FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Chung, YW
Lagranha, C
Zmuda-Trzebiatowska, E
Khan, FA
Murphy, E
AF Chung, Youn Wook
Lagranha, Claudia
Zmuda-Trzebiatowska, Emilia
Khan, Faiyaz A.
Murphy, Elizabeth
TI In PDE3B KO mice, White Adipose Tissue (WAT) Exhibits Characteristics of
"Good Fat", i.e., Brown Adipose Tissue (BAT): I. Alterations in
Mitochondrial Biogenesis and Function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Chung, Youn Wook; Lagranha, Claudia; Zmuda-Trzebiatowska, Emilia; Khan, Faiyaz A.; Murphy, Elizabeth] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 856.15
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505057
ER
PT J
AU Clough, RW
Zhang, XM
Cai, HB
Ebersole, J
Yan, C
Struble, RG
Patrylo, PR
Yan, XX
AF Clough, Rich W.
Zhang, Xue-Mei
Cai, Huaibin
Ebersole, Jeremy
Yan, Cai
Struble, Robert G.
Patrylo, Peter R.
Yan, Xiao-Xin
TI Beta secretase localization, amyloid deposition and aberrant synaptic
and neuritic sprouting in transgenic mouse Alzheimer models: a role for
BACE1 in synaptic remodeling and plaque formation?
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Clough, Rich W.; Zhang, Xue-Mei; Ebersole, Jeremy; Patrylo, Peter R.; Yan, Xiao-Xin] SIU Sch Med, Carbondale, IL USA.
[Cai, Huaibin; Yan, Cai] NIA, Neurogenet Lab, Bethesda, MD 20892 USA.
[Struble, Robert G.] SIU Sch Med, Ctr Alzheimers Dis, Springfield, IL USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 834.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504710
ER
PT J
AU Combs, GF
Zeng, HW
Jackson, MI
Johnson, LK
Hoeg, A
Schomburg, L
Davis, CD
Milner, JA
AF Combs, Gerald F.
Zeng, Huawei
Jackson, Matthew I.
Johnson, Luann K.
Hoeg, Antonia
Schomburg, Lutz
Davis, Cindy D.
Milner, John A.
TI Genetic Determinants of Responses to Selenium Supplementation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Combs, Gerald F.; Zeng, Huawei; Jackson, Matthew I.; Johnson, Luann K.] ARS, USDA, Grand Forks, ND USA.
[Hoeg, Antonia; Davis, Cindy D.; Milner, John A.] NCI, Canc Prevent Div, Rockville, MD USA.
[Schomburg, Lutz] Inst Expt Endokrinol, Berlin, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 346.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502782
ER
PT J
AU Cruz, RC
Segura-Perez, S
Vega-Lopez, S
Chhabra, J
Damio, G
Perez-Escamilla, R
AF Cruz, Roberto C.
Segura-Perez, Sofia
Vega-Lopez, Sonia
Chhabra, Jyoti
Damio, Grace
Perez-Escamilla, Rafael
TI Type 2 diabetes peer counseling intervention improves knowledge and
self-management skills
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Cruz, Roberto C.; Perez-Escamilla, Rafael] Univ Connecticut, Connecticut NIH EXPORT Ctr Excellence Eliminating, Storrs, CT USA.
[Segura-Perez, Sofia; Damio, Grace] Hispan Hlth Council, Hartford, CT USA.
[Vega-Lopez, Sonia] Arizona State Univ, Mesa, AZ USA.
[Chhabra, Jyoti] Hartford Hosp, Hartford, CT 06115 USA.
NR 0
TC 1
Z9 1
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 736.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502418
ER
PT J
AU Davies, DR
AF Davies, David R.
TI Fifty years of Protein Structure: From Myoglobin to the Innate Immune
System
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Davies, David R.] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 24.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501676
ER
PT J
AU De Donatis, GM
Piszczek, G
Maurizi, MR
AF De Donatis, Gian Marco
Piszczek, Grzegorz
Maurizi, Michael R.
TI Peptide binding affects the conformation and ATPase activity of the
Bacterial AAA+ domain 2 of ClpA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [De Donatis, Gian Marco; Piszczek, Grzegorz; Maurizi, Michael R.] NCI, NIH, Bethesda, MD 20892 USA.
[Piszczek, Grzegorz] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 673.13
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506438
ER
PT J
AU Deen, PMT
Tamma, G
Stoffels, M
Hoffert, JD
Konings, IBM
Knepper, MA
AF Deen, Peter M. T.
Tamma, Grazia
Stoffels, Monique
Hoffert, Jason D.
Konings, Irene B. M.
Knepper, Mark A.
TI Changing S261, including constitutive phosphorylation, enhances AQP2
ubiquitination and internalization
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Deen, Peter M. T.; Stoffels, Monique; Konings, Irene B. M.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Tamma, Grazia] Univ Bari, I-70125 Bari, Italy.
[Hoffert, Jason D.; Knepper, Mark A.] NHLBI, Bethesda, MD 20892 USA.
RI Deen, P.M.T./H-8023-2014; Tamma, Grazia/F-8823-2016
OI Deen, P.M.T./0000-0002-7868-4655;
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 998.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506354
ER
PT J
AU Dmitrieva, NI
Burg, MB
AF Dmitrieva, Natalia I.
Burg, Maurice B.
TI Increased nuclease activity in response to high NaCl
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Dmitrieva, Natalia I.; Burg, Maurice B.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1001.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500755
ER
PT J
AU Dodd, KW
Bailey, R
Wilger, J
Sempos, C
Dwyer, J
Radimer, K
McDowell, M
Johnson, C
Picciano, MF
AF Dodd, Kevin W.
Bailey, Regan
Wilger, Jaime
Sempos, Chris
Dwyer, Johanna
Radimer, Kathy
McDowell, Margaret
Johnson, Cliff
Picciano, Mary Frances
TI Estimating distributions of usual total nutrient intake: A comparison of
available methods
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Dodd, Kevin W.] NCI, Bethesda, MD 20892 USA.
[Bailey, Regan; Sempos, Chris; Dwyer, Johanna; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
[Wilger, Jaime; Radimer, Kathy; McDowell, Margaret; Johnson, Cliff] Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 341.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505372
ER
PT J
AU Eisner, CB
Muller, F
Huang, YN
Briggs, J
Schnermann, J
AF Eisner, Christoph Benedikt
Muller, Florian
Huang, Yuning
Briggs, Josephine
Schnermann, Jurgen
TI Reduced Wheel Running Activity in beta 1/beta 2 Adrenergic Receptor
Knockout Mice is not Caused by Anxiety
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Eisner, Christoph Benedikt; Huang, Yuning; Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD USA.
[Muller, Florian] NCI, NIH, Bethesda, MD 20892 USA.
[Briggs, Josephine] NIH, NCCAM, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 955.33
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505432
ER
PT J
AU Eisner, CB
Qin, Y
Thiel, M
Briggs, J
Schnermann, J
AF Eisner, Christoph Benedikt
Qin, Yan
Thiel, Manfred
Briggs, Josephine
Schnermann, Jurgen
TI 5 '-AMP and its Role in Fasting-Induced Torpor and Hypothermia in
Ecto-nucleotidase Knockout (CD73-/-) Mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Eisner, Christoph Benedikt; Qin, Yan; Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD USA.
[Briggs, Josephine] NCCAM, NIH, Bethesda, MD USA.
[Thiel, Manfred] LMU, Munich, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1034.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505323
ER
PT J
AU Eisner, CB
Faulhaber-Walter, R
Wang, YH
Levine, M
Briggs, J
Schnermann, J
AF Eisner, Christoph Benedikt
Faulhaber-Walter, Robert
Wang, Yaohui
Levine, Mark
Briggs, Josephine
Schnermann, Jurgen
TI Gender Differences of Creatinine Excretion in Mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Eisner, Christoph Benedikt; Wang, Yaohui; Levine, Mark; Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD USA.
[Briggs, Josephine] NIH, NCCAM, Bethesda, MD 20892 USA.
[Faulhaber-Walter, Robert] Hannover Med Sch, D-30623 Hannover, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 804.18
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505179
ER
PT J
AU Eisner, CB
Espey, M
Ow, H
Wang, KW
Wiesner, U
Schnermann, J
AF Eisner, Christoph Benedikt
Espey, Mike
Ow, Hooisweng
Wang, Kenneth W.
Wiesner, Ulrich
Schnermann, Jurgen
TI Measurement of Plasma Volume using Nanoparticles in Mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Eisner, Christoph Benedikt; Espey, Mike; Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD USA.
[Ow, Hooisweng; Wang, Kenneth W.] Hybrid Sil Technol Inc, Ithaca, NY USA.
[Wiesner, Ulrich] Cornell Univ, Ithaca, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 804.19
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504657
ER
PT J
AU Feng, H
Leung, PK
Hu, L
Krsmanovic, LZ
Catt, KJ
AF Feng, Hao
Leung, Po Ki
Hu, Lian
Krsmanovic, Lazar Z.
Catt, Kevin J.
TI Roles of Tyrosine(322) and Tyrosine(324) in GnRH Receptor Function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Feng, Hao; Leung, Po Ki; Hu, Lian; Krsmanovic, Lazar Z.; Catt, Kevin J.] NICHD, ERRB, PDEGEN, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 880.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500763
ER
PT J
AU Fitzgerald, K
Zhang, ZY
Bagshaw, D
Colburn, N
Kris-Etherton, P
Lanza, E
Hartman, T
AF Fitzgerald, Kathryn
Zhang, Zhiying
Bagshaw, Deborah
Colburn, Nancy
Kris-Etherton, Penny
Lanza, Elaine
Hartman, Terry
TI The Legume Inflammation Feeding Experiment (LIFE): Weight Loss Effects
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Fitzgerald, Kathryn; Zhang, Zhiying; Bagshaw, Deborah; Kris-Etherton, Penny; Hartman, Terry] Penn State Univ, University Pk, PA 16802 USA.
[Colburn, Nancy] NCI, Frederick, MD 21701 USA.
[Lanza, Elaine] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 898.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504023
ER
PT J
AU Franco, R
Cidlowski, JA
AF Franco, Rodrigo
Cidlowski, John A.
TI Protein glutathionylation regulates FasL-induced apoptosis.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Franco, Rodrigo; Cidlowski, John A.] NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 526.17
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504651
ER
PT J
AU Free, RB
Namkung, Y
Hazelwood, LA
Cabrera, DM
Sibley, DR
AF Free, R. Benjamin
Namkung, Yoon
Hazelwood, Lisa A.
Cabrera, David M.
Sibley, David R.
TI Characterization of sorting nexin-25, a D-1 and D-2 dopamine receptor
interacting protein that regulates receptor expression and trafficking
in HEK293 cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Free, R. Benjamin; Namkung, Yoon; Hazelwood, Lisa A.; Cabrera, David M.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, NIH, Rockville, MD USA.
RI Cabrera, David/I-1013-2014
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 942.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505101
ER
PT J
AU Fuchs, BA
Knorr, D
AF Fuchs, Bruce A.
Knorr, Debra
TI Science in the Cinema Summer Film Festival
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Fuchs, Bruce A.; Knorr, Debra] NIH, Off Sci Educ, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 68.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500329
ER
PT J
AU Fuchs, BA
Knorr, D
AF Fuchs, Bruce A.
Knorr, Debbie
TI Science in the Cinema
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Fuchs, Bruce A.; Knorr, Debbie] NIH, Off Sci Educ, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500299
ER
PT J
AU Galbraith, VK
Giedt, RJ
Panduri, V
Van Houten, B
Alevriadou, BR
AF Galbraith, Valerie K.
Giedt, Randy J.
Panduri, Vijji
Van Houten, Bennett
Alevriadou, B. Rita
TI Mitochondrial DNA damage in vascular endothelial cells exposed to shear
stress
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Galbraith, Valerie K.; Giedt, Randy J.; Alevriadou, B. Rita] Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
[Galbraith, Valerie K.] Ohio State Univ, IBGP, Columbus, OH 43210 USA.
[Panduri, Vijji] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Van Houten, Bennett] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 638.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501730
ER
PT J
AU Gallazzini, M
Villers, CL
Burg, MB
Ferraris, JD
AF Gallazzini, Morgan
Villers, Courtney L.
Burg, Maurice B.
Ferraris, Joan D.
TI High NaCl activates c-Abl kinase, phosphorylating TonEBP/OREBP on Y143,
which contributes to its increased nuclear localization
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Gallazzini, Morgan; Villers, Courtney L.; Burg, Maurice B.; Ferraris, Joan D.] NHLBI, NIH, LKEM, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1001.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501244
ER
PT J
AU Pardo, VG
Martin, D
Gutkind, SJ
Facchinetti, MM
Verstuyf, A
Boland, R
de Boland, AR
AF Gonzalez Pardo, Veronica
Martin, Daniel
Gutkind, Silvio J.
Facchinetti, Maria M.
Verstuyf, AnnMike
Boland, Ricardo
Russo de Boland, Ana
TI 1 alpha,25(OH) (2)-vitamin D-3 and its TX527 analog inhibit the growth
of endothelial cells transformed by Kaposi sarcoma-associated herpes
virus G protein couple receptor in vitro and in vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Gonzalez Pardo, Veronica; Boland, Ricardo; Russo de Boland, Ana] Univ Nacl Sur, Dept Biol Bioquim & Farm, RA-8000 Bahia Blanca, Buenos Aires, Argentina.
[Facchinetti, Maria M.] INIBIBB CONICET, Bahia Blanca, Buenos Aires, Argentina.
[Martin, Daniel; Gutkind, Silvio J.] NIH, Bethesda, MD 20892 USA.
[Verstuyf, AnnMike] Lab Expt Geneeskunde Endocrinol, Louvain, Belgium.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 491.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500002
ER
PT J
AU Hager, GL
Sabo, P
Thurman, R
Stamatoyannopoulos, JA
Sung, MH
Biddie, SC
John, S
AF Hager, Gordon Lee
Sabo, Pete
Thurman, Robert
Stamatoyannopoulos, John A.
Sung, Myong-Hee
Biddie, Simon C.
John, Sam
TI Interaction of the Glucocorticoid Receptor with the Chromatin Landscape
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hager, Gordon Lee; Sung, Myong-Hee; Biddie, Simon C.; John, Sam] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA.
[Sabo, Pete; Thurman, Robert; Stamatoyannopoulos, John A.] Dept Genome Sci, Seattle, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 487.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504389
ER
PT J
AU Hall, KD
Jordan, PN
AF Hall, Kevin D.
Jordan, Peter N.
TI Calculating the permanent lifestyle changes required for weight-loss
maintenance
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hall, Kevin D.; Jordan, Peter N.] NIDDK, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 212.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504043
ER
PT J
AU Hall, T
Miller, M
Wang, YM
Zhu, D
Opperman, L
Stumpf, C
Wickens, M
AF Hall, Traci
Miller, Matthew
Wang, Yeming
Zhu, Deyu
Opperman, Laura
Stumpf, Craig
Wickens, Marvin
TI Probing RNA sequence specificity and function of PUF proteins
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hall, Traci; Miller, Matthew; Wang, Yeming; Zhu, Deyu] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Opperman, Laura; Stumpf, Craig; Wickens, Marvin] Univ Wisconsin, Dept Biochem, Madison, WI 53705 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 326.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500747
ER
PT J
AU Hazelwood, LA
Free, RB
Cabrera, DM
Sibley, DR
AF Hazelwood, Lisa A.
Free, R. Benjamin
Cabrera, David M.
Sibley, David R.
TI Alterations in D2 dopamine receptor internalization in the presence of
the Na+/K+-ATPase
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hazelwood, Lisa A.; Free, R. Benjamin; Cabrera, David M.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, NIH, Rockville, MD USA.
RI Cabrera, David/I-1013-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 938.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505412
ER
PT J
AU Hinton, DR
Kase, S
He, SK
Sonoda, S
Wawrousek, E
Kannan, R
AF Hinton, David Ralph
Kase, Satoru
He, Shikun
Sonoda, Shozo
Wawrousek, Eric
Kannan, Ram
TI AlphaB crystallin regulation of ocular angiogenesis by modulation of
vascular endothelial growth factor protein expression
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hinton, David Ralph; Kase, Satoru; He, Shikun; Sonoda, Shozo; Kannan, Ram] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
[Wawrousek, Eric] NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 116.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506529
ER
PT J
AU Hinton, DR
Kase, S
He, SK
Sonoda, S
Wawrousek, E
Kannan, R
AF Hinton, David Ralph
Kase, Satoru
He, Shikun
Sonoda, Shozo
Wawrousek, Eric
Kannan, Ram
TI AlphaB crystallin regulation of ocular angiogenesis by modulation of
vascular endothelial growth factor
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hinton, David Ralph; Kase, Satoru; He, Shikun; Sonoda, Shozo; Kannan, Ram] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
[Wawrousek, Eric] NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506458
ER
PT J
AU Hiranita, T
Newman, AH
Katz, JL
AF Hiranita, Takato
Newman, Amy H.
Katz, Jonathan L.
TI Attenuation of Cocaine Self-Administration by Dual Inhibition of the
Dopamine Transporter and Sigma Receptors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hiranita, Takato; Newman, Amy H.; Katz, Jonathan L.] NIDA, Medicat Discovery Res Branch, Baltimore, MD USA.
RI Hiranita, Takato/G-6567-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 588.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505833
ER
PT J
AU Hu, KN
Yau, WM
Tycko, R
AF Hu, Kan-Nian
Yau, Wai-Ming
Tycko, Robert
TI Rapid Freezing Quench of Transient Conformations of Folding Proteins for
Solid State NMR Studies
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hu, Kan-Nian; Yau, Wai-Ming; Tycko, Robert] NIDDK, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 850.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500322
ER
PT J
AU Huang, KP
Huang, FL
AF Huang, Kuo-Ping
Huang, Freesia L.
TI Ca2+-sensitive redistribution of calmodulin and neurogranin in CA1
pyramidal neurons of mouse hippocampus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Huang, Kuo-Ping; Huang, Freesia L.] NICHD, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 885.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505579
ER
PT J
AU Hurley, JH
AF Hurley, James H.
TI The ESCRT Complexes: from Lysosome Biogenesis to Viral Budding
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hurley, James H.] NIDDK, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 433.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501009
ER
PT J
AU Im, YJ
Hurley, JH
AF Im, Young Jun
Hurley, James H.
TI Integrated structural and functional model of the human ESCRT-II complex
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Im, Young Jun; Hurley, James H.] NIDDK, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 683.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501019
ER
PT J
AU Jackson, MI
Johnson, LK
Hoeg, A
Hoefig, C
Davis, CD
Milner, JA
Schomburg, L
Combs, GF
AF Jackson, Matthew I.
Johnson, Luann K.
Hoeg, Antonia
Hoefig, Carolin
Davis, Cindy D.
Milner, John A.
Schomburg, Lutz
Combs, Gerald F.
TI Components of Plasma Selenium in Healthy Americans
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Jackson, Matthew I.; Combs, Gerald F.] ARS, USDA, Grand Forks, ND USA.
[Johnson, Luann K.] Univ N Dakota, Grand Forks, ND 58201 USA.
[Hoeg, Antonia; Hoefig, Carolin; Davis, Cindy D.; Milner, John A.] NCI, Rockville, MD USA.
[Schomburg, Lutz] Inst Fuer Expt Endokrinol, Berlin, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 346.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504429
ER
PT J
AU Jayachandran, M
Preston, CC
Hunter, LW
Jahangir, A
Owen, WG
Korach, KS
Miller, VM
AF Jayachandran, Muthuvel
Preston, Claudia C.
Hunter, Larry W.
Jahangir, Arshad
Owen, Whyte G.
Korach, Kenneth S.
Miller, Virginia M.
TI Contribution of Estrogen receptor beta (ER beta) on platelet
mitochondrial function and microparticle production in aged female mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Jayachandran, Muthuvel; Preston, Claudia C.; Hunter, Larry W.; Jahangir, Arshad; Owen, Whyte G.; Miller, Virginia M.] Mayo Clin, Coll Med, Rochester, MN USA.
[Korach, Kenneth S.] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 988.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500829
ER
PT J
AU Jeang, KT
AF Jeang, Kuan-Teh
TI Insights into novel host factors required for HIV-1 replication in human
cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Jeang, Kuan-Teh] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 96.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500497
ER
PT J
AU Johnson, CL
Hughes, J
Radimer, K
Wilger, JJ
Dwyer, J
Picciano, MF
Bailey, RL
Sempos, C
AF Johnson, Clifford L.
Hughes, Jeffrey
Radimer, Kathy
Wilger, Jaime J.
Dwyer, Johanna
Picciano, Mary Frances
Bailey, Regan L.
Sempos, Christopher
TI Methodologic differences in dietary supplements data collection and
processing between the Third National Health and Nutrition Examination
Survey (NHANES III) and the continuous NHANES (1999-2006)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Johnson, Clifford L.; Hughes, Jeffrey; Radimer, Kathy; Wilger, Jaime J.] CDC, DHANES, NCHS, Hyattsville, MD USA.
[Dwyer, Johanna; Picciano, Mary Frances; Bailey, Regan L.; Sempos, Christopher] NIH, ODS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 341.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506036
ER
PT J
AU Kang, JH
Dong, J
Tsai-Morris, CH
Dufau, ML
AF Kang, Jung-Hoon
Dong, J.
Tsai-Morris, C. H.
Dufau, M. L.
TI Interaction Domains of Components of the ER alpha/Sp1 and C/EBP beta
Complex Essential for Prolactin Receptor Transcription.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kang, Jung-Hoon; Dong, J.; Tsai-Morris, C. H.; Dufau, M. L.] NICHD, Sect Mol Endocrinol, ERRB, PDEGEN,NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 494.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506745
ER
PT J
AU Kang, JH
Dong, J
Tsai-Morris, CH
Dufau, ML
AF Kang, Jung-Hoon
Dong, J.
Tsai-Morris, C. H.
Dufau, M. L.
TI Interaction Domains of Components of the ER alpha/Sp1 and C/EBP beta
Complex Essential for Prolactin Receptor Transcription.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kang, Jung-Hoon; Dong, J.; Tsai-Morris, C. H.; Dufau, M. L.] NICHD, Sect Mol Endocrinol, ERRB, PDEGEN,NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 494.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506876
ER
PT J
AU Kasaikina, MV
Fomenko, DE
Jones, CJ
Reddy, J
Hatfield, DL
Gladyshev, VN
AF Kasaikina, Marina V.
Fomenko, Dmitry E.
Jones, Clinton J.
Reddy, Jay
Hatfield, Dolph L.
Gladyshev, Vadim N.
TI Involvement of Sep15 family members in immune response
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kasaikina, Marina V.; Fomenko, Dmitry E.; Jones, Clinton J.; Reddy, Jay; Gladyshev, Vadim N.] Univ Nebraska Lincoln, Lincoln, NE USA.
[Hatfield, Dolph L.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 346.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506461
ER
PT J
AU Kato, J
Zhu, JF
Kasamatsu, A
Liu, CY
Hoffmann, V
Lizak, MJ
Moss, J
AF Kato, Jiro
Zhu, Jainfeng
Kasamatsu, Atsushi
Liu, Chengyu
Hoffmann, Victoria
Lizak, Martin J.
Moss, Joel
TI Effects of ADP-ribosylarginine Hydrolase (ARH1) on Cell Proliferation
and Tumorigenesis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kato, Jiro; Zhu, Jainfeng; Kasamatsu, Atsushi; Moss, Joel] NHLBI, TMB, NIH, Bethesda, MD 20892 USA.
[Liu, Chengyu] NHLBI, Transgen Mouse Core Facil, NIH, Bethesda, MD 20892 USA.
[Hoffmann, Victoria] NIH, Diagnost & Reaserch Serv Branch, Div Vet, Bethesda, MD 20892 USA.
[Lizak, Martin J.] NIH, Mouse Imaging Facil, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 859.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504841
ER
PT J
AU Khan, FA
Zmuda-Trzebiatowska, E
Degerman, E
Manganiello, V
AF Khan, Faiyaz Ahmad
Zmuda-Trzebiatowska, Emilia
Degerman, Eva
Manganiello, Vincent
TI The Roles of Serine/Threonine Protein Phosphatases in Regulation of
PDE3B Signaling in 3T3-L1 Adipocytes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Khan, Faiyaz Ahmad; Zmuda-Trzebiatowska, Emilia; Manganiello, Vincent] NHLBI, TMB, NIH, Bethesda, MD 20892 USA.
[Degerman, Eva] Lund Univ, Lund, Sweden.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 891.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505016
ER
PT J
AU Khan, FA
Tang, Y
Chung, YW
Zmuda-Trzebiatowska, E
Hockman, S
Gavrilova, O
Berger, K
Degerman, E
Manganiello, V
AF Khan, Faiyaz Ahmad
Tang, Yan
Chung, Youn Wook
Zmuda-Trzebiatowska, Emilia
Hockman, Steve
Gavrilova, Oksana
Berger, Karin
Degerman, Eva
Manganiello, Vincent
TI In PDE3B KO mice, White Adipose Tissue (WAT) Exhibits Characteristics of
"Good Fat," i.e., Brown Adipose Tissue (BAT): II. Alterations in
Angiogenesis and cAMP-and AMP Kinase-signaling
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Khan, Faiyaz Ahmad; Tang, Yan; Chung, Youn Wook; Zmuda-Trzebiatowska, Emilia; Hockman, Steve; Manganiello, Vincent] NHLBI, TMB, NIH, Bethesda, MD 20892 USA.
[Gavrilova, Oksana] NIDDK, NIH, Bethesda, MD USA.
[Berger, Karin; Degerman, Eva] Lund Univ, Lund, Sweden.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 856.13
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504819
ER
PT J
AU Khan, FA
Krall, J
Vandeput, F
Shen, WX
Manganiello, V
Movsesian, M
AF Khan, Faiyaz Ahmad
Krall, Judith
Vandeput, Fabrice
Shen, Weixing
Manganiello, Vincent
Movsesian, Matthew
TI Subcellular Localization of Human Myocardial PDE3 Isoforms and
Components of cAMP Signaling Pathways
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Khan, Faiyaz Ahmad; Shen, Weixing; Manganiello, Vincent] NHLBI, TMB, NIH, Bethesda, MD 20892 USA.
[Krall, Judith; Vandeput, Fabrice; Movsesian, Matthew] Univ Utah, Salt Lake City, UT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 891.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504487
ER
PT J
AU Khositseth, S
Yu, MJ
Pisitkun, T
Tchapyjnikov, D
Knepper, MA
AF Khositseth, Sookkasem
Yu, M-J
Pisitkun, T.
Tchapyjnikov, D.
Knepper, M. A.
TI Quantitative proteomic analysis of long-term vasopressin actions in
mpkCCD cells using SILAC and MRM
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Khositseth, Sookkasem; Yu, M-J; Pisitkun, T.; Tchapyjnikov, D.; Knepper, M. A.] NHLBI, Bethesda, MD 20892 USA.
[Khositseth, Sookkasem] Thammasat Univ, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 970.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502850
ER
PT J
AU Koek, W
Campos, PS
France, CP
Cheng, K
Rice, KC
AF Koek, Wouter
Campos, Peter S.
France, Charles P.
Cheng, Kejun
Rice, Kenner C.
TI GHB- and baclofen-induced hypothermia in mice: interactions with the
GABA-B receptor positive modulator CGP7930, the GABA-B receptor
antagonist CGP35348, and the NOS inhibitor L-NAME
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Koek, Wouter; Campos, Peter S.; France, Charles P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Cheng, Kejun; Rice, Kenner C.] NIDA, Chem Biol Res Branch, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 938.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500806
ER
PT J
AU Kopajtic, T
Cao, JJ
Hiranita, T
Tanda, G
Newman, AH
Katz, JL
AF Kopajtic, Theresa
Cao, Jianjing
Hiranita, Takato
Tanda, Gianluigi
Newman, Amy H.
Katz, Jonathan L.
TI Development of Drugs with Dual Dopamine Transporter and Sigma(1)
Receptor Activity
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kopajtic, Theresa; Cao, Jianjing; Hiranita, Takato; Tanda, Gianluigi; Newman, Amy H.; Katz, Jonathan L.] NIDA, Medicat Discovery Res Branch, Baltimore, MD USA.
RI Tanda, Gianluigi/B-3318-2009; Hiranita, Takato/G-6567-2011
OI Tanda, Gianluigi/0000-0001-9526-9878;
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 745.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505831
ER
PT J
AU Kopajtic, T
Cao, JG
Takato, H
Gianluigi, T
Newman, AH
Katz, JL
AF Kopajtic, Theresa
Cao, Jianging
Takato, Hiranita
Gianluigi, Tanda
Newman, Amy H.
Katz, Jonathan L.
TI Development of dual inhibitors of the dopamine transporter and sigma(1)
receptors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kopajtic, Theresa; Cao, Jianging; Takato, Hiranita; Gianluigi, Tanda; Newman, Amy H.; Katz, Jonathan L.] NIDA, Medicat Discovery Res Branch, Intramural Res Program, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505274
ER
PT J
AU Krebs, NF
Mazariegos, M
Chomba, E
Tshefu, A
Pasha, O
Goco, N
Das, A
Kindem, M
Wright, LL
Hambidge, M
AF Krebs, Nancy F.
Mazariegos, Manolo
Chomba, Elwyn
Tshefu, Antoinette
Pasha, Omrana
Goco, Norman
Das, Abhik
Kindem, Mark
Wright, Linda L.
Hambidge, Michael
TI Stunting and wasting rates in diverse settings in developing countries
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Krebs, Nancy F.; Hambidge, Michael] Univ CO, Aurora, CO USA.
[Mazariegos, Manolo] CESSIAM, Guate City, Guatemala.
[Chomba, Elwyn] Univ Teaching Hosp, Lusaka, Zambia.
[Tshefu, Antoinette] Kinshasa Sch Pub Hlth, Kinshasa, Zaire.
[Pasha, Omrana] Aga Khan Univ, Karachi, Pakistan.
[Goco, Norman; Das, Abhik; Kindem, Mark] RTI Int Inc, Res Triangle Pk, NC USA.
[Wright, Linda L.] NICHD, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 916.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505149
ER
PT J
AU Lagranha, CJ
Steenbergen, C
Murphy, E
AF Lagranha, Claudia Jacques
Steenbergen, Charles
Murphy, Elizabeth
TI Male-female differences in post translational modifications of
mitochondrial proteins
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lagranha, Claudia Jacques; Murphy, Elizabeth] NHLBI, Translat Med Branch, NIH, Bethesda, MD 20892 USA.
[Steenbergen, Charles] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA.
RI Liu, Wenhua/B-8044-2010
OI Liu, Wenhua/0000-0002-1199-435X
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 508.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501084
ER
PT J
AU Lee, HH
Elia, N
Ghirlando, R
Lippincott-Schwartz, J
Hurley, JH
AF Lee, Hyung Ho
Elia, Natalie
Ghirlando, Rodolfo
Lippincott-Schwartz, Jennifer
Hurley, James H.
TI Midbody targeting of the ESCRT machinery by a noncanonical coiled coil
in CEP55
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lee, Hyung Ho; Ghirlando, Rodolfo; Hurley, James H.] NIDDK, NIH, Bethesda, MD USA.
[Elia, Natalie; Lippincott-Schwartz, Jennifer] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 864.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500835
ER
PT J
AU Li, JX
Rice, KC
Koek, W
France, CP
AF Li, Jun-Xu
Rice, Kenner C.
Koek, Wouter
France, Charles P.
TI Discriminative stimulus effects of DOM in rhesus monkeys: interactions
between 5-HT1A and 5-HT2A receptor agonists
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Li, Jun-Xu; Koek, Wouter; France, Charles P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
[Koek, Wouter; France, Charles P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
[Rice, Kenner C.] NIDA, Chem Biol Res Branch, Baltimore, MD USA.
[Rice, Kenner C.] NIAAA, NIH, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 743.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504178
ER
PT J
AU Lin, R
Cao, HP
AF Lin, Rui
Cao, Heping
TI Evaluation of His-tag and immunoprecipitation procedures for recombinant
protein purification
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lin, Rui; Cao, Heping] NIEHS, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Cao, Heping] USDA ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, Beltsville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 518.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502840
ER
PT J
AU Lin, YH
Song, BJ
Llanos, AR
Lefkowitz, W
Uauy, R
Salem, N
AF Lin, Yu Hong
Song, Byoung-Joon
Llanos, Adolfo R.
Lefkowitz, William
Uauy, Ricardo
Salem, Norman, Jr.
TI Characterization of essential fatty acid metabolism using the stable
isotope tracer technique and gas chromatography/mass spectrometric assay
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lin, Yu Hong; Song, Byoung-Joon; Lefkowitz, William; Salem, Norman, Jr.] NIH, Lab Membrane Biochem & Biophys, Bethesda, MD 20892 USA.
[Llanos, Adolfo R.] Arnot Ogden Med Ctr, New York, NY USA.
[Uauy, Ricardo] London Sch Hyg & Trop Med, London WC1, England.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 506.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501121
ER
PT J
AU Lobanov, AV
Turanov, AA
Klobutcher, LA
Hatfield, DL
Gladyshev, VN
AF Lobanov, Alexey V.
Turanov, Anton A.
Klobutcher, Lawrence A.
Hatfield, Dolph L.
Gladyshev, Vadim N.
TI The Euplotes crassus selenoproteome
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lobanov, Alexey V.; Turanov, Anton A.; Gladyshev, Vadim N.] Univ Nebraska Lincoln, Lincoln, NE USA.
[Klobutcher, Lawrence A.] Univ Connecticut, Ctr Hlth, Farmington, CT USA.
[Hatfield, Dolph L.] NCI, Mol Biol Selenium Sect, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 338.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506423
ER
PT J
AU Mandin, P
Gottesman, S
AF Mandin, Pierre
Gottesman, Susan
TI A reversed approach for finding small RNAs regulating genes of interest
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Mandin, Pierre; Gottesman, Susan] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 846.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504198
ER
PT J
AU Marzec, JM
Hertzberg, A
Yoon, HK
Kleeberger, S
AF Marzec, Jacqui M.
Hertzberg, Andrew
Yoon, Hyoung-Kyu
Kleeberger, Steve
TI Association of NRF2 and NQO1 Polymorphisms and Susceptibility to
Emphysema
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Marzec, Jacqui M.; Kleeberger, Steve] NIEHS, Lab Resp Biol, Res Triangle Pk, NC 27709 USA.
[Hertzberg, Andrew] Chapel Hill High Sch, Chapel Hill, NC USA.
[Yoon, Hyoung-Kyu] Catholic Univ Korea, Dept Internal Med, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 795.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501815
ER
PT J
AU McCoy, LF
Jorgensen, WI
Chew, EY
Kim, J
Wong, WT
Schleicher, RL
AF McCoy, Leslie F.
Jorgensen, Wanda I.
Chew, Emily Y.
Kim, Jonghyeon
Wong, Wai T.
Schleicher, Rosemary L.
TI Biological variation in the plasma concentrations of polyunsaturated
long chain fatty acids (PUFA) in older adults
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [McCoy, Leslie F.] AAS, Atlanta, GA USA.
[Jorgensen, Wanda I.; Schleicher, Rosemary L.] Ctr Dis Control & Prevent, NCEH, DLS, NBB, Atlanta, GA USA.
[Chew, Emily Y.; Wong, Wai T.] NEI, DBE, CTB, NIH, Bethesda, MD 20892 USA.
[Kim, Jonghyeon] EMMES Corp, Rockville, MD USA.
RI Wong, Wai/B-6118-2017
OI Wong, Wai/0000-0003-0681-4016
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 334.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506585
ER
PT J
AU Mears, JA
Ray, P
Fang, S
Lackner, L
Nunnari, J
Hinshaw, JE
AF Mears, Jason A.
Ray, Pampa
Fang, Shunming
Lackner, Laura
Nunnari, Jodi
Hinshaw, Jenny E.
TI The Role of Dynamin Family Members in Membrane Fission
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Mears, Jason A.; Ray, Pampa; Fang, Shunming; Hinshaw, Jenny E.] NIH, LCBB, Bethesda, MD 20892 USA.
[Lackner, Laura; Nunnari, Jodi] Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 82.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500569
ER
PT J
AU Moaddel, R
Sanghvi, M
Marszall, M
Kole, S
Bernier, M
Wainer, IW
AF Moaddel, Ruin
Sanghvi, Mitesh
Marszall, Michal
Kole, Sutapa
Bernier, Michel
Wainer, Irving W.
TI A probe for chaperone/multiprotein complexes and inhibitors in
biological matrices
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Moaddel, Ruin; Sanghvi, Mitesh; Marszall, Michal; Kole, Sutapa; Bernier, Michel; Wainer, Irving W.] NIA, GRC, NIH, Baltimore, MD 21224 USA.
RI Marszall, Michal/G-8936-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 756.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501086
ER
PT J
AU Moeller, HB
MacAulay, N
Knepper, MA
Fenton, RA
AF Moeller, Hanne B.
MacAulay, Nanna
Knepper, Mark A.
Fenton, Robert A.
TI Functional role of multiple phosphorylation sites in the
carboxyl-terminal tail of the water channel Aquaporin-2
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Moeller, Hanne B.; Fenton, Robert A.] Univ Aarhus, Water & Salt Res Ctr, Aarhus, Denmark.
[MacAulay, Nanna] Univ Copenhagen, Panum Inst, Inst Cellular & Mol Med, DK-2200 Copenhagen, Denmark.
[Knepper, Mark A.] NHLBI, Kidney & Electrolyte Metab Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 998.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500807
ER
PT J
AU Moon, K
Gottesman, S
AF Moon, Kyung
Gottesman, Susan
TI A Bacterial Regulatory Small RNA Perturbing LPS Modification
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Moon, Kyung; Gottesman, Susan] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 846.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504282
ER
PT J
AU Myung, K
Banerjee, S
Yang, KL
Sikdar, N
Lee, KY
Cohn, M
Wincovitch, S
Pak, E
Nakanishi, K
Jasin, M
Dutra, A
D'Andrea, A
AF Myung, Kyungjae
Banerjee, Soma
Yang, Kailin
Sikdar, Nilabja
Lee, Kyoo-young
Cohn, Martin
Wincovitch, Stephen
Pak, Evgenia
Nakanishi, Koji
Jasin, Maria
Dutra, Amalia
D'Andrea, Alan
TI Human ELG1 regulates the level of monoubiquitinated PCNA through
interactions with PCNA, USP1, and polymerase eta
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Myung, Kyungjae; Banerjee, Soma; Sikdar, Nilabja; Lee, Kyoo-young; Wincovitch, Stephen; Pak, Evgenia; Dutra, Amalia] NHGRI, NIH, Bethesda, MD 20892 USA.
[Yang, Kailin; Cohn, Martin; D'Andrea, Alan] Hovard Med Sch, Boston, MA USA.
[Nakanishi, Koji; Jasin, Maria] Mem Sloan Kettering Canc Ctr, Dev Biol Program, New York, NY 10021 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 836.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500485
ER
PT J
AU Nayeem, MA
Boegehold, MA
Ponnoth, DS
Roush, KP
Zeldin, DC
Falck, JR
Mustafa, SJ
AF Nayeem, Mohammed A.
Boegehold, Matthew A.
Ponnoth, Dovenia S.
Roush, Kevin P.
Zeldin, Darryl C.
Falck, John R.
Mustafa, S. Jamal
TI Enhanced vascular relaxation through epoxygenase depends on
ATP-sensitive K plus channels via adenosine A2A receptor: Role of high
salt diet
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Nayeem, Mohammed A.; Boegehold, Matthew A.; Ponnoth, Dovenia S.; Roush, Kevin P.; Mustafa, S. Jamal] W Virginia Univ, CIRCS, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
[Zeldin, Darryl C.] NIEHS, Intramural Res Program, NIH, Res Triangle Pk, NC 27709 USA.
[Falck, John R.] UT SW Med Ctr, Dallas, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1019.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500441
ER
PT J
AU Negus, SS
Banks, ML
Schrode, K
Morrissey, E
Rice, KC
AF Negus, S. Stevens
Banks, Matthew L.
Schrode, Katrina
Morrissey, Ember
Rice, Kenner C.
TI Selective but Slight Enhancement of Delta Agonist-Induced
Antinociception by Repeated Morphine in Rhesus Monkeys
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Negus, S. Stevens; Banks, Matthew L.; Schrode, Katrina; Morrissey, Ember] Virginia Commonwealth Univ, Richmond, VA USA.
[Rice, Kenner C.] NIDA, Chem Biol Res Branch, NIAAA, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 742.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504273
ER
PT J
AU Oubrahim, H
Chock, PB
AF Oubrahim, Hammou
Chock, P. Boon
TI Pasteurella multocida toxin-induced Gaq-dependent mTOR-mediated
ribosomal S6 protein phosphorylation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Oubrahim, Hammou; Chock, P. Boon] NHLBI, Biochem Lab, BBC, DIR,NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 704.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502429
ER
PT J
AU Pacher, P
Rajesh, M
Mukhopadhyay, P
Batkai, S
Mukhopadhyay, B
Patel, V
Hasko, G
Szabo, C
Mabley, J
Liaudet, L
AF Pacher, Pal
Rajesh, Mohanraj
Mukhopadhyay, Partha
Batkai, Sandor
Mukhopadhyay, Bani
Patel, Vivek
Hasko, Gyoergy
Szabo, Csaba
Mabley, Jon
Liaudet, Lucas
TI Xanthine oxidase inhibitor allopurinol attenuates the development of
diabetic cardiomyopathy
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Pacher, Pal; Rajesh, Mohanraj; Mukhopadhyay, Partha; Batkai, Sandor; Mukhopadhyay, Bani; Patel, Vivek] NIAAA, SOSTI, LPS, NIH, Rockville, MD 20852 USA.
[Hasko, Gyoergy; Szabo, Csaba] UMDNJ New Jersey Med Sch, Dept Surg, Newark, NJ USA.
[Mabley, Jon] Univ Brighton, Sch Pharm & Biomol Sci, Brighton, E Sussex, England.
[Liaudet, Lucas] Univ Lausanne Hosp, Dept Intens Care Med, Lausanne, Switzerland.
RI Batkai, Sandor/H-7983-2014; Liaudet, Lucas/E-1322-2017
OI Liaudet, Lucas/0000-0003-2670-4930
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 990.24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504526
ER
PT J
AU Pacher, P
Rajesh, M
Mukhopadhyay, P
Hasko, G
AF Pacher, Pal
Rajesh, Mohanraj
Mukhopadhyay, Partha
Hasko, Gyoergy
TI Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle
migration and proliferation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Pacher, Pal; Rajesh, Mohanraj; Mukhopadhyay, Partha] NIAAA, SOSTI, LPS, NIH, Rockville, MD 20852 USA.
[Hasko, Gyoergy] UMDNJ New Jersey Med Sch, Dept Surg, Newark, NJ USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 593.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504303
ER
PT J
AU Pacher, P
Mukhopadhyay, P
Pan, H
Rajesh, M
Patel, V
Mukhopadhyay, B
Becker, L
Batkai, S
Gao, B
Hasko, G
AF Pacher, Pal
Mukhopadhyay, Partha
Pan, Hao
Rajesh, Mohanraj
Patel, Vivek
Mukhopadhyay, Bani
Becker, Lauren
Batkai, Sandor
Gao, Bin
Hasko, Gyoergy
TI Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing
oxidative/nitrosative stress, inflammation and cell death
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Pacher, Pal; Mukhopadhyay, Partha; Pan, Hao; Rajesh, Mohanraj; Patel, Vivek; Becker, Lauren] NIAAA, SOSTI, LPS, Rockville, MD 20852 USA.
[Mukhopadhyay, Bani; Batkai, Sandor; Gao, Bin] NIAAA, LPS, NIH, Rockville, MD 20852 USA.
RI Batkai, Sandor/H-7983-2014
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 617.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504103
ER
PT J
AU Pathak, VK
Delviks-Frankenberry, KA
Nikolenko, GN
AF Pathak, Vinay K.
Delviks-Frankenberry, Krista A.
Nikolenko, Galina N.
TI RNase H activity and drug resistance to nucleoside and nonnucleoside
reverse transcriptase inhibitors
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Pathak, Vinay K.; Delviks-Frankenberry, Krista A.; Nikolenko, Galina N.] NCI, HIV Drug Resistance Program, Frederick, MD 21701 USA.
RI Delviks-Frankenberry, Krista/M-4822-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 331.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621503755
ER
PT J
AU Rane, SG
Lin, HM
Lee, JH
Yadav, H
Matschinsky, F
Harlan, DM
AF Rane, Sushil G.
Lin, Huei-Min
Lee, Ji-Hyeon
Yadav, Hariom
Matschinsky, Franz
Harlan, David M.
TI TGF-beta/Smad3 signaling regulates pancreatic islet beta cell function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Rane, Sushil G.; Lin, Huei-Min; Lee, Ji-Hyeon; Yadav, Hariom; Harlan, David M.] NIDDK, Diabet Branch, NIH, Bethesda, MD USA.
[Matschinsky, Franz] Univ Penn, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 856.14
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504844
ER
PT J
AU Reese, J
Mauch, TJ
Paul, W
Nelson, R
Miller, RL
AF Reese, James
Mauch, Teri Jo
Paul, William
Nelson, Raoul
Miller, R. Lance
TI Microarray Analysis of Embryonic Kidneys Following Inactivation of GATA3
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Reese, James; Mauch, Teri Jo; Nelson, Raoul; Miller, R. Lance] Univ Utah, Salt Lake City, UT USA.
[Paul, William] NIA, Inst Allegry & Infect Dis, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 796.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506465
ER
PT J
AU Ren, XF
Kloer, D
Kim, YC
Ghirlando, R
Saidi, LF
Hummer, G
Hurley, JH
AF Ren, Xuefeng
Kloer, Daniel
Kim, Youngchan
Ghirlando, Rodolfo
Saidi, Layla F.
Hummer, Gerhard
Hurley, James H.
TI Hybrid Structural Model of the Complete Human ESCRT-0 Complex
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Ren, Xuefeng; Kloer, Daniel; Kim, Youngchan; Ghirlando, Rodolfo; Saidi, Layla F.; Hummer, Gerhard; Hurley, James H.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 683.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500869
ER
PT J
AU Rojas, AL
Hierro, A
Rojas, R
Murthy, N
Effantin, G
Kajava, A
Steven, A
Bonifacino, J
Hurley, J
AF Rojas, Adriana Lucely
Hierro, Aitor
Rojas, Raul
Murthy, Namita
Effantin, Gregory
Kajava, Andrey
Steven, Alasdair
Bonifacino, Juan
Hurley, James
TI Functional architecture of the retromer cargo-recognition complex
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Rojas, Adriana Lucely; Hierro, Aitor; Hurley, James] NIDDK, LMB, NIH, Bethesda, MD USA.
[Effantin, Gregory; Steven, Alasdair] NIAMSD, NIH, Bethesda, MD 20892 USA.
[Hierro, Aitor] CIC BIOGUNE, Struct Biol Unit, Bilbao, Spain.
[Rojas, Raul; Murthy, Namita; Bonifacino, Juan] NICDH, NIH, Bethesa, MD USA.
[Kajava, Andrey] Univ Montpellier, CNRS, Ctr Rech Biochim Macromol, F-34059 Montpellier, France.
RI Kajava, Andrey/E-1107-2014
OI Kajava, Andrey/0000-0002-2342-6886
NR 0
TC 0
Z9 0
U1 0
U2 6
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 698.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501026
ER
PT J
AU Sachs, AN
Pisitkun, T
Hoffert, JD
Yu, MJ
Knepper, MA
AF Sachs, Aaron N.
Pisitkun, T.
Hoffert, J. D.
Yu, M-J
Knepper, M. A.
TI LC-MS/MS analysis of differential centrifugation fractions from native
inner medullary collecting duct (IMCD) of rat
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Sachs, Aaron N.; Pisitkun, T.; Hoffert, J. D.; Yu, M-J; Knepper, M. A.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 970.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501848
ER
PT J
AU Sengupta, A
Carlson, BA
Labunskyy, V
Gladyshev, VN
Hatfield, DL
AF Sengupta, Aniruddha
Carlson, Bradley A.
Labunskyy, Vyacheslav
Gladyshev, Vadim N.
Hatfield, Dolph L.
TI Knocking down selenoprotein T (SelT) alters cell adhesion and elevates
selenoprotein W (SelW) expression in murine fibroblast cells.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Sengupta, Aniruddha; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, MBSS, LCP, CCR,NIH, Bethesda, MD 20892 USA.
[Labunskyy, Vyacheslav; Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 728.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501188
ER
PT J
AU Shen, WX
Sun, JH
Hockman, S
Khan, F
Manganiello, V
AF Shen, Weixing
Sun, Junhui
Hockman, Steven
Khan, Faiyaz
Manganiello, Vincent
TI PDE3A may regulate myocardial Ca2+cycling through interacting with
SERCA2 in mouse heart
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shen, Weixing; Sun, Junhui; Hockman, Steven; Khan, Faiyaz; Manganiello, Vincent] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 891.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504513
ER
PT J
AU Shi, YB
AF Shi, Yun-Bo
TI Thyroid hormone receptor recruits histone methyltransferase PRMT1 to
regulate transcription and developmental rate
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shi, Yun-Bo] NICHD, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 490.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500449
ER
PT J
AU Stephenson, T
Fearon, P
Cohen-Fix, O
AF Stephenson, Tesia
Fearon, Paula
Cohen-Fix, Orna
TI Identifying Novel Cell Cycle Regulators in Budding Yeast
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Stephenson, Tesia] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
[Fearon, Paula; Cohen-Fix, Orna] NIDDKD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 491.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501683
ER
PT J
AU Subar, AF
Potischman, N
Thompson, FE
Tapia, R
Zimmerman, TP
Hull, S
Mittl, B
Buday, R
Crafts, J
McNutt, S
Guenther, P
Willis, G
Islam, N
Bosire, C
Morrissette, M
Schatzkin, A
Baranowski, T
AF Subar, Amy F.
Potischman, Nancy
Thompson, Frances E.
Tapia, Ramsey
Zimmerman, Thea Palmer
Hull, Stephen
Mittl, Beth
Buday, Richard
Crafts, Jennifer
McNutt, Suzanne
Guenther, Patricia
Willis, Gordon
Islam, Noemi
Bosire, Claire
Morrissette, Meredith
Schatzkin, Arthur
Baranowski, Tom
TI The Automated Self-Administered 24-hour Dietary Recall (ASA24): publicly
available from the National Cancer Institute (NCI)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Subar, Amy F.; Potischman, Nancy; Thompson, Frances E.; Willis, Gordon; Bosire, Claire; Schatzkin, Arthur] NCI, Bethesda, MD 20892 USA.
[Tapia, Ramsey; Buday, Richard] Archimage, Houston, TX USA.
[Zimmerman, Thea Palmer; Hull, Stephen; Mittl, Beth; Crafts, Jennifer; McNutt, Suzanne] Westat Corp, Rockville, MD USA.
[Guenther, Patricia] USDA, Alexandria, VA USA.
[Islam, Noemi; Baranowski, Tom] Baylor Coll Med, Houston, TX 77030 USA.
[Morrissette, Meredith] NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 223.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500766
ER
PT J
AU Sue, L
Fuhrman, BJ
Xu, X
Gail, MH
Falk, RT
Wu, AH
Pike, MC
Keefer, LK
Veenstra, TD
Hoover, RN
Ziegler, RG
AF Sue, Laura
Fuhrman, Barbara J.
Xu, Xia
Gail, Mitchell H.
Falk, Roni T.
Wu, Anna H.
Pike, Malcolm C.
Keefer, Larry K.
Veenstra, Timothy D.
Hoover, Robert N.
Ziegler, Regina G.
TI Relationships between body mass index, endogenous estrogen levels, and
patterns of estrogen metabolism in Asian-American women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Sue, Laura; Fuhrman, Barbara J.; Gail, Mitchell H.; Falk, Roni T.; Hoover, Robert N.; Ziegler, Regina G.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Xu, Xia; Veenstra, Timothy D.] SAIC Frederick Inc, Frederick, MD USA.
[Wu, Anna H.; Pike, Malcolm C.] Univ So Calif, Sch Med, Los Angeles, CA USA.
[Keefer, Larry K.] NCI, Comparat Carcinogenesis Lab, Frederick, MD 21701 USA.
RI Keefer, Larry/N-3247-2014
OI Keefer, Larry/0000-0001-7489-9555
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 551.33
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504775
ER
PT J
AU Tanda, G
Garces-Ramirez, L
Green, JL
Hiranita, T
Katz, JL
AF Tanda, Gianluigi
Garces-Ramirez, Linda
Green, Jennifer L.
Hiranita, Takato
Katz, Jonathan L.
TI Effects of Acute Administration of Sigma Receptor Ligands on Mesolimbic
Dopamine Neurotransmission in Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tanda, Gianluigi; Garces-Ramirez, Linda; Green, Jennifer L.; Hiranita, Takato; Katz, Jonathan L.] NIDA, Medicat Discovery Res Branch, Baltimore, MD USA.
RI Tanda, Gianluigi/B-3318-2009; Hiranita, Takato/G-6567-2011
OI Tanda, Gianluigi/0000-0001-9526-9878;
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 745.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505834
ER
PT J
AU Tauseef, M
Knezevic, N
Malik, AB
Abramowitz, J
Birnbaumer, L
Mehta, D
AF Tauseef, Mohammad
Knezevic, Nebojsa
Malik, Asrar B.
Abramowitz, Joel
Birnbaumer, Lutz
Mehta, Dolly
TI TRPC1-Mediated Ca2+Entry Increases Lung Microvascular Permeability
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tauseef, Mohammad; Knezevic, Nebojsa; Malik, Asrar B.; Mehta, Dolly] Univ Illinois, Chicago, IL USA.
[Abramowitz, Joel; Birnbaumer, Lutz] NIEHS, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 964.9
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505335
ER
PT J
AU Topanurak, S
Gallazini, M
Ferraris, JD
Burg, MB
AF Topanurak, Supachai
Gallazini, Morgan
Ferraris, Joan D.
Burg, Maurice B.
TI Role of Phosphorylation in the Inhibition of GDPD5 Activity that
Contributes to High NaCl- and Urea-induced Increase of GPC
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Topanurak, Supachai; Gallazini, Morgan; Ferraris, Joan D.; Burg, Maurice B.] NHLBI, Kidney & Electrolyte Metab Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1001.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501189
ER
PT J
AU Trasino, S
Kim, YS
Wang, TTY
AF Trasino, Steven
Kim, Young S.
Wang, Thomas T. Y.
TI Cancer preventive phytochemicals uniquely activate liver x receptor
responsive genes through receptor dependent and independent mechanisms
in prostate cancer cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Trasino, Steven; Wang, Thomas T. Y.] USDA, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA.
[Kim, Young S.] NCI, Nutr Sci Res Grp, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 717.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502452
ER
PT J
AU Tsuji, PA
Irons, R
Ouyang, P
Carlson, B
Yoo, MH
Xu, XM
Hatfield, D
Gladyshev, V
Davis, C
AF Tsuji, Petra A.
Irons, Robert
Ouyang, Ping
Carlson, Bradley
Yoo, Min-Hyuk
Xu, Xue-Ming
Hatfield, Dolph
Gladyshev, Vadim
Davis, Cindy
TI Sep15 knockdown decreases tumorigenicity and metastasis of a colon
cancer cell line
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tsuji, Petra A.] NCI, Canc Prevent Fellowship Program, Rockville, MD USA.
[Ouyang, Ping; Davis, Cindy] NCI, Div Canc Prevent, Rockville, MD USA.
[Tsuji, Petra A.; Ouyang, Ping; Carlson, Bradley; Yoo, Min-Hyuk; Xu, Xue-Ming; Hatfield, Dolph] NCI, MBSS, LCP, Bethesda, MD 20892 USA.
[Irons, Robert] VE Irons Inc, Kansas City, MO USA.
[Gladyshev, Vadim] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 338.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502473
ER
PT J
AU Tuan, RS
AF Tuan, Rocky S.
TI Adult Stem Cells and Nanomaterials for Skeletal Tissue Engineering and
Regeneration
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 69.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500238
ER
PT J
AU Tuo, JS
Cho, Y
Chew, E
Chan, CC
AF Tuo, Jingsheng
Cho, Youngeun
Chew, Emily
Chan, Chi-Chao
TI A variant in 5-UTR of ERCC6 protects against age-related macular
degeneration in European decent
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tuo, Jingsheng; Cho, Youngeun; Chan, Chi-Chao] NEI, Immunol Lab, Bethesda, MD 20892 USA.
[Chew, Emily] NEI, Div Epidemiol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 926.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500587
ER
PT J
AU Tycko, R
AF Tycko, Robert
TI Molecular structure of amyloid and prion fibrils
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Tycko, Robert] NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 423.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500331
ER
PT J
AU Ungvari, Z
Labinskyy, N
Podlutsky, A
Austad, S
Mukhopadhyay, P
Pacher, P
Bartke, A
Csiszar, A
AF Ungvari, Zoltan
Labinskyy, Nazar
Podlutsky, Andrej
Austad, Steven
Mukhopadhyay, Partha
Pacher, Pal
Bartke, Andrzej
Csiszar, Anna
TI Endothelial function and vascular oxidative stress in long-lived
GH/IGF-deficient Ames dwarf mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Ungvari, Zoltan; Labinskyy, Nazar; Csiszar, Anna] New York Med Coll, Valhalla, NY 10595 USA.
[Podlutsky, Andrej; Austad, Steven] Univ Texas San Antonio, San Antonio, TX USA.
[Mukhopadhyay, Partha; Pacher, Pal] NIAAA, Bethesda, MD USA.
[Bartke, Andrzej] So Illinois Univ, Sch Med, Springfield, IL USA.
RI Podlutsky, Andrej/F-5421-2015; Bartke, Andzej/D-6640-2017
OI Bartke, Andzej/0000-0002-2569-557X
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 595.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505295
ER
PT J
AU Ungvari, Z
Labinskyy, N
Pacher, P
Mukhopadhyay, P
Podlutsky, A
Austad, S
Csiszar, A
AF Ungvari, Zoltan
Labinskyy, Nazar
Pacher, Pal
Mukhopadhyay, Partha
Podlutsky, Andrej
Austad, Steven
Csiszar, Anna
TI Longevity is associated with increased vascular resistance to metabolic
stress in P. leucopus
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Ungvari, Zoltan; Labinskyy, Nazar; Csiszar, Anna] New York Med Coll, Valhalla, NY 10595 USA.
[Pacher, Pal; Mukhopadhyay, Partha] NIAAA, Bethesda, MD USA.
[Podlutsky, Andrej; Austad, Steven] Univ Texas San Antonio, San Antonio, TX USA.
RI Podlutsky, Andrej/F-5421-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 595.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504666
ER
PT J
AU Wang, K
Forbes, JG
Wittebort, RJ
Yadavalli, VK
Tsai, WXL
AF Wang, Kuan
Forbes, Jeffrey G.
Wittebort, Richard J.
Yadavalli, Vamsi K.
Tsai, Wanxia L.
TI Nanomechanics of intrinsically disordered proteins in signaling pathways
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Forbes, Jeffrey G.; Yadavalli, Vamsi K.; Tsai, Wanxia L.] NIAMS, Lab Muscle Biol, NIH, Bethesda, MD USA.
[Wittebort, Richard J.] Univ Louisville, Louisville, KY 40292 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 296.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501889
ER
PT J
AU Wang, MY
Lakatta, EG
AF Wang, Mingyi
Lakatta, Edward G.
TI Central Arterial Aging: Humans to Molecules
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Mingyi; Lakatta, Edward G.] NIA, LCS, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 414.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500006
ER
PT J
AU Wang, YF
Beydoun, MA
AF Wang, Youfa
Beydoun, May A.
TI Sociodemographic disparities in adiposity distribution shifts in
American children and adolescents
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Youfa; Beydoun, May A.] Johns Hopkins Univ, Ctr Human Nutr, Baltimore, MD USA.
[Beydoun, May A.] NIA, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 551.34
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504829
ER
PT J
AU Wang, ZF
Wang, Y
Cheong, CG
Hall, TM
AF Wang, Zefeng
Wang, Yang
Cheong, Cheom-Gil
Hall, Traci M.
TI Engineering artificial splicing factors with designed specificities
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Zefeng; Wang, Yang] UNC, Dept Pharmacol, Chapel Hill, NC 27599 USA.
[Cheong, Cheom-Gil; Hall, Traci M.] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 662.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502517
ER
PT J
AU Wang, ZF
Wang, Y
Cheong, CG
Hall, TM
AF Wang, Zefeng
Wang, Yang
Cheong, Cheom-Gil
Hall, Traci M.
TI Engineering artificial splicing factors with designed specificities
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Zefeng; Wang, Yang] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA.
[Cheong, Cheom-Gil; Hall, Traci M.] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Cheong, Cheom-Gil] Univ N Carolina, Chapel Hill, NC 27599 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 662.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502576
ER
PT J
AU Wazen, RM
Moffatt, P
Zalzal, SF
Yamada, Y
Nanci, A
AF Wazen, Rima Marie
Moffatt, Pierre
Zalzal, Sylvia Francis
Yamada, Yoshihiko
Nanci, Antonio
TI Dental phenotype of a mouse model expressing a truncated form of
ameloblastin
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wazen, Rima Marie; Zalzal, Sylvia Francis; Nanci, Antonio] Univ Montreal, Montreal, PQ, Canada.
[Moffatt, Pierre] Montreal Shriners Hosp Children, Montreal, PQ, Canada.
[Yamada, Yoshihiko] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 651.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621503750
ER
PT J
AU Weeks, K
Watts, J
Wilkinson, K
Gorelick, R
AF Weeks, Kevin
Watts, Joseph
Wilkinson, Kevin
Gorelick, Robert
TI High-Throughput Analysis of RNA Structure by SHAPE Chemistry
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Weeks, Kevin; Watts, Joseph; Wilkinson, Kevin] Univ N Carolina, Chapel Hill, NC USA.
[Gorelick, Robert] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 326.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501804
ER
PT J
AU Wess, J
de Azua, IR
Gautam, D
Scarselli, M
Rosemond, E
Cui, YH
Guettier, JM
AF Wess, Juergen
de Azua, Inigo Ruiz
Gautam, Dinesh
Scarselli, Marco
Rosemond, Erica
Cui, Yinghong
Guettier, Jean-Marc
TI G Protein-Coupled Receptor (GPCR) Signaling Pathways in Beta-Cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wess, Juergen; de Azua, Inigo Ruiz; Gautam, Dinesh; Scarselli, Marco; Rosemond, Erica; Cui, Yinghong; Guettier, Jean-Marc] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 329.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500512
ER
PT J
AU Wilger-Gahche, JJ
Bailey, RL
Burt, VL
Radimer, K
McDowell, M
Picciano, MF
Dwyer, J
Sempos, C
AF Wilger-Gahche, Jaime Jacqueline
Bailey, Regan Lucas
Burt, Vicki L.
Radimer, Kathy
McDowell, Margaret
Picciano, Mary Frances
Dwyer, Johanna
Sempos, Chris
TI Mean daily intake of calcium, folate and vitamin D from dietary
supplements and the proportion getting above certain Dietary Reference
Intake (DRI) levels, in the US population ages 14 years and older: Third
National Health and Nutrition Examination Survey (NHANES III) and
NHANES, 1999-2006
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wilger-Gahche, Jaime Jacqueline; Burt, Vicki L.; Radimer, Kathy; McDowell, Margaret] Natl Ctr Hlth Stat, DHNES, Hyattsville, MD 20782 USA.
[Bailey, Regan Lucas; Picciano, Mary Frances; Dwyer, Johanna; Sempos, Chris] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 341.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621504437
ER
PT J
AU Wong, R
Steenbergen, C
Murphy, E
AF Wong, Renee
Steenbergen, Charles
Murphy, Elizabeth
TI Cardioprotection increases phosphorylation of the mitochondrial electron
transport chain and promotes supercomplex formation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wong, Renee; Murphy, Elizabeth] NHLBI, NIH, Bethesda, MD 20892 USA.
[Steenbergen, Charles] Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 508.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501640
ER
PT J
AU Xu, XM
Ganichkin, OM
Carlson, BA
Gladyshev, VN
Wahl, M
Hatfield, DL
AF Xu, Xue-Ming
Ganichkin, Oleg M.
Carlson, Bradley A.
Gladyshev, Vadim N.
Wahl, Markus
Hatfield, Dolph L.
TI Catalytic Mechanism of Eukaryotic Selenocysteine Synthase
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Xu, Xue-Ming; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, CCR LCP, NIH, Bethesda, MD 20892 USA.
[Ganichkin, Oleg M.; Wahl, Markus] Max Planck Inst, Gottingen, Germany.
[Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
RI Gladyshev, Vadim/A-9894-2013
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 338.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500839
ER
PT J
AU Yan, ZJ
Xu, DY
Guo, R
Xue, YT
Ling, C
Li, YJ
Wang, WD
AF Yan, Zhijiang
Xu, Dongyi
Guo, Rong
Xue, Yutong
Ling, Chen
Li, Yongjiang
Wang, Weidong
TI A Complex Involved in the DNA Damage Response Network of Fanconi Anemia
and Breast Cancer
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yan, Zhijiang; Xu, Dongyi; Guo, Rong; Xue, Yutong; Ling, Chen; Li, Yongjiang; Wang, Weidong] NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 429.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500339
ER
PT J
AU Yang, D
Rismanchi, N
Renvoise, B
Lippincott-Schwartz, J
Blackstone, C
Hurley, J
AF Yang, Dong
Rismanchi, Neggy
Renvoise, Benoit
Lippincott-Schwartz, Jennifer
Blackstone, Craig
Hurley, James
TI Structural basis for midbody targeting of spastin by the ESCRT-III
protein CHMP1B
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yang, Dong; Rismanchi, Neggy; Renvoise, Benoit; Lippincott-Schwartz, Jennifer; Blackstone, Craig; Hurley, James] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 864.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500862
ER
PT J
AU Yang, W
Wang, F
AF Yang, Wei
Wang, Feng
TI Translesion DNA synthesis by replicative-like polymerases
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yang, Wei; Wang, Feng] NIH, LMB, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 315.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621503117
ER
PT J
AU Yang, XR
Cao, YN
Birnbaumer, L
Sham, JSK
AF Yang, Xiao-Ru
Cao, Yuan-Ning
Birnbaumer, Lutz
Sham, James S. K.
TI TRPC1 contribute to hypoxic pulmonary hypertension and right heart
hypertrophy: evidence from TRPC1 knockout mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yang, Xiao-Ru; Cao, Yuan-Ning; Sham, James S. K.] Johns Hopkins Med Inst, Div Pulm Med, Baltimore, MD 21205 USA.
[Birnbaumer, Lutz] NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 619.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621505523
ER
PT J
AU Yoo, MH
Xu, XM
Carlson, BA
Gladyshev, VN
Hatfield, DL
AF Yoo, Min-Hyuk
Xu, Xue-Ming
Carlson, Bradley A.
Gladyshev, Vadim N.
Hatfield, Dolph L.
TI Increased sensitivity of thioredoxin reductase 1 deficient breast cancer
cells against TNF-alpha induced apoptosis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yoo, Min-Hyuk; Xu, Xue-Ming; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, CCR LCP, NIH, Bethesda, MD 20892 USA.
[Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 338.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502433
ER
PT J
AU Yu, MJ
Rinschen, MM
Khositseth, S
Braucht, DWW
Uawithya, P
Chou, CL
Pisitkun, T
Knepper, MA
AF Yu, Ming-Jiun
Rinschen, M. M.
Khositseth, S.
Braucht, D. W. W.
Uawithya, P.
Chou, C-L
Pisitkun, T.
Knepper, M. A.
TI Systems Level Analysis of Cell-Specific AQP2 Gene Expression in
Collecting Duct
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yu, Ming-Jiun; Rinschen, M. M.; Khositseth, S.; Braucht, D. W. W.; Uawithya, P.; Chou, C-L; Pisitkun, T.; Knepper, M. A.] NHLBI, LKEM, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 998.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506716
ER
PT J
AU Yu, MJ
Rinschen, MM
Khositseth, S
Braucht, DWW
Uawithya, P
Chou, CL
Pisitkun, T
Knepper, MA
AF Yu, Ming-Jiun
Rinschen, M. M.
Khositseth, S.
Braucht, D. W. W.
Uawithya, P.
Chou, C-L
Pisitkun, T.
Knepper, M. A.
TI Systems Level Analysis of Cell-Specific AQP2 Gene Expression in
Collecting Duct
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Yu, Ming-Jiun; Rinschen, M. M.; Khositseth, S.; Braucht, D. W. W.; Uawithya, P.; Chou, C-L; Pisitkun, T.; Knepper, M. A.] NHLBI, LKEM, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 998.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621506847
ER
PT J
AU Zhang, ZY
Lanza, E
Bagshaw, D
Colburn, N
Ross, AC
Rovine, M
Hartman, T
AF Zhang, Zhiying
Lanza, Elaine
Bagshaw, Deborah
Colburn, Nancy
Ross, A. Catharine
Rovine, Michael
Hartman, Terry
TI The Legume Inflammation Feeding Experiment (LIFE): Effects of Gut
Hormone Levels
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zhang, Zhiying; Bagshaw, Deborah; Ross, A. Catharine; Rovine, Michael; Hartman, Terry] Penn State Univ, University Pk, PA 16802 USA.
[Lanza, Elaine] NCI, Bethesda, MD 20892 USA.
[Colburn, Nancy] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 898.9
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621502312
ER
PT J
AU Zhao, K
AF Zhao, Keji
TI Chromatin signatures in multipotent hematopoietic stem cells indicate
fate of bivalent genes during differentiation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zhao, Keji] NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 421.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500556
ER
PT J
AU Zhou, XM
Ferraris, JD
Burg, MB
AF Zhou, Xiaoming
Ferraris, Joan D.
Burg, Maurice B.
TI Genome-wide RNA interference screen for phosphatases that contribute to
regulation of the transcription factor TonEBP/OREBP
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zhou, Xiaoming] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Ferraris, Joan D.; Burg, Maurice B.] NIH, LKEM, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 1001.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501122
ER
PT J
AU Zou, TT
Rao, JN
Liu, L
Xiao, L
Yu, TX
Wang, PY
Zhang, X
Gorospe, M
Wang, JY
AF Zou, Tongtong
Rao, Jaladanki N.
Liu, Lan
Xiao, Lan
Yu, Tingxi
Wang, Pengyuan
Zhang, Xian
Gorospe, Myriam
Wang, Jian-Ying
TI HuR and AUF1 Competitively Bind to the JunD mRNA and Regulate its
Stability in Intestinal Epithelial Cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zou, Tongtong; Rao, Jaladanki N.; Liu, Lan; Xiao, Lan; Yu, Tingxi; Wang, Pengyuan; Zhang, Xian; Wang, Jian-Ying] Univ Maryland, Dept Surg, Baltimore, MD 21201 USA.
[Wang, Jian-Ying] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
[Gorospe, Myriam] NIA, Cellular & Mol Biol Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 979.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500757
ER
PT J
AU Zwang, N
Hoffert, J
Pisitkun, T
Moeller, H
Fenton, R
Knepper, M
AF Zwang, Nicholas
Hoffert, J.
Pisitkun, T.
Moeller, H.
Fenton, R.
Knepper, M.
TI Identification of Phosphorylation-Dependent Binding Partners of
Aquaporin-2 (AQP2) By Protein Mass Spectrometry
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zwang, Nicholas; Hoffert, J.; Pisitkun, T.; Knepper, M.] NHLBI, Bethesda, MD 20892 USA.
[Moeller, H.; Fenton, R.] U Aarhus, Aarhus, Denmark.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 998.33
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621501734
ER
PT J
AU Pomerantsev, AP
Pomerantseva, OM
Camp, AS
Mukkamala, R
Goldman, S
Leppla, SH
AF Pomerantsev, Andrei P.
Pomerantseva, Olga M.
Camp, Andrew S.
Mukkamala, Radhika
Goldman, Stanley
Leppla, Stephen H.
TI PapR peptide maturation: role of the NprB protease in Bacillus cereus
569 PlcR/PapR global gene regulation
SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
LA English
DT Article
DE Bacillus cereus; Bacillus anthracis; PlcR; PapR regulation; quorum
sensing; protease; peptide
ID SIGNALING PEPTIDE; PHOSPHOLIPASE-C; LETHAL FACTOR; PLCR REGULON;
ANTHRACIS; THURINGIENSIS; VIRULENCE; SUBTILIS; BACTERIA; SEQUENCE
AB The global transcriptional regulator PlcR controls gene expression in Bacillus cereus and Bacillus thuringiensis. Activity of PlcR is regulated by PapR, the product of an ORF located immediately downstream of plcR. To be active in B. cereus, PapR must be secreted and then processed to the mature peptide by an unknown protease. This peptide is transported by an oligopeptide permease into the cell, where it activates PlcR. In this study, we show that the neutral protease B (NprB) secreted by B. cereus 569 is required for extracellular PapR maturation. Purified recombinant NprB processed the synthetic PapR propeptide to produce a set of peptides derived from the C-terminal domain of PapR. Supplementation of growth media with synthetic PapR-derived C-terminal 5-, 7-, 8- and 27-amino acid (aa) peptides caused activation of intracellular PlcR in a PapR-deficient strain of B. cereus 569 while only the 5- and 7-aa peptides activated PlcR in a nprB mutant. The maximum activity was found for the 7-mer peptide. However, even the 7-mer peptide could not activate PlcR with a C-terminal truncation of as few as 6 aa. This indicates that interactions of the C-terminal regions of both PlcR and PapR are important in transcriptional activation of the B. cereus 569 PlcR regulon.
C1 [Pomerantsev, Andrei P.; Camp, Andrew S.; Mukkamala, Radhika; Leppla, Stephen H.] NIAID, Lab Bacterial Dis, NIH, Bethesda, MD 20892 USA.
[Pomerantseva, Olga M.; Goldman, Stanley] USN, Biol Def Res Directorate, Med Res Ctr, Rockville, MD USA.
RP Leppla, SH (reprint author), NIAID, Lab Bacterial Dis, NIH, Bethesda, MD 20892 USA.
EM sleppla@niaid.nih.gov
FU Intramural Research Program of the NIH, National Institute of Allergy
and Infectious Diseases
FX We thank M. Garfield and J. Lukszo from the NIAID core facility for
peptide synthesis and protein sequencing as well as Dr Nga Nguyen from
the FDA core facility for assistance with MS analysis. We also
acknowledge T. Read for the disclosure of the B. cereus 569 chromosomal
sequences and K. Beliakov for assistance with the figure formatting.
This research was supported by the Intramural Research Program of the
NIH, National Institute of Allergy and Infectious Diseases.
NR 35
TC 9
Z9 11
U1 2
U2 10
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0928-8244
J9 FEMS IMMUNOL MED MIC
JI FEMS Immunol. Med. Microbiol.
PD APR
PY 2009
VL 55
IS 3
BP 361
EP 377
DI 10.1111/j.1574-695X.2008.00521.x
PG 17
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 416RA
UT WOS:000264022000009
PM 19159431
ER
PT J
AU Levens, ED
Whitcomb, BW
Payson, MD
Larsen, FW
AF Levens, Eric D.
Whitcomb, Brian W.
Payson, Mark D.
Larsen, Frederick W.
TI Ovarian follicular flushing among low-responding patients undergoing
assisted reproductive technology
SO FERTILITY AND STERILITY
LA English
DT Article; Proceedings Paper
CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 13-17, 2007
CL Washington, DC
SP Amer Soc Reprod Med
ID DIRECTED OOCYTE RECOVERY; ASPIRATION; ULTRASOUND; RETRIEVAL; FOLLICLES;
NEEDLES
AB A randomized comparison trial was performed to evaluate whether follicular reaspiration with use of a double-lumen retrieval needle improves oocyte recovery when compared with direct follicular aspiration among low-responding patients undergoing ART. There were no differences observed in the number of oocytes retrieved (single lumen: 6.5 +/- 2.2 oocytes, double lumen: 7.2 +/- 2.3 oocytes) whereas follicular reaspiration with the double-lumen retrieval needle resulted in a twofold increase in procedure time. (Fertil Steril (R) 2009;91: 1381-4. (C) 2009 by American Society for Reproductive Medicine.)
C1 [Levens, Eric D.] NICHHD, NIH, Reprod Biol & Med Branch, Bethesda, MD 20892 USA.
[Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA.
[Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] NIH, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA.
[Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Whitcomb, Brian W.] NICHHD, NIH, Epidemiol Branch, Bethesda, MD 20892 USA.
RP Levens, ED (reprint author), NICHHD, NIH, Reprod Biol & Med Branch, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA.
EM levense@mail.nih.gov
FU Intramural NIH HHS [Z99 HD999999]
NR 14
TC 14
Z9 14
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2009
VL 91
IS 4
BP 1381
EP 1384
DI 10.1016/j.fertnstert.2008.04.034
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 432KT
UT WOS:000265132600026
PM 18675970
ER
PT J
AU Duncan, FE
Stein, P
Williams, CJ
Schultz, RM
AF Duncan, Francesca E.
Stein, Paula
Williams, Carmen J.
Schultz, Richard M.
TI The effect of blastomere biopsy on preimplantation mouse embryo
development and global gene expression
SO FERTILITY AND STERILITY
LA English
DT Article
ID IN-VITRO; DIAGNOSIS; IMPLANTATION; CULTURE; INVITRO; STAGE
AB The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching. (Fertil Steril (R) 2009;91:1462-5. (C) 2009 by American Society for Reproductive Medicine.)
C1 [Duncan, Francesca E.; Stein, Paula; Schultz, Richard M.] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA.
[Duncan, Francesca E.] Univ Penn, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA.
[Williams, Carmen J.] NIEHS, Res Triangle Pk, NC 27709 USA.
RP Schultz, RM (reprint author), Univ Penn, Dept Biol, Philadelphia, PA 19104 USA.
EM rschultz@sas.upenn.edu
FU NIH [U01 HD 44575, T32 HD 007305 22]
FX Supported by a grant from the NIH (U01 HD 44575) to R.M.S. F.E.D. was
supported by a training grant from the NIH (T32 HD 007305 22). This work
was done in the Department of Biology at the University of Pennsylvania.
NR 18
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2009
VL 91
IS 4
BP 1462
EP 1465
DI 10.1016/j.fertnstert.2008.07.1710
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 432KT
UT WOS:000265132600050
PM 18774571
ER
PT J
AU Browne, H
Armstrong, A
DeCherney, A
Babb, R
Illei, G
Segars, J
Pavletic, S
AF Browne, Hyacinth
Armstrong, Alicia
DeCherney, Alan
Babb, Rebecca
Illei, Gabor
Segars, James
Pavletic, Steven
TI Assessment of ovarian function with anti-Mullerian hormone in systemic
lupus erythematosus patients undergoing hematopoietic stem cell
transplant
SO FERTILITY AND STERILITY
LA English
DT Article
DE Stem cell transplant; ovarian reserve; anti-Mullerian hormone
ID ASSISTED REPRODUCTIVE TECHNOLOGY; CHILDHOOD-CANCER; INHIBIN-B;
BREAST-CANCER; RESERVE; WOMEN; CHEMOTHERAPY; SURVIVORS; SUBSTANCE;
CYCLES
AB In this small pilot study, anti-Mullerian hormone (AMH) levels in women undergoing chemotherapy and hematopoietic stem cell transplantation facilitated earlier identification of impaired ovarian reserve compared with FSH and the resumption of menses. Larger studies are needed to accurately assess the clinical significance of AMH levels in the prediction of long-term reproductive outcomes in reproductive-age transplant patients with our current conditioning regimen. (Fertil Steril (R) 2009;91:1529-32. (C)2009 by American Society for Reproductive Medicine.)
C1 [Browne, Hyacinth] NICHD, Program Reprod & Adult Endocrinol, CRC, NIH, Bethesda, MD 20892 USA.
[Babb, Rebecca; Pavletic, Steven] NCI, NIH, Bethesda, MD 20892 USA.
[Illei, Gabor] Natl Inst Dental & Craniofacial Res, NIH, Bethesda, MD USA.
RP Browne, H (reprint author), NICHD, Program Reprod & Adult Endocrinol, CRC, NIH, Room 1-E-3140,10 Ctr Dr, Bethesda, MD 20892 USA.
EM brownehy@mail.nih.gov
FU National Institute of Child Health and Human Development; National
Cancer Institute; National Institute of Dental and Craniofacial
Research, NIH
FX Supported in part by the intramural research program of the Program in
Reproductive and Adult Endocrinology of the National Institute of Child
Health and Human Development, the National Cancer Institute, and the
National Institute of Dental and Craniofacial Research, NIH.
NR 14
TC 10
Z9 10
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2009
VL 91
IS 4
BP 1529
EP 1532
DI 10.1016/j.fertnstert.2008.08.123
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 432KT
UT WOS:000265132600070
PM 18930199
ER
PT J
AU Stout, MD
Nyska, A
Collins, BJ
Witt, KL
Kissling, GE
Malarkey, DE
Hooth, MJ
AF Stout, M. D.
Nyska, A.
Collins, B. J.
Witt, K. L.
Kissling, G. E.
Malarkey, D. E.
Hooth, M. J.
TI Chronic toxicity and carcinogenicity studies of chromium picolinate
monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2
years
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Trivalent chromium; Diet; Supplement; Body weight; Preputial gland;
National Toxicology Program
ID HAMSTER OVARY CELLS; PRODUCE CHROMOSOME-DAMAGE; TISSUE LEVELS; DNA
ADDUCTS; IN-VITRO; MUTAGENICITY; ABSORPTION; MORTALITY; ASCORBATE;
EXPOSURE
AB Trivalent chromium (Cr(III)) has been proposed to be an essential element, which may increase sensitivity to insulin and thus participate in carbohydrate and lipid metabolism. Humans ingest Cr(III) both as a natural dietary constituent and in dietary supplements taken for weight loss and antidiabetic effects. Chromium picolinate (CP), a widely used supplement, contains Cr(III) chelated with three molecules of picolinic acid and was formulated in an attempt to improve the absorption of Cr(III). In order to examine the potential for CP to induce chronic toxicity and carcinogenicity, the NTP conducted studies of the monohydrate form (CPM) in groups of 50 male and female F344/N rats and B6C3F1 mice exposed in feed to concentrations of 0, 2000, 10,000 or 50,000 ppm for 2 years; exposure concentrations were selected following review of the data from NTP 3-month toxicity studies. Exposure to CPM did not induce biologically significant changes in survival, body weight, feed consumption, or non-neoplastic lesions in rats or mice. In male rats, a statistically significant increase in the incidence of preputial gland adenoma at 10,000 ppm was considered an equivocal finding. CPM was not carcinogenic to female rats or to male or female mice. Published by Elsevier Ltd.
C1 [Stout, M. D.; Collins, B. J.; Witt, K. L.; Kissling, G. E.; Malarkey, D. E.; Hooth, M. J.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
RP Stout, MD (reprint author), NIEHS, Natl Toxicol Program, POB 12233,MD EC-34, Res Triangle Pk, NC 27709 USA.
EM stoutm@niehs.nih.gov
FU Research Program of the NIH; NIEHS [1 Z01 ES045004-11 BB]
FX This research was supported in part by the intramural Research Program
of the NIH, NIEHS under Research Project Number 1 Z01 ES045004-11 BB.
The authors thank Drs. Ronald Melnick and Scott Auerbach for their
critical review of this manuscript.
NR 53
TC 39
Z9 42
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD APR
PY 2009
VL 47
IS 4
BP 729
EP 733
DI 10.1016/j.fct.2009.01.006
PG 5
WC Food Science & Technology; Toxicology
SC Food Science & Technology; Toxicology
GA 425FS
UT WOS:000264623000010
PM 19166900
ER
PT J
AU Gomez-Mejiba, SE
Zhai, Z
Akram, H
Deterding, LJ
Hensley, K
Smith, N
Tomer, RA
Tomer, KB
Mason, RP
Ramirez, DC
AF Gomez-Mejiba, Sandra E.
Zhai, Zili
Akram, Hammad
Deterding, Leesa J.
Hensley, Kenneth
Smith, Nataliya
Tomer, Rheal A.
Tomer, Kenneth B.
Mason, Ronald P.
Ramirez, Dario C.
TI Immuno-spin trapping of protein and DNA radicals: "Tagging" free
radicals to locate and understand the redox process
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Reactive oxygen species; Free radicals; Spin trap; Immuno-spin trapping;
Immunoassay; Mass spectrometry; Confocal microscopy; Molecular resonance
imaging
ID IN-VIVO DETECTION; HYDROGEN-PEROXIDE; MASS-SPECTROMETRY; OXIDATIVE
DAMAGE; POTENTIAL MECHANISM; MEDIATED OXIDATION; TRYPANOSOMA-CRUZI;
ELECTRON-TRANSFER; CYTOCHROME-C; IDENTIFICATION
AB Biomolecule-centered radicals are intermediate species produced during both reversible (redox modulation) and irreversible (oxidative stress) oxidative modification of biomolecules. These oxidative processes must be Studied in situ and in real time to understand the molecular mechanism of cell adaptation or death in response to changes in the extracellular environment. In this regard, we have developed and validated immuno-spin trapping to tag the redox process, tracing the oxidatively generated modification of biomolecules, in situ and in real time, by detecting protein- and DNA-centered radicals. The purpose of this methods article is to introduce and Update the basic methods and applications of immuno-spin trapping for the study of redox biochemistry in oxidative stress and redox regulation. We describe in detail the production, detection, and location of protein and DNA radicals in biochemical systems, cells, and tissues, and in the whole animal as well, by using immuno-spin trapping with the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Gomez-Mejiba, Sandra E.; Zhai, Zili; Akram, Hammad; Hensley, Kenneth; Ramirez, Dario C.] Oklahoma Med Res Fdn, Free Rad Biol & Aging Res Program, Oklahoma City, OK 73104 USA.
[Deterding, Leesa J.; Tomer, Rheal A.] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Smith, Nataliya; Tomer, Rheal A.] Oklahoma Med Res Fdn, Adv Magnet Resonance Ctr, Oklahoma City, OK 73104 USA.
[Mason, Ronald P.] NIEHS, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Ramirez, DC (reprint author), Oklahoma Med Res Fdn, Free Rad Biol & Aging Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
EM dario-ramirez@omrf.org
RI Tomer, Kenneth/E-8018-2013; Akram, Hammad/P-5294-2015; RAMIREZ,
DARIO/K-3312-2013
OI Akram, Hammad/0000-0002-2882-2335; RAMIREZ, DARIO/0000-0001-6725-3326
FU National institute of Environmental Health Sciences [R00ES015415];
Intramural Research Program of the NIEHS/NIH; Presbyterian Health
Foundation
FX The project described was supported by Award No. R00ES015415 from the
National institute of Environmental Health Sciences and, in part, by the
Intramural Research Program of the NIEHS/NIH. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the National Institute of Environmental Health
Sciences or the National Institutes of Health. D. C.R. also acknowledges
a start-up grant from the Presbyterian Health Foundation to OMRF. The
authors acknowledge Dr. Kalina Ranguelova, Dr. Hugo Cerecetto, Dr. Luke
Szweda, and Dr. Michael Kinter for critical review, and M.S. Quentin
Pye, Dr. Anti Motten, and Ms. Mary J. Mason for help in the editing, of
this article.
NR 63
TC 32
Z9 32
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR 1
PY 2009
VL 46
IS 7
BP 853
EP 865
DI 10.1016/j.freeradbiomed.2008.12.020
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 423KK
UT WOS:000264495000001
PM 19159679
ER
PT J
AU Everhart, JE
Ruhl, CE
AF Everhart, James E.
Ruhl, Constance E.
TI Burden of Digestive Diseases in the United States Part III: Liver,
Biliary Tract, and Pancreas
SO GASTROENTEROLOGY
LA English
DT Review
C1 [Everhart, James E.] NIDDK, Div Digest Dis & Nutr, Bethesda, MD 20892 USA.
Social & Sci Syst Inc, Silver Spring, MD USA.
RP Everhart, JE (reprint author), NIDDK, Div Digest Dis & Nutr, 2 Democracy Plaza,Room 655,6707 Democracy Blvd,MS, Bethesda, MD 20892 USA.
EM JE17G@nih.gov
NR 5
TC 203
Z9 205
U1 4
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD APR
PY 2009
VL 136
IS 4
BP 1134
EP 1144
PG 11
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 426OB
UT WOS:000264716500005
PM 19245868
ER
PT J
AU Yao, MD
von Rosenvinge, EC
Groden, C
Mannon, PJ
AF Yao, Michael D.
von Rosenvinge, Erik C.
Groden, Catherine
Mannon, Peter J.
TI Multiple endoscopic biopsies in research subjects: safety results from a
National Institutes of Health series
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article; Proceedings Paper
CT Digestive Disease Week Meeting/109th Annual Meeting of the
American-Gastroenterological-Association
CY MAY 17-22, 2008
CL San Diego, CA
SP Amer Gastroenterol Assoc
ID GASTROINTESTINAL-ENDOSCOPY; COLONIC HEMORRHAGE; ULCERATIVE-COLITIS; COLD
BIOPSY; COMPLICATIONS; COLONOSCOPY
AB Background: Routine endoscopic mucosal biopsies are generally considered safe. However, the outcomes of performing large numbers of biopsies in Subjects enrolled in research protocols have not been reported.
Objective: Our purpose was to assess the safety of taking numerous mucosal biopsy specimens during endoscopic procedures (eg, >20/endoscopic procedure) in research subjects.
Design: Single-center retrospective chart review.
Setting: Research hospital: National Institutes of Health (NIH) Clinical Center.
Patients: Volunteers who underwent research protocol endoscopies with large numbers of biopsies during 2001 to 2008 at the NIH.
Main Outcome Measurements: Charts were reviewed for the occurrence of procedure-related major/minor complications.
Results: A total of 253 research endoscopies were performed on 133 patients: 169 colonoscopies, 64 sigmoidoscopies, and 20 upper endoscopies. A total of 9,661 biopsy specimens were obtained for research and histopathologic examination (mean 38.2 +/- 15.6 per procedure). No major complications were identified. Minor complications occurred with 13 (5.1%) lower endoscopic procedures and included self-limited bleeding (4), pain (5), or both (4). There was no statistically significant association between the number of biopsies, type of procedure, location of research biopsies, operator, polypectomy, or the use of nonsteroidal anti-inflammatory drugs and the risk of complications.
Limitations: Retrospective design, modest sample size.
Conclusions: This is the first report on the safety of performing large numbers of endoscopic biopsies in research subjects. This practice is well tolerated and appears to have no more than minimal risk Without appreciably increasing the risk of otherwise routine endoscopy (Gastrointest Endosc 2009;69:906-10.)
C1 [Yao, Michael D.; Groden, Catherine; Mannon, Peter J.] NIAID, Mucosal Immun Sect, Host Def Lab, NIH, Bethesda, MD 20892 USA.
[Yao, Michael D.; von Rosenvinge, Erik C.] NIDDK, NIH, Bethesda, MD USA.
[Yao, Michael D.; von Rosenvinge, Erik C.] Univ Maryland, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21201 USA.
RP Yao, MD (reprint author), NIAID, Mucosal Immun Sect, Host Def Lab, NIH, 10 Ctr Dr,Bldg 10,Room 6-3742, Bethesda, MD 20892 USA.
EM yaomic@mail.nih.gov
FU Intramural NIH HHS [ZIA AI000903-08]
NR 19
TC 13
Z9 13
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD APR
PY 2009
VL 69
IS 4
BP 906
EP 910
DI 10.1016/j.gie.2008.05.015
PG 5
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 425FV
UT WOS:000264623300023
PM 19136110
ER
PT J
AU Boyles, AL
Wilcox, AJ
Taylor, JA
Shi, M
Weinberg, CR
Meye, K
Fredriksen, A
Ueland, PM
Johansen, AMW
Drevon, CA
Jugessur, A
Trung, TN
Gjessing, HK
Vollset, SE
Murray, JC
Christensens, K
Lie, RT
AF Boyles, Abee L.
Wilcox, Allen J.
Taylor, Jack A.
Shi, Min
Weinberg, Clarice R.
Meye, Klaus
Fredriksen, Ase
Ueland, Per Magne
Johansen, Anne Marte W.
Drevon, Christian A.
Jugessur, Astanand
Trung, Truc Nguyen
Gjessing, Hakon K.
Vollset, Stein Emil
Murray, Jeffrey C.
Christensens, Kaare
Lie, Rolv T.
TI Oral Facial Clefts and Gene Polymorphisms in Metabolism of
Folate/One-Carbon and Vitamin A: A Pathway-Wide Association Study
SO GENETIC EPIDEMIOLOGY
LA English
DT Article
DE cleft lip; cleft palate; dietary supplements; folic acid; genetics;
metabolism; vitamin A
ID GLUTAMATE-CARBOXYPEPTIDASE-II; GROWTH-FACTOR-ALPHA; CASE-PARENT TRIADS;
OROFACIAL CLEFTS; RETINOIC ACID; MULTIVITAMIN USE; RISK-FACTORS; PALATE;
LIP; POPULATION
AB An increased risk of facial clefts has been observed among mothers with lower intake of folic acid or vitamin A around conception. We hypothesized that the risk of clefts may be further moderated by genes involved in metabolizing folate or vitamin A. We included 425 case-parent triads in which the child had either cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO), and no other major defects. We analyzed 108 SNPs and one insertion in 29 genes involved in folate/one-carbon metabolism and 68 SNPs from 16 genes involved in vitamin A metabolism. Using the Triad Multi-Marker (TRIMM) approach we performed SNP, gene, chromosomal region, and pathway-Mde association tests of child or maternal genetic effects for both CL/P and CPO. We stratified these analyses on maternal intake of folic acid or vitamin A during the periconceptional period.
As expected with this high number of statistical tests, there were many associations with P-values<0.05; although there were fewer than predicted by chance alone. The strongest association in our data (between fetal FOLH1 and CPO, P = 0.0008) is not in agreement with epidemiologic evidence that folic acid reduces the risk of CL/P in these data, not CPO. Despite strong evidence for genetic causes of oral facial clefts and the protective effects of maternal vitamins, we found no convincing indication that polymorphisms in these vitamin metabolism genes play an etiologic role. Genet. Epidemiol. 33:247-255, 2009. (C) 2008 Wiley Liss, Inc.
C1 [Boyles, Abee L.; Wilcox, Allen J.; Taylor, Jack A.] NIEHS, Epidemiol Branch, NIH, Durham, NC 27709 USA.
[Shi, Min; Weinberg, Clarice R.] NIEHS, Biostat Branch, NIH, Durham, NC 27709 USA.
[Meye, Klaus; Fredriksen, Ase; Ueland, Per Magne] Univ Bergen, Dept Pharmacol, Bergen, Norway.
[Johansen, Anne Marte W.; Drevon, Christian A.] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
[Jugessur, Astanand] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
[Trung, Truc Nguyen; Gjessing, Hakon K.; Vollset, Stein Emil; Lie, Rolv T.] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
[Murray, Jeffrey C.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
[Christensens, Kaare] Univ So Denmark, Epidemiol Unit, Ctr Prevent Congenital Malformat, Odense, Denmark.
RP Boyles, AL (reprint author), NIEHS, Epidemiol Branch, NIH, Mail Drop A3-05,POB 12233, Durham, NC 27709 USA.
EM boylesa@niehs.nih.gov
RI Drevon, Christian /F-6012-2010; Gjessing, Hakon/A-5871-2012; Ueland,
Per/C-7340-2013;
OI Boyles, Abee/0000-0002-8711-2077; Wilcox, Allen/0000-0002-3376-1311;
taylor, jack/0000-0001-5303-6398
FU National Institutes of Health [DE085592, RO1 DE-11948-04, N01-HG-65403,
P50 DE-16215, R37 DE-0559]; National Institute of Environmental Health
Sciences [Z01 ES049027-11, Z01 ES040007]; Research Council of Norway
[166026/V50]; Foundation to promote research into functional vitamin
B12-deficiency; Freia Foundation; Throne-Holst Foundation; Faculty of
Medicine, University of Oslo
FX Contract grant sponsor: National Institutes of Health; Contract grant
number: DE085592, RO1 DE-11948-04, N01-HG-65403, P50 DE-16215, R37
DE-0559; Contract grant sponsor: National Institute of Environmental
Health Sciences; Contract grant number: Z01 ES049027-11, Z01 ES040007;
Contract grant sponsor: the Research Council of Norway; Contract grant
number: 166026/V50; Contract grant sponsor: Foundation to promote
research into functional vitamin B12-deficiency; Contract grant sponsor:
the Freia Foundation; Contract grant sponsor: the Throne-Holst
Foundation; Contract grant sponsor: Faculty of Medicine, University of
Oslo.
NR 44
TC 28
Z9 29
U1 0
U2 6
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0741-0395
J9 GENET EPIDEMIOL
JI Genet. Epidemiol.
PD APR
PY 2009
VL 33
IS 3
BP 247
EP 255
DI 10.1002/gepi.20376
PG 9
WC Genetics & Heredity; Mathematical & Computational Biology
SC Genetics & Heredity; Mathematical & Computational Biology
GA 426DZ
UT WOS:000264689500007
PM 19048631
ER
PT J
AU Summers, K
Roney, KE
da Silva, J
Capraro, G
Cuthbertson, BJ
Kazianis, S
Rosenthal, GG
Ryan, MJ
McConnell, TJ
AF Summers, Kyle
Roney, Kelly E.
da Silva, Jack
Capraro, Gerald
Cuthbertson, Brandon J.
Kazianis, Steven
Rosenthal, Gil G.
Ryan, Michael J.
McConnell, Thomas J.
TI Divergent patterns of selection on the DAB and DXB MHC class II loci in
Xiphophorus fishes
SO GENETICA
LA English
DT Article
DE Swordtail fish; Major histocompatibility complex; Positive selection;
Non-classical MHC II locus
ID MAJOR HISTOCOMPATIBILITY COMPLEX; BALANCING SELECTION;
NATURAL-SELECTION; GENE FAMILY; HLA-DM; POLYMORPHISM; RECOMBINATION;
MOLECULES; LIKELIHOOD; DIVERSIFICATION
AB Two MHC class II loci, DAB (a classical class II locus) and DXB (putatively a non-classical class II locus), were sequenced in samples of individuals from two populations of swordtail fish, Xiphophorus multilineatus and X. pygmaeus. The DAB locus showed higher levels of genetic variation in the B1-encoding region, (putative binding region) than the DXB locus. We used two methods to investigate d(N)/d(S) ratios. The results from a maximum likelihood method based on phylogenetic relationships indicated positive selection on the B1 region of DAB (this method could not be used on DXB). Results from a coalescent-based method also showed evidence for positive selection in the B1 region of DAB, but only weak evidence for selection on the DXB. Further analyses indicated that recombination is an important source of variation in the B1 region of DAB, but has a relatively small effect on DXB. Overall, our results were consistent with the hypothesis that the DAB locus is under positive selection driven by antagonistic coevolution, and that the DXB locus plays the role of a non-classical MHC II locus. We also used simulations to investigate the presence of an elevated synonymous substitution rate in the binding region. The simulations revealed that the elevated rate could be caused by an interaction between positive selection and codon bias.
C1 [Summers, Kyle; McConnell, Thomas J.] E Carolina Univ, Dept Biol, Greenville, NC 27858 USA.
[Roney, Kelly E.] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA.
[da Silva, Jack] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia.
[Capraro, Gerald] Wake Forest Univ, Bowman Gray Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27103 USA.
[Cuthbertson, Brandon J.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Kazianis, Steven] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA.
[Rosenthal, Gil G.] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA.
[Ryan, Michael J.] Univ Texas Austin, Sect Integrat Biol, Austin, TX 78712 USA.
RP Summers, K (reprint author), E Carolina Univ, Dept Biol, Greenville, NC 27858 USA.
EM summersk@ecu.edu
RI da Silva, Jack/H-1266-2014; Rosenthal, Gil/E-6924-2015;
OI da Silva, Jack/0000-0001-5631-5421; Rosenthal, Gil/0000-0003-0342-9024;
McConnell, Thomas/0000-0003-3176-4938
FU NSF [MCB 0110541]
FX This research was supported by NSF grant # MCB 0110541 to Thomas
McConnell. We thank Felix Breden and four anonymous reviewers for
comments on the manuscript. This paper is dedicated to the memory of
Steven Kazianis.
NR 58
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Z9 6
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0016-6707
J9 GENETICA
JI Genetica
PD APR
PY 2009
VL 135
IS 3
BP 379
EP 390
DI 10.1007/s10709-008-9284-4
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 413ZO
UT WOS:000263833900013
PM 18600302
ER
PT J
AU Schmidt-Kuntzel, A
Nelson, G
David, VA
Schaffer, AA
Eizirik, E
Roelke, ME
Kehler, JS
Hannah, SS
O'Brien, SJ
Menotti-Raymond, M
AF Schmidt-Kuentzel, Anne
Nelson, George
David, Victor A.
Schaeffer, Alejandro A.
Eizirik, Eduardo
Roelke, Melody E.
Kehler, James S.
Hannah, Steven S.
O'Brien, Stephen J.
Menotti-Raymond, Marilyn
TI A Domestic cat X Chromosome Linkage Map and the Sex-Linked orange Locus:
Mapping of orange, Multiple Origins and Epistasis Over nonagouti
SO GENETICS
LA English
DT Article
ID FELIS-CATUS; COAT COLOR; RADIATION HYBRID; MC1R MUTATIONS; MSH RECEPTOR;
GENETIC-MAP; GENOME; MICROSATELLITES; TYROSINASE; DELETION
AB A comprehensive genetic linkage map of the domestic cat X chromosome was generated with the goal of localizing the genomic position of the classic X-linked orange (O) locus. Microsatellite markers with ail average spacing of 3 Mb were selected front sequence traces of the cat 1.9X whole genome sequence (WGS), including the pseudoautosomal region 1 (PAR1). Extreme variation in recombination rates (centimorgans per megabase) was observed along the X chromosome, ranging from a virtual absence of recombination events in a region estimated to be >30 Mb to recombination frequencies of 15.7 cM/Mb in a segment estimated to be <0.3 Mb. This detailed linkage map was applied to position the X-linked orange gene, placing this locus on the q arm of the X chromosome, as opposed to a previously reported location on the p arm. Fine mapping placed the locus between markers at positions 106 and 116.8 Mb in the Current 1.9X-coverage sequence assembly of the cat genome. Haplotype analysis revealed potential recombination events that could reduce the size of the candidate region to 3.5 Mb and suggested Multiple Origins for the orange phenotype in the domestic cat. Furthermore, epistasis of orange over nonagouti was demonstrated at the genetic level.
C1 [Schmidt-Kuentzel, Anne; Nelson, George; Roelke, Melody E.] NCI, Lab Genom Divers, Sci Applicat Int Corp, Frederick, MD 21702 USA.
[Schmidt-Kuentzel, Anne] George Washington Univ, Dept Genet, Washington, DC 20037 USA.
[Schaeffer, Alejandro A.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
[Schaeffer, Alejandro A.] NIH, Dept Hlth & Human Serv, Bethesda, MD 20894 USA.
[Eizirik, Eduardo] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, BR-900 Porto Alegre, RS, Brazil.
[Eizirik, Eduardo] Inst Procarnivoros, BR-12945010 Atibaia, Brazil.
[Hannah, Steven S.] Nestle Purina PetCare, St Louis, MO 63102 USA.
RP Schmidt-Kuntzel, A (reprint author), NCI, Lab Genom Divers, Sci Applicat Int Corp, Bldg 560,Room 11-38, Frederick, MD 21702 USA.
EM anne.c.sk@gmail.com
RI Schaffer, Alejandro/F-2902-2012; Eizirik, Eduardo/K-8034-2012
OI Eizirik, Eduardo/0000-0002-9658-0999
FU National Cancer Institute, National Institutes of Health (NIH)
[NO1-CO-12400]; National Library of Medicine
FX We thank Gregory Barsh for discussion and sharing of unpublished
results, Ana Carolina Garcia Escobar for the collection and extraction
(if the DNAs obtained from Brazil, the Laboratory of Genomic Diversity
core lab for the extraction of the local samples, Joan Pontius and the
Advanced Biomedical Computing Center for their advice regarding the
whole genome sequencing of the cat, Carlos Driscoll for his suggestion
of using microsatellites for haplotype analysis, Solveig Pflueger for
her advice as a cat breeding specialist, Richa Agarwala and James Tomlin
for assistance with map computation, and John Fyfe (Michigan State
University) for making available to this study samples from a feline
spinal muscular atrophy pedigree that also segregated for orange. We
also acknowledge the photographers Who generated the images used in
Figure 1A: Susan Feingold (Fulton County Animal Services), Joanna Harkin
(Alliance for Stray Animals and People), Bill Hopkins (pet owner),
Andrea Thompson (pet owner), Anthony Griffith (author of Introduction to
Genetic Analysis), and Martin Feather and Cristy Bird (feral
tortoiseshell cat living on the grounds of a wat in Bangkok, Thailand).
We also thank Marti Welch (Scientific Publication, Graphics and Media;
Advanced Technology Program, Science Applications International
Corporation, Frederick, MD) for excellent assistance in generating
figures and photographs. This publication has been funded in whole or in
part with federal funds from the National Cancer Institute, National
Institutes of Health (NIH), under contract no. NO1-CO-12400. The content
of this publication does not necessarily reflect the views or policies
of the Department of Health and Human Services, nor does mention of
trade names, commercial products, or organizations imply endorsement by
the U.S. Government. This research is supported in part by, the
Intramural Research Program of the NIH, National Library of Medicine.
NR 62
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U1 0
U2 17
PU GENETICS SOC AM
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 0016-6731
J9 GENETICS
JI Genetics
PD APR
PY 2009
VL 181
IS 4
BP 1411
EP 1425
DI 10.1534/genetics.108.095240
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 499IW
UT WOS:000270213700021
PM 19189955
ER
PT J
AU Gray, MM
Granka, JM
Bustamante, CD
Sutter, NB
Boyko, AR
Zhu, L
Ostrander, EA
Wayne, R
AF Gray, Melissa M.
Granka, Julie M.
Bustamante, Carlos D.
Sutter, Nathan B.
Boyko, Adam R.
Zhu, Lan
Ostrander, Elaine A.
Wayne, Robert
TI Linkage Disequilibrium and Demographic History of Wild and Domestic
Canids
SO GENETICS
LA English
DT Article
ID MITOCHONDRIAL-DNA; HUMAN GENOME; NUCLEOTIDE POLYMORPHISM;
NATURAL-POPULATIONS; DOG GENOME; HAPLOTYPE RECONSTRUCTION; CONSERVATION
GENETICS; ASCERTAINMENT BIAS; ISLE-ROYALE; GREY WOLVES
AB Assessing the extent of linkage disequilibrium (LD) in natural populations of a nonmodel species has been difficult due to the lack of available genomic markers. However, with advances in genotyping and genome sequencing, genomic characterization of natural populations has become feasible. Using sequence data and SNP genotypes, we measured LD and modeled the demographic history of wild canid populations and domestic dog breeds. In I I gray Wolf Populations and one Coyote Population, we find that the extent of LD as measured by the distance at which r(2) = 0.2 extends <10 kb in outbred populations to >1.7 Mb in populations that have experienced significant founder events and bottlenecks. This large range in the extent of LD parallels that observed in 18 dog breeds where the r(2) value varies from similar to 20 kb to >5 Mb. Furthermore, in modeling demographic history under a composite-likelihood framework, we find that two of five wild canid populations exhibit evidence of a historical population contraction. Five domestic dog breeds display evidence for a minor population contraction during domestication and a more severe contraction during breed formation. Only a 5% reduction in nucleotide diversity was observed as a result of domestication, whereas the loss of nucleotide diversity with breed formation averaged 35%.
C1 [Gray, Melissa M.; Wayne, Robert] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90032 USA.
[Granka, Julie M.; Bustamante, Carlos D.; Boyko, Adam R.] Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14853 USA.
[Sutter, Nathan B.] Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA.
[Zhu, Lan] Oklahoma State Univ, Dept Stat, Stillwater, OK 74078 USA.
[Ostrander, Elaine A.] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
RP Gray, MM (reprint author), Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, 621 Charles E Young Dr S, Los Angeles, CA 90032 USA.
EM mgray9@ucla.edu
RI Gray, Melissa/B-5025-2008;
OI Gray, Melissa/0000-0002-1756-5468; Ostrander, Elaine/0000-0001-6075-9738
FU National Institutes of Health (NIH) [5 T32 HG002536, 5 U01 HL084706-02];
National Science Foundation [0516310, 0733033]; National Human Genome
Research Institute
FX We thank the following individuals for their helpful comments and
discussion: three anonymous reviewers, Matthew Stephens, joint Novembre,
Olaf Thalmann, Klaus Koepfli, Pascal Quignon, Bridgett vonHoldt, and
John Pollinger. We also thank Dan Stailler, Seth Riley, Eli Geffen,
Kevin Chase, Gordon Lark, and countless dog owners and breeders for
sample contribution. For analytical assistance, we thank Katarzyna Bryc,
Badri Padhukasahasram, and Ryan Hernandez. This Study was supported by
National Institutes of Health (NIH) training grant 5 T32 HG002536
(M.M.G.), by National Science Foundation grants 0516310 (C.D.B.) and
0733033 (R.K.W.), by NIH grant 5 U01 HL084706-02 (A.R.B.), and by the
Intramural Program of the National Human Genome Research Institute
(N.B.S.).
NR 77
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U1 3
U2 43
PU GENETICS SOC AM
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 1943-2631
J9 GENETICS
JI Genetics
PD APR
PY 2009
VL 181
IS 4
BP 1493
EP 1505
DI 10.1534/genetics.108.098830
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 499IW
UT WOS:000270213700027
PM 19189949
ER
PT J
AU Bonham, VL
Sellers, SL
Gallagher, TH
Frank, D
Odunlami, AO
Price, EG
Cooper, LA
AF Bonham, Vence L.
Sellers, Sherrill L.
Gallagher, Thomas H.
Frank, Danielle
Odunlami, Adebola O.
Price, Eboni G.
Cooper, Lisa A.
TI Physicians' attitudes toward race, genetics, and clinical medicine
SO GENETICS IN MEDICINE
LA English
DT Article
DE clinical decision making; race; genetic variation; health disparities;
physicians' attitudes
ID PRIMARY-CARE PHYSICIANS; HEALTH DISPARITIES; HEART-FAILURE;
BIOMEDICAL-RESEARCH; AFRICAN-AMERICAN; BLACK PATIENTS; GENOMICS;
ASSOCIATION; ETHNICITY; CANCER
AB Purpose: This qualitative study explored black and white general internists' attitudes about the relevance of race in clinical care; views of the relationships among race, genetics, and disease; and expectations about the future of genetics and health. Methods: We conducted 10 racially concordant focus groups of primary care physicians in five metropolitan areas in the United States. Ninety board certified or eligible general internists (50 self-identified whites and 40 self-identified blacks) participated in the study, Analysis included a two-stage independent review and adjudication process. Results: Both black and white physicians concluded that the race of the patient is medically relevant but did not agree upon why race is important in clinical decisions. They were reticent to make connections among race, genetics, and disease and asserted that genetics has a limited role in explaining racial differences in health. However, they were enthusiastic about the future of genomic medicine, believing that the main benefit will be the potential to improve the efficacy of commonly used drugs. Conclusions: Understanding the similarities and differences between black and white physicians' attitudes and beliefs about race, health and genetics is important for the translation of genomics to clinical care. Genet Med 2009:11(4): 279-286.
C1 [Bonham, Vence L.; Odunlami, Adebola O.] NHGRI, Social & Behav Res Branch, NIH, Bethesda, MD 20892 USA.
[Sellers, Sherrill L.] Univ Wisconsin, Sch Social Work, Madison, WI 53706 USA.
[Sellers, Sherrill L.] Miami Univ, Dept Family Studies & Social Work, Oxford, OH 45056 USA.
[Gallagher, Thomas H.] Univ Washington, Dept Med, Div Gen Internal Med, Seattle, WA USA.
[Gallagher, Thomas H.] Univ Washington, Dept Med Hist & Eth, Seattle, WA 98195 USA.
[Frank, Danielle] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA.
[Price, Eboni G.] Tulane Univ, Hlth Sci Ctr, Sect Gen Internal Med & Geriatr, New Orleans, LA 70118 USA.
[Cooper, Lisa A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA.
RP Bonham, VL (reprint author), NHGRI, Social & Behav Res Branch, NIH, 31 Ctr Dr Room B1B55, Bethesda, MD 20892 USA.
EM bonhamv@mail.nih.gov
OI Price-Haywood, Eboni/0000-0003-2901-3852
FU National Human Genome Research Institute, National Institutes of Health
FX The study was Supported (in part) by the Intramural Research Program of
the National Human Genome Research Institute, National Institutes of
Health. The authors thank Elizabeth M. Phillips and Sarah Knerr for
their research assistance and Alan M. Guttmacher, MD, and Francis S.
Collins, MD, PhD, (National Human Genome Research Institute) for their
suggestions in preparing an early draft of this article.
NR 40
TC 10
Z9 10
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD APR
PY 2009
VL 11
IS 4
BP 279
EP 286
DI 10.1097/GIM.0b013e318195aaf4
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 435KT
UT WOS:000265343500007
PM 19265721
ER
PT J
AU Kim, JH
Ebersole, T
Kouprina, N
Noskov, VN
Ohzeki, JI
Masumoto, H
Mravinac, B
Sullivan, BA
Pavlicek, A
Dovat, S
Pack, SD
Kwon, YW
Flanagan, PT
Loukinov, D
Lobanenkov, V
Larionov, V
AF Kim, Jung-Hyun
Ebersole, Thomas
Kouprina, Natalay
Noskov, Vladimir N.
Ohzeki, Jun-Ichirou
Masumoto, Hiroshi
Mravinac, Brankica
Sullivan, Beth A.
Pavlicek, Adam
Dovat, Sinisa
Pack, Svetlana D.
Kwon, Yoo-Wook
Flanagan, Patrick T.
Loukinov, Dmitri
Lobanenkov, Victor
Larionov, Vladimir
TI Human gamma-satellite DNA maintains open chromatin structure and
protects a transgene from epigenetic silencing
SO GENOME RESEARCH
LA English
DT Article
ID MULTIPLE SEQUENCE ALIGNMENT; HUMAN CENTROMERIC CHROMATIN;
ERYTHROID-CELLS; HUMAN-X; IKAROS; EXPRESSION; INSULATOR; PROTEINS;
FAMILY; HETEROCHROMATIN
AB The role of repetitive DNA sequences in pericentromeric regions with respect to kinetochore/heterochromatin structure and function is poorly understood. Here, we use a mouse erythroleukemia cell (MEL) system for studying how repetitive DNA assumes or is assembled into different chromatin structures. We show that human gamma-satellite DNA arrays allow a transcriptionally permissive chromatin conformation in an adjacent transgene and efficiently protect it from epigenetic silencing. These arrays contain CTCF and Ikaros binding sites. In MEL cells, this gamma-satellite DNA activity depends on binding of Ikaros proteins involved in differentiation along the hematopoietic pathway. Given our discovery of gamma-satellite DNA in pericentromeric regions of most human chromosomes and a dynamic chromatin state of gamma-satellite arrays in their natural location, we suggest that gamma-satellite DNA represents a unique region of the functional centromere with a possible role in preventing heterochromatin spreading beyond the pericentromeric region.
C1 [Kim, Jung-Hyun; Ebersole, Thomas; Kouprina, Natalay; Noskov, Vladimir N.; Ohzeki, Jun-Ichirou; Masumoto, Hiroshi; Larionov, Vladimir] NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA.
[Mravinac, Brankica; Sullivan, Beth A.] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA.
[Pavlicek, Adam] La Jolla Labs, San Diego, CA 92121 USA.
[Dovat, Sinisa] Univ Wisconsin, Dept Pediat, Madison, WI USA.
[Pack, Svetlana D.; Kwon, Yoo-Wook; Flanagan, Patrick T.; Loukinov, Dmitri; Lobanenkov, Victor] NIAID, Immunol Lab, Bethesda, MD 20815 USA.
RP Larionov, V (reprint author), NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA.
EM larionov@mail.nih.gov
RI Pack, Svetlana/C-2020-2014;
OI Lobanenkov, Victor/0000-0001-6665-3635; Sullivan,
Beth/0000-0001-5216-4603
FU NIH; National Cancer Institute, Center for Cancer Research
FX We thank Eric Bouhassira for providing the RL5 and RL4 cell lines, Rolf
Sprengel for the pBlue. iCRE plasmid, and Gary Felsenfeld for HS4
insulator plasmids. We thank Megumi Nakano for fruitful discussions and
help with some experiments. This research was supported by the
intramural research program of the NIH, National Cancer Institute,
Center for Cancer Research.
NR 37
TC 34
Z9 38
U1 0
U2 2
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI WOODBURY
PA 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2924 USA
SN 1088-9051
J9 GENOME RES
JI Genome Res.
PD APR
PY 2009
VL 19
IS 4
BP 533
EP 544
DI 10.1101/gr.086496.108
PG 12
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
GA 427LX
UT WOS:000264781900002
PM 19141594
ER
PT J
AU Davis, BW
Raudsepp, T
Wilkerson, AJP
Agarwala, R
Schaffer, AA
Houck, M
Chowdhary, BP
Murphy, WJ
AF Davis, Brian W.
Raudsepp, Terje
Pearks Wilkerson, Alison J.
Agarwala, Richa
Schaeffer, Alejandro A.
Houck, Marlys
Chowdhary, Bhanu P.
Murphy, William J.
TI A high-resolution cat radiation hybrid and integrated FISH mapping
resource for phylogenomic studies across Felidae
SO GENOMICS
LA English
DT Article
DE Domestic cat; Radiation hybrid map; Comparative mapping; FISH mapping;
Synteny; Chromosome rearrangement; Felidae
ID MAMMALIAN CHROMOSOME EVOLUTION; DOMESTIC CAT; GENOME; MAP; MUTATION;
TYROSINASE; PATTERNS; SEQUENCE; CANIDAE; DOG
AB We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low marker density on feline autosomes and the X chromosome, in addition to regions flanking interspecies chromosomal breakpoints. Average gap (breakpoint) size between cat-human ordered conserved segments is less than 900 kb. The map was used for a fine-scale comparison of conserved syntenic blocks with the human and canine genomes. Corroborative fluorescence in situ hybridization (FISH) data were generated using 129 domestic cat BAC clones as probes, providing independent confirmation of the long-range correctness of the map. Cross-species hybridization of BAC probes on divergent felids from the genera Profelis (serval) and Panthera (snow leopard) provides further evidence for karyotypic conservation within felids, and demonstrates the utility of such probes for future studies of chromosome evolution within the cat family and in related carnivores. The integrated map constitutes a comprehensive framework for identifying genes controlling feline phenotypes of interest, and to aid in assembly of a higher coverage feline genome sequence. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Davis, Brian W.; Raudsepp, Terje; Pearks Wilkerson, Alison J.; Chowdhary, Bhanu P.; Murphy, William J.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.
[Agarwala, Richa] NIH, IEB, NCBI, Natl Lib Med,Dept Hlth & Human Serv, Bethesda, MD 20894 USA.
[Schaeffer, Alejandro A.] NIH, CBB, NCBI, Natl Lib Med,Dept Hlth & Human Serv, Bethesda, MD 20894 USA.
[Houck, Marlys] San Diego Zoo Conservat Res, Escondido, CA 92025 USA.
RP Murphy, WJ (reprint author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, Mail Stop 4458, College Stn, TX 77843 USA.
EM wmurphy@cvm.tamu.edu
RI Schaffer, Alejandro/F-2902-2012
FU Morris Animal Foundation [D06FE-063]; Winn Feline Foundation [06026];
NIH; NLM
FX We thank Keith Durkin, Julie Fronczek, Jan Janecka, William Nash, and
Ashley Seabury for helpful advice and technical support. We thank
Cynthia King for the serval blood sample. Jim Mullikin provided a list
of candidate contigs for primer design. Marilyn Menotti-Raymond shared
the marker positions on a new genetic map computed by AAS. This work was
supported by funds from the Morris Animal Foundation (Grant D06FE-063)
to WJM and the Winn Feline Foundation (Grant 06026) to WJM, TR, and BPC.
This research was supported in part by the intramural research program
of the NIH, NLM (RA, AAS).
NR 32
TC 25
Z9 25
U1 1
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0888-7543
J9 GENOMICS
JI Genomics
PD APR
PY 2009
VL 93
IS 4
BP 299
EP 304
DI 10.1016/j.ygeno.2008.09.010
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 431HC
UT WOS:000265051200002
PM 18951970
ER
PT J
AU Menotti-Raymond, M
David, VA
Schaffer, AA
Tomlin, JF
Eizirik, E
Phillip, C
Wells, D
Pontius, JU
Hannah, SS
O'Brien, SJ
AF Menotti-Raymond, Marilyn
David, Victor A.
Schaeffer, Alejandro A.
Tomlin, James F.
Eizirik, Eduardo
Phillip, Cornel
Wells, David
Pontius, Joan U.
Hannah, Steven S.
O'Brien, Stephen J.
TI An autosomal genetic linkage map of the domestic cat, Felis silvestris
catus
SO GENOMICS
LA English
DT Article
DE Domestic cat; Genetic linkage map; STRs; Microsatellites
ID RADIATION HYBRID MAP; GENOME; MICROSATELLITES; MOUSE; TYROSINASE;
MUTATIONS; PHENOTYPE; EVOLUTION; DELETION
AB We report on the completion of an autosomal genetic linkage (GL) map of the domestic cat (Felis silvestris catus). Unlike two previous linkage maps of the cat constructed with a hybrid pedigree between the domestic cat and the Asian leopard cat, this map was generated entirely with domestic cats, using a large multigenerational pedigree (n=256) maintained by the Nestle Purina PetCare Company. Four hundred eighty-three simple tandem repeat (STR) loci have been assigned to linkage groups on the cat's 18 autosomes. A single linkage group spans each autosome. The length of the cat map, estimated at 4370 cM, is long relative to most reported mammalian maps. A high degree of concordance in marker order was observed between the third-generation map and the 1.5 Mb-resolution radiation hybrid (RH) map of the cat. Using the cat 1.9x whole-genome sequence, we identified map coordinates for 85% of the loci in the cat assembly, with high concordance observed in marker order between the linkage map and the cat sequence assembly. The present version represents a marked improvement over previous cat linkage maps as it (i) nearly doubles the number of markers that were present in the second-generation linkage map in the cat, (ii) provides a linkage map generated in a domestic cat pedigree which will more accurately reflect recombination distances than previous maps generated in a hybrid pedigree, and (iii) provides single linkage groups spanning each autosome. Marker order was largely consistent between this and the previous maps, though the use of a hybrid pedigree in the earlier versions appears to have contributed to some suppression of recombination. The improved linkage map will provide an added resource for the mapping of phenotypic variation in the domestic cat and the use of this species as a model system for biological research. Published by Elsevier Inc.
C1 [Menotti-Raymond, Marilyn; David, Victor A.; Phillip, Cornel; Wells, David; O'Brien, Stephen J.] NCI, Lab Genom Divers, Frederick, MD 21702 USA.
[Schaeffer, Alejandro A.] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
[Tomlin, James F.] NIH, Computat Biosci & Engn Lab, Ctr Informat Technol, Bethesda, MD 20894 USA.
[Eizirik, Eduardo] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Ctr Biol Genom & Mol, BR-90619900 Porto Alegre, RS, Brazil.
[Pontius, Joan U.] NCI, SAIC Frederick Inc, Lab Genom Divers, Frederick, MD 21702 USA.
[Hannah, Steven S.] Nestle Purina PetCare Co, St Louis, MO 63134 USA.
RP Menotti-Raymond, M (reprint author), NCI, Lab Genom Divers, Frederick, MD 21702 USA.
EM raymond@ncifcrf.gov
RI Schaffer, Alejandro/F-2902-2012; Eizirik, Eduardo/K-8034-2012
OI Eizirik, Eduardo/0000-0002-9658-0999
FU National Institutes of Health [N01-CO-12400]; NLM; CIT; National Cancer
Institute
FX We thank Richa Agarwala (National Center for Biotechnology Information,
National Institutes of Health, Bethesda, MD) for her assistance in
setting up the map construction computations. We also thank William J.
Murphy (College of Veterinary Medicine and Biomedical Sciences, Texas A
and M University) for providing the latest RH maps in the cat and for
exchange which has facilitated coordination of the GLand RH maps. We
additionally thank Guo Kui Pei, (Laboratory of Genomic Diversity,
SAIC-Frederick, Inc.), for technical assistance in generating genotypes
and Tammy Schroyer (Scientific Publication, Graphics and Media; Advanced
Technology Program, SAIC-Frederick, Inc.) for generation of excellent
technical drawings of the cat maps. This research was supported in part
by the Intramural Research Program of the National Institutes of Health,
NCI, NLM, CIT. This project has been funded in whole or in part with
federal funds from the National Cancer Institute, National Institutes of
Health, under contract N01-CO-12400. The content of this publication
does not necessarily reflect the views or policies of the Department of
Health and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the U.S. Government.
NR 42
TC 26
Z9 26
U1 1
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0888-7543
J9 GENOMICS
JI Genomics
PD APR
PY 2009
VL 93
IS 4
BP 305
EP 313
DI 10.1016/j.ygeno.2008.11.004
PG 9
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 431HC
UT WOS:000265051200003
PM 19059333
ER
PT J
AU McHale, CM
Zhang, LP
Lan, Q
Li, GL
Hubbard, AE
Forrest, MS
Vermeulen, R
Chen, J
Shen, M
Rappaport, SM
Yin, SN
Smith, MT
Rothman, N
AF McHale, Cliona M.
Zhang, Luoping
Lan, Qing
Li, Guilan
Hubbard, Alan E.
Forrest, Matthew S.
Vermeulen, Roel
Chen, Jinsong
Shen, Min
Rappaport, Stephen M.
Yin, Songnian
Smith, Martyn T.
Rothman, Nathaniel
TI Changes in the peripheral blood transcriptome associated with
occupational benzene exposure identified by cross-comparison on two
microarray platforms
SO GENOMICS
LA English
DT Article
DE Benzene exposure; Gene expression; Human blood; Toxicogenomics
ID STRAND BREAK REPAIR; HEMATOPOIETIC PROGENITOR CELLS; GENE-EXPRESSION;
BONE-MARROW; DNA-DAMAGE; CHROMOSOMAL TRANSLOCATIONS; INDUCED
HEMATOTOXICITY; LIPID-METABOLISM; CXC-CHEMOKINES; APOPTOSIS
AB Benzene is an established cause of leukemia, and possibly lymphoma, in humans, but the underlying molecular pathways remain largely undetermined. We used two microarray platforms to identify global gene expression changes associated with well-characterized occupational benzene exposure in the peripheral blood mononuclear cells (PBMC) of a population of shoe-factory workers. Differential expression of 2692 genes (Affymetrix) and 1828 genes (Illumina) was found and the concordance was 50% (based on an average fold-change >= 1.3 from the two platforms), with similar expression ratios among the concordant genes. Four genes (CXCL16, ZNF331, JUN and PF4), which we previously identified by microarray and confirmed by real-time PCR, were among the top 100 genes identified by both platforms in the current study. Gene ontology analysis showed overrepresentation of genes involved in apoptosis among the concordant genes while pathway analysis identified pathways related to lipid metabolism. The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified. (C) 2009 Elsevier Inc. All rights reserved.
C1 [McHale, Cliona M.; Zhang, Luoping; Hubbard, Alan E.; Forrest, Matthew S.; Chen, Jinsong; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Lan, Qing; Shen, Min; Rothman, Nathaniel] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
[Li, Guilan; Yin, Songnian] Inst Occupat Hlth & Poison Control, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
[Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
[Rappaport, Stephen M.] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
RP McHale, CM (reprint author), Univ Calif Berkeley, Sch Publ Hlth, 211 Hildebrand Hall, Berkeley, CA 94720 USA.
EM cmchale@berkeley.edu
RI Chen, Jinsong/A-1374-2009; Vermeulen, Roel/F-8037-2011;
OI Vermeulen, Roel/0000-0003-4082-8163; Forrest,
Matthew/0000-0002-2141-0303
FU NIH [RO1ES06721, P42ES04705]; National Institute of Environmental Health
Sciences [P42ES05948, P30ES10126]; National Cancer Institute
FX We thank the participants for taking part in this study. Supported by
NIH grants RO1ES06721 and P42ES04705 (to Martyn T. Smith), and
P42ES05948 and P30ES10126 (to Stephen M. Rappaport) from the National
Institute of Environmental Health Sciences and Intramural Funds from the
National Cancer Institute.
NR 52
TC 31
Z9 35
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0888-7543
J9 GENOMICS
JI Genomics
PD APR
PY 2009
VL 93
IS 4
BP 343
EP 349
DI 10.1016/j.ygeno.2008.12.006
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 431HC
UT WOS:000265051200007
PM 19162166
ER
PT J
AU Byrnes, KR
Stoica, B
Loane, DJ
Riccio, A
Davis, MI
Faden, AI
AF Byrnes, Kimberly R.
Stoica, Bogdan
Loane, David J.
Riccio, Angela
Davis, Margaret I.
Faden, Alan I.
TI Metabotropic Glutamate Receptor 5 Activation Inhibits Microglial
Associated Inflammation and Neurotoxicity
SO GLIA
LA English
DT Article
DE metabotropic glutamate receptor; neurotoxic; nitric oxide; ROS; signal
transduction
ID NECROSIS-FACTOR-ALPHA; TRAUMATIC NEURONAL INJURY; SPINAL-CORD-INJURY;
CELL-DEATH; NITRIC-OXIDE; BRAIN-INJURY; GROUP-I; NEUROPROTECTIVE
ACTIVITY; DEPENDENT MECHANISM; FUNCTIONAL RECOVERY
AB The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been reported in microglia and may affect their activation. However, the expression and role of mGluR5 in microglia is unclear. Using immunocytochemistry and Western blot, we demonstrate that mGluR5 protein is expressed in primary microglial cultures. Activation of mGluR5 using the selective agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) significantly reduces microglial activation in response to lipopolysaccharide, as indicated by a reduction in nitric oxide, reactive oxygen species, and TNF alpha production. Microglial induced neurotoxicity is also markedly reduced by CHPG treatment. The anti-inflammatory effects of CHPG are not observed in microglial cultures from mGluR5 knockout mice and are blocked by selective mGluR5 antagonists, suggesting that these actions are mediated by the mGluR5 receptor. Anti-inflammatory actions of mGluR5 activation are attenuated by phospholipase C and protein kinase C inhibitors, as well as by calcium chelators, suggesting that the mGluR5 activation in microglia involves the G(alpha q)-protein signal transduction pathway. These data indicate that microglial mGluR5 may represent a novel target for modulating neuroinflammation, an important component of both acute and chronic neurodegenerative disorders. (C) 2008 Wiley-Liss, Inc.
C1 [Byrnes, Kimberly R.; Stoica, Bogdan; Loane, David J.; Riccio, Angela; Faden, Alan I.] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20057 USA.
[Davis, Margaret I.] NIAAA, NIH, Rockville, MD 20852 USA.
RP Byrnes, KR (reprint author), Georgetown Univ, Med Ctr, Dept Neurosci, Room EP12A,New Res Bldg,3970 Reservoir Rd NW, Washington, DC 20057 USA.
EM krb27@georgetown.edu
RI Davis, Margaret/F-4165-2010; STOICA, BOGDAN/H-9782-2013;
OI STOICA, BOGDAN/0000-0002-2501-6434; Davis, Margaret/0000-0002-0489-8351;
Byrnes, Kimberly/0000-0002-7501-7734
FU NINDS NIH HHS [5R01 NS 037313-08, R01 NS037313, R01 NS037313-08]
NR 53
TC 65
Z9 66
U1 1
U2 2
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0894-1491
J9 GLIA
JI Glia
PD APR 1
PY 2009
VL 57
IS 5
BP 550
EP 560
DI 10.1002/glia.20783
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 416NE
UT WOS:000264012000008
PM 18816644
ER
PT J
AU Tian, E
Ten Hagen, KG
AF Tian, E.
Ten Hagen, Kelly G.
TI Recent insights into the biological roles of mucin-type O-glycosylation
SO GLYCOCONJUGATE JOURNAL
LA English
DT Article; Proceedings Paper
CT EMBO Workshop 2007
CY DEC, 2007
CL Lille, FRANCE
DE Glycosylation; O-glycosylation; Development; Mucin; Disease
ID POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; ALPHA-D-GALACTOSAMINE;
FAMILIAL TUMORAL CALCINOSIS; HYPEROSTOSIS-HYPERPHOSPHATEMIA SYNDROME;
GLYCAN BRANCH FORMATION; UDP-GALNAC TRANSFERASE; IGA NEPHROPATHY;
MOLECULAR-CLONING; CORE 2; DROSOPHILA-MELANOGASTER
AB In this special issue of the Glycoconjugate Journal focusing on glycosciences and development, we summarize recent advances in our understanding of the role of mucin-type O-glycans in development and disease. The presence of this widespread protein modification has been known for decades, yet identification of its biological functions has been hampered by the redundancy and complexity of the enzyme family controlling the initiation of O-glycosylation, as well as the diversity of extensions of the core sugar. Recent studies in organisms as diverse as mammals and Drosophila have yielded insights into the function of this highly abundant and evolutionarily-conserved protein modification. Gaining an understanding of mucin-type O-glycans in these diverse systems will elucidate crucial conserved processes underlying many aspects of development and homeostasis.
C1 [Tian, E.; Ten Hagen, Kelly G.] NIDCR, Dev Glycobiol Unit, NIH, Bethesda, MD 20892 USA.
RP Ten Hagen, KG (reprint author), NIDCR, Dev Glycobiol Unit, NIH, Bldg 30,Room 426,30 Convent Dr,MSC 4370, Bethesda, MD 20892 USA.
EM Kelly.Tenhagen@nih.gov
FU Intramural NIH HHS [Z01 DE000713-03]
NR 98
TC 99
Z9 101
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0282-0080
J9 GLYCOCONJUGATE J
JI Glycoconjugate J.
PD APR
PY 2009
VL 26
IS 3
BP 325
EP 334
DI 10.1007/s10719-008-9162-4
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 418XF
UT WOS:000264182500009
PM 18695988
ER
PT J
AU Berrigan, D
Potischman, N
Dodd, KW
Hursting, SD
Lavigne, J
Barrett, JC
Ballard-Barbash, R
AF Berrigan, David
Potischman, Nancy
Dodd, Kevin W.
Hursting, Stephen D.
Lavigne, Jackie
Barrett, J. Carl
Ballard-Barbash, Rachel
TI Race/ethnic variation in serum levels of IGF-I and IGFBP-3 in US adults
SO GROWTH HORMONE & IGF RESEARCH
LA English
DT Article
DE Cancer; Insulin-like growth factor; Race/ethnicity; Age
ID GROWTH-FACTOR-I; FACTOR-BINDING PROTEIN-3; FACTOR BINDING-PROTEIN-3
CONCENTRATIONS; LIFE-STYLE FACTORS; BREAST-CANCER RISK; MIDDLE-AGED MEN;
PREMENOPAUSAL WOMEN; FACTOR (IGF)-I; PLASMA-LEVELS; P53-DEFICIENT MICE
AB Objective: The IGF axis plays a significant role in normal growth and development and variation in IGFs is associated with health outcomes. Past studies report variation in IGF levels among race/ethnic groups known to differ in disease incidence. This paper reports on race/ethnic variation in serum levels of IGF-I and IGF-BP3 in a nationally representative and ethnically diverse sample of US adults.
Design: Serum IGF-I and IGFBP-3 levels from the fasting subsamples (n = 6061) of respondents to the US National Health and Nutrition Examination Surgery III (NHANES III) were analyzed using an IGF-I ELISA (Diagnostic Systems Laboratory (DSL 10-5600) and an IGFBP-3 IRMA (DSN 6600). The NHANES is a combined examination and interview survery of a nationally representative sample of US adults. Regression analyses were used to estmiate cross-sectional associations between the IGF axis and demographic variables.
Results: In unadjusted analysis, serum IGF-I levels were higher in males than in females, and IGFBP-3 levels were higher in females than in males. Both analytes were lower in older adults. Univariate analyses indicate that serum levels of IGF-I are lower in female Non-Hispanic Whites (NHW) (256 [4,9]) and Hispanies (249 [6.6]) than in Non-Hispanic Blacks (NHB) (281 [4.9]). However, in males, IGF levels in NHWs (287 [3.6]) and NHBs (284 [4.3]) are similar and levels in Mexican Americans are only moderately reduced (265 [3.4]). Notably, NHB's have the highest molar ratio of IGF-I:IGFBP-3 at all ages. After adjustment for age and BMI, gender and race/ethnicity differences persist.
Conclusions: These cross-sectional data support exploration of the IGF axis as an explanation for some race/ethnic differences in cancer incidence. Published by Elsevier Ltd.
C1 [Berrigan, David; Potischman, Nancy; Hursting, Stephen D.; Lavigne, Jackie; Barrett, J. Carl; Ballard-Barbash, Rachel] NCI, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Dodd, Kevin W.] NCI, Biometry Res Grp, Canc Prevent Div, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Hursting, Stephen D.] Univ Texas Austin, Dept Nutr, Austin, TX 78712 USA.
[Barrett, J. Carl] Novartis Inst Biomed Res Inc, Cambridge, MA USA.
RP Berrigan, D (reprint author), NCI, Appl Res Program, Div Canc Control & Populat Sci, Execut Plaza N MSC 7344,Room 4095B, Bethesda, MD 20892 USA.
EM berrigad@mail.nih.gov
FU Cancer Prevention Fellowship Program
FX We thank Viraj Patel For her tireless work analyzing these samples and
Lisa Kahle for programming support. David Berrigan acknowledges the
Cancer Prevention Fellowship Program for support during the early
portions of this project, Geraldine McQuillan of NCHS for facilitating
our use of the NHANES III surplus serum. and Michael Nicar for advice
about laboratory analyses. Tanya Agur-Collins, Anne Rodgers, and two
anonymous reviewers provided useful comments on the MS.
NR 64
TC 24
Z9 25
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1096-6374
J9 GROWTH HORM IGF RES
JI Growth Horm. IGF Res.
PD APR
PY 2009
VL 19
IS 2
BP 146
EP 155
DI 10.1016/j.ghir.2008.08.005
PG 10
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA 430KX
UT WOS:000264989100008
PM 18812263
ER
PT J
AU Freedman, N
Derakhshan, MH
Abnet, CC
Schatzkin, A
Hollenbeck, AR
McColl, KEL
AF Freedman, N.
Derakhshan, M. H.
Abnet, C. C.
Schatzkin, A.
Hollenbeck, A. R.
McColl, K. E. L.
TI MALE PREDOMINANCE OF UPPER GASTROINTESTINAL ADENOCARCINOMA CANNOT BE
EXPLAINED BY DIFFERENCES IN TOBACCO SMOKING IN MEN VERSUS WOMEN
SO GUT
LA English
DT Meeting Abstract
CT Annual Meeting of the British-Society-of-Gastroenterology
CY MAR 23-26, 2009
CL Glasgow, SCOTLAND
SP British Soc Gastroenterol
C1 [Freedman, N.; Abnet, C. C.; Schatzkin, A.; Hollenbeck, A. R.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
[Derakhshan, M. H.; McColl, K. E. L.] Univ Glasgow, Div Med Sci, Glasgow, Lanark, Scotland.
RI Derakhshan, Mohammad/K-8694-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
J9 GUT
JI Gut
PD APR
PY 2009
VL 58
SU 1
BP A32
EP A33
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 422QR
UT WOS:000264443300084
ER
PT J
AU Barrett, AJ
Sloand, E
AF Barrett, A. John
Sloand, Elaine
TI Autoimmune mechanisms in the pathophysiology of myelodysplastic
syndromes and their clinical relevance
SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
LA English
DT Editorial Material
ID SYNDROME MDS; ANTITHYMOCYTE GLOBULIN; CHRONIC INFLAMMATION;
ULCERATIVE-COLITIS; CD34 CELLS; PROFILES; THERAPY
C1 [Barrett, A. John] NHLBI, Hematol Branch, Stem Cell Allotransplantat Sect, NIH, Bethesda, MD 20892 USA.
RP Barrett, AJ (reprint author), NHLBI, Hematol Branch, Stem Cell Allotransplantat Sect, NIH, Bethesda, MD 20892 USA.
EM barrettj@nhlbi.nih.gov
NR 18
TC 36
Z9 38
U1 0
U2 2
PU FERRATA STORTI FOUNDATION
PI PAVIA
PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY
SN 0390-6078
J9 HAEMATOL-HEMATOL J
JI Haematol-Hematol. J.
PD APR
PY 2009
VL 94
IS 4
BP 449
EP 451
DI 10.3324/haematol.2009.006080
PG 3
WC Hematology
SC Hematology
GA 430YX
UT WOS:000265029600002
PM 19336747
ER
PT J
AU Rimsza, LM
Chan, WC
Gascoyne, RD
Campo, E
Jaffe, ES
Staudt, LM
Delabie, J
Rosenwald, A
Murphy, SP
AF Rimsza, Lisa M.
Chan, Wing C.
Gascoyne, Randy D.
Campo, Elias
Jaffe, Elaine S.
Staudt, Louis M.
Delabie, Jan
Rosenwald, Andreas
Murphy, Shawn P.
TI CIITA or RFX coding region loss of function mutations occur rarely in
diffuse large B-cell lymphoma cases and cell lines with low levels of
major histocompatibility complex class II expression
SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
LA English
DT Letter
ID TRANSACTIVATOR; SURVIVAL
C1 [Rimsza, Lisa M.] Univ Arizona, Dept Pathol, Tucson, AZ 85724 USA.
[Chan, Wing C.] Univ Nebraska, Dept Pathol, Omaha, NE 68182 USA.
[Gascoyne, Randy D.] British Columbia Canc Agcy, Dept Pathol, Vancouver, BC V5Z 4E6, Canada.
[Campo, Elias] Univ Barcelona, Dept Pathol, Barcelona, Spain.
[Jaffe, Elaine S.; Staudt, Louis M.] NCI, Metab Branch, Bethesda, MD 20892 USA.
[Delabie, Jan] Radium Hosp, Dept Pathol, Oslo, Norway.
[Rosenwald, Andreas] Univ Wurzburg, Dept Pathol, D-8700 Wurzburg, Germany.
[Murphy, Shawn P.] Univ Rochester, Sch Med & Dent, Dept Obstet & Gynecol, Rochester, NY 14642 USA.
[Murphy, Shawn P.] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA.
RP Rimsza, LM (reprint author), Univ Arizona, Dept Pathol, 1501 N Campbell Ave,Box 245043, Tucson, AZ 85724 USA.
EM lrimsza@email.arizona.edu
OI Delabie, Jan/0000-0001-5023-0689; Campo, elias/0000-0001-9850-9793
FU PHS HHS [RSG0605501L1B]
NR 9
TC 14
Z9 14
U1 0
U2 0
PU FERRATA STORTI FOUNDATION
PI PAVIA
PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY
SN 0390-6078
J9 HAEMATOL-HEMATOL J
JI Haematol-Hematol. J.
PD APR
PY 2009
VL 94
IS 4
BP 596
EP 598
DI 10.3324/haematol.2008.000752
PG 3
WC Hematology
SC Hematology
GA 430YX
UT WOS:000265029600024
PM 19229048
ER
PT J
AU Alter, BP
Giri, N
Savage, SA
Rosenberg, PS
AF Alter, B. P.
Giri, N.
Savage, S. A.
Rosenberg, P. S.
TI CANCER IN INHERITED BONE MARROW FAILURE SYNDROMES
SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
LA English
DT Meeting Abstract
CT 5th International Congress of the
European-Working-Group-on-Myelodysplastic-Syndromes-and-Bone-Marrow-Fail
ures
CY APR 22-24, 2009
CL Rotterdam, NETHERLANDS
SP European Working Grp Myelodysplatic Syndromes & Bone Marrow Failures
C1 [Alter, B. P.; Giri, N.; Savage, S. A.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Rosenberg, P. S.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
RI Savage, Sharon/B-9747-2015
OI Savage, Sharon/0000-0001-6006-0740
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FERRATA STORTI FOUNDATION
PI PAVIA
PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY
SN 0390-6078
J9 HAEMATOL-HEMATOL J
JI Haematol-Hematol. J.
PD APR
PY 2009
VL 94
BP S7
EP S7
PG 1
WC Hematology
SC Hematology
GA 443LN
UT WOS:000265911600022
ER
PT J
AU Young, NS
AF Young, N. S.
TI TREATMENT OF APLASTIC ANEMIA: IMPACT OF MOLECULAR PATHOGENESIS
SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
LA English
DT Meeting Abstract
CT 5th International Congress of the
European-Working-Group-on-Myelodysplastic-Syndromes-and-Bone-Marrow-Fail
ures
CY APR 22-24, 2009
CL Rotterdam, NETHERLANDS
SP European Working Grp Myelodysplatic Syndromes & Bone Marrow Failures
C1 [Young, N. S.] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FERRATA STORTI FOUNDATION
PI PAVIA
PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY
SN 0390-6078
J9 HAEMATOL-HEMATOL J
JI Haematol-Hematol. J.
PD APR
PY 2009
VL 94
BP S6
EP S6
PG 1
WC Hematology
SC Hematology
GA 443LN
UT WOS:000265911600020
ER
PT J
AU Blanck, HM
Yaroch, AL
Atienza, AA
Ms, SLY
Zhang, J
Masse, LC
AF Blanck, Heidi M.
Yaroch, Amy L.
Atienza, Audie A.
Ms, Sarah L. Yi
Zhang, Jian
Masse, Louise C.
TI Factors Influencing Lunchtime Food Choices Among Working Americans
SO HEALTH EDUCATION & BEHAVIOR
LA English
DT Article
DE fast-food restaurant; food choice; nutrition; work site
ID HEALTH-PROMOTION PROGRAMS; DIETARY CHANGE; WELL TRIAL; OBESITY; WOMEN;
CONSUMPTION; NUTRITION; PATTERNS; HABITS; ADULTS
AB There is growing interest in the usefulness of the workplace as a site for promotion of healthful food choices. The authors therefore analyzed data of U. S. adults (N = 1,918) who reported working outside the home and eating lunch. The majority (84.0%) of workers had a break room. About one half (54.0%) purchased lunch = 2 times/week, with higher percentages for males, Blacks, younger (age 18-34 years) versus older adults (age 55 years or older), and obese versus normal-weight persons. The most important lunch food choice value was convenience (34.3%), followed by taste (27.8%), cost (20.8%), and health (17.1%). The typical source for purchasing lunch was a fast-food restaurant (43.4%), followed by on-site cafeteria/snack shop (25.3%), full-service restaurant (16.9%), supermarket (5.2%), vending machine (4.4%), and convenience store (4.0%); younger adults and those less educated relied more on fast-food places. This study identifies individual factors and values that may influence future dietary health initiatives in the work site.
C1 [Blanck, Heidi M.; Zhang, Jian] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Yaroch, Amy L.; Atienza, Audie A.; Masse, Louise C.] NCI, Bethesda, MD 20892 USA.
[Ms, Sarah L. Yi] Emory Univ, Atlanta, GA 30322 USA.
RP Blanck, HM (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS K-26, Atlanta, GA 30341 USA.
EM hblanck@cdc.gov
NR 29
TC 31
Z9 31
U1 4
U2 27
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1090-1981
J9 HEALTH EDUC BEHAV
JI Health Educ. Behav.
PD APR
PY 2009
VL 36
IS 2
BP 289
EP 301
DI 10.1177/1090198107303308
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 428UM
UT WOS:000264876500006
PM 17602103
ER
PT J
AU Savage, SA
Alter, BP
AF Savage, Sharon A.
Alter, Blanche P.
TI Dyskeratosis Congenital
SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Dyskeratosis congenita; Telomere; DKC1; TERC; TERT; TINF2; Bone marrow
failure
ID BONE-MARROW FAILURE; TELOMERASE REVERSE-TRANSCRIPTASE;
HOYERAAL-HREIDARSSON-SYNDROME; STEM-CELL TRANSPLANTATION; IDIOPATHIC
PULMONARY-FIBROSIS; COLONY-STIMULATING FACTOR; IN-SITU HYBRIDIZATION;
APLASTIC-ANEMIA; PROGRESSIVE PANCYTOPENIA; GENETIC-HETEROGENEITY
AB Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized clinically by the triad of abnormal nails, reticular skin pigmentation, and oral leukoplakia, and is associated with high risk of developing aplastic anemia, myelodysplastic syndrome, leukemia, and solid tumors. Patients have very short germline telomeres, and approximately half have mutations in one of six genes encoding proteins that maintain telomere function. Accurate diagnosis of DC is critical to ensure proper clinical management, because patients who have DC and bone marrow failure do not respond to immunosuppressive therapy and may have increased morbidity and mortality associated with hematopoietic stem cell transplantation.
C1 [Savage, Sharon A.; Alter, Blanche P.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20852 USA.
RP Savage, SA (reprint author), NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd, Rockville, MD 20852 USA.
EM savagesh@mail.nih.gov
RI Savage, Sharon/B-9747-2015
OI Savage, Sharon/0000-0001-6006-0740
FU National Institutes of Health; National Cancer Institute; Division of
Cancer Epidemiology and Genetics
FX This work was supported by the intramural research program of the
National Institutes of Health, National Cancer Institute, Division of
Cancer Epidemiology and Genetics.
NR 69
TC 77
Z9 82
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8588
J9 HEMATOL ONCOL CLIN N
JI Hematol. Oncol. Clin. North Am.
PD APR
PY 2009
VL 23
IS 2
BP 215
EP +
DI 10.1016/j.hoc.2009.01.003
PG 18
WC Oncology; Hematology
SC Oncology; Hematology
GA 435UY
UT WOS:000265370000005
PM 19327580
ER
PT J
AU Sloand, EM
AF Sloand, Elaine M.
TI Hypocellular Myelodysplasia
SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Myelodysplasia; Cellularity; Hypoplastic; Immune-mediated
ID COLONY-STIMULATING-FACTOR; TUMOR-NECROSIS-FACTOR; ACUTE
MYELOID-LEUKEMIA; RABBIT ANTITHYMOCYTE GLOBULIN; RESIDUAL DISEASE
DETECTION; ACQUIRED APLASTIC-ANEMIA; CYCLOSPORINE-A THERAPY; BONE-MARROW
BIOPSIES; IMMUNOSUPPRESSIVE THERAPY; LOW-RISK
AB Myelodysplasia must be considered in the differential diagnosis of patients who have bone marrow failure, but bone marrow cellularity per se may not substantially affect either response to therapy or prognosis. It is unclear whether the primary pathophysiologic defect differs between hyper- and hypoplastic patients who have myelodysplasia. Cellularity does not seem to affect response to immunosuppressive therapy significantly and does not seem to be the major factor affecting improvements in response to lenalidomide, stem cell transplantation, or hematopoietic growth factors.
C1 NHLBI, Hematol Branch, Bethesda, MD 20892 USA.
RP Sloand, EM (reprint author), NHLBI, Hematol Branch, 10 Ctr Dr,Bldg10,CRC Rm 4E5230, Bethesda, MD 20892 USA.
EM sloande@nih.gov
NR 90
TC 9
Z9 10
U1 1
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8588
EI 1558-1977
J9 HEMATOL ONCOL CLIN N
JI Hematol. Oncol. Clin. North Am.
PD APR
PY 2009
VL 23
IS 2
BP 347
EP +
DI 10.1016/j.hoc.2009.01.015
PG 15
WC Oncology; Hematology
SC Oncology; Hematology
GA 435UY
UT WOS:000265370000013
PM 19327588
ER
PT J
AU Ghany, MG
Strader, DB
Thomas, DL
Seeff, LB
AF Ghany, Marc G.
Strader, Doris B.
Thomas, David L.
Seeff, Leonard B.
TI Diagnosis, Management, and Treatment of Hepatitis C: An Update
SO HEPATOLOGY
LA English
DT Review
ID HUMAN-IMMUNODEFICIENCY-VIRUS; SUSTAINED VIROLOGICAL RESPONSE;
INTERFERON-ALPHA-2B PLUS RIBAVIRIN; ALANINE AMINOTRANSFERASE LEVELS;
LIVER-TRANSPLANT RECIPIENTS; STAGE RENAL-DISEASE; HIV-INFECTED PATIENTS;
INJECTION-DRUG USERS; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE
C1 [Seeff, Leonard B.] NIDDKD, Liver Dis Res Branch, NIH, Bethesda, MD 20892 USA.
[Ghany, Marc G.] NIDDKD, Liver Dis Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Strader, Doris B.] Univ Vermont, Coll Med, Div Gastroenterol Hepatol Fletcher, Burlington, VT USA.
[Thomas, David L.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
RP Seeff, LB (reprint author), NIDDKD, Liver Dis Res Branch, NIH, Bldg 31,Room 9A27, Bethesda, MD 20892 USA.
EM seffl@extra.niddk.nih.gov
OI Ling, Simon/0000-0002-4223-4601
NR 420
TC 1869
Z9 1966
U1 33
U2 137
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD APR
PY 2009
VL 49
IS 4
BP 1335
EP 1374
DI 10.1002/hep.22759
PG 40
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 428PV
UT WOS:000264862100031
PM 19330875
ER
PT J
AU Kanaoka, Y
AF Kanaoka, Yuichi
TI A Life Dedicated to Chemistry in Nature Preface
SO HETEROCYCLES
LA English
DT Biographical-Item
C1 [Kanaoka, Yuichi] Hokkaido Univ, Sapporo, Hokkaido 060, Japan.
[Kanaoka, Yuichi] NIH, Bethesda, MD 20892 USA.
[Kanaoka, Yuichi] Toyama Coll, Toyama, Japan.
[Kanaoka, Yuichi] Toyama Univ Int Studies, Toyama, Japan.
[Kanaoka, Yuichi] Toyama Int Inst, Toyama, Japan.
RP Kanaoka, Y (reprint author), Hokkaido Univ, Sapporo, Hokkaido 060, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 1
EP 2
DI 10.3987/COM-08-S(D)Preface-1
PG 2
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200001
ER
PT J
AU Jacobson, KA
Kirk, KL
AF Jacobson, Kenneth A.
Kirk, Kenneth L.
TI John W. Daly - An Appreciation
SO HETEROCYCLES
LA English
DT Biographical-Item
AB John W. Daly was engaged in groundbreaking basic research for nearly 50 years at NIH in Bethesda, Maryland. A primary focus of his research included the discovery, structure elucidation, synthesis and pharmacology of alkaloids and other biologically active natural products. However, he earned further acclaim in other areas that included the investigation of the structure-activity relationships for agonists/antagonists at adenosine, adrenergic, histamine, serotonin, and acetylcholine receptors. In addition he was a pioneer in studies of the modulation and functional relationships for systems involving calcium, cyclic nucleotides, ion channels and phospholipids and in the mechanism of actions of caffeine and other xanthines.
C1 [Jacobson, Kenneth A.; Kirk, Kenneth L.] NIDDK, Mol Recognit Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Jacobson, KA (reprint author), NIDDK, Mol Recognit Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
EM kajacobs@helix.nih.gov
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU Intramural NIH HHS [ZIA DK031117-22]
NR 0
TC 0
Z9 0
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 61
EP 71
DI 10.3987/COM-08-S(D)Memoire-1
PG 11
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200003
PM 26160996
ER
PT J
AU Fredholm, BB
Jacobson, KA
AF Fredholm, Bertil B.
Jacobson, Kenneth A.
TI Adenosine Receptors: The Contributions by John W. Daly
SO HETEROCYCLES
LA English
DT Biographical-Item
AB John Daly played an important role in defining adenosine receptors as an important target for drug discovery. His systematic work characterized the effects of adenosine analogues on cyclic AMP in the brain that were antagonized by methylxanthines. He also played a decisive role in establishing these receptors as bona fide biochemical entities and contributed to the discovery of receptor heterogeneity. This brief review will cover some of his important early discoveries in the pharmacology and medicinal chemistry of adenosine receptors.
C1 [Fredholm, Bertil B.] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
[Jacobson, Kenneth A.] NIDDK, Mol Recognit Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
RP Fredholm, BB (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM Bertil.Fredholm@fyfa.ki.se
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU Intramural NIH HHS [Z99 DK999999, ZIA DK031117-22]
NR 0
TC 6
Z9 6
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 73
EP 83
DI 10.3987/COM-08-S(D)Memoire-2
PG 11
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200004
PM 26113768
ER
PT J
AU Kirk, KL
Gusovsky, F
AF Kirk, Kenneth L.
Gusovsky, Fabian
TI John W. Daly: The Early Years. The NIH Shift and Cyclic-AMP Assays:
Early Pharmacological Breakthroughs
SO HETEROCYCLES
LA English
DT Biographical-Item
AB Although trained as an organic chemist, John Daly embarked in his early years at NIH on several research projects that involved a significant and sophisticated application of biochemistry and pharmacology. He was able to work with impressive leaders in these fields, including the late Nobel Laureate, Julius Axelrod. In this report, we highlight two aspects of this work-his involvement in the discovery of the NIH shift and the development of a method to quickly assay cyclic AMP biosynthesis. The strong pharmacological component of his research career evolved from these and other early seminal discoveries.
C1 [Kirk, Kenneth L.] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
[Gusovsky, Fabian] Eisai Res Inst, Andover, MA 01810 USA.
RP Kirk, KL (reprint author), NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
EM kennethk@bdg8.niddk.nih.gov; fabian_gusovsky@eri.eisai.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 85
EP 93
DI 10.3987/COM-08-S(D)Memoire-3
PG 9
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200005
ER
PT J
AU Andriamaharavo, NR
AF Andriamaharavo, Nirina R.
TI The John Daly I Knew in Madagascar: November 1989-December 1993 January
1994-December 1998-February 2003
SO HETEROCYCLES
LA English
DT Biographical-Item
C1 NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
RP Andriamaharavo, NR (reprint author), NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
EM andriamaharavor@niddk.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 95
EP 98
DI 10.3987/COM-08-S(D)Memoire-4
PG 4
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200006
ER
PT J
AU Garraffo, HM
Spande, TF
AF Garraffo, H. Martin
Spande, Thomas F.
TI DISCOVERY OF BATRACHOTOXIN: THE LAUNCH OF THE FROG ALKALOID PROGRAM AT
NIH
SO HETEROCYCLES
LA English
DT Review
DE Dart-Poison Frog; Alkaloid; X-Ray Crystallography; NMR Spectram; Mass
Spectrometry
ID ARROW POISON FROG; PHYLLOBATES-AUROTAENIA; PASSERINE BIRDS; DART FROGS;
DENDROBATIDAE; CONFIGURATION; BICOLOR; VENOM
AB The determination of the structures of the batrachotoxins (BTXs), extremely toxic steroidal alkaloids found in the skins of the dart-poison frogs of the genus Phyllobates from Colombia in the 1960s is reviewed. The BTXs function by locking open sodium-ion channels of nerve and muscle, thereby depolarizing them. The structures and pharmacology of the BTXs were determined by a team led by John W. Daly. This research started a 40 year long study of alkaloids from frog skin, whereby John and his team identified and/or characterized more than 800 such alkaloids. The source of the BTXs, not synthesized but sequestered from diet by the frogs, is briefly discussed, in the context of the occurrence of BTXs in birds of Papua New Guinea and in a small melyrid beetle found there. Emphasized is the critical importance of maintaining and safe-guarding the large collection of frog-skin extracts and data accumulated since.
C1 [Garraffo, H. Martin; Spande, Thomas F.] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
RP Garraffo, HM (reprint author), NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
EM garraffo@helix.nih.gov
NR 28
TC 7
Z9 7
U1 6
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 195
EP 205
DI 10.3987/REV-08-SR(D)6
PG 11
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200011
ER
PT J
AU Garraffo, HM
Spande, TF
Williams, M
AF Garraffo, H. Martin
Spande, Thomas F.
Williams, Michael
TI EPIBATIDINE: FROM FROG ALKALOID TO ANALGESIC CLINICAL CANDIDATES. A
TESTIMONIAL TO "TRUE GRIT"!
SO HETEROCYCLES
LA English
DT Review
DE Poison Frog; Alkaloid; Epibatidine; Nicotinic Agonist; Straub-Tail
ID NICOTINIC ACETYLCHOLINE-RECEPTORS; DRUG DISCOVERY; AMPHIBIAN SKIN;
POISON FROG; IN-VITRO; LIGAND; AGONIST; POTENT; (+)-EPIBATIDINE;
(-)-EPIBATIDINE
AB A routine toxicity test of the alkaloid extract from the Ecuadoran poison frog Epipedobates anthonyi gave a Straub-tail (S-T) response on sub-cutaneous (sc) injection in mice, a phenomenon never seen before from any poison frog alkaloid. It is characteristic of opioids; however, in this instance it was not blocked by a morphine-antagonist, naloxone. Its site of action was soon shown to be a nicotinic receptor. The determination of the structure of this novel analgesic named epibatidine has led to a renaissance of research into controlling pain via nicotinic pathways (thereby minimizing the risk of tolerance/addiction) and the synthesis of many analogs, some of which are discussed.
C1 [Garraffo, H. Martin; Spande, Thomas F.] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
[Williams, Michael] Cephalon Inc, Discovery Res, W Chester, PA USA.
RP Garraffo, HM (reprint author), NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
NR 35
TC 19
Z9 19
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 207
EP 217
DI 10.3987/REV-08-SR(D)5
PG 11
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200012
ER
PT J
AU Saporito, RA
Spande, TF
Garraffo, HM
Donnelly, MA
AF Saporito, Ralph A.
Spande, Thomas F.
Garraffo, H. Martin
Donnelly, Maureen A.
TI ARTHROPOD ALKALOIDS IN POISON FROGS: A REVIEW OF THE 'DIETARY
HYPOTHESIS'
SO HETEROCYCLES
LA English
DT Review
DE Alkaloid; Frog; Arthropod; Biosynthesis; Sequestration
ID SKIN ALKALOIDS; DENDROBATID FROGS; VENOM ALKALOIDS; AMPHIBIAN SKIN;
PUMILIOTOXINS; ANT; BIOSYNTHESIS; DECAHYDROQUINOLINES; BATRACHOTOXIN;
CHEMISTRY
AB Poison frogs are chemically defended from predators and/or microorganisms by the presence of alkaloids in dermal skin glands. Over the past 40 years, more than 800 alkaloids, which are generally organized into 28 structural classes, have been identified in several lineages of poison frogs worldwide. Originally, the presence of alkaloids in frogs was thought to be the result of biosynthesis, however research led largely by John W. Daly resulted in the discovery that most of these alkaloids are sequestered unchanged from dietary arthropods. In the present paper, we review the most significant findings and studies that led to the proposal of the 'dietary hypothesis'.
C1 [Saporito, Ralph A.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA.
[Spande, Thomas F.; Garraffo, H. Martin] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
[Donnelly, Maureen A.] Florida Int Univ, Coll Arts & Sci, Miami, FL 33199 USA.
RP Saporito, RA (reprint author), Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA.
EM ralph.saporito@gmail.com
FU NSF
FX We would like to thank Charles W. Myers, AMNH, Curator Emeritus, for
sharing recollections and his perspective. We thank Nirina Rabe
Andriamaharavo and many other chemists over the years for their
assistance in the analysis of alkaloids. Among the latter is Tappey H.
Jones (Virginia Military Institute of Lexington, VA) who for decades
collaborated with Daly in the identification and synthesis of ant
alkaloids and whose work provided much of the basis for our earliest
formulations of the 'dietary hypothesis'. We would also like to thank
Richard L. Hoffman (Virginia Museum of Natural History), John T. Longino
(Evergreen State College), and Roy A. Norton (State University of New
York, Syracuse) for their assistance in identifying many of the
alkaloid-containing arthropods. Special thanks to Henry M. Fales and
Jenise M. Snyder for reviewing this manuscript and providing, valuable
comments. An NSF postdoctoral fellowship supported R.A.S.
NR 61
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U1 3
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
EI 1881-0942
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 277
EP 297
DI 10.3987/REV-08-SR(D)11
PG 21
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200017
ER
PT J
AU Wang, CB
Widom, J
Petronijevic, F
Burnett, JC
Nuss, JE
Bavari, S
Gussio, R
Wipf, P
AF Wang, Chenbo
Widom, Julia
Petronijevic, Filip
Burnett, James C.
Nuss, Jonathan E.
Bavari, Sina
Gussio, Rick
Wipf, Peter
TI SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS OF BOTULINUM
NEUROTOXIN METALLOPROTEASE
SO HETEROCYCLES
LA English
DT Article
DE NSC 240898; BoNT Serotype A Metalloprotease; Sonogashira Coupling;
Gold-Catalyzed Indole Formation; Diaryl Ether
ID SMALL-MOLECULE INHIBITORS; LIGHT-CHAIN; SEROTYPE-A; TOXIN; DERIVATIVES;
MANAGEMENT; ARYL
AB Based on the lead therapeutic agent NSC 240898, a new series of heterocyclic inhibitors of the BoNT serotype A metalloprotease has been generated. Highlights of the synthetic sequences include Sonogashira couplings of polysubstituted building blocks and gold-catalyzed indole formations. Preliminary structure-activity relationship studies afford detailed insights into the steric and electrostatic properties of the pharmacophore of this molecular scaffold.
C1 [Wang, Chenbo; Widom, Julia; Petronijevic, Filip; Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA.
[Burnett, James C.] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA.
[Nuss, Jonathan E.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Gussio, Rick] NCI, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA.
RP Wang, CB (reprint author), Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA.
FU National Cancer Institute; National Institutes of Health [N01-CO-12400];
Department of Defense [W81XWH-06-02-0027]
FX This project has been funded in whole or in part with federal funds from
the National Cancer Institute, National Institutes of Health, under
contract N01-CO-12400. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the U.S. Government.
This research was supported [in part] by the Developmental Therapeutics
Program in the Division of Cancer Treatment and Diagnosis of the
National Cancer Institute. This research was also funded from the
Department of Defense, grant W81XWH-06-02-0027. The authors thank Ms.
Jennie Kravchenko for the preparation of the tetrazole analogue of NSC
240898.26
NR 26
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U1 0
U2 6
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PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 487
EP 520
DI 10.3987/COM-08-S(D)8
PG 34
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200042
ER
PT J
AU Zhou, DJ
Toyooka, N
Nemoto, H
Yamaguchi, K
Tsuneki, H
Wada, T
Sasaoka, T
Sakai, H
Tezuka, Y
Kadota, S
Jones, TH
Garraffo, HM
Spande, TF
Daly, JW
AF Zhou, Dejun
Toyooka, Naoki
Nemoto, Hideo
Yamaguchi, Kaoru
Tsuneki, Hiroshi
Wada, Tsutomu
Sasaoka, Toshiyasu
Sakai, Hideki
Tezuka, Yasuhiro
Kadota, Shigetoshi
Jones, Tappey H.
Garraffo, H. Martin
Spande, Thomas F.
Daly, John W.
TI SYNTHESIS, DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY, AND
EVALUATIONS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS OF A
HYDROXYINDOLIZIDINE ALKALOID FROM THE ANT MYRMICARIA MELANOGASTER
SO HETEROCYCLES
LA English
DT Article
DE Hydroxyindolizidine Alkaloid; Myrmicaria melanogaster; Neuronal
Nicotinic Acetylcholine Receptor; Martin's Protocol; alpha 4 beta 2
Nicotinic Receptor
ID ENANTIOSELECTIVE SYNTHESIS; QUINOLIZIDINE; INDOLIZIDINE; METATHESIS;
ACID
AB The first chiral synthesis of new hydroxyindolizidine alkaloid (1) detected in the ant Myrmicaria melanogaster has been achieved, and its absolute stereochemistry was determined to be 3S, 5R, 8S, 9S by the present chiral synthesis.
C1 [Zhou, Dejun; Toyooka, Naoki; Nemoto, Hideo; Yamaguchi, Kaoru; Tsuneki, Hiroshi; Wada, Tsutomu; Sasaoka, Toshiyasu; Sakai, Hideki] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
[Tezuka, Yasuhiro; Kadota, Shigetoshi] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan.
[Jones, Tappey H.] Virginia Mil Inst, Dept Chem, Lexington, VA 24450 USA.
[Garraffo, H. Martin; Spande, Thomas F.; Daly, John W.] NIDDKD, Bioorgan Chem Lab, NIH, US Dept HHS, Bethesda, MD 20892 USA.
RP Zhou, DJ (reprint author), Toyama Univ, Grad Sch Med & Pharmaceut Sci, Sugitani 2630, Toyama 9300194, Japan.
NR 18
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U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 565
EP 571
DI 10.3987/COM-08-S(D)16
PG 7
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200046
ER
PT J
AU Fitch, RW
Spande, TF
Garraffo, HM
Chase, RR
Clinedinst, MA
Parkes, DA
Reed, R
Whittaker, NF
Daly, JW
AF Fitch, Richard W.
Spande, Thomas F.
Garraffo, H. Martin
Chase, Rachael R.
Clinedinst, Mylaka A.
Parkes, Derek A.
Reed, Richard
Whittaker, Noel F.
Daly, John W.
TI DIOICINE: A NOVEL PRENYLATED PURINE ALKALOID FROM GYMNOCLADUS DIOICUS
SO HETEROCYCLES
LA English
DT Article
DE NMR Spectrometry; Xanthine; Caffeine; Coffeetree; Guanine
ID MARINE SPONGE; BINDING; RECEPTORS; DRUG; RAT; PHARMACOLOGY; METABOLISM;
CAFFEINE; SUBTYPE
AB The Kentucky coffeetree, Gymnocladus dioicus (L., K. Koch) is a leguminous tree reputed to be toxic to livestock and to contain the toxic nicotinic acetylcholine receptor agonist cytisine. Analysis of extracts of various tree parts by gas chromatography-mass spectrometry failed to reveal the presence of cytisine. Neither [H-3]-epibatidine binding in rat cerebral cortex nor functional fluorescence assays in cultured cells expressing nicotinic receptor subunits indicated significant activity. However, a novel purine alkaloid, 3-((E)-3-methylbuta-1,3-dienyl)-1,7-dimethylisoguanine, which we have named dioicine, was identified as the major lipophilic alkaloid in the methanolic extract from leaves and seeds. Dioicine and its hydrolysis products are likely to be responsible for the historical use of the tree's seeds as a coffee substitute. Herein we describe the isolation, structure elucidation and preliminary biological characterization of dioicine.
C1 [Fitch, Richard W.; Chase, Rachael R.; Clinedinst, Mylaka A.; Parkes, Derek A.; Reed, Richard] Indiana State Univ, Dept Chem, Terre Haute, IN 47809 USA.
[Spande, Thomas F.; Garraffo, H. Martin; Whittaker, Noel F.; Daly, John W.] NIDDKD, Bioorgan Chem Lab, NIH, US Dept HHS, Bethesda, MD 20892 USA.
RP Fitch, RW (reprint author), Indiana State Univ, Dept Chem, 600 Chestnut St, Terre Haute, IN 47809 USA.
FU University Research Committee [UNR246]; National Science Foundation
[CHE0521075]
FX The authors deeply mourn the passing of their friend and colleague, John
Daly. RWF wishes to thank Dr. Marion T. Jackson, Dr. Peter E. Scott and
Mr. Ian MacDonald for advice and assistance with taxonomy, collection,
and preparation of herbarium specimens. Mr. Ryand J. Tucker 2 is also
thanked for assistance with preparation. of samples. A generous gift of
HEK cells expressing various subunit combinations for nicotinic
receptors41,42 by Drs. Kenneth J. Kellar and Yingxian Xiao of
Georgetown University Medical School is appreciated. This work was
performed with funds from Indiana State University including the
Department of Chemistry and College of Arts and Sciences (startup funds
for RWF), Office of the Provost (Promising Scholar Award to RWF), and
Center for Public Service and Community Engagement (Faculty Fellow Award
to RWF, Undergraduate Fellow Award to RRC), University Research
Committee (UNR246), and the Lilly Endowment (CPSCE/Office of the
Provost). A grant from the National Science Foundation (CHE0521075) for
a 400 MHz NMR spectrometer at Indiana State University is also
gratefully acknowledged. Research at NIH was funded by the intramural
program of NIDDK.
NR 47
TC 3
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U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
EI 1881-0942
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 583
EP 598
DI 10.3987/COM-08-S(D)19
PG 16
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200048
ER
PT J
AU Kem, WR
Rocca, J
Garraffo, HM
Spande, TF
Daly, JW
Soti, F
AF Kem, William R.
Rocca, James
Garraffo, H. Martin
Spande, Thomas F.
Daly, John W.
Soti, Ferenc
TI SYNTHESIS AND SPECTROSCOPIC COMPARISON OF THE EIGHT METHYL-2,3
'-BIPYRIDYLS AND IDENTIFICATION OF A HOPLONEMERTINE ALKALOID AS
3-METHYL-2,3 '-BIPYRIDYL
SO HETEROCYCLES
LA English
DT Article
DE Pyridyl Alkaloid; Bipyridyl; Nemertine; Marine Natural Product;
Bipyridyl Synthesis
ID ANABASEINE; ANNOUNCEMENT; ANABASINE; RECEPTORS; ANATABINE; TOBACCO
AB The pyridyl ring is frequently found in natural products and drugs. While bipyridyls have served as useful scaffolds for development of industrial and pesticidal chemicals, their biological properties are still not well understood. Only 2,3'-bipyridyl, of the six isomeric bipyridyls, has been reported as a natural product in tobacco plants and in a hoplonemertine marine worm, Amphiporus angulatus (Aa), which uses its pyridyl alkaloid-rich venom to paralyze its crustacean prey and chemically defend itself against predators. Here we report for the first time the synthesis and spectroscopic properties of all eight possible methyl 2,3'-bipyridyl isomers and use this data to identify a trace alkaloidal constituent of Aa as 3-methyl-2,3'-bipyridyl. This is only the second reported instance of a methyl-bipyridyl being found as a natural product, the first being the tobacco alkaloid 5-methyl-2,3'-bipyridyl.
C1 [Kem, William R.; Soti, Ferenc] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA.
[Rocca, James] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA.
[Garraffo, H. Martin; Spande, Thomas F.; Daly, John W.] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
RP Kem, WR (reprint author), Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA.
EM wrkem@ufl.edu
FU Florida SeaGrants [R/RL-MB-9, MB-16, MB-20]; NIDDK/NIH
FX We thank Eric Kern and Robert Bosien for their assistance in collecting
the Amphiporus angulatus at numerous low tides, often in harsh weather
and dim light. We are also grateful to Roy King and James Duncan (both
UF) for obtaining the initial direct probe introduction El mass spectra
and high resolution mass determinations of the methyl-bipyridyl natural
product. Barbara Seymour provided the nemertine drawing for the
graphical abstract and Anne Rouchaud assisted in the preparation of the
figures. This research was supported by Florida SeaGrants R/RL-MB-9,
MB-16 and MB-20 to the Kem lab and NIDDK/NIH intramural funds to the
Daly lab.
NR 35
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U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 1025
EP 1041
DI 10.3987/COM-08-S(D)80
PG 17
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200084
ER
PT J
AU Iyer, MR
Deschamps, JR
Jacobson, AE
Rice, KC
AF Iyer, Malliga R.
Deschamps, Jeffrey R.
Jacobson, Arthur E.
Rice, Kenner C.
TI PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 38. AN EXPEDITIOUS
SYNTHESIS OF
RAC-CIS-4a-ETHYL-2-METHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYRIDIN
-6-OL AND
RAC-CIS-2-METHYL-4a-PHENETHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYR
IDIN-6-OL
SO HETEROCYCLES
LA English
DT Article
DE cis-Benzofuropyridin-6-ol and Analogue; Synthesis; Structurally Rigid
Compound; C-4a Phenethyl Analogue; X-Ray Crystallographic Structure
ID OXIDE-BRIDGED 5-(META-HYDROXYPHENYL)MORPHAN; N-PHENETHYL ANALOGS;
PHENYLMORPHANS; PARKINSONISM; AFFINITY
AB A high-yielding five-step synthesis of cis-benzofuropyridin-6-ols provided an improved route to compounds with low to subnanomolar affinity at opioid receptors and high antinociceptive potency. This synthesis provided the known rac-cis-4a-etbyl-2-methyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3c]pyridin-6-ol (1a) in high yield, and the novel rac-cis-2-methyl-4a-phenethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ol (1b). It was achieved using NBS to prepare the key intermediate 7. Di-demethylation followed by subsequent displacement of the bromine by the phenolic ion in hot Et(3)N gave the desired 1a. The structure of la was confirmed by X-ray crystallography.
C1 [Iyer, Malliga R.; Jacobson, Arthur E.; Rice, Kenner C.] Natl Inst Drug Abuse, Drug Design & Synth Sect, Chem Biol Res Branch, Bethesda, MD 20892 USA.
[Iyer, Malliga R.; Jacobson, Arthur E.; Rice, Kenner C.] NIAAA, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Deschamps, Jeffrey R.] USN, Res Lab, Struct Matter Lab, Washington, DC 20375 USA.
RP Iyer, MR (reprint author), Natl Inst Drug Abuse, Drug Design & Synth Sect, Chem Biol Res Branch, 5625 Fishers Lane,Room 4N03, Bethesda, MD 20892 USA.
EM kr21f@nih.gov
FU National Institute on Drug Abuse (NIDA)
FX We would like to thank Dr. Klaus Gawrisch and Dr. Walter Teague of the
Laboratory of Membrane Biochemistry and Biophysics, NIAAA, for NMR
spectral data. The authors also express their thanks to Noel Whittaker
and Wesley White of the Laboratory of Analytical Chemistry, NIDDK, for
mass spectral data and 1H NNM spectral data. The work of the
Drug Design and Synthesis Section, CBRB, NIDA, & NIAAA, was supported by
the NIH Intramural Research Programs of the National Institute on Drug
Abuse (NIDA) and the National Institute of Alcohol Abuse and Alcoholism.
X-ray crystallographic work was supported by NIDA under contract
YI-DA6002.
NR 13
TC 4
Z9 4
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0385-5414
J9 HETEROCYCLES
JI Heterocycles
PD APR 1
PY 2009
VL 79
BP 1061
EP 1072
DI 10.3987/COM-09-S(D)84
PG 12
WC Chemistry, Organic
SC Chemistry
GA 452TN
UT WOS:000266564200086
PM 20101277
ER
PT J
AU Frey, A
Soubani, AO
Adam, AK
Sheng, S
Pass, HI
Lonardo, F
AF Frey, Amy
Soubani, Ayman O.
Adam, Abdulgadir K.
Sheng, Shijie
Pass, Harvey I.
Lonardo, Fulvio
TI Nuclear, compared with combined nuclear and cytoplasmic expression of
maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in
Stage I, improved survival
SO HISTOPATHOLOGY
LA English
DT Article
DE lung adenocarcinoma; maspin; p53; prognosis; Stage I; subcellular
localization; VEGF-A
ID TUMOR-SUPPRESSOR GENE; BREAST-CANCER; PULMONARY ADENOCARCINOMA;
PROGNOSTIC-SIGNIFICANCE; EPITHELIAL-CELLS; DOWN-REGULATION;
POOR-PROGNOSIS; MESSENGER-RNA; PROGRESSION; CARCINOMA
AB To evaluate whether there is a correlation between the subcellular localization of maspin and the histological, molecular and biological features of pulmonary adenocarcinoma, particularly addressing the hypothesis that the tumour inhibitor properties of maspin may be linked to a nuclear, compared with a combined nuclear and cytoplasmic expression pattern.
The subcellular expression of maspin was determined in 80 resected pulmonary adenocarcinomas (Stage I, 46; Stage II, 10; Stage III, 20; Stage IV, 4) and correlated with histological grade, proliferative rate, p53 expression, vascular endothelial growth factor (VEGF)-A levels, and prognosis (mean follow-up of 41.5 months). Cases with nuclear (N) maspin (n = 47), compared with the [N + cytoplasmic (C)] group (n = 28), showed lower (P <= 0.05): histological grade, proliferative rate, p53 expression and VEGF-A levels. Cox multivariate analysis revealed in stage I adenocarcinomas (N) maspin as the only predictor of improved survival.
(N) maspin selects lung adenocarcinomas with distinct molecular and clinical features, supporting the hypothesis that its tumour inhibitor properties may be linked to its nuclear localization.
C1 [Lonardo, Fulvio] Wayne State Univ, Karmanos Canc Inst, Dept Pathol, Harper Univ Hosp, Detroit, MI 48201 USA.
[Soubani, Ayman O.; Adam, Abdulgadir K.] Wayne State Univ, Div Pulm Allergy Crit Care & Sleep Med, Dept Internal Med, Harper Univ Hosp, Detroit, MI 48201 USA.
Barbara Ann Karmanos Canc Inst, Detroit, MI USA.
[Pass, Harvey I.] NYU, Ctr Comprehens Canc, NCI, Div Thorac Surg,Dept Cardiothorac Surg, New York, NY USA.
[Pass, Harvey I.] NYU, Ctr Comprehens Canc, NCI, Div Thorac Oncol,Dept Cardiothorac Surg, New York, NY USA.
RP Lonardo, F (reprint author), Wayne State Univ, Karmanos Canc Inst, Dept Pathol, Harper Univ Hosp, 3990 John R, Detroit, MI 48201 USA.
EM flonardo@med.wayne.edu
FU NCI NIH HHS [R01 CA084176, R01 CA084176-07]
NR 35
TC 19
Z9 20
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0309-0167
J9 HISTOPATHOLOGY
JI Histopathology
PD APR
PY 2009
VL 54
IS 5
BP 590
EP 597
DI 10.1111/j.1365-2559.2009.03260.x
PG 8
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA 431AQ
UT WOS:000265034100008
PM 19309490
ER
PT J
AU Siervo, M
Wells, JCK
Cizza, G
AF Siervo, M.
Wells, J. C. K.
Cizza, G.
TI The Contribution of Psychosocial Stress to the Obesity Epidemic: An
Evolutionary Approach
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE adiposity; neuro-endocrine stress response; thrifty genotype; energy
sensing; energy balance
ID BODY-MASS INDEX; BROWN ADIPOSE-TISSUE; ACTIVATED PROTEIN-KINASE;
FOOD-INTAKE; INDUSTRIAL-REVOLUTION; ENERGY HOMEOSTASIS; METABOLIC
SYNDROME; THRIFTY GENOTYPES; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE
AB The Thrifty Gene hypothesis theorizes that during evolution a set of genes has been selected to ensure survival in environments with limited food supply and marked seasonality. Contemporary environments have predictable and Unlimited food availability, an attenuated seasonality due to artificial lighting, indoor heating during the winter and air conditioning during the summer, and promote sedentariness and overeating. In this setting the thrifty genes are constantly activated to enhance energy storage. Psychosocial stress and sleep deprivation are other features of modern societies. Stress-induced hypercortisolemia in the setting Of Unlimited food supply promotes adiposity. Modern man is becoming obese because these ancient mechanisms are efficiently promoting a positive energy balance. We propose that in today's plentifully provisioned societies, where sedentariness and mental stress have become typical traits, chronic activation of the neuroendocrine systems may contribute to the increased prevalence of obesity. We suggest that some of the yet Unidentified thrifty genes may be linked to highly conserved energy sensing mechanisms (AMP kinase, mTOR kinase). These hypotheses are testable. Rural societies that are becoming rapidly industrialized and are witnessing a dramatic increase in obesity may provide a historical opportunity to conduct epidemiological studies of the thrifty genotype. In experimental settings, the effects of various forms of psychosocial stress in increasing metabolic efficiency and gene expression can be further tested.
C1 [Cizza, G.] NIDDK, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
[Siervo, M.] Addenbrookes Hosp, Cambridge, England.
[Wells, J. C. K.] Inst Child Hlth, Childhood Nutr Res Ctr, London WC1N 1EH, England.
RP Cizza, G (reprint author), NIDDK, Clin Endocrinol Branch, NIH, Bldg 10,CRC 6-3940,10 Ctr Dr, Bethesda, MD 20892 USA.
EM cizzag@intra.niddk.nih.gov
RI Wells, Jonathan/A-4604-2009
OI Wells, Jonathan/0000-0003-0411-8025
FU National Institute of Diabetes, Digestive and Kidney Diseases
FX This research was supported in part by the Intramural Research Programs
of the National Institute of Diabetes, Digestive and Kidney Diseases.
NR 127
TC 45
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U1 1
U2 15
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD APR
PY 2009
VL 41
IS 4
BP 261
EP 270
DI 10.1055/s-0028-1119377
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 438AI
UT WOS:000265527900001
PM 19156597
ER
PT J
AU Pacak, K
Eisenhofer, G
Ilias, I
AF Pacak, Karel
Eisenhofer, Graeme
Ilias, Ioannis
TI Diagnosis of pheochromocytoma with special emphasis on MEN2 syndrome
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Multiple endocrine neoplasia; Paraganglioma; Pheochromocytoma;
Positron-emission tomography
ID HIPPEL-LINDAU-SYNDROME; POSITRON-EMISSION-TOMOGRAPHY;
BIOCHEMICAL-DIAGNOSIS; PLASMA METANEPHRINES; METASTATIC
PHEOCHROMOCYTOMA; LOCALIZATION; PARAGANGLIOMAS; SCINTIGRAPHY; EXPRESSION
AB Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare but treacherous catecholamine-producing tumors which, if overlooked or improperly treated, will almost invariably prove fatal. Patients with MEN2 PHEOs have a high incidence of paroxysmal attacks and a higher prevalence of hypertension and other cardiovascular problems than do patients with Von-Hippel-Lindau (VHL) PHEOs. Compared to measurements of deconjugated metanephrines, plasma concentrations of free metanephrines are relatively independent of renal function and therefore more suitable for diagnosis of PHEO/PGL. Recently, the focus of Positron Emission Tomography (PET) imaging for these tumors has been the localization of PHEO. Although a limited number of studies are available, [F-18]-fluorodopamine ([F-18]DA) PET has been found to be the best overall imaging modality in the localization of PHEO. For adrenal PHEOs, this method seems to be comparable to other functional modalities such as [F-18]-fluorodopa ([F-18]DOPA) PET or [I-123]-metaiodobenzylguanidine ([I-123]MIBG) scintigraphy. For extraadrenal PHEOs, data are limited and more extensive studies are needed. In patients with metastatic PHEO, the sensitivity of [F-18] DA PET is superior to [I-123] MIBG. The so called "flip-flop" imaging showing superiority of non-specific [F-18] flurodeoxyglucose (FDG) PET over specific [F-18] DA PET has been described in rapidly progressive, often metastatic SDHB-associated PHEOs. Whether these data reflect PHEO cell dedifferentiation (e.g. losing Norepinephrine Transporter - NET) or increased metabolic rate remains to be established.
C1 [Pacak, Karel] NICHD, NIH, Reprod & Adult Endocrinol Program, Sect Med Neuroendocrinol, Bethesda, MD USA.
[Eisenhofer, Graeme] Univ Dresden, Dept Med, Inst Clin Chem & Lab Med, Dresden, Germany.
[Ilias, Ioannis] Elena Venizelou Hosp, Dept Endocrinol, Athens 11521, Greece.
RP Ilias, I (reprint author), Elena Venizelou Hosp, Dept Diabet Endocrinol & Metab, 2 El Venizelou Sq, Athens 11521, Greece.
EM iiliasmd@yahoo.com
FU Intramural NIH HHS [Z01 HD008735-08]
NR 36
TC 12
Z9 15
U1 0
U2 1
PU HELLENIC ENDOCRINE SOC
PI ATHENS
PA 14 ALEXANDRAS AVE, ATHENS, 106 82, GREECE
SN 1109-3099
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD APR-JUN
PY 2009
VL 8
IS 2
BP 111
EP 116
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 463IM
UT WOS:000267425600003
PM 19570738
ER
PT J
AU Klauschen, F
Goldman, A
Barra, V
Meyer-Lindenberg, A
Lundervold, A
AF Klauschen, Frederick
Goldman, Aaron
Barra, Vincent
Meyer-Lindenberg, Andreas
Lundervold, Arvid
TI Evaluation of Automated Brain MR Image Segmentation and Volumetry
Methods
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE structural MRI; segmentation; accuracy; volumetry
ID MAGNETIC-RESONANCE IMAGES; VOXEL-BASED MORPHOMETRY; SURFACE-BASED
ANALYSIS; HUMAN CEREBRAL-CORTEX; LEVEL-SET METHOD; MULTISPECTRAL
ANALYSIS; CLASSIFICATION METHODS; DISCRIMINANT-ANALYSIS; TISSUE
SEGMENTATION; PATTERN-RECOGNITION
AB We compare three widely used brain volumetry methods available in the software packages FSL, SPM5, and FreeSurfer and evaluate their performance using simulated and real MR brain data sets. We analyze the accuracy of gray and white matter Volume measurements and their robustness against changes of image quality using the BrainWeb MRI database. These images are based on "gold-standard" reference brain templates. This allows us to assess between- (same data set, different method) and also within-segmenter (same method, variation of image quality) comparability, for both of which we find pronounced variations in segmentation results for gray and white matter volumes. The calculated volumes deviate up to >10% from the reference values for gray and white matter depending on method and image quality. Sensitivity is best for SPM5, volumetric accuracy for gray and white matter was similar in SPM5 and FSL and batter than in FreeSurfer. FSL showed the highest stability for white (<5%), FreeSurfer (6.2%) for gray matter for constant image quality BrainWeb data. Between-segmenter comparisons show discrepancies of Lip to >20% for the simulated data and 24% on average for the real data sets, whereas within-method performance analysis uncovered volume differences of tip to >15%. Since the discrepancies between results reach the same order of magnitude as volume changes observed in disease, these effects limit the usability of the segmentation methods for following volume changes in individual patients over time and should be taken into account during the planning and analysis of brain volume studies. Hum Brain Mapp 30:1310-1327, 2009. (C) 2008 Wiley-Liss, Inc.
C1 [Klauschen, Frederick; Goldman, Aaron; Meyer-Lindenberg, Andreas] NIMH, NIH, Neuroimaging Core Facil, Genes Cognit & Psychosis Program, Bethesda, MD 20892 USA.
[Klauschen, Frederick; Lundervold, Arvid] Univ Bergen, Dept Biomed, Neuroinformat & Image Anal Lab, Bergen, Norway.
[Meyer-Lindenberg, Andreas] Zent Inst Seel Gesundheit, D-6800 Mannheim, Germany.
[Barra, Vincent] Univ Clermont Ferrand, CNRS, LIMOS, UMR 6158, Aubiere, France.
RP Klauschen, F (reprint author), NIMH, NIH, Neuroimaging Core Facil, Genes Cognit & Psychosis Program, 9000 Rockville Pike,10-11N311, Bethesda, MD 20892 USA.
EM fklauschen@mail.nih.gov
RI Klauschen, Frederick/C-5637-2015; Meyer-Lindenberg, Andreas/H-1076-2011
OI Meyer-Lindenberg, Andreas/0000-0001-5619-1123
FU NIMH/IRP; The Research Council of Norway [Aur06-11]; France-Norway
AURORA Project
FX Contract grant sponsors: NIMH/IRP and The Research Council of Norway
(Aur06-11), France-Norway AURORA Project.
NR 70
TC 107
Z9 110
U1 1
U2 13
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD APR
PY 2009
VL 30
IS 4
BP 1310
EP 1327
DI 10.1002/hbm.20599
PG 18
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 426GP
UT WOS:000264696300023
PM 18537111
ER
PT J
AU Carroll, N
Pangilinan, F
Molloy, A
Troendle, J
Mills, J
Kirke, P
Brody, L
Scott, J
Parle-McDermott, A
AF Carroll, Nicola
Pangilinan, Faith
Molloy, Anne M.
Troendle, James
Mills, James L.
Kirke, Peadar N.
Brody, Lawrence C.
Scott, John M.
Parle-McDermott, Anne
TI Analysis of the MTHFD1 promoter and risk of neural tube defects
SO HUMAN GENETICS
LA English
DT Article
ID DEHYDROGENASE-METHENYLTETRAHYDROFOLATE-CYCLOHYDROLASE;
MOLECULAR-GENETIC-ANALYSIS; METHYLENETETRAHYDROFOLATE-DEHYDROGENASE;
TRIFUNCTIONAL ENZYME; CPG ISLAND; FORMYLTETRAHYDROFOLATE SYNTHETASE;
R653Q POLYMORPHISM; FOLATE; POPULATION; METABOLISM
AB Genetic variants in MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase/ 10-formyltetrahydrofolate synthetase), an important folate metabolic enzyme, are associated with a number of common diseases, including neural tube defects (NTDs). This study investigates the promoter of the human MTHFD1 gene in a bid to understand how this gene is controlled and regulated. Following a combination of in silico and molecular approaches, we report that MTHFD1 expression is controlled by a TATA-less, Initiator-less promoter and transcription is initiated at multiple start sites over a 126 bp region. We confirmed the presence of three database polymorphisms (dbSNP) by direct sequencing of the upstream region (rs1076991 C > T, rs8010584 G > A, rs4243628 G > T), with a fourth (dbSNP rs746488 A > T) not found to be polymorphic in our population and no novel polymorphisms identified. We demonstrate that a common SNP rs1076991 C > T within the window of transcriptional initiation exerts a significant effect on promoter activity in vitro. We investigated this SNP as a potential risk factor for NTDs in a large homogenous Irish population and determined that it is not an independent risk factor, but, it does increase both case (chi (2) = 11.06, P = 0.001) and maternal (chi (2) = 6.68, P = 0.01) risk when allele frequencies were analysed in combination with the previously identified disease-associated p.R653Q (c.1958 G > A; dbSNP rs2236225) polymorphism. These results provide the first insight into how MTHFD1 is regulated and further emphasise its importance during embryonic development.
C1 [Carroll, Nicola; Parle-McDermott, Anne] Dublin City Univ, Sch Biotechnol, Nutr Genom Grp, Dublin 9, Ireland.
[Pangilinan, Faith; Brody, Lawrence C.] Natl Human Genome Res Inst, Genome Technol Branch, Mol Pathogenesis Sect, Bethesda, MD 20892 USA.
[Molloy, Anne M.] Trinity Coll Dublin, Sch Med, Dublin 2, Ireland.
[Troendle, James; Mills, James L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
[Kirke, Peadar N.] Hlth Res Board, Child Hlth Epidemiol Div, Dublin, Ireland.
[Scott, John M.] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland.
RP Parle-McDermott, A (reprint author), Dublin City Univ, Sch Biotechnol, Nutr Genom Grp, Dublin 9, Ireland.
EM anne.parle-mcdermott@dcu.ie
OI Molloy, Anne/0000-0002-1688-9049
FU NICHD; NIH; Health Research Board of Ireland; Research Ethics Committee
of the Health Research Board
FX We wish to thank the Irish Association for Spina Bifida and
Hydrocephalus and the Public Health Nurses for assistance with subject
recruitment and the following Dublin maternity hospitals for control
recruitment: National Maternity Hospital Holles street, the Coombe
Womens' Hospital and the Rotunda Hospital. This research was supported
by the Intramural Research Program of the NICHD, NIH and the Health
Research Board of Ireland. Approval was obtained from the Research
Ethics Committee of the Health Research Board, Ireland and the
Institutional Review Board at the National Institutes of Health. All
research participants provided informed consent.
NR 34
TC 19
Z9 20
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
J9 HUM GENET
JI Hum. Genet.
PD APR
PY 2009
VL 125
IS 3
BP 247
EP 256
DI 10.1007/s00439-008-0616-3
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 423EW
UT WOS:000264480500002
PM 19130090
ER
PT J
AU Sezgin, E
Lind, JM
Shrestha, S
Hendrickson, S
Goedert, JJ
Donfield, S
Kirk, GD
Phair, JP
Troyer, JL
O'Brien, SJ
Smith, MW
AF Sezgin, Efe
Lind, Joanne M.
Shrestha, Sadeep
Hendrickson, Sher
Goedert, James J.
Donfield, Sharyne
Kirk, Gregory D.
Phair, John P.
Troyer, Jennifer L.
O'Brien, Stephen J.
Smith, Michael W.
TI Association of Y chromosome haplogroup I with HIV progression, and HAART
outcome
SO HUMAN GENETICS
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; AUTOIMMUNE-DISEASE; GENETIC RESTRICTION;
INFECTIOUS-DISEASES; NATURAL-HISTORY; VIRAL LOAD; AIDS; ANTIGEN;
SEROCONVERSION; POPULATIONS
AB The host genetic basis of differential outcomes in HIV infection, progression, viral load set point and highly active retroviral therapy (HAART) responses was examined for the common Y haplogroups in European Americans and African Americans. Accelerated progression to acquired immune deficiency syndrome (AIDS) and related death in European Americans among Y chromosome haplogroup I (Y-I) subjects was discovered. Additionally, Y-I haplogroup subjects on HAART took a longer time to HIV-1 viral suppression and were more likely to fail HAART. Both the accelerated progression and longer time to viral suppression results observed in haplogroup Y-I were significant after false-discovery-rate corrections. A higher frequency of AIDS-defining illnesses was also observed in haplogroup Y-I. These effects were independent of the previously identified autosomal AIDS restriction genes. When the Y-I haplogroup subjects were further subdivided into six I subhaplogroups, no one subhaplogroup accounted for the effects on HIV progression, viral load or HAART response. Adjustment of the analyses for population stratification found significant and concordant haplogroup Y-I results. The Y chromosome haplogroup analyses of HIV infection and progression in African Americans were not significant. Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans.
C1 [Sezgin, Efe; Lind, Joanne M.; Shrestha, Sadeep; Hendrickson, Sher; Goedert, James J.; Donfield, Sharyne; Smith, Michael W.] NCI, Lab Genom Divers, Frederick, MD 21702 USA.
[Shrestha, Sadeep; Troyer, Jennifer L.; Smith, Michael W.] SAIC Frederick Inc, NCI Frederick, Basic Res Program, Frederick, MD 21702 USA.
[Goedert, James J.] NCI, Viral Epidemiol Branch, Rockville, MD 20582 USA.
[Donfield, Sharyne] Rho Inc, Chapel Hill, NC 27517 USA.
[Kirk, Gregory D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Phair, John P.] Northwestern Univ, Sch Med, Comprehens AIDS Ctr, Chicago, IL 60611 USA.
RP Smith, MW (reprint author), SAIC Frederick Inc, Adv Technol Program, NCI, Genet & Genom, 915 Tollhouse Ave,Suite 211, Frederick, MD 21701 USA.
EM smithmw@mail.nih.gov
RI Smith, Michael/B-5341-2012; Sezgin, Efe/B-8418-2012; Troyer,
Jennifer/B-8415-2012
OI Sezgin, Efe/0000-0002-8000-7485;
FU National Cancer Institute; National Institutes of Health [N01-CO-12400];
NIH/NCICHD [1 R01 HD41224]
FX We thank the patients and staff of all the participating cohorts in the
study. San Francisco City Cohort samples were provided by Susan
Buchbinder. We thank Drs. George W. Nelson, James Lautenberger, Cheryl
Winkler, Taras Oleksyk and Yvette Berthier-Schaad for helpful
discussions. We are also grateful to Ann Truelove, Viktoriya Grinberg,
Randy Johnson, Bailey Kessing, Michael Malasky, and Mary Thompson for
their assistance. The content of this publication does not necessarily
reflect the views or policies of the Department of Health and Human
Services, nor does mention of trade names, commercial products, or
organizations imply endorsement by the U. S. government. The project
described in this manuscript has been funded in whole or in part with
federal funds from the National Cancer Institute, National Institutes of
Health, under contract N01-CO-12400. The HGDS is supported by 1 R01
HD41224, NIH/NCICHD.
NR 64
TC 14
Z9 14
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD APR
PY 2009
VL 125
IS 3
BP 281
EP 294
DI 10.1007/s00439-008-0620-7
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA 423EW
UT WOS:000264480500005
PM 19169712
ER
PT J
AU Hagemann, TL
Boelens, WC
Wawrousek, EF
Messing, A
AF Hagemann, Tracy L.
Boelens, Wilbert C.
Wawrousek, Eric F.
Messing, Albee
TI Suppression of GFAP toxicity by alpha B-crystallin in mouse models of
Alexander disease
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID HEAT-SHOCK-PROTEIN; FIBRILLARY ACIDIC PROTEIN; ROSENTHAL FIBERS;
MOLECULAR CHAPERONES; SIGNALING PATHWAYS; TRANSGENIC MICE;
STRESS-RESPONSE; EXPRESSION; ACTIVATION; GENE
AB Alexander disease (AxD) is a primary disorder of astrocytes caused by dominant mutations in the gene for glial fibrillary acidic protein (GFAP). These mutations lead to protein aggregation and formation of Rosenthal fibers, complex astrocytic inclusions that contain GFAP, vimentin, plectin, ubiquitin, Hsp27 and alpha B-crystallin. The small heat shock protein alpha B-crystallin (Cryab) regulates GFAP assembly, and elevation of Cryab is a consistent feature of AxD; however, its role in Rosenthal fibers and AxD pathology is not known. Here, we show in AxD mouse models that loss of Cryab results in increased mortality, whereas elevation of Cryab rescues animals from terminal seizures. When mice with Rosenthal fibers induced by over-expression of GFAP are crossed into a Cryab-null background, over half die at 1 month of age. Restoration of Cryab expression through the GFAP promoter reverses this outcome, showing the effect is astrocyte-specific. Conversely, in mice engineered to express both AxD-associated mutations and elevated GFAP, which despite natural induction of Cryab also die at 1 month, transgenic over-expression of Cryab results in a markedly reduced CNS stress response, restores expression of the glutamate transporter Glt1 (EAAT2) and protects these animals from death. In its most common form, AxD is a devastating neurodegenerative disease, with early onset, characterized by seizures, spasticity and developmental delays, ultimately leading to death. Cryab plays a critical role in tempering AxD pathology and should be investigated as a therapeutic target for this and other diseases with astropathology.
C1 [Hagemann, Tracy L.; Messing, Albee] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[Messing, Albee] Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53705 USA.
[Boelens, Wilbert C.] Radboud Univ Nijmegen, Nijmegen Ctr Mol Life Sci, Dept Biomol Chem 271, NL-6500 HB Nijmegen, Netherlands.
[Wawrousek, Eric F.] NEI, NIH, DHHS, Bethesda, MD 20892 USA.
RP Hagemann, TL (reprint author), Univ Wisconsin, Waisman Ctr 715, 1500 Highland Ave, Madison, WI 53705 USA.
EM hagemann@waisman.wisc.edu
RI Boelens, Wilbert/D-8877-2012
FU NICHD NIH HHS [HD03352]; NINDS NIH HHS [NS060120, NS42803, P01 NS042803,
R01 NS060120]
NR 53
TC 54
Z9 55
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 1
PY 2009
VL 18
IS 7
BP 1190
EP 1199
DI 10.1093/hmg/ddp013
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 421XI
UT WOS:000264391200002
PM 19129171
ER
PT J
AU Kaput, J
Cotton, RGH
Hardman, L
Watson, M
Al Aqeel, AI
Al-Aama, JY
Al-Mulla, F
Alonso, S
Aretz, S
Auerbach, AD
Bapat, B
Bernstein, IT
Bhak, J
Bleoo, SL
Blocker, H
Brenner, SE
Burn, J
Bustamante, M
Calone, R
Cambon-Thomsen, A
Cargill, M
Carrera, P
Cavedon, L
Cho, YS
Chung, YJ
Claustres, M
Cutting, G
Dalgleish, R
den Dunnen, JT
Diaz, C
Dobrowolski, S
dos Santos, MRN
Ekong, R
Flanagan, SB
Flicek, P
Furukawa, Y
Genuardi, M
Ghang, H
Golubenko, MV
Greenblatt, MS
Hamosh, A
Hancock, JM
Hardison, R
Harrison, TM
Hoffmann, R
Horaitis, R
Howard, HJ
Barash, CI
Izagirre, N
Jung, J
Kojima, T
Laradi, S
Lee, YS
Lee, JY
Gil-da-Silva-Lopes, VL
Macrae, FA
Maglott, D
Marafie, MJ
Marsh, SGE
Matsubara, Y
Messiaen, LM
Moslein, G
Netea, MG
Norton, ML
Oefner, PJ
Oetting, WS
O'Leary, JC
de Ramirez, AMO
Paalman, MH
Parboosingh, J
Patrinos, GP
Perozzi, G
Phillips, IR
Povey, S
Prasad, S
Qi, M
Quin, DJ
Ramesar, RS
Richards, CS
Savige, J
Scheible, DG
Scott, RJ
Seminara, D
Shephard, EA
Sijmons, RH
Smith, TD
Sobrido, MJ
Tanaka, T
Tavtigian, SV
Taylor, GR
Teague, J
Topel, T
Ullman-Cullere, M
Utsunomiya, J
van Kranen, HJ
Vihinen, M
Webb, E
Weber, TK
Yeager, M
Yeom, YI
Yim, SH
Yoo, HS
AF Kaput, Jim
Cotton, Richard G. H.
Hardman, Lauren
Watson, Michael
Al Aqeel, Aida I.
Al-Aama, Jumana Y.
Al-Mulla, Fahd
Alonso, Santos
Aretz, Stefan
Auerbach, Arleen D.
Bapat, Bharati
Bernstein, Inge T.
Bhak, Jong
Bleoo, Stacey L.
Bloecker, Helmut
Brenner, Steven E.
Burn, John
Bustamante, Mariona
Calone, Rita
Cambon-Thomsen, Anne
Cargill, Michele
Carrera, Paola
Cavedon, Lawrence
Cho, Yoon Shin
Chung, Yeun-Jun
Claustres, Mireille
Cutting, Garry
Dalgleish, Raymond
den Dunnen, Johan T.
Diaz, Carlos
Dobrowolski, Steven
dos Santos, M. Rosario N.
Ekong, Rosemary
Flanagan, Simon B.
Flicek, Paul
Furukawa, Yoichi
Genuardi, Maurizio
Ghang, Ho
Golubenko, Maria V.
Greenblatt, Marc S.
Hamosh, Ada
Hancock, John M.
Hardison, Ross
Harrison, Terence M.
Hoffmann, Robert
Horaitis, Rania
Howard, Heather J.
Barash, Carol Isaacson
Izagirre, Neskuts
Jung, Jongsun
Kojima, Toshio
Laradi, Sandrine
Lee, Yeon-Su
Lee, Jong-Young
Gil-da-Silva-Lopes, Vera L.
Macrae, Finlay A.
Maglott, Donna
Marafie, Makia J.
Marsh, Steven G. E.
Matsubara, Yoichi
Messiaen, Ludwine M.
Moeslein, Gabriela
Netea, Mihai G.
Norton, Melissa L.
Oefner, Peter J.
Oetting, William S.
O'Leary, James C.
Oller de Ramirez, Ana Maria
Paalman, Mark H.
Parboosingh, Jillian
Patrinos, George P.
Perozzi, Giuditta
Phillips, Ian R.
Povey, Sue
Prasad, Suyash
Qi, Ming
Quin, David J.
Ramesar, Rajkumar S.
Richards, C. Sue
Savige, Judith
Scheible, Dagmar G.
Scott, Rodney J.
Seminara, Daniela
Shephard, Elizabeth A.
Sijmons, Rolf H.
Smith, Timothy D.
Sobrido, Maria-Jesus
Tanaka, Toshihiro
Tavtigian, Sean V.
Taylor, Graham R.
Teague, Jon
Toepel, Thoralf
Ullman-Cullere, Mollie
Utsunomiya, Joji
van Kranen, Henk J.
Vihinen, Mauno
Webb, Elizabeth
Weber, Thomas K.
Yeager, Meredith
Yeom, Young I.
Yim, Seon-Hee
Yoo, Hyang-Sook
CA Human Variome Project Planning
TI Planning the Human Variome Project: The Spain Report
SO HUMAN MUTATION
LA English
DT Review
DE variome; genome; mutation; database; genetic disease
ID INTERNATIONAL HAPMAP PROJECT; LOCUS-SPECIFIC DATABASES; HUMAN GENOME;
DEVELOPING-COUNTRIES; GLOBAL HEALTH; GENETIC-VARIATION; MISSENSE
VARIANTS; MUTATION DATABASE; GRAND CHALLENGES; HUMAN-DISEASE
AB The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data from diverse studies proves this perception inaccurate at best, and at worst, an impediment for further efforts to characterize the variation in the human genome. Because variation in genotype and environment are the fundamental basis to understand phenotypic variability and heritability at the population level, identifying the range of human genetic variation is crucial to the development of personalized nutrition and medicine. The Human Variome Project (HVP; http://www.humanvariomeproject.org/) was proposed initially to systematically collect mutations that cause human disease and create a cyber infrastructure to link locus specific databases (LSDB). We report here the discussions and recommendations from the 2008 HVP planning meeting held in San Feliu de Guixols Spain, in May 2008. Hum Mutat 30, 496-510, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Kaput, Jim] US FDA, Natl Ctr Toxicol Res, Div Personalized Nutr & Med, Jefferson, AR 72079 USA.
[Cotton, Richard G. H.; Hardman, Lauren; Horaitis, Rania; Howard, Heather J.; Smith, Timothy D.; Webb, Elizabeth] Genom Disorders Res Ctr, Melbourne, Vic, Australia.
[Cotton, Richard G. H.] Univ Melbourne, Fac Med Dent & Hlth Sci, Parkville, Vic 3052, Australia.
[Watson, Michael] Amer Coll Med Genet, Bethesda, MD USA.
[Al Aqeel, Aida I.] Riyadh Mil Hosp, Dept Paediat, Riyadh, Saudi Arabia.
[Al-Aama, Jumana Y.] King Abdulaziz Univ, Princess Al Jawhara Ctr Hereditary Disorders, Jeddah, Saudi Arabia.
[Al-Mulla, Fahd] Kuwait Univ, Mol Pathol Unit, Kuwait, Kuwait.
[Alonso, Santos] Univ Basque Country, Dept Genet Phys Anthropol & Anim Physiol, Madrid, Spain.
[Aretz, Stefan] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany.
[Auerbach, Arleen D.] Rockefeller Univ, Lab Human Genet & Hematol, New York, NY 10021 USA.
[Bapat, Bharati] Univ Toronto, Mt Sinai Hosp, Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada.
[Bernstein, Inge T.] Hvidovre Univ Hosp, Copenhagen, Denmark.
[Bhak, Jong; Ghang, Ho] KRIBB, Korean Bioinformat Ctr, Chungnam, South Korea.
[Bleoo, Stacey L.] Univ Alberta, Edmonton, AB, Canada.
[Bloecker, Helmut] HZI Helmholtz Ctr Infect Res, Braunschweig, Germany.
[Brenner, Steven E.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Bustamante, Mariona] Ctr Genom Regulat, Barcelona, Spain.
[Bustamante, Mariona] Ctr Network Biomed Res Epidemiol & Publ Hlth, Barcelona, Spain.
[Calone, Rita] Genet Serv ASL, Naples, Italy.
[Cargill, Michele] Navigenics, Human Genet, Redwood Shores, CA USA.
[Cambon-Thomsen, Anne] Fac Med Toulouse, INSERM, F-31073 Toulouse, France.
[Carrera, Paola] Ist Sci San Raffaele, Unit Genom Diagnost Human Dis & Laboraf, I-20132 Milan, Italy.
[Cavedon, Lawrence] NICTA, Victorian Res Lab, Parkville, Vic, Australia.
[Cho, Yoon Shin; Jung, Jongsun; Lee, Jong-Young] Korean Natl Inst Hlth, Div Struct & Funct Genom, Seoul, South Korea.
[Chung, Yeun-Jun] Catholic Univ Korea, Dept Microbiol & Genom, Seoul, South Korea.
[Claustres, Mireille] Univ Montpellier 1, Fac Med, Montpellier, France.
[Claustres, Mireille] CHU Montpellier, Genet Mol Lab, Montpellier, France.
[Cutting, Garry; Hamosh, Ada] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD USA.
[Dalgleish, Raymond] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England.
[den Dunnen, Johan T.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
[Diaz, Carlos] Fundacio IMIM, European Project Management & Coordinat Off, Barcelona, Spain.
[Dobrowolski, Steven] Idaho Technol Inc, Res & Dev, Salt Lake City, UT USA.
[Ekong, Rosemary] UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England.
[Flanagan, Simon B.; Povey, Sue] Royal Brisbane & Womens Hosp, Herston, Qld, Australia.
[Flicek, Paul] EMBL European Bioinformat Inst, Hinxton, England.
[Furukawa, Yoichi] Univ Tokyo, Inst Med Sci, Div Clin Genom Res, Tokyo 1138654, Japan.
[Genuardi, Maurizio] Univ Florence, I-50121 Florence, Italy.
[Golubenko, Maria V.] Inst Med Genet, Tomsk, Russia.
[Greenblatt, Marc S.] Univ Vermont, Coll Med, Burlington, VT USA.
[Hamosh, Ada] Johns Hopkins Univ, OMIM, Baltimore, MD USA.
[Hancock, John M.] MRC Harwell, Bioinformat Grp, Harwell, Berks, England.
[Hardison, Ross] Penn State Univ, University Pk, PA 16802 USA.
[Harrison, Terence M.] Royal Melbourne Hosp, Hlth Sci Lib, Parkville, Vic 3050, Australia.
[Harrison, Terence M.] Royal Melbourne Hosp, Victorian Mental Hlth Lib, Parkville, Vic 3050, Australia.
[Hoffmann, Robert] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
[Barash, Carol Isaacson] Eth & Policy Consulting Inc, Genet, Boston, MA USA.
[Kojima, Toshio; Utsunomiya, Joji] RIKEN, Adv Computat Sci Dept, Kanagawa, Japan.
[Laradi, Sandrine] Estab Francais Du Sang, Auvergne Loire, France.
[Lee, Yeon-Su] Natl Canc Ctr, Funct Genom Branch, Goyang, South Korea.
[Gil-da-Silva-Lopes, Vera L.] Univ Estadual Campinas, Dept Med Genet, Campinas, Brazil.
[Macrae, Finlay A.] Royal Melbourne Hosp, Dept Colorectal Med & Genet, Melbourne, Vic, Australia.
[Maglott, Donna] NCBI, OMIM, Baltimore, MD USA.
[Marsh, Steven G. E.] UCL, Inst Canc, Dept Haematol, London, England.
[Marsh, Steven G. E.] Anthony Nolan Res Inst, HLA Informat Grp, London, England.
[Marafie, Makia J.] Kuwait Med Gent Ctr, Kuwait, Kuwait.
[Matsubara, Yoichi] Tohoku Univ, Sch Med, Dept Med Genet, Sendai, Miyagi 980, Japan.
[Messiaen, Ludwine M.] Univ Alabama, Dept Genet, Birmingham, AL USA.
[Moeslein, Gabriela] St Josefs Hosp Bochum Linden, Bochum, Germany.
[Netea, Mihai G.] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands.
[Oefner, Peter J.] Univ Regensburg, Inst Funct Genom, D-8400 Regensburg, Germany.
[Oetting, William S.] Univ Minnesota, Inst Human Genet, Dept Med, Minneapolis, MN 55455 USA.
[O'Leary, James C.] Genet Alliance, Washington, DC USA.
[Oller de Ramirez, Ana Maria] Natl Univ Cordoba, Sch Med, Pediat Clin Dept, Cordoba, Argentina.
[Patrinos, George P.] Erasmus Univ, Med Ctr, Fac Med & Hlth Sci, Dept Cell Biol & Genet,MGC, Rotterdam, Netherlands.
[Patrinos, George P.] Univ Patras, Dept Pharm, Patras, Greece.
[Paalman, Mark H.] Human Mutat, Hoboken, NJ USA.
[Parboosingh, Jillian] Univ Calgary, Calgary, AB T2N 1N4, Canada.
[Perozzi, Giuditta] Natl Res Inst Food & Nutr, INRAN, Rome, Italy.
[Phillips, Ian R.] Univ London, Sch Biol & Chem Sci, London WC1E 7HU, England.
[Prasad, Suyash] Genzyme Therapeut Ltd, Oxford, England.
[Qi, Ming] Zhejiang Univ, Sch Med, Affiliated Hosp 1, ADINOVO Ctr Genet & Genom Med, Hangzhou 310003, Zhejiang, Peoples R China.
[Qi, Ming] Univ Rochester, Med Ctr, New York, NY USA.
[Quin, David J.] Funding Hlth Informat Policy, Dept Human Serv, Melbourne, Vic, Australia.
[Ramesar, Rajkumar S.] Univ Cape Town, Natl Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa.
[Richards, C. Sue] Oregon Hlth & Sci Univ, DNA Diagnost Lab, Portland, OR 97201 USA.
[Savige, Judith] Univ Melbourne, Dept Med, Epping, NSW, Australia.
[Scheible, Dagmar G.] Klin Kinder & Jugendmed, Metab Dept, Reutlingen, Germany.
[Scott, Rodney J.] Univ Newcastle, Fac Hlth, Discipline Med Genet, Callaghan, NSW 2308, Australia.
[Seminara, Daniela] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
[Shephard, Elizabeth A.] UCL, Dept Biol Mol & Struct, London WC1E 6BT, England.
[Sijmons, Rolf H.] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands.
[Sobrido, Maria-Jesus] Inst Hlth Carlos III, Comp Network Biomed Res Rare Dis, Madrid, Spain.
[Sobrido, Maria-Jesus] Fdn Publ Galega Med Xenom, Santiago De Compostela, Spain.
[Tanaka, Toshihiro] RIKEN, Ctr Genom Med, Tokyo, Japan.
[Tavtigian, Sean V.] IARC, Lyon, France.
[Taylor, Graham R.] UK Mutat Detect Facil, Reg DNA Lab, Leeds, W Yorkshire, England.
[Teague, Jon] Wellcome Trust Sanger Inst, Canc Genom Project, Hinxton, England.
[Toepel, Thoralf] Univ Bielefeld, Bioinformat Dept, Tech Facil, D-4800 Bielefeld, Germany.
[Ullman-Cullere, Mollie] Harvard Univ, Sch Med, Partners HealthCare Ctr Genet & Genom, Cambridge, MA 02138 USA.
[van Kranen, Henk J.] Natl Inst Publ Hlth & Environm, Utrecht, Netherlands.
[Vihinen, Mauno] Univ Tampere, Inst Med Technol, Bioinformat Grp, FIN-33101 Tampere, Finland.
[Vihinen, Mauno] Tampere Univ Hosp, Tampere, Finland.
[Weber, Thomas K.] Albert Einstein Coll Med, Dept Surg, New York, NY USA.
[Weber, Thomas K.] Albert Einstein Coll Med, Dept Mol Genet, New York, NY USA.
[Yeager, Meredith] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Yeom, Young I.] Korea Res Inst Biosci & Biotechnol, Med Genom Res Ctr, Taejon, South Korea.
[Yoo, Hyang-Sook] KRIBB, Fred Hutchinson Canc Res Ctr, Ctr Collaborat, Taejon, South Korea.
RP Kaput, J (reprint author), US FDA, Natl Ctr Toxicol Res, Div Personalized Nutr & Med, 3900 NCTR Rd, Jefferson, AR 72079 USA.
EM James.kaput@fda.hhs.gov
RI Bustamante, Mariona/M-7277-2015; Oefner, Peter/K-1116-2016; Brenner,
Steven/A-8729-2008; Alonso, Santos/L-8316-2014; Perozzi,
Giuditta/A-7460-2016; Ramesar, Raj/I-6941-2015; Netea,
Mihai/N-5155-2014; Phillips, Ian/A-7337-2008; Aretz, Stefan/C-1241-2008;
Hardison, Ross/G-1142-2010; Dalgleish, Raymond/A-2893-2008; Hancock,
John/A-2442-2009; Vihinen, Mauno/A-8452-2012; Sijmons, Rolf/E-5829-2012;
LABO, U827/A-8632-2008; Bapat, Bharati/B-5839-2014; Golubenko,
Maria/A-8107-2014; Al-Mulla, Fahd/E-2068-2015
OI Burn, John/0000-0002-9823-2322; Savige, Judy/0000-0002-6813-0288;
Bustamante, Mariona/0000-0003-0127-2860; Oefner,
Peter/0000-0002-1499-3977; Brenner, Steven/0000-0001-7559-6185; Smith,
Timothy/0000-0001-9068-4642; Alonso, Santos/0000-0003-0221-4048;
Auerbach, Arleen/0000-0002-6911-8379; Perozzi,
Giuditta/0000-0003-1755-6104; Flicek, Paul/0000-0002-3897-7955; Ramesar,
Raj/0000-0001-5688-1634; Aretz, Stefan/0000-0002-5228-1890; Hardison,
Ross/0000-0003-4084-7516; Dalgleish, Raymond/0000-0001-7667-187X;
Hancock, John/0000-0003-2991-2217; Vihinen, Mauno/0000-0002-9614-7976;
Sijmons, Rolf/0000-0001-8446-2779; Golubenko, Maria/0000-0002-7692-9954;
Al-Mulla, Fahd/0000-0001-5409-3829
FU Medical Research Council [MC_U142684171]; NHGRI NIH HHS [RC2 HG005573];
NIDDK NIH HHS [R01 DK065806]
NR 105
TC 33
Z9 36
U1 0
U2 21
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD APR
PY 2009
VL 30
IS 4
BP 496
EP 510
DI 10.1002/humu.20972
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 430RO
UT WOS:000265006400002
PM 19306394
ER
PT J
AU Herman, ML
Farasat, S
Steinbach, PJ
Wei, MH
Toure, O
Fleckman, P
Blake, P
Bale, SJ
Toro, JR
AF Herman, Matthew L.
Farasat, Sharifeh
Steinbach, Peter J.
Wei, Ming-Hui
Toure, Ousmane
Fleckman, Philip
Blake, Patrick
Bale, Sherri J.
Toro, Jorge R.
TI Transglutaminase-1 Gene Mutations in Autosomal Recessive Congenital
Ichthyosis: Summary of Mutations (Including 23 Novel) and Modeling of
TGase-1
SO HUMAN MUTATION
LA English
DT Review
DE autosomal recessive congenital ichthyosis; ARCI; TGM1 gene; TGAse-1;
molecular modeling; mutation update
ID CORNIFIED CELL-ENVELOPE; BATHING-SUIT ICHTHYOSIS; CROSS-LINKED ENVELOPE;
HUMAN EPIDERMAL-KERATINOCYTES; HEALING COLLODION BABY; LAMELLAR
ICHTHYOSIS; TERMINAL DIFFERENTIATION; HARLEQUIN ICHTHYOSIS; DNA
METHYLATION; TRANSPORTER ABCA12
AB Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of rare cornification diseases. Germline mutations in TGM1 are the most common cause of ARCI in the United States. TGM1 encodes for the TGase-1 enzyme that functions in the formation of the cornified cell envelope. Structurally defective or attenuated cornified cell envelop have been shown in epidermal scales and appendages of ARCI patients with TGM1 mutations. We review the clinical manifestations as well as the molecular genetics of ARCI In addition, we characterized 115 TGM1 mutations reported in 234 patients from diverse racial and ethnic backgrounds (Caucasion Americans, Norwegians, Swedish, Finnish, German, Swiss, French, Italian, Dutch, Portuguese, Hispanics, Iranian, Tunisian, Moroccan, Egyptian, Afghani, Hungarian, African Americans, Korean, Japanese and South African). We report 23 novel mutations: 71 (62%) missense; 20 (17%) nonsense; 9 (8%) deletion; 8 (7%) splice-site,and 7 (6%) insertion. The c.877-2A>G was the most commonly reported TGM1 mutation accounting for 34% (147 of 435) of all TGM1 mutant alleles reported to date. It had been shown that this mutation is common among North American and Norwegian patients due to a founder effect. Thirty-one percent (36 of 115) of all mutations and 41% (29 of 71) of missense mutations occurred in arginine residues in TGase-1. Forty-nine percent (35 of 71) of missense mutations were within CpG dinucleotides, and 74% (26/35) of these mutations were C > Tor G >A transitions. We constructed a model of human TGase-1 and showed that all mutated arginines that reside in the two beta-barrel domains and two (R142 and R143) in the beta,sandwich are located at domain interfaces. In conclusion, this study expands the TGM1 mutation spectrum and summarizes the current knowledge of TGM1 mutations. The high frequency of mutated arginine codons in TGM1 may be due to the deamination of 5' methylated CpG dinucleotides. Hum Mutat 30, 537-547, 2009. Published 2008 Wiley-Liss, Inc.
C1 [Toro, Jorge R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA.
[Steinbach, Peter J.] NIH, Ctr Mol Modeling, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
[Wei, Ming-Hui] SAIC Frederick Inc, Basic Res Program, Frederick, MD USA.
[Fleckman, Philip] Univ Washington, Dept Med, Div Dermatol, Seattle, WA USA.
[Blake, Patrick] Howard Hughes Med Inst, Chevy Chase, MD USA.
[Bale, Sherri J.] GeneDx Inc, Gaithersburg, MD USA.
RP Toro, JR (reprint author), NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,Execut Plaza S,Room 7012, Rockville, MD 20892 USA.
EM toroj@mail.nih.gov
FU DCEG; NCI; NIH
FX Grant sponsors: the Intramural Research Program of DCEG, NCI, NIH.
NR 111
TC 38
Z9 42
U1 0
U2 5
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD APR
PY 2009
VL 30
IS 4
BP 537
EP 547
DI 10.1002/humu.20952
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 430RO
UT WOS:000265006400006
PM 19241467
ER
PT J
AU Choi, BY
Stewart, AK
Madeo, AC
Pryor, SP
Lenhard, S
Kittles, R
Eisenman, D
Kim, HJ
Niparko, J
Thomsen, J
Arnos, KS
Nance, WE
King, KA
Zalewski, CK
Brewer, CC
Shawker, T
Reynolds, JC
Butman, JA
Karniski, LP
Alper, SL
Griffith, AJ
AF Choi, Byung Yoon
Stewart, Andrew K.
Madeo, Anne C.
Pryor, Shannon P.
Lenhard, Suzanne
Kittles, Rick
Eisenman, David
Kim, H. Jeffrey
Niparko, John
Thomsen, James
Arnos, Kathleen S.
Nance, Walter E.
King, Kelly A.
Zalewski, Christopher K.
Brewer, Carmen C.
Shawker, Thomas
Reynolds, James C.
Butman, John A.
Karniski, Lawrence P.
Alper, Seth L.
Griffith, Andrew J.
TI Hypo-Functional SLC26A4 Variants Associated with Nonsyndromic Hearing
Loss and Enlargement of the Vestibular Aqueduct: Genotype-Phenotype
Correlation or Coincidental Polymorphisms?
SO HUMAN MUTATION
LA English
DT Article
DE enlargement of the vestibular aqueduct; EVA; deafness; DFNB4; hearing;
genotype-phenotype correlation; PDS; pendrin; SLC26A4
ID TRANSPORTER DTDST GENE; PENDRED-SYNDROME; PDS GENE; CONGENITAL
HYPOTHYROIDISM; ENDOPLASMIC-RETICULUM; MOLECULAR ANALYSIS; MOUSE MODEL;
2 FAMILIES; MUTATIONS; DEAFNESS
AB Hearing, loss with enlargement of the vestibular aqueduct (EVA) can be associated with mutations of the SLC26A4 gene encoding pendrin, a transmembrane Cl(-)/I(-)/HCO(3)(-) exchanger. Pendrin's critical transport substrates are thought to be I(-) in the thyroid gland and HCO(3)(-) in the inner ear. We previously reported that bi-allelic SLC26A4 mutations are associated with Pendred syndromic EVA whereas one or zero mutant alleles are associated with nonsyndromic EVA. One study proposed a correlation of nonsyndromic EVA with SLC26A4 alleles encoding pendrin with residual transport activity. Here we describe the phenotypes and SLC26A4 genotypes of 47 EVA patients ascertained since our first report of 39 patients. We sought to determine the pathogenic potential of each variant in our full cohort of 86 patients. We evaluated the trafficking of I I missense pendrin products expressed in COS-7 cells. Products that targeted to the plasma membrane were expressed in Xenopus oocytes for measurement of anion exchange activity. p.F335L, p.C565Y, p.L597S, p.M775T, and p.R776C had Cl(-)/I(-) and Cl(-)/HCO(3)(-) exchange rate constants that ranged from 13 to 93% of wild type values. p.F335L, p.L597S, p.M775T and p.R776C are typically found as mono-allelic variants in nonsyndromic EVA. The high normal control carrier rate for p.L597S indicates it is a coincidentally detected nonpathogenic variant in this context. We observed moderate differential effects of hypo-functional variants upon exchange of HCO(3)(-) versus I(-) but their magnitude does not support a causal association with nonsyndromic EVA. However, these alleles could be pathogenic in trans configuration with a mutant allele in Pendred syndrome. Hum Mutat 30, 599-608, 2009. (C) 2009 Wiley,Liss, Inc.
C1 [Madeo, Anne C.; Pryor, Shannon P.; Kim, H. Jeffrey; King, Kelly A.; Zalewski, Christopher K.; Brewer, Carmen C.; Griffith, Andrew J.] NIDCD, Otolaryngol Branch, NIH, Rockville, MD 20850 USA.
[Choi, Byung Yoon] NIDCD, Mol Genet Lab, NIH, Rockville, MD 20850 USA.
[Stewart, Andrew K.; Alper, Seth L.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
[Kittles, Rick] Univ Chicago, Pritzker Sch Med, Dept Med, Chicago, IL 60637 USA.
[Eisenman, David] Univ Maryland, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Baltimore, MD 21201 USA.
[Kim, H. Jeffrey] Georgetown Univ Hosp, Dept Otolaryngol Head & Neck Surg, Washington, DC 20007 USA.
[Niparko, John] Johns Hopkins Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA.
[Thomsen, James] Pediat Ear Nose & Throat Atlanta, Atlanta, GA USA.
[Arnos, Kathleen S.] Gallaudet Univ, Dept Biol, Washington, DC 20002 USA.
[Nance, Walter E.] Virginia Commonwealth Univ, Med Coll Virginia, Dept Human Genet, Richmond, VA 23298 USA.
[King, Kelly A.] Univ Maryland, Hearing & Speech Sci Dept, College Pk, MD 20742 USA.
[Shawker, Thomas; Butman, John A.] NIH, Warren G Magnuson Clin Ctr, Dept Diagnost Radiol, Bethesda, MD 20892 USA.
[Reynolds, James C.] NIH, Warren G Magnuson Clin Ctr, Dept Nucl Med, Bethesda, MD 20892 USA.
[Karniski, Lawrence P.] Vet Affairs Med Ctr, Dept Internal Med, Iowa City, IA 52242 USA.
[Karniski, Lawrence P.] Univ Iowa, Coll Med, Iowa City, IA USA.
RP Griffith, AJ (reprint author), NIDCD, Otolaryngol Branch, NIH, 5 Res Court,Room 1A-13D, Rockville, MD 20850 USA.
EM griffita@nidcd.nih.gov
RI Butman, John/A-2694-2008; Madeo, Anne/K-2880-2012; Butman,
John/J-2780-2013
OI Butman, John/0000-0002-1547-9195
FU Intramural NIH HHS; NIDCD NIH HHS [Z01 DC000060, Z01 DC000064]; NIDDK
NIH HHS [DK34854, DK43495, P30 DK034854, R37 DK043495, R37 DK043495-17]
NR 53
TC 80
Z9 89
U1 2
U2 5
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD APR
PY 2009
VL 30
IS 4
BP 599
EP 608
DI 10.1002/humu.20884
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 430RO
UT WOS:000265006400013
PM 19204907
ER
PT J
AU Roessler, E
Lacbawan, F
Dubourg, C
Paulussen, A
Herbergs, J
Hehr, U
Bendavid, C
Zhou, N
Ouspenskaia, M
Bale, S
Odent, S
David, V
Muenke, M
AF Roessler, Erich
Lacbawan, Felicitas
Dubourg, Christele
Paulussen, Aimee
Herbergs, Jos
Hehr, Ute
Bendavid, Claude
Zhou, Nan
Ouspenskaia, Maia
Bale, Sherri
Odent, Sylvie
David, Veronique
Muenke, Maximilian
TI The Full Spectrum of Holoprosencephaly-Associated Mutations within the
ZIC2 Gene in Humans Predicts Loss-of-Function as the Predominant Disease
Mechanism
SO HUMAN MUTATION
LA English
DT Article
DE holoprosencephaly; mutation spectrum; ZIC2
ID PROTEIN; IDENTIFICATION; EXPRESSION; FOREBRAIN; DEFECTS; SIX3; SHH
AB Mutations of the ZIC2 transcription factor gene are among the most common heterozygous variations detected in holoprosencephaly (HPE) patients, a patient group who lack critical midline forebrain specification due to defective embryonic signaling during development. Recent studies indicate that complete deficiency of the related murine Zic2 transcription factor can also be a contributing factor to variable midline deficiencies, presenting during mid-gastrulation, that could explain similar forebrain anomalies in this model system. Here we collect and summarize all available mutations in the human ZIC2 gene detected in HPE patients (21 published and 62 novel). Our analysis corroborates this mechanism proposed in mice by predicting loss-of-function as the likely pathogenetic mechanism common to most, if not all, of these mutations in HPE. (C) 2009 Wiley-Liss, Inc.
C1 [Roessler, Erich; Lacbawan, Felicitas; Zhou, Nan; Ouspenskaia, Maia; Muenke, Maximilian] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
[Dubourg, Christele; Bendavid, Claude; David, Veronique] CHU Pontchaillou, Genet Mol Lab, Rennes, France.
[Dubourg, Christele; Bendavid, Claude; Odent, Sylvie; David, Veronique] Univ Rennes 1, CNRS, Genet & Dev UMR6061, IFR 140, Rennes, France.
[Paulussen, Aimee; Herbergs, Jos] Acad Hosp Maastricht azM, Dept Clin Genet, Maastricht, Netherlands.
[Hehr, Ute] Univ Gottingen, Inst Human Genet, Dept Pediat, D-3400 Gottingen, Germany.
[Hehr, Ute] Univ Gottingen, Inst Human Genet, Dept Pediat Neurol, D-3400 Gottingen, Germany.
[Bale, Sherri] GeneDx, Gaithersburg, MD USA.
[Odent, Sylvie] CHU Hop Sud, Serv Genet Clin, Rennes, France.
RP Muenke, M (reprint author), NHGRI, Med Genet Branch, NIH, 35 Convent Dr,MSC 3717,Bldg 35,Room 1B-203, Bethesda, MD 20892 USA.
EM mmuenke@nhgri.nih.gov
FU Division of Intramural Research of the National Human Genome Research
Institute, National Institutes of Health; GIS Intitut des Maladies
Rares, COREC (CHU, Faculte de Medecine, Rennes, France)
FX The authors wish to thank the patients who participated in this research
and the many clinicians who referred them. This research was supported
by the Division of Intramural Research of the National Human Genome
Research Institute, National Institutes of Health, and by the GIS
Intitut des Maladies Rares, COREC (CHU, Faculte de Medecine, Rennes,
France).
NR 34
TC 37
Z9 38
U1 0
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD APR
PY 2009
VL 30
IS 4
BP E541
EP E553
DI 10.1002/humu.20982
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 626PU
UT WOS:000279979700001
PM 19177455
ER
PT J
AU Vugrek, O
Beluzic, R
Nakic, N
Mudd, SH
AF Vugrek, Oliver
Beluzic, Robert
Nakic, Nikolina
Mudd, S. Harvey
TI S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency: Two Novel Mutations
with Lethal Outcome
SO HUMAN MUTATION
LA English
DT Article
DE AHCY; intermolecular disulphide bond; NADH; genotype-phenotype
ID SITE-DIRECTED MUTAGENESIS; ADENOSYL-L-HOMOCYSTEINE; RAT-LIVER; CATALYTIC
MECHANISM; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; SINGLE MUTATION; ENZYME;
PROTEINS; BINDING
AB This paper reports studies of two novel, allelic missense mutations found in the S-adenosylhomocysteine hydrolase (AHCY) gene from a new case of AHCY deficiency in an infant girl who died at age four months. The mutations lead to replacement of arginine with cysteine (p.Arg49Cys) and aspartic acid with glycine (p.Asp86Gly). Functional analysis of recombinant proteins containing the mutations detected showed that both dramatically reduce AHCY activity. The p.Arg49Cys mutant protein forms intermolecular disulphide bonds, leading to macromolecular structures that can be prevented by reducing agent DTT. The p.Asp86Gly protein tends to form enzymatically inactive aggregates and the loss of a single negative charge as a result of the mutation is involved in enzyme inactivation. We show that replacing Gly86 with negatively charged Glu86 in mutant protein restores enzymatic activity to 70% of wild-type, whereas changing Gly86 to positively charged Lys86 or uncharged Leu86 does not improve enzyme activity, indicating that the negative charge is important for maintenance of such activity. These studies significantly extend knowledge about the importance of residue 86 for AHCY activity. Residue 86 has not been implicated before in this way and the results suggest that the present model of S- adenosylhomocysteine (AdoHcy) hydrolysis may need refinement. Our functional studies provide novel insight into the molecular defect underlying AHCY deficiency and reveal that both low enzyme activity and protein stability of AHCY contribute to the clinical phenotype. (C) 2009 Wiley-Liss, Inc.
C1 [Vugrek, Oliver; Beluzic, Robert; Nakic, Nikolina] Inst Ruder Boskovic, Div Mol Med, Zagreb 10000, Croatia.
[Mudd, S. Harvey] NIMH, Mol Biol Lab, Bethesda, MD 20892 USA.
RP Vugrek, O (reprint author), Inst Ruder Boskovic, Div Mol Med, Bijenicka 54, Zagreb 10000, Croatia.
EM ovugrek@irb.hr
FU Ministry of Science, Education and Sports from the Republic of Croatia
[0098086, 098-0000000-2463]
FX This work was supported by grants 0098086 and 098-0000000-2463 (OV) of
the Ministry of Science, Education and Sports from the Republic of
Croatia. Special thanks go to Igor Jurak for critical reading and
helpful comments.
NR 20
TC 11
Z9 12
U1 0
U2 9
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD APR
PY 2009
VL 30
IS 4
BP E555
EP E565
DI 10.1002/humu.20985
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 626PU
UT WOS:000279979700002
PM 19177456
ER
PT J
AU Gualco, G
Queiroga, EM
Weiss, LM
Klumb, CEN
Harrington, WJ
Bacchi, CE
AF Gualco, Gabriela
Queiroga, Eduardo M.
Weiss, Lawrence M.
Klumb, Claudete E. N.
Harrington, William J., Jr.
Bacchi, Carlos E.
TI Frequent expression of multiple myeloma 1/interferon regulatory factor 4
in Burkitt lymphoma
SO HUMAN PATHOLOGY
LA English
DT Article
DE Burkitt lymphoma; MUM1/IRF4; TMA; Immunohistochemistry; EBV;
Transcription factor
ID B-CELL LYMPHOMA; EPSTEIN-BARR-VIRUS; GERMINAL CENTER; TRANSCRIPTION
FACTORS; HODGKIN-LYMPHOMA; MUM1/IRF4; BRAZIL; IMMUNOHISTOCHEMISTRY;
DIAGNOSIS; HISTOGENESIS
AB Burkitt lymphoma is a highly aggressive non-Hodgkin lymphoma with endemic, sporadic, and immunodeficiency-associated clinical variants composed of monomorphic medium-sized B cells with a high proliferation rate and a translocation involving the C-MYC locus. Classically, the immunophenotype of Burkitt lymphoma has been considered to be the germinal center type. In most reports, all cases of Burkitt lymphoma are reported to be multiple myeloma 1-negative. multiple myeloma 1 expression is seen in plasma cells and in a small fraction of B cells located in the light zone of germinal centers corresponding to the final step of intra-germinal center B-cell differentiation, and in activated T cells. Therefore, multiple myeloma 1 expression may denote the final step of intra-germinal center B-cell differentiation at the centrocyte stage, as well as the subsequent steps of B-cell maturation toward plasma cells. Unlike most normal germinal center B cells, in which the expression of multiple myeloma 1 and bcl-6 are mutually exclusive, the tumor cells in approximately 50% of multiple myeloma 1-positive DLBCL show coexpression of bcl-6, suggesting that the expression of these proteins may be deregulated. Twenty-five Burkitt lymphoma cases, including 19 associated with HIV, were reported in one of the few studies in the literature; 2 of these cases showed occasional Multiple myeloma 1-positive cells, less than the 20% cutoff for positivity. We studied 222 cases of well-characterized Burkitt lymphoma with the classic phenotype and C-MYC translocation and found 90 cases (40.5%) with multiple myeloma 1 nuclear expression, Suggesting a late germinal center stage of differentiation. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Gualco, Gabriela; Queiroga, Eduardo M.; Bacchi, Carlos E.] Consultoria Patol, BR-18602010 Botucatu, SP, Brazil.
[Weiss, Lawrence M.] City Hope Natl Med Ctr, Div Pathol, Duarte, CA 91010 USA.
[Klumb, Claudete E. N.] Inst Nacl Canc, BR-20230130 Rio De Janeiro, Brazil.
[Harrington, William J., Jr.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
[Harrington, William J., Jr.] Fogarty Int Ctr AIDS & TB Program, Sylvester Canc Ctr, Miami, FL 33136 USA.
RP Bacchi, CE (reprint author), Consultoria Patol, BR-18602010 Botucatu, SP, Brazil.
EM bacchi@consultoriapatologia.com.br
RI Inca, Inct/K-2204-2013; Klumb, Claudete/L-2682-2015
OI Klumb, Claudete/0000-0002-7672-1088
FU NCI [5R01CA121935, 5R01CA112217, 5U01CA121947]
FX This Study was partially supported by NCI 5R01CA121935 (W.H.),
5R01CA112217 (W.H.), and the (NCI) AIDS Malignancy Consortium
(5U01CA121947).
NR 34
TC 13
Z9 17
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0046-8177
J9 HUM PATHOL
JI Hum. Pathol.
PD APR
PY 2009
VL 40
IS 4
BP 565
EP 571
DI 10.1016/j.humpath.2008.07.021
PG 7
WC Pathology
SC Pathology
GA 430LI
UT WOS:000264990200016
PM 19144381
ER
PT J
AU Dupont, C
Bavister, BD
Armant, DR
Brenner, CA
AF Dupont, Catherine
Bavister, Barry D.
Armant, D. Randall
Brenner, Carol A.
TI Rhesus macaque embryos derived from MI oocytes maturing after retrieval
display high rates of chromosomal anomalies
SO HUMAN REPRODUCTION
LA English
DT Article
DE aneuploidy; embryo; FISH; in vitro maturation; monkey
ID INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; INVITRO
FERTILIZATION; MATURATION; MONKEY; QUALITY; SPINDLE; ANEUPLOIDY;
CULTURE; ICSI
AB Rhesus macaque and human preimplantation embryos display similar rates of chromosomal abnormalities. The aim of this study was to determine whether embryos developing from MI oocytes that mature post-retrieval display more chromosomal anomalies than those embryos that are generated from oocytes that are at MII at the time of retrieval.
Rhesus macaque oocytes were obtained after hormonal ovarian stimulation. Immediately after retrieval, the oocytes were classified according to their maturational status. Following in vitro fertilization, Day 3 embryos with good morphology and development derived from oocytes maturing post-retrieval and those from oocytes that were mature at the time of retrieval were cytogenetically assessed using a five-color fluorescent in situ fluorescent hybridization assay developed for rhesus macaque chromosomes homologous to human chromosomes 13, 16, 18, X and Y.
Blastomeres from 53 embryos were analyzed. Of the 27 embryos that developed from oocytes that were mature at collection, 18 embryos were chromosomally normal (66.7%), while from the 26 embryos that developed from oocytes that matured post-retrieval, only 9 embryos were chromosomally normal (34.6%).
These results indicate that embryos developing from oocytes maturing post-retrieval display high rates of chromosomal abnormalities and have therefore a reduced developmental competence. As a result, the clinical relevance of using immature oocytes that are retrieved after stimulated cycles in human IVF warrants further investigation.
C1 [Dupont, Catherine; Brenner, Carol A.] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
[Dupont, Catherine; Bavister, Barry D.; Armant, D. Randall; Brenner, Carol A.] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
[Armant, D. Randall] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA.
[Bavister, Barry D.] Caribbean Primate Res Ctr, Sabana Seca, PR USA.
[Armant, D. Randall] NICHD, Program Reprod & Adult Endocrinol, NIH, DHHS, Bethesda, MD USA.
RP Dupont, C (reprint author), Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
EM cdupont@med.wayne.edu
OI Armant, D. Randall/0000-0001-5904-9325
FU National Institutes of Health [HD045966, RR015395, HD046553, RR021881];
Intramural Research Program of the Eunice Kennedy Shriver; National
Institute of Child Health and Human Development; National Institutes of
Health; DHHS
FX This study was supported by the National Institutes of Health (HD045966
and RR015395 to B. D. B.; HD046553 and RR021881 to C. A. B.) and by the
Intramural Research Program of the Eunice Kennedy Shriver, National
Institute of Child Health and Human Development, National Institutes of
Health, DHHS.
NR 45
TC 8
Z9 8
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
J9 HUM REPROD
JI Hum. Reprod.
PD APR
PY 2009
VL 24
IS 4
BP 929
EP 935
DI 10.1093/humrep/den429
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 421XO
UT WOS:000264391800024
PM 19106174
ER
PT J
AU Muntner, P
Krousel-Wood, M
Hyre, AD
Stanley, E
Cushman, WC
Cutler, JA
Piller, LB
Goforth, GA
Whelton, PK
AF Muntner, Paul
Krousel-Wood, Marie
Hyre, Amanda D.
Stanley, Erin
Cushman, William C.
Cutler, Jeffrey A.
Piller, Linda B.
Goforth, Gary A.
Whelton, Paul K.
TI Antihypertensive Prescriptions for Newly Treated Patients Before and
After the Main Antihypertensive and Lipid-Lowering Treatment to Prevent
Heart Attack Trial Results and Seventh Report of the Joint National
Committee on Prevention, Detection, Evaluation, and Treatment of High
Blood Pressure Guidelines
SO HYPERTENSION
LA English
DT Article
DE hypertension; antihypertensive agents; thiazide diuretics; clinical
trials; epidemiology
ID CONVERTING ENZYME-INHIBITOR; CALCIUM-CHANNEL BLOCKER; ANTI HYPERTENSIVE
DRUGS; ALPHA-BLOCKER; UNITED-STATES; END-POINT; ALLHAT; PHYSICIANS;
OUTCOMES; HEALTH
AB Main results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial were published in December 2002. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, published in May 2003, recommended thiazide-type diuretics as initial pharmacological treatment alone or in combination with another drug in most patients with hypertension. To assess changes from before to after these publications, we compared antihypertensive medication prescriptions filled by patients who initiated pharmacological antihypertensive treatment in a large managed care organization during 3 time periods: (1) July 1, 2001, to June 30, 2002 (before these publications; n=1354); (2) July 1, 2003, to June 30, 2004 (to assess short-term changes; n=1542); and (3) July 1, 2004, to June 30, 2005 (to assess extended changes; n=1865). The percentage of patients initiating antihypertensive treatment with a thiazide-type diuretic increased from 30.6% to 39.4% (P < 0.001) between 2001-2002 and 2003-2004, and the increase was maintained at 36.5% in 2004-2005 (P < 0.001 compared with 2001-2002 and P=0.33 compared with 2003-2004). Among patients without diabetes mellitus, renal disease, a history of myocardial infarction, or heart failure, the percentage initiating pharmacological antihypertensive treatment with a thiazide-type diuretic increased from 33.1% in 2001-2002 to 43.4% in 2003-2004 (P < 0.001) and remained increased (41.0%) in 2004-2005 (P < 0.001 and P=0.23 compared with 2001-2002 and 2003-2004, respectively). Despite a sustained increase in the use of thiazide-type diuretics, this study indicates that an opportunity exists to increase adherence to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure guidelines. (Hypertension. 2009;53:617-623.)
C1 [Muntner, Paul] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY 10016 USA.
[Krousel-Wood, Marie; Stanley, Erin] Alton Ochsner Med Fdn & Ochsner Clin, New Orleans, LA 70121 USA.
[Krousel-Wood, Marie; Stanley, Erin] Tulane Univ, Sch Med, New Orleans, LA 70112 USA.
[Krousel-Wood, Marie; Stanley, Erin] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA.
[Hyre, Amanda D.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
[Cushman, William C.] Memphis Vet Affairs Med Ctr, Memphis, TN USA.
[Cutler, Jeffrey A.] NHLBI, Bethesda, MD 20892 USA.
[Piller, Linda B.] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Houston, TX USA.
[Goforth, Gary A.] Montgomery Ctr Family Med, Greenwood, SC USA.
[Whelton, Paul K.] Loyola Univ, Med Ctr, Maywood, IL 60153 USA.
RP Muntner, P (reprint author), Mt Sinai Sch Med, Dept Community & Prevent Med, 1Gustave L Levy Pl, New York, NY 10016 USA.
EM paul.muntner@mssm.edu
RI Krousel-Wood, Marie Antoinette/D-4718-2011
FU National Heart, Lung, and Blood Institute; Pfizer, Inc
FX The ALLHAT Study was supported by a contract with the National Heart,
Lung, and Blood Institute. The ALLHAT investigators acknowledge
contributions of study medications supplied by Pfizer, Inc (amlodipine
and doxazosin), AstraZeneca (atenolol and lisinopril), and Bristol-Myers
Squibb (pravastatin), as well as financial support provided by Pfizer,
Inc.
NR 25
TC 31
Z9 32
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2009
VL 53
IS 4
BP 617
EP 623
DI 10.1161/HYPERTENSIONAHA.108.120154
PG 7
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 421EH
UT WOS:000264341400012
PM 19221214
ER
PT J
AU Wang, SM
Duyn, JH
AF Wang, Shumin
Duyn, Jeff H.
TI Three-Dimensional Automatic Mesh Generation for Hybrid Electromagnetic
Simulations
SO IEEE ANTENNAS AND PROPAGATION MAGAZINE
LA English
DT Article
DE Mesh generation; finite element methods; finite difference methods;
time-domain analysis; matrix inversion; FDTD methods; radar cross
sections; head; magnetic resonance imaging
ID ADVANCING FRONT TECHNIQUE; FINITE-DIFFERENCE; TETRAHEDRAL MESHES;
ELEMENT; OPTIMIZATION; IMPROVEMENT; ALGORITHM
AB Hybrid mesh generation is required for Finite-Difference Time-Domain/Finite-Element Time-Domain (FDTD/FETD) hybrid simulations. A combined approach is presented to automatically generate Cartesian/tetrahedral hybrid meshes for open and closed structures. This approach first generates a buffer zone that surrounds a target with specified tightness. The advancing-front technique with "sweep-and-retry" is subsequently applied to generate an initial tetrahedral mesh that fills the buffer zone. Finally, the tetrahedral mesh undergoes a combined quality improvement procedure. Due to the low profile of the resulting tetrahedral mesh, the sparse Cholesky decomposition can be applied effectively to solve the resulting FETD matrix. Several examples are provided to demonstrate the main features and the performance of the proposed automatic mesh-generation method.
C1 [Wang, Shumin; Duyn, Jeff H.] NCI, Lab Funct & Mol Imaging, NINDS, Bethesda, MD 20892 USA.
RP Wang, SM (reprint author), NCI, Lab Funct & Mol Imaging, NINDS, 10 Ctr Dr 10-B1D728, Bethesda, MD 20892 USA.
EM james.wang@ieee.org
RI Duyn, Jozef/F-2483-2010
FU National Institute of Neurological Disorders and Stroke
FX The authors gratefully acknowledge Dr. Alan P. Koretsky for helpful
discussions. This work was sponsored by the intramural research program
of the National Institute of Neurological Disorders and Stroke.
NR 31
TC 2
Z9 2
U1 1
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1045-9243
EI 1558-4143
J9 IEEE ANTENN PROPAG M
JI IEEE Antennas Propag. Mag.
PD APR
PY 2009
VL 51
IS 2
BP 71
EP 85
DI 10.1109/MAP.2009.5162020
PG 15
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 462FN
UT WOS:000267335300008
ER
PT J
AU Wang, SM
Murphy-Boesch, J
Merkle, H
Koretsky, AP
Duyn, JH
AF Wang, Shumin
Murphy-Boesch, Joseph
Merkle, Hellmut
Koretsky, Alan P.
Duyn, Jeff H.
TI B-1 Homogenization in MRI by Multilayer Coupled Coils
SO IEEE TRANSACTIONS ON MEDICAL IMAGING
LA English
DT Article
DE Magnetic resonance imaging (MRI); radio frequency coils
ID FIELD INHOMOGENEITY; RADIOFREQUENCY COIL; TRANSMIT SENSE; RF COILS;
DESIGN
AB Transmit B-1(+) field homogenization in high-field (>3.0 T) human magnetic resonance imaging (MRI) is challenging due to radio-frequency wavelength effects. An approach based on appropriately coupling surface coils to a volume coil was investigated. Electromagnetic simulation results demonstrated the feasibility and effectiveness of this method in proton MRI of the human head at 7.0 T.
C1 [Wang, Shumin; Murphy-Boesch, Joseph; Merkle, Hellmut; Koretsky, Alan P.; Duyn, Jeff H.] NINDS, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA.
RP Wang, SM (reprint author), NINDS, Lab Funct & Mol Imaging, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM wangshu@ninds.nih.gov
RI Duyn, Jozef/F-2483-2010; Koretsky, Alan/C-7940-2015
OI Koretsky, Alan/0000-0002-8085-4756
FU Intramural NIH HHS [Z01 NS002989-08]
NR 18
TC 12
Z9 12
U1 1
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0278-0062
J9 IEEE T MED IMAGING
JI IEEE Trans. Med. Imaging
PD APR
PY 2009
VL 28
IS 4
BP 551
EP 554
DI 10.1109/TMI.2008.2006523
PG 4
WC Computer Science, Interdisciplinary Applications; Engineering,
Biomedical; Engineering, Electrical & Electronic; Imaging Science &
Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Computer Science; Engineering; Imaging Science & Photographic
Technology; Radiology, Nuclear Medicine & Medical Imaging
GA 431UR
UT WOS:000265090200007
PM 19336276
ER
PT J
AU Liu, JM
Udupa, JK
AF Liu, Jiamin
Udupa, Jayaram K.
TI Oriented Active Shape Models
SO IEEE TRANSACTIONS ON MEDICAL IMAGING
LA English
DT Article
DE Active shape models (ASMs); dynamic programming; image-based
segmentation; live wire; model-based segmentation
ID POINT DISTRIBUTION MODELS; IMAGE SEGMENTATION; DEFORMABLE CONTOURS;
APPEARANCE MODELS; LEFT-VENTRICLE; LIVE WIRE; SNAKES
AB Active shape models (ASM) are widely employed for recognizing anatomic structures and for delineating them in medical images. In this paper, a novel strategy called oriented active shape models (OASM) is presented in an attempt to overcome the following five limitations of ASM: 1) lower delineation accuracy, 2) the requirement of a large number of landmarks, 3) sensitivity to search range, 4) sensitivity to initialization, and 5) inability to fully exploit the specific information present in the given image to be segmented. OASM effectively combines the rich statistical shape information embodied in ASM with the boundary orientedness property and the globally optimal delineation capability of the live wire methodology of boundary segmentation. The latter characteristics allow live wire to effectively separate an object boundary from other nonobject boundaries with similar properties especially when they come very close in the image domain. The approach leads to a two-level dynamic programming method, wherein the first level corresponds to boundary recognition and the second level corresponds to boundary delineation, and to an effective automatic initialization method. The method outputs a globally optimal boundary that agrees with the shape model if the recognition step is successful in bringing the model close to the boundary in the image. Extensive evaluation experiments have been conducted by utilizing 40 image (magnetic resonance and computed tomography) data sets in each of five different application areas for segmenting breast, liver, bones of the foot, and cervical vertebrae of the spine. Comparisons are made between OASM and ASM based on precision, accuracy, and efficiency of segmentation. Accuracy is assessed using both region-based false positive and false negative measures and boundary-based distance measures. The results indicate the following: 1) The accuracy of segmentation via OASM is considerably better than that of ASM; 2) The number of landmarks can be reduced by a factor of 3 in OASM over that in ASM; 3) OASM becomes largely independent of search range and initialization becomes automatic. All three benefits of OASM ensue mainly from the severe constraints brought in by the boundary-orientedness property of live wire and the globally optimal solution found by the 2-level dynamic programming algorithm.
C1 [Udupa, Jayaram K.] Univ Penn, Dept Radiol, Med Image Proc Grp, Philadelphia, PA 19104 USA.
[Liu, Jiamin] NIH, Virtual Endoscopy & Comp Aided Diag Lab, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA.
RP Udupa, JK (reprint author), Univ Penn, Dept Radiol, Med Image Proc Grp, Philadelphia, PA 19104 USA.
EM liujiamin@cc.nih.gov; jay@mail.med.upenn.edu
FU NIBIB NIH HHS [EB004395]
NR 48
TC 48
Z9 55
U1 5
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0278-0062
EI 1558-254X
J9 IEEE T MED IMAGING
JI IEEE Trans. Med. Imaging
PD APR
PY 2009
VL 28
IS 4
BP 571
EP 584
DI 10.1109/TMI.2008.2007820
PG 14
WC Computer Science, Interdisciplinary Applications; Engineering,
Biomedical; Engineering, Electrical & Electronic; Imaging Science &
Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Computer Science; Engineering; Imaging Science & Photographic
Technology; Radiology, Nuclear Medicine & Medical Imaging
GA 431UR
UT WOS:000265090200010
PM 19336277
ER
PT J
AU Ghosh, S
Navarathna, DHMLP
Roberts, DD
Cooper, JT
Atkin, AL
Petro, TM
Nickerson, KW
AF Ghosh, Suman
Navarathna, Dhammika H. M. L. P.
Roberts, David D.
Cooper, Jake T.
Atkin, Audrey L.
Petro, Thomas M.
Nickerson, Kenneth W.
TI Arginine-Induced Germ Tube Formation in Candida albicans Is Essential
for Escape from Murine Macrophage Line RAW 264.7
SO INFECTION AND IMMUNITY
LA English
DT Article
ID NITRIC-OXIDE PRODUCTION; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR;
UREA AMIDOLYASE; HELICOBACTER-PYLORI; FILAMENTOUS-GROWTH; GENE;
FARNESOL; INFECTION; FUNGI
AB The opportunistic fungal pathogen Candida albicans is a part of the normal flora but it also causes systemic candidiasis if it reaches the bloodstream. Upon being phagocytized by macrophages, an important component of innate immunity, C. albicans rapidly upregulates a set of arginine biosynthetic genes. Arginine, urea, and CO(2) induced hyphae in a density-dependent manner in wild-type, cph1/cph1, and rim101/rim101 strains but not in efg1/efg1 or cph1/cph1 efg1/efg1 strains. Arginase (Car1p) converts arginine to urea, which in turn is degraded by urea amidolyase (Dur1,2p) to produce CO(2), a signal for hyphal switching. We used a dur1,2/dur1,2 mutant (KWN6) and the complemented strain, KWN8 (dur1,2/dur1,2::DUR1,2/DUR1,2) to study germ tube formation. KWN6 could not make germ tubes in the presence of arginine or urea but did in the presence of 5% CO(2), which bypasses Dur1,2p. We also tested the effect of arginine on the interaction between the macrophage line RAW 264.7 and several strains of C. albicans. Arginine activated an Efg1p-dependent yeast-to-hypha switch, enabling wild-type C. albicans and KWN8 to escape from macrophages within 6 h, whereas KWN6 was defective in this regard. Additionally, two mutants that cannot synthesize arginine, BWP17 and SN152, were defective in making hyphae inside the macrophages, whereas the corresponding arginine prototrophs, DAY286 and SN87, formed germ tubes and escaped from macrophages. Therefore, metabolism of arginine by C. albicans controls hyphal switching and provides an important mechanism for escaping host defense.
C1 [Ghosh, Suman; Navarathna, Dhammika H. M. L. P.; Cooper, Jake T.; Atkin, Audrey L.; Nickerson, Kenneth W.] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA.
[Navarathna, Dhammika H. M. L. P.; Roberts, David D.] NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Petro, Thomas M.] Univ Nebraska Med Ctr, Dept Oral Biol, Lincoln, NE USA.
RP Nickerson, KW (reprint author), Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA.
EM knickerson1@unl.edu
RI Roberts, David/A-9699-2008; Ghosh, Suman/F-3453-2013
OI Roberts, David/0000-0002-2481-2981;
FU University of Nebraska Jessie Lee Fund; Tobacco Settlement Biomedical
Research Enhancement Fund; John C. and Nettie V. David Memorial Trust
Fund; Farnesol and Candida albicans Research Fund; University of
Nebraska Foundation; NIH; NCI; Center for Cancer Research.
FX This work was supported by the University of Nebraska Jessie Lee Fund,
Tobacco Settlement Biomedical Research Enhancement Fund, the John C. and
Nettie V. David Memorial Trust Fund, the Farnesol and Candida albicans
Research Fund, University of Nebraska Foundation, and the Intramural
Research Program of the NIH, NCI, Center for Cancer Research.
NR 40
TC 65
Z9 73
U1 1
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD APR
PY 2009
VL 77
IS 4
BP 1596
EP 1605
DI 10.1128/IAI.01452-08
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 419AM
UT WOS:000264191500036
PM 19188358
ER
PT J
AU Shanks, J
Burtnick, MN
Brett, PJ
Waag, DM
Spurgers, KB
Ribot, WJ
Schell, MA
Panchal, RG
Gherardini, FC
Wilkinson, KD
DeShazer, D
AF Shanks, John
Burtnick, Mary N.
Brett, Paul J.
Waag, David M.
Spurgers, Kevin B.
Ribot, Wilson J.
Schell, Mark A.
Panchal, Rekha G.
Gherardini, Frank C.
Wilkinson, Keith D.
DeShazer, David
TI Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is
Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages
SO INFECTION AND IMMUNITY
LA English
DT Article
ID UBIQUITIN-LIKE PROTEINS; NF-KAPPA-B; VIRULENCE DETERMINANT; VI
SECRETION; GLANDERS; PSEUDOMALLEI; SYSTEM; ENZYMES; BACTERIA; MUTANTS
AB Burkholderia mallei, a category B biothreat agent, is a facultative intracellular pathogen that causes the zoonotic disease glanders. The B. mallei VirAG two-component regulatory system activates the transcription of similar to 60 genes, including a large virulence gene cluster encoding a type VI secretion system (T6SS). The B. mallei tssM gene encodes a putative ubiquitin-specific protease that is physically linked to, and transcriptionally coregulated with, the T6SS gene cluster. Mass spectrometry and immunoblot analysis demonstrated that TssM was secreted in a virAG-dependent manner in vitro. Surprisingly, the T6SS was found to be dispensable for the secretion of TssM. The C-terminal half of TssM, which contains Cys and His box motifs conserved in eukaryotic deubiquitinases, was purified and biochemically characterized. Recombinant TssM hydrolyzed multiple ubiquitinated substrates and the cysteine at position 102 was critical for enzymatic activity. The tssM gene was expressed within 1 h after uptake of B. mallei into RAW 264.7 murine macrophages, suggesting that the TssM deubiquitinase is produced in this intracellular niche. Although the physiological substrate(s) is currently unknown, the TssM deubiquitinase may provide B. mallei a selective advantage in the intracellular environment during infection.
C1 [Waag, David M.; Spurgers, Kevin B.; Ribot, Wilson J.; Panchal, Rekha G.; DeShazer, David] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
[Shanks, John; Wilkinson, Keith D.] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA.
[Burtnick, Mary N.; Brett, Paul J.; Gherardini, Frank C.] NIAID, Lab Zoonot Pathogens, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
[Schell, Mark A.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA.
RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM david.deshazer@amedd.army.mil
FU Medical Biological Defense Research Program; U. S. Army Medical Research
and Materiel Command [06-4-2P-004]; NIAID Interagency Agreement
[Y1-AI-5004-01]; National Institutes of Health [GM030308, GM066355,
1-R21-I069081]
FX We are grateful to Vinod Nair for assistance with confocal microscopy
and to Anthony Bassett for assistance with animal experiments.; The
research described here was sponsored by the Medical Biological Defense
Research Program, U. S. Army Medical Research and Materiel Command,
Project 06-4-2P-004 (to D. D.), NIAID Interagency Agreement
Y1-AI-5004-01 (to D. D.), and National Institutes of Health grants
GM030308 and GM066355 (to K. D. W.) and 1-R21-I069081 (to M. A. S.).;
The opinions, interpretations, conclusions, and recommendations are
those of the authors and are not necessarily endorsed by the U. S. Army
in accordance with AR 70-31.
NR 65
TC 28
Z9 30
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD APR
PY 2009
VL 77
IS 4
BP 1636
EP 1648
DI 10.1128/IAI.01339-08
PG 13
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 419AM
UT WOS:000264191500040
PM 19168747
ER
PT J
AU Linehan, WM
Rubin, JS
Bottaro, DP
AF Linehan, W. Marston
Rubin, Jeffrey S.
Bottaro, Donald P.
TI VHL loss of function and its impact on oncogenic signaling networks in
clear cell renal cell carcinoma
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE VHL; HIF; Oncogenesis; HGF; beta-Catenin; Renal cell carcinoma
ID HEPATOCYTE GROWTH-FACTOR; TUMOR-SUPPRESSOR GENE; BETA-CATENIN;
EXPRESSION; THERAPEUTICS; DISEASE; CANCER; HYPOXIA
AB Loss of von Hippel-Lindau tumor suppressor gene function occurs in familial and most sporadic clear cell renal cell carcinoma, resulting in the aberrant expression of genes that control cell proliferation, metabolism, invasion and angiogenesis. The molecular mechanisms by which loss of function leads to tumorigenesis are not yet fully defined. The von Hippel-Lindau gene product is part of an ubiquitin ligase complex that targets hypoxia inducible factors for polyubiquitination and proteasomal degradation, linking hypoxia response genes to renal cell carcinoma oncogenesis. Loss von Hippel-Lindau gene function also promotes cell invasiveness in response to hepatocyte growth factor, an important regulator of kidney development and renal homeostasis. Increased cell invasiveness is mediated by another ubiquitin ligase target with relevance to the molecular pathogenesis of renal cell carcinoma: P-catenin. This discovery and other recent insights into kidney cancer oncogenesis implicate convergent developmental and homeostatic signaling pathways in tumorigenesis, tumor invasiveness and metastasis. Published by Elsevier Ltd.
C1 [Linehan, W. Marston; Bottaro, Donald P.] NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Rubin, Jeffrey S.] NCI, Cellular & Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Bottaro, DP (reprint author), NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bldg 10,CRC,Rm 2-3952,10 Ctr Dr,MSC 1107, Bethesda, MD 20892 USA.
EM dbottaro@helix.nih.gov
RI Bottaro, Donald/F-8550-2010
OI Bottaro, Donald/0000-0002-5057-5334
FU NIH; National Cancer Institute; Center for Cancer Research
FX This work was supported by the Intramural Research Program of the NIH,
National Cancer Institute, Center for Cancer Research. The authors
regret that not all relevant original reports could be cited due to
space limitations.
NR 22
TC 26
Z9 28
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD APR
PY 2009
VL 41
IS 4
BP 753
EP 756
DI 10.1016/j.biocel.2008.09.024
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 417BO
UT WOS:000264049800012
PM 18950731
ER
PT J
AU Goldin, LR
Landgren, O
AF Goldin, Lynn R.
Landgren, Ola
TI Autoimmunity and lymphomagenesis
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Review
DE autoimmunity; lymphoma; association; immune mechanism
ID CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKIN-LYMPHOMA; RESPIRATORY-TRACT
INFECTIONS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HEPATITIS-C VIRUS;
RHEUMATOID-ARTHRITIS; SJOGRENS-SYNDROME; LYMPHOPROLIFERATIVE DISORDERS;
UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY
AB For more than 50 years, links between autoimmunity and lymphomas have been described based on human and animal studies. Over the last 3 decades, many studies have addressed specific hypotheses about these associations using population level data. This has been accomplished by assessing previous autoimmune history in case-control studies of patients with lymphoma (mainly non-Hodgkin lymphoma) and myeloma, and by following cohorts of patients with various autoimmune diseases for subsequent development of lymphoma and multiple myeloma. In this article, we review our recently published series of association studies based on data from Scandinavia and from US Veterans and other relevant findings. We also discuss what these associations have revealed about the mechanisms and pathways underlying both autoimmunity and lymphoma. Finally, we discuss the future directions involving a combination of population and molecular studies that are needed to better define underlying biological mechanisms. Published 2008 Wiley-Liss, Inc.
C1 [Goldin, Lynn R.; Landgren, Ola] NCI, Genet Epidemiol Branch, DCEG, NIH, Bethesda, MD 20892 USA.
RP Goldin, LR (reprint author), NCI, Genet Epidemiol Branch, DCEG, NIH, 6120 Execut Blvd Rm 7008,MSC 7236, Bethesda, MD 20892 USA.
EM goldinl@mail.nih.gov
FU Intramural Research Program of the National Cancer Institute,; National
Institutes of Health
FX Grant sponsors: Intramural Research Program of the National Cancer
Institute, National Institutes of Health.
NR 56
TC 57
Z9 58
U1 0
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2009
VL 124
IS 7
BP 1497
EP 1502
DI 10.1002/ijc.24141
PG 6
WC Oncology
SC Oncology
GA 413PL
UT WOS:000263804900001
PM 19089924
ER
PT J
AU Habermann, JK
Doering, J
Hautaniemi, S
Roblick, UJ
Bundgen, NK
Nicorici, D
Kronenwett, U
Rathnagiriswaran, S
Mettu, RKR
Ma, Y
Kruger, S
Bruch, HP
Auer, G
Guo, NL
Ried, T
AF Habermann, Jens K.
Doering, Jana
Hautaniemi, Sampsa
Roblick, Uwe J.
Buendgen, Nana K.
Nicorici, Daniel
Kronenwett, Ulrike
Rathnagiriswaran, Shruti
Mettu, Rama K. R.
Ma, Yan
Krueger, Stefan
Bruch, Hans-Peter
Auer, Gert
Guo, Nancy L.
Ried, Thomas
TI The gene expression signature of genomic instability in breast cancer is
an independent predictor of clinical outcome
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE breast cancer; gene expression; genomic instability; aneuploidy;
prognosis
ID NUCLEAR-DNA CONTENT; PROGNOSTIC-SIGNIFICANCE; CENTROSOME ABERRATIONS;
CELL-LINES; PATTERNS; CARCINOMAS; CLASSIFICATION; SUBTYPES; SURVIVAL;
TUMORS
AB Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instability provides a very similar stratification of prognostic groups. We therefore hypothesized that these features are linked. We used gene expression profiling of 48 breast cancer specimens that profoundly differed in their degree of genomic instability and identified a set of 12 genes that defines the 2 groups. The biological and prognostic significance of this gene set was established through survival prediction in published datasets from patients with breast cancer. Of note, the gene expression signatures that define specific prognostic subtypes in other breast cancer datasets, such as luminal A and B, basal normal-like and ERBB2+, and prognostic signatures including MammaPrint (R) and Oncotype DX, predicted genomic instability in our samples. This remarkable congruence suggests a biological interdependence of poor-prognosis gene signatures, breast cancer subtypes, genomic instability, and clinical outcome. (C) 2008 Wiley-Liss. Inc.
C1 [Habermann, Jens K.; Ried, Thomas] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
[Habermann, Jens K.; Doering, Jana; Roblick, Uwe J.; Buendgen, Nana K.; Bruch, Hans-Peter] Univ Hosp Schleswig Holstein, Dept Surg, Lubeck, Germany.
[Habermann, Jens K.; Roblick, Uwe J.; Kronenwett, Ulrike; Auer, Gert] Karolinska Inst, Karolinska Biom Ctr KBC, Stockholm, Sweden.
[Hautaniemi, Sampsa] Univ Helsinki, Biomedicum Helsinki & Inst Biomed, Genome Scale Biol Res Program, Computat Syst Biol Lab, Helsinki, Finland.
[Nicorici, Daniel] Tampere Univ Technol, Inst Signal Proc, FIN-33101 Tampere, Finland.
[Rathnagiriswaran, Shruti; Mettu, Rama K. R.; Ma, Yan; Guo, Nancy L.] W Virginia Univ, MBR Canc Ctr, Dept Community Med, Morgantown, WV 26506 USA.
[Krueger, Stefan] Univ Hosp Schleswig Holstein, Inst Pathol, Lubeck, Germany.
RP Guo, NL (reprint author), NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
EM lguo@hsc.wvu.edu
RI Hautaniemi, Sampsa/A-3122-2009; Bruch, Hans-Peter/E-7731-2010;
Habermann, Jens/E-2968-2010
OI Hautaniemi, Sampsa/0000-0002-7749-2694;
FU Swedish Cancer Society (Cancerfonden); Cancer Society
(Cancerforeningen), Stockholm, Sweden; Biocentrum Helsinki, Finland; NIH
(Intramural Research Program), National Cancer Institute; Medical
University of Lubeck [NIH/NCRR P20 RR 16440-03]
FX Grant sponsors: Swedish Cancer Society (Cancerfonden), the Cancer
Society (Cancerforeningen), Stockholm, Sweden, the Biocentrum Helsinki,
Finland, NIH (Intramural Research Program), National Cancer Institute;
Grant sponsor: Medical University of Lubeck; Grant number: NIH/NCRR P20
RR 16440-03.
NR 48
TC 42
Z9 43
U1 1
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2009
VL 124
IS 7
BP 1552
EP 1564
DI 10.1002/ijc.24017
PG 13
WC Oncology
SC Oncology
GA 413PL
UT WOS:000263804900007
PM 19101988
ER
PT J
AU Yu, KJ
Hsu, WL
Chiang, CJ
Cheng, YJ
Pfeiffer, RM
Diehl, SR
Goldstein, AM
Gravitt, PE
Chen, CJ
Hildesheim, A
AF Yu, Kelly. J.
Hsu, Wan-Lun
Chiang, Chun-Ju
Cheng, Yu-Juen
Pfeiffer, Ruth M.
Diehl, Scott R.
Goldstein, Alisa M.
Gravitt, Patti E.
Chen, Chien-Jen
Hildesheim, Allan
TI Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE Epstein-Barr virus; nasopharyngeal carcinoma; epidemiology; genetics
ID EPSTEIN-BARR-VIRUS; RISK; SUSCEPTIBILITY; INDIVIDUALS; ASSOCIATION
AB Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1-1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10-23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83-1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5-2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors. (C) 2008 Wiley-Liss. Inc.
C1 [Yu, Kelly. J.] NCI, DCEG, Infect & Immunoepidemiol Branch, NIH,DHHS, Bethesda, MD 20852 USA.
[Hsu, Wan-Lun; Chiang, Chun-Ju; Cheng, Yu-Juen; Chen, Chien-Jen] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan.
[Hsu, Wan-Lun; Chiang, Chun-Ju; Chen, Chien-Jen] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan.
[Diehl, Scott R.] Univ Med & Dent New Jersey, New Jersey Dent Sch, Ctr Pharmacogenom & Complex Dis Res, Newark, NJ 07103 USA.
[Gravitt, Patti E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol & Mol Microbiol & Immunol, Baltimore, MD USA.
RP Yu, KJ (reprint author), NCI, DCEG, Infect & Immunoepidemiol Branch, NIH,DHHS, 6120 Execut Blvd,Room 7057, Bethesda, MD 20852 USA.
EM yuke@mail.nih.gov
RI Chen, Chien-Jen/C-6976-2008; Pfeiffer, Ruth /F-4748-2011; Hildesheim,
Allan/B-9760-2015
OI Hildesheim, Allan/0000-0003-0257-2363
FU Intramural NIH HHS [Z01 CP010158-07]
NR 15
TC 15
Z9 15
U1 0
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2009
VL 124
IS 7
BP 1622
EP 1625
DI 10.1002/ijc.24051
PG 4
WC Oncology
SC Oncology
GA 413PL
UT WOS:000263804900015
PM 19065653
ER
PT J
AU Gaudet, MM
Hunter, K
Pharoah, P
Dunning, AM
Driver, K
Lissowska, J
Sherman, M
Peplonska, B
Brinton, LA
Chanock, S
Garcia-Closas, M
AF Gaudet, Mia M.
Hunter, Kent
Pharoah, Paul
Dunning, Alison M.
Driver, Kristy
Lissowska, Jolanta
Sherman, Mark
Peplonska, Beata
Brinton, Louise A.
Chanock, Stephen
Garcia-Closas, Montserrat
TI Genetic variation in SIPA1 in relation to breast cancer risk and
survival after breast cancer diagnosis
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
ID GTPASE-ACTIVATING PROTEIN; METASTASIS; POLYMORPHISMS; PROGRESSION;
PROGNOSIS; MODELS; RAP1
AB Genetic variation in SIPA1, signal-induced proliferation-associated gene 1, has been proposed to be associated with aggressive breast tumor characteristics related to metastasis and worse prognosis in humans and rodents. To test this hypothesis, we genotyped 3 single nucleotide polymorphisms (SNP) located at -3092 (AT, rs3741378), and exon 14 + 14 (C>T, rs746429), and examined them in relation to breast cancer risk and overall survival, stratified by tumor characteristics in 2 independent case-control studies conducted in Poland (1,995 cases, 2,296 controls) and in Britain (2,142 cases, 2,257 controls). Vital status (it = 396 deaths) was available for 911 Polish and 1,919 British breast cancer cases with an average follow-up time of 5.5 years. Overall, we found no significant associations between genetic variants of SIPA1 SNPs and breast cancer risk (per allele odds ratios, 95% confidence intervals (Cl): rs931127-0.99, 0.93-1.06; rs3741378-1.03, 0.94-1.13; and, rs74642-0.98, 0.92-1.04). In both studies, SIPA1 polymorphisms were not related to overall mortality (per allele hazard ratios, 95% CI: 1.02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.94-4.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival. Published 2008 Wiley-Liss, Inc.
C1 [Gaudet, Mia M.; Lissowska, Jolanta; Sherman, Mark; Brinton, Louise A.; Chanock, Stephen; Garcia-Closas, Montserrat] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Hunter, Kent] NCI, Lab Populat Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Pharoah, Paul; Dunning, Alison M.; Driver, Kristy] Univ Cambridge, Canc Res UK Human Canc Genet Res Grp, Dept Oncol, Cambridge, England.
[Lissowska, Jolanta] M Sklodowska Curie Mem Canc Ctr, Dept Canc Epidemiol & Prevent, Warsaw, Poland.
[Lissowska, Jolanta] Inst Oncol, Warsaw, Poland.
[Peplonska, Beata] Nofer Inst Occupat Med, Dept Occupat & Environm Epidemiol, Lodz, Poland.
[Chanock, Stephen] NCI, Core Genotype Facil, Adv Technol Ctr, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
RP Gaudet, MM (reprint author), Mem Sloan Kettering Canc Ctr, 307 E 63rd St,3rd Floor, New York, NY 10021 USA.
EM gaudetm@mskcc.org
RI Peplonska, Beata/F-6004-2010; Garcia-Closas, Montserrat /F-3871-2015;
Brinton, Louise/G-7486-2015;
OI Garcia-Closas, Montserrat /0000-0003-1033-2650; Brinton,
Louise/0000-0003-3853-8562; Lissowska, Jolanta/0000-0003-2695-5799;
Dunning, Alison Margaret/0000-0001-6651-7166
FU Cancer Research UK; National Cancer Institute, National Institutes of
Health; Intramural Research Funds of the National Cancer Institute;
Department of Health and Human Services, USA
FX Grant sponsor: Intramural Research Funds of the National Cancer
Institute, Department of Health and Human Services, USA.
NR 17
TC 11
Z9 13
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2009
VL 124
IS 7
BP 1716
EP 1720
DI 10.1002/ijc.23919
PG 5
WC Oncology
SC Oncology
GA 413PL
UT WOS:000263804900028
PM 19089925
ER
PT J
AU McLean, D
't Mannetje, A
Dryson, E
Walls, C
McKenzie, F
Maule, M
Cheng, S
Cunningham, C
Kromhout, H
Boffetta, P
Blair, A
Pearce, N
AF McLean, David
't Mannetje, Andrea
Dryson, Evan
Walls, Chris
McKenzie, Fiona
Maule, Milena
Cheng, Soo
Cunningham, Chris
Kromhout, Hans
Boffetta, Paolo
Blair, Aaron
Pearce, Neil
TI Leukaemia and occupation: a New Zealand Cancer Registry-based
casecontrol Study
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Leukaemia; occupation; casecontrol study; agricultural workers; plastics
industry
ID NON-HODGKINS-LYMPHOMA; ELECTRICAL WORKERS; ADULT LEUKEMIA;
MYELOID-LEUKEMIA; EMPIRICAL-BAYES; RISK; MORTALITY; INDUSTRY; EXPOSURE;
SURVEILLANCE
AB Background To examine the association between occupation and leukaemia.
Methods We interviewed 225 cases (aged 2075 years) notified to the New Zealand Cancer Registry during 200304, and 471 controls randomly selected from the Electoral Roll collecting demographic details, information on potential confounders and a comprehensive employment history. Associations between occupation and leukaemia were analysed using logistic regression adjusted for gender, age, ethnicity and smoking.
Results Elevated odds ratios (ORs) were observed in agricultural sectors including horticulture/fruit growing (OR: 2.62, 95 confidence interval (CI): 1.51, 4.55), plant nurseries (OR: 7.51, 95 CI: 1.85, 30.38) and vegetable growing (OR: 3.14, 95 CI: 1.18, 8.40); and appeared greater in women (ORs: 4.71, 7.75 and 7.98, respectively). Elevated ORs were also observed in market farmers/crop growers (OR: 1.84, 95 CI: 1.12, 3.02), field crop/vegetable growers (OR: 3.98, 95 CI: 1.46, 10.85), market gardeners (OR: 5.50, 95 CI: 1.59, 19.02), and nursery growers/workers (OR: 4.23, 95 CI: 1.34, 13.35); also greater in women (ORs: 3.48, 7.62, 15.74 and 11.70, respectively). These elevated ORs were predominantly for chronic lymphocytic leukaemia (CLL). Several associations persisted after semi-Bayes adjustment. Elevated ORs were observed in rubber/plastics products machine operators (OR: 3.76, 95 CI: 1.08, 13.08), predominantly in plastic product manufacturing. CLL was also elevated in tailors and dressmakers (OR: 7.01, 95 CI: 1.78, 27.68), cleaners (OR: 2.04, 95 CI: 1.00, 4.14) and builders labourers (OR: 4.03, 95 CI: 1.30, 12.53).
Conclusions These findings suggest increased leukaemia risks associated with certain agricultural, manufacturing, construction and service occupations in New Zealand.
C1 [McLean, David; 't Mannetje, Andrea; Dryson, Evan; Walls, Chris; McKenzie, Fiona; Cheng, Soo; Pearce, Neil] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand.
[Maule, Milena] Univ Turin, Canc Epidemiol Unit, CeRMS, Turin, Italy.
[Maule, Milena] Univ Turin, CPO Piemonte, Turin, Italy.
[Dryson, Evan; Walls, Chris] Occupat Med Specialists, Auckland, New Zealand.
[Cunningham, Chris] Massey Univ, Res Ctr Maori Hlth & Dev, Wellington, New Zealand.
[Kromhout, Hans] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
[Boffetta, Paolo] Int Agcy Res Canc, F-69372 Lyon, France.
[Blair, Aaron] NCI, Occupat & Environm Epidemiol Branch, Bethesda, MD 20892 USA.
RP McLean, D (reprint author), Massey Univ, Ctr Publ Hlth Res, Wellington Campus,Private Box 756, Wellington, New Zealand.
EM d.j.mclean@massey.ac.nz
OI Pearce, Neil/0000-0002-9938-7852
FU Health Research Council of New Zealand; New Zealand Department of
Labour; Lotteries Health Research; Cancer Society of New Zealand
FX The Health Research Council of New Zealand; the New Zealand Department
of Labour; Lotteries Health Research; the Cancer Society of New Zealand.
The Centre for Public Health Research is supported by a Programme Grant
from the Health Research Council.
NR 46
TC 12
Z9 13
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD APR
PY 2009
VL 38
IS 2
BP 594
EP 606
DI 10.1093/ije/dyn220
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 428ZJ
UT WOS:000264890300038
PM 18953052
ER
PT J
AU Chuang, J
Melrose, C
Knox, S
Iozzo, R
Whitelock, J
AF Chuang, J.
Melrose, C.
Knox, S.
Iozzo, R.
Whitelock, J.
TI The role of heparan sulfate on chondrocyte perlecan - to proliferate or
not?
SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
LA English
DT Meeting Abstract
CT Annual General Meeting of the British-Society-for-Matrix-Biology
CY APR 07-08, 2008
CL York Univ, York, ENGLAND
SP British Soc Matrix Biol
HO York Univ
C1 [Chuang, J.; Whitelock, J.] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia.
[Melrose, C.] RNSH St Leonards, Raymond Purves Bone Labs, Inst Bone & Joint Res, Sydney, NSW 2065, Australia.
[Knox, S.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA.
[Iozzo, R.] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0959-9673
J9 INT J EXP PATHOL
JI Int. J. Exp. Pathol.
PD APR
PY 2009
VL 90
IS 2
BP A102
EP A103
PG 2
WC Pathology
SC Pathology
GA 421FR
UT WOS:000264345300021
ER
PT J
AU Young, R
Boote, C
Swamynathan, SK
Quantock, AJ
Piatigorsky, J
Meek, KM
AF Young, R.
Boote, C.
Swamynathan, S. K.
Quantock, A. J.
Piatigorsky, J.
Meek, K. M.
TI Changes in collagen fibril spacing and diameter, and proteoglycan
organisation associated with stromal oedema in Klf4CN mouse corneas
SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
LA English
DT Meeting Abstract
CT Annual General Meeting of the British-Society-for-Matrix-Biology
CY APR 07-08, 2008
CL York Univ, York, ENGLAND
SP British Soc Matrix Biol
HO York Univ
C1 [Young, R.; Boote, C.; Quantock, A. J.; Meek, K. M.] Cardiff Univ, Cardiff, S Glam, Wales.
[Swamynathan, S. K.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
[Piatigorsky, J.] NEI, NIH, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0959-9673
J9 INT J EXP PATHOL
JI Int. J. Exp. Pathol.
PD APR
PY 2009
VL 90
IS 2
BP A135
EP A136
PG 2
WC Pathology
SC Pathology
GA 421FR
UT WOS:000264345300087
ER
PT J
AU Small, W
Du Bois, A
Bhatnagar, S
Reed, N
Pignata, S
Potter, R
Randall, M
Mirza, M
Trimble, E
Gaffney, D
AF Small, William, Jr.
Du Bois, Andreas
Bhatnagar, Saurabha
Reed, Nick
Pignata, Sandro
Potter, Richard
Randall, Marcus
Mirza, Monsoor
Trimble, Edward
Gaffney, David
CA GCIG
TI Practice Patterns of Radiotherapy in Endometrial Cancer Among Member
Groups of the Gynecologic Cancer Intergroup
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Endometrial cancer; Radiotherapy; Brachytherapy
ID STAGE-I; AMERICAN BRACHYTHERAPY; RADIATION-THERAPY; ONCOLOGY-GROUP;
CARCINOMA; RECOMMENDATIONS; ADENOCARCINOMA; IRRADIATION; SURGERY; TRIAL
AB Purpose: To describe radiotherapeutic practice of the treatment of endometrial cancer in members of the Gynecologic Cancer Intergroup (GCIG).
Methods: A survey was developed and distributed to the members of the GCIG. The GCIG is a global association of cooperative groups involved in the research and treatment of gynecologic neoplasms.
Results: Thirty-four surveys were returned from 13 different cooperative groups. For the treatment of endometrial cancer after hysterectomy, mean (SD) pelvic dose was 47.37 (2.32) Gy. The upper border of the pelvic field was L4/5 in 14 respondents, L5/S1 in 13 respondents, and not specified in 6 surveys. When vaginal brachytherapy (VBT) was used in conjunction with external beam radiotherapy, most groups used high dose rate versus low dose rate on 24 versus 5 respondents, respectively. Twenty-eight of the 34 respondents performed computed tomographic simulation. Intensity-modulated radiotherapy was used routinely in 3 of the 34 respondents. For a para-aortic field, the upper border was, most commonly, at the T12-L1 interspace (17 of the 28 respondents), and the mean (SD) dose was 46.15 (2.18) Gy. For VBT alone after hysterectomy, 23 groups performed high-dose-rate brachytherapy (27.57 [10.13] Gy in a mean of 4.3 insertions), and 5 groups used low-dose-rate brachytherapy (41.45 [17.5] Gy). Nineteen of the 28 respondents measured the doses to the bladder and the rectum when performing VBT. For brachytherapy, there was no uniformity in the fraction of the vagina treated or the doses and schedules used.
Conclusions: Radiotherapy practices among member groups of the GCIG are similar in doses and dose per fraction with external beam. There is a moderate discrepancy in the brachytherapy practice after hysterectomy. There are no serious impediments to intergroup participation in radiation oncology practices among GCIG members with the use of external beam.
C1 [Small, William, Jr.; Bhatnagar, Saurabha; Gaffney, David] RTOG, Philadelphia, PA USA.
[Randall, Marcus] GOG, Philadelphia, PA USA.
[Du Bois, Andreas] AGO OVAR, Wiesbaden, Germany.
[Reed, Nick] EORTC, Glasgow, Lanark, Scotland.
[Pignata, Sandro] MITO, Naples, Italy.
[Potter, Richard] AGO AUST, Vienna, Austria.
[Mirza, Monsoor] NSGO, Odense, Denmark.
[Trimble, Edward] NCI, Bethesda, MD 20892 USA.
RP Small, W (reprint author), Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Galter LC-178,251 E Huron St, Chicago, IL 60611 USA.
EM wsmall@nmff.org
NR 13
TC 14
Z9 14
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1048-891X
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD APR
PY 2009
VL 19
IS 3
BP 395
EP 399
DI 10.1111/IGC.0b013e3181a1cee8
PG 5
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 457ZE
UT WOS:000266976600017
PM 19407566
ER
PT J
AU Sharov, AA
AF Sharov, Alexei A.
TI Coenzyme Autocatalytic Network on the Surface of Oil Microspheres as a
Model for the Origin of Life
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Origin of life; coenzyme world; RNA world; hydrocarbon; coding relation
ID METABOLISM; EVOLUTION; SYSTEM; 1ST; HYDROCARBONS; COEVOLUTION; MOLECULE;
WORLD; RNA
AB Coenzymes are often considered as remnants of primordial metabolism, but not as hereditary molecules. I suggest that coenzyme-like molecules (CLMs) performed hereditary functions before the emergence of nucleic acids. Autocatalytic CLMs modified (encoded) surface properties of hydrocarbon microspheres, to which they were anchored, and these changes enhanced autocatalysis and propagation of CLMs. Heredity started from a single kind of self-reproducing CLM, and then evolved into more complex coenzyme autocatalytic networks containing multiple kinds of CLMs. Polymerization of CLMs on the surface of microspheres and development of template-based synthesis is a potential evolutionary path towards the emergence of nucleic acids.
C1 NIA, Genet Lab, NIH, Baltimore, MD 21224 USA.
RP Sharov, AA (reprint author), NIA, Genet Lab, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM sharoval@mail.nih.gov
FU National Institute on Aging, NIH
FX This work was supported by the Intramural Research Program of the
National Institute on Aging, NIH.
NR 41
TC 7
Z9 8
U1 0
U2 4
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2009
VL 10
IS 4
BP 1838
EP 1852
DI 10.3390/ijms10041838
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
SC Biochemistry & Molecular Biology; Chemistry
GA 438BJ
UT WOS:000265530600027
PM 19468342
ER
PT J
AU Welch, LS
Anderson, HA
Balmes, J
Braun, L
Brody, A
Castleman, B
Davis, D
Dement, JM
Frank, A
Gochfeld, M
Goldstein, BD
Guzman, JR
Henderson, DW
Huff, J
Infante, PF
Ladou, J
Landrigan, PJ
Leigh, J
Levin, SM
Mulloy, KB
Michaels, D
Oliver, LC
Pepper, L
Rosenman, KD
Schwartz, BS
Silverstein, M
Sokas, RK
Takahashi, K
Takaro, TK
Teitelbaum, DT
Vojakovic, R
Watterson, A
AF Welch, Laura S.
Anderson, Henry A.
Balmes, John
Braun, Lundy
Brody, Arnold
Castleman, Barry
Davis, Devra
Dement, John M.
Frank, Arthur
Gochfeld, Michael
Goldstein, Bernard D.
Rodriguez Guzman, Julietta
Henderson, Douglas W.
Huff, James
Infante, Peter F.
LaDou, Joseph
Landrigan, Philip J.
Leigh, James
Levin, Stephen M.
Mulloy, Karen B.
Michaels, David
Oliver, L. Christine
Pepper, Lewis
Rosenman, Kenneth D.
Schwartz, Brian S.
Silverstein, Michael
Sokas, Rosemary K.
Takahashi, Ken
Takaro, Tim K.
Teitelbaum, Daniel Thau
Vojakovic, Robert
Watterson, Andrew
TI Research on Mesothelioma from Brake Exposure: Corporate Influence
Remains Relevant Concern
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Letter
ID MALIGNANT MESOTHELIOMA; ASBESTOS EXPOSURE; LUNG-CANCER; MECHANICS; RISK
C1 [Welch, Laura S.] CPWR, Silver Spring, MD USA.
[Welch, Laura S.] George Washington Univ, Sch Publ Hlth & Hlth Sci, Washington, DC 20052 USA.
[Anderson, Henry A.] Wisconsin Div Publ Hlth, Madison, WI USA.
[LaDou, Joseph] Univ Calif San Francisco, Sch Med, Int Ctr Occupat Med, San Francisco, CA 94143 USA.
[Balmes, John] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Braun, Lundy] Brown Univ, Dept Pathol, Providence, RI 02912 USA.
[Braun, Lundy] Brown Univ, Dept Lab Med, Providence, RI 02912 USA.
[Braun, Lundy] Brown Univ, Dept Africana Studies, Providence, RI 02912 USA.
[Brody, Arnold] N Carolina State Univ, Dept Mol & Biomed Sci, Raleigh, NC 27695 USA.
[Davis, Devra] Univ Pittsburgh, Inst Canc, Ctr Environm Oncol, Pittsburgh, PA 15260 USA.
[Davis, Devra] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
[Dement, John M.] Duke Univ, Med Ctr, Dept Community & Family Med, Div Occupat & Environm Med, Durham, NC 27710 USA.
[Frank, Arthur] Drexel Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA USA.
[Gochfeld, Michael] Rutgers State Univ, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
[Rodriguez Guzman, Julietta] Univ El Bosque, Bogota, Colombia.
[Henderson, Douglas W.] Flinders Univ S Australia, Adelaide, SA, Australia.
[Huff, James] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC USA.
[Michaels, David] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Environm & Occupat Hlth, Washington, DC USA.
[Levin, Stephen M.] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA.
[Leigh, James] Univ Sydney, Sch Publ Hlth, Ctr Environm & Occupat Hlth, Sydney, NSW 2006, Australia.
[Levin, Stephen M.] Mt Sinai Hosp, Mt Sinai IJ Selikoff Ctr Occupat & Environm Med, New York, NY 10029 USA.
[Mulloy, Karen B.] Denver Hlth Ctr Occupat Safety & Hlth, Denver, CO USA.
[Oliver, L. Christine] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
[Oliver, L. Christine] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Pepper, Lewis] Boston Univ, Sch Publ Hlth, Boston, MA USA.
[Rosenman, Kenneth D.] Michigan State Univ, Dept Med, Div Occupat & Environm Med, E Lansing, MI 48824 USA.
[Schwartz, Brian S.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Silverstein, Michael] Univ Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA.
[Sokas, Rosemary K.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA.
[Takahashi, Ken] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, WHO Collaborating Ctr Occupat Hlth, Kitakyushu, Fukuoka 807, Japan.
[Takaro, Tim K.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada.
[Teitelbaum, Daniel Thau] Colorado Sch Mines, Golden, CO 80401 USA.
[Teitelbaum, Daniel Thau] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
[Vojakovic, Robert] Asbestos Dis Soc Australia Inc, Osborn Pk, Australia.
[Watterson, Andrew] Univ Stirling, Occupat & Environm Hlth Res Grp, Stirling FK9 4LA, Scotland.
RP Welch, LS (reprint author), CPWR, Silver Spring, MD USA.
NR 13
TC 2
Z9 2
U1 1
U2 5
PU ABEL PUBLICATION SERVICES
PI BURLINGTON
PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA
SN 1077-3525
J9 INT J OCCUP ENV HEAL
JI Int. J. Occup. Environ. Health
PD APR-JUN
PY 2009
VL 15
IS 2
BP 234
EP 238
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 448IV
UT WOS:000266257200014
ER
PT J
AU Wang, PF
Li, SQ
Xiao, XS
Jia, XY
Jiao, XD
Guo, XM
Zhang, QJ
AF Wang, Panfeng
Li, Shiqiang
Xiao, Xueshan
Jia, Xiaoyun
Jiao, Xiaodong
Guo, Xiangming
Zhang, Qingjiong
TI High Myopia Is Not Associated with the SNPs in the TGIF, Lumican, TGFB1,
and HGF Genes
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; FACTOR-H
POLYMORPHISM; BETA-INDUCED FACTOR; GROWTH-FACTOR-BETA; HIGH-GRADE
MYOPIA; MACULAR DEGENERATION; CANDIDATE GENE; COMPLEX TRAITS;
SUSCEPTIBILITY LOCI
AB PURPOSE. Four single-nucleotide polymorphisms (SNPs) in the TGIF, lumican, TGFB1, and HGF genes have been declared to be associated with high myopia in Chinese living in southeast China, but none of them has been confirmed by additional studies. This study was conducted to verify the reported positive association results by analysis of subjects from the same region.
METHODS. DNA was prepared from venous leukocytes of 288 patients with high myopia and 208 control subjects. The four SNPs (rs2229336, rs3759223, rs1982073, and rs3735520) in the four genes were genotyped by restriction fragment length polymorphism (RFLP) analysis. The allele and genotype frequencies of these SNPs from patients and control subjects were compared by chi(2) test.
RESULTS. Polymorphism at rs2229336 was not detected in all 496 subjects. There were no statistically significant differences between patients and control subjects for the other three SNPs: rs3759223, rs1982073, and rs3735520.
CONCLUSIONS. The study does not support the association of high myopia with alleles of rs2229336 in TGIF, rs3759223 in lumican, rs1982073 in TGFB1, and rs3735520 in HGF. These results provide a view contrary to those in previous reports. Reasonable criteria as well as replication should be the first priority for genetic association studies to avoid excessive expansion of false-positive results, especially for high myopia. (Invest Ophthalmol Vis Sci. 2009; 50: 1546-1551) DOI:10.1167/iovs.08-2537
C1 [Wang, Panfeng; Li, Shiqiang; Xiao, Xueshan; Jia, Xiaoyun; Guo, Xiangming; Zhang, Qingjiong] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China.
[Jiao, Xiaodong] NEI, Ophthalm Genet & Visual Funct Branch, NIH, Bethesda, MD 20892 USA.
RP Zhang, QJ (reprint author), Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, 54 Xianlie Rd, Guangzhou 510060, Guangdong, Peoples R China.
EM qingjiongzhang@yahoo.com
FU National Science Fund [30725044]; National Natural Science Foundation of
China [30572006, 30772390]; Ministry of Education of China
[20050558073]; Bureau of Science and Technology of Guangzhou
[2006Z3-E0062]
FX Supported by Grant 30725044 from the National Science Fund for
Distinguished Young Scholars, Grants 30572006 and 30772390 from the
National Natural Science Foundation of China, Grant 20050558073 from the
Ministry of Education of China, and Grant 2006Z3-E0062 from the Bureau
of Science and Technology of Guangzhou.
NR 77
TC 29
Z9 34
U1 0
U2 2
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD APR
PY 2009
VL 50
IS 4
BP 1546
EP 1551
DI 10.1167/iovs.08-2537
PG 6
WC Ophthalmology
SC Ophthalmology
GA 424CP
UT WOS:000264543400010
PM 19060265
ER
PT J
AU Abbas, M
Bobo, LD
Hsieh, YH
Berka, N
Dunston, G
Bonney, GE
Apprey, V
Quinn, TC
West, SK
AF Abbas, Muneer
Bobo, Linda D.
Hsieh, Yu-Hsiang
Berka, Noureddine
Dunston, Georgia
Bonney, George E.
Apprey, Victor
Quinn, Thomas C.
West, Sheila K.
TI Human Leukocyte Antigen (HLA)-B, DRB1, and DQB1 Allotypes Associated
with Disease and Protection of Trachoma Endemic Villagers
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
ID OUTER-MEMBRANE PROTEIN; CD8(+) T-CELLS; HLA CLASS-I;
CHLAMYDIA-TRACHOMATIS; ACTIVE TRACHOMA; RISK-FACTORS; INFECTION; WOMEN;
CHILDREN; TANZANIA
AB PURPOSE. Trachoma remains the leading preventable infectious cause of blindness in developing countries. Human leukocyte antigen (HLA) associations with ocular disease severity and persistent Chlamydia trachomatis infection of Tanzanians living in trachoma-endemic villages were examined to determine possible protective candidate allotypes for vaccine development.
METHODS. Buccal swab scrapes were taken from subjects in the Trichiasis Study Group (TSG), which studied females only, and the Family Trachoma Study (FTS), which compared persistently infected probands who had severe disease with disease-free siblings and parents. DNA was purified for polymerase chain reaction sequence-specific oligonucleotide identification of HLA-DRB1, DQB1, and B allotypes. Infection was detected from conjunctival scrapes using a C. trachomatis-specific PCR-enzyme immunoassay for the MOMP-1 gene.
RESULTS. In the TSG, DR*B11 (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.26-0.90; P = 0.02) was significantly associated with lack of trichiasis, whereas HLA-B*07 (OR, 3.26; 95% CI, 1.42-7.49; P = 0.004) and HLA-B*08 (OR, 5.12; 95% CI, 1.74-15.05; P = 0.001) were associated with trichiasis. In addition, HLA-B*14 was significantly associated with inflammatory trachoma + follicular trachoma (OR, 3.76; 95% CI, 1.70-8.33; P = 0.04). There were no significant allele frequencies for the FTS.
CONCLUSIONS. The data suggest that HLA-DRB*11 may offer protection from trichiasis in trachoma hyperendemic villages. Complete allotype identification and designation of its respective protective CD4(+) T-cell antigens could provide a testable candidate vaccine for blindness prevention. Additionally, buccal swab DNA was sufficiently stable when acquired under harsh field conditions and stored long term in the freezer for low-resolution HLA typing. (Invest Ophthalmol Vis Sci. 2009; 50: 1734-1738) DOI:10.1167/iovs.08-2053
C1 [Abbas, Muneer; Dunston, Georgia; Bonney, George E.; Apprey, Victor] Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA.
[Bobo, Linda D.] Tufts Univ, Sch Med, Baystate Med Ctr, Dept Internal Med, Springfield, MA 01199 USA.
[Hsieh, Yu-Hsiang] Johns Hopkins Univ, Baltimore, MD USA.
[Berka, Noureddine] Tissue Typing Lab, Calgary Lab Serv, Calgary, AB, Canada.
[Bonney, George E.; Apprey, Victor] Howard Univ, Coll Med, Dept Community & Family Hlth, Baltimore, MD USA.
[Quinn, Thomas C.] Johns Hopkins Univ, Baltimore, MD USA.
[Quinn, Thomas C.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[West, Sheila K.] Johns Hopkins Univ, Dana Ctr Investigat Ophthalmol, Baltimore, MD USA.
RP Bobo, LD (reprint author), Washington Univ, Sch Med, Dept Adult Infect Dis, 1 Hosp Plaza,NW Tower 15th Floor, St Louis, MO 63130 USA.
EM lbobo@im.wustl.edu
FU National Institutes of Health; National Institute of Allergy and
Infectious Diseases [RR03048]; National Center for Research Resources
[2G12RR003048]; National Human Genome Center for the African Diaspora;
Howard University, Washington, DC
FX Supported by National Institutes of Health/National Institute of Allergy
and Infectious Diseases Grant RR03048; National Institutes of
Health/National Center for Research Resources Grant 2G12RR003048; and
the National Human Genome Center for the African Diaspora, Howard
University, Washington, DC.
NR 42
TC 7
Z9 7
U1 0
U2 1
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD APR
PY 2009
VL 50
IS 4
BP 1734
EP 1738
DI 10.1167/iovs.08-2053
PG 5
WC Ophthalmology
SC Ophthalmology
GA 424CP
UT WOS:000264543400035
PM 18824733
ER
PT J
AU Nottet, HSLM
van Dijk, SJ
Fanoy, EB
Goedegebuure, IW
de Jong, D
Vrisekoop, N
van Baarle, D
Boltz, V
Palmer, S
Borleffs, JCC
Boucher, CAB
AF Nottet, Hans S. L. M.
van Dijk, Sabine J.
Fanoy, Ewout B.
Goedegebuure, Irma W.
de Jong, Dorien
Vrisekoop, Nienke
van Baarle, Debbie
Boltz, Valerie
Palmer, Sarah
Borleffs, Jan C. C.
Boucher, Charles A. B.
TI HIV-1 Can Persist in Aged Memory CD4(+) T Lymphocytes With Minimal Signs
of Evolution After 8.3 Years of Effective Highly Active Antiretroviral
Therapy
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 15th International HIV Drug Resistance Workshop
CY JUN 13-17, 2006
CL Sitges, SPAIN
DE antiretroviral drug resistance; cellular reservoir; HIV-1 persistence;
long-term HAART; memory T cells; viral evolution
ID IMMUNODEFICIENCY-VIRUS TYPE-1; REPLICATION-COMPETENT HIV;
INHIBITOR-RESISTANT HIV-1; HIGH-LEVEL RESISTANCE; LATENT RESERVOIR;
COMBINATION THERAPY; DRUG-RESISTANCE; HIV-1-INFECTED PATIENTS; CELLULAR
RESERVOIRS; PRIMARY INFECTION
AB Background: Patients oil long-term highly active antiretroviral therapy (HAART) were studied to determine persistence, drug resistance development, and evolution of HIV-1 proviral DNA.
Methods: Peripheral blood mononuclear cells were obtained by large volume blood drawn (500 mL) from 8 clinically successfully treated patients who had received uninterrupted HAART for up to 8.9 years. HIV-1 load was determined by Taqman real-time polymerase chain reaction. Drug resistance mutations were determined by sequencing and ultrasensitive, allele-specific, reverse transcriptase (RT)-polymerase chain reaction.
Results: HIV-1 DNA load was significantly higher in aged memory (CD45RO(+) CD57(+)) when compared with memory (CD45RO(+) CD57(-)) and naive (CD27(+) CD45RO(-)) CD4(+) T cells after HAART. Sequencing revealed no major drug resistance Mutations in protease in all patients and appearance of resistance Mutations in RT in just 1 patient. In 1 of 5 patients with undetectable viremia during treatment, RT M184 substitutions were detected. Phylogenetic analysis showed short genetic distances between patient sequences.
Conclusions: During long-term HAART, HIV-1 is able to persist in terminally differentiated CD4(+) T cells as proviral DNA. Viral evolution was restricted, and in 80% of the patients with undetectable viremia, no sign of viral replication could be detected.
C1 [Nottet, Hans S. L. M.; van Dijk, Sabine J.; Fanoy, Ewout B.; Goedegebuure, Irma W.; de Jong, Dorien; Boucher, Charles A. B.] Univ Med Ctr Utrecht, Dept Med Microbiol, NL-3584 CX Utrecht, Netherlands.
[Vrisekoop, Nienke; van Baarle, Debbie] Univ Med Ctr Utrecht, Dept Immunol, Utrecht, Netherlands.
[Boltz, Valerie; Palmer, Sarah] NCI, HIV Drug Resistance Prog, Natl Inst Hlth, Frederick, MD 21701 USA.
[Borleffs, Jan C. C.] Univ Med Ctr Utrecht, Dept Internal Med, Utrecht, Netherlands.
RP Nottet, HSLM (reprint author), Univ Med Ctr Utrecht, Dept Med Microbiol, Hp G04614,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM h.s.l.m.nottet@umcutrecht.nl
NR 52
TC 21
Z9 21
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2009
VL 50
IS 4
BP 345
EP 353
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 422QL
UT WOS:000264442700001
PM 19214126
ER
PT J
AU Padayatty, SJ
Levine, M
AF Padayatty, Sebastian J.
Levine, Mark
TI Antioxidant Supplements and Cardiovascular Disease in Men
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
ID VITAMIN-C PHARMACOKINETICS
C1 [Padayatty, Sebastian J.; Levine, Mark] NIDDKD, Mol & Clin Nutr Sect, Digest Dis Branch, NIH, Bethesda, MD 20892 USA.
RP Padayatty, SJ (reprint author), NIDDKD, Mol & Clin Nutr Sect, Digest Dis Branch, NIH, Bethesda, MD 20892 USA.
EM markl@intra.niddk.nih.gov
RI Padayatty, Sebastian/A-8581-2012
OI Padayatty, Sebastian/0000-0001-8758-3170
NR 5
TC 3
Z9 3
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 1
PY 2009
VL 301
IS 13
BP 1336
EP 1336
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 426LM
UT WOS:000264709800015
PM 19336705
ER
PT J
AU Denny, C
Emanuel, EJ
AF Denny, Colleen
Emanuel, Ezekiel J.
TI Distributing US Health Aid In Reply
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
C1 [Denny, Colleen; Emanuel, Ezekiel J.] NIH, Dept Bioeth, Ctr Clin, Bethesda, MD 20892 USA.
RP Denny, C (reprint author), NIH, Dept Bioeth, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM eemanuel@nih.gov
NR 1
TC 0
Z9 0
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 1
PY 2009
VL 301
IS 13
BP 1340
EP 1340
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 426LM
UT WOS:000264709800022
ER
PT J
AU Roecklein, KA
Rohan, KJ
Duncan, WC
Rollag, MD
Rosenthal, NE
Lipsky, RH
Provencio, I
AF Roecklein, Kathryn A.
Rohan, Kelly J.
Duncan, Wallace C.
Rollag, Mark D.
Rosenthal, Norman E.
Lipsky, Robert H.
Provencio, Ignacio
TI A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal
affective disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Melanopsin; Seasonal affective disorder; OPN4
ID RHODOPSIN RETINITIS-PIGMENTOSA; REPEAT LENGTH POLYMORPHISM; TRANSPORTER
PROMOTER GENE; LIGHT THERAPY; WINTER DEPRESSION; GANGLION-CELLS;
RECEPTOR GENE; KNOCKOUT MICE; BLIND MICE; RESPONSES
AB Background: Melanopsin, a non-visual photopigment, may play a role in aberrant responses to low winter light levels ill Seasonal Affective Disorder (SAD). We hypothesize that functional sequence variation in the melanopsin gene could contribute to increasing the light needed for normal functioning during winter in SAD.
Methods: Associations between alleles, genotypes, and haplotypes of melanopsin in SAD participants (n=130) were performed relative to controls with no history of psychopathology (n=90).
Results: SAD participants had a higher frequency of the homozygous minor genotype T/T) for the missense variant rs2675703 (P10L) than controls, compared to the combined frequencies of C/C and C/T Individuals with the T/T genotype were 5.6 times more likely to he in the SAD group than the control group, and all 7 (5%) of individuals with the T/T genotype at P10L were in the SAD group.
Limitations: The study examined only one molecular component of the non-visual light input pathway, and recruitment methods for the comparison groups differed.
Conclusion: These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. Characterizing the genetic basis for deficits ill the non-visual light input pathway has the potential to define mechanisms underlying the pathological response to light in SAD, which may improve treatment. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Rollag, Mark D.; Provencio, Ignacio] Univ Virginia, Dept Biol, Charlottesville, VA 22903 USA.
[Roecklein, Kathryn A.] Uniformed Serv Univ Hlth Sci, Grad Program Med Psychol, Bethesda, MD 20814 USA.
[Rohan, Kelly J.] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA.
[Duncan, Wallace C.] NIMH, Mood & Anxiety Disorder Program, NIH, Bethesda, MD 20892 USA.
[Rosenthal, Norman E.] Capital Clin Res Associates, Rockville, MD USA.
[Lipsky, Robert H.] NIAAA, Mol Genet Sect, Neurogenet Lab, NIH, Bethesda, MD USA.
RP Provencio, I (reprint author), Univ Virginia, Dept Biol, 281 Gilmer Hall,485 McCormick Rd, Charlottesville, VA 22903 USA.
EM ip7m@virginia.edu
OI Lipsky, Robert/0000-0001-7753-1473
FU Intramural NIH HHS; NIAAA NIH HHS [Z01 AA000325]; NIMH NIH HHS [F31
MH072054-02, 5-F31-MH072054-02, F31 MH072054]; NINDS NIH HHS [R01
NS052112, R01 NS052112-08, R01 NS052112-09, R01-NS052112-05]
NR 53
TC 58
Z9 60
U1 2
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR
PY 2009
VL 114
IS 1-3
BP 279
EP 285
DI 10.1016/j.jad.2008.08.005
PG 7
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 419MO
UT WOS:000264223900031
PM 18804284
ER
PT J
AU Nowak-Wegrzyn, AH
Bencharitiwong, R
Schwarz, J
David, G
Eggleston, P
Gergen, PJ
Liu, AH
Pongracic, JA
Sarpong, S
Sampson, HA
AF Nowak-Wegrzyn, Anna H.
Bencharitiwong, Ramon
Schwarz, John
David, Gloria
Eggleston, Peyton
Gergen, Peter J.
Liu, Andrew H.
Pongracic, Jacqueline A.
Sarpong, Sampson
Sampson, Hugh A.
TI Mediator release assay for assessment of biological potency of German
cockroach allergen extracts
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE Cockroach; cockroach allergy; cockroach extract; rat basophil leukemia
cells; passive sensitization; mediator release; mediator release assay;
extract potency; ID(50)EAL; biologic potency; cockroach extract
standardization
ID INNER-CITY CHILDREN; PRICK TEST; IN-VITRO; FOOD ALLERGY; HUMAN-SERUM;
IGE; ASTHMA; STANDARDIZATION; DIAGNOSIS; POLLEN
AB Background: Cockroach is an important allergen in inner-city asthma. The diagnosis and treatment of cockroach allergy has been impeded by the lack of standardized cockroach extracts.
Objective: We investigated the utility of a mediator release assay based on rat basophil leukemia (RBL) cells for comparing the potency of German cockroach extracts.
Methods: RBL cells (line 2H3) transfected with human Fc epsilon RI were passively sensitized with sera from subjects with cockroach allergy and stimulated with serial dilutions of 3 commercial cockroach extracts (1:10 weight/volume). In addition, the in-house prepared extract was tested in separate experiments with pooled sera that produced optimal performance in the RBL assay. N-hexosaminidase release (NHR) was used as a marker of RBL cell degranulation and was examined in relation to the intradermal skin test (ID(50)EAL) and serum cockroach-specific and total IgE levels.
Results: The median cockroach-specific IgE concentration in 60 subjects was 0.72 kU(A)/L (interquartile range, 0.35-2.97 kU(A)/L); 19 sera (responders) produced a minimum 10% NHR to more than 1 extract. Responders had higher median cockroach-specific IgE (7.4 vs 1.0 kU(A)/L) and total IgE (429 vs 300 kU/L) levels than nonresponders. Ranking of extract potency was consistent between the mediator release assay and the ID50EAL. For the in-house prepared cockroach extract, the dose-response curves were shifted according to the concentration of the extract. NHR was reproducible between different experiments by using pooled sera.
Conclusion: The mediator release assay measures biologic potency and correlates with the ID50EAL. It should be further evaluated to determine whether it could be used to replace intradermal skin test titration for assessing the potency of cockroach extract. (J Allergy Clin Immunol 2009;123:949-55.)
C1 [Nowak-Wegrzyn, Anna H.] Mt Sinai Sch Med, Dept Pediat, Div Pediat Allergy & Immunol, New York, NY 10029 USA.
[Schwarz, John; David, Gloria] Rho Inc, Chapel Hill, NC USA.
[Eggleston, Peyton] Johns Hopkins Univ, Sch Med, Div Pediat Allergy & Immunol, Baltimore, MD USA.
[Gergen, Peter J.] NIAID, Div Allergy Immunol & Transplantat, NIH, Bethesda, MD 20892 USA.
[Liu, Andrew H.] Natl Jewish Med & Res Ctr, Div Pediat Allergy & Immunol, Denver, CO USA.
[Liu, Andrew H.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
[Pongracic, Jacqueline A.] Childrens Mem Hosp, Div Pediat Allergy & Immunol, Chicago, IL 60614 USA.
[Sarpong, Sampson] Howard Univ, Dept Pediat & Child Hlth, Washington, DC 20059 USA.
RP Nowak-Wegrzyn, AH (reprint author), Mt Sinai Sch Med, Dept Pediat, Div Pediat Allergy & Immunol, Box 1198,1 Gustave L Levy Pl, New York, NY 10029 USA.
EM anna.nowak-wegrzyn@mssm.edu
FU National Institute of Allergy and Infectious Diseases, National
Institutes of Health [N01-AI-25496, NO1-AI-25482, AI 059318]
FX Supported in whole or in part by federal funds from the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health, under contract nos. N01-AI-25496 and NO1-AI-25482. A.
Nowak-Wegrzyn is supported in part by NIH NIAID AI 059318.
NR 43
TC 13
Z9 13
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD APR
PY 2009
VL 123
IS 4
BP 949
EP 955
DI 10.1016/j.jaci.2009.01.070
PG 7
WC Allergy; Immunology
SC Allergy; Immunology
GA 431JW
UT WOS:000265058600025
PM 19348929
ER
PT J
AU Rothney, M
Chen, K
AF Rothney, Megan
Chen, Kong
TI Intergeneration accelerometer differences and correction for on-board
frequency-based filtering Reply
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Letter
C1 [Rothney, Megan] NIDDK, NIH, Bethesda, MD 20892 USA.
RP Rothney, M (reprint author), NIDDK, NIH, 10 CRC Rm 6-3940,10 Ctr Dr, Bethesda, MD 20892 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD APR
PY 2009
VL 106
IS 4
BP 1474
EP 1475
DI 10.1152/japplphysiol.00048.2009
PG 2
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 427AW
UT WOS:000264753000068
ER
PT J
AU Beaule, C
Mitchell, JW
Lindberg, PT
Damadzic, R
Eiden, LE
Gillette, MU
AF Beaule, Christian
Mitchell, Jennifer W.
Lindberg, Peder T.
Damadzic, Ruslan
Eiden, Lee E.
Gillette, Martha U.
TI Temporally Restricted Role of Retinal PACAP: Integration of the
Phase-Advancing Light Signal to the SCN
SO JOURNAL OF BIOLOGICAL RHYTHMS
LA English
DT Article
DE circadian rhythms; glutamate; light signal; phase resetting;
phase-response curve (PRC); plasticity; pituitary adenylate
cyclase-activating peptide (PACAP); suprachiasmatic nucleus (SCN)
ID CYCLASE-ACTIVATING POLYPEPTIDE; LONG-TERM POTENTIATION; MICE LACKING
PACAP; SUPRACHIASMATIC NUCLEUS; CIRCADIAN-RHYTHM; RETINOHYPOTHALAMIC
TRACT; BIOLOGICAL CLOCK; GENE-EXPRESSION; TYPE-1 RECEPTOR; MUTANT MICE
AB Circadian rhythms in physiology and behavior are temporally synchronized to the day/night cycle through the action of light on the circadian clock. In mammals, transduction of the photic signal reaching the circadian oscillator in the suprachiasmatic nucleus (SCN) occurs through the release of glutamate and pituitary adenylate cyclase-activating peptide (PACAP). The authors' study aimed at clarifying the role played by PACAP in photic resetting and entrainment. They investigated the circadian response to light of PACAP-null mice lacking the 5th exon of the PACAP coding sequence. Specifically, they examined free-running rhythms, entrainment to 12-h light:12-h dark (LD) cycles, the phase-response curve (PRC) to single light pulses, entrainment to a 23-h T-cycle, re-entrainment to 6-h phase shifts in LD cycles, and light-induced c-Fos expression. PACAP-null and wild-type mice show similar free-running periods and similar entrainment to 12:12 LD cycles. However, the PRC of PACAP-null mice lacks a phase-advance portion. Surprisingly, despite the absence of phase advance to single light pulses, PACAP-null mice are able to entrain to a 23-h T-cycle, but with a significantly longer phase angle of entrainment than wild types. In addition, PACAP-null mice re-entrain more slowly to a 6-h phase advance of the LD cycle. Nevertheless, induction of c-Fos by light in late night is normal. In all experiments, PACAP-null mice show specific behavioral impairments in response to phase-advancing photic stimuli. These results suggest that PACAP is required for the normal integration of the phase-advancing light signal by the SCN.
C1 [Beaule, Christian; Mitchell, Jennifer W.; Gillette, Martha U.] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA.
[Beaule, Christian; Lindberg, Peder T.; Gillette, Martha U.] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA.
[Lindberg, Peder T.; Gillette, Martha U.] Univ Illinois, Med Scholars Program, Urbana, IL 61801 USA.
[Damadzic, Ruslan; Eiden, Lee E.] NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA.
RP Gillette, MU (reprint author), Univ Illinois, Dept Cell & Dev Biol, B107 CLSL,610 S Goodwin Ave, Urbana, IL 61801 USA.
EM mgillett@illinois.edu
RI Jelinek, Milan/C-8515-2011;
OI Eiden, Lee/0000-0001-7524-944X
FU Fonds de Recherche sur la Nature et les Technologies (Government of
Quebec); Canadian Institutes of Health Research (CIHR); National
Institutes of Health [GM07143, NS11158]; NIMH-IRP [Z01 MH002386-21,
HL08670, NS22155]
FX The authors recognize with gratitude generous support from Fonds de
Recherche sur la Nature et les Technologies (Government of Quebec) and
Canadian Institutes of Health Research (CIHR) (CB), as well as from the
National Institutes of Health (USA): GM07143 (PTL), NS11158 (JWM), in
part by NIMH-IRP Project 1 Z01 MH002386-21 (LEE), and HL08670 and
NS22155 (MUG).
NR 32
TC 11
Z9 11
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0748-7304
J9 J BIOL RHYTHM
JI J. Biol. Rhythms
PD APR
PY 2009
VL 24
IS 2
BP 126
EP 134
DI 10.1177/0748730409332037
PG 9
WC Biology; Physiology
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 428UX
UT WOS:000264877900004
PM 19382381
ER
PT J
AU Aggarwal, M
Brosh, RM
AF Aggarwal, Monika
Brosh, Robert M., Jr.
TI Hitting the Bull's Eye: Novel Directed Cancer Therapy Through
Helicase-Targeted Synthetic Lethality
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE SYNTHETIC LETHALITY; HELICASE; CANCER THERAPY; DNA REPAIR; ANTI-CANCER
DRUG
ID WERNER-SYNDROME PROTEIN; DOUBLE-STRAND BREAKS; BOX DNA HELICASE;
HOMOLOGOUS RECOMBINATION; ANTICANCER THERAPY; POLY(ADP-RIBOSE)
POLYMERASE; FLAP ENDONUCLEASE-1; MUS81 ENDONUCLEASE; NEUROSPORA-CRASSA;
REPLICATION FORK
AB Designing strategies for anti-cancer therapy have posed a significant challenge. One approach has been to inhibit specific DNA repair proteins and their respective pathways to enhance chemotherapy and radiation therapy used to treat cancer patients. Synthetic lethality represents an approach that exploits pre-existing DNA repair deficiencies in certain tumors to develop inhibitors of DNA repair pathways that compensate for the tumor-associated repair deficiency. Since helicases play critical roles in the DNA damage response and DNA repair, particularly in actively dividing and replicating cells, it is proposed that the identification and characterization of synthetic lethal relationships of DNA helicases will be of value in developing improved anti-cancer treatment strategies. In this review, we discuss this hypothesis and current evidence for synthetic lethal interactions of eukaryotic DNA helicases in model systems. J. Cell. Biochem. 106: 758-763, 2009. Published 2009 Wiley-Liss, Inc.
C1 [Aggarwal, Monika; Brosh, Robert M., Jr.] NIA, Lab Mol Gerontol, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.
RP Brosh, RM (reprint author), NIA, Lab Mol Gerontol, Biomed Res Ctr, NIH, 251 Bayview Dr,Suite 100,Rm 06B125, Baltimore, MD 21224 USA.
EM broshr@mail.nih.gov
FU NIH; National Institute on Aging
FX Intramural Research Program of the NIH; Grant sponsor: National
Institute on Aging.
NR 51
TC 19
Z9 19
U1 0
U2 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR 1
PY 2009
VL 106
IS 5
BP 758
EP 763
DI 10.1002/jcb.22048
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 425VE
UT WOS:000264664800003
PM 19173305
ER
PT J
AU Yang, JH
Xu, S
Shen, J
AF Yang, Jehoon
Xu, Su
Shen, Jun
TI Fast isotopic exchange between mitochondria and cytosol in brain
revealed by relayed C-13 magnetization transfer spectroscopy
SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
LA English
DT Article
DE in vivo C-13 magnetic resonance spectroscopy; magnetization transfer;
metabolic modeling; tricarboxylic acid cycle rate
ID KETOGLUTARATE GLUTAMATE EXCHANGE; TRICARBOXYLIC-ACID CYCLE; IN-VIVO;
RAT-BRAIN; RESONANCE-SPECTROSCOPY; ALPHA-KETOGLUTARATE;
GLUCOSE-UTILIZATION; TCA CYCLE; NMR; METABOLISM
AB In vivo C-13 magnetic resonance spectroscopy has been applied to studying brain metabolic processes by measuring C-13 label incorporation into cytosolic pools such as glutamate and aspartate. However, the rate of exchange between mitochondrial alpha-ketoglutarate/oxaloacetate and cytosolic glutamate/aspartate (V-x) extracted from metabolic modeling has been controversial. Because brain fumarase is exclusively located in the mitochondria, and mitochondrial fumarate is connected to cytosolic aspartate through a chain of fast exchange reactions, it is possible to directly measure V-x from the four-carbon side of the tricarboxylic acid cycle by magnetization transfer. In isoflurane-anesthetized adult rat brain, a relayed C-13 magnetization transfer effect on cytosolic aspartate C2 at 53.2 ppm was detected after extensive signal averaging with fumarate C2 at 136.1 ppm irradiated using selective radiofrequency pulses. Quantitative analysis using Bloch-McConnell equations and a four-site exchange model found that V-x approximate to 13-19 mu mol per g per min (>> V-TCA, the tricarboxylic acid cycle rate) when the longitudinal relaxation time of malate C2 was assumed to be within +/- 33% of that of aspartate C2. If V-x approximate to V-TCA, the isotopic exchange between mitochondria and cytosol would be too slow on the time scale of C-13 longitudinal relaxation to cause a detectable magnetization transfer effect.
C1 [Yang, Jehoon; Xu, Su; Shen, Jun] NIMH, Mol Imaging Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
[Yang, Jehoon] Samsung Biomed Res Inst, Seoul, South Korea.
RP Shen, J (reprint author), NIMH, Mol Imaging Branch, Intramural Res Program, NIH, Bldg 10,Rm 2D51A,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM shenj@intra.nimh.nih.gov
FU NIH, NIMH
FX The authors thank Mr Christopher S Johnson for technical assistance, and
Ms Ioline Henter for help with preparation of the manuscript. This work
is supported by the Intramural Research Program of the NIH, NIMH.
NR 40
TC 9
Z9 9
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0271-678X
J9 J CEREBR BLOOD F MET
JI J. Cereb. Blood Flow Metab.
PD APR
PY 2009
VL 29
IS 4
BP 661
EP 669
DI 10.1038/jcbfm.2008.170
PG 9
WC Endocrinology & Metabolism; Hematology; Neurosciences
SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology
GA 426XM
UT WOS:000264741700001
PM 19156161
ER
PT J
AU Shinomiya, K
Kobayashi, H
Motoyoshi, N
Inokuchi, N
Nakagomi, K
Ito, Y
AF Shinomiya, Kazufusa
Kobayashi, Hiroko
Motoyoshi, Naomi
Inokuchi, Norio
Nakagomi, Kazuya
Ito, Yoichiro
TI Countercurrent chromatographic separation and purification of various
ribonucleases using a small-scale cross-axis coil planet centrifuge with
aqueous-aqueous polymer phase systems
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
AND LIFE SCIENCES
LA English
DT Article
DE Countercurrent chromatography; Cross-axis coil planet centrifuge;
Protein; Ribonuclease; Aqueous-aqueous polymer phase system
ID AMINO-ACID-SEQUENCE; PARTITION EFFICIENCY; ROTARY SEALS; PROTEIN;
APPARATUS
AB Countercurrent chromatographic (CCC) separation and purification of various ribonucleases (RNases) was performed using the small-scale cross-axis coil planet centrifuge (X-axis CPC) with aqueous-aqueous polymer phase systems. RNases B and A were well resolved from each other with an aqueous-aqueous polymer phase system composed of 12.5%(w/w) polyethylene glycol (PEG) 1000 and 12.5%(w/w)dibasic potassium phosphate (pH 9.2) as the mobile lower phase. The commercial RNase A samples obtained from three different companies were also highly purified using the 16.0% (w/w) PEG 1000-6.3% (w/w) dibasic potassium phosphate-6.3% (w/w) monobasic potassium phosphate system (pH 6.6) using the upper phase as the mobile phase. Recombinant RNase Po-1, an RNase T-1 family enzyme, was further successfully separated from the crude extract using the same solvent system with the lower phase used as the mobile phase. The RNase activities were well preserved during the CCC separation. The overall results demonstrate that the small-scale X-axis CPC is useful for a simple and rapid purification of various RNases in a preparative-scale. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Shinomiya, Kazufusa; Kobayashi, Hiroko; Motoyoshi, Naomi; Inokuchi, Norio] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan.
[Nakagomi, Kazuya] Teikyo Univ, Fac Pharmaceut Sci, Sagamihara, Kanagawa 1990195, Japan.
[Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
RP Shinomiya, K (reprint author), Nihon Univ, Coll Pharm, 7-7-1 Narashinodai, Funabashi, Chiba 2748555, Japan.
EM shinomiya.kazufusa@nihon-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX This work was supported by a grant from the Ministry of Education,
Culture, Sports, Science and Technology of Japan.
NR 16
TC 7
Z9 7
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD APR 1
PY 2009
VL 877
IS 10
BP 955
EP 960
DI 10.1016/j.jchromb.2009.02.038
PG 6
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 432JU
UT WOS:000265130100016
PM 19272844
ER
PT J
AU Guettier, JM
Kam, A
Chang, R
Skarulis, MC
Cochran, C
Alexander, HR
Libutti, SK
Pingpank, JF
Gorden, P
AF Guettier, Jean-Marc
Kam, Anthony
Chang, Richard
Skarulis, Monica C.
Cochran, Craig
Alexander, H. Richard
Libutti, Steven K.
Pingpank, James F.
Gorden, Phillip
TI Localization of Insulinomas to Regions of the Pancreas by Intraarterial
Calcium Stimulation: The NIH Experience
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID ENDOSCOPIC ULTRASONOGRAPHY; CONGENITAL HYPERINSULINISM; PREOPERATIVE
LOCALIZATION; INTRAOPERATIVE ULTRASONOGRAPHY; NEUROENDOCRINE TUMORS;
DISTAL PANCREATECTOMY; OCCULT INSULINOMAS; ENDOCRINE TUMORS;
HYPOGLYCEMIA; RESECTION
AB Context: Selective intraarterial calcium injection of the major pancreatic arteries with hepatic venous sampling [calcium arterial stimulation (CaStim)] has been used as a localizing tool for insulinomas at the National Institutes of Health (NIH) since 1989. The accuracy of this technique for localizing insulinomas was reported for all cases until 1996.
Objectives: The aim of the study was to assess the accuracy and track record of the CaStim over time and in the context of evolving technology and to review issues related to result interpretation and procedure complications. CaStim was the only invasive preoperative localization modality used at our center. Endoscopic ultrasound (US) was not studied.
Design and Setting: We conducted a retrospective case review at a referral center.
Patients: Twenty-nine women and 16 men (mean age, 47 yr; range, 13-78) were diagnosed with an insulinoma from 1996-2008.
Intervention: A supervised fast was conducted to confirm the diagnosis of insulinoma. US, computed tomography (CT), magnetic resonance imaging (MRI), and CaStim were used as preoperative localization studies. Localization predicted by each preoperative test was compared to surgical localization for accuracy.
Main Outcome: We measured the accuracy of US, CT, MRI, and CaStim for localization of insulinomas preoperatively.
Results: All 45 patients had surgically proven insulinomas. Thirty-eight of 45 (84%) localized to the correct anatomical region by CaStim. In five of 45 (11%) patients, the CaStim was falsely negative. Two of 45 (4%) had false-positive localizations.
Conclusion: The CaStim has remained vastly superior to abdominal US, CT, or MRI over time as a preoperative localizing tool for insulinomas. The utility of the CaStim for this purpose and in this setting is thus validated. (J Clin Endocrinol Metab 94: 1074-1080, 2009)
C1 [Guettier, Jean-Marc; Skarulis, Monica C.; Cochran, Craig; Gorden, Phillip] NIDDK, NIH, Bethesda, MD 20892 USA.
[Kam, Anthony; Chang, Richard] NIH, Dept Radiol, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA.
[Alexander, H. Richard; Libutti, Steven K.; Pingpank, James F.] NCI, Surg Metab Sect, Surg Branch, NIH, Bethesda, MD 20892 USA.
[Kam, Anthony] Johns Hopkins Bayview Med Ctr, Dept Radiol, Baltimore, MD 21224 USA.
[Alexander, H. Richard] Univ Maryland, Med Ctr, Dept Surg, Baltimore, MD 21201 USA.
RP Guettier, JM (reprint author), NIDDK, NIH, Bldg 10,CRC 6-5940, Bethesda, MD 20892 USA.
EM guettierj@mail.nih.gov
NR 45
TC 58
Z9 65
U1 0
U2 2
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2009
VL 94
IS 4
BP 1074
EP 1080
DI 10.1210/jc.2008-1986
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 432PB
UT WOS:000265145100004
PM 19190102
ER
PT J
AU Feldstein, A
Kleiner, D
Kravetz, D
Buck, M
AF Feldstein, Ariel
Kleiner, David
Kravetz, David
Buck, Martina
TI Severe Hepatocellular Injury With Apoptosis Induced by a Hepatitis C
Polymerase Inhibitor
SO JOURNAL OF CLINICAL GASTROENTEROLOGY
LA English
DT Article
DE caspase; macrophage; mitochondria; hepatic stellate cell; cytochrome C
ID C/EBP-BETA PHOSPHORYLATION; LIVER-DISEASE; HEPATOTOXICITY; EXPRESSION;
DEATH
AB Goals: To describe the mechanisms of severe hepatocellular injury with apoptosis in 2 patients receiving hepatitis C virus (HCV)-796.
Background: HCV-796 is a hepatitis C polymerase inhibitor approved by the US Food and Drug Administration for a phase 2 study of the treatment of hepatitis C in combination with PEG-Interferon and ribavirin.
Results: The injury Occurred after more than 12 weeks of treatment, with a > 20-fold increase in serum alanine aminotransferase and aspartate aminotransferase, and a marked increase in total (and direct) bilirubin in the absence of cholestasis. There was no evidence of autoimmune or viral hepatitis. Involvement of the mitochondrial apoptotic pathway was demonstrated by (1) release of cytochrome C into the cytosol; (2) association of cytochrome C with apoptotic protease activating factor-1 in the cytosol (3) activation of initiator caspase 9; (4) activation of effector caspase 3; (5) increased serum caspase-3 cleaved cytokeratin-18 peptide; (6) nuclear fragmentation;, (7) mitochondrial structural abnormalities; (8) expression of light chain 3 B. an indicator of autophagy; (9) probable autophagy of mitochondria by autophagosomes; and (10) probable phagocytosis of apoptotic hepatocytes by activated macrophages. Immunoglobulin G immune complexes were identified in the hepatocytes and localized to the endoplasmic reticulum and Golgi of these patients after the drug-induced liver disease, reflecting a primary or secondary target. Hepatitis C treatment was discontinued at weeks 15 and 19 in patients I and 2, respectively. After more than 6 months off the medication, both patients normalized the serum alanine aminotransferase, aspartate aminotransferase. and total bilirubin with undetectable HCV RNA.
Conclusions: HCV-796 may cause severe hepatocellular injury and apoptosis, with a marked immune reaction in susceptible patients.
C1 [Kravetz, David; Buck, Martina] Vet Affairs Healthcare Med Ctr, Dept Med, La Jolla, CA 92161 USA.
[Kravetz, David; Buck, Martina] Univ Calif San Diego, San Diego, CA 92103 USA.
[Buck, Martina] Moores Canc Ctr, San Diego, CA USA.
[Kleiner, David] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
[Feldstein, Ariel] Cleveland Clin, Dept Pediat, Cleveland, OH 44106 USA.
RP Buck, M (reprint author), Vet Affairs Healthcare Med Ctr, Dept Med, 3350 Jolla Village Dr 111-D, La Jolla, CA 92161 USA.
EM mbuck@ucsd.edu
OI Kleiner, David/0000-0003-3442-4453
FU US National Institutes of Health [DK-38652, CA-90932]; Medical Research
Foundation; University of California, San Diego; National Cancer
Institute Howard Temin Award
FX Funded by US National Institutes of Health, grant nos. DK-38652 and
CA-90932; Medical Research Foundation, University of California, San
Diego Grant; and National Cancer Institute Howard Temin Award to Martina
Buck.
NR 26
TC 12
Z9 13
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0192-0790
J9 J CLIN GASTROENTEROL
JI J. Clin. Gastroenterol.
PD APR
PY 2009
VL 43
IS 4
BP 374
EP 381
PG 8
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 439MM
UT WOS:000265631200015
PM 19098685
ER
PT J
AU Insel, TR
AF Insel, Thomas R.
TI Disruptive insights in psychiatry: transforming a clinical discipline
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID GENOME-WIDE ASSOCIATION; COMORBIDITY SURVEY REPLICATION; RANDOMIZED
CONTROLLED-TRIAL; INFLAMMATORY-BOWEL-DISEASE; MACULAR DEGENERATION;
ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; MAJOR DEPRESSION;
MENTAL-DISORDERS; RISK LOCI
AB Mental disorders such as schizophrenia, bipolar illness, and depression have become the predominant chronic diseases of young people, accounting for approximately 40% of the medical burden for people aged 15-44 in the United States and Canada. Research is transforming our understanding of these disorders, as exemplified in the articles in this Review Series. Important, "disruptive" insights into pathophysiology are emerging from studies addressing these illnesses as brain disorders, developmental disorders, and complex genetic disorders - rather than only as psychological conflicts or chemical imbalances, as they were considered in the past. Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover.
C1 NIMH, NIH, Bethesda, MD 20892 USA.
RP Insel, TR (reprint author), NIMH, NIH, 6001 Executive Blvd,Room 8235,MSC 9669, Bethesda, MD 20892 USA.
EM tinsel@mail.nih.gov
NR 64
TC 58
Z9 60
U1 5
U2 13
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD APR
PY 2009
VL 119
IS 4
BP 700
EP 705
DI 10.1172/JCI38832
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 428EF
UT WOS:000264830100005
PM 19339761
ER
PT J
AU Martinowich, K
Schloesser, RJ
Manji, HK
AF Martinowich, Keri
Schloesser, Robert J.
Manji, Husseini K.
TI Bipolar disorder: from genes to behavior pathways
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID GLYCOGEN-SYNTHASE KINASE-3; DORSOLATERAL PREFRONTAL CORTEX; WHITE-MATTER
HYPERINTENSITIES; MAJOR DEPRESSIVE DISORDER; GENOME-WIDE ASSOCIATION;
MAGNETIC-RESONANCE-SPECTROSCOPY; ADULT HIPPOCAMPAL NEUROGENESIS;
ANTERIOR CINGULATE CORTEX; PROTON MR SPECTROSCOPY; N-ACETYL-ASPARTATE
AB Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent episodes of mania and depression. In addition to these cyclic episodes, individuals with BPD exhibit changes in psychovegetative function, cognitive performance, and general health and well being. In this article we draw from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as data from animal models of behavior to discuss the neurobiology of BPD. We conclude with a synthesis of where the field stands and with suggestions and strategies for future areas of study to further increase our conceptual understanding of this complex illness.
C1 [Martinowich, Keri; Schloesser, Robert J.; Manji, Husseini K.] NIMH, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
RP Manji, HK (reprint author), Johnson & Johnson Pharmaceut Res & Dev, 1125 Trenton Harbourton Rd,E32000, Titusville, NJ 08560 USA.
EM hmanji@its.jnj.com
RI Martinowich, Keri/F-9841-2012;
OI Martinowich, Keri/0000-0002-5237-0789
NR 138
TC 58
Z9 58
U1 1
U2 14
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD APR
PY 2009
VL 119
IS 4
BP 726
EP 736
DI 10.1172/JCI37703
PG 11
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 428EF
UT WOS:000264830100008
PM 19339764
ER
PT J
AU Kalra, SK
Swedo, SE
AF Kalra, Simran K.
Swedo, Susan E.
TI Children with obsessive-compulsive disorder: are they just "little
adults"?
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID COGNITIVE-BEHAVIORAL THERAPY; GLUCOSE METABOLIC-RATE; OPEN-LABEL TRIAL;
TOURETTE-SYNDROME; NEUROPSYCHIATRIC DISORDERS; DOUBLE-BLIND;
ANTIPSYCHOTIC AUGMENTATION; SEROTONERGIC RESPONSIVITY; RISPERIDONE
AUGMENTATION; STREPTOCOCCAL INFECTIONS
AB Childhood-onset obsessive-compulsive disorder (OCD) affects 1%-2% of children and adolescents. It is characterized by recurrent obsessions and compulsions that create distress and interfere with daily life. The symptoms reported by children are similar to those seen among individuals who develop OCD in adulthood, and the two groups of patients are treated with similar symptom-relieving behavior therapies and medications. However, there are differences in sex ratios, patterns of comorbidity, and the results of neuroimaging studies that might be important. Here we review the diagnosis and treatment of childhood-onset OCD in light of pediatric and adult studies. We also discuss current knowledge of the pathophysiology of the disorder. Despite advances in this area, further research is needed to understand better the etiopathogenesis of the disorder and to develop new, more effective therapeutic options.
C1 [Kalra, Simran K.; Swedo, Susan E.] NIMH, Pediat Neuropsychiat Branch, NIH, Bethesda, MD 20892 USA.
RP Kalra, SK (reprint author), NIMH, Pediat Neuropsychiat Branch, NIH, 10 Ctr Dr,Rm 4N208, Bethesda, MD 20892 USA.
EM swedos@mail.nih.gov
NR 125
TC 27
Z9 28
U1 6
U2 12
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD APR
PY 2009
VL 119
IS 4
BP 737
EP 746
DI 10.1172/JCI37563
PG 10
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 428EF
UT WOS:000264830100009
PM 19339765
ER
PT J
AU Kansara, M
Tsang, M
Kodjabachian, L
Sims, NA
Trivett, MK
Ehrich, M
Dobrovic, A
Slavin, J
Choong, PFM
Simmons, PJ
Dawid, IB
Thomas, DM
AF Kansara, Maya
Tsang, Michael
Kodjabachian, Laurent
Sims, Natalie A.
Trivett, Melanie K.
Ehrich, Mathias
Dobrovic, Alexander
Slavin, John
Choong, Peter F. M.
Simmons, Paul J.
Dawid, Igor B.
Thomas, David M.
TI Wnt inhibitory factor 1 is epigenetically silenced in human
osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in
mice
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID TERMINAL OSTEOBLAST DIFFERENTIATION; RECEPTOR-RELATED PROTEIN-5; DE-NOVO
METHYLATION; FACTOR-I; PARATHYROID-HORMONE; BETA-CATENIN; SIGNALING
PATHWAY; BONE-FORMATION; GENE-EXPRESSION; CPG METHYLATION
AB Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies being developed for osteoporosis. These strategies include derepression of Wnt signaling by targeting secreted Wnt pathway antagonists, such as sclerostin. However, such therapies are associated with safety concerns regarding an increased risk of osteosarcoma, the most common primary malignancy of bone. Here, we analyzed 5 human osteosarcoma cell lines in a high-throughput screen for epigenetically silenced tumor suppressor genes and identified Wnt inhibitory factor 1 (WIF1), which encodes an endogenous secreted Wnt pathway antagonist, as a candidate tumor suppressor gene. In vitro, WIF1 suppressed P-catenin levels in human osteosarcoma cell lines, induced differentiation of human and mouse primary osteoblasts, and suppressed the growth of mouse and human osteosarcoma. cell Lines. Wif1 was highly expressed in the developing and mature mouse skeleton, and, although it was dispensable for normal development, targeted deletion of mouse Wif1 accelerated development of radiation-induced osteosarcomas in vivo. In primary human osteosarcomas, silencing of WIF1 by promoter hypermethylation was associated with loss of differentiation, increased P-catenin levels, and increased proliferation. These data lead us to suggest that derepression of Writ signaling by targeting secreted Wnt antagonists in osteoblasts may increase susceptibility to osteosarcoma.
C1 [Kansara, Maya; Trivett, Melanie K.; Dobrovic, Alexander; Simmons, Paul J.; Thomas, David M.] Peter MacCallum Canc Ctr, Ian Potter Fdn, Ctr Canc Genet & Preventat Med, Melbourne, Vic, Australia.
[Kansara, Maya; Trivett, Melanie K.; Dobrovic, Alexander; Simmons, Paul J.; Thomas, David M.] Peter MacCallum Canc Ctr, Sir Donald & Lady Trescowthick Labs, Melbourne, Vic 3002, Australia.
[Tsang, Michael; Kodjabachian, Laurent; Dawid, Igor B.] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA.
[Sims, Natalie A.; Slavin, John; Choong, Peter F. M.] St Vincents Hosp, Melbourne, Vic, Australia.
[Ehrich, Mathias] SEQUENOM Inc, San Diego, CA USA.
RP Thomas, DM (reprint author), Peter MacCallum Canc Ctr, Ian Potter Fdn, Ctr Canc Genom & Predict Med, St Andrews Pl, Melbourne, Vic 3002, Australia.
EM david.thomas@petermac.org
RI TSANG, Michael/E-2758-2013; Choong, Peter/F-1109-2014; Tsang,
Michael/I-9305-2014;
OI Dobrovic, Alexander/0000-0003-3414-112X; TSANG,
Michael/0000-0001-6384-2422; Choong, Peter/0000-0002-3522-7374; Tsang,
Michael/0000-0001-7123-0063; Ehrich, Mathias/0000-0001-8415-0310; Sims,
Natalie/0000-0003-1421-8468
FU National Health and Medical Research Council [350432, 508982]; Cancer
Council Victoria; Sarcoma Foundation of America; NICHD, NIH
FX The authors would like to thank colleagues in the Bowtell and Thomas
laboratories for helpful discussions and Alexander Grinberg, Andreas
Tomac, Heiner Westphal, Martha Rebbert, and Paul Love for help in
generating gene-modified mice. We thank Carleen Cullinane and staff for
PET scanning of the mice. This work was supported by grants 350432 and
508982 from the National Health and Medical Research Council, by the
Cancer Council Victoria, by the Sarcoma Foundation of America, by and
the intramural Research Program of the NICHD, NIH. D.M. Thomas was
supported by R.D. Wright Career Development Award 2003-7 and by
Victorian Cancer Agency Clinician Researcher Fellowship 2008-10.
NR 69
TC 157
Z9 168
U1 1
U2 13
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD APR
PY 2009
VL 119
IS 4
BP 837
EP 851
DI 10.1172/JCI37175
PG 15
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 428EF
UT WOS:000264830100022
PM 19307728
ER
PT J
AU Passeron, T
Valencia, JC
Namiki, T
Vieira, WD
Passeron, H
Miyamura, Y
Hearing, VJ
AF Passeron, Thierry
Valencia, Julio C.
Namiki, Takeshi
Vieira, Wilfred D.
Passeron, Helene
Miyamura, Yoshinori
Hearing, Vincent J.
TI Upregulation of SOX9 inhibits the growth of human and mouse melanomas
and restores their sensitivity to retinoic acid
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID HYDANTOIN PROSTAGLANDIN ANALOG; TRANSCRIPTION FACTOR SOX9; AUTOSOMAL SEX
REVERSAL; CELL-CYCLE; CAMPOMELIC DYSPLASIA; EXPRESSION; GENE; ANTIGEN;
LINES; DIFFERENTIATION
AB Treatments for primary and metastatic melanomas are rarely effective. Even therapeutics such as retinoic acid (RA) that are successfully used to treat several other forms of cancer are ineffective. Recent evidence indicates that the antiproliferative effects of RA are mediated by the transcription factor SOX9 in human cancer cell lines. As we have previously shown that SOX9 is expressed in normal melanocytes, here we investigated SOX9 expression and function in human melanomas. Although SOX9 was expressed in normal human skin, it was increasingly downregulated as melanocytes progressed to the premalignant and then the malignant and metastatic states. Overexpression of SOX9 in both human and mouse melanoma cell lines induced cell cycle arrest by increasing p21 transcription and restored sensitivity to RA by downregulating expression of PRAME, a melanoma antigen. Furthermore, SOX9 overexpression in melanoma cell lines inhibited tumorigenicity both in mice and in a human ex vivo model of melanoma. Treatment of melanoma cell lines with PGD2 increased SOX9 expression and restored sensitivity to RA. Thus, combined treatment with PGD2 and RA substantially decreased tumor growth in human ex vivo and mouse in vivo.models of melanoma. The results of our experiments targeting SOX9 provide insight into the pathophysiology of melanoma. Further, the effects of SOX9 on melanoma cell proliferation and RA sensitivity suggest the encouraging possibility of a noncytotoxic approach to the treatment of melanoma.
C1 [Passeron, Thierry; Valencia, Julio C.; Namiki, Takeshi; Vieira, Wilfred D.; Passeron, Helene; Miyamura, Yoshinori; Hearing, Vincent J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Hearing, VJ (reprint author), NCI, Cell Biol Lab, NIH, Bldg 37,Room 2132,MSC 4256, Bethesda, MD 20892 USA.
EM hearingv@nih.gov
OI Passeron, Thierry/0000-0002-0797-6570
FU NIH; National Cancer Institute
FX This research was supported by the Intramural Research Program of the
NIH, National Cancer Institute. We thank Sergio C. Coelho for providing
sections of human skin and Michael M. Gottesman and Douglas M. Lowy For
helpful discussions about the study and manuscript.
NR 31
TC 63
Z9 65
U1 0
U2 4
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD APR
PY 2009
VL 119
IS 4
BP 954
EP 963
DI 10.1172/JCI34015
PG 10
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 428EF
UT WOS:000264830100032
PM 19273910
ER
PT J
AU Huckabee, CM
Huskins, WC
Murray, PR
AF Huckabee, Charmaine M.
Huskins, W. Charles
Murray, Patrick R.
TI Predicting Clearance of Colonization with Vancomycin-Resistant
Enterococci and Methicillin-Resistant Staphylococcus aureus by Use of
Weekly Surveillance Cultures
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID DURATION; CARRIAGE; SHEA
AB We analyzed surveillance cultures for vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) collected during a multicenter trial to determine if three negative cultures collected at weekly intervals would predict clearance of VRE or MRSA from colonized patients. Seventy-two percent of VRE-colonized patients and 94% of MRSA-colonized patients were culture negative after three consecutive negative cultures.
C1 [Murray, Patrick R.] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA.
[Huckabee, Charmaine M.] Rho Fed Syst Div Inc, Chapel Hill, NC USA.
[Huskins, W. Charles] Coll Med, Mayo Clin, Rochester, MN USA.
RP Murray, PR (reprint author), NIH, Ctr Clin, Dept Lab Med, 10 Ctr Dr,Room 2C385, Bethesda, MD 20892 USA.
EM pmurray@cc.nih.gov
OI Huskins, W. Charles/0000-0002-9989-175X
FU National Institute of Allergy and Infectious Diseases, NIH [N01
AI-15440, N01 AI-15441]; Mayo Clinic Center for Translational Science
Activities [M01-RR-00585, UL1-RR024150]
FX This study was supported in part by federal funds from the National
Institute of Allergy and Infectious Diseases, NIH, under contract
numbers N01 AI-15440 and N01 AI-15441. Additional support for this study
was provided by the Mayo Clinic Center for Translational Science
Activities (M01-RR-00585 and UL1-RR024150).
NR 16
TC 6
Z9 8
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2009
VL 47
IS 4
BP 1229
EP 1230
DI 10.1128/JCM.02424-08
PG 2
WC Microbiology
SC Microbiology
GA 427RS
UT WOS:000264797000055
PM 19244462
ER
PT J
AU Kloos, RT
Ringel, MD
Knopp, MV
Hall, NC
King, M
Stevens, R
Liang, JC
Wakely, PE
Vasko, VV
Saji, M
Rittenberry, J
Wei, L
Arbogast, D
Collamore, M
Wright, JJ
Grever, M
Shah, MH
AF Kloos, Richard T.
Ringel, Matthew D.
Knopp, Michael V.
Hall, Nathan C.
King, Mark
Stevens, Robert
Liang, Jiachao
Wakely, Paul E., Jr.
Vasko, Vasyl V.
Saji, Motoyasu
Rittenberry, Jennifer
Wei, Lai
Arbogast, Daria
Collamore, Minden
Wright, John J.
Grever, Michael
Shah, Manisha H.
TI Phase II Trial of Sorafenib in Metastatic Thyroid Cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article; Proceedings Paper
CT 42nd Annual Meeting of the American-Society-of-Clinical-Oncology
CY JUN 02-06, 2006
CL Atlanta, GA
SP Amer Soc Clin Oncol
ID ENDOTHELIAL GROWTH-FACTOR; BRAF MUTATIONS; PAPILLARY CARCINOMAS; SOLID
TUMORS; RET/PTC; VEGF; ANGIOGENESIS; EXPRESSION; INHIBITORS; THERAPY
AB Purpose
Based on the pivotal role of Ras-Raf-MAP-ERK signaling and vascular endothelial growth factor (VEGF) in papillary thyroid cancer (PTC), we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC.
Patients and Methods
The primary end point was the objective response rate. Secondary end points included response correlation with serum thyroglobulin (Tg); functional imaging; tumor genotype; and signaling inhibition in tumor biopsies. Using a Simon minimax two-stage design, 16 or 25 chemotherapynaive metastatic PTC patients were to be enrolled in arm A (accessible tumor for biopsy). Arm B patients had other subtypes of thyroid carcinoma or prior chemotherapy, and did not require tumor biopsies. Patients received 400 mg orally twice per day of sorafenib. Response was assessed every 2 months using RECIST (Response Evaluation Criteria in Solid Tumors).
Results
Of 41 PTC patients, six patients had a partial response (PR; 15%; 95% CI, 6 to 29) and 23 patients (56%; 95% CI, 40 to 72) had stable disease longer than 6 months. Median duration of PR was 7.5 months (range, 6 to 14). Median progression-free survival was 15 months (95% CI, 10 to 27.5). In 14 (78%) of 18 Tg-assessable PTC patients, Tg declined more than 25%. Common grade 3 adverse events included hand-foot skin reaction, musculoskeletal pain, and fatigue. BRAF mutation was detected in 17 (77%) of 22 PTCs analyzed. Four of 10 paired tumor biopsies from PTC patients showed a reduction in levels of vascular endothelial growth factor receptor phosphorylation, ERK phosphorylation, and in VEGF expression during sorafenib therapy. No PRs were noted among non-PTC patients.
Conclusion
Sorafenib is reasonably well-tolerated therapy with clinical and biologic antitumor activity in metastatic PTC.
C1 Ohio State Univ, Dept Internal Med, Ctr Biostat, Columbus, OH 43210 USA.
Ohio State Univ, Dept Mol Virol, Ctr Biostat, Columbus, OH 43210 USA.
Ohio State Univ, Dept Immunol, Ctr Biostat, Columbus, OH 43210 USA.
Ohio State Univ, Dept Genet, Ctr Biostat, Columbus, OH 43210 USA.
Ohio State Univ, Dept Pathol, Ctr Biostat, Columbus, OH 43210 USA.
Ohio State Univ, Dept Radiol, Ctr Biostat, Columbus, OH 43210 USA.
Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
Uniformed Serv Univ Hlth Sci, Ctr Therapy & Evaluat Program, Natl Canc Inst, Bethesda, MD 20814 USA.
RP Shah, MH (reprint author), A438 Starling Loving Hall,320 W 10th Ave, Columbus, OH 43210 USA.
EM manisha.shah@osumc.edu
FU NCI NIH HHS [N01 CM57018, U01 CA076576, U01 CA76576, R21 CA112903]
NR 33
TC 310
Z9 322
U1 0
U2 10
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD APR 1
PY 2009
VL 27
IS 10
BP 1675
EP 1684
DI 10.1200/JCO.2008.18.2717
PG 10
WC Oncology
SC Oncology
GA 447MB
UT WOS:000266194100024
PM 19255327
ER
PT J
AU Korn, EL
Freidlin, B
Mooney, M
AF Korn, Edward L.
Freidlin, Boris
Mooney, Margaret
TI Stopping or Reporting Early for Positive Results in Randomized Clinical
Trials: The National Cancer Institute Cooperative Group Experience From
1990 to 2005
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID PHASE-III TRIAL; ACUTE LYMPHOBLASTIC-LEUKEMIA; THALIDOMIDE PLUS
DEXAMETHASONE; SUBTOTAL LYMPHOID IRRADIATION; METASTATIC
COLORECTAL-CANCER; CHRONIC LYMPHOCYTIC-LEUKEMIA; DIAGNOSED
MULTIPLE-MYELOMA; RISK CERVICAL-CANCER; ONCOLOGY-GROUP TRIAL; CELL
LUNG-CANCER
AB Randomized clinical trials are designed with stopping boundaries to guide data monitoring committees with their decision making concerning ongoing trials. In particular, when extremely positive results are seen and a boundary is crossed, the data monitoring committee may recommend releasing the results earlier to the public than at the definitive final analysis time specified in the protocol. For trials that are still accruing, this also means stopping accrual. Because the information about treatment efficacy is more limited in an early analysis than in a final analysis, questions have been raised about the appropriateness of incorporating early stopping for positive results in trial designs. In particular, there are concerns that treatment effects seen early may not be real or may be overly optimistic. To examine this issue, we collected information about treatment efficacy on National Cancer Institute Cooperative Group trials that were stopped early for positive results (information both at the time the trial was stopped/released and at times of further follow-up). Twenty-seven such trials were located. For 17 of 18 of these trials with sufficient follow-up information, the treatment effect was similar or only slightly smaller at last follow-up compared with the stopping/release time. We critically evaluate reasons why one might be concerned about early stopping for positive results. We conclude that for trials with well-designed interim monitoring plans, the ability to stop early for positive results is an important component of the trial design, allowing the public to benefit as soon as possible from the study conclusions. J Clin Oncol 27:1712-1721. Published by the American Society of Clinical Oncology
C1 [Korn, Edward L.] NCI, Biometr Res Branch, Bethesda, MD 20892 USA.
NCI, Clin Invest Branch, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
RP Korn, EL (reprint author), NCI, Biometr Res Branch, EPN-8129, Bethesda, MD 20892 USA.
EM korne@ctep.nci.nih.gov
NR 75
TC 23
Z9 23
U1 0
U2 1
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD APR 1
PY 2009
VL 27
IS 10
BP 1712
EP 1721
DI 10.1200/JCO.2008.19.5339
PG 10
WC Oncology
SC Oncology
GA 447MB
UT WOS:000266194100028
PM 19237631
ER
PT J
AU Salvatore, P
Baldessarini, RJ
Tohen, M
Khalsa, HMK
Sanchez-Toledo, JP
Zarate, CA
Vieta, E
Maggini, C
AF Salvatore, Paola
Baldessarini, Ross J.
Tohen, Mauricio
Khalsa, Hari-Mandir K.
Sanchez-Toledo, Jesus Perez
Zarate, Carlos A., Jr.
Vieta, Eduard
Maggini, Carlo
TI McLean-Harvard International First-Episode Project: Two-Year Stability
of DSM-IV Diagnoses in 500 First-Episode Psychotic Disorder Patients
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID SCHIZOAFFECTIVE DISORDER; FOLLOW-UP; SCHIZOPHRENIA; EPIDEMIOLOGY;
VALIDITY; SYSTEMS; COHORT; PSYCHOPATHOLOGY; PERSONALITY; PREVALENCE
AB Objective: Since stability of DSM-IV diagnoses of disorders with psychotic features requires validation, we evaluated psychotic patients followed systematically in the McLean-Harvard International First Episode Project.
Method: We diagnosed 517 patients hospitalized in a first psychotic illness by SCID-based criteria at baseline and at 24 months to assess stability of specific DSM-IV diagnoses.
Results: Among 500 patients (96.7%) completing the study, diagnoses remained stable in 77.6%, ranking as follows: bipolar I disorder (96.5%) > schizophrenia (75.0%) > delusional disorder (72.7%) > major depressive disorder (MDD), severe, with psychotic features (70.1%) > brief psychotic disorder (61.1%) > psychotic disorder not otherwise specified (NOS) (51.5%) >> schizophreniform disorder (10.5%). Most changed diagnoses (22.4% of patients) were to schizoaffective disorder (53.6% of changes in 12.0% of subjects, from psychotic disorder NOS > schizophrenia > schizophreniform disorder = bipolar I disorder most recent episode mixed, severe, with psychotic features > MDD, severe, with psychotic features > delusional disorder > brief psychotic disorder > bipolar I disorder most recent episode manic, severe, with psychotic features). Second most changed diagnoses were to bipolar I disorder (25.9% of changes, 5.8% of subjects, from MDD, severe, with psychotic features > psychotic disorder NOS > brief psychotic disorder > schizophreniform disorder). Third most changed diagnoses were to schizophrenia (12.5% of changes, 2.8% of subjects, from schizophreniform disorder > psychotic disorder NOS > brief psychotic disorder = delusional disorder = MDD, severe, with psychotic features). These 3 categories accounted for 92.0% of changes. By logistic regression, diagnostic change was associated with nonaffective psychosis > auditory hallucinations > youth > male sex > gradual onset.
Conclusions: Bipolar I disorder and schizophrenia were more stable diagnoses than delusional disorder or MDD, severe, with psychotic features, and much more than brief psychotic disorder, psychotic-disorder NOS, or schizophreniform disorder. Diagnostic changes mainly involved emergence of affective symptoms and were predicted by several premorbid factors. The findings have implications for revisions of DSM and ICD.
C1 [Salvatore, Paola; Baldessarini, Ross J.; Tohen, Mauricio; Khalsa, Hari-Mandir K.; Sanchez-Toledo, Jesus Perez; Zarate, Carlos A., Jr.; Vieta, Eduard; Maggini, Carlo] McLean Hosp, Mailman Res Ctr, Int Consortium Bipolar & Psychot Disorders Res, Belmont, MA 02478 USA.
[Salvatore, Paola; Baldessarini, Ross J.; Tohen, Mauricio; Khalsa, Hari-Mandir K.; Vieta, Eduard] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Salvatore, Paola; Baldessarini, Ross J.; Tohen, Mauricio; Khalsa, Hari-Mandir K.; Vieta, Eduard] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA.
[Salvatore, Paola; Maggini, Carlo] Univ Parma, Dept Neurosci, Sect Psychiat, I-43100 Parma, Italy.
[Tohen, Mauricio] Lilly Res Labs, Indianapolis, IN USA.
[Sanchez-Toledo, Jesus Perez] Univ Cambridge, Dept Psychiat, Cambridge CB2 1TN, England.
[Zarate, Carlos A., Jr.] NIMH, Lab Mol Pathophysiol & Expt Therapeut, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
[Vieta, Eduard] Univ Barcelona, Hosp Clin, Inst Neurosci, IDIBAPS,CIBERSAM, Barcelona, Spain.
RP Salvatore, P (reprint author), McLean Hosp, Mailman Res Ctr, Int Consortium Bipolar & Psychot Disorders Res, Ctr Bldg G-07B,115 Mill St, Belmont, MA 02478 USA.
EM psalvatore@mclean.harvard.edu
RI Vieta, Eduard/I-6330-2013
OI Vieta, Eduard/0000-0002-0548-0053
FU Intramural NIH HHS [Z99 MH999999]; NIMH NIH HHS [MH-73049, MH-04844,
MH-10948, MH-47370, R03 MH073049]
NR 53
TC 80
Z9 83
U1 3
U2 7
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD APR
PY 2009
VL 70
IS 4
BP 458
EP 466
PG 9
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 438IX
UT WOS:000265550200003
PM 19200422
ER
PT J
AU Lungu, C
Aia, PG
Shih, LC
Esper, CD
Factor, SA
Tarsy, D
AF Lungu, Codrin
Aia, Pratibha G.
Shih, Ludy C.
Esper, Christine D.
Factor, Stewart A.
Tarsy, Daniel
TI Tardive Dyskinesia Due to Aripiprazole Report of 2 Cases
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Letter
ID ATYPICAL ANTIPSYCHOTICS; HALOPERIDOL; ADULTS; RATES
C1 [Lungu, Codrin] NINDS, NIH, Bethesda, MD 20892 USA.
[Aia, Pratibha G.; Esper, Christine D.; Factor, Stewart A.] Emory Univ, Sch Med, Atlanta, GA USA.
[Shih, Ludy C.; Tarsy, Daniel] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
RP Lungu, C (reprint author), NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM lunguci@ninds.nih.gov
NR 17
TC 13
Z9 13
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD APR
PY 2009
VL 29
IS 2
BP 185
EP 186
PG 2
WC Pharmacology & Pharmacy; Psychiatry
SC Pharmacology & Pharmacy; Psychiatry
GA 420BO
UT WOS:000264263600016
PM 19512985
ER
PT J
AU Uhlenhaut, C
Cohen, JI
Fedorko, D
Nanda, S
Krause, PR
AF Uhlenhaut, Christine
Cohen, Jeffrey I.
Fedorko, Daniel
Nanda, Santosh
Krause, Philip R.
TI Use of a universal virus detection assay to identify human
metapneumovirus in a hematopoietic stem cell transplant recipient with
pneumonia of unknown origin
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Virus discovery; Virus detection; Immunocompromised host; Virus disease
diagnosis; Virus disease etiology
ID IDENTIFICATION; CORONAVIRUS; MICROARRAY; PATHOGENS; PCR
AB Background: Development of uncommon vital infections in immunocompromised transplant recipients can pose major diagnostic challenges. We present a case report of an immunocompromised patient Suffering from pneumonia, for which the causative agent was not identified by routine methods.
Objectives: To identify the potential cause of the pneumonia using a degenerate oligonucleotide primer (DOP)-PCR assay that is designed to detect all viruses.
Study design: DOP-PCR was applied to bronchoalveolar lavage fluid from this patient. Generic PCR products were cloned and sequenced.
Results: The novel universal virus assay detected human metapneumovirus in the clinical sample. The finding was confirmed by two independent metapneumovirus specific PCRs targeting different regions of the vital genome.
Conclusions: The DOP-PCR Was used to detect and identify the sequence of an unidentified virus. This Study provides proof of concept for the use of clinically relevant specimens in this unbiased universal assay, which requires no previous viral sequence information. Published by Elsevier B.V.
C1 [Uhlenhaut, Christine; Nanda, Santosh; Krause, Philip R.] US FDA, Ctr Biol Evaluat & Res, Div Viral Prod, Bethesda, MD 20892 USA.
[Cohen, Jeffrey I.] NIAID, Med Virol Sect, Clin Invest Lab, NIH, Bethesda, MD 20892 USA.
[Fedorko, Daniel] NIH, Microbiol Lab, Ctr Clin, Bethesda, MD 20892 USA.
RP Krause, PR (reprint author), US FDA, Ctr Biol Evaluat & Res, Div Viral Prod, Bldg 29A,Room 1C16,HFM 457,29 Lincoln Dr, Bethesda, MD 20892 USA.
EM philip.krause@fda.hhs.gov
OI Krause, Philip/0000-0002-1045-7536
FU National Institute of Allergy and Infectious Diseases; National
Institutes of Health Clinical Center
FX This study was supported by the intramural research programs of the
National Institute of Allergy and Infectious Diseases and the National
Institutes of Health Clinical Center. We gratefully acknowledge the
FDA/CBER core facility for sequencing. We also thank Dr. Shuang Tang,
Dr. Shasta McClenahan and Amita Patel for helpful comments.
NR 15
TC 6
Z9 7
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
J9 J CLIN VIROL
JI J. Clin. Virol.
PD APR
PY 2009
VL 44
IS 4
BP 337
EP 339
DI 10.1016/j.jcv.2009.01.011
PG 3
WC Virology
SC Virology
GA 436WL
UT WOS:000265446700018
PM 19250860
ER
PT J
AU Marsh, AA
Blair, KS
Jones, MM
Soliman, N
Blair, RJR
AF Marsh, Abigail A.
Blair, Karina S.
Jones, Matthew M.
Soliman, Niveen
Blair, R. J. R.
TI Dominance and Submission: The Ventrolateral Prefrontal Cortex and
Responses to Status Cues
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Article
ID DISSOCIABLE NEURAL RESPONSES; HUMAN ORBITOFRONTAL CORTEX;
FRONTAL-CORTEX; REPRODUCTIVE SUCCESS; FACIAL EXPRESSIONS;
SOCIAL-PERCEPTION; HUMAN BRAIN; SYSTEMS; GAZE; FACE
AB Status hierarchies constitute a fundamental organizing principle of human society. However, little is known about the neural systems that process nonverbal cues that indicate status. Preliminary neuropsychological work has suggested a role for the ventrolateral and ventromedial prefrontal cortex (VLPFC/VMPFC) and the superior temporal cortex (STC). We used functional magnetic resonance imaging to delineate the nature of these roles. Analyses revealed signal changes in the right VLPFC in connection with two primary functions attributed to status cues. Status cues moderate behavior and the right VLPFC showed increased signal for high-status relative to neutral and low-status cues. The VLPFC also showed increased signal for high-status cues displayed by individuals of the opposite gender to the perceiver; this may be relevant to the role status cues play in moderating mate choice behavior. Connectivity results indicated significant positive connectivity between the VLPFC and both the VMPFC and the STC. We suggest that the VLPFC retrieves information from these regions when processing hierarchy cues to facilitate socially adaptive behavior.
C1 [Marsh, Abigail A.] NIMH, Mood & Anxiety Program, Natl Inst Hlth, Bethesda, MD 20892 USA.
RP Marsh, AA (reprint author), NIMH, Mood & Anxiety Program, Natl Inst Hlth, 15k N Dr, Bethesda, MD 20892 USA.
EM amarsh@post.harvard.edu
FU National Institutes of Health
FX This research was supported by the Intramural Research Program of the
National Institutes of Health: National Institute of Mental Health. The
authors thank Ellen Condon and Elizabeth Finger for their assistance
with data collection, and the anonymous reviewers of this article for
their helpful comments.
NR 56
TC 39
Z9 40
U1 0
U2 17
PU M I T PRESS
PI CAMBRIDGE
PA 238 MAIN STREET, STE 500, CAMBRIDGE, MA 02142-1046 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PD APR
PY 2009
VL 21
IS 4
BP 713
EP 724
DI 10.1162/jocn.2009.21052
PG 12
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 421LF
UT WOS:000264359700008
PM 18578604
ER
PT J
AU Stojmirovic, A
Yu, YK
AF Stojmirovic, Aleksandar
Yu, Yi-Kuo
TI Geometric Aspects of Biological Sequence Comparison
SO JOURNAL OF COMPUTATIONAL BIOLOGY
LA English
DT Article
DE algorithms; alignment; distance geometry; dynamic programming
ID ACID SUBSTITUTION MATRICES; HIDDEN MARKOV-MODELS; SIMILARITY SEARCH;
PROTEIN SEQUENCES; INDEXING SCHEMES; METRIC-SPACES; TWILIGHT ZONE;
ALIGNMENT; DATABASE; ALGORITHM
AB We introduce a geometric framework suitable for studying the relationships among biological sequences. In contrast to previous works, our formulation allows asymmetric distances (quasi-metrics), originating from uneven weighting of strings, which may induce non-trivial partial orders on sets of biosequences. The distances considered are more general than traditional generalized string edit distances. In particular, our framework enables non-trivial conversion between sequence similarities, both local and global, and distances. Our constructions apply to a wide class of scoring schemes and require much less restrictive gap penalties than the ones regularly used. Numerous examples are provided to illustrate the concepts introduced and their potential applications.
C1 [Stojmirovic, Aleksandar; Yu, Yi-Kuo] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
RP Yu, YK (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, 8600 Rockville Pike, Bethesda, MD 20894 USA.
EM yyu@ncbi.nlm.nih.gov
OI Stojmirovic, Aleksandar/0000-0003-0957-6893
FU University of Ottawa; National Library of Medicine at National
Institutes of Health
FX A. S. is very grateful to his Ph. D. and postdoctoral supervisor,
Vladimir Pestov, who read and commented on the early versions of this
manuscript. A. S. was supported by University of Ottawa research funds.
This work was supported by the Intramural Research Program of the
National Library of Medicine at National Institutes of Health.
NR 87
TC 3
Z9 3
U1 0
U2 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1066-5277
J9 J COMPUT BIOL
JI J. Comput. Biol.
PD APR
PY 2009
VL 16
IS 4
BP 579
EP 610
DI 10.1089/cmb.2008.0100
PG 32
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Computer Science, Interdisciplinary Applications; Mathematical &
Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Computer Science; Mathematical & Computational Biology; Mathematics
GA 438JJ
UT WOS:000265551400005
PM 19361329
ER
PT J
AU Koutlas, IG
Koch, CA
Vickers, RA
Brouwers, FM
Vortmeyer, AO
AF Koutlas, Ioannis G.
Koch, Christian A.
Vickers, Robert A.
Brouwers, Frederieke M.
Vortmeyer, Alexander O.
TI An unusual ostensible example of intraoral basal cell carcinoma
SO JOURNAL OF CUTANEOUS PATHOLOGY
LA English
DT Article
ID PERIPHERAL AMELOBLASTOMA; MONOCLONAL-ANTIBODY; SONIC-HEDGEHOG; ORAL
CAVITY; BER-EP4; GINGIVA; MUCOSA; SKIN; EXPRESSION; CALRETININ
AB An example of oral basal cell carcinoma is presented originating on the posterior mandibular mucosa and gingiva of a 67-year-old female. Histologically, it featured a multifocal pattern. It recurred eight times in a period of 20 years. Tissue samples of the tumor were evaluated with monoclonal antibody Ber-EP4 and were compared with examples of oral mucosa, skin, oral and cutaneous squamous cell carcinoma, peripheral ameloblastoma, ameloblastoma and cutaneous basal cell carcinoma (BCC). Only neoplastic basal cells showed positive immunohistochemical staining. Additionally, microdissected neoplastic areas were evaluated for loss of heterozygosity (LOH) of the PTCH gene with markers D9S303, D9S252 and D9S287. PTCH gene mutations are reported in patients with Gorlin syndrome and sporadic cutaneous BCCs. Loss of one allele was observed with all three markers. Examples of conventional ameloblastomas did not show evidence of LOH. These observations support the inclusion of BCC in the differential diagnosis of appropriate oral mucosal neoplasms.
Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma.J Cutan Pathol 2009; 36: 464-470. (C) 2008 Blackwell Munksgaard.
C1 [Koutlas, Ioannis G.; Vickers, Robert A.] Univ Minnesota, Dept Oral & Maxillofacial Pathol, Sch Dent, Minneapolis, MN 55455 USA.
[Koch, Christian A.] Univ Mississippi, Div Endocrinol, Dept Med, Jackson, MS 39216 USA.
[Brouwers, Frederieke M.] NICHHD, Pediat & Reprod Endocrinol Branch, NH, Bethesda, MD 20892 USA.
[Vortmeyer, Alexander O.] NINDS, Mol Pathogenesis Lab, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
RP Koutlas, IG (reprint author), Univ Minnesota, Dept Oral & Maxillofacial Pathol, Sch Dent, 515 Delaware St SE 16-206B, Minneapolis, MN 55455 USA.
EM koutl001@umn.edu
RI Koch, Christian/A-4699-2008;
OI Koch, Christian/0000-0003-3127-5739; Koch, Christian/0000-0003-0678-1242
NR 48
TC 7
Z9 7
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0303-6987
J9 J CUTAN PATHOL
JI J. Cutan. Pathol.
PD APR
PY 2009
VL 36
IS 4
BP 464
EP 470
DI 10.1111/j.1600-0560.2008.01059.x
PG 7
WC Dermatology; Pathology
SC Dermatology; Pathology
GA 412WD
UT WOS:000263754000012
PM 19278434
ER
PT J
AU Hatakeyama, J
Fukumoto, S
Nakamura, T
Haruyama, N
Suzuki, S
Hatakeyama, Y
Shum, L
Gibson, CW
Yamada, Y
Kulkarni, AB
AF Hatakeyama, J.
Fukumoto, S.
Nakamura, T.
Haruyama, N.
Suzuki, S.
Hatakeyama, Y.
Shum, L.
Gibson, C. W.
Yamada, Y.
Kulkarni, A. B.
TI Synergistic Roles of Amelogenin and Ameloblastin
SO JOURNAL OF DENTAL RESEARCH
LA English
DT Article
DE enamel; amelogenin; ameloblastin; knockout mice; RhoGDI (Arhgdia)
ID ACTIN CYTOSKELETON; RHO-GTPASES; EPITHELIAL-CELLS; ENAMEL DEFECTS;
IMPERFECTA; MICE; DIFFERENTIATION; MATRIX; GENE; LOCALIZATION
AB Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-/-)/Ambn(-/-) mice, not only was the ameloblast layer irregular and detached from the enamel surface, as in Ambn(-/-), but also, the enamel width was significantly reduced in the double-null mice as compared with Amel X(-/-) or Ambn(-/-) mice. Proteomic analysis of the double-null teeth revealed increased levels of RhoGDI (Arhgdia), a Rho-family-specific guanine nucleotide dissociation inhibitor, which is involved in important cellular processes, such as cell attachment. Both Amel X(-/-)/Ambn(-/-) mice and Ambn(-/-) mice displayed positive staining with RhoGDI antibody in the irregularly shaped ameloblasts detached from the matrix. Ameloblastin-regulated expression of RhoGDI suggests that Rho-mediated signaling pathway might play a role in enamel formation.
C1 [Hatakeyama, J.; Haruyama, N.; Suzuki, S.; Kulkarni, A. B.] Natl Inst Dent & Craniofacial Res, Funct Genom Sect, Lab Cell & Dev Biol, Bethesda, MD 20892 USA.
[Hatakeyama, Y.; Shum, L.] NIAMSD, Cartilage Biol & Orthoped Branch, NIH, Bethesda, MD 20892 USA.
[Gibson, C. W.] Univ Penn, Sch Dent Med, Dept Anat & Cell Biol, Philadelphia, PA 19104 USA.
RP Kulkarni, AB (reprint author), Natl Inst Dent & Craniofacial Res, Funct Genom Sect, Lab Cell & Dev Biol, 30 Convent Dr,MSC 4395, Bethesda, MD 20892 USA.
EM ak40m@nih.gov
RI Haruyama, Naoto/D-1993-2011; Nakamura, Takashi/P-7796-2016
OI Haruyama, Naoto/0000-0001-6225-5816; Nakamura,
Takashi/0000-0001-9904-1037
FU National Institute of Dental and Craniofacial Research
FX We thank Drs. Aya Yamada and Yoko Kamasaki for generous help with SEM
analysis, and Harry Grant for editorial assistance. This work was
supported by the Division of Intramural Research of the National
Institute of Dental and Craniofacial Research.
NR 31
TC 25
Z9 26
U1 1
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0345
J9 J DENT RES
JI J. Dent. Res.
PD APR
PY 2009
VL 88
IS 4
BP 318
EP 322
DI 10.1177/0022034509334749
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 450XF
UT WOS:000266434000004
PM 19407150
ER
PT J
AU Wright, JT
Frazier-Bowers, S
Simmons, D
Alexander, K
Crawford, P
Han, ST
Hart, PS
Hart, TC
AF Wright, J. T.
Frazier-Bowers, S.
Simmons, D.
Alexander, K.
Crawford, P.
Han, S. T.
Hart, P. S.
Hart, T. C.
TI Phenotypic Variation in FAM83H-associated Amelogenesis Imperfecta
SO JOURNAL OF DENTAL RESEARCH
LA English
DT Article
DE enamel; FAM83H; amelogenesis imperfecta; hypocalcified; phenotype;
craniofacial
ID MANDIBULAR PROGNATHISM; MUTATION; ENAMEL
AB FAM83H gene mutations are associated with autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI), which is typically characterized by enamel having normal thickness and a markedly decreased mineral content. This study tested the hypothesis that there are phenotype and genotype associations in families with FAM83H-associated ADHCAI. Seven families segregating ADHCAI (147 individuals) were evaluated. Phenotyping included clinical, radiographic, histological, and biochemical studies, and genotyping was by mutational analysis. Multiple novel FAM83H mutations were identified, including two 2-bp-deletion mutations, the first non-nonsense mutations identified. Craniofacial deviation from normal was more prevalent in the affected individuals. Affected individuals having truncating FAMH3H mutations of 677 or fewer amino acids presented a generalized ADHCAI phenotype, while those having mutations capable of producing a protein of at least 694 amino acids had a unique and previously unreported phenotype affecting primarily the cervical enamel. This investigation shows that unique phenotypes are associated with specific FAM83H mutations.
C1 [Wright, J. T.; Simmons, D.] Univ N Carolina, Sch Dent, Dept Pediat Dent, Chapel Hill, NC 27599 USA.
[Frazier-Bowers, S.; Alexander, K.] Univ N Carolina, Dept Orthodont, Chapel Hill, NC 27599 USA.
[Crawford, P.] Univ Bristol, Dept Paediat Dent, Bristol BS8 1TH, Avon, England.
[Han, S. T.; Hart, T. C.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA.
[Hart, P. S.] NHGRI, NIH, Bethesda, MD 20892 USA.
RP Wright, JT (reprint author), Univ N Carolina, Sch Dent, Dept Pediat Dent, CB 7450,Brauer Hall, Chapel Hill, NC 27599 USA.
EM tim_wright@dentistry.unc.edu
FU NIDCR [DE-12879]; National Institute of Dental and Craniofacial Research
[Z01DE000711]; National Human Genome Research Institute of the National
Institutes of Health, Bethesda, MD, USA
FX We acknowledge the participating families, Dr. Mitsuo Yamauchi for
assisting with amino acid analysis, and Wallace Ambrose's help with the
SEM and TEM. This study was supported by NIDCR Grant DE-12879 and the
Intramural Research Programs of the National Institute of Dental and
Craniofacial Research (Z01DE000711) and by the National Human Genome
Research Institute of the National Institutes of Health, Bethesda, MD,
USA. The content is solely the responsibility of the authors and does
not necessarily represent the official views of the National Institute
of Dental and Craniofacial Research or the National Institutes of
Health.
NR 22
TC 28
Z9 29
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0345
J9 J DENT RES
JI J. Dent. Res.
PD APR
PY 2009
VL 88
IS 4
BP 356
EP 360
DI 10.1177/0022034509333822
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 450XF
UT WOS:000266434000011
PM 19407157
ER
PT J
AU Deserno, TM
Antani, S
Long, R
AF Deserno, Thomas M.
Antani, Sameer
Long, Rodney
TI Ontology of Gaps in Content-Based Image Retrieval
SO JOURNAL OF DIGITAL IMAGING
LA English
DT Article
DE Content-based image retrieval (CBIR); pattern recognition; picture
archiving and communication systems (PACS); information system
integration; data mining; information retrieval; semantic gap
ID DATABASES
AB Content-based image retrieval (CBIR) is a promising technology to enrich the core functionality of picture archiving and communication systems (PACS). CBIR has a potential for making a strong impact in diagnostics, research, and education. Research as reported in the scientific literature, however, has not made significant inroads as medical CBIR applications incorporated into routine clinical medicine or medical research. The cause is often attributed (without supporting analysis) to the inability of these applications in overcoming the "semantic gap." The semantic gap divides the high-level scene understanding and interpretation available with human cognitive capabilities from the low-level pixel analysis of computers, based on mathematical processing and artificial intelligence methods. In this paper, we suggest a more systematic and comprehensive view of the concept of "gaps" in medical CBIR research. In particular, we define an ontology of 14 gaps that addresses the image content and features, as well as system performance and usability. In addition to these gaps, we identify seven system characteristics that impact CBIR applicability and performance. The framework we have created can be used a posteriori to compare medical CBIR systems and approaches for specific biomedical image domains and goals and a priori during the design phase of a medical CBIR application, as the systematic analysis of gaps provides detailed insight in system comparison and helps to direct future research.
C1 [Deserno, Thomas M.] Aachen Univ Technol RWTH, Dept Med Informat, D-52057 Aachen, Germany.
[Deserno, Thomas M.; Antani, Sameer; Long, Rodney] US Natl Inst Hlth, US Natl Lib Med, Bethesda, MD 20894 USA.
RP Deserno, TM (reprint author), Aachen Univ Technol RWTH, Dept Med Informat, Pauwelsstr 30, D-52057 Aachen, Germany.
EM deserno@ieee.org
OI Antani, Sameer/0000-0002-0040-1387
FU U.S. National Institutes of Health (NIH); U.S. National Library of
Medicine (NLM); U.S. Lister Hill National Center for Biomedical
Communications (LHNCBC)
FX This researchwas supported [in part] by the Intramural Research Program
of the U.S. National Institutes of Health (NIH), U.S. National Library
of Medicine (NLM), and the U.S. Lister Hill National Center for
Biomedical Communications (LHNCBC).
NR 32
TC 44
Z9 46
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0897-1889
EI 1618-727X
J9 J DIGIT IMAGING
JI J. Digit. Imaging
PD APR
PY 2009
VL 22
IS 2
BP 202
EP 215
DI 10.1007/s10278-007-9092-x
PG 14
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 420CC
UT WOS:000264265000011
PM 18239964
ER
PT J
AU Merikangas, KR
Conway, KP
Swendsen, J
Febo, V
Dierker, L
Brunetto, W
Stolar, M
Canino, G
AF Merikangas, K. R.
Conway, K. P.
Swendsen, J.
Febo, V.
Dierker, L.
Brunetto, W.
Stolar, M.
Canino, G.
TI Substance use and behaviour disorders in Puerto Rican youth: a migrant
family study
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID DIAGNOSTIC INTERVIEW SCHEDULE; TEST-RETEST RELIABILITY; NATIONAL
EPIDEMIOLOGIC SURVEY; IV PSYCHIATRIC-DISORDERS; ILLICIT DRUG-USE;
UNITED-STATES; MEXICAN-AMERICANS; SOCIAL-ASSIMILATION; 12-MONTH
PREVALENCE; ALCOHOL DEPENDENCE
AB Background: Hispanics in the USA have higher rates of substance use disorders than similar ethnic groups residing in Latin American nations, and recent evidence suggests an increase in substance use among US Hispanic youth. This investigation examines the familial and societal correlates of this increase by comparing Puerto Rican families residing in the mainland USA and Puerto Rico.
Methods: Using migrant and controlled family study methods, 279 probands in San Juan and 236 probands in New Haven were recruited from treatment clinics and the general community to compose four diagnostic groups: drug abuse/dependence; alcohol abuse/dependence; psychiatric controls; unaffected controls. 806 biological offspring aged 12-17 were then directly interviewed.
Results: Total rates for alcohol use were greater among San Juan Youth than their migrant counterparts. By contrast, US migrant adolescents were more likely to use cannabis. A strong association was observed between parental and child substance use at both sites, particularly for boys, and offspring of probands with drug use disorders were at greatest risk for substance use and related disorders. Familial aggregation patterns did not vary substantially by site.
Conclusions: Despite societal influences on the magnitude and patterns of substance use in migrant youth, the consistent influence of parental disorders across sites reveals that the cross-generational transmission of substance use disorders in prior studies extends to Hispanic families and is an important factor to consider in the development of prevention strategies.
C1 [Swendsen, J.] CNRS, UMR 5231, Natl Ctr Sci Res, Bordeaux, France.
[Merikangas, K. R.] NIMH, Intramural Res Programme, Bethesda, MD 20892 USA.
[Conway, K. P.] Natl Inst Drug Abuse, Div Epidemiol Serv & Prevent Res, Bethesda, MD USA.
[Febo, V.; Canino, G.] Univ San Juan, San Juan, PR USA.
[Dierker, L.] Wesleyan Univ, Dept Psychol, Middletown, CT USA.
[Brunetto, W.; Stolar, M.] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA.
RP Swendsen, J (reprint author), CNRS 5231, 146 Rue Leo Saignant, F-33076 Bordeaux, France.
EM Joel.Swendsen@u-bordeaux2.fr
OI Conway, Kevin/0000-0002-7638-339X
FU National Institutes of Health [AA07080, DA09055, MH36197, MH0049];
Intramural Research Program at the National Institute of Mental Health
FX This work was supported in part by grants AA07080, DA09055, MH36197, and
MH0049 (KRM) from the National Institutes of Health and the Intramural
Research Program at the National Institute of Mental Health.
NR 47
TC 10
Z9 10
U1 7
U2 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD APR
PY 2009
VL 63
IS 4
BP 310
EP 316
DI 10.1136/jech.2008.078048
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 420RO
UT WOS:000264307100011
PM 19147633
ER
PT J
AU Haggstrom, D
Klabunde, CN
AF Haggstrom, D.
Klabunde, C. N.
TI COLORECTAL CANCER SCREENING AMONG ELDERLY PATIENTS WITH VARYING SEVERITY
OF ILLNESS
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine
CY MAY 13-16, 2009
CL Miami, FL
SP Soc Gen Internal Med
C1 [Haggstrom, D.] VA HSR&D Ctr Implementing Evidence Based Practice, Indianapolis, IN USA.
[Klabunde, C. N.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2009
VL 24
SU 1
BP 43
EP 44
PG 2
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 435ZI
UT WOS:000265382000117
ER
PT J
AU Mcdermott, MM
Liu, K
Guralnik, JM
Ferrucci, L
Tian, L
Criqui, MH
AF Mcdermott, M. M.
Liu, K.
Guralnik, J. M.
Ferrucci, L.
Tian, L.
Criqui, M. H.
TI LEG SYMPTOM TYPE PREDICTS THE RATE OF FUNCTIONAL DECLINE IN PATIENTS
WITH PERIPHERAL ARTERIAL DISEASE: A FIVE-YEAR FOLLOW-UP STUDY
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine
CY MAY 13-16, 2009
CL Miami, FL
SP Soc Gen Internal Med
C1 [Mcdermott, M. M.; Liu, K.; Tian, L.] Northwestern Univ, Chicago, IL 60611 USA.
[Guralnik, J. M.; Ferrucci, L.] NIA, Bethesda, MD 20892 USA.
[Criqui, M. H.] Univ Calif San Diego, La Jolla, CA 92093 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2009
VL 24
SU 1
BP 115
EP 116
PG 2
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 435ZI
UT WOS:000265382000308
ER
PT J
AU Bautista, MK
Garvan, CW
Beyth, RJ
Kwoh, K
Harris, TB
Nevitt, MC
Shorr, RI
AF Bautista, M. K.
Garvan, C. W.
Beyth, R. J.
Kwoh, K.
Harris, T. B.
Nevitt, M. C.
Shorr, R. I.
TI LOW LITERACY PREDICTS UTILIZATION OF TOTAL KNEE ARTHROPLASTY IN OLDER
ADULTS WITH KNEE PAIN: FINDINGS FROM THE HEALTH, AGING AND BODY
COMPOSITION STUDY.
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine
CY MAY 13-16, 2009
CL Miami, FL
SP Soc Gen Internal Med
C1 [Bautista, M. K.; Beyth, R. J.; Shorr, R. I.] Univ Florida, Dept Aging, NF SGVHS GRECC, Gainesville, FL USA.
[Garvan, C. W.] Univ Florida, Coll Educ, Gainesville, FL USA.
[Kwoh, K.] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, CHERP, Pittsburgh, PA USA.
[Harris, T. B.] NIH, Chevy Chase, MD USA.
[Nevitt, M. C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2009
VL 24
SU 1
BP 117
EP 118
PG 2
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 435ZI
UT WOS:000265382000313
ER
PT J
AU Mcdermott, MM
Liu, K
Guralnik, JM
Ferrucci, L
Tian, L
Criqui, MH
AF Mcdermott, M. M.
Liu, K.
Guralnik, J. M.
Ferrucci, L.
Tian, L.
Criqui, M. H.
TI LOWER EXTREMITY PERONEAL NERVE FUNCTION IS ASSOCIATED WITH THE DEGREE OF
FUNCTIONAL IMPAIRMENT IN PERIPHERAL ARTERIAL DISEASE PARTICIPANTS
WITHOUT DIABETES MELLITUS
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine
CY MAY 13-16, 2009
CL Miami, FL
SP Soc Gen Internal Med
C1 [Mcdermott, M. M.; Liu, K.; Tian, L.] Northwestern Univ, Chicago, IL 60611 USA.
[Guralnik, J. M.; Ferrucci, L.] NIH, Bethesda, MD 20892 USA.
[Criqui, M. H.] Univ Calif San Diego, La Jolla, CA 92093 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2009
VL 24
SU 1
BP 118
EP 118
PG 1
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 435ZI
UT WOS:000265382000314
ER
PT J
AU Tilburt, J
Jenkins, S
Ottenberg, A
Bolcic-Jankovic, D
Clarridge, B
Kaptchuk, TJ
Miller, FG
Emanuel, E
Curlin, FA
AF Tilburt, J.
Jenkins, S.
Ottenberg, A.
Bolcic-Jankovic, D.
Clarridge, B.
Kaptchuk, T. J.
Miller, F. G.
Emanuel, E.
Curlin, F. A.
TI WHAT INFLUENCES CLINICIANS' JUDGMENTS ABOUT COMPLEMENTARY AND
ALTERNATIVE MEDICINE RESEARCH EVIDENCE: A RANDOMIZED EXPERIMENTAL
VIGNETTE STUDY
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine
CY MAY 13-16, 2009
CL Miami, FL
SP Soc Gen Internal Med
C1 [Tilburt, J.; Jenkins, S.; Ottenberg, A.] Mayo Clin, Rochester, MN USA.
[Bolcic-Jankovic, D.; Clarridge, B.] Univ Massachusetts, Boston, MA 02125 USA.
[Kaptchuk, T. J.] Harvard Univ, Sch Med, Osher Ctr, Boston, MA USA.
[Miller, F. G.; Emanuel, E.] NIH, Bethesda, MD 20892 USA.
[Curlin, F. A.] Univ Chicago, Chicago, IL 60637 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2009
VL 24
SU 1
BP 216
EP 216
PG 1
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 435ZI
UT WOS:000265382000573
ER
PT J
AU Hamilton, R
Williams, JK
Bowers, BJ
Calzone, K
AF Hamilton, Rebekah
Williams, Janet K.
Bowers, Barbara J.
Calzone, Kathleen
TI Life Trajectories, Genetic Testing, and Risk Reduction Decisions in
18-39 Year Old Women at Risk for Hereditary Breast and Ovarian Cancer
SO JOURNAL OF GENETIC COUNSELING
LA English
DT Article
DE BRCA1/2 mutation testing; Young women; Decision making; Breast cancer;
Oncology; Genetic counseling
ID BRCA2 MUTATION CARRIERS; BREAST/OVARIAN CANCER; FAMILY-HISTORY; HEALTHY
WOMEN; SUSCEPTIBILITY; ADULTHOOD; YOUNG; OOPHORECTOMY; INFORMATION;
TRANSITION
AB This qualitative study identified four life trajectories that influenced the decision in young women to have genetic testing for mutations in BRCA1/2 and subsequent risk reduction decisions after receiving a positive mutation result. Fifty nine women between the ages of 18-39 years were interviewed in this grounded theory study, 44 of those tested were found to have a mutation in either BRCA1 or BRCA2. Of those with a mutation, 23 had no history of cancer and 21 had a breast cancer diagnosis. Analysis of the 44 participants tested found that risk reducing decisions were related to the life trajectories that preceded genetic testing. These life trajectories included: 1) Long-standing awareness of breast cancer in the family, 2) Loss of one's mother to breast cancer at a young age, 3) Expression of concern by a health care provider, and 4) Personal diagnosis of breast cancer. Understanding possible influences behind decision making for genetic testing and risk reduction in young women may assist health care providers in offering age appropriate guidance and support.
C1 [Hamilton, Rebekah] Univ Illinois, Chicago, IL 60612 USA.
[Williams, Janet K.] Univ Iowa, Coll Nursing, Iowa City, IA 52242 USA.
[Bowers, Barbara J.] Univ Wisconsin, Sch Nursing, Madison, WI 53792 USA.
[Calzone, Kathleen] NCI, CCR, Genet Branch, Bethesda, MD 20889 USA.
RP Hamilton, R (reprint author), Univ Illinois, 845 S Damen Ave,M-C 820, Chicago, IL 60612 USA.
EM hamilr@uic.edu
OI Bowers, Barbara/0000-0002-3226-0718
NR 72
TC 15
Z9 15
U1 2
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-7700
J9 J GENET COUNS
JI J. Genet. Couns.
PD APR
PY 2009
VL 18
IS 2
BP 147
EP 159
DI 10.1007/s10897-008-9200-1
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 461IE
UT WOS:000267257500009
ER
PT J
AU Lee, TL
Li, YM
Alba, D
Vong, QP
Wu, SM
Baxendale, V
Rennert, OM
Lau, YFC
Chan, WY
AF Lee, Tin-Lap
Li, Yunmin
Alba, Diana
Vong, Queenie P.
Wu, Shao-Ming
Baxendale, Vanessa
Rennert, Owen M.
Lau, Yun-Fai Chris
Chan, Wai-Yee
TI Developmental staging of male murine embryonic gonad by SAGE analysis
SO JOURNAL OF GENETICS AND GENOMICS
LA English
DT Article
DE SAGE; transcriptome; male gonads gene tag; novel transcripts; cluster
analysis; chromosome; transcription hotspot
ID GENE-EXPRESSION DATA; SEX DETERMINATION REVEALS; LARGE-SCALE SCREEN;
MALE GERM-CELLS; SERIAL ANALYSIS; OVARIAN DEVELOPMENT; TESTIS
DEVELOPMENT; MICROARRAY DATA; MOUSE GONAD; DIFFERENTIATION
AB Despite the identification of key genes such as Sry integral to embryonic gonadal development, the genomic classification and identification of chromosomal activation of this process is still poorly understood. To better understand the genetic regulation of gonadal development, we performed Serial Analysis of Gene Expression (SAGE) to profile the genes and novel transcripts, and an average of 152,000 tags from male embryonic gonads at E10.5 (embryonic day 10.5), E11.5, E12.5, E13.5, E15.5 and E17.5 were analyzed. A total of 275,583 non-singleton tags that do not map to any annotated sequence were identified in the six gonad libraries, and 47,255 tags were mapped to 24,975 annotated sequences, among which 987 sequences were uncharacterized. Utilizing an unsupervised pattern identification technique, we established molecular staging of male gonadal development. Rather than providing a static descriptive analysis, we developed algorithms to cluster the SAGE data and assign SAGE tags to a corresponding chromosomal position; these data are displayed in chromosome graphic format. A prominent increase in global genomic activity from E10.5 to E17.5 was observed. Important chromosomal regions related to the developmental processes were identified and validated based on established mouse models with developmental disorders. These regions may represent markers for early diagnosis for disorders of male gonad development as well as potential treatment targets.
C1 [Lee, Tin-Lap; Alba, Diana; Vong, Queenie P.; Wu, Shao-Ming; Baxendale, Vanessa; Rennert, Owen M.; Chan, Wai-Yee] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Dev Genom, Lab Clin Genom, NIH, Bethesda, MD 20892 USA.
[Li, Yunmin; Lau, Yun-Fai Chris] Univ Calif San Francisco, Dept Med, VA Med Ctr, San Francisco, CA 94121 USA.
[Chan, Wai-Yee] Georgetown Univ, Dept Pediat Biochem Mol & Cellular Biol, Washington, DC 20007 USA.
RP Chan, WY (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Dev Genom, Lab Clin Genom, NIH, Bethesda, MD 20892 USA.
EM chanwy@mail.nih.gov
RI Lee, Tin-Lap/A-7853-2009;
OI Lee, Tin-Lap/0000-0002-6654-0988; Lau, Yun-Fai /0000-0002-9119-7050
FU National Institutes of Health (NIH); Eunice Kennedy Shriver National
Institute of Child Health and Human Development, USA; Congressionally
Directed Biomedical Research in Prostate Cancer of the Department of
Defense; Research Enhancement Award in Prostate Cancer; Department of
Veterans Affairs, USA
FX This work was supported in part by the Intramural Research Program of
the National Institutes of Health (NIH), Eunice Kennedy Shriver National
Institute of Child Health and Human Development, USA, grants from the
Congressionally Directed Biomedical Research in Prostate Cancer of the
Department of Defense, the Research Enhancement Award in Prostate
Cancer, and a Merit Award of the Department of Veterans Affairs, USA.
NR 50
TC 5
Z9 6
U1 1
U2 3
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1673-8527
J9 J GENET GENOMICS
JI J. Genet. Genomics
PD APR
PY 2009
VL 36
IS 4
BP 215
EP 227
DI 10.1016/S1673-8527(08)60109-5
PG 13
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 434GG
UT WOS:000265262600004
PM 19376482
ER
PT J
AU Lin, PT
Hallett, M
AF Lin, Peter T.
Hallett, Mark
TI The Pathophysiology of Focal Hand Dystonia
SO JOURNAL OF HAND THERAPY
LA English
DT Article
ID PRIMARY SOMATOSENSORY CORTEX; WRITERS CRAMP; INTRACORTICAL INHIBITION;
SPATIAL DISCRIMINATION; ASSOCIATIVE PLASTICITY; ABNORMALITIES;
REORGANIZATION; ACTIVATION; SYMPTOMS; REVEALS
AB Narrative Review: Focal hand dystonia is a disabling movement disorder, often task specific, that leads to impaired hand use. In addition to a genetic predisposition, environmental risk factors including repetitive use and musculoskeletal constraints are contributory. Although the underlying cause is unknown, recent studies have identified several key mechanisms that may play a part in its genesis. Failure of inhibition, abnormal sensorimotor integration, and maladaptive plasticity seen to be important. Understanding the underlying physiology may lead to the design of novel therapies. Level of Evidence: 5. I HAND THER. 2009;22:109-14.
C1 [Lin, Peter T.; Hallett, Mark] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA.
RP Lin, PT (reprint author), NINDS, Human Motor Control Sect, NIH, 10 Ctr Dr,NIH Bldg 10,Room 7D37, Bethesda, MD 20892 USA.
EM linpe@ninds.nih.gov
FU Intramural Research Program of the NIH, NINDS
FX This research was supported by the Intramural Research Program of the
NIH, NINDS.
NR 39
TC 43
Z9 44
U1 2
U2 6
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
J9 J HAND THER
JI J. Hand Ther.
PD APR-JUN
PY 2009
VL 22
IS 2
BP 109
EP 113
DI 10.1016/j.jht.2008.10.008
PG 5
WC Orthopedics; Rehabilitation; Surgery
SC Orthopedics; Rehabilitation; Surgery
GA 442TG
UT WOS:000265862900002
PM 19216051
ER
PT J
AU Croswell, JM
Kramer, BS
AF Croswell, Jennifer M.
Kramer, Barnett S.
TI Clinical trial design and evidence-based outcomes in the study of liver
diseases
SO JOURNAL OF HEPATOLOGY
LA English
DT Article; Proceedings Paper
CT 2nd Annual Conference of the International-Liver-Cancer-Association
CY SEP, 2008
CL Chicago, IL
SP Int Liver Cancer Assoc
DE Clinical design; Evidenced-based outcomes; Surrogate endpoints
ID SURROGATE END-POINTS; COLORECTAL-CANCER; RISK; COFFEE
AB Current medical training often does not include the formal study of trial design, forcing clinicians to acquire this knowledge independently. This article reviews the foundational elements of clinical trial design. An overarching hierarchy of clinical evidence is introduced, and the relative strengths and limitations of the major types of study designs are discussed. A corollary to the hierarchy of evidence in trial designs is proposed for trial outcomes: the "pyramid of endpoints." This pyramid represents a spectrum of outcomes from tangible health events to intermediate markers with no direct physical impact on an individual. The potential advantages and difficulties inherent in the use of surrogate endpoints for final health outcomes are explored. Randomized controlled trials utilizing "hard" clinical endpoints are advocated as the most efficient and reliable way to directly assess the benefits and harms of a therapy; however, using a case study of treatments for hepatocellular carcinoma, we highlight the challenges that can complicate even the highest levels of evidence. All trials have a "signal-to-noise" ratio - this review emphasizes the need for careful and deliberate consideration of the potential limitations of every study, and provides basic tools to assist the practitioner in identifying common pitfalls of clinical trials. Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.
C1 [Croswell, Jennifer M.; Kramer, Barnett S.] NIH, Off Dis Prevent, Bethesda, MD 20892 USA.
RP Croswell, JM (reprint author), NIH, Off Dis Prevent, 6100 Execut Blvd,Suite 2B-03, Bethesda, MD 20892 USA.
EM croswellj@od.nih.gov
NR 21
TC 10
Z9 10
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD APR
PY 2009
VL 50
IS 4
BP 817
EP 826
DI 10.1016/j.jhep.2009.01.005
PG 10
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 437UO
UT WOS:000265512600026
PM 19231015
ER
PT J
AU Wolf, SA
Steiner, B
Akpinarli, A
Kammertoens, T
Nassenstein, C
Braun, A
Blankenstein, T
Kempermann, G
AF Wolf, Susanne A.
Steiner, Barbara
Akpinarli, Akgul
Kammertoens, Thomas
Nassenstein, Christina
Braun, Armin
Blankenstein, Thomas
Kempermann, Gerd
TI CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the
Control of Adult Hippocampal Neurogenesis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID FACIAL MOTONEURON SURVIVAL; PHYSICAL-ACTIVITY; DENTATE GYRUS;
ALZHEIMERS-DISEASE; NERVE TRANSECTION; WATER MAZE; CELLS; IMMUNE; MICE;
BRAIN
AB Adult hippocampal neurogenesis occurs in an exceptional permissive microenvironment. Neuroimmunological mechanisms might be prominently involved in the endogenous homeostatic principles that control baseline levels of adult neurogenesis. We show in this study that this homeostasis is partially dependent on CD4-positive T lymphocytes. Systemic depletion of CD4-positive T lymphocytes led to significantly reduced hippocampal neurogenesis, impaired reversal learning in the Morris water maze, and decreased brain-derived neurotrophic factor expression in the brain. No such effect of CD8 or B cells was observed. Repopulation of RAG2(-/-) mice with CD4, but not with CD8 cells again increased precursor cell proliferation. The T cells in our experiments were non-CNS specific and rarely detectable in the healthy brain. Thus, we can exclude cell-cell contacts between immune and brain cells or lymphocyte infiltration into the CNS as a prerequisite for an effect. of CD4-T cells on neurogenesis. We propose that systemic CD4-T cell activity is required for maintaining cellular plasticity in the adult hippocampus and represents an evolutionary relevant communication route for the brain to respond to environmental changes. The Journal of Immunology, 2009, 182: 3979-3984.
C1 [Kempermann, Gerd] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, D-01307 Dresden, Germany.
[Wolf, Susanne A.; Steiner, Barbara; Kempermann, Gerd] Max Delbruck Ctr Mol Med, Res Grp Neuronal Stem Cell Res, Berlin, Germany.
[Wolf, Susanne A.; Steiner, Barbara; Kempermann, Gerd] Charite Univ Med Berlin, Volkswagenstiftung Res Grp, Dept Expt Neurol, D-13353 Berlin, Germany.
[Wolf, Susanne A.] Univ Zurich, Inst Anat, Dept Cell & Neurobiol, Zurich, Switzerland.
[Steiner, Barbara] Charite Univ Med Berlin, Dept Neurol, Campus Virchow Klinikum, D-13353 Berlin, Germany.
[Akpinarli, Akgul] NIAID, NIH, Cellular & Mol Immunol Lab, Bethesda, MD 20892 USA.
[Kammertoens, Thomas; Blankenstein, Thomas] Max Delbruck Ctr Mol Med, Res Grp Mol Immunol & Genetherapy, Berlin, Germany.
[Kammertoens, Thomas; Blankenstein, Thomas] Charite Inst Immunol, Berlin, Germany.
[Nassenstein, Christina; Braun, Armin] Fraunhofer Inst Toxicol & Expt Med Immunol & Alle, Hannover, Germany.
RP Kempermann, G (reprint author), Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Tatzberg 47-49, D-01307 Dresden, Germany.
EM gerd.kempermann@crt-dresden.de
RI Braun, Armin /B-8750-2009; Kempermann, Gerd/F-5416-2010; Wolf,
Susanne/A-1907-2011
OI Braun, Armin /0000-0002-1142-1463; Kempermann, Gerd/0000-0002-5304-4061;
FU Volkswagenstiftung; University Medicine Berlin
FX This work was supported by Volkswagenstiftung. B.S. is a Rabel Hirsch
fellow of Charite, University Medicine Berlin.
NR 47
TC 108
Z9 110
U1 2
U2 6
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
IS 7
BP 3979
EP 3984
DI 10.4049/jimmunol.0801218
PG 6
WC Immunology
SC Immunology
GA 424NY
UT WOS:000264574600010
PM 19299695
ER
PT J
AU Lee, J
Kuchen, S
Fischer, R
Chang, S
Lipsky, PE
AF Lee, Jisoo
Kuchen, Stefan
Fischer, Randy
Chang, Sooghee
Lipsky, Peter E.
TI Identification and Characterization of a Human CD5(+) Pre-Naive B Cell
Population
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; LYMPHOCYTE SUBSETS; RHEUMATOID-FACTOR;
PLASMA-CELLS; ANTIBODY; SELECTION; BLOOD; SIGNALS; RECONSTITUTION;
COMPARTMENT
AB We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB1 transporter compared with transitional and naive B cells. These pre-naive B cells account for a majority of circulating human CD5(+) B cells. Importantly, CD5(+) pre-naive B cells could be induced to differentiate into cells with a naive phenotype in vitro. CD5(+) pre-naive B cells show only partial responses to BCR stimulation and CD40 ligation and undergo more spontaneous apoptosis and cell death than do naive B cells, whereas BAFF/BLyS (B cell-activating factor belonging to the TNF family) did not enhance their survival compared with naive B cells. In contrast, CD5+ pre-naive B cells carry out certain functions comparable to naive B cells, including the capacity to differentiate into plasma cells and the ability to function as APCs. Notably, an increased proportion of CD5+ pre-naive B cells were found in peripheral blood of patients with systemic lupus erythematosus. These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus. The Journal of Immunology, 2009, 182: 4116-4126.
C1 [Lee, Jisoo; Kuchen, Stefan; Fischer, Randy; Lipsky, Peter E.] NIAMSD, Autoimmun Branch, NIH, Bethesda, MD 20892 USA.
[Lee, Jisoo] Ewha Womans Univ, Sch Med, Div Rheumatol, Dept Internal Med, Seoul, South Korea.
[Chang, Sooghee] Catholic Univ, Coll Med, Rheumatism Res Ctr, Seoul, South Korea.
RP Lipsky, PE (reprint author), NIAMSD, Autoimmun Branch, NIH, Bldg 10,Room 6D47C, Bethesda, MD 20892 USA.
EM peterlipsky@comcast.net
OI Kuchen, Stefan/0000-0003-4899-8132
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases;
National Institutes of Health; Korea Research Foundation
[KRF-2005-331-E00123]; Jean et Linette Warnery Foundation; Swiss
Foundation for Medical-Biological Scholarships
FX This research was supported in part by the National Institute of
Arthritis and Musculoskeletal and Skin Diseases, National Institutes of
Health. J.L. was supported by the Korea Research Foundation Grant
KRF-2005-331-E00123. S.K. was supported by the Jean et Linette Warnery
Foundation and the Swiss Foundation for Medical-Biological Scholarships.
NR 44
TC 66
Z9 67
U1 0
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
IS 7
BP 4116
EP 4126
DI 10.4049/jimmunol.0803391
PG 11
WC Immunology
SC Immunology
GA 424NY
UT WOS:000264574600024
PM 19299709
ER
PT J
AU Boasso, A
Vaccari, M
Fuchs, D
Hardy, AW
Tsai, WP
Tryniszewska, E
Shearer, GM
Franchini, G
AF Boasso, Adriano
Vaccari, Monica
Fuchs, Dietmar
Hardy, Andrew W.
Tsai, Wen-Po
Tryniszewska, Elzbieta
Shearer, Gene M.
Franchini, Genoveffa
TI Combined Effect of Antiretroviral Therapy and Blockade of IDO in
SIV-Infected Rhesus Macaques
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID REGULATORY T-CELLS; IMMUNODEFICIENCY-VIRUS-INFECTION; PRIMARY HUMAN
MACROPHAGES; INDOLEAMINE 2,3-DIOXYGENASE; HIV-1 INFECTION; TRYPTOPHAN
CATABOLISM; TOXOPLASMA-GONDII; IMMUNE ACTIVATION; GAMMA-INTERFERON;
DENDRITIC CELLS
AB Increased activity of IDO, which catalyzes the degradation of Trp into kynurenine (Kyn), is observed during HIV/SIV infection, and it may contribute to the persistence of HIV/SIV by suppressing antiviral T cell responses. We administered the IDO inhibitor 1-methyl-D-trypitophan (D-1mT) for 13 days to SIV-infected rhesus macaques receiving antiretroviral therapy (ART). D-1mT treatment increased the plasma levels of Trp, without reducing the levels of Kyn, suggesting only a partial effect on IDO enzymatic activity. Surprisingly, D-1mT significantly reduced the virus levels in plasma and lymph nodes of ART-treated animals with incomplete responsiveness to ART. In SIV-infected animals that were not receiving ART, D-1mT was ineffective in reducing the plasma viral load and had only a marginal effect on the plasma Kyn/Trp ratio. Increased IDO and TGF-beta mRNA expression in lymph nodes of ART-treated macaques after D-1mT treatment suggested that compensatory counterregulatory mechanisms were activated by D-1mT, which may account for the lack of effect on plasma Kyn. Finally, D-1mT did not interfere with the ART-induced T cell dynamics in lymph nodes (increased frequency of total CD4 T cells, increase of CD8 T cells expressing the antiapoptotic molecule Bcl2, and reduction of regulatory T cells). Thus, D-1mT appeared to synergize with ART in inhibiting viral replication and did not interfere with the beneficial immunologic effects of ART. Further studies are required to elucidate the immunologic or virologic mechanism by which D-1mT inhibited SIV replication in vivo. The Journal of Immunology, 2009, 182: 4313-4320.
C1 [Boasso, Adriano; Hardy, Andrew W.; Shearer, Gene M.] NCI, Expt Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Boasso, Adriano] Chelsea & Westminster Hosp, Imperial Coll, Fac Med, Dept Immunol, London SW10 9NH, England.
[Vaccari, Monica; Tsai, Wen-Po; Tryniszewska, Elzbieta; Franchini, Genoveffa] NCI, Anim Models & Retroviral Vaccines Sect, NIH, Bethesda, MD 20892 USA.
[Fuchs, Dietmar] Innsbruck Med Univ, Div Biol Chem, Bioctr, Innsbruck, Austria.
RP Boasso, A (reprint author), Chelsea & Westminster Hosp, Imperial Coll, Fac Med, Dept Immunol, 369 Fulham Rd, London SW10 9NH, England.
EM a.boasso@imperial.ac.uk
OI Boasso, Adriano/0000-0001-9673-6319
FU Intramural NIH HHS
NR 43
TC 49
Z9 49
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
IS 7
BP 4313
EP 4320
DI 10.4049/jimmunol.0803314
PG 8
WC Immunology
SC Immunology
GA 424NY
UT WOS:000264574600046
PM 19299731
ER
PT J
AU Salcedo, R
Hixon, JA
Stauffer, JK
Jalah, R
Brooks, AD
Khan, T
Dai, RM
Scheetz, L
Lincoln, E
Back, TC
Powell, D
Hurwitz, AA
Sayers, TJ
Kastelein, R
Pavlakis, GN
Felber, BK
Trinchieri, G
Wigginton, JM
AF Salcedo, Rosalba
Hixon, Julie A.
Stauffer, Jimmy K.
Jalah, Rashmi
Brooks, Alan D.
Khan, Tahira
Dai, Ren-Ming
Scheetz, Loretta
Lincoln, Erin
Back, Timothy C.
Powell, Douglas
Hurwitz, Arthur A.
Sayers, Thomas J.
Kastelein, Robert
Pavlakis, George N.
Felber, Barbara K.
Trinchieri, Giorgio
Wigginton, Jon M.
TI Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T
Cell Sensitization, Tumor-Specific CTL Reactivity and Complete
Regression of Disseminated Neuroblastoma Metastases in the Liver and
Bone Marrow
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID ESTABLISHED MURINE NEUROBLASTOMA; CHILDRENS CANCER GROUP;
COLON-CARCINOMA CELLS; DOSE INTERLEUKIN-2; ANTITUMOR-ACTIVITY; DENDRITIC
CELLS; IFN-GAMMA; IN-VIVO; REFRACTORY NEUROBLASTOMA; ANTIMETASTATIC
ACTIVITY
AB IL-27 exerts antitumor activity in murine orthotopic neuroblastoma, but only partial antitumor effect in disseminated disease. This study demonstrates that combined treatment with IL-2 and IL-27 induces potent antitumor activity in disseminated neuroblastoma metastasis. Complete durable tumor regression was achieved in 90% of mice bearing metastatic TBJ-IL-27 tumors treated with IL-2 compared with only 40% of mice bearing TBJ-IL-27 tumors alone and 0% of mice bearing TBJ-FLAG tumors with or without IL-2 treatment. Comparable antitumor effects were achieved by IL-27 protein produced upon hydrodynamic IL-27 plasmid DNA delivery when combined with IL-2. Although delivery of IL-27 alone, or in combination with M-2, mediated pronounced regression of neuroblastoma metastases in the liver, combined delivery of IL-27 and IL-2 was far more effective than IL-27 alone against bone marrow metastases. Combined exposure to IL-27 produced by tumor and IL-2 synergistically enhances the generation of tumor-specific CTL reactivity. Potentiation of CTL reactivity by IL-27 occurs via mechanisms that appear to be engaged during both the initial sensitization and effector phase. Potent immunologic memory responses are generated in mice cured of their disseminated disease by combined delivery of IL-27 and IL-2, and depletion of CD8(+) ablates the antitumor efficacy of this combination. Moreover, IL-27 delivery can inhibit the expansion of CD4(+)CD25(+)Foxp3(+) regulatory and IL-17-expressing CD4(+) cells that are otherwise observed among tumor-infiltrating lymphocytes from mice treated with IL-2. These studies demonstrate that IL-27 and IL-2 synergistically induce complete tumor regression and long-term survival in mice bearing widely metastatic neuroblastoma tumors. The Journal of Immunology, 2009, 182: 4328-4338.
C1 [Salcedo, Rosalba] NCI, Canc & Inflammat Program, Ctr Canc Res, Basic Res Program,Sci Applicat Int Corp Frederick, Frederick, MD 21702 USA.
[Stauffer, Jimmy K.; Scheetz, Loretta; Back, Timothy C.; Trinchieri, Giorgio] NCI, Expt Immunol Lab, Frederick, MD 21702 USA.
[Hixon, Julie A.; Hurwitz, Arthur A.] NCI, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
[Pavlakis, George N.] NCI, Human Retrovirus Sect, Frederick, MD 21702 USA.
[Jalah, Rashmi; Felber, Barbara K.] NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Frederick, MD 21702 USA.
[Powell, Douglas] NCI, Data Management Serv, Frederick, MD 21702 USA.
[Lincoln, Erin; Wigginton, Jon M.] NCI, Pediat Oncol Branch, Frederick, MD 21702 USA.
[Kastelein, Robert] Schering Plough Biopharma, Dept Discovery Biol, Palo Alto, CA 94304 USA.
RP Salcedo, R (reprint author), NCI, Canc & Inflammat Program, Ctr Canc Res, Basic Res Program,Sci Applicat Int Corp Frederick, Frederick Bldg 567,Room 207, Frederick, MD 21702 USA.
EM lmirosi@ncifcrf.gov
RI Sayers, Thomas/G-4859-2015
FU Intramural NIH HHS; NCI NIH HHS [N01 CO012400, N01-CO-12400, N01CO12400]
NR 62
TC 48
Z9 57
U1 2
U2 4
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
IS 7
BP 4328
EP 4338
DI 10.4049/jimmunol.0800471
PG 11
WC Immunology
SC Immunology
GA 424NY
UT WOS:000264574600048
PM 19299733
ER
PT J
AU Agyemang, A
Zhang, XY
Laky, K
Fowlkes, BJ
AF Agyemang, Amanda
Zhang, Xianyu
Laky, Karen
Fowlkes, B. J.
TI Coordinate Regulation of TCR signaling, Notch, and Gata3 in T Cell
Development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Agyemang, Amanda; Zhang, Xianyu; Laky, Karen; Fowlkes, B. J.] NIAID, LCMI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763603047
ER
PT J
AU Alimonti, JB
Qiu, XG
Fernando, L
Melito, L
Feldmann, F
Stroher, U
Feldmann, H
Jones, S
AF Alimonti, Judie B.
Qiu, Xiangguo
Fernando, Lisa
Melito, Leno
Feldmann, Friedericke
Stroher, Ute
Feldmann, Heinz
Jones, Steven
TI The VSV Delta G/ZEBOV GP vaccine protects against an Ebola infection and
induces humoral and cellular immunity
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Alimonti, Judie B.] Publ Hlth Agcy Canada, Winnipeg, MB, Canada.
[Alimonti, Judie B.; Stroher, Ute] Univ Manitoba, Med Microbiol, Winnipeg, MB, Canada.
[Qiu, Xiangguo; Fernando, Lisa; Melito, Leno; Stroher, Ute; Jones, Steven] Publ Hlth Agcy Canada, Special Pathogens, Winnipeg, MB, Canada.
[Feldmann, Friedericke; Feldmann, Heinz] NIH, Virol Lab, Hamilton, MT USA.
[Feldmann, Friedericke; Feldmann, Heinz] Publ Hlth Agcy Canada, Winnipeg, MB, Canada.
[Jones, Steven] Univ Manitoba, Immunol, Winnipeg, MB, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 128.16
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602124
ER
PT J
AU Allam, A
Torchia, MLG
Conze, D
Yagita, H
Munitic, I
Sowell, RT
Marzo, AL
Ashwell, JD
AF Allam, Atef
Torchia, Maria Letizia Giardino
Conze, Dietrich
Yagita, Hideo
Munitic, Ivana
Sowell, Ryan T.
Marzo, Amanda L.
Ashwell, Jonathan D.
TI The CD8+T cell memory state of readiness is actively maintained and
reversible
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Allam, Atef; Torchia, Maria Letizia Giardino; Conze, Dietrich; Ashwell, Jonathan D.] NCI, NIH, Bethesda, MD 20892 USA.
[Yagita, Hideo] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo, Japan.
[Munitic, Ivana] Necker Inst, Med Fac Rene Descartes, Paris, France.
[Sowell, Ryan T.; Marzo, Amanda L.] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 83.18
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601201
ER
PT J
AU Barber, DL
Mayer, KD
Antonelli, LR
Sher, A
AF Barber, Daniel L.
Mayer, Katrin D.
Antonelli, Lis R.
Sher, Alan
TI Adoptive transfer of CD4 T cells into T cell deficient Mycobacterium
avium infected mice results in a fatal Th1 disease that mimics human
Immune Reconstitution Inflammatory Syndrome (IRIS)
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Barber, Daniel L.; Mayer, Katrin D.; Antonelli, Lis R.; Sher, Alan] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 43.6
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600345
ER
PT J
AU Bergamaschi, C
Jalah, R
Kulkarni, V
Rosati, M
Valentin, A
Zhang, GM
Alicea, C
Zolotukhin, AS
Felber, BK
Pavlakis, GN
AF Bergamaschi, Cristina
Jalah, Rashmi
Kulkarni, Viraj
Rosati, Margherita
Valentin, Antonio
Zhang, Gen-mu
Alicea, Candido
Zolotukhin, Andrei S.
Felber, Barbara K.
Pavlakis, George N.
TI IL-15 Receptor alpha increases the stability and promotes secretion and
bioactivity of the short signal peptide variant of IL-15
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Bergamaschi, Cristina; Jalah, Rashmi; Kulkarni, Viraj; Rosati, Margherita; Valentin, Antonio; Zhang, Gen-mu; Alicea, Candido; Zolotukhin, Andrei S.; Felber, Barbara K.; Pavlakis, George N.] NCI, Ctr Canc Res, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 38.3
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600147
ER
PT J
AU Berger, AC
Roche, PA
AF Berger, Adam C.
Roche, Paul A.
TI The lipid environment regulates DM-dependent loading of foreign antigens
onto MHC class II in dendritic cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Berger, Adam C.; Roche, Paul A.] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 78.17
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601080
ER
PT J
AU Bergthaler, A
Flatz, L
Steinborn, R
Lutz, H
Suter, M
Pinschewer, DD
AF Bergthaler, Andreas
Flatz, Lukas
Steinborn, Ralf
Lutz, Hans
Suter, Mark
Pinschewer, Daniel D.
TI Attenuation of lymphocytic choriomeningitis virus relaxes
interferon-dependence of adaptive immune responses and of virus control
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Bergthaler, Andreas] Inst Syst Biol, Seattle, WA USA.
[Bergthaler, Andreas; Flatz, Lukas; Pinschewer, Daniel D.] Univ Geneva, Dept Pathol & Immunol, Geneva, Switzerland.
[Flatz, Lukas] NIH, Vaccine Res Ctr, Bethesda, MA USA.
[Steinborn, Ralf] Univ Vet Med, Inst Anim Breedings & Genet, Vienna, Austria.
[Lutz, Hans] Univ Zurich, Vetsuisse Fac, Clin Lab, Zurich, Switzerland.
[Suter, Mark] Univ Zurich, Inst Virol, Zurich, Switzerland.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 44.12
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600374
ER
PT J
AU Bhatia, S
Almo, SC
Nathenson, SG
Hodes, RJ
AF Bhatia, Sumeena
Almo, Steven C.
Nathenson, Stanley G.
Hodes, Richard J.
TI Dynamic equilibrium of B7-1 dimers and monomers is important for
regulation of TCR/CD28-mediated T cell activation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Bhatia, Sumeena; Hodes, Richard J.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
[Almo, Steven C.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
[Almo, Steven C.] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10467 USA.
[Nathenson, Stanley G.] Albert Einstein Coll Med, Dept Microiol & Immunol, Bronx, NY 10467 USA.
[Nathenson, Stanley G.] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 33.28
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600010
ER
PT J
AU Bubier, JA
Sproule, TJ
Foreman, O
Spolski, R
Morse, HC
Leonard, WJ
Roopenian, DC
AF Bubier, Jason A.
Sproule, Thomas J.
Foreman, Oded
Spolski, Rosanne
Morse, Herbert C.
Leonard, Warren J.
Roopenian, Derry C.
TI IL-21 Receptor signaling by B-cells is essential for BXSB-Yaa
pathogenesis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Bubier, Jason A.; Sproule, Thomas J.; Foreman, Oded; Roopenian, Derry C.] Jackson Lab, Bar Harbor, ME 04609 USA.
[Spolski, Rosanne; Leonard, Warren J.] NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA.
[Morse, Herbert C.] NIAID, Lab Immunopathol, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602092
ER
PT J
AU Butchi, NB
Du, M
Karin, P
AF Butchi, Niranjan B.
Du, Min
Karin, Peterson
TI Different innate immune profiles by astrocytes and microglia following
TLR7 and/or TLR9 agonist stimulation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Butchi, Niranjan B.; Du, Min; Karin, Peterson] NIAID, Lab Persistant Viral Dis, Hamilton, MT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.12
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602431
ER
PT J
AU Caspi, RR
Zhou, R
AF Caspi, Rachel R.
Zhou, Ru
TI Dual function for a vision-related molecule: retinoic acid in the eye
may contribute to ocular immune privilege
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Caspi, Rachel R.; Zhou, Ru] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 39.18
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600161
ER
PT J
AU Caucheteux, SM
Paul, WE
AF Caucheteux, Stephane M.
Paul, William E.
TI Do the lungs deliver naive CD4 T cells to draining nodes?
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Caucheteux, Stephane M.; Paul, William E.] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 95.13
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601477
ER
PT J
AU Chang, CH
Sofi, H
King, P
Schwartzberg, P
Qiao, Y
AF Chang, Cheong-Hee
Sofi, Hanief
King, Phil
Schwartzberg, Pam
Qiao, Yu
TI Unique properties of CD4 T cells selected by MHC class II expressing
thymocytes
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Chang, Cheong-Hee; Sofi, Hanief; King, Phil; Qiao, Yu] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA.
[Schwartzberg, Pam] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 85.1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601238
ER
PT J
AU Chatterjee, S
Deterding, L
Tucker, J
Corbett, J
Mason, RP
AF Chatterjee, Saurabh
Deterding, Leesa
Tucker, Jeff
Corbett, Jean
Mason, Ronald P.
TI Oxidative stress-induced protein radical formation precedes follicular
dendritic cell apoptosis in murine sepsis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Chatterjee, Saurabh; Corbett, Jean; Mason, Ronald P.] NIEHS, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Deterding, Leesa] NIEHS, Lab Struct Biol, NIH, Res Triangle Pk, NC 27709 USA.
[Tucker, Jeff] NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 92.3
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601420
ER
PT J
AU Chen, KQ
Huang, J
Gong, WH
Dunlop, NM
Cui, YH
Wang, JM
AF Chen, Keqiang
Huang, Jian
Gong, Wanghua
Dunlop, Nancy M.
Cui, Youhong
Wang, Ji Ming
TI Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating
expression of mouse FPR2, a promiscuous G-protein coupled receptor, in
microglial cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Chen, Keqiang; Huang, Jian; Dunlop, Nancy M.; Wang, Ji Ming] NCI, Lab Mol Immunoregulat, Frederick, MD 21701 USA.
[Gong, Wanghua] SAIC Frederick, Lab Mol Immunoregulat, Frederick, MD USA.
[Cui, Youhong] Shantou Univ, Inst Inflammat & Immunol Dis, Coll Med, Shantou, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 92.9
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601413
ER
PT J
AU Choi, SC
Narayanan, S
Borrego, F
Coligan, JE
AF Choi, Seung-Chul
Narayanan, Sriram
Borrego, Francisco
Coligan, John E.
TI Toso expression during B cell development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Choi, Seung-Chul; Narayanan, Sriram; Coligan, John E.] NIAID, RCBS, LIG, NIH, Rockville, MD USA.
[Borrego, Francisco] US FDA, LMDB, CDER, Bethesda, MD 20014 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 82.3
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601188
ER
PT J
AU Chung, Y
Chang, SH
Martinez, GJ
Yang, XXO
Nurieva, R
Kang, HS
Watowich, SS
Jetten, A
Dong, C
AF Chung, Yeonseok
Chang, Seon Hee
Martinez, Gustavo J.
Yang, Xuexian O.
Nurieva, Roza
Kang, Hong Soon
Watowich, Stephanie S.
Jetten, Anton
Dong, Chen
TI Critical regulation of early Th17 cell differentiation by IL-1 signaling
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Chung, Yeonseok; Chang, Seon Hee; Martinez, Gustavo J.; Yang, Xuexian O.; Nurieva, Roza; Watowich, Stephanie S.; Dong, Chen] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Kang, Hong Soon; Jetten, Anton] Natl Inst Environm Sci, NIH, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 48.24
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600476
ER
PT J
AU Cousens, LP
Terry, FE
Falanga, V
AF Cousens, Leslie P.
Terry, Frances E.
Falanga, Vincent
TI New Applications for Bispecific Antibodies in Wound Healing
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Cousens, Leslie P.; Terry, Frances E.; Falanga, Vincent] Roger Williams Med Ctr, Ctr Biomed Res Excellence, Providence, RI USA.
[Falanga, Vincent] Roger Williams Med Ctr, Dept Dermatol, Providence, RI USA.
[Falanga, Vincent] Boston Univ, Providence, RI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 94.16
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601467
ER
PT J
AU Cruz, AC
Ramaswamy, M
Siegel, RM
AF Cruz, Anthony C.
Ramaswamy, Madhu
Siegel, Richard M.
TI Human CD4+memory T cells are pre-sensitized to Fas-mediated apoptosis
due to increased receptor localization to lipid raft microdomains
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Cruz, Anthony C.; Ramaswamy, Madhu; Siegel, Richard M.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 35.38
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600076
ER
PT J
AU Du, M
Butchi, N
Peterson, KE
AF Du, Min
Butchi, Niranjian
Peterson, Karin E.
TI Poly-T oligonucleotides enhance TLR7/8 agonist induced responses in
glial cells through a TLR7-dependent mechanism
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Du, Min; Butchi, Niranjian; Peterson, Karin E.] NIAID, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.11
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602413
ER
PT J
AU Gibbs, JD
Ornoff, DM
Igo, HA
Imani, F
AF Gibbs, John D.
Ornoff, Douglas M.
Igo, Heather A.
Imani, Farhad
TI RSV Infection Promotes Cell Cycle Arrest Through TGF-beta Autocrine
Regulation; A Critical Stage for Enhanced RSV Replication in Lung
Epithelial Cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Gibbs, John D.; Ornoff, Douglas M.; Igo, Heather A.; Imani, Farhad] NIEHS, Lab Resp Biol, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 79.21
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601137
ER
PT J
AU Gross, CC
Martinez, E
Long, EO
AF Gross, Catharina C.
Martinez, Emily
Long, Eric O.
TI Control of NK cell activation by distribution and mobility of ligands on
target cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Gross, Catharina C.; Martinez, Emily; Long, Eric O.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 134.16
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602299
ER
PT J
AU Guiraldelli, MF
Berenstein, EH
Siraganian, RP
AF Guiraldelli, Michel F.
Berenstein, Elsa H.
Siraganian, Reuben P.
TI A Monoclonal Antibody that inhibits IgE binding to the High affinity IgE
receptor recognizes a glycolipid
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Guiraldelli, Michel F.; Berenstein, Elsa H.; Siraganian, Reuben P.] NIDCR, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 36.11
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600100
ER
PT J
AU Heller, NM
Qi, XL
Junttila, IS
Shirey, KA
Vogel, SN
Paul, WE
Keegan, AD
AF Heller, Nicola M.
Qi, Xiulan
Junttila, Ilkka S.
Shirey, Kari Ann
Vogel, Stefanie N.
Paul, William E.
Keegan, Achsah D.
TI IRS-2 phosphorylation and association with p85 and Grb2 after engagement
of type I IL-4 receptor
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Heller, Nicola M.; Qi, Xiulan; Keegan, Achsah D.] Univ Maryland, SOM, Ctr Vasc & Inflammatory Dis, Baltimore, MD 21201 USA.
[Heller, Nicola M.; Qi, Xiulan; Keegan, Achsah D.] Univ Maryland, SOM, Greenebaum Canc Ctr, Baltimore, MD 21201 USA.
[Heller, Nicola M.; Shirey, Kari Ann; Vogel, Stefanie N.] Univ Maryland, SOM, Microbiol & Immunol, Baltimore, MD 21201 USA.
[Junttila, Ilkka S.; Paul, William E.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 38.2
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600131
ER
PT J
AU Nguyen, H
Weng, NP
AF Huy Nguyen
Weng, Nan-ping
TI IL-15 and IL-21 Mediated Homeostatic Proliferation of Human CD8 Memory T
cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Huy Nguyen; Weng, Nan-ping] NIA, Immunol Lab, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 96.7
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601496
ER
PT J
AU Imani, F
Prater, C
Thakur, S
AF Imani, Farhad
Prater, Chrissy
Thakur, Sheetal
TI Inosine-Containing ssRNA Is a Novel Viral-Associated Immune Recognition
Element
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Imani, Farhad; Prater, Chrissy; Thakur, Sheetal] NIEHS, NIH, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 43.3
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600343
ER
PT J
AU Jacobelli, J
Friedman, RS
Conti, MA
Khan, O
Sorensen, C
Adelstein, RS
Krummel, MF
AF Jacobelli, Jordan
Friedman, Rachel S.
Conti, Mary Anne
Khan, Omar
Sorensen, Caitlin
Adelstein, Robert S.
Krummel, Matthew F.
TI T cell trans-endothelial migration and homing to lymph nodes rely on
Myosin-IIA mediated acto-myosin contractility
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Jacobelli, Jordan; Friedman, Rachel S.; Khan, Omar; Sorensen, Caitlin; Krummel, Matthew F.] Univ Calif San Francisco, Pathol, San Francisco, CA 94143 USA.
[Conti, Mary Anne; Adelstein, Robert S.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 94.25
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601475
ER
PT J
AU Jankovic, D
Andersen, J
Steinfelder, S
Cannons, JL
Schwartzberg, PL
Sher, A
AF Jankovic, Dragana
Andersen, John
Steinfelder, Svenja
Cannons, Jennifer L.
Schwartzberg, Pamela L.
Sher, Alan
TI The major Th2 polarizing component in schistosome eggs is a T2
ribonuclease (omega-1) that inhibits dendritic-T cell interaction
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Jankovic, Dragana; Steinfelder, Svenja; Sher, Alan] NIAID, LPD, Bethesda, MD 20892 USA.
[Andersen, John] NIAID, LMVR, Rockville, MD USA.
[Cannons, Jennifer L.; Schwartzberg, Pamela L.] NHGRI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 133.23
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602246
ER
PT J
AU Jenkinson, SR
Zuklys, S
Hollander, GA
Koni, PA
Reizis, B
Hodes, RJ
AF Jenkinson, S. Rhiannon
Zuklys, Saulius
Hollander, Georg A.
Koni, Pandelakis A.
Reizis, Boris
Hodes, Richard J.
TI Importance of MHCII expression on thymic epithelium versus dendritic
cells for the positive and negative selection of CD4 T Cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Jenkinson, S. Rhiannon; Hodes, Richard J.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
[Zuklys, Saulius; Hollander, Georg A.] Univ Childrens Hosp Basel, Basel, Switzerland.
[Koni, Pandelakis A.] Med Coll Georgia, Augusta, GA 30912 USA.
[Reizis, Boris] Columbia Univ, Med Ctr, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763603041
ER
PT J
AU Jin, TC
Jiang, JS
Perry, A
Xiao, T
AF Jin, Tengchuan
Jiang, Jiansheng
Perry, Andrew
Xiao, Tsan
TI Structure of NALPI/NLRPI leucine-rich repeats and potential ligand
binding
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Jin, Tengchuan; Jiang, Jiansheng; Perry, Andrew; Xiao, Tsan] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.79
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602411
ER
PT J
AU Kawabe, M
Mandic, M
Taylor, J
Vasquez, C
Wesa, A
Neckers, L
Storkus, W
AF Kawabe, Mayumi
Mandic, Maja
Taylor, Jennifer
Vasquez, Cecilia
Wesa, Amy
Neckers, Leonard
Storkus, Walter
TI HSP90 inhibitor 17-DMAG enhances EphA2+tumor cell recognition by
specific CD8+T cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Kawabe, Mayumi; Storkus, Walter] Univ Pittsburgh, Immunol, Pittsburgh, PA USA.
[Mandic, Maja; Taylor, Jennifer; Vasquez, Cecilia; Wesa, Amy; Storkus, Walter] Univ Pittsburgh, Dermatol, Pittsburgh, PA USA.
[Neckers, Leonard] NCI, Urol Oncol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 40.27
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600212
ER
PT J
AU Kibe, R
Zhang, SZ
Marrero, L
Khan, S
Zieske, A
Huang, JQ
Durum, SK
Iwakuma, T
Cui, Y
AF Kibe, Ryoko
Zhang, Shu-zhong
Marrero, Luis
Khan, Shafin
Zieske, Arthur
Huang, Jiaqiang
Durum, Scott K.
Iwakuma, Tomoo
Cui, Yan
TI Cross-talk between IL-7Ra signaling and p53 pathway during thymopoiesis
and lymphomagenesis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Kibe, Ryoko; Zhang, Shu-zhong; Marrero, Luis; Khan, Shafin] Louisiana State Univ, Hlth Sci Ctr, Med, New Orleans, LA USA.
[Zieske, Arthur] Louisiana State Univ, Hlth Sci Ctr, Pathol, New Orleans, LA USA.
[Huang, Jiaqiang; Durum, Scott K.] NCI, Sect Cytokines & Immun, Frederick, MD 21701 USA.
[Iwakuma, Tomoo] Louisiana State Univ, Hlth Sci Ctr, Genet, New Orleans, LA USA.
[Cui, Yan] Louisiana State Univ, Hlth Sci Ctr, Genet, Med, New Orleans, LA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 86.8
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601263
ER
PT J
AU Kim, YC
Kim, KK
Shevach, EM
AF Kim, Yong Chan
Kim, Kee Kwang
Shevach, Ethan M.
TI T cell receptor-mediated protein geranylgeranylation controls
transforming growth factor-beta-induced Foxp3 expression by regulating
the induction of Smad6/7
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Kim, Yong Chan; Shevach, Ethan M.] NIAID, Immunol Lab, Bethesda, MD 20892 USA.
[Kim, Kee Kwang] NHLBI, Mol Cardiol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 50.40
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601042
ER
PT J
AU Kole, HK
Deane, JA
BoHand, S
AF Kole, Hemanta K.
Deane, Jonathan A.
BoHand, Silvia
TI Infection with VSV ameliorates autoimmune disease in Fc gamma R2B
deficient mice
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Kole, Hemanta K.; Deane, Jonathan A.; BoHand, Silvia] NIAID, Autoimmun & Funct Genom Sect, Immunogenet Lab, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 50.23
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601039
ER
PT J
AU Lesourne, R
Love, P
AF Lesourne, Renaud
Love, Paul
TI AGAPE, a new T cell specific Grb2 binding protein that plays a critical
role in T cell development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Lesourne, Renaud; Love, Paul] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 85.7
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601243
ER
PT J
AU Lin, L
Ibrahim, AS
Avanesian, V
Xu, X
Farber, J
Fu, Y
Baquir, B
Spellberg, B
AF Lin, Lin
Ibrahim, Ashraf S.
Avanesian, Valentina
Xu, Xin
Farber, Joshua
Fu, Yue
Baquir, Beverly
Spellberg, Brad
TI Th17 Cells Are Not Required for Host Defense Against Murine Disseminated
Candidiasis, But Are Required for Vaccine-Mediated Protection
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Lin, Lin; Ibrahim, Ashraf S.; Avanesian, Valentina; Fu, Yue; Baquir, Beverly; Spellberg, Brad] Harbor UCLA Med Ctr, LosAngeles Biomed Res Inst, Div Infect Dis, Torrance, CA 90509 USA.
[Xu, Xin; Farber, Joshua] NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 132.10
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602210
ER
PT J
AU Liu, DF
Bryceson, YT
Meckel, T
Vasiliver, G
Dustin, ML
Long, EO
AF Liu, Dongfang
Bryceson, Yenan T.
Meckel, Tobias
Vasiliver, Gala
Dustin, Michael L.
Long, Eric O.
TI Live Imaging of Cytotoxic Immune Synapses Reveals LFA-1-dependent Ligand
Distribution and Bidirectional Vesicular Traffic
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Liu, Dongfang; Meckel, Tobias; Long, Eric O.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
[Bryceson, Yenan T.] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.
[Vasiliver, Gala; Dustin, Michael L.] NYU, Sch Med, Dept Pathol, Skirball Inst Biomol Med, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 134.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602284
ER
PT J
AU Liu, J
Ruckwardt, T
Chen, M
Johnson, T
Graham, B
AF Liu, Jie
Ruckwardt, Tracy
Chen, Man
Johnson, Teresa
Graham, Barney
TI Epitope-Specific Regulatory T cells Differentially Modulate the CD8 T
Cell Response to Respiratory Syncytial Virus in Mice
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Liu, Jie; Ruckwardt, Tracy; Chen, Man; Johnson, Teresa; Graham, Barney] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 45.29
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600408
ER
PT J
AU Lopez, GP
Ostap, EM
Shaw, S
AF Lopez, Genaro Patino
Ostap, E. Michael
Shaw, Stephen
TI Myosin 1G is a hematopoietic-restricted protein highly enriched in
lymphocyte plasma membrane/microvilli whose deficiency impairs
lymphocyte activation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Lopez, Genaro Patino; Shaw, Stephen] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
[Ostap, E. Michael] Univ Penn, Sch Med, Penn Muscle Inst, Philadelphia, PA 19104 USA.
[Ostap, E. Michael] Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 35.40
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600070
ER
PT J
AU Maravillas-Montero, JL
Gillespie, PG
Patino-Lopez, G
Shaw, S
Santos-Argumedo, L
AF Luis Maravillas-Montero, Jose
Gillespie, Peter G.
Patino-Lopez, Genaro
Shaw, Stephen
Santos-Argumedo, Leopoldo
TI Possible role of class I myosins in molecule segregation at B cell
microvilli structures
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Luis Maravillas-Montero, Jose; Santos-Argumedo, Leopoldo] Inst Politecn Nacl CINVESTAV IPN, Ctr Invest & Estudios Avanzado, Mol Biomed, Mexico City, DF, Mexico.
[Gillespie, Peter G.] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97201 USA.
[Gillespie, Peter G.] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA.
[Patino-Lopez, Genaro; Shaw, Stephen] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 78.37
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601107
ER
PT J
AU Lyakh, LA
Cardone, M
Riboldi, E
Trinchieri, G
AF Lyakh, Lyudmila A.
Cardone, Marco
Riboldi, Elena
Trinchieri, Giorgio
TI Regulation of IL-1 beta and IL-23 production by beta-glucan in human
dendritic cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Lyakh, Lyudmila A.; Cardone, Marco; Riboldi, Elena; Trinchieri, Giorgio] NCI, Canc & Inflammat Program, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.76
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602410
ER
PT J
AU Mage, M
Levin, D
Revilleza, MJ
Boyd, L
Natarajan, K
Shevach, E
Margulies, D
AF Mage, Michael
Levin, Ditza
Revilleza, Maria J.
Boyd, Lisa
Natarajan, Kannan
Shevach, Ethan
Margulies, David
TI Class II MHC-Binding Peptides are Active Over a Broad Range of
Affinities for MHC
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Mage, Michael; Revilleza, Maria J.; Boyd, Lisa; Natarajan, Kannan; Shevach, Ethan; Margulies, David] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
[Levin, Ditza] Ort Braude Coll, Biotechnol Engn, Karmiel, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 49.29
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601003
ER
PT J
AU Mage, RG
AF Mage, Rose G.
TI Genes encoding proteins of immunological interest in the Oryctolagus
cuniculus (rabbit) whole genome sequences and ENCODE
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Mage, Rose G.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 81.19
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601174
ER
PT J
AU Mayer, KD
Barber, DL
Sher, A
AF Mayer, Katrin D.
Barber, Daniel L.
Sher, Alan
TI In MyD88-/- mice infected with Mycobacterium tuberculosis ESAT6-specific
CD4 T cells expand normally but display impaired IFN-gamma production
due to a T cell intrinsic role for the adaptor molecule
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Mayer, Katrin D.; Barber, Daniel L.; Sher, Alan] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 129.19
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602166
ER
PT J
AU McCoy, JP
Tatlici, G
Samsel, L
Raghavachari, N
Liu, PC
Liu, DL
Munson, PJ
Gourley, M
AF McCoy, J. Philip, Jr.
Tatlici, Gulnaz
Samsel, Leigh
Raghavachari, Nalini
Liu, Poching
Liu, Delong
Munson, Peter J.
Gourley, Mark
TI CD146+T lymphocytes are increased in both the peripheral circulation and
in the synovial fluids of patients with various musculoskeletal diseases
and may facilitate T and B interactions
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [McCoy, J. Philip, Jr.; Tatlici, Gulnaz; Samsel, Leigh] NHLBI, Hematol Branch, DIR, Bethesda, MD 20892 USA.
[Raghavachari, Nalini; Liu, Poching] NHLBI, Pulm & Vasc Med Branch, DIR, NIH, Bethesda, MD 20892 USA.
[Liu, Delong; Munson, Peter J.] NIH, CIT, Bethesda, MD 20892 USA.
[Gourley, Mark] NIAMS, IRP, OCD, CCTB,NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 95.11
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601479
ER
PT J
AU McPhee, C
Bubier, J
Morse, H
Foreman, O
Roopenian, D
AF McPhee, Caroline
Bubier, Jason
Morse, Herbert
Foreman, Oded
Roopenian, Derry
TI Characterizing the pathophysiology of Systemic Lupus Erythematosis
disease progression in the BXSB Yaa CD8-/-,1L15-/- mouse model
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [McPhee, Caroline; Bubier, Jason; Foreman, Oded; Roopenian, Derry] Jackson Lab, Bar Harbor, ME 04609 USA.
[Morse, Herbert] NIAID, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 99.16
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602064
ER
PT J
AU Medvedev, AE
Chen, HY
Song, C
Wah, LM
Fitzgerald, KA
Li, LW
Piao, WJ
AF Medvedev, Andrei E.
Chen, Haiyan
Song, Chang
Wah, Larry M.
Fitzgerald, Katherine A.
Li, Liwu
Piao, Wenji
TI Reprogramming of TLR4 pathways in endotoxin-tolerant cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Medvedev, Andrei E.; Chen, Haiyan; Song, Chang; Piao, Wenji] Univ Maryland, Microbiol & Immunol, Baltimore, MD 21201 USA.
[Wah, Larry M.] NIDCR, NIH, Bethesda, MD USA.
[Fitzgerald, Katherine A.] Univ Massachusetts Med Sch, Worcester, MA USA.
[Li, Liwu] Virginia Tech, Blacksburg, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.25
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602368
ER
PT J
AU Meylan, F
Song, YJ
Maim, I
Acharya, K
Kahle, E
Fuss, I
Strober, W
Belkaid, Y
Siegel, R
AF Meylan, Francoise
Song, Yun-Jeong
Maim, Ian
Acharya, Krishika
Kahle, Erin
Fuss, Ivan
Strober, Warren
Belkaid, Yasmine
Siegel, Richard
TI The role of TL1A-DR3 TNF-family interactions in inflammatory bowel
disease
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Meylan, Francoise; Song, Yun-Jeong; Maim, Ian; Acharya, Krishika; Kahle, Erin; Siegel, Richard] NIAMS, Immunoregulat, NIH, Bethesda, MD USA.
[Fuss, Ivan; Strober, Warren] NIAID, LHD, NIH, Bethesda, MD 20892 USA.
[Belkaid, Yasmine] NIAID, Immunobiol Sect, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 39.3
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600151
ER
PT J
AU Narayanan, S
Borrego, F
Coligan, JE
AF Narayanan, Sriram
Borrego, Francisco
Coligan, John E.
TI Role of TOSO in activation induced cell death of human T- and NK cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Narayanan, Sriram; Coligan, John E.] NIAID, RCBS, LIG, NIH, Rockville, MD USA.
[Borrego, Francisco] US FDA, Bethesda, MD 20014 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 82.2
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601182
ER
PT J
AU Ng, SSM
Tailor, P
Chang, TH
Ozato, K
Kino, T
AF Ng, Sinnie Sin Man
Tailor, Prafullakumar
Chang, Tsung-Hsien
Ozato, Keiko
Kino, Tomoshige
TI Viral infection alters mRNA expression of nuclear hormone receptors
(NRs) and their coregulators in mouse dendritic cells (DCs)
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Ng, Sinnie Sin Man; Tailor, Prafullakumar; Chang, Tsung-Hsien; Ozato, Keiko; Kino, Tomoshige] NICHD, NIH, Bethesda, MD USA.
[Ng, Sinnie Sin Man] Chinese Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 131.1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602197
ER
PT J
AU Odumade, OA
Weinreich, MA
Takada, K
McCaughtry, T
Carlson, CM
Lingrel, J
Elewaut, D
Jameson, SC
Hogguist, KA
AF Odumade, Oludare A.
Weinreich, Michael A.
Takada, Kensuke
McCaughtry, Tom
Carlson, Corey M.
Lingrel, Jerry
Elewaut, Dirk
Jameson, Stephen C.
Hogguist, Kristin A.
TI The role of Kruppel-like factor 2 (KLF2) in thymic emigration and
trafficking of non-conventional T cell lineages
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Odumade, Oludare A.; Weinreich, Michael A.; Takada, Kensuke; Jameson, Stephen C.; Hogguist, Kristin A.] Univ Minnesota, Lab Med & Pathol, Minneapolis, MN USA.
[McCaughtry, Tom] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
[Carlson, Corey M.] Beckman Coulter, Chaska, MN USA.
[Lingrel, Jerry] Univ Cincinnati, Mol Genet, Cincinnati, OH USA.
[Elewaut, Dirk] Univ Ghent, Lab Mol Immunol & Inflammat, Ghent, Belgium.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 82.16
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601191
ER
PT J
AU Orr, SJ
Quigley, L
McVicar, DW
AF Orr, Selinda J.
Quigley, Laura
McVicar, Daniel W.
TI Over-expression of constitutively active PI3K p110 gamma alters NK cell
development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Orr, Selinda J.; Quigley, Laura; McVicar, Daniel W.] NCI, Expt Immunol Lab, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 134.4
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602346
ER
PT J
AU Pages, BB
Roche, PA
AF Pages, Berta Bosch
Roche, Paul A.
TI The membrane distribution of MHC-II-peptide complexes and its role in T
cell activation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Pages, Berta Bosch; Roche, Paul A.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 78.18
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601106
ER
PT J
AU Prots, I
Skapenko, A
Lipsky, PE
Schulze-Koops, H
AF Prots, Iryna
Skapenko, Alla
Lipsky, Peter E.
Schulze-Koops, Hendrik
TI The neuropeptide npT1 is specifically expressed in human CD25+regulatory
T cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Prots, Iryna; Skapenko, Alla; Schulze-Koops, Hendrik] Univ Munich, Div Rheumatol, Med Poliklin, Munich, Germany.
[Lipsky, Peter E.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 89.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601328
ER
PT J
AU Radinger, M
Kuehn, HS
Kim, MS
Metcalfe, DD
Gilfillan, AM
AF Radinger, Madeleine
Kuehn, Hye Sun
Kim, Mi-Sun
Metcalfe, Dean D.
Gilfillan, Alasdair M.
TI Glycogen Synthase Kinase-3p regulates antigen/SCF-mediated cytokine
production and SCF-mediated chemotaxis in human mast cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Radinger, Madeleine; Kuehn, Hye Sun; Kim, Mi-Sun; Metcalfe, Dean D.; Gilfillan, Alasdair M.] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 93.6
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601442
ER
PT J
AU Ramaswamy, M
Cruz, AC
Siegel, RM
AF Ramaswamy, Madhu
Cruz, Anthony C.
Siegel, Richard M.
TI Fas induced apoptosis and Restimulation Induced Cell Death (RICD) is
restricted to human effector memory CD4+T subsets
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Ramaswamy, Madhu; Cruz, Anthony C.; Siegel, Richard M.] NIAMS, Immunoregulat Unit, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 46.8
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600417
ER
PT J
AU Revilleza, MJR
Levin, D
Mage, MG
Teyton, L
Robinson, H
Shevach, EM
Natarajan, K
AF Revilleza, Maria Jamela Roxas
Levin, Ditza
Mage, Michael G.
Teyton, Luc
Robinson, Howard
Shevach, Ethan M.
Natarajan, Kannan
TI A self-peptide with large anchor residues binds IAd and induces Th2-like
autoimmune gastritis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Revilleza, Maria Jamela Roxas; Mage, Michael G.; Shevach, Ethan M.; Natarajan, Kannan] NIAID, Mol Biol Sect, LI, NIH, Bethesda, MD 20892 USA.
[Levin, Ditza] Oil Braude Engn Coll, Biotechnol Engn Dept, Karmiel, Israel.
[Teyton, Luc] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA.
[Robinson, Howard] Brookhaven Natl Lab, Upton, NY 11973 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602107
ER
PT J
AU Sato, T
Shimosato, T
Klinman, DM
AF Sato, Takashi
Shimosato, Takeshi
Klinman, Dennis M.
TI CpG oligodeoxynucleotide incorporated basement membrane extract
facilitate wound repair in mice
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Sato, Takashi] Yokohama City Univ, Internal Med & Clin Immunol, Yokohama, Kanagawa, Japan.
[Shimosato, Takeshi] Shinshu Univ, Fiber Nanotech Young Researcher Empowerment Ctr, Nagano, Japan.
[Klinman, Dennis M.] NCI, Ctr Canc Res, Expt Immunol Lab, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 135.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602390
ER
PT J
AU Savan, R
Yalamanchili, R
Hakim, S
Young, HA
AF Savan, Ram
Yalamanchili, Rajesh
Hakim, Shakeeb
Young, Howard A.
TI Role of micro-RNA and AU-rich elements in post-transcriptional
regulation of interferon gamma
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Savan, Ram; Yalamanchili, Rajesh; Hakim, Shakeeb; Young, Howard A.] NCI, Expt Immunol Lab, CIP, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 38.1
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600142
ER
PT J
AU Sawalha, A
Webb, R
Merrill, J
Kelly, J
Sestak, A
Kaufman, K
Langefeld, C
Ziegler, J
Kimberly, R
Edberg, J
Ramsey-Goldman, R
Petri, M
Reveille, J
Alarcon, G
Vila, L
Alarcon-Riquelme, M
James, J
Gilkeson, G
Jacob, C
Moser, K
Gaffney, P
Vyse, T
Nath, S
Lipsky, P
Harley, J
AF Sawalha, Amr
Webb, R.
Merrill, J.
Kelly, J.
Sestak, A.
Kaufman, K.
Langefeld, C.
Ziegler, J.
Kimberly, R.
Edberg, J.
Ramsey-Goldman, R.
Petri, M.
Reveille, J.
Alarcon, G.
Vila, L.
Alarcon-Riquelme, M.
James, J.
Gilkeson, G.
Jacob, C.
Moser, K.
Gaffney, P.
Vyse, T.
Nath, S.
Lipsky, P.
Harley, J.
TI A polymorphism within interleukin-21 receptor (IL21R) confers risk for
systemic lupus erythematosus and is associated with malar rash in lupus
patients
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Sawalha, Amr; Kaufman, K.; Harley, J.] OUHSC VA, Okc, OK USA.
[Sawalha, Amr; Webb, R.; Merrill, J.; Kelly, J.; Sestak, A.; Kaufman, K.; James, J.; Moser, K.; Gaffney, P.; Nath, S.; Harley, J.] OMRF, Okc, OK USA.
[Langefeld, C.; Ziegler, J.] WFUHS, Winston Salem, NC USA.
[Kimberly, R.; Edberg, J.; Alarcon, G.] UAB, Birmingham, AL USA.
[Ramsey-Goldman, R.] Northwestern Univ, Chicago, IL 60611 USA.
[Petri, M.] Johns Hopkins Univ, Baltimore, MD USA.
[Reveille, J.] UT Houston, Houston, TX USA.
[Vila, L.] Univ Puerto Rico, San Juan, PR 00936 USA.
[Alarcon-Riquelme, M.] Uppsala Univ, Uppsala, Sweden.
[Gilkeson, G.] MUSC, Charleston, SC USA.
[Jacob, C.] USC, Los Angeles, CA USA.
[Vyse, T.] Imperial Coll, London, England.
[Lipsky, P.] NIAMS, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 49.17
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601005
ER
PT J
AU Shi, GP
Ramaswamy, M
Vistica, BP
Tan, CY
Wawrousek, EF
Siegel, RM
Gery, I
AF Shi, Guangpu
Ramaswamy, Madhu
Vistica, Barbara P.
Tan, Cuiyan
Wawrousek, Eric F.
Siegel, Richard M.
Gery, Igal
TI Th17 cells mediate sustained autoimmune inflammation and are highly
resistant to restimulation-induced cell death
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Shi, Guangpu; Vistica, Barbara P.; Tan, Cuiyan; Gery, Igal] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
[Ramaswamy, Madhu; Siegel, Richard M.] NIAMS, Autoimmun Branch, NIH, Bethesda, MD USA.
[Wawrousek, Eric F.] NEI, Lab Mol & Dev Biol, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 137.17
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602494
ER
PT J
AU Silaghi, A
Fernando, L
Alimonti, J
Stroeher, U
Feldmann, H
Jones, SM
AF Silaghi, Alex
Fernando, Lisa
Alimonti, Judie
Stroeher, Ute
Feldmann, Heinz
Jones, Steven M.
TI VSV Delta G MARV GP and VSV Delta G ZEBOV GP induce strong and rapid
anti-viral state in mouse peritoneal macrophages through type I
interferon stimulation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Silaghi, Alex; Alimonti, Judie; Stroeher, Ute; Jones, Steven M.] Univ Manitoba, Med Microbiol, Winnipeg, MB, Canada.
[Silaghi, Alex; Fernando, Lisa; Alimonti, Judie; Stroeher, Ute; Jones, Steven M.] Publ Hlth Agcy Canada, Special Pathogens, Winnipeg, MB, Canada.
[Feldmann, Heinz] NIAID, Virol Lab, Hamilton, MT USA.
[Feldmann, Heinz] Univ Manitoba, Med Microbiol, Winnipeg, MB, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 128.11
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602142
ER
PT J
AU Smigiel, K
Darrah, P
Fogg, C
Harvey, R
Tullo, G
Seder, R
Burns, J
Long, C
AF Smigiel, Kate
Darrah, Patricia
Fogg, Chris
Harvey, Reid
Tullo, Greg
Seder, Robert
Burns, James
Long, Carole
TI The antigen-specific CD4 host response to Plasmodium yoelii 17XL
infection after protective MSP-8 immunization alters multifunctional
cytokine profiles
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Smigiel, Kate; Fogg, Chris; Harvey, Reid; Tullo, Greg; Long, Carole] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA.
[Darrah, Patricia; Seder, Robert] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Burns, James] Drexel Univ, Coll Med, Microbiol & Immunol, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 45.13
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600392
ER
PT J
AU Spolski, R
Leonard, WJ
AF Spolski, Rosanne
Leonard, Warren J.
TI Interleukin-21 mediates unanticipated suppressive effects via its
induction of IL-10
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Spolski, Rosanne; Leonard, Warren J.] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 97.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602020
ER
PT J
AU Stewart, CA
Scheetz, L
Trinchieri, G
AF Stewart, Charles A.
Scheetz, Loretta
Trinchieri, Giorgio
TI Tumor IL-10 forms an immediate non-redundant blockade to CpG-induced
activation of tumor-infiltrating DC and macrophages
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Stewart, Charles A.; Trinchieri, Giorgio] NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA.
[Scheetz, Loretta] SAIC Frederick, Canc & Inflammat Program, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 41.51
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600295
ER
PT J
AU Strbo, N
Vaccari, M
Pahwa, S
Kolber, M
Fisher, E
Gonzalez, L
Felber, B
Pavlakis, G
Franchini, G
Podack, E
AF Strbo, Natasa
Vaccari, Monica
Pahwa, Savita
Kolber, Michael
Fisher, Eva
Gonzalez, Louis
Felber, Barbara
Pavlakis, George
Franchini, Genoveffa
Podack, Eckhard
TI Powerful mucosal immune response in macaques (Macaca mulatta) in
response to SIV gp96-Ig immunization
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Strbo, Natasa; Pahwa, Savita; Fisher, Eva; Gonzalez, Louis; Podack, Eckhard] Univ Miami, Miller Sch Med, Microbiol & Immunol, Miami, FL 33136 USA.
[Vaccari, Monica; Franchini, Genoveffa] NCI, Anim Models & Retroviral Vaccines Sect, NIH, Bethesda, MD 20892 USA.
[Kolber, Michael] Univ Miami, Miller Sch Med, Med, Miami, FL 33136 USA.
[Felber, Barbara] NCI, Human Retrovirus Pathogenesis Sect, Frederick, MD 21701 USA.
[Pavlakis, George] NCI, Human Retrovirus Sect, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 39.35
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600156
ER
PT J
AU Subleski, JJ
Hall, VL
Scarzello, AJ
Wolfe, TB
Ortaldo, JR
Hodge, DL
Weiss, JM
Chan, T
Wiltrout, RH
AF Subleski, Jeff J.
Hall, Veronica L.
Scarzello, Anthony J.
Wolfe, Thomas B.
Ortaldo, John R.
Hodge, Deborah L.
Weiss, Jon M.
Chan, Tim
Wiltrout, Robert H.
TI Acute inflammation with 1L-18/1L-12 or alpha-GalCer treatment induces
liver iNKT cell apoptosis and repopulation from peripheral tissues,
whereas chronic inflammation ablates systemic iNKT cells with
thymic-dependent repopulation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Subleski, Jeff J.; Scarzello, Anthony J.; Wolfe, Thomas B.; Ortaldo, John R.; Hodge, Deborah L.; Weiss, Jon M.; Chan, Tim; Wiltrout, Robert H.] NCI, Canc & Inflammat Program, Frederick, MD 21701 USA.
[Hall, Veronica L.] Emergent BioSolut, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 134.24
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602336
ER
PT J
AU Takemoto, C
Noel, P
Mendell, J
Wentzel, E
Carter, M
Metcalfe, DD
Lee, YN
AF Takemoto, Clifford
Noel, Pierre
Mendell, Joshua
Wentzel, Erik
Carter, Melody
Metcalfe, Dean D.
Lee, Youl-Nam
TI KIT Signaling Regulates MITF Expression through microRNAs in
Mastocytosis and Mast Cell Proliferation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Takemoto, Clifford; Lee, Youl-Nam] Johns Hopkins Univ, Pediat Hematol, Baltimore, MD USA.
[Noel, Pierre] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
[Mendell, Joshua; Wentzel, Erik] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD USA.
[Carter, Melody; Metcalfe, Dean D.] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 38.15
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600140
ER
PT J
AU Tang, XB
Tornero, GE
Coligan, JE
Borrego, F
AF Tang, Xiaobin
Tornero, Gloria Esteso
Coligan, John E.
Borrego, Francisco
TI Characterization of the in vivo function of the leukocyte-associated
Ig-like receptor (LAIR)-1
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Tang, Xiaobin; Tornero, Gloria Esteso; Coligan, John E.; Borrego, Francisco] NIAID, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 90.27
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601368
ER
PT J
AU Tarasenko, TN
Bolland, S
AF Tarasenko, Tatiana N.
Bolland, Silvia
TI SHIP deficient macrophages promote inflammation by supporting the
generation of Th17 cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Tarasenko, Tatiana N.; Bolland, Silvia] NIAID, LIG, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 91.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601401
ER
PT J
AU Wan, FY
Lenardo, MJ
AF Wan, Fengyi
Lenardo, Michael J.
TI A novel non-Rel subunit of NF-kB confers its regulatory specificity
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Wan, Fengyi; Lenardo, Michael J.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 136.2
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763602449
ER
PT J
AU Watts, LM
Tassin, TC
Becker, AM
Medeiros, JJ
Albanesi, JP
Love, PE
Wulfing, C
van Oers, NSC
AF Watts, Laura M.
Tassin, Tara C.
Becker, Amy M.
Medeiros, Jennifer J.
Albanesi, Joseph P.
Love, Paul E.
Wulfing, Christoph
van Oers, Nicolai S. C.
TI The CD3 epsilon subunit of the T cell receptor contains a basic-rich
stretch important for multiple T cell functions
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Watts, Laura M.; Becker, Amy M.; Medeiros, Jennifer J.; Wulfing, Christoph; van Oers, Nicolai S. C.] Univ Texas Southwestern Med Ctr, Immunol, Dallas, TX USA.
[Tassin, Tara C.; Albanesi, Joseph P.] Univ Texas Southwestern Med Ctr, Pharmacol, Dallas, TX USA.
[Love, Paul E.] NIH, Mammalian Genes & Dev, Bethesda, MD 20892 USA.
[Wulfing, Christoph] Univ Texas Southwestern Med Ctr, Cell Biol, Dallas, TX USA.
[van Oers, Nicolai S. C.] Univ Texas Southwestern Med Ctr, Microbiol, Dallas, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 85.4
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601249
ER
PT J
AU Xu, H
Yan, YP
Williams, MS
Fowler, DH
Carey, GB
Zhang, GX
Rostami, A
AF Xu, Hui
Yan, Yaping
Williams, Mark S.
Fowler, Daniel H.
Carey, Gregory B.
Zhang, Guang-Xian
Rostami, Abdolmohamad
TI MS4a4B: a novel regulator in T cell proliferation
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Xu, Hui; Yan, Yaping; Zhang, Guang-Xian; Rostami, Abdolmohamad] Thomas Jefferson Univ, Neurol, Philadelphia, PA 19107 USA.
[Williams, Mark S.; Carey, Gregory B.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Fowler, Daniel H.] NCI, Expt Transplantat & Immunol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 82.9
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601192
ER
PT J
AU Yoshimi, R
Chang, TH
Wang, HS
Atsumi, T
Morse, HC
Ozato, K
AF Yoshimi, Ryusuke
Chang, Tsung-Hsien
Wang, Hongsheng
Atsumi, Toru
Morse, Herbert C., III
Ozato, Keiko
TI The expression level of autoantigen TRIM21 changes during lymphocyte
development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Yoshimi, Ryusuke; Chang, Tsung-Hsien; Atsumi, Toru; Ozato, Keiko] NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA.
[Wang, Hongsheng; Morse, Herbert C., III] NIAID, Immunopathol Lab, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 84.10
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601221
ER
PT J
AU Yoshimura, T
Takahashi, M
Galligan, C
Tessarollo, L
AF Yoshimura, Teizo
Takahashi, Munehisa
Galligan, Carole
Tessarollo, Lino
TI Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary
chemokine required for monocyte recruitment in thioglycollate-induced
peritonitis
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Yoshimura, Teizo; Takahashi, Munehisa; Galligan, Carole] NCI, Lab Mol Immunoregulat, Frederick, MD 21701 USA.
[Tessarollo, Lino] NCI, Mouse Canc Genet Program, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 94.5
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601452
ER
PT J
AU Yu, M
Levine, SJ
AF Yu, Man
Levine, Stewart J.
TI Poly (I:C) induces shedding of soluble TNFR1 from human airway
epithelial cells via a TLR3-RIP1-ERK signaling pathway
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Yu, Man; Levine, Stewart J.] NHLBI, Pulm & Vasc Med Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 38.9
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600139
ER
PT J
AU Zamisch, M
Tian, LH
Grenningloh, R
Wildt, KF
Ehlers, M
Ho, IC
Bosselut, R
AF Zamisch, Monica
Tian, Linhua
Grenningloh, Roland
Wildt, Kathryn F.
Ehlers, Marc
Ho, I-Cheng
Bosselut, Remy
TI Ets1 is required for CD4 shut down during CD8 T cell differentiation in
the thymus
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Zamisch, Monica; Wildt, Kathryn F.; Bosselut, Remy] NCI, NIH, Bethesda, MD 20892 USA.
[Tian, Linhua] Bristol Meyers Squibb, Discovery Med & Clincal Pharmacol, Pennington, NJ USA.
[Grenningloh, Roland; Ho, I-Cheng] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
[Ehlers, Marc] DRFZ, Lab Tolerance & Autoimmunigy, Berlin, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 46.11
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600426
ER
PT J
AU Zhang, H
Levine, B
June, C
Mackall, C
AF Zhang, Hua
Levine, Bruce
June, Carl
Mackall, Crystal
TI Peripheral NK Cell Activation and Expansion by Artificial Antigen
Presenting Cells, 2D11
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Zhang, Hua; Mackall, Crystal] NCI, Pediat Oncol, Bethesda, MD 20892 USA.
[Levine, Bruce; June, Carl] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 41.25
PG 2
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763600287
ER
PT J
AU Zhao, ML
Jiang, CC
Diaz, M
AF Zhao, Minglang
Jiang, Chuancang
Diaz, Marilyn
TI Amelioration of Lupus Nephritis in MRL/Ipr mice by Adoptive Transfer of
IgM Anti-dsDNA antibodies
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Zhao, Minglang; Jiang, Chuancang; Diaz, Marilyn] NIEHS, Lab Mol Genet, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2009
VL 182
SU 1
MA 50.28
PG 1
WC Immunology
SC Immunology
GA V44QN
UT WOS:000209763601034
ER
PT J
AU He, Y
AF He, Yi
TI High cell density production of Deinococcus radiodurans under optimized
conditions
SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
LA English
DT Article
DE Deinococcus radiodurans; Growth media; Growth conditions; Design of
experiment; Fermentor
ID MIXED WASTE ENVIRONMENTS; RADIATION; MICROCOCCUS; DEGRADATION;
RESISTANCE; REDUCTION; GROWTH; CR(VI); R1
AB Deinococcus radiodurans is a bacterium being investigated for mechanisms of extreme radiation resistance and for bioremediation of environmental radioactive waste sites. In both fundamental and applied research settings, methods for large-scale production of D. radiodurans are needed. In this study, a systematic investigation was carried out to optimize D. radiodurans production at the 20-L fermentor scale. In defined medium, the phosphate buffer typically used was found to be inhibitory to D. radiodurans growth, and caused cell aggregation. Substitution of HEPES and MOPS buffers for phosphate buffer improved D. radiodurans growth characteristics. Several antifoaming agents were investigated to support large-scale production with submerged aeration, and the defoamer KFO 673 was chosen based on its ability to prevent foaming without affecting D. radiodurans growth. The conventional undefined rich medium tryptone/glucose/yeast extract (TGY) maximally supported D. radiodurans growth to an OD(600) of 10. Using a 'design of experiments' approach, we found glucose, Mg and Mn to be critical in supporting high-density growth of D. radiodurans. The optimal pH and temperature for D. radiodurans growth in large-scale preparations were 7.0 and 37A degrees C, respectively. Growth was carried out in a 20-L fermentor using the newly developed media under the optimal conditions. With addition of 10 g/L glucose, 0.5 g/L MgSO(4) center dot A 7H(2)O, 5 A mu M MnCl(2) into TGY media, an OD(600) of 40 was achieved.
C1 NHLBI, Biochem Lab, Bethesda, MD 20892 USA.
RP He, Y (reprint author), NHLBI, Biochem Lab, Bethesda, MD 20892 USA.
EM hey4@nhlbi.nih.gov
FU National Heart, Lung, and Blood Institute, National Institutes of Health
FX This research was supported by the Intramural Research Program of the
National Heart, Lung, and Blood Institute, National Institutes of
Health.
NR 22
TC 7
Z9 7
U1 5
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1367-5435
J9 J IND MICROBIOL BIOT
JI J. Ind. Microbiol. Biotechnol.
PD APR
PY 2009
VL 36
IS 4
BP 539
EP 546
DI 10.1007/s10295-008-0524-5
PG 8
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 423WP
UT WOS:000264527400008
PM 19137334
ER
PT J
AU Tobian, AAR
Charvat, B
Ssempijja, V
Kigozi, G
Serwadda, D
Makumbi, F
Iga, B
Laeyendecker, O
Riedesel, M
Oliver, A
Chen, MZ
Reynolds, SJ
Wawer, MJ
Gray, RH
Quinn, TC
AF Tobian, Aaron A. R.
Charvat, Blake
Ssempijja, Victor
Kigozi, Godfrey
Serwadda, David
Makumbi, Frederick
Iga, Boaz
Laeyendecker, Oliver
Riedesel, Melissa
Oliver, Amy
Chen, Michael Z.
Reynolds, Steven J.
Wawer, Maria J.
Gray, Ronald H.
Quinn, Thomas C.
TI Factors Associated with the Prevalence and Incidence of Herpes Simplex
Virus Type 2 Infection among Men in Rakai, Uganda
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; GENITAL HERPES; HIV; WORKERS; PERFORMANCE;
TANZANIA
AB Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)
C1 [Tobian, Aaron A. R.] Johns Hopkins Univ, Sch Med, Dept Pathol, Bethesda, MD USA.
[Laeyendecker, Oliver; Oliver, Amy; Reynolds, Steven J.; Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Dept Med, Bethesda, MD USA.
[Charvat, Blake; Chen, Michael Z.; Wawer, Maria J.; Gray, Ronald H.] Johns Hopkins Univ, Dept Populat Family & Reprod Hlth Sci, Bloomberg Sch Publ Hlth, Bethesda, MD USA.
[Laeyendecker, Oliver; Riedesel, Melissa; Reynolds, Steven J.; Quinn, Thomas C.] NIAID, Div Intramural Res, NIH, Bethesda, MD 20892 USA.
[Ssempijja, Victor; Iga, Boaz] Rakai Hlth Sci Program, Entebbe, Uganda.
[Kigozi, Godfrey; Serwadda, David; Makumbi, Frederick] Makerere Univ, Inst Publ Hlth, Kampala, Uganda.
RP Tobian, AAR (reprint author), 855 N Wolfe St,Rm 527, Baltimore, MD 21205 USA.
EM atobian1@jhmi.edu
RI Laeyendecker, Oliver/B-9331-2009;
OI Laeyendecker, Oliver/0000-0002-6429-4760
FU National Institutes of Health [U1AI51171]; Bill and Melinda Gates
Foundation [22006.02]; Fogarty International Center [5D43TW001508,
D43TW00015]; National Institute of Allergy and Infectious Diseases,
National Institutes of Health
FX Financial support: National Institutes of Health (grant U1AI51171 to the
trials); Bill and Melinda Gates Foundation (grant 22006.02 to the
trials); Fogarty International Center (grants 5D43TW001508 and
D43TW00015 to the trials); Intramural Research Program of the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health (support to this study).
NR 15
TC 38
Z9 39
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD APR 1
PY 2009
VL 199
IS 7
BP 945
EP 949
DI 10.1086/597074
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 417DU
UT WOS:000264056600005
PM 19220138
ER
PT J
AU Pearl, P
AF Pearl, P. L.
TI New treatment paradigms in neonatal metabolic epilepsies
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article; Proceedings Paper
CT Annual Symposium of the
Society-for-the-Study-of-Inborn-Errors-of-Metabolism
CY SEP 02-05, 2008
CL Lisbon, PORTUGAL
SP Soc Study Inborn Errors Metabolism
ID PYRIDOXINE-DEPENDENT SEIZURES; ACID-RESPONSIVE SEIZURES; EPILEPTIC
ENCEPHALOPATHY; CEREBROSPINAL-FLUID; GENE; DEFICIENCY; MUTATIONS;
HYPEREKPLEXIA; 5'-PHOSPHATE; DIAGNOSIS
AB Neonatal seizures represent a major challenge among the epilepsies vis-A -vis seizure classification, electroclinical correlation, inherent excitability of neocortex, ontogenic characteristics of neurotransmitter receptors, and responsiveness to standard antiepileptic drugs. Each of these factors renders neonatal seizures more difficult to treat, and therapy has been a vexing area for recent advances in this seizure category. Conversely, specific metabolic disorders have very special therapeutic considerations in the clinical setting of neonatal seizures which require a high index of clinical suspicion and rapid intervention for a successful outcome. The prototype is pyridoxine dependency, although pyridoxal 5'-phosphate dependency is a recently recognized but treatable neonatal epilepsy that deserves earmarked distinction. Clinicians must remain vigilant for these possibilities, including atypical cases where apparent seizure-free intervals may occur. Folinic acid-dependent seizures are allelic with pyridoxine dependency. Serine-dependent seizures and glucose transporter deficiency may present with neonatal seizures and have specific therapy. A vital potassium channel regulated by serum ATP/ADP ratios in the pancreas and brain may be mutated with a resultant neuroendocrinopathy characterized by development delay, epilepsy, and neonatal diabetes (DEND). This requires oral hypoglycaemic therapy, and not insulin, for neurological responsiveness. The startle syndrome of hyperekplexia, which mimics neonatal epilepsy, has been associated with laryngospasm and sudden death but is treated with benzodiazepines.
C1 [Pearl, P. L.] Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA.
[Pearl, P. L.] Natl Inst Neurol Disorders & Stroke, Clin Epilepsy Branch, NIH, Bethesda, MD USA.
[Pearl, P. L.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Clin Res Inst, Washington, DC USA.
[Pearl, P. L.] George Washington Univ, Sch Med, Neuroscience Ctr Excellence, Dept Neurol, Washington, DC USA.
RP Pearl, P (reprint author), Childrens Natl Med Ctr, Dept Neurol, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM ppearl@cnmc.org
NR 54
TC 15
Z9 17
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD APR
PY 2009
VL 32
IS 2
BP 204
EP 213
DI 10.1007/s10545-009-1045-8
PG 10
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 428NX
UT WOS:000264856300007
PM 19234868
ER
PT J
AU Suchy, SF
Cronin, JC
Nussbaum, RL
AF Suchy, S. F.
Cronin, J. C.
Nussbaum, R. L.
TI Abnormal bradykinin signalling in fibroblasts deficient in the PIP(2)
5-phosphatase, ocrl1
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
ID INOSITOL POLYPHOSPHATE 5-PHOSPHATASE; SYNDROME PROTEIN OCRL1;
TRANS-GOLGI NETWORK; LOWE-SYNDROME; 2-AMINOETHOXYDIPHENYL BORATE; ACTIN
POLYMERIZATION; EPITHELIAL-CELLS; PLASMA-MEMBRANE; CA2+ RELEASE;
RECEPTOR
AB The oculocerebrorenal syndrome of Lowe (Lowe syndrome) is an X-linked disorder of phosphatidylinositol metabolism characterized by congenital cataracts, renal proximal tubulopathy and neurological deficits. The disorder is due to the deficiency of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) 5-phosphatase, ocrl1. PIP(2) is critical for numerous cellular processes, including cell signalling, actin reorganization and protein trafficking, and is chronically elevated in patients with Lowe syndrome. The elevation of PIP(2) cells of patients with Lowe syndrome provides the unique opportunity to investigate the roles of this phospholipid in fundamental cellular processes. We previously demonstrated that ocrl1 deficiency causes alterations in the actin cytoskeleton. Since actin remodelling is strongly activated by [Ca(+2)], which increases in response to IP(3) production, we hypothesized that altered calcium signalling might contribute to the observed abnormalities in actin organization. Here we report a specific increase in bradykinin-induced Ca(+2) mobilization in Lowe fibroblasts. We show that the abnormal bradykinin signalling occurs in spite of normal total cellular receptor content. These data point to a novel role for ocrl1 in agonist-induced calcium release.
C1 [Suchy, S. F.; Cronin, J. C.; Nussbaum, R. L.] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
[Suchy, S. F.] GeneDx, Gaithersburg, MD 20877 USA.
[Nussbaum, R. L.] Univ Calif San Francisco, Dept Med, Div Med Genet, San Francisco, CA 94143 USA.
[Nussbaum, R. L.] Univ Calif San Francisco, Dept Med, Inst Human Genet, San Francisco, CA 94143 USA.
RP Suchy, SF (reprint author), GeneDx, 207 Perry Pkwy, Gaithersburg, MD 20877 USA.
EM sharon@genedx.com
FU National Human Genome Research Institute, National Institutes of Health
FX This research was supported by the Intramural Research Program of the
National Human Genome Research Institute, National Institutes of Health.
The authors thank Dr James T. Russell NIH/National Institute of Child
Health and Human Development, for his numerous helpful discussions,
generously sharing advice throughout the course of this project, and for
reviewing the manuscript. We thank Drs Paul Leo and Amalia Dutra for
assistance with the confocal microscope and Julia Fekecs for graphics
assistance. We also thank Dr. Christian Lavedan for thoughtful comments
and critique of the manuscript.
NR 45
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD APR
PY 2009
VL 32
IS 2
BP 280
EP 288
DI 10.1007/s10545-009-1058-3
PG 9
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 428NX
UT WOS:000264856300015
PM 19172411
ER
PT J
AU Cui, CY
Kunisada, M
Esibizione, D
Douglass, EG
Schlessinger, D
AF Cui, Chang-Yi
Kunisada, Makoto
Esibizione, Diana
Douglass, Eric G.
Schlessinger, David
TI Analysis of the Temporal Requirement for Eda in Hair and Sweat Gland
Development
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Article
ID SKIN APPENDAGE DEVELOPMENT; ECTODERMAL DYSPLASIA; FOLLICLE DEVELOPMENT;
SIGNALING PATHWAY; TRANSGENIC MICE; SONIC-HEDGEHOG; SHH EXPRESSION;
ECTODYSPLASIN; PROTEIN; MOUSE
AB EDA signaling is important in skin appendage initiation. Its possible involvement in appendage subtype determination and postinduction stage appendage development, however, has not been studied systematically. To address these issues we manipulated Eda-A1 transgene expression in a tetracycline-regulated conditional mouse model, where the transgene is the only source of active ectodysplasin (Eda). We find that Eda-A1 restores sweat glands and all hair subtypes in Tabby, but each requires its action at an idiosyncratic time of development: by E17 for guard, by E19 for awl, and starting at E18 for zigzag/auchen hair. Guard and awl hairs were indistinguishable from their wild-type counterparts; but restored zigzag and auchen hairs, although recognizable, were somewhat smaller and lacked characteristic bends. Notably, secondary hair follicle formation of awl, auchen, and zigzag hairs required higher Eda-A1 expression level than did guard hair or sweat glands. Furthermore, Eda-A1 expression is required until the early dermal papilla stage for guard hair germs to make follicles, but is dispensable for their maturation. Similarly, sweat gland pegs require Eda-A1 at an early stage to form mature glands. Thus we infer that EDA signaling is needed for the determination and development of various skin appendages at spatiotemporally restricted intervals.
C1 [Cui, Chang-Yi; Kunisada, Makoto; Esibizione, Diana; Douglass, Eric G.; Schlessinger, David] NIA, Genet Lab, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.
[Esibizione, Diana] Univ Bologna, Dept Histol Embryol & Appl Biol, Bologna, Italy.
RP Schlessinger, D (reprint author), NIA, Genet Lab, Biomed Res Ctr, NIH, 251 Bayview Blvd,Suite 100, Baltimore, MD 21224 USA.
EM SchlessingerD@grc.nia.nih.gov
FU NIH; National Institute on Aging
FX We thank R. Nagaraja for critical reading of the paper, and A. Butler
for animal management. This work was supported by the IRP of the NIH,
National Institute on Aging.
NR 45
TC 17
Z9 17
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
IS 4
BP 984
EP 993
DI 10.1038/jid.2008.318
PG 10
WC Dermatology
SC Dermatology
GA 430MW
UT WOS:000264994200023
PM 18923450
ER
PT J
AU Brenner, M
Coelho, SG
Beer, JZ
Miller, SA
Wolber, R
Smuda, C
Hearing, VJ
AF Brenner, Michaela
Coelho, Sergio G.
Beer, Janusz Z.
Miller, Sharon A.
Wolber, Rainer
Smuda, Christoph
Hearing, Vincent J.
TI Long-Lasting Molecular Changes in Human Skin after Repetitive In Situ UV
Irradiation
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Article
ID MESENCHYMAL-EPITHELIAL INTERACTIONS; CUTANEOUS MALIGNANT-MELANOMA;
COLONY-STIMULATING FACTOR; ULTRAVIOLET-B RADIATION; STEM-CELL FACTOR;
HUMAN MELANOCYTES; GENE-EXPRESSION; GROWTH-FACTOR; TUMOR PROGRESSION;
DOWN-REGULATION
AB It is known that UV modulates the expression of paracrine factors that regulate melanocyte function in the skin. We investigated the consequences of repetitive UV exposure of human skin in biopsies of 10 subjects with phototypes 2-3.5 taken 1-4 years later. The expression of melanogenic factors (TYR, MART1, MITF), growth factors/receptors (SCF/KIT, bFGF/FGFR1, ET1/EDNRB, HGF, GM-CSF), adhesion molecules (beta-catenin, E-cadherin, N-cadherin), cell cycle proteins (PCNA, cyclins D1, E2) as well as Bcl-2, DKK1, and DKK3, were analyzed by immunohistochemistry. Most of those markers showed no detectable changes at >= 1 year after the repetitive UV irradiation. Although increased expression of EDNRB protein was detected in 3 of 10 UV-irradiated subjects, there was no detectable change in the expression of ET1 protein or in EDNRB mRNA levels. In summary, only the expression of TYR, MART1, and/or EDNRB, and only in some subjects, was elevated at >= 1 year after UV irradiation. Thus the long-term effects of repetitive UV irradiation on human skin did not lead to significant changes in skin morphology and there is considerable subject-to-subject variation in responses. The possibility that changes in the expression and function of EDNRB triggers downstream activation of abnormal melanocyte proliferation and differentiation deserves further investigation.
C1 [Coelho, Sergio G.; Hearing, Vincent J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA.
[Brenner, Michaela] Univ Munich, Dept Dermatol, D-8000 Munich, Germany.
[Beer, Janusz Z.; Miller, Sharon A.] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA.
[Wolber, Rainer; Smuda, Christoph] Skin Res Beiersdorf AG, R&D, Hamburg, Germany.
RP Hearing, VJ (reprint author), NCI, Cell Biol Lab, NIH, Bldg 37,Room 2132,MSC 4256, Bethesda, MD 20892 USA.
EM hearingv@nih.gov
FU National Cancer Institute; Food and Drug Administration (FDA)
FX This research was supported by the Intramural Research Program of the
National Cancer Institute at NIH, and by the Office of Science, Office
of Women's Health and the Center for Devices and Radiological Health,
Food and Drug Administration (FDA). The authors wish to thank Dr Thierry
Passeron and Dr Itaru Suzuki for their advice and help on the TISH
analysis.
NR 70
TC 10
Z9 10
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
IS 4
BP 1002
EP 1011
DI 10.1038/jid.2008.325
PG 10
WC Dermatology
SC Dermatology
GA 430MW
UT WOS:000264994200025
PM 18946495
ER
PT J
AU Beatrous, SE
Xu, J
Xu, H
Kurundkar, AR
Maheshwari, A
Kopelovich, L
Elmets, CA
Athar, M
AF Beatrous, S. E.
Xu, J.
Xu, H.
Kurundkar, A. R.
Maheshwari, A.
Kopelovich, L.
Elmets, C. A.
Athar, M.
TI Cyclosporine A (CsA), an immunosuppressant, transforms squamous cell
carcinoma (SCC) to a more invasive phenotype: a non-immunological effect
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Beatrous, S. E.; Xu, J.; Xu, H.; Kurundkar, A. R.; Maheshwari, A.; Elmets, C. A.; Athar, M.] Univ Alabama, Birmingham, AL USA.
[Kopelovich, L.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 199
BP S34
EP S34
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000199
ER
PT J
AU Bickers, DR
Tang, X
Zhu, Y
Daly, ME
Liu, WJ
Kopelovich, L
Kim, AL
Athar, M
AF Bickers, D. R.
Tang, X.
Zhu, Y.
Daly, M. E.
Liu, W. J.
Kopelovich, L.
Kim, A. L.
Athar, M.
TI p53-modulating compounds inhibit ultraviolet B (UVB)-induced skin cancer
development in genetically engineered murine models
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Bickers, D. R.; Tang, X.; Zhu, Y.; Daly, M. E.; Liu, W. J.; Kim, A. L.] Columbia Univ, New York, NY USA.
[Athar, M.] Univ Alabama, Birmingham, AL USA.
[Kopelovich, L.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 206
BP S35
EP S35
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000208
ER
PT J
AU Blake, PW
Steinbach, PJ
Toro, JR
AF Blake, P. W.
Steinbach, P. J.
Toro, J. R.
TI CYLD missense mutations occur in USP domain and are associated with
multiple familial trichoepithelioma
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Blake, P. W.; Toro, J. R.] NCI, Bethesda, MD 20892 USA.
[Blake, P. W.] Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20817 USA.
[Steinbach, P. J.] NIH, Ctr Mol Modeling, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 476
BP S80
EP S80
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000478
ER
PT J
AU Bradford, P
Devesa, SS
Anderson, WF
Toro, JR
AF Bradford, P.
Devesa, S. S.
Anderson, W. F.
Toro, J. R.
TI Cutaneous lymphoma incidence patterns in the United States: a
population-based study of 3,884 cases
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Bradford, P.; Toro, J. R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Devesa, S. S.; Anderson, W. F.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 351
BP S59
EP S59
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000350
ER
PT J
AU Bradford, PT
Freedman, DM
Goldstein, AM
Tucker, MA
AF Bradford, P. T.
Freedman, D. M.
Goldstein, A. M.
Tucker, M. A.
TI Increased risk of second primary cancers after diagnosis of melanoma
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Bradford, P. T.; Goldstein, A. M.; Tucker, M. A.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Freedman, D. M.] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
RI Tucker, Margaret/B-4297-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 827
BP S138
EP S138
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000825
ER
PT J
AU Cataisson, C
Wright, L
Maloney, D
Thomas, C
Yuspa, SH
AF Cataisson, C.
Wright, L.
Maloney, D.
Thomas, C.
Yuspa, S. H.
TI Defining and targeting CXCR2 signaling during skin inflammation
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Cataisson, C.; Wright, L.; Yuspa, S. H.] NCI, Lab Canc Biol & Genet, Bethesda, MD 20892 USA.
[Maloney, D.; Thomas, C.] NHGRI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 129
BP S22
EP S22
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000128
ER
PT J
AU Cho, Y
Chae, J
Linton, J
Liu, PP
Feigenbaum, L
Kastner, DL
Katz, SI
AF Cho, Y.
Chae, J.
Linton, J.
Liu, P. P.
Feigenbaum, L.
Kastner, D. L.
Katz, S. I.
TI Familial Mediterranean fever (FMF)-associated mutant B30.2 domain
activates a NALP3-independent inflammasome and induces autoinflammatory
disease in mice
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Cho, Y.; Linton, J.; Katz, S. I.] NCI, Dermatol Branch, Beth, MD USA.
[Liu, P. P.] NHGRI, Genet & Mol Biol Branch, Beth, MD USA.
[Feigenbaum, L.] NCI, Lab Anim Sci Program, Beth, MD USA.
RI Liu, Paul/A-7976-2012
OI Liu, Paul/0000-0002-6779-025X
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 73
BP S13
EP S13
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000073
ER
PT J
AU Coelho, SG
Miller, SA
Zmudzka, BZ
Beer, JZ
Hearing, VJ
AF Coelho, S. G.
Miller, S. A.
Zmudzka, B. Z.
Beer, J. Z.
Hearing, V. J.
TI Melanin dispersion to basal keratinocytes may play a role in UV-induced
long-lasting pigmentation in human skin
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Coelho, S. G.; Hearing, V. J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA.
[Miller, S. A.; Zmudzka, B. Z.; Beer, J. Z.] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 783
BP S131
EP S131
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000782
ER
PT J
AU Cowen, EW
Kesserwan, C
Sokolic, R
Garabedian, E
Baird, K
Wayne, A
Pittaluga, S
Lopez-Terrada, D
Bridge, J
Candotti, F
AF Cowen, E. W.
Kesserwan, C.
Sokolic, R.
Garabedian, E.
Baird, K.
Wayne, A.
Pittaluga, S.
Lopez-Terrada, D.
Bridge, J.
Candotti, F.
TI Multiple dermatofibrosarcoma protuberans (DFSP) in patients with
adenosine deaminase deficiency associated severe combined
immunodeficiency (ADA-SCID)
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Cowen, E. W.; Baird, K.; Wayne, A.; Pittaluga, S.] NCI, Bethesda, MD 20892 USA.
[Kesserwan, C.; Sokolic, R.; Garabedian, E.; Candotti, F.] NHGRI, Bethesda, MD 20892 USA.
[Lopez-Terrada, D.] Baylor Coll Med, Houston, TX 77030 USA.
[Bridge, J.] Univ Nebraska, Omaha, NE 68182 USA.
RI Sokolic, Robert/I-6072-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 164
BP S28
EP S28
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000166
ER
PT J
AU Elmets, CA
Viner, JL
Pentland, AP
Cantrell, W
Bailey, H
Kang, S
Linden, KG
Heffernan, M
Madeleine, D
Elewski, B
Umar, A
Lin, H
Bell, W
Gordon, G
AF Elmets, C. A.
Viner, J. L.
Pentland, A. P.
Cantrell, W.
Bailey, H.
Kang, S.
Linden, K. G.
Heffernan, M.
Madeleine, D.
Elewski, B.
Umar, A.
Lin, H.
Bell, W.
Gordon, G.
TI The cyclooxygenase-2 inhibitor celecoxib effectively suppresses the
development of non-melanoma skin cancers: results of a phase II/III
clinical trial
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Elmets, C. A.; Cantrell, W.; Elewski, B.; Lin, H.; Bell, W.] Univ Alabama, Birmingham, AL USA.
[Bailey, H.] Univ Wisconsin, Madison, WI USA.
[Kang, S.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Linden, K. G.] Univ Calif Irvine, Irvine, CA USA.
[Heffernan, M.] Washington Univ, St Louis, MO USA.
[Madeleine, D.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Viner, J. L.; Umar, A.] NCI, Bethesda, MD 20892 USA.
[Gordon, G.] GD Searle Inc, Skokie, IL USA.
[Pentland, A. P.] Univ Rochester, Rochester, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 325
BP S55
EP S55
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000325
ER
PT J
AU Fang, L
Hwang, ST
AF Fang, L.
Hwang, S. T.
TI Interferon signaling alterations in CCR7-expressing B16 murine melanoma
cells that show diminished recruitment of intratumoral CD8+T cells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Fang, L.; Hwang, S. T.] NCI, Dermatol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 810
BP S135
EP S135
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000810
ER
PT J
AU Gammon, B
Lee, V
Hwang, ST
AF Gammon, B.
Lee, V.
Hwang, S. T.
TI Development of a novel chimeric fusion protein to identify CCR10+cells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Gammon, B.; Lee, V.; Hwang, S. T.] NCI, Bethesda, MD 20892 USA.
[Gammon, B.] Tulane Univ, New Orleans, LA 70118 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 87
BP S15
EP S15
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000086
ER
PT J
AU Gutermuth, J
Nograles, K
Nelson, E
Linton, J
Miyagawa, F
Cho, Y
Katz, SI
AF Gutermuth, J.
Nograles, K.
Nelson, E.
Linton, J.
Miyagawa, F.
Cho, Y.
Katz, S. I.
TI Successful preventive and therapeutic approaches to CD8 T cell-mediated
autoimmunity using self-peptides
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Gutermuth, J.; Nograles, K.; Nelson, E.; Linton, J.; Miyagawa, F.; Cho, Y.; Katz, S. I.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 79
BP S14
EP S14
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000079
ER
PT J
AU Hammerman, S
Carson, P
Panuncialman, J
Herring, D
Falanga, V
AF Hammerman, S.
Carson, P.
Panuncialman, J.
Herring, D.
Falanga, V.
TI Compression regimen for venous leg ulcer patients requiring dressing
changes at least once a day
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Carson, P.; Falanga, V.] NIH, Ctr Biomed Res Excellence, Roger Williams Med Ctr, Providence, RI USA.
[Falanga, V.] Boston Univ, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 278
BP S47
EP S47
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000280
ER
PT J
AU Herman, ML
Farasat, S
Steinbach, PJ
Wei, M
Toure, O
Fleckman, P
Blake, PW
Bale, SJ
Toro, JR
AF Herman, M. L.
Farasat, S.
Steinbach, P. J.
Wei, M.
Toure, O.
Fleckman, P.
Blake, P. W.
Bale, S. J.
Toro, J. R.
TI Transglutaminase-1 gene mutations in autosomal recessive congenital
ichthyosis: A report of 23 novel mutations and modeling of TGase-1
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Herman, M. L.; Farasat, S.; Wei, M.; Toure, O.; Blake, P. W.; Toro, J. R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Steinbach, P. J.] NIH, Ctr Mol Modeling, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
[Wei, M.] SAIC Frederick Inc, Basic Res Program, Frederick, MD USA.
[Fleckman, P.] Univ Washington, Div Med, Dematol Branch, Seattle, WA 98195 USA.
[Blake, P. W.] Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20817 USA.
[Bale, S. J.] GeneDx Inc, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 475
BP S80
EP S80
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000475
ER
PT J
AU Huter, EN
Natarajan, K
Glass, DD
Shevach, EM
AF Huter, E. N.
Natarajan, K.
Glass, D. D.
Shevach, E. M.
TI Autoantibodies in scurfy mice recognize keratins
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Huter, E. N.; Natarajan, K.; Glass, D. D.; Shevach, E. M.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 107
BP S18
EP S18
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000105
ER
PT J
AU Hwang, I
Kalinin, OE
Hwang, M
Morasso, MI
AF Hwang, I.
Kalinin, O. E.
Hwang, M.
Morasso, M. I.
TI Analysis of Scarf expression pattern in LacZ knockin mice
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Hwang, I.; Kalinin, O. E.; Hwang, M.; Morasso, M. I.] NIAMS, Dev Skin Biol Sect, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 629
BP S105
EP S105
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000627
ER
PT J
AU Khan, SG
Oh, K
Inui, H
Emmert, S
Tamura, D
DiGiovanna, JJ
Shahlavi, T
Baker, CC
Schneider, TD
Kraemer, KH
AF Khan, S. G.
Oh, K.
Inui, H.
Emmert, S.
Tamura, D.
DiGiovanna, J. J.
Shahlavi, T.
Baker, C. C.
Schneider, T. D.
Kraemer, K. H.
TI Impaired lariat-loop formation causing abnormal XPC pre-mRNA splicing
resulted in xeroderma pigmentosum
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Khan, S. G.; Oh, K.; Inui, H.; Emmert, S.; Tamura, D.; DiGiovanna, J. J.; Shahlavi, T.; Kraemer, K. H.] NCI, Basic Res Lab, Bethesda, MD 20892 USA.
[Schneider, T. D.] NCI, Nanobiol Program, Frederick, MD 21701 USA.
[DiGiovanna, J. J.] Brown Med Sch, Providence, RI USA.
[Baker, C. C.] NIAMS, Extramural Program, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 168
BP S28
EP S28
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000168
ER
PT J
AU Kim, J
Hwang, J
Suh, J
Morasso, MI
AF Kim, J.
Hwang, J.
Suh, J.
Morasso, M. I.
TI Role of Dlx3 in hair cycling
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Kim, J.; Hwang, J.; Suh, J.; Morasso, M. I.] NIAMS, Dev Skin Biol Sect, NIH, Bethesda, MD USA.
[Kim, J.] Hanyang Univ, Coll Med, Dept Dermatol, Seoul 133791, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 627
BP S105
EP S105
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000626
ER
PT J
AU Kobrin, K
Kwak, T
Yufit, T
Falanga, V
AF Kobrin, K.
Kwak, T.
Yufit, T.
Falanga, V.
TI Media conditioned by human metastatic melanoma cells inhibits in vitro
dermal fibroblast migration
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Kobrin, K.; Kwak, T.; Yufit, T.; Falanga, V.] Roger Williams Med Ctr, Dept Dermatol & Skin Surg, Providence, RI USA.
[Kobrin, K.; Kwak, T.; Yufit, T.; Falanga, V.] Roger Williams Med Ctr, NIH Ctr Biomed Res Excellence, Providence, RI USA.
[Falanga, V.] Boston Univ, Dept Dermatol, Boston, MA 02215 USA.
[Falanga, V.] Boston Univ, Dept Biochem, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 35
BP S6
EP S6
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000033
ER
PT J
AU Kong, HH
Grice, EA
Conlan, SP
Deming, C
Young, AC
Bouffard, GG
Blakesley, RW
Green, ED
Murray, PR
Mijares, L
Turner, ML
Segre, JA
AF Kong, H. H.
Grice, E. A.
Conlan, S. P.
Deming, C.
Young, A. C.
Bouffard, G. G.
Blakesley, R. W.
Green, E. D.
Murray, P. R.
Mijares, L.
Turner, M. L.
Segre, J. A.
TI Diversity profile of the human skin microbiome
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Kong, H. H.; Turner, M. L.] NCI, NIH, Bethesda, MD 20892 USA.
[Grice, E. A.; Conlan, S. P.; Deming, C.; Young, A. C.; Bouffard, G. G.; Blakesley, R. W.; Green, E. D.; Mijares, L.; Segre, J. A.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Murray, P. R.; Mijares, L.] NIH, Microbiol Serv, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 256
BP S43
EP S43
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000257
ER
PT J
AU Kwak, T
Yufit, T
Carson, P
Michalowska, A
Falanga, V
AF Kwak, T.
Yufit, T.
Carson, P.
Michalowska, A.
Falanga, V.
TI A priming in vitro step greatly enhances the repertoire of key genes
involved in epidermal proliferation and migration in bioengineered skin
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Kwak, T.; Yufit, T.; Carson, P.; Falanga, V.] NIH, Ctr Biomed Res Excellence, Roger Williams Med Ctr, Providence, RI USA.
[Michalowska, A.] NIH, Lab Canc Biol & Genet, Bethesda, MD 20892 USA.
[Falanga, V.] Boston Univ, Dept Dermatol & Biochem, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 266
BP S45
EP S45
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000268
ER
PT J
AU Le Pape, E
Passeron, T
Giubellino, A
Valencia, JC
Wolber, R
Hearing, VJ
AF Le Pape, E.
Passeron, T.
Giubellino, A.
Valencia, J. C.
Wolber, R.
Hearing, V. J.
TI The dedifferentiating role of agouti signaling protein in murine
melanocytes via the Mc1r assessed by microarray
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Le Pape, E.; Passeron, T.; Valencia, J. C.; Hearing, V. J.] NIH, LCB, Bethesda, MD 20892 USA.
[Giubellino, A.] NIH, UOB, Bethesda, MD 20892 USA.
[Wolber, R.] Beiersdorf AG, Skin Res, Hamburg, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 853
BP S143
EP S143
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000853
ER
PT J
AU Li, S
Park, H
Trempus, CS
Gordon, D
King, LC
Cotsarelis, G
Morris, RJ
AF Li, S.
Park, H.
Trempus, C. S.
Gordon, D.
King, L. C.
Cotsarelis, G.
Morris, R. J.
TI Heterogeneity in mutant Ha-ras expression within cutaneous papillomas in
mice
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Li, S.; Park, H.; Morris, R. J.] Columbia Univ, Dept Dermatol, New York, NY 10027 USA.
[Trempus, C. S.] NIEHS, Mol Toxicol Lab, Res Triangle Pk, NC 27709 USA.
[Gordon, D.] Rutgers, Dept Genet, Piscataway, NJ USA.
[King, L. C.] EPA, Res Triangle Pk, NC USA.
[Cotsarelis, G.] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 161
BP S27
EP S27
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000159
ER
PT J
AU Li, S
Wang, J
Rajesh, S
Moss, J
Darling, T
AF Li, S.
Wang, J.
Rajesh, S.
Moss, J.
Darling, T.
TI Rapamycin inhibits tumor angiogenesis in a xenograft model of tuberous
sclerosis complex
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Li, S.; Wang, J.; Rajesh, S.; Darling, T.] USUHS, Bethesda, MD USA.
[Moss, J.] NHLBI, Translat Med Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 24
BP S4
EP S4
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000024
ER
PT J
AU Lin, X
Wang, Y
Sun, G
AF Lin, X.
Wang, Y.
Sun, G.
TI In vitro characterization of Src phophorylation of a physiological
substrate, cortactin revealed intriguing features
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Lin, X.] Roger Williams Canc Med Ctr, Ctr Biomed Res Excellence COBRE, Providence, RI USA.
[Lin, X.; Wang, Y.; Sun, G.] Univ Rhode Isl, Kingston, RI 02881 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 543
BP S91
EP S91
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000542
ER
PT J
AU Luo, S
Yufit, T
Carson, P
Falanga, V
AF Luo, S.
Yufit, T.
Carson, P.
Falanga, V.
TI Differential keratin expression during epiboly in an organotypic model
of injury
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Luo, S.; Yufit, T.; Carson, P.; Falanga, V.] Roger Williams Med Ctr, Dept Dermatol, Providence, RI USA.
[Luo, S.; Yufit, T.; Carson, P.; Falanga, V.] Roger Williams Med Ctr, NIH Ctr Biomed Res Excellence, Providence, RI USA.
[Falanga, V.] Boston Univ, Dept Dermatol, Boston, MA 02215 USA.
[Falanga, V.] Boston Univ, Dept Biochem, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 7
BP S2
EP S2
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000008
ER
PT J
AU Mascia, F
Adeva, GS
Yuspa, SH
AF Mascia, F.
Adeva, G. Souto
Yuspa, S. H.
TI Local and systemic inflammation are a consequence of targeted deletion
of epidermal EGFR
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Mascia, F.; Adeva, G. Souto; Yuspa, S. H.] NCI, LCBG, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 120
BP S20
EP S20
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000120
ER
PT J
AU Miyagawa, F
Terunuma, A
Linton, J
Player, A
Edelman, D
Davis, S
Wang, Y
Meltzer, P
Tagaya, Y
Katz, S
AF Miyagawa, F.
Terunuma, A.
Linton, J.
Player, A.
Edelman, D.
Davis, S.
Wang, Y.
Meltzer, P.
Tagaya, Y.
Katz, S.
TI IL-15 regulates a critical checkpoint by stabilizing gene expression in
autoreactive CD8Tcells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Miyagawa, F.; Terunuma, A.; Linton, J.; Katz, S.] NIH, Dermatol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 688
BP S115
EP S115
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000689
ER
PT J
AU Moslehi, R
Signore, C
Tamura, D
Mills, JL
DiGiovanna, JJ
Tucker, MA
Troendle, J
Goldstein, A
Kraemer, KH
AF Moslehi, R.
Signore, C.
Tamura, D.
Mills, J. L.
DiGiovanna, J. J.
Tucker, M. A.
Troendle, J.
Goldstein, A.
Kraemer, K. H.
TI A genetic epidemiologic investigation of gestational outcomes associated
with the DNA repair disorder, trichothiodystrophy
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Moslehi, R.; Tamura, D.; DiGiovanna, J. J.; Tucker, M. A.; Goldstein, A.; Kraemer, K. H.] NCI, NIH, Bethesda, MD 20892 USA.
[Moslehi, R.] SUNY Albany, Albany, NY 12222 USA.
[Signore, C.; Mills, J. L.; Troendle, J.] NICHD, NIH, Bethesda, MD USA.
RI Tucker, Margaret/B-4297-2015
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 350
BP S59
EP S59
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000352
ER
PT J
AU Motegi, S
DeWitt, C
Leitner, W
Nagao, K
Udey, MC
AF Motegi, S.
DeWitt, C.
Leitner, W.
Nagao, K.
Udey, M. C.
TI Localization of MFG-E8 (milk fat globule-associated protein with EGF-
and Factor VIII-like domains) in normal murine skin
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Motegi, S.; DeWitt, C.; Leitner, W.; Nagao, K.; Udey, M. C.] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 428
BP S72
EP S72
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000430
ER
PT J
AU Nagao, K
Zhu, J
Hanson, J
Morasso, MI
Tessarollo, L
Mackem, S
Udey, MC
AF Nagao, K.
Zhu, J.
Hanson, J.
Morasso, M. I.
Tessarollo, L.
Mackem, S.
Udey, M. C.
TI Critical roles for EpCAM (epithelial cell adhesion molecule) for early
embryogensis and placental development
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Nagao, K.; Udey, M. C.] NIH, Dermatol Branch, Bethesda, MD 20892 USA.
[Tessarollo, L.] NIH, Mouse Canc Genet Program, Bethesda, MD 20892 USA.
[Morasso, M. I.] NIH, Dev Skin Biol Unit, Bethesda, MD 20892 USA.
[Nagao, K.] Keio Univ, Sch Med, Tokyo, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 215
BP S36
EP S36
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000213
ER
PT J
AU Oh, K
Imoto, K
Emmert, S
Tamura, D
DiGiovanna, JJ
Kraemer, KH
AF Oh, K.
Imoto, K.
Emmert, S.
Tamura, D.
DiGiovanna, J. J.
Kraemer, K. H.
TI Recruitment and redistribution of nucleotide excision repair factors in
XP-E cells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Oh, K.; Imoto, K.; Tamura, D.; DiGiovanna, J. J.; Kraemer, K. H.] NCI, Basic Res Lab, Bethesda, MD 20892 USA.
[Emmert, S.] Goettingen Univ, Dept Derm, Gottingen, Germany.
[DiGiovanna, J. J.] Brown Med Sch, Dept Derm, Providence, RI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 193
BP S33
EP S33
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000193
ER
PT J
AU Panuncialman, J
Hammerman, S
Carson, P
Falanga, V
AF Panuncialman, J.
Hammerman, S.
Carson, P.
Falanga, V.
TI Wound edge biopsy sites in chronic wounds heal rapidly and do not result
in delayed wound healing
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Panuncialman, J.; Hammerman, S.; Carson, P.; Falanga, V.] Roger Williams Med Ctr, Dept Dermatol & Skin Surg, Providence, RI USA.
[Hammerman, S.; Carson, P.; Falanga, V.] NIH, Ctr Biomed Res Excellence, Roger Williams Med Ctr, Providence, RI USA.
[Falanga, V.] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA.
[Falanga, V.] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA.
NR 0
TC 2
Z9 2
U1 1
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 281
BP S47
EP S47
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000279
ER
PT J
AU Patel, GK
Yee, CL
Montemarano, A
Maggio, K
Vogel, JC
AF Patel, G. K.
Yee, C. L.
Montemarano, A.
Maggio, K.
Vogel, J. C.
TI CD133 identifies human cutaneous squamous cell carcinoma tumor
initiating cells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Patel, G. K.] Cardiff Univ, Sch Med, Cardiff, S Glam, Wales.
[Patel, G. K.; Yee, C. L.; Vogel, J. C.] NCI, Dermatol Branch, Bethesda, MD 20892 USA.
[Montemarano, A.] Rockledge Skin Canc Clin, Bethesda, MD USA.
[Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 155
BP S26
EP S26
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000153
ER
PT J
AU Purwar, R
Jetten, A
Kupper, TS
AF Purwar, R.
Jetten, A.
Kupper, T. S.
TI Deficiency of Retinoid related Orphan Receptor (ROR). blocks the
evolution of Th17 T cells and abrogates the contact hypersensitivity
response (CHS), despite intact immunity and IFN gamma production in
response to CHS antigens
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Purwar, R.; Kupper, T. S.] Harvard Skin Dis Res Ctr, Boston, MA USA.
[Jetten, A.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 692
BP S116
EP S116
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000694
ER
PT J
AU Sadowski, S
Li, Q
Varadi, A
Ho, SY
Dean, M
Uitto, J
AF Sadowski, S.
Li, Q.
Varadi, A.
Ho, S. Y.
Dean, M.
Uitto, J.
TI Morpholino "knockdown" of the Abcc6a gene impairs zebrafish development
- a model system for PXE
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Sadowski, S.; Li, Q.; Uitto, J.] Thomas Jefferson Univ, Jefferson Med Coll, Jefferson Inst Mol Med, Philadelphia, PA 19107 USA.
[Varadi, A.] Hungarian Acad Sci, Budapest, Hungary.
[Ho, S. Y.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA.
[Dean, M.] NCI, Frederick Canc Res & Dev Ctr, Human Genet Sect, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 502
BP S84
EP S84
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000503
ER
PT J
AU Sarihan, M
Khan, SG
Mendelsohn, NJ
Boyle, J
Tamura, D
DiGiovanna, JJ
Brooks, BP
Merideth, M
Kraemer, KH
AF Sarihan, M.
Khan, S. G.
Mendelsohn, N. J.
Boyle, J.
Tamura, D.
DiGiovanna, J. J.
Brooks, B. P.
Merideth, M.
Kraemer, K. H.
TI Trichothiodystrophy patients with XPD mutations and features of COFS or
features of Cockayne syndrome
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Sarihan, M.; Khan, S. G.; Boyle, J.; Tamura, D.; DiGiovanna, J. J.; Kraemer, K. H.] NCI, Basic Res Lab, Bethesda, MD 20892 USA.
[Sarihan, M.] NIH, CRTP Fellowship Program, Bethesda, MD 20892 USA.
[Mendelsohn, N. J.] Childerens Hosp & Clin Minnesota, Dept Genet, Minneapolis, MN USA.
[DiGiovanna, J. J.] Brown Med Sch, Dept Derm, Providence, RI USA.
[Brooks, B. P.] NEI, NIH, Bethesda, MD 20892 USA.
[Merideth, M.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 618
BP S103
EP S103
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000618
ER
PT J
AU Shukla, A
Madanikia, S
Yuspa, SH
AF Shukla, A.
Madanikia, S.
Yuspa, S. H.
TI CLIC4 regulates TGF-beta dependent myofibroblast conversion of dermal
fibroblasts
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Shukla, A.; Madanikia, S.; Yuspa, S. H.] NCI, Lab Canc Biol & Genet, NIH, Bethesda, MD 20892 USA.
RI Shukla, Anjali/G-4046-2014
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 23
BP S4
EP S4
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000021
ER
PT J
AU Strong, CD
Sears, K
Segre, JA
AF Strong, C. de Guzman
Sears, K.
Segre, J. A.
TI Identification of cis-regulatory elements in the epidermal
differentiation complex (EDC)
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Strong, C. de Guzman; Segre, J. A.] NHGRI, Bethesda, MD 20892 USA.
[Sears, K.] Univ Illinois, Urbana, IL 61801 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 536
BP S90
EP S90
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000538
ER
PT J
AU Tang, X
Zhu, Y
Back, JH
Kopelovich, L
Athar, M
Kim, AL
Bickers, DR
AF Tang, X.
Zhu, Y.
Back, J. H.
Kopelovich, L.
Athar, M.
Kim, A. L.
Bickers, D. R.
TI Resveratrol suppresses ultraviolet B (UVB)-induced basal cell carcinoma
(BCC) growth via cyclin D1 modulation in Ptc1+/-/SKH-1 mice
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Tang, X.; Zhu, Y.; Back, J. H.; Kim, A. L.; Bickers, D. R.] Columbia Univ, New York, NY 10027 USA.
[Athar, M.] Univ Alabama, Birmingham, AL USA.
[Kopelovich, L.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 204
BP S34
EP S34
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000204
ER
PT J
AU Wang, Y
DiGiovanna, JJ
Lee, C
Jere, SB
Raffeld, M
Jaffe, ES
Kraemer, KH
AF Wang, Y.
DiGiovanna, J. J.
Lee, C.
Jere, S. B.
Raffeld, M.
Jaffe, E. S.
Kraemer, K. H.
TI Genetic instability in metastatic melanoma from a patient with xeroderma
pigmentosum
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Wang, Y.; DiGiovanna, J. J.; Kraemer, K. H.] NCI, Basic Res Lab, Bethesda, MD 20892 USA.
[Lee, C.; Jere, S. B.; Raffeld, M.; Jaffe, E. S.] NCI, Pathol Lab, Bethesda, MD 20892 USA.
[DiGiovanna, J. J.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 828
BP S138
EP S138
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000828
ER
PT J
AU Wolf, R
Dong, H
Voscopoulos, C
Winston, J
Gunsior, M
Goldsmith, P
Cataisson, C
Chavakis, T
Howard, O
Oppenheim, JJ
Yuspa, SH
AF Wolf, R.
Dong, H.
Voscopoulos, C.
Winston, J.
Gunsior, M.
Goldsmith, P.
Cataisson, C.
Chavakis, T.
Howard, O.
Oppenheim, J. J.
Yuspa, S. H.
TI Evolutionary conserved chemotactic activity of S100A7 (psoriasin) is
mediated by RAGE and potentiates inflammation with highly homologous but
functionally distinct S100A15
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Wolf, R.; Voscopoulos, C.; Winston, J.; Cataisson, C.; Yuspa, S. H.] NCI, Lab Canc Biol & Genet, Bethesda, MD 20892 USA.
[Dong, H.] NCI, SAIC Frederick, Div Basic Sci & Cellular Immunol, Frederick, MD 21701 USA.
[Chavakis, T.] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA.
[Howard, O.; Oppenheim, J. J.] NCI, Mol Immunoregulat Lab, Frederick, MD 21701 USA.
[Gunsior, M.; Goldsmith, P.] NCI, Antibody & Prot Purificat Unit, Bethesda, MD 20892 USA.
[Wolf, R.] Univ Munich, Dept Dermatol & Allergol, Munich, Germany.
RI Howard, O M Zack/B-6117-2012
OI Howard, O M Zack/0000-0002-0505-7052
NR 0
TC 1
Z9 1
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 90
BP S15
EP S15
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000090
ER
PT J
AU Wu, X
Hwang, S
AF Wu, X.
Hwang, S.
TI Dinitrofluorobenzene (DNFB) promotes the development of a high-grade,
aggressive lymphoma by MBL2 murine T cells in skin
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Wu, X.; Hwang, S.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 154
BP S26
EP S26
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000155
ER
PT J
AU Yufit, T
Carson, P
Kwak, T
Iwamoto, S
Fiore, D
Falanga, V
AF Yufit, T.
Carson, P.
Kwak, T.
Iwamoto, S.
Fiore, D.
Falanga, V.
TI Development of a good manufacturing practice (GMP) facility
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Yufit, T.; Carson, P.; Kwak, T.; Iwamoto, S.; Fiore, D.; Falanga, V.] NIH, Ctr Biomed Res Excellence, Roger Williams Med Ctr, Providence, RI USA.
[Falanga, V.] Boston Univ, Dept Dermatol & Biochem, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 267
BP S45
EP S45
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000266
ER
PT J
AU Zhang, H
Lee, V
Hwang, S
AF Zhang, H.
Lee, V.
Hwang, S.
TI Doxycycline (Dox)-inducible expression of CXC chemokine receptor-4
(CXCR4) in B16 melanoma cells reveals roles for CXCR4 in lung and lymph
node (LN) metastasis
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Zhang, H.; Lee, V.; Hwang, S.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 808
BP S135
EP S135
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000809
ER
PT J
AU Zhao, BM
Hornyak, TJ
AF Zhao, B. M.
Hornyak, T. J.
TI Inhibition of cell proliferation by BMI-1 depletion in human melanoma
cells
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Zhao, B. M.; Hornyak, T. J.] NCI, Dermatol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 856
BP S143
EP S143
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000857
ER
PT J
AU Gao, F
Kiesewetter, D
Chang, L
Ma, K
Bell, JM
Rapoport, SI
Igarashi, M
AF Gao, Fei
Kiesewetter, Dale
Chang, Lisa
Ma, Kaizong
Bell, Jane M.
Rapoport, Stanley I.
Igarashi, Miki
TI Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from
circulating unesterified alpha-linolenic acid in unanesthetized rats
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE docosahexaenoic acid; stable isotopes; liver; esterified; rat; kinetics
ID POLYUNSATURATED FATTY-ACIDS; LOW-DENSITY-LIPOPROTEIN; DOCOSAHEXAENOIC
ACID; BRAIN PHOSPHOLIPIDS; NUTRITIONAL DEPRIVATION; MASS-SPECTROMETRY;
ARACHIDONIC-ACID; LIVER CONVERSION; NERVOUS-SYSTEM; PLASMA-VOLUME
AB Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), long-chain n-3 PUFAs important for brain and heart function, can be obtained from dietary fish products or by liver synthesis from a-linolenic acid (alpha-LNA). Their daily human dietary requirements are not clear, and their liver synthesis rates in humans and nonhumans are unknown. We estimated whole-body (presumably liver) synthesis rates in unanesthetized rats by infusing [U-(13)C]alpha-LNA intravenously for 2 h and measuring labeled and unlabeled n-3 PUFA in arterial plasma using negative chemical ionization GC-MS. Newly synthesized esterified [(13)C] DHA, [(13)C] EPA, and [(13)C] docosapentaenoic acid (DPA) appeared in arterial plasma after 60 min of infusion, then their concentrations rose in an S-shaped manner. Esterified concentration x plasma volume data were fit with a sigmoidal equation, whose peak first derivatives provided synthesis rates of unlabeled EPA, DPA, and DHA equal to 8.40, 6.27, and 9.84 mmol/day, respectively. The DHA synthesis rate exceeded the published daily rat brain DHA consumption rate by 30-fold, suggesting that liver synthesis from alpha-LNA could maintain brain DHA homeostasis were DHA absent from the diet. This stable isotope infusion method could be used to quantify whole-body DHA synthesis rates in human subjects.-Gao, F., D. Kiesewetter, L. Chang, K. Ma, J. M. Bell, S. I. Rapoport, and M. Igarashi. Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats. J. Lipid Res. 2009. 50: 749-758.
C1 [Gao, Fei; Chang, Lisa; Ma, Kaizong; Bell, Jane M.; Rapoport, Stanley I.; Igarashi, Miki] NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA.
[Kiesewetter, Dale] Natl Inst Biomed Imaging & Bioengn, Positron Emiss Tomog Radiochem Grp, NIH, Bethesda, MD 20892 USA.
RP Gao, F (reprint author), NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA.
EM gaof@mail.nih.gov
FU Intramural Research Programs of the National Institutes on Aging;
Biomedical Imaging and Bioengineering, National Institutes of Health,
Bethesda, MD
FX This research was supported by the Intramural Research Programs of the
National Institutes on Aging and of Biomedical Imaging and
Bioengineering, National Institutes of Health, Bethesda, MD.
NR 67
TC 32
Z9 33
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0022-2275
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
IS 4
BP 749
EP 758
DI 10.1194/jlr.D800056-JLR200
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 420IV
UT WOS:000264283800018
PM 19074373
ER
PT J
AU Persaud-Sawin, DA
Lightcap, S
Harry, GJ
AF Persaud-Sawin, Dixie-Ann
Lightcap, Samantha
Harry, G. Jean
TI Isolation of rafts from mouse brain tissue by a detergent-free method
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE lipid-rich compartments; Flotillin 1; liquid-disordered phase; membrane
ID RICH MEMBRANE DOMAINS; GPI-ANCHORED PROTEINS; MYELIN BASIC-PROTEIN;
LIPID RAFTS; CELL-SURFACE; SIGNAL-TRANSDUCTION; MICRODOMAINS;
CHOLESTEROL; CAVEOLAE; GANGLIOSIDES
AB Membrane rafts are rich in cholesterol and sphingolipids and have specific proteins associated with them. Due to their small size, their identification and isolation have proved to be problematic. Their insolubility in nonionic detergents, such as Triton-X 100, at 4 degrees C has been the most common means of isolation. However, detergent presence can produce artifacts or interfere with ganglioside distribution. The direction is therefore toward the use of detergent-free protocols. We report an optimized method of raft isolation from lipid-rich brain tissue using a detergent-free method. We compared this to Triton-X 100-based isolation along sucrose or Optiprep (TM) gradients using the following endpoints: low protein content, high cholesterol content, presence of Flotillin 1 (Flot1), and absence of transferrin receptor (TfR) proteins. These criteria were met in raft fractions isolated in a detergent-free buffer along a sucrose gradient of 5%/35%/42.5%. The use of optiprep gave less consistent results with respect to protein distribution. We demonstrate that clean raft fractions with minimal myelin contamination can be reproducibly obtained in the top three low-density fractions along a sucrose step gradient. Persaud-Sawin, D-A., S. Lightcap, and G. J. Harry. Isolation of rafts from mouse brain tissue by a detergent-free method. J. Lipid Res. 2009. 50: 759-767.
C1 [Persaud-Sawin, Dixie-Ann; Lightcap, Samantha; Harry, G. Jean] Natl Inst Environm Hlth Sci, Lab Mol Toxicol Neurotoxicol Grp, Res Triangle Pk, NC 27709 USA.
RP Persaud-Sawin, DA (reprint author), Natl Inst Environm Hlth Sci, Lab Mol Toxicol Neurotoxicol Grp, Res Triangle Pk, NC 27709 USA.
EM sawind@niehs.nih.gov
FU Intramural Research Program of the National Institutes of Health;
National Institute of Environmental Health Sciences [1Z01ES101623-05]
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences under project # 1Z01ES101623-05.
NR 56
TC 24
Z9 25
U1 0
U2 6
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0022-2275
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
IS 4
BP 759
EP 767
DI 10.1194/jlr.D800037-JLR200
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 420IV
UT WOS:000264283800019
PM 19060326
ER
PT J
AU Maceyka, M
Milstien, S
Spiegel, S
AF Maceyka, Michael
Milstien, Sheldon
Spiegel, Sarah
TI Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE ceramide; ceramide synthase; sphingosine kinase; sphingosine-1-phosphate
phosphohydrolase; sphingosine-1-phosphate receptor
ID SPHINGOSINE KINASE 1; IMATINIB-INDUCED APOPTOSIS; MYELOID-LEUKEMIA
CELLS; DEPENDENT TRANSLOCATION; LYMPHOCYTE EGRESS; PLASMA-MEMBRANE;
CANCER CELL; 1-PHOSPHATE; ACTIVATION; BLOOD
AB The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease. Activation of sphingosine kinases (SphKs) by a variety of agonists increases intracellular S1P, which in turn can be secreted out of the cell and bind to and signal through S1P receptors (S1PRs) in an autocrine and/or paracrine manner. Recent studies suggest that this "inside-out" signaling by S1P may play a role in many human diseases. As the roles of the S1PRs in cell and organismal physiology are discussed elsewhere in this volume, we focus this review mainly on recent reports showing how SphKs are activated and S1P reaches its receptors, the role of SphKs and S1P in regulating sphingolipid homeostasis, and the potential importance of the SphK/S1P axis as a therapeutic target in human diseases.-Maceyka, M., S. Milstien, and S. Spiegel. Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J. Lipid Res. 2009. S272-S276.
C1 [Maceyka, Michael; Spiegel, Sarah] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA.
[Milstien, Sheldon] NIMH, Bethesda, MD 20892 USA.
RP Spiegel, S (reprint author), Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM sspiegel@vcu.edu
FU National Institutes of Health [R37GM043880, RO1CA61774, RO1AI050094,
U19AI077435-018690]
FX Supported by National Institutes of Health Grants R37GM043880,
RO1CA61774, RO1AI050094, and U19AI077435-018690 (SS) and the NIMH
Intramural Research Program (SM).
NR 47
TC 66
Z9 68
U1 0
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0022-2275
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
BP S272
EP S276
DI 10.1194/jlr.R800065-JLR200
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 432JD
UT WOS:000265128400047
PM 18987387
ER
PT J
AU Koay, CG
Ozarslan, E
Basser, PJ
AF Koay, Cheng Guan
Oezarslan, Evren
Basser, Peter J.
TI A signal transformational framework for breaking the noise floor and its
applications in MRI
SO JOURNAL OF MAGNETIC RESONANCE
LA English
DT Article
DE MR noise floor; Signal transformation; Rician; NonCentral Chi; Gaussian;
MRI
ID MAGNETIC-RESONANCE IMAGES; AUTOMATIC PHASE CORRECTION; DIFFUSION;
RESOLUTION; VARIANCE; RECONSTRUCTION; DISTRIBUTIONS; SYSTEMS; BRAIN
AB A long-standing problem in magnetic resonance imaging (MRI) is the noise-induced bias in the magnitude signals. This problem is particularly pressing in diffusion MRI at high diffusion-weighting. In this paper, we present a three-stage scheme to solve this problem by transforming noisy nonCentral Chi signals to noisy Gaussian signals. A special case of nonCentral Chi distribution is the Rician distribution. In general, the Gaussian-distributed signals are of interest rather than the Gaussian-derived (e.g., Rayleigh, Rician, and nonCentral Chi) signals because the Gaussian-distributed signals are generally more amenable to statistical treatment through the principle of least squares. Monte Carlo simulations were used to validate the statistical properties of the proposed framework. This scheme opens up the possibility of investigating the low signal regime (or high diffusion-weighting regime in the case of diffusion MRI) that contains potentially important information about biophysical processes and structures of the brain. Published by Elsevier Inc.
C1 [Koay, Cheng Guan; Oezarslan, Evren; Basser, Peter J.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Tissue Biophys & Biomimet, Bethesda, MD 20892 USA.
RP Koay, CG (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Tissue Biophys & Biomimet, Bldg 13,Rm 3W16,13 South Dr,MSC 5772, Bethesda, MD 20892 USA.
EM guankoac@mail.nih.gov
RI Ozarslan, Evren/B-4858-2013; Basser, Peter/H-5477-2011
OI Ozarslan, Evren/0000-0003-0859-1311;
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development; National Institute on Drug Abuse; National Institute of
Mental Health; National Institute of Neurological Disorders and Stroke;
NIH Neuroscience Blueprint
FX We are grateful to Liz Salak for reviewing the paper. C.G. Koay was
supported in part by the Eunice Kennedy Shriver National Institute of
Child Health and Human Development, the National Institute on Drug
Abuse, the National Institute of Mental Health, and the National
Institute of Neurological Disorders and Stroke as part of the NIH MRI
Study of Normal Pediatric Brain Development with supplemental funding
from the NIH Neuroscience Blueprint. We thank Drs. Timothy M. Shepherd
and Stephen J. Blackband for the MRI data set.
NR 46
TC 47
Z9 47
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1090-7807
J9 J MAGN RESON
JI J. Magn. Reson.
PD APR
PY 2009
VL 197
IS 2
BP 108
EP 119
DI 10.1016/j.jmr.2008.11.015
PG 12
WC Biochemical Research Methods; Physics, Atomic, Molecular & Chemical;
Spectroscopy
SC Biochemistry & Molecular Biology; Physics; Spectroscopy
GA 427JK
UT WOS:000264775400002
PM 19138540
ER
PT J
AU Hyodo, F
Matsumoto, S
Devasahayam, N
Dharmaraj, C
Subramanian, S
Mitchell, JB
Krishna, MC
AF Hyodo, Fuminori
Matsumoto, Shingo
Devasahayam, Nallathamby
Dharmaraj, Christopher
Subramanian, Sankaran
Mitchell, James B.
Krishna, Murali C.
TI Pulsed EPR imaging of nitroxides in mice
SO JOURNAL OF MAGNETIC RESONANCE
LA English
DT Article
DE Nitroxide; Oximetry; Pulsed EPR; Redox; Single point imaging
ID ELECTRON-PARAMAGNETIC-RESONANCE; SENSITIVE CONTRAST AGENTS;
OVERHAUSER-ENHANCED MRI; TUMOR REDOX STATUS; TIME-DOMAIN EPR; RADICALS;
OXYGENATION; RESOLUTION
AB Nitroxides, unlike trityl radicals, have shorter T(2)s which until now were not detectable in vivo by a time-domain Pulsed Electron Paramagnetic Resonance (EPR) spectrometer at 300 MHz since their phase memory times were shorter than the spectrometer recovery times. In the current version of the time-domain EPR spectrometer with improved spectrometer recovery times, the feasibility of detecting signals from nitroxide radicals was tested. Among the nitroxides evaluated, deuterated (15)N-Tempone ((15)N-PDT) was found to have the longest T(2). The signal intensity profile as a function of concentration of these agents was evaluated and a biphasic behavior was observed; beyond a nitroxide concentration of 1.5 mM, signal intensity was found to decrease as a result of self-broadening. Imaging experiments were carried out with (15)N-PDT in Solutions equilibrated with 0%, 5%, 10%, and 21% oxygen using the single point imaging (SPI) modality in EPR. The image intensity in these tubes was found to depend on the oxygen concentration which in turn influences the T(2) of (15)N-PDT. In vivo experiments were demonstrated with (15)N-PDT in anesthetized mice where the distribution and metabolism of (15)N-PDT could be monitored. This study, for the first time shows the capability to image a cell-permeable nitroxide in mice using pulsed EPR in the SPI modality. (C) 2009 Published by Elsevier Inc.
C1 [Hyodo, Fuminori; Matsumoto, Shingo; Devasahayam, Nallathamby; Dharmaraj, Christopher; Subramanian, Sankaran; Mitchell, James B.; Krishna, Murali C.] NCI, NIH, Radiat Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Hyodo, Fuminori] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka 812, Japan.
RP Matsumoto, S (reprint author), NCI, NIH, Radiat Biol Branch, Ctr Canc Res, 9000 Rockville Pike,Bldg 10,Room B3B69, Bethesda, MD 20892 USA.
EM matsumo@mail.nih.gov
FU Intramural Research Program, Center for Cancer Research, National Cancer
Institute, NIH
FX This work was supported by the Intramural Research Program, Center for
Cancer Research, National Cancer Institute, NIH.
NR 21
TC 29
Z9 29
U1 1
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1090-7807
J9 J MAGN RESON
JI J. Magn. Reson.
PD APR
PY 2009
VL 197
IS 2
BP 181
EP 185
DI 10.1016/j.jmr.2008.12.018
PG 5
WC Biochemical Research Methods; Physics, Atomic, Molecular & Chemical;
Spectroscopy
SC Biochemistry & Molecular Biology; Physics; Spectroscopy
GA 427JK
UT WOS:000264775400010
PM 19157932
ER
PT J
AU Yu, RR
Cheng, AT
Lagenaur, LA
Huang, WJ
Weiss, DE
Treece, J
Sanders-Beer, BE
Hamer, DH
Lee, PP
Xu, Q
Liu, Y
AF Yu, Rosa R.
Cheng, Andrew T.
Lagenaur, Laurel A.
Huang, Wenjun
Weiss, Deborah E.
Treece, Jim
Sanders-Beer, Brigitte E.
Hamer, Dean H.
Lee, Peter P.
Xu, Qiang
Liu, Yang
TI A Chinese rhesus macaque (Macaca mulatta) model for vaginal
Lactobacillus colonization and live microbicide development
SO JOURNAL OF MEDICAL PRIMATOLOGY
LA English
DT Article
DE bacterial colonization; Chinese rhesus macaques; Lactobacillus
johnsonii; live microbial microbicide; vaginal microflora
ID BACTERIAL VAGINOSIS; GENITAL-TRACT; ACIDOPHILUS GROUP; CYANOVIRIN-N;
2-DOMAIN CD4; MOUSE MODEL; WOMEN; FLORA; IDENTIFICATION; TRANSMISSION
AB We sought to establish a nonhuman primate model of vaginal Lactobacillus colonization suitable for evaluating live microbial microbicide candidates.
Vaginal and rectal microflora in Chinese rhesus macaques (Macaca mulatta) were analyzed, with cultivable bacteria identified by 16S rRNA gene sequencing. Live lactobacilli were intravaginally administered to evaluate bacterial colonization.
Chinese rhesus macaques harbored abundant vaginal Lactobacillus, with Lactobacillus johnsonii as the predominant species. Like humans, most examined macaques harbored only one vaginal Lactobacillus species. Vaginal and rectal Lactobacillus isolates from the same animal exhibited different genetic and biochemical profiles. Vaginal Lactobacillus was cleared by a vaginal suppository of azithromycin, and endogenous L. johnsonii was subsequently restored by intravaginal inoculation. Importantly, prolonged colonization of a human vaginal Lactobacillus jensenii was established in these animals.
The Chinese rhesus macaque harbors vaginal Lactobacillus and is a potentially useful model to support the pre-clinical evaluation of Lactobacillus-based topical microbicides.
C1 [Yu, Rosa R.; Cheng, Andrew T.; Lagenaur, Laurel A.; Huang, Wenjun; Lee, Peter P.; Xu, Qiang; Liu, Yang] Osel Inc, Santa Clara, CA 95054 USA.
[Weiss, Deborah E.; Treece, Jim] Adv BioSci Labs Inc, Kensington, MD USA.
[Sanders-Beer, Brigitte E.] So Res Inst, Frederick, MD USA.
[Hamer, Dean H.] NCI, NIH, Bethesda, MD 20892 USA.
RP Xu, Q (reprint author), Osel Inc, 4008 Burton Dr, Santa Clara, CA 95054 USA.
EM qxu@oselinc.com; yliu@oselinc.com
FU NIH [U19AI60615]; NIH Partnerships for Topical Microbicides
[U01AI066708]
FX This work was supported in part by NIH Integrated Preclinical/Clinical
Program for Topical Microbicides U19AI60615 and NIH Partnerships for
Topical Microbicides U01AI066708. The authors thank Lorna K. Rabe at
Magee-Womens Research Institute for technical advice in quantitative
microbiology, Dr. Dusty Rhodes and Dawn Golightly at Southern Research
Institute for their guidance and assistance in macaque studies, and Dr.
Xiaowen Liu for critical reading of this manuscript.
NR 50
TC 17
Z9 18
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0047-2565
J9 J MED PRIMATOL
JI J. Med. Primatol.
PD APR
PY 2009
VL 38
IS 2
BP 125
EP 136
DI 10.1111/j.1600-0684.2008.00316.x
PG 12
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 418YP
UT WOS:000264186400009
PM 19367737
ER
PT J
AU Freeman, MM
Kerin, T
Hull, J
Teel, E
Esona, M
Parashar, U
Glass, RI
Gentsch, JR
AF Freeman, M. M.
Kerin, T.
Hull, J.
Teel, E.
Esona, M.
Parashar, U.
Glass, R. I.
Gentsch, J. R.
TI Phylogenetic Analysis of Novel G12 Rotaviruses in the United States: A
Molecular Search for the Origin of a New Strain
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE rotavirus; classification; evolution; genetic shift; vaccine
ID POLYMERASE CHAIN-REACTION; GROUP-A ROTAVIRUSES; GENETIC-HETEROGENEITY;
VP6 GENES; CHILDREN; DIARRHEA; EMERGENCE; SEROTYPE; INDIA;
IDENTIFICATION
AB Rotavirus serotype G12 was initially identified in the Philippines in 1987 and was not described again until it reemerged more than 13 years later. G12 strains were first detected in the United States in 2002 and have recently assumed a worldwide distribution. The high similarity between the sequence of the major outer capsid VP7 gene of human G12 strains and the single porcine G12 isolate raised the prospect that human strains may have arisen through reassortment with porcine strains or, alternatively, that the porcine strain originally came from humans. We sequenced portions of the remaining 10 segments of two human G12 strains (G12P[8] and G12P[61]) and a currently circulating common strain (GlP[8]) identified during the 2005-2006 surveillance season and compared the sequences with those of strains available through GenBank. By comparison, the three strains were all Wa-like and not porcine-like. A newly outlined classification system proposed genotypes for each gene segment based on nucleotide similarity. Using this approach, gene segments VP1-3, VP6 and NSP1-5 grouped within the same genotype, indicating that the three strains analyzed were closely related. These results suggest that the novel G12P[8] strain could have been formed by the solitary introduction of a VP7 gene into a globally common rotavirus strain, GlP[8]. Classifying rotavirus strains based only on VP7 (G) and VP4 (P) genotype potentially underestimates diversity and sequence analysis of the other segments is required to assess the complete genetic relationships between strains. J. Med. Virol. 81:736-746, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Freeman, M. M.; Kerin, T.; Hull, J.; Teel, E.; Esona, M.; Gentsch, J. R.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA USA.
[Parashar, U.] Ctr Dis Control & Prevent, Epidemiol Branch, Atlanta, GA USA.
[Glass, R. I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Freeman, MM (reprint author), 1600 Clifton Rd NE,Mail Stop C-03, Atlanta, GA 30333 USA.
EM mmfreeman@cdc.gov
FU Atlanta Research and Education Foundation
FX Grant sponsor: Atlanta Research and Education Foundation (to T. Kerin
and E. Teel).
NR 53
TC 28
Z9 28
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD APR
PY 2009
VL 81
IS 4
BP 736
EP 746
DI 10.1002/jmv.21446
PG 11
WC Virology
SC Virology
GA 413AS
UT WOS:000263765900023
PM 19235867
ER
PT J
AU Chang, MH
Plata, C
Zandi-Nejad, K
Sindic, A
Sussman, CR
Mercado, A
Broumand, V
Raghuram, V
Mount, DB
Romero, MF
AF Chang, Min-Hwang
Plata, Consuelo
Zandi-Nejad, Kambiz
Sindic, Aleksandra
Sussman, Caroline R.
Mercado, Adriana
Broumand, Vadjista
Raghuram, Viswanathan
Mount, David B.
Romero, Michael F.
TI Slc26a9-Anion Exchanger, Channel and Na+ Transporter
SO JOURNAL OF MEMBRANE BIOLOGY
LA English
DT Article
DE Intracellular pH; Cl-; Na+; HCO3-; Xenopus oocyte expression; Epithelial
localization
ID CONGENITAL CHLORIDE DIARRHEA; ELECTROGENIC NA+-HCO3-COTRANSPORTER;
DYSPLASIA SULFATE TRANSPORTER; PUTATIVE ANION TRANSPORTER; DEPENDENT
HCO3-TRANSPORT; DIASTROPHIC DYSPLASIA; CL-/HCO3-EXCHANGE;
CYSTIC-FIBROSIS; RAT-KIDNEY; MOLECULAR CHARACTERIZATION
AB The SLC26 gene family encodes anion transporters with diverse functional attributes: (a) anion exchanger, (b) anion sensor, and (c) anion conductance (likely channel). We have cloned and studied Slc26a9, a paralogue expressed mostly in lung and stomach. Immunohistochemistry shows that Slc26a9 is present at apical and intracellular membranes of lung and stomach epithelia. Using expression in Xenopus laevis oocytes and ion-sensitive microelectrodes, we discovered that Slc26a9 has a novel function not found in any other Slc26 proteins: cation coupling. Intracellular pH and voltage measurements show that Slc26a9 is a nCl(-)-HCO (3) (-) exchanger, suggesting roles in gastric HCl secretion or pulmonary HCO (3) (-) secretion; Na+ electrodes and uptakes reveal that Slc26a9 has a cation dependence. Single-channel measurements indicate that Slc26a9 displays discrete open and closed states. These experiments show that Slc26a9 has three discrete physiological modes: nCl(-)-HCO (3) (-) exchanger, Cl- channel, and Na+-anion cotransporter. Thus, the Slc26a9 transporter channel is uniquely suited for dynamic and tissue-specific physiology or regulation in epithelial tissues.
C1 [Chang, Min-Hwang; Sindic, Aleksandra; Sussman, Caroline R.; Romero, Michael F.] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA.
[Chang, Min-Hwang; Plata, Consuelo; Sindic, Aleksandra; Sussman, Caroline R.; Romero, Michael F.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
[Plata, Consuelo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 14000, DF, Mexico.
[Zandi-Nejad, Kambiz; Mercado, Adriana; Broumand, Vadjista; Mount, David B.] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA.
[Sindic, Aleksandra] Univ Zagreb, Croatian Inst Brain Res, Sch Med, Zagreb 41000, Croatia.
[Raghuram, Viswanathan] NHLBI, NIH, Bethesda, MD 20892 USA.
[Mount, David B.] VA Boston Healthcare Syst, Div Renal, Boston, MA 02132 USA.
RP Romero, MF (reprint author), Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, 200 1st St SW, Rochester, MN 55905 USA.
EM romero.michael@mayo.edu
RI Plata, Consuelo/M-4482-2015
OI Plata, Consuelo/0000-0001-9340-8950
FU NIH [DK056218, DK060845, EY017732, DK038226, DK070756, DK57708,
F32-DK65482]; Veterans Administration; Wadsworth Foundation; American
Heart Association; Cystic Fibrosis Foundation [RO-MERO-06GO,
SINDIC-06F0]
FX We thank N. Angle, G. Babcock, L. Song, Q. Xie, R. Welch, and M. Sanders
for excellent technical support. We thank Dr. S. Muallem for the Slc26a7
cDNA. We also thank Drs. S. W. Jones and C. Objero-Paz for discussions
and initial patch experiments. This work was supported by NIH Grants
DK056218, DK060845, and EY017732 (M. F. R.); DK038226, DK070756, and
DK57708 (D. B. M.); and F32-DK65482 (V.B.). Other funding includes an
Advanced Career Development Award from the Veterans Administration
(DBM); the Wadsworth Foundation & American Heart Association (AHA; C. R.
S.); a postdoctoral fellowship from the AHA (M.-H.C. and K.Z.); and the
Cystic Fibrosis Foundation (RO-MERO-06GO and SINDIC-06F0).
NR 58
TC 35
Z9 37
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2631
J9 J MEMBRANE BIOL
JI J. Membr. Biol.
PD APR
PY 2009
VL 228
IS 3
BP 125
EP 140
DI 10.1007/s00232-009-9165-5
PG 16
WC Biochemistry & Molecular Biology; Cell Biology; Physiology
SC Biochemistry & Molecular Biology; Cell Biology; Physiology
GA 445GT
UT WOS:000266039200001
PM 19365592
ER
PT J
AU Lee, YJ
Castri, P
Bembry, J
Maric, D
Auh, S
Hallenbeck, JM
AF Lee, Yang -ja
Castri, Paola
Bembry, Joliet
Maric, Dragan
Auh, Sungyoung
Hallenbeck, John M.
TI SUMOylation participates in induction of ischemic tolerance
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE cortical neurons; ischemic preconditioning; neuroprotection;
post-translational modification; SHSY5Y; SUMO
ID FOCAL CEREBRAL-ISCHEMIA; PROTEIN SUMOYLATION; HIBERNATION; SUMO;
NEUROPROTECTION; HYPOXIA; HYPOTHERMIA; BRAIN; MODEL
AB Ground squirrels in hibernation torpor have been shown to have striking increases in global SUMOylation on tissue immunoblots. Here, we find evidence that global SUMOylation is also involved in ischemic tolerance in primary cortical neuronal cultures (from rats and mice) and SHSY5Y human neuroblastoma cells. Cultured cortical neurons preconditioned by sublethal oxygen/glucose deprivation (OGD) were less vulnerable to severe OGD than non-preconditioned neurons. Preconditioned neurons maintained elevated SUMO-1 conjugation levels (and, to a lesser extent those of SUMO-2/3) on western blots in contrast to non-preconditioned cells. Further, cortical neurons and SHSY5Y cells in which transfected SUMO-1 or SUMO-2 were over-expressed showed increased survival after severe OGD. In contrast, cell cultures subjected to depletion of endogenous SUMO-1 protein by RNAi had reduced survival after exposure to this form of in vitro ischemia and an attenuated protective response to preconditioning. These findings suggest that maintenance of a globally elevated SUMO-1 (and maybe SUMO-2/3) conjugation level as revealed by immunoblot assays is a component of ischemic tolerance.
C1 [Lee, Yang -ja; Castri, Paola; Bembry, Joliet; Hallenbeck, John M.] NINDS, Stroke Branch, NIH, Bethesda, MD 20892 USA.
[Maric, Dragan] NINDS, Neurophysiol Lab, NIH, Bethesda, MD 20892 USA.
[Auh, Sungyoung] NINDS, Off Clin Director, NIH, Bethesda, MD 20892 USA.
RP Hallenbeck, JM (reprint author), NINDS, Stroke Branch, NIH, Bldg 49,Rm2A10,MSC 4476,49 Convent Dr, Bethesda, MD 20892 USA.
EM hallenbj@ninds.nih.gov
FU Intramural Research Program of the NINDS/NIH
FX The authors thank Dace Klimanis for technical assistance and Maria Spatz
for valuable suggestions.
NR 27
TC 56
Z9 56
U1 1
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD APR
PY 2009
VL 109
IS 1
BP 257
EP 267
DI 10.1111/j.1471-4159.2009.05957.x
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 416RH
UT WOS:000264022700024
PM 19200349
ER
PT J
AU Gleichmann, M
Collis, LP
Smith, PJS
Mattson, MP
AF Gleichmann, Marc
Collis, Leon P.
Smith, Peter J. S.
Mattson, Mark P.
TI Simultaneous single neuron recording of O-2 consumption, [Ca2+](i) and
mitochondrial membrane potential in glutamate toxicity
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE excitotoxicity; glutamate; oxygen consumption
ID SPARE RESPIRATORY CAPACITY; CEREBELLAR GRANULE NEURONS; PANCREATIC
BETA-CELLS; HIPPOCAMPAL-NEURONS; OXIDATIVE STRESS; NEURODEGENERATIVE
DISORDERS; OXYGEN-CONSUMPTION; EXCITOTOXICITY; EXPRESSION;
MICROELECTRODE
AB In order to determine the sequence of cellular processes in glutamate toxicity, we simultaneously recorded O-2 consumption, cytosolic Ca2+ concentration ([Ca2+](i)), and mitochondrial membrane potential (m Delta psi) in single cortical neurons. Oxygen consumption was measured using an amperometric self-referencing platinum electrode adjacent to neurons in which [Ca2+](i) and m Delta psi were monitored with Fluo-4 and TMRE+, respectively, using a spinning disk laser confocal microscope. Excitotoxic doses of glutamate caused an elevation of [Ca2+](i) followed seconds afterwards by an increase in O-2 consumption which reached a maximum level within 1-5 min. A modest increase in m Delta psi occurred during this time period, and then, shortly before maximal O-2 consumption was reached, the m Delta psi, as indicated by TMRE+ fluorescence, dissipated. Maximal O-2 consumption lasted up to 5 min and then declined together with m Delta psi and ATP levels, while [Ca2+](i) further increased. m Delta psi and [Ca2+](i) returned to baseline levels when neurons were treated with an NMDA receptor antagonist shortly after the [Ca2+](i) increased. Our unprecedented spatial and time resolution revealed that this sequence of events is identical in all neurons, albeit with considerable variability in magnitude and kinetics of changes in O-2 consumption, [Ca2+](i), and m Delta psi. The data obtained using this new method are consistent with a model where Ca2+ influx causes ATP depletion, despite maximal mitochondrial respiration, minutes after glutamate receptor activation.
C1 [Gleichmann, Marc; Mattson, Mark P.] NIA, Neurosci Lab, Intramural Res Program, Biomed Res Ctr, Baltimore, MD 21224 USA.
[Collis, Leon P.; Smith, Peter J. S.] BioCurrents Res Ctr, Marine Biol Lab, Woods Hole, MA USA.
RP Mattson, MP (reprint author), 251 Bayview Blvd,5th Floor,Suite 100, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Mattson, Mark/F-6038-2012
FU National Institute on Aging; NIH; NCCR [P41 RR001395, NCRR P41
RR0013095]
FX This research was supported in part by the Intramural Research Program
of the National Institute on Aging, NIH and NCCR (P41 RR001395Grant NCRR
P41 RR0013095; PJSS).
NR 27
TC 24
Z9 24
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD APR
PY 2009
VL 109
IS 2
BP 644
EP 655
DI 10.1111/j.1471-4159.2009.05997.x
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 421FX
UT WOS:000264345900033
PM 19226367
ER
PT J
AU McMahon, DBT
Olson, CR
AF McMahon, David B. T.
Olson, Carl R.
TI Linearly Additive Shape and Color Signals in Monkey Inferotemporal
Cortex
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
ID TEMPORAL CORTICAL-NEURONS; VISUAL-SEARCH; FEATURE-INTEGRATION; OBJECT
RECOGNITION; NEURAL MECHANISMS; MACAQUE MONKEY; ATTENTION; BINDING;
HYPOTHESIS; SYNCHRONY
AB McMahon DBT, Olson CR. Linearly additive shape and color signals in monkey inferotemporal cortex. J Neurophysiol 101: 1867-1875, 2009. First published January 14, 2009; doi: 10.1152/jn.90650.2008. How does the brain represent a red circle? One possibility is that there is a specialized and possibly time-consuming process whereby the attributes of shape and color, carried by separate populations of neurons in low-order visual cortex, are bound together into a unitary neural representation. Another possibility is that neurons in high-order visual cortex are selective, by virtue of their bottom-up input from low-order visual areas, for particular conjunctions of shape and color. A third possibility is that they simply sum shape and color signals linearly. We tested these ideas by measuring the responses of inferotemporal cortex neurons to sets of stimuli in which two attributes-shape and color-varied independently. We find that a few neurons exhibit conjunction selectivity but that in most neurons the influences of shape and color sum linearly. Contrary to the idea of conjunction coding, few neurons respond selectively to a particular combination of shape and color. Contrary to the idea that binding requires time, conjunction signals, when present, occur as early as feature signals. We argue that neither conjunction selectivity nor a specialized feature binding process is necessary for the effective representation of shapecolor combinations.
C1 Univ Pittsburgh, Mellon Inst, Ctr Neural Basis Cognit, Pittsburgh, PA USA.
Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA.
RP McMahon, DBT (reprint author), NIMH, Neuropsychol Lab, NIH, 49 Convent Dr,Room B2-J45, Bethesda, MD 20892 USA.
EM mcmahond@mail.nih.gov
FU National Institutes of Health [EY-018620, F31 NS-043876]; Pennsylvania
Department of Health through the Commonwealth Universal Research
Enhancement Program; National Center for Research Resources
[P41RR-03631]
FX This research was supported by National Institutes of Health Grants
EY-018620 to C. R. Olson and F31 NS-043876 to D. B. T. McMahon and the
Pennsylvania Department of Health through the Commonwealth Universal
Research Enhancement Program. The collection of magnetic resonance
images was supported by National Center for Research Resources Grant
P41RR-03631.
NR 39
TC 11
Z9 11
U1 2
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD APR
PY 2009
VL 101
IS 4
BP 1867
EP 1875
DI 10.1152/jn.90650.2008
PG 9
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 422ZA
UT WOS:000264465000018
PM 19144745
ER
PT J
AU Rubin, JE
Shevtsova, NA
Ermentrout, GB
Smith, JC
Rybak, IA
AF Rubin, Jonathan E.
Shevtsova, Natalia A.
Ermentrout, G. Bard
Smith, Jeffrey C.
Rybak, Ilya A.
TI Multiple Rhythmic States in a Model of the Respiratory Central Pattern
Generator
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
ID PRE-BOTZINGER COMPLEX; NEURONAL COMPETITION MODELS; PERSISTENT SODIUM
CURRENT; UPPER AIRWAY-RESISTANCE; EXPIRATORY NEURONS; BRAIN-STEM;
IN-VITRO; PREBOTZINGER COMPLEX; GLUTAMATE RECEPTORS; FUNCTIONAL
ASSOCIATIONS
AB Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA. Multiple rhythmic states in a model of the respiratory central pattern generator. J Neurophysiol 101: 2146-2165, 2009. First published February 4, 2009; doi:10.1152/jn.90958.2008. The three-phase respiratory pattern observed during normal breathing changes with alterations in metabolic or physiological conditions. A recent study using in situ perfused rat brain preparations demonstrated a reorganization of the respiratory pattern with sequential reduction of the brain stem respiratory network. Specifically, with removal of the pons, the normal three-phase pattern transformed to a two-phase inspiratory-expiratory pattern and, with more caudal transections, to one-phase, intrinsically generated inspiratory oscillations. A minimal neural network proposed to reproduce these transformations includes 1) a ringlike mutually inhibitory network composed of the postinspiratory, augmenting expiratory, and early-inspiratory neurons and 2) an excitatory preinspiratory neuron, with persistent sodium current (I(NaP))-dependent intrinsic bursting properties, that dynamically participates in the expiratory-inspiratory phase transition and inspiratory phase generation. We used activity-based single-neuron models and applied numerical simulations, bifurcation methods, and fast-slow decomposition to describe the behavior of this network in the functional states corresponding to the three-, two-, and one-phase oscillatory regimes, as well as to analyze the transitions between states and between respiratory phases within each state. We demonstrate that, although I(NaP) is not necessary for the generation of three- and two-phase oscillations, it contributes to control of the oscillation period in each state. We also show that the transitions between states can be produced by progressive changes of drives to particular neurons and proceed through intermediate regimes, featuring high-amplitude late-expiratory and biphasic-expiratory activities or ectopic burst generation. Our results provide important insights for understanding the state-dependent mechanisms for respiratory rhythm generation and control.
C1 [Rubin, Jonathan E.; Ermentrout, G. Bard] Univ Pittsburgh, Dept Math, Pittsburgh, PA 15260 USA.
[Shevtsova, Natalia A.; Rybak, Ilya A.] Drexel Univ, Dept Neurobiol & Anat, Coll Med, Philadelphia, PA 19104 USA.
[Smith, Jeffrey C.] Natl Inst Neurol Disorders & Stroke, Cellular & Syst Neurobiol Sect, Porter Neurosci Res Ctr, NIH, Bethesda, MD USA.
[Shevtsova, Natalia A.] S Fed Univ, AB Kogan Res Inst Neurocybernet, Rostov Na Donu, Russia.
RP Rubin, JE (reprint author), Univ Pittsburgh, Dept Math, Pittsburgh, PA 15260 USA.
EM rubin@math.pitt.edu
FU National Science Foundation (NSF) Division of Mathematical Sciences;
NSF/National Institutes of Health Collaborative Research in
Computational Neuroscience Program; National Institute of Neurological
Disorders and Stroke (NINDS) [R01 NS-057815]; NINDS Intramural Research
Program
FX This study was supported by National Science Foundation (NSF) Division
of Mathematical Sciences grants to J. E. Rubin and G. B. Ermentrout, the
NSF/National Institutes of Health Collaborative Research in
Computational Neuroscience Program, National Institute of Neurological
Disorders and Stroke (NINDS) Grant R01 NS-057815 to I. A. Rybak, N. A.
Shevtsova, and J. C. Smith, and by the NINDS Intramural Research Program
to J. C. Smith.
NR 72
TC 51
Z9 53
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD APR
PY 2009
VL 101
IS 4
BP 2146
EP 2165
DI 10.1152/jn.90958.2008
PG 20
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 422ZA
UT WOS:000264465000041
PM 19193773
ER
PT J
AU Zhang, J
Diamond, JS
AF Zhang, Jun
Diamond, Jeffrey S.
TI Subunit- and Pathway-Specific Localization of NMDA Receptors and
Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID LONG-TERM POTENTIATION; NR1 SPLICE VARIANTS; CEREBELLAR GRANULE NEURONS;
IMMUNOCYTOCHEMICAL LOCALIZATION; SYNAPTIC LOCALIZATION; HIPPOCAMPAL
SYNAPSES; GUANYLATE KINASES; MAMMALIAN RETINA; CAT RETINA; MOLECULAR
CHARACTERIZATION
AB Retinal ganglion cells (RGCs) receive excitatory glutamatergic input from ON and OFF bipolar cells in distinct sublaminae of the inner plexiform layer (IPL). AMPA and NMDA receptors (AMPARs and NMDARs) mediate excitatory inputs in both synaptic layers, but specific roles for NMDARs at RGC synapses remain unclear. NMDARs comprise NR1 and NR2 subunits and are anchored by membrane-associated guanylate kinases (MAGUKs), but it is unknown whether particular NR2 subunits associate preferentially with particular NR1 splice variants and MAGUKs. Here, we used postembedding immunogold electron microscopy techniques to examine the subsynaptic localization of NMDAR subunits and MAGUKs at ON and OFF synapses onto rat RGCs. We found that the NR2A subunit, the NR1C2' splice variant, and MAGUKs PSD-95 and PSD-93 are localized to the postsynaptic density (PSD), preferentially at OFF synapses, whereas the NR2B subunit, the NR1C2 splice variant, and the MAGUK SAP102 are localized perisynaptically, with NR2B exhibiting a preference for ON synapses. Consistent with these anatomical data, spontaneous EPSCs (sEPSCs) recorded from OFF cells exhibited an NMDAR component that was insensitive to the NR2B antagonist Ro 25-6981. In ON cells, sEPSCs expressed an NMDAR component, partially sensitive to Ro 25-6981, only when glutamate transport was inhibited, indicating perisynaptic expression of NR2B NMDARs. These results provide the first evidence for preferential association of particular NR1 splice variants, NR2 subunits, and MAGUKs at central synapses and suggest that different NMDAR subtypes may play specific roles at functionally distinct synapses in the retinal circuitry.
C1 [Zhang, Jun; Diamond, Jeffrey S.] NINDS, Synapt Physiol Sect, NIH, Bethesda, MD 20892 USA.
RP Diamond, JS (reprint author), NINDS, Synapt Physiol Sect, NIH, 35 Convent Dr,Bldg 35,Room 3C-1000, Bethesda, MD 20892 USA.
EM diamondj@ninds.nih.gov
RI Zhang, Jun/K-2424-2012; Diamond, Jeffrey/C-1835-2015
OI Diamond, Jeffrey/0000-0002-1770-2629
FU National Institute of Neurological Disorders and Stroke (NINDS)
FX This work was supported by the National Institute of Neurological
Disorders and Stroke (NINDS) Intramural Research Program. We thank Drs.
Pierre Brown and Charles Gerfen for performing CTB injections; Drs.
Brian Andrews, Christine Winters, Natalia Pivovarova, and Christine
Brantner for help with freeze substitution; the NINDS LM and EM
facilities for microscopy assistance; Drs. William Grimes and Annalisa
Scimemi for experimental and analytical advice and assistance; and Dr.
Christopher Thomas for comments on this manuscript.
NR 84
TC 47
Z9 47
U1 0
U2 7
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 1
PY 2009
VL 29
IS 13
BP 4274
EP 4286
DI 10.1523/JNEUROSCI.5602-08.2009
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA 427GJ
UT WOS:000264767500030
PM 19339621
ER
PT J
AU Miki, K
Ishibashi, S
Sun, LY
Xu, HY
Ohashi, W
Kuroiwa, T
Mizusawa, H
AF Miki, Kazunori
Ishibashi, Satoru
Sun, Liyuan
Xu, Haiyan
Ohashi, Wataru
Kuroiwa, Toshihiko
Mizusawa, Hidehiro
TI Intensity of Chronic Cerebral Hypoperfusion Determines White/Gray Matter
Injury and Cognitive/Motor Dysfunction in Mice
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE cerebral blood flow; ischemia; cognitive impairment; mouse; white matter
ID GLOBAL-ISCHEMIA; MOUSE MODEL; BLOOD-FLOW; FOREBRAIN ISCHEMIA; MONGOLIAN
GERBILS; GLIAL ACTIVATION; LEARNING DEFICIT; WISTAR RATS; IMPAIRMENT;
BRAIN
AB We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57BI/6 male (n = 48) mice were subjected to bilateral common carotid artery stenosis with external microcoils (inner diameters: 0.16 mm, left; 0.18 mm, right). Mice were categorized according to left-side cerebral blood flow (CBF) value on day 6 into those with severe cerebral hypoperfusion (SCH; n = 16, < 30% of preoperative CBF baseline value) or moderate cerebral hypoperfusion (MCH; n = 21, 30-50% of preoperative value). Another 15 mice were sham operated. Neurological dysfunction was evaluated by Morris water maze, rotating rod, and open field tests. Histopathological examination was performed on day 35 after surgery. MCH animals showed persistent hyperlocomotion with reduced anxiety and spatial reference memory dysfunction. Rarefaction and small necrotic lesions were predominantly confined to the WM, with reactive astrocytosis, microglial infiltration, axonal loss, and myelin disruption, and these changes were dominant on the left side. SCH animals had persistent hyperlocomotion and motor dysfunction, and their ischemic lesions extended from the WM to the hippocampus and cortex. In MCH animals, myelin basic protein and neurofilament fiber densities in the WM were correlated with the time spent in the correct area in the water maze probe trials. Our MCH mouse model with the development of several types of neurological dysfunction with high reproducibility would be useful for investigating the pathomechanisms of WM injury in human SIVD. (C) 2008 Wiley-Liss, Inc.
C1 [Mizusawa, Hidehiro] Tokyo Med & Dent Univ, Dept Neurol & Neurol Sci, Grad Sch Med, Bunkyo Ku, Tokyo 1138510, Japan.
[Ishibashi, Satoru] Natl Inst Neurol Disorders & Stroke, Stroke Branch, NIH, Bethesda, MD USA.
[Ohashi, Wataru] Tokyo Med & Dent Univ, Dept Bioinformat, Grad Sch Med, Tokyo 1138510, Japan.
[Kuroiwa, Toshihiko] Namegata Dist Gen Hosp, Clin Lab, Ibaraki, Japan.
[Kuroiwa, Toshihiko] Tokyo Med & Dent Univ, Dept Pathophysiol, Med Res Inst, Tokyo 1138510, Japan.
RP Mizusawa, H (reprint author), Tokyo Med & Dent Univ, Dept Neurol & Neurol Sci, Grad Sch Med, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM h-mizusawa.nuro@tmd.ac.jp
NR 44
TC 38
Z9 38
U1 0
U2 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0360-4012
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD APR
PY 2009
VL 87
IS 5
BP 1270
EP 1281
DI 10.1002/jnr.21925
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 416DF
UT WOS:000263984700023
PM 18951530
ER
PT J
AU Liu, Y
Rossin, R
Abendschein, D
Zheng, J
McCommis, K
Woodard, GE
Woodard, P
Welch, MJ
AF Liu, Y.
Rossin, R.
Abendschein, D.
Zheng, J.
McCommis, K.
Woodard, G. E.
Woodard, P.
Welch, M. J.
TI Molecular Imaging of Atherosclerotic Plaque with 64-Cu- Labeled
Natriuretic Peptide and Positron Emission Tomography.
SO JOURNAL OF NUCLEAR MEDICINE
LA English
DT Meeting Abstract
CT Multimodality Cardiovascular Imaging Symposium 2009
CY APR 30-MAY 01, 2009
CL Washington, DC
C1 [Liu, Y.; Rossin, R.; Zheng, J.; McCommis, K.; Woodard, P.; Welch, M. J.] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA.
[Abendschein, D.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
[Woodard, G. E.] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU SOC NUCLEAR MEDICINE INC
PI RESTON
PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA
SN 0161-5505
J9 J NUCL MED
JI J. Nucl. Med.
PD APR 1
PY 2009
VL 50
IS 4
MA 5
BP 658
EP 658
PG 1
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 529AD
UT WOS:000272487200031
ER
PT J
AU Heroux, J
Gharib, AM
Danthi, NS
Cecchini, S
Ohavon, J
Pettigrew, RI
AF Heroux, J.
Gharib, A. M.
Danthi, N. S.
Cecchini, S.
Ohavon, J.
Pettigrew, R. I.
TI High Affinity AVB3 Targeted Optical Probe in Early Atherosclerosis
Detection.
SO JOURNAL OF NUCLEAR MEDICINE
LA English
DT Meeting Abstract
CT Multimodality Cardiovascular Imaging Symposium 2009
CY APR 30-MAY 01, 2009
CL Washington, DC
C1 [Heroux, J.; Gharib, A. M.] NIDDK, NIH, Bethesda, MD USA.
[Danthi, N. S.; Cecchini, S.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Ohavon, J.] NHLBI, NIH, La Tronche, France.
[Pettigrew, R. I.] NIBIB, NIH, Bethesda, MD USA.
RI Danthi, Simhan/B-7639-2014; Gharib, Ahmed/O-2629-2016
OI Gharib, Ahmed/0000-0002-2476-481X
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SOC NUCLEAR MEDICINE INC
PI RESTON
PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA
SN 0161-5505
J9 J NUCL MED
JI J. Nucl. Med.
PD APR 1
PY 2009
VL 50
IS 4
MA 12
BP 660
EP 660
PG 1
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 529AD
UT WOS:000272487200038
ER
PT J
AU Cheal, SM
Dulcey, A
Regino, C
Shenoy, N
Shi, ZD
Sulima, A
Vasalatiy, O
Wu, H
Xu, B
Barbacow, K
Cofiell, S
Wilson, CM
Griffiths, GL
AF Cheal, S. M.
Dulcey, A.
Regino, C.
Shenoy, N.
Shi, Z-D.
Sulima, A.
Vasalatiy, O.
Wu, H.
Xu, B.
Barbacow, K.
Cofiell, S.
Wilson, C. M.
Griffiths, G. L.
TI The Imaging Probe Development Center-A Core Synthetic Facility Dedicated
to Production of Known and Novel Molecular Imaging Probes.
SO JOURNAL OF NUCLEAR MEDICINE
LA English
DT Meeting Abstract
CT Multimodality Cardiovascular Imaging Symposium 2009
CY APR 30-MAY 01, 2009
CL Washington, DC
C1 [Cheal, S. M.; Dulcey, A.; Regino, C.; Shenoy, N.; Shi, Z-D.; Sulima, A.; Vasalatiy, O.; Wu, H.; Xu, B.; Barbacow, K.; Cofiell, S.; Wilson, C. M.; Griffiths, G. L.] NHLBI, NIH, Bethesda, MD 20892 USA.
RI Shenoy, Nalini/O-2132-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SOC NUCLEAR MEDICINE INC
PI RESTON
PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA
SN 0161-5505
J9 J NUCL MED
JI J. Nucl. Med.
PD APR 1
PY 2009
VL 50
IS 4
MA 17
BP 661
EP 662
PG 2
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 529AD
UT WOS:000272487200043
ER
PT J
AU Lovestone, S
Thambisetty, M
AF Lovestone, S.
Thambisetty, M.
TI Biomarkers for Alzheimer's disease trials - biomarkers for what? A
discussion paper
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Editorial Material
C1 [Lovestone, S.] Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, Inst Psychiat, London SE5 8AF, England.
[Thambisetty, M.] NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA.
RP Lovestone, S (reprint author), Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, Inst Psychiat, Crespigny Pk, London SE5 8AF, England.
EM s.lovestone@iop.kcl.ac.uk; thambisettym@mail-nih.gov
RI Lovestone, Simon/E-8725-2010
NR 5
TC 11
Z9 11
U1 1
U2 1
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD APR
PY 2009
VL 13
IS 4
BP 334
EP 336
DI 10.1007/s12603-009-0033-x
PG 3
WC Geriatrics & Gerontology; Nutrition & Dietetics
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 443WM
UT WOS:000265941500009
PM 19300870
ER
PT J
AU Leibel, N
Shen, W
Mao, X
Punyanitya, M
Gallagher, D
Horlick, M
Shungu, DC
Oberfield, SE
AF Leibel, Natasha
Shen, Wei
Mao, Xiangling
Punyanitya, Mark
Gallagher, Dympna
Horlick, Mary
Shungu, Dikoma C.
Oberfield, Sharon E.
TI Body Composition in Premature Adrenarche by Structural MRI, H-1 MRS and
DXA
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE premature adrenarche; proton magnetic resonance spectroscopy;
intramyocellular lipid; metabolic syndrome; diabetes mellitus; body
composition
ID MAGNETIC-RESONANCE-SPECTROSCOPY; POLYCYSTIC-OVARY-SYNDROME; INSULIN
SENSITIVITY; TRIGLYCERIDE CONTENT; GLUCOSE-TOLERANCE; PREPUBERTAL GIRLS;
BINDING PROTEIN-1; HISPANIC GIRLS; IGF-I; RESISTANCE
AB Background: Premature adrenarche (PA) is recognized to be a possible precursor of polycystic ovarian syndrome, type 2 diabetes mellitus and cardiovascular disease. Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease.
Aim: To determine whether prepubertal girls with PA have altered visceral adiposity and/or increased muscle lipid content compared to prepubertal girls without PA using proton magnetic resonance imaging (MRI) and spectroscopy (H-1 MRS).
Patients and Methods: We performed total body dual energy X-ray absorptiometry (DXA) scans, MRI of the trunk, and MRS of the tibialis anterior muscle in the right calf on six girls with PA and eight prepubertal controls.
Results: Amount of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and VAT to SAT ratio did not differ significantly between the PA and control girls. Those with PA, however, had significantly greater IMCL than controls (p = 0.004).
Conclusions: This study adds further evidence that PA is not a benign condition, and future studies investigating early intervention with dietary and exercise counseling may help diminish potential risk for diabetes mellitus and/or cardiovascular disease.
C1 [Oberfield, Sharon E.] New York Presbyterian Hosp, Dept Pediat, Div Pediat Endocrinol, New York, NY 10032 USA.
[Shen, Wei; Punyanitya, Mark; Gallagher, Dympna] Columbia Univ, St Lukes Hosp, New York Obes Res Ctr, New York, NY USA.
[Shen, Wei; Punyanitya, Mark; Gallagher, Dympna] Columbia Univ, Inst Human Nutr, New York, NY 10032 USA.
[Mao, Xiangling; Shungu, Dikoma C.] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY 10021 USA.
[Horlick, Mary] NIDDK, NIH, Bethesda, MD USA.
RP Oberfield, SE (reprint author), New York Presbyterian Hosp, Dept Pediat, Div Pediat Endocrinol, 630 West 168h St,PH-5E-522, New York, NY 10032 USA.
EM seo8@columbia.edu
OI Gallagher, Dympna/0000-0003-1769-9754; Punyanitya,
Mark/0000-0003-3678-2262; Shungu, Dikoma/0000-0001-9452-2245
FU Genentech; Pfizer
FX Funding for this study was provided by unrestricted grants from
Genentech and Pfizer. The authors declare no conflict of interest.
NR 19
TC 1
Z9 1
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD APR
PY 2009
VL 22
IS 4
BP 301
EP 307
PG 7
WC Endocrinology & Metabolism; Pediatrics
SC Endocrinology & Metabolism; Pediatrics
GA 450HI
UT WOS:000266391200004
PM 19554803
ER
PT J
AU Capitini, CM
Cooper, LJN
Egeler, RM
Handgretinger, R
Locatelli, F
Sondel, PM
Mackall, CL
AF Capitini, Christian M.
Cooper, Laurence J. N.
Egeler, R. Maarten
Handgretinger, Rupert
Locatelli, Franco
Sondel, Paul M.
Mackall, Crystal L.
TI Highlights of the First International "Immunotherapy in Pediatric
Oncology: Progress and Challenges" Meeting
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Editorial Material
DE immunotherapy; cell surface receptors; T cells; innate immunity;
graft-versus-leukemia
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; CD8(+) T-CELLS;
OSTEOSARCOMA LUNG METASTASES; ANTIGEN-PRESENTING CELLS; PHASE-I TRIAL;
GENETIC-MODIFICATION; ADOPTIVE TRANSFER; FAS PATHWAY; NEUROBLASTOMA
AB The first annual conference on immunotherapy in pediatric oncology was field in Bethesda, MD, from September 9 to 10, 2008 to discuss the state-of-the-art of immunotherapeutic strategies currently being explored in pediatric oncology. Major topics included targeting cell surface receptors, understanding and improving T-cell-based therapies, augmenting innate immune strategies, and enhancing graft-versus-leukemia for pediatric malignancies. As can be seen in the summaries of the individual presentations, significant progress has been made in developing preclinical models of pediatric tumors and a variety of novel immunobiologic therapies are approaching, or already in, the clinic. Although there is much excitement about the potential utility of these agents, a great deal of challenges lie ahead in improving the efficacy of each of these modalities and getting them to patients in a timely fashion. The resulting discussions will hopefully lead to new collaborations and insight for further translational and clinical studies.
C1 [Capitini, Christian M.; Mackall, Crystal L.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Cooper, Laurence J. N.] Univ Texas MD Anderson Canc Ctr, Dept Pediat, Houston, TX 77030 USA.
[Sondel, Paul M.] Univ Wisconsin, Dept Pediat, Madison, WI USA.
[Sondel, Paul M.] Univ Wisconsin, Dept Human Oncol, Madison, WI USA.
[Egeler, R. Maarten] Leiden Univ, Dept Pediat, Med Ctr, Leiden, Netherlands.
[Handgretinger, Rupert] Univ Tubingen, Childrens Univ Hosp, Dept Pediat Hematol Oncol, Tubingen, Germany.
[Locatelli, Franco] Univ Pavia, Dept Pediat, I-27100 Pavia, Italy.
RP Capitini, CM (reprint author), NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, 10 Ctr Dr,Room 1W-5832, Bethesda, MD 20892 USA.
EM capitinic@mail.nih.gov
OI Capitini, Christian/0000-0002-2276-6731
FU Intramural NIH HHS [Z01 SC010281-10, Z01 SC010289-09, Z99 CA999999]
NR 54
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 227
EP 234
PG 8
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100001
PM 19346873
ER
PT J
AU Wayne, AS
Kreitman, RJ
Du, X
FitzGerald, DJ
Pastan, I
AF Wayne, Alan S.
Kreitman, Robert J.
Du, Xing
FitzGerald, David J.
Pastan, Ira
TI Immunotoxin-based Targeting of Acute Lymphoblastic Leukemia
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Meeting Abstract
C1 [Wayne, Alan S.] Pediat Oncol Grp, Hematol Dis Sect, Bethesda, MD USA.
[Kreitman, Robert J.] Clin Immunotherapy Sect, Mol Biol Lab, Bethesda, MD USA.
[Du, Xing; FitzGerald, David J.; Pastan, Ira] NCI, Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 236
EP 236
PG 1
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100006
ER
PT J
AU Cui, K
Guimond, M
Mackall, CL
AF Cui, Karen
Guimond, Martin
Mackall, Crystal L.
TI Exploiting and Inducing Changes in T-cell Homeostasis for Immune-based
Therapy of Pediatric Cancer
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Meeting Abstract
C1 [Cui, Karen; Guimond, Martin; Mackall, Crystal L.] NCI, Immunol Sect, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 237
EP 237
PG 1
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100011
ER
PT J
AU Jensen, MC
AF Jensen, Michael C.
TI Engineering Central Memory-derived T Cells for Adoptive Therapy of
Pediatric Malignancies
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Meeting Abstract
C1 [Jensen, Michael C.] City Hope NCI Designated Comprehens Canc Ctr, Canc Immunotherapeut Program, Duarte, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 237
EP 237
PG 1
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100010
ER
PT J
AU Barrett, J
AF Barrett, John
TI New Approaches for Separating GVH From GVL
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Meeting Abstract
C1 [Barrett, John] NHLBI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 243
EP 244
PG 2
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100028
ER
PT J
AU Fry, T
AF Fry, Terry
TI Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) as a Platform
for Cancer Immunotherapy
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Meeting Abstract
C1 [Fry, Terry] NCI, Childrens Natl Med Ctr, Pediat Oncol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD APR
PY 2009
VL 31
IS 4
BP 244
EP 244
PG 1
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 432TC
UT WOS:000265156100029
ER
PT J
AU Vohr, BR
Tyson, JE
Wright, LL
Perritt, RL
Li, L
Poole, WK
AF Vohr, Betty R.
Tyson, Jon E.
Wright, Linda L.
Perritt, Rebecca L.
Li, Lei
Poole, W. Kenneth
CA NICHD Neonatal Res Network
TI Maternal Age, Multiple Birth, and Extremely Low Birth Weight Infants
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID NEURODEVELOPMENTAL OUTCOMES; VITAL-STATISTICS; PREGNANCY; WOMEN; OLDER;
RISK
AB Objectives To compare the rates of adverse neurodevelopmental outcome or death at IS to 22 months among extremely low birth weight (ELBW) infants born to mothers >= 40 years to the corresponding rates among infants of younger mothers.
Study design Prospective evaluation of ELBW infants to quantify the relative risks of maternal age and multiple birth for death or adverse neurodevelopmental outcome.
Results The sample consisted of 14 671 live ELBW births divided into maternal age groups: <20, 20 to 29, 30 to 39, and >= 40 years. Of infants born to mothers >= 40 years, 20% were multiples. Mothers >= 40 years had high rates of obstetric interventions and medical morbidities compared with mothers <40 years. ELBW live births of mothers >= 40 years were 22% more likely to survive and bad a 13% decreased risk of neurodevelopmental impairment or death compared with mothers <20. Multiple birth, however, was associated with a 10% greater risk of neurodevelopmental impairment or death.
Conclusion Although mothers >= 40 years had high pregnancy-related morbidities, we found no overall increased risk of the composite outcome of death or NDI. Multiple birth, however, was a predictor of all adverse outcomes examined, regardless of maternal age. (J Pediatr 2009;154:498-503)
C1 [Vohr, Betty R.] Brown Univ, Warren Alpert Med Sch, Dept Pediat, Providence, RI 02912 USA.
[Tyson, Jon E.] Univ Texas Houston, Sch Med, Houston, TX USA.
[Wright, Linda L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
[Perritt, Rebecca L.; Li, Lei; Poole, W. Kenneth] RTI Int, Res Triangle Pk, NC USA.
RP Vohr, BR (reprint author), Brown Univ, Warren Alpert Med Sch, Dept Pediat, Providence, RI 02912 USA.
FU NCATS NIH HHS [UL1 TR000454]; NCRR NIH HHS [M01 RR001032, M01 RR002172,
M01 RR002635, M01 RR006022, M01 RR007122, M01 RR008084, M01 RR016587,
M01 RR1032, M01 RR16587, M01 RR2172, M01 RR2635, M01 RR30, M01 RR39, M01
RR44, M01 RR54, M01 RR59, M01 RR6022, M01 RR633, M01 RR64, M01 RR70, M01
RR7122, M01 RR750, M01 RR80, M01 RR8084, M01 RR997]; NICHD NIH HHS [U10
HD021364, U01 HD019897, U01 HD036790, U01 HD19897, U01 HD36790, U10
HD021373, U10 HD021385, U10 HD021397, U10 HD027851, U10 HD027853, U10
HD027856, U10 HD027871, U10 HD027880, U10 HD027904, U10 HD027904-19, U10
HD034167, U10 HD034216, U10 HD040461, U10 HD040492, U10 HD040498, U10
HD040521, U10 HD040689, U10 HD042638, U10 HD21364, U10 HD21373, U10
HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10
HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10
HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40521, U10
HD40689, U10 HD42638]
NR 28
TC 25
Z9 26
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD APR
PY 2009
VL 154
IS 4
BP 498
EP 503
DI 10.1016/j.jpeds.2008.10.044
PG 6
WC Pediatrics
SC Pediatrics
GA 427VU
UT WOS:000264808000010
PM 19111322
ER
PT J
AU Carlo, WA
Wright, LL
Chomba, E
McClure, EM
Carlo, ME
Bann, CM
Collins, M
Harris, H
AF Carlo, Waldemar A.
Wright, Linda L.
Chomba, Elwyn
McClure, Elizabeth M.
Carlo, Maria E.
Bann, Carla M.
Collins, Monica
Harris, Hillary
TI Educational Impact of the Neonatal Resuscitation Program in Low-Risk
Delivery Centers in a Developing Country
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PEDIATRIC RESIDENTS; VITAL-STATISTICS; COURSES
AB Objective To evaluate the effectiveness of the American Academy of Pediatrics Neonatal Resuscitation Program (NRP) in improving knowledge, skills, and self-efficacy of nurse midwives in low-risk delivery clinics in a developing country.
Study design We used the content specifications of the NRP material applicable to college-educated nurse midwives working in low-risk clinics in Zambia to develop performance and self-efficacy evaluations focused on principles of resuscitation, initial steps, ventilation, and chest compressions. These evaluations were administered to 127 nurse midwives before and after NRP training and 6-months later.
Results After training, written scores (knowledge evaluation) improved from 57% +/- 14% to 80% +/- 12% (mean +/- SD; P < .0001); performance scores (skills evaluation) improved the most from 43% +/- 21% to 88% +/- 9% (P < .0001); self-efficacy scores improved from 74% +/- 14% to 90% +/- 10% (P < .0001). Written and performance scores decreased significantly 6 months after training, but self-efficacy scores remained high.
Conclusions As conducted, the NRP training improved educational outcomes in college-educated practicing nurse mid-wives. Pre-training knowledge and skills scores were relatively low despite the advanced formal education and experience of the participants, whereas the self-efficacy scores were high. NRP training has the potential to substantially improve knowledge and skills of neonatal resuscitation. (J Pediatr 2009;154:504-8)
C1 [Carlo, Waldemar A.] Univ Alabama, Div Neonatol, Birmingham, AL 35233 USA.
[Wright, Linda L.] NICHHD, Bethesda, MD 20892 USA.
[Chomba, Elwyn] Univ Zambia, Lusaka, Zambia.
[McClure, Elizabeth M.; Bann, Carla M.; Harris, Hillary] Res Triangle Inst, Durham, NC USA.
RP Carlo, WA (reprint author), Univ Alabama, Div Neonatol, 619 S 20th St,525 New Hillman Bldg, Birmingham, AL 35233 USA.
EM wcarlo@peds.uab.edu
FU NICHD NIH HHS [HD404636, HD43475, U01 HD040636, U01 HD043464, U01
HD043464-08, U01 HD043475]
NR 23
TC 29
Z9 29
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD APR
PY 2009
VL 154
IS 4
BP 504
EP 508
DI 10.1016/j.jpeds.2008.10.005
PG 5
WC Pediatrics
SC Pediatrics
GA 427VU
UT WOS:000264808000011
PM 19058815
ER
PT J
AU Chen, YP
Coulter, S
Jetten, AM
Goldstein, JA
AF Chen, Yuping
Coulter, Sherry
Jetten, Anton M.
Goldstein, Joyce A.
TI Identification of Human CYP2C8 as a Retinoid-Related Orphan Nuclear
Receptor Target Gene
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID CONSTITUTIVE ANDROSTANE RECEPTOR; PREGNANE-X-RECEPTOR; ROR-ALPHA;
GLUCOCORTICOID-RECEPTOR; HUMAN HEPATOCYTES; TRANSCRIPTIONAL REGULATION;
CLINICAL-RELEVANCE; CIRCADIAN CLOCK; CROSS-TALK; EXPRESSION
AB ` Retinoid-related orphan nuclear receptors (RORs) alpha and gamma (NR1F1, -3) are highly expressed in liver, adipose tissue, thymus, and brain and are involved in many physiological processes, such as circadian rhythm and immune function. Enzymes in the cytochrome P450 2C subfamily metabolize many clinically important drugs and endogenous compounds, such as the anticancer drug paclitaxel and arachidonic acid, and are highly expressed in liver. Here, we present the first evidence that RORs regulate the transcription of human CYP2C8. Overexpression of ROR alpha and ROR gamma in HepG2 cells significantly enhanced the activity of the CYP2C8 promoter but not that of the CYP2C9 or CYP2C19 promoters. Computer analyses, promoter deletion studies, gel shift assays, and mutational analysis identified an essential ROR-responsive element at -2045 base pairs in the CYP2C8 promoter that mediates ROR transactivation. Adenoviral overexpression of ROR alpha and -gamma significantly induced endogenous CYP2C8 transcripts in both HepG2 cells and human primary hepatocytes. Knockdown of endogenous ROR alpha and -gamma expression in HepG2 cells by RNA interference decreased the expression of endogenous CYP2C8 mRNA by similar to 50%. These data indicate that RORs transcriptionally upregulate CYP2C8 in human liver and, therefore, may be important modulators of the metabolism of drugs and physiologically active endogenous compounds by this enzyme in liver and possibly extrahepatic tissues where RORs are expressed.
C1 [Chen, Yuping; Coulter, Sherry; Goldstein, Joyce A.] NIEHS, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Jetten, Anton M.] NIEHS, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA.
RP Goldstein, JA (reprint author), NIEHS, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM goldste1@niehs.nih.gov
RI Goldstein, Joyce/A-6681-2012;
OI Coulter, Sherry/0000-0002-2732-3470; Jetten, Anton/0000-0003-0954-4445
FU National Institutes of Health National Institute of Environmental Health
Sciences
FX This work was supported by the Intramural Research Program of the
National Institutes of Health National Institute of Environmental Health
Sciences.
NR 33
TC 14
Z9 16
U1 0
U2 4
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD APR
PY 2009
VL 329
IS 1
BP 192
EP 201
DI 10.1124/jpet.108.148916
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 426KW
UT WOS:000264708200021
PM 19164466
ER
PT J
AU Collins, GT
Truccone, A
Haji-Abdi, F
Newman, AH
Grundt, P
Rice, KC
Husbands, SM
Greedy, BM
Enguehard-Gueiffier, C
Gueiffier, A
Chen, JY
Wang, SM
Katz, JL
Grandy, DK
Sunahara, RK
Woods, JH
AF Collins, Gregory T.
Truccone, Andrew
Haji-Abdi, Faiza
Newman, Amy Hauck
Grundt, Peter
Rice, Kenner C.
Husbands, Stephen M.
Greedy, Benjamin M.
Enguehard-Gueiffier, Cecile
Gueiffier, Alain
Chen, Jianyong
Wang, Shaomeng
Katz, Jonathan L.
Grandy, David K.
Sunahara, Roger K.
Woods, James H.
TI Proerectile Effects of Dopamine D-2-Like Agonists Are Mediated by the
D-3 Receptor in Rats and Mice
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID PENILE ERECTION; SEEKING BEHAVIOR; PARAVENTRICULAR NUCLEUS; INDUCED
REINSTATEMENT; SELECTIVE ANTAGONISM; COCAINE-SEEKING; APOMORPHINE;
ACTIVATION; PD-168077; PIP3EA
AB Dopamine D-2-like agonists induce penile erection (PE) and yawning in a variety of species, effects that have been suggested recently to be specifically mediated by the D-4 and D-3 receptors, respectively. The current studies were aimed at characterizing a series of D-2, D-3, and D-4 agonists with respect to their capacity to induce PE and yawning in the rat and the proerectile effects of apomorphine [(R)-(-)-5,6,6a, 7-tetrahydro-6-methyl-4H-dibenzo-[ de, g] quinoline-10,11-diol hydrochloride] in wild-type and D-4 receptor (R) knockout (KO) mice. All D-3 agonists induced dosedependent increases in PE and yawning over a similar range of doses, whereas significant increases in PE or yawning were not observed with any of the D-4 agonists. Likewise, D-2, D-3, and D-4 antagonists were assessed for their capacity to alter apomorphine-and pramipexole (N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6- diamine dihydrochloride)-induced PE and yawning. The D-3 antagonist, PG01037 [N-{4-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-pyridine-2-yl- benzamide hydrochloride], inhibited the induction of PE and yawning, whereas the D-2 antagonist, L-741,626 [3-[4-(4-chlorophenyl)4- hydroxypiperidin-L-yl] methyl-1H-indole], reversed the inhibition of PE and yawning observed at higher doses. The D-4 antagonist, L-745,870 [3-(4-[4-chlorophenyl] piperazin-1-yl)methyl- 1H-pyrrolo[2,3-b] pyridine trihydrochloride], did not alter apomorphine-or pramipexole-induced PE or yawning. A role for the D-3 receptor was further supported because apomorphine was equipotent at inducing PE in wild-type and D-4 R KO mice, effects that were inhibited by the D-3 antagonist, PG01037, in both wild-type and D-4 R KO mice. Together, these studies provide strong support that D-2-like agonist-induced PE and yawning are differentially mediated by the D-3 (induction) and D-2 (inhibition) receptors. These studies fail to support a role for the D-4 receptor in the regulation of PE or yawning by D-2-like agonists.
C1 [Collins, Gregory T.; Truccone, Andrew; Haji-Abdi, Faiza; Wang, Shaomeng; Sunahara, Roger K.; Woods, James H.] Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA.
[Chen, Jianyong; Wang, Shaomeng] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA.
[Chen, Jianyong; Wang, Shaomeng] Univ Michigan, Sch Med, Dept Med Chem, Ann Arbor, MI 48109 USA.
[Newman, Amy Hauck; Grundt, Peter] NIDA, Med Chem Sect, Intramural Res Program, NIH, Baltimore, MD USA.
[Katz, Jonathan L.] NIDA, Psychobiol Sect, Intramural Res Program, NIH, Baltimore, MD USA.
[Rice, Kenner C.] NIDA, Chem Biol Res Branch, Intramural Res Program, Baltimore, MD USA.
NIAAA, NIH, Bethesda, MD USA.
[Husbands, Stephen M.; Greedy, Benjamin M.] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
[Enguehard-Gueiffier, Cecile; Gueiffier, Alain] Univ Tours, Fac Pharm, Chim Therapeut Lab, Tours, France.
[Grandy, David K.] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA.
RP Collins, GT (reprint author), Univ Michigan, Sch Med, Dept Pharmacol, 1301 MSRB III,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM collinsg@umich.edu
RI Husbands, Stephen/D-5926-2011; Collins, Gregory/K-3125-2012;
OI Katz, Jonathan/0000-0002-1068-1159; Husbands,
Stephen/0000-0002-9928-6322
FU National Institutes of Health [DA020669, F013771, GM068603, MH67497];
National Institutes of Health National Institute on Drug Abuse; National
Institutes of Health National Institute on Alcohol Abuse and Alcoholism;
University of Michigan Biological Sciences Scholars Program
FX This work was supported in part by the National Institutes of Health
[Grants DA020669, F013771, GM068603, MH67497]; by the Intramural
Research program of the National Institutes of Health National Institute
on Drug Abuse and National Institutes of Health National Institute on
Alcohol Abuse and Alcoholism; and by the University of Michigan
Biological Sciences Scholars Program.
NR 34
TC 31
Z9 31
U1 0
U2 2
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD APR
PY 2009
VL 329
IS 1
BP 210
EP 217
DI 10.1124/jpet.108.144048
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 426KW
UT WOS:000264708200023
PM 19136638
ER
PT J
AU Negus, SS
Baumann, MH
Rothman, RB
Mello, NK
Blough, BE
AF Negus, S. S.
Baumann, M. H.
Rothman, R. B.
Mello, N. K.
Blough, B. E.
TI Selective Suppression of Cocaine- versus Food-Maintained Responding by
Monoamine Releasers in Rhesus Monkeys: Benzylpiperazine,
(+)Phenmetrazine, and 4-Benzylpiperidine
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID CHRONIC D-AMPHETAMINE; DISCRIMINATIVE STIMULUS PROPERTIES;
APPETITE-SUPPRESSANTS; OPIOID AGONISTS; CROSS-TOLERANCE; DEPENDENCE;
ABUSE; SEROTONIN; RAT; PHARMACOTHERAPY
AB Monoamine releasers constitute one class of drugs currently under investigation as potential agonist medications for the treatment of cocaine dependence. The efficacy and safety of monoamine releasers as candidate medications may be influenced in part by their relative potency to release dopamine and serotonin, and we reported previously that releasers with approximately 30-fold selectivity for dopamine versus serotonin release may be especially promising. The present study examined the effects of the releasers benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine, which have 20- to 48-fold selectivity in vitro for releasing dopamine versus serotonin. In an assay of cocaine discrimination, rhesus monkeys were trained to discriminate 0.4 mg/kg i.m. cocaine from saline in a two-key, food-reinforced procedure. Each of the releasers produced a dose- and time-dependent substitution for cocaine. 4-Benzylpiperidine had the most rapid onset and shortest duration of action. Phenmetrazine and benzylpiperazine had slower onsets and longer durations of action. In an assay of cocaine self-administration, rhesus monkeys were trained to respond for cocaine injections and food pellets under a second order schedule. Treatment for 7 days with each of the releasers produced a dose- dependent and selective reduction in self-administration of cocaine (0.01 mg/kg/injection). The most selective effects were produced by phenmetrazine. Phenmetrazine also produced a downward shift in the cocaine self-administration dose effect curve, virtually eliminating responding maintained by a 30-fold range of cocaine doses (0.0032-0.1 mg/kg/injection) while having only small and transient effects on food-maintained responding. These findings support the potential utility of dopamine-selective releasers as candidate treatments for cocaine dependence.
C1 [Negus, S. S.] Virginia Commonwealth Univ, Dept Pharmacol, Richmond, VA 23298 USA.
[Negus, S. S.; Mello, N. K.] Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02178 USA.
[Baumann, M. H.; Rothman, R. B.] Natl Inst Drug Abuse, Clin Psychopharmacol Sect, Intramural Res Program, NIH, Baltimore, MD USA.
[Blough, B. E.] Res Triangle Inst, Res Triangle Pk, NC 27709 USA.
RP Negus, SS (reprint author), Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, 410 N 12th St, Richmond, VA 23298 USA.
EM ssnegus@vcu.edu
FU National Institutes of Health [R01-DA02519, R01-DA12970, P01-DA14528,
K05-DA00101]
FX This work was supported in part by the Intramural Research program of
the National Institutes of Health [National Institute on Drug Abuse];
and by the National Institutes of Health [Grants R01-DA02519,
R01-DA12970, P01-DA14528, K05-DA00101].
NR 41
TC 22
Z9 22
U1 0
U2 2
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD APR
PY 2009
VL 329
IS 1
BP 272
EP 281
DI 10.1124/jpet.108.143701
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 426KW
UT WOS:000264708200030
PM 19151247
ER
PT J
AU Birmaher, B
Ehmann, M
Axelson, DA
Goldstein, BL
Monk, K
Kalas, C
Kupfer, D
Gill, MK
Leibenluft, E
Bridge, J
Guyer, A
Egger, HL
Brent, DA
AF Birmaher, Boris
Ehmann, Mary
Axelson, David A.
Goldstein, Benjamin L.
Monk, Kelly
Kalas, Catherine
Kupfer, David
Gill, Mary Kay
Leibenluft, Ellen
Bridge, Jeffrey
Guyer, Amanda
Egger, Helen L.
Brent, David A.
TI Schedule for affective disorders and schizophrenia for school-age
children (K-SADS-PL) for the assessment of preschool children - A
preliminary psychometric study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE K-SADS-PL; Preschoolers; Psychopathology; Reliability; Validity;
Psychometrics
ID TEST-RETEST RELIABILITY; BIPOLAR DISORDER; CONDUCT DISORDER;
EARLY-CHILDHOOD; YOUNG-CHILDREN; ADOLESCENTS; VALIDITY; PSYCHOPATHOLOGY;
PREVALENCE; VERSION
AB Objective: To assess the psychometrics of the schedule for affective disorders and schizophrenia for school-age children present and lifetime version (K-SADS-PL) in diagnosing DSM-IV psychiatric disorders and subsyndromal symptomatology in preschool children.
Method: Parents were interviewed about their children using the K-SADS-PL, and they completed the early childhood inventory-4 (ECI-4) and child behavior checklist for ages 11/2-5 years (CBCL). Discriminant, divergent, and convergent validity of the K-SADS-PL were evaluated in 204 offspring ages 2-5 years old of parents from an ongoing study. Inter-rater reliability as well as predictive validity of intake diagnoses at second assessment approximately two years after intake were evaluated. Fourteen children were also assessed by the preschool age psychiatric assessment (PAPA).
Results: Children who were diagnosed with oppositional defiant disorder, attention deficit hyperactivity disorder, anxiety, mood, or elimination disorders had significantly higher scores on the ECI-4 than children without these disorders. Significant correlations were found for all convergent CBCL scales. Divergent validity was acceptable for emotional disorders. Inter-rater kappa coefficients for all diagnoses were good. Above noted results were similar for children with at least one positive K-SADS-PL key screen symptom. A significantly higher percentage of children with an intake diagnosis had a diagnosis approximately two years after intake compared to those without an intake disorder. Overall, there was consistency between the PAPA and the K-SADS-PL
Conclusions: Pending further testing, the K-SADS-PL may prove useful for the assessment of psychopathology in preschoolers. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Birmaher, Boris; Ehmann, Mary; Axelson, David A.; Goldstein, Benjamin L.; Monk, Kelly; Kalas, Catherine; Kupfer, David; Gill, Mary Kay; Brent, David A.] Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
[Leibenluft, Ellen; Guyer, Amanda] NIMH, Washington, DC USA.
[Bridge, Jeffrey] Ohio State Univ, Nationwide Childrens Hosp, Res Inst, Columbus, OH 43210 USA.
[Bridge, Jeffrey] Ohio State Univ, Columbus Childrens Res Inst, Columbus, OH 43210 USA.
[Egger, Helen L.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Ctr Dev Epidemiol, Durham, NC 27706 USA.
RP Birmaher, B (reprint author), Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM birtmaherb@upmc.edu
OI Egger, Helen/0000-0001-8447-5350
FU NIMH NIH HHS [MH60952, R01 MH060952, R01 MH060952-01A1]
NR 34
TC 43
Z9 46
U1 2
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD APR
PY 2009
VL 43
IS 7
BP 680
EP 686
DI 10.1016/j.jpsychires.2008.10.003
PG 7
WC Psychiatry
SC Psychiatry
GA 437EL
UT WOS:000265469100002
PM 19000625
ER
PT J
AU Pickett, W
Iannotti, RJ
Simons-Morton, B
Dostaler, S
AF Pickett, William
Iannotti, Ronald J.
Simons-Morton, Bruce
Dostaler, Suzanne
TI Social Environments and Physical Aggression Among 21,107 Students in the
United States and Canada
SO JOURNAL OF SCHOOL HEALTH
LA English
DT Article
DE child and adolescent health; public health; risk behaviors; violence
ID RISK BEHAVIOR; SCHOOL-STUDENTS; YOUTH VIOLENCE; MIDDLE SCHOOL;
ADOLESCENTS; CHILDHOOD; HEALTH; VICTIMIZATION; HOMICIDE; CHILDREN
AB Physical aggression is an important issue in North American populations. The importance of students' social environments in the occurrence of physical aggression requires focused study. In this study, reports of physical aggression were examined in relation to social environment factors among national samples of students from Canada and the United States.
Students in grades 6-10 from the United States (n = 14,049) and Canada (n = 7058) who had participated in the Health Behaviour in School-aged Children Survey (HBSC) were studied. Rates of students' physical aggression were compared between the 2 countries. School, family, socioeconomic, and peer-related factors were considered as potential risk factors. A simple social environment risk score was developed using the US data and was subsequently tested in the Canadian sample.
Risks for physical aggression were consistently higher among United States versus Canadian students, but the magnitude of these differences was modest. The relative odds of physical aggression increased with reported environmental risk. To illustrate, US boys in grades 6-8 reporting the highest social environment risk score (5+) experienced a relative odds of physical aggression 4.02 (95% CI 2.7-5.9) times higher than those reporting the lowest score (adjusted OR for risk scores 0 through 5+ was 1.00, 1.19, 2.10, 2.01, 3.71, and 4.02, respectively, p(trend) < .001).
Unexpectedly, rates of physical aggression and associations between social environments and students' aggression were remarkably similar in Canada and the United States. Family, peer, and school social environments serve as risk or protective factors, with significant cumulative impact on physical aggression in both countries. Given the observed high rates and the many negative effects of aggression on long-term health, school policies aimed at the reduction of such behavior remain a clear priority.
C1 [Pickett, William] Kingston Gen Hosp, Dept Community Hlth & Epidemiol, Kingston, ON K7L 2V7, Canada.
[Iannotti, Ronald J.; Simons-Morton, Bruce] Eunice Kennedy Shriver Natl Inst Child Hlth & Dev, Prevent Res Branch, Div Epidemiol Stat & Prevent Res, Bethesda, MD 20892 USA.
[Dostaler, Suzanne] Queens Univ, Dept Emergency Med, Kingston, ON K7L 2V7, Canada.
RP Pickett, W (reprint author), Kingston Gen Hosp, Dept Community Hlth & Epidemiol, Angada 3,76 Stuart St, Kingston, ON K7L 2V7, Canada.
EM will.pickett@queensu.ca; iannottr@mail.nih.gov;
mortonb@exchange.nih.gov; dostaler@queensu.ca
FU Canadian Institutes of Health Research [2004MOP-CHI-128223-C]; Public
Health Agency of Canada [HT089-05205/001/SS]; US Health Resources and
Services Administration; US National Institute of Child Health and Human
Development
FX This study was supported financially, in part, by the Canadian
Institutes of Health Research (operating grant 2004MOP-CHI-128223-C),
the Public Health Agency of Canada (Contract: HT089-05205/001/SS), the
US Health Resources and Services Administration, and the US National
Institute of Child Health and Human Development. HBSC is a World Health
Organization/European Region collaborative study. The international
coordinator of the 2001/2002 study is Candace Currie, University of
Edinburgh, Scotland; and the data bank manager is Oddrun Samdal,
University of Bergen, Norway. We thank Matthew King (national
coordinator), Dr. Will Boyce (principal investigator), and Danielle
Shelley from the Canadian HBSC team and Dr. Mary Overpeck (principal
investigator) and Kimberly Chambers from the US HBSC team.
NR 43
TC 10
Z9 10
U1 2
U2 5
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4391
J9 J SCHOOL HEALTH
JI J. Sch. Health
PD APR
PY 2009
VL 79
IS 4
BP 160
EP 168
DI 10.1111/j.1746-1561.2009.00385.x
PG 9
WC Education & Educational Research; Education, Scientific Disciplines;
Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Education & Educational Research; Health Care Sciences & Services;
Public, Environmental & Occupational Health
GA 416SA
UT WOS:000264024600003
PM 19292848
ER
PT J
AU Zhu, YY
Huang, XL
Wang, W
Lopresti, D
Long, R
Antani, S
Xue, ZY
Thoma, G
AF Zhu, Yaoyao
Huang, Xiaolei
Wang, Wei
Lopresti, Daniel
Long, Rodney
Antani, Sameer
Xue, Zhiyun
Thoma, George
TI Balancing the Role of Priors in Multi-Observer Segmentation Evaluation
SO JOURNAL OF SIGNAL PROCESSING SYSTEMS FOR SIGNAL IMAGE AND VIDEO
TECHNOLOGY
LA English
DT Article
DE Ground truth; Bayesian decision; Precision; Segmentation;
Multi-observer; Sensitivity; Specificity; STAPLE; Validation
ID IMAGE SEGMENTATION
AB Comparison of a group of multiple observer segmentations is known to be a challenging problem. A good segmentation evaluation method would allow different segmentations not only to be compared, but to be combined to generate a "true" segmentation with higher consensus. Numerous multi-observer segmentation evaluation approaches have been proposed in the literature, and STAPLE in particular probabilistically estimates the true segmentation by optimal combination of observed segmentations and a prior model of the truth. An Expectation-Maximization (EM) algorithm, STAPLE's convergence to the desired local minima depends on good initializations for the truth prior and the observer-performance prior. However, accurate modeling of the initial truth prior is nontrivial. Moreover, among the two priors, the truth prior always dominates so that in certain scenarios when meaningful observer-performance priors are available, STAPLE can not take advantage of that information. In this paper, we propose a Bayesian decision formulation of the problem that permits the two types of prior knowledge to be integrated in a complementary manner in four cases with differing application purposes: (1) with known truth prior; (2) with observer prior; (3) with neither truth prior nor observer prior; and (4) with both truth prior and observer prior. The third and fourth cases are not discussed (or effectively ignored) by STAPLE, and in our research we propose a new method to combine multiple-observer segmentations based on the maximum a posterior (MAP) principle, which respects the observer prior regardless of the availability of the truth prior. Based on the four scenarios, we have developed a web-based software application that implements the flexible segmentation evaluation framework for digitized uterine cervix images. Experiment results show that our framework has flexibility in effectively integrating different priors for multi-observer segmentation evaluation and it also generates results comparing favorably to those by the STAPLE algorithm and the Majority Vote Rule.
C1 [Zhu, Yaoyao; Huang, Xiaolei; Wang, Wei; Lopresti, Daniel] Lehigh Univ, Dept Comp Sci & Engn, Bethlehem, PA 18015 USA.
[Long, Rodney; Antani, Sameer; Xue, Zhiyun; Thoma, George] Natl Inst Hlth, Natl Lib Med, Bethesda, MD 20894 USA.
RP Zhu, YY (reprint author), Lehigh Univ, Dept Comp Sci & Engn, Bethlehem, PA 18015 USA.
EM yaz304@lehigh.edu; xih206@lehigh.edu; wew305@lehigh.edu;
dal9@lehigh.edu; rlong@mail.nih.gov; santani@mail.nih.gov;
xuez@mail.nih.gov; gthoma@mail.nih.gov
OI Antani, Sameer/0000-0002-0040-1387
NR 20
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1939-8018
J9 J SIGNAL PROCESS SYS
JI J. Signal Process. Syst. Signal Image Video Technol.
PD APR
PY 2009
VL 55
IS 1-3
BP 185
EP 207
DI 10.1007/s11265-008-0215-5
PG 23
WC Computer Science, Information Systems; Engineering, Electrical &
Electronic
SC Computer Science; Engineering
GA 418FI
UT WOS:000264133700015
ER
PT J
AU Goel, G
Krekelberg, WP
Pond, MJ
Mittal, J
Shen, VK
Errington, JR
Truskett, TM
AF Goel, Gaurav
Krekelberg, William P.
Pond, Mark J.
Mittal, Jeetain
Shen, Vincent K.
Errington, Jeffrey R.
Truskett, Thomas M.
TI Available states and available space: static properties that predict
self-diffusivity of confined fluids
SO JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
LA English
DT Article
DE structural correlations (theory); fluids in confined geometries;
interfacial phenomena and wetting; diffusion; molecular dynamics
ID FUNDAMENTAL-MEASURE-THEORY; DENSITY-FUNCTIONAL THEORY; BROWNIAN-MOTION;
FREE-ENERGY; SPHERE; WALLS; EQUILIBRIUM; TRANSPORT; MIXTURES; DYNAMICS
AB Although classical density functional theory provides reliable predictions for the static properties of simple equilibrium fluids under confinement, a theory of comparative accuracy for the transport coefficients has yet to emerge. Nonetheless, there is evidence that knowledge of how confinement modifies static behavior can aid in forecasting dynamics. Specifically, recent molecular simulation studies have shown that the relationship between excess entropy and self-diffusivity of a bulk equilibrium fluid changes only modestly when the fluid is isothermally confined, indicating that knowledge of the former might allow semi-quantitative predictions of the latter. Do other static measures, such as those that characterize free or available volume, also strongly correlate with single-particle dynamics of confined fluids? Here, we investigate this question for both the single-component hard-sphere fluid and hard-sphere mixtures. Specifically, we use molecular simulations and fundamental measure theory to study these systems at approximately 10(3) equilibrium state points. We examine three different confining geometries (slit pore, square channel, and cylindrical pore) and the effects of particle packing fraction and particle-boundary interactions. Although average density fails to predict some key qualitative trends for the self-diffusivity of confined fluids, we provide strong empirical evidence that a new generalized measure of available volume for inhomogeneous fluids correlates excellently with self-diffusivity across a wide parameter space in these systems, approximately independently of the degree of confinement. An important consequence, which we demonstrate here, is that density functional theory predictions of this static property can be used together with knowledge of bulk fluid behavior to semi-quantitatively estimate the self-diffusion coefficient of confined fluids under equilibrium conditions.
C1 [Goel, Gaurav; Krekelberg, William P.; Pond, Mark J.; Truskett, Thomas M.] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA.
[Mittal, Jeetain] NIDDK, Chem Phys Lab, Natl Inst Hlth, Bethesda, MD 20892 USA.
[Shen, Vincent K.] NIST, Chem & Biochem Reference Data Div, Gaithersburg, MD 20899 USA.
[Errington, Jeffrey R.] SUNY Buffalo, Dept Chem & Biol Engn, Buffalo, NY 14260 USA.
[Truskett, Thomas M.] Univ Texas Austin, Inst Theoret Chem, Austin, TX 78712 USA.
RP Goel, G (reprint author), Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA.
EM goel@che.utexas.edu; krekel@che.utexas.edu; mjp736@che.utexas.edu;
jeetain@helix.nih.gov; vincent.shen@nist.gov; jerring@buffalo.edu;
truskett@che.utexas.edu
RI Truskett, Thomas/D-4624-2009; Errington, Jeffrey/E-8644-2011; Truskett,
Thomas/C-4996-2014
OI Truskett, Thomas/0000-0002-6607-6468; Errington,
Jeffrey/0000-0003-0365-0271;
FU National Science Foundation (NSF) [CTS-0448721]; Welch Foundation
[F-1696]; David and Lucile Packard Foundation; Alfred P Sloan
Foundation; NSF Graduate Research Fellowship; UT ChE department
fellowship; National Institute of Diabetes and Digestive and Kidney
Diseases Intramural Research Program
FX TMT acknowledges support of the National Science Foundation (NSF) under
Grant No. CTS-0448721, the Welch Foundation (F-1696), the David and
Lucile Packard Foundation, and the Alfred P Sloan Foundation. WPK and GG
acknowledge support from a NSF Graduate Research Fellowship and a UT ChE
department fellowship, respectively. JM was supported by the National
Institute of Diabetes and Digestive and Kidney Diseases Intramural
Research Program. The Texas Advanced Computing Center (TACC), the
Biowulf PC/Linux cluster at the National Institutes of Health, Bethesda,
MD, and the University at Buffalo Center for Computational Research
provided computational resources for this study.
NR 40
TC 30
Z9 30
U1 0
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 1742-5468
J9 J STAT MECH-THEORY E
JI J. Stat. Mech.-Theory Exp.
PD APR
PY 2009
AR P04006
DI 10.1088/1742-5468/2009/04/P04006
PG 19
WC Mechanics; Physics, Mathematical
SC Mechanics; Physics
GA 440DQ
UT WOS:000265680300007
ER
PT J
AU Sundaram, R
AF Sundaram, Rajeshwari
TI Semiparametric inference of proportional odds model based on randomly
truncated data
SO JOURNAL OF STATISTICAL PLANNING AND INFERENCE
LA English
DT Article
DE Proportional odds model; Weighted empirical processes; Minimum distance;
Truncation; Survival
ID REGRESSION-MODEL; CENSORED-DATA; TRANSFORMATION MODELS; SURVIVAL-DATA;
LIKELIHOOD; AIDS
AB This paper Studies the estimation in the proportional odds model based on randomly truncated data. The proposed estimators for the regression coefficients include a class of minimum distance estimators defined through weighted empirical odds function. We have investigated the asymptotic properties like the consistency and the limiting distribution of the proposed estimators tinder mild conditions. The finite sample properties were investigated through simulation Study making comparison of some of the estimators in the class. We conclude with an illustration of our proposed method to a well-known AIDS data. Published by Elsevier B.V
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, DHHS, Rockville, MD 20852 USA.
RP Sundaram, R (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, DHHS, 6100 Execut Blvd, Rockville, MD 20852 USA.
EM sundaramr2@mail.nih.gov
OI Sundaram, Rajeshwari/0000-0002-6918-5002
FU NIH; NICHD
FX This research was supported by the Intramural Research Program of the
NIH, NICHD.
NR 31
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3758
EI 1873-1171
J9 J STAT PLAN INFER
JI J. Stat. Plan. Infer.
PD APR 1
PY 2009
VL 139
IS 4
BP 1381
EP 1393
DI 10.1016/j.jspi.2008.08.006
PG 13
WC Statistics & Probability
SC Mathematics
GA 398VY
UT WOS:000262760800010
PM 21976786
ER
PT J
AU Mo, QX
Lu, SF
Garippa, C
Brownstein, MJ
Simon, NG
AF Mo, Qianxing
Lu, Shifang
Garippa, Carrie
Brownstein, Michael J.
Simon, Neal G.
TI Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse
hypothalamus and hippocampus
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Article
DE Dehydroepiandrosterone (DHEA); Androgen receptor; Genomics; CNS;
Mechanism of action
ID KINASE-C-DELTA; MELANIN-CONCENTRATING HORMONE; NEURAL ANDROGEN RECEPTOR;
PLACEBO-CONTROLLED TRIAL; DEHYDROEPIANDROSTERONE DHEA; TRANSCRIPTIONAL
ACTIVITY; ADRENAL INSUFFICIENCY; RAT-BRAIN; ENERGY HOMEOSTASIS;
FEEDING-BEHAVIOR
AB Dehydroepiandrosterone (DHEA) is the most abundant steroid in humans and a multi-functional neuroactive steroid that has been implicated in a variety of biological effects in both the periphery and central nervous system. Mechanistic studies of DHEA in the periphery have emphasized its role as a prohormone and those in the brain have focused on effects exerted at cell surface receptors. Recent results demonstrated that DHEA is intrinsically androgenic. It competes with DHT for binding to androgen receptor (AR), induces AR-regulated reporter gene expression in vitro, and exogenous DHEA administration regulates gene expression in peripheral androgen-dependent tissues and LnCAP prostate cancer cells, indicating genomic effects and adding a level of complexity to functional models. The absence of information about the effect of DHEA on gene expression in the CNS is a significant gap in light of continuing clinical interest in the compound as a hormone replacement therapy in older individuals, patients with adrenal insufficiency, and as a treatment that improves sense of well-being, increases libido, relieves depressive symptoms, and serves as a neuroprotective agent. In the present study, ovariectomized CF-1 female mice, an established model for assessing CNS effects of androgens, were treated with DHEA (1 mg/day), dihydrotestosterone (DHT, a potent androgen used as a positive control; 0.1 mg/day) or vehicle (negative control) for 7 days. The effects of DHEA on gene expression were assessed in two regions of the CNS that are enriched in AR, hypothalamus and hippocampus, using DNA microarray, real-time RT-PCR, and immunohistochemistry. RIA of serum samples assessed treatment effects on circulating levels of major steroids. In hypothalamus, DHEA and DHT significantly up-regulated the gene expression of hypocretin (Hcrt; also called orexin), pro-melanin-concentrating hormone (Pmch), and protein kinase C delta (Prkcd), and down-regulated the expression of deleted in bladder cancer chromosome region candidate I (Dbccr1) and chitinase 3-like 3 (Chi313). Two-step real-time RT-PCR confirmed changes in the expression of three genes (Pmch, Hcrt and Prkcd) using the same RNA sample employed in the microarray experiment. Immunohistochemistry showed augmentation of prepto-hypocretin (pHcrt) neuropeptide protein expression by DHEA and DHT in hypothalamus, consistent with the localization of orexin neurons. In hippocampus, DHT down-regulated the expression of Prkcd, while DHEA did not have significant effects. RIA results supported the view that DHEA-induced effects were mediated through AR. The current study identified neurogenomic effects of DHEA treatment on a subset of genes directly implicated in the regulation of appetite, energy utilization, alertness, apoptosis, and cell survival. These changes in gene expression in the CNS represent a constellation of effects that may help explain the diverse benefits attributed to replacement therapy with DHEA. The data also provide a new level of detail regarding the genomic mechanism of action of DHEA in the CNS and strongly support a central role for the androgen receptor in the production of these effects. More broadly, the results may be clinically significant because they provide new insights into processes that appear to mediate the diverse CNS effects attributed to DHEA. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Mo, Qianxing; Lu, Shifang; Garippa, Carrie; Simon, Neal G.] Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA.
[Brownstein, Michael J.] NIMH, Rockville, MD 20850 USA.
RP Mo, QX (reprint author), Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
EM ngs0@lehigh.edu
FU NIH [MH59300]; H.F. Guggenheim Foundation
FX The authors thank Dr. Jutta Marzillier for technical support in the
microarray experiment, and Dr. Wei-Min Huang for help with the
statistical analysis. Supported in part by grants from NIH (MH59300) and
the H.F. Guggenheim Foundation to N.G.S.
NR 86
TC 12
Z9 12
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD APR
PY 2009
VL 114
IS 3-5
BP 135
EP 143
DI 10.1016/j.jsbmb.2009.01.015
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 437QX
UT WOS:000265503100003
PM 19429443
ER
PT J
AU Heymann, JAW
Shi, D
Kim, S
Bliss, D
Milne, JLS
Subramaniam, S
AF Heymann, Jurgen A. W.
Shi, Dan
Kim, Sang
Bliss, Donald
Milne, Jacqueline L. S.
Subramaniam, Sriram
TI 3D Imaging of mammalian cells with ion-abrasion scanning electron
microscopy
SO JOURNAL OF STRUCTURAL BIOLOGY
LA English
DT Article
DE Automated 3D imaging; Melanoma detection; Mitochondrial architecture;
Dual beam microscopy; Cancer imaging
ID CRYOELECTRON MICROSCOPY; ENDOPLASMIC-RETICULUM; MITOCHONDRIA;
TOMOGRAPHY; VISUALIZATION; MELANOSOMES; SPECIMENS
AB Understanding the hierarchical organization of molecules and organelles within the interior of large eukaryotic cells is a challenge of fundamental interest in cell biology. We are using ion-abrasion scanning electron microscopy (IA-SEM) to visualize this hierarchical organization in an approach that combines focused ion-beam milling with scanning electron microscopy. Here, we extend our previous studies on imaging yeast cells to image subcellular architecture in human melanoma cells and melanocytes at resolutions as high as similar to 6 and similar to 20 nm in the directions parallel and perpendicular, respectively, to the direction of ion-beam milling. The 3D images demonstrate the striking spatial relationships between specific organelles such as mitochondria and membranes of the endoplasmic reticulum, and the distribution of unique cellular components such as melanosomes. We also show that 10 nm-sized gold particles and quantum dot particles with 7 nm-sized cores can be detected in single cross-sectional images. IA-SEM is thus a useful tool for imaging large mammalian cells in their entirety at resolutions in the nanometer range. Published by Elsevier Inc.
C1 [Heymann, Jurgen A. W.; Shi, Dan; Kim, Sang; Bliss, Donald; Milne, Jacqueline L. S.; Subramaniam, Sriram] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Subramaniam, S (reprint author), NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bldg 50,Room 4306, Bethesda, MD 20892 USA.
EM ss1@nih.gov
FU Intramural NIH HHS [Z01 BC010278-11]
NR 28
TC 66
Z9 67
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1047-8477
J9 J STRUCT BIOL
JI J. Struct. Biol.
PD APR
PY 2009
VL 166
IS 1
BP 1
EP 7
DI 10.1016/j.jsb.2008.11.005
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 417MU
UT WOS:000264081000001
PM 19116171
ER
PT J
AU Sternheim, A
Bickels, J
Ben-Tov, T
Malawer, MM
AF Sternheim, Amir
Bickels, Jacob
Ben-Tov, Tomer
Malawer, Martin M.
TI Space Sarcomas: Extra Compartmental Soft Tissue Tumors of the Lower
Extremities A Systematic Approach to Sarcomas of the Femoral Triangle,
Sartorial Canal, and Popliteal Space
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE soft tissue sarcoma; extracompartmental space tumors; resection
technique
ID FLEXOR FOSSAE; AMPUTATION; RESECTION; SURVIVAL
AB Background: Extra-compartmental soft tissue sarcomas may grow in virtual spaces in close proximity to major neurovascular structures and thus, require a complex resection. We analyzed the general principles by which these resections are planned.
Methods: We retrospectively analyzed 53 patients with sarcomas located in the femoral triangle (15), sartorial canal ( 16), and the popliteal fossa (22). These lesions were grouped into three categories based on involvement of spatial structure; neurovascular involvement = 13, musculofascial involvement = 19 and no involvement = 11.
Results: Limb sparing Surgery was feasible in lesions that had either 110 Structural or musculofascial involvement. Amputation, however, was required in 3 of 13 patients with neurovascular involvement because of gross involvement of the surrounding tissues. Overall, limb sparing, was feasible in 94% (50 of 53 patients). The 2- and 5-year local recurrence rates were 10% and 14%, respectively. Five-year survival was 88%.
Conclusions: Limb sparing resection of space sarcomas is feasible in the majority of extra-compartmental sarcomas by utilizing a systematic approach which emphasizes specific planes of resection. J. Surg. Oncol. 2009;99:281-291. (C) 2009 Wiley-Liss, Inc.
C1 [Sternheim, Amir; Bickels, Jacob; Ben-Tov, Tomer; Malawer, Martin M.] Washington Hosp Ctr, Washington Canc Inst, Dept Orthoped Oncol, Washington, DC 20010 USA.
[Malawer, Martin M.] Georgetown Univ, Washington, DC USA.
[Malawer, Martin M.] NCI, Pediat & Surg Branch, Bethesda, MD 20892 USA.
RP Sternheim, A (reprint author), Washington Hosp Ctr, Washington Canc Inst, Dept Orthoped Oncol, C2173,110 Irving St NW, Washington, DC 20010 USA.
EM Amirsternheim@gmail.com
NR 14
TC 2
Z9 3
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0022-4790
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD APR 1
PY 2009
VL 99
IS 5
BP 281
EP 291
DI 10.1002/jso.21223
PG 11
WC Oncology; Surgery
SC Oncology; Surgery
GA 429FP
UT WOS:000264906600004
PM 19143031
ER
PT J
AU Merikangas, KR
Avenevoli, S
Costello, EJ
Doreen, K
Kessler, RC
AF Merikangas, Kathleen R.
Avenevoli, Shelli
Costello, E. Jane
Koretz, Doreen
Kessler, Ronald C.
TI National Comorbidity Survey Replication Adolescent Supplement (NCS-A):
I. Background and Measures
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Review
DE adolescent mental disorders; National Comorbidity Survey Replication
Adolescent Supplement; Composite International Diagnostic Interview;
mental disorders; epidemiology
ID CHILDRENS MENTAL-HEALTH; DIAGNOSTIC INTERVIEW SCHEDULE; MAJOR DEPRESSIVE
DISORDER; PSYCHOSOCIAL RISK-FACTORS; SCHOOL-AGE-CHILDREN; III-R
DISORDERS; PSYCHIATRIC-DISORDERS; ANXIETY DISORDERS; SERVICE USE;
CHILDHOOD PSYCHOPATHOLOGY
AB Objective: This article presents an overview of the background and measures used in the National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Method: The NCS-A is a national psychiatric epidemiological survey of adolescents aged 13 to 17 years. Results: The NCS-A was designed to provide the first nationally representative estimates of the prevalence, correlates, and patterns of service use for DSM-IV mental disorders among U.S. adolescents and to lay the groundwork for follow-up studies of risk and protective factors, consequences, and early expressions of adult mental disorders. The core NCS-A diagnostic interview, the World Health Organization Composite International Diagnostic Interview, is a fully structured research diagnostic interview designed for use by trained lay interviewers. A multiconstruct, multimethod, and multi-informant battery was also included to assess risk and protective factors and barriers to service use. Design limitations due to the NCS-A evolving as a supplement to an ongoing survey of mental disorders of U.S. adults include restricted age range of youths, cross-sectional assessment, and lack of full parental/surrogate informant reports on youth mental disorders and correlates. Conclusions: Despite these limitations, the NCS-A contains unparalleled information that can be used to generate national estimates of prevalence and correlates of adolescent mental disorders, risk and protective factors, patterns of service use, and barriers to receiving treatment for these disorders. The retrospective NCS-A data on the development of psychopathology can additionally complement data from longitudinal studies based on more geographically restricted samples and serve as a useful baseline for future prospective studies of the onset and progression of mental disorders in adulthood. J. Am. Acad Child Adolesc. Psychiatry, 2009;48(4):367-379.
C1 [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Merikangas, Kathleen R.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
[Avenevoli, Shelli] NIMH, Div Dev Translat Res, Bethesda, MD USA.
[Costello, E. Jane] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Dev Epidemiol, Durham, NC 27706 USA.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA.
EM kessler@hcp.med.harvard.edu
FU National Institute of Mental Health [U01MH60220]; National Institute on
Drug Abuse; Substance Abuse and Mental Health Services Administration;
Robert Wood Johnson Foundation [044780]; John W Alden Trust; NIMH
[R01-MH66627]
FX The National Comorbidity Survey Replication Adolescent Supplement
(NCS-A) is supported by the National Institute of Mental Health (NIMH;
Grant U01MH60220) with supplemental support from the National Institute
on Drug Abuse, the Substance Abuse and Mental Health Services
Administration, the Robert Wood Johnson Foundation (Grant 044780), and
the John W Alden Trust. The work of Dr. Merikangas and her staff on the
NCS-A is supported by the NIMH Intramural Research Program, whereas the
work of Dr Zaslavsky and his staff on the validity of the NCS A measures
is supported by NIMH Grant R01-MH66627 The views and opinions expressed
in this article are those of the authors and should not be construed to
represent the views of any of the sponsoring organizations, agencies, or
U.S. Government. A complete list of NCS-A publications can be found at
http://www.btp.medbaruardedulna.
NR 118
TC 106
Z9 107
U1 8
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD APR
PY 2009
VL 48
IS 4
BP 367
EP 379
DI 10.1097/CHI.0b013e31819996f1
PG 13
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 423PI
UT WOS:000264507800004
PM 19242382
ER
PT J
AU Kessler, RC
Avenevoli, S
Jane, C
Green, JG
Gruber, MJ
Heeringa, S
Merikangas, KR
Pennell, BE
Sampson, NA
Zaslavsky, AM
AF Kessler, Ronald C.
Avenevoli, Shelli
Costello, Jane
Green, Jennifer Greif
Gruber, Michael J.
Heeringa, Steven
Merikangas, Kathleen R.
Pennell, Beth-Ellen
Sampson, Nancy A.
Zaslavsky, Alan M.
TI National Comorbidity Survey Replication Adolescent Supplement (NCS-A):
II. Overview and Design
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE National Comorbidity Survey Replication Adolescent Supplement; mental
disorders; epidemiology; survey design; survey sampling
AB Objective: To present an overview of the design and field procedures of the National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Method: The NCS-A is a nationally representative face-to-face household survey of the prevalence and correlates of DSM-IV mental disorders among U.S. adolescents (aged 13-17 years) that was performed between February 2001 and January 2004 by the Survey Research Center of the Institute for Social Research at the University of Michigan. The sample was based on a dual-frame design that included 904 adolescent residents of the households that participated in the National Comorbidity Survey Replication (response rate 85.9%) and 9,244 adolescent students selected from a representative sample of 320 schools in the same nationally representative sample of counties as the National Comorbidity Survey Replication (response rate 74.7%). Results: Comparisons of sample and population distributions on census sociodemographic variables and, in the school sample, school characteristics documented only minor differences that were corrected with poststratification weighting. Comparisons of DSM-IV disorder prevalence estimates among household versus school sample respondents in counties that differed in the use of replacement schools for originally selected schools that refused to participate showed that the use of replacement schools did not introduce bias into prevalence estimates. Conclusions: The NCS-A is a rich nationally representative dataset that will substantially increase understanding of the mental health and well-being of adolescents in the United States. J. Am. Acad. Child Adolesc. Psychiatry, 2009;48(4):380-385.
C1 [Kessler, Ronald C.; Green, Jennifer Greif; Gruber, Michael J.; Sampson, Nancy A.; Zaslavsky, Alan M.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Avenevoli, Shelli] NIMH, Div Dev Translat Res, Bethesda, MD USA.
[Costello, Jane] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Dev Epidemiol, Durham, NC 27706 USA.
[Heeringa, Steven; Pennell, Beth-Ellen] Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48109 USA.
[Merikangas, Kathleen R.] NIMH, Intramural Res Program, Genet Epidemiol Branch, Bethesda, MD USA.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA.
EM Kessler@hcp.med.harvard.edu
FU National Institute of Mental Health [U01MH60220, R01-MH66627]; Substance
Abuse and Mental Health Services Administration; Robert Wood Johnson
Foundation [044780]; John W Alders Taut
FX The National Comorbidity Survey Replication Adolescent Supplement (NCS
A) is supported by the National Institute of Mental Health (NIMH; Grant
U01MH60220) with supplemental support from the National Institute on
Drug Abuse, the Substance Abuse and Mental Health Services
Administration, the Robert Wood Johnson Foundation (Grant 044780), and
the John W Alders Taut. The work of Dr Merikangas and her staff on the
NCS-A is supported by the NIMH Intramural Research Program, whereas the
work of Dr. Zaslavsky and his staff on the validity of the NCS-A
measures is supported by NIMH Grant R01-MH66627. The views and opinions
expressed in this article are those of the authors and should not be
construed to represent the views of any of the sponsoring organizations,
agencies, or US. Government. A complete list of NCS-A publications can
be found at http:://www.hcp.nred.harvard edulrics.
NR 7
TC 94
Z9 95
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD APR
PY 2009
VL 48
IS 4
BP 380
EP 385
DI 10.1097/CHI.0b013e3181999705
PG 6
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 423PI
UT WOS:000264507800005
PM 19242381
ER
PT J
AU Kessler, RC
Avenevoli, S
Green, J
Gruber, MJ
Guyer, M
He, Y
Jin, R
Kaufman, J
Sampson, NA
Zaslavsky, AM
Merikangas, KR
AF Kessler, Ronald C.
Avenevoli, Shelli
Green, Jennifer
Gruber, Michael J.
Guyer, Margaret
He, Yulei
Jin, Robert
Kaufman, Joan
Sampson, Nancy A.
Zaslavsky, Alan M.
Merikangas, Kathleen R.
TI National Comorbidity Survey Replication Adolescent Supplement (NCS-A):
III. Concordance of DSM-IV/CIDI Diagnoses With Clinical Reassessments
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE National Comorbidity Survey Replication Adolescent Supplement; Composite
International Diagnostic Interview; mental disorders; epidemiology;
validity
ID PSYCHIATRIC-ASSESSMENT CAPA; WORLD-HEALTH-ORGANIZATION; DISORDER
SEVERITY SCALE; PARENT-CHILD AGREEMENT; INTERVIEW SCHEDULE; MAJOR
DEPRESSION; UNITED-STATES; K-SADS; VALIDITY; CIDI
AB Objective: To report results of the clinical reappraisal study of lifetime DSM-IV diagnoses based on the fully structured lay-administered World Health Organization Composite International Diagnostic Interview (CIDI) Version 3.0 in the U.S. National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Method: Blinded clinical reappraisal interviews with a probability subsample of 347 NCS-A respondents were administered using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) as the gold standard. The DSM-IV/CIDI cases were oversampled, and the clinical reappraisal sample was weighted to adjust for this oversampling. Results: Good aggregate consistency was found between CIDI and K-SADS prevalence estimates, although CIDI estimates were meaningfully higher than K-SADS estimates for specific phobia (51.2%) and oppositional defiant disorder (38.7%). Estimated prevalence of any disorder, in comparison, was only slightly higher in the CIDI than K-SADS (8.3%). Strong individual-level CIDI versus K-SADS concordance was found for most diagnoses. Area under the receiver operating characteristic curve, a measure of classification accuracy not influenced by prevalence, was 0.88 for any anxiety disorder, 0.89 for any mood disorder, 0.84 for any disruptive behavior disorder, 0.94 for any substance disorder, and 0.87 for any disorder. Although area under the receiver operating characteristic curve was unacceptably low for alcohol dependence and bipolar I and II disorders, these problems were resolved by aggregation with alcohol abuse and bipolar I disorder, respectively. Logistic regression analysis documented that consideration of CIDI symptom-level data significantly improved prediction of some K-SADS diagnoses. Conclusions: These results document that the diagnoses made in the NCS-A based on the CIDI have generally good concordance with blinded clinical diagnoses. J. Am. Acad. Child Adolesc. Psychiatry, 2009;48(4):386-399.
C1 [Kessler, Ronald C.; Green, Jennifer; Gruber, Michael J.; He, Yulei; Sampson, Nancy A.; Zaslavsky, Alan M.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Avenevoli, Shelli] NIMH, Div Dev Translat Res, Bethesda, MD USA.
[Guyer, Margaret] Massachusetts Mental Hlth Ctr, Bethesda, MD USA.
[Kaufman, Joan] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
[Merikangas, Kathleen R.] NIMH, Genet Epidemiol Branch, Intramural Res Program, Bethesda, MD USA.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA.
EM kessler@hcp.med.harvard.edu
FU National Institute of Mental Health [U01-MH60220, R01-MH66627,
R01-MH070884, R13-MH066849, R01-AIH069864, R01-MH077883]; National
Institute on Drug Abuse; Substance Abuse and Mental Health Services
Administration; Robert Wood Johnson Foundation [044780]; John W. Allen
Trust; NIMH Intramural Research Program; National Institute on Drug
Abuse [R01-DA016558]; Fogarty International Center of the National
Institutes of Health [R03-TW006481]; John D. and Catherine T. MacArthur
Foundation; Pfizer Foundation; Pan American Health Organization;
AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company;
GlaxoSmithKline; Ortho-McNeil; Pfizer; Sanofi-Aventis
FX The NCS-A is performed in conjunction with the World Health Organization
World Mental Health (WIMH) Survey Initiative. The authors thank the
staff of the WMH Coordination Centers for assistance with
instrumentation, fieldwork, and consultation on data analysis. The WMH
Data Coordination Centers have received support front NIMH (Grants
R01-MH070884. Rl3-MH066849, ROl-AIH069864, and ROT-MH077883), National
Institute on Drug Abuse (Grant R01-DA016558), the Fogarty International
Center of the National Institutes of Health (Grant R03-TW006481), the
John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation,
and the Pan American Health Organization. The WMH Data Coordination
Centers have also received unrestricted educational grants from
AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Company,
GlaxoSmithKline, Ortho-McNeil, Pfizer, Sanofi-Aventis, and Wyeth. A
complete list of WMH publications can be found
athup://www.hep.coed.harvard.edulwmh.
NR 66
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U1 5
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD APR
PY 2009
VL 48
IS 4
BP 386
EP 399
DI 10.1097/CHI.0b013e31819a1cbc
PG 14
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 423PI
UT WOS:000264507800006
PM 19252450
ER
PT J
AU Stringaris, A
Goodman, R
AF Stringaris, Argyris
Goodman, Robert
TI Longitudinal Outcome of Youth Oppositionality: Irritable, Headstrong,
and Hurtful Behaviors Have Distinctive Predictions
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE oppositional defiant disorder; depression; comorbidity; emotional
disorders; attention-deficit/hyperactivity disorder
ID DEFIANT DISORDER; CONDUCT DISORDER; DIFFICULTIES QUESTIONNAIRE;
ADOLESCENT PSYCHOPATHOLOGY; PSYCHOMETRIC PROPERTIES; ANXIETY DISORDERS;
PREVALENCE; STRENGTHS; SAMPLE; CHILD
AB Objective: Oppositional behavior in youths is one of the strongest predictors of a wide range of psychiatric disorders. We test the hypothesis that oppositionality encompasses an Irritable, a Headstrong, and a Hurtful dimension, each with distinct predictions. Method: Longitudinal design combining data from two British national surveys and their respective 3-year follow-ups (N = 7,912). The Developmental and Well-Being Assessment was used to generate DSM-IV diagnoses. Results: The Irritable dimension was the sole predictor of emotional disorders at follow-up and was particularly associated with distress disorders (depression and anxiety) rather than fear disorders (phobias, separation anxiety, and panic disorder), both before and after adjustment for baseline psychopathology. The Headstrong dimension was the only predictor of attention-deficit/hyperactivity disorder at follow-up. Both Headstrong and Hurtful predicted conduct disorder, although only the Headstrong dimension did so after adjustment for baseline psychopathology. The Hurtful dimension was the strongest predictor of aggressive conduct disorder symptoms. Conclusions: Our data suggest a developmental model of mental disorder whereby oppositionality is an interim shared manifestation of different dimensions of psychopathology with distinct outcomes. J. Am. Acad. Child Adolesc. Psychiatry, 2009;48(4):404-412.
C1 [Stringaris, Argyris; Goodman, Robert] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
RP Stringaris, A (reprint author), NIMH, Sect Bipolar Spectrum Disorders, Emot & Dev Branch, Mood & Anxiety Program, Bldg 15K, Bethesda, MD 20892 USA.
EM stringarisa@mail.nih.gov
FU British Department of Health
FX The study was funded by the British Department of Health.
NR 37
TC 154
Z9 154
U1 2
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD APR
PY 2009
VL 48
IS 4
BP 404
EP 412
DI 10.1097/CHI.0b013e3181984f30
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 423PI
UT WOS:000264507800008
PM 19318881
ER
PT J
AU Givens, JL
Frederick, M
Silverman, L
Anderson, S
Senville, J
Silver, M
Sebastiani, P
Terry, DF
Costa, PT
Perls, TT
AF Givens, Jane L.
Frederick, Maureen
Silverman, Leanne
Anderson, Stacy
Senville, Joanna
Silver, Margery
Sebastiani, Paola
Terry, Dellara F.
Costa, Paul T.
Perls, Thomas T.
TI Personality Traits of Centenarians' Offspring
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE personality; longevity; centenarian; extraversion; neuroticism;
agreeableness
ID ALL-CAUSE; MORTALITY; LONGEVITY; PREDICTORS
AB To determine whether the offspring of centenarians have personality characteristics that are distinct from the general population.
Case-control.
Nationwide U.S. sample.
Unrelated offspring of centenarians (n=246, mean age 75) were compared with published norms.
Using the NEO-Five-Factor Inventory (NEO-FFI) questionnaire, measures of the personality traits neuroticism, extraversion, openness, agreeableness, and conscientiousness were obtained. T-scores and percentiles were calculated according to sex and used to interpret the results.
Male and female offspring of centenarians scored in the low range of published norms for neuroticism and in the high range for extraversion. The women also scored comparatively high in agreeableness. Otherwise, both sexes scored within normal range for conscientiousness and openness, and the men scored within normal range for agreeableness.
Specific personality traits may be important to the relative successful aging demonstrated by the offspring of centenarians. Similarities across four of the five domains between male and female offspring is noteworthy and may relate to their successful aging. Measures of personality are an important phenotype to include in studies that assess genetic and environmental influences of longevity and successful aging.
C1 [Perls, Thomas T.] Boston Univ, Med Ctr, New England Centenarian Study, Geriatr Sect,Sch Med, Boston, MA 02118 USA.
[Silverman, Leanne; Costa, Paul T.] NIA, Lab Personal & Cognit, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.
[Silver, Margery] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA.
[Silver, Margery] Harvard Univ, Sch Med, Boston, MA USA.
[Sebastiani, Paola] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
RP Perls, TT (reprint author), Boston Univ, Med Ctr, New England Centenarian Study, Geriatr Sect,Sch Med, 88 E Newton St, Boston, MA 02118 USA.
EM thperls@bu.edu
OI Perls, Thomas/0000-0002-2492-4334; sebastiani,
paola/0000-0001-6419-1545; Costa, Paul/0000-0003-4375-1712
FU National Institute on Aging (NIA): [K-24, AG025727, K23 AG026754];
Beeson Physician Faculty Scholar in Aging Award; Intramural Research
Program of the NIA
FX Sponsor's Role: The sponsor, NIA, had no role in any of the above
activities.
NR 15
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U1 1
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-8614
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD APR
PY 2009
VL 57
IS 4
BP 683
EP 685
DI 10.1111/j.1532-5415.2009.02189.x
PG 3
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 428WT
UT WOS:000264883500015
PM 19392961
ER
PT J
AU Austin, HA
Illei, GG
Braun, MJ
Balow, JE
AF Austin, Howard A., III
Illei, Gabor G.
Braun, Michelle J.
Balow, James E.
TI Randomized, Controlled Trial of Prednisone, Cyclophosphamide, and
Cyclosporine in Lupus Membranous Nephropathy
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID 3 ETHNIC-GROUPS; MYCOPHENOLATE-MOFETIL; NEPHROTIC SYNDROME;
RETROSPECTIVE ANALYSIS; AFRICAN-AMERICANS; REVISED CRITERIA;
RISK-FACTORS; NEPHRITIS; ERYTHEMATOSUS; GLOMERULONEPHRITIS
AB Patients with lupus membranous nephropathy (LMN) are at substantial long-term risk for morbidity and mortality associated with protracted nephrotic syndrome, including ESRD. The optimal treatment for this condition is controversial. Forty-two patients with LMN participated in a randomized, controlled trial to compare adjunctive immunosuppressive drugs with prednisone alone. Adjunctive regimens included either cyclosporine (CsA) for 11 mo or alternate-month intravenous pulse cyclophosphamide (IVCY) for six doses; the control group received alternate-day prednisone alone. Median proteinuria was 5.4 g/d (range 2.7 to 15.4 g/d). We assessed the primary outcome, time to remission of proteinuria during the 12-mo protocol, by univariate survival analysis. At 1 yr, the cumulative probability of remission was 27% with prednisone, 60% with IVCY, and 83% with CsA. Although both IVCY and CsA were more effective than prednisone in inducing remissions of proteinuria, relapse of nephrotic syndrome occurred significantly more often after completion of CsA than after IVCY. By multivariate survival analysis, treatment with prednisone and high-grade proteinuria (> 5 g/d) but not race or ethnicity were independently associated with a decreased probability of remission. Adverse effects during the 12-mo protocol included insulin-requiring diabetes (one with prednisone and two with CsA), pneumonia (one with prednisone and two with CsA), and localized herpes zoster (two with IVCY). In conclusion, regimens containing CsA or IVCY are each more effective than prednisone alone in inducing remission of proteinuria among patients with LMN.
C1 [Austin, Howard A., III] NIDDK, NIH, Kidney Dis Sect, Bethesda, MD 20892 USA.
[Illei, Gabor G.] NIAMSD, NIH, Bethesda, MD 20892 USA.
[Illei, Gabor G.] Natl Inst Dent & Craniofacial Disorders, NIH, Bethesda, MD USA.
RP Austin, HA (reprint author), NIDDK, NIH, Kidney Dis Sect, Bldg 10,CRC 5-2551, Bethesda, MD 20892 USA.
EM howarda@bdg10.niddk.nih.gov
FU Intramural Research Program of the National Institute of Diabetes and
Digestive and Kidney Diseases, National Institutes of Health
FX This research was Supported by the Intramural Research Program of the
National Institute of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health.
NR 60
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U1 0
U2 9
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD APR
PY 2009
VL 20
IS 4
BP 901
EP 911
DI 10.1681/ASN.2008060665
PG 11
WC Urology & Nephrology
SC Urology & Nephrology
GA 428ER
UT WOS:000264831300028
PM 19297556
ER
PT J
AU Greenberg, SJ
Gallagher, PE
AF Greenberg, Stephen J.
Gallagher, Patricia E.
TI The great contribution: Index Medicus, Index-Catalogue, and IndexCat
SO JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION
LA English
DT Article
AB Objective: The systematic indexing of medical literature by the Library of the Surgeon-General's Office (now the National Library of Medicine) has been called "America's greatest contribution to medical knowledge.'' In the 1870s, the library launched two indexes: the Index Medicus and the Index-Catalogue of the Library of the Surgeon-General's Office. Index Medicus is better remembered today as the forerunner of MEDLINE, but Index Medicus began as the junior partner of what the library saw as its major publication, the Index-Catalogue. However, the Index-Catalogue had been largely overlooked by many medical librarians until 2004, when the National Library of Medicine released IndexCat, the online version of Index-Catalogue. Access to this huge amount of material raised new questions: What was the coverage of the Index-Catalogue? How did it compare and overlap with the Index Medicus?
Method: Over 1,000 randomly generated Index Medicus citations were cross-referenced in IndexCat.
Results: Inclusion, form, content, authority control, and subject headings were evaluated, revealing that the relationship between the two publications was neither simple nor static through time. In addition, the authors found interesting anomalies that shed light on how medical literature was selected and indexed in "America's greatest contribution to medical knowledge.''
C1 [Greenberg, Stephen J.] Natl Lib Med, Hist Med Div, Bethesda, MD 20894 USA.
[Gallagher, Patricia E.] New York Acad Med, New York, NY 10029 USA.
RP Greenberg, SJ (reprint author), Natl Lib Med, Hist Med Div, 8600 Rockville Pike, Bethesda, MD 20894 USA.
EM greenbes@mail.nih.gov; pgallagher@nyam.org
NR 10
TC 0
Z9 0
U1 0
U2 1
PU MEDICAL LIBRARY ASSOC
PI CHICAGO
PA 65 EAST WACKER PLACE, STE 1900, CHICAGO, IL 60601-7298 USA
SN 1536-5050
J9 J MED LIBR ASSOC
JI J. Med. Libr. Assoc.
PD APR
PY 2009
VL 97
IS 2
BP 108
EP 113
DI 10.3163/1536-5050.97.2.007
PG 6
WC Information Science & Library Science
SC Information Science & Library Science
GA 470TK
UT WOS:000268003100009
PM 19404501
ER
PT J
AU Wheeler, CM
Hunt, WC
Joste, NE
Key, CR
Quint, WGV
Castle, PE
AF Wheeler, Cosette M.
Hunt, William C.
Joste, Nancy E.
Key, Charles R.
Quint, Wim G. V.
Castle, Philip E.
TI Human Papillomavirus Genotype Distributions: Implications for
Vaccination and Cancer Screening in the United States
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID SQUAMOUS-CELL CARCINOMAS; INVASIVE CERVICAL-CANCER; INTRAEPITHELIAL
NEOPLASIA GRADE-2; LINE PROBE ASSAY; UTERINE CERVIX; PARTICLE VACCINE;
HPV INFECTION; RISK-FACTORS; BLOT ASSAY; WOMEN
AB Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.
We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and invasive (n = 808) cervical cancer diagnosed during 1985-1999 and 1980-1999, respectively, in the state of New Mexico. HPV genotyping was performed using two polymerase chain reaction-based methods on paraffin-embedded tissues from in situ and invasive cancers and on cervical Papanicolaou test specimen from control subjects (ie, women aged 18-40 years attending clinics for routine cervical screening [n = 4007]). Relative risks for cervical cancer were estimated, and factors associated with age at cancer diagnosis and the prevalence of HPV genotypes in cancers were examined.
The most common HPV genotypes detected in invasive cancers were HPV type 16 (HPV16, 53.2%), HPV18 (13.1%), and HPV45 (6.1%) and those in in situ cancers were HPV16 (56.3%), HPV31 (12.6%), and HPV33 (8.0%). Invasive cancer case subjects who were positive for HPV16 or 18 were diagnosed at younger ages than those who were positive for other carcinogenic HPV genotypes (mean age at diagnosis: 48.1 [95% confidence interval {CI} = 46.6 to 49.6 years], 45.9 [95% CI = 42.9 to 49.0 years], and 52.3 years [95% CI = 50.0 to 54.6 years], respectively). The proportion of HPV16-positive in situ and invasive cancers, but not of HPV18-positive cancers, declined with more recent calendar year of diagnosis, whereas the proportion positive for carcinogenic HPV genotypes other than HPV18 increased.
HPV16 and 18 caused the majority of invasive cervical cancer in this population sample of US women, but the proportion attributable to HPV16 declined over the last 20 years. The age at diagnosis of HPV16- and HPV18-related cancers was 5 years earlier than that of cancers caused by carcinogenic HPV genotypes other than HPV16 and 18, suggesting that the age at initiation of cervical screening could be delayed in HPV-vaccinated populations.
C1 [Wheeler, Cosette M.; Hunt, William C.] Univ New Mexico, Sch Med, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA.
[Wheeler, Cosette M.] Univ New Mexico, Sch Med, Hlth Sci Ctr, Dept Obstet & Gynecol, Albuquerque, NM 87131 USA.
[Joste, Nancy E.; Key, Charles R.] Univ New Mexico, Sch Med, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA.
[Key, Charles R.] Univ New Mexico, Sch Med, Hlth Sci Ctr, New Mexico Tumor Registry, Albuquerque, NM 87131 USA.
[Quint, Wim G. V.] DDL Diagnost Lab, Voorburg, Netherlands.
[Castle, Philip E.] NCI, Div Canc Epidemiol & Genet, Natl Inst Hlth, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
RP Wheeler, CM (reprint author), Univ New Mexico, Sch Med, Hlth Sci Ctr, Dept Mol Genet & Microbiol, House Prevent Epidemiol,1816 Sigma Chi Rd Bldg 19, Albuquerque, NM 87131 USA.
EM cwheeler@salud.unm.edu
FU US National Institutes of Allergy and Infectious Diseases [AI32917]; US
National Cancer Institute; University of New Mexico; Merck Research
Laboratories (West Point, PA); GlaxoSmithKline Biologicals (King of
Prussia, PA); Roche Molecular Systems (Alameda, CA); GlaxoSmith Kline;
National Cancer Institute; National Institutes of Health
FX This work was funded by a grant to C. M. Wheeler (AI32917) from the US
National Institutes of Allergy and Infectious Diseases and the US
National Cancer Institute. C. M. Wheeler has received research support
through the University of New Mexico for vaccine clinical trials from
Merck Research Laboratories (West Point, PA) and GlaxoSmithKline
Biologicals (King of Prussia, PA) and for HPV genotyping from Roche
Molecular Systems (Alameda, CA). W. G. V. Quint has received research
support from GlaxoSmith Kline. This research (P. E. Castle) is supported
(in part) by the Intramural Research Program of the National Cancer
Institute, National Institutes of Health.
NR 51
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U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD APR 1
PY 2009
VL 101
IS 7
BP 475
EP 487
DI 10.1093/jnci/djn510
PG 13
WC Oncology
SC Oncology
GA 428ZP
UT WOS:000264890900008
PM 19318628
ER
PT J
AU Qiao, YL
Dawsey, SM
Kamangar, F
Fan, JH
Abnet, CC
Sun, XD
Johnson, LL
Gail, MH
Dong, ZW
Yu, B
Mark, SD
Taylor, PR
AF Qiao, You-Lin
Dawsey, Sanford M.
Kamangar, Farin
Fan, Jin-Hu
Abnet, Christian C.
Sun, Xiu-Di
Johnson, Laura Lee
Gail, Mitchell H.
Dong, Zhi-Wei
Yu, Binbing
Mark, Steven D.
Taylor, Philip R.
TI Total and Cancer Mortality After Supplementation With Vitamins and
Minerals: Follow-up of the Linxian General Population Nutrition
Intervention Trial
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID PRIMARY LIVER-CANCER; RANDOMIZED CONTROLLED-TRIAL; DISEASE-SPECIFIC
MORTALITY; BETA-CAROTENE SUPPLEMENTS; BASE-LINE CHARACTERISTICS; RETINOL
EFFICACY TRIAL; GASTRIC-CARDIA CANCER; LUNG-CANCER;
CARDIOVASCULAR-DISEASE; ALPHA-TOCOPHEROL
AB The General Population Nutrition Intervention Trial was a randomized primary esophageal and gastric cancer prevention trial conducted from 1985 to 1991, in which 29 584 adult participants in Linxian, China, were given daily vitamin and mineral supplements. Treatment with "factor D," a combination of 50 mu g selenium, 30 mg vitamin E, and 15 mg beta-carotene, led to decreased mortality from all causes, cancer overall, and gastric cancer. Here, we present 10-year follow-up after the end of active intervention.
Participants were assessed by periodic data collection, monthly visits by village health workers, and quarterly review of the Linxian Cancer Registry. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the cumulative effects of four vitamin and mineral supplementation regimens were calculated using adjusted proportional hazards models.
Through May 31, 2001, 276 participants were lost to follow-up; 9727 died, including 3242 from cancer (1515 from esophageal cancer and 1199 from gastric cancer). Participants who received factor D had lower overall mortality (HR = 0.95, 95% CI = 0.91 to 0.99; P = .009; reduction in cumulative mortality from 33.62% to 32.19%) and gastric cancer mortality (HR = 0.89, 95% CI = 0.79 to 1.00; P = .043; reduction in cumulative gastric cancer mortality from 4.28% to 3.84%) than subjects who did not receive factor D. Reductions were mostly attributable to benefits to subjects younger than 55 years. Esophageal cancer deaths between those who did and did not receive factor D were not different overall; however, decreased 17% among participants younger than 55 (HR = 0.83, 95% CI = 0.71 to 0.98; P = .025) but increased 14% among those aged 55 years or older (HR = 1.14, 95% CI = 1.00 to 1.30; P = .47). Vitamin A and zinc supplementation was associated with increased total and stroke mortality; vitamin C and molybdenum supplementation, with decreased stroke mortality.
The beneficial effects of selenium, vitamin E, and beta-carotene on mortality were still evident up to 10 years after the cessation of supplementation and were consistently greater in younger participants. Late effects of other supplementation regimens were also observed.
C1 [Taylor, Philip R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Natl Inst Hlth, Bethesda, MD 20892 USA.
[Qiao, You-Lin; Fan, Jin-Hu; Sun, Xiu-Di; Dong, Zhi-Wei] Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China.
[Johnson, Laura Lee] Natl Ctr Complementary & Alternat Med, Bethesda, MD USA.
[Yu, Binbing] Informat Management Serv Inc, Silver Spring, MD USA.
RP Taylor, PR (reprint author), NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Natl Inst Hlth, 6120 Execut Blvd,Rm 7006,MSC 7236, Bethesda, MD 20892 USA.
EM ptaylor@mail.nih.gov
RI Qiao, You-Lin/B-4139-2012; Abnet, Christian/C-4111-2015
OI Qiao, You-Lin/0000-0001-6380-0871; Abnet, Christian/0000-0002-3008-7843
FU National Cancer Institute [N01-SC-91030, N01-RC-47701]; Cancer
Institute, Chinese Academy of Medical Sciences; Division of Cancer
Epidemiology and Genetics; National Cancer Institute; National
Institutes of Health
FX National Cancer Institute contracts (N01-SC-91030 and N01-RC-47701 to
the Cancer Institute, Chinese Academy of Medical Sciences); the
Intramural Research Program of the Division of Cancer Epidemiology and
Genetics, National Cancer Institute, National Institutes of Health; the
Cancer Institute, Chinese Academy of Medical Sciences.
NR 50
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U1 3
U2 22
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD APR 1
PY 2009
VL 101
IS 7
BP 507
EP 518
DI 10.1093/jnci/djp037
PG 12
WC Oncology
SC Oncology
GA 428ZP
UT WOS:000264890900011
PM 19318634
ER
PT J
AU Howlader, N
Ries, LA
Stinchcomb, DG
Edwards, BK
AF Howlader, Nadia
Ries, Lynn A.
Stinchcomb, David G.
Edwards, Brenda K.
TI The Impact of Underreported Veterans Affairs Data on National Cancer
Statistics: Analysis Using Population-Based SEER Registries
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID RATES
AB Reduced cancer reporting by the US Department of Veterans Affairs (VA) hospitals in 2007 (for patients diagnosed through 2005) impacted the most recent US cancer surveillance data. To quantify the impact of the reduced VA reporting on cancer incidence and trends produced by the Surveillance, Epidemiology, and End Results Program, we estimated numbers of missing VA patients in 2005 by sex, age, race, selected cancer sites, and registry and calculated adjustment factors to correct for the 2005 incidence rates and trends. Based on our adjustment factors, we estimated that as a result of the underreporting, the overall cancer burden was underestimated by 1.6% for males and 0.05% for females. For males, the percentage of patients missing ranged from 2.5% for liver cancer to 0.4% for melanoma of the skin. For age-adjusted male overall cancer incidence rates, the adjustment factors were 1.015, 1.012, and 1.035 for all races, white males, and black males, respectively. Modest changes in long-term incidence trends were observed, particularly in black males.
C1 [Howlader, Nadia; Ries, Lynn A.; Stinchcomb, David G.; Edwards, Brenda K.] NCI, Div Canc Control & Populat Sci, Canc Stat Branch, Surveillance Res Program, Rockville, MD USA.
RP Howlader, N (reprint author), NCI, Canc Surveillance Branch, Div Canc Control & Populat Sci, 6116 Execut Blvd,Suite 504, Bethesda, MD 20892 USA.
EM howladern@mail.nih.gov
FU Division of Cancer Control and Population Sciences; Surveillance
Research Program; National Cancer Institute; National Institutes of
Health
FX Division of Cancer Control and Population Sciences, Surveillance
Research Program, National Cancer Institute, National Institutes of
Health to BK Edwards.
NR 6
TC 25
Z9 25
U1 1
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD APR 1
PY 2009
VL 101
IS 7
BP 533
EP 536
DI 10.1093/jnci/djn517
PG 4
WC Oncology
SC Oncology
GA 428ZP
UT WOS:000264890900013
PM 19318639
ER
PT J
AU Traynor, AM
Dubey, S
Eickhoff, JC
Kolesar, JM
Schell, K
Huie, MS
Groteluschen, DL
Marcotte, SM
Hallahan, CM
Weeks, HR
Wilding, G
Espinoza-Delgado, I
Schiller, JH
AF Traynor, Anne M.
Dubey, Sarita
Eickhoff, Jens C.
Kolesar, Jill M.
Schell, Kathleen
Huie, Michael S.
Groteluschen, David L.
Marcotte, Sarah M.
Hallahan, Courtney M.
Weeks, Hilary R.
Wilding, George
Espinoza-Delgado, Igor
Schiller, Joan H.
TI Vorinostat (NSC# 701852) in Patients with Relapsed Non-small Cell Lung
Cancer A Wisconsin Oncology Network Phase II Study
SO JOURNAL OF THORACIC ONCOLOGY
LA English
DT Article
DE Non-small cell lung cancer; Relapsed disease; Histone deacetylase
inhibitors; Phase II
ID HISTONE DEACETYLASE INHIBITORS; SUBEROYLANILIDE HYDROXAMIC ACID;
CLINICAL-EXPERIENCE; POTENTIAL ROLE; TRIAL; APOPTOSIS; COMBINATION;
CARCINOMA; LYMPHOMA; SAHA
AB Introduction: Vorinostat is a small molecule inhibitor of historic deacetylase, and has shown preclinical activity in non-small cell lung cancer (NSCLC).
Methods: Patients with relapsed NSCLC were eligible. Patients received oral vorinostat, 400 mg daily. The primary objective was response rate, with the goal of at least one responder in the first 14 evaluable patients, according to the two-stage minimax design. Secondary objectives included time to progression (TTP), overall survival (OS), and safety.
Results: Sixteen patients enrolled from January 2006 to April 2007. The median age was 59.5 years. Thirteen patients were female. Two patients were not evaluable for response due to progressive disease within Cycle 1. No objective antitumor responses were seen in the 14 evaluable patients. Eight patients experienced stable disease (median 3.7 months, range 1.4-19.4). Median TTP was 2.3 months (range 0.9-19.4 months), median OS was 7.1 months (range 1.4-30.0+ months), and estimated I year OS rate was 19% (SE 10%). One patient died on Study from an acute ischemic stroke; this event was deemed possibly related to treatment. Grade 3/4 adverse events possibly related to vorinostat included neutropenia, lymphopenia, fatigue, pulmonary embolus/deep vein thrombosis, dehydration, elevated alkaline phosphatase, and hypokalemia.
Conclusions: No objective antitumor activity was detected with single agent vorinostat in this setting; however, it yields TTP in relapsed NSCLC similar to that of other targeted agents. Further Studies in NSCLC should focus on combining vorinostat with other antitumor agents.
C1 [Traynor, Anne M.; Eickhoff, Jens C.; Kolesar, Jill M.; Schell, Kathleen; Huie, Michael S.; Marcotte, Sarah M.; Hallahan, Courtney M.; Weeks, Hilary R.; Wilding, George] Univ Wisconsin, Sch Med & Publ Hlth, Paul P Carbone Comprehens Canc Ctr, Madison, WI USA.
[Dubey, Sarita] Univ Calif San Francisco, Sch Med, Ctr Canc, San Francisco, CA USA.
[Groteluschen, David L.] Green Bay Oncol, Green Bay, WI USA.
[Espinoza-Delgado, Igor] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
[Schiller, Joan H.] Univ Texas SW Med Ctr Dallas, Div Hematol & Oncol, Dept Internal Med, Dallas, TX 75390 USA.
RP Traynor, AM (reprint author), K6-568 CSC 5669,600 Highland Ave, Madison, WI 53792 USA.
EM amt@medicine.wisc.edu
FU University of Wisconsin Paul P. Carbone Comprehensive Cancer Center [K12
CA087716]; NCI [01 CA062491, UWCCC 2 P30 CA014520-34]; NCI/CTEP
[24XS097]
FX The authors thank our patients, their families, and our clinic staff in
the completion of this trial, as well as the UWCCC Analytical
Instrumentation Laboratory for Pharmacokinetics, Pharmacodynamics, and
Pharmacogenetics for support of this research.
NR 40
TC 69
Z9 72
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1556-0864
J9 J THORAC ONCOL
JI J. Thorac. Oncol.
PD APR
PY 2009
VL 4
IS 4
BP 522
EP 526
PG 5
WC Oncology; Respiratory System
SC Oncology; Respiratory System
GA 425BD
UT WOS:000264611100014
PM 19347984
ER
PT J
AU Schaeffer, EM
Carter, HB
Kettermann, A
Loeb, S
Ferrucci, L
Landis, P
Trock, BJ
Metter, EJ
AF Schaeffer, Edward M.
Carter, H. Ballentine
Kettermann, Anna
Loeb, Stacy
Ferrucci, Luigi
Landis, Patricia
Trock, Bruce J.
Metter, E. Jeffrey
TI Prostate Specific Antigen Testing Among the Elderly-When To Stop?
SO JOURNAL OF UROLOGY
LA English
DT Article
DE prostate-specific antigen; early detection of cancer; prostatic
neoplasms; aged
ID UNITED-STATES; CANCER; MEN; MANAGEMENT
AB Purpose: Prostate specific antigen testing is common in the elderly despite evidence that older men without aggressive prostate cancer are unlikely to benefit from diagnosis and treatment. We evaluated the relationship between prostate specific antigen and the risk of aggressive prostate cancer developing in men of various ages.
Materials and Methods: This longitudinal cohort study consisted of 849 men (122 with and 727 without prostate cancer) with serial prostate specific antigen measurements participating in the Baltimore Longitudinal Study of Aging. The primary outcome measure was the proportion of men by prostate specific antigen and age who died of prostate cancer or in whom aggressive prostate cancer developed (death from prostate cancer, a prostate specific antigen 20 ng/ml or greater, or Gleason score 8 or greater).
Results: No participants between 75 and 80 years old with a prostate specific antigen less than 3.0 ng/ml died of prostate cancer. In contrast, men of all ages with a prostate specific antigen of 3.0 ng/ml or greater had a continually increasing probability of death from prostate cancer (Fisher's exact test p <0.001). The time to death or diagnosis of aggressive prostate cancer after age 75 years was not significantly different between the prostate specific antigen categories of 3 to 3.9 and 4 to 9.9 ng/ml (p = 0.634), whereas the time to death or diagnosis of high risk prostate cancer was significantly longer for the prostate specific antigen category of less than 3 vs 3 ng/ml or greater (p = 0.019).
Conclusions: Men 75 to 80 years old with a prostate specific antigen less than 3 ng/ml are unlikely to die of or experience aggressive prostate cancer during their remaining life, suggesting that prostate specific antigen testing might be safely discontinued for these men.
C1 [Schaeffer, Edward M.; Carter, H. Ballentine; Kettermann, Anna; Loeb, Stacy; Landis, Patricia; Trock, Bruce J.] Johns Hopkins Univ, Sch Med, Dept Urol, James Buchanan Brady Urol Inst,Johns Hopkins Hosp, Baltimore, MD 21205 USA.
[Ferrucci, Luigi; Metter, E. Jeffrey] NIA, Clin Res Branch, Natl Inst Hlth, Baltimore, MD 21224 USA.
RP Schaeffer, EM (reprint author), Johns Hopkins Sch Med, Dept Urol, Marburg 134,600 N Wolfe St, Baltimore, MD 21287 USA.
EM eschaeffer@jhmi.edu
OI Loeb, Stacy/0000-0003-3933-9207
FU National Institutes of Health
FX Supported by the Intramural Research Program of the National Institutes
of Health, National Institute on Aging.
NR 20
TC 40
Z9 41
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD APR
PY 2009
VL 181
IS 4
BP 1606
EP 1613
DI 10.1016/j.juro.2008.11.117
PG 8
WC Urology & Nephrology
SC Urology & Nephrology
GA 422SO
UT WOS:000264448200028
PM 19246059
ER
PT J
AU Pinsky, PF
AF Pinsky, Paul F.
TI 15-Year Followup of a Population Based Prostate Cancer Screening Study
COMMENT
SO JOURNAL OF UROLOGY
LA English
DT Editorial Material
C1 Natl Canc Inst, Bethesda, MD USA.
RP Pinsky, PF (reprint author), Natl Canc Inst, Bethesda, MD USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD APR
PY 2009
VL 181
IS 4
BP 1621
EP 1621
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 422SO
UT WOS:000264448200033
ER
PT J
AU Kramer, BS
Hagerty, KL
Justman, S
Somerfield, MR
Albertsen, PC
Blot, WJ
Carter, HB
Costantino, JP
Epstein, JI
Godley, PA
Harris, RP
Wilt, TJ
Wittes, J
Zon, R
Schellhammer, P
AF Kramer, Barnett S.
Hagerty, Karen L.
Justman, Stewart
Somerfield, Mark R.
Albertsen, Peter C.
Blot, William J.
Carter, H. Ballentine
Costantino, Joseph P.
Epstein, Jonathan I.
Godley, Paul A.
Harris, Russell P.
Wilt, Timothy J.
Wittes, Janet
Zon, Robin
Schellhammer, Paul
TI Use of 5 alpha-Reductase Inhibitors for Prostate Cancer Chemoprevention:
American Society of Clinical Oncology/American Urological Association
2008 Clinical Practice Guideline
SO JOURNAL OF UROLOGY
LA English
DT Article
ID URINARY-TRACT SYMPTOMS; RANDOMIZED CONTROLLED-TRIAL; SURGICAL ADJUVANT
BREAST; BOWEL PROJECT P-1; PREVENTION TRIAL; COMBINATION THERAPY;
FINASTERIDE THERAPY; MODELING APPROACH; HYPERPLASIA; MEN
AB Purpose: To develop an evidence-based guideline on the use of 5-alpha-reductase inhibitors (5-ARIs) for prostate cancer chemoprevention.
Methods: The American Society of Clinical Oncology (ASCO) Health Services Committee (HSC), ASCO Cancer Prevention Committee, and the American Urological Association Practice Guidelines Committee jointly convened a Panel of experts, who used the results from a systematic review of the literature to develop evidence-based recommendations on the use of 5-ARIs for prostate cancer chemoprevention.
Results: The systematic review completed for this guideline identified 15 randomized clinical trials that met the inclusion criteria; nine of which reported prostate cancer period prevalence.
Conclusion: Asymptomatic men with a prostate-specific antigen (PSA) <= 3.0 ng/mL who are regularly screened with PSA or are anticipating undergoing annual PSA screening for early detection of prostate cancer may benefit from a discussion of both the benefits of 5-ARIs for 7 years for the prevention of prostate cancer and the potential risks (including the possibility of high-grade prostate cancer). Men who are taking 5-ARIs for benign conditions such as lower urinary tract [obstructive] symptoms (LUTS) may benefit from a similar discussion, understanding that the improvement of LUTS relief should be weighed with the potential risks of high-grade prostate cancer from 5-ARIs (although the majority of the Panel members judged the latter risk to be unlikely). A reduction of approximately 50% in PSA by 12 months is expected in men taking a 5-ARI; however, because these changes in PSA may vary across men, and within individual men over time, the Panel cannot recommend a specific cut point to trigger a biopsy for men taking a 5-ARI. No specific cut point or change in PSA has been prospectively validated in men taking a 5-ARI.
C1 [Kramer, Barnett S.] Natl Inst Hlth, Bethesda, MD USA.
Amer Soc Clin Oncol, Alexandria, VA USA.
Univ Montana Liberal Studies, Missoula, MT USA.
Univ Connecticut Hlth Ctr, Farmington, CT USA.
Int Epidemiol Inst, Rockville, MD USA.
Johns Hopkins Univ, Baltimore, MD USA.
Natl Surg Adjuvant Breast & Bowel Project, Pittsburgh, PA USA.
Univ N Carolina, Chapel Hill, NC USA.
Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
Stat Collaborat, Washington, DC USA.
Michiana Hematol Oncol, Granger, IN USA.
Eastern Virginia Med Sch, Norfolk, VA 23501 USA.
RP Kramer, BS (reprint author), Natl Inst Hlth, Bethesda, MD USA.
FU GlaxoSmithKline; Merck; Theralogix; Dendreon Corporation; Southwestern
Oncology Group; ContraVac
FX Financial interest and/or other relationship with Theralogix, Dendreon
Corporation, Southwestern Oncology Group and ContraVac.
NR 53
TC 33
Z9 35
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD APR
PY 2009
VL 181
IS 4
BP 1642
EP 1657
DI 10.1016/j.juro.2009.01.071
PG 16
WC Urology & Nephrology
SC Urology & Nephrology
GA 422SO
UT WOS:000264448200040
PM 19249063
ER
PT J
AU Moore, SC
Peters, TM
Ahn, J
Park, Y
Schatzkin, A
Albanes, D
Ballard-Barbash, R
Hollenbeck, A
Leitzmann, MF
AF Moore, S. C.
Peters, T. M.
Ahn, J.
Park, Y.
Schatzkin, A.
Albanes, D.
Ballard-Barbash, R.
Hollenbeck, A.
Leitzmann, M. F.
TI Physical Activity in Relation to Total, Advanced, and Fatal Prostate
Cancer
SO JOURNAL OF UROLOGY
LA English
DT Editorial Material
C1 [Moore, S. C.; Peters, T. M.; Ahn, J.; Park, Y.; Schatzkin, A.; Albanes, D.; Ballard-Barbash, R.; Hollenbeck, A.; Leitzmann, M. F.] NCI, Div Canc Epidemiol, Bethesda, MD 20892 USA.
RP Moore, SC (reprint author), NCI, Div Canc Epidemiol, Bethesda, MD 20892 USA.
RI Albanes, Demetrius/B-9749-2015
NR 1
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD APR
PY 2009
VL 181
IS 4
BP 1688
EP 1688
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 422SO
UT WOS:000264448200052
ER
PT J
AU Biancotto, A
Brichacek, B
Chen, SS
Fitzgerald, W
Lisco, A
Vanpouille, C
Margolis, L
Grivel, JC
AF Biancotto, Angelique
Brichacek, Beda
Chen, Silvia S.
Fitzgerald, Wendy
Lisco, Andrea
Vanpouille, Christophe
Margolis, Leonid
Grivel, Jean-Charles
TI A highly sensitive and dynamic immunofluorescent cytometric bead assay
for the detection of HIV-1 p24
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE HIV-1; p24; Detection; Multiplex assay; Diagnosis
ID VIRUS TYPE-1 RNA; ANTIGEN-ASSAY; PLASMA; ANTIBODIES; INFECTION;
SPECIMENS
AB Nucleic acid measurements are used to follow HIV-1 viral load in clinical applications while p24 ELISA is commonly used to monitor HIV-1 replication in research settings. Current ELISA assays are expensive and offer a narrow dynamic measurement range. This report describes a simple, sensitive and inexpensive bead-based assay offering a wide dynamic measurement range. This cytometric bead assay allows the detection of p24 concentrations over 4 orders of magnitude from less than 0.4 pg to up to 20,000 pg ml(-1) in a volume of 50 mu l and can be combined with other measurements. Published by Elsevier B.V.
C1 [Biancotto, Angelique; Brichacek, Beda; Chen, Silvia S.; Fitzgerald, Wendy; Lisco, Andrea; Vanpouille, Christophe; Margolis, Leonid; Grivel, Jean-Charles] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Intercellular Interact, Program Phys Biol, Bethesda, MD 20892 USA.
RP Grivel, JC (reprint author), NICHHD, Cellular & Mol Biol Lab, NIH, Bldg 10,Rm 9D58, Bethesda, MD 20892 USA.
EM grivelj@mail.nih.gov
FU Intramural NIH HHS [Z01 HD001416-15]
NR 15
TC 25
Z9 26
U1 1
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD APR
PY 2009
VL 157
IS 1
BP 98
EP 101
DI 10.1016/j.jviromet.2008.11.013
PG 4
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 425VY
UT WOS:000264667000015
PM 19100289
ER
PT J
AU Ruckwardt, TJ
Bonaparte, KL
Nason, MC
Graham, BS
AF Ruckwardt, Tracy J.
Bonaparte, Kathryn L.
Nason, Martha C.
Graham, Barney S.
TI Regulatory T Cells Promote Early Influx of CD8(+) T Cells in the Lungs
of Respiratory Syncytial Virus-Infected Mice and Diminish
Immunodominance Disparities
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID RESPONSES; DISEASE; MEMORY; EPITOPE; PATHOGENESIS; DEPLETION; IMMUNITY;
INFANTS; ILLNESS; LAVAGE
AB In addition to regulating autoimmunity and antitumor immunity, CD4(+) CD25(+) FoxP3(+) natural regulatory T (Treg) cells are global regulators of adaptive immune responses. Depletion of these cells with the anti-CD25 antibody PC61 prior to primary respiratory syncytial virus (RSV) infection was partial but had several effects on the RSV-specific CD8(+) response in a hybrid mouse model. Mediastinal lymph node and spleen epitope-specific CD8(+) T-cell responses were enhanced in Treg-cell-depleted mice at all time points following infection, but responses of Treg-cell-depleted lung show a strikingly different pattern than lymphoid organ responses, with an initial delay in the CD8(+) T-cell response. The delay in the CD8(+) T-cell response correlated with a delay both in the early phase of viral clearance and in illness in Treg-cell-depleted mice compared to isotype-treated controls. The lungs of Treg-cell-depleted mice were shown to have increased lung chemokine and cytokine levels 7 days postinfection despite lower CD8(+) T-cell responses. Following the early delay in the lung response, CD8(+) T-cell responses at later infection time points were enhanced and increased the severity of illness in depleted mice. Finally, decreasing regulatory T-cell control of the CD8(+) T-cell response had a greater effect on response of the dominant K-d-restricted M2 epitope consisting of amino acids 82 to 90 (K(d)M2(82-90)) than on the subdominant (DM187-195)-M-b epitope response, indicating that regulatory T cells modulate immunodominance disparities in epitope-specific CD8(+) T-cell responses following primary RSV infection.
C1 [Ruckwardt, Tracy J.; Bonaparte, Kathryn L.; Graham, Barney S.] NIAID, Viral Pathogenesis Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Nason, Martha C.] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA.
RP Graham, BS (reprint author), NIAID, Viral Pathogenesis Lab, Vaccine Res Ctr, NIH, 40 Convent Dr, Bethesda, MD 20892 USA.
EM bgraham@nih.gov
FU National Institute of Allergy and Infectious Diseases
FX This work was supported by intramural funding through the National
Institute of Allergy and Infectious Diseases.; Reagents for initial
experiments were provided by the NIH Tetramer Core Facility, Emory
University, Atlanta, GA.
NR 42
TC 67
Z9 68
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2009
VL 83
IS 7
BP 3019
EP 3028
DI 10.1128/JVI.00036-09
PG 10
WC Virology
SC Virology
GA 417AE
UT WOS:000264046000021
PM 19153229
ER
PT J
AU Aoki, M
Venzon, DJ
Koh, Y
Aoki-Ogata, H
Miyakawa, T
Yoshimura, K
Maeda, K
Mitsuya, H
AF Aoki, Manabu
Venzon, David J.
Koh, Yasuhiro
Aoki-Ogata, Hiromi
Miyakawa, Toshikazu
Yoshimura, Kazuhisa
Maeda, Kenji
Mitsuya, Hiroaki
TI Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human
Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid
Acquisition of Amprenavir Resistance but Delay Development of Resistance
to Other Protease Inhibitors
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID ACTIVE ANTIRETROVIRAL THERAPY; IN-VITRO SELECTION; VIRAL FITNESS;
REVERSE-TRANSCRIPTASE; NELFINAVIR-RESISTANT; POSITIVE PATIENTS;
DRUG-RESISTANCE; MATRIX PROTEIN; REPLICATION; VARIANTS
AB In an attempt to determine whether mutations in Gag in human immunodeficiency virus type 1 (HIV-1) variants selected with a protease inhibitor (PI) affect the development of resistance to the same or a different PI(s), we generated multiple infectious HIV-1 clones carrying mutated Gag and/or mutated protease proteins that were identified in amprenavir (APV)-selected HIV-1 variants and examined their virological characteristics. In an HIV-1 preparation selected with APV (33 passages, yielding HIV(APVp33)), we identified six mutations in protease and six apparently critical mutations at cleavage and non-cleavage sites in Gag. An infectious recombinant clone carrying the six protease mutations but no Gag mutations failed to replicate, indicating that the Gag mutations were required for the replication of HIV(APVp33). An infectious recombinant clone that carried wild-type protease and a set of five Gag mutations (rHIV(WTpro)(12/75/219/390/409gag)) replicated comparably to wild-type HIV-1; however, when exposed to APV, rHIV(WTpro)(12/75/219/390/409gag) rapidly acquired APV resistance. In contrast, the five Gag mutations significantly delayed the acquisition of HIV-1 resistance to ritonavir and nelfinavir (NFV). Recombinant HIV-1 clones containing NFV resistance-associated mutations, such as D30N and N88S, had increased susceptibilities to APV, suggesting that antiretroviral regimens including both APV and NFV may bring about favorable antiviral efficacy. The present data suggest that the preexistence of certain Gag mutations related to PI resistance can accelerate the emergence of resistance to the PI and delay the acquisition of HIV resistance to other PIs, and these findings should have clinical relevance in the therapy of HIV-1 infection with PI-including regimens.
C1 [Aoki, Manabu; Koh, Yasuhiro; Aoki-Ogata, Hiromi; Miyakawa, Toshikazu; Yoshimura, Kazuhisa; Maeda, Kenji; Mitsuya, Hiroaki] Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Dept Hematol, Kumamoto 8608556, Japan.
[Aoki, Manabu; Koh, Yasuhiro; Aoki-Ogata, Hiromi; Miyakawa, Toshikazu; Yoshimura, Kazuhisa; Maeda, Kenji; Mitsuya, Hiroaki] Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Dept Infect Dis, Kumamoto 8608556, Japan.
[Aoki, Manabu] Kumamoto Hlth Sci Univ, Inst Hlth Sci, Kumamoto 8615598, Japan.
[Venzon, David J.] NCI, Biostat & Data Management Sect, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Maeda, Kenji; Mitsuya, Hiroaki] NCI, Expt Retrovirol Sect, HIV & AIDS Malignancy Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
RP Mitsuya, H (reprint author), Kumamoto Univ, Sch Med, Dept Hematol, 1-1-1 Honjo, Kumamoto 8608556, Japan.
EM hm21q@nih.gov
FU Ministry of Education, Culture, Sports, Science, and Technology of
Japan; Ministry of Health, Welfare, and Labor of Japan [H15-AIDS001];
Institute of Health Sciences, Kumamoto Health Science University; Center
for Cancer Research; National Cancer Institute; National Institutes of
Health
FX This work was supported in part by a grant-in-aid for scientific
research (priority areas) from the Ministry of Education, Culture,
Sports, Science, and Technology of Japan (Monbu-Kagakusho); a grant to
the Cooperative Research Project on Clinical and Epidemiological Studies
of Emerging and Reemerging Infectious Diseases (Renkei Jigyo; no. 78,
Kumamoto University) of Monbu-Kagakusho (H. M.); a grant for the
promotion of AIDS research from the Ministry of Health, Welfare, and
Labor of Japan (Kosei-Rohdosho; H15-AIDS001); a grant-in-aid from the
Institute of Health Sciences, Kumamoto Health Science University (M.
A.); and in part by the intramural research program of the Center for
Cancer Research, National Cancer Institute, National Institutes of
Health.
NR 49
TC 16
Z9 16
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2009
VL 83
IS 7
BP 3059
EP 3068
DI 10.1128/JVI.02539-08
PG 10
WC Virology
SC Virology
GA 417AE
UT WOS:000264046000025
PM 19176623
ER
PT J
AU Chaipan, C
Kobasa, D
Bertram, S
Glowacka, I
Steffen, I
Tsegaye, TS
Takeda, M
Bugge, TH
Kim, S
Park, Y
Marzi, A
Pohlmann, S
AF Chaipan, Chawaree
Kobasa, Darwyn
Bertram, Stephanie
Glowacka, Ilona
Steffen, Imke
Tsegaye, Theodros Solomon
Takeda, Makoto
Bugge, Thomas H.
Kim, Semi
Park, Youngwoo
Marzi, Andrea
Poehlmann, Stefan
TI Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID A VIRUSES; PANDEMIC VIRUS; RECEPTOR-BINDING; SERINE-PROTEASE;
CATHEPSIN-L; DC-SIGNR; INFECTION; VIRULENCE; GENE; PATHOGENICITY
AB Proteolytic activation of the hemagglutinin (HA) protein is indispensable for influenza virus infectivity, and the tissue expression of the responsible cellular proteases impacts viral tropism and pathogenicity. The HA protein critically contributes to the exceptionally high pathogenicity of the 1918 influenza virus, but the mechanisms underlying cleavage activation of the 1918 HA have not been characterized. The neuraminidase (NA) protein of the 1918 influenza virus allows trypsin-independent growth in canine kidney cells (MDCK). However, it is at present unknown if the 1918 NA, like the NA of the closely related strain A/WSN/33, facilitates HA cleavage activation by recruiting the proprotease plasminogen. Moreover, it is not known which pulmonary proteases activate the 1918 HA. We provide evidence that NA-dependent, trypsin-independent cleavage activation of the 1918 HA is cell line dependent and most likely plasminogen independent since the 1918 NA failed to recruit plasminogen and neither exogenous plasminogen nor the presence of the A/WSN/33 NA promoted efficient cleavage of the 1918 HA. The transmembrane serine protease TMPRSS4 was found to be expressed in lung tissue and was shown to cleave the 1918 HA. Accordingly, coexpression of the 1918 HA with TMPRSS4 or the previously identified HA-processing protease TMPRSS2 allowed trypsin-independent infection by pseuodotypes bearing the 1918 HA, indicating that these proteases might support 1918 influenza virus spread in the lung. In summary, we show that the previously reported 1918 NA-dependent spread of the 1918 influenza virus is a cell line-dependent phenomenon and is not due to plasminogen recruitment by the 1918 NA. Moreover, we provide evidence that TMPRSS2 and TMPRSS4 activate the 1918 HA by cleavage and therefore may promote viral spread in lung tissue.
C1 [Chaipan, Chawaree; Marzi, Andrea; Poehlmann, Stefan] Univ Hosp Erlangen, Nikolaus Fiebiger Ctr Mol Med, D-91054 Erlangen, Germany.
[Chaipan, Chawaree; Marzi, Andrea; Poehlmann, Stefan] Univ Hosp Erlangen, Inst Clin & Mol Virol, D-91054 Erlangen, Germany.
[Kobasa, Darwyn] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada.
[Kobasa, Darwyn] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 3R2, Canada.
[Bertram, Stephanie; Glowacka, Ilona; Steffen, Imke; Tsegaye, Theodros Solomon; Poehlmann, Stefan] Hannover Med Sch, Inst Virol, D-30625 Hannover, Germany.
[Takeda, Makoto] Kyushu Univ, Fac Med, Dept Virol, Fukuoka 8128582, Japan.
[Bugge, Thomas H.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA.
[Kim, Semi; Park, Youngwoo] Korea Res Inst Biosci & Biotechnol, Therapeut Antibody Res Ctr, Taejon, South Korea.
[Marzi, Andrea] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada.
RP Marzi, A (reprint author), Virol Lab, Rocky Mt Labs, 903 S 4th St, Hamilton, MT 59840 USA.
EM marzia@niaid.nih.gov; Poehlmann.Stefan@MH-Hannover.DE
OI Tsegaye, Theodros Solomon/0000-0002-1573-4600; Pohlmann,
Stefan/0000-0001-6086-9136
FU NIH; Korean Ministry of Health and Welfare [BGC0800824]; Korea
Healthcare Technology RD Project; Ministry for Health, Welfare and
Family Affairs, Republic of Korea [A080264]; Deutsche
Forschungsgemeinschaft [SFB466/SFB587, GK1071]; Bundesministerium fur
Bildung und Forschung
FX This study was supported by the NIH Intramural Program (T. H. B.),
Korean Ministry of Health and Welfare grant BGC0800824 (to Y. P.), Korea
Healthcare Technology R&D Project, Ministry for Health, Welfare and
Family Affairs, Republic of Korea (grant A080264 to S. K.), grants
SFB466/SFB587 (A. M. and S. P.) and GK1071 (C. C.) from the Deutsche
Forschungsgemeinschaft, the M.D./Ph.D. program in Molecular Medicine and
Ph.D. program in Infection Biology at Hannover Medical School (T. S. T.
and I. S.), and the Bundesministerium fur Bildung und Forschung (I. G.,
S. B., and S. P.).
NR 47
TC 96
Z9 105
U1 1
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2009
VL 83
IS 7
BP 3200
EP 3211
DI 10.1128/JVI.02205-08
PG 12
WC Virology
SC Virology
GA 417AE
UT WOS:000264046000037
PM 19158246
ER
PT J
AU Peloponese, JM
Yasunaga, J
Kinjo, T
Watashi, K
Jeang, KT
AF Peloponese, Jean-Marie, Jr.
Yasunaga, Junichiro
Kinjo, Takao
Watashi, Koichi
Jeang, Kuan-Teh
TI Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell
Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-kappa B
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HTLV-I TAX; 1ST HUMAN RETROVIRUS; PROLYL ISOMERASE; CENTROSOME
AMPLIFICATION; TRANSCRIPTIONAL ACTIVITY; TRANSFORMING PROTEIN;
DNA-DAMAGE; C-FOS; ONCOPROTEIN; CANCER
AB Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL). The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation. ATL is a highly virulent cancer that is resistant to chemotherapeutic treatments. To understand this disease better, it is important to comprehend how HTLV-1 promotes cellular growth and survival. Tax activation of NF-kappa B is important for the proliferation and transformation of virus-infected cells. We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-kappa B activation.
C1 [Peloponese, Jean-Marie, Jr.] Univ Montpellier 1, F-34965 Montpellier, France.
[Peloponese, Jean-Marie, Jr.] Ctr Etud Agents Pathogens & Biotechnol Sante, CNRS, UM5236, F-34965 Montpellier, France.
[Peloponese, Jean-Marie, Jr.; Yasunaga, Junichiro; Kinjo, Takao; Watashi, Koichi; Jeang, Kuan-Teh] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA.
[Peloponese, Jean-Marie, Jr.] Univ Montpellier 2, Ctr Etud Agents Pathogenes & Biotechnol Sante, CNRS, UM5236, F-34095 Montpellier, France.
[Peloponese, Jean-Marie, Jr.] Univ Montpellier 2, Ctr Etud Agents Pathogenes & Biotechnol Sante, F-34095 Montpellier, France.
RP Peloponese, JM (reprint author), Univ Montpellier 1, F-34965 Montpellier, France.
EM jean-marie.peloponese@univ-montp1.fr
RI Jeang, Kuan-Teh/A-2424-2008
FU National Institute of Allergy and Infectious Diseases, the National
Institutes of Health
FX This work was supported by intramural funds from the National Institute
of Allergy and Infectious Diseases, the National Institutes of Health.
NR 74
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U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2009
VL 83
IS 7
BP 3238
EP 3248
DI 10.1128/JVI.01824-08
PG 11
WC Virology
SC Virology
GA 417AE
UT WOS:000264046000040
PM 19158244
ER
PT J
AU Ma, ZM
Stone, M
Piatak, M
Schweighardt, B
Haigwood, NL
Montefiori, D
Lifson, JD
Busch, MP
Miller, CJ
AF Ma, Zhong-Min
Stone, Mars
Piatak, Mike, Jr.
Schweighardt, Becky
Haigwood, Nancy L.
Montefiori, David
Lifson, Jeffrey D.
Busch, Michael P.
Miller, Christopher J.
TI High Specific Infectivity of Plasma Virus from the Pre-Ramp-Up and
Ramp-Up Stages of Acute Simian Immunodeficiency Virus Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HEPATITIS-C VIRUS; TRANSMITTED VIRAL-INFECTIONS; PRIMARY HIV-1
INFECTION; RHESUS MACAQUES; WINDOW-PERIOD; INTRAVAGINAL INOCULATION;
TRANSIENT VIREMIA; VAGINAL CHALLENGE; BLOOD COMPONENTS; B-VIRUS
AB To define the ratio of simian immunodeficiency virus (SIV) RNA molecules to infectious virions in plasma, a ramp-up-stage plasma pool was made from the earliest viral RNA (vRNA)-positive plasma samples (collected approximately 7 days after inoculation) from seven macaques, and a set-point-stage plasma pool was made from plasma samples collected 10 to 16 weeks after peak viremia from seven macaques; vRNA levels in these plasma pools were determined, and serial 10-fold dilutions containing 1 to 1,500 vRNA copies/ml were made. Intravenous (i.v.) inoculation of a 1-ml aliquot of diluted ramp-up-stage plasma containing 20 vRNA copies infected 2 of 2 rhesus macaques, while for the set-point-stage plasma, i.v. inoculation with 1,500 vRNA copies was needed to transmit infection. Further, when the heat-inactivated set-point-stage plasma pool was mixed with ramp-up-stage virions, infection of inoculated macaques was blocked. Notably, 2 of 2 animals inoculated with 85 ml of a pre-ramp-up plasma pool containing < 3 SIV RNA copies/ml developed SIV infections characterized by high levels of viral replication, demonstrating that "vRNA-negative" plasma collected from macaques in the pre-ramp-up stage is infectious. Furthermore, there is a high ratio of infectious virions to total virions in ramp-up-stage plasma (between 1: 1 and 1: 10) and a lower ratio in set-point-stage plasma (between 1: 75 and 1: 750). Heat-inactivated chronic-stage plasma can "neutralize" the highly infectious ramp-up-stage virions. These findings have implications for the understanding of the natural history of SIV and human immunodeficiency virus infection and transmission.
C1 [Ma, Zhong-Min; Stone, Mars; Miller, Christopher J.] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA.
[Ma, Zhong-Min; Stone, Mars; Miller, Christopher J.] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA.
[Miller, Christopher J.] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Sch Vet Med, Davis, CA 95616 USA.
[Piatak, Mike, Jr.] Sci Applicat Int Corp Frederick Inc, AIDS & Canc Virus Program, Natl Canc Inst, Frederick, MD USA.
[Schweighardt, Becky] Monogram Biosci Inc, San Francisco, CA USA.
[Haigwood, Nancy L.] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA.
[Montefiori, David] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Busch, Michael P.] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94118 USA.
[Busch, Michael P.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA.
RP Miller, CJ (reprint author), Univ Calif Davis, Calif Natl Primate Res Ctr, 1 Shields Ave, Davis, CA 95616 USA.
EM cjmiller@ucdavis.edu
FU National Center for Research Resources [U51R R00169]; National Institute
of Allergy and Infectious Diseases [P01 AI066314]; James B. Pendleton
Charitable Trust; National Cancer Institute, National Institutes of
Health [NO1-CO-124000, HHSN266200400088C]
FX This work was supported by Public Health Service grants U51R R00169,
from the National Center for Research Resources, and P01 AI066314, from
the National Institute of Allergy and Infectious Diseases, by a gift
from the James B. Pendleton Charitable Trust, and in part by federal
funds from the National Cancer Institute, National Institutes of Health,
under contracts NO1-CO-124000 and HHSN266200400088C.
NR 45
TC 57
Z9 61
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2009
VL 83
IS 7
BP 3288
EP 3297
DI 10.1128/JVI.02423-08
PG 10
WC Virology
SC Virology
GA 417AE
UT WOS:000264046000045
PM 19129448
ER
PT J
AU Camp, EA
Coker, AL
Robboy, SJ
Noller, KL
Goodman, KJ
Titus-Ernstoff, LT
Hatch, EE
Herbst, AL
Troisi, R
Kaufman, RH
Adam, E
AF Camp, Elizabeth A.
Coker, Ann L.
Robboy, Stanley J.
Noller, Kenneth L.
Goodman, Karen J.
Titus-Ernstoff, Linda T.
Hatch, Elizabeth E.
Herbst, Arthur L.
Troisi, Rebecca
Kaufman, Raymond H.
Adam, Ervin
TI Breast Cancer Screening in Women Exposed In Utero to Diethylstilbestrol
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID SELF-EXAMINATION; YOUNG-WOMEN; RISK; PREGNANCY; MOTHERS
AB Purpose: To determine if women exposed in utero to diethylstilbestrol (DES) are more likely than unexposed women to receive recommended or additional breast cancer screening examinations.
Methods: 1994 Diethylstilbestrol-Adenosis (DESAD) cohort data are used to assess the degree of recommended compliance of breast cancer screenings found in 3140 DES-exposed and 826 unexposed women. Participants were enrolled at four sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data that included reported frequency over the preceding 5 years (1990-1994) of breast-self examinations (BSEs), clinical breast examinations (CBEs), and mammograms.
Results: DES-exposed women exceeded annual recommendations for CBEs (aOR 2.20, 95% CI, 1.04-4.67) among women without a history of benign breast disease (BBD) compared with unexposed women. There were no other statistically significant differences between exposed and unexposed women who reported performing BSEs, CBEs(<40 years of age), and mammographies, regardless of BBD history.
Conclusions: The majority of DES-exposed women receive breast cancer screenings at least at recommended intervals, but over two thirds do not perform monthly BSEs. Future efforts should be focused on further educating this and other at-risk populations through mailed reminders and during patient consultations on the benefits of screening examinations.
C1 [Camp, Elizabeth A.; Coker, Ann L.; Goodman, Karen J.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
[Robboy, Stanley J.] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
[Robboy, Stanley J.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA.
[Noller, Kenneth L.] Univ Massachusetts, Med Ctr, Dept Obstet & Gynecol, Worcester, MA USA.
[Titus-Ernstoff, Linda T.] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03766 USA.
[Hatch, Elizabeth E.] Boston Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA USA.
[Herbst, Arthur L.] Univ Chicago, Dept Obstet & Gynecol, Chicago, IL 60637 USA.
[Troisi, Rebecca] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Kaufman, Raymond H.; Adam, Ervin] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA.
[Kaufman, Raymond H.] Methodist Hosp, Dept Obstet & Gynecol, Houston, TX 77030 USA.
[Adam, Ervin] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA.
RP Kaufman, RH (reprint author), 6550 Fannin,Suite 900, Houston, TX 77030 USA.
EM rkaufman@tmh.tmc.edu
RI Goodman, Karen/D-6823-2013;
OI Goodman, Karen/0000-0002-3790-3217; Hatch, Elizabeth/0000-0001-7901-3928
FU National Cancer Institute [1-CP-21166]
FX This study was supported by the National Cancer Institute under contact
1-CP-21166.
NR 29
TC 4
Z9 4
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD APR
PY 2009
VL 18
IS 4
BP 547
EP 552
DI 10.1089/jwh.2007.0580
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 431QL
UT WOS:000265077800018
PM 19361323
ER
PT J
AU Bhasin, S
Espeland, MA
Evans, WJ
Ferrucci, L
Fried, LP
Gill, TM
Pahor, M
Studenski, S
Guralnik, J
Nayfi, S
Romashkin, S
Perlstein, R
Burke, L
Parks, M
AF Bhasin, Shalender
Espeland, Mark A.
Evans, William J.
Ferrucci, Luigi
Fried, Linda P.
Gill, Thomas M.
Pahor, Marco
Studenski, Stephanie
Guralnik, Jack
Nayfi, Susan
Romashkin, Sergei
Perlstein, Robert
Burke, Laurie
Parks, Mary
TI Indications, Labeling, and Outcomes Assessment for Drugs Aimed at
Improving Functional Status in Older Persons: A Conversation Between
Aging Researchers and FDA Regulators
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
SCIENCES
LA English
DT Editorial Material
ID MUSCLE MASS SARCOPENIA; SKELETAL-MUSCLE; POSTMENOPAUSAL WOMEN;
BODY-COMPOSITION; FRAILTY; STRENGTH; MEN; DISABILITY; CARE; OSTEOPOROSIS
C1 [Bhasin, Shalender] Boston Univ, Sch Med, Boston, MA 02215 USA.
[Espeland, Mark A.] Wake Forest Univ Hlth Sci, Dept Biostat Sci, Winston Salem, NC USA.
[Evans, William J.] Univ Arkansas Med Sci, Donald W Reynolds Inst Aging, Little Rock, AR 72205 USA.
[Ferrucci, Luigi] NIA, Baltimore Longitudinal Study Aging, Bethesda, MD 20892 USA.
[Fried, Linda P.] Cornell Univ, Ithaca, NY 14853 USA.
[Gill, Thomas M.] Yale Univ, Sch Med, New Haven, CT 06520 USA.
[Pahor, Marco] Univ Florida, Sch Med, Gainesville, FL 32611 USA.
[Studenski, Stephanie] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA.
[Guralnik, Jack] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
[Nayfi, Susan; Romashkin, Sergei] NIA, Geriatr & Clin Gerontol Program, Bethesda, MD 20892 USA.
[Perlstein, Robert; Burke, Laurie; Parks, Mary] US FDA, Rockville, MD 20857 USA.
RP Evans, WJ (reprint author), Univ Arkansas Med Sci, Donald W Reynolds Inst Aging, Slot 806,4301 W Markham, Little Rock, AR 72205 USA.
EM evanswilliamj@uams.edu
NR 31
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U1 2
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD APR
PY 2009
VL 64
IS 4
BP 487
EP 491
DI 10.1093/gerona/gln042
PG 5
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 421XD
UT WOS:000264390700010
ER
PT J
AU Hanlon, JT
Boudreau, RM
Roumani, YF
Newman, AB
Ruby, CM
Wright, RM
Hilmer, SN
Shorr, RI
Bauer, DC
Simonsick, EM
Studenski, SA
AF Hanlon, Joseph T.
Boudreau, Robert M.
Roumani, Yazan F.
Newman, Anne B.
Ruby, Christine M.
Wright, Rollin M.
Hilmer, Sarah N.
Shorr, Ronald I.
Bauer, Douglas C.
Simonsick, Eleanor M.
Studenski, Stephanie A.
CA Health ABC Study
TI Number and Dosage of Central Nervous System Medications on Recurrent
Falls in Community Elders: The Health, Aging and Body Composition Study
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
SCIENCES
LA English
DT Article
DE Aged; Falls; Central nervous system medications
ID OLDER-ADULTS; PEOPLE; DRUGS; RISK; HOME; METAANALYSIS; ANALGESICS;
WITHDRAWAL; CONSENSUS; EUROPE
AB Few studies have examined the risk of multiple or high doses of combined central nervous system (CNS) medication use for recurrent falls in the elderly. The study objective was to evaluate whether multiple- or high-dose CNS medication use in older adults was associated with a higher risk of recurrent (>= 2) falls.
This longitudinal cohort study included 3,055 participants from the Health, Aging and Body Composition study who were well functioning at baseline. CNS medication use (benzodiazepine and opioid receptor agonists, antipsychotics, antidepressants) was determined annually (except Year 4) during in-person interviews. The number and summated standard daily doses (SDDs; low, medium, and high) of CNS medications were computed. Falls 1 year later were ascertained annually for 5 years.
For a period of 5 years, as many as 24.1% of CNS medication users took 2+ agents annually, whereas as no more than 18.9% of CNS medication users took high doses annually (3+ SDDs). Yearly, as many as 9.7% of participants reported recurrent falls. Multivariable Generalized Estimating Equation analyses showed that multiple CNS medication users compared with never users had an increased risk of sustaining 2+ falls (adjusted odds ratio [OR] 1.95; 95% confidence interval [CI] 1.35-2.81). Those taking high (3+) CNS SDDs also exhibited an increased risk of 2+ falls (adjusted OR 2.89; 95% CI 1.96-4.25).
Higher total daily doses of CNS medications were associated with recurrent falls. Further studies are needed to determine the impact of reducing the number of CNS medications and/or dosage on recurrent falls.
C1 [Hanlon, Joseph T.; Roumani, Yazan F.; Newman, Anne B.; Wright, Rollin M.; Studenski, Stephanie A.] Univ Pittsburgh, Sch Med, Dept Geriatr Med, Pittsburgh, PA 15213 USA.
[Hanlon, Joseph T.; Ruby, Christine M.] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15213 USA.
[Hanlon, Joseph T.; Studenski, Stephanie A.] Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Geriatr Res Educ, Pittsburgh, PA USA.
[Hanlon, Joseph T.; Studenski, Stephanie A.] Vet Affairs Pittsburgh Healthcare Syst, Ctr Clin, Pittsburgh, PA USA.
[Boudreau, Robert M.; Newman, Anne B.] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
[Hilmer, Sarah N.] Royal N Shore Hosp, St Leonards, NSW, Australia.
[Hilmer, Sarah N.] Univ Sydney, Sydney, NSW 2006, Australia.
[Shorr, Ronald I.] N Florida S Georgia Vet Hlth Syst Geriatr Res Edu, Gainesville, FL USA.
[Bauer, Douglas C.] Univ Calif San Francisco, Div Gen Internal Med, San Francisco, CA 94143 USA.
[Simonsick, Eleanor M.] NIA, Intramural Res Program, Baltimore, MD 21224 USA.
RP Hanlon, JT (reprint author), Univ Pittsburgh, Sch Med, Dept Geriatr Med, Kaufman Med Bldg,Suite 514,3471 5th Ave, Pittsburgh, PA 15213 USA.
EM hanlonj@dom.pitt.edu
RI Newman, Anne/C-6408-2013;
OI Newman, Anne/0000-0002-0106-1150; Hilmer, Sarah/0000-0002-5970-1501;
Boudreau, Robert/0000-0003-0162-5187
FU National Institute of Aging [R01AG027017, P30AG024827, N01-AG-6-2101,
N01-AG-6-2103, N01-AG-6-2106]; National Institutes of Health
FX This study was primarily supported by National Institute of Aging grants
(R01AG027017; P30AG024827, N01-AG-6-2101, N01-AG-6-2103, and
N01-AG-6-2106). This research was supported in part by the Intramural
Research program of the National Institutes of Health, National
Institute on Aging.
NR 39
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Z9 64
U1 2
U2 4
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD APR
PY 2009
VL 64
IS 4
BP 492
EP 498
DI 10.1093/gerona/gln043
PG 7
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 421XD
UT WOS:000264390700011
PM 19196642
ER
PT J
AU Freedman, BI
Hicks, PJ
Bostrom, MA
Cunningham, ME
Liu, Y
Divers, J
Kopp, JB
Winkler, CA
Nelson, GW
Langefeld, CD
Bowden, DW
AF Freedman, Barry I.
Hicks, Pamela J.
Bostrom, Meredith A.
Cunningham, Mary E.
Liu, Yongmei
Divers, Jasmin
Kopp, Jeffrey B.
Winkler, Cheryl A.
Nelson, George W.
Langefeld, Carl D.
Bowden, Donald W.
TI Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are
strongly associated with end-stage renal disease historically attributed
to hypertension in African Americans
SO KIDNEY INTERNATIONAL
LA English
DT Article
DE African American; end-stage renal disease; focal segmental
glomerulosclerosis; hypertension; hypertensive nephrosclerosis; MYH9
ID FOCAL SEGMENTAL GLOMERULOSCLEROSIS; CHRONIC KIDNEY-DISEASE;
BLOOD-PRESSURE; NEPHROSCLEROSIS; TRIAL; RISK; POPULATION; MUTATIONS;
ADMIXTURE; MEN
AB African Americans have high incidence rates of end-stage renal disease (ESRD) labeled as due to hypertension. As recent studies showed strong association with idiopathic and HIV-related focal segmental glomerulosclerosis and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in this ethnic group, we tested for MYH9 associations in a variety of kidney diseases. Fifteen MYH9 single-nucleotide polymorphisms were evaluated in 175 African Americans with chronic glomerulonephritis-associated ESRD, 696 African Americans reportedly with hypertension-associated ESRD, and 948 control subjects without kidney disease. Significant associations were detected with 14 of the 15 polymorphisms in all 871 non-diabetic patients with ESRD. In hypertension-associated ESRD cases alone, significant associations were found with 13 MYH9 polymorphisms and the previously reported E1 haplotype. Thus, hypertension-associated ESRD in African Americans is substantially related to MYH9 gene polymorphisms and this may explain the poor response to blood pressure control in those diagnosed with hypertensive nephrosclerosis. It is possible that many African Americans classified as having hypertension-associated ESRD have occult MYH9-associated segmental or global glomerulosclerosis. Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease.
C1 [Freedman, Barry I.] Wake Forest Univ, Sch Med, Nephrol Sect, Winston Salem, NC 27157 USA.
[Kopp, Jeffrey B.] NIDDKD, Kidney Dis Sect, Bethesda, MD 20892 USA.
[Winkler, Cheryl A.; Nelson, George W.] NCI, SAIC, Frederick, MD 21701 USA.
[Bowden, Donald W.] Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA.
RP Freedman, BI (reprint author), Wake Forest Univ, Sch Med, Nephrol Sect, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM bfreedma@wfubmc.edu
OI Kopp, Jeffrey/0000-0001-9052-186X
FU NIH [RO1 DK 070942, RO1 DK53591, N01-CO-12400, HHSN261200800001E];
NIDDK; NCI; Center for Cancer Research
FX This study was supported in part by NIH grants RO1 DK 070942 (BIF) and
RO1 DK53591 (DWB), and by the NIDDK and NCI Intramural Research
Programs. We are indebted to the local nephrology community, including
all physicians and their patients who participated, as well as to our
study coordinators Joyce Byers, Carrie Smith, Mitzie Spainhour,
Cassandra Bethea, and Sharon Warren. This project has been funded in
whole or in part with federal funds from the National Cancer Institute,
National Institutes of Health, under contract N01-CO-12400 and
HHSN261200800001E. The content of this publication does not necessarily
reflect the views or policies of the Department of Health and Human
Services, nor does mention of trade names, commercial products, or
organizations imply endorsement by the US Government. This research was
supported (in part) by the Intramural Research Program of the NIH,
National Cancer Institute, Center for Cancer Research.
NR 31
TC 126
Z9 137
U1 2
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0085-2538
J9 KIDNEY INT
JI Kidney Int.
PD APR
PY 2009
VL 75
IS 7
BP 736
EP 745
DI 10.1038/ki.2008.701
PG 10
WC Urology & Nephrology
SC Urology & Nephrology
GA 418VS
UT WOS:000264178100011
PM 19177153
ER
PT J
AU Brown, P
Gipson, C
AF Brown, Patricia
Gipson, Chester
TI A word from OLAW and USDA
SO LAB ANIMAL
LA English
DT Editorial Material
C1 [Brown, Patricia] NIH, OLAW, OER, OD,HHS, Bethesda, MD USA.
RP Brown, P (reprint author), NIH, OLAW, OER, OD,HHS, Bethesda, MD USA.
NR 4
TC 2
Z9 2
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0093-7355
J9 LAB ANIMAL
JI Lab Anim.
PD APR
PY 2009
VL 38
IS 4
BP 113
EP 113
DI 10.1038/laban0409-113b
PG 1
WC Veterinary Sciences
SC Veterinary Sciences
GA 424IK
UT WOS:000264560200006
PM 19308057
ER
PT J
AU Persad, G
Wertheimer, A
Emanuel, EJ
AF Persad, Govind
Wertheimer, Alan
Emanuel, Ezekiei J.
TI Ethical criteria for allocating health-care resources Reply
SO LANCET
LA English
DT Letter
C1 [Persad, Govind; Wertheimer, Alan; Emanuel, Ezekiei J.] NIH, Dept Bioeth, Ctr Clin, Bethesda, MD 20892 USA.
RP Emanuel, EJ (reprint author), NIH, Dept Bioeth, Ctr Clin, Bethesda, MD 20892 USA.
EM eemanuel@nih.gov
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD APR-MAY
PY 2009
VL 373
IS 9673
BP 1425
EP 1426
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 437QL
UT WOS:000265501900024
ER
PT J
AU Brandwein, JM
Leber, BF
Howson-Jan, K
Schimmer, AD
Schuh, AC
Gupta, V
Yee, KWL
Wright, J
Moore, M
MacAlpine, K
Minden, MD
AF Brandwein, J. M.
Leber, B. F.
Howson-Jan, K.
Schimmer, A. D.
Schuh, A. C.
Gupta, V.
Yee, K. W. L.
Wright, J.
Moore, M.
MacAlpine, K.
Minden, M. D.
CA NCI CTEP Protocol 6070
TI A phase I study of tipifarnib combined with conventional induction and
consolidation therapy for previously untreated patients with acute
myeloid leukemia aged 60 years and over
SO LEUKEMIA
LA English
DT Article
DE acute myeloid leukemia; chemotherapy; farnesyltransferase inhibitors
ID ACUTE MYELOGENOUS LEUKEMIA; COLONY-STIMULATING FACTOR;
FARNESYLTRANSFERASE INHIBITOR TIPIFARNIB; COUNCIL AML11 TRIAL;
ELDERLY-PATIENTS; ONCOLOGY-GROUP; OLDER-ADULTS; CLASSIFICATION;
ORGANIZATION; RISK
AB Patients aged 60 years and over with previously untreated acute myeloid leukemia were enrolled in a Phase I study combining tipifarnib with standard induction therapy. The regimen consisted of cytarabine 100 mg/m(2)/day continuous intravenous (i.v.) infusion on days 1-7, daunorubicin 60 mg/m(2)/day i.v. push x 3 on days 6-8 and tipifarnib twice daily on days 6-15. Tipifarnib was escalated over four dose levels (200, 300, 400 and 600 mg). Patients achieving complete response (CR) were eligible to receive one consolidation using the same regimen. The following dose-limiting toxicities (DLTs) were identified during induction: dose level I: 2/6 (hyperbilirubinemia, respiratory arrest), level II: 0/3, level III: 0/3 and level IV: 4/10 (one each of diarrhea, neutropenic enterocolitis, arrhythmia and delayed hematologic recovery post-consolidation). There were no DLTs due to delayed hematologic recovery post-induction. Of 22 evaluable patients, there were 10 CR, 2 morphologic leukemia-free state (MLFS), 2 partial remission (PR) and 8 non-responders. Of seven patients with adverse risk cytogenetics, there were four CR/MLFS and one PR. In summary, this regimen was well tolerated and the maximum tolerated dose was not reached, although somewhat more severe gastrointestinal toxicity was seen at dose level IV. Tipifarnib 600 mg b.i.d. is considered the recommended dose for further study using this regimen.
C1 [Brandwein, J. M.; Schimmer, A. D.; Schuh, A. C.; Gupta, V.; Yee, K. W. L.; Moore, M.; MacAlpine, K.; Minden, M. D.] Univ Toronto, Dept Med Oncol & Hematol, Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada.
[Leber, B. F.] Hamilton Hlth Sci, Dept Med, Hamilton, ON, Canada.
[Howson-Jan, K.] London Hlth Sci Ctr, Dept Med, London, ON, Canada.
[Wright, J.] NCI, NIH, Bethesda, MD 20892 USA.
RP Brandwein, JM (reprint author), Univ Toronto, Dept Med Oncol & Hematol, Princess Margaret Hosp, 610 Univ Ave,Room 5-109, Toronto, ON M5G 2M9, Canada.
EM joseph.brandwein@uhn.on.ca
NR 16
TC 10
Z9 10
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0887-6924
J9 LEUKEMIA
JI Leukemia
PD APR
PY 2009
VL 23
IS 4
BP 631
EP 634
DI 10.1038/leu.2008.341
PG 4
WC Oncology; Hematology
SC Oncology; Hematology
GA 433QL
UT WOS:000265220800001
PM 19092853
ER
PT J
AU Liu, W
Dahnke, H
Rahmer, J
Jordan, EK
Frank, JA
AF Liu, Wei
Dahnke, Hannes
Rahmer, Juergen
Jordan, E. Kay
Frank, Joseph A.
TI Ultrashort T-2* Relaxometry for Quantitation of Highly Concentrated
Superparamagnetic Iron Oxide (SPIO) Nanoparticle Labeled Cells
SO MAGNETIC RESONANCE IN MEDICINE
LA English
DT Article
DE superparamagnetic iron oxide nanoparticles; cell labeling; T-2*
relaxometry
ID MAGNETIC-RESONANCE TRACKING; STATIC DEPHASING REGIME; STEM-CELLS;
IN-VIVO; CELLULAR THERAPY; MIGRATION; TISSUE; MODEL; RAT
AB A new method was developed to measure ultrashort T-2* relaxation in tissues containing a focal area of superparamagnetic iron oxide (SPIO) nanoparticle-labeled cells in which the T-2* decay is too short to be accurately measured using regular gradient echo T-2* mapping. The proposed method utilizes the relatively long T-2 relaxation of SPIO-labeled cells and acquires a series of spin echo images with the readout echo shifted to sample the T-2* decay curve. MRI experiments in phantoms and rats with SPIO-labeled tumors demonstrated that it can detect ultrashort T-2* down to 1 ms or less. The measured T-2* values were about 10% higher than those from the ultrashort TE (LITE) technique. The shorter the TE, the less the measurements deviated from the UTE T-2* mapping. Combined with the regular T-2* mapping, this technique is expected to provide quantitation of highly concentrated iron-labeled cells from direct cell transplantation. Magn Reson Med 61:761-766, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Liu, Wei] Philips Res N Amer, Briarcliff Manor, NY 10510 USA.
[Liu, Wei; Jordan, E. Kay; Frank, Joseph A.] NIH, Lab Diagnost Radiol Res, Expt Neuroimaging Sect, Ctr Clin, Bethesda, MD 20892 USA.
[Dahnke, Hannes; Rahmer, Juergen] Philips Res, Hamburg, Germany.
RP Liu, W (reprint author), Philips Res N Amer, 345 Scarborough Rd, Briarcliff Manor, NY 10510 USA.
EM jafrank@helix.nih.gov; jafrank@helix.nih.gov
OI Rahmer, Jurgen/0000-0001-8514-4801
FU Intramural NIH HHS [ZIA CL090007-03]
NR 19
TC 36
Z9 38
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0740-3194
J9 MAGN RESON MED
JI Magn. Reson. Med.
PD APR
PY 2009
VL 61
IS 4
BP 761
EP 766
DI 10.1002/mrm.21923
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 423LY
UT WOS:000264499000002
PM 19191285
ER
PT J
AU Reiter, DA
Lin, PC
Fishbein, KW
Spencer, RG
AF Reiter, David A.
Lin, Ping-Chang
Fishbein, Kenneth W.
Spencer, Richard G.
TI Multicomponent T-2 Relaxation Analysis in Cartilage
SO MAGNETIC RESONANCE IN MEDICINE
LA English
DT Article
DE spin-spin relaxation; macromolecular compartments; cartilage; magnetic
resonance
ID ARTICULAR-CARTILAGE; MAGNETIC-RESONANCE; COLLAGEN DYNAMICS; NMR
RELAXATION; BREAST-TISSUE; WATER; DIFFUSION; MUSCLE; MRI; SPECTROSCOPY
AB MR techniques are sensitive to the early stages of osteoarthritis, characterized by disruption of collagen and loss of proteoglycan (PG), but are of limited specificity. Here, water compartments in normal and trypsin-degraded bovine nasal cartilage were identified using a nonnegative least squares multiexponential analysis of T-2 relaxation. Three components were detected: T-2,T-1 = 2.3 ms, T-2,T-2 = 25.2 ms, and T-2,T-3 = 96.3 ms, with fractions w(1) = 6.2%, w(2) = 14.5%, and w(3) = 79.3%, respectively. Trypsinization resulted in increased (P < 0.01) values of T-2,T-2 = 64.2 ms and T-2,T-3 = 149.4 ms, supporting their assignment to water compartments that are bound and loosely associated with PG, respectively. The T-2 of the rapidly relaxing component was not altered by digestion, supporting assignment to relatively immobile collagen-bound water. Relaxation data were simulated for a range of TE, number of echoes, and SNR to guide selection of acquisition parameters and assess the accuracy and precision of experimental results. Based on this, the expected experimental accuracy of measured T(2)s and associated weights was within 2% and 4% respectively, with precision within 1% and 3%. These results demonstrate the potential of multiexponential T-2 analysis to increase the specificity of MR characterization of cartilage. Magn Reson Med 61:803-809, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Reiter, David A.; Lin, Ping-Chang; Fishbein, Kenneth W.; Spencer, Richard G.] NIA, NIH, Magnet Resonance Imaging & Spect Sect, Baltimore, MD 21224 USA.
RP Spencer, RG (reprint author), NIA, NIH, Magnet Resonance Imaging & Spect Sect, GRC 4D-06, Baltimore, MD 21224 USA.
EM spencer@helix.nih.gov
RI Lin, Ping-Chang/C-9811-2009;
OI Lin, Ping-Chang/0000-0003-0918-4072; Fishbein,
Kenneth/0000-0002-6353-4603
FU NIH; National Institute on Aging
FX This work was supported by the Intramural Research Program of the NIH,
National Institute on Aging.
NR 30
TC 73
Z9 74
U1 0
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0740-3194
J9 MAGN RESON MED
JI Magn. Reson. Med.
PD APR
PY 2009
VL 61
IS 4
BP 803
EP 809
DI 10.1002/mrm.21926
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 423LY
UT WOS:000264499000007
PM 19189393
ER
PT J
AU Shin, WY
Gu, H
Yang, YH
AF Shin, Wanyong
Gu, Hong
Yang, Yihong
TI Fast High-Resolution T-1 Mapping Using Inversion-Recovery Look-Locker
Echo-Planar Imaging at Steady State: Optimization for Accuracy and
Reliability
SO MAGNETIC RESONANCE IN MEDICINE
LA English
DT Article
DE magnetic resonance imaging; Fast T-1 measurement; Look-Locker
echo-planar imaging; steady state; parameter optimization
ID RELAXATION-TIMES; IN-VIVO; MAGNETIZATION-TRANSFER; WATER EXCHANGE; HUMAN
BRAIN; ONE-SHOT; FIELD; INHOMOGENEITIES; QUANTIFICATION; PULSES
AB A fast T-1 measurement sequence using inversion recovery Look-Locker echo-planar imaging at steady state (IR LL-EPI SS) is presented. Delay time for a full magnetization recovery is not required in the sequence, saving acquisition time significantly for high-resolution T-1 mapping. Imaging parameters of the IR LL-EPI SS sequence were optimized to minimize the bias from the excitation pulses imperfection and to maximize the accuracy and reliability of T-1 measurements, which are critical for its applications. Compared with the conventional inversion recovery Look-Locker echo-planar imaging (IR LL-EPI) sequence, IR LL-EPI SS method preserves similar accuracy and reliability, while saving 20% in acquisition time. Optimized IR LL-EPI SS provided quantitative T-1 mapping with 1 x 1 x 4 mm(3) resolution and whole-brain coverage (28 slices) in approximately 4 min. Magn Reson Med 61:899-906, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Shin, Wanyong; Gu, Hong; Yang, Yihong] NIDA, Neuroimaging Res Branch, NIH, Baltimore, MD 21224 USA.
RP Shin, WY (reprint author), NIDA, Neuroimaging Res Branch, NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA.
EM shinwa@mail.nih.gov
FU Intramural Research Program of the National Institute on Drug Abuse
(NIDA); National Institutes of Health (NTH)
FX This work was supported by the Intramural Research Program of the
National Institute on Drug Abuse (NIDA), National Institutes of Health
(NTH). The authors would like, to thank Dr. Thomas Ross and Dr. Betty Jo
Salmeron for helpful discussion, Kimberly Modo and Loretta Spurgeon for
recruiting participants, and Eliscia Smith for technical support.
NR 23
TC 24
Z9 24
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0740-3194
J9 MAGN RESON MED
JI Magn. Reson. Med.
PD APR
PY 2009
VL 61
IS 4
BP 899
EP 906
DI 10.1002/mrm.21836
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 423LY
UT WOS:000264499000019
PM 19195021
ER
PT J
AU Walrath, JC
Fox, K
Truffer, E
Alvord, WG
Quinones, OA
Reilly, KM
AF Walrath, Jessica C.
Fox, Kristi
Truffer, Erika
Alvord, W. Gregory
Quinones, Octavio A.
Reilly, Karlyne M.
TI Chr 19(A/J) modifies tumor resistance in a sex- and
parent-of-origin-specific manner
SO MAMMALIAN GENOME
LA English
DT Article
ID NERVE SHEATH TUMORS; NEUROFIBROMATOSIS TYPE-1; SUSCEPTIBILITY; MUTANT;
MODEL; NF1
AB Neurofibromatosis type 1 (NF1) is one of the most common human genetic diseases affecting the nervous system and predisposes individuals to cancer, including peripheral nerve sheath tumors (PNSTs) and astrocytomas. Modifiers in the genetic background affect the severity of the disease and we have previously mapped two modifier loci, Nstr1 and Nstr2, that influence resistance to PNSTs in the Nf1-/+;Trp53-/+cis mouse model of NF1. We report here the analysis of Nstr1 in isolation from other epistatic loci using a chromosome substitution strain, and further show that a modifier locus (or loci) on chromosome 19 influences resistance to both PNSTs and astrocytomas. This modifier locus interacts with sex, resulting in sex-specific modification of tumors. Allele variability on chromosome 19 affects both the timing and the penetrance of the growth of different tumor types associated with NF1, specifically PNSTs and astrocytoma. These results indicate that modifiers of cancer susceptibility interact and affect tumorigenesis under different genetic conditions and demonstrate the power of chromosome substitution strains to study genetic modifiers.
C1 [Walrath, Jessica C.; Reilly, Karlyne M.] NCI, Mouse Canc Genet Program, Frederick, MD 21702 USA.
[Fox, Kristi; Truffer, Erika] Sci Applicat Int Corp, Frederick, MD 21702 USA.
[Alvord, W. Gregory; Quinones, Octavio A.] NCI, Data Management Serv Inc, Frederick, MD 21702 USA.
RP Reilly, KM (reprint author), NCI, Mouse Canc Genet Program, W 7th St,Bldg 560,Room 32-31B,POB B, Frederick, MD 21702 USA.
EM kreilly@ncifcrf.gov
FU Intramural Research Program of the NIH, National Cancer Institute;
National Cancer Institute [NO1-CO-12400]
FX We thank R. Tuskan, K. Rogers, and staff for technical assistance, and
S. Sharan, L. Tessarollo, B. Mock, N. Jenkins, and K. Hunter for helpful
discussions on the manuscript. We particularly appreciate the
constructive comments from anonymous scientific reviewers that improved
the analysis of the presented data. This project has been funded by the
Intramural Research Program of the NIH, National Cancer Institute, and
with federal funds from the National Cancer Institute under contract
NO1-CO-12400 to SAIC Frederick. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of tradenames, commercial products,
or organizations imply endorsements by the U. S. Government.
NR 14
TC 22
Z9 22
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0938-8990
J9 MAMM GENOME
JI Mamm. Genome
PD APR
PY 2009
VL 20
IS 4
BP 214
EP 223
DI 10.1007/s00335-009-9179-4
PG 10
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
GA 432RS
UT WOS:000265152400003
PM 19347398
ER
PT J
AU Cupul-Uicab, LA
Gladen, BC
Hernandez-Avila, M
Longnecker, MP
AF Cupul-Uicab, Lea A.
Gladen, Beth C.
Hernandez-Avila, Mauricio
Longnecker, Matthew P.
TI Reliability of reported breastfeeding duration among reproductive-aged
women from Mexico
SO MATERNAL AND CHILD NUTRITION
LA English
DT Article
DE breastfeeding; exclusive breastfeeding; intraclass correlation
coefficient; lactation; recall; reliability
ID NATIONAL NUTRITION SURVEY; MATERNAL RECALL; GENETIC PREDISPOSITION;
ANOGENITAL DISTANCE; PUBLISHED EVIDENCE; DIABETES-MELLITUS; CHILDHOOD
OBESITY; ELDERLY-WOMEN; MALE NEWBORNS; COWS MILK
AB Breastfed children have lower risk of infectious diseases, post-neonatal mortality and chronic diseases later in life. Because epidemiologic studies usually rely on reported history of previous breastfeeding, data on the accuracy and precision of recalled histories allow improved interpretation of the epidemiologic findings.
We evaluated the reliability of two reported breastfeeding durations in 567 reproductive-aged women from Mexico using information obtained from nearly identical sets of questions applied at different times after weaning. We compared differences between reports, and examined the intraclass correlation coefficient (ICC) for any and for exclusive breastfeeding (EBF). Logistic regression was used to evaluate the determinants of poor recall (difference between reports of > 20%).
The reliability of duration of any breastfeeding was high (ICC 0.94). Overall, differences between reports of duration were usually < 1 month, and for 385/567, the difference was <= 0.5 months. Predictors of poorer recall were having >= 4 children, and time between reports of > 2 months. The only predictor of better recall was greater age of the baby at weaning. The reliability of EBF duration was lower (ICC 0.49).
In this population with a relatively long duration of breastfeeding, reliability of any breastfeeding duration was high. Age, education and previous breastfeeding were not important predictors of recall, in contrast to findings in earlier studies. Consistent with previous reports, however, parity and length of recall were associated with poorer recall of duration of any breastfeeding. Future studies that use reported breastfeeding duration may want to consider the effect of these variables on recall.
C1 [Cupul-Uicab, Lea A.; Longnecker, Matthew P.] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Cupul-Uicab, Lea A.; Hernandez-Avila, Mauricio] Inst Nacl Salud Publ, Ctr Populat Hlth Res, Cuernavaca 62508, Morelos, Mexico.
[Gladen, Beth C.] NIEHS, Biostat Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Hernandez-Avila, Mauricio] Minist Hlth, Subsecretana Promoc & Prevenc Salud, Mexico City 06696, DF, Mexico.
RP Cupul-Uicab, LA (reprint author), NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, MD A3-05,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM cupuluicabl@niehs.nih.gov
RI CUPUL UICAB, LEA/C-8699-2014;
OI CUPUL UICAB, LEA/0000-0001-6190-4474; Longnecker,
Matthew/0000-0001-6073-5322
FU Intramural NIH HHS [Z99 ES999999, Z01 ES044009-07]; NIEHS NIH HHS
[N01-ES-15467]
NR 42
TC 13
Z9 16
U1 0
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1740-8695
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD APR
PY 2009
VL 5
IS 2
BP 125
EP 137
DI 10.1111/j.1740-8709.2008.00159.x
PG 13
WC Nutrition & Dietetics; Pediatrics
SC Nutrition & Dietetics; Pediatrics
GA 417MY
UT WOS:000264081400004
PM 19292747
ER
PT J
AU Burr, T
Chowell, G
AF Burr, Tom
Chowell, Gerardo
TI THE REPRODUCTION NUMBER R-t IN STRUCTURED AND NONSTRUCTURED POPULATIONS
SO MATHEMATICAL BIOSCIENCES AND ENGINEERING
LA English
DT Article
DE reproduction number; generation interval; structured population
ID ACUTE RESPIRATORY SYNDROME; EPIDEMIC MODELS; INFECTIOUS-DISEASE;
REAL-TIME; TRANSMISSION; NETWORKS; DYNAMICS; HETEROGENEITY; INTERVAL;
SIZE
AB Using daily counts of newly infected individuals, Wallinga and Teunis (WT) introduced a conceptually simple method to estimate the number of secondary cases per primary case (R-t) for a given day. The method requires an estimate of the generation interval probabilities density function (pdf),which specifies the probabilities for the times between symptom onset in a primary case and symptom onset in a corresponding secondary case. Other methods to estimate R-t are based on explicit models such as the SIR model; therefore, one might expect the WT method to be more robust to departures from SIR type behavior. This paper uses simulated data to compare the quality of daily R-t estimates based on a SIR model to those using the WT method for both structured (classical SIR assumptions are violated) and nonstructured (classical SIR assumptions hold) populations. By using detailed simulations that record the infection day of each new infection and the donor-recipienti dentities, the true R-t and the generation interval pdf is known with negligible error. We find that the generation interval pdf is time dependent in all cases, which agrees with recent results reported else where. We also find that the WT method performs essentially the same in the structured populations (except for a spatial network) as it does in the nonstructured population. And, the WT method does as well or better than a SIR-model based method in three of the four structured populations. Therefore, even if the contact patterns are heterogenous as in the structured populations evaluated here, the WT method provides reasonable estimates of R-t, as does the SIR method.
C1 [Burr, Tom] Los Alamos Natl Lab, Stat Sci Grp, Los Alamos, NM 87545 USA.
[Chowell, Gerardo] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA.
[Chowell, Gerardo] NIH, Div Epidemiol & Populat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Burr, T (reprint author), Los Alamos Natl Lab, Stat Sci Grp, POB 1663, Los Alamos, NM 87545 USA.
EM tburr@lanl.gov; gchowell@asu.edu
RI Chowell, Gerardo/A-4397-2008; Chowell, Gerardo/F-5038-2012
OI Chowell, Gerardo/0000-0003-2194-2251
NR 44
TC 1
Z9 1
U1 1
U2 5
PU AMER INST MATHEMATICAL SCIENCES
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA
SN 1547-1063
J9 MATH BIOSCI ENG
JI Math. Biosci. Eng.
PD APR
PY 2009
VL 6
IS 2
SI SI
BP 239
EP 259
DI 10.3934/mbe.2009.6.239
PG 21
WC Mathematical & Computational Biology
SC Mathematical & Computational Biology
GA 433FZ
UT WOS:000265191000003
PM 19364151
ER
PT J
AU Haruyama, N
Sreenath, TL
Suzuki, S
Yao, XM
Wang, ZG
Wang, Y
Honeycutt, C
Iozzo, RV
Young, MF
Kulkarni, AB
AF Haruyama, Naoto
Sreenath, Taduru L.
Suzuki, Shigeki
Yao, Xiaomei
Wang, Zhigang
Wang, Yong
Honeycutt, Cherlita
Iozzo, Renato V.
Young, Marian F.
Kulkarni, Ashok B.
TI Genetic evidence for key roles of decorin and biglycan in dentin
mineralization
SO MATRIX BIOLOGY
LA English
DT Article
DE Dentin sialophosphoprotein (DSPP); Biglycan; Decorin; Knockout mouse;
Dentin mineralization; Dentinogenesis imperfecta (DGI)
ID LEUCINE-RICH PROTEOGLYCANS; EXTRACELLULAR-MATRIX; TARGETED DISRUPTION;
DENTINOGENESIS IMPERFECTA; COLLAGEN FIBRILLOGENESIS; SIBLING PROTEINS;
DSPP GENE; GROWTH; SIALOPROTEIN; BONES
AB Targeted disruption of the dentin sialophosphoprotein (DSPP) gene in the mice (Dspp(-/-)) results in dentin mineralization defects with enlarged predentin phenotype similar to human dentinogenesis imperfecta type Ill. Using DSPP/biglycan (Dspp(-/-)Bgn(-/0)) and DSPP/decorin (Dspp(-/-)Dcn(-/-)) double knockout mice, here we determined that the enlarged predentin layer in Dspp(-/-) teeth is rescued in the absence of decorin, but not in the absence of biglycan. However, Fourier transform infrared (FTIR) spectroscopy analysis reveals similar hypomineralization of dentin in both Dspp(-/-)Bgn(-/0) and Dspp(-/-)Dcn(-/-) teeth. Atomic force microscopy (AFM) analysis of collagen fibrils in dentin shows subtle differences in the collagen fibril morphology in these genotypes. The reduction of enlarged predentin in Dspp(-/-)Dcn(-/-) mice suggests that the elevated level of decorin in Dspp(-/-) predentin interferes with the mineralization process at the dentin mineralization front. On the other hand, the lack of DSPP and biglycan leads to the increased number of calcospherites in Dspp(-/-)Bgn(-/0) predentin, suggesting that a failure in coalescence of calcospherites was augmented in Dspp(-/-)Bgn(-/0) teeth as compared to Dspp(-/-) teeth. These findings indicate that normal expression of small leucine rich proteoglycans, such as biglycan and decorin, plays an important role in the highly orchestrated process of dentin mineralization. Published by Elsevier B.V.
C1 [Kulkarni, Ashok B.] NIDCR, Funct Genom Sect, LCDB, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Young, Marian F.] Natl Inst Dent & Craniofacial Res, Mol Biol Bones & Teeth Sect, Craniofacial & Skeletal Dis Branch, NIH,Dept Hlth & Human Serv, Bethesda, MD USA.
[Yao, Xiaomei; Wang, Zhigang; Wang, Yong] Univ Missouri, Sch Dent, Dept Oral Biol, Kansas City, MO USA.
[Iozzo, Renato V.] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA.
[Iozzo, Renato V.] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
RP Kulkarni, AB (reprint author), NIDCR, Funct Genom Sect, LCDB, NIH,Dept Hlth & Human Serv, 30 Convent Dr,MSC 4395, Bethesda, MD 20892 USA.
EM ak40m@nih.gov
RI Haruyama, Naoto/D-1993-2011;
OI Haruyama, Naoto/0000-0001-6225-5816; Iozzo, Renato/0000-0002-5908-5112
FU Division of National Institute of Dental and Craniofacial Research
FX We would like to acknowledge Dr. Changqi Xu for the AFM data analysis.
We would like to thank Harry Grant for the editorial assistance. These
studies were supported by the intramural Division of National Institute
of Dental and Craniofacial Research.
NR 36
TC 21
Z9 25
U1 3
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0945-053X
J9 MATRIX BIOL
JI Matrix Biol.
PD APR
PY 2009
VL 28
IS 3
BP 129
EP 136
DI 10.1016/j.matbio.2009.01.005
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 455KJ
UT WOS:000266757900002
PM 19379665
ER
PT J
AU Borraccino, A
Lemma, P
Iannotti, RJ
Zambon, A
Dalmasso, P
Lazzeri, G
Giacchi, M
Cavallo, F
AF Borraccino, Alberto
Lemma, Patrizia
Iannotti, Ronald J.
Zambon, Alessio
Dalmasso, Paola
Lazzeri, Giacomo
Giacchi, Mariano
Cavallo, Franco
TI Socioeconomic Effects on Meeting Physical Activity Guidelines:
Comparisons among 32 Countries
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE HEALTH BEHAVIOUR IN SCHOOL-AGED CHILDREN (HBSC); ADOLESCENCE;
INTERNATIONAL SURVEY; PHYSICAL ACTIVITY GUIDELINE DETERMINANTS;
CHILDREN'S HABITS
ID SEDENTARY BEHAVIORS; HEALTH BEHAVIOR; ADOLESCENTS; CHILDREN; YOUTH;
OBESITY; DETERMINANTS; INTERVENTIONS; RELIABILITY; TELEVISION
AB BORRACCINO, A., P. LEMMA, R. J. IANNOTTI, A. ZAMBON, P. DALMASSO, G. LAZZERI, M. GIACCHI, and F. CAVALLO. Socioeconomic Effects on Meeting Physical Activity Guidelines: Comparisons among 32 Countries. Med. Sci. Sports Exerc., Vol. 41, No. 4, pp. 749-756, 2009. Purpose: This study examined the relationship between age and gender with physical activity (PA) and how meeting of PA guidelines (PAGL) is related to socioeconomic status (SES) and sedentary behaviors (SB). Methods: Data were collected from 11-, 13-, and 15-yr-old students in 32 countries participating in the Health Behaviour in School-aged Children (HBSC) survey 2001/2002. A self-completed questionnaire assessed weekly moderate-to-vigorous physical activity (MVPA) and SB for the past 7 d and MVPA for a typical week. SES was assessed using the Family Affluence Scale (FAS). Results: None of the countries averaged enough M7VPA to meet PAGL. The pattern of MVPA across age and gender was consistent among all countries. In all countries, older children were less active when compared with the youngest children; girls were significantly less active than boys were (mean hours per week of MVPA 3.52 +/- 1.88 vs 4.13 +/- 1.95) and were more likely to not meet the PAGL. SES was significantly associated with the amount of reported MVPA. SES and PAGL were not significantly related in seven countries, and a significant decrease in the influence of age was observed in these countries compared with other countries. Conclusions: Levels of MVPA during adolescence showed consistent patterns across countries in relation to age, gender, and social class. The limited effect of age on PA in countries where the influence of social class was less strong suggests the possibility of a moderating effect of context in the development of habits acquired during childhood.
C1 [Borraccino, Alberto; Lemma, Patrizia; Zambon, Alessio; Dalmasso, Paola; Cavallo, Franco] Univ Turin, Dept Publ Hlth & Microbiol, IT, I-10126 Turin, Italy.
[Iannotti, Ronald J.] NICHHD, NICHD, Bethesda, MD 20892 USA.
[Lazzeri, Giacomo; Giacchi, Mariano] Univ Siena, Dept Publ Hlth, I-53100 Siena, Italy.
RP Borraccino, A (reprint author), Univ Turin, Dept Publ Hlth & Microbiol, IT, Via Santena 5bis, I-10126 Turin, Italy.
EM alberto.borraccino@unito.it
RI Lazzeri, Giacomo/B-5723-2012; Borraccino, Alberto/C-9013-2012; Dalmasso,
Paola/F-8555-2013;
OI Lazzeri, Giacomo/0000-0002-9095-7652; Borraccino,
Alberto/0000-0001-8235-8775; Dalmasso, Paola/0000-0001-6081-6966; LEMMA,
Patrizia/0000-0002-1250-4316
FU Piedmont Region; University of Turin; Eunice Kennedy Shriver National
Institute of Child Health and Human Development
FX The results of the presented study do no constitute endorsement by ACSM.
NR 38
TC 63
Z9 65
U1 3
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD APR
PY 2009
VL 41
IS 4
BP 749
EP 756
DI 10.1249/MSS.0b013e3181917722
PG 8
WC Sport Sciences
SC Sport Sciences
GA 427ZJ
UT WOS:000264817300003
PM 19276860
ER
PT J
AU Amar, MJA
Shamburek, RD
Vaisman, B
Knapper, CL
Foger, B
Hoyt, RF
Santamarina-Fojo, S
Brewer, HB
Remaley, AT
AF Amar, Marcelo J. A.
Shamburek, Robert D.
Vaisman, Boris
Knapper, Cathenine L.
Foger, Bernhard
Hoyt, Robert F., Jr.
Santamarina-Fojo, Silvia
Brewer, Hollis B., Jr.
Remaley, Alan T.
TI Adenoviral expression of human lecithin-cholesterol acyltransferase in
nonhuman primates leads to an antiatherogenic lipoprotein phenotype by
increasing high-density lipoprotein and lowering low-density lipoprotein
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CORONARY-HEART-DISEASE; DOSE-DEPENDENT MANNER; E KNOCKOUT MICE;
TRANSGENIC RABBITS; HDL METABOLISM; A-I; LECITHINCHOLESTEROL
ACYLTRANSFERASE; ENHANCED ATHEROSCLEROSIS; PLASMA LECITHIN; LDL RECEPTOR
AB Lecithin-cholesterol acyltransferase (LCAT), it key enzyme in high-density lipoprotein (HDL) metabolism, has been proposed to have atheroprotective properties by promoting reverse cholesterol transport. Overexpression of LCAT in various animal models, however, has led to conflicting results Oil its, overall effect on lipoproteins and atherosclerosis. In this study, the effect of overexpression of LCAT in nonhuman primates on lipoprotein metabolism is examined. Human LCAT was expressed with adenovirus in squirrel monkeys (n = 8), resulting on day 4 in a 22-fold increase of LCAT activity (257 +/- 23 vs 5618 +/- 799 nmol mL(-1) h(-1), P <.0001). At its peak, LCAT was found to nearly double the level of HDL cholesterol from baseline (113 +/- 7 vs 260 +/- 24 mg/dL, P <.01). High-density lipoprotein formed after treatment with the adenovirus wits larger in size, as assessed by fast protein liquid chromatography (FPLC) analysis. By kinetic studies, it was determined that there was a decrease in apolipoprotein (Apo) A-I resident time (0.373 +/- 0.027 vs 0.685 +/- 0.045 d(-1), P <.0001) and almost a doubling in the ApoA-I synthetic rate (22 +/- 2 vs 41 +/- 3 mg kg(-1) d(-1), P <.0001), but no overall change in ApoA-I levels. In addition, increased expression of LCAT was associated with a 37% reduction of ApoB levels (12 +/- 1 vs 19 +/- 1 mg/dL, P <.05) due to increased low-density lipoprotein catabolism (fractional catabolic rate = 1.7 +/- 0.1 d(-1) in controls vs 4.2 +/- 0.3 d(-1) in LCAT-treated group, P <.05). In summary, overexpression of I-CAT in nonhuman primates leads to an antiatherogenic lipoprotein profile by increasing HDL cholesterol and lowering ApoB, thus making, LCAT a potential drug target for reducing atherosclerosis. Published by Elsevier Inc.
C1 [Amar, Marcelo J. A.; Shamburek, Robert D.; Vaisman, Boris; Knapper, Cathenine L.; Foger, Bernhard; Hoyt, Robert F., Jr.; Santamarina-Fojo, Silvia; Brewer, Hollis B., Jr.; Remaley, Alan T.] NHLBI, Lipoprot Metab Sect, NIH, Bethesda, MD 20892 USA.
RP Amar, MJA (reprint author), NHLBI, Lipoprot Metab Sect, NIH, Bethesda, MD 20892 USA.
EM mamar@mail.nih.gov
FU National Heart, Lung, and Blood Institute at the National Institute's of
Health
FX This work was supported by the intramural funds from the National Heart,
Lung, and Blood Institute at the National Institute's of Health.
NR 54
TC 19
Z9 22
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2009
VL 58
IS 4
BP 568
EP 575
DI 10.1016/j.metabol.2008.11.019
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 429QV
UT WOS:000264936100021
PM 19303980
ER
PT J
AU Li, M
Craigie, R
AF Li, Min
Craigie, Robert
TI Nucleoprotein complex intermediates in HIV-1 integration
SO METHODS
LA English
DT Article
DE Site-specific recombination; Retrovirus; Integrase; Integration;
Nucleoprotein complex
ID VIRUS TYPE-1 INTEGRASE; DNA INTEGRATION; CONCERTED INTEGRATION; IN-VITRO
AB Integration of retroviral DNA into the host genome is an essential step in the viral replication cycle. The viral DNA, made by reverse transcription in the cytoplasm, forms part of a large nucleoprotein complex called the preintegration complex (PIC). The viral integrase protein is the enzyme within the PIC that is responsible for integrating the viral DNA into the host genome. Integrase is tightly associated with the viral DNA within the PIC as demonstrated by functional assays. Integrase protein catalyzes the key DNA cutting and joining steps of integration in vitro with DNA substrates that mimic the ends of the viral DNA. Under most in vitro assay conditions the stringency of the reaction is relaxed; most products result from "half-site" integration in which only one viral DNA end is integrated into one strand of target DNA rather than concerted integration of pairs of DNA as Occurs With PICs and in vivo. Under these relaxed conditions catalysis appears to Occur without formation of the highly stable nucleoprotein complexes that is characteristic of the association of integrase with viral DNA in the PIC. Here we describe methods for the assembly of nucleoprotein complex intermediates in HIV-1 DNA integration from purified HIV-1 integrase and substrates that mimic the viral DNA ends. (C) 2009 Published by Elsevier Inc.
C1 [Li, Min; Craigie, Robert] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Craigie, R (reprint author), NIDDK, Mol Biol Lab, NIH, Bldg 5,Room 301,5 Ctr Dr MSC 0560, Bethesda, MD 20892 USA.
EM bobc@helix.nih.gov
FU Intramural Research Program of the National Institute of Diabetes and
Digestive and Kidney Diseases; NIH AIDS Targeted Antiviral Program
FX This work was supported by the Intramural Research Program of the
National Institute of Diabetes and Digestive and Kidney Diseases and by
the NIH AIDS Targeted Antiviral Program.
NR 13
TC 18
Z9 18
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
J9 METHODS
JI Methods
PD APR
PY 2009
VL 47
IS 4
BP 237
EP 242
DI 10.1016/j.ymeth.2009.02.001
PG 6
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 442AR
UT WOS:000265812600003
PM 19232539
ER
PT J
AU O'Shea, JJ
Steward-Tharp, SM
Laurence, A
Watford, WT
Wei, L
Adamson, AS
Fan, S
AF O'Shea, John J.
Steward-Tharp, Scott M.
Laurence, Arian
Watford, Wendy T.
Wei, Lai
Adamson, Adewole S.
Fan, Samuel
TI Signal transduction and Th17 cell differentiation
SO MICROBES AND INFECTION
LA English
DT Review
DE Th17; IL-17; Signal transduction; Transcription factor; Lymphocyte
differentiation; Cytokines; Chromatin
ID ARYL-HYDROCARBON RECEPTOR; ROR-GAMMA-T; INTERFERON-REGULATORY FACTOR-4;
GROWTH-FACTOR-BETA; COLLAGEN-INDUCED ARTHRITIS; HELPER TYPE-1 CELLS;
HYPER-IGE SYNDROME; TGF-BETA; RETINOIC-ACID; CUTTING EDGE
AB The paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been notably shaken by the discovery of a third lineage of cells that selectively produce interleukin (IL)-17. Characterization of this new subset, referred to as Th17, has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases. Additionally, the discovery of this T cell subset has offered a fresh look at such concepts as lineage commitment and terminal differentiation. The transcriptional regulatory events and epigenetic modifications that control these processes are diverse and complex, and despite the rapid pace at which data continue to accumulate, many questions remain to be answered. Here we review our current understanding of the signaling pathways, molecular interactions and transcriptional events that lead to Th17 differentiation and effector function, as well as the epigenetic modifications that accompany them. Published by Elsevier Masson SAS.
C1 [O'Shea, John J.; Steward-Tharp, Scott M.; Laurence, Arian; Watford, Wendy T.; Wei, Lai; Adamson, Adewole S.; Fan, Samuel] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
[Steward-Tharp, Scott M.] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20814 USA.
[Adamson, Adewole S.] Harvard Mit Div Hlth Sci & Technol, Boston, MA 02115 USA.
[Fan, Samuel] Bradley Univ, Dept Biol, Peoria, IL 61625 USA.
RP Steward-Tharp, SM (reprint author), 10 Ctr Dr,RM 13C103, Bethesda, MD 20892 USA.
EM stewardtharpsm@mail.nih.gov
RI Laurence, Arian/A-8770-2009; Wei, Lai/D-1088-2014
OI Laurence, Arian/0000-0003-0942-8292;
FU Clinical Research Training Program; NIH [1K22 AR053953-01]; Pfizer Inc
FX A.S.A. is funded through the Clinical Research Training Program, a
public-private partnership supported jointly by the NIH and Pfizer Inc
(via a grant to the Foundation for NIH from Pfizer Inc). W.T.W. is
supported by NIH grant 1K22 AR053953-01.
NR 142
TC 26
Z9 29
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1286-4579
J9 MICROBES INFECT
JI Microbes Infect.
PD APR
PY 2009
VL 11
IS 5
BP 599
EP 611
DI 10.1016/j.micinf.2009.04.007
PG 13
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 468RZ
UT WOS:000267839100010
PM 19379825
ER
PT J
AU Narbonne-Reveau, K
Lilly, M
AF Narbonne-Reveau, Karine
Lilly, Mary
TI The Cyclin-dependent Kinase Inhibitor Dacapo Promotes Genomic Stability
during Premeiotic S Phase
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Article
ID REDUCTIONAL CHROMOSOME SEGREGATION; DROSOPHILA-MELANOGASTER FEMALES;
ORIGIN RECOGNITION COMPLEX; GERMLINE CYST FORMATION; CELL NUCLEAR
ANTIGEN; DNA-REPLICATION; SYNAPTONEMAL COMPLEX; DOWN-REGULATION;
RE-REPLICATION; PROTEIN
AB The proper execution of premeiotic S phase is essential to both the maintenance of genomic integrity and accurate chromosome segregation during the meiotic divisions. However, the regulation of premeiotic S phase remains poorly defined in metazoa. Here, we identify the p21(Cip1)/p27(Kip1)/p57(Kip2)-like cyclin-dependent kinase inhibitor (CKI) Dacapo (Dap) as a key regulator of premeiotic S phase and genomic stability during Drosophila oogenesis. In dap(-/-) females, ovarian cysts enter the meiotic cycle with high levels of Cyclin E/cyclin-dependent kinase (Cdk) 2 activity and accumulate DNA damage during the premeiotic S phase. High Cyclin E/Cdk2 activity inhibits the accumulation of the replication-licensing factor Doubleparked/Cdt1 (Dup/Cdt1). Accordingly, we find that dap(-/-) ovarian cysts have low levels of Dup/Cdt1. Moreover, mutations in dup/cdt1 dominantly enhance the dap(-/-) DNA damage phenotype. Importantly, the DNA damage observed in dap(-/-) ovarian cysts is independent of the DNA double-strands breaks that initiate meiotic recombination. Together, our data suggest that the CKI Dap promotes the licensing of DNA replication origins for the premeiotic S phase by restricting Cdk activity in the early meiotic cycle. Finally, we report that dap(-/-) ovarian cysts frequently undergo an extramitotic division before meiotic entry, indicating that Dap influences the timing of the mitotic/meiotic transition.
C1 [Narbonne-Reveau, Karine; Lilly, Mary] NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
RP Lilly, M (reprint author), NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
EM mlilly@helix.nih.gov
OI Lilly, Mary/0000-0003-1564-619X
FU Eunice Kennedy-Shriver National Institute of Child Health and Human
Development at the National Institutes of Health
FX We thank Michael Botchan, Ron Dubreuil, Bob Glaser, R. Scott Hawley, Kim
McKim, Terry Orr-Weaver, Helena Richardson, the Developmental Hybridoma
Bank, and the Bloomington Stock Center for Drosophila stocks and
antibodies. We also thank Eva Decotto and Michael Lichten for comments
on the manuscript. This research was supported by the Intramural
Research Program of the Eunice Kennedy-Shriver National Institute of
Child Health and Human Development at the National Institutes of Health.
NR 68
TC 8
Z9 10
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PD APR
PY 2009
VL 20
IS 7
BP 1960
EP 1969
DI 10.1091/mbc.E08-09-0916
PG 10
WC Cell Biology
SC Cell Biology
GA 427AO
UT WOS:000264752100007
PM 19211840
ER
PT J
AU Alfano, RW
Leppla, SH
Liu, SH
Bugge, TH
Meininger, CJ
Lairmore, TC
Mulne, AF
Davis, SH
Duesbery, NS
Frankel, AE
AF Alfano, Randall W.
Leppla, Stephen H.
Liu, Shihui
Bugge, Thomas H.
Meininger, Cynthia J.
Lairmore, Terry C.
Mulne, Arlynn F.
Davis, Samuel H.
Duesbery, Nicholas S.
Frankel, Arthur E.
TI Matrix Metalloproteinase-Activated Anthrax Lethal Toxin Inhibits
Endothelial Invasion and Neovasculature Formation during In vitro
Morphogenesis
SO MOLECULAR CANCER RESEARCH
LA English
DT Article
ID GROWTH-FACTOR; KINASE-KINASE; TUMOR-GROWTH; MAP KINASES; ANGIOGENESIS;
CELLS; RECEPTOR; RAS; ERK; VASCULARIZATION
AB Solid tumor growth is dependent on angiogenesis, the formation of neovasculature from existing vessels. Endothelial activation of the extracellular signal-regulated kinase 1/2, c-jun NH(2)-terminal kinase, and p38 mitogen-activated protein kinase pathways is central to this process, and thus presents an attractive target for the development of angiogenesis inhibitors. Anthrax lethal toxin (LeTx) has potent catalytic mitogen-activated protein kinase inhibition activity. Preclinical studies showed that LeTx induced potent tumor growth inhibition via the inhibition of xenograft vascularization. However, LeTx receptors and the essential furin-like activating proteases are expressed in many normal tissues, potentially limiting the specificity of LeTx as an antitumor agent. To circumvent nonspecific LeTx activation and simultaneously enhance tumor vascular targeting, a substrate preferably cleaved by the gelatinases class of matrix metalloproteinases (MMP) was substituted for the furin LeTx activation site. In vivo efficacy studies showed that this MMP-activated LeTx inhibited tumor xenografts growth via the reduced migration of endothelial cells into the tumor parenchyma. Here we have expanded on these initial findings by showing that this MMP-activated LeTx reduces endothelial proangiogenic MMP expression, thus causing a diminished proteolytic capacity for extracellular matrix remodeling and endothelial differentiation into capillary networks. Additionally, our data suggest that inhibition of the c-jun NH2-terminal kinase and p38, but not extracellular signal-regulated kinase-1/2, pathways is significant in the antiangiogenic activity of the MMP-activated LeTx. Collectively, these results support the clinical development of the MMP-activated LeTx for the treatment of solid tumors. (Mol Cancer Res 2009;7(4):452-61)
C1 [Alfano, Randall W.; Frankel, Arthur E.] Scott & White Mem Hosp & Clin, Canc Res Inst, Temple, TX 76508 USA.
[Lairmore, Terry C.] Scott & White Mem Hosp & Clin, Dept Surg Oncol, Temple, TX 76508 USA.
[Mulne, Arlynn F.; Davis, Samuel H.] Scott & White Mem Hosp & Clin, Dept Pediat Hematol Oncol, Temple, TX 76508 USA.
[Alfano, Randall W.; Frankel, Arthur E.] Texas A&M Hlth Sci Ctr, Dept Internal Med, Temple, TX USA.
[Meininger, Cynthia J.] Texas A&M Hlth Sci Ctr, Dept Syst Biol & Translat Med, Temple, TX USA.
[Leppla, Stephen H.; Liu, Shihui] NIAID, Lab Bacterial Dis, Bethesda, MD 20892 USA.
[Bugge, Thomas H.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD USA.
[Duesbery, Nicholas S.] Van Andel Res Inst, Lab Canc & Dev Cell Biol, Grand Rapids, MI USA.
RP Frankel, AE (reprint author), Canc Res Inst Scott & White, 5701 S Airport Rd, Temple, TX 76502 USA.
EM afrankel@swmail.sw.org
OI DUESBERY, NICK/0000-0002-4258-5655
FU Scott & White Memorial Hospital
FX Departments of Surgery and Pediatric Hematology/Oncology of Scott &
White Memorial Hospital.
NR 33
TC 12
Z9 12
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1541-7786
J9 MOL CANCER RES
JI Mol. Cancer Res.
PD APR
PY 2009
VL 7
IS 4
BP 452
EP 461
DI 10.1158/1541-7786.MCR-08-0451
PG 10
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA 435CY
UT WOS:000265322400002
PM 19372576
ER
PT J
AU McCord, AM
Jamal, M
Shankavarum, UT
Lang, FF
Camphausen, K
Tofilon, PJ
AF McCord, Amy M.
Jamal, Muhammad
Shankavarum, Uma T.
Lang, Frederick F.
Camphausen, Kevin
Tofilon, Philip J.
TI Physiologic Oxygen Concentration Enhances the Stem-Like Properties of
CD133(+) Human Glioblastoma Cells In vitro
SO MOLECULAR CANCER RESEARCH
LA English
DT Article
ID HYPOXIA-INDUCIBLE FACTORS; TUMOR-INITIATING CELLS; HUMAN BRAIN-TUMORS;
LOWERED OXYGEN; CNS PRECURSORS; CANCER; IDENTIFICATION; DIFFERENTIATION;
EXPRESSION; PHENOTYPE
AB In vitro investigations of tumor stem-like cells (TSC) isolated from human glioblastoma (GB) surgical specimens have been done primarily at an atmospheric oxygen level of 20%. To determine whether an oxygen level more consistent with in situ conditions affects their stem cell-like characteristics, we compared GB TSCs grown under conditions of 20% and 7% oxygen. Growing CD133(+) cells sorted from three GB neurosphere cultures at 7% O-2 reduced their doubling time and increased the self-renewal potential as reflected by clonogenicity. Furthermore, at 7% oxygen, the cultures exhibited an enhanced capacity to differentiate along both the glial and neuronal pathways. As compared with 20%, growth at 7% oxygen resulted in an increase in the expression levels of the neural stem cell markers CD133 and nestin as well as the stem cell markers Oct4 and Sox2. In addition, whereas hypoxia inducible factor la was not affected in CD133(+) TSCs grown at 7% O-2, hypoxia-inducible factor 2 alpha was expressed at higher levels as compared with 20% oxygen. Gene expression profiles generated by microarray analysis revealed that reducing oxygen level to 7% resulted in the up-regulation and down-regulation of a significant number of genes, with more than 140 being commonly affected among the three CD133(+) cultures. Furthermore, Gene Ontology categories up-regulated at 7% oxygen included those associated with stem cells or GB TSCs. Thus, the data presented indicate that growth at the more physiologically relevant oxygen level of 7% enhances the stern cell-like phenotype of CD133(+) GB cells. (Mol Cancer Res 2009;7(4):489-97)
C1 [McCord, Amy M.; Jamal, Muhammad; Tofilon, Philip J.] H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, Tampa, FL 33612 USA.
[Shankavarum, Uma T.; Camphausen, Kevin] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
[Lang, Frederick F.] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA.
RP Tofilon, PJ (reprint author), H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, 12902 Magnolia Dr,SRB3-DRDIS, Tampa, FL 33612 USA.
EM philip.tofilon@moffitt.org
FU National Cancer Institute
FX Cancer Center Support Grant to Moffitt Cancer Center from the National
Cancer Institute
NR 49
TC 138
Z9 142
U1 0
U2 7
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1541-7786
J9 MOL CANCER RES
JI Mol. Cancer Res.
PD APR
PY 2009
VL 7
IS 4
BP 489
EP 497
DI 10.1158/1541-7786.MCR-08-0360
PG 9
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA 435CY
UT WOS:000265322400005
PM 19372578
ER
PT J
AU Lorenzi, PL
Reinhold, WC
Varma, S
Hutchinson, AA
Pommier, Y
Chanock, SJ
Weinstein, JN
AF Lorenzi, Philip L.
Reinhold, William C.
Varma, Sudhir
Hutchinson, Amy A.
Pommier, Yves
Chanock, Stephen J.
Weinstein, John N.
TI DNA fingerprinting of the NCI-60 cell line panel
SO MOLECULAR CANCER THERAPEUTICS
LA English
DT Article
ID L-ASPARAGINASE ACTIVITY; ANTICANCER DRUG SCREEN; OVARIAN-CANCER;
PREDICTIVE BIOMARKER; EXPRESSION PROFILES; MARKER CHROMOSOMES;
CONTAMINATION; MUTATION; SENSITIVITY; SYNTHETASE
AB The National Cancer Institute's NCI-60 cell line panel, the most extensively characterized set of cells in existence and a public resource, is frequently used as a screening tool for drug discovery. Because many laboratories around the world rely on data from the NCI-60 cells, confirmation of their genetic identities represents an essential step in validating results from them. Given the consequences of cell line contamination or misidentification, quality control measures should routinely include DNA fingerprinting. We have, therefore, used standard DNA microsatellite short tandem repeats to profile the NCI-60, and the resulting DNA fingerprints are provided here as a reference. Consistent with previous reports, the fingerprints suggest that several NCI-60 lines have common origins: the melanoma lines MDA-MB-435, MDA-N, and M14; the central nervous system lines U251 and SNB-19; the ovarian lines OVCAR-8 and OVCAR-8/ADR (also called NCI/ADR); and the prostate lines DU-145, DU-145 (ATCC), and RC0.1. Those lines also show that the ability to connect two fingerprints to the same origin is not affected by stable transfection or by the development of multidrug resistance. As expected, DNA fingerprints were not able to distinguish different tissues-of-origin. The fingerprints serve principally as a barcodes. [Mol Cancer Ther 2009;8(4): 713-24]
C1 [Weinstein, John N.] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
[Lorenzi, Philip L.; Reinhold, William C.; Varma, Sudhir; Pommier, Yves; Weinstein, John N.] NCI, Genom & Bioinformat Grp, Mol Pharmacol Lab, CCR,NIH, Bethesda, MD 20892 USA.
[Hutchinson, Amy A.] NCI, Core Genotyping Facil, Div Canc Epidemiol & Genet, Adv Technol Program,SAIC Frederick Inc, Frederick, MD 21701 USA.
[Hutchinson, Amy A.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
RP Weinstein, JN (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM jweinste@mdanderson.org
RI Varma, Sudhir/N-8763-2014
OI Varma, Sudhir/0000-0002-4096-4782
FU NIH; National Cancer Institute, Center for Cancer Research
[N01-CO-12400]; NIGMS
FX Intramural Research Program of the NIH, National Cancer Institute,
Center for Cancer Research, and in part under contract N01-CO-12400.
PILL is supported by a Pharmacology Research Associate Fellowship from
NIGMS, NIH.
NR 31
TC 80
Z9 82
U1 1
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1535-7163
J9 MOL CANCER THER
JI Mol. Cancer Ther.
PD APR
PY 2009
VL 8
IS 4
BP 713
EP 724
DI 10.1158/1535-7163.MCT-08-0921
PG 12
WC Oncology
SC Oncology
GA 433LE
UT WOS:000265204500001
PM 19372543
ER
PT J
AU Li, Q
Anver, MR
Butcher, DO
Gildersleeve, JC
AF Li, Qian
Anver, Miriam R.
Butcher, Donna O.
Gildersleeve, Jeffrey C.
TI Resolving conflicting data on expression of the Tn antigen and
implications for clinical trials with cancer vaccines
SO MOLECULAR CANCER THERAPEUTICS
LA English
DT Article
ID POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; CARCINOMA-ASSOCIATED TN;
SIALOSYL-TN; BLOOD-GROUP; MALIGNANT TRANSFORMATION; CARBOHYDRATE
MICROARRAYS; MONOCLONAL-ANTIBODIES; COLORECTAL-CANCER; SYNTHETIC
VACCINE; IMMUNE-RESPONSES
AB The tumor-associated Tn antigen has been investigated extensively as a biomarker and therapeutic target. Cancer vaccines containing the Tin antigen as a single tumor antigen or as a component of a polyvalent vaccine have progressed into phase I and II clinical trials. One major focus of Tn-based vaccines is the treatment of prostate cancer patients. Although expression of the antigen on prostate tumors is a critical prerequisite, previous reports investigating Tn expression in prostate tumors have produced conflicting results. Using a combination of immunohistochemistry and carbohydrate microarray profiling, we show that only 4% to 26% of prostate tumors express the Tn antigen. Based on our results, the majority of prostate cancer patients do not express the appropriate antigen. Therefore, efforts to preselect the subset of prostate cancer patients with Tn-positive tumors or apply Tin vaccines to other cancers with higher rates of antigen expression could significantly improve clinical response rates. Because conflicting information on carbohydrate expression is a general problem for the field, the approach described in this article of analyzing antigen expression with multiple antibodies and using carbohydrate microarray profiles to interpret the results will be useful for the development of other carbohydrate-based cancer vaccines and diagnostics. [Mol Cancer Ther 2009;8(4):971-9]
C1 [Li, Qian; Gildersleeve, Jeffrey C.] NCI, Med Chem Lab, Ctr Canc Res, Frederick, MD 21702 USA.
[Anver, Miriam R.; Butcher, Donna O.] NCI, Lab Anim Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA.
RP Gildersleeve, JC (reprint author), NCI, Med Chem Lab, Ctr Canc Res, Bldg 376,Room 109,376 Boyles St, Frederick, MD 21702 USA.
EM gildersleevej@ncifcrf.gov
RI Gildersleeve, Jeffrey/N-3392-2014
FU NIH, National Cancer Institute Intramural Research Program; NIH,
National Cancer Institute [N01-CO-12400]
FX NIH, National Cancer Institute Intramural Research Program and NIH,
National Cancer Institute contract N01-CO-12400.
NR 50
TC 37
Z9 37
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1535-7163
J9 MOL CANCER THER
JI Mol. Cancer Ther.
PD APR
PY 2009
VL 8
IS 4
BP 971
EP 979
DI 10.1158/1535-7163.MCT-08-0934
PG 9
WC Oncology
SC Oncology
GA 433LE
UT WOS:000265204500028
PM 19372570
ER
PT J
AU Hagenblad, J
Olsson, M
Parker, HG
Ostrander, EA
Ellegren, H
AF Hagenblad, Jenny
Olsson, Maria
Parker, Heidi G.
Ostrander, Elaine A.
Ellegren, Hans
TI Population genomics of the inbred Scandinavian wolf
SO MOLECULAR ECOLOGY
LA English
DT Article
DE conservation genetics; genome scan; heterozygosity; inbreeding; linkage
disequilibrium
ID CANIS-LUPUS POPULATION; LINKAGE DISEQUILIBRIUM; INBREEDING DEPRESSION;
DOMESTIC DOG; NATURAL-POPULATIONS; GENETIC-BASIS; NUCLEOTIDE
POLYMORPHISM; CHROMOSOME; MARKERS; IDENTIFICATION
AB The Scandinavian wolf population represents one of the genetically most well-characterized examples of a severely bottlenecked natural population (with only two founders), and of how the addition of new genetic material (one immigrant) can at least temporarily provide a 'genetic rescue'. However, inbreeding depression has been observed in this population and in the absence of additional immigrants, its long-term viability is questioned. To study the effects of inbreeding and selection on genomic diversity, we performed a genomic scan with approximately 250 microsatellite markers distributed across all autosomes and the X chromosome. We found linkage disequilibrium (LD) that extended up to distances of 50 Mb, exceeding that of most outbreeding species studied thus far. LD was particularly pronounced on the X chromosome. Overall levels of observed genomic heterozygosity did not deviate significantly from simulations based on known population history, giving no support for a general selection for heterozygotes. However, we found evidence supporting balancing selection at a number of loci and also evidence suggesting directional selection at other loci. For markers on chromosome 23, the signal of selection was particularly strong, indicating that purifying selection against deleterious alleles may have occurred even in this very small population. These data suggest that population genomics allows the exploration of the effects of neutral and non-neutral evolution on a finer scale than what has previously been possible.
C1 [Hagenblad, Jenny] Linkoping Univ, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
[Hagenblad, Jenny] Uppsala Univ, Dept Plant Ecol, Evolutionary Biol Ctr, SE-75236 Uppsala, Sweden.
[Parker, Heidi G.; Ostrander, Elaine A.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Hagenblad, Jenny; Olsson, Maria; Ellegren, Hans] Uppsala Univ, Evolutionary Biol Ctr, Dept Evolutionary Biol, SE-75236 Uppsala, Sweden.
RP Ellegren, H (reprint author), Linkoping Univ, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
EM Hans.Ellegren@ebc.uu.se
OI Hagenblad, Jenny/0000-0002-9850-5546; Ostrander,
Elaine/0000-0001-6075-9738
FU Norwegian and Swedish Environmental Protection Agencies; National Human
Genome Research Institute of the National Institutes of Health
FX Financial support was obtained from the Norwegian and Swedish
Environmental Protection Agencies. Three anonymous reviewers are
acknowledged for helpful comments. J.H. acknowledges Mats Aigner for
help with computer programming and the Ewens-Watterson test. E.A.O. and
H.G.P. acknowledge the Intramural Program of the National Human Genome
Research Institute of the National Institutes of Health.
NR 49
TC 23
Z9 24
U1 8
U2 68
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1083
EI 1365-294X
J9 MOL ECOL
JI Mol. Ecol.
PD APR
PY 2009
VL 18
IS 7
BP 1341
EP 1351
DI 10.1111/j.1365-294X.2009.04120.x
PG 11
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
Evolutionary Biology
GA 421QR
UT WOS:000264373900004
PM 19368642
ER
PT J
AU Takikita, S
Myerowitz, R
Zaal, K
Raben, N
Plotz, PH
AF Takikita, Shoichi
Myerowitz, Rachel
Zaal, Kristien
Raben, Nina
Plotz, Paul H.
TI Murine muscle cell models for Pompe disease and their use in studying
therapeutic approaches
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Article
DE Autophagy; Lysosomes; Myotubes; Pompe disease
ID ACID ALPHA-GLUCOSIDASE; LYSOSOMAL STORAGE DISEASE; SKELETAL-MUSCLE;
PROTON PUMP; AUTOPHAGY; GLYCOGEN; ENZYME; MICE; DEGRADATION; SENESCENCE
AB Lysosomes filled with glycogen are a major pathologic feature of Pompe disease, a fatal myopathy and cardiomyopathy caused by a deficiency of the glycogen-degrading lysosomal enzyme, acid alpha-glucosidase (GAA). To facilitate Studies germane to this genetic disorder, we developed two in vitro Pompe models: myotubes derived from cultured primary myoblasts isolated from Pompe (GAA KO) mice, and myotubes derived from primary myoblasts of the same genotype that had been transduced with cyclin-dependent kinase 4 (CDK4). This latter model is endowed with extended proliferative capacity. Both models showed extremely large alkalinized, glycogen-filled lysosomes as well as impaired trafficking to lysosomes. Although both Pompe tissue culture models were derived from fast muscles and were fast myosin positive, they strongly resemble slow fibers in terms of their pathologic phenotype and their response to therapy with recombinant human GAA (rhGAA). Autophagic buildup, a hallmark of Pompe disease in fast muscle fibers, was absent, but basal autophagy was functional. To evaluate substrate deprivation as a strategy to Prevent the accumulation of lysosomal glycogen, we knocked down Atg7, a gene essential for autophagosome formation, via siRNA, but we observed no effect on the extent of glycogen accumulation, thus confirming our recent observation in autophagy-deficient Pompe mice [N. Raben, V. Hill, L. Shea, S. Takikita, R. Baum, N. Mizushima, E. Ralston, P. Plotz, Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease, Hum. Mol. Genet. 17 (2008) 3897-3908] that macroautophagy is not the major route of glycogen transport to lysosomes. The in vitro Pompe models Should be useful in addressing fundamental questions regarding the pathway of glycogen to the lysosomes and testing panels of small molecules that could affect glycogen biosynthesis or speed delivery of the replacement enzyme to affected lysosomes. Published by Elsevier Inc.
C1 [Takikita, Shoichi; Myerowitz, Rachel; Raben, Nina; Plotz, Paul H.] NIAMSD, Arthritis & Rheumatism Branch, NIH, Bethesda, MD 20892 USA.
[Myerowitz, Rachel] St Marys Coll Maryland, St Marys City, MD 20686 USA.
[Zaal, Kristien] NIAMSD, Light Imaging Sect, Off Sci & Technol, NIH, Bethesda, MD 20892 USA.
RP Takikita, S (reprint author), NIAMSD, Arthritis & Rheumatism Branch, NIH, Bldg 50 Room 1345,50 S Dr, Bethesda, MD 20892 USA.
EM takikitas@mail.nih.gov
FU NIH (National Institute of Arthritis and Musculoskeletal and Skin
Diseases [NIAMS]); CRADA
FX This research was supported by the Intramural Research Program of the
NIH (National Institute of Arthritis and Musculoskeletal and Skin
Diseases [NIAMS]). Dr. Takikita and Dr. Myerowitz were supported in part
by a CRADA between the NIH and Genzyme Corporation.
NR 32
TC 15
Z9 16
U1 1
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD APR
PY 2009
VL 96
IS 4
BP 208
EP 217
DI 10.1016/j.ymgme.2008.12.012
PG 10
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 426VZ
UT WOS:000264737700010
PM 19167256
ER
PT J
AU Simkus, C
Makiya, M
Jones, JM
AF Simkus, Carrie
Makiya, Michelle
Jones, Jessica M.
TI Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase
SO MOLECULAR IMMUNOLOGY
LA English
DT Article
DE V(D)J recombination; Ubiquitin ligase; RAG1; KPNA1; Karyopherin alpha 1;
SRP1
ID V(D)J RECOMBINATION ACTIVITY; B-CELL; LYMPHOCYTE DEVELOPMENT;
PROTEIN-DEGRADATION; IMPORTIN-ALPHA; RING DOMAIN; BINDING; TRANSPORT;
RECEPTOR; COMPLEX
AB The RAG1 recombinase, which participates in DNA manipulation during rearrangement of antigen receptor genes in developing immune cells, possesses ubiquitin ligase activity. The nuclear transport protein karyopherin alpha 1 (KPNA1) binds to RAG1 upstream of its ubiquitin ligase domain, but this interaction is not required for nuclear localization of RAG1. We found that the isolated ubiquitin ligase domain of RAG1 (amino acids 218-389) promoted ubiquitylation of purified KPNA1. While RAG1 auto-ubiquitylation is dependent on the ubiquitin conjugating enzyme CDC34, ubiquitylation of KPNA1 was best supported by UbcH2/Rad6 and UbcH5a. Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1. This is the first putative substrate identified for the RAG1 ubiquitin ligase, and to our knowledge it is the first reported case of ubiquitylation of KPNA1. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Simkus, Carrie; Jones, Jessica M.] Georgetown Univ, Dept Biochem & Mol & Cellular Sci, Washington, DC 20057 USA.
[Makiya, Michelle] NIAID, NIH, Bethesda, MD 20892 USA.
RP Jones, JM (reprint author), Georgetown Univ, Dept Biochem & Mol & Cellular Sci, Basic Sci Bldg Room 323,3900 Reservoir Rd NW, Washington, DC 20057 USA.
EM jonesj5@georgetown.edu
FU National Cancer Institute; National Institutes of Health [P30CA051008,
AI062854-01]
FX This project has been funded in whole or in part with federal funds from
the National Cancer Institute, National Institutes of Health, under
Award Number P30CA051008. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the United States
Government. This project was supported in part by a grant to J.M.J. from
the National Institutes of Health (AI062854-01). The content is solely
the responsibility of the authors.
NR 54
TC 18
Z9 20
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0161-5890
J9 MOL IMMUNOL
JI Mol. Immunol.
PD APR
PY 2009
VL 46
IS 7
BP 1319
EP 1325
DI 10.1016/j.molimm.2008.11.009
PG 7
WC Biochemistry & Molecular Biology; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA 435CS
UT WOS:000265321600006
PM 19118899
ER
PT J
AU Adamson, CS
Freed, EO
AF Adamson, Catherine S.
Freed, Eric O.
TI Anti-HIV-1 Therapeutics: From FDA-approved Drugs to Hypothetical Future
Targets
SO MOLECULAR INTERVENTIONS
LA English
DT Editorial Material
ID SMALL-MOLECULE INHIBITION; HIV-1 CAPSID PROTEIN; ASSEMBLY INHIBITOR;
ENTRY INHIBITORS; TERMINAL DOMAIN; INTEGRASE; INFECTION; LEDGF/P75;
COMPLEX; REPLICATION
C1 [Adamson, Catherine S.; Freed, Eric O.] NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.
RP Adamson, CS (reprint author), NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.
EM cadamson@ncifcrf.gov; efreed@nih.gov
NR 44
TC 5
Z9 5
U1 0
U2 1
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 1534-0384
J9 MOL INTERV
JI Mol. Interv.
PD APR 1
PY 2009
VL 9
IS 2
BP 70
EP 74
DI 10.1124/mi.9.2.5
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 497TC
UT WOS:000270084300003
PM 19401538
ER
PT J
AU Alkhalil, A
Pillai, AD
Bokhari, AAB
Vaidya, AB
Desai, SA
AF Alkhalil, Abdulnaser
Pillai, Ajay D.
Bokhari, Abdullah A. B.
Vaidya, Akhil B.
Desai, Sanjay A.
TI Complex inheritance of the plasmodial surface anion channel in a
Plasmodium falciparum genetic cross
SO MOLECULAR MICROBIOLOGY
LA English
DT Article
ID RED-BLOOD-CELLS; INFECTED ERYTHROCYTES; MALARIA PARASITE; PERMEABILITY
PATHWAYS; MEMBRANE; RECOMBINATION; RESISTANCE; MODEL; PERMEATION;
DANTROLENE
AB Human erythrocytes infected with the malaria parasite Plasmodium falciparum have increased permeabilities to many solutes. The plasmodial surface anion channel (PSAC) may mediate these changes. Despite good understanding of the biochemical and biophysical properties, the genetic basis of PSAC activity remains unknown. Functional polymorphisms in laboratory isolates and two mutants generated by in vitro selection implicate a parasite-encoded channel, although parasite-induced modifications of endogenous channels have not been formally excluded. Here, we identified stable differences in furosemide efficacy against PSAC activity induced by HB3 and 3D7A parasites. This difference was apparent in both single PSAC patch-clamp recordings and in sorbitol-mediated osmotic lysis measurements, confirming that Cl(-) and sorbitol are transported by a single-channel type. Examination of 19 progeny from a genetic cross between HB3 and 3D7A revealed complex inheritance with some cloned progeny exhibiting furosemide affinities outside the range of parental values. Isolates generated by selfing of the 3D7A clone also exhibited altered furosemide affinities, implicating changes in one or more alleles during meiosis or passage through a primate host. PSAC may be encoded by multiple parasite genes (e.g. a multi-gene family or multiple genes that encode distinct channel subunits) or a single polymorphic gene under strong selective pressure.
C1 [Alkhalil, Abdulnaser; Pillai, Ajay D.; Bokhari, Abdullah A. B.; Desai, Sanjay A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
[Vaidya, Akhil B.] Drexel Univ, Coll Med, Ctr Mol Parasitol, Dept Microbiol & Immunol, Philadelphia, PA 19129 USA.
RP Desai, SA (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
EM sdesai@niaid.nih.gov
RI Desai, Sanjay/B-7110-2009
FU National Institutes of Health, National Institute of Allergy and
Infectious Diseases; Medicines for Malaria Venture (MMV)
FX We thank Tsione Solomon for help with early experiments and Jianbing Mu
for assistance with DNA fingerprinting. This research was supported by
the Intramural Research Program of the National Institutes of Health,
National Institute of Allergy and Infectious Diseases and by the
Medicines for Malaria Venture (MMV).
NR 42
TC 13
Z9 13
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0950-382X
J9 MOL MICROBIOL
JI Mol. Microbiol.
PD APR
PY 2009
VL 72
IS 2
BP 459
EP 469
DI 10.1111/j.1365-2958.2009.06661.x
PG 11
WC Biochemistry & Molecular Biology; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA 430UK
UT WOS:000265014500016
PM 19320831
ER
PT J
AU Lee, DI
Klein, MG
Zhu, WZ
Xiao, RP
Gerzanich, V
Xu, KY
AF Lee, Dong I.
Klein, Michael G.
Zhu, Weizhong
Xiao, Rui-Ping
Gerzanich, Volodymyr
Xu, Kai Y.
TI Activation of (Na(+) + K(+))-ATPase Modulates Cardiac L-Type Ca(2+)
Channel Function
SO MOLECULAR PHARMACOLOGY
LA English
DT Article
ID PROTEIN-KINASE-C; RAT VENTRICULAR MYOCYTES; NA+/K+-ATPASE; CARDIAC
MYOCYTES; CA2+ CHANNELS; SARCOPLASMIC-RETICULUM; CALCIUM;
PHOSPHORYLATION; RELEASE; BINDING
AB Cellular Ca(2+) signaling underlies diverse vital biological processes, including muscle contractility, memory encoding, fertilization, cell survival, and cell death. Despite extensive studies, the fundamental control mechanisms that regulate intracellular Ca(2+) movement remain enigmatic. We have found recently that activation of the (Na(+) + K(+))-ATPase markedly potentiates intracellular Ca(2+) transients and contractility of rat heart cells. Little is known about the pathway responsible for the activation of the (Na(+) + K(+))-ATPase-initiated Ca(2+) signaling. Here, we demonstrate a novel mechanism in which activation of the (Na(+) + K(+))-ATPase is coupled to increased L-type Ca(2+) channel function through a signaling cascade involving Src and ERK1/2 but not well established regulators of the channel, such as adrenergic receptor system or activation of PKA or CaMKII. We have also identified Ser(1928), a phosphorylation site for the alpha 1 subunit of the L-type Ca(2+) channel that may participate in the activation of the (Na(+) + K(+))-ATPase-mediated Ca(2+) signaling. The findings reported here uncover a novel molecular cross-talk between activation of the (Na(+) + K(+))-ATPase and L-type Ca(2+) channel and provide new insights into Ca(2+) signaling mechanisms for deeper understanding of the nature of cellular Ca(2+) handling in heart.
C1 [Xu, Kai Y.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA.
[Gerzanich, Volodymyr] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA.
[Lee, Dong I.; Klein, Michael G.] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA.
[Zhu, Weizhong; Xiao, Rui-Ping] NIA, Gerontol Res Ctr, Cardiovasc Sci Lab, Baltimore, MD 21224 USA.
RP Xu, KY (reprint author), Univ Maryland, Sch Med, Dept Surg, 10 S Pine St,MSTF-434E, Baltimore, MD 21201 USA.
EM kxu002@umaryland.edu
FU National Institutes of Health National Heart, Lung, and Blood Institute
[HL52175]; National Institutes of Health National Institute of Arthritis
and Musculoskeletal and Skin Diseases [AR44197]; National Institutes of
Health National Institute on Aging; Johnson Johnson.
FX This work was supported in part by the National Institutes of Health
National Heart, Lung, and Blood Institute [Grant HL52175]; by the
National Institutes of Health National Institute of Arthritis and
Musculoskeletal and Skin Diseases [Grant AR44197]; by the Intramural
Research program of the National Institutes of Health National Institute
on Aging; and by a seed grant from Johnson & Johnson.
NR 40
TC 11
Z9 11
U1 0
U2 2
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0026-895X
J9 MOL PHARMACOL
JI Mol. Pharmacol.
PD APR
PY 2009
VL 75
IS 4
BP 774
EP 781
DI 10.1124/mol.108.052597
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 420RT
UT WOS:000264307600006
PM 19122004
ER
PT J
AU Nakajima, T
Tanaka, N
Kanbe, H
Hara, A
Kamijo, Y
Zhang, XW
Gonzalez, FJ
Aoyama, T
AF Nakajima, Takero
Tanaka, Naoki
Kanbe, Hiroki
Hara, Atsushi
Kamijo, Yuji
Zhang, Xiaowei
Gonzalez, Frank J.
Aoyama, Toshifumi
TI Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver
Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding
Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor
alpha-Independent Mechanism
SO MOLECULAR PHARMACOLOGY
LA English
DT Article
ID PPAR-ALPHA; SECONDARY PREVENTION; OXYSTEROL RECEPTORS; X-RECEPTOR;
LXR-ALPHA; LIVER; CHOLESTEROL; GENE; HEPATOCARCINOGENESIS; DEHYDROGENASE
AB The triglyceride-lowering effect of bezafibrate in humans has been attributed to peroxisome proliferator-activated receptor (PPAR) alpha activation based on results from rodent studies. However, the bezafibrate dosages used in conventional rodent experiments are typically higher than those in clinical use (>= 50 versus <= 10 mg/kg/day), and thus it remains unclear whether such data can be translated to humans. Furthermore, because bezafibrate is a pan-PPAR activator, the actual contribution of PPAR alpha to its triglyceride-lowering properties remains undetermined. To address these issues, bezafibrate at clinically relevant doses (10 mg/kg/day; low) was administered to wild-type and Ppara-null mice, and its effects were compared with those from conventionally used doses (100 mg/kg/day; high). Pharmacokinetic analyses showed that maximum plasma concentration and area under the concentration-time curve in bezafibrate-treated mice were similar to those in humans at low doses, but not at high doses. Low-dose bezafibrate decreased serum/liver triglycerides in a PPAR alpha-independent manner by attenuation of hepatic lipogenesis and triglyceride secretion. It is noteworthy that instead of PPAR activation, down-regulation of sterol regulatory element-binding protein (SREBP)-1c was observed in mice undergoing low-dose treatment. High-dose bezafibrate decreased serum/liver triglycerides by enhancement of hepatic fatty acid uptake and beta-oxidation via PPAR alpha activation, as expected. In conclusion, clinically relevant doses of bezafibrate exert a triglyceride-lowering effect by suppression of the SREBP-1c-regulated pathway in mice and not by PPAR alpha activation. Our results may provide novel information about the pharmacological mechanism of bezafibrate action and new insights into the treatment of disorders involving SREBP-1c.
C1 [Nakajima, Takero; Tanaka, Naoki; Kanbe, Hiroki; Hara, Atsushi; Kamijo, Yuji; Zhang, Xiaowei; Aoyama, Toshifumi] Shinshu Univ, Grad Sch Med, Inst Aging & Adaptat, Dept Metab Regulat, Matsumoto, Nagano 3908621, Japan.
[Tanaka, Naoki; Kamijo, Yuji] Shinshu Univ, Sch Med, Dept Internal Med, Matsumoto, Nagano 390, Japan.
[Gonzalez, Frank J.] NCI, Lab Metab, Bethesda, MD 20892 USA.
RP Tanaka, N (reprint author), Shinshu Univ, Grad Sch Med, Inst Aging & Adaptat, Dept Metab Regulat, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan.
EM naopi@shinshu-u.ac.jp
RI Hara, Atsushi/B-1127-2008
FU National Institutes of Health National Cancer Institute
FX This research was supported by the Intramural Research Program of the
National Institutes of Health National Cancer Institute.
NR 46
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U1 0
U2 0
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0026-895X
J9 MOL PHARMACOL
JI Mol. Pharmacol.
PD APR
PY 2009
VL 75
IS 4
BP 782
EP 792
DI 10.1124/mol.108.052928
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 420RT
UT WOS:000264307600007
PM 19124612
ER
PT J
AU Shaw, P
Wallace, GL
Addington, A
Evans, A
Rapoport, J
Giedd, JN
AF Shaw, P.
Wallace, G. L.
Addington, A.
Evans, A.
Rapoport, J.
Giedd, J. N.
TI Effects of the Val(158)Met catechol-O-methyltransferase polymorphism on
cortical structure in children and adolescents
SO MOLECULAR PSYCHIATRY
LA English
DT Letter
ID ASSOCIATION; MORPHOMETRY; ADULTS; BRAIN; GENE
C1 [Shaw, P.; Wallace, G. L.; Addington, A.; Rapoport, J.; Giedd, J. N.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[Evans, A.] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
RP Shaw, P (reprint author), NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
EM shawp@mail.nih.gov
RI Giedd, Jay/A-3080-2008; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015;
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978; Wallace,
Gregory/0000-0003-0329-5054
FU Intramural NIH HHS [ZIA MH002794-08]
NR 12
TC 24
Z9 24
U1 1
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2009
VL 14
IS 4
BP 348
EP 349
DI 10.1038/mp.2008.121
PG 2
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 422KG
UT WOS:000264426000001
PM 19308019
ER
PT J
AU Zhang, D
Cheng, L
Qian, Y
Alliey-Rodriguez, N
Kelsoe, JR
Greenwood, T
Nievergelt, C
Barrett, TB
McKinney, R
Schork, N
Smith, EN
Bloss, C
Nurnberger, J
Edenberg, HJ
Foroud, T
Sheftner, W
Lawson, WB
Nwulia, EA
Hipolito, M
Coryell, W
Rice, J
Byerley, W
McMahon, F
Schulze, TG
Berrettini, W
Potash, JB
Belmonte, PL
Zandi, PP
McInnis, MG
Zollner, S
Craig, D
Szelinger, S
Koller, D
Christian, SL
Liu, C
Gershon, ES
AF Zhang, D.
Cheng, L.
Qian, Y.
Alliey-Rodriguez, N.
Kelsoe, J. R.
Greenwood, T.
Nievergelt, C.
Barrett, T. B.
McKinney, R.
Schork, N.
Smith, E. N.
Bloss, C.
Nurnberger, J.
Edenberg, H. J.
Foroud, T.
Sheftner, W.
Lawson, W. B.
Nwulia, E. A.
Hipolito, M.
Coryell, W.
Rice, J.
Byerley, W.
McMahon, F.
Schulze, T. G.
Berrettini, W.
Potash, J. B.
Belmonte, P. L.
Zandi, P. P.
McInnis, M. G.
Zoellner, S.
Craig, D.
Szelinger, S.
Koller, D.
Christian, S. L.
Liu, C.
Gershon, E. S.
TI Singleton deletions throughout the genome increase risk of bipolar
disorder
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE copy number variation; singleton; bipolar disorder; genetics
ID WIDE ASSOCIATION; COPY NUMBER; SCHIZOPHRENIA; LINKAGE; AUTISM; GENES;
LOCI; PCR
AB An overall burden of rare structural genomic variants has not been reported in bipolar disorder ( BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome-wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix single nucleotide polymorphism ( SNP) 6.0 SNP and CNV platform. Singleton deletions ( deletions that appear only once in the dataset) more than 100 kb in length are present in 16.2% of BD cases in contrast to 12.3% of controls ( permutation P = 0.007). This effect was more pronounced for age at onset of mania <= 18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants.
C1 [Zhang, D.; Cheng, L.; Qian, Y.; Alliey-Rodriguez, N.; Liu, C.; Gershon, E. S.] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
[Kelsoe, J. R.; Greenwood, T.; Nievergelt, C.; Barrett, T. B.; McKinney, R.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Schork, N.; Smith, E. N.; Bloss, C.] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA.
[Schork, N.; Smith, E. N.; Bloss, C.] Scripps Genom Med & Scripps Translat Sci Inst, La Jolla, CA USA.
[Nurnberger, J.; Koller, D.] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
[Edenberg, H. J.] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN USA.
[Edenberg, H. J.; Foroud, T.] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Sheftner, W.] Rush Univ, Dept Psychiat, Chicago, IL 60612 USA.
[Lawson, W. B.; Nwulia, E. A.; Hipolito, M.] Howard Univ, Dept Psychiat, Washington, DC 20059 USA.
[Coryell, W.] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA.
[Rice, J.] Washington Univ, Div Biostat, St Louis, MO USA.
[Byerley, W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
[McMahon, F.; Schulze, T. G.] NIMH, Genet Basis Mood & Anxiety Disorders Unit, Intramural Res Program, NIH,US Dept Hlth & Human Serv, Bethesda, MD USA.
[Berrettini, W.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
[Potash, J. B.; Belmonte, P. L.; Zandi, P. P.] Johns Hopkins Sch Med, Dept Psychiat, Baltimore, MD USA.
[McInnis, M. G.; Zoellner, S.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
[Craig, D.; Szelinger, S.] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ USA.
[Christian, S. L.; Gershon, E. S.] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
RP Gershon, ES (reprint author), Univ Chicago, Dept Psychiat & Behav Neurosci, 5841 S Maryland Ave,MC3077, Chicago, IL 60637 USA.
EM cliu@yoda.bsd.uchicago.edu; egershon@yoda.bsd.uchicago.edu
RI Greenwood, Tiffany/F-6356-2012; Liu, Chunyu/G-7561-2012; Smith,
Erin/E-5933-2011; McInnis, Melvin/F-6963-2012; Schulze,
Thomas/H-2157-2013;
OI Greenwood, Tiffany/0000-0002-6080-6503; Liu, Chunyu/0000-0002-5986-4415;
McInnis, Melvin/0000-0002-0375-6247; Lawson,
William/0000-0002-9324-7090; Nurnberger, John/0000-0002-7674-1767;
Nievergelt, Caroline/0000-0001-5766-8923; McMahon,
Francis/0000-0002-9469-305X; Edenberg, Howard/0000-0003-0344-9690
FU NIMH [1R01MH081804-01]; NARSAD; Eklund family; Geraldi Norton Foundation
FX This paper was prepared as part of the bipolar collaboration of the
GAIN, and was submitted before the end of the publication embargo for
non-GAIN scientists. We acknowledge Dr Dan Nicolae (University of
Chicago) for extensive statistical discussion and advice, Mr Xiaotong
Zhang (University of Chicago) for his excellent software support and Ms
Kay Grennan (University of Chicago) for her technical assistance. This
work was supported by grants from 1R01MH081804-01 (NIMH), NARSAD, the
Eklund family and the Geraldi Norton Foundation.
NR 26
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U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2009
VL 14
IS 4
BP 376
EP 380
DI 10.1038/mp.2008.144
PG 5
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 422KG
UT WOS:000264426000007
PM 19114987
ER
PT J
AU Engel, SR
Creson, TK
Hao, Y
Shen, Y
Maeng, S
Nekrasova, T
Landreth, GE
Manji, HK
Chen, G
AF Engel, S. R.
Creson, T. K.
Hao, Y.
Shen, Y.
Maeng, S.
Nekrasova, T.
Landreth, G. E.
Manji, H. K.
Chen, G.
TI The extracellular signal-regulated kinase pathway contributes to the
control of behavioral excitement
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE ERK; neurotrophin; lithium; valproate; mania; depression
ID ELEMENT-BINDING PROTEIN; DEFICIT HYPERACTIVITY DISORDER; FORCED SWIM
TEST; SYNAPTIC PLASTICITY; NEUROTROPHIC FACTOR; MOUSE MODEL; INDUCED
HYPERLOCOMOTION; ANTIDEPRESSANT DRUGS; BIPOLAR DISORDER; MOOD STABILIZER
AB The extracellular signal-regulated kinase (ERK) pathway mediates neuronal plasticity in the CNS. The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK pathway-mediated neurite growth, neuronal survival and hippocampal neurogenesis. Here, we examined the role of the ERK pathway in behavioral plasticity related to facets of bipolar disorder. Mice with ERK1 ablation acquired reduced phosphorylation of RSK1, an ERK substrate, in prefrontal cortex and striatum, but not in hippocampus or cerebellum, indicating the ablation-induced brain region-specific ERK signaling deficits. ERK1 ablation produced a behavioral excitement profile similar to that induced by psychostimulants. The profile is characterized by hyperactivity, enhanced goal-directed activity and increased pleasure-related activity with potential harmful consequence. ERK1-ablated mice were hyperactive in multiple tests and resistant to behavioral despair in the forced swim test. These mice displayed more home-cage voluntary wheel running activities, rearings in a large arena and open-arm visits in an elevated plus maze. Treatments with valproate and olanzapine, but not lithium reduced baseline activities in ERK1-ablated mice. All three treatments attenuated amphetamine-induced hyperactivity in ablated mice. These data indicate a profound involvement of ERK1 signaling in behavioral excitement and in the behavioral action of antimanic agents. The extent to which ERK pathway perturbation contributes to the susceptibility, mood switch mechanism(s) and symptom pathophysiology of bipolar disorder requires further investigation. Whether there is a shared mechanism through which mood stabilizers produce their clinical actions on mood, thought and behavioral symptoms of mania also requires further investigation.
C1 [Engel, S. R.; Creson, T. K.; Hao, Y.; Shen, Y.; Maeng, S.; Manji, H. K.; Chen, G.] NIMH, Mol Pathophysiol Lab, NIH, Bethesda, MD 20892 USA.
[Nekrasova, T.; Landreth, G. E.] Case Western Reserve Univ, Sch Med, Alzheimers Res Lab, Cleveland, OH 44106 USA.
RP Chen, G (reprint author), NIMH, Mol Pathophysiol Lab, NIH, Bldg 35,Rm 1C-912,35 Convent Dr,MSC 3711, Bethesda, MD 20892 USA.
EM guangchen@mail.nih.gov
RI Chen, Guang/A-2570-2017
FU NIMH-IRP; NARSAD
FX This project was supported by funding from NIMH-IRP (Manji and Chen) and
NARSAD ( Chen). The views expressed in this article do not necessarily
represent those of NIMH or NIH or the Federal Government.
NR 74
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U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2009
VL 14
IS 4
BP 448
EP 461
DI 10.1038/sj.mp.4002135
PG 14
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 422KG
UT WOS:000264426000013
PM 18227838
ER
PT J
AU Buxton, DB
AF Buxton, Denis B.
TI Nanomedicine for the management of lung and blood diseases
SO NANOMEDICINE
LA English
DT Article
DE drug delivery; gene therapy; hematopoietic; nanoparticle; pulmonary;
thrombosis
ID HEMATOPOIETIC STEM/PROGENITOR CELLS; ALBUMIN-BOUND PACLITAXEL;
ENGINEERED NANOPARTICLES; PULMONARY DELIVERY; DRUG-DELIVERY;
GENE-THERAPY; SIRNA; DEPOSITION; GEMCITABINE; ADHESION
AB Nanotechnology provides a broad range of opportunities to develop new solutions for clinical problems. For the pulmonary field, nanotechnology promises better delivery of drugs and nucleic acid-based therapeutics to disease sites. Administration of therapeutics via inhalation provides the opportunity for direct delivery to the lung epithelium, the lining of the respiratory tract. By appropriate selection of particle size, deep lung delivery can be obtained with control of phagocytic uptake, the removal of particles by resident macrophages. Nanotechnology can also help in pulmonary therapies administered by intravenous and oral routes through targeting specific cell types and controlling bioavailability and release kinetics. In the hematology field, nanotechnology can counter multiple drug resistance in leukemia by blocking drug efflux from cancer cells, and provide effective delivery of siRNA into lymphocytes to block apoptosis in sepsis. Controlling the surface properties of materials on devices such as valves and stents promises improved biocompatibility by inhibition of thrombosis, the formation of blood clots, and regulating cell adhesion and activation. Nanoparticle-based thrombolytic agents have the potential to improve the effectiveness of clot removal. Treatment of both lung and blood diseases is also likely to benefit from nano-scaffold-based methods for controlling the differentiation and proliferation of stem and progenitor cells.
C1 NHLBI, Adv Technol & Surg Brannch, Div Cardiovasc Dis, Bethesda, MD 20892 USA.
RP Buxton, DB (reprint author), NHLBI, Adv Technol & Surg Brannch, Div Cardiovasc Dis, 6701 Rockledge Dr,Suite 8216, Bethesda, MD 20892 USA.
EM db225a@nih.gov
OI Buxton, Denis/0000-0003-3077-6435
FU Intramural NIH HHS [Z99 HL999999]
NR 49
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U1 1
U2 19
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1743-5889
J9 NANOMEDICINE-UK
JI Nanomedicine
PD APR
PY 2009
VL 4
IS 3
BP 331
EP 339
DI 10.2217/NNM.09.8
PG 9
WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
SC Biotechnology & Applied Microbiology; Science & Technology - Other
Topics
GA 432VK
UT WOS:000265162200013
PM 19331540
ER
PT J
AU Putney, JW
AF Putney, James W., Jr.
TI SOC: now also store-operated cyclase
SO NATURE CELL BIOLOGY
LA English
DT Editorial Material
ID ENDOPLASMIC-RETICULUM; SIGNALING ORGANELLE; CALCIUM INFLUX; CA2+ ENTRY;
STIM1; CRAC; CELL; ACTIVATION; CHANNELS; CAMP
AB depletion of Ca(2+) from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. we now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca(2+) store-regulated signalling.
C1 NIEHS, Lab Signal Transduct, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
RP Putney, JW (reprint author), NIEHS, Lab Signal Transduct, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA.
EM putney@niehs.nih.gov
NR 18
TC 5
Z9 5
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1465-7392
J9 NAT CELL BIOL
JI Nat. Cell Biol.
PD APR
PY 2009
VL 11
IS 4
BP 381
EP 382
PG 3
WC Cell Biology
SC Cell Biology
GA 434HD
UT WOS:000265264900008
PM 19337322
ER
PT J
AU Salles, FT
Merritt, RC
Manor, U
Dougherty, GW
Sousa, AD
Moore, JE
Yengo, CM
Dose, AC
Kachar, B
AF Salles, Felipe T.
Merritt, Raymond C., Jr.
Manor, Uri
Dougherty, Gerard W.
Sousa, Aurea D.
Moore, Judy E.
Yengo, Christopher M.
Dose, Andrea C.
Kachar, Bechara
TI Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to
the plus ends of actin filaments
SO NATURE CELL BIOLOGY
LA English
DT Article
ID HAIR-CELL STEREOCILIA; HEARING-LOSS; MOLECULAR TREADMILL; FILOPODIA
FORMATION; MOTOR; MUTATIONS; PROTEIN; LOCALIZATION; CYTOSKELETON;
ARCHITECTURE
AB Two proteins implicated in inherited deafness, myosin IIIa(1), a plus-end-directed motor(2), and espin(3-6), an actin-bundling protein containing the actin-monomer- binding motif WH2, have been shown to influence the length of mechanosensory stereocilia(7,8). Here we report that espin 1, an ankyrin repeat-containing isoform of espin(6), colocalizes with myosin IIIa at stereocilia tips and interacts with a unique conserved domain of myosin IIIa. We show that combined overexpression of these proteins causes greater elongation of stereocilia, compared with overexpression of either myosin IIIa alone or espin 1 alone. When these two proteins were co-expressed in the fibroblast-like COS-7 cell line they induced a tenfold elongation of filopodia. This extraordinary filopodia elongation results from the transport of espin 1 to the plus ends of F-actin by myosin IIIa and depends on espin 1 WH2 activity. This study provides the basis for understanding the role of myosin IIIa and espin 1 in regulating stereocilia length, and presents a physiological example where myosins can boost elongation of actin protrusions by transporting actin regulatory factors to the plus ends of actin filaments.
C1 [Salles, Felipe T.; Merritt, Raymond C., Jr.; Manor, Uri; Dougherty, Gerard W.; Sousa, Aurea D.; Kachar, Bechara] Natl Inst Deafness & Other Commun Disorders, Lab Cell Struct & Dynam, NIH, Bethesda, MD 20892 USA.
[Merritt, Raymond C., Jr.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Moore, Judy E.; Yengo, Christopher M.] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA.
[Dose, Andrea C.] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA.
RP Kachar, B (reprint author), Natl Inst Deafness & Other Commun Disorders, Lab Cell Struct & Dynam, NIH, Bethesda, MD 20892 USA.
EM kacharb@nidcd.nih.gov
RI Salles, Felipe/H-7544-2013;
OI Sousa, Aurea/0000-0002-9153-7414
FU NIDCD; DIR; NIH [EY003575, EY016419]
FX We thank Chi W. Pak for discussions and for the suggestion of mutations
in the WH2 motif, Mark Schneider and Saee da Latham for initial help
with experiments and for discussions related to this work, Martin Horak
for advice on cloning procedures, and Ronald Petralia for comments on
the manuscript. This work was supported by NIDCD, DIR, NIH and in part
by NIH grants to A.C.D. (no. EY003575) and to C.M.Y. (no. EY016419).
NR 32
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U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1465-7392
J9 NAT CELL BIOL
JI Nat. Cell Biol.
PD APR
PY 2009
VL 11
IS 4
BP 443
EP U180
DI 10.1038/ncb1851
PG 16
WC Cell Biology
SC Cell Biology
GA 434HD
UT WOS:000265264900014
PM 19287378
ER
PT J
AU Krishnamoorthy, L
Bess, JW
Preston, AB
Nagashima, K
Mahal, LK
AF Krishnamoorthy, Lakshmi
Bess, Julian W., Jr.
Preston, Alex B.
Nagashima, Kunio
Mahal, Lara K.
TI HIV-1 and microvesicles from T cells share a common glycome, arguing for
a common origin
SO NATURE CHEMICAL BIOLOGY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; IMMUNOAFFINITY DEPLETION; LECTIN
MICROARRAY; BINDING-PROTEINS; PLASMA-MEMBRANE; INFECTIVITY; GLYCANS;
MACROPHAGES; RECOGNITION; GALECTIN-1
AB HIV-1 is a master at deceiving the immune system and usurping host biosynthetic machinery. Although HIV-1 is coated with host-derived glycoproteins, only glycosylation of viral gp120 has been described. Here we use lectin microarray technology to analyze the glycome of intact HIV-1 virions. We show that the glycan coat of human T cell line-derived HIV-1 matches that of native immunomodulatory microvesicles. The carbohydrate composition of both virus and microvesicles is cell-line dependent, which suggests a mechanism to rapidly camouflage the virus within the host. In addition, binding of both virus and microvesicles to antiviral lectins is enriched over the host cell, raising concern about targeting these glycans for therapeutics. This work also sheds light on the binding of HIV-1 to galectin-1, an important human immune lectin. Overall, our work strongly supports the theory that HIV-1 co-opts the exocytic pathway of microvesicles, thus potentially explaining why eliciting a protective antiviral immune response is difficult.
C1 [Krishnamoorthy, Lakshmi; Preston, Alex B.; Mahal, Lara K.] Univ Texas Austin, Dept Chem & Biochem, Ctr Syst & Synthet Biol, Austin, TX 78712 USA.
[Krishnamoorthy, Lakshmi; Preston, Alex B.; Mahal, Lara K.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA.
[Bess, Julian W., Jr.] NCI, AIDS Vaccine Program, Frederick, MD USA.
[Nagashima, Kunio] NCI, SAIC Frederick Inc, Image Anal Lab, Frederick, MD USA.
RP Mahal, LK (reprint author), Univ Texas Austin, Dept Chem & Biochem, Ctr Syst & Synthet Biol, Austin, TX 78712 USA.
EM lmahal@cm.utexas.edu
OI Krishnamoorthy, Lakshmi/0000-0002-4083-526X
FU Consortium for Functional Glycomics [GM62116]; US National Science
Foundation; National Cancer Institute, National Institutes of Health
[N01-CO-12400]
FX We thank B. Bohn, J. Miller and B. Imming (AIDS Vaccine Program,
NCI-Frederick) for help with virus and microvesicle purification; E.
Chertova and D. Roser (AIDS Vaccine Program, NCI-Frederick) for
biochemical analysis of the samples; D. Graham (University of Texas,
Austin) for generous use of his ultracentrifuge; L. Baum (UCLA Medical
School) for the generous gift of galectin-1; B. O'Keefe (NCI-Frederick)
for the generous gift of cyanovirin, scytovirin and griffithsin; E.
Thoyakulathu for help in the lectin analysis; University of Texas at
Austin Microarray Core Facility; and J. Lifson (NCI- Frederick) for
insightful reading of the manuscript. We thank Q. Sattentau (University
of Oxford) for the Jurkat-Tat-CCR5 cells. In addition, we wish to
acknowledge the Consortium for Functional Glycomics (grant number
GM62116) for publicly available glycan array data from their database
used in this work. Funding was provided by the Arnold and Mabel Beckman
Foundation (L. K. M.) and the US National Science Foundation (CAREER
CHE-0644530, L. K. M.), and by federal funds from the National Cancer
Institute, National Institutes of Health, under contract N01-CO-12400
(J. W. B.). The content of this publication does not necessarily reflect
the views or policies of the Department of Health and Human Services,
nor does mention of trade names, commercial products, or organizations
imply endorsement by the US Government.
NR 43
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U1 1
U2 11
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1552-4450
J9 NAT CHEM BIOL
JI Nat. Chem. Biol.
PD APR
PY 2009
VL 5
IS 4
BP 244
EP 250
DI 10.1038/nchembio.151
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 422KH
UT WOS:000264426100013
PM 19234452
ER
PT J
AU Newton-Cheh, C
Eijgelsheim, M
Rice, KM
de Bakker, PIW
Yin, XY
Estrada, K
Bis, JC
Marciante, K
Rivadeneira, F
Noseworthy, PA
Sotoodehnia, N
Smith, NL
Rotter, JI
Kors, JA
Witteman, JCM
Hofman, A
Heckbert, SR
O'Donnell, CJ
Uitterlinden, AG
Psaty, BM
Lumley, T
Larson, MG
Stricker, BHC
AF Newton-Cheh, Christopher
Eijgelsheim, Mark
Rice, Kenneth M.
de Bakker, Paul I. W.
Yin, Xiaoyan
Estrada, Karol
Bis, Joshua C.
Marciante, Kristin
Rivadeneira, Fernando
Noseworthy, Peter A.
Sotoodehnia, Nona
Smith, Nicholas L.
Rotter, Jerome I.
Kors, Jan A.
Witteman, Jacqueline C. M.
Hofman, Albert
Heckbert, Susan R.
O'Donnell, Christopher J.
Uitterlinden, Andre G.
Psaty, Bruce M.
Lumley, Thomas
Larson, Martin G.
Stricker, Bruno H. Ch
TI Common variants at ten loci influence QT interval duration in the QTGEN
Study
SO NATURE GENETICS
LA English
DT Article
ID SUDDEN CARDIAC DEATH; GENOME-WIDE ASSOCIATION; NOS1 REGULATOR NOS1AP;
PHOSPHOLAMBAN GENE; HEART; REPOLARIZATION; FRAMINGHAM; SCN5A; KCNH2;
POLYMORPHISM
AB QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a heritable risk factor for sudden cardiac death and drug-induced arrhythmias. We conducted a meta-analysis of three genome-wide association studies in 13,685 individuals of European ancestry from the Framingham Heart Study, the Rotterdam Study and the Cardiovascular Health Study, as part of the QTGEN consortium. We observed associations at P < 5 x 10(-8) with variants in NOS1AP, KCNQ1, KCNE1, KCNH2 and SCN5A, known to be involved in myocardial repolarization and mendelian long-QT syndromes. Associations were found at five newly identified loci, including 16q21 near NDRG4 and GINS3, 6q22 near PLN, 1p36 near RNF207, 16p13 near LITAF and 17q12 near LIG3 and RFFL. Collectively, the 14 independent variants at these 10 loci explain 5.4-6.5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias.
C1 [Newton-Cheh, Christopher; Noseworthy, Peter A.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Ctr Human Genet Res, Boston, MA 02114 USA.
[Newton-Cheh, Christopher; de Bakker, Paul I. W.] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02138 USA.
[Newton-Cheh, Christopher; de Bakker, Paul I. W.] MIT, Cambridge, MA 02139 USA.
[Newton-Cheh, Christopher; Yin, Xiaoyan; O'Donnell, Christopher J.; Larson, Martin G.] NHLBI, Framingham Heart Study, Framingham, MA USA.
[Eijgelsheim, Mark; Rivadeneira, Fernando; Witteman, Jacqueline C. M.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H. Ch] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
[Rice, Kenneth M.; Lumley, Thomas] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[de Bakker, Paul I. W.] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.
[Yin, Xiaoyan; Larson, Martin G.] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA.
[Estrada, Karol; Rivadeneira, Fernando; Uitterlinden, Andre G.; Stricker, Bruno H. Ch] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
[Bis, Joshua C.; Marciante, Kristin; Sotoodehnia, Nona; Smith, Nicholas L.; Heckbert, Susan R.; Psaty, Bruce M.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.
[Sotoodehnia, Nona] Univ Washington, Dept Med, Sch Med, Div Cardiol, Seattle, WA 98195 USA.
[Smith, Nicholas L.; Heckbert, Susan R.; Psaty, Bruce M.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
[Smith, Nicholas L.] Vet Adm Off Res & Dev, Seattle Epidemiol Res Ctr, Seattle, WA USA.
[Rotter, Jerome I.] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA.
[Kors, Jan A.; Stricker, Bruno H. Ch] Erasmus MC, Dept Med Informat, Rotterdam, Netherlands.
[Witteman, Jacqueline C. M.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H. Ch] Netherlands Genom Initiat Sponsored Netherlands C, NL-3000 CA Rotterdam, Netherlands.
[Heckbert, Susan R.; Psaty, Bruce M.] Grp Hlth, Ctr Hlth Studies, Seattle, WA USA.
[O'Donnell, Christopher J.] NHLBI, Bethesda, MD 20892 USA.
[O'Donnell, Christopher J.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
[Psaty, Bruce M.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.
[Stricker, Bruno H. Ch] Inspectorate Hlth Care, The Hague, Netherlands.
RP Newton-Cheh, C (reprint author), Massachusetts Gen Hosp, Cardiovasc Res Ctr, Ctr Human Genet Res, Boston, MA 02114 USA.
EM b.stricker@erasmusmc.nl
RI Rice, Kenneth/A-4150-2013; de Bakker, Paul/B-8730-2009; Rivadeneira,
Fernando/O-5385-2015;
OI Rice, Kenneth/0000-0001-5779-4495; de Bakker, Paul/0000-0001-7735-7858;
Rivadeneira, Fernando/0000-0001-9435-9441; Larson,
Martin/0000-0002-9631-1254
FU Framingham Heart Study of the National Heart Lung and Blood Institute of
the National Institutes of Health; Boston University School of Medicine
[N01-HC-25195]; Affymetrix [N02-HL-6-4278]; Doris Duke Charitable
Foundation; Burroughs Wellcome Fund; Department of Medicine at Boston
University School of Medicine; Boston Medical Center; Pfizer; Erasmus
Medical Center and Erasmus University, Rotterdam; Netherlands
Organization for the Health Research and Development (ZonMw); Research
Institute for Diseases in the Elderly (RIDE); Ministry of Education,
Culture and Science; Ministry for Health, Welfare and Sports, the
European Commission (DG XII); Municipality of Rotterdam; Netherlands
Organisation of Scientific Research NWO Investments [175.010.2005.011,
911-03-012]; Research Institute for Diseases [014-93-015, RIDE2];
Netherlands Genomics Initiative (NGI)/Netherlands Organisation for
Scientific Research (NWO) [050-060-810]; CHS [N01-HC85079, N01-HC-85086,
N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133];
National Institute of Neurological Disorders and Stroke [U01 HL080295,
R01 HL087652]; National Center for Research Resources [M01RR00069];
National Institute of Diabetes and Digestive and Kidney Diseases
[DK063491]; CHARGE (Cohorts for Heart and Aging Research in Genome
Epidemiology); US National Institutes of Health [K23-HL-080025]; Doris
Duke Charitable Foundation Clinical Scientist Development Award;
Burroughs Wellcome Fund Career Award; Netherlands Heart Foundation
[2007B221]
FX The Framingham Heart Study work was conducted in part using data and
resources from the Framingham Heart Study of the National Heart Lung and
Blood Institute of the National Institutes of Health and Boston
University School of Medicine (contract #N01-HC-25195), its contract
with Affymetrix for genotyping services (contract #N02-HL-6-4278), and
the Doris Duke Charitable Foundation (C.N.-C.) and Burroughs Wellcome
Fund (C.N.-C.). The Framingham analyses reflect intellectual input and
resource development from the Framingham Heart Study investigators
participating in the SNP Health Association Resource (SHARe) project. A
portion of this research utilized the Linux Cluster for Genetic Analysis
(LinGA-II) funded by the Robert Dawson Evans Endowment of the Department
of Medicine at Boston University School of Medicine and Boston Medical
Center. The measurement of ECG intervals in Framingham Heart Study
generation 1 and 2 samples was done by eResearch Technology and
supported by an unrestricted grant from Pfizer. The measurement of ECG
intervals in the Framingham Heart Study generation 3 sample was
completed by A. Hirji and S. Kovvali using AMPS software provided
through an unrestricted academic license by Analyzing Medical Parameters
for Solutions (A.M.P.S., LLC). The Rotterdam Study is funded by Erasmus
Medical Center and Erasmus University, Rotterdam, Netherlands
Organization for the Health Research and Development (ZonMw), the
Research Institute for Diseases in the Elderly (RIDE), the Ministry of
Education, Culture and Science, the Ministry for Health, Welfare and
Sports, the European Commission (DG XII), and the Municipality of
Rotterdam. The generation and management of GWAS genotype data for the
Rotterdam Study is supported by the Netherlands Organisation of
Scientific Research NWO Investments (#175.010.2005.011, 911-03-012).
This study is funded by the Research Institute for Diseases in the
Elderly (014-93-015; RIDE2), and the Netherlands Genomics Initiative
(NGI)/Netherlands Organisation for Scientific Research (NWO) project
#050-060-810. The CHS research reported in this article was supported by
contract numbers N01-HC85079 through N01-HC-85086, N01-HC-35129, N01
HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant numbers U01
HL080295 and R01 HL087652 from the National Heart, Lung, and Blood
Institute, with additional contribution from the National Institute of
Neurological Disorders and Stroke. DNA handling and genotyping was
supported in part by National Center for Research Resources grant
M01RR00069 to the Cedars-Sinai General Clinical Research Center
Genotyping core and National Institute of Diabetes and Digestive and
Kidney Diseases grant DK063491 to the Southern California Diabetes
Endocrinology Research Center. A full list of principal CHS
investigators and institutions can be found at
http://www.chs-nhlbi.org/pi.htm. The authors acknowledge the essential
role of the CHARGE (Cohorts for Heart and Aging Research in Genome
Epidemiology) Consortium in development and support of this manuscript.
CHARGE members include the Netherland's Rotterdam Study, the NHLBI's
Atherosclerosis Risk in Communities (ARIC) Study, Cardiovascular Health
Study (CHS) and Framingham Heart Study (FHS), and the NIA's Iceland Age,
Gene/Environment Susceptibility (AGES) Study. C. N.-C. is supported by
US National Institutes of Health grant K23-HL-080025, a Doris Duke
Charitable Foundation Clinical Scientist Development Award, and a
Burroughs Wellcome Fund Career Award for Medical Scientists. M. E.; is
funded by the Netherlands Heart Foundation (#2007221). J.I.R. is
supported by the Cedars-Sinai Board of Governors' Chair in Medical
Genetics. The authors wish to thank the following people: G. Crawford
and C. Guiducci (Broad Institute of Harvard and Massachusetts Institute
of Technology) who completed the Sequenom-based technical validation
genotyping of the Framingham Heart Study samples; P. Arp and M. Jhamai
(Erasmus Medical Center) for Illumina array genotyping and Taqman-based
technical validation genotyping of the Rotterdam Study samples; and Dr.
M. Moorhouse, M. Verkerk and S. Bervoets (Erasmus Medical Center) for
database management in the Rotterdam Study; and the study participants,
the staff from the Rotterdam Study and the participating general
practitioners and pharmacists. The QTGEN consortium would like to thank
the QTSCD consortium for the opportunity to exchange top results
pre-publication.
NR 45
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U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD APR
PY 2009
VL 41
IS 4
BP 399
EP 406
DI 10.1038/ng.364
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 425TC
UT WOS:000264659000012
PM 19305408
ER
PT J
AU Pfeufer, A
Sanna, S
Arking, DE
Muller, M
Gateva, V
Fuchsberger, C
Ehret, GB
Orru, M
Pattaro, C
Kottgen, A
Perz, S
Usala, G
Barbalic, M
Li, M
Putz, B
Scuteri, A
Prineas, RJ
Sinner, MF
Gieger, C
Najjar, SS
Kao, WHL
Muhleisen, TW
Dei, M
Happle, C
Mohlenkamp, S
Crisponi, L
Erbel, R
Jockel, KH
Naitza, S
Steinbeck, G
Marroni, F
Hicks, AA
Lakatta, E
Muller-Myhsok, B
Pramstaller, PP
Wichmann, HE
Schlessinger, D
Boerwinkle, E
Meitinger, T
Uda, M
Coresh, J
Kaab, S
Abecasis, GR
Chakravarti, A
AF Pfeufer, Arne
Sanna, Serena
Arking, Dan E.
Mueller, Martina
Gateva, Vesela
Fuchsberger, Christian
Ehret, Georg B.
Orru, Marco
Pattaro, Cristian
Koettgen, Anna
Perz, Siegfried
Usala, Gianluca
Barbalic, Maja
Li, Man
Puetz, Benno
Scuteri, Angelo
Prineas, Ronald J.
Sinner, Moritz F.
Gieger, Christian
Najjar, Samer S.
Kao, W. H. Linda
Muehleisen, Thomas W.
Dei, Mariano
Happle, Christine
Moehlenkamp, Stefan
Crisponi, Laura
Erbel, Raimund
Joeckel, Karl-Heinz
Naitza, Silvia
Steinbeck, Gerhard
Marroni, Fabio
Hicks, Andrew A.
Lakatta, Edward
Mueller-Myhsok, Bertram
Pramstaller, Peter P.
Wichmann, H-Erich
Schlessinger, David
Boerwinkle, Eric
Meitinger, Thomas
Uda, Manuela
Coresh, Josef
Kaeaeb, Stefan
Abecasis, Goncalo R.
Chakravarti, Aravinda
TI Common variants at ten loci modulate the QT interval duration in the
QTSCD Study
SO NATURE GENETICS
LA English
DT Article
ID NOS1 REGULATOR NOS1AP; SUDDEN CARDIAC DEATH; HEART-FAILURE; HEALTHY
POPULATION; GENETIC VARIANT; DISEASE; REPOLARIZATION; RISK; ASSOCIATION;
MUTATION
AB The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death ( SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8). Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD.
C1 [Arking, Dan E.; Ehret, Georg B.; Chakravarti, Aravinda] Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21218 USA.
[Pfeufer, Arne; Happle, Christine; Meitinger, Thomas] Helmholtz Ctr Munich, Inst Human Genet, Munich, Germany.
[Pfeufer, Arne; Happle, Christine; Meitinger, Thomas] Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, D-80804 Munich, Germany.
[Sanna, Serena; Orru, Marco; Usala, Gianluca; Crisponi, Laura; Naitza, Silvia; Uda, Manuela] CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy.
[Mueller, Martina; Gieger, Christian; Wichmann, H-Erich] Helmholtz Ctr Munich, Inst Epidemiol, Munich, Germany.
[Mueller, Martina; Wichmann, H-Erich] Univ Munich, Inst Informat Biometry & Epidemiol, Munich, Germany.
[Mueller, Martina; Sinner, Moritz F.; Kaeaeb, Stefan] Univ Munich, Klinikum Grosshadern, Dept Med 1, D-80804 Munich, Germany.
[Gateva, Vesela; Abecasis, Goncalo R.] Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
[Fuchsberger, Christian; Pattaro, Cristian; Marroni, Fabio; Hicks, Andrew A.; Pramstaller, Peter P.] EURAC European Acad, Inst Med Genet, Bolzano, Italy.
[Koettgen, Anna; Li, Man; Kao, W. H. Linda; Coresh, Josef] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA.
[Perz, Siegfried] Helmholtz Ctr Munich, Inst Med Informat, Munich, Germany.
[Barbalic, Maja; Boerwinkle, Eric] Univ Texas Hlth Sci Ctr, Genet Ctr, Houston, TX USA.
[Puetz, Benno; Mueller-Myhsok, Bertram] Max Planck Inst Psychiat, D-80804 Munich, Germany.
[Scuteri, Angelo] Ist Ricovero & Cura Anziani, Unita Operat Geriatria, Rome, Italy.
[Prineas, Ronald J.] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA.
[Najjar, Samer S.; Lakatta, Edward] NIA, Cardiovasc Sci Lab, Gerontol Res Ctr, Baltimore, MD 21224 USA.
[Muehleisen, Thomas W.] Univ Bonn, Life & Brain Ctr, Dept Genom, D-5300 Bonn, Germany.
[Muehleisen, Thomas W.] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany.
[Moehlenkamp, Stefan; Erbel, Raimund] Univ Duisburg Essen, Univ Hosp Essen, W German Heart Ctr, Clin Cardiol, Duisburg, Germany.
[Joeckel, Karl-Heinz] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Duisburg, Germany.
[Pramstaller, Peter P.] Gen Cent Hosp, Dept Neurol, Bolzano, Italy.
[Pramstaller, Peter P.] Med Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany.
[Schlessinger, David] NIA, Genet Lab, Baltimore, MD 21224 USA.
[Coresh, Josef; Chakravarti, Aravinda] Johns Hopkins Univ, Dept Med, Baltimore, MD USA.
RP Chakravarti, A (reprint author), Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21218 USA.
EM arne.pfeufer@helmholtz-muenchen.de; aravinda@jhmi.edu
RI Pramstaller, Peter/C-2357-2008; Abecasis, Goncalo/B-7840-2010;
Fuchsberger, Christian/C-9646-2010; EHRET, Georg/A-9532-2009; Kottgen,
Anna/D-2920-2012; Kaab, Stefan/H-3915-2012; Muller-Myhsok,
Bertram/A-3289-2013; Pfeufer, Arne/B-6634-2013; Meitinger,
Thomas/O-1318-2015; Putz, Benno/P-2630-2016; Naitza, Silvia/D-5620-2017;
Hicks, Andrew/E-9518-2017;
OI EHRET, Georg/0000-0002-5730-0675; Putz, Benno/0000-0002-2208-209X;
Hicks, Andrew/0000-0001-6320-0411; Marroni, Fabio/0000-0002-1556-5907;
Fuchsberger, Christian/0000-0002-5918-8947; sanna,
serena/0000-0002-3768-1749; Abecasis, Goncalo/0000-0003-1509-1825;
Gieger, Christian/0000-0001-6986-9554
FU National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016,
N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022,
R01HL087641, R01HL59367, R01HL086694]; National Human Genome Research
Institute [U01HG004402]; National Institutes of Health
[HHSN268200625226C, UL1RR025005]; NHLBI [HL86694, HL054512]; Donald W.
Reynolds Cardiovascular Clinical Research Center at Johns Hopkins
University; German Research Foundation Fellowship; German Federal
Ministry of Education and Research (BMBF); German National Genome
Research Network (NGFN); German National Competence network on atrial
fibrillation (AFNET); Bioinformatics for the Functional Analysis of
Mammalian Genomes [NGFN 01GS0499, 01GS0838, AF-Net01GI0204/N]; Fondation
Leducq; State of Bavaria; National Institute on Aging [NO1-AG-1-2109];
National Institute on Aging to the University of Michigan
[263-MA-410953]; National Human Genome Research Institute; National
Heart, Lung, and Blood Institute; Ministry of Health of the Autonomous
Province of Bolzano; South Tyrolean Sparkasse Foundation; Heinz Nixdorf
Foundation; [NGFN 01GR0803]; [01EZ0874]; [NGFN 01GI0204]; [NGFN
01GR0103]
FX We gratefully acknowledge all participants in the community-based
studies of ARIC, KORA, SardiNIA, GenNOVA and Heinz Nixdorf Recall Study,
and all the members of our laboratories for helpful discussion of this
study. We thank G. Fischer for help with genotype imputation and data
management for the KORA samples, Y. Li for her help on statistical
analysis, K. Tarasov for in silico promotor analysis, A. Cao for his
valuable advice and support in the SardiNIA project and all ARIC, KORA,
SardiNIA, GenNOVA and Heinz Nixdorf Recall Study investigators for study
design and continued operation. We also thank C. Egger and Y. D'Elia for
the valuable support in data management and data administration; S.
Melville and M. Facheris for the important work of drug classification
in the GenNOVA project; and the primary care practitioners R. Stocker,
S. Waldner, T. Pizzecco, J. Plangger, U. Marcadent and the personnel of
the Hospital of Silandro (Department of Laboratory Medicine) for their
participation and collaboration in the GenNOVA project. ARIC is carried
out as a collaborative study supported by National Heart, Lung, and
Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018,
N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641,
R01HL59367 and R01HL086694; National Human Genome Research Institute
contract U01HG004402; and National Institutes of Health contract
HHSN268200625226C. Infrastructure was partly supported by Grant Number
UL1RR025005, a component of the National Institutes of Health and NIH
Roadmap for Medical Research. In addition, we acknowledge support from
NHLBI grants HL86694 and HL054512, and the Donald W. Reynolds
Cardiovascular Clinical Research Center at Johns Hopkins University for
genotyping and data analysis relevant to this study. A. K. is supported
by a German Research Foundation Fellowship.; The KORA study was funded
by grants by the German Federal Ministry of Education and Research
(BMBF) in the context of the German National Genome Research Network
(NGFN), the German National Competence network on atrial fibrillation
(AFNET) and the Bioinformatics for the Functional Analysis of Mammalian
Genomes program (BFAM) by grants to S. K. (NGFN 01GS0499, 01GS0838 and
AF-Net01GI0204/N), A. P. (NGFN 01GR0803, 01EZ0874), H.-E. W. (NGFN
01GI0204) and to T. M. (NGFN 01GR0103). S. K. is also supported by a
grant from the Fondation Leducq. The KORA platform is funded by the BMBF
and by the State of Bavaria.; The SardiNIA team was supported by
Contract NO1-AG-1-2109 from the National Institute on Aging and in part
by the Intramural Research Program of the US National Institute on
Aging, NIH. The efforts of G. R. A. were supported in part by contract
263-MA-410953 from the National Institute on Aging to the University of
Michigan and by research grants from the National Human Genome Research
Institute and the National Heart, Lung, and Blood Institute (to G. R.
A.). The GenNOVA study was supported by the Ministry of Health of the
Autonomous Province of Bolzano and the South Tyrolean Sparkasse
Foundation. The Heinz Nixdorf Recall Study was funded by a grant of the
Heinz Nixdorf Foundation (Chairman: G. Schmidt).
NR 41
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U1 2
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD APR
PY 2009
VL 41
IS 4
BP 407
EP 414
DI 10.1038/ng.362
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 425TC
UT WOS:000264659000013
PM 19305409
ER
PT J
AU Fraser, IDC
Germain, RN
AF Fraser, Iain D. C.
Germain, Ronald N.
TI Navigating the network: signaling cross-talk in hematopoietic cells
SO NATURE IMMUNOLOGY
LA English
DT Review
ID PROTEIN INTERACTION NETWORK; RNA-INTERFERENCE; SYSTEMS BIOLOGY;
MULTIPLEXED ANALYSIS; FLUORESCENT PROTEIN; GENE-EXPRESSION; IN-VIVO;
TRANSDUCTION; TYROSINE; KINASE
AB Recent studies in hematopoietic cells have led to a growing appreciation of the diverse modes of molecular and functional crosstalk between canonical signaling pathways. However, these intersections represent only the tip of the iceberg. Emerging global analytical methods are providing an even richer and more complete picture of the many components that measurably interact in a network manner to produce cellular responses. Here we highlight the pieces in this Focus, emphasize the limitations of the present canonical pathway paradigm, and discuss the value of a systems biology approach using more global, quantitative experimental design and data analysis strategies. Lastly, we urge caution about overly facile interpretation of genome-and proteome-level studies.
C1 [Fraser, Iain D. C.] NIAID, Mol & Cell Biol Grp, NIH, Bethesda, MD 20892 USA.
[Germain, Ronald N.] NIAID, Immunol Grp, Program Syst Immunol & Infect Dis Modeling, NIH, Bethesda, MD 20892 USA.
[Germain, Ronald N.] NIAID, Lymphocyte Biol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA.
RP Fraser, IDC (reprint author), NIAID, Mol & Cell Biol Grp, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
FU US National Institutes of Health, National Institute of Allergy and
Infectious Diseases
FX Supported by the Intramural Research Program of the US National
Institutes of Health, National Institute of Allergy and Infectious
Diseases.
NR 57
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U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1529-2908
J9 NAT IMMUNOL
JI Nat. Immunol.
PD APR
PY 2009
VL 10
IS 4
BP 327
EP 331
DI 10.1038/ni.1711
PG 5
WC Immunology
SC Immunology
GA 422KE
UT WOS:000264425800002
PM 19295628
ER
PT J
AU Ghoreschi, K
Laurence, A
O'Shea, JJ
AF Ghoreschi, Kamran
Laurence, Arian
O'Shea, John J.
TI Selectivity and therapeutic inhibition of kinases: to be or not to be?
SO NATURE IMMUNOLOGY
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE;
POLYCYTHEMIA-VERA; RHEUMATOID-ARTHRITIS; MYELOPROLIFERATIVE DISORDERS;
DOUBLE-BLIND; HUMAN GENOME; MUTATION; JAK2
AB Protein kinases, which serve critical functions in signaling pathways in all cells, are popular therapeutic targets. At present, eight kinase inhibitors have been approved in the United States, each of which shows nanomolar potency. Although the initial goal was to generate inhibitors with a high degree of selectivity, recent experience has revealed that many of these approved compounds target more than one kinase. Surprisingly, this promiscuity is less problematic than one would have imagined; indeed, it opens new therapeutic opportunities. In this Perspective, we discuss the present status of Janus kinase inhibitors-a new class of immunosuppressive drugs-and the advantages and disadvantages of selectively inhibiting this class of kinase.
C1 [Ghoreschi, Kamran; Laurence, Arian; O'Shea, John J.] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
RP Ghoreschi, K (reprint author), NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
EM ghoreschik@mail.nih.gov; osheajo@mail.nih.gov
RI Laurence, Arian/A-8770-2009
OI Laurence, Arian/0000-0003-0942-8292
FU Intramural NIH HHS [Z99 AR999999]
NR 44
TC 126
Z9 128
U1 1
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1529-2908
J9 NAT IMMUNOL
JI Nat. Immunol.
PD APR
PY 2009
VL 10
IS 4
BP 356
EP 360
DI 10.1038/ni.1701
PG 5
WC Immunology
SC Immunology
GA 422KE
UT WOS:000264425800006
PM 19295632
ER
PT J
AU Nakano, H
Lin, KL
Yanagita, M
Charbonneau, C
Cook, DN
Kakiuchi, T
Gunn, MD
AF Nakano, Hideki
Lin, Kaifeng Lisa
Yanagita, Manabu
Charbonneau, Chantal
Cook, Donald N.
Kakiuchi, Terutaka
Gunn, Michael D.
TI Blood-derived inflammatory dendritic cells in lymph nodes stimulate
acute T helper type 1 immune responses
SO NATURE IMMUNOLOGY
LA English
DT Article
ID MICE LACKING EXPRESSION; STEADY-STATE; IN-VIVO; MONOCYTE RECRUITMENT;
AIRWAY INFLAMMATION; ADAPTIVE IMMUNITY; CHEMOKINES CCL19; ORGAN
CHEMOKINE; KNOCKOUT MICE; ANTIGEN
AB T helper type 1 (T(H)1)- polarized immune responses, which confer protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues. Here we found after viral infection or immunization, inflammatory monocytes were recruited into lymph nodes directly from the blood to become CD11c(+) CD11b(hi)Gr-1(+) inflammatory DCs, which produced abundant interleukin 12p70 and potently stimulated T(H)1 responses. This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7. Thus, the accumulation of inflammatory DCs and T(H)1 responses were much lower in Ccr2(-/-) mice, were preserved in Ccl2(-/-) mice and were relatively higher in CCL19-CCL21-Ser-deficient plt mutant mice, in which all other lymph node DC types were fewer in number. We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses.
C1 [Nakano, Hideki; Yanagita, Manabu; Charbonneau, Chantal; Gunn, Michael D.] Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.
[Nakano, Hideki; Lin, Kaifeng Lisa; Gunn, Michael D.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA.
[Nakano, Hideki; Cook, Donald N.] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Res Triangle Pk, NC USA.
[Kakiuchi, Terutaka] Toho Univ, Sch Med, Dept Immunol, Tokyo, Japan.
RP Gunn, MD (reprint author), Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.
EM michael.gunn@duke.edu
OI Gunn, Michael/0000-0003-4602-0667
FU National Institutes of Health [AI047262, HL085473]; Japanese Ministry of
Science and Technology [1579054, 14021121]; Duke Human Vaccine
Institute; Japan Health Sciences Foundation [KH51052]; Japan Society for
the Promotion of Science [10670606, 12670621]; Japan Society for the
Promotion of Science for Young Scientists; National Institute of
Environmental Health Sciences
FX We thank K. Nakano for technical assistance, and J. Whitesides, P.
McDermott and L. Olive for cell sorting. Supported by the National
Institutes of Health (AI047262 and HL085473 to M. D. G.), the Japanese
Ministry of Science and Technology (1579054 to H. N., and 14021121 to T.
K.), the Duke Human Vaccine Institute (H. N.), the Japan Health Sciences
Foundation (KH51052 to T. K.), the Japan Society for the Promotion of
Science (10670606, 12670621 to T. K.), the Japan Society for the
Promotion of Science for Young Scientists (M. Y.) and the intramural
branch of the National Institute of Environmental Health Sciences of the
National Institutes of Health.
NR 44
TC 177
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U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1529-2908
J9 NAT IMMUNOL
JI Nat. Immunol.
PD APR
PY 2009
VL 10
IS 4
BP 394
EP 402
DI 10.1038/ni.1707
PG 9
WC Immunology
SC Immunology
GA 422KE
UT WOS:000264425800013
PM 19252492
ER
PT J
AU Robey, PG
AF Robey, Pamela Gehron
TI Neuropeptide beckons cells that heal
SO NATURE MEDICINE
LA English
DT Editorial Material
ID STEM-CELLS; CONNECTIVE-TISSUE; STROMAL CELLS; HUMANS; BLOOD
AB Experiments in rodents identify a factor that causes the release of multipotent cells into the circulation after injury. These cells contribute to tissue repair (pages 425-435).
C1 Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, US Natl Inst Hlth, Dept Hlth & Human Serv, Bethesda, MD USA.
RP Robey, PG (reprint author), Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, US Natl Inst Hlth, Dept Hlth & Human Serv, Bethesda, MD USA.
EM probey@dir.nidcr.nih.gov
RI Robey, Pamela/H-1429-2011
OI Robey, Pamela/0000-0002-5316-5576
FU Intramural NIH HHS [Z01 DE000380-24]
NR 11
TC 1
Z9 1
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
J9 NAT MED
JI Nat. Med.
PD APR
PY 2009
VL 15
IS 4
BP 367
EP 369
DI 10.1038/nm0409-367
PG 4
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 429RG
UT WOS:000264937200016
PM 19350006
ER
PT J
AU Hammad, H
Chieppa, M
Perros, F
Willart, MA
Germain, RN
Lambrecht, BN
AF Hammad, Hamida
Chieppa, Marcello
Perros, Frederic
Willart, Monique A.
Germain, Ronald N.
Lambrecht, Bart N.
TI House dust mite allergen induces asthma via Toll-like receptor 4
triggering of airway structural cells
SO NATURE MEDICINE
LA English
DT Article
ID THYMIC STROMAL LYMPHOPOIETIN; DENDRITIC CELLS; EPITHELIAL-CELLS;
ALVEOLAR MACROPHAGES; INHALED ENDOTOXIN; TYPE-2 RESPONSES; TH2
RESPONSES; LYMPH-NODES; T-CELLS; INFLAMMATION
AB Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense against inhaled substances such as house dust mite (HDM) allergen and endotoxin (lipopolysaccharide, LPS). We hypothesized that these cells need to communicate with each other to cause allergic disease. We show in irradiated chimeric mice that Toll-like receptor 4 (TLR4) expression on radioresistant lung structural cells, but not on DCs, is necessary and sufficient for DC activation in the lung and for priming of effector T helper responses to HDM. TLR4 triggering on structural cells caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage colony-stimulating factor, interleukin-25 and interleukin-33. The absence of TLR4 on structural cells, but not on hematopoietic cells, abolished HDM-driven allergic airway inflammation. Finally, inhalation of a TLR4 antagonist to target exposed epithelial cells suppressed the salient features of asthma, including bronchial hyperreactivity. Our data identify an innate immune function of airway epithelial cells that drives allergic inflammation via activation of mucosal DCs.
C1 [Hammad, Hamida; Perros, Frederic; Willart, Monique A.; Lambrecht, Bart N.] Univ Ghent, Dept Resp Med, Lab Immunoregulat & Mucosal Immunol, B-9000 Ghent, Belgium.
[Chieppa, Marcello; Germain, Ronald N.] NIAID, Immunol Lab, Sect Lymphocyte Biol, US Natl Inst Hlth, Bethesda, MD 20892 USA.
[Lambrecht, Bart N.] Erasmus Univ, Med Ctr, Dept Pulm Med, Rotterdam, Netherlands.
RP Lambrecht, BN (reprint author), Univ Ghent, Dept Resp Med, Lab Immunoregulat & Mucosal Immunol, B-9000 Ghent, Belgium.
EM bart.lambrecht@ugent.be
RI Chieppa, Marcello/K-4846-2012; Hammad, Hamida/J-9391-2015; Lambrecht,
Bart/K-2484-2014
OI Hammad, Hamida/0000-0003-3762-8603; Lambrecht, Bart/0000-0003-4376-6834
FU Intramural NIH HHS [ZIA AI000545-21]
NR 45
TC 514
Z9 531
U1 4
U2 41
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
J9 NAT MED
JI Nat. Med.
PD APR
PY 2009
VL 15
IS 4
BP 410
EP 416
DI 10.1038/nm.1946
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 429RG
UT WOS:000264937200028
PM 19330007
ER
PT J
AU Hager, G
AF Hager, Gordon
TI Footprints by deep sequencing
SO NATURE METHODS
LA English
DT Editorial Material
ID CHROMATIN; GENOME; ENHANCER
C1 NCI, Lab Receptor Biol & Gene Express, Natl Inst Hlth, Bethesda, MD 20892 USA.
RP Hager, G (reprint author), NCI, Lab Receptor Biol & Gene Express, Natl Inst Hlth, Bethesda, MD 20892 USA.
EM hagerg@exchange.nih.gov
NR 7
TC 5
Z9 6
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1548-7091
J9 NAT METHODS
JI Nat. Methods
PD APR
PY 2009
VL 6
IS 4
BP 254
EP 256
DI 10.1038/nmeth0409-254
PG 3
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 426WK
UT WOS:000264738800011
PM 19333240
ER
PT J
AU Gerstner, ER
Duda, DG
di Tomaso, E
Ryg, PA
Loeffler, JS
Sorensen, AG
Ivy, P
Jain, RK
Batchelor, TT
AF Gerstner, Elizabeth R.
Duda, Dan G.
di Tomaso, Emmanuelle
Ryg, Peter A.
Loeffler, Jay S.
Sorensen, A. Gregory
Ivy, Percy
Jain, Rakesh K.
Batchelor, Tracy T.
TI VEGF inhibitors in the treatment of cerebral edema in patients with
brain cancer
SO NATURE REVIEWS CLINICAL ONCOLOGY
LA English
DT Review
ID ENDOTHELIAL-GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; APPARENT
DIFFUSION-COEFFICIENT; TYROSINE KINASE INHIBITOR; MAGNETIC-RESONANCE;
TUMOR ANGIOGENESIS; IN-VIVO; BARRIER PERMEABILITY; PERITUMORAL EDEMA;
OVARIAN-CARCINOMA
AB Most brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. in addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites.
C1 [Gerstner, Elizabeth R.; Ryg, Peter A.] Massachusetts Gen Hosp, Ctr Canc, Dept Neurol, Ctr Biomarkers & Imaging, Boston, MA 02114 USA.
[Duda, Dan G.; di Tomaso, Emmanuelle; Loeffler, Jay S.; Jain, Rakesh K.] Massachusetts Gen Hosp, Ctr Canc, Dept Radiat Oncol, Ctr Biomarkers & Imaging, Boston, MA 02114 USA.
[Batchelor, Tracy T.] Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, Ctr Biomarkers & Imaging, Boston, MA 02114 USA.
[Ivy, Percy] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
RP Batchelor, TT (reprint author), Massachusetts Gen Hosp, Ctr Neurooncol, Yawkey Bldg,9th Floor,55 Fruit St, Boston, MA 02114 USA.
EM tbatchelor@partners.org
FU NCI NIH HHS [P01 CA080124, R01 CA159258]
NR 62
TC 75
Z9 79
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4774
J9 NAT REV CLIN ONCOL
JI Nat. Rev. Clin. Oncol.
PD APR
PY 2009
VL 6
IS 4
BP 229
EP 236
DI 10.1038/nrclinonc.2009.14
PG 8
WC Oncology
SC Oncology
GA 442PS
UT WOS:000265853700011
PM 19333229
ER
PT J
AU Kraft, P
Wacholder, S
Cornelis, MC
Hu, FB
Hayes, RB
Thomas, G
Hoover, R
Hunter, DJ
Chanock, S
AF Kraft, Peter
Wacholder, Sholom
Cornelis, Marilyn C.
Hu, Frank B.
Hayes, Richard B.
Thomas, Gilles
Hoover, Robert
Hunter, David J.
Chanock, Stephen
TI OPINION Beyond odds - ratios communicating disease risk based on genetic
profiles
SO NATURE REVIEWS GENETICS
LA English
DT Review
ID GENOME-WIDE ASSOCIATION; OPERATING CHARACTERISTIC CURVE;
PROSTATE-CANCER; BREAST-CANCER; ATTRIBUTABLE RISK; LOCI; PREVENTION;
SUSCEPTIBILITY; PREDICTION; RECLASSIFICATION
AB The brisk discovery of novel inherited disease markers by genome-wide association (GWA) studies has raised expectations for predicting disease risk by analysing multiple common alleles. However, the statistics used during the discovery phase of research (such as odds ratios or p values for association) are not the most appropriate measures for evaluating the predictive value of genetic profiles. We argue that other measures - such as sensitivity, specificity, and positive and negative predictive values - are more useful when proposing a genetic profile for risk prediction.
C1 [Kraft, Peter; Hunter, David J.] Harvard Univ, Program Mol & Genet Epidemiol, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Wacholder, Sholom; Hayes, Richard B.; Thomas, Gilles; Hoover, Robert; Hunter, David J.; Chanock, Stephen] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Cornelis, Marilyn C.; Hu, Frank B.; Hunter, David J.] Harvard Univ, Dept Nutr, Sch Publ Hlth, Boston, MA 02115 USA.
[Hunter, David J.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
[Hunter, David J.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
RP Kraft, P (reprint author), Harvard Univ, Program Mol & Genet Epidemiol, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
EM pkraft@hsph.harvard.edu
FU National Institutes of Health [CA098233, DK58845]
FX This work was supported in part by National Institutes of Health grants
CA098233 and DK58845.
NR 57
TC 99
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U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0056
J9 NAT REV GENET
JI Nat. Rev. Genet.
PD APR
PY 2009
VL 10
IS 4
BP 264
EP 269
DI 10.1038/nrg2516
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 420RD
UT WOS:000264306000013
PM 19238176
ER
PT J
AU Moir, S
Fauci, AS
AF Moir, Susan
Fauci, Anthony S.
TI B cells in HIV infection and disease
SO NATURE REVIEWS IMMUNOLOGY
LA English
DT Review
ID IMMUNODEFICIENCY-VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY;
SYSTEMIC-LUPUS-ERYTHEMATOSUS; CD4(+) T-CELLS;
IMMUNE-DEFICIENCY-SYNDROME; CHRONIC VIRAL-INFECTION; PERIPHERAL-BLOOD;
LYMPHOCYTE DYSFUNCTIONS; INFLUENZA VACCINATION; INTERFERON-PRODUCTION
AB In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.
C1 [Moir, Susan; Fauci, Anthony S.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
RP Moir, S (reprint author), NIAID, Immunoregulat Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM smoir@niaid.nih.gov
FU Intramural Research Program of the National Institute of Allergy and
Infectious Diseases; National Institutes of Health, USA
FX We thank T. W. Chun, J. Chen and A. Waldner for suggestions on the
manuscript and help with the figures. This work was supported by the
Intramural Research Program of the National Institute of Allergy and
Infectious Diseases, National Institutes of Health, USA.
NR 122
TC 318
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U1 8
U2 46
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1474-1733
J9 NAT REV IMMUNOL
JI Nat. Rev. Immunol.
PD APR
PY 2009
VL 9
IS 4
BP 235
EP 245
DI 10.1038/nri2524
PG 11
WC Immunology
SC Immunology
GA 423MT
UT WOS:000264501100013
PM 19319142
ER
PT J
AU Misteli, T
Soutoglou, E
AF Misteli, Tom
Soutoglou, Evi
TI The emerging role of nuclear architecture in DNA repair and genome
maintenance
SO NATURE REVIEWS MOLECULAR CELL BIOLOGY
LA English
DT Review
ID DOUBLE-STRAND BREAKS; HISTONE ACETYLTRANSFERASE HAT1P; CHROMATIN
REMODELING COMPLEX; DAMAGE RESPONSE; SACCHAROMYCES-CEREVISIAE;
CELL-CYCLE; MRE11-RAD50-NBS1 COMPLEX; CHROMOSOME TERRITORIES; H2AX
PHOSPHORYLATION; SPATIAL-ORGANIZATION
AB DNA repair and maintenance of genome stability are crucial to cellular and organismal function, and defects in these processes have been implicated in cancer and ageing. Detailed molecular, biochemical and genetic analyses have outlined the molecular framework involved in cellular DNA-repair pathways, but recent cell-biological approaches have revealed important roles for the spatial and temporal organization of the DNA-repair machinery during the recognition of DNA lesions and the assembly of repair complexes. It has also become clear that local higher-order chromatin structure, chromatin dynamics and non-random global genome organization are key factors in genome maintenance. These cell-biological features of DNA repair illustrate an emerging role for nuclear architecture in multiple aspects of genome maintenance.
C1 [Misteli, Tom] NCI, NIH, Bethesda, MD 20892 USA.
[Soutoglou, Evi] Inst Genet & Biol Mol & Cellulaire, Dept Canc Biol, INSERM U 596, CNRS UMR 7104, Strasbourg, France.
RP Misteli, T (reprint author), NCI, NIH, Bethesda, MD 20892 USA.
EM mistelit@mail.nih.gov; evisou@igbmc.fr
FU National Institutes of Health; National Cancer Institute; Center for
Cancer Research; National Centre for Scientific Research and Institute
of Genetics and Molecular and Cellular Biology
FX We thank V. Roukos for critically reading the manuscript. Misteli's
laboratory is supported by the Intramural Research Program of the
National Institutes of Health, National Cancer Institute and Center for
Cancer Research. Soutoglou's laboratory is supported by the National
Centre for Scientific Research and Institute of Genetics and Molecular
and Cellular Biology.
NR 124
TC 237
Z9 239
U1 2
U2 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0072
J9 NAT REV MOL CELL BIO
JI Nat. Rev. Mol. Cell Biol.
PD APR
PY 2009
VL 10
IS 4
BP 243
EP 254
DI 10.1038/nrm2651
PG 12
WC Cell Biology
SC Cell Biology
GA 422FS
UT WOS:000264413500011
PM 19277046
ER
PT J
AU Gould, GW
Lippincott-Schwartz, J
AF Gould, Gwyn W.
Lippincott-Schwartz, Jennifer
TI New roles for endosomes: from vesicular carriers to multi-purpose
platforms
SO NATURE REVIEWS MOLECULAR CELL BIOLOGY
LA English
DT Review
ID PLASMA-MEMBRANE; CLEAVAGE FURROW; SIGNAL-TRANSDUCTION; ESCRT MACHINERY;
CELL POLARITY; CYTOKINESIS; TRAFFICKING; DROSOPHILA; MIDBODY; EXOCYST
AB The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.
C1 [Gould, Gwyn W.] Univ Glasgow, Fac Biomed & Life Sci, Div Mol & Cellular Biol, Henry Wellcome Lab Cell Biol, Glasgow G12 8QQ, Lanark, Scotland.
[Lippincott-Schwartz, Jennifer] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA.
RP Gould, GW (reprint author), Univ Glasgow, Fac Biomed & Life Sci, Div Mol & Cellular Biol, Henry Wellcome Lab Cell Biol, Davidson Bldg, Glasgow G12 8QQ, Lanark, Scotland.
EM g.gould@bio.gla.ac.uk; lippincj@mail.nih.gov
OI Gould, Gwyn/0000-0001-6571-2875
FU Wellcome Trust; Biotechnology and Biological Sciences Research Council;
Cancer Research UK; Association for International Cancer Research
FX Work in the G. W. G. laboratory is supported by grants from the Wellcome
Trust and the Biotechnology and Biological Sciences Research Council,
Cancer Research UK and the Association for International Cancer
Research. G. W. G. thanks C. Isacke and N. Bryant for helpful comments
on the manuscript.
NR 50
TC 112
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U1 1
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0072
J9 NAT REV MOL CELL BIO
JI Nat. Rev. Mol. Cell Biol.
PD APR
PY 2009
VL 10
IS 4
BP 287
EP 292
DI 10.1038/nrm2652
PG 6
WC Cell Biology
SC Cell Biology
GA 422FS
UT WOS:000264413500016
PM 19277045
ER
PT J
AU Turkbey, B
Pinto, PA
Choyke, PL
AF Turkbey, Baris
Pinto, Peter A.
Choyke, Peter L.
TI Imaging techniques for prostate cancer: implications for focal therapy
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID POSITRON-EMISSION-TOMOGRAPHY; CONTRAST-ENHANCED MRI; DIFFUSION-WEIGHTED
MRI; EXTERNAL-BEAM RADIOTHERAPY; IN-111 CAPROMAB PENDETIDE; STEP-SECTION
HISTOLOGY; RADICAL PROSTATECTOMY; ENDORECTAL MR; MONOCLONAL-ANTIBODY;
TRANSRECTAL ULTRASONOGRAPHY
AB The multifocal nature of prostate cancer has necessitated whole-gland therapy in the past; however, since the widespread use of PSA screening, patients frequently present with less-advanced disease. Many men with localized disease wish to avoid the adverse effects of whole-gland therapy; therefore, focal therapy for prostate cancer is being considered as a treatment option. For focal treatment to be viable, accurate imaging is required for diagnosis, staging, and monitoring of treatment. Developments in MRI and PET have brought more attention to prostate imaging and the possibility of improving the accuracy of focal therapy. in this review, we discuss the advantages and disadvantages of conventional methods for imaging the prostate, new developments for targeted imaging, and the possible role of image-guided biopsy and therapy for localized prostate cancer.
C1 [Choyke, Peter L.] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA.
RP Choyke, PL (reprint author), NCI, Mol Imaging Program, NIH, 10 Ctr Dr,MSC 1182,Bldg 10,Room 1B40, Bethesda, MD 20892 USA.
EM pchoyke@nih.gov
FU Intramural NIH HHS [Z01 BC010655-04]
NR 98
TC 88
Z9 92
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4812
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD APR
PY 2009
VL 6
IS 4
BP 191
EP 203
DI 10.1038/nrurol.2009.27
PG 13
WC Urology & Nephrology
SC Urology & Nephrology
GA 442QL
UT WOS:000265855600006
PM 19352394
ER
PT J
AU Bayfield, MA
Maraia, RJ
AF Bayfield, Mark A.
Maraia, Richard J.
TI Precursor-product discrimination by La protein during tRNA metabolism
SO NATURE STRUCTURAL & MOLECULAR BIOLOGY
LA English
DT Article
ID METHIONYL-TRANSFER-RNA; POLYMERASE-III; NUCLEAR TRAFFICKING;
STRUCTURAL-ANALYSIS; CHAPERONE ACTIVITY; NASCENT RNA; 7SK SNRNP; P-TEFB;
MATURATION; BINDING
AB La proteins bind pre-tRNAs at their UUU-3'OH ends, facilitating their maturation. Although the mechanism by which La binds pre-tRNA 3' trailers is known, the function of the RNA binding beta-sheet surface of the RNA-recognition motif (RRM1) is unknown. How La dissociates from UUU-3'OH-containing trailers after 3' processing is also unknown. Here we show that La preferentially binds pre-tRNAs over processed tRNAs or 3' trailer products through coupled use of two sites: one on the La motif and another on the RRM1 beta-surface that binds elsewhere on tRNA. Two sites provide stable pre-tRNA binding, whereas the processed tRNA and 3' trailer are released from their single sites relatively fast. RRM1 loop-3 mutations decrease affinity for pre-tRNA and tRNA, but not for the UUU-3'OH trailer, and impair tRNA maturation in vivo. We propose that RRM1 functions in activities that are more complex than UUU-3'OH binding. Accordingly, the RRM1 mutations also impair an RNA chaperone activity of La. The results suggest how La distinguishes precursor from product RNAs, allowing it to recycle onto a new pre-tRNA.
C1 [Bayfield, Mark A.; Maraia, Richard J.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Intramural Res Program, NIH, Bethesda, MD USA.
[Maraia, Richard J.] US PHS, Commissioned Corps, Bethesda, MD USA.
RP Maraia, RJ (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Intramural Res Program, NIH, Bethesda, MD USA.
EM maraiar@mail.nih.gov
FU US National Institute of Child Health and Human Development, National
Institutes of Health
FX We thank D. Setzer for advice, protocols and RNA binding data analysis
tools, M. Nashimoto ( Niigata University of Pharmacy and Applied Life
Sciences) for the human tRNAArgACG gene and R. Schroeder ( University of
Vienna) for cis-splicing intron DNA. We thank D. Setzer, D. Engelke and
M. Teplova for comments. This work was supported by the Intramural
Research Program of the US National Institute of Child Health and Human
Development, National Institutes of Health.
NR 49
TC 26
Z9 26
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1545-9985
J9 NAT STRUCT MOL BIOL
JI Nat. Struct. Mol. Biol.
PD APR
PY 2009
VL 16
IS 4
BP 430
EP 437
DI 10.1038/nsmb.1573
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 429AD
UT WOS:000264892300016
PM 19287396
ER
PT J
AU Mahringer, A
Seymour, A
Miller, DS
Fricker, G
AF Mahringer, A.
Seymour, A.
Miller, D. S.
Fricker, G.
TI Arylhydrocarbon receptor-dependent regulation of the ABC transporters
BCRP, MRP2 and P-gp in kidney tubules from killifish (Fundulus
heteroclitus)
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Meeting Abstract
CT 50th Annual Meeting of the
Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und
-Toxikologie
CY MAR 10-12, 2009
CL Mainz, GERMANY
SP Deutsch Gesell Experiment & Klinis Pharmakol & Toxikol
C1 [Mahringer, A.; Seymour, A.; Miller, D. S.; Fricker, G.] Mt Desert Isl Biol Lab, Salsbury Cove, ME USA.
[Mahringer, A.; Fricker, G.] Univ Heidelberg, Dept Pharmaceut Technol & Biopharm, Heidelberg, Germany.
[Seymour, A.; Miller, D. S.] NIEHS, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
MA 8
BP 9
EP 9
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 452TD
UT WOS:000266563200009
ER
PT J
AU Londono, JEC
Meissner, M
Dietrich, A
Birnbaumer, L
Flockerzi, V
Freichel, M
AF Londono, Camacho J. E.
Meissner, M.
Dietrich, A.
Birnbaumer, L.
Flockerzi, V
Freichel, M.
TI Analysis of cardiac hypertrophy induced by isoproterenol or angiotensin
II in TRPC-deficient mice
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Meeting Abstract
CT 50th Annual Meeting of the
Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und
-Toxikologie
CY MAR 10-12, 2009
CL Mainz, GERMANY
SP Deutsch Gesell Experiment & Klinis Pharmakol & Toxikol
C1 [Londono, Camacho J. E.; Meissner, M.; Flockerzi, V; Freichel, M.] Univ Saarland, Homburg, Germany.
[Dietrich, A.] Univ Marburg, Marburg, Germany.
[Birnbaumer, L.] NIEHS, Transmembrane Signaling Grp, Res Triangle Pk, NC 27709 USA.
RI Dietrich, Alexander/G-8619-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
MA 130
BP 31
EP 31
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 452TD
UT WOS:000266563200131
ER
PT J
AU Londono, JEC
Meissner, M
Dietrich, A
Birnbaumer, L
Flockerzi, V
Freichel, M
AF Londono, Camacho J. E.
Meissner, M.
Dietrich, A.
Birnbaumer, L.
Flockerzi, V
Freichel, M.
TI Analysis of the role of TRPC proteins for platelet aggregation in mice
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Meeting Abstract
CT 50th Annual Meeting of the
Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und
-Toxikologie
CY MAR 10-12, 2009
CL Mainz, GERMANY
SP Deutsch Gesell Experiment & Klinis Pharmakol & Toxikol
C1 [Londono, Camacho J. E.; Meissner, M.; Flockerzi, V; Freichel, M.] Univ Saarland, D-66421 Homburg, Germany.
[Dietrich, A.] Univ Marburg, D-35043 Marburg, Germany.
[Birnbaumer, L.] NIEHS, Transmembrane Signaling Grp, Res Triangle Pk, NC 27709 USA.
RI Dietrich, Alexander/G-8619-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
MA 141
BP 33
EP 33
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 452TD
UT WOS:000266563200142
ER
PT J
AU Benndorf, RA
Maas, R
Xanthakis, V
Polak, J
Schwedhelm, E
Wolf, PA
Sullivan, LM
Vasan, RS
Boger, RH
Seshadri, S
AF Benndorf, R. A.
Maas, R.
Xanthakis, V.
Polak, J.
Schwedhelm, E.
Wolf, P. A.
Sullivan, L. M.
Vasan, R. S.
Boeger, R. H.
Seshadri, S.
TI Association of asymmetric dimethylarginine (ADMA) with carotid artery
intimal media thickness in the Framingham heart study offspring cohort
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Meeting Abstract
CT 50th Annual Meeting of the
Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und
-Toxikologie
CY MAR 10-12, 2009
CL Mainz, GERMANY
SP Deutsch Gesell Experiment & Klinis Pharmakol & Toxikol
C1 [Benndorf, R. A.; Schwedhelm, E.; Boeger, R. H.] Univ Med Ctr Hamburg Eppendorf, Clin Pharmacol Unit, Inst Expt & Clin Pharmacol, Hamburg, Germany.
[Maas, R.] Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, D-8520 Erlangen, Germany.
[Xanthakis, V.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
[Polak, J.] Tufts Univ New England Med Ctr, Dept Radiol, Boston, MA USA.
[Wolf, P. A.; Sullivan, L. M.; Vasan, R. S.] NHLBI, Framingham Heart Study, Framingham, MA USA.
[Vasan, R. S.; Seshadri, S.] Boston Univ, Sch Med, Boston, MA 02118 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
MA 461
BP 91
EP 91
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 452TD
UT WOS:000266563200462
ER
PT J
AU Jositsch, G
Papadakis, T
Haberberger, RV
Wolff, M
Wess, J
Kummer, W
AF Jositsch, Gitte
Papadakis, Tamara
Haberberger, Rainer V.
Wolff, Miriam
Wess, Juergen
Kummer, Wolfgang
TI Suitability of muscarinic acetylcholine receptor antibodies for
immunohistochemistry evaluated on tissue sections of receptor
gene-deficient mice
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Acetylcholine; Muscarinic receptor; Immunohistochemistry; Specificity;
Receptor knockout strains; Mouse
ID DORSAL-ROOT GANGLIA; URINARY-BLADDER; SMOOTH-MUSCLE; KNOCKOUT MICE;
EXPRESSION; RAT; UROTHELIUM; BINDING; HYPERREACTIVITY; DETRUSOR
AB Acetylcholine (ACh) is a major regulator of visceral function exerting pharmacologically relevant effects upon smooth muscle tone and epithelial function via five types of muscarinic receptors (M1R-M5R). In this paper, we assessed the specificity of muscarinic receptor (MR) antibodies in immunohistochemical labelling on tissue sections by analysing specimens from wild-type and respective gene-deficient mice. Of 24 antibodies evaluated in this study, 16 were tested at 18 different conditions each, and eight of them in 21 different protocols, resulting in a total number of 456 antibody/protocol combinations. Each of them was tested at four antibody dilutions at minimum, so that finally, at least 1,824 conditions were evaluated. For each of them, dorsal root ganglia, urinary bladder and cross-sections through all thoracic viscera were investigated. In all cases where the antigen was available, at least one incubation condition was identified in which only select cell types were immunolabelled in the positive control but remained unlabelled in the pre-absorption control. With two exceptions (M2R antibodies), however, all antibodies produced identical immunohistochemical labelling patterns in tissues taken from corresponding gene-deficient mice even when the pre-absorption control in wild-type mice suggested specificity. Hence, the present data demonstrate the unpleasant fact that reliable immunohistochemical localisation of MR subtypes with antibodies is the exception rather than the rule. Immunohistochemical detection of MR subtype localisation in tissue sections of peripheral organs is limited to the M2R subtype utilising the most commonly used methodological approaches.
C1 [Jositsch, Gitte; Papadakis, Tamara; Wolff, Miriam; Kummer, Wolfgang] Univ Giessen, Inst Anat & Cell Biol, D-35385 Giessen, Germany.
[Haberberger, Rainer V.] Flinders Univ S Australia, Dept Anat & Histol, Adelaide, SA, Australia.
[Wess, Juergen] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA.
RP Kummer, W (reprint author), Univ Giessen, Inst Anat & Cell Biol, D-35385 Giessen, Germany.
EM wolfgang.kummer@anatomie.med.uni-giessen.de
RI Scholz, Andreas/J-8595-2013;
OI Haberberger, Rainer Viktor/0000-0001-8043-3786
FU DFG [KO 1398/5-1]
FX We thank Ms K. Michael for skilful help in preparing the figures. Thus
study was supported by the DFG (Excellence Cluster Cardio-Pulmonary
System and KO 1398/5-1).
NR 24
TC 74
Z9 74
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
IS 4
BP 389
EP 395
DI 10.1007/s00210-008-0365-9
PG 7
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 423KF
UT WOS:000264494500008
PM 18974978
ER
PT J
AU Pizzarelli, F
Lauretani, F
Bandinelli, S
Windham, GB
Corsi, AM
Giannelli, SV
Ferrucci, L
Guralnik, JM
AF Pizzarelli, Francesco
Lauretani, Fulvio
Bandinelli, Stefania
Windham, Gwen B.
Corsi, Anna Maria
Giannelli, Sandra V.
Ferrucci, Luigi
Guralnik, Jack M.
TI Predictivity of survival according to different equations for estimating
renal function in community-dwelling elderly subjects
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE Cockcroft-Gault formula; elderly; MDRD equations; mortality;
population-based study
ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; COCKCROFT-GAULT
EQUATIONS; SERUM CREATININE VALUES; BODY-MASS INDEX; POSITION STATEMENT;
BLOOD-PRESSURE; HEART-FAILURE; RISK-FACTOR; PREVALENCE
AB Background. Detection of subjects with early chronic kidney disease (CKD) is important because some will progress up to stage 5 CKD, and most are at high risk of cardiovascular morbidity and mortality. While validity and precision of estimated glomerular filtration rate (eGFR) equations in tracking true GFR have been repeatedly investigated, their prognostic performance for mortality has not been hitherto compared. This is especially relevant in an elderly population in whom the risk of death is far more common than progression.
Methods. We analysed data of participants in the InCHIANTI study, a community-based cohort study of older adults. Twenty-four-hour creatinine clearance (Ccr), Cockcroft-Gault (C-G) and Modification of Diet in Renal Disease (MDRD)-derived equations (six and four input variables) were calculated at enrolment (1998-2000), and all-cause mortality and cardiovascular mortality were prospectively ascertained by Cox regression over a 6-year follow-up.
Results. Of the 1270 participants, 942 (mean age 75 years) had complete data for this study. The mean renal function ranged from 77 ml/min/1.73 m(2) by Ccr to 64 ml/min/1.73 m(2) by C-G. Comparisons among equations using K/DOQI staging highlight relevant mismatches, with a prevalence of CKD ranging from 22% (MDRD-4) to 40% (C-G). Reduced renal function was a strong independent predictor of death. In a Cox model-adjusted for demographics, physical activity, comorbidities, proteinuria and inflammatory parameters-participants with Ccr 60-90 ml/min/1.73 m(2) and Ccr <60 ml/min/1.73 m(2) were, respectively, 1.70 (95% CI: 1.02-2.83) and 1.91 (95% CI: 1.11-3.29) times more likely to die over the follow-up compared to those with Ccr >90 ml/min/1.73 m(2). For the C-G, the group with values <60 ml/min/1.73 m(2) had a significant higher all-cause mortality compared to those with values >90 ml/min/1.73 m(2) (HR 2.59, 95% CI: 1.13-5.91). The classification based on the MDRD formulae did not provide any significant prognostic information. The adjusted risk of all-cause mortality followed a similar pattern when Ccr and estimating equations were introduced as continuous variables or dichotomized as higher or lower than 60 ml/min. C-G was the best prognostic indicator of cardiovascular mortality. Possibly, Ccr and C-G are better prognostic indicators than MDRD-derived equations because they incorporate a stronger effect of age.
Conclusions. In a South-European elderly population, the prevalence of CKD is high and varies widely according to the method adopted to estimate GFR. Researchers and clinicians who want to capture the prognostic information on mortality related to kidney function should use the Ccr or C-G formula and not MDRD equations. These results highlight the importance of strategies for early detection and clinical management of CKD in elderly subjects.
C1 [Giannelli, Sandra V.; Guralnik, Jack M.] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA.
[Corsi, Anna Maria] Univ Florence, Multidisciplinary Ctr Res Food Sci GRA, Dept Med & Surg Crit Care, Florence, Italy.
[Windham, Gwen B.; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA.
[Lauretani, Fulvio; Corsi, Anna Maria] Tuscany Hlth Reg Agcy, Florence, Italy.
[Bandinelli, Stefania] Div Geriatr, Florence, Italy.
[Pizzarelli, Francesco] SM Annunziata Hosp, Div Nephrol, I-50011 Florence, Italy.
RP Pizzarelli, F (reprint author), SM Annunziata Hosp, Nephrol & Dialysis Unit, Via Antella 58, I-50011 Florence, Italy.
EM fpizzarelli@yahoo.com
RI Giannelli, Sandra/E-8637-2011; Lauretani, Fulvio/K-5115-2016
OI Lauretani, Fulvio/0000-0002-5287-9972
FU National Institute on Aging [N01-AG-916413, N01-AG-821336,
N01-AG-5-0002, R01 AG027012]; Intramural Research Program; NIH
FX This work was supported by National Institute on Aging Contracts
N01-AG-916413, N01-AG-821336, N01-AG-5-0002, NIA Grant R01 AG027012, and
supported in part by the Intramural Research Program, National Institute
on Aging, NIH.
NR 50
TC 33
Z9 34
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD APR
PY 2009
VL 24
IS 4
BP 1197
EP 1205
DI 10.1093/ndt/gfn594
PG 9
WC Transplantation; Urology & Nephrology
SC Transplantation; Urology & Nephrology
GA 422AG
UT WOS:000264398800022
PM 18988669
ER
PT J
AU Bagnasco, SM
Mohammed, BS
Mani, H
Gandolfo, MT
Haas, M
Racusen, LC
Montgomery, RA
Kraus, E
AF Bagnasco, Serena M.
Mohammed, Basim S.
Mani, Haresh
Gandolfo, Maria Teresa
Haas, Mark
Racusen, Lorraine C.
Montgomery, Robert A.
Kraus, Edward
TI Oxalate deposits in biopsies from native and transplanted kidneys, and
impact on graft function
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE allograft function; kidney transplant; oxalate; rejection
ID GLOMERULAR-FILTRATION-RATE; RENAL-ALLOGRAFT PATHOLOGY; URINARY OXALATE;
FAILURE; CLASSIFICATION; HYPEROXALURIA; REJECTION; EQUATIONS; EXCRETION;
SURVIVAL
AB Background. The purpose of this study was to examine the incidence of oxalate deposits in native and renal allograft biopsies, and its impact on graft function.
Methods. The renal biopsy files at The Johns Hopkins University between 2000 and 2006 were searched to identify biopsies with oxalate deposits, determine the density of oxalate deposits in renal graft biopsies, compare graft histology and function between allograft recipients with oxalate in the graft biopsies, and a control group of recipients without oxalate in the graft.
Results. Oxalate crystal deposits were observed in 61 of 5160 biopsies of native kidneys, and in 76 of 1621 renal allograft biopsies, with a frequency of 1 and 4%, respectively. Sixty-three (9%) of 680 transplant recipients showed oxalate in graft biopsies obtained within the first year from transplantation, with 1.3 +/- 1.2 average number of oxalate deposits per mm(2) of biopsy tissue. The high oxalate density and decreased renal function were correlated in the first 2 years post-transplant (P = 0.037-0.05). Compared with a control group of 70 kidney graft recipients, the renal function was significantly lower in the oxalate group at 1 year, but not at 2 years post-transplant. High tubulo-interstitial scarring (P < 0.0001) was noted in repeated biopsies in the oxalate group, and was significantly greater than that in the control group (P = 0.027). No significant difference in graft loss was observed between oxalate and control groups, and although mortality was higher in the oxalate group, the difference was not significant.
Conclusions. In summary, this study defines the frequency of oxalate deposition in native and allograft kidney biopsies, and suggests its possible negative impact on graft function beyond the early post-transplant period.
C1 [Bagnasco, Serena M.; Mohammed, Basim S.; Gandolfo, Maria Teresa; Haas, Mark; Racusen, Lorraine C.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA.
[Mani, Haresh] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
[Montgomery, Robert A.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21287 USA.
[Kraus, Edward] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA.
RP Bagnasco, SM (reprint author), Johns Hopkins Univ Hosp, Dept Pathol, Ross Bldg,Room 632,720 Rutland St, Baltimore, MD 21205 USA.
EM sbagnas1@jhmi.edu
NR 20
TC 8
Z9 8
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD APR
PY 2009
VL 24
IS 4
BP 1319
EP 1325
DI 10.1093/ndt/gfn697
PG 8
WC Transplantation; Urology & Nephrology
SC Transplantation; Urology & Nephrology
GA 422AG
UT WOS:000264398800042
PM 19103737
ER
PT J
AU Chandramohan, V
Kuan, CT
Pegram, CN
Pastan, I
Bigner, DD
AF Chandramohan, Vidyalakshmi
Kuan, Chien-Tsun
Pegram, Charles N.
Pastan, Ira
Bigner, Darell D.
TI DUAL-SPECIFIC IMMUNOTOXIN, D2C7 (SCDSFV)-PE38KDEL, FOR BRAIN TUMOR
TREATMENT
SO NEURO-ONCOLOGY
LA English
DT Meeting Abstract
CT 17th International Conference on Brain Tumor Research and Therapy
CY JUN 09-12, 2008
CL Tokyo, JAPAN
C1 [Chandramohan, Vidyalakshmi; Kuan, Chien-Tsun; Pegram, Charles N.; Bigner, Darell D.] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC USA.
[Pastan, Ira] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1522-8517
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD APR
PY 2009
VL 11
IS 2
BP 223
EP 223
PG 1
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA 430MS
UT WOS:000264993800040
ER
PT J
AU Kuan, CT
Wakiya, K
Herndon, JE
Wikstrand, CJ
McLendon, RE
Zalutsky, MR
Pastan, IH
Bigner, DD
AF Kuan, Chien-Tsun
Wakiya, Kenji
Herndon, James E., II
Wikstrand, Carol J.
McLendon, Roger E.
Zalutsky, Michael R.
Pastan, Ira H.
Bigner, Darell D.
TI RECOMBINANT ANTIBODY-BASED MOLECULAR THERAPEUTICS FOR BRAIN TUMOR
IMMUNOTHERAPY
SO NEURO-ONCOLOGY
LA English
DT Meeting Abstract
CT 17th International Conference on Brain Tumor Research and Therapy
CY JUN 09-12, 2008
CL Tokyo, JAPAN
C1 [Kuan, Chien-Tsun; Wakiya, Kenji; Herndon, James E., II; Wikstrand, Carol J.; McLendon, Roger E.; Zalutsky, Michael R.; Bigner, Darell D.] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC USA.
[Pastan, Ira H.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1522-8517
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD APR
PY 2009
VL 11
IS 2
BP 224
EP 224
PG 1
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA 430MS
UT WOS:000264993800041
ER
PT J
AU Schiff, D
Sarkaria, J
Decker, P
Buckner, J
Galanis, E
Dancey, J
Giannini, C
Brown, P
Wiesenfeld, M
Jaeckle, K
AF Schiff, David
Sarkaria, Jann
Decker, Paul
Buckner, Jan
Galanis, Evanthia
Dancey, Janet
Giannini, Caterina
Brown, Paul
Wiesenfeld, Martin
Jaeckle, Kurt
TI FEASIBILITY/TOLERABILITY RESULTS FROM A PHASE I/II STUDY OF TEMSIROLIMUS
(CCI-779) AND SORAFENIB IN RECURRENT GLIOBLASTOMA: NORTH CENTRAL CANCER
TREATMENT GROUP (NCCTG) N0572
SO NEURO-ONCOLOGY
LA English
DT Meeting Abstract
CT 17th International Conference on Brain Tumor Research and Therapy
CY JUN 09-12, 2008
CL Tokyo, JAPAN
C1 [Schiff, David] Univ Virginia, Neurooncol Ctr, Charlottesville, VA USA.
[Sarkaria, Jann; Decker, Paul; Buckner, Jan; Galanis, Evanthia; Giannini, Caterina; Brown, Paul; Jaeckle, Kurt] Mayo Clin, Rochester, MN USA.
[Dancey, Janet] NCI, Bethesda, MD 20892 USA.
[Wiesenfeld, Martin] Cedar Rapids Oncol Project CCOP, Cedar Rapids, IA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1522-8517
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD APR
PY 2009
VL 11
IS 2
BP 232
EP 232
PG 1
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA 430MS
UT WOS:000264993800076
ER
PT J
AU Wen, P
Chang, S
Kuhn, J
Lamborn, K
Robins, HI
Yung, A
Gilbert, MR
Cloughesy, T
Lieberman, F
DeAngelis, L
Abrey, L
Drappatz, J
Kesari, S
Dancey, J
Prados, MD
AF Wen, Patrick
Chang, Susan
Kuhn, John
Lamborn, Kathleen
Robins, H. Ian
Yung, Alfred
Gilbert, Mark R.
Cloughesy, Timothy
Lieberman, Frank
DeAngelis, Lisa
Abrey, Lauren
Drappatz, Jan
Kesari, Santosh
Dancey, Janet
Prados, Michel D.
TI PHASE I/II STUDY OF ERLOTINIB AND CCI-779 (TEMSIROLIMUS) FOR PATIENTS
WITH RECURRENT MALIGNANT GLIOMAS (NABTC 04-02)
SO NEURO-ONCOLOGY
LA English
DT Meeting Abstract
CT 17th International Conference on Brain Tumor Research and Therapy
CY JUN 09-12, 2008
CL Tokyo, JAPAN
C1 [Wen, Patrick; Drappatz, Jan; Kesari, Santosh] Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA.
[Chang, Susan; Lamborn, Kathleen; Prados, Michel D.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Kuhn, John] Univ Texas San Antonio, San Antonio, TX USA.
[Yung, Alfred; Gilbert, Mark R.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Cloughesy, Timothy] Univ Calif Los Angeles, Los Angeles, CA USA.
[Robins, H. Ian] Univ Wisconsin, Madison, WI USA.
[DeAngelis, Lisa; Abrey, Lauren] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Lieberman, Frank] Univ Pittsburgh, Pittsburgh, PA USA.
[Dancey, Janet] NCI, Bethesda, MD 20892 USA.
RI Kesari, Santosh/E-8461-2013; Gilbert, Mark/J-7494-2016
OI Gilbert, Mark/0000-0003-2556-9722
NR 0
TC 1
Z9 1
U1 0
U2 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1522-8517
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD APR
PY 2009
VL 11
IS 2
BP 232
EP 232
PG 1
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA 430MS
UT WOS:000264993800077
ER
PT J
AU de Jong, FJ
Masaki, K
Chen, HP
Remaley, AT
Breteler, MMB
Petrovitch, H
White, LR
Launer, LJ
AF de Jong, Frank Jan
Masaki, Karnal
Chen, Hepei
Remaley, Alan T.
Breteler, Monique M. B.
Petrovitch, Helen
White, Lon R.
Launer, Lenore J.
TI Thyroid function, the risk of dementia and neuropathologic changes: The
Honolulu-Asia Aging Study
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Epidemiology; Thyroid hormones; Thyrotropin; Total thyroxine; Free
thyroxine; Dementia; Alzheimer's disease; Neuropathology; Neuritic
plaques; Neurofibrillary tangles
ID JAPANESE-AMERICAN MEN; ALZHEIMERS-DISEASE; STIMULATING HORMONE; GENE;
DIAGNOSIS; CRITERIA; AD; ASSOCIATION; CALIFORNIA; HEALTH
AB Thyroid dysfunction is associated with cognitive impairment and dementia, including Alzheimer's disease (AD). It remains unclear whether thyroid dysfunction results from, or contributes to, Alzheimer pathology. We determined whether thyroid function is associated with dementia, specifically AD, and Alzheimer-type neuropathology in a prospective population-based cohort of Japanese-American men. Thyrotropin, total and free thyroxine were available in 665 men aged 71-93 years and dementia-free at baseline (1991), including 143 men who participated in an autopsy sub-study. During a mean follow-up of 4.7 (S.D.: 1.8) years, 106 men developed dementia of whom 74 had AD. Higher total and free thyroxine levels were associated with an increased risk of dementia and AD (age and sex adjusted hazard ratio (95% confidence interval) per S.D. increase in free thyroxine: 1.21 (1.04; 1.40) and 1.31 (1.14; 1.51), respectively). In the autopsied sub-sample, higher total thyroxine was associated with higher number of neocortical neuritic plaques and neurofibrillary tangles. No associations were found for thyrotropin. Our findings suggest that higher thyroxine levels are present with Alzheimer clinical disease and neuropathology. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Chen, Hepei; Launer, Lenore J.] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA.
[Breteler, Monique M. B.] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands.
[Masaki, Karnal; Petrovitch, Helen; White, Lon R.] Pacific Hlth Res Inst, Honolulu, HI 96813 USA.
[Remaley, Alan T.] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
[de Jong, Frank Jan] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands.
RP Launer, LJ (reprint author), NIA, Lab Epidemiol Demog & Biometry, NIH, 7201 Wisconsin Ave,3C-309, Bethesda, MD 20892 USA.
EM f.j.dejong@erasmusmc.nl; khmasaki@phrihawaii.org; chenhep@mail.nih.gov;
ARemaley@cc.nih.gov; m.breteler@erasmusmc.nl;
hpetrovitch@phrihawaii.org; lrwhite@prhihawaii.org; launerl@nia.nih.gov
RI Breteler, Monique /J-5058-2014
FU National Institute on Aging [N01-AG-4-2149, UO1-AG-0-9349-03,
RO1-AG-0-7155-06A1]; National Heart Lung and Blood Institute
[N01-HC-0-5102]; International Foundation of Alzheimer Research (ISAO)
[01500]; Netherlands Organization for Health Research and Development
[904-61-155]
FX The Honolulu-Asia Aging Study is supported by the National Institute on
Aging (contract # N01-AG-4-2149, grant# UO1-AG-0-9349-03 and
RO1-AG-0-7155-06A1), the National Heart Lung and Blood Institute
(contract # N01-HC-0-5102), and by the Intramural Research Program of
the National Institute on Aging. This research was also made possible in
part by grants from the International Foundation of Alzheimer Research
(ISAO grant 01500) and the Netherlands Organization for Health Research
and Development (ZonMW, grant 904-61-155).
NR 34
TC 45
Z9 46
U1 1
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD APR
PY 2009
VL 30
IS 4
BP 600
EP 606
DI 10.1016/j.neurobiolaging.2007.07.019
PG 7
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 424PT
UT WOS:000264579500015
PM 17870208
ER
PT J
AU Yaffe, K
Lindquist, K
Sen, S
Cauley, J
Ferrell, R
Penninx, B
Harris, T
Li, RL
Cummings, SR
AF Yaffe, Kristine
Lindquist, Karla
Sen, Saunak
Cauley, Jane
Ferrell, Robert
Penninx, Brenda
Harris, Tamara
Li, Rongling
Cummings, Steven R.
CA Hlth ABC Study
TI Estrogen receptor genotype and risk of cognitive impairment in elders:
Findings from the Health ABC study
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Estrogen; Dementia; Genetics; Aging
ID ALPHA GENE POLYMORPHISMS; SPORADIC ALZHEIMERS-DISEASE;
CENTRAL-NERVOUS-SYSTEM; POSTMENOPAUSAL WOMEN; CAUCASIAN WOMEN;
MESSENGER-RNA; HUMAN BRAIN; ASSOCIATION; BETA; ESR1
AB Objective: To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women.
Background: Several single nucleotide polymorphisms (SNPs) on ESR1 and ESR2 genes have been associated with a range of hormone sensitive diseases such as breast cancer and osteoporosis. Genetic variations in ESR may also influence cognitive aging but are less studied, especially among men.
Methods: We studied 2527 participants enrolled in an ongoing prospective study of community-dwelling elders. Four SNPs from ESR1 and four from ESR2 were analyzed. We measured cognitive function with the Modified Mini-Mental Status Examination (3MS) at baseline and biannually cognitive impairment was defined as it decline of live or more points over 4 years. We calculated odds of developing cognitive impairment across SNPS using gender-stratified logistic regression and adjusted analyses for age, education, baseline 3MS score and in addition for race.
Results: One thousand three hundred and forty-three women (mean age 73.4) and 1184 men (mean age 73.7) comprised Our cohort. Among women, after multivariate adjustment, two of the ESR1 SNPs (rs8179176, rs9340799) and two of the ESR2 SNPs (rs1256065, rs1256030) were associated with likelihood of developing cognitive impairment., although the association for rs8179176 was of trend level significance. In men, one of the ESR1 SNPs (rs729524) and two of the ESR2 (rs1255998, rs1256030) were associated with cognitive impairment. Further adjustment for race attenuated the results somewhat. There was no association between any ESR SNP and level of bioavailable estradiol but testosterone level did vary among two of the SNPs (p < 0.05).
Conclusion: We found that among non-demented Community elders, several SNPs in the ESR1 and ESR2 genes were associated with risk of developing cognitive impairment. These findings suggest that estrogen receptor genetic variants may play it role in cognitive aging. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat & Neurol, Sch Med, San Francisco, CA 94121 USA.
[Yaffe, Kristine; Sen, Saunak] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Lindquist, Karla] Univ Calif San Francisco, Dept Geriatr, Sch Med, San Francisco, CA 94121 USA.
[Yaffe, Kristine; Sen, Saunak] San Francisco VA Med Ctr, San Francisco, CA USA.
[Cauley, Jane] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
[Ferrell, Robert] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA.
[Penninx, Brenda] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, EMGO Inst, Amsterdam, Netherlands.
[Harris, Tamara] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
[Li, Rongling] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Ctr Genom & Bioinformat, Memphis, TN 38163 USA.
[Cummings, Steven R.] San Francisco Coordinating Ctr, San Francisco, CA USA.
RP Yaffe, K (reprint author), Univ Calif San Francisco, Dept Psychiat & Neurol, Sch Med, Box 181,4150 Clement St, San Francisco, CA 94121 USA.
EM Kristine.yaffe@uesf.edu
RI Cauley, Jane/N-4836-2015
OI Cauley, Jane/0000-0003-0752-4408
FU NIH, National Institute on Aging; [N01-AG-6-2101]; [N01-AG-6-2103];
[N01-AG6-2106]; [R01-AG021918]
FX Funded by N01-AG-6-2101, N01-AG-6-2103, N01-AG6-2106 and R01-AG021918.
This research was supported in part by the Intramural Research Program
of the NIH, National Institute on Aging.
NR 31
TC 37
Z9 38
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD APR
PY 2009
VL 30
IS 4
BP 607
EP 614
DI 10.1016/j.neurobiolaging.2007.08.003
PG 8
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 424PT
UT WOS:000264579500016
PM 17889406
ER
PT J
AU Rollinson, S
Rizzu, P
Sikkink, S
Baker, M
Halliwell, N
Snowden, J
Traynor, BJ
Ruano, D
Cairns, N
Rohrer, JD
Mead, S
Collinge, J
Rossor, M
Akay, E
Guerreiro, R
Rademakers, R
Morrison, KE
Pastor, P
Alonso, E
Martinez-Lage, P
Graff-Radford, N
Neary, D
Heutink, P
Mann, DMA
Van Swieten, J
Pickering-Brown, SM
AF Rollinson, Sara
Rizzu, Patrizia
Sikkink, Stephen
Baker, Matthew
Halliwell, Nicola
Snowden, Julie
Traynor, Bryan J.
Ruano, Dina
Cairns, Nigel
Rohrer, Jonathan D.
Mead, Simon
Collinge, John
Rossor, Martin
Akay, Ela
Guerreiro, Rita
Rademakers, Rosa
Morrison, Karen E.
Pastor, Pau
Alonso, Elena
Martinez-Lage, Pablo
Graff-Radford, Neil
Neary, David
Heutink, Peter
Mann, David M. A.
Van Swieten, John
Pickering-Brown, Stuart M.
TI Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar
degeneration
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Frontotemporal lobar degeneration; UBAP1; Ubiquitin associated protein
1; TDP-43; Risk factor
ID NEURODEGENERATIVE DISEASE; HAPLOTYPE RECONSTRUCTION; DEMENTIA;
MUTATIONS; PROGRANULIN; LOCUS; TAU; PATHOGENESIS; CONSENSUS; CRITERIA
AB Frontotemporal lobar degeneration (FTLD) is now recognised as a common form of early onset dementia. Up to 40% of patients have a family history of disease demonstrating a large genetic component to its etiology. Linkage to chromosome 9p21 has recently been reported in families with this disorder. We undertook a large scale two-stage linkage disequilibrium mapping approach of this region in the Manchester FTLD cohort. We identified association of ubiquitin associated protein 1 (UBAP1; OR 1.42 95% CI 1.08-1.88, P = 0.013) with FTLD in this cohort and we replicated this finding in an additional two independent cohorts from the Netherlands (OR 1.33 95% CI 1.04-1.69, P = 0.022), the USA (OR 1.4 95% CI 1.02-1.92, P = 0.032) and a forth Spanish cohort approached significant association (OR 1.45 95% CI 0.97-2.17, P = 0.064). However, we failed to replicate in a fifth cohort from London (OR 0.99 95% CI 0.72-1.37, P = 0.989). Quantitative analysis of UBAP1 mRNA extracted from tissue from the Manchester cases demonstrated a significant reduction of expression from the disease-associated haplotype. In addition, we identified a case of familial FTLD that demonstrated colocalisation of UBAP1 and TDP-43 in the neuronal cytoplasmic inclusions in the brain of this individual. Our data for the first time identifies UBAP1 as a genetic risk factor for FTLD and suggests a mechanistic relationship between this protein and TDP-43. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Rollinson, Sara; Sikkink, Stephen; Halliwell, Nicola; Akay, Ela; Pickering-Brown, Stuart M.] Univ Manchester, Fac Human & Med Sci, Manchester M13 9PT, Lancs, England.
[Rizzu, Patrizia; Ruano, Dina; Heutink, Peter] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Sect Med Genom, Amsterdam, Netherlands.
[Baker, Matthew; Rademakers, Rosa; Graff-Radford, Neil] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.
[Snowden, Julie; Neary, David; Mann, David M. A.] Univ Manchester, Ctr Clin Neurosci, Greater Manchester Neurosci Ctr, Hope Hosp, Salford M6 8HD, Lancs, England.
[Traynor, Bryan J.; Guerreiro, Rita] NIA, Neurogenet Lab, Neurogenet Branch, Natl Inst Neurol Disorders & Stroke,NIH, Bethesda, MD 20892 USA.
[Cairns, Nigel] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA.
[Cairns, Nigel] Washington Univ, Sch Med, Rush Alzheimers Dis Ctr, St Louis, MO USA.
[Rohrer, Jonathan D.; Rossor, Martin] Dementia Res Ctr, Inst Neurol, London WC1N 3BG, England.
[Mead, Simon; Collinge, John] UCL Inst Neurol, MRC Prion Unit, Dept Neurodegenerat Dis, London WC1N 3BG, England.
[Guerreiro, Rita] Univ Coimbra, Ctr Neurosci & Cell Biol, Coimbra, Portugal.
[Morrison, Karen E.] Univ Birmingham, Sch Med, Dept Clin Neurosci, Div Neurosci, Birmingham B15 2TT, W Midlands, England.
[Morrison, Karen E.] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England.
[Pastor, Pau; Alonso, Elena] Ctr Appl Med Res CIMA, Neurogenet Lab, Div Neurosci, Pamplona, Spain.
[Pastor, Pau; Alonso, Elena] Univ Navarra, Sch Med, Dept Neurol, E-31080 Pamplona, Spain.
[Martinez-Lage, Pablo] ACE, Barcelona, Spain.
[Van Swieten, John] Erasmus MC, Rotterdam, Netherlands.
RP Pickering-Brown, SM (reprint author), Univ Manchester, Fac Human & Med Sci, Oxford Rd, Manchester M13 9PT, Lancs, England.
EM SPB@Manchester.ac.uk
RI Traynor, Bryan/G-5690-2010; Pickering-Brown, Stuart/D-4008-2009; Cairns,
Nigel/A-1267-2010; Mead, Simon/E-9414-2011; Pastor, Pau/C-9834-2009;
Guerreiro, Rita/A-1327-2011
OI Rohrer, Jonathan/0000-0002-6155-8417; Pickering-Brown,
Stuart/0000-0003-1561-6054; Snowden, Julie/0000-0002-3976-4310; van
Swieten, John /0000-0001-6278-6844; Mead, Simon/0000-0002-4326-1468;
Pastor, Pau/0000-0002-7493-8777;
FU Medical Research Council; Alzheimers Research Trust; NIH, National
Institute on Aging [Z01-AG000949-02]; National Institute of Neurological
Disorders and Stroke; Fundacao para a Ciencia e Tecnologia, Portugal
[SFRH/BD/27442/2006]; NIH [P50 AG16574]; Pacific Alzheimer's Disease
Research Foundation [C06-01]; Government of Navarra
FX SPB and DMAM received funding from the Medical Research Council and the
Alzheimers Research Trust to support this work. This research was also
supported (in part) by the Intramural Research Program of the NIH,
National Institute on Aging (Z01-AG000949-02) and National Institute of
Neurological Disorders and Stroke. RG received support from rant
#SFRH/BD/27442/2006 from Fundacao para a Ciencia e Tecnologia, Portugal.
This work was also supported by NIH grants P50 AG16574 (NG-R and RR) and
the Pacific Alzheimer's Disease Research Foundation grant #C06-01 (RR).
This work was supported by grants from the Government of Navarra
("Ayudas para la Realizacion de Proyectos de Investigacion" 2006-2007)
to PP.
NR 27
TC 24
Z9 24
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD APR
PY 2009
VL 30
IS 4
BP 656
EP 665
DI 10.1016/j.neurobiolaging.2009.01.009
PG 10
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 424PT
UT WOS:000264579500021
PM 19217189
ER
PT J
AU Tang, H
Pavel, J
Saavedra, JM
Brimijoin, S
AF Tang, Hui
Pavel, Jaroslav
Saavedra, Juan M.
Brimijoin, Stephen
TI Type-1 angiotensin receptors are expressed and transported in motor and
sensory axons of rat sciatic nerves
SO NEUROPEPTIDES
LA English
DT Article
DE Neuropeptide receptors; Axonal transport; Nerve ligation; Retrograde
fluorescence tracing; Dorsal root ganglia; Spinal cord ventral horn;
Choline acetyltransferase; Calcitonin-gene-related peptide
ID GENE-RELATED PEPTIDE; DORSAL-ROOT GANGLIA; GROWTH-FACTOR; ANTEROGRADE
TRANSPORT; PERIPHERAL-NERVE; PASTE STANDARDS; UP-REGULATION;
SPINAL-CORD; SYSTEM; BRAIN
AB Angiotensin II (Ang II) and its type-l receptor (AT(1)) occur in neurons at multiple locations within the organism, but the basic biology of the receptor in the nervous system remains incompletely understood. We previously observed abundant AT(1)-like binding sites and intense expression of AT(1) immunoreactivity in perikarya of the dorsal root ganglion and ventral horn of the rat spinal cord. We have now examined the receptor in rat sciatic nerve, including the dynamics of its axonal transport. Ligand-binding autoradiography of resting nerve showed "hot spots,, of (125)I-Ang II binding that could be specifically blocked by the AT(1) antagonist, losartan. Immunohistochemistry with an AT(1)-antibody validated by Western blots also showed patches of AT(1)-reactivity in nerve. These patches were localized around large myelinated axons with faint immunoreactivity in their lumens. Sixteen hours after nerve ligation there was no change in the patches or hot spots, but luminal AT(1)-reactivity increased dramatically in a narrow zone immediately above the ligature. With double ligation there was a pronounced accumulation of AT(1) immunoreactivity proximal to the upstream ligature and a very slight accumulation distal to the second ligature. This asymmetric pattern of accumulation, confirmed by quantitative receptor binding auto radiography, probably reflected axonal transport rather than local production of receptor. Retrograde tracing and stereological analysis to determine the source of transported AT(1) indicated that many AT(1)-positive fibers arise in the ventral horn, and a larger number arise in dorsal root ganglia. A corresponding result was obtained with double-label immunohistochemistry of ligated nerve, which showed AT(1) accumulations in both motor and sensory fibers. We conclude that somatic sensory and motor neurons of the rat export substantial quantities of AT(1) into axons, which transport them to the periphery. The physiologic implications of this finding require further investigation. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Tang, Hui; Brimijoin, Stephen] Mayo Clin, Dept Mol Pharmacol, Rochester, MN 55905 USA.
[Pavel, Jaroslav; Saavedra, Juan M.] NIMH, Pharmacol Sect, Bethesda, MD 20892 USA.
RP Brimijoin, S (reprint author), Mayo Clin, Dept Mol Pharmacol, 200 1st St SW, Rochester, MN 55905 USA.
EM Brimijoin@mayo.edu
FU Mayo Distinguished Investigator Award; Division of Intramural Research
Programs; National Institutes of Mental Health
FX Sources of support: Mayo Distinguished Investigator Award (to S.B.) and
Division of Intramural Research Programs, National Institutes of Mental
Health (to J.S.).
NR 39
TC 5
Z9 5
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 81
EP 92
DI 10.1016/j.npep.2009.01.001
PG 12
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700004
PM 19230969
ER
PT J
AU Catt, KJ
Hu, L
Gustofson, H
Feng, H
Leung, PK
Mores, N
AF Catt, Kevin J.
Hu, L.
Gustofson, H.
Feng, H.
Leung, P. K.
Mores, N.
TI REGULATORY FUNCTIONS OF ESTROGEN RECEPTOR-alpha and -beta SUBTYPES
EXPRESSED IN HYPOTHALAMIC GnRH NEURONS
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Catt, Kevin J.; Hu, L.; Gustofson, H.; Feng, H.; Leung, P. K.; Mores, N.] NICHD, LZ Krsmanov Endocrinol & Reprod Res Branch, PDGEN, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 151
EP 151
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700016
ER
PT J
AU Dufau, ML
Zhang, Y
Liao, MJ
AF Dufau, Maria L.
Zhang, Ying
Liao, Mingjuan
TI SIGNALING EVENTS IN DEREPRESSION OF LH RECEPTOR TRANSCRIPTION
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Dufau, Maria L.; Zhang, Ying; Liao, Mingjuan] EKS NICHD, Sect Mol Endocrinol, ERRB, PDE GEN,NIH, Bethesda, MD 20892 USA.
EM dufaum@mail.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 152
EP 152
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700018
ER
PT J
AU Bailey, KR
Freeman, AK
Chadman, KK
Crawley, JN
AF Bailey, Kathleen R.
Freeman, Anike K.
Chadman, Kathryn K.
Crawley, Jacqueline N.
TI BEHAVIORAL PHENOTYPES OF GALR1/GALR2 DOUBLE KNOCKOUT MICE: RELEVANCE FOR
ANXIETY- AND DEPRESSION-RELATED BEHAVIORS
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 Susquehanna Univ, Selinsgrove, PA 17870 USA.
NIMH, Lab Behav Neurosci, NIH, Bethesda, MD 20892 USA.
EM baileyk@susqu.edu
NR 0
TC 0
Z9 0
U1 1
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 153
EP 154
PG 2
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700021
ER
PT J
AU Loh, YP
Woronowicz, A
Murthy, S
Cawley, NX
Koshimizu, H
Lee, TK
Poon, RT
AF Loh, Y. Peng
Woronowicz, Alicja
Murthy, Saravana
Cawley, Niamh X.
Koshimizu, Hsatsugu
Lee, Terence K.
Poon, Ronnie T.
TI CARBOXYPEPTIDASE E IN NEUROPROTECTION AND CANCER
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Loh, Y. Peng; Woronowicz, Alicja; Murthy, Saravana; Cawley, Niamh X.; Koshimizu, Hsatsugu] NICHD, Cellular Neurobiol Sect, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA.
[Lee, Terence K.; Poon, Ronnie T.] Univ Hong Kong, Dept Surg, Pokfulam, Hong Kong, Peoples R China.
EM lohp@mail.nih.gov
RI Koshimizu, Hisatsugu/G-5536-2010
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 156
EP 156
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700025
ER
PT J
AU Eiden, LE
AF Eiden, Lee E.
TI MICROARRAY-DIRECTED GENE DISCOVERY FOR NEUROPEPTIDE SIGNALING IN STRESS
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Eiden, Lee E.] NIMH, Mol Neurosci Sect, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
EM eidenl@mail.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 158
EP 159
PG 2
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700030
ER
PT J
AU Balla, T
Szentpetery, Z
Kim, YJ
Korzeniowski, M
Varnai, P
AF Balla, Tamas
Szentpetery, Zsofia
Kim, Yeu Ju
Korzeniowski, Marek
Varnai, Peter
TI STUDYING INOSITOL LIPID-BASED SIGNALING WITH NOVEL MOLECULAR TOOLS
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Balla, Tamas; Szentpetery, Zsofia; Kim, Yeu Ju; Korzeniowski, Marek; Varnai, Peter] NICHD, Sect Mol Signal Transduct, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA.
EM ballat@mail.nih.gov
RI Korzeniowski, Marek/G-7214-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 159
EP 159
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700031
ER
PT J
AU Stojilkovic, SS
Yan, Z
Zemkova, H
Li, S
Tomic, M
AF Stojilkovic, Stanko S.
Yan, Zonghe
Zemkova, Hana
Li, Shuo
Tomic, Melanija
TI SIGNALING BY PURINERGIC P2X RECEPTOR CHANNELS
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Stojilkovic, Stanko S.; Yan, Zonghe; Zemkova, Hana; Li, Shuo; Tomic, Melanija] NICHD, Sect Cellular Signaling, PDN, NIH, Bethesda, MD 20892 USA.
EM stojilks@mail.nih.gov
RI Tomic, Melanija/C-3371-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 162
EP 163
PG 2
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700037
ER
PT J
AU Aguilera, G
Liu, Y
AF Aguilera, Greti
Liu, Ying
TI SIGNALING EVENTS REGULATING CORTICOTROPHIN RELEASING HORMONE EXPRESSION
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Aguilera, Greti; Liu, Ying] NICHHD, Sect Endocrine Physiol, PEDGEN, NIH, Bethesda, MD 20892 USA.
EM aguilerg@ccl.nichd.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 169
EP 170
PG 2
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700051
ER
PT J
AU Eiden, MV
AF Eiden, M. V.
TI RETROVIRAL VECTORS AND TRANSLATIONAL APPROACHES TO DISEASES OF THE
NERVOUS SYSTEM
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Eiden, M. V.] NIMH, Sect Mol Virol, NIH, Bethesda, MD 20892 USA.
EM eidenm@mail.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 171
EP 171
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700055
ER
PT J
AU Gershengorn, MC
AF Gershengorn, Marvin C.
TI LOW MOLECULAR WEIGHT LIGANDS FOR THE HUMAN THYROTROPIN RECEPTOR WITH
THERAPEUTIC POTENTIAL FOR HYPERTHYROIDISM AND THYROID CANCER
SO NEUROPEPTIDES
LA English
DT Meeting Abstract
CT Summer Neuropeptide Conference/5th International Symposium on Signal
Transduction in Health and Diseaase (STADY V)
CY OCT 22-24, 2008
CL Tel Aviv, ISRAEL
C1 [Gershengorn, Marvin C.] NIDDK, Lab Biol Modeling, NIH, Bethesda, MD 20892 USA.
EM MarvinG@intra.niddk.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2009
VL 43
IS 2
BP 171
EP 171
PG 1
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 437XR
UT WOS:000265520700054
ER
EF