Three factors with eigenvalues greater than 1.0 were obtained, accounting for 56.6% of the variance. Factor 1 was loaded by questions "How soon on waking do you smoke your first cigarette?," "Do you find it difficult to refrain from smoking in places it is forbidden?," "How many cigarettes a day do you smoke?," and "Do you smoke if you are so ill that you are in bed most of the day?" Factor 2 was loaded by questions "Which cigarette would you hate to give up?" and "Do you smoke more during the morning than during the rest of the day?" Factor 3 was loaded exclusively by question "What brand do you smoke?" The question "Do you inhale always, sometimes, or never?" loaded exclusively on a fourth factor, however its eigenvalue did not reach significance. Support is provided for the modification of the eight-item FTQ to the six-item Fagerstrom Test for Nicotine Dependence (FTND). Based on the wording of the questions that loaded on each factor, we propose that Factor 2 assesses the degree of urgency to initiate smoking after overnight abstinence and that Factor 1 reflects the persistence of smoking during waking hours. (C) 2001 Elsevier Science Ltd. All rights reserved.
C1 NIDA, NIH, IRP,Clin Pharmacol & Therapeut Res Branch, Div Intramural Res, Baltimore, MD 21224 USA.
   Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   Pinney Associates, Bethesda, MD USA.
   Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mental Hyg, Baltimore, MD USA.
RP Radzius, A (reprint author), NIDA, NIH, IRP,Clin Pharmacol & Therapeut Res Branch, Div Intramural Res, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 17
TC 25
Z9 26
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4603
J9 ADDICT BEHAV
JI Addict. Behav.
PD MAR-APR
PY 2001
VL 26
IS 2
BP 303
EP 310
DI 10.1016/S0306-4603(00)00114-3
PG 8
WC Psychology, Clinical; Substance Abuse
SC Psychology; Substance Abuse
GA 413VF
UT WOS:000167631700014
PM 11316387
ER

PT J
AU Yang, CF
   Dash, B
   Hanna, SL
   Frances, HS
   Nzilambi, N
   Colebunders, RC
   St Louis, M
   Quinn, TC
   Folks, TM
   Lal, RB
AF Yang, CF
   Dash, B
   Hanna, SL
   Frances, HS
   Nzilambi, N
   Colebunders, RC
   St Louis, M
   Quinn, TC
   Folks, TM
   Lal, RB
TI Predominance of HIV type 1 subtype G among commercial sex workers from
   Kinshasa, Democratic Republic of Congo
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; GROUP-O; DIVERSE HUMAN; IDENTIFICATION;
   SEQUENCES; INFECTION; DISTINCT
AB We have investigated the genetic diversity and potential mosaic genomes of HIV-1 during the early part of the HIV-1 epidemic among commercial sex workers (CSWs) in Kinshasa, Democratic Republic of Congo (formerly Zaire). Serologic analysis revealed that 27 (28.7%) of the 94 specimens were seropositive by both peptide and whole-virus lysate EIAs and that 24 were positive by molecular screening assays, using generic primers that can detect all known groups of HIV-1. Phylogenetic analyses of the gag(p24), C2V3, and gp41 regions of these 24 specimens showed that all were group M; none of them had any evidence of group O, N, or SIVcpz-like sequences. On the basis of env sequence analysis, the 24 group M specimens were classified as subtypes G (37.5%), A (21%), F1 (12.5%), CRF01_AE (8%), D (4%), and H (4%); 3 (12.5%) were unclassifiable (U). Similar analysis of the gag(p24) region revealed that the majority of infections were subtype A; however, one-third of the specimens were subtype G. Parallel analysis of gag(p24) and env regions revealed discordant subtypes in many specimens that may reflect possible dual and/or recombinant viruses. These data suggest a predominance of subtype G (both pure G and recombinant CRF02_AG) during the early part of the epidemic in Kinshasa. Infections with group N or SIVcpz-like viruses were not present among these CSWs in Kinshasa.
C1 CDC, NCID, DASTLR, HIV Immunol & Diagnost Branch, Atlanta, GA 30333 USA.
   CDC, Retrovirol Branch, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA.
   NIDA, Ctr AIDS & Other Med Consequences Drug Abuse, NIH, Bethesda, MD 20892 USA.
   Project SIDA, Kinshasa, Zaire.
   Inst Trop Med, B-2000 Antwerp, Belgium.
   CDC, AIDS Program, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA.
   NIAID, Lab Immunoregulat, NIH, Baltimore, MD 21205 USA.
RP Lal, RB (reprint author), CDC, NCID, DASTLR, HIV Immunol & Diagnost Branch, Mail Stop D-12,1600 Clifton Rd, Atlanta, GA 30333 USA.
RI Yang, Chunfu/G-6890-2013
NR 22
TC 27
Z9 27
U1 0
U2 0
PU MARY ANN LIEBERT INC PUBL
PI LARCHMONT
PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD MAR
PY 2001
VL 17
IS 4
BP 361
EP 365
DI 10.1089/08892220150503726
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 406KX
UT WOS:000167216300008
PM 11242522
ER

PT J
AU Schulenberg, J
   Maggs, JL
   Long, SW
   Sher, KJ
   Gotham, HJ
   Baer, JS
   Kivlahan, DR
   Marlatt, GA
   Zucker, RA
AF Schulenberg, J
   Maggs, JL
   Long, SW
   Sher, KJ
   Gotham, HJ
   Baer, JS
   Kivlahan, DR
   Marlatt, GA
   Zucker, RA
TI The problem of college drinking: Insights from a developmental
   perspective
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE binge drinking; college drinking; developmental disturbance model;
   alcohol use disorders; alcohol expectancies; brief intervention;
   developmental course
ID BRIEF INTERVENTION; YOUNG ADULTHOOD; BINGE-DRINKING; STUDENTS
AB This article represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. John Schulenberg and Jennifer L. Maggs were Organizers. Stephen W. Long was Chair and provided opening remarks. The presentations were: (1) I'm not a drunk, just a college student: Binge drinking during college as a developmental disturbance, by John Schulenberg; (2) Course of alcohol use disorders during college, by Kenneth J. Sher; (3) How do students experience alcohol and its effects? Positive versus negative expectancies and consequences, by Jennifer L. Maggs; and (4) Brief intervention in the context of developmental trends in college drinking, by G. Alan Marlatt. Critique and commentary were provided by Robert A. Zucker.
C1 Univ Michigan, Inst Social Res, Ann Arbor, MI 48106 USA.
   Univ Michigan, Dept Psychol, Ann Arbor, MI 48106 USA.
   Univ Michigan, Alcohol Res Ctr, Ann Arbor, MI 48106 USA.
   Univ Arizona, Div Family Studies & Human Dev, Tucson, AZ USA.
   NIAAA, Bethesda, MD USA.
   Univ Missouri, Dept Psychol, Columbia, MO USA.
   St Louis VAMC, St Louis, MO USA.
   Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
   Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
   VA Puget Sound Hlth Care Syst, Seattle, WA USA.
RP Schulenberg, J (reprint author), Univ Michigan, Inst Social Res, Ann Arbor, MI 48106 USA.
RI Schulenberg, John/A-2212-2008
OI Schulenberg, John/0000-0003-2129-8486
FU NIAAA NIH HHS [AA06324, R37AA05591, R37AA7231]
NR 15
TC 76
Z9 76
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0145-6008
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD MAR
PY 2001
VL 25
IS 3
BP 473
EP 477
DI 10.1111/j.1530-0277.2001.tb02237.x
PG 5
WC Substance Abuse
SC Substance Abuse
GA 413DH
UT WOS:000167594300021
PM 11290861
ER

PT J
AU King, JR
   Cohen, SG
AF King, JR
   Cohen, SG
TI Asthma among the famous - A continuing series
SO ALLERGY AND ASTHMA PROCEEDINGS
LA English
DT Biographical-Item
ID POLLEN-RELATED ALLERGY
C1 NIAID, NIH, Bethesda, MD 20892 USA.
RP King, JR (reprint author), NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 16
TC 0
Z9 0
U1 0
U2 0
PU OCEAN SIDE PUBLICATIONS INC
PI PROVIDENCE
PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA
SN 1088-5412
J9 ALLERGY ASTHMA PROC
JI Allergy Asthma Proc.
PD MAR-APR
PY 2001
VL 22
IS 2
BP 101
EP 109
DI 10.2500/108854101778250580
PG 9
WC Allergy
SC Allergy
GA 422RL
UT WOS:000168133000009
PM 11332291
ER

PT J
AU Devereux, RB
   Roman, MJ
   Paranicas, M
   Lee, ET
   Welty, TK
   Fabsitz, RR
   Robbins, D
   Rhoades, ER
   Rodeheffer, RJ
   Cowan, LD
   Howard, BV
AF Devereux, RB
   Roman, MJ
   Paranicas, M
   Lee, ET
   Welty, TK
   Fabsitz, RR
   Robbins, D
   Rhoades, ER
   Rodeheffer, RJ
   Cowan, LD
   Howard, BV
TI A population-based assessment of left ventricular systolic dysfunction
   in middle-aged and older adults: The Strong Heart Study
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID PRESSURE-OVERLOAD HYPERTROPHY; AMERICAN-INDIANS; ECHOCARDIOGRAPHIC
   ASSESSMENT; CARDIOVASCULAR-DISEASE; ARTERIAL-HYPERTENSION; MIDWALL
   MECHANICS; RISK-FACTORS; FAILURE; PREVALENCE
AB Background Although clinical congestive heart failure (CHF) is increasingly common, few data document the prevalence and correlates of underlying left ventricular (IV) systolic dysfunction (D) in population-based samples.
   Methods Echocardiography was used in the second Strong Heart Study (SHS) examination to identify mild and severe LVD (LV ejection fraction [EF] 40%-54% and <40%, respectively) in 3184 American Indians.
   Results Mild and severe LVD were more common in men than women (17.4% vs 7.2% and 4.7% vs 1.8%) and in diabetic than nondiabetic participants (12.7% vs 9.1% and 3.5% vs 1.6%). Stepwise increases were observed from participants with normal EF to those with mild and severe LVD in age (mean 60 vs 61 and 63 years, P<.001), prevalence of overt CHF (2% vs 6% and 28%) and definite coronary heart disease (3% vs 11% and 32%), systolic pressure (129 vs 135 and 136 mm Hg), serum creatinine level (0.98 vs 1.34 and 2.16 mg/dL), and log urinary albumin/creatinine level (3.2 vs 3.7 and 4.7); a negative relation was seen with body moss index (31.1 vs 31.0 and 28.4 kg/m(2)) (all P<.001), In multivariate analyses lower LVEFs were independently associated with clinical CHF and coronary heart disease, lower myocardial contractility, male sex, hypertension, overweight, arterial stiffening (higher pulse pressure/stroke volume) and renal dysfunction (higher serum creatinine level), higher LV mass, and lower relative wall thickness.
   Conclusions LVD, present in approximately 14% of middle-aged to elderly adults, is independently associated with overt heart failure and coronary heart disease, male sex, hypertension, overweight, arterial stiffening, and renal target organ damage and, less consistently, with older age and diabetes.
C1 Mayo Clin, Rochester, MN USA.
   Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD USA.
   MedStar Res Inst, Washington, DC USA.
   NHLBI, Bethesda, MD 20892 USA.
   Aberdeen Area Tribal Chairmens Hlth Board, Rapid City, SD USA.
   Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   Cornell Med Ctr, Dept Med, New York, NY USA.
RP Devereux, RB (reprint author), New York Presbyterian Hosp, Div Cardiol, Box 222,525 E 68th St, New York, NY 10021 USA.
FU NCRR NIH HHS [M10RR0047-34]; NHLBI NIH HHS [R01-HL55502, U01-HL41642,
   U01-HL41652, U01-HL41654]
NR 31
TC 57
Z9 60
U1 0
U2 1
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0002-8703
J9 AM HEART J
JI Am. Heart J.
PD MAR
PY 2001
VL 141
IS 3
BP 439
EP 446
DI 10.1067/mhj.2001.113223
PG 8
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 408HW
UT WOS:000167321600022
PM 11231443
ER

PT J
AU Cantor, KP
AF Cantor, KP
TI Invited commentary: Arsenic and cancer of the urinary tract
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Editorial Material
DE arsenic; carcinoma; transitional cell; drinking; incidence; risk
   assessment; urologic neoplasms; water supply
ID DOSE-RESPONSE RELATIONSHIP; DRINKING-WATER; WELL WATER; MALIGNANT
   NEOPLASMS; BLADDER-CANCER; KIDNEY CANCER; ENDEMIC AREA; WEST-BENGAL;
   LUNG-CANCER; MORTALITY
AB Inorganic arsenic in drinking water is a recognized cause of cancers of the skin, lung, and bladder. In the absence of an animal model for studying arsenic carcinogenesis, epidemiologic studies provide the only quantitative data for guiding risk assessment at levels that commonly occur in drinking water. To date, most estimates of risk at low and moderate levels of exposure (<200 <mu>g/liter) have been based on extrapolation from ecologic studies of populations exposed to much higher levels. Epidemiologic data from the prospective cohort study by Chiou et al. that appears in this issue of the Journal (Am J Epidemiol 2001;153:411-18) make an important contribution to improving the precision of the estimated risk of transitional cell carcinoma of the urinary tract associated with ingested arsenic from drinking water. The great strength of the study derives from having individually based measures of exposure and cancer diagnoses. Arsenic in water is a topic of great concern and controversy, and epidemiologic studies will continue to provide crucial information about the risks of cancer and other diseases associated with ingested arsenic.
C1 NCI, Occupat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
RP Cantor, KP (reprint author), NCI, Occupat Epidemiol Branch, Div Canc Epidemiol & Genet, Execut Plaza S,Room 8106,6120 Execut Blvd, Bethesda, MD 20892 USA.
NR 27
TC 16
Z9 16
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAR 1
PY 2001
VL 153
IS 5
BP 419
EP 421
DI 10.1093/aje/153.5.419
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 405YZ
UT WOS:000167189300002
ER

PT J
AU Morrison, JA
   Guo, SMS
   Specker, B
   Chumlea, WC
   Yanovski, SZ
   Yanovski, JA
AF Morrison, JA
   Guo, SMS
   Specker, B
   Chumlea, WC
   Yanovski, SZ
   Yanovski, JA
TI Assessing the body composition of 6-17-year-old black and white girls in
   field studies
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID X-RAY ABSORPTIOMETRY; BIOELECTRICAL-IMPEDANCE ANALYSIS;
   SKINFOLD-THICKNESS MEASUREMENTS; CROSS-VALIDATION; YOUNG-ADULTS;
   CHILDREN; MASS; ANTHROPOMETRY; BIOIMPEDANCE
AB The purpose of the study was to develop ethnic-specific equations for fat-free mass (FFM) from selected anthropometric dimensions and bioelectrical impedance measures of resistance (R) and reactance (X-c) for use in the NHLBI Growth and Heath Study. Using dual-energy X-ray absorptiometry measures of body composition as the dependent variable and field measures of body composition by anthropometry and bioelectrical impedance as the explanatory variables, ethnic-specific prediction equations were developed on a sample of girls representing a wide range of ages and BMI. The equations were cross-validated using (1) the Prediction of Sum of Squares (PRESS) statistic and (2) an independent sample of 20 girls of each race from a study conducted at the National Institute of Child Health and Human Development (NICHD). Subjects were 65 White and 61 Black girls 6-17 years of age. The best race-specific equations for FFM each explained 99% and 97% of the variance in the White and Black girls, respectively. Root mean square errors (RMSE) ranged from 1.14 to 1.95 kg. The equation for Black girls used Stature(2)/Resistance (R), weight, and reactance (X-c) as predictor variables; the equation for White girls used Stature(2)/R, weight, and triceps skinfold thickness. The results indicate that (1) equations to predict FFM in girls should be ethnic specific and that (2) accurate values for TBF and %BF can be calculated from the predicted FFM. Am. J. Hum. Biol. 13:249-254, 2001. (C) 2001 Wiley-Liss, Inc.
C1 Childrens Hosp, Med Ctr, Div Cardiol, Cincinnati, OH 45229 USA.
   Wright State Univ, Div Human Biol, Dept Community Hlth, Dayton, OH 45435 USA.
   Childrens Hosp, Med Ctr, Div Neonatol, Cincinnati, OH 45229 USA.
   NIDDKD, Div Digest Dis & Nutr, NIH, Bethesda, MD 20892 USA.
   NICHHD, Unit Growth & Obes, DEB, NIH, Bethesda, MD 20892 USA.
RP Morrison, JA (reprint author), Childrens Hosp, Med Ctr, Div Cardiol, OSB-4,3333 Burnet Ave, Cincinnati, OH 45229 USA.
OI Specker, Bonny/0000-0003-4759-9957
FU NCRR NIH HHS [M01 RR 08084]; NHLBI NIH HHS [HC-55025, HL-53404]; NIAMS
   NIH HHS [AR 40169]; NICHD NIH HHS [HD12252, HD27063, R01 HD012252]
NR 24
TC 14
Z9 14
U1 0
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 1042-0533
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD MAR-APR
PY 2001
VL 13
IS 2
BP 249
EP 254
DI 10.1002/1520-6300(200102/03)13:2<249::AID-AJHB1035>3.0.CO;2-6
PG 6
WC Anthropology; Biology
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA 401TQ
UT WOS:000166944700015
PM 11460870
ER

PT J
AU Slaugenhaupt, SA
   Blumenfeld, A
   Gill, SP
   Leyne, M
   Mull, J
   Cuajungco, MP
   Liebert, CB
   Chadwick, B
   Idelson, M
   Reznik, L
   Robbins, CM
   Makalowska, I
   Brownstein, MJ
   Krappmann, D
   Scheidereit, C
   Maayan, C
   Axelrod, FB
   Gusella, JF
AF Slaugenhaupt, SA
   Blumenfeld, A
   Gill, SP
   Leyne, M
   Mull, J
   Cuajungco, MP
   Liebert, CB
   Chadwick, B
   Idelson, M
   Reznik, L
   Robbins, CM
   Makalowska, I
   Brownstein, MJ
   Krappmann, D
   Scheidereit, C
   Maayan, C
   Axelrod, FB
   Gusella, JF
TI Tissue-specific expression of a splicing mutation in the IKBKAP gene
   causes familial dysautonomia
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID PROTEIN; LOCALIZATION; CLONING; 9Q31
AB Familial dysautonomia (FD; also known as "Riley-Day syndrome"), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is characterized by widespread sensory and variable autonomic dysfunction. Previously, we had mapped the FD gene, DYS, to a 0.5-cM region on chromosome 9q31 and had shown that the ethnic bias is due to a founder effect, with >99.5% of disease alleles sharing a common ancestral haplotype. To investigate the molecular basis of FD, we sequenced the minimal candidate region and cloned and characterized its five genes. One of these, IKBKAP, harbors two mutations that can cause FD. The major haplotype mutation is located in the donor splice site of intron 20. This mutation can result in skipping of exon 20 in the mRNA of patients with FD, although they continue to express varying levels of wild-type message in a tissue-specific manner. RNA isolated from lymphoblasts of patients is primarily wild-type, whereas only the deleted message is seen in RNA isolated from brain. The mutation associated with the minor haplotype in four patients is a missense (R696P) mutation in exon 19, which is predicted to disrupt a potential phosphorylation site. Our findings indicate that almost all cases of FD are caused by an unusual splice defect that displays tissue-specific expression; and they also provide the basis for rapid carrier screening in the Ashkenazi Jewish population.
C1 Massachusetts Gen Hosp, Mol Neurogenet Unit, Charlestown, MA 02129 USA.
   Harvard Univ, Sch Med, Harvard Inst Human Genet, Boston, MA USA.
   Hadassah Univ Hosp, Dept Clin Biochem, IL-91120 Jerusalem, Israel.
   Hadassah Univ Hosp, Dept Pediat, IL-91120 Jerusalem, Israel.
   NIMH, Genet Lab, NIH, Bethesda, MD 20892 USA.
   NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA.
   NINDS, NIH, Bethesda, MD 20892 USA.
   Max Delbruck Ctr Mol Med, Berlin, Germany.
   NYU Med Ctr, Dept Pediat, New York, NY 10016 USA.
RP Gusella, JF (reprint author), Massachusetts Gen Hosp E, Room 6214,149 13th St, Charlestown, MA 02129 USA.
RI Brownstein, Michael/B-8609-2009; Cuajungco, Math/B-2647-2008; 
OI Cuajungco, Math/0000-0003-0749-9564; Krappmann,
   Daniel/0000-0001-7640-3234
FU NINDS NIH HHS [NS 36326]
NR 21
TC 319
Z9 323
U1 0
U2 17
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAR
PY 2001
VL 68
IS 3
BP 598
EP 605
DI 10.1086/318810
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 402ND
UT WOS:000166994200005
PM 11179008
ER

PT J
AU Saleem, RA
   Banerjee-Basu, S
   Berry, FB
   Baxevanis, AD
   Walter, MA
AF Saleem, RA
   Banerjee-Basu, S
   Berry, FB
   Baxevanis, AD
   Walter, MA
TI Analyses of the effects that disease-causing missense mutations have on
   the structure and function of the winged-helix protein FOXC1
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID TRANSCRIPTION FACTOR GENE; POSITIVE CONTROL; DNA-BINDING; CONGENITAL
   HYDROCEPHALUS; RIEGER-SYNDROME; FORK HEAD; TGF-BETA; MF1; REPRESSOR;
   ACTIVATION
AB Five missense mutations of the winged-helix FOXC1 transcription factor, found in patients with Axenfeld-Rieger (AR) malformations, were investigated for their effects on FOXC1 structure and function. Molecular modeling of the FOXC1 forkhead domain predicted that the missense mutations did not alter FOXC1 structure. Biochemical analyses indicated that, whereas all mutant proteins correctly localize to the cell nucleus, the I87M mutation reduced FOXC1- protein levels. DNA-binding experiments revealed that, although the S82T and S131L mutations decreased DNA binding, the F112S and I126M mutations did not. However, the F112S and I126M mutations decrease the transactivation ability of FOXC1. All the FOXC1 mutations had the net effect of reducing FOXC1 transactivation ability. These results indicate that the FOXC1 forkhead domain contains separable DNA-binding and transactivation functions. In addition, these findings demonstrate that reduced stability, DNA binding, or transactivation, all causing a decrease in the ability of FOXC1 to transactivate genes, can underlie AR malformations.
C1 Univ Alberta, Dept Ophthalmol, Edmonton, AB T6G 2H7, Canada.
   Univ Alberta, Dept Med Genet, Edmonton, AB T6G 2H7, Canada.
   NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA.
RP Walter, MA (reprint author), Univ Alberta, Dept Ophthalmol, Edmonton, AB T6G 2H7, Canada.
NR 37
TC 84
Z9 84
U1 0
U2 3
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAR
PY 2001
VL 68
IS 3
BP 627
EP 641
DI 10.1086/318792
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 402ND
UT WOS:000166994200008
PM 11179011
ER

PT J
AU Galasso, C
   Scire, G
   Fabbri, F
   Spadoni, GL
   Killoran, CE
   Biesecker, LG
   Boscherini, B
AF Galasso, C
   Scire, G
   Fabbri, F
   Spadoni, GL
   Killoran, CE
   Biesecker, LG
   Boscherini, B
TI Long-term treatment with growth hormone improves final height in a
   patient with Pallister-Hall syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE Pallister-Hall syndrome; hypothalamic hamartoma; growth hormone
   neurosecretory dysfunction; growth hormone treatment
ID CONGENITAL HYPOTHALAMIC HAMARTOBLASTOMA; HYPOPITUITARISM; HAMARTOMA
AB Pallister-Hall syndrome is a disorder of development consisting of hypothalamic hamartoma, pituitary dysfunction, central polydactyly and visceral malformations. This disorder is inherited as an autosomal dominant trait and is caused by mutations of the GLI3 gene encoding a zinc finger transcription factor. We describe a case of Pallister-Hall syndrome with growth hormone neurosecretory dysfunction, successfully treated with growth hormone until attainment of final height. We conclude that children with Pallister-Hall syndrome and short stature be evaluated carefully for spontaneous somatotropic function and, if necessary, treated with growth hormone. (C) 2001 Wiley-Liss, Inc.
C1 Univ Roma Tor Vergata, Dept Pediat, Rome, Italy.
   NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD USA.
RP Galasso, C (reprint author), Vle Umanesimo 199, I-00144 Rome, Italy.
NR 19
TC 9
Z9 9
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0148-7299
J9 AM J MED GENET
JI Am. J. Med. Genet.
PD MAR 1
PY 2001
VL 99
IS 2
BP 128
EP 131
DI 10.1002/1096-8628(2001)9999:9999<::AID-AJMG1128>3.0.CO;2-S
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 407BU
UT WOS:000167252200008
PM 11241471
ER

PT J
AU Park, JK
   Koprivica, V
   Andrews, DQ
   Madike, V
   Tayebi, N
   Stone, DL
   Sidransky, E
AF Park, JK
   Koprivica, V
   Andrews, DQ
   Madike, V
   Tayebi, N
   Stone, DL
   Sidransky, E
TI Glucocerebrosidase mutations among African-American patients with type 1
   Gaucher disease
SO AMERICAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE Gaucher disease; glucocerebrosidase; African-American;
   genotype-phenotype correlation; metaxin; recombinant allele; pseudogene
ID GENOTYPE/PHENOTYPE CORRELATIONS; JEWISH PATIENTS; MUTANT ALLELES; GENE;
   COMMON; IDENTIFICATION; POPULATION; PREVALENCE; PROFILE
AB While the inherited deficiency of the enzyme glucocerebrosidase (Gaucher disease) is panethnic in its distribution, there :have not been studies of the mutations encountered in specific ethnic groups in the United States, other than those on Ashkenazi Jews, We present the clinical descriptions and genotypes of seven patients of African-American ancestry with type 1 Gaucher disease, and summarize the published literature regarding the genotypes encountered in this population. All seven of the patients had moderate-to-severe manifestations of the disease, and all developed symptoms by adolescence. Genotypic analyses revealed that no two probands shared the same genotype, The common mutations N370S, c.84-85insG, IVS2+1 G--> A, and R463C were not seen. Mutation L444P was present on one allele in each of the patients: but the same mutation was encountered as a single point mutation in three of the patients, and as part of a recombinant allele in four of the patients. Southern blot analyses revealed a glucocerebrosidase fusion allele in one patient, and a duplication resulting from recombination in the region downstream from the glucocerebrosidase gene in three of the patients. Five different point mutations (A90T, R48W, N117D, R170C, and V352L), one deletion mutation (c.222-224 delTAC), and one insertion mutation (c.153-154 insTACAGC) were encountered. Our results demonstrate that there is significant genotypic heterogeneity among African-American patients with type 1 Gaucher disease, and that recombinations in the glucocerebrosidase gene locus are particularly common in this patient group. Published 2001 Wiley-Liss, Inc.(dagger)
C1 NIMH, Clin Neurosci Branch, NIH, Bethesda, MD 20892 USA.
RP Sidransky, E (reprint author), NIMH, Clin Neurosci Branch, NIH, Bldg 49,Room B1ee16,49 Convent Dr,MSC4405, Bethesda, MD 20892 USA.
NR 31
TC 10
Z9 10
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0148-7299
J9 AM J MED GENET
JI Am. J. Med. Genet.
PD MAR 1
PY 2001
VL 99
IS 2
BP 147
EP 151
DI 10.1002/1096-8628(2001)9999:9999<::AID-AJMG1144>3.0.CO;2-1
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 407BU
UT WOS:000167252200012
PM 11241475
ER

PT J
AU Abbott, KC
   Oliver, JD
   Hypolite, I
   Lepler, LL
   Kirk, AD
   Ko, CW
   Hawkes, CA
   Jones, CA
   Agodoa, LY
AF Abbott, KC
   Oliver, JD
   Hypolite, I
   Lepler, LL
   Kirk, AD
   Ko, CW
   Hawkes, CA
   Jones, CA
   Agodoa, LY
TI Hospitalizations for bacterial septicemia after renal transplantation in
   the United States
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Article
DE septicemia; hospitalization; renal transplant; female; diabetes
   mellitus; urinary tract infection, complications; duration of dialysis;
   rejection; antibody induction; delayed graft function; United States
   Renal Data System
ID URINARY-TRACT INFECTION; PROSPECTIVE-PAYMENT SYSTEM; LONG-TERM SURVIVAL;
   RISK-FACTORS; LIVER-TRANSPLANT; GRAFT FUNCTION; RECIPIENTS; BACTEREMIA;
   MORTALITY; DIALYSIS
AB Background: It is common belief in the transplant community that rates of septicemia in transplant recipients have declined, but this has not been studied in a national population. Methods: Therefore, 33,479 renal transplant recipients in the United States Renal Data System from July 1, 1994 to June 30, 1997 were analyzed in a retrospective registry study of the incidence, associated factors, and mortality of hospitalizations with a primary discharge diagnosis of septicemia (ICD9 Code 038.x). Results: Renal transplant recipients had an adjusted incidence ratio of hospitalizations for septicemia of 41.52 (95% CI 35.45-48.96) compared to the general population. Hospitalizations for septicemia were most commonly associated with urinary tract infection as a secondary diagnosis (30.6%). In multivariate analysis, diabetes and urologic disease, female gender, delayed graft function, rejection, and pre-transplant dialysis, but not induction antibody therapy, were associated with hospitalizations for septicemia. Recipients hospitalized for septicemia had a mean patient survival of 9.03 years (95% CI 7.42-10.63) compared to 15.73 years (95% CI 14.77-16.69) for all other recipients. Conclusions: Even in the modern era, renal transplant recipients remain at high risk for hospitalizations for septicemia, which are associated with substantially decreased patient survival. Newly identified risks in this population were female recipients and pre-transplant dialysis. Copyright (C) 2001 S. KargerAG, Basel.
C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA.
   Walter Reed Army Med Ctr, Pulm Crit Care Serv, Washington, DC 20307 USA.
   Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
   NIDDK, Med Student Res Program, Cleveland, OH USA.
   NIH, Organ Transplantat Serv, Bethesda, MD USA.
   NIDCD, Epidemiol Stat & Data Syst Branch, Bethesda, MD USA.
   NIDDKD, NIH, Bethesda, MD 20892 USA.
RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA.
RI Kirk, Allan/B-6905-2012; 
OI Abbott, Kevin/0000-0003-2111-7112
NR 44
TC 69
Z9 71
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
J9 AM J NEPHROL
JI Am. J. Nephrol.
PD MAR-APR
PY 2001
VL 21
IS 2
BP 120
EP 127
DI 10.1159/000046234
PG 8
WC Urology & Nephrology
SC Urology & Nephrology
GA 434QY
UT WOS:000168828400006
PM 11359019
ER

PT J
AU Patronas, NJ
AF Patronas, NJ
TI Dr Doppman: The lone radiologist - Memorial
SO AMERICAN JOURNAL OF NEURORADIOLOGY
LA English
DT Biographical-Item
C1 NIH, Bethesda, MD 20892 USA.
RP Patronas, NJ (reprint author), NIH, Bldg 10, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC NEURORADIOLOGY
PI OAK BROOK
PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA
SN 0195-6108
J9 AM J NEURORADIOL
JI Am. J. Neuroradiol.
PD MAR
PY 2001
VL 22
IS 3
BP 592
EP 593
PG 2
WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 409VC
UT WOS:000167405500031
ER

PT J
AU Morris, CD
   Jacobson, SL
   Anand, R
   Ewell, MG
   Hauth, JC
   Curet, LB
   Catalano, PM
   Sibai, BM
   Levine, RJ
AF Morris, CD
   Jacobson, SL
   Anand, R
   Ewell, MG
   Hauth, JC
   Curet, LB
   Catalano, PM
   Sibai, BM
   Levine, RJ
TI Nutrient intake and hypertensive disorders of pregnancy: Evidence from a
   large prospective cohort
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE dietary intake; preeclampsia; risk factors
ID SOCIETY CONSENSUS CONFERENCE; HEALTHY NULLIPAROUS WOMEN; RISK-FACTORS;
   FISH-OIL; PREECLAMPSIA; CALCIUM; TRIAL; PREVENTION; SUPPLEMENTATION
AB OBJECTIVE: The objective of this analysis was to prospectively determine the effects of nutrient intakes on the incidences of preeclampsia and pregnancy-associated hypertension among women enrolled in the Calcium for Preeclampsia Prevention study.
   STUDY DESIGN: This was a prospective observational cohort study of women in a randomized clinical trial that included women seeking prenatal care at university medical centers and affiliated clinics and hospitals in 5 US communities. A total of 4589 nulliparous women were recruited between 13 and 21 weeks' gestation. Preeclampsia and pregnancy-associated hypertension were the main outcome measures.
   RESULTS: Preeclampsia was noted in 326 (7.6%) of the 4314 women with known pregnancy outcomes followed up until greater than or equal to 20 weeks' gestation, and pregnancy-associated hypertension was noted in 747 (17.3%). As previously reported, there was no significant difference in these outcomes between cohorts randomly assigned to supplementation with calcium or placebo. By means of logistic regression a baseline risk model was constructed for preeclampsia and pregnancy-associated hypertension. After adjustment for treatment and clinical site, body mass index >26 kg/m(2) and race were significantly associated with an increased risk of preeclampsia. Body mass index greater than or equal to 35 kg/m(2), race, and never smoking were significantly associated with an increased risk of pregnancy-associated hypertension. After adjustment for baseline risks, none of the 28 nutritional factors analyzed were significantly related to either preeclampsia or pregnancy-associated hypertension.
   CONCLUSION: We found no evidence in this study for a significant association of hypertensive disorders of pregnancy with any of the 23 nutrients measured.
C1 Oregon Hlth Sci Univ, Ctr Biomed Informat Commun, Div Med Informat & Outcomes Res, Portland, OR 97201 USA.
   Oregon Hlth Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA.
   Univ Alabama, Dept Obstet & Gynecol, Birmingham, AL 35294 USA.
   NICHHD, Div Epidemiol Stat & Prevent Res, Bethesda, MD 20892 USA.
   Univ New Mexico, Hlth Sci Ctr, Dept Obstet & Gynecol, Albuquerque, NM 87131 USA.
   Metrohlth Med Ctr, Dept Obstet & Gynecol, Cleveland, OH 44109 USA.
   Univ Tennessee, Coll Med, Dept Obstet & Gynecol, Knoxville, TN 37996 USA.
RP Morris, CD (reprint author), Oregon Hlth Sci Univ, Ctr Biomed Informat Commun, Div Med Informat & Outcomes Res, 3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA.
FU NICHD NIH HHS [N01-HD-1-3126, N01-HD-1-3121, N01-HD-2-3154]
NR 23
TC 44
Z9 46
U1 1
U2 3
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD MAR
PY 2001
VL 184
IS 4
BP 643
EP 651
DI 10.1067/mob.2001.111101
PG 9
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 417NP
UT WOS:000167841300020
PM 11262466
ER

PT J
AU Iams, JD
   Goldenberg, RL
   Mercer, BM
   Moawad, AH
   Meis, PJ
   Das, AF
   Caritis, SN
   Miodovnik, M
   Menard, MK
   Thurnau, GR
   Dombrowski, MP
   Roberts, JH
AF Iams, JD
   Goldenberg, RL
   Mercer, BM
   Moawad, AH
   Meis, PJ
   Das, AF
   Caritis, SN
   Miodovnik, M
   Menard, MK
   Thurnau, GR
   Dombrowski, MP
   Roberts, JH
CA Natl I Child Hlth Human Dev Mater
TI The Preterm Prediction Study: Can low-risk women destined for
   spontaneous preterm birth be identified?
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE bishop score; fetal fibronectin; prediction; preterm birth;
   ultrasonography
ID BACTERIAL VAGINOSIS; FETAL FIBRONECTIN; DELIVERY; METRONIDAZOLE; CERVIX;
   TRIAL
AB OBJECTIVE: Half of all preterm births occur in women without clinical risk factors. Our goal was to assess fetal fibronectin assay, Bishop score, and cervical ultrasonography as screening tests to predict which low-risk pregnancies will end in preterm birth.
   STUDY DESIGN: We performed a secondary analysis of data collected at 22 to 24 weeks' gestation from low-risk subjects enrolled in the Preterm Prediction Study, an observational study of risk factors for preterm birth conducted by the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Analysis was limited to primigravid women and to women who did not have a history of preterm birth or spontaneous pregnancy loss at <20 weeks' gestation. Bishop score (<greater than or equal to>4), fetal fibronectin level (greater than or equal to 50 ng/mL), and cervical length (greater than or equal to 25 mm) at 24 weeks' gestation were evaluated alone and in sequence as tests to predict spontaneous delivery before 35 weeks' gestation.
   RESULTS: Of the 2929 subjects enrolled in the original study, 2197 (1207 primigravid women and 900 low-risk multiparous women) met criteria for this analysis. There were 64 spontaneous births before 35 weeks' gestation (3.04%). All three tests were significantly related to birth before 35 weeks' gestation thigh Bishop score: relative risk, 3.6; 95% confidence interval, 2.1-6.3; fetal fibronectin detection: relative risk, 8.2; 95% confidence interval, 4.8-13.9; short cervical length: relative risk, 6.9; 95% confidence interval, 4.3-11.1). However, the sensitivities of the tests alone were low (23.4% for high Bishop score, 23.4% for fetal fibronectin detection, and 39.1% for short cervix), as were the sensitivities for Bishop score followed by cervical ultrasonography (14.1%) and fetal fibronectin assay followed by cervical scan (15.6%).
   CONCLUSION: In the setting of low-risk pregnancy, fetal fibronectin assay and cervical ultrasonography have low sensitivity for preterm birth before 35 weeks' gestation. Sequential screening with Bishop score or fetal fibronectin assay followed by cervical ultrasonography further decreased sensitivity to only 15% among low-risk women.
C1 NICHHD, Bethesda, MD 20892 USA.
RP Iams, JD (reprint author), Ohio State Univ, Med Ctr, Dept Obstet & Gynecol, 5th Floor,Means Hall,1654 Upham Dr, Columbus, OH 43210 USA.
OI caritis, steve/0000-0002-2169-0712
FU NICHD NIH HHS [HD21434, HD21410, HD21414]
NR 13
TC 64
Z9 67
U1 1
U2 4
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD MAR
PY 2001
VL 184
IS 4
BP 652
EP 655
DI 10.1067/mob.2001.111248
PG 4
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 417NP
UT WOS:000167841300021
PM 11262467
ER

PT J
AU Buggage, RR
   Levy-Clarke, GA
   Smith, JA
AF Buggage, RR
   Levy-Clarke, GA
   Smith, JA
TI New corneal findings in human T-cell lymphotrophic virus type 1
   infection
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID I-ASSOCIATED MYELOPATHY; LEUKEMIA-LYMPHOMA; OCULAR MANIFESTATIONS;
   DEPOSITS; DISEASES
AB PURPOSE: Human T-cell lymphotrophic virus type 1 is a RNA retrovirus that primarily affects CD4+ T-cells. Human T-cell lymphotrophic virus type 1 infection is the established cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ T-cells, and two non-neoplastic conditions: human T-cell lymphotrophic virus type 1-associated myelopathy/tropical spastic paraparesis and human T-cell lymphotrophic virus type 1 uveitis. Other reported ophthalmic manifestations of human T-cell lymphotrophic virus type I infection include lymphomatous and leukemic infiltrates in the eye and ocular adnexa in patients with adult T-cell leukemia/lymphoma, retinal pigmentary degeneration, and neuro-ophthalmic disorders in patients with human T-cell lymphotrophic virus type 1-associated myelopathy/tropical spastic paraparesis and keratoconjunctivitis sicca, episcleritis, and sclerouveitis in asymptomatic human T-cell lymphotrophic virus type I carriers. This report describes the ocular findings in three Jamaican patients with human T-cell lymphotrophic virus type 1 infection and adult T-cell leukemia/lymphoma. METHODS: The clinical records of three patients with human T-cell lymphotrophic virus type 1 infection and adult T-cell leukemia/lymphoma examined at the National Eye Institute were reviewed. Each patient had one or more complete ophthalmic evaluations.
   RESULTS: All three patients had corneal abnormalities, including corneal haze and central opacities with thinning; bilateral immunoprotein keratopathy; and peripheral corneal thinning, scarring, and neovascularization. All three patients had elevated serum immunoglobulin levels.
   CONCLUSIONS: We believe that the novel corneal findings in these patients are most likely a consequence of the hypergammaglobulinemia induced by the human T-cell lymphotrophic virus type 1 infection or the T-cell malignancy. (Am J Ophthalmol 2001;131:309-313. (C) 2001 by Elsevier Science Inc. All rights reserved.).
C1 NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
RP Buggage, RR (reprint author), NEI, Immunol Lab, NIH, 10 Ctr Dr,Bldg 10,Room 10 N112, Bethesda, MD 20892 USA.
NR 23
TC 14
Z9 14
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0002-9394
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2001
VL 131
IS 3
BP 309
EP 313
DI 10.1016/S0002-9394(00)00881-3
PG 5
WC Ophthalmology
SC Ophthalmology
GA 408QP
UT WOS:000167339400004
PM 11239862
ER

PT J
AU Silveira, C
   Belfort, R
   Muccioli, C
   Abreu, MT
   Martins, MC
   Victoria, C
   Nussenblatt, RB
   Holland, GN
AF Silveira, C
   Belfort, R
   Muccioli, C
   Abreu, MT
   Martins, MC
   Victoria, C
   Nussenblatt, RB
   Holland, GN
TI A follow-up study of Toxoplasma gondii infection in southern Brazil
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID OCULAR TOXOPLASMOSIS
AB PURPOSE: To understand better the natural history of ocular toxoplasmosis by reexamining a well characterized population in Southern Brazil,
   METHODS: Ophthalmological examination and serologic tests for Toxoplasma gondii infection were performed in 1997 on 383 individuals who had undergone the same evaluation in 1990.
   RESULTS: Of 109 seronegative subjects in 1990, 21 (19.3%) became seropositive by 1997, and 2 (1.5% of previously seronegative patients; 9.5% of those known to have seroconverted) developed ocular toxoplasmosis. Seroconversion occurred more frequently in individuals under 17 years of age (16 of 46 patients, 34.8%) than in those greater than 17 years of age (5 of 63 patients, 7.9%; p = 0.002), Of 131 seropositive individuals who did not have ocular lesions in 1990, 11 (8.3%) had typical toxoplasmic lesions in 1997, Of the 13 individuals with non-specific hyperpigmented small retinal lesions in 1990, 3 (23%) presented with typical lesions in 1997.
   CONCLUSIONS: Acquired T. gondii infection can result in late development of ocular lesions. Small, non-specific hyperpigmented retinal lesions may represent sites of T. gondii infection in seropositive individuals, (Am J Ophthalmol 2001;131:351-354, (C) 2001 by Elsevier Science Inc. All rights reserved.).
C1 Clin Silveira, Erechim, RS, Brazil.
   Univ Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol, Sao Paulo, Brazil.
   Fed Univ Pelotas, Pelotas, Brazil.
   NEI, NIH, Bethesda, MD 20892 USA.
   Univ Calif Los Angeles, Sch Med, Ocular Inflammatory Dis Ctr, Los Angeles, CA USA.
   Univ Calif Los Angeles, Sch Med, Jules Stein Eye Inst, Los Angeles, CA USA.
   Univ Calif Los Angeles, Sch Med, Dept Ophthalmol, Los Angeles, CA USA.
RP Belfort, R (reprint author), Rua Botucatu 822, BR-04023062 Sao Paulo, Brazil.
RI Belfort Jr, Rubens/E-2252-2012; Muccioli, Cristina/C-3419-2013; 
OI Belfort Jr, Rubens/0000-0002-8422-3898; Victora,
   Cesar/0000-0002-2465-2180
NR 6
TC 78
Z9 85
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0002-9394
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2001
VL 131
IS 3
BP 351
EP 354
DI 10.1016/S0002-9394(00)00830-8
PG 4
WC Ophthalmology
SC Ophthalmology
GA 408QP
UT WOS:000167339400010
PM 11239868
ER

PT J
AU Buggage, RR
   Smith, JA
   Shen, DF
   Chan, CC
AF Buggage, RR
   Smith, JA
   Shen, DF
   Chan, CC
TI Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus
   infection
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID GENE REARRANGEMENTS
AB PURPOSE: To examine the cause of adult T-cell leukemia/ lymphoma.
   METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction.
   RESULTS: Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma,
   CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes. (Am J Ophthalmol 2001;131:381-383, (C) 2001 by Elsevier Science Inc. All rights reserved.).
C1 NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
RP Buggage, RR (reprint author), NEI, Immunol Lab, NIH, 10 Ctr Dr,Bldg 10,Room 10 N112, Bethesda, MD 20892 USA.
NR 7
TC 8
Z9 8
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0002-9394
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2001
VL 131
IS 3
BP 381
EP 383
DI 10.1016/S0002-9394(00)00865-5
PG 3
WC Ophthalmology
SC Ophthalmology
GA 408QP
UT WOS:000167339400018
PM 11239876
ER

PT J
AU Fine, HF
   Smith, JA
   Murante, BL
   Nussenblatt, RB
   Robinson, MR
AF Fine, HF
   Smith, JA
   Murante, BL
   Nussenblatt, RB
   Robinson, MR
TI Frosted branch angiitis in a child with HIV infection
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CYTOMEGALOVIRUS RETINITIS; RETINAL
   PERIPHLEBITIS
AB PURPOSE: In adults with human immunodeficiency virus (HIV) infection, frosted branch angiitis is commonly associated with cytomegalovirus retinitis and responds to anti-cytomegalovirus therapy. We describe the first pediatric case of HIV-associated frosted branch angiitis.
   METHODS: Case report.
   RESULTS: A 7-year-old HIV-infected male with frosted branch angiitis was refractory to induction doses of intravenous ganciclovir and foscarnet over a 2-month period. Although cytomegalovirus antigenemia resolved, the angiitis only improved after subsequent treatment with systemic corticosteroids,
   CONCLUSION: Frosted branch angiitis in this patient was not attributed to cytomegalovirus. The pathogenesis of HIV-associated frosted branch angiitis may differ between children and adults. (Am J Ophthalmol 2001; 131:394-396, (C) 2001 by Elsevier Science Inc. All rights reserved.).
C1 NEI, Clin Res Training Program, NIH, Bethesda, MD 20892 USA.
   NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   Univ Rochester, Strong Mem Hosp, Childrens Hosp Strong, Dept Pediat Infect Dis, Rochester, NY 14642 USA.
   NEI, Off Clin Director, NIH, Bethesda, MD 20892 USA.
RP Fine, HF (reprint author), NEI, Clin Res Training Program, NIH, 10-10N112,10 Ctr Dr,MSC 1863, Bethesda, MD 20892 USA.
NR 5
TC 9
Z9 16
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0002-9394
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2001
VL 131
IS 3
BP 394
EP 396
DI 10.1016/S0002-9394(00)00792-3
PG 3
WC Ophthalmology
SC Ophthalmology
GA 408QP
UT WOS:000167339400026
PM 11239884
ER

PT J
AU Velez, G
   Roy, CE
   Whitcup, SM
   Chan, CC
   Robinson, MR
AF Velez, G
   Roy, CE
   Whitcup, SM
   Chan, CC
   Robinson, MR
TI High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus
   retinitis
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID VIRUS RETINITIS
AB PURPOSE: To describe the chronic use of high doses of intravitreal ganciclovir, in combination with foscarnet, for the treatment of cytomegalovirus retinitis,
   METHODS: A 31-year-old man with human immunodeficiency virus (HIV) infection and unilateral active cytomegalovirus retinitis was treated with escalating intravitreal injections of ganciclovir (up to 3.0 mg twice a week) in combination with foscarnet (up to 2.4 mg twice a week) over the course of approximately 1 year.
   RESULTS: Complete regression of the retinitis was obtained with high doses of intravitreal ganciclovir and foscarnet. Visual acuity in the affected eye remained 20/20 throughout the course of therapy. No ganciclovir retinal toxicity was identified.
   CONCLUSION: High doses of intravitreal ganciclovir in combination with foscarnet can be well tolerated and may be required to successfully control cytomegalovirus retinitis in some patients, (Am J Ophthalmol 2001;131: 396-397, (C) 2001 by Elsevier Science inc, All rights reserved.).
C1 NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   NEI, Off Clin Director, NIH, Bethesda, MD 20892 USA.
RP Velez, G (reprint author), 9918 Marquette Dr, Bethesda, MD 20817 USA.
NR 5
TC 11
Z9 14
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0002-9394
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2001
VL 131
IS 3
BP 396
EP 397
DI 10.1016/S0002-9394(00)00785-6
PG 2
WC Ophthalmology
SC Ophthalmology
GA 408QP
UT WOS:000167339400027
PM 11239885
ER

PT J
AU Ivanov, S
   Liao, SY
   Ivanova, A
   Danilkovitch-Miagkova, A
   Tarasova, N
   Weirich, G
   Merrill, MJ
   Proescholdt, MA
   Oldfield, EH
   Lee, J
   Zavada, J
   Waheed, A
   Sly, W
   Lerman, MI
   Stanbridge, EJ
AF Ivanov, S
   Liao, SY
   Ivanova, A
   Danilkovitch-Miagkova, A
   Tarasova, N
   Weirich, G
   Merrill, MJ
   Proescholdt, MA
   Oldfield, EH
   Lee, J
   Zavada, J
   Waheed, A
   Sly, W
   Lerman, MI
   Stanbridge, EJ
TI Expression of hypoxia-lnducible cell-surface transmembrane carbonic
   anhydrases in human cancer
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID TUMOR-SUPPRESSOR PROTEIN; DIAGNOSTIC BIOMARKER; MN ANTIGEN; PAPANICOLAOU
   SMEARS; CERVICAL DYSPLASIA; MN/CA9 PROTEIN; HUMAN GUT; CARCINOMA;
   IDENTIFICATION; KIDNEY
AB An acidic extracellular pH is a fundamental property of the malignant phenotype. In von Hippel-Lindau (VHL)-defective tumors the cell surface transmembrane carbonic anhydrase (CA) CA9 and CA12 genes are overexpressed because of the absence of pVHL. We hypothesized that these enzymes might be involved in maintaining the extracellular acidic pH in tumors, thereby providing a conducive environment for tumor growth and spread. Using Northern blot analysis and immunostaining with specific antibodies we analyzed the expression of CA9 and CA12 genes and their products in a large sample of cancer cell lines, fresh and archival tumor specimens, and normal human tissues. Expression was also analyzed in cultured cells under hypoxic conditions. Expression of CA IX and CA XII in normal adult tissues was detected only in highly specialized cells and for most tissues their expression did not overlap. Analysis of RNA samples isolated from 87 cancer cell lines and 18 tumors revealed high-to-moderate levels of expression of CA9 and CA12 in multiple cancers. Immunohistochemistry revealed high-to-moderate expression of these enzymes in various normal tissues and multiple common epithelial tumor types. The immunostaining was seen predominantly on the cell surface membrane. The expression of both genes was markedly induced under hypoxic conditions in tumors and cultured tumor cells. We conclude that the cell surface trans-membrane carbonic anhydrases CA IX and CA XII are overexpressed in many tumors suggesting that this is a common feature of cancer cells that may be required for tumor progression. These enzymes may contribute to the tumor microenvironment by maintaining extracellular acidic pH and helping cancer cells grow and metastasize. Our studies show an important causal link between hypoxia, extracellular acidification, and induction or enhanced expression of these enzymes in human tumors.
C1 Sci Applicat Int Corp, Immunobiol Lab, Frederick, MD USA.
   Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD USA.
   NCI, Mol Aspects Drug Design Sect, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA.
   NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
   Univ Calif Irvine, Coll Med, Dept Microbiol & Mol Genet, Irvine, CA 92717 USA.
   St Louis Univ, Sch Med, St Louis, MO USA.
   Acad Sci Czech Republ, Prague, Czech Republic.
RP Ivanov, S (reprint author), NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Frederick Lab Immunol, Bldg 560,POB B, Frederick, MD 21702 USA.
FU NCI NIH HHS [CA19401, N01-CO-56000]
NR 52
TC 397
Z9 420
U1 5
U2 27
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAR
PY 2001
VL 158
IS 3
BP 905
EP 919
DI 10.1016/S0002-9440(10)64038-2
PG 15
WC Pathology
SC Pathology
GA 409XN
UT WOS:000167411100015
PM 11238039
ER

PT J
AU Bezerra, JA
   Currier, AR
   Melin-Aldana, H
   Sabla, G
   Bugge, TH
   Kombrinck, KW
   Degen, JL
AF Bezerra, JA
   Currier, AR
   Melin-Aldana, H
   Sabla, G
   Bugge, TH
   Kombrinck, KW
   Degen, JL
TI Plasminogen activators direct reorganization of the liver lobule after
   acute injury
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID HEPATOCYTE GROWTH-FACTOR; DEFICIENT MICE; UROKINASE RECEPTOR;
   PARTIAL-HEPATECTOMY; RAT-LIVER; REGENERATION; GENE; BETA; THROMBOSIS;
   TGF-BETA-1
AB Tissue repair requires an adequate cellular proliferation coordinated with the timely proteolysis of matrix elements, Based on the properties of plasminogen activators in liver cell proliferation and tissue proteolysis, we explored the regulatory role of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) in liver repair. Using carbon tetrachloride (CCl4) intoxication as a model of acute liver injury, we found that tPA-deficient mice displayed a mild defect in hepatic repair, whereas livers of uPA-deficient mice had a more substantial delay in repair, with injury of centrilobular hepatocytes persisting up to 14 days after CCl4. Notably, functional cooperativity between plasminogen activators was strongly inferred from the profound reparative defect in livers of mice lacking tPA and uPA simultaneously, with persistence of centrilobular injury as far out as 35 days. The defective repair was not because of increased susceptibility of experimental mice to the toxin or to inadequate cellular proliferation. Instead, lack of plasminogen activators led to the accumulation of fibrin and fibronectin within injured areas and poor removal of necrotic cells. These data demonstrate that tPA and uPA play a critical role in hepatic repair via proteolysis of matrix elements and clearance of cellular debris from the field of injury.
C1 Childrens Hosp Res Fdn, Div Gastroenterol & Nutr, Cincinnati, OH 45229 USA.
   Childrens Hosp Res Fdn, Div Pathol, Cincinnati, OH 45229 USA.
   Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA.
   Univ Cincinnati, Dept Pediat, Cincinnati, OH 45221 USA.
   Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD USA.
RP Bezerra, JA (reprint author), Childrens Hosp, Med Ctr, Div Gastroenterol & Nutr, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
FU NHLBI NIH HHS [HL 47826]; NIDDK NIH HHS [DK 55710, R01 DK055710]
NR 44
TC 64
Z9 69
U1 0
U2 0
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAR
PY 2001
VL 158
IS 3
BP 921
EP 929
DI 10.1016/S0002-9440(10)64039-4
PG 9
WC Pathology
SC Pathology
GA 409XN
UT WOS:000167411100016
PM 11238040
ER

PT J
AU Schwesinger, C
   Yee, C
   Rohan, RM
   Joussen, AM
   Fernandez, A
   Meyer, TN
   Poulaki, V
   Ma, JJK
   Redmond, TM
   Liu, SY
   Adamis, AP
   D'Amato, RJ
AF Schwesinger, C
   Yee, C
   Rohan, RM
   Joussen, AM
   Fernandez, A
   Meyer, TN
   Poulaki, V
   Ma, JJK
   Redmond, TM
   Liu, SY
   Adamis, AP
   D'Amato, RJ
TI Intrachoroidal neovascularization in transgenic mice overexpressing
   vascular endothelial growth factor in the retinal pigment epithelium
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID SUBFOVEAL FIBROVASCULAR MEMBRANES; KRYPTON LASER PHOTOCOAGULATION;
   EXPRESSION IN-VIVO; MACULAR DEGENERATION; SUBRETINAL NEOVASCULARIZATION;
   CHOROIDAL NEOVASCULARIZATION; PERMEABILITY FACTOR; TYROSINE KINASE;
   BRUCHS MEMBRANE; ANGIOGENESIS
AB Choroidal neovascularization in age-related macular degeneration is a frequent and poorly treatable cause of vision loss in elderly Caucasians. This choroidal neovascularization has been associated with the expression of vascular endothelial growth factor (VEGF). In current animal models choroidal neovascularization is induced by subretinal injection of growth factors or vectors encoding growth factors such as VEGF, or by disruption of the Bruch's membrane/retinal pigment epithelium complex with laser treatment. We wished to establish a transgenic murine model of age-related macular degeneration, in which the overexpression of VEGF by the retinal pigment epithelium induces choroidal neovascularization. A construct consisting of a tissue-specific murine retinal pigment epithelium promoter (RPE65 promoter) coupled to murine VEGF(164) cDNA with a rabbit beta -globin-3' UTR was introduced into the genome of albino mice. Transgene mRNA was expressed in the retinal pigment epithelium at all ages peaking at 4 months. The expression of VEGF protein was increased in both the retinal pigment epithelium and choroid. An increase of intravascular adherent leukocytes and vessel leakage was observed. Histopathology revealed intrachoroidal neovascularization that did not penetrate through an intact Bruch's membrane. These results support the hypothesis that additional insults to the integrity of Bruch's membrane are required to induce growth of choroidal vessels into the subretinal space as seen in age-related macular degeneration. This model may be useful to screen for inhibitors of choroidal vessel growth.
C1 Childrens Hosp, Surg Res Lab, Boston, MA 02115 USA.
   Univ Freiburg, Freiburg, Germany.
   Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA USA.
   Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
   NEI, Retinal Cell & Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP D'Amato, RJ (reprint author), Childrens Hosp, Surg Res Lab, Enders Bldg 1006,300 Longwood Ave, Boston, MA 02115 USA.
OI Redmond, T. Michael/0000-0002-1813-5291
NR 52
TC 148
Z9 156
U1 1
U2 9
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAR
PY 2001
VL 158
IS 3
BP 1161
EP 1172
DI 10.1016/S0002-9440(10)64063-1
PG 12
WC Pathology
SC Pathology
GA 409XN
UT WOS:000167411100040
PM 11238064
ER

PT J
AU Boateng, SY
   Naqvi, RU
   Koban, MU
   Yacoub, MH
   MacLeod, KT
   Boheler, KR
AF Boateng, SY
   Naqvi, RU
   Koban, MU
   Yacoub, MH
   MacLeod, KT
   Boheler, KR
TI Low-dose ramipril treatment improves relaxation and calcium cycling
   after established cardiac hypertrophy
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE myocytes; Na+/Ca2+ exchanger; sarcoplasmic reticulum; ATPase; mRNA;
   protein abundance
ID CONVERTING ENZYME-INHIBITION; PRESSURE-OVERLOAD HYPERTROPHY;
   LEFT-VENTRICULAR HYPERTROPHY; FAILING HUMAN MYOCARDIUM; HUMAN
   HEART-FAILURE; NA-CA EXCHANGE; SARCOPLASMIC-RETICULUM; GENE-EXPRESSION;
   GUINEA-PIG; NA+-CA2+ EXCHANGER
AB Rapid cooling contractures were used in this study to test whether low-dose ramipril improves sarcoplasmic reticulum (SR) Ca2+ uptake and Na+/Ca2+ exchanger function in isolated hypertrophied rat myocytes. Compensated cardiac hypertrophy was induced by abdominal aortic constriction for 5 wk followed by administration of ramipril (50 mug.kg(-1).day(-1)) or vehicle for 4 wk. Myocyte cell length and cell width were significantly (P < 0.05) increased in both hypertrophied groups (+/-ramipril). Myocytes were loaded with indo 1, and relaxation was investigated after rapid cooling. Hypertrophied myocyte relaxation in Na+-free/Ca2+-free solution was 63% slower (P < 0.01) and the fall in intracellular Ca2+ was 60% slower (P < 0.05) than the relaxation of control cells. After ramipril treatment both relaxation and the decline in intracellular Ca2+ returned to control rates through improved SR Ca2+-ATPase function. Relaxation in caffeine showed no change after hypertrophy; however, after ramipril treatment the time to 50% relaxation in caffeine decreased by 30% (P < 0.05). The improvement in Ca2+ extrusion across the sarcolemmal membrane occurred independently of changes in Na+/Ca2+ exchanger mRNA and protein abundance. These data demonstrate that ramipril improves both SR-dependent and non-SR-dependent calcium cycling after established cardiac hypertrophy. However, the improvements in function are independent of transcriptional activation and likely to involve altered intracellular ion concentrations.
C1 NIA, Mol Cardiol Unit, NIH, Lab Cardiovasc Sci,Gerontol Res Ctr, Baltimore, MD 21224 USA.
   Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Dept Cardiothorac Surg, London SW3 6LY, England.
   Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
RP Boheler, KR (reprint author), NIA, Mol Cardiol Unit, NIH, Lab Cardiovasc Sci,Gerontol Res Ctr, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 44
TC 10
Z9 10
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2001
VL 280
IS 3
BP H1029
EP H1038
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
SC Cardiovascular System & Cardiology; Physiology
GA 402GN
UT WOS:000166978000013
PM 11179044
ER

PT J
AU Boehm, EA
   Jones, BE
   Radda, GK
   Veech, RL
   Clarke, K
AF Boehm, EA
   Jones, BE
   Radda, GK
   Veech, RL
   Clarke, K
TI Increased uncoupling proteins and decreased efficiency in
   palmitate-perfused hyperthyroid rat heart
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE isolated mitochondria; cardiac efficiency
ID SKELETAL-MUSCLE; GENE-EXPRESSION; THYROID-HORMONE;
   OXIDATIVE-PHOSPHORYLATION; CARDIAC MYOSIN; ADIPOSE-TISSUE;
   MESSENGER-RNA; MITOCHONDRIA; MECHANISM; THERMOGENESIS
AB The physiological role of mitochondrial uncoupling proteins (UCPs) in heart and skeletal muscle is unknown, as is whether mitochondrial uncoupling of oxidative phosphorylation by fatty acids occurs in vivo. In this study, we found that UCP2 and UCP3 protein content, determined using Western blotting, was increased by 32 and 48%, respectively, in hyperthyroid rat heart mitochondria. Oligomycin-insensitive respiration rate, a measure of mitochondrial uncoupling, was increased in all mitochondria in the presence of palmitate: 36% in controls and 71 and 100% with 0.8 and 0.9 mM palmitate, respectively, in hyperthyroid rat heart mitochondria. In the isolated working heart, 0.4 mM palmitate significantly lowered cardiac output by 36% and cardiac efficiency by 38% in the hyperthyroid rat heart. Thus increased mitochondrial UCPs in the hyperthyroid rat heart were associated with increased uncoupling and decreased myocardial efficiency in the presence of palmitate. In conclusion, a physiological effect of UCPs on fatty acid oxidation has been found in heart at the mitochondrial and whole organ level.
C1 Univ Oxford, Dept Biochem, Oxford OX1 3QU, England.
   NIAAA, Lab Membrane Biochem & Biophys, Rockville, MD 20852 USA.
RP Boehm, EA (reprint author), Univ Oxford, Dept Biochem, S Parks Rd, Oxford OX1 3QU, England.
NR 43
TC 90
Z9 92
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2001
VL 280
IS 3
BP H977
EP H983
PG 7
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
SC Cardiovascular System & Cardiology; Physiology
GA 402GN
UT WOS:000166978000007
PM 11179038
ER

PT J
AU McElroy, SL
   Altshuler, LL
   Suppes, T
   Keck, PE
   Frye, MA
   Denicoff, KD
   Nolen, WA
   Kupka, RW
   Leverich, GS
   Rochussen, JR
   Rush, AJ
   Post, RM
AF McElroy, SL
   Altshuler, LL
   Suppes, T
   Keck, PE
   Frye, MA
   Denicoff, KD
   Nolen, WA
   Kupka, RW
   Leverich, GS
   Rochussen, JR
   Rush, AJ
   Post, RM
TI Axis I psychiatric comorbidity and its relationship to historical
   illness variables in 288 patients with bipolar disorder
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID OBSESSIVE-COMPULSIVE DISORDER; SUBSTANCE-ABUSE; CO-MORBIDITY; DSM-III;
   1ST HOSPITALIZATION; GENERAL-POPULATION; MENTAL-DISORDERS; EATING
   DISORDER; PANIC DISORDER; MANIC PATIENTS
AB Objective: Bipolar disorder often co-occurs with other axis I disorders, but little is known about the relationships between the clinical features of bipolar illness and these comorbid conditions. Therefore, the authors assessed comorbid lifetime and current axis I disorders in 288 patients with bipolar disorder and the relationships of these comorbid disorders to selected demographic and historical illness variables.
   Method: They evaluated 288 outpatients with bipolar I or II disorder, using structured diagnostic interviews and clinician-administered and self-rated questionnaires to determine the diagnosis of bipolar disorder, comorbid axis I disorder diagnoses, and demographic and historical illness characteristics.
   Results: One hundred eighty-seven (65%) of the patients with bipolar disorder also met DSM-IV criteria for at least one comorbid lifetime axis I disorder. More patients had comorbid anxiety disorders (N=78, 42%) and substance use disorders (N=78, 42%) than had eating disorders (N=9, 5%). There were no differences in comorbidity between patients with bipolar I and bipolar II disorder. Both lifetime axis I comorbidity and current axis I comorbidity were associated with earlier age at onset of affective symptoms and syndromal bipolar disorder. Current axis I comorbidity was associated with a history of development of both cycle acceleration and more severe episodes over time.
   Conclusions: Patients with bipolar disorder often have comorbid anxiety, substance use, and, to a lesser extent, eating disorders. Moreover, axis I comorbidity, especially current comorbidity, may be associated with an earlier age at onset and worsening course of bipolar illness. Further research into the prognostic and treatment response implications of axis I comorbidity in bipolar disorder is important and is in progress.
C1 Acad Hosp, Utrecht, Netherlands.
   Willem Arntsz Huis, HC Rumke Grp, Utrecht, Netherlands.
   NIMH, Biol Psychiat Branch, Bethesda, MD 20892 USA.
   SW Med Ctr, Dallas, TX USA.
   W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA.
   Inst Neuropsychiat, Los Angeles, CA USA.
   Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
   Univ Cincinnati, Coll Med, Biol Psychiat Program, Cincinnati, OH 45267 USA.
RP McElroy, SL (reprint author), Univ Cincinnati, Coll Med, Biol Psychiat Program, POB 670559,231 Bethesda Ave, Cincinnati, OH 45267 USA.
RI Nolen, Willem/E-9006-2014; 
OI Rush, Augustus/0000-0003-2004-2382
NR 46
TC 439
Z9 450
U1 4
U2 39
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST, N W, STE 1101, WASHINGTON, DC 20005 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD MAR
PY 2001
VL 158
IS 3
BP 420
EP 426
DI 10.1176/appi.ajp.158.3.420
PG 7
WC Psychiatry
SC Psychiatry
GA 408JL
UT WOS:000167323000013
PM 11229983
ER

PT J
AU Malaspina, D
   Goetz, RR
   Friedman, JH
   Kaufmann, CA
   Faraone, SV
   Tsuang, M
   Cloninger, CR
   Nurnberger, JI
   Blehar, MC
AF Malaspina, D
   Goetz, RR
   Friedman, JH
   Kaufmann, CA
   Faraone, SV
   Tsuang, M
   Cloninger, CR
   Nurnberger, JI
   Blehar, MC
TI Traumatic brain injury and schizophrenia in members of schizophrenia and
   bipolar disorder pedigrees
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID NEUROLOGIC SIGNS; HEAD-INJURY; RELATIVES; DEPRESSION; PSYCHOSIS;
   GENOTYPE; SEQUELAE; FAMILY; ONSET
AB Objective: Schizophrenia following a traumatic brain injury could be a phenocopy of genetic schizophrenia or the consequence of a gene-environment interaction. Alternatively, traumatic brain injury and schizophrenia could be spuriously associated if those who are predisposed to develop schizophrenia have greater amounts of trauma for other reasons. The authors investigated the relationship between traumatic brain injury and psychiatric diagnoses in a large group of subjects from families with at least two biologically related first-degree relatives with schizophrenia, schizoaffective disorder, or bipolar disorder.
   Method: The Diagnostic Interview for Genetic Studies was used to determine history of traumatic brain injury and diagnosis for 1,275 members of multiplex bipolar disorder pedigrees and 565 members of multiplex schizophrenia pedigrees.
   Results: Rates of traumatic brain injury were significantly higher for those with a diagnosis of schizophrenia, bipolar disorder, and depression than for those with no mental illness. However, multivariate analysis of within-pedigree data showed that mental illness was related to traumatic brain injury only in the schizophrenia pedigrees. Independent of diagnoses, family members of those with schizophrenia were more likely to have had traumatic brain injury than were members of the bipolar disorder pedigrees. The members of the schizophrenia pedigrees also failed to show the gender difference for traumatic brain injury (more common in men than in women) that was expected and was present in the bipolar disorder pedigrees. Subjects with a schizophrenia diagnosis who were members of the bipolar disorder pedigrees land thus had less genetic vulnerability to schizophrenia) were less likely to have had traumatic brain injury (4.5%) than were subjects with schizophrenia who were members of the schizophrenia pedigrees land who had greater genetic vulnerability to schizophrenia) (19.6%).
   Conclusions: Members of the schizophrenia pedigrees, even those without a schizophrenia diagnosis, had greater exposure to traumatic brain injury com pared to members of the bipolar disorder pedigrees. Within the schizophrenia pedigrees, traumatic brain injury was associated with a greater risk of schizophrenia, consistent with synergistic effects between genetic vulnerability for schizophrenia and traumatic brain injury. Posttraumatic-brain-injury schizophrenia in mu[tip[ex schizophrenia pedigrees does not appear to be a phenocopy of the genetic disorder.
C1 New York State Psychiat Inst, New York, NY 10032 USA.
   Columbia Univ, New York, NY 10027 USA.
   Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   Washington Univ, Dept Psychiat, St Louis, MO USA.
   NIMH, Bethesda, MD 20892 USA.
   Indiana Univ, Dept Psychiat, Indianapolis, IN 46204 USA.
RP Malaspina, D (reprint author), New York State Psychiat Inst, 722 W 168th St, New York, NY 10032 USA.
RI Cloninger, Claude/F-5357-2012; 
OI Cloninger, Claude/0000-0003-3096-4807; Nurnberger,
   John/0000-0002-7674-1767; Faraone, Stephen/0000-0002-9217-3982
FU NIMH NIH HHS [MH-46289, MH-50727]
NR 41
TC 75
Z9 79
U1 3
U2 9
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST, N W, STE 1101, WASHINGTON, DC 20005 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD MAR
PY 2001
VL 158
IS 3
BP 440
EP 446
DI 10.1176/appi.ajp.158.3.440
PG 7
WC Psychiatry
SC Psychiatry
GA 408JL
UT WOS:000167323000016
PM 11229986
ER

PT J
AU Helfand, WH
   Lazarus, J
   Theerman, P
AF Helfand, WH
   Lazarus, J
   Theerman, P
TI Dr Button and the airplane
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
C1 Natl Lib Med, Hist Med Div, Bethesda, MD 20894 USA.
RP Theerman, P (reprint author), Natl Lib Med, Hist Med Div, 8600 Rockville Pike, Bethesda, MD 20894 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAR
PY 2001
VL 91
IS 3
BP 354
EP 354
DI 10.2105/AJPH.91.3.354
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 461BL
UT WOS:000170345000002
PM 11236395
ER

PT J
AU Singh, GK
   Siahpush, M
AF Singh, GK
   Siahpush, M
TI All-cause and cause-specific mortality of immigrants and native born in
   the United States
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID NATIONAL LONGITUDINAL MORTALITY; CANCER MORTALITY; AUSTRALIA; CANADA;
   POPULATION; RESIDENTS; AMERICAN; SUICIDE; HEALTH; WOMEN
AB Objectives. This study examined whether US-born people and immigrants 25 years or older differ in their risks of all-cause and cause-specific mortality and whether these differentials, if they exist, vary according to age, sex, and race/ethnicity.
   Methods. Using data from the National Longitudinal Mortality Study ( 1979-1989), we derived mortality risks of immigrants relative to those of US-born people by using a Cox regression model after adjusting for age, race/ethnicity, marital status, urban/rural residence, education, occupation, and family income.
   Results. Immigrant men and women had, respectively, an 18% and 13% lower risk of overall mortality than their US-born counterparts. Reduced mortality risks were especially pronounced for younger and for Black and Hispanic immigrants. Immigrants showed significantly lower risks of mortality from cardiovascular diseases, lung and prostate cancer, chronic obstructive pulmonary diseases, cirrhosis, pneumonia and influenza, unintentional injuries, and suicide but higher risks of mortality from stomach and brain cancer and infectious diseases.
   Conclusions. Mortality patterns for immigrants and for US-born people vary considerably, with immigrants experiencing lower mortality from several major causes of death. Future research needs to examine the role of sociocultural and behavioral factors in explaining the mortality advantage of immigrants.
C1 Anti Canc Council Victoria, Canc Control Res Inst, VicHlth Ctr Tobacco Control, Carlton, Vic, Australia.
   NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
RP Singh, GK (reprint author), NCI, Div Canc Control & Populat Sci, NIH, Suite 343,6130 Execut Blvd,Execut Plaza N,MSC 735, Bethesda, MD 20892 USA.
NR 39
TC 252
Z9 255
U1 1
U2 15
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAR
PY 2001
VL 91
IS 3
BP 392
EP 399
DI 10.2105/AJPH.91.3.392
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 461BL
UT WOS:000170345000010
PM 11236403
ER

PT J
AU Hertelendy, F
   Rastogi, P
   Molnar, M
   Romero, R
AF Hertelendy, F
   Rastogi, P
   Molnar, M
   Romero, R
TI Interleukin-1 beta-induced prostaglandin E-2 production in human
   myometrial cells: Role of a pertussis toxin-sensitive component
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article; Proceedings Paper
CT 46th Annual Meeting of the Society-for-Gynecologic-Investigation
CY MAR 10-13, 1999
CL ATLANTA, GA
SP Soc Gynecol Invest
DE Cyclooxygenase-2; cytokines; MAP kinase; signal transduction
ID NF-KAPPA-B; CYCLOOXYGENASE-2 EXPRESSION; SIGNALING PATHWAY; KINASE;
   ACTIVATION; INDUCTION
AB PROBLEM: The objective of this study was to evaluate the possible role of pertussis toxin (PTX)-sensitive G-protein(s) in interleukin-1 beta (IL-1) signaling in human myometrial cells (HMC).
   METHOD: Primary cultures of HMC were stimulated with human recombinant IL-1 alone or in combination with PTX. Prostaglandin (PG) E, in the medium was measured by radioimmunoassay, cyclooxygenase type 2 (Cox-2) and I kappaB by western analysis, and the activities of two members of the mitogen-activated protein kinase (MAPK) family of enzymes, ERK-2 and JNK, by the phosphorylation of appropriate substrates.
   RESULTS: IL-1 increased PGE, output during an 18-hr long incubation by 21.7-fold (n = 5 experiments). This increase was inhibited by 57% after pretreatment overnight with PTX. IL-1-induced expression of Cox-2 protein was also suppressed to a similar degree in PTX-treated HMC cultures. Degradation of the nuclear factor kappa B (NF-kappaB)-inhibiting protein (I kappaB), a critical step in IL-1 signaling to the nucleus, was significantly inhibited by PTX, as was IL-1-induced activation of ERK-2 and JNK.
   CONCLUSIONS: It is suggested that the occupied IL-1 receptor-generated signal in HMC is transmitted by multiple pathways. One is coupled to a PTX-sensitive G-protein upstream from the MAPK phosphorylation cascade. This, in turn, may interact with another signaling pathway, the activation of NF-KB, via the phosphorylation of the I kappaB kinase complex.
C1 NICHD, Perinatol Res Branch, Bethesda, MD USA.
   Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI USA.
   Semmelweis Univ, Inst Pathophysiol, H-1085 Budapest, Hungary.
   St Marys Hlth Ctr, St Louis, MO 63117 USA.
   St Louis Univ, Sch Med, Dept Obstet Gynecol & Womens Hlth, St Louis, MO USA.
RP Hertelendy, F (reprint author), St Marys Hlth Ctr, 6420 Clayton Rd, St Louis, MO 63117 USA.
EM hertelf@slu.edu
OI Molnar, Miklos/0000-0001-9231-782X
NR 16
TC 18
Z9 18
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD MAR
PY 2001
VL 45
IS 3
BP 142
EP 147
DI 10.1111/j.8755-8920.2001.450304.x
PG 6
WC Immunology; Reproductive Biology
SC Immunology; Reproductive Biology
GA 421QD
UT WOS:000168074300003
PM 11270638
ER

PT J
AU Colin, AA
   Rao, JS
   Chen, XC
   Hunter, JM
   Hanrahan, J
   Hiatt, P
   Kattan, M
   Koumbourlis, A
   Mellins, RB
   Peavy, HH
   Platzker, A
   Ting, A
   Steinbach, S
   Wohl, MEB
AF Colin, AA
   Rao, JS
   Chen, XC
   Hunter, JM
   Hanrahan, J
   Hiatt, P
   Kattan, M
   Koumbourlis, A
   Mellins, RB
   Peavy, HH
   Platzker, A
   Ting, A
   Steinbach, S
   Wohl, MEB
CA Pediat Pulmonary Cardiovascular Co
TI Forced expiratory flow in uninfected infants and children born to
   HIV-infected mothers
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
ID FUNCTIONAL RESIDUAL CAPACITY; LUNG-FUNCTION; NEWBORN-INFANTS; AIRWAY
   FUNCTION; RESPIRATORY-FUNCTION; MATERNAL SMOKING; VOLUME; LIFE;
   SPIROMETRY; PREGNANCY
AB The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV (p(2)C(2) HIV) Study is a multicenter study examining pulmonary and cardiac outcomes in offspring of HIV-infected mothers. This portion of the p(2)C(2) study tests the hypothesis that infants exposed to, but uninfected by, maternal HIV have normal maximal expiratory flow at functional residual capacity (V'max,(FRC)). We obtained 500 measurements of V'max,(FRC) by rapid thoracic compression in 285 children ages 6-30 mo in five U.S. centers. The data were compared with those from a healthy cohort of children described elsewhere. V'max,(FRC) rose with height in a linear relationship. The slope of the regression line in the exposed infants did not differ statistically from the slope in the comparison group, but the intercept was about 20% lower (p < 0.001). Height and weight were comparable in the two cohorts, and the differences between intercepts persisted after adjusting for birth weight and gestational age. However, maternal HIV infection cannot be assumed to be the cause as the cohorts may have differed in other variables, such as socioeconomic status and frequency of maternal smoking and drug use. Also, measurements varied substantially within and between our five centers, probably in part because of different racial and ethnic distributions. In summary, maternal HIV infection probably has only a modest effect, if any, on maximal expiratory flow at functional residual capacity in uninfected infants.
C1 Harvard Univ, Childrens Hosp, Sch Med, Div Pulm Med,Dept Pediat, Boston, MA 02115 USA.
   Cleveland Clin Fdn, Dept Biostat & Epidemiol, Cleveland, OH 44195 USA.
   Channing Labs, Boston, MA USA.
   Texas Childrens Hosp, Baylor Coll Med, Clin Care Ctr, Houston, TX 77030 USA.
   Mt Sinai Sch Med, Pediat Pulm & Crit Care Div, New York, NY USA.
   Columbia Univ, Presbyterian Hosp, Sch Med, Dept Pediat, New York, NY USA.
   NHLBI, Div Lung Dis, Bethesda, MD 20892 USA.
   Univ Calif Los Angeles, Univ So Calif, Childrens Hosp, Div Pediat Pulmonol, Los Angeles, CA USA.
   Boston Univ, Boston Med Ctr, Dept Pediat Pulmonol, Boston, MA USA.
   Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA.
RP Colin, AA (reprint author), Harvard Univ, Childrens Hosp, Sch Med, Div Pulm Med,Dept Pediat, 300 Longwood Ave, Boston, MA 02115 USA.
FU NCRR NIH HHS [RR-00043, RR-00188, RR-00865, RR-00533, RR-02172,
   RR-00645, RR-00071]; NHLBI NIH HHS [N01-HR-96040, N01-HR-96039,
   N01-HR-96042, N01-HR-96038, N01-HR-96037, N01-HR-96043, N01-HR-96041]
NR 38
TC 6
Z9 6
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD MAR
PY 2001
VL 163
IS 4
BP 865
EP 873
PG 9
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 421GY
UT WOS:000168057700019
PM 11282758
ER

PT J
AU Crandall, ED
   Matthay, MA
AF Crandall, ED
   Matthay, MA
TI Alveolar epithelial transport - Basic science to clinical medicine
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article; Proceedings Paper
CT Workshop of the
   Division-of-Lung-Diseases-National-Heart-Lung-and-Blood-Institute
CY AUG 31-SEP 01, 1999
CL BETHESDA, MARYLAND
SP Div Lung Dis Natl Lung & Blood Inst
ID LUNG LIQUID CLEARANCE; RESPIRATORY-DISTRESS-SYNDROME; HYDROSTATIC
   PULMONARY-EDEMA; SURFACE FLUORESCENCE METHOD; AQUAPORIN WATER CHANNELS;
   ACTIVE SODIUM-TRANSPORT; ALPHA-SUBUNIT GENE; FLUID CLEARANCE; II CELLS;
   RAT LUNG
C1 Univ So Calif, Dept Med, Los Angeles, CA USA.
   Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA.
RP Crandall, ED (reprint author), NHLBI, Div Lung Dis, Rockledge Ctr 6701, Suite 10018,MSC 7952, Bethesda, MD 20892 USA.
NR 169
TC 81
Z9 89
U1 0
U2 1
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD MAR
PY 2001
VL 163
IS 4
BP 1021
EP 1029
PG 9
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 421GY
UT WOS:000168057700044
PM 11282783
ER

PT J
AU Darwish, MA
   Faris, R
   Darwish, N
   Shouman, A
   Gadallah, M
   El-Sharkawy, MS
   Edelman, R
   Grumbach, K
   Rao, MR
   Clemens, JD
AF Darwish, MA
   Faris, R
   Darwish, N
   Shouman, A
   Gadallah, M
   El-Sharkawy, MS
   Edelman, R
   Grumbach, K
   Rao, MR
   Clemens, JD
TI Hepatitis C and cirrhotic liver disease in the Nile delta of Egypt: A
   community-based study
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HIGH SEROPREVALENCE; SCHISTOSOMA-MANSONI; INTERFERON-ALPHA; VIRUS
   GENOTYPE-4; BLOOD-DONORS; INFECTION; PREVALENCE; RISK
AB Residents of Egypt's Nile river delta have among the world's highest seroprevalence of hepatitis C virus (HCV) infection. To assess the impact of HCV on chronic liver disease, we studied the association between HCV, other hepatitis viruses, and cirrhotic liver disease in a cross-sectional, community-based survey of 801 persons aged greater than or equal to 10 years living in a semi-urban, Nile delta village. Residents were systematically sampled using questionnaires, physical examination, abdominal ultrasonography and serologically for antibodies to HCV (confirmed by a third-generation immunoblot assay) and to hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis E virus (HEV). The seroprevalence of HCV increased with age from 19% in persons 10-19 years old to about 60% in persons 30 years and older. Although no practices that might facilitate HCV transmission were discovered, the seroprevalence of HCV was significantly associated with remote (> 1 year) histories of schistosomiasis. Sonographic evidence of cirrhosis was present in 3% (95% CI: 1%, 4%) of the population (0.7% of persons under 30 years of age and in 5% of older persons), and was significantly associated with HCV seroreactivity. Our findings are consistent with the hypothesis that past mass parenteral chemotherapy campaigns for schistosomiasis facilitated HCV transmission, and that HCV may be a major cause of the high prevalence of liver cirrhosis in this Nile village.
C1 WHO, Collaborating Ctr Clin Evaluat Vaccines Dev Count, Bethesda, MD USA.
   NICHHD, Bethesda, MD 20892 USA.
   Univ Maryland, Sch Med, Div Geog Med, Baltimore, MD USA.
   Univ Maryland, Sch Med, Dept Radiol, Baltimore, MD 21201 USA.
   Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
   Theodor Bilharz Res Inst, Giza, Egypt.
   Ain Shams Univ, Sch Med, Cairo, Egypt.
RP Rao, MR (reprint author), NICHD, Epidemiol Branch, Div Prevent Res, NIH, 6100 Execut Blvd,Room 7B03, Bethesda, MD 20892 USA.
RI Grumbach, Kevin/L-9222-2016
NR 29
TC 43
Z9 45
U1 0
U2 0
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAR-APR
PY 2001
VL 64
IS 3-4
BP 147
EP 153
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 445UA
UT WOS:000169475900007
PM 11442209
ER

PT J
AU Diallo, TO
   Spiegel, A
   Diouf, A
   Perraut, R
   Kaslow, DC
   Garraud, O
AF Diallo, TO
   Spiegel, A
   Diouf, A
   Perraut, R
   Kaslow, DC
   Garraud, O
TI Short report: IgGI/IgG3 antibody responses to various analogs of
   recombinant yPfMSPl(19) - A study in immune adults living in areas of
   Plasmodium falciparum transmission
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID PROTECTIVE IMMUNITY; HOLOENDEMIC AREA; STAGE ANTIGENS; IN-VITRO;
   MALARIA; INDIVIDUALS; INFECTION; SENEGAL; DIELMO
AB To further characterize protective-type (IgG1/IgG3) antibody responses to Plasmodium falciparum blood stage in putatively immune individuals' plasma, we have tested for various analogs of the 19 kDa C-terminus of the MSP1 antigen obtained as secreted recombinant proteins from Saccharomyces cerevisiae. One of four proteins was then identified on the basis of consistent IgG3, along with less variable IgG1 recognition. This protein has thus been selected for further functional assays of IgG1/IgG3 antibodies.
C1 NIAID, Mol Vaccine Sect, NIH, Bethesda, MD 20892 USA.
   Inst Pasteur, Epidemiol Unit, Dakar, Senegal.
   Inst Pasteur, Unite Immunol, Dakar, Senegal.
RP Garraud, O (reprint author), Fac Med, GIMAP, 15 Rue Ambroise Pare, F-42023 St Etienne, France.
NR 14
TC 15
Z9 15
U1 0
U2 1
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAR-APR
PY 2001
VL 64
IS 3-4
BP 204
EP 206
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 445UA
UT WOS:000169475900016
PM 11442218
ER

PT J
AU Martin, SE
AF Martin, SE
TI The links between alcohol, crime and the criminal justice system:
   Explanations, evidence and interventions
SO AMERICAN JOURNAL ON ADDICTIONS
LA English
DT Article; Proceedings Paper
CT 153rd Annual Meeting of the American-Psychiatric-Association
CY MAY 13-18, 2000
CL CHICAGO, ILLINOIS
SP Amer Psychiat Assoc
ID EMERGENCY ROOM; INTOXICATED AGGRESSION; ASSAULTIVE VIOLENCE; DRINKING;
   AVAILABILITY; RISK; ISSUES; BARS; SELF; METAANALYSIS
AB Many studies indicate that alcohol abuse and dependence are closely linked with the criminal justice system (CJS). Alcohol was consumed prior to about half of all homicides and assaults, and nearly 40 percent of state prisoners report committing their current offense under the influence of alcohol. Alcohol abuse cost approximately $13 billion in 1992 non-health related costs. This article seeks to address this burden on the CJS and society. It presents a conceptual framework for explaining the alcohol-crime nexus, reviews empirical evidence of the complex associations between alcohol consumption and crime, and links these with promising intervention strategies to reduce alcohol-related crime.
C1 NIAAA, Bethesda, MD 20892 USA.
RP Martin, SE (reprint author), NIAAA, 6000 Execut Blvd, Bethesda, MD 20892 USA.
NR 119
TC 29
Z9 29
U1 2
U2 6
PU BRUNNER-ROUTLEDGE
PI PHILADELPHIA
PA 325 CHESTNUT ST, 8TH FL, PHILADELPHIA, PA 19106 USA
SN 1055-0496
J9 AM J ADDICTION
JI Am. J. Addict.
PD SPR
PY 2001
VL 10
IS 2
BP 136
EP 158
DI 10.1080/105504901750227796
PG 23
WC Substance Abuse
SC Substance Abuse
GA 443XD
UT WOS:000169367400004
PM 11444156
ER

PT J
AU Gerald, MS
AF Gerald, MS
TI Primate colour predicts social status and aggressive outcome
SO ANIMAL BEHAVIOUR
LA English
DT Article
ID MONKEYS CERCOPITHECUS-AETHIOPS; MALE VERVET MONKEYS; DOMINANCE
   ACQUISITION; PLUMAGE VARIABILITY; EVOLUTION; SELECTION; BEHAVIOR;
   SABAEUS; SIGNALS; COST
AB Colourful signals in insects, fish, amphibians, lizards and birds have attracted considerable attention among evolutionary biologists. While primates display the most conspicuous secondary sexual coloration in mammals, little is known about its function. In several types of organisms, variation in colour predicts differences in social status. For this study, I experimentally investigated the relationship between scrotal colour and social status in adult vervet monkeys Cercopithecus aethiops sabaeus, by analysing the social interactions between pairs of unfamiliar males matched for size, but differing in scrotal colour. Differences in scrotal colour predicted eventual social status, as males with a dark scrotum dominated those with a pale scrotum. Experimental modification of scrotal colour failed to confirm that scrotal colour alone signalled social status, but supported the finding that males with scrota of similar colour were more antagonistic towards each other than males differing in colour. These results represent the first experimental evidence for a relationship between colour and social status in primates. (C) 2001 The Association for the Study of Animal Behaviour.
C1 Univ Calif Los Angeles, Dept Anthropol, Los Angeles, CA 90024 USA.
RP Gerald, MS (reprint author), NIH, Anim Ctr, POB 529,Bldg 112,Room 213, Poolesville, MD 20837 USA.
NR 45
TC 65
Z9 65
U1 9
U2 47
PU ACADEMIC PRESS LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0003-3472
J9 ANIM BEHAV
JI Anim. Behav.
PD MAR
PY 2001
VL 61
BP 559
EP 566
DI 10.1006/anbe.2000.1648
PN 3
PG 8
WC Behavioral Sciences; Zoology
SC Behavioral Sciences; Zoology
GA 420DZ
UT WOS:000167990100005
ER

PT J
AU Cheng, TL
   Wright, JL
   Fields, CB
   Brenner, RA
   O'Donnell, R
   Schwarz, D
   Scheidt, PC
AF Cheng, TL
   Wright, JL
   Fields, CB
   Brenner, RA
   O'Donnell, R
   Schwarz, D
   Scheidt, PC
CA DC Child Adolescent Injury Res Ne
TI Violent injuries among adolescents: Declining morbidity and mortality in
   an urban population
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Article; Proceedings Paper
CT 32nd Annual Meeting of the Society-for-Adolescent-Medicine
CY MAR, 2000
CL CRYSTAL CITY, VIRGINIA
SP Soc Adolescent Med
ID HIGH-SCHOOL-STUDENTS; BLACK-ADOLESCENTS; UNITED-STATES; SUBSTANCE USE;
   RISK-FACTORS; HEALTH-RISK; BEHAVIORS; RATES; YOUTH; EPIDEMIOLOGY
AB Study objective: Adolescent homicide rates are decreasing nationally for unclear reasons. We explore changes in intentional injury morbidity and mortality within the context of other injuries and specific causes.
   Methods: We performed surveillance of hospital, medical examiner, and vital records for nonfatal injury among adolescents age 10 to 19 years living in the District of Columbia from June 15, 1996, to June 15, 1998, and fatal injury from 1989 to 1998.
   Results: Over the 2-year study period, 15,190 adolescents were seen for injury, resulting in an event-based rate of 148 injuries per 1,000 adolescents per year; 7% required hospitalization, and 0.8% died. Interpersonal intentional injuries accounted for 25% of all injuries, 45% of hospitalizations, and 85% of injury deaths. Assault morbidity decreased with no change noted for unintentional and self-inflicted injury. Firearm injuries, stabs, and assaults with other objects showed the largest decrease, with no decrease in unarmed assaults. Injury mortality peaked in 1993 and has declined since. Firearms caused 72% to 90% of all injury deaths from 1989 to 1998, most the result of homicide.
   Conclusion: There has been a decline in intentional injury rates over the study periods related to decreased weapon injury; data suggest a change in the lethality of fighting methods but no change in unarmed fighting behavior.
C1 Childrens Natl Med Ctr, Dept Gen Pediat & Adolescent Med, Washington, DC 20010 USA.
   George Washington Univ, Sch Med, Childrens Res Inst, Washington, DC USA.
   George Washington Univ, Sch Publ Hlth, Washington, DC USA.
   Childrens Natl Med Ctr, Dept Emergency Med, Washington, DC 20010 USA.
   NICHHD, Bethesda, MD 20892 USA.
   Childrens Hosp Philadelphia, Craig Dalsimer Div Adolescent Med, Philadelphia, PA 19104 USA.
RP Cheng, TL (reprint author), Childrens Natl Med Ctr, Dept Gen Pediat & Adolescent Med, 111 Michigan Ave NW, Washington, DC 20010 USA.
FU PHS HHS [R49/CCR311657-01]
NR 46
TC 22
Z9 22
U1 0
U2 0
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD MAR
PY 2001
VL 37
IS 3
BP 292
EP 300
DI 10.1067/mem.2001.111763
PG 9
WC Emergency Medicine
SC Emergency Medicine
GA 408BK
UT WOS:000167306500007
PM 11223766
ER

PT J
AU Burt, CW
   Overpeck, MD
AF Burt, CW
   Overpeck, MD
TI Emergency visits for sports-related injuries
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Article
ID US CHILDREN; ADOLESCENTS
AB Study objective: We sought to estimate the effect and magnitude of patients with sports-related injuries presenting to hospital emergency departments in the United States and to examine differences in patient acid visit characteristics between sports- and nonsports-related injuries.
   Methods: Data from the 1997 and 1998 National Hospital Ambulatory Medical Care Survey, a national probabilistic sample of 496 US hospital EDs, were combined to examine emergency visits for sports-related injuries. Data from 16,997 sample ED encounter records for injuries that included narrative cause of injury text were analyzed. Narrative text entries were coded to 1 of 84 sport and recreational activity codes. Sample weights were applied to provide annual national estimates. Estimates of sports-related injury visits were based on 1.775 records with an assigned sports-related activity code.
   Results: There were an average annual estimated 2.6 million emergency visits for sports-related injuries by persons between the ages of 5 and 24 years. They accounted for over 68% of the total 3.7 million sport injuries presented to the ED by persons of all ages. As a proportion of all kinds of injuries presenting to the ED, sports-related injuries accounted for more than one fifth of the visits by persons 5 to 24 years old. The use rate was 33.9 ED visits per 1,000 persons in this age group (95% confidence interval 30.3 to 37.5). The sports-related injury visit rate for male patients was more than double the rate for female patients (48.2 versus 19.2 per 1,000 persons between 5 and 24 years of age). Visits from sports-related activities for this age group were more frequent for basketball and cycling compared with other categories (eg, baseball, skateboarding, gymnastics). Compared with nonsports-related injuries for this age group, sports-related injuries were more likely to be to the brain or skull and upper and lower extremities. Patients with sports-related injuries were more likely to have a diagnosis of fracture and sprain or strain and less likely to have an open wound. They were also more likely to have diagnostic and therapeutic services provided, especially orthopedic care.
   Conclusion: Sports-related activities by school-age children and young adults produce a significant amount of emergency medical use in the United States. The ED is an appropriate venue to target injury prevention counseling.
C1 Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
   NICHHD, NIH, Bethesda, MD 20892 USA.
RP Burt, CW (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Room 952,6525 Belcrest Rd, Hyattsville, MD 20782 USA.
NR 18
TC 111
Z9 112
U1 1
U2 8
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD MAR
PY 2001
VL 37
IS 3
BP 301
EP 308
DI 10.1067/mem.2001.111707
PG 8
WC Emergency Medicine
SC Emergency Medicine
GA 408BK
UT WOS:000167306500008
PM 11223767
ER

PT J
AU Kallioniemi, OP
AF Kallioniemi, OP
TI Biochip technologies in cancer research
SO ANNALS OF MEDICINE
LA English
DT Article
DE biochip; bioinformatics; genomics; microarray; proteomics;
   single-nucleotide polymorphism
ID LARGE-SCALE IDENTIFICATION; GENE-EXPRESSION; MOLECULAR CLASSIFICATION;
   DNA; MICROARRAYS
AB Development of high-throughput 'biochip' technologies has dramatically enhanced our ability to study biology and explore the molecular basis of disease. Biochips enable massively parallel molecular analyses to be carried out in a miniaturized format with a very high throughput. This review will highlight applications of the various biochip technologies in cancer research, including analysis of 1) disease predisposition by using single-nucleotide polymorphism (SNP) microarrays, 2) global gene expression patterns by cDNA microarrays, 3) concentrations, functional activities or interactions of proteins with proteomic biochips, and 4) cell types or tissues as well as clinical endpoints associated with molecular targets by using tissue microarrays, One can predict that individual cancer risks can, in the future, be estimated accurately by a microarray profile of multiple SNPs in critical genes. Diagnostics of cancer will be facilitated by biochip readout of activity levels of thousands of genes and proteins. Biochip diagnostics coupled with informatics solutions will form the basis of individualized treatment decisions for cancer patients.
C1 NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
RP Kallioniemi, OP (reprint author), NHGRI, Canc Genet Branch, NIH, 49 Convent Dr, Bethesda, MD 20892 USA.
RI Kallioniemi, Olli/H-5111-2011; Kallioniemi, Olli/H-4738-2012
OI Kallioniemi, Olli/0000-0002-3231-0332; Kallioniemi,
   Olli/0000-0002-3231-0332
NR 14
TC 53
Z9 62
U1 1
U2 7
PU ROYAL SOC MEDICINE PRESS LTD
PI LONDON
PA 1 WIMPOLE STREET, LONDON W1M 8AE, ENGLAND
SN 0785-3890
J9 ANN MED
JI Ann. Med.
PD MAR
PY 2001
VL 33
IS 2
BP 142
EP 147
DI 10.3109/07853890109002069
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 421HU
UT WOS:000168059600008
PM 11327117
ER

PT J
AU Ibrahim, S
   Peggins, J
   Knapton, A
   Licht, T
   Aszalos, A
AF Ibrahim, S
   Peggins, J
   Knapton, A
   Licht, T
   Aszalos, A
TI Influence of beta-adrenergic antagonists, H1-receptor blockers,
   analgesics, diuretics, and quinolone antibiotics on the cellular
   accumulation of the anticancer drug, daunorubicin: P-glycoprotein
   modulation
SO ANTICANCER RESEARCH
LA English
DT Article
DE drug classes; multidrug resistance; P-glycoprotein; daunorubicin
ID BLOOD-BRAIN-BARRIER; MULTIDRUG-RESISTANCE; CLINICAL-TRIALS;
   PHARMACOKINETICS; EXPRESSION; BIOAVAILABILITY; SINGLE; FORMULATIONS;
   CELLS; GENE
AB Background: Treatment of patients with several drugs simultaneously may result in modulation of the naturally expressed P-glycoprotein (Pgp) at different tissues. With this possibility in mind, we have assessed the ability of different classes of drugs to modulate Pgp function in vitro. Modulation of the Pgp function was studied at in vitro drug concentrations comparable to therapeutic blood levels of the drugs. Materials and Methods: Human blood brain barrier endothelial cells and human colon adenocarcinoma cells were transduced or transfected with the multidrug resistance gene (MDR1) to express Pgp. The uptake of fluorescent substrates of Pgp, Rhodamine 123 and daunorubicin, into these cells and NIH3T3/MDR1 and MDCK/MDR1 cells was measured by flow cytometry and in monolayers in the presence and absence of the different drugs. Results: From the tested six H-1-receptor blockers, seven beta-adrenergic antagonists, four analgesics, ten diuretics and five quinolons, five drugs inhibited Pgp at therapeutic blood levels and two at somewhat higher concentrations. Significant synergism for blocking Pgp could be demonstrated for several drugs. Conclusion: We conclude that administration of several drugs which modulate the function of Pgp to patients may adversely affect the natural function of this efflux pump and malt cause drug-drug interactions induced side effects.
C1 US FDA, Off Clin Pharmacol & Biopharmaceut, Rockville, MD 20857 USA.
   US FDA, Ctr Vet Med, Rockville, MD 20857 USA.
   US FDA, Div Appl Pharmacol Res, Rockville, MD 20857 USA.
   NCI, NIH, Bethesda, MD 20892 USA.
RP Ibrahim, S (reprint author), US FDA, Off Clin Pharmacol & Biopharmaceut, HFD 860,5600 Fishers Lane, Rockville, MD 20857 USA.
NR 48
TC 13
Z9 14
U1 0
U2 3
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDNTIOU-KALAMOU RD KAPANDRITI, POB 22,
   ATHENS 19014, GREECE
SN 0250-7005
J9 ANTICANCER RES
JI Anticancer Res.
PD MAR-APR
PY 2001
VL 21
IS 2A
BP 847
EP 856
PG 10
WC Oncology
SC Oncology
GA 437UQ
UT WOS:000169012300004
PM 11396174
ER

PT J
AU Elmore, E
   Stringer, DE
   Steele, VE
   Gerner, EW
   Redpath, JL
AF Elmore, E
   Stringer, DE
   Steele, VE
   Gerner, EW
   Redpath, JL
TI Chemoprevention by difluoromethylornithine: Correlation of an in vitro
   human cell assay with human clinical data for biomarker modulation
SO ANTICANCER RESEARCH
LA English
DT Article
DE cancer prevention efficacy; in vitro/in vivo correlation; human
   cells/tissues; difluoromethylornithine; poly-amines; growth inhibition;
   involucrin expression
ID ORNITHINE DECARBOXYLASE ACTIVITY; ALPHA-DIFLUOROMETHYLORNITHINE; MARKER;
   TRIAL
AB The efficacy of difluoromethylornithine (DFMO) as a chemopreventive agent has been tested in vitro using a human epidermal cell (HEC) assay with growth inhibition and involucrin induction as endpoints. Suppression of polyamine content is currently being utilized as a biomarker in clinical trials for the chemopreventive efficacy of DFMO against colon cancer formation. We have now examined the effects of DFMO on suppression of polyamine content in the HEC assay. The findings indicate 1) the % change in spermidine to spermine ratio and the depletion of putrescine shaw excellent correlation with chemopreventive e efficacy in vitro; 2) the effective concentrations in vitro overlap the plasma concentrations in the clinical trial. These observations serve as further validation of the usefulness of the HEC assay as a screen for chemopreventive efficacy.
C1 Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA 92697 USA.
   Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA.
   Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85724 USA.
   Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA.
   NCI, Chemoprevent Agent Dev Res Grp, DCP, NIH, Bethesda, MD 20892 USA.
RP Redpath, JL (reprint author), Univ Calif Irvine, Dept Radiat Oncol, B140, Irvine, CA 92697 USA.
FU NCI NIH HHS [CA-72008, N01-CN-65115]
NR 10
TC 7
Z9 7
U1 0
U2 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDNTIOU-KALAMOU RD KAPANDRITI, POB 22,
   ATHENS 19014, GREECE
SN 0250-7005
J9 ANTICANCER RES
JI Anticancer Res.
PD MAR-APR
PY 2001
VL 21
IS 2A
BP 1163
EP 1165
PG 3
WC Oncology
SC Oncology
GA 437UQ
UT WOS:000169012300049
PM 11396157
ER

PT J
AU Ratnasinghe, D
   Tangrea, JA
   Stewart, C
   Bhat, NK
   Virtamo, J
   Albanes, D
   Taylor, PR
AF Ratnasinghe, D
   Tangrea, JA
   Stewart, C
   Bhat, NK
   Virtamo, J
   Albanes, D
   Taylor, PR
TI Influence of antioxidants and the CYP1A1 isoleucine to valine
   polymorphism on the Smoking Lung Cancer Association
SO ANTICANCER RESEARCH
LA English
DT Article
DE ATE study; cancer polymorphism; CYP1A1
ID BETA-CAROTENE; ALPHA-TOCOPHEROL; SUSCEPTIBILITY; GLUTATHIONE;
   PREVENTION; RISK; GENE
AB To evaluate the association between CYP1A1 genotype and king cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking - lung cancer relationship we conducted a case-control study nested within a large cancel prevention trial cohort. Controls (n=324) were matched to cases (n=282) on age (+/- 5 years), intervention group and study clinic in a 1:1 ratio using incidence density sampling. Genotype was determined by a PCR-based method and logistic regression was used to calculate relative risk estimates. Overall, we found no association between CYP1A1 genotype and lung cancer risk. CYP1A1 genotype did not modify the effect of smoking on lung cancel risk. However; in an examination of subgroups defined by randomized intervention assignment our findings suggest that alpha-tocopherol supplementation may reduce the risk of lung cancer associated with cumulative smoking exposure regardless of CYP1A1 genotype with the greatest effect seen among those with the variant CYP1A1 allele.
C1 NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, Bethesda, MD 20892 USA.
   FCRDC, SAIC, Frederick, MD USA.
   Natl Publ Hlth Inst, Helsinki, Finland.
RP Ratnasinghe, D (reprint author), NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, Suite 321,6006 Execut Blvd,MSC 7058, Bethesda, MD 20892 USA.
RI Albanes, Demetrius/B-9749-2015
NR 14
TC 6
Z9 6
U1 0
U2 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDNTIOU-KALAMOU RD KAPANDRITI, POB 22,
   ATHENS 19014, GREECE
SN 0250-7005
J9 ANTICANCER RES
JI Anticancer Res.
PD MAR-APR
PY 2001
VL 21
IS 2B
BP 1295
EP 1299
PG 5
WC Oncology
SC Oncology
GA 437UR
UT WOS:000169012400009
PM 11396202
ER

PT J
AU Mori, T
   Boyd, MR
AF Mori, T
   Boyd, MR
TI Cyanovirin-N, a potent human immunodeficiency virus-inactivating
   protein, blocks both CD4-dependent and CD4-independent binding of
   soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of
   sgp120 to cell-associated CXCR4, and dissociates bound sgp120 from
   target cells
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID HUMAN MONOCLONAL-ANTIBODIES; CHEMOKINE RECEPTOR; ENVELOPE GLYCOPROTEIN;
   FAB FRAGMENTS; TYPE-1; HIV; CD4; NEUTRALIZATION; CORECEPTOR; SITE
AB Cyanovirin-N (CV-N), an 11-kDa protein originally isolated from the cyanobacterium Nostoc ellipsosporum, potently inactivates diverse strains of human immunodeficiency virus type 1 (HIV-1), HIV-2, simian immunodeficiency virus, and feline immunodeficiency virus. It has been well established that the HIV surface envelope glycoprotein gp120 is a molecular target of CV-N, We recently reported that CV-N impaired the binding of virion-associated gp120 to cell-associated CD4 and that CV-N preferentially inhibited binding of the glycosylation-dependent neutralizing monoclonal antibody 2G12 to gp120, However, CV-N did not interfere with the interactions of soluble CD4 (sCD4) with either soluble gp120 (sgp120) or virion-associated gp120. In the present study, we have evaluated the effects of CV-N on the binding of sgp120 to cell-associated CD4 to clarify the experimental basis of the previous binding results, and we further address the detailed mechanism of action of CV-N, Here we present evidence that (i) CV-N impairs both CD4-dependent and CD4-independent binding of sgp120 to the target cells, (ii) CV-N blocks the sCD4-induced binding of sgp120 with cell-associated coreceptor CXCR4, and (iii) CV-N dissociates bound sgp120 from target cells. The results illustrate that the measured effects of CV-N on gp120-CD4 binding interactions depend upon the type of CD4 (soluble or cell associated), but not upon the type of gp120 (soluble or virion associated), employed in the experimental protocol. In addition, this study reinforces that CV-N acts uniquely to prevent essential interactions between the envelope glycoprotein and target cell receptors and further supports the potential broad utility of CV-N as a microbicide to prevent the transmission of HIV and AIDS.
C1 NCI, Lab Nat Prod, Div Basic Sci, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
RP Boyd, MR (reprint author), NCI, Lab Nat Prod, Div Basic Sci, Frederick Canc Res & Dev Ctr, Bldg 1052,Rm 121, Frederick, MD 21702 USA.
NR 38
TC 66
Z9 72
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2001
VL 45
IS 3
BP 664
EP 672
DI 10.1128/AAC.45.3.664-672.2001
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 405AJ
UT WOS:000167134800003
PM 11181340
ER

PT J
AU Ma, L
   Kovacs, JA
AF Ma, L
   Kovacs, JA
TI Rapid detection of mutations in the human-derived Pneumocystis carinii
   dihydropteroate synthase gene associated with sulfa resistance
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID F SP. HOMINIS; AIDS PATIENTS; REGIONS; SEQUENCE; DNA; POLYMORPHISMS;
   PNEUMONIA
AB Recent studies have shown that point mutations in the dihydropteroate synthase (DHPS) gene of human-derived Pneumocystis carinii are related to exposure to sulfa drugs and possibly represent the emergence of sulfa resistance. We developed a simple single-strand conformation polymorphism (SSCP) method to permit rapid detection of these mutations. With plasmid constructs, SSCP was able to detect as little as 10% of a minority population. The SSCP assay was compared to direct sequencing for typing the DHPS gene by examining 37 clinical isolates with known DHPS sequences and 41 clinical isolates with unknown DHPS sequences. The typing results were consistent between these two methods for all isolates except 11 in which mutations were detected by SSCP but not by direct sequencing. Sequencing of individual clones after subcloning confirmed the presence of mutations in a minority population as determined by SSCP. SSCP is a very simple and sensitive method for rapid identification of P. camii DHPS mutations.
C1 NIH, Dept Crit Care Med, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA.
RP Kovacs, JA (reprint author), NIH, Dept Crit Care Med, Warren Grant Magnuson Clin Ctr, Bldg 10,Room 7D43,10 Ctr Dr MSC 1662, Bethesda, MD 20892 USA.
NR 18
TC 15
Z9 16
U1 2
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2001
VL 45
IS 3
BP 776
EP 780
DI 10.1128/AAC.45.3.776-780.2001
PG 5
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 405AJ
UT WOS:000167134800022
PM 11181359
ER

PT J
AU Petraitiene, R
   Petraitis, V
   Groll, AH
   Sein, T
   Piscitelli, S
   Candelario, M
   Field-Ridley, A
   Avila, N
   Bacher, J
   Walsh, TJ
AF Petraitiene, R
   Petraitis, V
   Groll, AH
   Sein, T
   Piscitelli, S
   Candelario, M
   Field-Ridley, A
   Avila, N
   Bacher, J
   Walsh, TJ
TI Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in
   treatment and prevention of experimental invasive pulmonary
   aspergillosis: Correlation with galactomannan antigenemia
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; IN-VITRO ACTIVITIES; CT HALO SIGN;
   AMPHOTERICIN-B; CRYPTOCOCCUS-NEOFORMANS; NEUTROPENIC PATIENTS; SERUM
   GALACTOMANNAN; TRIAZOLE SCH-56592; FILAMENTOUS FUNGI; CANDIDA-ALBICANS
AB The antifungal efficacy, safety, and pharmacokinetics of posaconazole (SCH 56592) (POC) were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Antifungal therapy consisted of POC at 2, 6, and 20 mg/kg of body weight per os; itraconazole (ITC) at 2, 6, and 20 mg/kg per os; or amphotericin B (AMB) at 1 mg/kg intravenously. Rabbits treated with POC showed a significant improvement in survival and significant reductions in pulmonary infarct scores, total lung weights, numbers of pulmonary CFU per gram, numbers of computerized-tomography-monitored pulmonary lesions, and levels of galactomannan antigenemia, AMB and POC had comparable therapeutic efficacies by all parameters. By comparison, animals treated with ITC had no significant changes in outcome variables in comparison to those of untreated controls (UC), Rabbits receiving prophylactic POC at all dosages showed a significant reduction in infarct scores, total lung weights, and organism clearance from lung tissue in comparison to results for UC (P < 0.01). There was dosage-dependent microbiological clearance of A. fumigatus from lung tissue in response to POC, Serum creatinine levels were greater (P < 0.01) in AMB-treated animals than in UC and POC- or ITC-treated rabbits, There was no elevation of serum hepatic transaminase levels in POC- or ITC-treated rabbits. The pharmacokinetics of POC and ITC in plasma demonstrated dose dependency after multiple dosing. The 2-, 6-, and 20-mg/kg dosages of POC maintained plasma drug levels above the MICs for the entire 24-h dosing interval. In summary, POC at greater than or equal to6 mg/kg/day per os generated sustained concentrations in plasma of greater than or equal to1 mug/ml that were as effective in the treatment and prevention of invasive pulmonary aspergillosis as AMB at 1 mg/kg/day and more effective than cyclodextrin ITC at greater than or equal to6 mg/kg/day per os in persistently neutropenic rabbits.
C1 NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA.
   NIH, Pharmacokinet Res Lab, Dept Pharm, Bethesda, MD 20892 USA.
   NIH, Dept Radiol, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA.
   NIH, Vet Resources Program, Off Res Serv, Bethesda, MD 20892 USA.
RP Walsh, TJ (reprint author), NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bldg 10,Rm 13N240,Ctr Dr, Bethesda, MD 20892 USA.
NR 51
TC 119
Z9 123
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2001
VL 45
IS 3
BP 857
EP 869
DI 10.1128/AAC.45.3.857-869.2001
PG 13
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 405AJ
UT WOS:000167134800035
PM 11181372
ER

PT J
AU de Murphy, CA
   Ferro-Flores, G
   Pedraza-Lopez, M
   Melendez-Alafort, L
   Croft, BY
   Ramirez, FD
   Padilla, J
AF de Murphy, CA
   Ferro-Flores, G
   Pedraza-Lopez, M
   Melendez-Alafort, L
   Croft, BY
   Ramirez, FD
   Padilla, J
TI Labelling of Re-ABP with Re-188 for bone pain palliation
SO APPLIED RADIATION AND ISOTOPES
LA English
DT Article
DE Re-188-ABP; Re-188-alendronate; Re-188 labelled bisphosphonates
ID DIPHOSPHONATE; ALENDRONATE; FRAGMENTS; COMPLEXES
AB Etidronate and medronate have been labelled with technetium-99m (Tc-99m-HEDP, Tc-99m-MDP) for bone scanning and, with rhenium-188 (Re-188-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-Re-188. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [Re-188]Re-ABP and similarities with Tc-99m-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation. (C) 2001 Elsevier Science Ltd. All rights reserved.
C1 Inst Nacl Nutr Salvador Zubiran, Dept Nucl Med, Mexico City 14000, DF, Mexico.
   Inst Nacl Invest Nucl, Dept Mat Radiact, Salazar 52045, Mexico, Mexico.
   Inst Nacl Invest Nucl, Dept Quim, Salazar 52045, Mexico, Mexico.
   NCI, NIH, Bethesda, MD 20892 USA.
   Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Mexico City 09820, DF, Mexico.
RP de Murphy, CA (reprint author), Inst Nacl Nutr Salvador Zubiran, Dept Nucl Med, Vasco Quiroga 15,Delegac Tialpan, Mexico City 14000, DF, Mexico.
RI Padilla, Juan/B-5265-2008; Croft, Barbara/D-1248-2013; Melendez-Alafort
   , Laura /B-8918-2013; 
OI Padilla, Juan/0000-0002-3953-9228; Croft, Barbara/0000-0003-2544-150X;
   Melendez-Alafort , Laura /0000-0003-0701-3616; FERRO-FLORES,
   GUILLERMINA/0000-0003-0296-7605
NR 28
TC 10
Z9 10
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0969-8043
J9 APPL RADIAT ISOTOPES
JI Appl. Radiat. Isot.
PD MAR
PY 2001
VL 54
IS 3
BP 435
EP 442
PG 8
WC Chemistry, Inorganic & Nuclear; Nuclear Science & Technology; Radiology,
   Nuclear Medicine & Medical Imaging
SC Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 396QU
UT WOS:000166648700011
ER

PT J
AU Schaeberle, MD
   Tuschel, DD
   Treado, PJ
AF Schaeberle, MD
   Tuschel, DD
   Treado, PJ
TI Raman chemical imaging of microcrystallinity in silicon semiconductor
   devices
SO APPLIED SPECTROSCOPY
LA English
DT Article
DE silicon semiconductors; ion implantation; polysilicon; chemical imaging;
   Raman imaging; Raman spectroscopy; volumetric imaging; numerical
   confocal microscopy
ID TUNABLE FILTER; SPECTROSCOPY; MICROSCOPY; STRESS; SI; SCATTERING; GAAS;
   ARCHITECTURE; MORPHOLOGY; EXCITATION
AB Silicon integrated circuits are fabricated by the creation of complex layered structures. The complexity of these structures provides many opportunities fur impurities, improperly annealed dopants, and stress effects to cause device contamination and failure. Nondestructive metrology techniques that rapidly and noninvasively screen for defects and relate silicon device structure to device performance are of value. We describe the first use of a liquid crystal tunable filter (LCTF) Raman chemical imaging microscope to assess the crystallinity of silicon semiconductor integrated circuits in a rapid and nondestructive manner without the need for sample preparation. The instrument has demonstrated lateral spatial resolving power of better than 250 nm and is equipped with a tunable imaging spectrometer having a spectral bandpass of 7.6 cm(-1). The instrument rapidly produces high-definition Raman images where each image pixel contains a high-quality Raman spectrum. When combined with powerful processing strategies, the Raman chemical imaging system has demonstrated spectral resolving power of 0.03 cm(-1) in a test silicon semiconductor wafer fabricated hy using ion implantation. In addition, we have applied Raman chemical imaging for volumetric Raman imaging by analyzing the surface distribution of polycrystalline thin film structures. The approaches described here for the first time are generally applicable to the nondestructive metrology of silicon and compound semiconductor devices.
C1 ChemIcon Inc, Pittsburgh, PA 15208 USA.
   NIH, Bethesda, MD 20892 USA.
   Eastman Kodak Co, Imaging Res & Adv Dev, Rochester, NY 14650 USA.
RP Treado, PJ (reprint author), ChemIcon Inc, 7301 Penn Ave, Pittsburgh, PA 15208 USA.
NR 33
TC 8
Z9 8
U1 0
U2 7
PU SOC APPLIED SPECTROSCOPY
PI FREDERICK
PA 201B BROADWAY ST, FREDERICK, MD 21701 USA
SN 0003-7028
J9 APPL SPECTROSC
JI Appl. Spectrosc.
PD MAR
PY 2001
VL 55
IS 3
BP 257
EP 266
DI 10.1366/0003702011951867
PG 10
WC Instruments & Instrumentation; Spectroscopy
SC Instruments & Instrumentation; Spectroscopy
GA 417ZF
UT WOS:000167864800004
ER

PT J
AU Castellanos, FX
   Giedd, JN
   Berquin, PC
   Walter, JM
   Sharp, W
   Tran, T
   Vaituzis, AC
   Blumenthal, JD
   Nelson, J
   Bastain, TM
   Zijdenbos, A
   Evans, AC
   Rapoport, JL
AF Castellanos, FX
   Giedd, JN
   Berquin, PC
   Walter, JM
   Sharp, W
   Tran, T
   Vaituzis, AC
   Blumenthal, JD
   Nelson, J
   Bastain, TM
   Zijdenbos, A
   Evans, AC
   Rapoport, JL
TI Quantitative brain magnetic resonance imaging in girls with
   attention-deficit/hyperactivity disorder
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT 54th Annual Meeting of the Society-for-Biological-Psychiatry
CY MAY 13-16, 1999
CL WASHINGTON, D.C.
SP Soc Biol Psychiat
ID DEFICIT HYPERACTIVITY DISORDER; WECHSLER-INTELLIGENCE-SCALE;
   CAUDATE-NUCLEUS; HYPERKINETIC DISORDER; GLUCOSE-METABOLISM; CEREBELLAR
   CONTROL; SEX-DIFFERENCES; BASAL GANGLIA; MRI ANALYSIS; WISC-III
AB Background: Anatomic studies of boys with attention-deficit/hyperactivity disorder (ADHD) have detected decreased volumes in total and frontal brain, basal ganglia, and cerebellar vermis. We tested these findings in a sample of girls with ADHD.
   Methods: Anatomic brain magnetic resonance images from 50 girls with ADHD, of severity comparable with that in previously studied boys. and 50 healthy female control subjects, aged 5 to 15 years, were obtained with a 1.5-T scanner with contiguous 2-mm coronal slices and 1.5-mm axial slices. We measured volumes of total cerebrum, frontal lobes, caudate nucleus, globus pallidus, cerebellum, and cerebellar vermis. Behavioral measures included structured psychiatric interviews, parent and teacher ratings, and the Wechsler vocabulary and block design subtests.
   Results: Total brain volume was smaller in girls with ADHD than in control subjects (effect size, 0.40; P=.05). As in our previous study in boys with ADHD, girls with ADHD had significantly smaller volumes in the posterior-inferior cerebellar vermis (lobules VIII-X; effect size, 0.54; P=.04), even when adjusted for total cerebral Volume and vocabulary score. Patients and controls did not differ in asymmetry in any region. Morphometric differences correlated significantly with several ratings of ADHD severity and were not predicted by past or present stimulant drug exposure.
   Conclusions: These results confirm previous findings for boys in the posterior-inferior lobules of the cerebellar vermis. The influence of the cerebellar vermis on pre frontal and striatal circuitry should be explored.
C1 NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
   CHU Hop Nord, Serv Pediat 1, Amiens, France.
   McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
RP Castellanos, FX (reprint author), NIMH, Child Psychiat Branch, Bldg 10,Room 3N-202,10 Ctr Dr,MSC 1600, Bethesda, MD 20892 USA.
RI Giedd, Jay/A-3080-2008; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978
NR 76
TC 254
Z9 257
U1 12
U2 20
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0003-990X
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD MAR
PY 2001
VL 58
IS 3
BP 289
EP 295
DI 10.1001/archpsyc.58.3.289
PG 7
WC Psychiatry
SC Psychiatry
GA 408QR
UT WOS:000167339600010
PM 11231836
ER

PT J
AU Bokde, ALW
   Pietrini, P
   Ibanez, V
   Furey, ML
   Alexander, GE
   Graff-Radford, NR
   Rapoport, SI
   Schapiro, MB
   Horwitz, B
AF Bokde, ALW
   Pietrini, P
   Ibanez, V
   Furey, ML
   Alexander, GE
   Graff-Radford, NR
   Rapoport, SI
   Schapiro, MB
   Horwitz, B
TI The effect of brain atrophy on cerebral hypometabolism in the visual
   variant of Alzheimer disease
SO ARCHIVES OF NEUROLOGY
LA English
DT Article
ID POSTERIOR CORTICAL ATROPHY; AUTOMATED ALGORITHM; GLUCOSE-UTILIZATION;
   FUNCTIONAL FAILURE; DEMENTIA; PET; ASSOCIATION; VOLUME; STIMULATION;
   METABOLISM
AB Background: Brain glucose metabolic rates measured by positron emission tomography can be more affected by partial volume effects in Alzheimer disease (AD) than in healthy aging because of disease-associated brain atrophy.
   Objective: To determine whether the distinct distribution of cerebral metabolic lesions in patients with the visual variant of AD (AD + VS) represents a true index of neuronal/synaptic dysfunction or is the consequence of brain atrophy.
   Setting: Government research hospital.
   Design: Resting cerebral metabolic rate for glucose was measured with positron emission tomography in a cross-sectional study of AD and AD + VS groups and in healthy control subjects. Segmented magnetic resonance im ages were used to correct for brain atrophy.
   Patients: Patients with AD + VS had prominent visual and visuospatial symptoms. There were 15 patients with AD: 10 with AD + VS, and 37 age-matched control subjects. Main Outcome Measure: Measurement of the rate of cerebral glucose metabolism.
   Results: Before atrophy correction, the AD + VS group, compared with the control subjects, showed hypometabolism in primary and extrastriate visual areas and in parietal and superior temporal cortical areas. Compared with the AD group, the AD + VS group showed hypometabolism in visual association areas. After atrophy correction, hypometabolism remained significantly different between patients and controls and between the 2 AD groups.
   Conclusions: The reductions in cerebral hypometabolism represent a true loss of functional activity and are not simply an artifact caused by brain atrophy. The different patterns of hypometabolism indicate the differential development of the lesions between the AD and AD + VS groups.
C1 NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA.
   Univ Pisa, Dept Human & Environm Sci, Pisa, Italy.
   Belle Idee, Div Neuropsychiat, Geneva, Switzerland.
   Arizona State Univ, Arizona Alzheimers Dis Res Ctr, Tempe, AZ USA.
   Arizona State Univ, Dept Psychol, Tempe, AZ USA.
   Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA.
RP Horwitz, B (reprint author), Natl Inst Deafness & Other Commun Disorders, Language Sect, NIH, Bldg 10,Room 6C420, Bethesda, MD 20892 USA.
RI Furey, Maura/H-5273-2013
NR 33
TC 55
Z9 55
U1 1
U2 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0003-9942
J9 ARCH NEUROL-CHICAGO
JI Arch. Neurol.
PD MAR
PY 2001
VL 58
IS 3
BP 480
EP 486
DI 10.1001/archneur.58.3.480
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 410LR
UT WOS:000167441900019
PM 11255453
ER

PT J
AU Crespo, CJ
   Smit, E
   Troiano, RP
   Bartlett, SJ
   Macera, CA
   Andersen, RE
AF Crespo, CJ
   Smit, E
   Troiano, RP
   Bartlett, SJ
   Macera, CA
   Andersen, RE
TI Television watching, energy intake, and obesity in US children - Results
   from the Third National Health and Nutrition Examination Survey,
   1988-1994
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; GENDER
   DIFFERENCES; UNITED-STATES; RISK-FACTORS; ADOLESCENTS; WEIGHT;
   OVERWEIGHT; PREVALENCE
AB Objectives: To examine the relationship between television watching, energy intake, physical activity, and obesity status in US boys and girls, aged 8 to 16 years.
   Methods: We used a nationally representative cross-sectional survey with an in-person interview and a medical examination, which included measurements of height and weight, daily hours of television watching, weekly participation in physical activity, and a dietary interview. Between 1988 and 1994, the Third National Health and Nutrition Examination Survey collected data on 4069 children. Mexican Americans and non-Hispanic blacks were oversampled to produce reliable estimates for these groups.
   Results: The prevalence of obesity is lowest among children watching 1 or fewer hours of television a day, and highest among those watching 4 or more hours of tele- vision a day. Girls engaged in less physical activity and consumed fewer joules per day than bays. A higher percentage of non-Hispanic white bays reported participating in physical activity 5 or more times per week than any other race/ethnic and sex group. Television watching was positively associated with obesity among girls, even after controlling for age, race/ethnicity, family income, weekly physical activity, and energy intake.
   Conclusions: As the prevalence of overweight increases, the need to reduce sedentary behaviors and to promote a more active lifestyle becomes essential. Clinicians and public health interventionists should encourage active lifestyles to balance the energy intake of children.
C1 Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, Baltimore, MD 21224 USA.
   SUNY Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
   Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA.
   NCI, NIH, Bethesda, MD 20892 USA.
   Ctr Dis Control, Div Nutr & Phys Act, Atlanta, GA 30333 USA.
   Ctr Prevent, Atlanta, GA USA.
RP Crespo, CJ (reprint author), Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, 4940 Eastern Ave,Suite 025, Baltimore, MD 21224 USA.
RI Loureiro, Nuno/I-6400-2012; 
OI Loureiro, Nuno/0000-0002-1166-3219; Troiano,
   Richard/0000-0002-6807-989X; Bartlett, Susan/0000-0001-9755-2490
NR 49
TC 418
Z9 435
U1 4
U2 44
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD MAR
PY 2001
VL 155
IS 3
BP 360
EP 365
PG 6
WC Pediatrics
SC Pediatrics
GA 408JX
UT WOS:000167324000007
PM 11231802
ER

PT J
AU Mankani, MH
   Krebsbach, PH
   Satomura, K
   Kuznetsov, SA
   Hoyt, R
   Robey, PG
AF Mankani, MH
   Krebsbach, PH
   Satomura, K
   Kuznetsov, SA
   Hoyt, R
   Robey, PG
TI Pedicled bone flap formation using transplanted bone marrow stromal
   cells
SO ARCHIVES OF SURGERY
LA English
DT Article
ID FIBROBLASTIC CELLS; STEM-CELLS; IN-VIVO; RECONSTRUCTION; PREFABRICATION;
   REGENERATION; OSTEOGENESIS; TISSUES; INVIVO; GRAFTS
AB Hypothesis: Transplanted osteoprogenitor cells derived from cultured bone marrow stromal cells (BMSCs) can be used to fabricate pedicled bone flaps.
   Design: Prospective, randomized experimental trials.
   Setting: Basic science research laboratory.
   Materials: Immunodeficient female NIH-Bg-Nu-Xid mice, aged 3 months.
   Intervention: The BMSCs were harvested from the long bones of C57B1/6 transgenic mice carrying the type I alpha (1) collagen-chloramphenicol acetyl transferase reporter gene construct; their numbers were expanded in tissue culture. Treated mice received BMSC transplantations around the common carotid artery and internal jugular vein, the aorta and its venae comitantes, or the saphenous artery and vein; control mice received a sham transplant in comparable recipient sites.
   Main Outcome Measures: Mice underwent harvesting from 4 weeks to 2 years after transplantation. Transplants were evaluated via histological, immunohistochemical, and angiographic analyses.
   Results: Compared with the controls, which formed no bone, 32 of 37 BMSC-containing transplants formed a vascularized bone island that was perfused specifically and solely by its common carotid artery vascular source. Mature transplants consisted of well-developed lamellar, corticocancellous bone whose osteocytes were derived from the grafted BMSCs; hematopoietic tissue derived from the recipient mouse. Transplants formed as early as 4 weeks and remained stable in size as late as 108 weeks.
   Conclusions: Bone marrow stromal cells can be used to create vascularized bone flaps in mice; these bone constructs are vascularized by their pedicle and therefore can potentially be transferred to a recipient site using microsurgical techniques. These findings provide proof of principle of an additional clinical application of BMSC transplantation techniques.
C1 Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA.
   Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA.
   NHLBI, NIH, Bethesda, MD 20892 USA.
   Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA.
   Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, Tokushima 770, Japan.
RP Mankani, MH (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Dept Surg, 1001 Potrero Ave,Ward 3A, San Francisco, CA 94110 USA.
RI Robey, Pamela/H-1429-2011
OI Robey, Pamela/0000-0002-5316-5576
NR 32
TC 31
Z9 37
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0004-0010
J9 ARCH SURG-CHICAGO
JI Arch. Surg.
PD MAR
PY 2001
VL 136
IS 3
BP 263
EP 270
DI 10.1001/archsurg.136.3.263
PG 8
WC Surgery
SC Surgery
GA 409DB
UT WOS:000167368300001
PM 11231843
ER

PT J
AU Langford, CA
AF Langford, CA
TI Treatment of polyarteritis nodosa, microscopic polyangiitis, and
   Churg-Strauss syndrome: Where do we stand?
SO ARTHRITIS AND RHEUMATISM
LA English
DT Editorial Material
ID GENERALIZED WEGENERS-GRANULOMATOSIS; TERM FOLLOW-UP; PULSE
   CYCLOPHOSPHAMIDE; PROGNOSTIC FACTORS; CLINICAL-FEATURES; RANDOMIZED
   TRIAL; VASCULITIS; STEROIDS; THERAPY; METHOTREXATE
C1 NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
RP Langford, CA (reprint author), NIAID, Immunoregulat Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 44
TC 27
Z9 29
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0004-3591
J9 ARTHRITIS RHEUM
JI Arthritis Rheum.
PD MAR
PY 2001
VL 44
IS 3
BP 508
EP 512
DI 10.1002/1529-0131(200103)44:3<508::AID-ANR96>3.0.CO;2-B
PG 5
WC Rheumatology
SC Rheumatology
GA 485JF
UT WOS:000171750700002
PM 11263763
ER

PT J
AU Heimbacher, C
   Hansen, A
   Pruss, A
   Jacobi, A
   Reiter, K
   Lipsky, PE
   Dorner, T
AF Heimbacher, C
   Hansen, A
   Pruss, A
   Jacobi, A
   Reiter, K
   Lipsky, PE
   Dorner, T
TI Immunoglobulin V-kappa light chain gene analysis in patients with
   Sjogren's syndrome
SO ARTHRITIS AND RHEUMATISM
LA English
DT Article
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; MISMATCH REPAIR PROTEIN; B-CELLS; SOMATIC
   HYPERMUTATION; MOLECULAR MECHANISMS; SELECTIVE INFLUENCES;
   SALIVARY-GLANDS; MICE DEFICIENT; REPERTOIRE; ANTIBODIES
AB Objective. Patients with Sjogren's syndrome (SS) have characteristic lymphocytic infiltration of the salivary glands with a previously reported predominance of V-kappa-bearing B cells and produce a variety of autoantibodies, indicating that there is a humoral autoimmune component in this syndrome. This study was undertaken to determine whether there are primary deviations of immunoglobulin V gene usage, differences in somatic hypermutation, defects of selection, or indications for perturbances of B cell maturation in SS.
   Methods. Individual peripheral B cells from patients with SS were analyzed for their Ig V gene usage, and the findings were compared with results in normal controls.
   Results. Molecular differences, as reflected by findings in the nonproductive V-kappa repertoire of the patients, were identified by an enhanced usage of J(kappa)2 gene segments and a lack of mutational targeting toward RGYW/WRCY sequences compared with controls. A greater usage of V(kappa)1 family members and a reduced frequency of V(kappa)3 gene segments in the productive repertoire suggested differences in selection, possibly driven by antigen. Overall positive selection for mutations, especially for replacements in the complementarity-determining region and for mutations in RGYW/WRCY, similar to that found in controls, was detected.
   Conclusion. Disturbances of strictly regulated B cell maturation, during early B cell development as indicated by prominent J(kappa)2 gene usage and during germinal center reactions as indicated by a lack of targeting of the hypermutation mechanism, might contribute to the emergence of autoimmunity in SS.
C1 Univ Hosp Charite, Dept Med Rheumatol & Clin Immunol, D-10098 Berlin, Germany.
   NIH, Bethesda, MD 20892 USA.
RP Dorner, T (reprint author), Univ Hosp Charite, Dept Med Rheumatol & Clin Immunol, Schumannstr 20-21, D-10098 Berlin, Germany.
NR 29
TC 17
Z9 18
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0004-3591
J9 ARTHRITIS RHEUM
JI Arthritis Rheum.
PD MAR
PY 2001
VL 44
IS 3
BP 626
EP 637
DI 10.1002/1529-0131(200103)44:3<626::AID-ANR111>3.0.CO;2-T
PG 12
WC Rheumatology
SC Rheumatology
GA 485JF
UT WOS:000171750700016
PM 11263777
ER

PT J
AU Otten, PA
   London, RE
   Levy, LA
AF Otten, PA
   London, RE
   Levy, LA
TI 4-Oxo-4H-quinolizine-3-carboxylic acids as Mg2+ selective, fluorescent
   indicators
SO BIOCONJUGATE CHEMISTRY
LA English
DT Article
ID METAL-IONS; F-19 NMR; MAGNESIUM; P-31; SPECTROSCOPY; CATIONS; CALCIUM;
   PLASMA; CELLS; PROBE
AB In this paper, we present the synthesis of a new series of substituted 4-oxo-4H-quinolizine-3-carboxylic acids and the evaluation of their fluorescent response upon complexation with Mg2+ and Ca2+. This has led to the development of the first Mg2+-selective, ratioable fluorescent indicators. We found that 4-oxo-4H-quinolizine-3-carboxylates are excellent fluorophores which show a strong fluorescent response to Mg2+ but not to Ca-2; the latter metal ion often causing interference during Mg2+ measurements with previously described indicators. The dissociation constants of the studied fluorophores-around 1.0 mM-are of the same order of magnitude as is usually observed for intracellular Mg2+.
C1 Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
RP Otten, PA (reprint author), Natl Inst Environm Hlth Sci, Struct Biol Lab, POB 12233,MR-03, Res Triangle Pk, NC 27709 USA.
NR 40
TC 19
Z9 19
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1043-1802
J9 BIOCONJUGATE CHEM
JI Bioconjugate Chem.
PD MAR-APR
PY 2001
VL 12
IS 2
BP 203
EP 212
DI 10.1021/bc000087d
PG 10
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Multidisciplinary; Chemistry, Organic
SC Biochemistry & Molecular Biology; Chemistry
GA 416TU
UT WOS:000167796900010
PM 11312681
ER

PT J
AU Malev, VV
   Kaulin, YA
   Gurnev, PA
   Bezrukov, SM
   Takemoto, J
   Shchagina, LV
AF Malev, VV
   Kaulin, YA
   Gurnev, PA
   Bezrukov, SM
   Takemoto, J
   Shchagina, LV
TI Spatial charge distribution effects in the conductance of syringomycin E
   ion channels formed in lipid bilayers.
SO BIOLOGICHESKIE MEMBRANY
LA Russian
DT Article
ID SURFACE-CHARGE; MEMBRANES; SYRINGAE; CALCIUM
AB Channel-forming activity of syringomycin E produced by phytopathogenic bacterium Pseudomonas syringae pv. syringae was studied. By using planar lipid bilayers modified with syringomycin E, the conductance of single channels formed by antibiotic as a function of the transmembrane potential difference (V), the ionic composition, and pH of the bathing solution was measured for different membranes (charged DOPS/DOPE, and uncharged DPhPC) was measured. For all cases indicated, the current-voltage curves of single channels were superlinear in V and asymmetrical in its sign, the degree of their asymmetry being dependent on variations in the ionic concentration, pH, and the surface membrane charge. The channel conductance did not change when 1 M NaCl was replaced by 1 M RbCl within the range of -250...+250 mV. It suggests the absence of voltage-dependent expanding of channel lumen as a possible reason for the observed superlinearity of current-voltage curves. The equivalent conductance of channels (the ratio of conductance and the electrolyte concentration) in the zero current conditions was practically independent of the NaCl concentration for pH 6 for DOPS/DOPE, pH6. However, the above value was a linear function of the square root concentration of electrolyte for DPhPC. At the same time, the channel conductance for charged bilayers increased monotonically, when pH decreased from 6 to 2, which shows the influence of the surface charge titration. A similar effect was observed when a charge titration was performed with Ca+2-ions. It is shown that the spatially distributed charges stemming from the membrane lipids and the channel-forming molecules are responsible for the observed features of the channels. The estimates based on this model are in agreement with experimental results.
C1 Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia.
   St Petersburg State Univ, Petergof, Russia.
   NIH, Bethesda, MD 20892 USA.
   Russian Acad Sci, St Petersburg Nucl Phys Inst, Gatchina 188350, Russia.
   Utah State Univ, Logan, UT 84322 USA.
RP Malev, VV (reprint author), Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia.
RI Takemoto, Jon/A-5309-2011
OI Takemoto, Jon/0000-0001-9919-9168
NR 29
TC 6
Z9 6
U1 0
U2 0
PU MEZHDUNARODNAYA KNIGA
PI MOSCOW
PA 39 DIMITROVA UL., 113095 MOSCOW, RUSSIA
SN 0233-4755
J9 BIOL MEMBRANY
JI Biol. Membr.
PD MAR-APR
PY 2001
VL 18
IS 2
BP 145
EP 153
PG 9
WC Cell Biology
SC Cell Biology
GA 432CP
UT WOS:000168671500009
ER

PT J
AU Horkay, F
   Tasaki, I
   Basser, PJ
AF Horkay, F
   Tasaki, I
   Basser, PJ
TI Effect of monovalent-divalent cation exchange on the swelling of
   polyacrylate hydrogels in physiological salt solutions
SO BIOMACROMOLECULES
LA English
DT Article
ID IONIC GELS; PHASE-TRANSITIONS; POLYMER-SOLUTIONS; CALCIUM; COMPLEXATION;
   BEHAVIOR; COLLAPSE; SWOLLEN; SODIUM
AB The volume transition induced by monovalent-divalent cation exchange of fully neutralized polyacrylate hydrogels was investigated in aqueous NaCl solutions. The variation of the osmotic swelling pressure, shear modulus, and mixing pressure was measured when Na+ ions were substituted by divalent or trivalent cations. Alkali metal salts move freely throughout the entirely network, and alkaline earth metal salts (CaCl2, SrCl2) promote aggregation of polyacrylate chains, but these aggregates are relatively weak. Transition metal salts (CoCl2, NiCl2) form stronger interchain associates. Rare earth cations (La3+ and Ce3+) bind practically irreversibly to the polymer. Experimental data indicate that transition metal cations modify both the elastic and mixing components of the free energy, while alkaline earth metal cations affect primarily the mixing term. The behavior of freely swollen gels was compared with similar gels subjected to uniaxial compression. In uniaxially compressed gels, volume transition occurs at lower cation concentrations than in the corresponding undeformed gels. The shift of the transition point increases with the deformation ratio and is larger for Co2+ than for Ca2+.
C1 NICHD, Sect Tissue Biophys & Biomimet, Lab Integrat & Med Biophys, NIH, Bethesda, MD 20892 USA.
RP Horkay, F (reprint author), NICHD, Sect Tissue Biophys & Biomimet, Lab Integrat & Med Biophys, NIH, 13 S Dr, Bethesda, MD 20892 USA.
RI Basser, Peter/H-5477-2011
NR 31
TC 88
Z9 89
U1 0
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1525-7797
J9 BIOMACROMOLECULES
JI Biomacromolecules
PD SPR
PY 2001
VL 2
IS 1
BP 195
EP 199
DI 10.1021/bm0056153
PG 5
WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 433JG
UT WOS:000168755800026
PM 11749172
ER

PT J
AU McShane, LM
   Midthune, DN
   Dorgan, JF
   Freedman, LS
   Carroll, RJ
AF McShane, LM
   Midthune, DN
   Dorgan, JF
   Freedman, LS
   Carroll, RJ
TI Covariate measurement error adjustment for matched case-control studies
SO BIOMETRICS
LA English
DT Article
DE case-control study; conditional logistic regression; conditional scores;
   hormones; matched design; measurement error; prostate cancer
ID PERSON MEASUREMENT ERROR; PROSTATE-CANCER; CONFIDENCE-INTERVALS; RISK;
   HORMONES; MODEL
AB We propose a conditional scores procedure for obtaining bias-corrected estimates of log odds ratios from matched case-control data in which one or more covariates are subject to measurement error. The approach involves conditioning on sufficient statistics for the unobservable true covariates that are treated as fixed unknown parameters. For the case of Gaussian nondifferential measurement error, we derive a set of unbiased score equations that can then be solved to estimate the log odds ratio parameters of interest. The procedure successfully removes the bias in naive estimates, and standard error estimates are obtained by resampling methods. We present an example of the procedure applied to data from a matched case-control study of prostate cancer and serum hormone levels, and we compare its performance to that of regression calibration procedures.
C1 NCI, Biometr Res Branch, DCTD, MSC 7434, Bethesda, MD 20892 USA.
   NCI, Biometry Res Grp, DCP, Bethesda, MD 20892 USA.
   Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
   Bar Ilan Univ, Dept Math Stat & Comp Sci, IL-52900 Ramat Gan, Israel.
   Texas A&M Univ, Dept Stat, College Stn, TX 77843 USA.
RP McShane, LM (reprint author), NCI, Biometr Res Branch, DCTD, MSC 7434, Execut Plaza N,Room 739,6130 Execut Blvd, Bethesda, MD 20892 USA.
FU NCI NIH HHS [CA-57030, N01CN45165]
NR 18
TC 13
Z9 13
U1 0
U2 2
PU INTERNATIONAL BIOMETRIC SOC
PI WASHINGTON
PA 1441 I ST, NW, SUITE 700, WASHINGTON, DC 20005-2210 USA
SN 0006-341X
J9 BIOMETRICS
JI Biometrics
PD MAR
PY 2001
VL 57
IS 1
BP 62
EP 73
DI 10.1111/j.0006-341X.2001.00062.x
PG 12
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology; Mathematics
GA 409GW
UT WOS:000167376900008
PM 11252619
ER

PT J
AU Chatterjee, N
   Wacholder, S
AF Chatterjee, N
   Wacholder, S
TI A marginal likelihood approach for estimating penetrance from kin-cohort
   designs
SO BIOMETRICS
LA English
DT Article
DE correlated data; EM algorithm; failure time data; residual familial
   correlation; sandwich variance
ID MUTATION; MODEL
AB The kin-cohort design is a promising alternative to traditional cohort or case-control designs for estimating penetrance of an identified rare autosomal mutation. In this design, a suitably selected sample of participants provides genotype and detailed family history information on the disease of interest. To estimate penetrance of the mutation, we consider a marginal likelihood approach that is computationally simple to implement, more flexible than the original analytic approach proposed by Wacholder et al. (1998, American Journal of Epidemiology 148, 623-629), and more robust than the likelihood approach considered by Call et al. (1999, Genetic Epidemiology 16, 15-39) to presence of residual familial correlation We study the trade-off between robustness and efficiency using simulation experiments. The method is illustrated by analysis of the data from the Washington Ashkenazi Study.
C1 NCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA.
RP Chatterjee, N (reprint author), NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd, Rockville, MD 20892 USA.
NR 12
TC 43
Z9 43
U1 0
U2 1
PU INTERNATIONAL BIOMETRIC SOC
PI WASHINGTON
PA 1441 I ST, NW, SUITE 700, WASHINGTON, DC 20005-2210 USA
SN 0006-341X
J9 BIOMETRICS
JI Biometrics
PD MAR
PY 2001
VL 57
IS 1
BP 245
EP 252
DI 10.1111/j.0006-341X.2001.00245.x
PG 8
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology; Mathematics
GA 409GW
UT WOS:000167376900033
PM 11252606
ER

PT J
AU Dunson, DB
   Perreault, SD
AF Dunson, DB
   Perreault, SD
TI Factor analytic models of clustered multivariate data with informative
   censoring
SO BIOMETRICS
LA English
DT Article
DE Bayesian analysis; factor analysis; historical controls; informative
   missingness; latent variables; MCMC; multilevel data; reproductive
   toxicity
ID LONGITUDINAL DATA; INFERENCE; PRIORS
AB This article describes a general class of factor analytic models for the analysis of clustered multivariate data in the presence of informative missingness. We assume that there are distinct sets of cluster-level latent variables related to the primary outcomes and to the censoring process, and we account for dependency between these latent variables through a hierarchical model. A linear model is used to relate covariates and latent variables to the primary outcomes for each subunit. A generalized linear model accounts for covariate and latent variable effects on the probability of censoring for subunits within each cluster. The model accounts for correlation within clusters and within subunits through a flexible factor analytic framework that allows multiple latent variables and covariate effects on the latent variables. The structure of the model facilitates implementation of Markov chain Monte Carlo methods for posterior estimation. Data from a spermatotoxicity study are analyzed to illustrate the proposed approach.
C1 NIEHS, Biostat Branch, Res Triangle Pk, NC 27709 USA.
   US EPA, NHEERL, Reprod Toxicol Div, Res Triangle Pk, NC 27709 USA.
RP Dunson, DB (reprint author), NIEHS, Biostat Branch, MD A3-03,POB 12233, Res Triangle Pk, NC 27709 USA.
NR 21
TC 16
Z9 16
U1 0
U2 3
PU INTERNATIONAL BIOMETRIC SOC
PI WASHINGTON
PA 1441 I ST, NW, SUITE 700, WASHINGTON, DC 20005-2210 USA
SN 0006-341X
J9 BIOMETRICS
JI Biometrics
PD MAR
PY 2001
VL 57
IS 1
BP 302
EP 308
DI 10.1111/j.0006-341X.2001.00302.x
PG 7
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology; Mathematics
GA 409GW
UT WOS:000167376900041
PM 11252614
ER

PT J
AU Chen, DY
   Patton, JT
AF Chen, DY
   Patton, JT
TI Reverse transcriptase adds nontemplated nucleotides to cDNAs during 5
   '-RACE and primer extension
SO BIOTECHNIQUES
LA English
DT Article
ID RNA; AMPLIFICATION; REPLICATION; SIGNALS; ENDS; GENE
AB In determining the terminal sequences of the genomic dsRNAs of rotavirus by 5'-rapid amplification of cDNA ends (5'-RACE), it was found that most of the viral cDNAs contained extra nucleotides at their 5' termini that had not been reported before on any rotavirus sequence. Although the extra nucleotides could be dA, dC, dG, or dT residues, the extra nucleotides an the cDNAs usually consisted of a single dr residue. Experiments performed with DNA/RNA duplexes indicated that reverse transcriptase has an associated terminal nucleotidyl transferase (TdT)-like activity, which can add nontemplated nucleotides to the 3' ends of DNA, and that reverse transcriptase was responsible for the presence of the extra nucleotides detected on the 5'-RACE cDNAs. The TdT-like activity of reverse transcription was specific for double-stranded substrates (i.e., DNA/DNA or DNA/RNA duplexes) and was active over a wide range of temperatures and enzyme concentrations. Both commercially available Moloney murine leukemia virus and avian myeloblastosis virus reverse transcriptases contained the TdT-like activity. This work implies that 5'-RACE and primer extension assays must be used carefully in determining the terminal sequences of nucleic acids because, under standard reaction conditions, reverse transcriptase can add nontemplated nucleotides ra the 3' ends of cDNAs following template-directed synthesis.
C1 NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Patton, JT (reprint author), NIAID, Infect Dis Lab, NIH, 7 Ctr Dr,MSC 0720,Room 117, Bethesda, MD 20892 USA.
RI Patton, John/P-1390-2014
NR 15
TC 25
Z9 27
U1 0
U2 2
PU EATON PUBLISHING CO
PI NATICK
PA 154 E. CENTRAL ST, NATICK, MA 01760 USA
SN 0736-6205
J9 BIOTECHNIQUES
JI Biotechniques
PD MAR
PY 2001
VL 30
IS 3
BP 574
EP +
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 408QU
UT WOS:000167339800015
PM 11252793
ER

PT J
AU Sada, K
   Zhang, J
   Siraganian, RP
AF Sada, K
   Zhang, J
   Siraganian, RP
TI SH2 domain-mediated targeting, but not localization, of Syk in the
   plasma membrane is critical for Fc epsilon RI signaling
SO BLOOD
LA English
DT Article
ID PROTEIN-TYROSINE KINASE; AFFINITY IGE RECEPTOR; T-CELL ACTIVATION;
   IMMUNOGLOBULIN-E RECEPTOR; BASOPHILIC LEUKEMIA-CELLS; CRYSTAL-STRUCTURE;
   RBL-2H3 CELLS; MAST-CELLS; PHOSPHORYLATION; P72(SYK)
AB Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of subunits of the receptor and the subsequent association with the receptor of the cytosolic protein tyrosine kinase Syk, The current experiments examined the functional importance of membrane association of Syk and the role of the SH2 domain in receptor-mediated signal transduction. Wild-type Syk and chimeric Syk molecules with the c-Src myristylation sequence at the amino terminus were expressed in a Syk-negative mast cell line. Chimeric Syk with the myristylation sequence was membrane associated, and a small fraction was constitutively colocalized with Fc epsilon RI, Lyn, and LAT (linker for T-cell activation) in the glycolipid-enriched microdomains or rafts. However, even under these conditions, the tyrosine phosphorylation of Syk and the downstream propagation of signals required FceRI aggregation. This chimeric Syk was less active than wild-type Syk in Fc epsilon RI-mediated signal transduction. In contrast, a truncated membrane associated form of Syk that lacked the SH2 domains was not tyrosine phosphorylated by receptor aggregation and failed to transduce intracellular signals. These findings suggest that SH2 domain-mediated membrane translocation of Syk is essential for the FceRI-mediated activation of Syk for downstream signaling events leading to histamine release. Furthermore, the localization of Syk in glycolipid-enriched microdomains by itself is not enough to generate or enhance signaling events.(Blood. 2001;97:1352-1359) (C) 2001 by The American Society of Hematology.
C1 Natl Inst Dent & Craniofacial Res, Receptors & Signal Transduct Sect, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA.
RP Sada, K (reprint author), Natl Inst Dent & Craniofacial Res, Receptors & Signal Transduct Sect, Oral Infect & Immun Branch, NIH, Bldg 10-1N-106, Bethesda, MD 20892 USA.
RI Sada, Kiyonao/H-7373-2015
OI Sada, Kiyonao/0000-0001-6124-3100
NR 51
TC 31
Z9 31
U1 0
U2 1
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 1
PY 2001
VL 97
IS 5
BP 1352
EP 1359
DI 10.1182/blood.V97.5.1352
PG 8
WC Hematology
SC Hematology
GA 404TQ
UT WOS:000167117500025
PM 11222380
ER

PT J
AU Lee, CK
   Kim, K
   Welniak, LA
   Murphy, WJ
   Muegge, K
   Durum, SK
AF Lee, CK
   Kim, K
   Welniak, LA
   Murphy, WJ
   Muegge, K
   Durum, SK
TI Thymic emigrants isolated by a new method possess unique phenotypic and
   functional properties
SO BLOOD
LA English
DT Article
ID BONE-MARROW ALLOGRAFTS; PERIPHERAL T-CELLS; IN-VIVO; LYMPHOCYTES;
   THYMOCYTES; MIGRATION; TOLERANCE; SELECTION; MATURATION; ACTIVATION
AB T cells that emigrate from the thymus have primarily been studied in vivo using fluorescent dye injection of the thymus. This study examined the properties of thymocytes that emigrate from cultured thymic lobes in organ culture. Under these conditions, thymic emigrants displayed the expected;phenotype, that of mature thymocytes expressing high levels of T-cell receptor (TCR-alpha beta) and either CD4 or CD8, and were observed to emigrate within 24 hours of positive selection. Emigration was inhibited by cytochalasin D, pertussis toxin, or Clostridium difficile toxin B, implicating an active motility process. Most of the surface markers on alpha beta -thymic emigrants (Thy1, CD44, CD69, CD25, leukocyte functional antigen-1, intercellular adhesion molecule-1, alpha (4)-integrin, alpha (5)- integrin, CD45, and CD28) were expressed at a surface density similar to that on mature intrathymic cells and peripheral splenic T cells. Heterogeneous expression of L-selectin and heat stable antigen (HSA) suggested that subsets emerge from the thymus with a commitment to different migration patterns. The only marker on emigrants not found on either intrathymic cells or mature spleen T cells was CTLA-4, which could dampen the response of emigrants to peripheral antigens. Antigen responsiveness measured in vitro against allogeneic dendritic cells showed a proliferative response comparable to that of splenic T cells. In vivo, however, thymic emigrants failed to induce an acute graft-versus-host reaction in allogeneic severe combined immunodeficiency recipients. This suggests that a mechanism operating in vivo, perhaps tolerance or migration pattern, attenuates the response of emigrants against antigens that did not induce their deletion in the thymus. (Blood, 2001;97:1360-1369) (C) 2001 by The American Society of Hematology.
C1 NCI, Mol Immunoregulat Lab, Div Basic Sci, Sect Cytokines & Immun, Frederick, MD 21702 USA.
   Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD USA.
RP Durum, SK (reprint author), NCI, Mol Immunoregulat Lab, Div Basic Sci, Sect Cytokines & Immun, Bldg 560 Room 31-71, Frederick, MD 21702 USA.
FU NCI NIH HHS [N01-CO-5600]
NR 34
TC 22
Z9 24
U1 0
U2 0
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 1
PY 2001
VL 97
IS 5
BP 1360
EP 1369
DI 10.1182/blood.V97.5.1360
PG 10
WC Hematology
SC Hematology
GA 404TQ
UT WOS:000167117500026
PM 11222381
ER

PT J
AU Bennekou, F
   de Franceschi, L
   Pedersen, O
   Lian, LR
   Asakura, T
   Evans, G
   Brugnara, C
   Christophersen, P
AF Bennekou, F
   de Franceschi, L
   Pedersen, O
   Lian, LR
   Asakura, T
   Evans, G
   Brugnara, C
   Christophersen, P
TI Treatment with NS3623, a novel Cl-conductance blocker, ameliorates
   erythrocyte dehydration in transgenic SAD mice: a possible new
   therapeutic approach for sickle cell disease
SO BLOOD
LA English
DT Article
ID DENSE RED-CELLS; ORAL CLOTRIMAZOLE; KCL COTRANSPORT; VOLUME CONTROL;
   BLOOD-CELLS; CHANNEL; CATION; ANEMIA; MODEL; DEOXYGENATION
AB The dehydration of sickle red blood cells (RBCs) through the Ca-activated K channel depends on the parallel movement of CI ions. To study whether CI-conductance block might prevent dehydration of sickle RBCs, a novel CI-conductance inhibitor (NS3623) was characterized in vitro using RBCs from healthy donors and sickle cell patients and in vivo using normal mice and a transgenic mouse model of sickle cell disease (SAD mice). In vitro, NS3623 reversibly blocked human RBC CI conductance (g(Cl)) with an IC50 value of 210 nmol/L and a maximal block of 95%. In vivo, NS3623 inhibited RBC g(CI) after oral administration to normal mice (ED50 = 25 mg/kg). Although g(CI), at a single dose of 100 mg/kg, was still 70% inhibited 5 hours after dosing, the inhibition disappeared after 24 hours. Repeated administration of 100 mg/kg twice a day for 10 days caused no adverse effects; therefore, this regimen was chosen as the highest dosing for the SAD mice. SAD mice were treated for 3 weeks with 2 daily administrations of 10, 35, and 100 mg/kg NS3623, respectively. The hematocrit increased, and the mean corpuscular hemoglobin concentration decreased in all groups with a concomitant increase in the intracellular cation content. A loss of the densest red cell population was observed in conjunction with a shift from a high proportion of sickled to well-hydrated discoid erythrocytes, with some echinocytes present at the highest dosage, These data indicate feasibility for the potential use of CI-conductance blockers to treat human sickle cell disease. (Blood, 2001;97:1451-1457) (C) 2001 by The American Society of Hematology.
C1 Univ Copenhagen, August Krogh Inst, DK-2100 Copenhagen, Denmark.
   NeuroSearch AS, DK-2750 Ballerup, Denmark.
   Univ Verona, Dept Clin & Expt Med, I-37100 Verona, Italy.
   Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA.
   NHLBI, Sickle Cell Dis Sci Res Grp, Bethesda, MD 20892 USA.
   Harvard Univ, Childrens Hosp, Sch Med, Dept Lab Med & Pathol, Boston, MA 02115 USA.
RP Christophersen, P (reprint author), NeuroSearch AS, Pederstrupvej 93, DK-2750 Ballerup, Denmark.
RI Brugnara, Carlo/A-8041-2010
OI Brugnara, Carlo/0000-0001-8192-8713
NR 33
TC 4
Z9 4
U1 1
U2 5
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 1
PY 2001
VL 97
IS 5
BP 1451
EP 1457
PG 7
WC Hematology
SC Hematology
GA 404TQ
UT WOS:000167117500038
ER

PT J
AU Mackall, CL
   Fry, TJ
   Bare, C
   Morgan, P
   Galbraith, A
   Gress, RE
AF Mackall, CL
   Fry, TJ
   Bare, C
   Morgan, P
   Galbraith, A
   Gress, RE
TI IL-7 increases both thymic-dependent and thymic-independent T-cell
   regeneration after bone marrow transplantation
SO BLOOD
LA English
DT Article
ID MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; IN-VIVO; PERIPHERAL SELECTION;
   GROWTH-FACTORS; RECEPTOR; ANTIGEN; MICE; PROLIFERATION; EXPANSION
AB Thymic-dependent differentiation of bone marrow (BM)-derived progenitors and thymic-independent antigen-driven peripheral expansion of mature T cells represent the 2 primary pathways for T-cell regeneration. These pathways are interregulated such that peripheral T-cell expansion is increased in thymectomized versus thymus-bearing hosts after bone marrow transplantation (BMT). This study shows that this interregulation is due to competition between progeny of these 2 pathways because depletion of thymic progeny leads to increased peripheral expansion in thymus-bearing hosts. To test the hypothesis that competition for growth factors modulates the magnitude of antigen-driven peripheral expansion during immune reconstitution in vivo, a variety of T-cell active cytokines were administered after BMT. Of the cytokines (interleukins) tested (IL-3, IL-12, IL-6, IL-2, and IL-7), IL-2 modestly increased peripheral expansion in the face of increasing numbers of thymic emigrants, whereas IL-7 potently accomplished this. This report also demonstrates that the beneficial effect of IL-7 on immune reconstitution is related to both increases in thymopoiesis as well as a direct increase in the magnitude of antigen-driven peripheral expansion. Therefore, the administration of exogenous IL-7, and to a lesser extent IL-2, abrogates the down-regulation in antigen-driven peripheral expansion that occurs in thymus-bearing hosts after BMT. These results suggest that one mechanism by which T-cell-depleted hosts may support antigen-driven T cell expansion in vivo is via an increased availability of T-cell-active cytokines to support clonal expansion. (Blood, 2001;97:1491-1497) (C) 2001 by The American Society of Hematology.
C1 NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.
   NCI, Expt Immunol Branch, Bethesda, MD 20892 USA.
RP Mackall, CL (reprint author), Bldg 10,Rm 13N240,10 Ctr Dr,MSC 1928, Bethesda, MD 20892 USA.
NR 41
TC 213
Z9 215
U1 0
U2 1
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 1
PY 2001
VL 97
IS 5
BP 1491
EP 1497
DI 10.1182/blood.V97.5.1491
PG 7
WC Hematology
SC Hematology
GA 404TQ
UT WOS:000167117500043
PM 11222398
ER

PT J
AU Bies, J
   Feikova, S
   Markus, J
   Wolff, L
AF Bies, J
   Feikova, S
   Markus, J
   Wolff, L
TI Phosphorylation-dependent conformation and proteolytic stability of
   c-Myb
SO BLOOD CELLS MOLECULES AND DISEASES
LA English
DT Article; Proceedings Paper
CT 2nd International Workshop on Myb Genes (Myb 2000)
CY NOV 22-24, 2000
CL MELBOURNE, AUSTRALIA
DE c-Myb; phosphorylation; conformation; DNA-binding; proteolysis; 26S
   proteasome; Ser/Thr phosphatases
ID ONCOGENIC ACTIVATION; PROTEIN; SITE; DNA; DOMAIN
AB The c-Myb oncoprotein is a critical regulator of hematopoietic cell proliferation and differentiation. Normal c-Myb is rapidly degraded by the ubiquitin-26S proteasome pathway, and instability determinants have been localized within the negative regulatory domain in the carboxyl terminus. Our recent work has shown that, in myeloid cells, inhibition of cellular Ser/Thr protein phosphatases with okadaic acid (OA) causes a rapid increase in c-Myb phosphorylation and 26S proteasome-dependent breakdown [J. Bies, S. Feikova, D. P. Bottaro, and L. Wolff (2000) Oncogene 19, 2846-2854]. Furthermore, phosphoamino acid analyses revealed that the increase in phosphorylation was mainly on threonine residues. Here we investigated the ability of c-Myb to bind DNA following phosphorylation. Our results suggest that the hyperphosphorylated form of c-Myb binds to DNA with affinity very similar to the hypophosphorylated form. Therefore, the increased proteolytic instability of the former cannot be explained by a difference in DNA-binding capacity. Conformational changes in the carboxyl terminus were proposed previously to be a consequence of phosphorylation because we observed phosphorylation-induced alterations in gel electrophoresis mobilities and alterations in recognition by specific monoclonal antibodies. Further support for this notion has come from this study, in which we have detected new degradation products in electrophoretic mobility shift assays, as well as an increased rate of in vitro proteolysis, following OA treatment. We speculate that these alterations in the conformation of the negative regulatory domain expose epitopes on the surface of c-Myb, which in turn can serve as recognition signal(s) for ubiquitin-26S proteasome proteolytic machinery.
C1 Slovak Acad Sci, Inst Canc Res, Mol Virol Lab, Bratislava 83392, Slovakia.
   NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA.
RP Bies, J (reprint author), Slovak Acad Sci, Inst Canc Res, Mol Virol Lab, Bratislava 83392, Slovakia.
NR 16
TC 11
Z9 11
U1 0
U2 0
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1079-9796
J9 BLOOD CELL MOL DIS
JI Blood Cells Mol. Dis.
PD MAR-APR
PY 2001
VL 27
IS 2
BP 422
EP 428
DI 10.1006/bcmd.2001.0400
PG 7
WC Hematology
SC Hematology
GA 443VF
UT WOS:000169361800011
PM 11259165
ER

PT J
AU Wolff, L
   Schmidt, M
   Koller, R
   Haviernik, P
   Watson, R
   Bies, J
   Maciag, K
AF Wolff, L
   Schmidt, M
   Koller, R
   Haviernik, P
   Watson, R
   Bies, J
   Maciag, K
TI Three genes with different functions in transformation are regulated by
   c-Myb in myeloid cells
SO BLOOD CELLS MOLECULES AND DISEASES
LA English
DT Article
DE c-Myb; c-myc; INK4b; tumor suppressor; oncogene; transcriptional
   regulation
ID B-MYB; APOPTOSIS; LEUKEMIA
AB The proto-oncogene c-myb is constitutively expressed in murine leukemia virus-induced myeloid leukemia (MML) due to the integration of virus at this locus. Our recent focus has been the determination of genes regulated by this transcription factor that may be involved in transformation. Data presented here, using conditional expression of Myb in myeloid cells, show that c-M[yb directly transactivates the endogenous c-myc and Bcl-2 genes, which explains at least in part how c-Myb regulates proliferation and survival. In addition, c-Myb prevents expression at the RNA level of the tumor suppressor INK4b gene. This gene encodes a cyclin-dependent kinase inhibitor, p15(INK4b), that is normally upregulated at the mRNA level during myeloid differentiation and promotes growth arrest. The MMLs are generally characterized as differentiated monocytic tumors and possess the phenotype that is normally associated with p15(INK4b) expression, c-Myb inhibits expression of this gene, however, and therefore acts to promote a pathway which is abnormal in mature cells. This activity of c-Myb collaborates with its maintenance of c-myc expression to promote growth. (C) 2001 Academic Press.
C1 NCI, Cellular Oncol Lab, NIH, Bethesda, MD 20892 USA.
   Imperial Coll Sch Med St Marys, Ludwig Inst Canc Res, London, England.
   Slovak Acad Sci, Canc Res Inst, Mol Virol Lab, Bratislava 83392, Slovakia.
RP Wolff, L (reprint author), NCI, Cellular Oncol Lab, NIH, Bldg 37,Rom 2D11,37 Convent Dr MSC 4255, Bethesda, MD 20892 USA.
OI , /0000-0003-0803-4312
NR 11
TC 22
Z9 22
U1 0
U2 0
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1079-9796
J9 BLOOD CELL MOL DIS
JI Blood Cells Mol. Dis.
PD MAR-APR
PY 2001
VL 27
IS 2
BP 483
EP 488
DI 10.1006/bcmd.2001.0409
PG 6
WC Hematology
SC Hematology
GA 443VF
UT WOS:000169361800020
PM 11259171
ER

PT J
AU Tuzmen, S
   Schechter, AN
AF Tuzmen, S
   Schechter, AN
TI Genetic diseases of hemoglobin: diagnostic methods for elucidating
   beta-thalassemia mutations
SO BLOOD REVIEWS
LA English
DT Review
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; DOT-BLOT ANALYSIS;
   PRENATAL-DIAGNOSIS; ALPHA-THALASSEMIA; RAPID DETECTION; GLOBIN GENE;
   ENZYMATIC AMPLIFICATION; OLIGONUCLEOTIDE ARRAYS; CYSTIC-FIBROSIS;
   GENOMIC DNA
C1 NIDDKD, Biol Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Tuzmen, S (reprint author), NIDDR, NIH, LCB, 10 Ctr Dr,Bldg 10-9N318, Bethesda, MD 20892 USA.
RI Tuzmen, Sukru/I-5663-2013; 
OI Tuzmen, Sukru/0000-0003-4822-396X; Schechter, Alan N/0000-0002-5235-9408
NR 65
TC 26
Z9 29
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-960X
J9 BLOOD REV
JI Blood Rev.
PD MAR
PY 2001
VL 15
IS 1
BP 19
EP 29
DI 10.1054/blre.2001.0147
PG 11
WC Hematology
SC Hematology
GA 434RY
UT WOS:000168830700003
PM 11333136
ER

PT J
AU Black, A
   Tilmont, EM
   Handy, AM
   Scott, WW
   Shapses, SA
   Ingram, DK
   Roth, GS
   Lane, MA
AF Black, A
   Tilmont, EM
   Handy, AM
   Scott, WW
   Shapses, SA
   Ingram, DK
   Roth, GS
   Lane, MA
TI A nonhuman primate model of age-related bone loss: A longitudinal study
   in male and premenopausal female rhesus monkeys
SO BONE
LA English
DT Article
DE bone loss; age; nonhuman primates; rhesus; dual-energy X-ray
   absorptiometry (DXA); bone turnover
ID BODY-COMPOSITION; MINERAL DENSITY; SERUM OSTEOCALCIN; NORMAL MEN; WOMEN;
   MASS; OSTEOPOROSIS; MENOPAUSE; TURNOVER; RISK
AB Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models, We used dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD), bone mineral content (BMC), and projected area (PA) at four skeletal sites over 4 years in 20 premenopausal female (8-23 years) and 29 male (8-27 years) rhesus monkeys (Macaca mulatta). Forearm BMD declined with age in both male and female monkeys, Lean mass was positively associated with BMD at all sites in males acid with the distal radius in females, Serum osteocalcin declined and urinary cross-links increased with age in males but not females. Serum 25-hydroxyvitamin D concentrations decreased with ape in females, and a similar trend was observed in males. In conclusion, an age-related decline in forearm BMD was observed in male and female rhesus monkeys, Total body BMC declined over time in older females, with a similar trend in males. Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton. (Bone 28:395-302; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.
C1 NIA, Gerontol Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA.
   Johns Hopkins Univ Hosp, Dept Radiol, Baltimore, MD USA.
   Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA.
RP NIA, Gerontol Res Ctr, Neurosci Lab, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
EM blacka@vms.grc.nia.nih.gov
NR 46
TC 23
Z9 23
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 8756-3282
EI 1873-2763
J9 BONE
JI Bone
PD MAR
PY 2001
VL 28
IS 3
BP 295
EP 302
DI 10.1016/S8756-3282(00)00452-X
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 416UH
UT WOS:000167798200008
PM 11248660
ER

PT J
AU Graber, CJ
   de Almeida, KNF
   Atkinson, JC
   Javaheri, D
   Fukuda, CD
   Gill, VJ
   Barrett, AJ
   Bennett, JE
AF Graber, CJ
   de Almeida, KNF
   Atkinson, JC
   Javaheri, D
   Fukuda, CD
   Gill, VJ
   Barrett, AJ
   Bennett, JE
TI Dental health and viridans streptococcal bacteremia in allogeneic
   hematopoietic stem cell transplant recipients
SO BONE MARROW TRANSPLANTATION
LA English
DT Article
DE viridans streptococcus; bacteremia; neutropenia; transplant; dental;
   resistance
ID BONE-MARROW TRANSPLANTATION; NEUTROPENIC PATIENTS; RISK-FACTORS; CANCER;
   RESISTANT; MALIGNANCIES; PENICILLIN; SEPTICEMIA; INFECTIONS; SHOCK
AB Viridans streptococci were the most common cause of bacteremia in 61 consecutive myeloablative allogeneic hematopoietic stem cell transplant (HSCT) recipients, occurring in 19 of 31 bacteremic patients (61%) during the period of post-transplant neutropenia, Seven of the 19 had more than one viridans streptococcus in the same blood culture. Twenty isolates from 15 patients were Streptococcus mitis, Most viridans streptococci were resistant to norfloxacin, used routinely for prophylaxis, Comparison of the 19 patients with viridans streptococcal bacteremia with a contemporaneous group of 23 allogeneic HSCT recipients with fever and neutropenia but no identified focus of infection found that patients with viridans streptococcal bacteremia were more likely to have severe intraoral pathology while neutropenic (26% vs 0%) and slightly shorter interval between the last dental procedure and the onset of neutropenia (11 vs 14 days). Poor underlying dental health and the use of norfloxacin thus appear to predispose to viridans streptococcal bacteremia.
C1 NIAID, Clin Invest Lab, Clin Mycol Sect, NIH, Bethesda, MD 20892 USA.
   Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA.
   NHLBI, Warren Grant Magnuson Clin Ctr, Dept Clin Pathol, Microbiol Serv,NIH, Bethesda, MD 20892 USA.
   NHLBI, Hematol Branch, Stem Cell Allotransplant Unit, NIH, Bethesda, MD 20892 USA.
RP Bennett, JE (reprint author), NIH, Ctr Clin, Room 11C304, Bethesda, MD 20892 USA.
NR 25
TC 16
Z9 17
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0268-3369
J9 BONE MARROW TRANSPL
JI Bone Marrow Transplant.
PD MAR
PY 2001
VL 27
IS 5
BP 537
EP 542
DI 10.1038/sj.bmt.1702818
PG 6
WC Biophysics; Oncology; Hematology; Immunology; Transplantation
SC Biophysics; Oncology; Hematology; Immunology; Transplantation
GA 417ZV
UT WOS:000167866100011
PM 11313689
ER

PT J
AU Abernethy, DR
   Wesche, DL
   Barbey, JT
   Ohrt, C
   Mohanty, S
   Pezzullo, JC
   Schuster, BG
AF Abernethy, DR
   Wesche, DL
   Barbey, JT
   Ohrt, C
   Mohanty, S
   Pezzullo, JC
   Schuster, BG
TI Stereoselective halofantrine disposition and effect:
   concentration-related QTc prolongation
SO BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
LA English
DT Article
DE halofantrine; QTc; stereoselective clearance
ID EXTENDED-DOSE HALOFANTRINE; FALCIPARUM-MALARIA; PHARMACOKINETICS;
   PLASMA; ENANTIOMERS; WR-171,669; VOLUNTEERS; EFFICACY; THAILAND;
   INTERVAL
AB Aims 1) To characterize the variability of multiple-dose halofantrine pharmacokinetics over time in healthy adults, 2) to correlate the pharmacodynamic measure electrocardiographic (ECG) QT interval with (+)- and (-)-halofantrine plasma concentration and 3) to evaluate the safety and tolerance of halofantrine hydrochloride given over tints to healthy adults.
   Methods Twenty-one healthy subjects were enrolled and 13 completed the study (180 days). Subjects received either 500 mg of racemic halofantrine once daily in the fasted state for 42 days, or placebo, and then halofantrine washout was documented for the following 138 days. Pharmacokinetic and pharmacodynamic (ECG QTc) measurements were obtained.
   Results Mean accumulation half-times (days) for halofantrine were: 7.0 +/- 4.8 [(+)- halofantrine] and 7.3 +/- 4.8 [(-)-halofantrine]. Mean steady-state concentrations were. 97.6 +/- 52.0 ng ml(-1) [( +)-halofantrine] and 48.5 +/- 20.8 [(-)-halofantrine]. Steady-state oral clearance was: 139 +/- 73 l h(-1) [(+)-halofantrine] and 265 +/- 135 l h(-1) [(-)-halofantrine]. Peak plasma concentrations of both (+)- and (-)-halofantrine were attained at 6 h and maximal ECG QTc prolongation was at 4-8 h following drug administration. Fourteen of 16 subjects who received active drug had ECG QTc prolongation that was positively correlated with both (+)- and (-)-halofantrine concentration. The five subjects who received placebo had no demonstrable change in ECG QTc throughout the study.
   Conclusions Halofantrine accumulates extensively and shows high intersubject pharmacokinetic variability, is associated with concentration-related ECG QTc prolongation in healthy subjects, and is clinically well tolerated in this subject group.
C1 Georgetown Univ, Sch Med, Dept Clin Pharmacol, Washington, DC USA.
   Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA.
RP Abernethy, DR (reprint author), NIA, Gerontol Res Ctr, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 32
TC 21
Z9 21
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0306-5251
J9 BRIT J CLIN PHARMACO
JI Br. J. Clin. Pharmacol.
PD MAR
PY 2001
VL 51
IS 3
BP 231
EP 237
DI 10.1046/j.1365-2125.2001.00351.x
PG 7
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 415PU
UT WOS:000167732500007
PM 11298069
ER

PT J
AU Bolan, CD
   Childs, RW
   Procter, JL
   Barrett, AJ
   Leitman, SF
AF Bolan, CD
   Childs, RW
   Procter, JL
   Barrett, AJ
   Leitman, SF
TI Massive immune haemolysis after allogeneic peripheral blood stem cell
   transplantation with minor ABO incompatibility
SO BRITISH JOURNAL OF HAEMATOLOGY
LA English
DT Article
DE ABO incompatibility; haemolysis; PBSC; stem cell transplantation
ID VERSUS-HOST DISEASE; BONE-MARROW TRANSPLANTATION; HEMATOPOIETIC
   PROGENITOR CELLS; CYCLOSPORIN-A; HEMOLYSIS; ENGRAFTMENT; ANTIBODIES;
   RESPONSES; INDUCTION; LEUKEMIA
AB Immune haemolysis as a result of minor ABO incompatibility is an underappreciated complication of haematopoietic transplantation. The increased lymphoid content of peripheral blood stem cell (PBSC) transplants may increase the incidence and severity of this event. We observed massive immune haemolysis in 3 out of 10 consecutive patients undergoing HLA-identical, related-donor PBSC transplants with minor ABO incompatibility. Non-ablative conditioning had been given in 9 of these 10 cases, including two with haemolysis. Cyclosporin alone was used as prophylaxis against graft-vs.-host disease (GVHD). Catastrophic haemolysis of 78% of the circulating red cell mass led to anoxic death in the first case seen, but severe consequences were avoided by early, vigorous donor-compatible red cell transfusions in the subsequent two cases, Haemolysis began 7-11 d after PBSC infusion and all patients with haemolysis had a positive direct antiglobulin test (DAT), with eluate reactivity against the relevant recipient antigen. However, neither the intensity of the DAT the donor isohaemagglutinin titre, nor other factors could reliably be used to predict the occurrence of haemolysis. Our data indicate that haemolysis may be frequent and severe after transplantation of minor ABO-incompatible PBSCs when utilizing cyclosporin alone to prevent GVHD. Meticulous clinical monitoring and early, vigorous donor-compatible red cell transfusions should be practiced in all instances.
C1 NHLBI, Dept Transfus Med, Warren Grant Magnuson Clin Ctr, NIH, Bethesda, MD 20892 USA.
   NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA.
RP Leitman, SF (reprint author), NHLBI, Dept Transfus Med, Warren Grant Magnuson Clin Ctr, NIH, Bldg 10,Room 1C711, Bethesda, MD 20892 USA.
NR 35
TC 59
Z9 62
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0007-1048
J9 BRIT J HAEMATOL
JI Br. J. Haematol.
PD MAR
PY 2001
VL 112
IS 3
BP 787
EP 795
DI 10.1046/j.1365-2141.2001.02587.x
PG 9
WC Hematology
SC Hematology
GA 414TL
UT WOS:000167682200037
PM 11260085
ER

PT J
AU Mondoro, TH
   Ryan, BB
   Hrinczenko, BW
   Schechter, AN
   Vostal, JG
   Alayash, AI
AF Mondoro, TH
   Ryan, BB
   Hrinczenko, BW
   Schechter, AN
   Vostal, JG
   Alayash, AI
TI Biological action of nitric oxide donor compounds on platelets from
   patients with sickle cell disease
SO BRITISH JOURNAL OF HAEMATOLOGY
LA English
DT Article
DE nitric oxide; platelets; sickle cell anaemia
ID IIB-IIIA COMPLEX; ACTIVATED PLATELETS; OXYGEN-AFFINITY; RELAXING FACTOR;
   ENDOTHELIUM; NO; ERYTHROCYTES; THROMBOSPONDIN; PROSTACYCLIN; METABOLITES
AB Several lines of evidence point to the potential role of nitric oxide (NO) in the pathophysiology, as well as in the therapy, of sickle cell disease (SCD). In this study, we compared the effects of NO on platelets from normal individuals and from patients with SCD. Three NO donors were used to deliver NO to platelets: sodium 2-(N, N-diethylamino)-diazenolate-2-oxide (DEANO), S-nitrosocysteine (CysNO) and sodium trioxdintrate (OXINO or Angeli's salt). ADP-induced platelet aggregation, CD62P expression, PAC-1 binding and calcium elevation were evaluated in paired studies of normal and SCD subjects. DEANO significantly reduced aggregation in SCD platelets compared with normal platelets. DEANO similarly reduced the extent of CD62P expression in SCD platelets. All NO donors reduced PAC-1 binding, but there were no significant differences between platelets from normal or SCD subjects. Calcium elevation, as induced by ADP, was not altered by the presence of NO donors. However, when platelets were stimulated with thrombin, there was an increased initial response of SCD platelets compared with normal platelets. Taken together, these data suggest that the mode of NO delivery to platelets may produce various physiological responses and the optimization of NO delivery may contribute to reducing platelet aggregation in sickle cell disease.
C1 US FDA, Ctr Biol Evaluat & Res, Lab Plasma Derivat, Bethesda, MD 20892 USA.
   US FDA, Ctr Biol Evaluat & Res, Lab Cellular Hematol, Bethesda, MD 20892 USA.
   NIDDKD, Biol Chem Lab, NIH, Bethesda, MD USA.
RP Alayash, AI (reprint author), US FDA, Ctr Biol Evaluat & Res, Lab Plasma Derivat, Bldg 29,Room 112,8800 Rockville Pike, Bethesda, MD 20892 USA.
OI Schechter, Alan N/0000-0002-5235-9408
NR 31
TC 18
Z9 18
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0007-1048
J9 BRIT J HAEMATOL
JI Br. J. Haematol.
PD MAR
PY 2001
VL 112
IS 4
BP 1048
EP 1054
DI 10.1046/j.1365-2141.2001.02623.x
PG 7
WC Hematology
SC Hematology
GA 424YV
UT WOS:000168262300029
PM 11298605
ER

PT J
AU Verdier-Pinard, P
   Lansiaux, A
   Bailly, C
AF Verdier-Pinard, P
   Lansiaux, A
   Bailly, C
TI Combretastatin A4 phosphate
SO BULLETIN DU CANCER
LA French
DT Article
ID ANTIMITOTIC NATURAL-PRODUCTS; ANTINEOPLASTIC AGENTS; A-4 PHOSPHATE;
   COMBRETUM-CAFFRUM; SOLID TUMORS; TUBULIN; INHIBITORS; PRODRUG; POTENT;
   CANCER
C1 NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, Frederick, MD 21702 USA.
   Ctr Oscar Lambret, Lab Pharmacol Antitumorale, F-59045 Lille, France.
   INSERM, U524, F-59045 Lille, France.
RP Verdier-Pinard, P (reprint author), NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, POB B,Bldg 469,Room 140, Frederick, MD 21702 USA.
NR 47
TC 5
Z9 5
U1 0
U2 3
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0007-4551
J9 B CANCER
JI Bull. Cancer
PD MAR
PY 2001
VL 88
IS 3
BP 235
EP 239
PG 5
WC Oncology
SC Oncology
GA 423UR
UT WOS:000168196600001
PM 11313199
ER

PT J
AU De Vries, G
   Sherman, A
AF De Vries, G
   Sherman, A
TI From spikers to bursters via coupling: Help from heterogeneity
SO BULLETIN OF MATHEMATICAL BIOLOGY
LA English
DT Article
ID PANCREATIC BETA-CELLS; BURSTING OSCILLATIONS; MODEL; CA2+; CLUSTERS;
   CURRENTS; NEURONS; ISLETS; SLOW
AB It has been shown previously that identical spiking cells, incapable of bursting by themselves, may burst under weak diffusive coupling conditions. With stronger coupling, the coupled system reverts to bursting can be recovered by introducing heterogeneity in the model parameters. For a two-cell system, we explain the phenomenon with bifurcation analysis. For larger clusters of coupled cells, we demonstrate by numerical simulation that the phenomenon carries over. In addition, we use a perturbation analysis to deduce the dependence of the heterogeneity parameter used in the bifurcation analysis on the original heterogeneity parameters and the coupling strength. Implications of the phenomenon of emergent bursting are discussed in the context of electrical activity in pancreatic beta cells. (C) 2001 Society for Mathematical Biology.
C1 Univ Alberta, Dept Math Sci, Edmonton, AB T6G 2G1, Canada.
   NIDDK, Math Res Branch, NIH, Bethesda, MD 20892 USA.
RP De Vries, G (reprint author), Univ Alberta, Dept Math Sci, Edmonton, AB T6G 2G1, Canada.
NR 24
TC 36
Z9 36
U1 1
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0092-8240
J9 B MATH BIOL
JI Bull. Math. Biol.
PD MAR
PY 2001
VL 63
IS 2
BP 371
EP 391
DI 10.1006/bulm.2001.0228
PG 21
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology
GA 411LZ
UT WOS:000167502700008
PM 11276531
ER

PT J
AU Lowe, ES
   Kitchen, BJ
   Erdmann, G
   Stork, LC
   Bostrom, BC
   Hutchinson, R
   Holcenberg, J
   Reaman, GH
   Woods, W
   Franklin, J
   Widemann, BC
   Balis, FM
   Murphy, RF
   Adamson, PC
AF Lowe, ES
   Kitchen, BJ
   Erdmann, G
   Stork, LC
   Bostrom, BC
   Hutchinson, R
   Holcenberg, J
   Reaman, GH
   Woods, W
   Franklin, J
   Widemann, BC
   Balis, FM
   Murphy, RF
   Adamson, PC
TI Plasma pharmacokinetics and cerebrospinal fluid penetration of
   thioguanine in children with acute lymphoblastic leukemia: a
   collaborative pediatric oncology branch, NCI, and Children's Cancer
   Group study
SO CANCER CHEMOTHERAPY AND PHARMACOLOGY
LA English
DT Article
DE 6-thioguanine; 8-OH-thioguanine; childhood; leukemia; pharmacokinetics
ID INTRAVENOUS-INFUSION; ALDEHYDE OXIDASE; PHASE-I; MERCAPTOPURINE;
   6-MERCAPTOPURINE; 6-THIOGUANINE; TRIAL
AB Purpose: In preclinical studies, thioguanine (TG) has been shown to be more potent than the standard acute lymphoblastic leukemia (ALL) maintenance agent, mercaptopurine (MP), suggesting that TG may be more efficacious than MP in the treatment of childhood ALL. As part of a pilot trial in which TG was used in place of MP, we studied the plasma pharmacokinetics of oral TG and measured steady-state plasma and CSF TG concentrations during a continuous intravenous infusion (CIVI) in children with newly diagnosed standard-risk ALL. Methods: Nine plasma samples were collected after each patient's first 60 mg/m(2) oral TG dose during maintenance. CIVI TG (20 mg/m(2)/h over 24 h) was administered during the consolidation phase of therapy, and simultaneous plasma and CSF samples were collected near the end of the infusion. TG was measured by reverse-phase HPLC with ultraviolet detection. Erythrocyte TG nucleotide (TGN) concentrations were measured 7 days after a course of CIVI TG and prior to the start of each maintenance cycle. Results: After oral TG (n = 35), the mean (+/- SD) peak plasma concentration was 0.46+/-0.68 muM and the AUC ranged from 0.18 to 9.5 muM . h (mean 1.5 muM. h). Mean steady-state plasma and CSF TG concentrations during CIVI (n=33) were 2.7 and 0.5 muM, respectively. The mean (+/-SD) TG clearance was 935+/-463 ml/min per m(2). Plasma TG concentrations did not correlate with erythrocyte TGN concentrations after oral or CIVI TG. The 8-OH-TG metabolite was detected in plasma and CSF, Conclusions: TG concentrations that are cytotoxic to human leukemia cell lines can be achieved in plasma after a 60 mg/m(2) oral dose of TG and in plasma and CSF during CIVI of TG.
C1 NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.
   N Dakota State Univ, Fargo, ND 58105 USA.
   Childrens Hosp, Denver, CO 80218 USA.
   Childrens Hosp & Clin, Minneapolis, MN 55404 USA.
   Univ Michigan, Med Ctr, Ann Arbor, MI 48109 USA.
   Childrens Hosp & Med Ctr, Seattle, WA 98105 USA.
   Childrens Hosp, Natl Med Ctr, Washington, DC 20010 USA.
   Univ Minnesota Hosp, Minneapolis, MN 55455 USA.
   Childrens Hosp, Los Angeles, CA 90027 USA.
RP Lowe, ES (reprint author), NCI, Pediat Oncol Branch, 10 Ctr Dr,Bldg 10,Room 13C103, Bethesda, MD 20892 USA.
FU NCRR NIH HHS [5 MO1 RR00069]
NR 22
TC 16
Z9 16
U1 0
U2 1
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0344-5704
J9 CANCER CHEMOTH PHARM
JI Cancer Chemother. Pharmacol.
PD MAR
PY 2001
VL 47
IS 3
BP 199
EP 205
PG 7
WC Oncology; Pharmacology & Pharmacy
SC Oncology; Pharmacology & Pharmacy
GA 413YZ
UT WOS:000167640300002
PM 11320662
ER

PT J
AU Cholody, WM
   Kosakowska-Cholody, T
   Michejda, CJ
AF Cholody, WM
   Kosakowska-Cholody, T
   Michejda, CJ
TI Bisimidazoacridones induce a potent cytostatic effect in colon tumor
   cells that sensitizes them to killing by UCN-01
SO CANCER CHEMOTHERAPY AND PHARMACOLOGY
LA English
DT Article
DE bisimidazoacridones; colon cancer; cell cycle; cytostasis
ID PROTEIN-KINASE-C; 7-HYDROXYSTAUROSPORINE UCN-01; BETA-GALACTOSIDASE;
   INDUCED CYTOTOXICITY; CANCER-CHEMOTHERAPY; APOPTOSIS; P53; ARREST;
   CAMPTOTHECIN; ENHANCEMENT
AB Purpose: To determine the ability of WMC26, a prototypic bisimidazoacridone (BIA), to induce apoptosis in sensitive colon adenocarcinoma cells and to advance the hypothesis that cancer cells that are growth-arrested by WMC26 are predisposed to undergo apoptotic death by abrogators of cell cycle checkpoints. Methods: The antiproliferative activity of WMC26 was examined in detail by a 4-day MTT assay, cell counting, BrdU incorporation and a two-color LIVE/DEAD assay. To detect apoptosis a number of established techniques were used, including gel electrophoresis, flow cytometry, and confocal laser microscopy of treated cells. The activity of senescence-associated beta -galactosidase in treated cells was also analyzed. Results: WMC26, at physiological concentrations, induced complete and longlasting growth arrest of HCT116 cells in culture but did not trigger cell death. The growth-arrested cells (blocked at G(1) and G(2)/M cell cycle checkpoints) did not synthesize DNA but were metabolically active and had intact plasma membranes. Although they resembled the senescence-like phenotype reported to be induced by treatment with some antitumor agents, the cells did not express senescence-associated P-galactosidase, an indicator of the senescence-like state. Treatment of WMC26 growth-arrested cells with 1 muM UCN-01, an abrogator of the G(2)/M checkpoint, caused a very rapid (1 h) change in morphology and cell death within 72 h. Conclusions: BIAs do not induce apoptosis in sensitive colon tumor cells. They are highly cytostatic but only marginally toxic to the cells even at concentrations 100-fold higher than those sufficient for complete growth arrest. In this respect WMC26 differs from some other DNA-interacting antitumor agents that produce cell growth arrest at low concentrations but are toxic at higher doses. The complete growth arrest induced by WMC26 in colon cancer cells sensitized them to apoptotic death induced by UCN-01. This finding suggests that a combination of WMC26 and cyclin-dependent kinase inhibitors may be an attractive treatment method for colon cancer that utilizes the highly tumor-selective activity of WMC26.
C1 NCI, Struct Biophys Lab, Mol Aspects Drug Design, Frederick, MD 21702 USA.
RP Michejda, CJ (reprint author), NCI, Struct Biophys Lab, Mol Aspects Drug Design, Frederick, MD 21702 USA.
NR 32
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0344-5704
J9 CANCER CHEMOTH PHARM
JI Cancer Chemother. Pharmacol.
PD MAR
PY 2001
VL 47
IS 3
BP 241
EP 249
DI 10.1007/s002800000234
PG 9
WC Oncology; Pharmacology & Pharmacy
SC Oncology; Pharmacology & Pharmacy
GA 413YZ
UT WOS:000167640300008
PM 11320668
ER

PT J
AU Dimitrov, NV
   Leece, CM
   Tompkins, ER
   Seymour, E
   Bennink, M
   Gardiner, J
   Crowell, J
   Hawk, E
   Nashawaty, M
   Bennett, JL
AF Dimitrov, NV
   Leece, CM
   Tompkins, ER
   Seymour, E
   Bennink, M
   Gardiner, J
   Crowell, J
   Hawk, E
   Nashawaty, M
   Bennett, JL
TI Oltipraz concentrations in plasma, buccal mucosa cells, and lipids:
   Pharmacological studies
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID CHEMOPREVENTIVE AGENT; CANCER; ADDUCTS; SERUM; RISK
AB Oltipraz is considered one of the most potent cancer chemoprevention agents, as shown in preclinical studies. Its pharmacological effects in humans have been associated with unusual toxicity affecting the fingers and toes. This study was designed to test intermittent dosing schedules using two dosage levels: 500 mg as a single weekly dose and 200 mg as a biweekly dose, each for 30 days. Fifteen men and women were studied in each dosing group. All were heavy smokers considered to be at high risk for developing lung cancer, Plasma, buccal mucosa cell, and lipoprotein concentrations were measured at different intervals corresponding to the time period when most of the adverse effects occur, No serious toxicities were observed using these doses and schedules, The plasma and buccal mucosa cell concentrations of Oltipraz showed substantial interindividual variations at each sampling. Some subjects had no detectable plasma or buccal mucosal cell Oltipraz concentrations. The distribution of Oltipraz incorporation into the lipid fractions and albumin was changed by the administration of different schedules of Oltipraz, The results of this study suggest that the intermittent dosing is well tolerated and does not result in steady state in plasma or buccal mucosa cells. The variation and lack of detectable Oltipraz concentration in plasma, buccal mucosa cells, and lipids may affect both the toxicity and the pharmacological effects when these doses and schedules are used.
C1 Michigan State Univ, Dept Med, E Lansing, MI 48824 USA.
   Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA.
   Michigan State Univ, Dept Epidemiol & Stat, E Lansing, MI 48824 USA.
   Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
   NCI, Div Canc Prevent, Bethesda, MD 20892 USA.
   NCI, Gastrointestinal & Other Canc Res Grp, Bethesda, MD 20892 USA.
RP Dimitrov, NV (reprint author), Michigan State Univ, Dept Med, B-226 Life Sci Bldg, E Lansing, MI 48824 USA.
OI Gardiner, Joseph/0000-0003-2605-6478
FU NCI NIH HHS [N01-CN-75125]
NR 18
TC 7
Z9 7
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAR
PY 2001
VL 10
IS 3
BP 201
EP 207
PG 7
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 418BJ
UT WOS:000167869600006
PM 11303588
ER

PT J
AU Duell, EJ
   Millikan, RC
   Pittman, GS
   Winkel, S
   Lunn, RM
   Tse, CKJ
   Eaton, A
   Mohrenweiser, HW
   Newman, B
   Bell, DA
AF Duell, EJ
   Millikan, RC
   Pittman, GS
   Winkel, S
   Lunn, RM
   Tse, CKJ
   Eaton, A
   Mohrenweiser, HW
   Newman, B
   Bell, DA
TI Polymorphisms in the DNA repair gene XRCC1 and breast cancer
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID BASE EXCISION-REPAIR; POLY(ADP-RIBOSE) POLYMERASE; LIGASE-III;
   CIGARETTE-SMOKING; DAMAGE; RISK; SUSCEPTIBILITY; PROTEIN; HUMANS;
   PROFICIENCY
AB X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association of polymorphisms in XRCC1 (codon 194 Arg --> Trp and codon 399 Arg --> Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina. No association was observed between XRCC1 codon 194 genotype and breast cancer, and odds ratios (ORs) were not modified by smoking or radiation exposure. A positive association for XRCC1 codon 399 Arg/Gln or Gln/Gln genotypes compared with Arg/Arg was found among African Americans (253 cases, 266 controls; OR = 1,7, 95% confidence interval, 1,1-2,4) but not whites (386 cases, 381 controls; OR = 1,0, 95% confidence interval, 0,8-1,4), Among African-American women, ORs for the duration of smoking were elevated among women with XRCC1 codon 399 Arg/Arg genotype (trend test; P < 0.001) but not Arg/Gln or Gln/Gln (P = 0,23), There was no difference in OR for smoking according to XRCC1 codon 399 genotype in white women. ORs for occupational exposure to ionizing radiation were stronger for African-American and white women with codon 399 Arg/Arg genotype, High-dose radiation to the chest was more strongly associated with breast cancer among white women with XRCC1 codon 399 Arg/Arg genotype, Our results suggest that XRRC1 codon 399 genotype may influence breast cancer risk, perhaps by modifying the effects of environmental exposures. However, interpretation of our results is Limited by incomplete knowledge regarding the biological function of XRCC1 alleles.
C1 Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
   NIEHS, Lab Computat Biol & Risk Assessment, Res Triangle Pk, NC 27709 USA.
   Univ Calif Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA 94550 USA.
   Queensland Univ Technol, Sch Publ Hlth, Kelvin Grove, Qld 4059, Australia.
   Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
RP Millikan, RC (reprint author), Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, CB 7400, Chapel Hill, NC 27599 USA.
FU NCI NIH HHS [P50-CA58223]; NIEHS NIH HHS [P-42-ES05948]
NR 46
TC 210
Z9 221
U1 1
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAR
PY 2001
VL 10
IS 3
BP 217
EP 222
PG 6
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 418BJ
UT WOS:000167869600008
PM 11303590
ER

PT J
AU Hoque, A
   Lippman, SM
   Boiko, IV
   Atkinson, EN
   Sneige, N
   Sahin, A
   Weber, DM
   Risin, S
   Lagios, MD
   Schwarting, P
   Colburn, WJ
   Dhingra, K
   Follen, M
   Kelloff, GJ
   Boone, CW
   Hittelman, WN
AF Hoque, A
   Lippman, SM
   Boiko, IV
   Atkinson, EN
   Sneige, N
   Sahin, A
   Weber, DM
   Risin, S
   Lagios, MD
   Schwarting, P
   Colburn, WJ
   Dhingra, K
   Follen, M
   Kelloff, GJ
   Boone, CW
   Hittelman, WN
TI Quantitative nuclear morphometry by image analysis for prediction of
   recurrence of ductal carcinoma in situ of the breast
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID SURGICAL-ADJUVANT-BREAST; IN-SITU; LOCAL RECURRENCE; PROSTATE-CANCER;
   INTEROBSERVER REPRODUCIBILITY; CONSERVING THERAPY; RESIDUAL DISEASE;
   EPITHELIAL-CELLS; GRADE; INSITU
AB Clinical management of ductal carcinoma in situ (DCIS) remains a challenge because significant proportions of patients experience recurrence after conservative surgical treatment. Unfortunately, it is difficult to prospectively identify, using objective criteria, patients who are at high risk of recurrence and might benefit from additional treatment. We conducted a multi-institutional, collaborative case-control study to identify nuclear morphometric features that would be useful for identifying women with DCIS at the highest risk of recurrence, Tissue sections of archival breast tissue of 29 women with recurrent and 73 matched women with nonrecurrent DCIS were stained for DNA, and nuclei in the DCIS lesions were evaluated by image analysis. A dear correlation between mean fractal2_area (FA2) and nuclear grade was observed (P < 0,001), allowing an objective determination of nuclear grade. Several nuclear morphometric features, including mean and variance of variation of radius, mean area, mean and variance of frequency of high boundary harmonics (FQH), and variance in sphericity, were found to be useful in discriminating recurrent from nonrecurrent DCIS subjects. However, the nuclear features associated with recurrence differed between high- and low-grade lesions. For Lesions with high FA2 (nuclear grade 3), mean variation of radius, mean FQH, and mean area alone yielded recurrence odds ratios of 4.55 [95% confidence interval (CI) 0,45-45,961, 3.86 (95% CI, 0,88-16,98), 2.90 (95% CI, 0,31-27,2), respectively. Using a summed feature model, high-FA2 lesions showing three poor prognostic features had an odds ratio of 15.63 (95% CI, 1,22-200), compared with those with zero or one poor prognostic feature. Lesions with low mean FA2 (nuclear grade I or 2) showing high variances in sphericity and FQH had an odds ratio of 7.71 (95% CI, 1,77-33,60), Addition of other features did not enhance the odds ratio or its significance. These results suggest that nuclear image analysis of I)CIS lesions may provide an adjunctive tool to conventional pathological analysis, both for the objective assessment of nuclear grade and for the identification of features that predict patient outcome.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Biomath, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA.
   St Marys Med Sch, Breast Canc Consultat Serv, Van Nuys, CA 91405 USA.
   Thomas Jefferson Univ Hosp, Dept Surg Pathol, Philadelphia, PA 19107 USA.
   Tarzana Med Ctr, Dept Pathol, Tarzana, CA 91356 USA.
   Hoffmann La Roche Inc, Nutley, NJ 07110 USA.
   NCI, Div Canc Prevent & Control, Chemoprevent Branch, NIH, Bethesda, MD 20892 USA.
RP Hittelman, WN (reprint author), Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Box 019,1515 Holcombe Blvd, Houston, TX 77030 USA.
FU NCI NIH HHS [CN-65004]
NR 53
TC 14
Z9 16
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAR
PY 2001
VL 10
IS 3
BP 249
EP 259
PG 11
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 418BJ
UT WOS:000167869600013
PM 11303595
ER

PT J
AU Caporaso, NE
   Lerman, C
   Audrain, J
   Boyd, NR
   Main, D
   Issaq, HJ
   Utermahlan, B
   Falk, RT
   Shields, P
AF Caporaso, NE
   Lerman, C
   Audrain, J
   Boyd, NR
   Main, D
   Issaq, HJ
   Utermahlan, B
   Falk, RT
   Shields, P
TI Nicotine metabolism and CYP2D6 phenotype in smokers
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID POLYMORPHISM; ALLELES
AB We tested the hypothesis that the polymorphic enzyme CYP2D6 is related to nicotine metabolism in 261 healthy subjects enrolling in a smoking cessation clinic. Subjects completed a questionnaire, were given dextromethorphan, and contributed a urine and blood sample. The CYP2D6 phenotype (based on a determination of dextromethorphan and metabolites in an aliquot of overnight urine) and genotype (based on characterization of CYP2D6 variant alleles by a PCR-based method on a subset) were determined. Seventeen poor metabolizers (6.5%) were observed among 261 phenotyped smokers. Nicotine and it chief metabolites, cotinine and trans-3'-hydroxycotinine were measured in the urine and adjusted for pH. All of the nicotine metabolite levels were significantly related to usual and recent smoking. Neither levels of smoking nor nicotine metabolites overall exhibited a relationship to the CYP2D6-deficient metabolizer phenotype, The ratio of nicotine:cotinine + trans-3'-hydroxycotinine, stratified by time since the last cigarette, was unrelated to gender, age, education, race (white/African American), recent alcohol or caffeine consumption, or smoking practices. Subjects in either the Lowest quintile or decile metabolic ratio (ultrametabolizers) exhibited a significantly lower nicotine:cotinine + trans-3'-hydroxycotinine ratio after adjustment for recent smoking, pH, and other factors. These data suggest that the polymorphic CYP2D6 gene is not a major contributor to nicotine metabolism in tobacco smokers but may influence the disposition of nicotine in the small subset of the population who are CYP2D6 ultrametabolizers.
C1 NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   Georgetown Univ, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA.
   NCI, Frederick Canc Res & Dev Ctr, Lab Chem Synthet & Anal, Frederick, MD 21701 USA.
   NCI, Human Carcinogenesis Lab, Div Canc Etiol, Bethesda, MD 20892 USA.
RP Caporaso, NE (reprint author), NCI, Div Canc Epidemiol & Genet, Execut Plaza S,Room 7116,6120 Execut Blvd, Bethesda, MD 20892 USA.
RI Shields, Peter/I-1644-2012
NR 15
TC 37
Z9 40
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAR
PY 2001
VL 10
IS 3
BP 261
EP 263
PG 3
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 418BJ
UT WOS:000167869600014
PM 11303596
ER

PT J
AU Colbert, LH
   Hartman, TJ
   Malila, N
   Limburg, PJ
   Pietinen, P
   Virtamo, J
   Taylor, PR
   Albanes, D
AF Colbert, LH
   Hartman, TJ
   Malila, N
   Limburg, PJ
   Pietinen, P
   Virtamo, J
   Taylor, PR
   Albanes, D
TI Physical activity in relation to cancer of the colon and rectum in a
   cohort of male smokers
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID COLORECTAL-CANCER; RISK; MEN; WOMEN; HEALTH
AB We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study, 152 colon and 104 rectal cancers were documented during up to 12 years of follow-up, For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0,34-1,041, whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003), Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon ((RR, 0.87; CI, 0,40-1,92), There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0,16-0,71), For rectal cancer, there were risk reductions for those in Light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0,04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.
C1 NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, Bethesda, MD 20892 USA.
   Natl Publ Hlth Inst, FIN-00300 Helsinki, Finland.
RP Colbert, LH (reprint author), NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, 6006 Execut Blvd,Suite 321,MSC 7058, Bethesda, MD 20892 USA.
RI Albanes, Demetrius/B-9749-2015
FU NCI NIH HHS [N01 CN 45165]
NR 24
TC 72
Z9 76
U1 0
U2 6
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAR
PY 2001
VL 10
IS 3
BP 265
EP 268
PG 4
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 418BJ
UT WOS:000167869600015
PM 11303597
ER

PT J
AU Campbell, M
   Aprelikova, ON
   van der Meer, R
   Woltjer, RL
   Yee, CJ
   Liu, ET
   Jensen, RA
AF Campbell, M
   Aprelikova, ON
   van der Meer, R
   Woltjer, RL
   Yee, CJ
   Liu, ET
   Jensen, RA
TI Construction and characterization of recombinant adenoviruses expressing
   human BRCA1 or murine Brca1 genes
SO CANCER GENE THERAPY
LA English
DT Article
DE adenoviruses; growth inhibition; cell cycle; tumor suppressor
ID MAMMARY EPITHELIAL-CELLS; TRANSCRIPTIONAL ACTIVATION; MAMMALIAN-CELLS;
   DNA-REPAIR; GROWTH; CYCLE; INDUCTION; APOPTOSIS; MUTATION; ARREST
AB Recombinant adenoviruses expressing human BRCA1 (AdBRCA1), murine Brca1 (AdBrca1), three clinically relevant human mutant BRCA1 proteins (t340, C61G, and 1853Stop), or a murine Brca1 C-terminal deletion mutant were constructed and evaluated in vitro. These recombinants were capable of transducing high-level transgene expression to a wide variety of cell lines in vitro. Three independent methods were utilized to monitor cell growth following transduction with these recombinants. High-level expression of either the human or mouse wild-type BRCA1 protein was incompatible with maximal levels of cell growth. AdBRCA1 transduction inhibited the outgrowth of several human breast and ovarian cell lines in colony formation assays. Flow cytometric analysis revealed an accumulation of the transduced cells in the G(0)/G(1) phase of the cell cycle. This BRCA1-mediated accumulation of cells in G(0)/G(1) was accompanied by an increase in the cellular level of hypophosphorylated pRB. Ad mutant BRCA1 t340, C61G, and 1853Stop viruses were impaired, to varying degrees, in their ability to transduce a growth-arrested state to the target cells. Using these same three criteria, overexpression of murine Brca1 by AdBrca1 was also capable of transducing a growth-arrested state to human cells. Deletion of the C-terminus of Brca1 diminished this activity. This panel of adenoviruses may be useful reagents as part of an approach to understand the function of BRCA1/Brca1 in normal breast and ovary and he Ip to define the tu mor suppressor defect (s) conferred by clinical BRCA1 mutations in breast and ovarian cell tumorigenesis.
C1 Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA.
   NCI, Sect Mol Signaling & Oncogenesis, Div Clin Sci, Bethesda, MD 20892 USA.
RP Campbell, M (reprint author), TVC 4912, Nashville, TN 37232 USA.
RI Liu, Edison/C-4141-2008; Jensen, Roy/B-9739-2011
OI Jensen, Roy/0000-0003-4430-2281
FU NCI NIH HHS [P30 CA68485, R29 CA62161, T32 CA09592-12]
NR 32
TC 5
Z9 5
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0929-1903
J9 CANCER GENE THER
JI Cancer Gene Ther.
PD MAR
PY 2001
VL 8
IS 3
BP 231
EP 239
DI 10.1038/sj.cgt.7700291
PG 9
WC Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity;
   Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity;
   Research & Experimental Medicine
GA 421UY
UT WOS:000168083000010
PM 11332994
ER

PT J
AU Renkvist, N
   Castelli, C
   Robbins, PF
   Parmiani, G
AF Renkvist, N
   Castelli, C
   Robbins, PF
   Parmiani, G
TI A listing of human tumor antigens recognized by T cells
SO CANCER IMMUNOLOGY IMMUNOTHERAPY
LA English
DT Review
DE antigens; tumor; T cells; epitopes
ID HUMAN-MELANOMA ANTIGEN; TYROSINASE-RELATED PROTEIN-2; IN-VITRO
   IMMUNIZATION; PULSED DENDRITIC CELLS; CHRONIC MYELOGENOUS LEUKEMIA;
   CYTOLYTIC LYMPHOCYTES-T; HUMAN BLADDER-CARCINOMA; OPEN READING FRAME;
   HUMAN GENE MAGE-3; HLA-DR MOLECULES
C1 Ist Nazl Tumori, Unit Immunotherapy Human Tumors, I-20133 Milan, Italy.
   NCI, Surg Branch, NIH, Bethesda, MD 20892 USA.
RP Parmiani, G (reprint author), Ist Nazl Tumori, Unit Immunotherapy Human Tumors, Via Venezian 1, I-20133 Milan, Italy.
RI castelli, chiara/K-6899-2012
OI castelli, chiara/0000-0001-6891-8350
NR 147
TC 334
Z9 352
U1 0
U2 12
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0340-7004
J9 CANCER IMMUNOL IMMUN
JI Cancer Immunol. Immunother.
PD MAR
PY 2001
VL 50
IS 1
BP 3
EP 15
DI 10.1007/s002620000169
PG 13
WC Oncology; Immunology
SC Oncology; Immunology
GA 413ZB
UT WOS:000167640500002
PM 11315507
ER

PT J
AU Schwartzentruber, DJ
AF Schwartzentruber, DJ
TI High-dose interleukin-2 is an intensive treatment regardless of the
   venue of administration
SO CANCER JOURNAL
LA English
DT Editorial Material
ID METASTATIC CANCER
C1 NCI, NIH, Bethesda, MD 20892 USA.
RP Schwartzentruber, DJ (reprint author), NCI, NIH, Bldg 10,Room 2B-04,10 Ctr Dr, Bethesda, MD 20892 USA.
NR 5
TC 8
Z9 8
U1 0
U2 2
PU JONES AND BARTLETT PUBLISHERS
PI SUDBURY
PA 40 TALL PONE DR, SUDBURY, MA 01776 USA
SN 1528-9117
J9 CANCER J
JI Cancer J. Sci. Am.
PD MAR-APR
PY 2001
VL 7
IS 2
BP 103
EP 104
PG 2
WC Oncology
SC Oncology
GA 419TX
UT WOS:000167965700004
PM 11324761
ER

PT J
AU Schrump, DS
   Nguyen, DM
AF Schrump, DS
   Nguyen, DM
TI The epidermal growth factor receptor - STAT pathway in esophageal cancer
SO CANCER JOURNAL
LA English
DT Editorial Material
ID SQUAMOUS-CELL CARCINOMA; PROGNOSTIC-SIGNIFICANCE; KINASE; EXPRESSION;
   LEVEL
C1 NCI, Thorac Oncol Sect, Surg Branch, NIH, Bethesda, MD 20892 USA.
RP Schrump, DS (reprint author), NCI, Thorac Oncol Sect, Surg Branch, NIH, Bldg 10,Room 2B-07,10 Ctr Dr, Bethesda, MD 20892 USA.
NR 21
TC 9
Z9 9
U1 0
U2 0
PU JONES AND BARTLETT PUBLISHERS
PI SUDBURY
PA 40 TALL PONE DR, SUDBURY, MA 01776 USA
SN 1528-9117
J9 CANCER J
JI Cancer J. Sci. Am.
PD MAR-APR
PY 2001
VL 7
IS 2
BP 108
EP 111
PG 4
WC Oncology
SC Oncology
GA 419TX
UT WOS:000167965700006
PM 11324763
ER

PT J
AU Donald, SP
   Sun, XY
   Hu, CAA
   Yu, J
   Mei, JM
   Valle, D
   Phang, JM
AF Donald, SP
   Sun, XY
   Hu, CAA
   Yu, J
   Mei, JM
   Valle, D
   Phang, JM
TI Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation
   of proline-dependent reactive oxygen species
SO CANCER RESEARCH
LA English
DT Article
ID PYRROLINE-5-CARBOXYLIC ACID; CLONING; DELTA-1-PYRROLINE-5-CARBOXYLATE;
   INTERCONVERSIONS; DEHYDROGENASE; MITOCHONDRIA; STIMULATION; APOPTOSIS;
   CELLS; CDNA
AB The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c, However, the contribution of increased POX activity to apoptosis, if any, remains unknown, Using Adriamycin to initiate p53-dependent apoptosis, we showed that the expression of POX is up-regulated in a time- and dose-dependent manner in a human colon cancer cell line (LoVo), In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect, Induction of POX was dependent on the p53 status of the cell. In the conditionally immortalized murine colonic epithelial cell line YAMC. where the p53 phenotype can be modulated by temperature, proline oxidase expression and ROS production could only be induced when the cells were phenotypically p53-positive. To confirm that the observed ROS production was not secondary to some other effect of p53, we also conditionally expressed POX in a p53-negative colon cancer line, Again, we found a proline-dependent ROS increase with POX expression, We hypothesize that proline oxidation supports the generation of KOS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX.
C1 NCI, Metab & Canc Susceptibil Sect, Basic Res Lab, Div Basic Sci, Frederick, MD 21702 USA.
   Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Pediat, Baltimore, MD 21231 USA.
   Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21231 USA.
   Johns Hopkins Univ, Grad Program Human Genet & Mol Biol, Baltimore, MD 21205 USA.
RP Phang, JM (reprint author), NCI, Metab & Canc Susceptibil Sect, Basic Res Lab, Div Basic Sci, Bldg 560,Room 12-90, Frederick, MD 21702 USA.
NR 28
TC 161
Z9 162
U1 0
U2 9
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 1810
EP 1815
PG 6
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100010
PM 11280728
ER

PT J
AU Urasaki, Y
   Laco, GS
   Pourquier, P
   Takebayashi, Y
   Kohlhagen, G
   Gioffre, C
   Zhang, HL
   Chatterjee, D
   Pantazis, P
   Pommier, Y
AF Urasaki, Y
   Laco, GS
   Pourquier, P
   Takebayashi, Y
   Kohlhagen, G
   Gioffre, C
   Zhang, HL
   Chatterjee, D
   Pantazis, P
   Pommier, Y
TI Characterization of a novel topoisomerase I mutation from a
   camptothecin-resistant human prostate cancer cell line
SO CANCER RESEARCH
LA English
DT Article
ID DIOL EPOXIDE ADDUCTS; CLEAVAGE COMPLEXES; POINT MUTATION; DNA CLEAVAGE;
   IDENTIFICATION; LEUKEMIA; INDUCTION; INHIBITORS; PHOSPHORYLATION;
   MECHANISMS
AB In this study, we characterized the structure and function of topoisomerase I (top1) protein in the camptothecin (CPT)-resistant prostate cancer cell lines, DU-145/RC0.1 and DU-145/RC1 (RC0.1 and RC1, respectively), Both of the cell lines were previously selected by continuous exposure to 9-nitro-CPT. The RC0.1 and RC1 cells have high cross-resistance to CPT derivatives including SN-38 and topotecan, but are not cross-resistant to the non-top1 inhibitors etoposide, doxorubicin, and vincristine. Although the top1 protein levels were not decreased in the resistant cells compared with the parental cells, CPT-induced DNA cleavage was markedly reduced in the RC0.1 and RC1 nuclear extracts. The resistant-cell-line nuclear extracts also demonstrated top1 catalytic activity and resistance to CPT, in in vitro assays. Reverse transcription-PCR products from the resistant cell lines were sequenced, and revealed a point mutation resulting in a R364H mutation in the top1 of both RC0.1 and RC1, No wild-type top1 RNA or genomic DNA was detected in the resistant cell lines. Using a purified recombinant R364H top1, we found that the R364H mutant top1 was CPT resistant and fully active. In the published top1 crystal structure, the R364H mutation is close to the catalytic tyrosine and other well-known mutations leading to CPT resistance.
C1 NCI, Mol Pharmacol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA.
   Tohoku Univ, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
   Brown Univ, Dept Mol Biol Cell Biol & Biochem, Dept Mol Biol, Div Biol & Med, Providence, RI 02912 USA.
RP Pommier, Y (reprint author), NCI, Mol Pharmacol Lab, Div Basic Sci, NIH, Bldg 37,Room 4E28,37 Convent Dr MSC 4255, Bethesda, MD 20892 USA.
NR 49
TC 75
Z9 80
U1 2
U2 4
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 1964
EP 1969
PG 6
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100035
PM 11280753
ER

PT J
AU Calvisi, DF
   Factor, VM
   Loi, R
   Thorgeirsson, SS
AF Calvisi, DF
   Factor, VM
   Loi, R
   Thorgeirsson, SS
TI Activation of beta-catenin during hepatocarcinogenesis in transgenic
   mouse models: Relationship to phenotype and tumor grade
SO CANCER RESEARCH
LA English
DT Article
ID HUMAN HEPATOCELLULAR CARCINOMAS; GROWTH-FACTOR-ALPHA; COMPARATIVE
   GENOMIC HYBRIDIZATION; EXPRESSING C-MYC; CYCLIN D1 GENE; CELL-LINES;
   NEOPLASTIC DEVELOPMENT; SIGNALING PATHWAYS; COLORECTAL-CANCER; B6C3F1
   MICE
AB Mutations affecting phosphorylation sites in the beta -catenin gene have been implicated in the development of human and rodent hepatocellular carcinomas (HCCs), Tn further investigate the involvement of this gene in hepatocarcinogenesis, we used several transgenic mouse models of hepatic tumors induced by overexpression of c-myc in the liver either alone or in combination with transforming growth factor (TGF) alpha or TGF-beta1. Activation of beta -catenin, as judged by the presence of mutations and/or nuclear translocation of the protein, was most frequent in liver tumors from c-myc (4/17; 23.5%) and c-myc/TGF-beta1 (6/18; 33.3%) transgenic mice. However, it was very rare in faster growing and histologically more aggressive HCCs developed in c-myc/TGF-alpha mice (1/20; 5%). Administration of diethylnitrosamine, phenobarbital, or 2-amino-3,8-diethylimidazo[4,5-f]quinoxaline did not significantly affect the occurrence of beta -catenin mutations. Notably, nuclear accumulation of beta -catenin was observed only in adenomas and highly differentiated carcinomas with eosinophilic phenotype, Furthermore, preneoplastic lesions with eosinophilic phenotype frequently displayed focal nuclear positivity, colocalized with areas of high proliferation. In contrast, basophilic and clear-cell foci, as well as pseudo-glandular and poorly differentiated HCCs, exhibited a normal or reduced membranous immunoreactivity for beta -catenin, These studies suggest that nuclear translocation of beta -catenin and activation of Wingless/Wnt signaling mag represent an early event in liver carcinogenesis, providing a growth advantage in a subset of hepatic tumors with a more differentiated phenotype.
C1 NCI, Expt Carcinogenesis Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA.
RP Thorgeirsson, SS (reprint author), NCI, Expt Carcinogenesis Lab, Div Basic Sci, NIH, Bldg 37,Room 3C28,37 Convent Dr MSC 4255, Bethesda, MD 20892 USA.
OI Loi, Roberto/0000-0003-2371-3874
NR 64
TC 73
Z9 83
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 2085
EP 2091
PG 7
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100052
PM 11280770
ER

PT J
AU Pihan, GA
   Purohit, A
   Wallace, J
   Malhotra, R
   Liotta, L
   Doxsey, SJ
AF Pihan, GA
   Purohit, A
   Wallace, J
   Malhotra, R
   Liotta, L
   Doxsey, SJ
TI Centrosome defects can account for cellular and genetic changes that
   characterize prostate cancer progression
SO CANCER RESEARCH
LA English
DT Article
ID SCANNING LASER MICROSCOPY; DNA IMAGE CYTOMETRY; GAMMA-TUBULIN;
   PERICENTRIN; INSTABILITY; PLOIDY; ADENOCARCINOMA; ORGANIZATION;
   NUCLEATION; SPECIMENS
AB Factors that determine the biological and clinical behavior of prostate cancer are largely unknown. Prostate tumor progression is characterized by changes in cellular architecture, glandular organization, and genomic composition. These features are reflected in the Gleason grade of the tumor and in the development of aneuploidy, Cellular architecture and genomic stability are controlled in part by centrosomes, organelles that organize microtubule arrays including mitotic spindles. Here we demonstrate that centrosomes are structurally and numerically abnormal in the majority of prostate carcinomas. Centrosome abnormalities increase with increasing Gleason grade and with increasing levels of genomic instability. Selective induction of centrosome abnormalities by elevating levels of the centrosome protein pericentrin in prostate epithelial cell lines reproduces many of the phenotypic characteristics of high-grade prostate carcinoma. Cells that transiently or permanently express pericentrin exhibit severe centrosome and spindle defects, cellular disorganization, genomic instability, and enhanced growth in soft agar, On the basis of these observations, we propose a model in which centrosome dysfunction contributes to the progressive loss of cellular and glandular architecture and increasing genomic instability that accompany prostate cancer progression, dissemination, and lethality.
C1 Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA.
   Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01655 USA.
   NCI, Dept Pathol, Bethesda, MD 20892 USA.
RP Pihan, GA (reprint author), Univ Massachusetts, Sch Med, Dept Pathol, Room S2-141,55 Lake Ave N, Worcester, MA 01655 USA.
FU NIGMS NIH HHS [R01 GM51994]
NR 47
TC 243
Z9 255
U1 0
U2 7
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 2212
EP 2219
PG 8
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100071
PM 11280789
ER

PT J
AU Hu, YJ
   Korotkov, KV
   Mehta, R
   Hatfield, DL
   Rotimi, CN
   Luke, A
   Prewitt, TE
   Cooper, RS
   Stock, W
   Vokes, EE
   Dolan, ME
   Gladyshev, VN
   Diamond, AM
AF Hu, YJ
   Korotkov, KV
   Mehta, R
   Hatfield, DL
   Rotimi, CN
   Luke, A
   Prewitt, TE
   Cooper, RS
   Stock, W
   Vokes, EE
   Dolan, ME
   Gladyshev, VN
   Diamond, AM
TI Distribution and functional consequences of nucleotide polymorphisms in
   the 3 '-untranslated region of the human Sep15 gene
SO CANCER RESEARCH
LA English
DT Article
ID TUMOR SUPPRESSOR GENES; SELENIUM STATUS; CANCER; SELENOCYSTEINE; RISK
AB Selenium has been shown to prevent cancer in a variety of animal model systems. Both epidemiological studies and supplementation trials have supported its efficacy in humans. However, the mechanism by which selenium suppresses tumor development remains unknown. Selenium is present in known human selenoproteins as the amino acid selenocysteine (Sec), Sec is inserted cotranslationally in response to UGA codons within selenoprotein mRNAs in a process requiring a sequence within the 3'-untranslated region (UTR), referred to as a Sec insertion sequence (SECIS) element. Recently, a human M-r 15,000 selenoprotein (Sep15) was identified that contains an in-frame UGA codon and a SECIS element in the 3'-UTR, Examination of the available cDNA sequences for this protein revealed two polymorphisms located at position 811 (C/T) and at position 1125 (G/A) located within the 3'-UTR, Here, we demonstrate significant differences in Sep15 allele frequencies by ethnicity and that the identity of the nucleotides at the polymorphic sites influences SECIS function in a selenium-dependent manner. This, together with genetic data indicating loss of heterozygosity at the Sep15 locus in certain human tumor types. suggests that Sep15 may be involved in cancer development. risk, or both.
C1 Univ Illinois, Dept Human Nutr & Dietet, Chicago, IL 60612 USA.
   Univ Illinois, Dept Surg Oncol, Chicago, IL 60612 USA.
   Univ Illinois, Dept Hematol Oncol, Chicago, IL 60612 USA.
   Univ Nebraska, Dept Biochem, Beadle Ctr, Lincoln, NE 68588 USA.
   NCI, Sect Mol Biol Selenium, Basic Res Lab, NIH, Bethesda, MD 20892 USA.
   Howard Univ, Dept Genet Epidemiol, Natl Human Genome Ctr, Washington, DC 20059 USA.
   Loyola Univ, Stritch Sch Med, Dept Epidemiol & Prevent Med, Maywood, IL 60153 USA.
   Univ Chicago, Dept Med, Chicago, IL 60637 USA.
RP Gladyshev, VN (reprint author), Univ Illinois, Dept Human Nutr & Dietet, Chicago, IL 60612 USA.
RI Gladyshev, Vadim/A-9894-2013
FU PHS HHS [11921]
NR 18
TC 86
Z9 88
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 2307
EP 2310
PG 4
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100085
PM 11280803
ER

PT J
AU Hartsough, MT
   Clare, SE
   Mair, M
   Elkahloun, AG
   Sgroi, D
   Osborne, CK
   Clark, G
   Steeg, PS
AF Hartsough, MT
   Clare, SE
   Mair, M
   Elkahloun, AG
   Sgroi, D
   Osborne, CK
   Clark, G
   Steeg, PS
TI Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene
   expression and reduced motility by DNA methylation inhibition
SO CANCER RESEARCH
LA English
DT Article
ID NM23/NUCLEOSIDE DIPHOSPHATE KINASE; TISSUE GROWTH-FACTOR; CANCER
   CELL-LINE; MELANOMA-CELLS; RETINOIC ACID; ESTROGEN-RECEPTOR;
   BASEMENT-MEMBRANE; PROSTATE-CANCER; CPG ISLANDS; IN-VIVO
AB We hypothesize that elevation of Nm23-H1 expression in micrometastatic breast cancer cells may inhibit their metastatic colonization and further invasion, and induce differentiation, thus resulting in a clinical benefit. The current study investigated the possible contribution of DNA methylation to the regulation of Nm23-H1 expression, based on the observation that two CpG. islands are present in its promoter. 5-Aza-2'-deoxycytidine (5-Aza-CdR), a DNA methylation inhibitor, increased the Nm23-H1 expression of 5 of 11 human breast carcinoma cell lines in vitro, including 3 of 3 metastatically competent lines. Increased Nm23-H1 expression was accompanied by a reduction in motility in vitro, with minimal effect on proliferation. Both increased Nm23-H1 expression and decreased motility were observed using low (75 nM) concentrations of 5-Aza-CdR, Array analysis of MDA-MB-231 breast carcinoma cells treated with 5-Aza-CdR confirmed the elevation of nm23-H1 mRNA, whereas relatively few other genes exhibited altered expression, Bisulfite sequencing of the two CpG islands in a panel of cell lines and in 20 infiltrating ductal carcinomas revealed that one island (-3090 bp to -3922 bp) exhibited infrequent differential methylation. The data indicate that DNA methylation inhibitors ran directly or indirectly cause both elevation of Nm23-H1 expression and decreased function in one aspect of metastasis, motility.
C1 NCI, NIH, Womens Canc Sect, Pathol Lab,Div Clin Sci, Bethesda, MD 20892 USA.
   Massachusetts Gen Hosp, Dept Mol Pathol, Charlestown, MA 02129 USA.
   Baylor Coll Med, Breast Ctr, Houston, TX 77030 USA.
   NHGRI, Canc Genet Branch, Bethesda, MD 20892 USA.
RP Hartsough, MT (reprint author), NCI, NIH, Womens Canc Sect, Pathol Lab,Div Clin Sci, Bldg 10,Room 2A33, Bethesda, MD 20892 USA.
NR 70
TC 67
Z9 77
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2001
VL 61
IS 5
BP 2320
EP 2327
PG 8
WC Oncology
SC Oncology
GA 412RL
UT WOS:000167568100087
PM 11280805
ER

PT J
AU D'Agostini, F
   Balansky, RM
   Izzotti, A
   Lubet, RA
   Kelloff, GJ
   De Flora, S
AF D'Agostini, F
   Balansky, RM
   Izzotti, A
   Lubet, RA
   Kelloff, GJ
   De Flora, S
TI Modulation of apoptosis by cigarette smoke and cancer chemopreventive
   agents in the respiratory tract of rats
SO CARCINOGENESIS
LA English
DT Article
ID CELL-DEATH; N-ACETYLCYSTEINE; TOBACCO-SMOKE; DNA-ADDUCTS; ANTIOXIDANTS;
   CARCINOGENESIS; PROLIFERATION; PROTECTION; MECHANISMS; INDUCTION
AB Preclinical studies may elucidate the meaning of biomarkers applicable to epidemiologic studies and to clinical trials for cancer prevention. No study has explored so far the effect of cigarette smoke on apoptosis in vivo. We evaluated modulation of apoptosis in cells of the respiratory tract of smoke-exposed Sprague-Dawley rats both by morphological analysis and TUNEL method. In a first study, exposure of rats to mainstream cigarette smoke for either 18 or 100 consecutive days produced a significant and time-dependent increase in the proportion of apoptotic cells in the bronchial and bronchiolar epithelium. Oral N-acetylcysteine did not affect the background frequency of apoptosis but significantly and sharply decreased smoke-induced apoptosis, In a second study, exposure of rats to a mixture of sidestream and mainstream smoke for 28 consecutive days resulted in a >10-fold increase in the frequency of pulmonary alveolar macrophages undergoing apoptosis, Dietary administration of either 5,6-benzoflavone, 1,2-dithiole-3-thione or oltipraz did not affect the frequency of smoke-induced apoptosis, whereas phenethyl isothiocyanate produced a further significant enhancement. Again, N-acetylcysteine and its combination with oltipraz significantly decreased smoke-induced apoptosis, In both studies exposure to smoke resulted in a sharp increase of cells positive for proliferating cell nuclear antigen (PCNA), which was unaffected by the examined chemopreventive agents, These findings highlight the concept that modulation of apoptosis has diversified meanings. Different meanings (as explained in the following lines). First, the apoptotic process is triggered as a defense system against genotoxic agents, such as the components of cigarette smoke. The further induction produced by phenethyl isothiocyanate, favoring removal of damaged cells, represents an example of a detoxification mechanism. Inhibition of smoke-induced apoptosis by N-acetylcysteine should be interpreted as an epiphenomenon of antigenotoxic mechanisms, as shown in parallel studies evaluating modulation of DNA alterations in the respiratory tract of the same animals. Thus, it is important to discriminate between whether the opposite modulation of apoptosis is per se a protective mechanism or the beneficial outcome of other mechanisms inhibiting genotoxicity.
C1 Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy.
   NCI, Rockville, MD 20892 USA.
RP De Flora, S (reprint author), Univ Genoa, Dept Hlth Sci, Via A Pastore 1, I-16132 Genoa, Italy.
OI izzotti, alberto/0000-0002-8588-0347
FU NCI NIH HHS [N01-CN-75008]
NR 32
TC 75
Z9 78
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0143-3334
J9 CARCINOGENESIS
JI Carcinogenesis
PD MAR
PY 2001
VL 22
IS 3
BP 375
EP 380
DI 10.1093/carcin/22.3.375
PG 6
WC Oncology
SC Oncology
GA 410NX
UT WOS:000167447000002
PM 11238175
ER

PT J
AU Sei, Y
   Gallagher, KL
   Daly, JW
AF Sei, Y
   Gallagher, KL
   Daly, JW
TI Multiple effects of caffeine on Ca2+ release and influx in human B
   lymphocytes
SO CELL CALCIUM
LA English
DT Article
ID SMOOTH-MUSCLE CELLS; RYANODINE RECEPTOR; INOSITOL TRISPHOSPHATE;
   SURFACE-IMMUNOGLOBULIN; SARCOPLASMIC-RETICULUM; INTRACELLULAR CALCIUM;
   PLASMA-MEMBRANE; CA-2+ RELEASE; CHANNEL; ACTIVATION
AB Caffeine has been used as a pharmacological tool to study the ryanodine receptor (RYR)-mediated Ca2+ release from caffeine-sensitive, inositol 1,4,5,-trisphosphate (IP3)-insensitive pools. In the present study, we demonstrate multiple effects of caffeine on Ca2+ homeostasis in human B lymphocytes. Although B cells express a functional RYR, which can be activated by 4-chloro-m-cresol following depletion of IP3-sensitive pools, caffeine does not activate RYR-mediated Ca2+ release. Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (>25mM) induced a Ca2+ influx. In contrast with its ability to suppress receptor-stimulated Ca2+ influx, caffeine had no significant effect on the store-operated Ca2+ (SOC) channel-dependent Ca2+ influx induced by thapsigargin. Thus, caffeine may act as an inhibitor on a single or multiple site(s) responsible for regulating the IP3R channel, RYR channel and presumably the receptor-mediated SOC channel. The present report may be the first demonstration of multiple effects of caffeine on Ca2+ mobilization in single cell type. Our results suggest the need for caution regarding use of caffeine simply as a RYR-activator to study Ca2+ homeostasis in eucaryotic cells. (C) 2001 Harcourt Publishers Ltd.
C1 Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA.
   NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Sei, Y (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
NR 38
TC 28
Z9 29
U1 1
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4160
J9 CELL CALCIUM
JI Cell Calcium
PD MAR
PY 2001
VL 29
IS 3
BP 149
EP 160
DI 10.1054/ceca.2000.0175
PG 12
WC Cell Biology
SC Cell Biology
GA 405WY
UT WOS:000167184600001
PM 11162852
ER

PT J
AU Hsia, SCV
   Wang, H
   Shi, YB
AF Hsia, SCV
   Wang, H
   Shi, YB
TI Involvement of chromatin and histone acetylation in the regulation of
   HIV-LTR by thyroid hormone receptor
SO CELL RESEARCH
LA English
DT Article
DE HIV; thyroid hormone receptor; histone acetylation; transcriptional
   repression; Xenopus oocyte
ID LONG TERMINAL REPEAT; TRANSCRIPTIONAL ACTIVATION; MOLECULAR MECHANISMS;
   RESPONSE ELEMENT; GENE-REGULATION; XENOPUS-LAEVIS; SUPERFAMILY
AB The HTV-1 LTR controls the expression of HIV-1 viral genes and thus is critical for viral propagation and pathology. Numerous host factors have been shown to participate in the regulation of the LTR promoter. Among them is the thyroid hormone (T-3) receptor (TR). TR has been shown to bind to the critical region of the promoter that contain the NF kappaB and Sp1 binding sites. Interestingly, earlier transient transfection studies in tissue culture cells have yielded contradicting conclusions on the role of TR in LTR regulation, likely due to the use of different cell types and/or lack of proper chromatin organization. Here, using the frog oocyte as a model system that allows replication-coupled chromatin assembly, mimicking that in somatic cells, we demonstrate that unliganded heterodimers of TR and RXR (9-cis retinoic acid receptor) repress LTR while the addition of T-3 relieves the repression and further activates the promoter. More importantly, we show that chromatin and unliganded TR/RXR synergize to repress the promoter in a histone deacetylase-dependent manner.
C1 NICHHD, Unit Mol Morphogenesis, Mol Embryol Lab, NIH, Bethesda, MD 20892 USA.
RP Shi, YB (reprint author), NICHHD, Unit Mol Morphogenesis, Mol Embryol Lab, NIH, Bldg 18T,Room 106, Bethesda, MD 20892 USA.
RI Wang, Hua/E-4269-2011
NR 29
TC 17
Z9 18
U1 0
U2 0
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1001-0602
J9 CELL RES
JI Cell Res.
PD MAR
PY 2001
VL 11
IS 1
BP 8
EP 16
DI 10.1038/sj.cr.7290061
PG 9
WC Cell Biology
SC Cell Biology
GA 418QA
UT WOS:000167901800002
PM 11305329
ER

PT J
AU Wolf, K
   Hackstadt, T
AF Wolf, K
   Hackstadt, T
TI Sphingomyelin trafficking in Chlamydia pneumoniae-infected cells
SO CELLULAR MICROBIOLOGY
LA English
DT Article
ID INCLUSION MEMBRANE; GOLGI-APPARATUS; PHYSICAL-PROPERTIES; ENDOCYTIC
   PATHWAY; BREFELDIN-A; HOST-CELLS; TRACHOMATIS; PROTEINS; TRANSPORT;
   PSITTACI
AB Chlamydia pneumoniae is a bacterial obligate intracellular parasite with a developmental cycle common to all members of the genus Chlamydia, Like other chlamydiae, the developmental cycle of C. pneumoniae occurs entirely within a membrane-bound intracellular vacuole, termed an inclusion, that is non-fusogenic with endosomal or lysosomal compartments. To characterize the vesicular interactions of the C. pneumoniae inclusion, we used a fluorescent analogue of ceramide, (N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine (C-6-NBD-Cer), that has previously been used to characterize the endogenous synthesis and transport of sphingolipids from the Golgi apparatus to Chlamydia trachomatis and Chlamydia psittaci inclusions. Sphingolipids are trafficked to C. pneumoniae inclusions in a time-, temperature- and energy-dependent manner with properties very similar to the delivery of sphingomyelin to C. trachomatis inclusions. These results indicate that interactions of the inclusion with a subset of sphingomyelin-containing exocytic vesicles is a property common to all species of chlamydiae.
C1 NIAID, Host Parasite Interact Sect, Intracellular Parasites Lab, Rocky Mt Labs, Hamilton, MT 59840 USA.
RP Hackstadt, T (reprint author), NIAID, Host Parasite Interact Sect, Intracellular Parasites Lab, Rocky Mt Labs, Hamilton, MT 59840 USA.
NR 39
TC 55
Z9 55
U1 0
U2 1
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 1462-5814
J9 CELL MICROBIOL
JI Cell Microbiol.
PD MAR
PY 2001
VL 3
IS 3
BP 145
EP 152
DI 10.1046/j.1462-5822.2001.00098.x
PG 8
WC Cell Biology; Microbiology
SC Cell Biology; Microbiology
GA 417GZ
UT WOS:000167828200003
PM 11260137
ER

PT J
AU Shears, SB
AF Shears, SB
TI Assessing the omnipotence of inositol hexakisphosphate
SO CELLULAR SIGNALLING
LA English
DT Review
DE inositol hexakisphosphate; phytic acid; signal transduction; inositol
   phosphates; calcium; magnesium
ID HIGH-AFFINITY BINDING; PHYTIC ACID; PLASMA-MEMBRANE; MYOINOSITOL
   HEXAKISPHOSPHATE; POLYPHOSPHATE PHOSPHATASE; PHOSPHOINOSITIDE BINDING;
   SACCHAROMYCES-CEREVISIAE; PANCREATOMA CELLS; C2B DOMAIN; IN-VITRO
AB This review assesses the authenticity of inositol hexakisphosphate (InsP(6)) being a wide-ranging regulator of many important cellular functions. Against a background in which the possible importance of localized InsP(6) metabolism is discussed. there is the facile explanation that InsP(6) is merely an "inactive" precursor for the diphosphorylated inositol phosphates. Indeed. many of the proposed cellular functions of InsP(6) cannot sustain a challenge from the implementation of a rigorous set of criteria. which are designed to avoid experimental artefacts. Published by Elsevier Science Inc.
C1 NIEHS, Inositol Signaling Sect, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA.
RP Shears, SB (reprint author), NIEHS, Inositol Signaling Sect, Lab Signal Transduct, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM shears@nichs.nih.gov
NR 93
TC 118
Z9 120
U1 4
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0898-6568
J9 CELL SIGNAL
JI Cell. Signal.
PD MAR
PY 2001
VL 13
IS 3
BP 151
EP 158
DI 10.1016/S0898-6568(01)00129-2
PG 8
WC Cell Biology
SC Cell Biology
GA 419DF
UT WOS:000167933500001
PM 11282453
ER

PT J
AU Xu, B
   Grafman, J
   Gaillard, WD
   Ishii, K
   Vega-Bermudez, F
   Pietrini, P
   Reeves-Tyer, P
   DiCamillo, P
   Theodore, W
AF Xu, B
   Grafman, J
   Gaillard, WD
   Ishii, K
   Vega-Bermudez, F
   Pietrini, P
   Reeves-Tyer, P
   DiCamillo, P
   Theodore, W
TI Conjoint and extended neural networks for the computation of speech
   codes: The neural basis of selective impairment in reading words and
   pseudowords
SO CEREBRAL CORTEX
LA English
DT Article
ID LEFT PREFRONTAL CORTEX; VISUAL WORKING-MEMORY; PHONOLOGICAL AGRAPHIA;
   STRATEGIC CONTROL; HUMAN-BRAIN; SHALLOW ORTHOGRAPHY; SEMANTIC MEMORY;
   FUNCTIONAL MRI; LEXICAL ACCESS; BLOOD-FLOW
AB The computation of speech codes (i.e, phonology) is an important aspect of word reading. Understanding the neural systems and mechanisms underlying phonological processes provides a foundation for the investigation of language in the brain. We used high-resolution three-dimensional positron emission tomography (PET) to investigate neural systems essential for phonological processes. The burden of neural activities on the computation of speech codes was maximized by three rhyming tasks (rhyming words, pseudowords and words printed in mixed letter cases). Brain activation patterns associated with these tasks were compared with those of two baseline tasks involving visual feature detection. Results suggest strong left lateralized epicenters of neural activity in rhyming irrespective of gender. Word rhyming activated the same brain regions engaged in pseudoword rhyming, suggesting conjoint neural networks for phonological processing of words and pseudowords. However, pseudoword rhyming induced the largest change in cerebral blood flow and activated more voxels in the left posterior prefrontal regions and the left inferior occipital-temporal junction. In addition, pseudoword rhyming activated the left supramarginal gyrus, which was not apparent in word rhyming. These results suggest that rhyming pseudowords requires active participation of extended neural systems and networks not observed for rhyming words, The implications of the results on theories and models of visual word reading and on selective reading dysfunctions after brain lesions are discussed.
C1 NINDS, Epilepsy Res Branch, NIH, Bethesda, MD 20892 USA.
   NINDS, Cognit Neurosci Sect, NIH, Bethesda, MD 20892 USA.
   Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA.
RP Xu, B (reprint author), NINDS, Epilepsy Res Branch, NIH, 5N 250 Bldg 10 Ctr Dr, Bethesda, MD 20892 USA.
EM xub@ninds.nih.gov
OI Grafman, Jordan H./0000-0001-8645-4457
NR 92
TC 150
Z9 152
U1 3
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
J9 CEREB CORTEX
JI Cereb. Cortex
PD MAR
PY 2001
VL 11
IS 3
BP 267
EP 277
DI 10.1093/cercor/11.3.267
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 407TD
UT WOS:000167286100008
PM 11230098
ER

PT J
AU Kohn, KW
AF Kohn, KW
TI Molecular interaction maps as information organizers and simulation
   guides
SO CHAOS
LA English
DT Article
ID SIGNAL-TRANSDUCTION; PHOSPHOINOSITIDE 3-KINASE; REPRESS TRANSCRIPTION;
   HISTONE DEACETYLASE; TYROSINE KINASES; SRC; E2F; ACTIVATION; MECHANISM;
   PROTEINS
AB A graphical method for mapping bioregulatory networks is presented that is suited for the representation of multimolecular complexes, protein modifications, as well as actions at cell membranes and between protein domains. The symbol conventions defined for these molecular interaction maps are designed to accommodate multiprotein assemblies and protein modifications that can generate combinatorially large numbers of molecular species. Diagrams can either be "heuristic," meaning that detailed knowledge of all possible reaction paths is not required, or "explicit," meaning that the diagrams are totally unambiguous and suitable for simulation. Interaction maps are linked to annotation lists and indexes that provide ready access to pertinent data and references, and that allow any molecular species to be easily located. Illustrative interaction maps are included on the domain interactions of Src, transcription control of E2F-regulated genes, and signaling from receptor tyrosine kinase through phosphoinositides to Akt/PKB. A simple method of going from an explicit interaction diagram to an input file for a simulation program is outlined, in which the differential equations need not be written out. The role of interaction maps in selecting and defining systems for modeling is discussed. (C) 2001 American Institute of Physics.
C1 NCI, Mol Pharmacol Lab, Div Basic Sci, Bethesda, MD 20892 USA.
RP Kohn, KW (reprint author), NCI, Mol Pharmacol Lab, Div Basic Sci, Bethesda, MD 20892 USA.
NR 46
TC 48
Z9 49
U1 0
U2 0
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 1054-1500
J9 CHAOS
JI Chaos
PD MAR
PY 2001
VL 11
IS 1
BP 84
EP 97
DI 10.1063/1.1338126
PG 14
WC Mathematics, Applied; Physics, Mathematical
SC Mathematics; Physics
GA 407ZJ
UT WOS:000167301400009
ER

PT J
AU Orbach, Y
   Lamb, ME
AF Orbach, Y
   Lamb, ME
TI The relationship between within-interview contradictions and eliciting
   interviewer utterances
SO CHILD ABUSE & NEGLECT
LA English
DT Article
DE investigative interviews; contradictions; accuracy; suggestive
   questions; open-ended questions
ID EYEWITNESS TESTIMONY; CHILDRENS MEMORY; QUESTION REPETITION;
   PRESCHOOL-CHILDREN; REPEATED EXPOSURE; SUGGESTIBILITY; EVENT;
   SUGGESTIONS; STRESSFUL; ACCURACY
AB Objective: To determine whether interview practices associated with inaccurate reporting in laboratory analog contexts were also associated with inaccurate information in actual forensic contexts.
   Method: The forensic interview of a 5-year-old girl, an alleged victim of sexual abuse, was analyzed to explore interview practices associated with the retrieval of contradictory information. Content analyses of the child's responses focused on: (1) new informative details about the reported incidents; (2) contradictory details; (3) "central" and "peripheral" details; and (4) the types of utterances used to elicit each detail.
   Results: The results illustrate how risky option-posing and suggestive utterances can be, as most (90%) contradicting details were elicited using option-posing and suggestive utterances and almost all (98%) of the contradicted and contradicting details were central, containing crucial information concerning the investigated allegation. No contradictory details were elicited in response to open-ended invitations.
   Conclusion: The findings demonstrate that poor interviewing practices can be associated with high levels of internal contradiction and should be avoided by forensic interviewers. To avoid contaminating children's reports and increase the likely accuracy of the information retrieved, moreover, interviewers should elicit as much information as possible using open-ended utterances, which tap free-recall memory. (C) 2001 Elsevier Science Ltd. All rights reserved.
C1 NICHHD, Sect Social & Emot Dev, Bethesda, MD 20892 USA.
RP Lamb, ME (reprint author), NICHHD, Sect Social & Emot Dev, BSA Bldg,Room 331, Bethesda, MD 20892 USA.
NR 53
TC 52
Z9 52
U1 2
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0145-2134
J9 CHILD ABUSE NEGLECT
JI Child Abuse Negl.
PD MAR
PY 2001
VL 25
IS 3
BP 323
EP 333
DI 10.1016/S0145-2134(00)00254-4
PG 11
WC Family Studies; Psychology, Social; Social Work
SC Family Studies; Psychology; Social Work
GA 415LJ
UT WOS:000167722800001
PM 11414392
ER

PT J
AU Rogers, AS
   Ellenberg, JH
   Douglas, SD
   Henry-Reid, L
   Peralta, L
   Wilson, CM
AF Rogers, AS
   Ellenberg, JH
   Douglas, SD
   Henry-Reid, L
   Peralta, L
   Wilson, CM
CA Adolescent Med HIV AIDS Res Networ
TI Performance of antigens used in detecting delayed-type hypersensitivity
   in adolescents infected with the human immunodeficiency virus
SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
LA English
DT Article
ID SKIN-TEST ANERGY; HIV-INFECTION; TUBERCULIN POSITIVITY;
   CONFIDENCE-INTERVALS; IN-VITRO; PREVALENCE; RISK; PROGRESSION; WOMEN
AB We examined the performance of delayed-type hypersensitivity (DTH) antigens employing a new Candida albicans product in a human immunodeficiency virus (HIV)-infected and nonanergic adolescent population. Diameters of induration (in millimeters) for three intradermally applied antigens (C. albicans, tetanus toxoid, and mumps) were compared in a population of HIV-infected 12 to 18 year olds at study entry in a national multicenter study of HIV disease progression. CD4(+) T-cell counts mere measured in quality-controlled laboratories. The influence of past immunization, gender, and clinical status on antigen reactivity was evaluated with contingency table comparisons and relative risk estimation. Nearly one-half of the 123 eligible subjects were untreated, and almost three quarters were early in HIV disease by clinical indicators. There was no statistically significant difference in reactivity by past immunization status. Candida antigen (CASTA; Greer Laboratories) evoked DTH response in a significantly higher number of males and females at every level of induration (largest P value, 0.049 for male comparisons; all P values, <0.001 for females) and in subjects with early and intermediate HIV disease at every level of induration (all P values, <0.0001) than either tetanus or mumps antigens. No two-antigen combination was as useful as all three antigens across either gender or clinical categories, although candida and tetanus was the mast useful two-antigen combination at indurations of <3 mm. The superior performance of a new C. albicans antigen may extend the utility of DTH assessment in monitoring immune function.
C1 NICHHD, Pediat Adolescent & Maternal AIDS Branch, Bethesda, MD 20892 USA.
   Univ Maryland, Dept Pediat, Baltimore, MD 21201 USA.
   Univ Penn, Childrens Hosp, Dept Pediat, Philadelphia, PA 19104 USA.
   Cook Cty Hosp, Div Adolescent Med, Chicago, IL 60612 USA.
   Univ Alabama, Dept Geog Med, Birmingham, AL USA.
RP Rogers, AS (reprint author), NICHD, CRMC, PAMAB, 6100 Execut Blvd,Room 4B11 MSC 7510, Bethesda, MD 20892 USA.
NR 26
TC 6
Z9 6
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1071-412X
J9 CLIN DIAGN LAB IMMUN
JI Clin. Diagn. Lab. Immunol.
PD MAR
PY 2001
VL 8
IS 2
BP 273
EP 278
DI 10.1128/CDLI.8.2.273-278.2001
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 409FF
UT WOS:000167373300010
PM 11238207
ER

PT J
AU Kuhn, L
   Meddows-Taylor, S
   Gray, G
   Trabattoni, D
   Clerici, M
   Shearer, GM
   Tiemessen, C
AF Kuhn, L
   Meddows-Taylor, S
   Gray, G
   Trabattoni, D
   Clerici, M
   Shearer, GM
   Tiemessen, C
TI Reduced HIV-stimulated T-helper cell reactivity in cord blood with
   short-course antiretroviral treatment for prevention of maternal-infant
   transmission
SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY
LA English
DT Article
DE human immunodeficiency virus; cellular immunity; interleukin-2;
   antiretroviral treatment; maternal-infant transmission
ID IMMUNODEFICIENCY-VIRUS TYPE-1; HEALTH-CARE WORKERS; SEROPOSITIVE
   INDIVIDUALS; LYMPHOCYTE RESPONSES; INFECTED CHILDREN; PERIPHERAL-BLOOD;
   IMMUNE-RESPONSE; ORAL ZIDOVUDINE; COTE-DIVOIRE; ENVELOPE
AB T-helper cell responses to HIV have been associated with protection against maternal-infant HIV transmission in the absence of antiretroviral treatment, but the effects of antiretroviral treatment, now widely used for prevention, on development of these cell-mediated responses is unknown. We tested whether development of T-helper cell responses to HIV and other antigens would be affected by exposure to short-course regimens of zidovudine-lamivudine (ZDV-3TC) given to prevent maternal-infant HIV transmission. Cord blood samples were collected from 41 infants of HIV-infected mothers enrolled in a clinical trial in which they were treated with regimens of ZDV-3TC and from 29 infants whose HIV-infected mothers were not treated with any antiretroviral drugs. T-helper cell reactivity to HIV envelope peptides and other antigens was measured in vitro using a sensitive culture supernatant titration assay based on IL-2-dependent proliferation. Infants in the clinical trial were followed to 18 months to determine their HIV infection status, and venous blood samples were re-tested at 4.5 and 9 months for T-cell reactivity to HIV. HIV-stimulated T-helper cell reactivity in cord blood was detected 10-fold less frequently among those exposed to antiretroviral prophylaxis (2.4%) than among those unexposed (24.1%) (P = 0.007). Reductions in HIV-stimulated responses in cord blood occurred despite detectable HIV RNA (mean 3.38 standard deviation 0.76 log(10) copies per ml) at delivery among treated women and occurred independent of treatment duration. Our results suggest that short-course antiretroviral treatment given to prevent maternal-infant HIV transmission may attenuate HIV-stimulated T-cell memory responses in the neonate.
C1 Columbia Univ, Gertrude H Sergievsky Ctr, Coll Phys & Surg, Joseph L Mailman Sch Publ Hlth,Div Epidemiol, New York, NY 10032 USA.
   Natl Inst Virol, AIDS Virus Res Unit, Johannesburg, South Africa.
   Chris Hani Baragwanath Hosp, Perinatal HIV Res Unit, Soweto, South Africa.
   Univ Milan, Cattedra Immunol, Milan, Italy.
   NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
RP Kuhn, L (reprint author), Columbia Univ, Gertrude H Sergievsky Ctr, Coll Phys & Surg, Joseph L Mailman Sch Publ Hlth,Div Epidemiol, 630 W 168th St, New York, NY 10032 USA.
RI Trabattoni, Daria/G-7424-2012; Meddows-Taylor, Stephen/F-7699-2014
OI Meddows-Taylor, Stephen/0000-0002-9815-8097
FU FIC NIH HHS [TW00231]; NICHD NIH HHS [HD36177]
NR 45
TC 13
Z9 13
U1 0
U2 2
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0009-9104
J9 CLIN EXP IMMUNOL
JI Clin. Exp. Immunol.
PD MAR
PY 2001
VL 123
IS 3
BP 443
EP 450
DI 10.1046/j.1365-2249.2001.01460.x
PG 8
WC Immunology
SC Immunology
GA 431YX
UT WOS:000168660300015
PM 11298132
ER

PT J
AU Harpole, DH
   Moore, MB
   Herndon, JE
   Aloia, T
   D'Amico, TA
   Sporn, T
   Parr, A
   Linoila, I
   Allegra, C
AF Harpole, DH
   Moore, MB
   Herndon, JE
   Aloia, T
   D'Amico, TA
   Sporn, T
   Parr, A
   Linoila, I
   Allegra, C
TI The prognostic value of molecular marker analysis in patients treated
   with trimodality therapy for esophageal cancer
SO CLINICAL CANCER RESEARCH
LA English
DT Article
ID DNA MISMATCH REPAIR; THYMIDYLATE SYNTHASE; CISPLATIN RESISTANCE;
   COLORECTAL-CANCER; EXPRESSION; CARCINOMA; CHEMORADIOTHERAPY;
   ADENOCARCINOMA; CHEMOTHERAPY; SURGERY
AB The purpose of this study was to define the prognostic value of a group of molecular tumor markers in a well-staged population of patients treated with trimodality therapy for esophageal cancer. The original pretreatment paraffin-embedded endoscopic esophageal tumor biopsy material was obtained from 118 patients treated with concurrent cisplatin + 5-fluorouracil (5-FU) + 45 Gy radiation followed by resection from 1986 until 1997 at the Duke University Comprehensive Cancer Center. Three markers of possible platinum chemotherapy association [metallothionein (MT), glutathione S-transferase-pi (GST-pi), P-glycoprotein (P-gp or multidrug resistance)] and one marker of possible 5-FU association [thymidylate synthase (TS)] were measured using immunohistochemistry. The median cancer-free survival was 25.0 months, with a significantly improved survival for the 38 patients who had a complete response (P < 0.001), High-level expression of GST-<pi>, P-gp, and TS were associated with a decreased survival. MT was not significant in this population, Multivariate analysis identified high-level expression in two of the platinum markers (GST-pi and P-gp) and the 5-FU marker TS as independent predictors of early recurrence and death, In conclusion, this investigation measured three possible markers associated with platinum and one possible marker associated with 5-FU in a cohort of esophageal cancer patients. Independent prognostic significance was observed, which suggests that it may be possible to predict which patients may benefit most from trimodality therapy. These data heed to he reproduced in a prospective investigation.
C1 Duke Univ, Med Ctr, Thorac Oncol Program, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Div Canc Biostat, Durham, NC 27710 USA.
   NCI, NIH, Bethesda, MD 20892 USA.
RP Harpole, DH (reprint author), Duke Univ, Med Ctr, Thorac Oncol Program, DUMC Box 3617, Durham, NC 27710 USA.
NR 25
TC 51
Z9 52
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 1078-0432
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD MAR
PY 2001
VL 7
IS 3
BP 562
EP 569
PG 8
WC Oncology
SC Oncology
GA 418GT
UT WOS:000167883100018
PM 11297249
ER

PT J
AU Mertins, SD
   Myers, TG
   Hollingshead, M
   Dykes, D
   Bodde, E
   Tsai, P
   Jefferis, CA
   Gupta, R
   Linehan, WM
   Alley, M
   Bates, SE
AF Mertins, SD
   Myers, TG
   Hollingshead, M
   Dykes, D
   Bodde, E
   Tsai, P
   Jefferis, CA
   Gupta, R
   Linehan, WM
   Alley, M
   Bates, SE
TI Screening for and identification of novel agents directed at renal cell
   carcinoma
SO CLINICAL CANCER RESEARCH
LA English
DT Article
ID ANTICANCER DRUG SCREEN; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR GENE;
   PROTEIN-KINASE-C; QUATERNIZED ELLIPTICINES; MULTIDRUG-RESISTANCE;
   CANCER-CELLS; LINES; EXPRESSION; INHIBITORS
AB We were interested in identifying novel agents for renal cell carcinoma (RCC) by screening for activities that model renal tumor biology, Searching for relative renal cell sensitivity and leukemia insensitivity among cytotoxicity profiles in the NCI Drug Screen database, we identified 16 potential agents with renal selectivity. We evaluated the agents in 10 RCC cell lines (of primary and metastatic origin) isolated from 5 patients. The 50% inhibitory concentrations (IC,,) in these cell lines ranged from 0.019 +/- 0.013 to 11.4 +/- 0.55 muM and were comparable with values obtained with renal cell lines in the NCI Drug Screen panel. Because RCC are slowly growing tumors, we evaluated the compounds on rapidly (27% S phase) or slowly (6% S phase) growing cells. In contrast to doxorubicin, where cytotoxicity was restricted to rapidly proliferating cells, three compounds (NSC 280074, 281613, and 281817) were more cytotoxic in slowly proliferating cells. NSC 72151 and 268965 were equitoxic for both populations. NSC 94889, 638850, and 630938 were more cytotoxic in rapidly growing cells. In irt vitro time exposure studies, four compounds, NSC 268965, 280074, 281613, and 281817, were maximally cytotoxic with as little as 3 h exposure time. From an analysis comparing the p53 genotype of the 60 cell lines of the National Cancer Institute (NCI) Drug Screen with the cytotoxicity profiles for the 16 putative renal compounds, 13 compounds were classified as likely to be indifferent to p53 status. We also developed a panel specificity detection method for the NCI Drug Screen database to evaluate the. prevalence of renal sensitive compounds. Of the 16 studied compounds, 14 were among those identified as renal sensitive by the statistical analysis, Lastly, we found reduced tumor growth in mice with established renal human tumor xenografts after treatment with two of the renal active compounds, These studies describe compounds with potential renal activity that are candidates for preclinical development for renal cell carcinoma.
C1 NCI, Mol Therapeut Sect, Med Branch, NIH, Bethesda, MD 20892 USA.
   NCI, Dev Therapeut Program, NIH, Bethesda, MD 20892 USA.
   NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA.
   So Res Inst, Birmingham, AL 35255 USA.
RP Mertins, SD (reprint author), NCI, Mol Therapeut Sect, Med Branch, NIH, Bldg 10,Room 12N226, Bethesda, MD 20892 USA.
FU NCI NIH HHS [N01-CM-47000]
NR 43
TC 10
Z9 10
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI BIRMINGHAM
PA PO BOX 11806, BIRMINGHAM, AL 35202 USA
SN 1078-0432
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD MAR
PY 2001
VL 7
IS 3
BP 620
EP 633
PG 14
WC Oncology
SC Oncology
GA 418GT
UT WOS:000167883100027
PM 11297258
ER

PT J
AU Sampson, ML
   Aubry, A
   Csako, G
   Remaley, AT
AF Sampson, ML
   Aubry, A
   Csako, G
   Remaley, AT
TI Triple lipid screening test: A homogeneous sequential assay for
   HDL-cholesterol, total cholesterol, and triglycerides
SO CLINICAL CHEMISTRY
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY HEART-DISEASE
AB Background: The analysis of lipids in serum lipoprotein fractions is useful in assessing the risk for coronary artery disease, but it typically involves performing multiple tests. An automated single-tube assay, referred to as the triple lipid screening (TLS) test, can be used for measuring HDL-cholesterol (HDL-C), total cholesterol, and triglycerides (TGs) with no specimen pretreatment.
   Methods: The first part of the assay is based on a homogeneous assay for HDL-C that uses either an anti-apolipoprotein B antibody (TLS-A test) or a polyanion (TLS-B test) that blocks the enzymatic measurement of cholesterol on the non-HDL fraction. After the addition of deoxycholate, which solubilizes the unreacted cholesterol from the non-HDL fraction, the remaining cholesterol in the sample is subsequently measured enzymatically. Using the same enzyme defection system as the cholesterol assay, TGs are measured in the last step, after the addition of the enzymes for the TG assay.
   Results: The TLS assay (y) had acceptable analytic performance and compared favorably with standard tests (x) for each analyte: for HDL-C, TLS-A = 0.99x + 0.19 (R = 0.980); TLS-B = 1.00x - 0.15 (R = 0.974); for total cholesterol, TLS-A = 1.03x + 0.12 (R = 0.997); TLS-B = 1.07x - 0.30 (R = 0.965); and for TGs, TLS-A = 1.02x + 0.02 (R = 0.988); TLS-B = 1.04x - 0.28 (R = 0.980).
   Conclusions: The TLS test is a single-tube homogeneous assay for the analysis of ail of the major serum lipoprotein fractions and can be used as a simple screening test for the detection of hyperlipidemia. (C) 2001 American Association for Clinical Chemistry.
C1 NIH, Dept Lab Med, Clin Chem Serv, Ctr Clin, Bethesda, MD 20892 USA.
RP Remaley, AT (reprint author), NIH, Dept Lab Med, Clin Chem Serv, Ctr Clin, Bldg 10,Rm 2C-407, Bethesda, MD 20892 USA.
NR 20
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD MAR
PY 2001
VL 47
IS 3
BP 532
EP 539
PG 8
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 408VG
UT WOS:000167347700024
PM 11238308
ER

PT J
AU Hong, Y
   Rautaharju, PM
   Hopkins, PN
   Arnett, DK
   Djousse, L
   Pankow, JS
   Sholinsky, P
   Rao, DC
   Province, MA
AF Hong, Y
   Rautaharju, PM
   Hopkins, PN
   Arnett, DK
   Djousse, L
   Pankow, JS
   Sholinsky, P
   Rao, DC
   Province, MA
TI Familial aggregation of QT-interval variability in a general population:
   results from the NHLBI Family Heart Study
SO CLINICAL GENETICS
LA English
DT Article
DE familial aggregation; genetic epidemilogy; heritability; QT interval;
   segregation analysis
ID COMPLEX SEGREGATION ANALYSIS; POTASSIUM CHANNEL GENE; MOLECULAR-BASIS;
   CARDIOVASCULAR MORTALITY; VENTRICULAR ARRHYTHMIAS; CARDIAC-ARRHYTHMIA;
   SUDDEN-DEATH; RISK FACTOR; TWINS; PROLONGATION
AB QT-interval prolongation is associated with increased risk of cardiac death, Although information on genetics and molecular mechanisms of the congenital long QT syndrome is mounting, limited data are available on the genetics of QT interval in the general population. Heart rate adjusted QT intervals (Bazett's QTc, and QT index (QTI)) were assessed by electrocardiography in 2399 members aged 25-91 years of 468 randomly selected families participating in the NHLBI Family Heart Study, Familial correlation and segregation analyses were performed to evaluate the genetics of the variability of QT interval in this population. The parent-offspring (0.14 +/- 0.03) and sibling (0.18 +/- 0.03) correlations for age and sex-adjusted QTc were moderate, while the spouse correlation was close to zero (0.09 +/- 0.06). This suggests that there are familial/genetic influences on QT-interval variability. Segregation analysis results suggest that there is a major effect in addition to heritable multifactorial effects (h(2) = 0.34), but the major effect did not follow Mendelian inheritance. Further adjustments of QTc for other major cardiovascular risk factors did not significantly change the results, Similar results were found for QTI.
   The QT-interval variation in the general population is influenced by moderate heritable multifactorial effects in addition to a major effect. A major gene effect is not directly supported.
C1 Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.
   Wake Forest Univ, Dept Publ Hlth, Winston Salem, NC 27109 USA.
   Univ Utah, Salt Lake City, UT USA.
   Univ Minnesota, Dept Epidemiol, Minneapolis, MN USA.
   Boston Univ, Prevent Med & Epidemiol Sect, Boston, MA 02215 USA.
   Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
   NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA.
   Washington Univ, Dept Genet, St Louis, MO 63110 USA.
   Washington Univ, Dept Psychiat, St Louis, MO 63110 USA.
RP Hong, Y (reprint author), Washington Univ, Sch Med, Div Biostat, Campus Box 8067,660 S Euclid Ave, St Louis, MO 63110 USA.
FU NHLBI NIH HHS [U01 HL56565, U01 HL56563, U01 HL056567, U01 HL56569, U01
   HL56566, U01 HL56568, U01 HL56564]
NR 45
TC 28
Z9 28
U1 0
U2 0
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD MAR
PY 2001
VL 59
IS 3
BP 171
EP 177
DI 10.1034/j.1399-0004.2001.590305.x
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 414AQ
UT WOS:000167644100007
PM 11260226
ER

PT J
AU Fauci, AS
AF Fauci, AS
TI Infectious diseases: Considerations for the 21st century
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 38th Annual Meeting of the Infectious-Diseases-Society-of-America
CY SEP 06-11, 2000
CL NEW ORLEANS, LA
SP Infect Dis Soc Amer
ID COMPARATIVE GENOMICS; UNITED-STATES; RESISTANCE; VACCINES; SCIENCE;
   CANCER
AB The discipline of infectious diseases will assume added prominence in the 21st century in both developed and developing nations. To an unprecedented extent, issues related to infectious diseases in the context of global health are on the agendas of world leaders, health policymakers, and philanthropies. This attention has focused both on scientific challenges such as vaccine development and on the deleterious effects of infectious diseases on economic development and political stability. Interest in global health has led to increasing levels of financial support, which, combined with recent technological advances, provide extraordinary opportunities for infectious disease research in the 21st century. The sequencing of human and microbial genomes and advances in functional genomics will underpin significant progress in many areas, including understanding human predisposition and susceptibility to disease, microbial pathogenesis, and the development new diagnostics, vaccines, and therapies. Increasingly, infectious disease research will be linked to the development of the medical infrastructure and training needed in developing countries to translate scientific advances into operational reality.
C1 NIAID, NIH, Bethesda, MD 20892 USA.
RP Fauci, AS (reprint author), NIAID, NIH, Bldg 31,Room 7A-03,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM af10r@nih.gov
NR 59
TC 149
Z9 165
U1 3
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD MAR 1
PY 2001
VL 32
IS 5
BP 675
EP 685
DI 10.1086/319235
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 406ED
UT WOS:000167201200001
PM 11229834
ER

PT J
AU Cunningham, CK
   Wara, DW
   Kang, MH
   Fenton, T
   Hawkins, E
   McNamara, J
   Mofenson, L
   Duliege, AM
   Francis, D
   McFarland, EJ
   Borkowsky, W
AF Cunningham, CK
   Wara, DW
   Kang, MH
   Fenton, T
   Hawkins, E
   McNamara, J
   Mofenson, L
   Duliege, AM
   Francis, D
   McFarland, EJ
   Borkowsky, W
CA Pediat AIDS Clin Trials Grp 230 Coll
TI Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1)
   envelope vaccines in neonates born to HIV-1-Infected women
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID PERINATAL TRANSMISSION; INFECTED WOMEN; PHASE-I; ZIDOVUDINE; INFANTS;
   IMMUNOGENICITY; REDUCTION; TRIAL
AB To determine the safety of 2 candidate vaccines against human immunodeficiency virus type 1 (HIV-1), a randomized, placebo-controlled, multicenter trial compared low, medium, and high doses of the vaccines or an adjuvant among infants born to HIV-infected women. No local or systemic reactions of grade 2 or greater were reported 48 h after the subjects underwent immunization. Grade 3 or 4 chemistry toxicities occurred in 5 (3%) and grade 3 or 4 hematologic toxicities in 17 (11%) of 154 vaccinated subjects (not significantly different from 29 adjuvant recipients). CD4(+) cell percentages of less than or equal to 20% occurred at least once in 9 vaccinated subjects and 1 control subject. Sustained CD4(+) cell percentages of less than or equal to 20% occurred in 4 HIV-infected children. Fourteen infants (8%) were confirmed to be HIV-infected; median CD4(+) cell counts among these children were 2074, 1674, 1584, and 821 cells/mm(3) at birth and weeks 24, 52, and 104, respectively. Thus, both vaccines were safe and well tolerated in neonates, and there was no evidence of accelerated immunologic decline in HIV-infected infants.
C1 SUNY Hlth Sci Ctr, Dept Pediat, Syracuse, NY 13210 USA.
   NYU, Med Ctr, Dept Pediat, New York, NY 10016 USA.
   Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   Chiron Vaccines, Emeryville, CA USA.
   VaxGen, Brisbane, CA USA.
   Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
   NIAID, Rockville, MD USA.
   AIDS Clin Trials Grp Operat, Rockville, MD USA.
   NICHHD, Bethesda, MD 20892 USA.
   Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA.
RP Cunningham, CK (reprint author), SUNY Hlth Sci Ctr, Dept Pediat, 750 E Adams St, Syracuse, NY 13210 USA.
OI Mofenson, Lynne/0000-0002-2818-9808
NR 16
TC 48
Z9 51
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD MAR 1
PY 2001
VL 32
IS 5
BP 801
EP 807
DI 10.1086/319215
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 406ED
UT WOS:000167201200017
PM 11229849
ER

PT J
AU Gilron, I
   Booher, SL
   Rowan, JS
   Max, MB
AF Gilron, I
   Booher, SL
   Rowan, JS
   Max, MB
TI Topiramate in trigeminal neuralgia: A randomized, placebo-controlled
   multiple crossover pilot study
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE topiramate; trigeminal neuralgia; facial neuralgia; pain; placebo;
   crossover studies
ID PAIN; CURRENTS
AB We conducted a pilot study to evaluate the efficacy of topiramate in trigeminal neuralgia using a randomized, double-blind, placebo-controlled, two-period crossover design. Three patients were enrolled in and completed the study. All three patients responded to topiramate in this main study and entered a subsequent confirmatory study consisting of three topiramate-placebo crossovers. In the main study, topiramate reduced pain by 31%, 42%, and 64% in the three patients (p = 0.04). However, topiramate showed no effect in the confirmatory study. Given that trials of less common pain conditions are fraught with low patient recruitment rates, a multiple crossover design provides more information, which is important in conditions associated with considerable pain fluctuation. Larger trials are needed to more precisely estimate the effect of topiramate in trigeminal neuralgia.
C1 Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mechanisms Branch, NIH, Bethesda, MD 20892 USA.
   NIH, Dept Nursing, Ctr Clin, Bethesda, MD 20892 USA.
RP Max, MB (reprint author), Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mechanisms Branch, NIH, Room 3C-405, Bethesda, MD 20892 USA.
FU NIDCR NIH HHS [1Z01DE00366]
NR 11
TC 49
Z9 52
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-5664
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD MAR-APR
PY 2001
VL 24
IS 2
BP 109
EP 112
DI 10.1097/00002826-200103000-00009
PG 4
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 419RZ
UT WOS:000167963600009
PM 11307048
ER

PT J
AU Atkinson, AJ
   Colburn, WA
   DeGruttola, VG
   DeMets, DL
   Downing, GJ
   Hoth, DF
   Oates, JA
   Peck, CC
   Schooley, RT
   Spilker, BA
   Woodcock, J
   Zeger, SL
AF Atkinson, AJ
   Colburn, WA
   DeGruttola, VG
   DeMets, DL
   Downing, GJ
   Hoth, DF
   Oates, JA
   Peck, CC
   Schooley, RT
   Spilker, BA
   Woodcock, J
   Zeger, SL
CA Biomarkers Definitions Working Grp
TI Biomarkers and surrogate endpoints: Preferred definitions and conceptual
   framework
SO CLINICAL PHARMACOLOGY & THERAPEUTICS
LA English
DT Editorial Material
ID END-POINTS; CARDIOVASCULAR-DISEASE; CLINICAL-TRIALS; RISK-FACTORS;
   MARKERS; OUTCOMES
C1 NIH, Off Sci Policy, Bethesda, MD 20892 USA.
   NIH, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA.
   MDS Harris Inc, Phoenix, AZ USA.
   Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
   Univ Wisconsin, Dept Biostat, Madison, WI USA.
   Axys Pharmaceut, S San Francisco, CA USA.
   Vanderbilt Univ, Dept Med, Nashville, TN USA.
   Georgetown Univ, Ctr Drug Dev Sci, Washington, DC USA.
   Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA.
   Pharmaceut Res & Manufacturers Amer, Washington, DC USA.
   US FDA, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA.
   Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA.
RP Downing, GJ (reprint author), NIH, Off Sci Policy, Bldg 1,Rm 218,1 Ctr Dr, Bethesda, MD 20892 USA.
NR 28
TC 1606
Z9 1657
U1 17
U2 173
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0009-9236
J9 CLIN PHARMACOL THER
JI Clin. Pharmacol. Ther.
PD MAR
PY 2001
VL 69
IS 3
BP 89
EP 95
DI 10.1067/mcp.2000.113989
PG 7
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 413ZQ
UT WOS:000167641800001
ER

PT J
AU Abernethy, DR
   Barbey, JT
   Franc, J
   Brown, KS
   Feirrera, I
   Ford, N
   Salazar, DE
AF Abernethy, DR
   Barbey, JT
   Franc, J
   Brown, KS
   Feirrera, I
   Ford, N
   Salazar, DE
TI Loratadine and terfenadine interaction with nefazodone: Both
   antihistamines are associated with QTc prolongation
SO CLINICAL PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID ELECTROCARDIOGRAPHIC PHARMACODYNAMICS; DOSE PHARMACOKINETICS; K+
   CHANNELS; HUMAN HEART; ANTIDEPRESSANT; ERYTHROMYCIN; METABOLITES; SINGLE
AB Background and Objective: Nefazodone inhibits CYP3A; therefore coadministration with CYP3A substrates such as terfenadine or loratadine may result in increased exposure to these drugs. A potential pharmacodynamic consequence is electrocardiographic QTc prolongation, which has been associated with torsade de pointes cardiac arrhythmia. Therefore a clinical pharmacokinetic-pharmacodynamic evaluation of this potential interaction was conducted.
   Methods: A randomized, double-blind, double-dummy, parallel group, multiple-dose design was used. Healthy men and women who were given doses of 60 mg of terfenadine every 12 hours, 20 mg of loratadine once daily, and 300 mg of nefazodone every 12 hours were studied. Descriptive pharmacokinetics (time to maximum concentration, maximum concentration, and area under the plasma concentration-time curve) were used for the examination of interactions among the respective parent drugs and metabolites. QTc prolongation (mean value over the dosing interval) was the pharmacodynamic parameter measured. Kinetic and dynamic analysis was used for the examination of pooled concentration and QTc data with the use of a linear model.
   Results: Concomitant nefazodone treatment markedly increased the dose interval area under the plasma concentration-time curve of both terfenadine (mean value, 17.3 +/- 8.5 ng (.) mL/h versus 97.4 + 48.9 ng (.) mL/h; P < .001) and carboxyterfenadine (mean value, 1.69 <plus/minus> 0.48 mug (.) h/mL versus 2.88 +/- 0.53 mug h/mL; P < .001) and moderately increased the dose interval area under the plasma concentration-time curve of both loratadine (mean value, 31.5 <plus/minus> 27.9 ng (.) h/mL versus 43.7 +/- 25.9 ng (.) h/mL; P < .014) and descarboethoxyloratadine (mean value, 73.4 <plus/minus> 54.9 ng (.) h/mL versus 81.9 +/- 26.2 ng (.) h/mL; P < .002). The mean QTc was unchanged with terfenadine alone; however, it was markedly prolonged with concomitant nefazodone and terfenadine (mean [90% confidence interval] prolongation 42.4 ms [34.2, 50.6 ms]; P < .05). Similarly, the mean QTc was unchanged with loratadine alone; however, it was prolonged with concomitant nefazodone and loratadine (21.6 ms [13.7, 29.4 ms]; P < .05). Nefazodone alone did not change mean QTc. QTc was positively correlated with terfenadine plasma concentration (r(2) = 0.21; P = .0001). Similarly, QTc was positively correlated with loratadine plasma concentration (r(2) = 0.056; P = .0008) but with a flatter slope. There was no relationship between QTc and nefazodone plasma concentration during treatment with nefazodone alone(r(2) = 0.002, not significant).
   Conclusions: In healthy men and women, concomitant nefazodone treatment at a therapeutic dose increases exposure to both terfenadine and carboxyterfenadine. This increased exposure is associated with marked QTc prolongation, which is correlated with terfenadine plasma concentration. A similar interaction occurs with loratadine, although it is of lesser magnitude. Concomitant administration of nefazodone with terfenadine may have predisposed individuals to the arrhythmia associated with QTc prolongation, torsade de pointes, when terfenadine was available for clinical use. However, a new finding is that in the context of higher than clinically recommended daily doses (20 mg) of loratadine concomitant administration with a metabolic inhibitor such as nefazodone can also result in QTc prolongation.
C1 NIA, Gerontol Res Ctr, Baltimore, MD 21224 USA.
   Georgetown Univ, Sch Med, Div Clin Pharmacol, Washington, DC 20057 USA.
   Bristol Myers Squibb Co, Pharmaceut Res Inst, New York, NY 10154 USA.
RP Abernethy, DR (reprint author), NIA, Gerontol Res Ctr, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
NR 32
TC 33
Z9 37
U1 0
U2 0
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0009-9236
J9 CLIN PHARMACOL THER
JI Clin. Pharmacol. Ther.
PD MAR
PY 2001
VL 69
IS 3
BP 96
EP 103
DI 10.1067/mcp.2001.114230
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 413ZQ
UT WOS:000167641800002
PM 11240972
ER

PT J
AU Goel, V
   Pullara, SD
   Grafman, J
AF Goel, V
   Pullara, SD
   Grafman, J
TI A computational model of frontal lobe dysfunction, working memory and
   the Tower of Hanoi task
SO COGNITIVE SCIENCE
LA English
DT Article
DE frontal lobes; computational model; working memory; problem solving;
   tower of Hanoi; short-term memory; 3CAPS; production systems; planning;
   executive functions
ID PREFRONTAL CORTEX; SCHIZOPHRENIA; PERFORMANCE; IMPAIRMENTS; BEHAVIOR;
   PET
AB A symbolic computer model, employing the perceptual strategy, is presented for solving Tower of Hanoi problems. The model is calibrated-in terms of the number of problems solved, time taken, and number of moves made-to the performance of 20 normal subjects. It is then "lesioned" by increasing the decay rate of elements in working memory to model the performance of 20 patients with lesions to the prefrontal cortex. The model captures both the main effects of subject groups (patients and normal controls) performance, and the subject groups (patients and normal controls) by problem difficulty interactions. This leads us to support the working memory hypothesis of frontal lobe functions, but for a narrow range of problems, (C) 2001 Cognitive Science Society, Inc. All rights reserved.
C1 York Univ, Dept Psychol, Toronto, ON, Canada.
   Univ Aberdeen, Aberdeen, Scotland.
   Simon Fraser Univ, Sch Comp Sci, Vancouver, BC, Canada.
   NINDS, Cognit Neurosci Sect, NIH, Bethesda, MD 20892 USA.
RP Goel, V (reprint author), York Univ, Dept Psychol, Toronto, ON, Canada.
EM vgoel@yorku.ca
OI Grafman, Jordan H./0000-0001-8645-4457
NR 38
TC 35
Z9 38
U1 2
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0364-0213
J9 COGNITIVE SCI
JI Cogn. Sci.
PD MAR-APR
PY 2001
VL 25
IS 2
BP 287
EP 313
PG 27
WC Psychology, Experimental
SC Psychology
GA 419UK
UT WOS:000167966900004
ER

PT J
AU Sher, L
AF Sher, L
TI Genetic studies of seasonal affective disorder and seasonality
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID REPEAT LENGTH POLYMORPHISM; META-CHLOROPHENYLPIPERAZINE;
   BEHAVIORAL-RESPONSES; WINTER DEPRESSION; MOOD; PREVALENCE; ASSOCIATION;
   FLUOXETINE; HYPOTHESIS; LIGHT
AB Genetic studies of seasonal affective disorder (SAD) and seasonality have received considerable attention over the past several years. Studies of the prevalence of SAD and nonseasonal mood disorders among relatives of patients with SAD suggested a familial contribution to the development of SAD. Two twin studies demonstrated a substantial role of genetic variation in seasonality. Two genetic variants related to serotonergic transmission, the 8-HTTLPR and the 5-HT2A-1438G/A gene promoter polymorphisms, have been found to be associated with SAD. 5-HTTLPR is also associated with seasonality in SAD patients and in the general population. It is not clear whether SAD is inherited as a distinct entity or whether seasonality and depression are separate heritable traits that happen to coincide in certain individuals. Vulnerability to SAD and disease pathology may be influenced by many genes, perhaps on several chromosomes. Copyright (C) 2001 by W.B. Saunders Company.
C1 NIMH, Sect Biol Rhythms, Bethesda, MD 20892 USA.
RP Sher, L (reprint author), Columbia Univ, Dept Psychiat, New York State Psychiat Inst, Dept Neurosci, 1051 Riverside Dr,Suite 2917,Box 42, New York, NY 10032 USA.
NR 54
TC 26
Z9 28
U1 1
U2 5
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0010-440X
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD MAR-APR
PY 2001
VL 42
IS 2
BP 105
EP 110
DI 10.1053/comp.2001.21217
PG 6
WC Psychiatry
SC Psychiatry
GA 410AR
UT WOS:000167418300003
PM 11244145
ER

PT J
AU Green, MV
   Seidel, J
   Vaquero, JJ
   Lagoda, E
   Lee, I
   Eckelman, WC
AF Green, MV
   Seidel, J
   Vaquero, JJ
   Lagoda, E
   Lee, I
   Eckelman, WC
TI High resolution PET, SPECT and projection imaging in small animals
SO COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
LA English
DT Article; Proceedings Paper
CT Symposium on Frontiers in Nuclear Medicine Technology
CY MAY 06-07, 1999
CL MOL, BELGIUM
SP Ctr Etude Energie Nucl, Studie Centrum Kernenergie
DE small animal imagine; positron emission tomography; single photon
   emission computed tomography planar; mouse and rat models
ID DETECTOR MODULE; LSO CRYSTALS; PERFORMANCE; PHOTODIODE; SCANNER;
   TOMOGRAPH; MICROPET; DEPTH
AB Positron emission tomography. single photon emission computed tomography and planar projection imaging of radioactive tracers have long been in use for detecting and diagnosing disease in human subjects. More recently, advanced versions of these same technologies have begun to be used across the breadth of modern biomedical research to study non-invasively small laboratory animals in a myriad of experimental settings. In this report, we describe some of the new instruments and techniques that make these measurements possible and illustrate, with a few examples. the potential power of these methods in modern biomedical research. Published by Elsevier Science Ltd.
C1 NIH, Bethesda, MD 20892 USA.
RP Green, MV (reprint author), NIH, Room 1C401,Bldg 10, Bethesda, MD 20892 USA.
RI Vaquero, Juan Jose/D-3033-2009
OI Vaquero, Juan Jose/0000-0001-9200-361X
NR 24
TC 56
Z9 59
U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0895-6111
J9 COMPUT MED IMAG GRAP
JI Comput. Med. Imaging Graph.
PD MAR-APR
PY 2001
VL 25
IS 2
BP 79
EP 86
DI 10.1016/S0895-6111(00)00057-4
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 400TZ
UT WOS:000166888900003
PM 11137783
ER

PT J
AU Marcin, JP
   Slonim, AD
   Pollack, MM
   Ruttimann, UE
AF Marcin, JP
   Slonim, AD
   Pollack, MM
   Ruttimann, UE
TI Long-stay patients in the pediatric intensive care unit
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE length of stay; Pediatric Risk of Mortality Score; severity of illness;
   long-stay patients; scoring systems; prediction rules; critical care;
   intensive care; pediatrics; decision support; outliers
ID LENGTH; MORTALITY; RISK; MULTICENTER; SCORE; EFFICIENCY; SURGERY; COST;
   ICU
AB Objective: Length of stay in the pediatric intensive care unit (PICU) is a reflection of patient severity of illness and health status, as well as PICU quality and performance. We determined the clinical profiles and relative resource use of long-stay patients (LSPs) and developed a prediction model to identify LSPs for early quality and cost saving interventions.
   Design: Nonconcurrent cohort study.
   Setting: A total of 16 randomly selected PICUs and 16 volunteer PICUs.
   Patients: A total of 11,165 consecutive admissions to the 32 PICUs.
   Interventions: None.
   Measurements and Main Results: LSPs were defined as patients having a length of stay greater than the 95(th) percentile (> 12 days). Logistic regression analysis was used to determine which clinical characteristics, available within the first 24 hrs after admission, were associated with LSPs and to create a predictive algorithm. Overall, LSPs were 4.7% of the population but represented 36.1% of the days of care. Multivariate analysis indicated that the following factors are predictive of long stays: age < 12 months, previous ICU admission, emergency admission, no CPR before admission, admission from another ICU or intermediate care unit, chronic care requirements (total parenteral nutrition and tracheostomy), specific diagnoses including acquired cardiac disease, pneumonia, and other respiratory disorders, having never been discharged from the hospital, need for ventilatory support or an intracranial catheter, and a Pediatric Risk of Mortality III score between 10 and 33. The performance of the prediction algorithm in both the training and validation samples for identifying LSPs was good for both discrimination (area under the receiver operating characteristics curve of 0.83 and 0.85, respectively), and calibration (goodness of fit, p = .33 and p = .16, respectively). LSPs comprised from 2.1% to 8.1% of individual ICU patients and occupied from 15.2% to 57.8% of individual ICU bed days.
   Conclusions: LSPs have less favorable outcomes and use more resources than non-LSPs. The clinical profile of LSPs includes those who are younger and those that require chronic care devices. A predictive algorithm could help identify patients at high risk of prolonged stays appropriate for specific interventions.
C1 George Washington Univ, Sch Med, Childrens Res Inst,Dept Crit Care Med, Ctr Hlth Serv & Clin Res,Childrens Natl Med Ctr, Washington, DC 20052 USA.
   Univ Calif Davis, Dept Med, Sect Crit Care Med, Sacramento, CA 95817 USA.
   Natl Inst Alcohol Abuse, NIH, Bethesda, MD USA.
RP Marcin, JP (reprint author), George Washington Univ, Sch Med, Childrens Res Inst,Dept Crit Care Med, Ctr Hlth Serv & Clin Res,Childrens Natl Med Ctr, Washington, DC 20052 USA.
FU PHS HHS [MCH-110584]
NR 28
TC 52
Z9 57
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
J9 CRIT CARE MED
JI Crit. Care Med.
PD MAR
PY 2001
VL 29
IS 3
BP 652
EP 657
DI 10.1097/00003246-200103000-00035
PG 6
WC Critical Care Medicine
SC General & Internal Medicine
GA 411WM
UT WOS:000167522400027
PM 11373438
ER

PT J
AU Atweh, GF
   Schechter, AN
AF Atweh, GF
   Schechter, AN
TI Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar
   in sickle cell disease
SO CURRENT OPINION IN HEMATOLOGY
LA English
DT Article
ID ORAL SODIUM PHENYLBUTYRATE; GLOBIN GENE; TRANSCRIPTIONAL REPRESSION;
   ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; DIABETIC MOTHERS;
   RISK-FACTORS; HYDROXYUREA; ANEMIA; BUTYRATE
AB The favorable effects of high levels of fetal hemoglobin (Hb F) in sickle cell disease have been recognized for several decades. This has been an important incentive for the development of therapeutic agents that increase Hb F production. 5-Azacytidine, the first such agent in clinical use, was proposed based on a molecular understanding of the role of DNA methylation in globin gene regulation. Controversy over the mechanism of Hb F induction by 5-azacytidine led to the identification of hydroxyurea as another agent that can increase Hb F production. Although the clinical benefit of hydroxyurea has been demonstrated in a randomized clinical trial, greater increases in Hb F are clearly needed for optimal therapeutic effect. Butyrates also increase Hb F levels, and their use in combination with hydroxyurea appears to be synergistic. Now that multiple therapeutic agents are available for Hb F induction, the use of combination therapy to increase Hb F levels sufficiently to prevent all the complications of sickle cell disease has become a realistic goal. (C) 2001 Lippincott Williams & Wilkins, Inc.
C1 CUNY Mt Sinai Sch Med, Div Hematol, Dept Med, New York, NY 10029 USA.
   NIDDKD, Biol Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Atweh, GF (reprint author), CUNY Mt Sinai Sch Med, Div Hematol, Dept Med, 1 Gustave L Levy Pl, New York, NY 10029 USA.
OI Schechter, Alan N/0000-0002-5235-9408
NR 47
TC 44
Z9 45
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1065-6251
J9 CURR OPIN HEMATOL
JI Curr. Opin. Hematol.
PD MAR
PY 2001
VL 8
IS 2
BP 123
EP 130
DI 10.1097/00062752-200103000-00010
PG 8
WC Hematology
SC Hematology
GA 446RZ
UT WOS:000169527400010
PM 11224687
ER

PT J
AU Le, YY
   Oppenheim, JJ
   Wang, JM
AF Le, YY
   Oppenheim, JJ
   Wang, JM
TI Pleiotropic roles of formyl peptide receptors
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE formyl peptide receptors; signal transduction; HIV-1; Alzheimer's
   disease
ID N-FORMYLPEPTIDE RECEPTOR; PROTEIN-COUPLED RECEPTORS;
   METHIONYL-LEUCYL-PHENYLALANINE; C5A CHEMOATTRACTANT RECEPTORS;
   SIGNAL-TRANSDUCTION PATHWAYS; LIPOXIN A(4) RECEPTOR; HIV-1 ENVELOPE
   GP41; ALZHEIMERS-DISEASE; HUMAN NEUTROPHILS; HUMAN PHAGOCYTES
AB FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides. these receptors are thought to play a role in host defense against microbial infection. Recently, a variety of novel agonists have been identified for these receptors, including several host-derived endogenous molecules that are involved in proinflammatory responses. Most notably is the use of FPRL1 by at least three amyloidogenic protein and peptide ligands, the serum amyloid A (SAA), the 42 amino acid form of beta amyloid (A beta (42)), and the prion peptide PrP106-126, to chemoattract and activate human phagocytic leukocytes. These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions. (C) 2001 Published by Elsevier Science Ltd.
C1 Natl Canc Inst, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
RP Le, YY (reprint author), Natl Canc Inst, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
NR 145
TC 139
Z9 141
U1 1
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD MAR
PY 2001
VL 12
IS 1
BP 91
EP 105
DI 10.1016/S1359-6101(01)00003-X
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 421LW
UT WOS:000168066700009
PM 11312121
ER

PT J
AU Shakhov, AN
   Nedospasov, SA
AF Shakhov, AN
   Nedospasov, SA
TI Expression profiling in knockout mice: lymphotoxin versus tumor necrosis
   factor in the maintenance of splenic microarchitecture
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE subtractive cloning; gene arrays; spleen; cytokines
ID ALTERNATIVE COMPLEMENT PATHWAY; SECONDARY LYMPHOID-TISSUES; POLYMERASE
   CHAIN-REACTION; SCAVENGER RECEPTOR MARCO; CELL-ADHESION MOLECULE;
   BETA-DEFICIENT MICE; LUNG-CANCER RISK; GENE-EXPRESSION; B-CELL;
   PHOSPHOLIPASE A(2)
AB Expression profiling provides a powerful approach to define the underlying molecular mechanisms in disease. Several techniques referred collectively to as gene profiling may be also helpful in the analysis of the phenotype of mice with targeted mutations, especially if applied to distinct histological compartments, to specific cell types or to evaluate the effect of specific challenges, such as infection. Here we review several of the existing techniques applicable to genetic knockout studies, and share our experience from the study of mice with tumor necrosis factor (TNF) and lymphotoxin (LT) deficiencies, with specific emphasis on the distinction between TNF- and LT-mediated signalling pathways in vivo. Gene expression profiling analysis of TNF/LT-deficient mice supports the notion that TNF and LT, originally discovered as distinct biological activities, manifest both distinct and redundant functions in vivo. Published by Elsevier Science Ltd.
C1 NCI, Intramural Res Support Program, SAIC Frederick, FCRDC, Frederick, MD 21702 USA.
   NCI, Div Basic Sci, Mol Immunoregulat Lab, FCRDC, Frederick, MD 21702 USA.
   Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119899, Russia.
   Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 117984, Russia.
RP Shakhov, AN (reprint author), NCI, Intramural Res Support Program, SAIC Frederick, FCRDC, Bldg 560,Room 31-33,POB B, Frederick, MD 21702 USA.
RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015;
   Nedospasov, Sergei/Q-7319-2016
FU NCI NIH HHS [N01-CO-56000]
NR 106
TC 10
Z9 11
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD MAR
PY 2001
VL 12
IS 1
BP 107
EP 119
DI 10.1016/S1359-6101(01)00004-1
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 421LW
UT WOS:000168066700010
PM 11312122
ER

PT J
AU Maskos, U
   Brustle, O
   McKay, RDG
AF Maskos, U
   Brustle, O
   McKay, RDG
TI Long-term survival, migration, and differentiation of neural cells
   without functional NMDA receptors in vivo
SO DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE neural precursors; transplantation; in utero; NMDA receptor; knock-out
   mouse; survival; migration; differentiation; neurons; glia
ID METHYL-D-ASPARTATE; HIPPOCAMPAL-NEURONS; DEVELOPING BRAIN;
   PURKINJE-CELLS; EXPRESSION; BLOCKADE; DEATH; MICE; NEURODEGENERATION;
   POTENTIATION
AB The NMDA receptor, one of the two major ionotropic glutamate receptors, has been proposed to play fundamental roles in the survival, migration, differentiation, and activity-dependent maturation of neural cells. The NR1 gene encodes the major subunit that is responsible for channel function, and NR1 -/- mice die at birth, inhibiting the study of glutamate signaling in postnatal neurons. The properties of cells lacking the NR1 subunit of NMDA receptors were studied by transplanting dissociated telencephalic, diencephalic, and mesencephalic cells of E14 mouse embryos with a targeted deletion of the NR1 gene into the ventricles of embryonic rats using intrauterine transplantation (Brustle et at, 1995, Neuron 15, 1275-1285). The transplanted cells took part in the normal development of the host brain where they survived after migration into a large number of brain structures. Morphological and immunohistochemical analysis suggests that NR1 -/- cells can differentiate normally in these sites. The results provide evidence that NMDA-receptor-initiated signals are not required for the postnatal differentiation and survival of many types of neurons in the central nervous system, in a noncell autonomous fashion after transplantation into a wild-type environment. (C) 2001 Academic Press.
C1 NINDS, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Maskos, U (reprint author), Inst Pasteur, CNRS URA 2182, F-75724 Paris 15, France.
NR 38
TC 8
Z9 8
U1 1
U2 2
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0012-1606
J9 DEV BIOL
JI Dev. Biol.
PD MAR 1
PY 2001
VL 231
IS 1
BP 103
EP 112
DI 10.1006/dbio.2000.0141
PG 10
WC Developmental Biology
SC Developmental Biology
GA 407KP
UT WOS:000167271000008
PM 11180955
ER

PT J
AU Nomura, T
   Yabe, T
   Mochizuki, H
   Reiser, J
   Becerra, SP
   Schwartz, JP
AF Nomura, T
   Yabe, T
   Mochizuki, H
   Reiser, J
   Becerra, SP
   Schwartz, JP
TI Survival effects of pigment epithelium-derived factor expressed by a
   lentiviral vector in rat cerebellar granule cells
SO DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE neurotrophic factor; pigment epithelium-derived factor; cerebellar
   granule cells; lentiviral vector; bicistronic vector; tat
ID GENE-TRANSFER; NONDIVIDING CELLS; FACTOR PEDF; MOTOR-NEURONS; DEATH;
   EFFICIENT; SYSTEM; TAT; IDENTIFICATION; NEUROTOXICITY
AB We have previously shown that pigment epithelium-derived factor (PEDF) acts as a survival factor for cerebellar granule cells (CGCs), by blocking apoptotic death, and can also protect these cells against glutamate-induced neurotoxicity. In preparation for gene therapy studies, pseudotyped HIV-1-based lentiviral vectors containing the PEN gene, as well as either green fluorescent protein or beta -galactosidase, were prepared. These bicistronic vectors are unique in that they express two genes efficiently under one promoter. Primary cell cultures of CGCs from postnatal day 8 rats were infected with the vectors encoding PEDF. RT-PCR demonstrated expression of mRNA and Western blot analysis confirmed that infected CGCs secrete PEN protein to the medium. Assays for cell survival demonstrated that PEDF-infected cells were significantly more protected compared with mock-infected controls for 6-8 days in culture, as well as against induced apoptosis. The PEN vectors expressing tat (trans-acting transcription factor) provided more protection than the tat(-) vectors. These results demonstrate that while the lentiviral vectors expressing PEN are as neuroprotective as the protein itself for CGCs, the vectors have the advantage of providing long-lasting expression of PEDF protein, which will be more effective in in vivo studies. The present results suggest that this system may be useful for gene therapy for neurodegenerative disorders. Copyright (C) 2001 S. Karger AG, Basel.
C1 NINDS, NTFS, Neurotroph Factors Sect, NIH, Bethesda, MD 20892 USA.
   NINDS, Dev & Metab Neurol Branch, NIH, Bethesda, MD 20892 USA.
   NEI, Retinal Cell & Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Schwartz, JP (reprint author), NINDS, NTFS, Neurotroph Factors Sect, NIH, Bldg 36,Room 4A31, Bethesda, MD 20892 USA.
NR 29
TC 14
Z9 15
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-5866
J9 DEV NEUROSCI-BASEL
JI Dev. Neurosci.
PD MAR-APR
PY 2001
VL 23
IS 2
BP 145
EP 152
DI 10.1159/000048706
PG 8
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 467DV
UT WOS:000170686600007
PM 11509837
ER

PT J
AU Westergaard, GC
   Lussier, ID
   Suomi, SJ
   Higley, JD
AF Westergaard, GC
   Lussier, ID
   Suomi, SJ
   Higley, JD
TI Stress correlates of hand preference in rhesus macaques
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Article
DE cortisol; handedness; laterality; primates, stress
ID EARLY EXPERIENCE; CHIMPANZEES PAN; BRAIN ASYMMETRY; MACACA-MULATTA;
   HANDEDNESS; BEHAVIOR; MONKEYS; EMOTION; LATERALITY; HEMISPHERE
AB In this research we examined stress-related correlates of hand preference in monkeys. Specifically we tested the hypothesis that stress reactivity and plasma levels of the stress hormone cortisol are developmentally related to handedness in rhesus macaques (Macaca mulatta). We found a significant positive correlation between cortisol levels sampled in juveniles and the frequency of right- versus left-hand use sampled in these same animals during adulthood. Right-hand preference tvas negatively correlated with stress reactivity. These data are consistent with the vier-v that stress functioning and reactivity are associated with the development of hemispheric specialization in primates (C) 2001 John Wiley & Sons, Inc.
C1 LABS Virginia Inc, Div Res & Dev, Yemassee, SC USA.
   NICHHD, Comparat Ethol Lab, Bethesda, MD 20892 USA.
   NIAAA, Clin Studies Lab, Bethesda, MD 20892 USA.
RP Westergaard, GC (reprint author), LABS Virginia Inc, Div Res & Dev, Yemassee, SC USA.
FU NCRR NIH HHS [R24 RR09983, 5U42RR05083]
NR 32
TC 19
Z9 20
U1 5
U2 11
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0012-1630
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD MAR
PY 2001
VL 38
IS 2
BP 110
EP 115
DI 10.1002/1098-2302(200103)38:2<110::AID-DEV1003>3.0.CO;2-#
PG 6
WC Developmental Biology; Psychology
SC Developmental Biology; Psychology
GA 401KN
UT WOS:000166926900004
PM 11223803
ER

PT J
AU Westergaard, GC
   Champoux, M
   Suomi, SJ
AF Westergaard, GC
   Champoux, M
   Suomi, SJ
TI Plasma cortisol is associated with handedness in infant rhesus monkeys
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Article
DE handedness; cortisol; stress; rhesus macaque; laterality
ID CHIMPANZEES PAN-TROGLODYTES; MACAQUES MACACA-MULATTA; HAND PREFERENCE;
   CEREBRAL LATERALIZATION; BIOLOGICAL MECHANISMS; PREGNANT ADOLESCENTS;
   EARLY EXPERIENCE; PRENATAL STRESS; BIMANUAL TASK; ASYMMETRIES
AB In this research we examined the relationship between plasma cortisol and handedness in infant rhesus macaques (Macaca mulatta). Specifically, we tested the hypothesis that stress functioning is related to hemispheric specialization and manifested in a positive correlation between cortisol levels and the frequency of right- versus left- hand use. we found a significant positive relationship between cortisol levels sampled at ages 1 and 3 months and lateral bias toward greater use of the right hand versus left hand sampled between ages 4 and 11 months. Further; we found a significant negative relationship between cortisol sampled at age 5 months and strength of lateral bias (independent of direction). These data suggest an early developmental ii influence of stress functioning on hemispheric specialization for manual control in infant monkey's. (C) 2001 John Wiley & Sons, Inc.
C1 LABS Virginia Inc, Div Res, Yemassee, SC 29902 USA.
   NICHHD, Comparat Ethol Lab, Poolesville, MD 20837 USA.
RP Westergaard, GC (reprint author), LABS Virginia Inc, Div Res, Yemassee, SC 29902 USA.
FU NCRR NIH HHS [R24 RR09983]
NR 30
TC 10
Z9 10
U1 1
U2 5
PU JOHN WILEY & SONS INC
PI NEW YORK
PA 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0012-1630
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD MAR
PY 2001
VL 38
IS 2
BP 116
EP 122
DI 10.1002/1098-2302(200103)38:2<116::AID-DEV1004>3.0.CO;2-R
PG 7
WC Developmental Biology; Psychology
SC Developmental Biology; Psychology
GA 401KN
UT WOS:000166926900005
PM 11223804
ER

PT J
AU Flotte, T
   Agarwal, A
   Wang, JM
   Song, SH
   Fenjves, ES
   Inverardi, L
   Chesnut, K
   Afione, S
   Loiler, S
   Wasserfall, C
   Kapturczak, M
   Ellis, T
   Nick, H
   Atkinson, M
AF Flotte, T
   Agarwal, A
   Wang, JM
   Song, SH
   Fenjves, ES
   Inverardi, L
   Chesnut, K
   Afione, S
   Loiler, S
   Wasserfall, C
   Kapturczak, M
   Ellis, T
   Nick, H
   Atkinson, M
TI Efficient ex vivo transduction of pancreatic islet cells with
   recombinant adeno-associated virus vectors
SO DIABETES
LA English
DT Article
ID ADENOASSOCIATED VIRUS; GENE-THERAPY; CYSTIC-FIBROSIS; EXPRESSION;
   AUTOIMMUNE; TYPE-2; INTERLEUKIN-10; INFECTION; GRAFT
AB The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency to induce host inflammatory responses have limited previous gene delivery studies using viral transfer vectors. We demonstrate here that recombinant adeno-associated virus (rAAV) serotype 2, a vector that can overcome these limitations, effectively transduces both human and murine pancreatic islet cells with reporter genes as well as potentially important immunoregulatory cytokine genes (interleukin-4, interleukin-10), although a very high multiplicity of infection (10,000 infectious units/islet equivalent) was required. This requirement was alleviated by switching to rAAV serotype 5, which efficiently transduced islets at a multiplicity of infection of 100. Although adenovirus (Ad) coinfection was required for efficient ex vivo expression at early time points, islets transduced without Ad expressed efficiently when they were transplanted under the renal capsule and allowed to survive in vivo, The rAAV-delivered transgenes did not interfere with islet cell insulin production and were expressed in both beta- and non-beta -cells. We believe rAAV will provide a useful tool to deliver therapeutic genes for modulating immune responses against islet cells and markedly enhance longterm graft survival.
C1 Univ Florida, Dept Pathol, Gainesville, FL 32610 USA.
   Univ Florida, Inst Genet, Gainesville, FL 32610 USA.
   Univ Florida, Powell Gene Therapy Ctr, Gainesville, FL 32610 USA.
   Univ Florida, Dept Med, Gainesville, FL 32610 USA.
   Univ Florida, Dept Pediat, Gainesville, FL 32610 USA.
   Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA.
   Univ Miami, Diabet Res Inst, Miami, FL 33152 USA.
   NHLBI, Mol Hematol Branch, Bethesda, MD 20892 USA.
RP Atkinson, M (reprint author), Univ Florida, Dept Pathol, Box 100275 JHMHC,1600 SW Archer Rd, Gainesville, FL 32610 USA.
RI e-, a/F-9947-2012; wasserfall, clive/J-9078-2012
OI wasserfall, clive/0000-0002-3522-8932
FU NHLBI NIH HHS [HL-59412]; NIDDK NIH HHS [DK-51809]
NR 27
TC 63
Z9 65
U1 0
U2 3
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1660 DUKE ST, ALEXANDRIA, VA 22314 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD MAR
PY 2001
VL 50
IS 3
BP 515
EP 520
DI 10.2337/diabetes.50.3.515
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 407JX
UT WOS:000167269400005
PM 11246870
ER

PT J
AU Brozinick, JT
   McCoid, SC
   Reynolds, TH
   Nardone, NA
   Hargrove, DM
   Stevenson, RW
   Cushman, SW
   Gibbs, EM
AF Brozinick, JT
   McCoid, SC
   Reynolds, TH
   Nardone, NA
   Hargrove, DM
   Stevenson, RW
   Cushman, SW
   Gibbs, EM
TI GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes
   but is not a lifelong cure
SO DIABETES
LA English
DT Article
ID GLUCOSE-TRANSPORTER GLUT4; SKELETAL-MUSCLE; TRANSGENIC MICE; PERFUSED
   HINDQUARTERS; INSULIN; PROTEIN; RAT; TRANSLOCATION; METABOLISM; BASAL
AB We previously reported that overexpression of GLUT4 in lean, nondiabetic C57BL/KsJ-lepr(db/+) (db/+) mice resulted in improved glucose tolerance associated with increased basal and insulin-stimulated glucose transport in isolated skeletal muscle. We used the diabetic (db/db) litter mates of these mice to examine the effects of GLUT4 overexpression on in vivo glucose utilization and on in vitro glucose transport and GLUT4 translocation in diabetic mice. We examined in vivo glucose disposal by oral glucose challenge and hyperinsulinemic-hyperglycemic clamps. We also evaluated the in vitro relationship between glucose transport activity and cell surface GLUT4 levels as assessed by photolabeling with the membrane-impermeant reagent 2-N-(4-(1-azi-2,2,2-trifluoroethyl)benzoyl)-1,3-bis(D-mannose-4-yloxy)-2-propylamine in extensor digitorum longus (EDL) muscles. All parameters were examined as functions of animal age and the level of GLUT4 overexpression. In young mice (age 10-12 weeks), both lower (two- to threefold) and higher (four- to fivefold) levels of GLUT4 overexpression were associated with improved glucose tolerance compared to age-matched nontransgenic (NTG) mice. However, glucose tolerance deteriorated with age in db/db mice, although less rapidly in transgenic mice expressing the higher level of GLUT4. Glucose infusion rates during hyperinsulinemic-hyperglycemic clamps were increased with GLUT4 overexpression, compared with NTG mice in both lower and higher levels of GLUT4 overexpression, even in the older mice. Surprisingly, isolated EDL muscles from diabetic db/db mice did not exhibit alterations in either basal or insulin-stimulated glucose transport activity or cell surface GLUT4 compared to nondiabetic db/+ mice. Furthermore, both GLUT4 overexpression levels and animal age are associated with increased basal and insulin-stimulated glucose transport activities and cell surface GLUT4, However, the observed increased glucose transport activity in older db/db mice was not accompanied by an equivalent increase in cell surface GLUT4 compared to younger animals. Thus, although in vivo glucose tolerance is improved with GLUT4 overexpression in young animals, it deteriorates with age; in contrast, insulin responsiveness as assessed by the clamp technique remains improved with GLUT4 overexpression, as does in vitro insulin action. In summary, despite an impairment in whole-body glucose tolerance, skeletal muscle of the old transgenic GLUT4 db/db mice is still insulin responsive in vitro and in vivo.
C1 Pfizer Inc, Cent Res & Dev, Dept Cardiovasc & Metab Dis, Groton Labs, Groton, CT 06340 USA.
   NIDDK, Expt Diabet Metab & Nutr Sect, DB, NIH, Bethesda, MD USA.
RP Gibbs, EM (reprint author), Pfizer Inc, Cent Res & Dev, Dept Cardiovasc & Metab Dis, Groton Labs, Groton, CT 06340 USA.
NR 31
TC 43
Z9 48
U1 0
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1660 DUKE ST, ALEXANDRIA, VA 22314 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD MAR
PY 2001
VL 50
IS 3
BP 593
EP 600
DI 10.2337/diabetes.50.3.593
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 407JX
UT WOS:000167269400014
PM 11246879
ER

PT J
AU Saydah, SH
   Eberhardt, MS
   Loria, CM
   Brancati, FL
AF Saydah, SH
   Eberhardt, MS
   Loria, CM
   Brancati, FL
TI Subclinical stales of glucose intolerance and risk of death in the US
SO DIABETES CARE
LA English
DT Article
ID CORONARY HEART-DISEASE; CARDIOVASCULAR-DISEASE; FOLLOW-UP; ALL-CAUSE;
   MORTALITY; TOLERANCE; HYPERGLYCEMIA; MEN; TOLBUTAMIDE; POPULATION
AB OBJECTIVE - Although clinically evident type 2 diabetes is a it ell-established cause of mortality, less is known about subclinical states of glucose intolerance. RESEARCH
   DESIGN AND METHODS - Data from the Second National Health and Nutrition Examination Survey Mortality Study, a prospective study of adults, were analyzed. This analysis focused on a nationally representative sample of 3,174 adults aged 30-75 years who underwent an oral glucose tolerance rest at baseline (1976-1980) and who were followed up for death through 1992.
   RESULTS - Using 1985 World Health Organization criteria, adults were classified as having previously diagnosed diabetes (n = 248), undiagnosed diabetes (n = 183), impaired glucose tolerance (IGT) (n = 480), or normal glucose tolerance (n = 2,263). For these groups, cumulative all-cause mortality through age 70 was 41, 34, 27, and 20%, respectively (P < 0.001). Compared with those with normal glucose tolerance, the multivariate adjusted RR of all-cause mortality was greatest for adults with diagnosed diabetes (RR2.11, 95% CI 1.56-2.84), followed by those with undiagnosed diabetes (1.77, 1.13-2.75) and those with IGT(1.42, 1.08-1.87; P < 0.001). A similar pattern of risk was observed For cardiovascular disease mortality.
   CONCLUSIONS - In the U.S., there was a gradient of mortality associated with abnormal glucose tolerance ranging from a 40% greater risk in adults with IGT to a 110% greater risk in adults with clinically evident diabetes. These associations were independent of established cardiovascular disease risk factors.
C1 Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA.
   NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA.
   Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Off Anal Epidemiol & Hlth Promot, Atlanta, GA USA.
   Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
RP Brancati, FL (reprint author), Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, 2024 E Monument St,Suite 2-600, Baltimore, MD 21205 USA.
FU NHLBI NIH HHS [T32 HL07024-26]
NR 31
TC 145
Z9 149
U1 0
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1660 DUKE ST, ALEXANDRIA, VA 22314 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2001
VL 24
IS 3
BP 447
EP 453
DI 10.2337/diacare.24.3.447
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 407KR
UT WOS:000167271200007
PM 11289466
ER

PT J
AU Harris, MI
AF Harris, MI
TI Racial and ethnic differences in health care access and health outcomes
   for adults with type 1 diabetes
SO DIABETES CARE
LA English
DT Article
ID NON-HISPANIC WHITES; MEXICAN-AMERICANS; MANAGED-CARE; GLYCEMIC CONTROL;
   MELLITUS; RACE; ORGANIZATION; RETINOPATHY; POPULATION; CANCER
AB OBJECTIVE - To evaluate health care access and utilization and health status and outcomes for type 2 diabetic patients according to race and ethnicity and to determine whether health status is influenced by health care access and utilization.
   RESEARCH DESIGN AND METHODS - National samples of Caucasians, African-Americans, and Mexican-Americans were studied in the third National Health and Nutrition Examination Survey. Information on medical history and treatment of diabetes, health care access and utilization, and health status and outcomes was obtained by structured questionnaires and by clinical and laboratory assessments.
   RESULTS - Almost all patients in each race and ethnic group had one primary source of ambulator), medical care (92-97%), saw one physician at this source (83-92%), and had at least semiannual physician visits (83-90%). Almost all patients greater than or equal to 65 years of age had health insurance (99-100%), and for those patients <65 years of age, Caucasians (91%) and African-Americans (89%) had higher rates of coverage than Mexican-Americans (66%). Rates of treatment with insulin or oral agents (71-78%), eye examination in the precious year (61-70%), blood pressure check in the previous 6 months (83-89%), and the proportion of hypertension that was diagnosed (84-91%) were similar for each race and ethnic group. Lower proportions of African-Americans and Mexican-Americans self-monitored their blood glucose (insulin-treated, 27 vs. 44% of Caucasians), had their cholesterol checked (62-68 vs. 81%), and had their dyslipidemia diagnosed (45 vs. 58%). African-American and Mexican-American patients had a somewhat higher proportion than Caucasian patients, with HbA(1c)<greater than or equal to>7% (58-66 vs. 55%), blood pressure greater than or equal to 140/90 mmHg among those with diagnosed hypertension (60-65 vs. 55%), and clinical proteinuria (11-14 vs. 5%). In contrast, they had better levels of total cholesterol (greater than or equal to 24 mg/dl) (28-30 vs. 34%) and HDL cholesterol (greater than or equal to 45 mg/dl) (46-59 vs. 38%), and African-American and Mexican-American men were less overweight than Caucasian men (BMI greater than or equal to 30) (34-37 vs. 44%), although the opposite was true for women. LDL cholesterol levels and the proportion of patients who smoked cigarettes or were hospitalized in the past year were similar among all three groups. In logistic regression analysis, there was little evidence that levels of blood glucose, blood pressure, lipids, or albuminuria were associated with access to or utilization of health care or with socioeconomic status.
   CONCLUSIONS - There are some differences by race and ethnicity in health care access and utilization and in health status and outcomes for adults with type 2 diabetes. However, the magnitude of these differences pale in comparison with the suboptimal health status of all three race and ethnic groups relative to established treatment goals. Health status does not appear to be influenced by access to health cart.
C1 NIDDKD, Bethesda, MD 20892 USA.
RP Harris, MI (reprint author), NIDDK, NIH, 6707 Democracy Blvd,Room 695,MSC5460, Bethesda, MD 20892 USA.
NR 33
TC 225
Z9 227
U1 2
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1660 DUKE ST, ALEXANDRIA, VA 22314 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2001
VL 24
IS 3
BP 454
EP 459
DI 10.2337/diacare.24.3.454
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 407KR
UT WOS:000167271200008
PM 11289467
ER

PT J
AU Le Roith, D
   Zick, Y
AF Le Roith, D
   Zick, Y
TI Recent advances in our understanding of insulin action and insulin
   resistance
SO DIABETES CARE
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-B; INDUCED TYROSINE
   PHOSPHORYLATION; GLYCOGEN-SYNTHASE KINASE-3; RECEPTOR SUBSTRATE-1 IRS-1;
   GLUCOSE-TRANSPORT; FACTOR-ALPHA; PHOSPHATIDYLINOSITOL 3-KINASE;
   SKELETAL-MUSCLE; PPAR-GAMMA
C1 NIH, Clin Endocrinol Branch, Bethesda, MD 20892 USA.
   Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel.
RP Le Roith, D (reprint author), NIH, Moll Cell Endocrine Branch, Rm 8D12,Bldg 10,MSC 1758, Bethesda, MD 20892 USA.
NR 110
TC 170
Z9 181
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1660 DUKE ST, ALEXANDRIA, VA 22314 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2001
VL 24
IS 3
BP 588
EP 597
DI 10.2337/diacare.24.3.588
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 407KR
UT WOS:000167271200027
PM 11289486
ER

PT J
AU Vezza, PR
   Wilder, AM
   Holland, SM
   Abati, AD
AF Vezza, PR
   Wilder, AM
   Holland, SM
   Abati, AD
TI Detection of fungal organisms in pulmonary cytology samples of chronic
   granulomatous disease: A comparison of alternate techniques
SO DIAGNOSTIC CYTOPATHOLOGY
LA English
DT Letter
C1 NIH, Cytopathol Sect, Bethesda, MD 20892 USA.
RP Vezza, PR (reprint author), NIH, Cytopathol Sect, Bldg 10, Bethesda, MD 20892 USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 8755-1039
J9 DIAGN CYTOPATHOL
JI Diagn. Cytopathol.
PD MAR
PY 2001
VL 24
IS 3
BP 226
EP 227
DI 10.1002/1097-0339(200103)24:3<226::AID-DC1048>3.0.CO;2-Y
PG 2
WC Medical Laboratory Technology; Pathology
SC Medical Laboratory Technology; Pathology
GA 407JZ
UT WOS:000167269600017
PM 11241912
ER

PT J
AU Schluter, V
   Rabe, C
   Meyer, M
   Koshy, R
   Caselmann, WH
AF Schluter, V
   Rabe, C
   Meyer, M
   Koshy, R
   Caselmann, WH
TI Intracellular accumulation of middle hepatitis B surface protein
   activates gene transcription
SO DIGESTIVE DISEASES
LA English
DT Article
DE MESH; hepatocellular carcinoma, virology; hepatitis B virology;
   hepatitis B surface antigens, metabolism; hepatitis B virus, genetics,
   metabolism and; ultrastructure; transactivation genetics;
   transactivators, metabolism
ID NF-KAPPA-B; TRANSGENIC MOUSE MODEL; HEPATOCELLULAR-CARCINOMA; VACCINIA
   VIRUS; ENDOPLASMIC-RETICULUM; NUCLEOTIDE-SEQUENCE; EXPRESSION SYSTEM;
   PRES/S-SEQUENCES; RNA-POLYMERASE; MICE
AB While the natural intact protein does not possess any transactivator function, C-terminal truncation of the middle hepatitis B surface (MHBs) protein yields a novel transactivator function, We have previously found that the truncated transactivator protein, MHBs(t167), is not secreted but retained within the secretory pathway. Here, we provide evidence that when full-length MHBs is coexpressed with the truncated MHBs(t167) protein, the secretion of the full-length protein is inhibited and both proteins accumulate within the cell. We further show that MHBs, forcibly retained in the cell by C-terminal fusion to the endoplasmic reticulum retention signal KDEL (MHBsKDEL), mimics the effects of MHBs(t167) in enhancing the nuclear-binding activity of transcription factors NFkappaB and AP-1, and activation of NFkappaB- and AP-1-dependent transcription of reporter genes. As is the case for MHBs(t167), MHBsKDEL-dependent activation of NFkappaB is inhibited by the antioxidant N-acetyl-L-cysteine indicating the involvement of reactive oxygen intermediates and suggesting a similar mechanism of activation. This study suggests that the intracellular retention and accumulation of the normally secreted MHBs leads to oxidative stress and activation of transcription. This may be an important but not exclusive mechanism in hepatocarcinogenesis. Copyright (C) 2002 S. Karger AG, Basel.
C1 Univ Bonn, Dept Med 1, D-53105 Bonn, Germany.
   Max Planck Inst Biochem, Dept Virus Res, D-82152 Martinsried, Germany.
   Hoffmann La Roche Ag, CH-4002 Basel, Switzerland.
   NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD USA.
RP Caselmann, WH (reprint author), Univ Bonn, Dept Med 1, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM Caselmann@uni-bonn.de
NR 38
TC 7
Z9 9
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
J9 DIGEST DIS
JI Dig. Dis.
PD MAR
PY 2001
VL 19
IS 4
BP 352
EP 363
DI 10.1159/000050703
PG 12
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 541AB
UT WOS:000174962100013
PM 11935096
ER

PT J
AU Gibril, F
   Lindeman, RJ
   Abou-Saif, A
   Sojamanesh, H
   Roy, PK
   Peghini, PL
   Reynolds, JC
   Lubensky, IA
   Jensen, RT
AF Gibril, F
   Lindeman, RJ
   Abou-Saif, A
   Sojamanesh, H
   Roy, PK
   Peghini, PL
   Reynolds, JC
   Lubensky, IA
   Jensen, RT
TI Retained gastric antrum syndrome - A forgotten, treatable cause of
   refractory peptic ulcer disease
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE gastrinoma; gastric surgery; hypergastrinemia; gastric hypersecretion;
   Zollinger-Ellison syndrome
ID BARRETTS ESOPHAGUS; DIAGNOSIS; SCINTIGRAPHY; SCAN
C1 NIDDK, DDB, NIH, Bethesda, MD 20892 USA.
   Potomac Physician Associates, Bethesda, MD 20817 USA.
   NIH, Dept Nucl Med, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA.
   NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
RP Jensen, RT (reprint author), NIDDK, DDB, NIH, Bldg 10,Room 9C-103,10 Ctr Dr,MSC 1804, Bethesda, MD 20892 USA.
NR 43
TC 8
Z9 8
U1 0
U2 0
PU KLUWER ACADEMIC/PLENUM PUBL
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0163-2116
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAR
PY 2001
VL 46
IS 3
BP 610
EP 617
DI 10.1023/A:1005667719847
PG 8
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 421ZB
UT WOS:000168092500028
PM 11318541
ER

PT J
AU Mandal, AK
   Zhang, ZJ
   Chou, JY
   Zimonjic, D
   Keck, CL
   Popescu, N
   Mukherjee, AB
AF Mandal, AK
   Zhang, ZJ
   Chou, JY
   Zimonjic, D
   Keck, CL
   Popescu, N
   Mukherjee, AB
TI Molecular characterization of murine pancreatic phospholipase A(2)
SO DNA AND CELL BIOLOGY
LA English
DT Article
ID CANCER CELL-LINE; BINDING-SITE; DARIERS-DISEASE; MESANGIAL CELLS;
   GROUP-I; RECEPTOR; GENE; EXPRESSION; CLONING; RAT
AB The pancreatic secretory phospholipase A(2) (sPLA(2)IB) is considered to be a digestive enzyme, although it has several important receptor-mediated functions. In this study, using the newly isolated murine sPLA(2)IB cDNA clone as a probe, we demonstrate that in addition to the pancreas, the sPLA(2)IB mRNA was expressed in extrapancreatic organs such as the liver, spleen, duodenum, colon, and lungs. We also demonstrate that sPLA(2)IB mRNA expression was detectable from the 17(th) day of gestation in the developing mouse fetus, coinciding with the time of completion of differentiation of the pancreas. Furthermore, the mRNA expression pattern of sPLA(2)IB was distinct from those of sPLA(2)IIA and cPLA(2) in various tissues examined. The murine sPLA(2)IB gene structure is well conserved, consistent with findings in other mammalian species, and this gene mapped to the region of mouse chromosome 5P1-G1.1. Taken together, our results suggest that sPLA(2)IB plays important roles both in the pancreas and in extrapancreatic tissues and that in the mouse, its expression is developmentally regulated.
C1 NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH, Bethesda, MD 20892 USA.
   NICHHD, Sect Cellular Differentiat, Heritable Disorders Branch, NIH, Bethesda, MD 20892 USA.
   NCI, NIH, Bethesda, MD 20892 USA.
RP Mukherjee, AB (reprint author), NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH, Bldg 10,Room 9S241, Bethesda, MD 20892 USA.
NR 53
TC 5
Z9 5
U1 0
U2 0
PU MARY ANN LIEBERT INC PUBL
PI LARCHMONT
PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA
SN 1044-5498
J9 DNA CELL BIOL
JI DNA Cell Biol.
PD MAR
PY 2001
VL 20
IS 3
BP 149
EP 157
DI 10.1089/104454901300068988
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
GA 418KG
UT WOS:000167889400004
PM 11313018
ER

PT J
AU Stafford, D
   LeSage, MG
   Rice, KC
   Glowa, JR
AF Stafford, D
   LeSage, MG
   Rice, KC
   Glowa, JR
TI A comparison of cocaine, GBR 12909, and phentermine self-administration
   by rhesus monkeys on a progressive-ratio schedule
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE cocaine; GBR 12909; phentermine; progressive ratio; self-administration;
   pharmacotherapy; abuse potential
ID FIXED-RATIO; FOOD; GBR-12909; BEHAVIOR; METHYLPHENIDATE; DELIVERY
AB The dopamine reuptake inhibitor GBR 12909 and the dopamine releaser phentermine may have potential for the treatment of cocaine abuse in humans. Pre-session treatment with either drug can decrease cocaine-maintained responding in rhesus monkeys while not affecting food-maintained responding. Both drugs are self-administered, but in some reports the patterns of responding they maintain differ from typical cocaine-reinforced responding. This study compared self-administration of cocaine (1-100 mug/kg/inj), GBR 12909 (3-100 mug/kg/inj), and phentermine (10-170 mug/kg/inj) in rhesus monkeys on a progressive-ratio schedule. Individual unit doses of each drug were available across several consecutive sessions. Cocaine self-administration was typical: the average number of ratios completed per session was a bitonic (increasing/decreasing) function of unit dose. Phentermine self-administration was variable across subjects (two of four monkeys self-administered reliably); one subject exhibited clear signs of behavioral toxicity. Self-administration of GBR 12909 was similarly variable across subjects. In the two subjects that self-administered GBR 12909 reliably, self-administration of small to mid-sized unit doses was enhanced following exposure to large unit doses. These data indicate that differences in self-administration of these drugs can be observed under progressive ratio procedures. Further, the data add to existing evidence suggesting that phentermine and GBR 12909 have at least moderate potential to be abused by humans. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
C1 Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA.
   NIDDK, Med Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Glowa, JR (reprint author), Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, 1501 Kings Highway, Shreveport, LA 71130 USA.
FU NIDA NIH HHS [DA 09820]
NR 28
TC 28
Z9 28
U1 0
U2 0
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0376-8716
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD MAR 1
PY 2001
VL 62
IS 1
BP 41
EP 47
DI 10.1016/S0376-8716(00)00158-7
PG 7
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 406CB
UT WOS:000167196400005
PM 11173166
ER

PT J
AU Jacobsen, LK
   Giedd, JN
   Kreek, MJ
   Gottschalk, C
   Kosten, TR
AF Jacobsen, LK
   Giedd, JN
   Kreek, MJ
   Gottschalk, C
   Kosten, TR
TI Quantitative medial temporal lobe brain morphology and
   hypothalamic-pituitary-adrenal axis function in cocaine dependence: a
   preliminary report
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE brain imaging; hormonal effects; magnetic resonance imaging; cocaine
   dependence
ID POSITRON EMISSION TOMOGRAPHY; INTRAVENOUS COCAINE; ABUSERS;
   SCHIZOPHRENIA; VULNERABILITY; HIPPOCAMPUS; CORTISOL; VOLUME; MRI; MEN
AB Preclinical and clinical studies have shown that cocaine increases plasma adrenocorticotropin hormone (ACTH) and cortisol. Chronic elevation of plasma cortisol exerts direct toxic effects upon hippocampal neurons and exacerbates hippocampal damage resulting from ischemia and seizures. The authors tested for evidence of hippocampal damage in patients with chronic cocaine dependence. Medial temporal lobe and total brain volumes were quantified using magnetic resonance imaging (MRI) in 27 patients with cocaine dependence and 16 healthy subjects. Basal and ovine corticotropin releasing hormone (oCRH) stimulated ACTH and cortisol levels were also examined in a subset of 8 healthy and 9 cocaine dependent subjects after 21 days of abstinence. No evidence for decreased hippocampal or total brain volume in cocaine dependence was observed. Similarly, basal and oCRH stimulated ACTH and cortisol levels in cocaine dependent patients did not differ from those in healthy subjects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
C1 Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia.
   Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA.
   VA Connecticut Healthcare Syst, W Haven, CT 06516 USA.
   NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
   Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10021 USA.
RP Jacobsen, LK (reprint author), Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia.
RI Giedd, Jay/A-3080-2008; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978
FU NCRR NIH HHS [RR00125]; NIDA NIH HHS [DA09250, DA04060, DA00167]
NR 47
TC 15
Z9 16
U1 1
U2 3
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0376-8716
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD MAR 1
PY 2001
VL 62
IS 1
BP 49
EP 56
DI 10.1016/S0376-8716(00)00159-9
PG 8
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 406CB
UT WOS:000167196400006
PM 11173167
ER

PT J
AU Miles, DR
   van den Bree, MBM
   Gupman, AE
   Newlin, DB
   Glantz, MD
   Pickens, RW
AF Miles, DR
   van den Bree, MBM
   Gupman, AE
   Newlin, DB
   Glantz, MD
   Pickens, RW
TI A twin study on sensation seeking, risk taking behavior and marijuana
   use
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE genetic and environmental influences; marijuana use; sensation seeking;
   risk taking; add health study
ID ADOLESCENT SEXUAL-BEHAVIOR; POPULATION-BASED SAMPLE;
   HIGH-SCHOOL-STUDENTS; SEAT-BELT USE; DRUG-USE; GENETIC INFLUENCES;
   SUBSTANCE USE; ENVIRONMENTAL-INFLUENCES; MOTORCYCLE DRIVERS; EARLY
   ADULTHOOD
AB The contribution of genetic and environmental factors to the covariation between risk-taking and marijuana use was assessed in adolescent twins. Genetic factors were found to significantly influence some traits (i.e. risk-taking attitude), while familial environmental factors were important for others (i.e. sexual promiscuity). For marijuana use, genetic and environmental factors were equally important; however, the association between risk taking and marijuana use may not be comparable for different behaviors. Results suggest that different etiological factors may underlie various risk taking traits which is relevant to both prevention efforts and attempts to identify genes involved in risk taking and shared genetic influences with substance use. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
C1 Virginia Commonwealth Univ, Richmond, VA 23298 USA.
   Natl Inst Drug Abuse, Baltimore, MD 21224 USA.
   NIDA, Bethesda, MD 20892 USA.
RP Miles, DR (reprint author), Virginia Commonwealth Univ, POB 98003, Richmond, VA 23298 USA.
RI turton, miranda/F-4682-2011
FU Medical Research Council [G9810900]; NICHD NIH HHS [P01-HD31921]
NR 68
TC 72
Z9 72
U1 1
U2 6
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0376-8716
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD MAR 1
PY 2001
VL 62
IS 1
BP 57
EP 68
DI 10.1016/S0376-8716(00)00165-4
PG 12
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 406CB
UT WOS:000167196400007
PM 11173168
ER

PT J
AU Yu, LJ
   Matias, J
   Scudiero, DA
   Hite, KM
   Monks, A
   Sausville, EA
   Waxman, DJ
AF Yu, LJ
   Matias, J
   Scudiero, DA
   Hite, KM
   Monks, A
   Sausville, EA
   Waxman, DJ
TI P450 enzyme expression patterns in the NCI human tumor cell line panel
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID NATIONAL-CANCER-INSTITUTE; ANTICANCER DRUG SCREEN; HUMAN CYTOCHROME-P450
   ENZYMES; GENE-THERAPY; CYCLOPHOSPHAMIDE; AGENTS; ACTIVATION;
   CHEMOTHERAPY; SENSITIVITY; RESISTANCE
AB Cytochrome P450 (P450) enzyme expression patterns were determined for a panel of 60 human tumor cell lines, representing nine tumor tissue types, used by the National Cancer Institute (NCI) Anticancer Drug Screening Program. All 60 tumor cell lines displayed significant P450 activity, as well as P450 reductase activity, as determined using the general P450 substrate 7-benzyloxyresorufin. Cell line-specific P450 enzyme patterns were observed using three other P450 substrates, 7-ethoxycoumarin, coumarin, and 7-ethoxyresorufin, each of which was metabolized at a low rate. Using a pattern-matching computer program, COMPARE, correlative relationships were investigated between the arrays of P450 activities and the patterns of cytotoxicity exhibited by a large group of anticancer agents of proven or potential clinical utility. Significant negative correlations between the patterns of P450-dependent 7-benzyloxyresorufin metabolism activity and cell line chemosensitivity were observed for 10 standard anticancer agents (including 6 alkylating agents) and 55 investigational compounds, suggesting a role for P450 metabolism in the inactivation of these agents. Negative correlations between 7-ethoxycoumarin O-deethylation and cell line chemosensitivity to a group of topoisomerase inhibitors were also seen, again suggesting P450-dependent drug inactivation. P450 enzyme profiling may thus aid in interpreting the patterns of drug sensitivity and resistance in the NCI tumor cell panel, and may facilitate the identification of anticancer agents whose activity can be altered via cytochrome P450 metabolism.
C1 Boston Univ, Dept Biol, Div Cell & Mol Biol, Boston, MA 02215 USA.
   NCI, SAIC Frederick, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA.
   NCI, Dev Therapeut Program, Bethesda, MD 20892 USA.
RP Waxman, DJ (reprint author), Boston Univ, Dept Biol, Div Cell & Mol Biol, 5 Cummington St, Boston, MA 02215 USA.
FU NCI NIH HHS [CA49248, N01-CO-56000]
NR 38
TC 71
Z9 77
U1 0
U2 2
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0090-9556
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD MAR
PY 2001
VL 29
IS 3
BP 304
EP 312
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 402KC
UT WOS:000166985300016
PM 11181500
ER

PT J
AU Krizek, DM
   Rick, ME
AF Krizek, DM
   Rick, ME
TI Clinical application of a rapid method using agarose gel electrophoresis
   and Western blotting to evaluate von Willebrand factor protease activity
SO ELECTROPHORESIS
LA English
DT Article
DE von Willebrand factor; multimers; von Willebrand factor protease
ID THROMBOTIC THROMBOCYTOPENIC PURPURA; HEMOLYTIC-UREMIC SYNDROME;
   FACTOR-CLEAVING PROTEASE; VONWILLEBRAND-FACTOR; HUMAN-PLASMA;
   PROTEOLYSIS; MULTIMERS; DISEASE
AB A method for evaluating the activity of the von Willebrand factor (vWF) protease is described, and a clinical application is illustrated. The procedure utilizes gel electrophoresis, Western blotting, and luminographic detection methods to evaluate the distribution of vWF multimers before and after incubation of clinical samples under conditions that favor proteolysis by this enzyme. Physiologically, the high-molecular-weight multimers of vWF are cleaved by the vWF protease under conditions of high shear stress in parts of the arterial circulation; cleavage of vWF multimers is also observed after exposure of vWF to denaturing agents in vitro and thus can serve as a laboratory test for the activity of the protease. vWF protease activity is decreased or absent in patients with thrombotic thrombocytopenic purpura due to an inhibiting autoantibody, and this leads to high levels of noncleaved vWF and to life-threatening thrombosis, thrombocytopenia and anemia. The assay evaluates the activity of the protease by assessing the cleavage of VWF multimers after patient plasmas are incubated in vitro under denaturing conditions. With the use of these electrophoresis and Western blotting techniques, patient plasmas can be rapidly assessed for the activity of the vWF protease which may aid in the treatment strategy for these patients.
C1 NIH, Warren Grant Magnuson Clin Ctr, Hematol Serv, Bethesda, MD 20892 USA.
RP Rick, ME (reprint author), NIH, Warren Grant Magnuson Clin Ctr, Hematol Serv, Bldg 10,Room 2C 390,10 Ctr Dr, Bethesda, MD 20892 USA.
EM mrick@cc.nih.gov
NR 17
TC 6
Z9 6
U1 1
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0173-0835
J9 ELECTROPHORESIS
JI Electrophoresis
PD MAR
PY 2001
VL 22
IS 5
BP 946
EP 949
DI 10.1002/1522-2683()22:5<946::AID-ELPS946>3.0.CO;2-U
PG 4
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 422BK
UT WOS:000168097900018
ER

PT J
AU Leitner, WW
AF Leitner, WW
TI Myth, menace or medical blessing? The clinical potential and the
   problems of genetic vaccines
SO EMBO REPORTS
LA English
DT Editorial Material
ID DNA
C1 NCI, NIH, Surg Branch, Bethesda, MD 20892 USA.
RP Leitner, WW (reprint author), NCI, NIH, Surg Branch, Bethesda, MD 20892 USA.
RI Leitner, Wolfgang/F-5741-2011
OI Leitner, Wolfgang/0000-0003-3125-5922
NR 7
TC 3
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1469-221X
J9 EMBO REP
JI EMBO Rep.
PD MAR
PY 2001
VL 2
IS 3
BP 168
EP 170
DI 10.1093/embo-reports/kve054
PG 3
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 412QU
UT WOS:000167566500004
PM 11266352
ER

PT J
AU Henderson, DK
AF Henderson, DK
TI HIV postexposure prophylaxis in the 21st century
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 4th Decennial International Conference on Nosocomial and
   Healthcare-Associated Infections in Conjunction with the 10th Annual
   Meeting of SHEA
CY MAR 05-09, 2000
CL ATLANTA, GEORGIA
SP SHEA
ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEALTH-CARE WORKERS; TO-CHILD
   TRANSMISSION; PERINATAL TRANSMISSION; OCCUPATIONAL EXPOSURE; ZIDOVUDINE
   PROPHYLAXIS; LYMPHOCYTE RESPONSES; INFANT TRANSMISSION; RANDOMIZED
   TRIAL; ORAL ZIDOVUDINE
AB The administration of postexposure prophylaxis has become the standard of care for occupational exposures to HIV. We have learned a great deal about the safety and potential efficacy of these agents, as well as the optimal management of health-care workers occupationally exposed to HIV. This article describes the current state of knowledge in this field, identifies substantive questions to be answered, and summarizes basic principles of postexposure management.
C1 NIH, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA.
RP Henderson, DK (reprint author), Bldg 10,Room 2C146,9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 44
TC 13
Z9 15
U1 0
U2 0
PU CENTER DISEASE CONTROL
PI ATLANTA
PA ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAR-APR
PY 2001
VL 7
IS 2
BP 254
EP 258
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 422HG
UT WOS:000168112000021
PM 11294718
ER

PT J
AU Merke, DP
   Cutler, GB
AF Merke, DP
   Cutler, GB
TI New ideas for medical treatment of congenital adrenal hyperplasia
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; CENTRAL PRECOCIOUS PUBERTY; CORTISOL
   PRODUCTION-RATE; 21-HYDROXYLASE DEFICIENCY; ADULT HEIGHT;
   GROWTH-HORMONE; FINAL HEIGHT; RECEPTOR ANTAGONIST; CUSHINGS-SYNDROME;
   CONTROLLED TRIAL
AB Since the introduction of glucocorticoid and mineralocorticoid replacement therapy approximately 50 years ago, the standard treatment principles of 21-hydroxylase deficiency have remained largely unchanged. Glucocorticoid is given in doses sufficient to suppress adrenal androgen secretion, and mineralocorticoid is given to normalize electrolytes and plasma renin activity. This treatment strategy often fails to normalize the growth and development of children with congenital adrenal hyperplasia (CAH), and management is often complicated by iatrogenic Cushing's syndrome, inadequately treated hyperandrogenism, and, later in life, infertility. This article addresses the clinical problems patients with CAH continue to have and outlines new ideas for the medical treatment of this condition.
C1 NICHHD, Warren Grant Magnuson Clin Ctr, NIH, Bethesda, MD 20892 USA.
   NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
   Eli Lilly & Co, Growth & Recovery Res Invest, Indianapolis, IN 46285 USA.
RP Merke, DP (reprint author), NICHHD, Warren Grant Magnuson Clin Ctr, NIH, Bldg 10,Room 13S260,10 Ctr Dr MSC 1932, Bethesda, MD 20892 USA.
NR 59
TC 21
Z9 27
U1 0
U2 1
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0889-8529
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD MAR
PY 2001
VL 30
IS 1
BP 121
EP +
DI 10.1016/S0889-8529(08)70022-7
PG 16
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 426AT
UT WOS:000168327500008
PM 11344931
ER

PT J
AU Goehl, TJ
AF Goehl, TJ
TI Introduction: Reviews of Environmental Health, 2001
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Editorial Material
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
RP Goehl, TJ (reprint author), NIEHS, POB 12233, Res Triangle Pk, NC 27709 USA.
NR 20
TC 0
Z9 0
U1 0
U2 0
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2001
VL 109
SU 1
BP 3
EP 4
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 412KQ
UT WOS:000167553900001
PM 11250800
ER

PT J
AU Dorman, DC
   Allen, SL
   Byczkowski, JZ
   Claudio, L
   Fisher, JE
   Fisher, JW
   Harry, GJ
   Li, AA
   Makris, SL
   Padilla, S
   Sultatos, LG
   Mileson, BE
AF Dorman, DC
   Allen, SL
   Byczkowski, JZ
   Claudio, L
   Fisher, JE
   Fisher, JW
   Harry, GJ
   Li, AA
   Makris, SL
   Padilla, S
   Sultatos, LG
   Mileson, BE
TI Methods to identify and characterize developmental neurotoxicity for
   human health risk assessment. III: Pharmacokinetic and pharmacodynamic
   considerations
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE developmental neurotoxicity; pharmacodynamics; pharmacokinetics;
   physiologically based pharmacokinetic modeling; rat
ID BLOOD-BRAIN-BARRIER; GENDER-RELATED DIFFERENCES; PLASMA-PROTEIN BINDING;
   DEVELOPING RAT-BRAIN; SPRAGUE-DAWLEY RATS; TRANS-RETINOIC ACID;
   HEAT-SHOCK-PROTEIN; HUMAN-BREAST MILK; LACTATIONAL TRANSFER;
   2-METHOXYACETIC ACID
AB We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occurred. Several pharmacokinetic processes (absorption, distribution, metabolism, and excretion) govern chemical disposition within the dam and the nervous system of the offspring. in addition, unique physical features such as the presence or absence of a placental barrier and the gradual development of the blood-brain barrier influence chemical disposition and thus modulate developmental neurotoxicity. Neonatal exposure may depend on maternal pharmacokinetic processes and transfer of the xenobiotic through the milk, although direct exposure may occur through other routes (e.g., inhalation). Measurement of the xenobiotic in milk and evaluation of biomarkers of exposure or effect following exposure can confirm or characterize neonatal exposure. Physiologically based pharmacokinetic and pharmacodynamic models that incorporate these and other determinants can estimate tissue dose and biologic response following in utero or neonatal exposure. These models can characterize dose-response relationships and improve extrapolation of results from animal studies to humans. In addition, pharmacologic data allow an experimenter to determine whether exposure to the lest chemical is adequate, whether exposure occurs during critical periods of nervous system development, whether route and duration of exposure are appropriate, and whether developmental neurotoxicity can be differentiated from direct actions of the xenobiotic.
C1 ARCADIS Geraghty & Miller, Millersville, MD 21108 USA.
   Chem Ind Inst Toxicol, Res Triangle Pk, NC 27709 USA.
   Zeneca Cent Toxicol Lab, Macclesfield, Cheshire, England.
   Mt Sinai Sch Med, Div Environm & Occupat Med, New York, NY USA.
   US FDA, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA.
   Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA.
   Natl Inst Environm Hlth Sci, Neurotoxicol Grp, Res Triangle Pk, NC USA.
   Monsanto Co, Metab & Safety Evaluat Newstead Lab, St Louis, MO USA.
   US EPA, Off Prevent Pesticides & Tox Subst, Washington, DC 20460 USA.
   US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA.
   Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pharmacol & Toxicol, Newark, NJ 07103 USA.
RP Dorman, DC (reprint author), ARCADIS Geraghty & Miller, 1131 Benfield Blvd,Suite A, Millersville, MD 21108 USA.
NR 181
TC 26
Z9 26
U1 3
U2 3
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2001
VL 109
SU 1
BP 101
EP 111
DI 10.2307/3434851
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 412KQ
UT WOS:000167553900011
PM 11250810
ER

PT J
AU Huff, J
AF Huff, J
TI Sawmill chemicals and carcinogenesis
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Editorial Material
DE arsenic; carcinogenesis bioassays; CCA; creosotes; dioxins;
   formaldehyde; pentachlorophenol; phenol; polychlorophenols; sawmill
   chemicals; TCDD; wood dust
ID DIMETHYLARSINIC ACID; WOOD DUST; EPIDEMIOLOGIC EVIDENCE; OCCUPATIONAL
   EXPOSURE; EXPERIMENTAL-ANIMALS; POOLED REANALYSIS; HEPATIC NEOPLASMS;
   SINONASAL CANCER; FORMALDEHYDE; WORKERS
AB Workers in wood industries are exposed to variable medleys of chemicals, both natural and synthetic. Additional exposures include Fungi, bacteria, bark and wood dusts, solvents, paints, and various other wood coatings. These individual and conglomerate exposures have been associated with diverse occupational illnesses and hazards, including cancers. In this commentary, I summarize both experimental and epidemiologic carcinogenesis results for several chemicals used in the wood industry, as well as for wood dust. Working in the wood industries entails excess risks of cancers, among other diseases and workplace injuries. A key to preventing occupationally and environmentally associated cancers, as in the wood industries, is avoiding exposures to chemicals and wood dusts and, in particular, chemicals known to cause cancer in animals or/and humans.
C1 NIEHS, Res Triangle Pk, NC 27709 USA.
RP Huff, J (reprint author), NIEHS, POB 12233, Res Triangle Pk, NC 27709 USA.
NR 76
TC 9
Z9 9
U1 1
U2 8
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2001
VL 109
IS 3
BP 209
EP 212
DI 10.2307/3434686
PG 4
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 416HQ
UT WOS:000167774600020
PM 11333179
ER

PT J
AU Keim, SA
   Alavanja, MCR
AF Keim, SA
   Alavanja, MCR
TI Pesticide use by persons who reported a high pesticide exposure event in
   the Agricultural Health Study
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE pesticides; pesticide poisoning; accidental exposures; farmers;
   noncancer toxicity
AB Almost 16% of the pesticide applicators in the Agricultural Health Study (AHS) cohort (a cohort that includes 52,629 private applicators) reported having a high pesticide exposure event (i.e., an incident or experience while using a pesticide that caused an unusually high personal exposure). Pesticides involved in these events were compared to the frequency with which specific pesticides were ever used by the AHS cohort. Generally, pesticides with greater acute toxicity were more frequently involved with the high pesticide exposure event than were other pesticides. Whereas it is clear that the use of acutely toxic pesticides may be related to more frequent visits to health care facilities, the reason that the spills and immersions of the high pesticide exposure events are associated with the acute toxicity of the pesticide is not intuitively clear. This analysis suggests that current practices directed at minimizing pesticide exposures may not be sufficient for acutely toxic or irritating chemicals.
C1 NCI, Occupat Epidemiol Branch, Bethesda, MD 20892 USA.
RP Keim, SA (reprint author), NCI, Occupat Epidemiol Branch, Bethesda, MD 20892 USA.
RI Keim, Sarah/F-8929-2013
OI Keim, Sarah/0000-0003-3490-3649
FU NCI NIH HHS [N01-CP-21095, N01-CP-33047]
NR 11
TC 4
Z9 4
U1 0
U2 1
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
J9 ENVIRON RES
JI Environ. Res.
PD MAR
PY 2001
VL 85
IS 3
BP 256
EP 259
DI 10.1006/enrs.2000.4224
PG 4
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 411YE
UT WOS:000167526600010
PM 11237514
ER

PT J
AU Bell, EM
   Hertz-Picciotto, I
   Beaumont, JJ
AF Bell, EM
   Hertz-Picciotto, I
   Beaumont, JJ
TI A case-control study of pesticides and fetal death due to congenital
   anomalies
SO EPIDEMIOLOGY
LA English
DT Article
DE fetal death; pesticides; congenital anomalies; phosphates; pyrethroids;
   halogenated hydrocarbons; carbamates; endocrine disrupters
ID AGRICULTURAL WORK; BIRTH-DEFECTS; PREGNANCY; EXPOSURE; MALFORMATIONS;
   CHEMICALS; MORTALITY; RISK
AB We examined the association between late fetal death due to congenital anomalies (73 cases, 611 controls) and maternal residential proximity to pesticide applications in ten California counties. A statewide database of all applications of restricted pesticides was linked to maternal address to determine daily exposure status. We examined five pesticide chemical classes. The odds ratios from logistic regression models, adjusted for maternal age and county, showed a consistent pattern with respect to timing of exposure; the largest risks for fetal death due to congenital anomalies were from pesticide exposure during the 3rd-8th weeks of pregnancy. For exposure either in the square mile of the maternal residence or in one of the adjacent 8 square miles, odds ratios ranged from 1,4 (95% confidence interval = 0.8-2.4) for phosphates, carbamates, and endocrine disrupters to 2.2 (95% confidence interval = 1.3-3.9) for halogenated hydrocarbons. Similar odds ratios were observed when a more restrictive definition of nonexposure (not exposed to any of the five pesticide classes during the 3rd-8th weeks of pregnancy) was used. The odds ratios for all pesticide classes increased when exposure occurred within the same square mile of maternal residence.
C1 Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   Beaumont Epidemiol, Davis, CA USA.
RP Bell, EM (reprint author), NCI, Occupat Epidemiol Branch, 6120 Executive Blvd,EPS 8111,MSC 7240, Bethesda, MD 20892 USA.
FU NIEHS NIH HHS [ES03767]
NR 29
TC 90
Z9 95
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD MAR
PY 2001
VL 12
IS 2
BP 148
EP 156
DI 10.1097/00001648-200103000-00005
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 405CJ
UT WOS:000167139400005
PM 11246574
ER

PT J
AU Reddy, DS
   Kim, HY
   Rogawski, MA
AF Reddy, DS
   Kim, HY
   Rogawski, MA
TI Neurosteroid withdrawal model of perimenstrual catamenial epilepsy
SO EPILEPSIA
LA English
DT Article
DE neurosteroid; allopregnanolone; progesterone; catamenial epilepsy;
   GABA(A) receptor
ID RECEPTOR ALPHA-4 SUBUNIT; GABA(A) RECEPTOR; ANTICONVULSANT TOLERANCE;
   PREMENSTRUAL-SYNDROME; LUTEINIZING-HORMONE; PSEUDOPREGNANT RAT;
   MENSTRUAL-CYCLE; A RECEPTOR; PROGESTERONE; BRAIN
AB Purpose: Perimenstrual catamenial epilepsy, the increase in seizure frequency that some women with epilepsy experience near the time of menstruation. may in part be related to withdrawal of the progesterone metabolite allopregnanolone, an endogenous anticonvulsant neurosteroid that is a potent positive allosteric gamma -aminobutyric acid, (GABA,) receptor modulator. The objective of this study was to develop an animal model of perimenstrual catamenial epilepsy for use in evaluating drug-treatment strategies.
   Methods: A state of prolonged high serum progesterone (pseudopregnancy) was induced in 26-day-old female rats by sequential injection of pregnant mares' serum gonadotropin and human chorionic gonadotropin. Neurosteroid withdrawal was induced by treatment with finasteride (100 mg/kg, i.p.), a 5 alpha -reductase inhibitor that blocks the conversion of progesterone to allopregnanolone. Plasma progesterone and allopregnanolone levels were measured by gas chromatography/electron capture negative chemical ionization mass spectrometry. Seizure susceptibility was evaluated with the convulsant pentylenetetrazol (PTZ).
   Results: Plasma allopregnanolene levels were markedly increased during pseudopregnancy (peak level, 55.1 vs, control diestrous level, 9.3 ng/mL) and were reduced by 86% 24 h after finasteride treatment (6.4 ng/mL). Progesterone levels were unaffected by finasteride. After finasteride-induced withdrawal, rats showed increased susceptibility to PTZ seizures. There was a significant increase in the number of animals exhibiting clonic seizures when challenged with subcutaneous PTZ (60 mg/kg) compared with control pseudopregnant animals not undergoing withdrawal and nonpseudopregnant diestrous females. The CD50 (50% convulsant dose) was 46 mg/kg, compared with 73 mg/kg in nonwithdrawn pseudopregnant animals and 60 mg/kg in diestrous controls. The threshold doses for induction of various seizure signs, measured by constant intravenous infusion of PTZ, were reduced by 30-35% in neurosteroid-withdrawing animals compared with control diestrous females. No change in threshold was observed in pseudopregnant rats treated from days 7 to 11 with finasteride, demonstrating that high levels of progesterone alone do not alter seizure reactivity.
   Conclusions: Neurosteroid withdrawal in pseudopregnant rats results in enhanced seizure susceptibility, providing an animal model of perimenstrual catamenial epilepsy that can be used for the evaluation of new therapeutic approaches.
C1 NINDS, Epilepsy Res Branch, NIH, Neuronal Excitabil Sect, Bethesda, MD 20892 USA.
   NIAAA, Lab Membrane Biochem & Biophys, NIH, Rockville, MD 20852 USA.
RP Rogawski, MA (reprint author), NINDS, Epilepsy Res Branch, NIH, Neuronal Excitabil Sect, 10 Ctr Dr,Room 5M-520 MSC 1408, Bethesda, MD 20892 USA.
RI Rogawski, Michael/B-6353-2009; 
OI Rogawski, Michael/0000-0002-3296-8193; Reddy, Samba/0000-0003-2735-9550
NR 58
TC 83
Z9 83
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD MAR
PY 2001
VL 42
IS 3
BP 328
EP 336
DI 10.1046/j.1528-1157.2001.10100.x
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA 416NC
UT WOS:000167786200007
PM 11442149
ER

PT J
AU Reddy, DS
   Rogawski, MA
AF Reddy, DS
   Rogawski, MA
TI Enhanced anticonvulsant activity of neuroactive steroids in a rat model
   of catamenial epilepsy
SO EPILEPSIA
LA English
DT Article
DE catamenial epilepsy; neurosteroid; benzodiazepam; bretazenil;
   phenobarbital; valproate
ID GAMMA-AMINOBUTYRIC-ACID; RECEPTOR ALPHA-4 SUBUNIT; MAMMALIAN
   CORTICAL-NEURONS; GABA(A) RECEPTOR; BENZODIAZEPINE RECEPTOR; ENDOCRINE
   STATES; PROGESTERONE; WITHDRAWAL; NEUROSTEROIDS; EFFICACY
AB Purpose: Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone derived neurosteroid allppregnanolone that potentiates gamma -aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition. Here we sought to determine whether the anticonvulsant potencies of neuroactive steroids, benzodiazepines, phenobarbital (PB), and valproate (VPA) are altered during the heightened seizure susceptibility accompanying neurosteroid withdrawal in a rat model of perimenstrual catamenial epilepsy.
   Methods: Test drugs were evaluated for their ability to alter the convulsant activity of pentylenetetrazol (PTZ) in young adult female rats, in pseudopregnant rats with prolonged exposure to high levels of progesterone (and its neurosteroid metabolites), and in pseudopregnant rats 24 h after acute withdrawal of neurosteroids by treatment with the 5 alpha -reductase inhibitor finasteride. Test drugs were administered at doses equivalent to twice their ED50 values for protection against PTZ-induced clonic seizures in naive young adult female rats.
   Results: The anticonvulsant activity of allopregnanolone (5 mg/kg, s.c.), pregnanolone (5 mg/kg, s.c,), allotetrahydrode-oxycorticosterone (15 mg/kg, s.c.), and tetrahydrodeoxycorticosterone (10 mg/kg, s.c.) were enhanced by 33-127% after neurosteroid withdrawal. The anticonvulsant activity of PB (65 mg/kg, i.p.) was also enhanced by 24% in neurosteroid-withdrawn animals. In contrast, the anticonvulsant activity of diazepam (4 mg/kg, i.p.), bretazenil (0.106 mg/kg, i.p.), and VPA (560 mg/kg, i.p.) were reduced or unchanged in neurosteroid-withdrawn animals.
   Conclusions: The anticonvulsant activity of neuroactive steroids is potentiated after neurosteroid withdrawal, supporting the use of such agents in the treatment of perimenstrual catamenial epilepsy.
C1 NINDS, Epilepsy Res Branch, NIH, Neuroanal Excitabil Sect, Bethesda, MD 20892 USA.
RP Rogawski, MA (reprint author), NINDS, Epilepsy Res Branch, NIH, Neuroanal Excitabil Sect, 10 Ctr Dr Room 5N-250 MSC 1408, Bethesda, MD 20892 USA.
RI Rogawski, Michael/B-6353-2009; 
OI Rogawski, Michael/0000-0002-3296-8193; Reddy, Samba/0000-0003-2735-9550
NR 41
TC 65
Z9 66
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD MAR
PY 2001
VL 42
IS 3
BP 337
EP 344
DI 10.1046/j.1528-1157.2001.10200.x
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 416NC
UT WOS:000167786200008
PM 11442150
ER

PT J
AU Minakuchi, M
   Kakazu, N
   Gorrin-Rivas, MJ
   Abe, T
   Copeland, TD
   Ueda, K
   Adachi, Y
AF Minakuchi, M
   Kakazu, N
   Gorrin-Rivas, MJ
   Abe, T
   Copeland, TD
   Ueda, K
   Adachi, Y
TI Identification and characterization of SEB, a novel protein that binds
   to the acute undifferentiated leukemia-associated protein SET
SO EUROPEAN JOURNAL OF BIOCHEMISTRY
LA English
DT Article
DE protein interaction between SET and SEB; acute undifferentiated
   leukemia; gene cloning; protein phosphatase 2A inhibitor
ID T-CELL LEUKEMIA; VIRUS TYPE-I; HEMATOPOIETIC SYSTEM CELLS; NUCLEOLAR
   TARGETING SIGNAL; OKADAIC ACID; PHOSPHATASE 2A; MESSENGER-RNA; REX
   PROTEIN; GENE; TUMOR
AB SET, the translocation breakpoint-encoded protein in acute undifferentiated leukemia (AUL), is a 39-kDa nuclear phosphoprotein and has an inhibitory activity for protein phosphatase 2A (PP2A). SET is fused to a putative oncoprotein, CAN/NUP214, in AUL and is thought to play a key role in leukemogenesis by its nuclear localization, protein-protein interactions and PP2A inhibitory activity. Here, we describe the isolation and characterization of a novel cDNA encoding a protein with 1542 amino-acid residues that specifically interacts in a yeast two-hybrid system as well as in human cells with SET. This new protein, which we name SEB (SET-binding protein), is identified as a 170-kDa protein by immunoprecipitation with a specific antibody and is localized predominantly in the nucleus. SEB1238-1434 is determined as a SET-binding region that specifically binds to SET182-223. SEB also has an oncoprotein Ski homologous region (amino acids 654-858), six PEST sequences and three sequential PPLPPPPP repeats at the C-terminus. SEB mRNA is expressed ubiquitously in all human adult tissues and cells examined. The SEB gene locus is assigned to the chromosome 18q21.1 that contains candidate tumor suppressor genes associated with deletions in cancer and leukemia. Although the function of SEB is not known, we propose that SEB plays a key role in the mechanism of SET-related leukemogenesis and tumorigenesis, perhaps by suppressing SET function or by regulating the transforming activity of Ski in the nucleus.
C1 Kyoto Univ, Inst Chem Res, Lab Mol Clin Chem, Kyoto 6110011, Japan.
   Kyoto Prefectural Univ Med, Dept Hyg, Kamigyo Ku, Kyoto 602, Japan.
   Kyoto Univ, Grad Sch Med, Dept Surg & Surg Basic Sci, Sakyo Ku, Kyoto, Japan.
   NCI, Frederick Canc Res & Dev Ctr, Frederick, MD USA.
RP Adachi, Y (reprint author), Kyoto Univ, Inst Chem Res, Lab Mol Clin Chem, Kyoto 6110011, Japan.
NR 40
TC 37
Z9 43
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0014-2956
J9 EUR J BIOCHEM
JI Eur. J. Biochem.
PD MAR
PY 2001
VL 268
IS 5
BP 1340
EP 1351
DI 10.1046/j.1432-1327.2001.02000.x
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 413GK
UT WOS:000167601900021
PM 11231286
ER

PT J
AU Grant, P
   Sharma, P
   Pant, HC
AF Grant, P
   Sharma, P
   Pant, HC
TI Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of
   neurofilament metabolism
SO EUROPEAN JOURNAL OF BIOCHEMISTRY
LA English
DT Review
DE neurofilament; Cdk5; phosphorylation; cytoskeleton; neuron
ID NEURONAL INTERMEDIATE FILAMENTS; SITE-SPECIFIC PHOSPHORYLATION; TANDEM
   MASS-SPECTROMETRY; SLOW AXONAL-TRANSPORT; GANGLION-CELL NEURONS; RAT
   SPINAL-CORD; TAIL DOMAIN; TAU-PROTEIN; CDC2-LIKE KINASE; NERVOUS-SYSTEM
AB Cyclin-dependent kinase 5 (Cdk5), a complex of Cdk5 and its activator p35 (Cdk5/p35), phosphorylates diverse substrates which have multifunctional roles in the nervous system. During development, it participates in neuronal differentiation, migration, axon outgrowth and synaptogenesis. Cdk5, acting together with other kinases, phosphorylates numerous KSPXK consensus motifs in diverse cytoskeletal protein target molecules, including neurofilaments, and microtubule associated proteins, tau and MAPs. Phosphorylation regulates the dynamic interactions of cytoskeletal proteins with one another during all aspects of neurogenesis and axon radial growth. In this review we shall focus on Cdk5 and its regulation as it modulates neurofilament metabolism in axon outgrowth, cytoskeletal stabilization and radial growth. We suggest that Cdk5/p35 forms compartmentalized macromolecular complexes of cytoskeletal substrates, other neuronal kinases, phosphatases and activators ('phosphorylation machines') which facilitate the dynamic molecular interactions that underlie these processes.
C1 NINDS, Neurochem Lab, NIH, Bethesda, MD 20892 USA.
RP Pant, HC (reprint author), NINDS, Neurochem Lab, NIH, Bldg 36 Rm 4D-04, Bethesda, MD 20892 USA.
NR 145
TC 92
Z9 95
U1 0
U2 2
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0014-2956
J9 EUR J BIOCHEM
JI Eur. J. Biochem.
PD MAR
PY 2001
VL 268
IS 6
BP 1534
EP 1546
DI 10.1046/j.1432-1327.2001.02025.x
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 415CT
UT WOS:000167703500004
PM 11248670
ER

PT J
AU Livneh, A
   Aksentijevich, I
   Langevitz, P
   Torosyna, Y
   G-Shoham, N
   Shinar, Y
   Pras, E
   Zaks, N
   Padeh, S
   Kastner, DL
   Pras, M
AF Livneh, A
   Aksentijevich, I
   Langevitz, P
   Torosyna, Y
   G-Shoham, N
   Shinar, Y
   Pras, E
   Zaks, N
   Padeh, S
   Kastner, DL
   Pras, M
TI A single mutated MEFV allele in Israeli patients suffering from familial
   Mediterranean fever and Behcet's disease (FMF-BD)
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE familial Mediterranean fever; Behcet's disease; MEFV; mutations; single
   nucleotide polymorphism; chromosome
ID GENETIC-HETEROGENEITY; ASSOCIATION; POPULATION; MUTATIONS
AB Although familial Mediterranean fever (FMF) is an autosomal recessive disorder, preliminary partial mutation analysis suggested that about 60% of FMF patients, who also suffer from Behcet's disease (FMF-BD), have only a single mutated FMF gene (MEFV). In this study, the possibility that patients with FMF-BD may indeed be carriers of a single mutated MEFV is further analysed. The presence of mutations in the coding region of MEFV of eight patients with FMF-BD, representing six families with 47 members, was determined by sequencing. A possible role for the non-carrier chromosome and for ED in the expression of FMF in patients with a single mutated MEFV allele was determined by analysing the association between these variables and the presence of FMF in heterozygous kin. Sequence analysis revealed that all eight patients had indeed only one mutation in the coding region of MEFV. The patients' non-carrier chromosomes converged into three different MEFV haplotypes and were shared by heterozygous unaffected kin in five of six families. ED was found in 10 of 11 carriers with FMF vs one of 16 carriers without FMF (P < 0.001). These results suggest that FMF may be expressed in individuals harbouring only one coding mutation in MEFV. The findings argue against a role for the non-carrier chromosome in the induction of FMF, and suggest that the FMF phenotype in this cohort, was associated with the simultaneous presence of ED. These findings may mirror a more generalised rule, that FMF may be precipitated in carriers of a single mutated FMF gene by factors unrelated to the other MEFV allele.
C1 Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
   Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   NIAMSD, Genet Sect, Arthrit & Rheumatism Branch, Bethesda, MD 20892 USA.
RP Livneh, A (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
NR 25
TC 66
Z9 67
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD MAR
PY 2001
VL 9
IS 3
BP 191
EP 196
DI 10.1038/sj.ejhg.5200608
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 417FY
UT WOS:000167825800007
PM 11313758
ER

PT J
AU Oliveri, M
   Daga, A
   Cantoni, C
   Lunardi, C
   Millo, R
   Puccetti, A
AF Oliveri, M
   Daga, A
   Cantoni, C
   Lunardi, C
   Millo, R
   Puccetti, A
TI DNase I mediates internucleosomal DNA degradation in human cells
   undergoing drug-induced apoptosis
SO EUROPEAN JOURNAL OF IMMUNOLOGY
LA English
DT Article
DE DNA fragmentation; DNase I; gene targeting; chemotherapy
ID CASPASE-ACTIVATED DNASE; HUMAN LEUKEMIC-CELLS; DEOXYRIBONUCLEASE-I;
   RECEPTOR/LIGAND SYSTEM; MOLECULAR-CLONING; DEATH; ACTIN; FRAGMENTATION;
   ENDONUCLEASE; INHIBITOR
AB Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis. DNase I, a Ca2+/Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, is believed to play a role in this process. To analyze the in vivo function of this enzyme in human cells, we have generated a cell line with targeted disruption of the DNase I gene, as well as several stable cell lines which overexpress the DNase I gene. Inactivation of the human DNase I gene was obtained in the Jurkat T cell clone JA3, characterized by high susceptibility to apoptotic cell death induced by pharmacological stimuli. JA3 cells, after disruption of the DNase I gene, became resistant to apoptotic stimuli. DNase I was overexpressed in the human cell lines JA3, K562 (erythroleukemia), M 14(melanoma) and CEM CT cell lymphoma). Remarkably, stable overexpression of DNase I gene resulted in accelerated apoptosis in JA3 cells and induced apoptosis in K562, CEM and M14 cell lines, which are otherwise resistant to internucleosomal DNA degradation following pharmacological stimuli. Our study provides the first in vivo evidence that DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis.
C1 Univ Genoa, Dept Expt Med, Genoa, Italy.
   Natl Canc Inst, IST, Genoa, Italy.
   Ist Giannina Gaslini, I-16148 Genoa, Italy.
   Univ Verona, Dept Clin & Expt Med, I-37100 Verona, Italy.
RP Puccetti, A (reprint author), Ctr Biotecnol Avanzate, Unita Citol Mol B3, Largo Rosanna Benzi I-10, I-16132 Genoa, Italy.
RI Daga, Antonio/C-3041-2008; 
OI Daga, Antonio/0000-0001-5845-8530
NR 37
TC 55
Z9 56
U1 1
U2 18
PU WILEY-V C H VERLAG GMBH
PI BERLIN
PA PO BOX 10 11 61, D-69451 BERLIN, GERMANY
SN 0014-2980
J9 EUR J IMMUNOL
JI Eur. J. Immunol.
PD MAR
PY 2001
VL 31
IS 3
BP 743
EP 751
DI 10.1002/1521-4141(200103)31:3<743::AID-IMMU743>3.0.CO;2-9
PG 9
WC Immunology
SC Immunology
GA 413KT
UT WOS:000167611900009
PM 11241278
ER

PT J
AU Castellino, F
   Han, R
   Germain, RN
AF Castellino, F
   Han, R
   Germain, RN
TI The transmembrane segment of invariant chain mediates binding to MHC
   class II molecules in a CLIP-independent manner
SO EUROPEAN JOURNAL OF IMMUNOLOGY
LA English
DT Article
DE MHC; antigen processing; biochemistry; antigen; epitope
ID COMPLEX-CLASS-II; HLA-DR MOLECULES; INTRACELLULAR-TRANSPORT; PEPTIDE
   BINDING; ENDOPLASMIC-RETICULUM; HISTOCOMPATIBILITY ANTIGENS; ENDOCYTIC
   COMPARTMENTS; SURFACE EXPRESSION; CYTOPLASMIC TAIL; MICE LACKING
AB Invariant chain (li) association with MHC class II molecules is strongly dependent upon interaction of CLIP (li exon 3, residues 81-104) with the peptide binding groove of the class II dimer. This dominant interaction does not adequately explain, however, the efficient association of ii with class II molecules of diverse allelic and isotypic origin, which have markedly different affinities for synthetic peptides corresponding to CLIP. In agreement with other recent observations, we demonstrate here that class II molecules with occupied binding sites unable to engage CLIP maintain association with ii in mild detergent. The association is direct and not mediated through unoccupied class II chains bound to properly assembled and loaded class II dimers, nor is it mediated through chaperones. The site of this CLIP-independent binding has been mapped using truncation mutants and an ii-human transferrin receptor chimeric protein to the transmembrane segment of ii. The existence of multiple low-affinity sites of interaction between MHC class II and ii helps explain how effective occupancy of all newly synthesized class II molecules can occur despite substantial variations in the strength of CLIP-dependent association that arise from class II binding domain polymorphism. These data establishing a site of II-MHC class II association N-terminal to CLIP also provide new insight into the possible functional relationship between the sequential endocytic proteolysis of ii from its C terminus and a series of contact sites with MHC class II molecules spread from the transmembrane region through to the tip of the lumenal segment of ii.
C1 NIAID, Immunol Lab, Lymphocyte Biol Sect, NIH, Bethesda, MD 20892 USA.
RP Germain, RN (reprint author), NIAID, Immunol Lab, Lymphocyte Biol Sect, NIH, Bldg 10,Rm 11N311,10 Ctr Dr,MSC-1892, Bethesda, MD 20892 USA.
NR 61
TC 27
Z9 27
U1 0
U2 0
PU WILEY-V C H VERLAG GMBH
PI BERLIN
PA PO BOX 10 11 61, D-69451 BERLIN, GERMANY
SN 0014-2980
J9 EUR J IMMUNOL
JI Eur. J. Immunol.
PD MAR
PY 2001
VL 31
IS 3
BP 841
EP 850
DI 10.1002/1521-4141(200103)31:3<841::AID-IMMU841>3.0.CO;2-D
PG 10
WC Immunology
SC Immunology
GA 413KT
UT WOS:000167611900020
PM 11241289
ER

PT J
AU Ho, B
   Crider, AM
   Stables, JP
AF Ho, B
   Crider, AM
   Stables, JP
TI Synthesis and structure-activity relationships of potential
   anticonvulsants based on 2-piperidinecarboxylic acid and related
   pharmacophores
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE 2,6-dimethylanilides; carboxamides; rotorod test; maximal electroshock
   seizure test; anticonvulsant
ID ANTIEPILEPTIC DRUGS; DERIVATIVES; ANALOGS; DESIGN
AB Using N-(2,6-dimethyl)phenyl-2-piperidinecarboxamide (1) and N-(alpha -methylbenzyl)-2-piperidinecarboxamide (2) as structural leads, a variety of analogues were synthesised and evaluated for anticonvulsant activity in the MES test in mice. In the N-benzyl series, introduction of 3-Cl, 4-Cl, 3,4-Cl-2, or 3-CF3 groups on the aromatic ring led to an increase in MES activity. Replacement of the alpha -methyl group by either i-Pr or benzyl groups enhanced MES activity with no increase in neurotoxicity. Substitution on the piperidine ring nitrogen led to a decrease in MES activity and neurotoxicity, while reduction of the amide carbonyl led to a complete loss of activity. Movement of the carboxamide group to either the 3- or 4-positions of the piperidine ring decreased MES activity and neurotoxicity. Incorporation of the piperidine ring into a tetrahydroisoquinoline or diazahydrinone nucleus led to increased neurotoxicity. In the N-(2,6-dimethyl)phenyl series, opening of the piperidine ring between the 1- and 6-positions gave the active norleucine derivative 75 (ED50 = 5.8 mg kg(-1), TD50 = 36.4 mg kg(-1), PI = 6.3). Replacement of the piperidine ring of I by cycloalkane (cyclohexane, cyclopentane, and cyclobutane) resulted in compounds with decreased MES activity and neurotoxicity, whereas replacement of the piperidine ring by a 4-pyridyl group led to a retention of MES activity with a comparable PI. Simplification of the 2-piperidinecarboxamide nucleus of 1 into a glycinecarboxamide nucleus led to about a six-fold decrease in MES activity. The 2,6-dimethylanilides were the most potent compounds in the MES test in each group of compounds evaluated, and compounds 50 and 75 should be useful leads in the development of agents for the treatment of tonic-clonic and partial seizures in man. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
C1 Univ Louisana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA.
   NINDSP, Preclin Pharmacol, Bethesda, MD 20892 USA.
RP Crider, AM (reprint author), Univ Louisana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA.
NR 39
TC 43
Z9 46
U1 0
U2 5
PU EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS CEDEX 15
PA 23 RUE LINOIS, 75724 PARIS CEDEX 15, FRANCE
SN 0223-5234
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD MAR
PY 2001
VL 36
IS 3
BP 265
EP 286
DI 10.1016/S0223-5234(00)01206-X
PG 22
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 436NP
UT WOS:000168942200007
PM 11337105
ER

PT J
AU Lebedev, MA
   Wise, SP
AF Lebedev, MA
   Wise, SP
TI Tuning for the orientation of spatial attention in dorsal premotor
   cortex
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE behavioral neurophysiology; eye movement; Macaca mulatta; reaching
   movement; saccade direction; frontal cortex
ID PRIMARY MOTOR CORTEX; PREPARATORY NEURONAL-ACTIVITY; MONKEY PRIMARY
   MOTOR; REACHING MOVEMENTS; MACAQUE MONKEY; ARM MOVEMENTS; PRIOR
   INFORMATION; VISUAL RESPONSES; FRONTAL-CORTEX; CELL-ACTIVITY
AB We tested whether neuronal activity in the dorsal premotor cortex (PMd) reflected the orientation of selective spatial attention, as opposed to the target of a reaching movement, eye position and saccade direction. These four spatial variables were dissociated in two tasks, which both required that a monkey attend to a robot's location in order to know when to make a movement. However, the target of the reaching movement varied; it was the robot's location in one task, but a different location in the other task. Eye position was recorded, but not explicitly controlled. Of 199 PMd neurons sampled, 19% had activity related to eye position, and an overlapping 11% were related to saccade direction (totaling 24% of the PMd sample). Of the 152 PMd neurons that lacked oculomotor relationships, approximate to 20% reflected the orientation of selective spatial attention. Attentional tuning may account, at least in part, for gaze-independent receptive fields and visuospatial, target or goal relationships in tasks involving stimulus-response incompatibility.
C1 NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA.
RP Lebedev, MA (reprint author), NIMH, Lab Syst Neurosci, 49 Convent Dr,Bldg 49,Room B1EE17,MSC 4401, Bethesda, MD 20892 USA.
RI Lebedev, Mikhail/H-5066-2016
OI Lebedev, Mikhail/0000-0003-0355-8723
NR 38
TC 49
Z9 50
U1 0
U2 1
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD MAR
PY 2001
VL 13
IS 5
BP 1002
EP 1008
DI 10.1046/j.0953-816x.2001.01457.x
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 413MC
UT WOS:000167615100016
PM 11264673
ER

PT J
AU Baxter, MG
   Murray, EA
AF Baxter, MG
   Murray, EA
TI Impairments in visual discrimination learning and recognition memory
   produced by neurotoxic lesions of rhinal cortex in rhesus monkeys
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE discrimination learning set; ibotenic acid; primary reinforcement;
   reversal learning
ID AUDITORY SECONDARY REINFORCEMENT; PERIRHINAL CORTEX; PARAHIPPOCAMPAL
   CORTICES; EXCITOTOXIC LESIONS; PREFRONTAL CORTEX; AMYGDALA; CONNECTIONS;
   ABLATIONS; DISRUPT; IDENTIFICATION
AB Much work on the cognitive functions of the primate rhinal (i.e. entorhinal plus perirhinal) cortex has been based on aspiration lesions of this structure, which might disrupt fibres passing nearby and through the rhinal cortex in addition to removing the cell bodies of the rhinal cortex itself. To determine whether damage limited to the cell bodies of the rhinal cortex is sufficient to impair visual learning and memory, four rhesus monkeys (Macaca mulatta) were preoperatively trained on a battery of visual learning and memory tasks, including single-pair discrimination learning for primary reinforcement, single-pair discrimination reversals, concurrent discrimination learning and reversal, and delayed matching-to-sample. Following acquisition of these tasks and a preoperative performance test, ibotenic acid was injected bilaterally into the rhinal cortex, and the monkeys were retested. Consistent with the results of studies using aspiration lesions, the monkeys were impaired on single-pair discrimination learning as well as recognition memory performance postoperatively, although reliable reversal learning impairments were not observed. The magnitude of postoperative impairment in discrimination learning was not correlated with the magnitude of postoperative impairment in recognition memory, suggesting a possible dissociation between these functions within the rhinal cortex. The correspondence of behavioural deficits following aspiration and neurotoxic lesions of the rhinal cortex validates the attribution of various cognitive functions to this structure, based on the results of studies with aspiration lesions.
C1 NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA.
   Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
RP Murray, EA (reprint author), NIMH, Neuropsychol Lab, 49 Convent Dr, Bethesda, MD 20892 USA.
OI Murray, Elisabeth/0000-0003-1450-1642
NR 38
TC 43
Z9 43
U1 1
U2 2
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD MAR
PY 2001
VL 13
IS 6
BP 1228
EP 1238
DI 10.1046/j.0953-816x.2001.01491.x
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 413MF
UT WOS:000167615400018
PM 11285020
ER

PT J
AU Warner, HR
AF Warner, HR
TI Support for basic gerontological research in the USA
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE basic gerontological research; priority areas; molecular mechanisms of
   aging
ID GENE-EXPRESSION PROFILE; LIFE-SPAN; CAENORHABDITIS-ELEGANS; CALORIE
   RESTRICTION; LONGEVITY; MICE; EXTENSION; DIAPAUSE; BIOLOGY; PROTEIN
AB Support for research in basic gerontology in the United States of America is briefly described. The support mechanisms, how to apply for a grant, and priority areas of research are outlined, and recent progress in a few of these priority areas is discussed. In general, government support for biogerontology research has been generous, and as a result considerable progress has been made in understanding the molecular mechanisms of aging in animal model systems. Translation of these findings to humans, and development of interventions to promote healthy aging in humans remain an unfulfilled priority, but new knowledge and development of better technologies and model systems suggest an optimistic future. Published by Elsevier Science Inc.
C1 NIA, Biol Aging Program, Bethesda, MD 20892 USA.
RP Warner, HR (reprint author), NIA, Biol Aging Program, Suite 2C231,7201 Wisconsin Ave,Gateway Bldg, Bethesda, MD 20892 USA.
NR 33
TC 1
Z9 1
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAR
PY 2001
VL 36
IS 3
BP 403
EP 412
DI 10.1016/S0531-5565(00)00261-8
PG 10
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA 412BG
UT WOS:000167533700002
PM 11250113
ER

PT J
AU Hamilton, JF
   Morrison, PF
   Chen, MY
   Harvey-White, J
   Pernaute, RS
   Phillips, H
   Oldfield, E
   Bankiewicz, KS
AF Hamilton, JF
   Morrison, PF
   Chen, MY
   Harvey-White, J
   Pernaute, RS
   Phillips, H
   Oldfield, E
   Bankiewicz, KS
TI Heparin coinfusion during convection-enhanced delivery (CED) increases
   the distribution of the glial-derived neurotrophic factor (GDNF) ligand
   family in rat striatum and enhances the pharmacological activity of
   neurturin
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE heparin; trophic factor; convection-enhanced drug delivery
ID FIBROBLAST GROWTH-FACTOR; MIDBRAIN DOPAMINERGIC-NEURONS; IN-VIVO;
   ALZHEIMERS-DISEASE; INFUSION; BRAIN; AFFINITY; BINDING; CELLS;
   STIMULATION
AB Convection-enhanced delivery (CED) distributes macromolecules in the brain in a homogeneous, targeted fashion in clinically useful volumes. However, the binding of growth factors to heparin-binding sites in the extracellular matrix may limit the volume of distribution (V-d). To overcome this limitation, we examined the effects of heparin coinfusion on V-d of glial-derived neurotrophic factor (GDNF), neurturin (NTN), artemin, and a nonspecifically bound protein, albumin. Heparin coinfusion significantly enhanced the Vd of GDNF and GDNF-homologous trophic factors, probably by binding and blocking heparin-binding sites in the extracellular matrix. Furthermore, coinfusion of heparin with NTN enhanced striatal dopamine metabolism, compared to trophic factor administered alone. The negligible benefit of GDNF in recent clinical trials of Parkinson's disease may result from limited tissue distribution. Heparin coinfusion during CED targeting the striatum may alleviate this important limitation. This study demonstrates the influence of receptor binding on the distribution of trophic factors in the CNS. (C) 2001 Academic Press.
C1 NINDS, Mol Therapeut Sect, LMMN, NIH, Bethesda, MD 20892 USA.
   NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
   NINDS, Biomed Engn & Instrumentat Program, NIH, Bethesda, MD 20892 USA.
   Genentech Inc, San Francisco, CA 94080 USA.
RP Bankiewicz, KS (reprint author), NINDS, Mol Therapeut Sect, LMMN, NIH, Bldg 36,Room 5W21, Bethesda, MD 20892 USA.
RI Kipke, Daryl/A-2167-2009
NR 32
TC 97
Z9 100
U1 0
U2 2
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD MAR
PY 2001
VL 168
IS 1
BP 155
EP 161
DI 10.1006/exnr.2000.7571
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 406ER
UT WOS:000167202400014
PM 11170730
ER

PT J
AU Zogakis, TG
   Libutti, SK
AF Zogakis, TG
   Libutti, SK
TI General aspects of anti-angiogenesis and cancer therapy
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE angiogenesis; cancer therapy; carboxyamido-triazole; endostatin; IL-12;
   matrix metalloproteinases; suramin; thalidomide; VEGF
ID ENDOTHELIAL GROWTH-FACTOR; MATRIX-METALLOPROTEINASE INHIBITOR; PHASE-II
   TRIAL; RECOMBINANT HUMAN INTERLEUKIN-12; DOMAIN-CONTAINING RECEPTOR;
   CALCIUM INFLUX INHIBITOR; CHEMICALLY-MODIFIED TETRACYCLINES; INDEPENDENT
   PROSTATE-CANCER; METASTATIC BREAST-CANCER; HUMAN COLORECTAL-CANCER
AB Angiogenesis is the outgrowth of new vessels from pre-existing ones. Tumour growth and metastasis is dependent on angiogenesis and many stimulatory and inhibitory factors have been described which play an active role in this process. Inhibition of tumour neovasculature may be one strategy to inhibit tumour growth. Naturally occurring inhibitors of angiogenesis have been discovered and synthetic agents have been designed. Many of these inhibitors are currently being evaluated in clinical trials for the treatment of cancer. This review discusses the mechanism of action of these anti-angiogenics as well as a description of the clinical trials in which they are being evaluated.
C1 NCI, Surg Branch, Bethesda, MD 20892 USA.
RP Libutti, SK (reprint author), NCI, Surg Branch, 10-2B1710 Ctr Dr, Bethesda, MD 20892 USA.
NR 192
TC 32
Z9 37
U1 0
U2 2
PU ASHLEY PUBLICATIONS LTD
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE FINCHLEY CENTRAL, LONDON N3 1QB,
   ENGLAND
SN 1471-2598
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD MAR
PY 2001
VL 1
IS 2
BP 253
EP 275
DI 10.1517/14712598.1.2.253
PG 23
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 493XW
UT WOS:000172249600009
PM 11727534
ER

PT J
AU Wang, E
   Phan, GQ
   Marincola, FM
AF Wang, E
   Phan, GQ
   Marincola, FM
TI T-cell-directed cancer vaccines: the melanoma model
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE immune monitoring; immunotherapy; melanoma; neoplasm; T-lymphocyte;
   vaccines
ID TUMOR-INFILTRATING LYMPHOCYTES; PULSED DENDRITIC CELLS; GENE-EXPRESSION
   PATTERNS; IN-VITRO STIMULATION; MHC CLASS-I; DIFFERENTIATION ANTIGEN
   EXPRESSION; METASTATIC MELANOMA; PERIPHERAL-BLOOD; ANTITUMOR IMMUNITY;
   MOLECULAR CLASSIFICATION
AB Significant advances in the understanding of the molecular basis for tumour/host interactions in humans have occurred in the last decade through studying patients with metastatic melanoma. This disease is characterised by its tendency to be modulated by immunologic factors. Furthermore, immunologic manipulation of the host with various systemic agents, in particular IL-2, frequently affects this natural phenomenon and can lead to complete rejection of cancer. By studying the cellular immunology occurring in patients undergoing immunotherapy, several tumour antigens (TA) and their epitopes recognised by human leukocyte antigen (HLA) class I-restricted cytotoxic T-lymphocytes (CTL) have been identified. Most of these TA are non-mutated molecules expressed by the majority of melanoma in vivo and most melanoma cell lines. In addition, unique minimal epitopic sequences play an immunodominant role in the context of specific HLA class I alleles. Since melanoma lesions from different patients often share expression of the same TA, and a minimal peptide sequence from a TA can cause immunologic changes in multiple patients, interest has grown in the development of TA-specific vaccines suitable for broad patient populations. Repeated in vitro stimulation of peripheral blood mononuclear cells (PBMC) with TA-derived epitopes can induce a high frequency of TA-reactive T-cells in melanoma patients. The same epitopes can also enhance TA-specific T-cell reactivity in vivo when administered subcutaneously in combination with Incomplete Freund's Adjuvant (IFA). Epitope-based vaccinations, however, have not shown strong clinical efficacy unless combined with IL-2 administration. Attempts to increase the efficacy of these vaccines have combined specialised antigen-presenting cells or the administration of whole TA through DNA- or RNA-based vaccines with the intention of increasing antigen presentation and processing. Save for scattered reports, however, the success of these approaches has been limited and T-cell-directed vaccination against cancer remains at a paradoxical standstill whereby anticancer immunisation can be induced but it is not sufficient, in most cases, to induce tumour regression. Using melanoma as the standard model for immunotherapy, we will review various methods of T-cell-directed vaccination, the monitoring and analysis of the resulting immune response, and several clinical trials in which cancer vaccines have successfully induced immunisation.
C1 NIH, NCI, Surg Branch, Bethesda, MD 20892 USA.
RP Marincola, FM (reprint author), NIH, NCI, Surg Branch, Bldg 10,Rm 2B42,9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 109
TC 40
Z9 40
U1 0
U2 0
PU ASHLEY PUBLICATIONS LTD
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE FINCHLEY CENTRAL, LONDON N3 1QB,
   ENGLAND
SN 1471-2598
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD MAR
PY 2001
VL 1
IS 2
BP 277
EP 290
DI 10.1517/14712598.1.2.277
PG 14
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 493XW
UT WOS:000172249600010
PM 11727535
ER

PT J
AU Rohrbaugh, MJ
   Shoham, V
   Trost, S
   Muramoto, M
   Cate, RM
   Leischow, S
AF Rohrbaugh, MJ
   Shoham, V
   Trost, S
   Muramoto, M
   Cate, RM
   Leischow, S
TI Couple dynamics of change-resistant smoking: Toward a family
   consultation model
SO FAMILY PROCESS
LA English
DT Article
ID INTERRUPTING IRONIC PROCESSES; SOCIAL SUPPORT; BRIEF THERAPY; CESSATION;
   INTERVENTIONS; NICOTINE; HEALTH; ALCOHOLISM; BEHAVIORS; PERSPECTIVE
AB Smoking is North America's leading cause of preventable morbidity and mortality. Although effective cessation treatments exist, their overall effect is modest, and they rarely reach the high-P ish, health-compromised smokers who need them most. Surprisingly, despite evidence that marital relationship variables predict the success of cessation efforts, family systems ideas have had little impact on current intervention research. We review and critique the cessation literature from a systemic viewpoint, illustrate two couple-interaction patterns relevant to the maintenance of high-risk smoking, and outline a family-consultation (FAMCON) intervention for couples in which at least one partner continues to smoke despite having heart or lung disease. Taking into account ironic processes and symptom-system fit, FAMCON focuses on the immediate social context of smoking, aiming to interrupt well-intentioned "solutions" that ironically feed back to keep smoking going, and to help clients realign important relationships in ways not organized around tobacco usage. Currently in its pilot-testing phase, FAMCON is an adjunctive, complementary approach designed to include collaboration with primary-care physicians and to make smokers more amenable to other, evidence-based cessation strategies.
C1 Univ Arizona, Dept Psychol, Family Res Lab, Tucson, AZ 85721 USA.
   Univ Arizona, Dept Family & Community Med, Tucson, AZ USA.
   Univ Arizona, Arizona Program Nicotine & Tobacco Res, Tucson, AZ USA.
   Univ Arizona, Div Family Studies & Human Dev, Sch Family & Consumer Sci, Tucson, AZ USA.
   NCI, Tobacco Control Res Branch, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
RP Rohrbaugh, MJ (reprint author), Univ Arizona, Dept Psychol, Family Res Lab, Tucson, AZ 85721 USA.
EM michaelr@u.arizona.edu
RI Reis, Aline/G-9573-2012
FU NIDA NIH HHS [R21 DA013121, R21 DA013121-03, R21-DA13121]
NR 64
TC 24
Z9 25
U1 3
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-7370
J9 FAM PROCESS
JI Fam. Process
PD SPR
PY 2001
VL 40
IS 1
BP 15
EP 31
DI 10.1111/j.1545-5300.2001.4010100015.x
PG 17
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA 413MX
UT WOS:000167616900003
PM 11288367
ER

PT J
AU Lee, J
   Han, KC
   Lee, SY
   Kim, SY
   Kang, JH
   Lewin, NE
   Best, LS
   Blumberg, PM
   Marquez, VE
AF Lee, J
   Han, KC
   Lee, SY
   Kim, SY
   Kang, JH
   Lewin, NE
   Best, LS
   Blumberg, PM
   Marquez, VE
TI 5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel
   template for protein kinase C (PKC) binding
SO FARMACO
LA English
DT Article
DE protein kinase C; phorbol ester; pharmacophore model;
   diacylglycerol-lactones; PKC ligands
ID CONFORMATIONALLY CONSTRAINED ANALOGS; PHORBOL ESTER-BINDING; TUMOR
   PROMOTERS; DIACYLGLYCEROL; RECEPTOR; AFFINITY; LIGANDS; DESIGN; MODEL
AB A series of alkyl tetrahydrofuran-2-carboxylates (1-4) bearing a new set of three pharmacophoric groups were tested as protein kinase C (PKC) ligands. The compounds were synthesized from commercially available glycidyl 4-methoxyphenyl ether. The correlation between their binding affinities for PKC-alpha and a conformational fit to phorbol ester indicates they mimic a pharmacophore model comprising the C-20-OH, C-3-C=O and C-9-OH rather than that including the C-13-C=O moiety. (C) 2001 Elsevier Science S.A. All rights reserved.
C1 Seoul Natl Univ, Coll Pharm, Med Chem Lab, Seoul 151742, South Korea.
   NCI, Cellular Carcinogenesis & Tumor Promot Lab, NIH, Bethesda, MD 20892 USA.
   NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA.
RP Lee, J (reprint author), Seoul Natl Univ, Coll Pharm, Med Chem Lab, Seoul 151742, South Korea.
NR 21
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0014-827X
J9 FARMACO
JI Farmaco
PD MAR
PY 2001
VL 56
IS 3
BP 203
EP 210
AR PII S0014-827X(01)01077-1
DI 10.1016/S0014-827X(01)01077-1
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 586HX
UT WOS:000177579500008
PM 11409328
ER

PT J
AU Fessele, S
   Boehlk, S
   Mojaat, A
   Miyamoto, NG
   Werner, T
   Nelson, EL
   Schlondorff, D
   Nelson, PJ
AF Fessele, S
   Boehlk, S
   Mojaat, A
   Miyamoto, NG
   Werner, T
   Nelson, EL
   Schlondorff, D
   Nelson, PJ
TI Molecular and in silico characterization of a promoter module and C/EBP
   element that mediate LPS-induced RANTES/CCL5 expression in monocytic
   cells
SO FASEB JOURNAL
LA English
DT Article
C1 Univ Munich, Klinikum Innenstadt, Med Poliklin, D-8000 Munich, Germany.
   Beriex Biosci, Dept Immunol, Richmond, CA USA.
   GSF, Natl Res Ctr Environm & Hlth, Inst Mammalian Genet, Neuherberg, Germany.
   Genomatix Software GmbH, Munich, Germany.
   NCI, Frederick Canc Res & Dev Ctr, Frederick, MD USA.
RP Nelson, PJ (reprint author), Univ Munich, Med Poliklin, Schillerstr 42, D-80336 Munich, Germany.
OI Fessele, Sabine/0000-0002-5399-3574
NR 0
TC 46
Z9 46
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR
PY 2001
VL 15
IS 3
BP 577
EP 579
PG 3
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 410BE
UT WOS:000167419500010
PM 11259372
ER

PT J
AU Kruth, HS
AF Kruth, HS
TI Macrophage foam cells and atherosclerosis
SO FRONTIERS IN BIOSCIENCE
LA English
DT Review
DE atherosclerosis; cholesterol; lipoproteins; macrophage; vessels; lipids;
   metabolism; review
ID LOW-DENSITY-LIPOPROTEIN; MONOCYTE-DERIVED MACROPHAGES; MOUSE
   PERITONEAL-MACROPHAGES; CHOLESTERYL ESTER ACCUMULATION;
   TRIGLYCERIDE-RICH LIPOPROTEINS; ACYL-COENZYME-A; RECEPTOR-RELATED
   PROTEIN; SMOOTH-MUSCLE CELLS; INTRACELLULAR LIPID-ACCUMULATION;
   SURFACE-CONNECTED COMPARTMENTS
AB Focal buildup of cholesterol in arteries is the process that produces atherosclerotic plaques, the cause of most coronary artery disease and strokes. Monocyte-derived macrophages are central cells that accumulate this cholesterol in atherosclerotic lesions, a manifestation of the scavenging function of the macrophage. Different types of cholesterol-containing lipid particles found in atherosclerotic lesions may enter macrophages by a variety of endocytic pathways. The fate of cholesterol that enters macrophages determines whether macrophages help or hinder cholesterol removal from the vessel wall. Macrophages may function to carry cholesterol out of lesions, or to process the cholesterol for excretion in association with small protein-phospholipid complexes. Alternatively, macrophages that do not efficiently function to remove cholesterol from lesions may ultimately undergo cell death. Some cytokines, hormones, and pharmacologic agents show potential to modulate these processes and may be useful in directing macrophage function in atherosclerotic lesions towards beneficial rather than harmful effects.
C1 NHLBI, Sect Expt Atherosclerosis, NIH, Bethesda, MD 20892 USA.
RP Kruth, HS (reprint author), NHLBI, Sect Expt Atherosclerosis, NIH, Bldg 10,Room 5N-113,10 Ctr Dr MSC 1422, Bethesda, MD 20892 USA.
NR 338
TC 47
Z9 50
U1 2
U2 5
PU FRONTIERS IN BIOSCIENCE INC
PI MANHASSET
PA C/O NORTH SHORE UNIV HOSPITAL, BIOMEDICAL RESEARCH CENTER, 350 COMMUNITY
   DR, MANHASSET, NY 11030 USA
SN 1093-9946
J9 FRONT BIOSCI
JI Front. Biosci.
PD MAR
PY 2001
VL 6
BP D429
EP D455
DI 10.2741/Kruth
PG 27
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 409AC
UT WOS:000167361500009
PM 11229875
ER

PT J
AU Doo, E
   Liang, TJ
AF Doo, E
   Liang, TJ
TI Molecular anatomy and pathophysiologic implications of drug resistance
   in hepatitis B virus infection
SO GASTROENTEROLOGY
LA English
DT Review
ID TYPE-1 REVERSE-TRANSCRIPTASE; LAMIVUDINE THERAPY; ANGSTROM RESOLUTION;
   CARBOXYPEPTIDASE-D; STERIC HINDRANCE; POLYMERASE GENE; 3TC RESISTANCE;
   DNA-SYNTHESIS; IN-VIVO; MUTATIONS
AB Synthesis of the hepatitis B virus (HBV) DNA genome occurs within the viral nucleocapsid in a mechanistically ordered fashion. The nucleocapsid contains small pores that permit influx of nucleotide triphosphates and metabolites of nucleoside analogues such as lamivudine for DNA synthesis. Lamivudine is a potent inhibitor of HBV and human immunodeficiency virus (HIV) reverse transcriptases, but substitutions of isoleucine or valine for methionine within the tyrosine-methionine-aspartate-aspartate (YMDD) motif are associated with virologic and clinical resistance to lamivudine therapy. Under lamivudine selection pressure, the high viral production rate and the low fidelity viral polymerase contribute to frequent development of the YMDD mutants. However, the pattern and dynamics of emergence of the mutant viruses over the wild-type virus are determined by multiple factors including replication efficiency, host immune response, and availability of replication space. Structural modeling of HIV reverse transcriptase has permitted key insights into the molecular basis of lamivudine resistance of HBV based on evolutionary relatedness of HIV and HBV, The side groups of isoleucine and valine of the YMDD mutants sterically prevent lamivudine from appropriately configuring into the nucleotide binding site of the reverse transcriptase, Aminotransferase flares are associated with lamivudine therapy and may signify clinical resistance with emergence of YMDD mutants. They may also herald the recovery phase with seroconversion and viral clearance, Reconstitution of the endogenous anti-HBV immune response may be equally important in the control of viral replication by lamivudine and other nucleoside analogues.
C1 NIDDKD, Liver Dis Sect, NIH, Bethesda, MD 20892 USA.
RP Liang, TJ (reprint author), NIDDKD, Liver Dis Sect, NIH, Bldg 10,Room 9B-17,10 Ctr Dr, Bethesda, MD 20892 USA.
NR 55
TC 68
Z9 76
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAR
PY 2001
VL 120
IS 4
BP 1000
EP 1008
DI 10.1053/gast.2001.22454
PG 9
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 407ZP
UT WOS:000167302300030
PM 11231955
ER

PT J
AU Balsara, BR
   Pei, JM
   De Rienzo, A
   Simon, D
   Tosolini, A
   Lu, YY
   Shen, FM
   Fan, XL
   Lin, WY
   Buetow, KH
   London, WT
   Testa, JR
AF Balsara, BR
   Pei, JM
   De Rienzo, A
   Simon, D
   Tosolini, A
   Lu, YY
   Shen, FM
   Fan, XL
   Lin, WY
   Buetow, KH
   London, WT
   Testa, JR
TI Human hepatocellular carcinoma is characterized by a highly consistent
   pattern of genomic imbalances, including frequent loss of 16q23.1-24.1
SO GENES CHROMOSOMES & CANCER
LA English
DT Article
ID HEPATITIS-B VIRUS; HYBRIDIZATION ANALYSIS; CHROMOSOME 16Q;
   GROWTH-FACTOR; HETEROZYGOSITY; DNA; AMPLIFICATION; GENE; IDENTIFICATION;
   INSTABILITY
AB Comparative genomic hybridization (CGH) analysis was used to identify chromosomal imbalances in 52 human primary hepatocellular carcinomas (HCCs). The most prominent changes were gains of part or all of chromosome arms 8q (83% of cases) and 1q (73%) and loss of 16q (63%). Other commonly overrepresented sites were 5p, 7q, and Xq. Recurrent sites of DNA sequence amplification included 8q23-24 (five cases) and 11q13-14 (four cases). Other frequently underrepresented sites were 4q, 8p, 16p, and 17p. Taken collectively, these findings and data from other CGH studies of HCCs define a subset of chromosome segments that are consistently over- or underrepresented and highlight sites of putative oncogenes and tumor suppressor genes, respectively, involved in hepatocellular oncogenesis. Loss of heterozygosity analysis with a panel of polymorphic microsatellite markers distributed along 16q defined a minimal region of chromosomal loss at 16q23.1-24.1, suggesting that this region harbors a tumor suppressor gene whose loss/inactivation may contribute to the pathogenesis of many HCCs. (C) 2001 Wiley-Liss, Inc.
C1 Fox Chase Canc Ctr, Div Populat Sci, Human Genet Program, Philadelphia, PA 19111 USA.
   MCP Hahnemann Sch Med, Philadelphia, PA USA.
   Beijing Inst Canc Res, Dept Biochem & Mol Biol, Beijing, Peoples R China.
   Shanghai Med Univ, Dept Epidemiol, Shanghai 200032, Peoples R China.
   Haimen City Canc Prevent Inst, Haimen, Peoples R China.
   NCI, Lab Populat Genet, Bethesda, MD 20892 USA.
RP Testa, JR (reprint author), Fox Chase Canc Ctr, Div Populat Sci, Human Genet Program, 7701 Burholme Ave, Philadelphia, PA 19111 USA.
FU NCI NIH HHS [U19CA40737, CA-06927]
NR 46
TC 54
Z9 56
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 1045-2257
J9 GENE CHROMOSOME CANC
JI Gene Chromosomes Cancer
PD MAR
PY 2001
VL 30
IS 3
BP 245
EP 253
DI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1083>3.0.CO;2-M
PG 9
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA 400BT
UT WOS:000166849300004
PM 11170281
ER

PT J
AU Fang, Y
   Guan, XY
   Guo, Y
   Sham, JST
   Deng, MQ
   Liang, QW
   Li, HM
   Zhang, HG
   Zhou, H
   Trent, J
AF Fang, Y
   Guan, XY
   Guo, Y
   Sham, JST
   Deng, MQ
   Liang, QW
   Li, HM
   Zhang, HG
   Zhou, H
   Trent, J
TI Analysis of genetic alterations in primary nasopharyngeal carcinoma by
   comparative genomic hybridization
SO GENES CHROMOSOMES & CANCER
LA English
DT Article
ID CHROMOSOME ARM 16Q; HUMAN SARCOMAS; BREAST-CANCER; HETEROZYGOSITY;
   REGION; AMPLIFICATION; MDM2; IDENTIFICATION; ABERRATIONS; TUMORS
AB To identify genetic alterations associated with the development. and progression of human nasopharyngeal carcinoma (NPC), 57 tumors were analyzed by comparative genomic hybridization (CGH). In 47 cases, chromosomal imbalances were found. Several recurrent chromosomal abnormalities were identified in the present study. The most frequently detected chromosomal gains involved chromosome arms 12q (24 cases, 51%), 4q (17 cases, 36%), 3q (16 cases, 34%), 1q (15 cases, 32%), and 18q (15 cases, 32%). Common regions of gain involved 12q13-q15, 4q12-q21, and 3q21-q26. High-copy-number increases of chromosomal materials were detected in four chromosomal regions, 3q21-q26.2, 4p12-q21, 8p, and 12q14-q15. The most frequently detected loss of chromosomal materials involved chromosome arms 16q (26 cases, 55%), 14q (21 cases, 45%), 1p (20 cases, 43%), 3p (20 cases, 43%), 16p (19 cases. 40%), 1 Iq (17 cases, 36%), and 19p (16 cases, 34%). The most common regions of loss involved 14q24-qter, 1 pter-p36.1, 3p22-p21.3, 11q21-qter, and the distal region of 19p. Genomic alterations detected by CGH were compared and found to be largely consistent with those identified in banding analysis and loss of heterozygosity studies. However, several previously unrecognized recurrent alterations were also identified in the present study, including gain of 4q and 18q, and loss of 16q, 14q, and 19p. In addition, gain of 1q, 8q, 18q, and loss of 9q showed a statistically significant association with advanced clinical stages (P < 0.05). Identification of recurrent sites of chromosomal gain and loss identify regions of the genome that may contain oncogenes or tumor suppressor genes, respectively, which may be involved in the tumorigenesis of NPC. Published 2001 Wiley-Liss, Inc(<dagger>).
C1 NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
   Sun Yat Sen Univ Med Sci, Ctr Canc, Guangzhou, Peoples R China.
   Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China.
RP Trent, J (reprint author), NHGRI, Canc Genet Branch, NIH, 49 Convent Dr MSC 4470,Rm 4A22, Bethesda, MD 20892 USA.
RI Guan, Xin-Yuan/A-3639-2009
OI Guan, Xin-Yuan/0000-0002-4485-6017
NR 26
TC 80
Z9 99
U1 0
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 1045-2257
J9 GENE CHROMOSOME CANC
JI Gene Chromosomes Cancer
PD MAR
PY 2001
VL 30
IS 3
BP 254
EP 260
DI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1086>3.0.CO;2-D
PG 7
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA 400BT
UT WOS:000166849300005
PM 11170282
ER

PT J
AU Kovalchuk, AL
   Esa, A
   Coleman, AE
   Park, SS
   Ried, T
   Cremer, CC
   Janz, S
AF Kovalchuk, AL
   Esa, A
   Coleman, AE
   Park, SS
   Ried, T
   Cremer, CC
   Janz, S
TI Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610
SO GENES CHROMOSOMES & CANCER
LA English
DT Article
ID C-MYC; CHROMOSOMAL TRANSLOCATIONS; MURINE PLASMACYTOMAS; MOUSE
   PLASMACYTOMAS; RECOMBINATIONS; CELLS; MICE; ABERRATIONS; ALPHA
AB Myc-activating chromosomal 12:15 translocations, the hallmark mutations of inflammation-induced BALB/c plasmacytomas, have recently been shown to undergo remodeling by isotype switch-like generic recombinations that remove similar to 180 kb of immunoglobulin heavy-chain sequence in the vicinity of the rearranged, expressed Myc gene. Here we combine cytogenetic data on the 12;15 translocation (SKY and FISH) with the molecular analysis of key junction sites (long-range PCR followed by DNA sequencing) to demonstrate that translocation remodeling occurred as an infrequent, stepwise, and disomic tumor progression event in the tetraploid, fully transformed, and transplantable plasmacytoma TEPC 3610. This result was used. in conjunction with previously obtained molecular data on five other primary plasmacytomas, to devise a hypothesis that predicts that the selective pressure to undergo translocation remodeling may be predetermined by the location of the break site in Myc. The pressure may be low if the break occurs 5' of the normal promoter region of Myc, but it may be considerably stronger if the break occurs 3' of the Myc promoter. Published 2001 Wiley-Liss, Inc(dagger).
C1 NCI, Genet Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA.
   NCI, Dept Genet, Div Clin Sci, NIH, Bethesda, MD 20892 USA.
   Univ Heidelberg, Inst Appl Phys, Heidelberg, Germany.
RP Janz, S (reprint author), NCI, Genet Lab, Div Basic Sci, NIH, Bldg 37,Room 2B10, Bethesda, MD 20892 USA.
NR 17
TC 8
Z9 8
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 1045-2257
J9 GENE CHROMOSOME CANC
JI Gene Chromosomes Cancer
PD MAR
PY 2001
VL 30
IS 3
BP 283
EP 291
DI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1094>3.0.CO;2-I
PG 9
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA 400BT
UT WOS:000166849300009
PM 11170286
ER

PT J
AU Marinissen, MT
   Chiariello, M
   Gutkind, JS
AF Marinissen, MT
   Chiariello, M
   Gutkind, JS
TI Regulation of gene expression by the small GTPase Rho through the ERK6
   (p38 gamma) MAP kinase pathway
SO GENES & DEVELOPMENT
LA English
DT Review
DE RhoA; ERK6 (p38 gamma); c-jun; signal transduction; MAP kinase; GTPase
ID C-JUN PROMOTER; SIGNAL-TRANSDUCTION PATHWAY; ACTIVATED PROTEIN-KINASES;
   SERINE-THREONINE KINASE; SERUM RESPONSE ELEMENT; CELL-CYCLE PROGRESSION;
   ACTIN STRESS FIBERS; TRANSCRIPTION FACTOR; BINDING PROTEIN;
   SACCHAROMYCES-CEREVISIAE
AB Small GTP-binding proteins of the Rho-family, Rho, pac, and Cdc42, have been traditionally linked to the regulation of the cellular actin-based cytoskeleton. Rac and Cdc42 can also control the activity of INK, thus acting in a molecular pathway transmitting extracellular signals to the nucleus. Interestingly, Rho can also regulate gene expression, albeit by a not fully understood mechanism. Here, we found that activated RhoA can stimulate c-jun expression and the activity of the c-jun promoter. As the complexity of the signaling pathways controlling the expression of c-jun has begun to be unraveled, this finding provided a unique opportunity to elucidate the biochemical routes whereby RhoA regulates nuclear events. We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 (p38 gamma), a recently identified member of the p38 family of MAPKs. Furthermore, we present evidence that RhoA, PKN, MKK3/MKK6, and ERK6 (p38 gamma) are components of a novel signal transduction pathway involved in the regulation of gene expression and cellular transformation.
C1 NIDCR, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
RP Gutkind, JS (reprint author), NIDCR, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
RI Gutkind, J. Silvio/A-1053-2009; Chiariello, Mario/O-3642-2014
OI Chiariello, Mario/0000-0001-8434-5177
NR 104
TC 131
Z9 135
U1 0
U2 8
PU COLD SPRING HARBOR LAB PRESS
PI PLAINVIEW
PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 USA
SN 0890-9369
J9 GENE DEV
JI Genes Dev.
PD MAR 1
PY 2001
VL 15
IS 5
BP 535
EP 553
DI 10.1101/gad.855801
PG 19
WC Cell Biology; Developmental Biology; Genetics & Heredity
SC Cell Biology; Developmental Biology; Genetics & Heredity
GA 410AZ
UT WOS:000167419000005
PM 11238375
ER

PT J
AU Allen, DR
   van Praag, H
   Ray, J
   Weaver, Z
   Winrow, CJ
   Carter, TA
   Braquet, R
   Harrington, E
   Ried, T
   Brown, KD
   Gage, FH
   Barlow, C
AF Allen, DR
   van Praag, H
   Ray, J
   Weaver, Z
   Winrow, CJ
   Carter, TA
   Braquet, R
   Harrington, E
   Ried, T
   Brown, KD
   Gage, FH
   Barlow, C
TI Ataxia telangiectasia mutated is essential during adult neurogenesis
SO GENES & DEVELOPMENT
LA English
DT Article
DE neural progenitor; DNA repair; neuron; oligodendrocyte; astrocyte;
   running
ID ATM-DEPENDENT PHOSPHORYLATION; CENTRAL-NERVOUS-SYSTEM; DOUBLE-STRAND
   BREAKS; NEURAL STEM-CELLS; DNA-LIGASE-IV; GENE-PRODUCT; DEFICIENT MICE;
   DENTATE GYRUS; S-PHASE; PROTEIN
AB Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein kinase implicated in cell cycle regulation and DNA repair. The role of ATM in the brain and the consequences of its loss on neuronal survival remain unclear. We studied the role of ATM in adult neural progenitor cells in vivo and in vitro to define the role of ATM in dividing and postmitotic neural cells from Atm-deficient (Atm(-/-)) mice in a physiologic context. We demonstrate that ATM is an abundant protein in dividing neural progenitor cells but is markedly down-regulated as cells differentiate. In the absence of ATM, neural progenitor cells of the dentate gyrus show abnormally high rates of proliferation and genomic instability. Atm(-/-) cells in vivo, and in cell culture, show a blunted response to environmental stimuli that promote neural progenitor cell proliferation, survival, and differentiation along a neuronal lineage. This study defines a role for ATM during the process of neurogenesis, demonstrates that ATM is required for normal cell fate determination and neuronal survival both in vitro and in vivo, and points to a mechanism for neuronal cell loss in progressive neurodegenerative diseases.
C1 Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.
   NCI, Dept Genet, Div Clin Sci, NIH, Bethesda, MD 20892 USA.
   Louisiana State Univ, Med Ctr, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA.
   Louisiana State Univ, Med Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70112 USA.
   Massachusetts Gen Hosp, Mol Oncol Lab, Charlestown, MA 01029 USA.
RP Barlow, C (reprint author), Salk Inst Biol Studies, Genet Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.
RI Winrow, Christopher/K-1864-2014; van Praag, Henriette/F-3939-2015
OI van Praag, Henriette/0000-0002-5727-434X
FU NINDS NIH HHS [N01-NS-6-2348]; PHS HHS [A606088]
NR 45
TC 116
Z9 121
U1 0
U2 0
PU COLD SPRING HARBOR LAB PRESS
PI PLAINVIEW
PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 USA
SN 0890-9369
J9 GENE DEV
JI Genes Dev.
PD MAR 1
PY 2001
VL 15
IS 5
BP 554
EP 566
DI 10.1101/gad.869001
PG 13
WC Cell Biology; Developmental Biology; Genetics & Heredity
SC Cell Biology; Developmental Biology; Genetics & Heredity
GA 410AZ
UT WOS:000167419000006
PM 11238376
ER

PT J
AU Zhou, YN
   Gottesman, S
   Hoskins, JR
   Maurizi, MR
   Wickner, S
AF Zhou, YN
   Gottesman, S
   Hoskins, JR
   Maurizi, MR
   Wickner, S
TI The RssB response regulator directly targets sigma(S) for degradation by
   ClpXP
SO GENES & DEVELOPMENT
LA English
DT Article
DE ATP-dependent proteolysis; molecular chaperones; ClpA; RpoS; sigma S;
   acetyl phosphate
ID SUBUNIT-SPECIFIC DEGRADATION; ATP-DEPENDENT PROTEASES; ESCHERICHIA-COLI;
   RNA-POLYMERASE; SALMONELLA-TYPHIMURIUM; RECOGNITION FACTOR; TRANS
   RECOGNITION; MOUSE VIRULENCE; TAGGING SYSTEM; GENE-PRODUCT
AB The sigma (s) subunit of Escherichia coli RNA polymerase regulates the expression of stationary phase and stress response genes. Control over sigma (s) activity is exercised in part by regulated degradation of sigma (s). In vivo, degradation requires the ClpXP protease together with RssB, a protein homologous to response regulator proteins. Using purified components, we reconstructed the degradation of sigma (s) in vitro and demonstrate a direct role for RssB in delivering sigma (s) to ClpXP. RssB greatly stimulates sigma (s) degradation by ClpXP. Acetyl phosphate, which phosphorylates RssB, is required. RssB participates in multiple rounds of sigma (s) degradation, demonstrating its catalytic role. RssB promotes sigma (s) degradation specifically; it does not affect degradation of other ClpXP substrates or other proteins not normally degraded by ClpXP. sigma (s) and RssB form a stable complex in the presence of acetyl phosphate, and together they form a ternary complex with ClpX that is stabilized by ATP[gamma -S]. Alone, neither sigma (s) nor RssB binds ClpX with high affinity. When ClpP is present, a larger sigma (s)-RssB-ClpXP complex forms. The complex degrades sigma (s) and releases RssB from ClpXP in an ATP-dependent reaction. Our results illuminate an important mechanism for regulated protein turnover in which a unique targeting protein, whose own activity is regulated through specific signaling pathways, catalyzes the delivery of a specific substrate to a specific protease.
C1 NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
   NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Gottesman, S (reprint author), NCI, Mol Biol Lab, NIH, Bldg 37, Bethesda, MD 20892 USA.
NR 44
TC 196
Z9 203
U1 1
U2 7
PU COLD SPRING HARBOR LAB PRESS
PI PLAINVIEW
PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 USA
SN 0890-9369
J9 GENE DEV
JI Genes Dev.
PD MAR 1
PY 2001
VL 15
IS 5
BP 627
EP 637
DI 10.1101/gad.864401
PG 11
WC Cell Biology; Developmental Biology; Genetics & Heredity
SC Cell Biology; Developmental Biology; Genetics & Heredity
GA 410AZ
UT WOS:000167419000012
PM 11238382
ER

PT J
AU Apionishev, S
   Malhotra, D
   Raghavachari, S
   Tanda, S
   Rasooly, RS
AF Apionishev, S
   Malhotra, D
   Raghavachari, S
   Tanda, S
   Rasooly, RS
TI The Drosophila UBC9 homologue lesswright mediates the disjunction of
   homologues in meiosis I
SO GENES TO CELLS
LA English
DT Article
ID KINESIN-LIKE PROTEIN; CHROMOSOME SEGREGATION; GENETIC-ANALYSIS;
   SYNAPTONEMAL COMPLEX; SUMO-1 MODIFICATION; MEIOTIC MUTANT; MELANOGASTER;
   UBIQUITIN; MUTATION; RANGAP1
AB Background: In Saccharomyces cerevisiae and other organisms, the UBC9 (ubiquitin-conjugating 9) protein modifies the function of many different target proteins through covalent attachment of the ubiquitin-like protein SMT-3/SUMO.
   Results: Using a second-site suppression screen of a mutation in the nod locus with a variable meiotic phenotype, we have identified mutations in the Drosophila melanogaster UBC9 homologue, encoded by the gene lesswright (lwr). lwr mutations dominantly suppress the nondisjunction and cytological defects of female meiotic mutations that affect spindle formation. The lwr lethal phenotype is rescued by a Drosophila UBC9/lwr transgene.
   Conclusions: We suggest that LWR mediates the dissociation of heterochromatic regions of homologues at the end of meiotic prophase I. Our model proposes that when there is less LWR protein, homologues remain together longer, allowing for more normal spindle formation in mutant backgrounds and therefore more accurate meiotic chromosome segregation.
C1 St Johns Univ, Dept Biol Sci, Jamaica, NY 11439 USA.
   Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
RP Rasooly, RS (reprint author), NIDA, Div Neurosci & Behav Res, NIH, 6001 Execut Blvd,Room 4260, Bethesda, MD 20892 USA.
OI Rasooly, Rebekah/0000-0002-6357-5528
FU NIGMS NIH HHS [GM50690, GM50978]
NR 40
TC 40
Z9 42
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 1356-9597
J9 GENES CELLS
JI Genes Cells
PD MAR
PY 2001
VL 6
IS 3
BP 215
EP 224
DI 10.1046/j.1365-2443.2001.00413.x
PG 10
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 420KH
UT WOS:000168003800003
PM 11260265
ER

PT J
AU Yang, HP
   Tanikawa, AY
   Van Voorhies, WA
   Silva, JC
   Kondrashov, AS
AF Yang, HP
   Tanikawa, AY
   Van Voorhies, WA
   Silva, JC
   Kondrashov, AS
TI Whole-genome effects of ethyl methanesulfonate-induced mutation on nine
   quantitative traits in outbred Drosophila melanogaster
SO GENETICS
LA English
DT Article
ID SPONTANEOUS DELETERIOUS MUTATION; POLYGENIC MUTATION; RATES;
   POPULATIONS; FITNESS
AB We induced mutations in Drosophila melanogaster males by treating them with 21.2 mM ethyl methanesulfonate (EMS). Nine quantitative traits (developmental time, viability, fecundity, longevity, metabolic rate, motility, body weight, and abdominal and sternopleural bristle numbers) were measured in outbred heterozygous F-3 (viability) or F-2 (all other traits) offspring from the treated males. The mean values of the first four traits, which are all directly related to the life history, were substantially affected by EMS mutagenesis: the developmental time increased while viability, fecundity, and longevity declined. In contrast, the mean values of the other five traits were not significantly affected. Rates of recessive X-linked lethals and of recessive mutations at several loci affecting eye color imply that our EMS treatment was equivalent to similar to 100 generations of spontaneous mutation. If so, our data imply that one generation of spontaneous mutation increases the developmental time by 0.09% at 20 degrees and by 0.04% at 25 degrees, and reduces viability under harsh conditions, fecundity, and longevity by 1.35, 0.21, and 0.08%, respectively. Comparison of flies with none, one, and two grandfathers (or greatgrandfathers, in the case of viability) treated with EMS did not reveal any significant epistasis among the induced mutations.
C1 Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA.
   Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.
   Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
RP Yang, HP (reprint author), Cornell Univ, Dept Ecol & Evolutionary Biol, Corson Hall, Ithaca, NY 14853 USA.
NR 37
TC 31
Z9 31
U1 1
U2 7
PU GENETICS
PI BALTIMORE
PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 USA
SN 0016-6731
J9 GENETICS
JI Genetics
PD MAR
PY 2001
VL 157
IS 3
BP 1257
EP 1265
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 410BK
UT WOS:000167420000028
PM 11238409
ER

PT J
AU Yang, HP
   Tanikawa, AY
   Kondrashov, AS
AF Yang, HP
   Tanikawa, AY
   Kondrashov, AS
TI Molecular nature of 11 spontaneous de novo mutations in Drosophila
   melanogaster
SO GENETICS
LA English
DT Article
ID SPLICING DEFECTS; POINT MUTATIONS; DNA-SEQUENCE; HEMOPHILIA-B; ENZYME
   LOCI; GENE; RATES; EVOLUTION; TRANSCRIPTION; DATABASE
AB To investigate the molecular nature and rate of spontaneous mutation in Drosophila melanogaster, we screened 887,000 individuals for de novo recessive loss-of-function mutations at eight loci that affect eye color. In total, 28 mutants were found in 16 independent events (13 singletons and three clusters). The molecular nature of the 13 events was analyzed. Coding exons of the locus were affected by insertions or deletions >100 nucleotides long (6 events), short frameshift insertions or deletions (4 events), and replacement nucleotide substitutions (1 event). In the case of 2 mutant alleles, coding regions were not affected. Because similar to 70% Of spontaneous de novo loss-of-function mutations in Homo sapiens are due to nucleotide substitutions within coding regions, insertions and deletions appear to play a much larger role in spontaneous mutation in D. melanogaster than in H. sapiens. If so, the per nucleotide mutation rate in D. melanogaster may be lower than in H. sapiens, even if their per locus mutation rates are similar.
C1 Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA.
   Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
RP Yang, HP (reprint author), Cornell Univ, Dept Ecol & Evolutionary Biol, Corson Hall, Ithaca, NY 14853 USA.
NR 52
TC 16
Z9 17
U1 0
U2 2
PU GENETICS
PI BALTIMORE
PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 USA
SN 0016-6731
J9 GENETICS
JI Genetics
PD MAR
PY 2001
VL 157
IS 3
BP 1285
EP 1292
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 410BK
UT WOS:000167420000031
PM 11238412
ER

EF