FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Takayama, Y
Clore, GM
AF Takayama, Yuki
Clore, G. Marius
TI Interplay between Minor and Major Groove-binding Transcription Factors
Sox2 and Oct1 in Translocation on DNA Studied by Paramagnetic and
Diamagnetic NMR
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID MOLECULAR-STRUCTURE DETERMINATION; PROTEIN-PROTEIN ASSOCIATION;
RELAXATION ENHANCEMENT; POU DOMAIN; EXCHANGE SPECTROSCOPY; COGNATE
SITES; XPLOR-NIH; COMPLEXES; MACROMOLECULES; VISUALIZATION
AB The pathways whereby Sox2 scans DNA to locate its specific binding site are investigated by NMR in specific and nonspecific Sox2.DNA complexes and in a specific ternary complex with Oct1 on the Hoxb1 regulatory element. Direct transfer of Sox2 between nonspecific sites on different DNA molecules occurs without dissociation into free solution at a rate of similar to 10(6) M-1 s(-1), whereas one-dimensional sliding proceeds with a diffusion constant of >= 0.1 mu m(2).s(-1). Translocation of Sox2 from one specific DNA site to another occurs via jumping, involving complete dissociation into free solution (k(d)similar to 5-6 s(-1)) followed by reassociation (k(a)similar to 5 x 10(8) M-1 s(-1)). In the presence of Oct1 bound to an adjacent specific site, k(d) is reduced by more than 10-fold. Paramagnetic relaxation measurements, however, demonstrate that sparsely populated (<1%), transient states involving nonspecifically bound Sox2 in rapid exchange with specifically bound Sox2 are sampled in both binary Sox2.DNA- and ternary Oct1.Sox2.Hoxb1-DNA-specific complexes. Moreover, Sox2 modulates the mechanism of translocation of Oct1. Both Sox2 and the Oct1 POUHD domain are transiently released from the specific ternary complex by sliding to an adjacent nonspecific site, followed by direct transfer to another DNA molecule, whereas the Oct1 POUS domain is fixed to its specific site through direct interactions with Sox2. Intermolecular translocation of POUHD results in the formation of a bridged intermediate spanning two DNA molecules, enhancing the probability of complete intermolecular translocation of Oct1. By way of contrast, in the specific Oct1.DNA binary complex, POUS undergoes direct intermolecular translocation, whereas POUHD scans the DNA by sliding.
C1 [Takayama, Yuki; Clore, G. Marius] NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA.
RP Clore, GM (reprint author), NIDDK, Chem Phys Lab, NIH, Bldg 5, Bethesda, MD 20892 USA.
EM mariusc@intra.niddk.nih.gov
RI Clore, G. Marius/A-3511-2008
OI Clore, G. Marius/0000-0003-3809-1027
FU National Institutes of Health, NIDDK; Office of the Director of the
National Institutes of Health; Japan Society for the Promotion of
Science
FX This work was supported, in whole or in part, by the National Institutes
of Health, NIDDK, Intramural Program and by the AIDS Targeted Antiviral
Program of the Office of the Director of the National Institutes of
Health (to G. M. C.).; Supported by a Japan Society for the Promotion of
Science Research Fellowship for Japanese Biomedical and Behavioral
Researchers at the National Institutes of Health.
NR 37
TC 15
Z9 15
U1 1
U2 8
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 14349
EP 14363
DI 10.1074/jbc.M112.352864
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200004
PM 22396547
ER
PT J
AU Wickner, RB
AF Wickner, Reed B.
TI Discovering Protein-based Inheritance through Yeast Genetics
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID DOUBLE-STRANDED-RNA; BETA-SHEET STRUCTURE; RIBOSOMAL-SUBUNIT BIOGENESIS;
TERMINATION FACTOR ERF3; PRION-INDUCING DOMAIN; L-A VIRUS;
SACCHAROMYCES-CEREVISIAE; MESSENGER-RNA; IN-VITRO; ESCHERICHIA-COLI
C1 NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA.
RP Wickner, RB (reprint author), NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA.
EM wickner@helix.nih.gov
NR 128
TC 4
Z9 4
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 14432
EP 14442
DI 10.1074/jbc.X112.355636
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200011
PM 22396539
ER
PT J
AU Zanou, N
Schakman, O
Louis, P
Ruegg, UT
Dietrich, A
Birnbaumer, L
Gailly, P
AF Zanou, Nadege
Schakman, Olivier
Louis, Pierre
Ruegg, Urs T.
Dietrich, Alexander
Birnbaumer, Lutz
Gailly, Philippe
TI Trpc1 Ion Channel Modulates Phosphatidylinositol 3-Kinase/Akt Pathway
during Myoblast Differentiation and Muscle Regeneration
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID GROWTH-FACTOR-I; CELL-CYCLE ARREST; HELIX-LOOP-HELIX; SKELETAL-MUSCLE;
MYOGENIN EXPRESSION; MYOCYTE MATURATION; MOUSE EMBRYO; IGF-I; MYOD;
ACTIVATION
AB We previously showed in vitro that calcium entry through Trpc1 ion channels regulates myoblast migration and differentiation. In the present work, we used primary cell cultures and isolated muscles from Trpc1(-/-) and Trpc1(+/+) murine model to investigate the role of Trpc1 in myoblast differentiation and in muscle regeneration. In these models, we studied regeneration consecutive to cardiotoxin-induced muscle injury and observed a significant hypotrophy and a delayed regeneration in Trpc1(-/-) muscles consisting in smaller fiber size and increased proportion of centrally nucleated fibers. This was accompanied by a decreased expression of myogenic factors such as MyoD, Myf5, and myogenin and of one of their targets, the developmental MHC (MHCd). Consequently, muscle tension was systematically lower in muscles from Trpc1(-/-) mice. Importantly, the PI3K/Akt/mTOR/p70S6K pathway, which plays a crucial role in muscle growth and regeneration, was down-regulated in regenerating Trpc1(-/-) muscles. Indeed, phosphorylation of both Akt and p70S6K proteins was decreased as well as the activation of PI3K, the main upstream regulator of the Akt. This effect was independent of insulin-like growth factor expression. Akt phosphorylation also was reduced in Trpc1(-/-) primary myoblasts and in control myoblasts differentiated in the absence of extracellular Ca2+ or pretreated with EGTA-AM or wortmannin, suggesting that the entry of Ca2+ through Trpc1 channels enhanced the activity of PI3K. Our results emphasize the involvement of Trpc1 channels in skeletal muscle development in vitro and in vivo, and identify a Ca2+-dependent activation of the PI3K/Akt/mTOR/p70S6K pathway during myoblast differentiation and muscle regeneration.
C1 [Zanou, Nadege; Schakman, Olivier; Louis, Pierre; Gailly, Philippe] Catholic Univ Louvain, Lab Cell Physiol, Inst Neurosci, B-1200 Brussels, Belgium.
[Ruegg, Urs T.] Univ Geneva, Geneva Lausanne Sch Pharmaceut Sci, Pharmacol Lab, CH-1211 Geneva 4, Switzerland.
[Dietrich, Alexander] Univ Munich, Walther Straub Inst Pharmakol & Toxikol, D-80336 Munich, Germany.
[Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Neurobiol Lab, Res Triangle Pk, NC 27709 USA.
RP Zanou, N (reprint author), Catholic Univ Louvain, Lab Cell Physiol, Inst Neurosci, 55-40 Av Hippocrate, B-1200 Brussels, Belgium.
EM nadege.zanou@uclouvain.be; philippe.gailly@uclouvain.be
RI Dietrich, Alexander/G-8619-2013;
OI Dietrich, Alexander/0000-0002-1168-8707; RUEGG, Urs/0000-0001-6078-8280
FU National Institutes of Health [Z01-101684]; Association francaise contre
les myopathies; Association Belge contre les Maladies Neuro-musculaires;
General Direction of Scientific Research of the French Community of
Belgium [ARC 10/15-029]
FX This work was supported, in whole or in part, by the Intramural Research
Program of the National Institutes of Health Z01-101684 (to L. B.). This
work was also supported by the "Association francaise contre les
myopathies", the "Association Belge contre les Maladies
Neuro-musculaires", by Grant ARC 10/15-029 from the General Direction of
Scientific Research of the French Community of Belgium.
NR 50
TC 21
Z9 21
U1 0
U2 15
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 14524
EP 14534
DI 10.1074/jbc.M112.341784
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200019
PM 22399301
ER
PT J
AU Brzeska, H
Guag, J
Preston, GM
Titus, MA
Korn, ED
AF Brzeska, Hanna
Guag, Jake
Preston, G. Michael
Titus, Margaret A.
Korn, Edward D.
TI Molecular Basis of Dynamic Relocalization of Dictyostelium Myosin IB
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PLECKSTRIN HOMOLOGY DOMAIN; PLASMA-MEMBRANE; IN-VIVO; FUSION PROTEINS;
ARP2/3 COMPLEX; CELL-MIGRATION; LIVING CELLS; SH3 DOMAIN; HELA-CELLS;
TEDS RULE
AB Class I myosins have a single heavy chain comprising an N-terminal motor domain with actin-activated ATPase activity and a C-terminal globular tail with a basic region that binds to acidic phospholipids. These myosins contribute to the formation of actin-rich protrusions such as pseudopodia, but regulation of the dynamic localization to these structures is not understood. Previously, we found that Acanthamoeba myosin IC binds to acidic phospholipids in vitro through a short sequence of basic and hydrophobic amino acids, BH site, based on the charge density of the phospholipids. The tail of Dictyostelium myosin IB (DMIB) also contains a BH site. We now report that the BH site is essential for DMIB binding to the plasma membrane and describe the molecular basis of the dynamic relocalization of DMIB in live cells. Endogenous DMIB is localized uniformly on the plasma membrane of resting cells, at active protrusions and cell-cell contacts of randomly moving cells, and at the front of motile polarized cells. The BH site is required for association of DMIB with the plasma membrane at all stages where it colocalizes with phosphoinositide bisphosphate/phosphoinositide trisphosphate (PIP2/PIP3). The charge-based specificity of the BH site allows for in vivo specificity of DMIB for PIP2/PIP3 similar to the PH domain-based specificity of other class I myosins. However, DMIB-head is required for relocalization of DMIB to the front of migrating cells. Motor activity is not essential, but the actin binding site in the head is important. Thus, dynamic relocalization of DMIB is determined principally by the local PIP2/PIP3 concentration in the plasma membrane and cytoplasmic F-actin.
C1 [Brzeska, Hanna; Guag, Jake; Preston, G. Michael; Korn, Edward D.] NHLBI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA.
[Titus, Margaret A.] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA.
RP Brzeska, H (reprint author), NHLBI, Cell Biol Lab, NIH, 9000 Rockville Pike,Bldg 50,Rm 2515, Bethesda, MD 20892 USA.
EM brzeskah@mail.nih.gov
FU National Institutes of Health [GM046486]; NHLBI Intramural Research,
National Institutes of Health
FX This work was supported, in whole or in part, by National Institutes of
Health Grant GM046486 (to M. A. T.). This work was also supported by the
NHLBI Intramural Research Program, National Institutes of Health.
NR 85
TC 9
Z9 9
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 14923
EP 14936
DI 10.1074/jbc.M111.318667
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200055
PM 22367211
ER
PT J
AU Yu, X
Luo, Y
Dinkel, P
Zheng, J
Wei, GH
Margittai, M
Nussinov, R
Ma, BY
AF Yu, Xiang
Luo, Yin
Dinkel, Paul
Zheng, Jie
Wei, Guanghong
Margittai, Martin
Nussinov, Ruth
Ma, Buyong
TI Cross-seeding and Conformational Selection between Three- and
Four-repeat Human Tau Proteins
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PAIRED HELICAL FILAMENTS; MOLECULAR-DYNAMICS SIMULATIONS;
BETA-STRUCTURE; ALZHEIMERS-DISEASE; NEURODEGENERATIVE-DISEASES;
IN-VITRO; AGGREGATION; SHEET; ISOFORMS; PEPTIDE
AB In Alzheimer's disease and frontotemporal dementias, the microtubule-associated protein Tau forms intracellular paired helical filaments. The filaments can form not only by the full-length human Tau protein, but also by the three repeated (K19) or four repeated (K18) Tau segments. However, of interest, experimentally, K19 can seed K18, but not vice versa. To obtain insight into the cross-seeding between K18 and K19 aggregates, here, K18 and K19 octamers with repeat 3 (R3) in U-shaped, L-shaped, and long straight line-shaped (SL-shape) conformations are assembled into different structures. The simulation results show that K18-8/K19-8 (K18 and K19 assemblies number 8) with R3 in an L shape and K18-9/K19-9 with R3 in an SL shape are highly populated and present the highest structural similarity among all simulated K18 and K19 octamers, suggesting that similar folding of K18/K19 may serve as structural core for the K18-K19 co-assembled heterogeneous filament. We demonstrate that formation of stable R2 and R3 conformations is the critical step for K18 aggregation, and R3 is critical for K19 fibrillization. The different core units in K18 and K19 may create a cross-seeding barrier for the K18 seed to trigger K19 fibril growth because R2 is not available for K19. Our study provides insights into cross-seeding involving heterogeneous structures. The polymorphic nature of protein aggregation could be magnified in the cross-seeding process. If the seeding conformations lead to too much divergence in the energy landscape, it could impede fibril formation. Such an effect could also contribute to the asymmetric barrier between K18 and K19.
C1 [Yu, Xiang; Luo, Yin; Zheng, Jie] Univ Akron, Dept Chem & Biomol Engn, Akron, OH 44325 USA.
[Luo, Yin; Wei, Guanghong] Fudan Univ, State Key Lab Surface Phys, Key Lab Computat Phys Sci, Minist Educ, Shanghai 200433, Peoples R China.
[Luo, Yin; Wei, Guanghong] Fudan Univ, Dept Phys, Shanghai 200433, Peoples R China.
[Dinkel, Paul; Margittai, Martin] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA.
[Nussinov, Ruth; Ma, Buyong] NCI, Basic Res Program, SAIC Frederick Inc, Ctr Canc Res Nanobiol Program, Frederick, MD 21702 USA.
[Nussinov, Ruth] Tel Aviv Univ, Dept Human Genet & Mol Med, Sackler Inst Mol Med, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
RP Zheng, J (reprint author), Univ Akron, Dept Chem & Biomol Engn, Akron, OH 44325 USA.
EM zhengj@uakron.edu; ghwei@fudan.edu.cn; ruthnu@helix.nih.gov
RI Ma, Buyong/F-9491-2011; Zheng, Jie/B-5057-2013; Margittai,
Martin/D-5039-2014; Yu, Xiang/A-9765-2012
OI Ma, Buyong/0000-0002-7383-719X; Zheng, Jie/0000-0003-1547-3612;
Margittai, Martin/0000-0003-1903-5927; Yu, Xiang/0000-0002-0486-1110
FU National Institutes of Health [R01NS076619]; National Cancer Institute
[HHSN261200800001E]; National Cancer Institute Center for Cancer
Research, National Science Foundation [CBET-0952624]; National Natural
Science Foundation of China [11074047]; Research Fund for the Doctoral
Program of Higher Education of China [RFDP-20100071110006]
FX This work was supported, in whole or in part, by National Institutes of
Health Grant R01NS076619 (to M. M.). This work was also supported by
National Cancer Institute Contract HHSN261200800001E, the intramural
research program of the National Cancer Institute Center for Cancer
Research, National Science Foundation CAREER Award CBET-0952624 (to J.
Z.), a 3M nontenured faculty award (to J. Z.), National Natural Science
Foundation of China Grant 11074047 (to G. W.), and Research Fund for the
Doctoral Program of Higher Education of China Grant RFDP-20100071110006
(to G. W.).
NR 42
TC 28
Z9 28
U1 1
U2 22
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 14950
EP 14959
DI 10.1074/jbc.M112.340794
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200057
PM 22393063
ER
PT J
AU Dogo-Isonagie, C
Lam, S
Gustchina, E
Acharya, P
Yang, YP
Shahzad-ul-Hussan, S
Clore, GM
Kwong, PD
Bewley, CA
AF Dogo-Isonagie, Cajetan
Lam, Son
Gustchina, Elena
Acharya, Priyamvada
Yang, Yongping
Shahzad-ul-Hussan, Syed
Clore, G. Marius
Kwong, Peter D.
Bewley, Carole A.
TI Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5
(CCR5) Inhibit Diverse Strains of HIV-1
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; PROTEIN-COUPLED RECEPTOR; ENVELOPE
GLYCOPROTEIN; CORECEPTOR ACTIVITY; GP120 BINDING; N-TERMINUS;
MONOCLONAL-ANTIBODIES; CRYSTAL-STRUCTURE; ENTRY INHIBITORS;
MEMBRANE-FUSION
AB To initiate HIV entry, the HIV envelope protein gp120 must engage its primary receptor CD4 and a coreceptor CCR5 or CXCR4. In the absence of a high resolution structure of a gp120-coreceptor complex, biochemical studies of CCR5 have revealed the importance of its N terminus and second extracellular loop (ECL2) in binding gp120 and mediating viral entry. Using a panel of synthetic CCR5 ECL2-derived peptides, we show that the C-terminal portion of ECL2 (2C, comprising amino acids Cys-178 to Lys-191) inhibit HIV-1 entry of both CCR5- and CXCR4-using isolates at low micromolar concentrations. In functional viral assays, these peptides inhibited HIV-1 entry in a CD4-independent manner. Neutralization assays designed to measure the effects of CCR5 ECL2 peptides when combined with either with the small molecule CD4 mimetic NBD-556, soluble CD4, or the CCR5 N terminus showed additive inhibition for each, indicating that ECL2 binds gp120 at a site distinct from that of N terminus and acts independently of CD4. Using saturation transfer difference NMR, we determined the region of CCR5 ECL2 used for binding gp120, showed that it can bind to gp120 from both R5 and X4 isolates, and demonstrated that the peptide interacts with a CD4-gp120 complex in a similar manner as to gp120 alone. As the CCR5 N terminus-gp120 interactions are dependent on CD4 activation, our data suggest that gp120 has separate binding sites for the CCR5 N terminus and ECL2, the ECL2 binding site is present prior to CD4 engagement, and it is conserved across CCR5-and CXCR4-using strains. These peptides may serve as a starting point for the design of inhibitors with broad spectrum anti-HIV activity.
C1 [Dogo-Isonagie, Cajetan; Lam, Son; Shahzad-ul-Hussan, Syed; Bewley, Carole A.] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA.
[Gustchina, Elena; Clore, G. Marius] NIDDK, Chem Phys Lab, Bethesda, MD 20892 USA.
[Acharya, Priyamvada; Yang, Yongping; Shahzad-ul-Hussan, Syed; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
RP Bewley, CA (reprint author), NIDDK, Bioorgan Chem Lab, 8 Ctr Dr, Bethesda, MD 20892 USA.
EM caroleb@mail.nih.gov
RI Clore, G. Marius/A-3511-2008
OI Clore, G. Marius/0000-0003-3809-1027
FU National Institutes of Health (NIDDK and NIAID); Office of the Director,
National Institutes of Health; Intramural AIDS Research Fellowship
FX This work was supported by the Intramural Research Program, National
Institutes of Health (NIDDK and NIAID), and the Intramural AIDS Targeted
Antiviral Program, Office of the Director, National Institutes of Health
(to C. A. B. and G. M. C.).; Recipient of an Intramural AIDS Research
Fellowship award.
NR 56
TC 12
Z9 12
U1 2
U2 16
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 27
PY 2012
VL 287
IS 18
BP 15076
EP 15086
DI 10.1074/jbc.M111.332361
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941XU
UT WOS:000304003200069
PM 22403408
ER
PT J
AU Chen, CY
Chi, YH
Mutalif, RA
Starost, MF
Myers, TG
Anderson, SA
Stewart, CL
Jeang, KT
AF Chen, Chia-Yen
Chi, Ya-Hui
Mutalif, Rafidah Abdul
Starost, Matthew F.
Myers, Timothy G.
Anderson, Stasia A.
Stewart, Colin L.
Jeang, Kuan-Teh
TI Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in
Progeric and Dystrophic Laminopathies
SO CELL
LA English
DT Article
ID HUTCHINSON-GILFORD-PROGERIA; ENCODING LAMIN A/C; GIRDLE
MUSCULAR-DYSTROPHY; CHARCOT-MARIE-TOOTH; A-TYPE LAMINS;
ALZHEIMERS-DISEASE; MISSENSE MUTATION; MICE; GENE; MIGRATION
AB Human LMNA gene mutations result in laminopathies that include Emery-Dreifuss muscular dystrophy (AD-EDMD) and Hutchinson-Gilford progeria, the premature aging syndrome (HGPS). The Lmna null (Lmna(-/-)) and progeroid Lmna Delta 9 mutant mice are models for AD-EDMD and HGPS, respectively. Both animals develop severe tissue pathologies with abbreviated life spans. Like HGPS cells, Lmna(-/-) and Lmna Delta 9 fibroblasts have typically misshapen nuclei. Unexpectedly, Lmna(-/-) or Lmna Delta 9 mice that are also deficient for the inner nuclear membrane protein Sun1 show markedly reduced tissue pathologies and enhanced longevity. Concordantly, reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from HGPS patients corrected nuclear defects and cellular senescence. Collectively, these findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), Lmna Delta 9, and HGPS disorders.
C1 [Chi, Ya-Hui] Natl Hlth Res Inst, Inst Cellular & Syst Med, Zhunan 35053, Taiwan.
[Chen, Chia-Yen; Jeang, Kuan-Teh] NIAID, Natl Inst Hlth, Bethesda, MD 20892 USA.
[Starost, Matthew F.] Natl Inst Hlth, Div Vet Resources, Bethesda, MD 20892 USA.
[Myers, Timothy G.] NIAID, Genom Technol Sect, Natl Inst Hlth, Bethesda, MD 20892 USA.
[Anderson, Stasia A.] Natl Heart Lung & Blood Inst Anim MRI Core, Natl Inst Hlth, Bethesda, MD 20892 USA.
[Mutalif, Rafidah Abdul; Stewart, Colin L.] Inst Med Biol, Singapore 138648, Singapore.
[Stewart, Colin L.] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore.
RP Chi, YH (reprint author), Natl Hlth Res Inst, Inst Cellular & Syst Med, Zhunan 35053, Taiwan.
EM ychi@nhri.org.tw; kjeang@nih.gov
RI Jeang, Kuan-Teh/A-2424-2008; Chi, Ya-Hui/B-1080-2010
FU NIAID; IATAP, NIAID; NHRI, Taiwan [NHRI 99A1-CSPP11-014]; NSC, Taiwan
[NSC 98-2320-B-400-009-MY3]; Singapore Biomedical Research Council;
Agency for Science, Technology and Research (AstarSTAR)
FX Work was supported by NIAID intramural funds, the IATAP, NIAID contract
to SoBran, Inc., the NHRI, Taiwan (NHRI 99A1-CSPP11-014), and NSC,
Taiwan (NSC 98-2320-B-400-009-MY3), and the Singapore Biomedical
Research Council and Agency for Science, Technology and Research
(AstarSTAR). We thank S.-Y. Chuang, E. Miyagi, J.M. Ward, L.
I. Cheng, Z.J. Chen, J. Kabat, S. Becker, S. Bradford, Q. Su, and D.
Donahue for assistance; and W. Leonard, J. Hanover, A. Dayton, Y.B. Shi,
and D. Camerini-Otero for reading the manuscript.
NR 57
TC 59
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U1 1
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD APR 27
PY 2012
VL 149
IS 3
BP 565
EP 577
DI 10.1016/j.cell.2012.01.059
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 934KN
UT WOS:000303443100009
PM 22541428
ER
PT J
AU Talkowski, ME
Rosenfeld, JA
Blumenthal, I
Pillalamarri, V
Chiang, C
Heilbut, A
Ernst, C
Hanscom, C
Rossin, E
Lindgren, AM
Pereira, S
Ruderfer, D
Kirby, A
Ripke, S
Harris, DJ
Lee, JH
Ha, K
Kim, HG
Solomon, BD
Gropman, AL
Lucente, D
Sims, K
Ohsumi, TK
Borowsky, ML
Loranger, S
Quade, B
Lage, K
Miles, J
Wu, BL
Shen, YP
Neale, B
Shaffer, LG
Daly, MJ
Morton, CC
Gusella, JF
AF Talkowski, Michael E.
Rosenfeld, Jill A.
Blumenthal, Ian
Pillalamarri, Vamsee
Chiang, Colby
Heilbut, Adrian
Ernst, Carl
Hanscom, Carrie
Rossin, Elizabeth
Lindgren, Amelia M.
Pereira, Shahrin
Ruderfer, Douglas
Kirby, Andrew
Ripke, Stephan
Harris, David J.
Lee, Ji-Hyun
Ha, Kyungsoo
Kim, Hyung-Goo
Solomon, Benjamin D.
Gropman, Andrea L.
Lucente, Diane
Sims, Katherine
Ohsumi, Toshiro K.
Borowsky, Mark L.
Loranger, Stephanie
Quade, Bradley
Lage, Kasper
Miles, Judith
Wu, Bai-Lin
Shen, Yiping
Neale, Benjamin
Shaffer, Lisa G.
Daly, Mark J.
Morton, Cynthia C.
Gusella, James F.
TI Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci
that Confer Risk across Diagnostic Boundaries
SO CELL
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; PITT-HOPKINS-SYNDROME; CHROMATIN REMODELING
FACTOR; GENOME-WIDE ASSOCIATION; MICRODELETION SYNDROME; DEVELOPMENTAL
DELAY; SUSCEPTIBILITY LOCI; BIPOLAR DISORDER; CHD8 INTERACTS;
SCHIZOPHRENIA
AB Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in patients with autism or related NDDs, revealing disruption of 33 loci in four general categories: (1) genes previously associated with abnormal neurodevelopment (e. g., AUTS2, FOXP1, and CDKL5), (2) single-gene contributors to microdeletion syndromes (MBD5, SATB2, EHMT1, and SNURF-SNRPN), (3) novel risk loci (e. g., CHD8, KIRREL3, and ZNF507), and (4) genes associated with later-onset psychiatric disorders (e. g., TCF4, ZNF804A, PDE10A, GRIN2B, and ANK3). We also discovered among neurodevelopmental cases a profoundly increased burden of copy-number variants from these 33 loci and a significant enrichment of polygenic risk alleles from genome-wide association studies of autism and schizophrenia. Our findings suggest a polygenic risk model of autism and reveal that some neurodevelopmental genes are sensitive to perturbation by multiple mutational mechanisms, leading to variable phenotypic outcomes that manifest at different life stages.
C1 [Talkowski, Michael E.; Blumenthal, Ian; Pillalamarri, Vamsee; Chiang, Colby; Heilbut, Adrian; Ernst, Carl; Hanscom, Carrie; Rossin, Elizabeth; Ruderfer, Douglas; Kirby, Andrew; Ripke, Stephan; Lee, Ji-Hyun; Lucente, Diane; Sims, Katherine; Shen, Yiping; Neale, Benjamin; Daly, Mark J.; Gusella, James F.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
[Rossin, Elizabeth; Kirby, Andrew; Ripke, Stephan; Lage, Kasper; Neale, Benjamin; Daly, Mark J.] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
[Ohsumi, Toshiro K.; Borowsky, Mark L.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA.
[Quade, Bradley; Wu, Bai-Lin; Shen, Yiping; Morton, Cynthia C.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.
[Talkowski, Michael E.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.
[Gusella, James F.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
[Talkowski, Michael E.; Rossin, Elizabeth; Ruderfer, Douglas; Kirby, Andrew; Ripke, Stephan; Lage, Kasper; Neale, Benjamin; Daly, Mark J.; Morton, Cynthia C.; Gusella, James F.] Broad Inst, Program Med & Populat Genet, Cambridge, MA 02143 USA.
[Rosenfeld, Jill A.; Shaffer, Lisa G.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
[Lindgren, Amelia M.; Pereira, Shahrin; Morton, Cynthia C.] Brigham & Womens Hosp, Dept Obstet, Boston, MA 02115 USA.
[Lindgren, Amelia M.; Pereira, Shahrin; Morton, Cynthia C.] Brigham & Womens Hosp, Dept Gynecol, Boston, MA 02115 USA.
[Lindgren, Amelia M.; Pereira, Shahrin; Morton, Cynthia C.] Brigham & Womens Hosp, Dept Reprod Biol, Boston, MA 02115 USA.
[Harris, David J.] Childrens Hosp Boston, Div Clin Genet, Boston, MA 02115 USA.
[Wu, Bai-Lin; Shen, Yiping] Childrens Hosp Boston, Dept Lab Med, Boston, MA 02115 USA.
[Ha, Kyungsoo] Georgia Hlth Sci Univ, Canc Res Ctr, Augusta, GA 30912 USA.
[Kim, Hyung-Goo] Georgia Hlth Sci Univ, Inst Mol Med & Genet, Dept Obstet & Gynecol, Augusta, GA 30912 USA.
[Solomon, Benjamin D.] NHGRI, Med Genet Branch, Bethesda, MD 20892 USA.
[Gropman, Andrea L.] Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA.
[Gropman, Andrea L.] George Washington Univ Hlth Sci, Dept Neurol, Washington, DC 20052 USA.
[Loranger, Stephanie; Daly, Mark J.; Gusella, James F.] Autism Consortium Boston, Boston, MA 02115 USA.
[Lage, Kasper] Massachusetts Gen Hosp, MassGen Hosp Children, Pediat Surg Res Labs, Boston, MA 02114 USA.
[Lage, Kasper] Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark.
[Lage, Kasper] Univ Copenhagen, Ctr Prot Res, DK-1165 Copenhagen, Denmark.
[Miles, Judith] Univ Missouri Hosp & Clin, Thompson Ctr Autism & Neurodev Disorders, Dept Pediat, Columbia, MO 65201 USA.
[Miles, Judith] Univ Missouri Hosp & Clin, Thompson Ctr Autism & Neurodev Disorders, Dept Med Genet, Columbia, MO 65201 USA.
[Miles, Judith] Univ Missouri Hosp & Clin, Thompson Ctr Autism & Neurodev Disorders, Dept Pathol, Columbia, MO 65201 USA.
[Wu, Bai-Lin] Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China.
[Wu, Bai-Lin] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China.
[Shen, Yiping] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200025, Peoples R China.
RP Gusella, JF (reprint author), Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
EM gusella@helix.mgh.harvard.edu
RI Heilbut, Adrian/J-9427-2012; Ruderfer, Douglas/M-5795-2016;
OI Heilbut, Adrian/0000-0002-8169-7967; Ruderfer,
Douglas/0000-0002-2365-386X; Chiang, Colby/0000-0002-4113-6065
FU National Institutes of Health [GM061354, HD065286]; Simons Foundation
Autism Research Initiative; Autism Speaks; Division of Intramural
Research, National Human Genome Research Institute, National Institutes
of Health and Human Services; National Institute of Mental Health
National Research Service [MH087123]; Massachusetts General Hospital
Executive Committee
FX We are grateful to all participating subjects and families and to the
many healthcare professionals who have contributed to this study,
including Mary-Alice Abbott, Darius J. Adams, Kwame Anyane-Yeboa,
Stephen G. Bamforth, Tina Bartell, David P. Bick, Joann N. Bodurtha,
Carol Clericuzio, Stephanie Cohen, Kristin Dalton, Maria Descartes,
Joanne Milisa Drautz, Dawn L. Earl, Luis F. Escobar, Shannon Gerner,
Edwin Guzman, Kenneth Handelman, Tim Heshka, Robert J. Hopkin, Micheil
Innes, Debby Lambert, Emmanuelle Lemyre, Cynthia Lim, Livija Medne,
Graciela Moya, Katie Rutledge, Wendy Smith, Mark Stephan, Darci Sternen,
Katie Stoll, Paulien van Galen, Nancy J. Van Vranken, Erica Wahl, Susan
E. Wiley, Amy L. White, Anne Woods, and Elaine H. Zackai. The invaluable
control data for this study were provided by Pamela Sklar, Shaun
Purcell, the International Schizophrenia Consortium, the Wellcome Trust
Case Control Consortium, Evan Eichler, Bradley Coe, and Greg Cooper. We
thank Tammy Gillis, Mary Anne Anderson, Jayla Ruliera, and Thon de Boer
for technical assistance. We also thank Dennis Gurgul, Nilay Roy, and
Brent Richter of Partners Research Computing at Massachusetts General
Hospital, and contributing staff from Signature Genomic Laboratories and
Children's Hospital Boston. This work was funded by grants GM061354 and
HD065286 from the National Institutes of Health, the Simons Foundation
Autism Research Initiative, and Autism Speaks. This research was also
supported by the Division of Intramural Research, National Human Genome
Research Institute, National Institutes of Health and Human Services. M.
T. was supported by a National Institute of Mental Health National
Research Service Award (MH087123) and an Massachusetts General Hospital
Executive Committee on Research Fund for Medical Discovery Award. L. G.
S. and J. A. R. are employees of Signature Genomic Laboratories,
PerkinElmer.
NR 45
TC 220
Z9 227
U1 3
U2 41
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD APR 27
PY 2012
VL 149
IS 3
DI 10.1016/j.cell.2012.03.028
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 934KN
UT WOS:000303443100006
PM 22521361
ER
PT J
AU Langer, HF
Choi, EY
Zhou, H
Schleicher, R
Chung, KJ
Tang, ZS
Gobel, K
Bdeir, K
Chatzigeorgiou, A
Wong, C
Bhatia, S
Kruhlak, MJ
Rose, JW
Burns, JB
Hill, KE
Qu, HC
Zhang, YQ
Lehrmann, E
Becker, KG
Wang, YM
Simon, DI
Nieswandt, B
Lambris, JD
Li, XR
Meuth, SG
Kubes, P
Chavakis, T
AF Langer, Harald F.
Choi, Eun Young
Zhou, Hong
Schleicher, Rebecca
Chung, Kyoung-Jin
Tang, Zhongshu
Goebel, Kerstin
Bdeir, Khalil
Chatzigeorgiou, Antonios
Wong, Connie
Bhatia, Sumeena
Kruhlak, Michael J.
Rose, John W.
Burns, James B.
Hill, Kenneth E.
Qu, Hongchang
Zhang, Yongqing
Lehrmann, Elin
Becker, Kevin G.
Wang, Yunmei
Simon, Daniel I.
Nieswandt, Bernhard
Lambris, John D.
Li, Xuri
Meuth, Sven G.
Kubes, Paul
Chavakis, Triantafyllos
TI Platelets Contribute to the Pathogenesis of Experimental Autoimmune
Encephalomyelitis
SO CIRCULATION RESEARCH
LA English
DT Article
DE platelets; experimental autoimmune encephalomyelitis; vascular
inflammation; autoimmune disease
ID CENTRAL-NERVOUS-SYSTEM; GLYCOPROTEIN IB-ALPHA; INFLAMMATORY CELL
RECRUITMENT; LEUKOCYTE INTEGRIN MAC-1; MULTIPLE-SCLEROSIS; T-CELLS;
PROGENITOR CELLS; VESSEL WALL; P-SELECTIN; IN-VITRO
AB Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory and autoimmune pathologies is thus far poorly defined.
Objective: We addressed the role of platelets in mediating CNS inflammation in EAE.
Methods and Results: We found that platelets were present in human MS lesions as well as in the CNS of mice subjected to EAE but not in the CNS from control nondiseased mice. Platelet depletion at the effector-inflammatory phase of EAE in mice resulted in significantly ameliorated disease development and progression. EAE suppression on platelet depletion was associated with reduced recruitment of leukocytes to the inflamed CNS, as assessed by intravital microscopy, and with a blunted inflammatory response. The platelet-specific receptor glycoprotein Ib alpha (GPIb alpha) promotes both platelet adhesion and inflammatory actions of platelets and targeting of GPIb alpha attenuated EAE in mice. Moreover, targeting another platelet adhesion receptor, glycoprotein IIb/IIIa (GPIIb/IIIa), also reduced EAE severity in mice.
Conclusions: Platelets contribute to the pathogenesis of EAE by promoting CNS inflammation. Targeting platelets may therefore represent an important new therapeutic approach for MS treatment. (Circ Res. 2012;110:1202-1210.)
C1 [Langer, Harald F.; Schleicher, Rebecca] Univ Tubingen, Med Klin Kardiol & Kreislauferkrankungen 3, D-72076 Tubingen, Germany.
[Langer, Harald F.; Choi, Eun Young; Chung, Kyoung-Jin; Bhatia, Sumeena; Kruhlak, Michael J.; Chavakis, Triantafyllos] NCI, Expt Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Choi, Eun Young; Chung, Kyoung-Jin; Chatzigeorgiou, Antonios; Chavakis, Triantafyllos] Univ Dresden, Dept Internal Med 3, Div Vasc Inflammat Diabet & Kidney, Dresden, Germany.
[Choi, Eun Young; Chung, Kyoung-Jin; Chatzigeorgiou, Antonios; Chavakis, Triantafyllos] Univ Dresden, Inst Physiol, Dresden, Germany.
[Choi, Eun Young] Univ Ulsan, Grad Sch, Dept Med, Seoul, South Korea.
[Zhou, Hong; Wong, Connie; Kubes, Paul] Univ Calgary, Fac Med, Dept Physiol & Biophys, Immunol Res Grp, Calgary, AB, Canada.
[Tang, Zhongshu; Li, Xuri] NEI, NIH, Rockville, MD USA.
[Goebel, Kerstin; Meuth, Sven G.] Univ Munster, Neurol Clin, Inst Physiol, D-4400 Munster, Germany.
[Bdeir, Khalil; Qu, Hongchang; Lambris, John D.] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Rose, John W.; Burns, James B.; Hill, Kenneth E.] VASLCHCS, Neurovirol Res Lab, Salt Lake City, UT USA.
[Zhang, Yongqing; Lehrmann, Elin; Becker, Kevin G.] NIA, Gene Express & Genom Unit, NIH, Baltimore, MD 21224 USA.
[Wang, Yunmei; Simon, Daniel I.] Case Western Reserve Univ, Sch Med, Univ Hosp Harrington McLaughlin Heart & Vasc Inst, Cleveland, OH USA.
[Wang, Yunmei; Simon, Daniel I.] Case Western Reserve Univ, Sch Med, Case Cardiovasc Ctr, Cleveland, OH USA.
[Nieswandt, Bernhard] Univ Wurzburg, DFG Res Ctr Expt Biomed, Chair Vasc Med, D-97070 Wurzburg, Germany.
[Nieswandt, Bernhard] Univ Wurzburg, DFG Res Ctr Expt Biomed, Rudolf Virchow Ctr, D-97070 Wurzburg, Germany.
RP Langer, HF (reprint author), Univ Tubingen, Med Klin Kardiol & Kreislauferkrankungen 3, Otfried Muellerstr 10, D-72076 Tubingen, Germany.
EM Harald.Langer@med.uni-tuebingen.de
OI Lehrmann, Elin/0000-0002-9869-9475; Wong, Connie/0000-0002-9020-1847;
Lambris, John/0000-0002-9370-5776; Becker, Kevin/0000-0002-6794-6656
FU National Institutes of Health [HL57506, HL085816, HL073852]; National
Cancer Institute; National Institute on Aging; National Multiple
Sclerosis Society [RG3411B4/1]; German Research Foundation; Novartis
Foundation for Therapeutic Research; IZKF of the University of Tubingen
[1868-0-0]; Tuebingen Platelet Investigative Consortium (TuePIC);
Clinical Research Unit (KFO) [274]; Volkswagen Foundation
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Cancer Institute (T.C.), and
National Institute on Aging (K.G.B.), the National Institutes of Health
grants HL57506, HL085816, and HL073852 (D.I.S.), the National Multiple
Sclerosis Society grant RG3411B4/1 (J.W.R.), and the German Research
Foundation and the Novartis Foundation for Therapeutic Research (T.C.).
H.F.L. is supported by the IZKF program of the University of Tubingen
(1868-0-0), the Tuebingen Platelet Investigative Consortium (TuePIC),
which is funded by the Clinical Research Unit (KFO 274) of the German
Research Foundation and the Volkswagen Foundation (Lichtenberg program).
NR 60
TC 66
Z9 66
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7330
J9 CIRC RES
JI Circ.Res.
PD APR 27
PY 2012
VL 110
IS 9
BP 1202
EP +
DI 10.1161/CIRCRESAHA.111.256370
PG 35
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Hematology
GA 933ZI
UT WOS:000303406200015
PM 22456181
ER
PT J
AU Bunting, SF
Callen, E
Kozak, ML
Kim, JM
Wong, N
Lopez-Contreras, AJ
Ludwig, T
Baer, R
Faryabi, RB
Malhowski, A
Chen, HT
Fernandez-Capetillo, O
D'Andrea, A
Nussenzweig, A
AF Bunting, Samuel F.
Callen, Elsa
Kozak, Marina L.
Kim, Jung Min
Wong, Nancy
Lopez-Contreras, Andres J.
Ludwig, Thomas
Baer, Richard
Faryabi, Robert B.
Malhowski, Amy
Chen, Hua-Tang
Fernandez-Capetillo, Oscar
D'Andrea, Alan
Nussenzweig, Andre
TI BRCA1 Functions Independently of Homologous Recombination in DNA
Interstrand Crosslink Repair
SO MOLECULAR CELL
LA English
DT Article
ID STRAND-BREAK REPAIR; CLASS-SWITCH RECOMBINATION; FANCONI-ANEMIA PATHWAY;
V(D)J RECOMBINATION; DAMAGE-RESPONSE; CELL-CYCLE; POLY(ADP-RIBOSE)
POLYMERASE; TUMOR SUPPRESSION; DEFICIENT CELLS; 53BP1
AB Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage response factor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice and rescues HR deficiency, as measured by hypersensitivity to polyADP-ribose polymerase (PARP) inhibition. However, Brca1,53BP1 double-deficient cells are hypersensitive to DNA interstrand crosslinks (ICLs), indicating that BRCA1 has an additional role in DNA crosslink repair that is distinct from HR. Disruption of the nonhomologous end-joining (NHEJ) factor, Ku, promotes DNA repair in Brca1-deficient cells; however deletion of either Ku or 53BP1 exacerbates genomic instability in cells lacking FANCD2, a mediator of the Fanconi anemia pathway for ICL repair. BRCA1 therefore has two separate roles in ICL repair that can be modulated by manipulating NHEJ, whereas FANCD2 provides a key activity that cannot be bypassed by ablation of 53BP1 or Ku.
C1 [Bunting, Samuel F.; Callen, Elsa; Kozak, Marina L.; Wong, Nancy; Faryabi, Robert B.; Malhowski, Amy; Chen, Hua-Tang; Nussenzweig, Andre] NCI, Lab Genome Integr, NIH, Bethesda, MD 20892 USA.
[Ludwig, Thomas; Baer, Richard] Columbia Univ, Med Ctr, Irving Canc Res Ctr, Inst Canc Genet, New York, NY 10032 USA.
[Kim, Jung Min; D'Andrea, Alan] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA.
[Lopez-Contreras, Andres J.; Fernandez-Capetillo, Oscar] Spanish Natl Canc Res Ctr, Genom Instabil Grp, Madrid, Spain.
RP Nussenzweig, A (reprint author), NCI, Lab Genome Integr, NIH, 37 Convent Dr,Room 1108, Bethesda, MD 20892 USA.
EM andre_nussenzweig@nih.gov
RI Faryabi, Robert/H-3544-2015; Fernandez-Capetillo, Oscar/H-3508-2015;
Ludwig, Thomas/Q-6484-2016;
OI Faryabi, Robert/0000-0002-7931-2175; Fernandez-Capetillo,
Oscar/0000-0002-2690-6885; Ludwig, Thomas/0000-0003-3461-2585;
Lopez-Contreras, Andres Joaquin/0000-0002-5517-7327
FU NIH; National Cancer Institute; Center for Cancer Research; Department
of Defense [BC102335, K99/R00, 1K99CA160574-01]
FX We thank Laura Niedernhofer, Jeremy Daniel, and Elise Kohn for helpful
discussions and suggestions; Mark O'Connor for Parpi; and Michael
Eckhaus and Mark Bryant for assistance with histology. The work was
supported by the Intramural Research Program of the NIH, the National
Cancer Institute, and the Center for Cancer Research, and by a
Department of Defense grant to A.N. (BC102335) and a K99/R00 grant
(1K99CA160574-01) to S.B. Research was conducted in compliance with the
Animal Welfare Act Regulations and other federal statutes relating to
animals and experiments involving animals and adheres to the principles
set forth in the Guide for Care and Use of Laboratory Animals, National
Research Council, 1996.
NR 56
TC 108
Z9 110
U1 3
U2 23
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD APR 27
PY 2012
VL 46
IS 2
BP 125
EP 135
DI 10.1016/j.molcel.2012.02.015
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 933MH
UT WOS:000303365300004
PM 22445484
ER
PT J
AU Citrin, DE
Hitchcock, YJ
Chung, EJ
Frandsen, J
Urick, ME
Shield, W
Gaffney, D
AF Citrin, Deborah E.
Hitchcock, Ying J.
Chung, Eun Joo
Frandsen, Jonathan
Urick, Mary Ellen
Shield, William
Gaffney, David
TI Determination of cytokine protein levels in oral secretions in patients
undergoing radiotherapy for head and neck malignancies
SO RADIATION ONCOLOGY
LA English
DT Article
DE Saliva; Cytokine; Radiation; Milliplex
ID RADIATION PNEUMONITIS; MARKERS; RISK; BETA
AB Background: Cytokines may be elevated in tumor and normal tissues following irradiation. Cytokine expression in these tissues may predict for toxicity or tumor control. The purpose of this pilot study was to determine the feasibility of measuring local salivary cytokine levels using buccal sponges in patients receiving chemo-radiation for head and neck malignancies.
Patients and methods: 11 patients with epithelial malignancies of the head and neck were recruiting to this study. All patients received radiotherapy to the head and neck region with doses ranging between 60 - 67.5 Gy. Chemotherapy was delivered concurrently with radiation in all patients. Salivary samples were obtained from high dose and low dose regions prior to treatment and at three intervals during treatment for assessment of cytokine levels (IL-4, IL-6, IL-8, IL-10, EGF, MCP-1, TNF-alpha, and VEGF).
Results: Cytokine levels were detectable in the salivary samples. Salivary cytokine levels of IL-4, IL-6, IL-8, EGF, MCP-1, TNF-alpha, and VEGF were higher in the high dose region compared to the low dose region at all time points (p < 0.05). A trend toward an increase in cytokine levels as radiation dose increased was observed for IL-6, IL-8, MCP-1, and TNF-alpha.
Conclusion: Assessment of salivary cytokine levels may provide a novel method to follow local cytokine levels during radiotherapy and may provide a mechanism to study cytokine levels in a regional manner.
C1 [Citrin, Deborah E.; Chung, Eun Joo; Urick, Mary Ellen; Shield, William] NCI, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Hitchcock, Ying J.; Frandsen, Jonathan; Gaffney, David] Univ Utah, Dept Radiat Oncol, Huntsman Canc Inst, Salt Lake City, UT USA.
RP Citrin, DE (reprint author), NCI, Radiat Oncol Branch, Ctr Canc Res, Bldg 10, Bethesda, MD 20892 USA.
EM citrind@mail.nih.gov
FU Intramural Research Program of the NIH, NCI, CCR
FX This research was supported in part by the Intramural Research Program
of the NIH, NCI, CCR.
NR 12
TC 12
Z9 12
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1748-717X
J9 RADIAT ONCOL
JI Radiat. Oncol.
PD APR 26
PY 2012
VL 7
AR 64
DI 10.1186/1748-717X-7-64
PG 6
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 004CK
UT WOS:000308657500001
PM 22537315
ER
PT J
AU Browne, SK
Zaman, R
Sampaio, EP
Jutivorakool, K
Rosen, LB
Ding, L
Pancholi, MJ
Yang, LM
Priel, DL
Uzel, G
Freeman, AF
Hayes, CE
Baxter, R
Cohen, SH
Holland, SM
AF Browne, Sarah K.
Zaman, Rifat
Sampaio, Elizabeth P.
Jutivorakool, Kamonwan
Rosen, Lindsey B.
Ding, Li
Pancholi, Minjal J.
Yang, Lauren M.
Priel, Debra Long
Uzel, Gulbu
Freeman, Alexandra F.
Hayes, Carlton E.
Baxter, Roger
Cohen, Stuart H.
Holland, Steven M.
TI Anti-CD20 (rituximab) therapy for anti-IFN-gamma autoantibody-associated
nontuberculous mycobacterial infection
SO BLOOD
LA English
DT Article
ID INTERFERON-GAMMA; RHEUMATOID-ARTHRITIS; PEMPHIGUS-VULGARIS;
MYASTHENIA-GRAVIS; AVIUM COMPLEX; PATIENT; INTERLEUKIN-12; AUTOIMMUNITY;
RECURRENT; LYMPHOMA
AB Patients with anti-IFN-gamma autoantibodies have impaired IFN-gamma signaling, leading to severe disseminated infections with intracellular pathogens, especially nontuberculous mycobacteria. Disease may be severe and progressive, despite aggressive treatment. To address the underlying pathogenic IFN-gamma autoantibodies we used the therapeutic monoclonal rituximab (anti-CD20) to target patient B cells. All subjects received between 8 and 12 doses of rituximab within the first year to maintain disease remission. Subsequent doses were given for relapsed infection. We report 4 patients with refractory disease treated with rituximab who had clinical and laboratory evidence of therapeutic response as determined by clearance of infection, resolution of inflammation, reduction of anti-IFN-gamma autoantibody levels, and improved IFN-gamma signaling. (Blood. 2012;119(17):3933-3939)
C1 [Browne, Sarah K.; Zaman, Rifat; Sampaio, Elizabeth P.; Jutivorakool, Kamonwan; Rosen, Lindsey B.; Ding, Li; Pancholi, Minjal J.; Yang, Lauren M.; Uzel, Gulbu; Freeman, Alexandra F.; Holland, Steven M.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
[Sampaio, Elizabeth P.] Fiocruz MS, Inst Oswaldo Cruz, Leprosy Lab, BR-21045900 Rio De Janeiro, Brazil.
[Jutivorakool, Kamonwan] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok, Thailand.
[Jutivorakool, Kamonwan] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.
[Yang, Lauren M.] Washington Univ, Sch Med, St Louis, MO USA.
[Priel, Debra Long] SAIC Frederick Inc, Clin Serv Program, Natl Canc Inst Frederick, Frederick, MD USA.
[Hayes, Carlton E.] Jackson Clin, Jackson, TN USA.
[Baxter, Roger] So Calif Permanente Med Grp, Oakland, CA USA.
[Cohen, Stuart H.] Univ Calif Davis, Dept Epidemiol & Infect Control, Davis, CA 95616 USA.
RP Browne, SK (reprint author), CRC B3-4141,MSC 1684, Bethesda, MD 20892 USA.
EM brownesa@niaid.nih.gov
FU Division of Intramural Research; National Institute of Allergy and
Infectious Diseases; National Institutes of Health [HHSN261200800001E];
National Cancer Institute
FX This work was supported by the Division of Intramural Research, National
Institute of Allergy and Infectious Diseases, National Institutes of
Health, and the National Cancer Institute, National Institutes of Health
(contract HHSN261200800001E).
NR 27
TC 42
Z9 42
U1 0
U2 1
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 26
PY 2012
VL 119
IS 17
BP 3933
EP 3939
DI 10.1182/blood-2011-12-395707
PG 7
WC Hematology
SC Hematology
GA 959AU
UT WOS:000305282900014
PM 22403254
ER
PT J
AU Jun, HS
Cheung, YY
Lee, YM
Mansfield, BC
Chou, JY
AF Jun, Hyun Sik
Cheung, Yuk Yin
Lee, Young Mok
Mansfield, Brian C.
Chou, Janice Y.
TI Glucose-6-phosphatase-beta, implicated in a congenital neutropenia
syndrome, is essential for macrophage energy homeostasis and
functionality
SO BLOOD
LA English
DT Article
ID GLYCOGEN-STORAGE-DISEASE; ENDOPLASMIC-RETICULUM; MESOTHELIAL CELLS;
NADPH OXIDASE; PREGNANCY; EXPRESSION; ACTIVATION; PROTEIN; RECRUITMENT;
MUTATIONS
AB Glucose-6-phosphatase-beta (G6Pase-beta or G6PC3) deficiency, also known as severe congenital neutropenia syndrome 4, is characterized not only by neutropenia but also by impaired neutrophil energy homeostasis and functionality. We now show the syndrome is also associated with macrophage dysfunction, with murine G6pc3(-/-) macrophages having impairments in their respiratory burst, chemotaxis, calcium flux, and phagocytic activities. Consistent with a glucose-6-phosphate (G6P) metabolism deficiency, G6pc3(-/-) macrophages also have a lower glucose uptake and lower levels of G6P, lactate, and ATP than wild-type macrophages. Furthermore, the expression of NADPH oxidase subunits and membrane translocation of p47(phox) are down-regulated, and G6pc3(-/-) macrophages exhibit repressed trafficking in vivo both during an inflammatory response and in pregnancy. During pregnancy, the absence of G6Pase-beta activity also leads to impaired energy homeostasis in the uterus and reduced fertility of G6pc3(-/-) mothers. Together these results show that immune deficiencies in this congenital neutropenia syndrome extend beyond neutrophil dysfunction. (Blood. 2012; 119(17):4047-4055)
C1 [Jun, Hyun Sik; Cheung, Yuk Yin; Lee, Young Mok; Mansfield, Brian C.; Chou, Janice Y.] Eunice Kennedy Shriver Natl Inst Child Hlth Human, Sect Cellular Differentiat, Program Dev Endocrinol & Genet, NIH, Bethesda, MD 20892 USA.
RP Chou, JY (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth Human, Sect Cellular Differentiat, Program Dev Endocrinol & Genet, NIH, 9000 Rockville Pike,Bldg 10,Rm 9D42, Bethesda, MD 20892 USA.
EM chouja@mail.nih.gov
RI Jun, Hyun Sik/C-6799-2013
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health
FX This work was supported by the Intramural Research Programs of the
Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health.
NR 46
TC 12
Z9 12
U1 2
U2 3
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 26
PY 2012
VL 119
IS 17
BP 4047
EP 4055
DI 10.1182/blood-2011-09-377820
PG 9
WC Hematology
SC Hematology
GA 959AU
UT WOS:000305282900027
PM 22246029
ER
PT J
AU Glisic, S
Jailwala, P
AF Glisic, Sanja
Jailwala, Parthav
TI Interaction between Treg Apoptosis Pathways, Treg Function and HLA Risk
Evolves during Type 1 Diabetes Pathogenesis
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; MHC CLASS-II; INDUCED CELL-DEATH; HUMAN
T-CELLS; POLYMERASE CHAIN-REACTION; NF-KAPPA-B; OXIDATIVE STRESS; HUMAN
NEUTROPHILS; HIGH-RESOLUTION; MESSENGER-RNA
AB We have previously reported increased apoptosis of regulatory T cells (Tregs) in recent-onset Type 1 Diabetes subjects (RO T1D) in the honeymoon phase and in multiple autoantibody-positive (Ab+) subjects, some of which are developing T1D. We have also reported that increased Treg apoptosis was associated with High HLA risk and that it subsided with cessation of honeymoon period. In this report, we present results generated using genetics, genomics, functional cell-based assays and flow cytometry to assess cellular changes at the T-cell level during T1D pathogenesis. We measured ex vivo Treg apoptosis and Treg function, surface markers expression, expression of HLA class II genes, the influence of HLA risk on Treg apoptosis and function, and evaluated contribution of genes reported to be involved in the apoptosis process. This integrated comprehensive approach uncovered important information that can serve as a basis for future studies aimed to modulate Treg cell responsiveness to apoptotic signals in autoimmunity. For example, T1D will progress in those subjects where increased Treg apoptosis is accompanied with decreased Treg function. Furthermore, Tregs from High HLA risk healthy controls had increased Treg apoptosis levels and overexpressed FADD but not Fas/FasL. Tregs from RO T1D subjects in the honeymoon phase were primarily dying through withdrawal of growth hormones with contribution of oxidative stress, mitochondrial apoptotic pathways, and employment of TNF-receptor family members. Ab+ subjects, however, expressed high inflammation level, which probably contributed to Treg apoptosis, although other apoptotic pathways were also activated: withdrawal of growth hormones, oxidative stress, mitochondrial apoptosis and Fas/FasL apoptotic pathways. The value of these results lie in potentially different preventive treatment subjects would receive depending on disease progression stage when treated.
C1 [Glisic, Sanja] Med Coll Wisconsin, Childrens Hosp Wisconsin, Human & Mol Genet Ctr, Dept Pediat,Max McGee Natl Res Ctr Juvenile Diabe, Milwaukee, WI 53226 USA.
[Jailwala, Parthav] NCI Frederick, SAIC Frederick, Adv Biomed Comp Ctr, Bethesda, MD USA.
RP Glisic, S (reprint author), Med Coll Wisconsin, Childrens Hosp Wisconsin, Human & Mol Genet Ctr, Dept Pediat,Max McGee Natl Res Ctr Juvenile Diabe, Milwaukee, WI 53226 USA.
EM sglisic@mcw.edu
FU Research Affairs Committee [9304653]; Max McGee National Research Center
for Juvenile Diabetes; Human Molecular Genetics Center at Medical
College of Wisconsin; Children's Research Institute of Wisconsin
FX This study was supported by Research Affairs Committee #9304653 and
through Max McGee National Research Center for Juvenile Diabetes, Human
Molecular Genetics Center at Medical College of Wisconsin and Children's
Research Institute of Wisconsin. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 76
TC 2
Z9 2
U1 1
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 26
PY 2012
VL 7
IS 4
AR e36040
DI 10.1371/journal.pone.0036040
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959WQ
UT WOS:000305349100063
PM 22563437
ER
PT J
AU Walsh, RK
Bradley, C
Apperson, CS
Gould, F
AF Walsh, Rachael K.
Bradley, Caitlin
Apperson, Charles S.
Gould, Fred
TI An Experimental Field Study of Delayed Density Dependence in Natural
Populations of Aedes albopictus
SO PLOS ONE
LA English
DT Article
ID TREE-HOLE ECOSYSTEMS; FEEDING-BEHAVIOR; INTERSPECIFIC COMPETITION;
CONTAINER MOSQUITOS; DYNAMICS; CULICIDAE; AEGYPTI; DIPTERA; DETRITUS;
SURVIVAL
AB Aedes albopictus, a species known to transmit dengue and chikungunya viruses, is primarily a container-inhabiting mosquito. The potential for pathogen transmission by Ae. albopictus has increased our need to understand its ecology and population dynamics. Two parameters that we know little about are the impact of direct density-dependence and delayed density-dependence in the larval stage. The present study uses a manipulative experimental design, under field conditions, to understand the impact of delayed density dependence in a natural population of Ae. albopictus in Raleigh, North Carolina. Twenty liter buckets, divided in half prior to experimentation, placed in the field accumulated rainwater and detritus, providing oviposition and larval production sites for natural populations of Ae. albopictus. Two treatments, a larvae present and larvae absent treatment, were produced in each bucket. After five weeks all larvae were removed from both treatments and the buckets were covered with fine mesh cloth. Equal numbers of first instars were added to both treatments in every bucket. Pupae were collected daily and adults were frozen as they emerged. We found a significant impact of delayed density-dependence on larval survival, development time and adult body size in containers with high larval densities. Our results indicate that delayed density-dependence will have negative impacts on the mosquito population when larval densities are high enough to deplete accessible nutrients faster than the rate of natural food accumulation.
C1 [Walsh, Rachael K.; Apperson, Charles S.; Gould, Fred] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA.
[Bradley, Caitlin] Univ N Carolina, Chapel Hill, NC USA.
[Gould, Fred] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Walsh, RK (reprint author), N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA.
EM rskatz@ncsu.edu
FU National Institutes of Health (US) (NIH) [R01-AI54954-0IA2]; Foundation
for the National Institutes of Health through the Grand Challenges in
Global Health initiative
FX This work was supported by National Institutes of Health (US) (NIH)
grant R01-AI54954-0IA2 and a grant to the Regents of the University of
California from the Foundation for the National Institutes of Health
through the Grand Challenges in Global Health initiative. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 42
TC 5
Z9 5
U1 2
U2 25
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 26
PY 2012
VL 7
IS 4
AR e35959
DI 10.1371/journal.pone.0035959
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959WQ
UT WOS:000305349100054
PM 22563428
ER
PT J
AU Spivey, TL
De Giorgi, V
Zhao, YD
Bedognetti, D
Pos, Z
Liu, QZ
Tomei, S
Ascierto, ML
Uccellini, L
Reinboth, J
Chouchane, L
Stroncek, DF
Wang, E
Marincola, FM
AF Spivey, Tara L.
De Giorgi, Valeria
Zhao, Yingdong
Bedognetti, Davide
Pos, Zoltan
Liu, Qiuzhen
Tomei, Sara
Ascierto, Maria Libera
Uccellini, Lorenzo
Reinboth, Jennifer
Chouchane, Lotfi
Stroncek, David F.
Wang, Ena
Marincola, Francesco M.
TI The stable traits of melanoma genetics: an alternate approach to target
discovery
SO BMC GENOMICS
LA English
DT Article
DE Melanoma; Melanoma genetics; Cancer; Tumor microenvironment
ID COMPARATIVE GENOMIC HYBRIDIZATION; COLORECTAL-CANCER; PROGNOSTIC
RELEVANCE; ACQUIRED-RESISTANCE; MALIGNANT-MELANOMA; ANTIGEN EXPRESSION;
TISSUE MICROARRAY; CELL CARCINOMA; T-CELLS; TUMORS
AB Background: The weight that gene copy number plays in transcription remains controversial; although in specific cases gene expression correlates with copy number, the relationship cannot be inferred at the global level. We hypothesized that genes steadily expressed by 15 melanoma cell lines (CMs) and their parental tissues (TMs) should be critical for oncogenesis and their expression most frequently influenced by their respective copy number.
Results: Functional interpretation of 3,030 transcripts concordantly expressed (Pearson's correlation coefficient p-value < 0.05) by CMs and TMs confirmed an enrichment of functions crucial to oncogenesis. Among them, 968 were expressed according to the transcriptional efficiency predicted by copy number analysis (Pearson's correlation coefficient p-value < 0.05). We named these genes, "genomic delegates" as they represent at the transcriptional level the genetic footprint of individual cancers. We then tested whether the genes could categorize 112 melanoma metastases. Two divergent phenotypes were observed: one with prevalent expression of cancer testis antigens, enhanced cyclin activity, WNT signaling, and a Th17 immune phenotype (Class A). This phenotype expressed, therefore, transcripts previously associated to more aggressive cancer. The second class (B) prevalently expressed genes associated with melanoma signaling including MITF, melanoma differentiation antigens, and displayed a Th1 immune phenotype associated with better prognosis and likelihood to respond to immunotherapy. An intermediate third class (C) was further identified. The three phenotypes were confirmed by unsupervised principal component analysis.
Conclusions: This study suggests that clinically relevant phenotypes of melanoma can be retraced to stable oncogenic properties of cancer cells linked to their genetic back bone, and offers a roadmap for uncovering novel targets for tailored anti-cancer therapy.
C1 [Spivey, Tara L.; De Giorgi, Valeria; Bedognetti, Davide; Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; Uccellini, Lorenzo; Reinboth, Jennifer; Wang, Ena; Marincola, Francesco M.] NIH, Infect Dis & Immunogenet Sect IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
[Spivey, Tara L.] NIH, Clin Res Training Program CRTP, Bethesda, MD 20892 USA.
[Spivey, Tara L.] Rush Univ, Med Ctr, Rush Med Coll, Chicago, IL 60612 USA.
[Zhao, Yingdong] NCI, Biometr Res Branch, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
[Bedognetti, Davide; Ascierto, Maria Libera] Univ Genoa, Dept Internal Med DiMI, I-16132 Genoa, Italy.
[Bedognetti, Davide] Natl Canc Res Inst Genoa, Genoa, Italy.
[Bedognetti, Davide] Dept Oncol Biol & Genet, Genoa, Italy.
[Pos, Zoltan] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary.
[Tomei, Sara] Univ Pisa, Dept Oncol, Pisa, Italy.
[Ascierto, Maria Libera] Univ Genoa, Ctr Excellence Biomed Res CEBR, Genoa, Italy.
[Chouchane, Lotfi] Weill Cornell Med Coll Qatar, Doha, Qatar.
[Stroncek, David F.] NIH, Cell Proc Sect, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
[Uccellini, Lorenzo] Univ Milan, Inst Infect & Trop Dis, L Sacco Hosp, Milan, Italy.
[Reinboth, Jennifer] Genelux Corp, San Diego Sci Ctr, San Diego, CA USA.
[Reinboth, Jennifer] Univ Wurzburg, Dept Biochem, Bioctr, D-97074 Wurzburg, Germany.
[Marincola, Francesco M.] NIH, Infect Dis & Immunogenet Sect IDIS, Dept Transfus Med, Ctr Human Immunol CHI, Bethesda, MD 20892 USA.
[Spivey, Tara L.; De Giorgi, Valeria; Bedognetti, Davide; Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; Uccellini, Lorenzo; Reinboth, Jennifer; Wang, Ena; Marincola, Francesco M.] NIH, Infect Dis & Immunogenet Sect IDIS, Dept Transfus Med, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA.
RP De Giorgi, V (reprint author), NIH, Infect Dis & Immunogenet Sect IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM degiorgiv@mail.nih.gov; FMarincola@mail.cc.nih.gov
RI Pos, Zoltan/C-3623-2014; De Giorgi, Valeria/D-4582-2017;
OI Pos, Zoltan/0000-0002-2574-7616; Bedognetti, Davide/0000-0002-5857-773X
FU NIH; Pfizer Inc.
FX Tara Spivey's research fellowship was made possible through the Clinical
Research Training Program, a public-private partnership supported
jointly by the NIH and Pfizer Inc. (via a grant to the foundation for
NIH from Pfizer Inc.).
NR 46
TC 20
Z9 20
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD APR 26
PY 2012
VL 13
AR 156
DI 10.1186/1471-2164-13-156
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 949HR
UT WOS:000304567800001
PM 22537248
ER
PT J
AU Xu, Y
Ma, BY
Nussinov, R
AF Xu, Yu
Ma, Buyong
Nussinov, Ruth
TI Structural and Functional Consequences of Phosphate-Arsenate
Substitutions in Selected Nucleotides: DNA, RNA, and ATP
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; CONFORMATIONAL PROPERTIES; POTENTIAL
FUNCTIONS; LIQUID WATER; FORCE-FIELD; RIBOSOME; PHOSPHORUS; BACTERIUM;
PROTEIN; GROW
AB A recent finding of a bacterial strain (GFAJ-1) that can rely on arsenic instead of phosphorus raised the questions of if and how arsenate can replace phosphate in biomolecules that are essential to sustain cell life. Apart from questions related to chemical stability, there are those of the structural and functional consequences of phosphate-arsenate substitutions in vital nucleotides in GFAJ1-like cells. In this study we selected three types of molecules (ATP/ADP as energy source and replication regulation; DNA protein complexes for DNA replication and transcription initiation; and a tRNA protein complex and ribosome for protein synthesis) to computationally probe if arsenate nucleotides can retain the structural and functional features of phosphate nucleotides. Hydrolysis of adenosine triarsenate provides 2-3 kcal/mol less energy than ATP hydrolysis. Arsenate DNA/RNA interacts with proteins slightly less strongly than phosphate DNA/RNA, mainly due to the weaker electrostatic interactions of arsenate. We observed that the weaker arsenate RNA protein interactions may hamper rRNA assembly into a functional ribosome. We further compared the experimental EXAFS spectra of the arsenic bacteria with theoretical EXAFS spectra for arsenate DNA and rRNA. Our results demonstrate that while it is possible that dried GFAJ-1 cells contain linear arsenate DNA, the arsenate 70S ribosome does not contribute to the main arsenate depository in the GFAJ-1 cell. Our study indicates that evolution has optimized the inter-relationship between proteins and DNA/RNA, which requires overall changes at the molecular and systems biology levels when replacing phosphate by arsenate.
C1 [Ma, Buyong] NCI, Basic Sci Program, SAIC Frederick Inc, Ctr Canc Res Nanobiol Program,NIH, Frederick, MD 21702 USA.
[Xu, Yu; Nussinov, Ruth] Minzu Univ China, Inst Chinese Minor Tradit Med, Beijing 100081, Peoples R China.
[Nussinov, Ruth] Tel Aviv Univ, Sackler Sch Med, Sackler Inst Mol Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel.
RP Ma, BY (reprint author), NCI, Basic Sci Program, SAIC Frederick Inc, Ctr Canc Res Nanobiol Program,NIH, Frederick, MD 21702 USA.
EM mabuyong@mail.nih.gov; ruthnu@helix.nih.gov
RI Ma, Buyong/F-9491-2011
OI Ma, Buyong/0000-0002-7383-719X
FU National Cancer Institute, National Institutes of Health
[HHSN261200800001E]; China Scholarship Council; NIH, NCI, Center for
Cancer Research
FX This project has been funded in whole or in part with Federal funds from
the National Cancer Institute, National Institutes of Health, under
contract number HHSN261200800001E. Y.X. thanks the China Scholarship
Council [2009]3009. This research was supported (in part) by the
Intramural Research Program of the NIH, NCI, Center for Cancer Research.
All simulations were performed using the high-performance computational
facilities of the Biowulf PC/Limix cluster at the NIH, Bethesda, MD
(http://biowulf.nih.gov).
NR 56
TC 8
Z9 8
U1 1
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD APR 26
PY 2012
VL 116
IS 16
BP 4801
EP 4811
DI 10.1021/jp300307u
PG 11
WC Chemistry, Physical
SC Chemistry
GA 930VX
UT WOS:000303173800009
PM 22480264
ER
PT J
AU Montesarchio, V
Grimaldi, AM
Fox, BA
Rea, A
Marincola, FM
Ascierto, PA
AF Montesarchio, Vincenzo
Grimaldi, Antonio Maria
Fox, Bernard A.
Rea, Antonio
Marincola, Francesco M.
Ascierto, Paolo A.
TI Lean oncology: a new model for oncologists
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Editorial Material
AB The history of the term Lean is relatively recent and originates from the Toyota Production System (TPS). The term "Lean" means "thin", which refers to a mental process, operational, productive, no-frills, quick but not hasty, consequential to the previous event. The Lean process flows seamlessly into the result, eliminates unnecessary complications to the effect, prevents unnecessary equipment processes. The idea is to 'do more with less', like using the (few) available resources in the most productive way possible, through the elimination of all types of waste that inevitably accompanies every stage of a production process. Lean management is primarily a management philosophy, a system of values and behaviors that goes beyond the mere application of the instrument and that, once internalized, will form the nucleus of the corporate culture. "Lean Oncology" is a term coined to identify a methodology of care and treatment to cancer patients, consisting on process simplification, streamlining of the organizational and routes of drug treatment, detection and elimination of waste. Its main objective is the centrality of the patient.
C1 [Grimaldi, Antonio Maria; Ascierto, Paolo A.] Ist Nazl Studio & Cura Tumori Fdn G Pascale, Unit Med Oncol & Innovat Therapy, I-80131 Naples, Italy.
[Montesarchio, Vincenzo; Rea, Antonio] Osped D Cotugno AORN Colli, Unit Med Oncol, I-80131 Naples, Italy.
[Fox, Bernard A.] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA.
[Fox, Bernard A.] Oregon Hlth & Sci Univ, Providence Portland Med Ctr, Robert W Franz Res Ctr, Earle A Chiles Res Inst, Portland, OR 97201 USA.
[Marincola, Francesco M.] Clin Ctr & Trans NIH, Infect Dis & Immunogenet Sect, Bethesda, MD USA.
RP Ascierto, PA (reprint author), Ist Nazl Studio & Cura Tumori Fdn G Pascale, Unit Med Oncol & Innovat Therapy, Via Mariano Semmola, I-80131 Naples, Italy.
EM paolo.ascierto@gmail.com
FU Intramural NIH HHS [Z99 CL999999]
NR 0
TC 2
Z9 3
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD APR 25
PY 2012
VL 10
AR 74
DI 10.1186/1479-5876-10-74
PG 3
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 033LA
UT WOS:000310796400001
PM 22533796
ER
PT J
AU Garzon-Martinez, GA
Zhu, ZI
Landsman, D
Barrero, LS
Marino-Ramirez, L
AF Garzon-Martinez, Gina A.
Zhu, Z. Iris
Landsman, David
Barrero, Luz S.
Marino-Ramirez, Leonardo
TI The Physalis peruviana leaf transcriptome: assembly, annotation and gene
model prediction
SO BMC GENOMICS
LA English
DT Article
DE P. peruviana; Solanaceae; ESTs; Functional annotation; Gene model;
Phylogenetics
ID NORMALIZED CDNA LIBRARY; HIGH-THROUGHPUT; DISEASE RESISTANCE; PLANT
DEFENSE; EST-SSRS; SOLANACEAE; DISCOVERY; IDENTIFICATION; GENERATION;
EVOLUTION
AB Background: Physalis peruviana commonly known as Cape gooseberry is a member of the Solanaceae family that has an increasing popularity due to its nutritional and medicinal values. A broad range of genomic tools is available for other Solanaceae, including tomato and potato. However, limited genomic resources are currently available for Cape gooseberry.
Results: We report the generation of a total of 652,614 P. peruviana Expressed Sequence Tags (ESTs), using 454 GS FLX Titanium technology. ESTs, with an average length of 371 bp, were obtained from a normalized leaf cDNA library prepared using a Colombian commercial variety. De novo assembling was performed to generate a collection of 24,014 isotigs and 110,921 singletons, with an average length of 1,638 bp and 354 bp, respectively. Functional annotation was performed using NCBI's BLAST tools and Blast2GO, which identified putative functions for 21,191 assembled sequences, including gene families involved in all the major biological processes and molecular functions as well as defense response and amino acid metabolism pathways. Gene model predictions in P. peruviana were obtained by using the genomes of Solanum lycopersicum (tomato) and Solanum tuberosum (potato). We predict 9,436 P. peruviana sequences with multiple-exon models and conserved intron positions with respect to the potato and tomato genomes. Additionally, to study species diversity we developed 5,971 SSR markers from assembled ESTs.
Conclusions: We present the first comprehensive analysis of the Physalis peruviana leaf transcriptome, which will provide valuable resources for development of genetic tools in the species. Assembled transcripts with gene models could serve as potential candidates for marker discovery with a variety of applications including: functional diversity, conservation and improvement to increase productivity and fruit quality. P. peruviana was estimated to be phylogenetically branched out before the divergence of five other Solanaceae family members, S. lycopersicum, S. tuberosum, Capsicum spp, S. melongena and Petunia spp.
C1 [Garzon-Martinez, Gina A.; Barrero, Luz S.; Marino-Ramirez, Leonardo] Colombian Corp Agr Res CORPOICA, Plant Mol Genet Lab, Ctr Biotechnol & Bioind, Bogota, Colombia.
[Zhu, Z. Iris; Landsman, David; Marino-Ramirez, Leonardo] Natl Lib Med, Computat Biol Branch, Natl Ctr Biotechnol Informat, Bethesda, MD USA.
[Barrero, Luz S.; Marino-Ramirez, Leonardo] PanAmer Bioinformat Inst, Magdalena, Colombia.
RP Marino-Ramirez, L (reprint author), Colombian Corp Agr Res CORPOICA, Plant Mol Genet Lab, Ctr Biotechnol & Bioind, Bogota, Colombia.
EM marino@ncbi.nlm.nih.gov
RI Marino-Ramirez, Leonardo/I-5759-2013;
OI Marino-Ramirez, Leonardo/0000-0002-5716-8512; Landsman,
David/0000-0002-9819-6675
FU Colombian Ministry of Agriculture [054/08072-2008 L4787-3281,
054/08190-2008 L7922-3322]; Colciencias "Joven Investigador" Fellowship;
National Institutes of Health, National Library of Medicine; National
Center for Biotechnology Information
FX Support for this research was provided by a grant from the Colombian
Ministry of Agriculture Contract Nos. 054/08072-2008 L4787-3281 to Luz
Stella Barrero and 054/08190-2008 L7922-3322 to Victor Manuel Nunez
Zarantes. Gina Garzon-Martinez was supported by a Colciencias "Joven
Investigador" Fellowship during 2010. Leonardo Marino-Ramirez expresses
his deepest gratitude to his friend and colleague Dr. Alba Marina Cotes
Prado for all the advice and support she gave him to conduct this
project. This research was supported in part by the Intramural Research
Program of the National Institutes of Health, National Library of
Medicine, and National Center for Biotechnology Information.
NR 56
TC 18
Z9 19
U1 2
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD APR 25
PY 2012
VL 13
AR 151
DI 10.1186/1471-2164-13-151
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 979WZ
UT WOS:000306855100001
PM 22533342
ER
PT J
AU Major, JM
Kiruthu, C
Weinstein, SJ
Horst, RL
Snyder, K
Virtamo, J
Albanes, D
AF Major, Jacqueline M.
Kiruthu, Christine
Weinstein, Stephanie J.
Horst, Ronald L.
Snyder, Kirk
Virtamo, Jarmo
Albanes, Demetrius
TI Pre-Diagnostic Circulating Vitamin D and Risk of Melanoma in Men
SO PLOS ONE
LA English
DT Article
ID MALIGNANT-MELANOMA; SUN EXPOSURE; CANCER
AB Purpose: Various studies have examined the association between serum vitamin D levels and different cancers; however, this is the first prospective study of this association with melanoma risk. The aim of this study is to investigate the association between serum vitamin D [25(OH)D] levels and melanoma in a cohort of older, middle-aged Finnish male smokers.
Methods: We conducted a nested case-control study within the Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study. From the ATBC cohort, 368 subjects were chosen for our study; 92 participants that developed melanoma and 276 matched control subjects. At study baseline, lifestyle questionnaires and blood samples were collected. Serum 25(OH)D was modeled as three sets of categorical variables: clinically-defined categories, season-specific quartiles and season-adjusted residual quartiles. Conditional logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (95% CIs) to estimate the association between circulating vitamin D and melanoma risk.
Results: Overall no association of serum 25(OH)D and melanoma risk was observed. A decreased risk of developing melanoma was observed in the middle categories compared to the lowest category, albeit not significant.
Conclusion: Results indicate no association between serum 25(OH)D levels and melanoma. Additional studies, including possibly consortium efforts, are needed to investigate the association between serum 25(OH)D levels and risk of melanoma in larger, more diverse study populations.
C1 [Major, Jacqueline M.; Kiruthu, Christine; Weinstein, Stephanie J.; Albanes, Demetrius] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Horst, Ronald L.] Heartland Assays Inc, Ames, IA USA.
[Snyder, Kirk] Informat Management Serv Inc, Silver Spring, MD USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
RP Major, JM (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
EM jacqueline.major@nih.gov
RI Albanes, Demetrius/B-9749-2015
FU National Cancer Institute, NIH; US Public Health Service from the
National Cancer Institute, NIH, DHHS [N01-CN-45165, N01-RC-45035,
N01-RC-37004, HHSN261201000006C]
FX The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study is
supported by the Intramural Research Program of the National Cancer
Institute, NIH, and by US Public Health Service contracts N01-CN-45165,
N01-RC-45035, N01-RC-37004, and HHSN261201000006C from the National
Cancer Institute, NIH, DHHS. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript. Ronald L. Horst is an employee of Heartland Assays, Inc.,
and Kirk Snyder is an analytic programmer employed by Information
Management Services, Inc. These authors played a role in performing the
experiments and analysis of the data.
NR 28
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U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 25
PY 2012
VL 7
IS 4
AR e35112
DI 10.1371/journal.pone.0035112
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959VP
UT WOS:000305345200026
PM 22558121
ER
PT J
AU Stroh, O
Freichel, M
Kretz, O
Birnbaumer, L
Hartmann, J
Egger, V
AF Stroh, Olga
Freichel, Marc
Kretz, Oliver
Birnbaumer, Lutz
Hartmann, Jana
Egger, Veronica
TI NMDA Receptor-Dependent Synaptic Activation of TRPC Channels in
Olfactory Bulb Granule Cells
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID METABOTROPIC GLUTAMATE RECEPTORS; NONSELECTIVE CATIONIC CURRENT;
LONG-LASTING DEPOLARIZATIONS; GABA RELEASE; MITRAL CELLS;
DENDRODENDRITIC INHIBITION; RECIPROCAL SYNAPSES; POTENTIAL CHANNELS;
PHOSPHOLIPASE-C; CALCIUM INFLUX
AB Canonical transient receptor potential (TRPC) channels are widely expressed throughout the nervous system including the olfactory bulb where their function is largely unknown. Here, we describe their contribution to central synaptic processing at the reciprocal mitral and tufted cell-granule cell microcircuit, the most abundant synapse of the mammalian olfactory bulb. Suprathreshold activation of the synapse causes sodium action potentials in mouse granule cells and a subsequent long-lasting depolarization (LLD) linked to a global dendritic postsynaptic calcium signal recorded with two-photon laser-scanning microscopy. These signals are not observed after action potentials evoked by current injection in the same cells. The LLD persists in the presence of group I metabotropic glutamate receptor antagonists but is entirely absent from granule cells deficient for the NMDA receptor subunit NR1. Moreover, both depolarization and Ca2+ rise are sensitive to the blockade of NMDA receptors. The LLD and the accompanying Ca2+ rise are also absent in granule cells from mice deficient for both TRPC channel subtypes 1 and 4, whereas the deletion of either TRPC1 or TRPC4 results in only a partial reduction of the LLD. Recordings from mitral cells in the absence of both subunits reveal a reduction of asynchronous neurotransmitter release from the granule cells during recurrent inhibition. We conclude that TRPC1 and TRPC4 can be activated downstream of NMDA receptor activation and contribute to slow synaptic transmission in the olfactory bulb, including the calcium dynamics required for asynchronous release from the granule cell spine.
C1 [Egger, Veronica] Univ Munich, Div Neurobiol, Dept Biol 2, D-82152 Martinsried, Germany.
[Stroh, Olga; Egger, Veronica] Univ Munich, Inst Physiol, D-80336 Munich, Germany.
[Freichel, Marc] Univ Saarland, Inst Pharmacol & Toxicol, D-66421 Homburg, Germany.
[Kretz, Oliver] Univ Freiburg, Inst Anat & Cell Biol, Dept Neuroanat, D-79104 Freiburg, Germany.
[Birnbaumer, Lutz] NIEHS, Res Triangle Pk, NC 27709 USA.
[Hartmann, Jana] Tech Univ Munich, Inst Neurosci, D-80802 Munich, Germany.
RP Egger, V (reprint author), Univ Munich, Div Neurobiol, Dept Biol 2, Grosshadernerstr 2, D-82152 Martinsried, Germany.
EM v.egger@lmu.de
RI Hartmann, Jana/C-1024-2008
FU Deutsche Forschungsgemeinschaft [SFB 391, SFB 870, SPP 1392, SFB 530];
NIH [Z01-ES-101684]
FX This work was supported by Deutsche Forschungsgemeinschaft Grants SFB
391 (O.S.,V.E.), SFB 870 and SPP 1392 (V.E.), and SFB 530 (M.F.), and by
NIH Intramural Research Program Grant Z01-ES-101684 (L.B.). We thank A.
Schafer, T. Kuner, and P. Seeburg for the GluR NR1 2lox mice,
V. Flockerzi for anti-TRPC1, anti-TRPC4, and anti-TRPC5 antibodies, B.
Sutor and A. Konnerth for support, and I. Schneider, H. Jacobi, and R.
Waberer for technical assistance. The authors declare no competing
financial interests.
NR 71
TC 25
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U1 0
U2 6
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 25
PY 2012
VL 32
IS 17
BP 5737
EP 5746
DI 10.1523/JNEUROSCI.3753-11.2012
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 933VU
UT WOS:000303393000005
PM 22539836
ER
PT J
AU Grishaev, A
Ying, JF
Bax, A
AF Grishaev, Alexander
Ying, Jinfa
Bax, Ad
TI Imino Hydrogen Positions in Nucleic Acids from Density Functional Theory
Validated by NMR Residual Dipolar Couplings
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID GLOBAL STRUCTURE DETERMINATION; MOLECULAR-ORBITAL METHODS; HUMAN
TELOMERASE RNA; X-RAY-SCATTERING; BASE-PAIRS; BASIS-SET; DYNAMICS;
PROTEINS; BONDS
AB Hydrogen atom positions of nucleotide bases in RNA structures solved by X-ray crystallography are commonly derived from heavy-atom coordinates by assuming idealized geometries. In particular, N1-H1 vectors in G and N3-H3 vectors in U are commonly positioned to coincide with the bisectors of their respective heavy-atom angles. We demonstrate that quantum-mechanical optimization of the hydrogen positions relative to their heavy-atom frames considerably improves the fit of experimental residual dipolar couplings to structural coordinates. The calculations indicate that deviations of the imino N-H vectors in RNA U and G bases result from H-bonding within the base pair and are dominated by the attractive interaction between the H atom and the electron density surrounding the H-bond-acceptor atom. DFT optimization of H atom positions is impractical in structural biology studies. We therefore have developed an empirical relation that predicts imino N-H vector orientations from the heavy-atom coordinates of the base pair. This relation agrees very closely with the DFT results, permitting its routine application in structural studies.
C1 [Grishaev, Alexander; Ying, Jinfa; Bax, Ad] NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA.
RP Bax, A (reprint author), NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA.
EM bax@nih.gov
FU National Institute of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health (NIH); Office of the Director, NIH
FX We thank Dr. Fernando Clemente of Gaussian, Inc. for helpful discussions
and Dr. Yun-Xing Wang for the RiboA sample. This study utilized the
high-performance computational capabilities of the Biowulf Linux cluster
at the National Institutes of Health, Bethesda, Maryland
(http://biowulf.nih.gov). This work was funded by the Intramural
Research Program of the National Institute of Diabetes and Digestive and
Kidney Diseases, National Institutes of Health (NIH), and the Intramural
AIDS-Targeted Antiviral Program of the Office of the Director, NIH.
NR 26
TC 3
Z9 3
U1 1
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD APR 25
PY 2012
VL 134
IS 16
BP 6956
EP 6959
DI 10.1021/ja301775j
PG 4
WC Chemistry, Multidisciplinary
SC Chemistry
GA 930LB
UT WOS:000303139800018
PM 22489834
ER
PT J
AU Silverman, JL
Smith, DG
Rizzo, SJS
Karras, MN
Turner, SM
Tolu, SS
Bryce, DK
Smith, DL
Fonseca, K
Ring, RH
Crawley, JN
AF Silverman, Jill L.
Smith, Daniel G.
Rizzo, Stacey J. Sukoff
Karras, Michael N.
Turner, Sarah M.
Tolu, Seda S.
Bryce, Dianne K.
Smith, Deborah L.
Fonseca, Kari
Ring, Robert H.
Crawley, Jacqueline N.
TI Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive
Behaviors and Rescues Social Deficits in Mouse Models of Autism
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID FRAGILE-X-SYNDROME; MUTANT MICE DISPLAY; BTBR-T+TF/J MICE; SPECTRUM
DISORDER; CORPUS-CALLOSUM; RETT-SYNDROME; ULTRASONIC VOCALIZATIONS;
TUBEROUS-SCLEROSIS; MENTAL-RETARDATION; LOW SOCIABILITY
AB Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to be medically un-treatable, on the assumption that brain dysfunctions were immutably hardwired before diagnosis. Recent revelations that many cases of autism are caused by mutations in genes that control the ongoing formation and maturation of synapses have challenged this dogma. Antagonists of metabotropic glutamate receptor subtype 5 (mGluR5), which modulate excitatory neurotransmission, are in clinical trials for fragile X syndrome, a major genetic cause of intellectual disabilities. About 30% of patients with fragile X syndrome meet the diagnostic criteria for autism. Reasoning by analogy, we considered the mGluR5 receptor as a potential target for intervention in autism. We used BTBR T+tf/J (BTBR) mice, an established model with robust behavioral phenotypes relevant to the three diagnostic behavioral symptoms of autism-unusual social interactions, impaired communication, and repetitive behaviors-to probe the efficacy of a selective negative allosteric modulator of the mGluR5 receptor, GRN-529. GRN-529 reduced repetitive behaviors in three cohorts of BTBR mice at doses that did not induce sedation in control assays of open field locomotion. In addition, the same nonsedating doses reduced the spontaneous stereotyped jumping that characterizes a second inbred strain of mice, C58/J. Further, GRN-529 partially reversed the striking lack of sociability in BTBR mice on some parameters of social approach and reciprocal social interactions. These findings raise the possibility that a single targeted pharmacological intervention may alleviate multiple diagnostic behavioral symptoms of autism.
C1 [Silverman, Jill L.; Karras, Michael N.; Turner, Sarah M.; Tolu, Seda S.; Crawley, Jacqueline N.] NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA.
[Smith, Daniel G.; Rizzo, Stacey J. Sukoff; Bryce, Dianne K.; Smith, Deborah L.; Fonseca, Kari; Ring, Robert H.] Pfizer Worldwide Res & Dev, Groton, CT 06340 USA.
RP Crawley, JN (reprint author), NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA.
EM crawleyj@mail.nih.gov
RI Ring, Robert/M-1238-2016
OI Ring, Robert/0000-0002-7037-4409
FU NIMH; Pfizer Global Research
FX This work was supported by the NIMH Intramural Research Program (J.L.S.,
M.N.K., S.M.T., S.S.T., and J.N.C.) and Pfizer Global Research (D.G.S.,
S.J.S.R., D.K.B., D.L.S., K.F., and R.H.R.).
NR 103
TC 56
Z9 57
U1 4
U2 23
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD APR 25
PY 2012
VL 4
IS 131
AR 131ra51
DI 10.1126/scitranslmed.3003501
PG 9
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA 933UM
UT WOS:000303388900005
PM 22539775
ER
PT J
AU Perin, EC
Willerson, JT
Pepine, CJ
Henry, TD
Ellis, SG
Zhao, DXM
Silva, GV
Lai, DJ
Thomas, JD
Kronenberg, MW
Martin, AD
Anderson, RD
Traverse, JH
Penn, MS
Anwaruddin, S
Hatzopoulos, AK
Gee, AP
Taylor, DA
Cogle, CR
Smith, D
Westbrook, L
Chen, J
Handberg, E
Olson, RE
Geither, C
Bowman, S
Francescon, J
Baraniuk, S
Piller, LB
Simpson, LM
Loghin, C
Aguilar, D
Richman, S
Zierold, C
Bettencourt, J
Sayre, SL
Vojvodic, RW
Skarlatos, SI
Gordon, DJ
Ebert, RF
Kwak, M
Moye, LA
Simari, RD
AF Perin, Emerson C.
Willerson, James T.
Pepine, Carl J.
Henry, Timothy D.
Ellis, Stephen G.
Zhao, David X. M.
Silva, Guilherme V.
Lai, Dejian
Thomas, James D.
Kronenberg, Marvin W.
Martin, A. Daniel
Anderson, R. David
Traverse, Jay H.
Penn, Marc S.
Anwaruddin, Saif
Hatzopoulos, Antonis K.
Gee, Adrian P.
Taylor, Doris A.
Cogle, Christopher R.
Smith, Deirdre
Westbrook, Lynette
Chen, James
Handberg, Eileen
Olson, Rachel E.
Geither, Carrie
Bowman, Sherry
Francescon, Judy
Baraniuk, Sarah
Piller, Linda B.
Simpson, Lara M.
Loghin, Catalin
Aguilar, David
Richman, Sara
Zierold, Claudia
Bettencourt, Judy
Sayre, Shelly L.
Vojvodic, Rachel W.
Skarlatos, Sonia I.
Gordon, David J.
Ebert, Ray F.
Kwak, Minjung
Moye, Lemuel A.
Simari, Robert D.
CA Cardiovasc Cell Therapy Res Networ
TI Effect of Transendocardial Delivery of Autologous Bone Marrow
Mononuclear Cells on Functional Capacity, Left Ventricular Function, and
Perfusion in Chronic Heart Failure The FOCUS-CCTRN Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; ACUTE MYOCARDIAL-INFARCTION;
CORONARY-ARTERY-DISEASE; RESEARCH NETWORK CCTRN; STEM-CELLS; PROGENITOR
CELLS; TRANSCORONARY TRANSPLANTATION; INTRAMYOCARDIAL INJECTION; F-18
FLUORODEOXYGLUCOSE; METABOLIC-ACTIVITY
AB Context Previous studies using autologous bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy.
Objective To determine if administration of BMCs through transendocardial injections improves myocardial perfusion, reduces left ventricular end-systolic volume (LVESV), or enhances maximal oxygen consumption in patients with coronary artery disease or LV dysfunction, and limiting heart failure or angina.
Design, Setting, and Patients Aphase 2 randomized double-blind, placebo-controlled trial of symptomatic patients (New York Heart Association classification II-III or Canadian Cardiovascular Society classification II-IV) with a left ventricular ejection fraction of 45% or less, a perfusion defect by single-photon emission tomography (SPECT), and coronary artery disease not amenable to revascularization who were receiving maximal medical therapy at 5 National Heart, Lung, and Blood Institute-sponsored Cardiovascular Cell Therapy Research Network (CCTRN) sites between April 29, 2009, and April 18, 2011.
Intervention Bone marrow aspiration (isolation of BMCs using a standardized automated system performed locally) and transendocardial injection of 100 million BMCs or placebo (ratio of 2 for BMC group to 1 for placebo group).
Main Outcome Measures Co-primary end points assessed at 6 months: changes in LVESV assessed by echocardiography, maximal oxygen consumption, and reversibility on SPECT. Phenotypic and functional analyses of the cell product were performed by the CCTRN biorepository core laboratory.
Results Of 153 patients who provided consent, a total of 92 (82 men; average age: 63 years) were randomized (n=61 in BMC group and n=31 in placebo group). Changes in LVESV index (-0.9 mL/m(2) [95% CI, -6.1 to 4.3]; P=.73), maximal oxygen consumption (1.0 [95% CI, -0.42 to 2.34]; P=.17), and reversible defect (-1.2 [95% CI, -12.50 to 10.12]; P=.84) were not statistically significant. There were no differences found in any of the secondary outcomes, including percent myocardial defect, total defect size, fixed defect size, regional wall motion, and clinical improvement.
Conclusion Among patients with chronic ischemic heart failure, transendocardial injection of autologous BMCs compared with placebo did not improve LVESV, maximal oxygen consumption, or reversibility on SPECT.
C1 [Lai, Dejian; Baraniuk, Sarah; Piller, Linda B.; Simpson, Lara M.; Bettencourt, Judy; Sayre, Shelly L.; Vojvodic, Rachel W.; Moye, Lemuel A.] Univ Texas Houston, Sch Publ Hlth, Houston, TX 77030 USA.
[Loghin, Catalin] Univ Texas Houston, Sch Med, Houston, TX 77030 USA.
[Penn, Marc S.] NE Ohio Med Univ, Akron, OH USA.
[Anwaruddin, Saif] Univ Penn, Penn Heart & Vasc Hosp, Philadelphia, PA 19104 USA.
[Gee, Adrian P.; Aguilar, David; Richman, Sara] Baylor Univ, Coll Med, Houston, TX 77030 USA.
[Skarlatos, Sonia I.; Gordon, David J.; Ebert, Ray F.; Kwak, Minjung] NHLBI, Bethesda, MD 20892 USA.
[Simari, Robert D.] Mayo Clin, Rochester, MN USA.
[Perin, Emerson C.; Willerson, James T.; Silva, Guilherme V.; Smith, Deirdre; Westbrook, Lynette] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA.
[Pepine, Carl J.; Anderson, R. David; Cogle, Christopher R.; Handberg, Eileen] Univ Florida, Sch Med, Gainesville, FL USA.
[Martin, A. Daniel] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA.
[Henry, Timothy D.; Traverse, Jay H.; Olson, Rachel E.] Abbott NW Hosp, Minneapolis Heart Inst, Minneapolis, MN 55407 USA.
[Henry, Timothy D.; Traverse, Jay H.; Taylor, Doris A.; Zierold, Claudia] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
[Ellis, Stephen G.; Thomas, James D.; Geither, Carrie] Cleveland Clin Fdn, Cleveland, OH 44195 USA.
[Zhao, David X. M.; Kronenberg, Marvin W.; Hatzopoulos, Antonis K.; Bowman, Sherry; Francescon, Judy] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
RP Moye, LA (reprint author), Univ Texas Houston, Sch Publ Hlth, 1200 Pressler,W-848, Houston, TX 77030 USA.
EM lemmoye@msn.com
RI Hatzopoulos, Antonis/D-2049-2010; Cogle, Christopher/H-1746-2016
OI Cogle, Christopher/0000-0001-5422-6863
FU National Heart, Lung, and Blood Institute (NHLBI); Amarin Pharma;
Amorycyte; Angioblast/Mesoblast; Baxter Healthcare; Bayer Healthcare;
Daiichi-Sankyo; GlaxoSmithKline; Lilly; Merck; National Institutes of
Health; National Heart, Lung; Blood Institute; Pfizer; sanofi-aventis;
Viron Therapeutics; Aastrom; Mesoblast; NHLBI [5 U01 HL087318-04,
N01-HB-37164, HHSN268201000008C, N01-HB-37163, HHSN268201000007C];
National Center for Research Resources CTSA [UL1 TR000064]
FX The authors have completed and submitted the ICMJE Form for Disclosure
of Potential Conflicts of Interest. All of the authors reported
receiving research grant funding and support for travel expenses to
meetings for the Cardiovascular Cell Therapy Research Network (CCTRN)
from the National Heart, Lung, and Blood Institute (NHLBI). Dr Perin
reported serving as a consultant to Amorcyte, Teva, Cytori, and Aldagen.
Dr Pepine reported receiving research grants from Amarin Pharma,
Amorycyte, Angioblast/Mesoblast, Baxter Healthcare, Bayer Healthcare,
Daiichi-Sankyo, GlaxoSmithKline, Lilly, Merck, the National Institutes
of Health, the National Heart, Lung, and Blood Institute, Pfizer,
sanofi-aventis, Viron Therapeutics; serving as a consultant to Aastrom,
Amarin Pharma, Amorycyte (scientific advisory board), Angioblast Systems
(data and safety monitoring board), Lilly and County Community
Foundation (data and safety monitoring board), and SLACK Inc; and
holding 2 patents with the University of Florida. Dr Henry reported
serving on steering committees for and receiving research grants from
Aastrom and Mesoblast. Dr Martin reported receiving research grants from
the University of Texas to provide an exercise testing core laboratory
and received financial support for travel expenses. Dr Penn reported
receiving research grants from Athersys Inc; serving as a board member
for Juventas Therapeutics; serving as a consultant to Juventas
Therapeutics and Aastrom Biosciences; and holding patents, receiving
royalties, and owning stock in Juventas Therapeutics. Dr Hatzopoulos
reported receiving payment for lectures from Washington University,
University of Minnesota, and Tennessee State University. Dr Taylor
reported receiving payment for a lecture at an annual meeting of the
Cell Society. Dr Handberg reported receiving grants from Baxter, BDI,
Amrin, Angioblast, Neostem, Harvest Technologies, Daiichi Sankyo,
Pfizer, Gilead Sciences, and GlaxoSmithKline. Ms Olson reported
receiving research grants from Mesoblast and Aastrom. Ms Geither
reported receiving support for travel expenses to meetings from the
Cleveland Clinic. Dr Aguilar reported being a consultant to Amylin
Pharmaceutical in the area of diabetes and heart failure.; Funding for
this trial was provided by the NHLBI under cooperative agreement 5 U01
HL087318-04. It also was supported in part by NHLBI contracts
N01-HB-37164 and HHSN268201000008C awarded to the Molecular and Cellular
Therapeutics Facility, University of Minnesota, and N01-HB-37163 and
HHSN268201000007C awarded to the Cell Processing Facility, Baylor
College of Medicine, and National Center for Research Resources CTSA
grant UL1 TR000064 awarded to the University of Florida. The CCTRN also
acknowledges its industry partners: Biosafe, Biologics Delivery Systems
Group, and Cordis Corporation for their contributions of equipment and
technical support during the conduct of the trial.
NR 42
TC 198
Z9 207
U1 1
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 25
PY 2012
VL 307
IS 16
BP 1717
EP 1726
DI 10.1001/jama.2012.418
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 930OA
UT WOS:000303147500025
PM 22447880
ER
PT J
AU Tao, NJ
Nagahara, L
Thundat, T
Zhang, PM
AF Tao, Nongjian
Nagahara, Larry
Thundat, Thomas
Zhang, Peimeng
TI Biography of Stuart Lindsay
SO JOURNAL OF PHYSICS-CONDENSED MATTER
LA English
DT Biographical-Item
C1 [Tao, Nongjian; Zhang, Peimeng] Arizona State Univ, Tempe, AZ 85287 USA.
[Nagahara, Larry] NCI, Bethesda, MD 20892 USA.
[Thundat, Thomas] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA.
RP Tao, NJ (reprint author), Arizona State Univ, Tempe, AZ 85287 USA.
EM nongjian.tao@asu.edu; nagaharl@mail.nih.gov; thundattg@ornl.gov;
Peiming.Zhang@asu.edu
NR 1
TC 0
Z9 0
U1 1
U2 9
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-8984
J9 J PHYS-CONDENS MAT
JI J. Phys.-Condes. Matter
PD APR 25
PY 2012
VL 24
IS 16
AR 160401
DI 10.1088/0953-8984/24/16/160401
PG 1
WC Physics, Condensed Matter
SC Physics
GA 922PE
UT WOS:000302559200002
PM 22467144
ER
PT J
AU Dirisala, VR
Jeevan, A
Bix, G
Yoshimura, T
McMurray, DN
AF Dirisala, Vijaya R.
Jeevan, Amminikutty
Bix, Gregory
Yoshimura, Teizo
McMurray, David N.
TI Molecular cloning and expression of the IL-10 gene from guinea pigs
SO GENE
LA English
DT Article
DE IL-10 cDNA; Guinea pig; Recombinant protein
ID CLASS-II EXPRESSION; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS;
TOTAL DEFICIENCY; ANIMAL-MODELS; INTERLEUKIN-10; CELLS; CYTOKINES;
DISEASE; NEUTRALIZATION
AB The Guinea pig (Cavia porcellus) is one of the most relevant small animals for modeling human tuberculosis (TB) in terms of susceptibility to low dose aerosol infection, the organization of granulomas, extrapulmonary dissemination and vaccine-induced protection. It is also considered to be a gold standard for a number of other infectious and non-infectious diseases: however, this animal model has a major disadvantage due to the lack of readily available immunological reagents. In the present study, we successfully cloned a cDNA for the critical Th2 cytokine, interleukin-10 (IL-10), from inbred Strain 2 guinea pigs using the DNA sequence information provided by the genome project. The complete open reading frame (ORF) consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10. Surprisingly, it showed only 84% homology with the previously published IL-10 sequence from the C4-deficient (C4D) guinea pig, leading us to clone IL-10 cDNA from the Hartley strain of guinea pig. The IL-10 gene from the Hartley strain showed 100% homology with the IL-10 sequence of Strain 2 guinea pigs. In order to validate the only published IL-10 sequence existing in Genbank reported from C4D guinea pigs, genomic DNA was isolated from tissues of C4D guinea pigs. Amplification with various sets of primers showed that the IL-10 sequence reported from C4D guinea pigs contained numerous errors. Hence the IL-10 sequence that is being reported by us replaces the earlier sequence making our IL-10 sequence to be the first one accurate from guinea pig. Recombinant guinea pig IL-10 proteins were subsequently expressed in both prokaryotic and eukaryotic cells, purified and were confirmed by N-terminal sequencing. Polyclonal anti-IL-10 antibodies were generated in rabbits using the recombinant IL-10 protein expressed in this study. Taken together, our results indicate that the DNA sequence information provided by the genome project is useful to directly clone much needed cDNAs necessary to study TB in the guinea pig. The newly cloned guinea pig IL-10 cDNA and recombinant proteins will serve as valuable resources for immunological studies in the guinea pig model of TB and other diseases. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Dirisala, Vijaya R.; Jeevan, Amminikutty; McMurray, David N.] Texas A&M Hlth Sci Ctr, Dept Microbial & Mol Pathogenesis, Coll Med, College Stn, TX 77843 USA.
[Bix, Gregory] Texas A&M Hlth Sci Ctr, Dept Mol & Cellular Med, Coll Med, College Stn, TX 77843 USA.
[Yoshimura, Teizo] NCI, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.
RP Dirisala, VR (reprint author), Texas A&M Hlth Sci Ctr, Dept Microbial & Mol Pathogenesis, Coll Med, 407 Reynolds Med Bldg, College Stn, TX 77843 USA.
EM dirisala@medicine.tamhsc.edu
RI Dirisala, Vijaya/H-5038-2012; Dirisala, Vijaya/A-2120-2016
FU Colorado State University under NIH [HHSN 266200400091c]
FX This work was supported by a subcontract from Colorado State University
under NIH contract HHSN 266200400091c. The authors thank Dr. Larry
Dangott of the Protein Chemistry Laboratory at Texas A & M University
for successful protein sequencing and Ms. Cathryn Formichella for her
good technical help. We are also very thankful to Dr. Patricia C. Giclas
and her support team from National Jewish Health, Denver, Colorado for
shipping tissues from C4D and C2D guinea pigs.
NR 45
TC 6
Z9 7
U1 1
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD APR 25
PY 2012
VL 498
IS 1
BP 120
EP 127
DI 10.1016/j.gene.2012.01.076
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 923AG
UT WOS:000302589800019
PM 22349028
ER
PT J
AU Belshan, M
Kimata, JT
Brown, C
Cheng, XG
McCulley, A
Larsen, A
Thippeshappa, R
Hodara, V
Giavedoni, L
Hirsch, V
Ratner, L
AF Belshan, Michael
Kimata, Jason T.
Brown, Charles
Cheng, Xiaogang
McCulley, Anna
Larsen, Alison
Thippeshappa, Rajesh
Hodara, Vida
Giavedoni, Luis
Hirsch, Vanessa
Ratner, Lee
TI Vpx is Critical for SIVmne infection of pigtail macaques
SO RETROVIROLOGY
LA English
DT Article
DE Vpx; SIV; Macaques
ID VIRUS TYPE-2 VPX; VIRAL PREINTEGRATION COMPLEX; NUCLEAR-LOCALIZATION
SIGNAL; RESTRICTION FACTOR SAMHD1; CD4(+) T-CELLS; REVERSE
TRANSCRIPTION; NONDIVIDING CELLS; IMMUNODEFICIENCY; REPLICATION; PROTEIN
AB Background: Viral protein X (Vpx) of SIV has been reported to be important for establishing infection in vivo. Vpx has several different activities in vitro, promoting preintegration complex import into the nucleus in quiescent lymphocytes and overcoming a block in reverse transcription in macrophages. Vpx interacts with the DDB1-CUL4-DCAF1 E3 ligase complex, which may or may not be required for the ascribed functions. The goal of the current study was to determine whether these activities of Vpx are important in vivo.
Results: An infectious, pathogenic clone of SIVmne was used to examine correlations between Vpx functions in vitro and in vivo. Three previously described HIV-2 Vpx mutants that were shown to be important for nuclear import of the preintegration complex in quiescent lymphocytes were constructed in SIVmne: A vpx-deleted virus, a truncation of Vpx at amino acid 102 that deletes the C-terminal proline-rich domain (X(102)), and a mutant with tyrosines 66, 69, and 71 changed to alanine (X(y-a)). All mutant viruses replicated similarly to wild type SIVmne027 in primary pigtail macaque PBMCs, and were only slightly retarded in CEMx174 cells. However, all the vpx mutant viruses were defective for replication in both human and pigtail monocyte-derived macrophages. PCR assays demonstrated that the efficiency of reverse transcription and the levels of viral integration in macrophages were substantially reduced for the vpx mutant viruses. In vitro, the X(y-a) mutant, but not the X(102) mutant lost interaction with DCAF1. The wild type SIVmne027 and the three vpx mutant SIVs were inoculated by the intrarectal route into pigtail macaques. Peak levels of plasma viremia of the vpx mutant SIVs were variable, but consistently lower than that observed in macaques infected with wild type SIVmne. In situ hybridization for SIV demonstrated that compared to wild type SIVmne infected macaques five of the six animals inoculated with the vpx mutant SIVs had only low levels of SIV-expressing cells in the rectum, most intestinal epithelial tissues, spleen, and mesenteric and peripheral nodes.
Conclusions: This work demonstrates that the activities of Vpx to overcome restrictions in culture in vitro are also likely to be important for establishment of infection in vivo and suggest that both the nuclear localization and DCAF1-interaction functions of Vpx are critical in vivo.
C1 [Cheng, Xiaogang; McCulley, Anna; Ratner, Lee] Washington Univ, Sch Med, Div Mol Oncol, St Louis, MO 63130 USA.
[Belshan, Michael; Larsen, Alison] Creighton Univ, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA.
[Kimata, Jason T.; Thippeshappa, Rajesh] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA.
[Brown, Charles; Hirsch, Vanessa] NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA.
[Hodara, Vida; Giavedoni, Luis] Texas Biomed Res Inst, SW Natl Primate Res Ctr, Dept Virol & Immunol, San Antonio, TX USA.
[Ratner, Lee] Washington Univ, Div Oncol, St Louis, MO 63110 USA.
RP Ratner, L (reprint author), Washington Univ, Sch Med, Div Mol Oncol, St Louis, MO 63130 USA.
EM lratner@dom.wustl.edu
FU NIAID; Creighton Health Futures Foundation; Nebraska Center for Virology
[RR01635]; Southwest National Primate Research Center [RR13986]; PHS
[AI047725, AI24745, AI55383]
FX We thank Dr. Leland for care of animals, and Ms Campbell for assistance
in processing samples. Funding for SIV RNA levels provided to Advanced
Biosciences Labs through NIAID. This work was supported by Creighton
Health Futures Foundation and Nebraska Center for Virology (RR01635) to
MB, Southwest National Primate Research Center (RR13986), PHS grants
AI047725 to JTK and AI24745 and AI55383 to LR.
NR 42
TC 21
Z9 22
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-4690
J9 RETROVIROLOGY
JI Retrovirology
PD APR 24
PY 2012
VL 9
AR 32
DI 10.1186/1742-4690-9-32
PG 13
WC Virology
SC Virology
GA 947ZY
UT WOS:000304474400001
PM 22531456
ER
PT J
AU Lyko, B
Hammershaimb, EA
Nguitragool, W
Wellems, TE
Desai, SA
AF Lyko, Brian
Hammershaimb, Elizabeth A.
Nguitragool, Wang
Wellems, Thomas E.
Desai, Sanjay A.
TI A high-throughput method to detect Plasmodium falciparum clones in
limiting dilution microplates
SO MALARIA JOURNAL
LA English
DT Article
ID MICROTITER PLATES; PARASITE CLONES; CLONING
AB Background: Molecular and cellular studies of Plasmodium falciparum require cloning of parasites by limiting dilution cultivation, typically performed in microplates. The parasite's slow replication rate combined with laborious methods for identification of positive wells has limited these studies. A new high-throughput method for detecting growth without compromising parasite viability is reported.
Methods: In vitro parasite cultivation is associated with extracellular acidification. A survey of fluorescent pH indicators identified 5-(and-6)-carboxy SNARF-1 as a membrane-impermeant dye with a suitable pK(a) value. Conditions for facile detection of viable parasites in 96-well microplates were optimized and used for limiting dilution cloning of genetic cross progeny and transfected parasites.
Results: 5-(and-6)-carboxy SNARF-1 is a two-emission wavelength dye that accurately reported extracellular pH in parasite cultures. It readily detected parasite growth in microplate wells and yielded results comparable to labour-intensive examination of Giemsa-stained smears. The dye is non-toxic, allowing parasite detection without transfer of culture material to additional plates for separate assays. This dye was used with high-throughput limiting dilution culture to generate additional progeny clones from the HB3 x Dd2 genetic cross.
Conclusions: This fluorescence-based assay represents a low-cost, efficient method for detection of viable parasites in microplate wells; it can be easily expanded by automation.
C1 [Lyko, Brian; Hammershaimb, Elizabeth A.; Nguitragool, Wang; Wellems, Thomas E.; Desai, Sanjay A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
[Nguitragool, Wang] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
RP Desai, SA (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Room 3W-01,12735 Twinbrook Pkwy, Rockville, MD 20852 USA.
EM sdesai@niaid.nih.gov
FU National Institutes of Health, National Institute of Allergy and
Infectious Diseases
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Allergy and
Infectious Diseases.
NR 9
TC 11
Z9 11
U1 2
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD APR 24
PY 2012
VL 11
AR 124
DI 10.1186/1475-2875-11-124
PG 5
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 942LZ
UT WOS:000304046800001
PM 22531353
ER
PT J
AU Matsuoka, T
Yashiro, M
Nishioka, N
Hirakawa, K
Olden, K
Roberts, J
AF Matsuoka, T.
Yashiro, M.
Nishioka, N.
Hirakawa, K.
Olden, K.
Roberts, J. D.
TI PI3K/Akt signalling is required for the attachment and spreading, and
growth in vivo of metastatic scirrhous gastric carcinoma
SO BRITISH JOURNAL OF CANCER
LA English
DT Article
DE PI3 kinase; gastric carcinoma; adhesion; spreading; metastasis; integrin
signalling
ID FOCAL ADHESION KINASE; HUMAN CANCER; PHOSPHATIDYLINOSITOL 3-KINASE;
PHOSPHOINOSITIDE 3-KINASE; STRUCTURAL BASIS; CELL-MIGRATION; SRC;
PATHWAY; FAMILY; ACTIVATION
AB BACKGROUND: PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined.
METHODS: The role of the PI3K/Akt pathway in an extensive peritoneal-seeding cell line, OCUM-2MD3 and a parental cell line, OCUM-2M, was investigated by assessing in vitro adhesion and spreading assay, and in vivo peritoneal metastatic model. We also examined the correlation of PI3K/Akt pathway with integrin signals by immunoprecipitations, using cells by transfection with mutant p85 (Delta p85).
RESULTS: Adhesiveness and spreading of OCUM-2MD3 cells on collagen type IV was significantly decreased by PI3K inhibitors and expression of mutant p85, but not by inhibitors of protein kinase C (PKC) or extracellular signal-regulated kinase (ERK). Immunoprecipitation studies indicated that the PI3K/Akt pathway was associated with integrin signalling through Src and vinculin. In an in vivo experimental metastasis model, p85 inhibition reduced peritoneal metastasis of OCUM-2MD3 cells.
CONCLUSION: PI3K/Akt signalling may be required for integrin-dependent attachment and spreading of scirrhous gastric carcinoma cells, and would be translated into generating better strategies to optimise their use in cancer clinical trials. British Journal of Cancer (2012) 106, 1535-1542. doi:10.1038/bjc.2012.107 www.bjcancer.com (C) 2012 Cancer Research UK
C1 [Matsuoka, T.; Nishioka, N.; Olden, K.; Roberts, J. D.] NIEHS, US Dept HHS, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Matsuoka, T.; Yashiro, M.; Nishioka, N.; Hirakawa, K.] Osaka City Univ, Dept Surg Oncol, Grad Sch Med, Osaka 558, Japan.
RP Matsuoka, T (reprint author), NIEHS, US Dept HHS, Mol Carcinogenesis Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM matsuoka@med.osaka-cu.ac.jp
FU NIH; NIEHS
FX We thank Dr Wataru Ogawa for providing wild-type and mutant p85
expression plasmids under the control of the SR promoter. We thank Dr
Steven K. Akiyama for helpful discussions, and Dr Ron Cannon and Dr
Richard DiAugustine of NIEHS for a careful review of the manuscript.
This work was supported by the Intramural Research Program of the NIH
and NIEHS.
NR 43
TC 9
Z9 11
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0007-0920
J9 BRIT J CANCER
JI Br. J. Cancer
PD APR 24
PY 2012
VL 106
IS 9
BP 1535
EP 1542
DI 10.1038/bjc.2012.107
PG 8
WC Oncology
SC Oncology
GA 933SR
UT WOS:000303383500012
PM 22531720
ER
PT J
AU Masison, DC
AF Masison, Daniel C.
TI Perfecting precision of predicting prion propensity
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Editorial Material
ID BETA-SHEET STRUCTURE; FORM PRIONS; PROTEIN; AGGREGATION; SEQUENCE;
DOMAINS; FIBRILS; REGIONS; YEAST
C1 NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA.
RP Masison, DC (reprint author), NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA.
EM masisond@helix.nih.gov
FU Intramural NIH HHS
NR 20
TC 0
Z9 0
U1 0
U2 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 24
PY 2012
VL 109
IS 17
BP 6362
EP 6363
DI 10.1073/pnas.1203767109
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931WD
UT WOS:000303249100014
PM 22499791
ER
PT J
AU Ma, WJ
Halweg, CJ
Menendez, D
Resnick, MA
AF Ma, Wenjian
Halweg, Christopher J.
Menendez, Daniel
Resnick, Michael A.
TI Differential effects of poly(ADP-ribose) polymerase inhibition on DNA
break repair in human cells are revealed with Epstein-Barr virus
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE base excision repair; BRCA
ID DOUBLE-STRAND BREAKS; BASE EXCISION-REPAIR; FIELD GEL-ELECTROPHORESIS;
ADP-RIBOSE POLYMERASE; WILD-TYPE P53; SINGLE-STRAND; PARP INHIBITION;
COMET ASSAY; SV40 DNA; RADIATION
AB Poly(ADP-ribose) polymerase (PARP) inhibitors can generate synthetic lethality in cancer cells defective in homologous recombination. However, the mechanism(s) by which they affect DNA repair has not been established. Here we directly determined the effects of PARP inhibition and PARP1 depletion on the repair of ionizing radiation-induced single-and double-strand breaks (SSBs and DSBs) in human lymphoid cell lines. To do this, we developed an in vivo repair assay based on large endogenous Epstein-Barr virus (EBV) circular episomes. The EBV break assay provides the opportunity to assess quantitatively and simultaneously the induction and repair of SSBs and DSBs in human cells. Repair was efficient in G1 and G2 cells and was not dependent on functional p53. shRNA-mediated knockdown of PARP1 demonstrated that the PARP1 protein was not essential for SSB repair. Among 10 widely used PARP inhibitors, none affected DSB repair, although an inhibitor of DNA-dependent protein kinase was highly effective at reducing DSB repair. Only Olaparib and Iniparib, which are in clinical cancer therapy trials, as well as 4-AN inhibited SSB repair. However, a decrease in PARP1 expression reversed the ability of Iniparib to reduce SSB repair. Because Iniparib disrupts PARP1-DNA binding, the mechanism of inhibition does not appear to involve trapping PARP at SSBs.
C1 [Ma, Wenjian; Halweg, Christopher J.; Menendez, Daniel; Resnick, Michael A.] NIEHS, Chromosome Stabil Sect, NIH, Res Triangle Pk, NC 27709 USA.
RP Resnick, MA (reprint author), NIEHS, Chromosome Stabil Sect, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM resnick@niehs.nih.gov
FU NIEHS (National Institutes of Health, Department of Health and Human
Services) [1 Z01 ES065073]
FX We thank Dr. Norman Sharpless, Dr. Julie Horton, Dr. Michelle Heacock,
Dr. Kin Chan, and Jim Westmoreland for critical reading of the
manuscript, and Dr. Charles Romeo and Dr. Negin Martin at the National
Institute of Environmental Health Sciences (NIEHS) Viral Vector Core
Laboratory for generating LCL35 shRNA cell lines. This work was
supported by the Intramural Research Program of the NIEHS (National
Institutes of Health, Department of Health and Human Services) under
Project 1 Z01 ES065073 (to M.A.R.).
NR 64
TC 17
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U1 0
U2 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 24
PY 2012
VL 109
IS 17
BP 6590
EP 6595
DI 10.1073/pnas.1118078109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931WD
UT WOS:000303249100053
PM 22493268
ER
PT J
AU Arredondo, SA
Cai, ML
Takayama, Y
MacDonald, NJ
Anderson, DE
Aravind, L
Clore, GM
Miller, LH
AF Arredondo, Silvia A.
Cai, Mengli
Takayama, Yuki
MacDonald, Nicholas J.
Anderson, D. Eric
Aravind, L.
Clore, G. Marius
Miller, Louis H.
TI Structure of the Plasmodium 6-cysteine s48/45 domain
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE Plasmodium domain evolution; Escherichia coli periplasmic expression;
solution conformation
ID TRANSMISSION-BLOCKING IMMUNITY; GAMETE-SURFACE PROTEIN;
TOXOPLASMA-GONDII; COMPARATIVE GENOMICS; BALANCING SELECTION; VACCINE
CANDIDATE; ESCHERICHIA-COLI; SRS SUPERFAMILY; NMR STRUCTURE; HOST-CELLS
AB The s48/45 domain was first noted in Plasmodium proteins more than 15 y ago. Previously believed to be unique to Plasmodium, the s48/45 domain is present in other aconoidasidans. In Plasmodium, members of the s48/45 family of proteins are localized on the surface of the parasite in different stages, mostly by glycosylphosphatydylinositol-anchoring. Members such as P52 and P36 seem to play a role in invasion of hepatocytes, and Pfs230 and Pfs48/45 are involved in fertilization in the sexual stages and have been consistently studied as targets of transmission-blocking vaccines for years. In this report, we present the molecular structure for the s48/45 domain corresponding to the C-terminal domain of the blood-stage protein Pf12 from Plasmodium falciparum, obtained by NMR. Our results indicate that this domain is a beta-sandwich formed by two sheets with a mixture of parallel and antiparallel strands. Of the six conserved cysteines, two pairs link the beta-sheets by two disulfide bonds, and the third pair forms a bond outside the core. The structure of the s48/45 domain conforms well to the previously defined surface antigen 1 (SAG1)-related-sequence (SRS) fold observed in the SAG family of surface antigens found in Toxoplasma gondii. Despite extreme sequence divergence, remarkable spatial conservation of one of the disulfide bonds is observed, supporting the hypothesis that the domains have evolved from a common ancestor. Furthermore, a homologous domain is present in ephrins, raising the possibility that the precursor of the s48/45 and SRS domains emerged from an ancient transfer to Apicomplexa from metazoan hosts.
C1 [Aravind, L.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
[Arredondo, Silvia A.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
[MacDonald, Nicholas J.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD 20852 USA.
[Miller, Louis H.] NIAID, Lab Malaria Vector Res, NIH, Rockville, MD 20852 USA.
[Cai, Mengli; Takayama, Yuki; Clore, G. Marius] NIDDKD, Chem Phys Lab, NIH, Bethesda, MD 20892 USA.
[Anderson, D. Eric] NIDDKD, Mass Spectrometry Facil, NIH, Bethesda, MD 20892 USA.
RP Aravind, L (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
EM aravind@mail.nih.gov; mariusc@intra.niddk.nih.gov; lmiller@niaid.nih.gov
RI Clore, G. Marius/A-3511-2008
OI Clore, G. Marius/0000-0003-3809-1027
FU National Library of Medicine; National Institute of Allergy and
Infectious Diseases; National Institute of Diabetes and Digestive and
Kidney Diseases of the National Institutes of Health
FX We thank Susan Pierce (Laboratory of Immunogenetics) and Kim Williamson
and Prakash Srinivasan (Laboratory of Malaria Vector Research) for very
insightful discussions. This work was supported by the intramural funds
from the National Library of Medicine (to L.A.), the National Institute
of Allergy and Infectious Diseases (L.H.M.), and the National Institute
of Diabetes and Digestive and Kidney Diseases (G.M.C.) of the National
Institutes of Health.
NR 65
TC 28
Z9 30
U1 0
U2 2
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 24
PY 2012
VL 109
IS 17
BP 6692
EP 6697
DI 10.1073/pnas.1204363109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931WD
UT WOS:000303249100070
PM 22493233
ER
PT J
AU Buyske, S
Wu, Y
Carty, CL
Cheng, IN
Assimes, TL
Dumitrescu, L
Hindorff, LA
Mitchell, S
Ambite, JL
Boerwinkle, E
Buzkova, P
Carlson, CS
Cochran, B
Duggan, D
Eaton, CB
Fesinmeyer, MD
Franceschini, N
Haessler, J
Jenny, N
Kang, HM
Kooperberg, C
Lin, Y
Le Marchand, L
Matise, TC
Robinson, JG
Rodriguez, C
Schumacher, FR
Voight, BF
Young, A
Manolio, TA
Mohlke, KL
Haiman, CA
Peters, U
Crawford, DC
North, KE
AF Buyske, Steven
Wu, Ying
Carty, Cara L.
Cheng, Iona
Assimes, Themistocles L.
Dumitrescu, Logan
Hindorff, Lucia A.
Mitchell, Sabrina
Ambite, Jose Luis
Boerwinkle, Eric
Buzkova, Petra
Carlson, Chris S.
Cochran, Barbara
Duggan, David
Eaton, Charles B.
Fesinmeyer, Megan D.
Franceschini, Nora
Haessler, Jeffrey
Jenny, Nancy
Kang, Hyun Min
Kooperberg, Charles
Lin, Yi
Le Marchand, Loic
Matise, Tara C.
Robinson, Jennifer G.
Rodriguez, Carlos
Schumacher, Fredrick R.
Voight, Benjamin F.
Young, Alicia
Manolio, Teri A.
Mohlke, Karen L.
Haiman, Christopher A.
Peters, Ulrike
Crawford, Dana C.
North, Kari E.
TI Evaluation of the Metabochip Genotyping Array in African Americans and
Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
SO PLOS ONE
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; DENSITY-LIPOPROTEIN CHOLESTEROL; POPULATION;
COMMON; SNPS; IMPUTATION; VARIANT; DESIGN; TOOL; MAP
AB The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all SNPs passed rigorous quality control with a call rate of 99.9%. Two examples illustrate the value of fine mapping with the Metabochip in African-ancestry populations. At CELSR2/PSRC1/SORT1, we found the strongest associated SNP for LDL-C to be rs12740374 (p = 3.5x10(-11)), a SNP indistinguishable from multiple SNPs in European ancestry samples due to high correlation. Its distinct signal supports functional studies elsewhere suggesting a causal role in LDL-C. At CETP we found rs17231520, with risk allele frequency 0.07 in African Americans, to be associated with HDL-C (p = 7.2x10(-36)). This variant is very rare in Europeans and not tagged in common GWAS arrays, but was identified as associated with HDL-C in African Americans in a single-gene study. Our results, one narrowing the risk interval and the other revealing an associated variant not found in Europeans, demonstrate the advantages of high-density genotyping of common and rare variation for fine mapping of trait loci in African American samples.
C1 [Buyske, Steven] Rutgers State Univ, Dept Stat & Biostat, Piscataway, NJ 08855 USA.
[Wu, Ying; Mohlke, Karen L.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Carty, Cara L.; Carlson, Chris S.; Fesinmeyer, Megan D.; Haessler, Jeffrey; Kooperberg, Charles; Lin, Yi; Young, Alicia; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Cheng, Iona; Le Marchand, Loic] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
[Assimes, Themistocles L.] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
[Dumitrescu, Logan; Crawford, Dana C.] Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA.
[Hindorff, Lucia A.; Manolio, Teri A.] NHGRI, Off Populat Genom, NIH, Bethesda, MD 20892 USA.
[Mitchell, Sabrina; Crawford, Dana C.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
[Ambite, Jose Luis] Univ So Calif, Inst Informat Sci, Los Angeles, CA USA.
[Boerwinkle, Eric] Univ Texas Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA.
[Buzkova, Petra] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Cochran, Barbara] Baylor Coll Med, Sponsored Programs, Houston, TX 77030 USA.
[Duggan, David] Translat Genom Res Inst, Phoenix, AZ USA.
[Eaton, Charles B.] Brown Univ, Ctr Primary Care & Prevent, Dept Family Med & Epidemiol, Alpert Med Sch, Providence, RI 02912 USA.
[Franceschini, Nora; North, Kari E.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Jenny, Nancy] Univ Vermont, Dept Pathol, Burlington, VT 05405 USA.
[Kang, Hyun Min] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
[Buyske, Steven; Matise, Tara C.] Rutgers State Univ, Dept Genet, Piscataway, NJ USA.
[Robinson, Jennifer G.] Univ Iowa, Dept Epidemiol & Med, Iowa City, IA USA.
[Rodriguez, Carlos] Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA.
[Schumacher, Fredrick R.; Haiman, Christopher A.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
[Voight, Benjamin F.] Broad Inst Harvard & MIT, Cambridge, MA USA.
[Mohlke, Karen L.; North, Kari E.] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.
RP Buyske, S (reprint author), Rutgers State Univ, Dept Stat & Biostat, Piscataway, NJ 08855 USA.
EM kari_north@unc.edu
RI Carty, Cara/B-8683-2013; Crawford, Dana/C-1054-2012;
OI Buyske, Steven/0000-0001-8539-5416
FU National Human Genome Research Institute (NHGRI) [U01HG004803,
U01HG004798, U01HG004802, U01HG004790, U01HG004801]; NHLBI
[N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020,
N01-HC-55021, N01-HC-55022]; National Cancer Institute [R37CA54281, R01
CA63, P01CA33619, U01CA136792, U01CA98758]; National Heart, Lung, and
Blood Institute (NHLBI) (NIH); U.S. Department of Health and Human
Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115,
32118-32119, 32122, 42107-26, 42129-32, 44221]; National Institutes of
Mental Health
FX The Population Architecture Using Genomics and Epidemiology (PAGE)
program is funded by the National Human Genome Research Institute
(NHGRI), supported by U01HG004803 (Causal Variants Across the Life
Course, known as CALiCo), U01HG004798 (Epidemiologic Architecture of
Genes Linked to Environment, known as EAGLE), U01HG004802 (the
Multiethnic Cohort, known as MEC), U01HG004790 (Women's Health
Initiative, known as WHI), and U01HG004801 (Coordinating Center). The
Atherosclerosis Risk in Communities (ARIC) Study is carried out as a
collaborative study supported by NHLBI contracts N01-HC-55015,
N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021,
N01-HC-55022. The Multiethnic Cohort (MEC) study is funded through the
National Cancer Institute (R37CA54281, R01 CA63, P01CA33619,
U01CA136792, and U01CA98758). The Women's Health Initiative (WHI)
program is funded by the National Heart, Lung, and Blood Institute
(NHLBI) (NIH) and by U.S. Department of Health and Human Services
through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9,
32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. The
National Institutes of Mental Health also contributes to the support for
the Coordinating Center. NHGRI collaborators (LAH and TAM) assisted in
the study design, analysis, and preparation of the manuscript.
NR 38
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U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 23
PY 2012
VL 7
IS 4
AR e35651
DI 10.1371/journal.pone.0035651
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UP
UT WOS:000305341000054
PM 22539988
ER
PT J
AU Pomerantz, O
Paukner, A
Terkel, J
AF Pomerantz, Ori
Paukner, Annika
Terkel, Joseph
TI Some stereotypic behaviors in rhesus macaques (Macaca mulatta) are
correlated with both perseveration and the ability to cope with acute
stressors
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Stereotypic behavior; Perseveration; Coping hypothesis; Basal ganglia;
Psychological welfare
ID ABNORMAL REPETITIVE BEHAVIORS; SELF-INJURIOUS-BEHAVIOR; BASAL GANGLIA;
COPING RESPONSE; LABORATORY MICE; MONKEYS; SCHIZOPHRENIA; DISINHIBITION;
PHYSIOLOGY; ANIMALS
AB The most prevalent sub-group of abnormal repetitive behaviors among captive animals is that of stereotypies. Previous studies have demonstrated some resemblance between stereotypy in captive animals and in humans, including the involvement of neurological malfunctions that lead to the expression of stereotypies. This malfunction can be evaluated through the use of neuropsychological tasks that assess perseveration as implying a failure of the basal ganglia (BC) to operate properly. Other studies, in contrast, have suggested that stereotypies are the product of neurologically intact individuals reacting to the abnormal nature of their surroundings, and are possibly characterized by an adaptive feature that enables the subject to cope with such adversity. Employing neuropsychological tests and also measuring the levels of fecal corticoids in captive rhesus macaques, we tested the hypothesis that stereotypies are related both to brain pathology and to a coping mechanism with stress, resembling accounts by autistic individuals exhibiting basal ganglia malfunction, and who report a sense of relief when performing stereotypies. Self-directed and fine-motor stereotypies exhibited by the monkeys were positively correlated with perseveration, Suggesting BG malfunction; while self-directed stereotypies were also negatively correlated with an increase in fecal corticoids following a stress challenge, suggesting a related coping mechanism. We therefore suggest that not all repetitive, unvarying, and apparently functionless behaviors should be regarded as one homogeneous group of stereotypic behaviors; and that, reflecting reports from autistic individuals, self-directed stereotypies in captive rhesus monkeys are related both to brain pathology, and to an adaptive mechanism that allows those that express them to better cope with acute stressors. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Pomerantz, Ori; Terkel, Joseph] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel.
[Paukner, Annika] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Comparat Ethol Lab, NIH, Anim Ctr, Poolesville, MD 20837 USA.
RP Pomerantz, O (reprint author), Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel.
EM oripomer@post.tau.ac.il
RI Pomerantz, Ori/B-1869-2013
FU Intramural NIH HHS [Z99 HD999999]
NR 51
TC 11
Z9 11
U1 1
U2 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 21
PY 2012
VL 230
IS 1
BP 274
EP 280
DI 10.1016/j.bbr.2012.02.019
PG 7
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 973SJ
UT WOS:000306379800033
PM 22366267
ER
PT J
AU Fitzgerald, PJ
AF Fitzgerald, Paul J.
TI The NMDA receptor may participate in widespread suppression of circuit
level neural activity, in addition to a similarly prominent role in
circuit level activation
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Review
DE Glutamate; NMDA receptor; Epilepsy; Neurotoxicity; Knockout mouse;
Electrophysiology; 2-Deoxyglucose; Functional brain imaging; Ketamine;
Phencyclidine; MK-801
ID METHYL-D-ASPARTATE; BRAIN METABOLIC-ACTIVATION; MICE LACKING; PREFRONTAL
CORTEX; PREPULSE INHIBITION; POTENTIAL RELEVANCE; DOPAMINE NEURONS;
BLOOD-FLOW; RAT-BRAIN; 2-DEOXYGLUCOSE UPTAKE
AB The N-methyl-D-aspartate receptor (NMDAR) plays a critical role in glutamatergically mediated neurotransmission, and thereby affects a wide range of brain circuits and important behavioral functions, not limited to learning and memory. While glutamate is classically considered to be the brain's principal excitatory neurotransmitter, there is also evidence the NMDAR plays a "functionally inhibitory" role, not in that it directly hyperpolarizes neurons but rather it suppresses circuit level neural activity, including through activation of GABAergic interneurons. This paper reviews data on the NMDAR "suppression" hypothesis (while also examining circuit level activation), with a focus on the following 6 lines of evidence: (1) epilepsy studies, (2) neurotoxicity studies, (3) mouse knockout studies of particular receptor subunits, (4) electrophysiological studies, (5) 2-deoxyglucose studies, and (6) functional brain imaging studies. For many of these lines of evidence, the review focuses on data from two well-characterized NMDAR antagonists, ketamine and phencyclidine. Also, evidence regarding the NMDAR and schizophrenia, including the psychotomimetic properties of ketamine and phencyclidine, cuts across several of the lines of evidence. The data suggest the NMDAR participates in activation, as well as widespread suppression, of circuit level neural activity, where the suppression may be particularly prominent in limbic circuits. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Fitzgerald, Paul J.] Johns Hopkins Univ, Zanvyl Krieger Mind Brain Inst, Solomon H Snyder Dept Neurosci, Baltimore, MD 21218 USA.
RP Fitzgerald, PJ (reprint author), NIAAA, 5625 Fishers Lane,Room 2N09, Rockville, MD 20852 USA.
EM pfitz@mbi.mb.jhu.edu
NR 110
TC 13
Z9 14
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 21
PY 2012
VL 230
IS 1
BP 291
EP 298
DI 10.1016/j.bbr.2012.01.057
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 973SJ
UT WOS:000306379800036
PM 22342923
ER
PT J
AU Chowell, G
Viboud, C
Simonsen, L
Miller, MA
Echevarria-Zuno, S
Gonzalez-Leon, M
Aburto, VHB
AF Chowell, Gerardo
Viboud, Cecile
Simonsen, Lone
Miller, Mark A.
Echevarria-Zuno, Santiago
Gonzalez-Leon, Margot
Aburto, Victor H. Borja
TI Impact of antiviral treatment and hospital admission delay on risk of
death associated with 2009 A/H1N1 pandemic influenza in Mexico
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE 2009 A/H1N1 influenza pandemic; Neuraminidase inhibitors; Antivirals;
Case fatality ratio; Multivariate logistic regression; Hospital
admission delay; Pandemic wave; Mexico
ID A H1N1 VIRUS; OSELTAMIVIR TREATMENT; ILL PATIENTS; INFECTION; CHILDREN;
MORTALITY; SEVERITY; OUTCOMES; A(H1N1); CHILE
AB Background: Increasing our understanding of the factors affecting the severity of the 2009 A/H1N1 influenza pandemic in different regions of the world could lead to improved clinical practice and mitigation strategies for future influenza pandemics. Even though a number of studies have shed light into the risk factors associated with severe outcomes of 2009 A/H1N1 influenza infections in different populations (e.g., [1-5]), analyses of the determinants of mortality risk spanning multiple pandemic waves and geographic regions are scarce. Between-country differences in the mortality burden of the 2009 pandemic could be linked to differences in influenza case management, underlying population health, or intrinsic differences in disease transmission [6]. Additional studies elucidating the determinants of disease severity globally are warranted to guide prevention efforts in future influenza pandemics. In Mexico, the 2009 A/H1N1 influenza pandemic was characterized by a three-wave pattern occurring in the spring, summer, and fall of 2009 with substantial geographical heterogeneity [7]. A recent study suggests that Mexico experienced high excess mortality burden during the 2009 A/H1N1 influenza pandemic relative to other countries [6]. However, an assessment of potential factors that contributed to the relatively high pandemic death toll in Mexico are lacking. Here, we fill this gap by analyzing a large series of laboratory-confirmed A/H1N1 influenza cases, hospitalizations, and deaths monitored by the Mexican Social Security medical system during April 1 through December 31, 2009 in Mexico. In particular, we quantify the association between disease severity, hospital admission delays, and neuraminidase inhibitor use by demographic characteristics, pandemic wave, and geographic regions of Mexico.
Methods: We analyzed a large series of laboratory-confirmed pandemic A/H1N1 influenza cases from a prospective surveillance system maintained by the Mexican Social Security system, April-December 2009. We considered a spectrum of disease severity encompassing outpatient visits, hospitalizations, and deaths, and recorded demographic and geographic information on individual patients. We assessed the impact of neuraminidase inhibitor treatment and hospital admission delay (<= > 2 days after disease onset) on the risk of death by multivariate logistic regression.
Results: Approximately 50% of all A/H1N1-positive patients received antiviral medication during the Spring and Summer 2009 pandemic waves in Mexico while only 9% of A/H1N1 cases received antiviral medications during the fall wave (P < 0.0001). After adjustment for age, gender, and geography, antiviral treatment significantly reduced the risk of death (OR = 0.52 (95% CI: 0.30, 0.90)) while longer hospital admission delays increased the risk of death by 2.8-fold (95% CI: 2.25, 3.41).
Conclusions: Our findings underscore the potential impact of decreasing admission delays and increasing antiviral use to mitigate the mortality burden of future influenza pandemics.
C1 [Chowell, Gerardo] Arizona State Univ, Sch Human Evolut & Social Change, Math Computat & Modeling Sci Ctr, Tempe, AZ 85069 USA.
[Simonsen, Lone] George Washington Univ, Sch Publ Hlth, Dept Global Hlth, Washington, DC USA.
[Simonsen, Lone] George Washington Univ, Hlth Serv, Washington, DC USA.
[Echevarria-Zuno, Santiago] Inst Mexicano Seguro Social, Direcc Prestaciones Med, Mexico City 03100, DF, Mexico.
[Chowell, Gerardo] Arizona State Univ, Div Epidemiol & Populat Studies, Fogarty Int Ctr, NIH,Sch Human Evolut & Social Change, Tempe, AZ USA.
RP Chowell, G (reprint author), Arizona State Univ, Sch Human Evolut & Social Change, Math Computat & Modeling Sci Ctr, Tempe, AZ 85069 USA.
EM gchowell@asu.edu
RI Chowell, Gerardo/F-5038-2012;
OI Chowell, Gerardo/0000-0003-2194-2251; Simonsen, Lone/0000-0003-1535-8526
FU International Influenza Unit, Office of Global Health Affairs,
Department of Health and Human Services; RAPIDD program of the Science
and Technology Directorate; Department of Homeland Security; Fogarty
International Center
FX This research was conducted in the context of the MISMS Study, an
ongoing international collaborative effort to understand influenza
epidemiological and evolutionary patterns, led by the Fogarty
International Center, National Institutes of Health
(http://www.origem.info/misms/index.php). The MISMS study is funded by
the International Influenza Unit, Office of Global Health Affairs,
Department of Health and Human Services. LS acknowledges support from
the RAPIDD program of the Science and Technology Directorate, Department
of Homeland Security, and the Fogarty International Center.
NR 51
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Z9 6
U1 0
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD APR 20
PY 2012
VL 12
AR 97
DI 10.1186/1471-2334-12-97
PG 11
WC Infectious Diseases
SC Infectious Diseases
GA 009DZ
UT WOS:000309007100001
PM 22520743
ER
PT J
AU Minguzzi, S
Molloy, AM
Peadar, K
Mills, J
Scott, JM
Troendle, J
Pangilinan, F
Brody, L
Parle-McDermott, A
AF Minguzzi, Stefano
Molloy, Anne M.
Peadar, Kirke
Mills, James
Scott, John M.
Troendle, James
Pangilinan, Faith
Brody, Lawrence
Parle-McDermott, Anne
TI Genotyping of a tri-allelic polymorphism by a novel melting curve assay
in MTHFD1L: an association study of nonsyndromic Cleft in Ireland
SO BMC MEDICAL GENETICS
LA English
DT Article
ID MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE; NEURAL-TUBE DEFECTS;
OROFACIAL CLEFTS; RISK-FACTOR; FOLIC-ACID; GENE POLYMORPHISMS;
MESSENGER-RNA; FOLATE INTAKE; LIP; PALATE
AB Background: Polymorphisms within the MTHFD1L gene were previously associated with risk of neural tube defects in Ireland. We sought to test the most significant MTHFD1L polymorphisms for an association with risk of cleft in an Irish cohort. This required the development of a new melting curve assay to genotype the technically challenging MTHFD1L triallelic deletion/insertion polymorphism (rs3832406).
Methods: Melting curve analysis was used to genotype the MTHFD1L triallelic deletion/insertion polymorphism (rs3832406) and a Single Nucleotide Polymorphism rs17080476 in an Irish cohort consisting of 981 Irish case-parent trios and 1,008 controls. Tests for association with nonsyndromic cleft lip with or without cleft palate and cleft palate included case/control analysis, mother/control analysis and Transmission Disequilibrium Tests of case-parent trios.
Results: A successful melting curve genotyping assay was developed for the deletion/insertion polymorphism (rs3832406). The TDT analysis initially showed that the rs3832406 polymorphism was associated with isolated cleft lip with or without cleft palate. However, corrected p-values indicated that this association was not significant.
Conclusions: Melting Curve Analysis can be employed to successfully genotype challenging polymorphisms such as the MTHFD1L triallelic deletion/insertion polymorphism (DIP) reported here (rs3832406) and is a viable alternative to capillary electrophoresis. Corrected p-values indicate no association between MTHFD1L and risk of cleft in an Irish cohort.
C1 [Minguzzi, Stefano; Parle-McDermott, Anne] Dublin City Univ, Sch Biotechnol, Nutr Genom Grp, Dublin 9, Ireland.
[Molloy, Anne M.] Univ Dublin Trinity Coll, Sch Med, Dublin 2, Ireland.
[Peadar, Kirke] Hlth Res Board, Child Hlth Epidemiol Unit, Dublin, Ireland.
[Mills, James; Troendle, James] Eunice Kennedy Shriver Natl Inst Hlth, Dept Hlth & Human Serv, Bethesda, MD USA.
[Scott, John M.] Univ Dublin Trinity Coll, Sch Immunol & Biochem, Dublin 2, Ireland.
[Pangilinan, Faith; Brody, Lawrence] NHGRI, Mol Pathogenesis Sect, Genome Technol Branch, Bethesda, MD 20892 USA.
RP Parle-McDermott, A (reprint author), Dublin City Univ, Sch Biotechnol, Nutr Genom Grp, Dublin 9, Ireland.
EM anne.parle-mcdermott@dcu.ie
OI Molloy, Anne/0000-0002-1688-9049
FU IRCSET Embark initiative; Intramural Research Program of the Eunice
Kennedy Shriver National Institute of Child Health and Human
Development; Health Research Board of Ireland
FX This work was supported by the IRCSET Embark initiative. The authors
sincerely thank all the patients and families who participated in the
study, the Cleft Lip and Palate Association of Ireland, and the Dublin
Cleft Centre team. Recruitment of the Irish cleft cohort was supported
by the Intramural Research Program of the Eunice Kennedy Shriver
National Institute of Child Health and Human Development and the Health
Research Board of Ireland.
NR 30
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U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD APR 20
PY 2012
VL 13
AR 29
DI 10.1186/1471-2350-13-29
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 994VE
UT WOS:000307961000001
PM 22520921
ER
PT J
AU Jeang, KT
AF Jeang, Kuan-Teh
TI Epidermal growth factor receptor (EGFR) biology and Wnt developmental
signaling highlight research endeavors of SCBA award winners
SO CELL AND BIOSCIENCE
LA English
DT Article
AB This month's Cell and Bioscience highlights review articles by Mien-Chie Hung on EGFR biology and Yingzi Yang on Wnt signaling. Dr. Hung was the 2011 Society of Chinese Bioscientists in America (SCBA) Presidential Award winner. Dr. Yang was the 2011 SCBA Outstanding Young Investigator Award winner.
C1 NIAID, Bethesda, MD 20892 USA.
RP Jeang, KT (reprint author), NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM kjeang@niaid.nih.gov
FU National Institute of Allergy and Infectious Diseases
FX I thank Yun-Bo Shi for asking me to write this brief commentary. Work in
my laboratory is supported in part by intramural funding from the
National Institute of Allergy and Infectious Diseases. This commentary
is my personal opinion and does not necessarily represent the views of
my employer, the National Institutes of Health, USA.
NR 3
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Z9 0
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD APR 20
PY 2012
VL 2
AR 12
DI 10.1186/2045-3701-2-12
PG 2
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 988SV
UT WOS:000307511900001
PM 22520574
ER
PT J
AU Cowan, RE
Fregly, BJ
Boninger, ML
Chan, L
Rodgers, MM
Reinkensmeyer, DJ
AF Cowan, Rachel E.
Fregly, Benjamin J.
Boninger, Michael L.
Chan, Leighton
Rodgers, Mary M.
Reinkensmeyer, David J.
TI Recent trends in assistive technology for mobility
SO JOURNAL OF NEUROENGINEERING AND REHABILITATION
LA English
DT Review
DE Disability; Assistive technology; Robotics
ID ANKLE-FOOT ORTHOSIS; SYSTEM; PROSTHETICS; WHEELCHAIR; VISION; DESIGN;
INJURY; GAIT
AB Loss of physical mobility makes maximal participation in desired activities more difficult and in the worst case fully prevents participation. This paper surveys recent work in assistive technology to improve mobility for persons with a disability, drawing on examples observed during a tour of academic and industrial research sites in Europe. The underlying theme of this recent work is a more seamless integration of the capabilities of the user and the assistive technology. This improved integration spans diverse technologies, including powered wheelchairs, prosthetic limbs, functional electrical stimulation, and wearable exoskeletons. Improved integration is being accomplished in three ways: 1) improving the assistive technology mechanics; 2) improving the user-technology physical interface; and 3) sharing of control between the user and the technology. We provide an overview of these improvements in user-technology integration and discuss whether such improvements have the potential to be transformative for people with mobility impairments.
C1 [Cowan, Rachel E.] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Fregly, Benjamin J.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Boninger, Michael L.] Univ Pittsburgh, Dept Phys Med & Rehabil, Sch Med, Pittsburgh, PA 15260 USA.
[Chan, Leighton] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
[Rodgers, Mary M.] Univ Maryland, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA.
[Rodgers, Mary M.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA.
[Reinkensmeyer, David J.] Univ Calif Irvine, Dept Mech & Aerosp Engn, Dept Anat & Neurobiol, Dept Biomed Engn, Irvine, CA 92697 USA.
[Boninger, Michael L.] VA Pittsburgh Healthcare Syst, Human Engn Res Labs, Pittsburgh, PA 15206 USA.
RP Cowan, RE (reprint author), Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, 1095 NW 14th Terrace, Miami, FL 33136 USA.
EM rcowan@med.miami.edu
RI Fregly, Benjamin/O-6860-2016;
OI Fregly, Benjamin/0000-0003-1166-4358; Boninger,
Michael/0000-0001-6966-919X
NR 31
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U1 6
U2 57
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-0003
J9 J NEUROENG REHABIL
JI J. NeuroEng. Rehabil.
PD APR 20
PY 2012
VL 9
AR 20
DI 10.1186/1743-0003-9-20
PG 8
WC Engineering, Biomedical; Neurosciences; Rehabilitation
SC Engineering; Neurosciences & Neurology; Rehabilitation
GA 981ZY
UT WOS:000307012700001
PM 22520500
ER
PT J
AU Yang, YZ
AF Yang, Yingzi
TI Wnt signaling in development and disease
SO CELL AND BIOSCIENCE
LA English
DT Review
ID PLANAR CELL POLARITY; BRACHYDACTYLY TYPE-B; LEFT-RIGHT ASYMMETRY;
NEURAL-TUBE DEFECTS; RECEPTOR-RELATED PROTEIN-5; RECESSIVE
ROBINOW-SYNDROME; SYNOVIAL JOINT FORMATION; BONE-MASS; SCLEROSTIN
ANTIBODY; NODAL EXPRESSION
AB Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are specified by both quantitative and directional information. While quantitative information regulates cell proliferation and differentiation, directional information is conveyed in the form of cell polarities instructed by local and global cues. Major morphogens like Wnts play critical roles in embryonic development and they are also important in maintaining tissue homeostasis. Abnormal regulation of these signaling events leads to a diverse array of devastating diseases including cancer. Wnts transduce their signals through several distinct pathways and they regulate vertebrate embryonic development by providing both quantitative and directional information. Here, taking the developing skeletal system as an example, we review our work on Wnt signaling pathways in various aspects of development. We focus particularly on our most recent findings that showed that in vertebrates, Wnt5a acts as a global cue to establishing planar cell polarity (PCP). Our work suggests that Wnt morphogens regulate development by integrating quantitative and directional information. Our work also provides important insights in disease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by human mutations in the Wnt/PCP signaling pathway.
C1 NHGRI, Genet Dis Res Branch, Bethesda, MD 20892 USA.
RP Yang, YZ (reprint author), NHGRI, Genet Dis Res Branch, 49 Convent DriveMSC 4472, Bethesda, MD 20892 USA.
EM yingzi@mail.nih.gov
FU Division of Intramural Research of the National Institutes of Health
FX This review is based on Dr Yingzi Yang's Young Investigator Award
Lecture at the SCBA biennial meeting in Guangzhou, China, in 2011. Dr
Yang would like to thank all current and previous members of the Yang
lab for the hard work that led to this award. This work was supported by
the Division of Intramural Research of the National Institutes of
Health.
NR 66
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U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD APR 20
PY 2012
VL 2
AR 14
DI 10.1186/2045-3701-2-14
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 982RY
UT WOS:000307064300001
PM 22520685
ER
PT J
AU Fujisawa, T
Rubin, B
Suzuki, A
Patel, PS
Gahl, WA
Joshi, BH
Puri, RK
AF Fujisawa, Toshio
Rubin, Benjamin
Suzuki, Akiko
Patel, Prabhudas S.
Gahl, William A.
Joshi, Bharat H.
Puri, Raj K.
TI Cysteamine Suppresses Invasion, Metastasis and Prolongs Survival by
Inhibiting Matrix Metalloproteinases in a Mouse Model of Human
Pancreatic Cancer
SO PLOS ONE
LA English
DT Article
ID INTERLEUKIN-13 RECEPTOR ALPHA-2; NEPHROPATHIC CYSTINOSIS; CELL-LINES;
IN-VITRO; CHILDREN; CARCINOMA; GROWTH; RATS; ANGIOGENESIS; PROGRESSION
AB Background: Cysteamine, an anti-oxidant aminothiol, is the treatment of choice for nephropathic cystinosis, a rare lysosomal storage disease. Cysteamine is a chemo-sensitization and radioprotection agent and its antitumor effects have been investigated in various tumor cell lines and chemical induced carcinogenesis. Here, we investigated whether cysteamine has anti-tumor and anti-metastatic effects in transplantable human pancreatic cancer, an aggressive metastatic disease.
Methodology/Principal Findings: Cysteamine's anti-invasion effects were studied by matrigel invasion and cell migration assays in 10 pancreatic cancer cell lines. To study mechanism of action, we examined cell viability and matrix metalloproteinases (MMPs) activity in the cysteamine-treated cells. We also examined cysteamine's anti-metastasis effect in two orthotopic murine models of human pancreatic cancer by measuring peritoneal metastasis and survival of animals. Cysteamine inhibited both migration and invasion of all ten pancreatic cancer cell lines at concentrations (<25 mM) that caused no toxicity to cells. It significantly decreased MMPs activity (IC50 38-460 mu M) and zymographic gelatinase activity in a dose dependent manner in vitro and in vivo; while mRNA and protein levels of MMP-9, MMP-12 and MMP-14 were slightly increased using the highest cysteamine concentration. In vivo, cysteamine significantly decreased metastasis in two established pancreatic tumor models, although it did not affect the size of primary tumors. Additionally, cysteamine prolonged survival of mice in a dose-dependent manner without causing any toxicity. Similar to the in vitro results, MMP activity was significantly decreased in animal tumors treated with cysteamine. Cysteamine had no clinical or preclinical adverse effects in the host even at the highest dose.
Conclusions/Significance: Our results suggest that cysteamine, an agent with a proven safety profile, may be useful for inhibition of metastasis and prolonging the survival of a host with pancreatic cancer.
C1 [Fujisawa, Toshio; Suzuki, Akiko; Patel, Prabhudas S.; Joshi, Bharat H.; Puri, Raj K.] Ctr Biol Evaluat & Res Food & Drug Adm, Tumor Vaccines & Biotechnol Branch, Div Cellular & Gene Therapies, Bethesda, MD USA.
[Rubin, Benjamin] Johns Hopkins Sch Med, Suburban Hosp, Dept Ophthalmol, Bethesda, MD USA.
[Gahl, William A.] NHGRI, Sect Human Biochem Genet, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
RP Puri, RK (reprint author), Ctr Biol Evaluat & Res Food & Drug Adm, Tumor Vaccines & Biotechnol Branch, Div Cellular & Gene Therapies, Bethesda, MD USA.
EM raj.puri@fda.hhs.gov
NR 39
TC 12
Z9 13
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 20
PY 2012
VL 7
IS 4
AR e34437
DI 10.1371/journal.pone.0034437
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UD
UT WOS:000305339200014
PM 22532830
ER
PT J
AU Graham, JC
Zarbl, H
AF Graham, Jessica C.
Zarbl, Helmut
TI Use of Cell-SELEX to Generate DNA Aptamers as Molecular Probes of
HPV-Associated Cervical Cancer Cells
SO PLOS ONE
LA English
DT Article
ID IN-VITRO SELECTION; NUCLEIC-ACID APTAMERS; TUMOR-SUPPRESSOR;
NONTUMORIGENIC REVERTANTS; EXPONENTIAL ENRICHMENT; SYSTEMATIC EVOLUTION;
MACULAR DEGENERATION; HUMAN-PAPILLOMAVIRUS; E7 ONCOPROTEIN; LIGANDS
AB Background: Disease-specific biomarkers are an important tool for the timely and effective management of pathological conditions, including determination of susceptibility, diagnosis, and monitoring efficacy of preventive or therapeutic strategies. Aptamers, comprising single-stranded or double-stranded DNA or RNA, can serve as biomarkers of disease or biological states. Aptamers can bind to specific epitopes on macromolecules by virtue of their three dimensional structures and, much like antibodies, aptamers can be used to target specific epitopes on the basis of their molecular shape. The Systematic Evolution of Ligands by EXponential enrichment (SELEX) is the approach used to select high affinity aptamers for specific macromolecular targets from among the >10(13) oligomers comprising typical random oligomer libraries. In the present study, we used live cell-based SELEX to identify DNA aptamers which recognize cell surface differences between HPV-transformed cervical carcinoma cancer cells and isogenic, nontumorigenic, revertant cell lines.
Methodology/Principal Findings: Whole-cell SELEX methodology was adapted for use with adherent cell lines (which we termed Adherent Cell-SELEX (AC-SELEX)). Using this approach, we identified high affinity aptamers (nanomolar range K-d) to epitopes specific to the cell surface of two nontumorigenic, nontumorigenic revertants derived from the human cervical cancer HeLa cell line, and demonstrated the loss of these epitopes in another human papillomavirus transformed cervical cancer cell line (SiHa). We also performed preliminary investigation of the aptamer epitopes and their binding characteristics.
Conclusions/Significance: Using AC-SELEX we have generated several aptamers that have high affinity and specificity to the nontumorigenic, revertant of HPV-transformed cervical cancer cells. These aptamers can be used to identify new biomarkers that are related to carcinogenesis. Panels of aptamers, such as these may be useful in predicting the tumorigenic potential and properties of cancer biopsies and aid in the effective management of pathological conditions (diagnosis, predicted outcome, and treatment options).
C1 [Graham, Jessica C.; Zarbl, Helmut] Univ Med & Dent New Jersey, Sch Med, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA.
[Zarbl, Helmut] Canc Inst New Jersey, Div Publ Hlth Sci, Program Carcinogenesis & Chemoprevent, New Brunswick, NJ USA.
[Zarbl, Helmut] Univ Med & Dent New Jersey, NIEHS Ctr Environm Exposures & Dis, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
RP Zarbl, H (reprint author), Univ Med & Dent New Jersey, Sch Med, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA.
EM zarbl@eohsi.rutgers.edu
FU Public Health Services Grant [NIEHS P30ES005022]; New Jersey Commission
on Cancer Research [09-1962-CCR-EO]
FX Supported by Public Health Services Grant #NIEHS P30ES005022 (HZ), a
fellowship to JCG from the New Jersey Commission on Cancer Research,
Award #: 09-1962-CCR-EO, and institutional support from the Robert Wood
Johnson Medical School, UMDNJ. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 37
TC 25
Z9 31
U1 2
U2 51
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 20
PY 2012
VL 7
IS 4
AR e36103
DI 10.1371/journal.pone.0036103
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UD
UT WOS:000305339200128
PM 22536456
ER
PT J
AU Merrins, MJ
Bertram, R
Sherman, A
Satin, LS
AF Merrins, Matthew J.
Bertram, Richard
Sherman, Arthur
Satin, Leslie S.
TI Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates
Oscillations of Pancreatic Islet Metabolism
SO PLOS ONE
LA English
DT Article
ID LIVER 6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE;
SITE-DIRECTED MUTAGENESIS; PULSATILE INSULIN-SECRETION; FRUCTOSE
2,6-BISPHOSPHATE; GLUCOSE-METABOLISM; CRYSTAL-STRUCTURE; GLYCOLYTIC
OSCILLATIONS; BETA-CELLS; MUSCLE PHOSPHOFRUCTOKINASE; LIVING CELLS
AB Pulses of insulin from pancreatic beta-cells help maintain blood glucose in a narrow range, although the source of these pulses is unclear. It has been proposed that a positive feedback circuit exists within the glycolytic pathway, the autocatalytic activation of phosphofructokinase-1 (PFK1), which endows pancreatic beta-cells with the ability to generate oscillations in metabolism. Flux through PFK1 is controlled by the bifunctional enzyme PFK2/FBPase2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) in two ways: via (1) production/degradation of fructose-2,6-bisphosphate (Fru2,6-BP), a potent allosteric activator of PFK1, as well as (2) direct activation of glucokinase due to a protein-protein interaction. In this study, we used a combination of live-cell imaging and mathematical modeling to examine the effects of inducibly-expressed PFK2/FBPase2 mutants on glucose-induced Ca2+ pulsatility in mouse islets. Irrespective of the ability to bind glucokinase, mutants of PFK2/FBPase2 that increased the kinase: phosphatase ratio reduced the period and amplitude of Ca2+ oscillations. Mutants which reduced the kinase: phosphatase ratio had the opposite effect. These results indicate that the main effect of the bifunctional enzyme on islet pulsatility is due to Fru2,6-BP alteration of the threshold for autocatalytic activation of PFK1 by Fru1,6-BP. Using computational models based on PFK1-generated islet oscillations, we then illustrated how moderate elevation of Fru-2,6-BP can increase the frequency of glycolytic oscillations while reducing their amplitude, with sufficiently high activation resulting in termination of slow oscillations. The concordance we observed between PFK2/FBPase2-induced modulation of islet oscillations and the models of PFK1-driven oscillations furthermore suggests that metabolic oscillations, like those found in yeast and skeletal muscle, are shaped early in glycolysis.
C1 [Merrins, Matthew J.; Satin, Leslie S.] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA.
[Merrins, Matthew J.; Satin, Leslie S.] Univ Michigan, Brehm Diabet Ctr, Ann Arbor, MI 48109 USA.
[Bertram, Richard] Florida State Univ, Dept Math, Tallahassee, FL 32306 USA.
[Bertram, Richard] Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA.
[Bertram, Richard] Florida State Univ, Program Mol Biophys, Tallahassee, FL 32306 USA.
[Sherman, Arthur] NIDDKD, Lab Biol Modeling, NIH, Bethesda, MD 20892 USA.
RP Merrins, MJ (reprint author), Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA.
EM mmerrins@umich.edu
OI Merrins, Matthew J./0000-0003-1599-9227
FU National Institutes of Health [F32DK085960, R01DK46409]; National
Science Foundation [NSF-DMS0917664]; NIH/NIDDK; Michigan Diabetes
Research and Training Center (MDRTC) Morphology and Image Analysis Core
[DK20572]
FX This work was supported by the National Institutes of Health
(F32DK085960 to MJM, R01DK46409 to LS), the National Science Foundation
(NSF-DMS0917664 to RB), and the NIH/NIDDK Intramural Research Program
(AS). Additional support was provided by the Michigan Diabetes Research
and Training Center (MDRTC) Morphology and Image Analysis Core
(DK20572). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 55
TC 12
Z9 12
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 20
PY 2012
VL 7
IS 4
AR e34036
DI 10.1371/journal.pone.0034036
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UD
UT WOS:000305339200009
PM 22532827
ER
PT J
AU Moore, JM
Rabaia, NA
Smith, LE
Fagerlie, S
Gurley, K
Loukinov, D
Disteche, CM
Collins, SJ
Kemp, CJ
Lobanenkov, VV
Filippova, GN
AF Moore, James M.
Rabaia, Natalia A.
Smith, Leslie E.
Fagerlie, Sara
Gurley, Kay
Loukinov, Dmitry
Disteche, Christine M.
Collins, Steven J.
Kemp, Christopher J.
Lobanenkov, Victor V.
Filippova, Galina N.
TI Loss of Maternal CTCF Is Associated with Peri-Implantation Lethality of
Ctcf Null Embryos
SO PLOS ONE
LA English
DT Article
ID ENHANCER-BLOCKING ACTIVITY; C-MYC GENE; PROTEIN CTCF; ZYGOTIC
TRANSITION; PREIMPLANTATION EMBRYO; GENOME ACTIVATION; X-INACTIVATION;
BINDING-SITES; MOUSE; EXPRESSION
AB CTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, and higher order chromatin organization. Such multifunctional properties of CTCF suggest an essential role in development. Indeed, a previous report on maternal depletion of CTCF suggested that CTCF is essential for pre-implantation development. To distinguish between the effects of maternal and zygotic expression of CTCF, we studied pre-implantation development in mice harboring a complete loss of function Ctcf knockout allele. Although we demonstrated that homozygous deletion of Ctcf is early embryonically lethal, in contrast to previous observations, we showed that the Ctcf nullizygous embryos developed up to the blastocyst stage (E3.5) followed by peri-implantation lethality (E4.5-E5.5). Moreover, one-cell stage Ctcf nullizygous embryos cultured ex vivo developed to the 16-32 cell stage with no obvious abnormalities. Using a single embryo assay that allowed both genotype and mRNA expression analyses of the same embryo, we demonstrated that pre-implantation development of the Ctcf nullizygous embryos was associated with the retention of the maternal wild type Ctcf mRNA. Loss of this stable maternal transcript was temporally associated with loss of CTCF protein expression, apoptosis of the developing embryo, and failure to further develop an inner cell mass and trophoectoderm ex vivo. This indicates that CTCF expression is critical to early embryogenesis and loss of its expression rapidly leads to apoptosis at a very early developmental stage. This is the first study documenting the presence of the stable maternal Ctcf transcript in the blastocyst stage embryos. Furthermore, in the presence of maternal CTCF, zygotic CTCF expression does not seem to be required for pre-implantation development.
C1 [Moore, James M.; Rabaia, Natalia A.; Smith, Leslie E.; Fagerlie, Sara; Gurley, Kay; Collins, Steven J.; Kemp, Christopher J.; Filippova, Galina N.] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98104 USA.
[Loukinov, Dmitry; Lobanenkov, Victor V.] NIAID, Mol Pathol Sect, Immunopathol Lab, NIH, Rockville, MD USA.
[Disteche, Christine M.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
RP Filippova, GN (reprint author), Fred Hutchinson Canc Res Ctr, Human Biol Div, 1124 Columbia St, Seattle, WA 98104 USA.
EM gfilippo@fhcrc.org
OI Lobanenkov, Victor/0000-0001-6665-3635
FU National Institutes of Health [CA68360]; [GM 46883]
FX This work was supported by National Institutes of Health grant CA68360
(G.N.F. and V. V. L.) and in part by grant GM 46883 (C. M. D.). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 56
TC 17
Z9 18
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 20
PY 2012
VL 7
IS 4
AR e34915
DI 10.1371/journal.pone.0034915
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UD
UT WOS:000305339200027
PM 22532833
ER
PT J
AU Patel, S
Park, H
Bonato, P
Chan, L
Rodgers, M
AF Patel, Shyamal
Park, Hyung
Bonato, Paolo
Chan, Leighton
Rodgers, Mary
TI A review of wearable sensors and systems with application in
rehabilitation
SO JOURNAL OF NEUROENGINEERING AND REHABILITATION
LA English
DT Review
DE Wearable sensors and systems; Home monitoring; Telemedicine; Smart home
ID OBSTRUCTIVE PULMONARY-DISEASE; HEALTH-CARE REFORM; PARKINSONS-DISEASE;
PHYSICAL-ACTIVITY; MONITORING-SYSTEM; ACTIVITY PATTERNS; SUBACUTE
STROKE; FALL DETECTION; ACCELEROMETRY; TECHNOLOGY
AB The aim of this review paper is to summarize recent developments in the field of wearable sensors and systems that are relevant to the field of rehabilitation. The growing body of work focused on the application of wearable technology to monitor older adults and subjects with chronic conditions in the home and community settings justifies the emphasis of this review paper on summarizing clinical applications of wearable technology currently undergoing assessment rather than describing the development of new wearable sensors and systems. A short description of key enabling technologies (i.e. sensor technology, communication technology, and data analysis techniques) that have allowed researchers to implement wearable systems is followed by a detailed description of major areas of application of wearable technology. Applications described in this review paper include those that focus on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders. The integration of wearable and ambient sensors is discussed in the context of achieving home monitoring of older adults and subjects with chronic conditions. Future work required to advance the field toward clinical deployment of wearable sensors and systems is discussed.
C1 [Rodgers, Mary] Univ Maryland, Sch Med, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA.
[Patel, Shyamal; Bonato, Paolo] Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Dept Phys Med & Rehabil, Boston, MA USA.
[Patel, Shyamal] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA.
[Park, Hyung; Chan, Leighton] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
[Bonato, Paolo] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
[Rodgers, Mary] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA.
RP Rodgers, M (reprint author), Univ Maryland, Sch Med, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA.
EM MRodgers@som.umaryland.edu
RI Park, Hyung-Soon/B-3334-2010
OI Park, Hyung-Soon/0000-0003-4274-7420
FU Intramural NIH HHS [Z99 CL999999]
NR 108
TC 239
Z9 245
U1 34
U2 171
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-0003
J9 J NEUROENG REHABIL
JI J. NeuroEng. Rehabil.
PD APR 20
PY 2012
VL 9
AR 21
DI 10.1186/1743-0003-9-21
PG 17
WC Engineering, Biomedical; Neurosciences; Rehabilitation
SC Engineering; Neurosciences & Neurology; Rehabilitation
GA 951YO
UT WOS:000304756900001
PM 22520559
ER
PT J
AU Philpott, CC
AF Philpott, Caroline C.
TI Coming into View: Eukaryotic Iron Chaperones and Intracellular Iron
Delivery
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Review
ID HYPOXIA-INDUCIBLE FACTOR; SACCHAROMYCES-CEREVISIAE; SULFUR CLUSTER;
MONOTHIOL GLUTAREDOXIN; PROTEIN; HIF; FRATAXIN; HYDROXYLASE;
LOCALIZATION; FAMILY
AB Eukaryotic cells contain hundreds of metalloproteins, and ensuring that each protein receives the correct metal ion is a critical task for cells. Recent work in budding yeast and mammalian cells has uncovered a system of iron delivery operating in the cytosolic compartment that involves monothiol glutaredoxins, which bind iron in the form of iron-sulfur clusters, and poly(rC)-binding proteins, which bind Fe(II) directly. In yeast cells, cytosolic monothiol glutaredoxins are required for the formation of heme and iron-sulfur clusters and the metallation of some non-heme iron enzymes. Poly(rC)-binding proteins can act as iron chaperones, delivering iron to target non-heme enzymes through direct protein-protein interactions. Although the molecular details have yet to be explored, these proteins, acting independently or together, may represent the basic cellular machinery for intracellular iron delivery.
C1 NIDDK, Liver Dis Branch, NIH, Bethesda, MD 20892 USA.
RP Philpott, CC (reprint author), NIDDK, Liver Dis Branch, NIH, Bethesda, MD 20892 USA.
EM carolinep@intra.niddk.nih.gov
FU National Institutes of Health of NIDDK
FX This work was supported, in whole or in part, by the National Institutes
of Health Intramural Research Program of NIDDK. This is the second
article in the Thematic Minireview Series on Metals in Biology 2012.
NR 47
TC 44
Z9 47
U1 1
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 20
PY 2012
VL 287
IS 17
BP 13518
EP 13523
DI 10.1074/jbc.R111.326876
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941VZ
UT WOS:000303996300003
PM 22389494
ER
PT J
AU Ji, YW
Sun, SY
Xu, AM
Bhargava, P
Yang, L
Lam, KSL
Gao, B
Lee, CH
Kersten, S
Qi, L
AF Ji, Yewei
Sun, Shengyi
Xu, Aimin
Bhargava, Prerna
Yang, Liu
Lam, Karen S. L.
Gao, Bin
Lee, Chih-Hao
Kersten, Sander
Qi, Ling
TI Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization
in Adipose Tissue and Improves Systemic Glucose Tolerance via
Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID INVARIANT NKT CELLS; INSULIN-RESISTANCE; ALTERNATIVE ACTIVATION;
MICROBIAL INFECTION; MICE; INFLAMMATION; RECEPTOR; PATHWAY; DISEASE; FAT
AB Natural killer T (NKT) cells are important therapeutic targets in various disease models and are under clinical trials for cancer patients. However, their function in obesity and type 2 diabetes remains unclear. Our data show that adipose tissues of both mice and humans contain a population of type 1 NKT cells, whose abundance decreases with increased adiposity and insulin resistance. Although loss-of-function of NKT cells had no effect on glucose tolerance in animals with prolonged high fat diet feeding, activation of NKT cells by lipid agonist alpha-galactosylceramide enhances alternative macrophage polarization in adipose tissue and improves glucose homeostasis in animals at different stages of obesity. Furthermore, the effect of NKT cells is largely mediated by the IL-4/STAT6 signaling axis in obese adipose tissue. Thus, our data identify a novel therapeutic target for the treatment of obesity-associated inflammation and type 2 diabetes.
C1 [Ji, Yewei; Kersten, Sander; Qi, Ling] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
[Sun, Shengyi; Yang, Liu; Qi, Ling] Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY 14853 USA.
[Xu, Aimin; Lam, Karen S. L.] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
[Xu, Aimin; Lam, Karen S. L.] Univ Hong Kong, Ctr Heart Brain Hormone & Hlth Aging, Hong Kong, Hong Kong, Peoples R China.
[Bhargava, Prerna; Lee, Chih-Hao] Harvard Univ, Sch Publ Hlth, Dept Genet, Boston, MA 02115 USA.
[Bhargava, Prerna; Lee, Chih-Hao] Harvard Univ, Sch Publ Hlth, Dept Complex Dis & Nutr, Boston, MA 02115 USA.
[Gao, Bin] NIAAA, Lab Liver Dis, Rockville, MD 20852 USA.
[Kersten, Sander] Wageningen Univ, Div Human Nutr, Nutr Metab & Genom Grp, NL-6700 EV Wageningen, Netherlands.
RP Qi, L (reprint author), Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
EM lq35@cornell.edu
RI Kersten, Sander/A-1116-2011; Xu, Aimin/D-3291-2013; Ji,
Yewei/F-5040-2014;
OI Kersten, Sander/0000-0003-4488-7734; Xu, Aimin/0000-0002-0668-033X; Ji,
Yewei/0000-0002-4249-6812; Sun, Shengyi/0000-0002-1734-3902
FU National Institutes of Health from NIDDK [R01DK075046]; NIDDK
[R01DK082582, R01DK082582-S1]; Hong Kong Collaborative Research Fund
Grant [HKU4/CRF/10]; Netherlands Nutrigenomics Centre; Cornell startup
package; American Diabetes Association [7-08-JF-47, 1-12-CD-04]; Howard
Hughes Medical Institute
FX This work was supported, in whole or in part, by National Institutes of
Health Grant R01DK075046 from NIDDK (to C. H. L.) and Grants R01DK082582
and R01DK082582-S1 from NIDDK (to L. Q.). This work was also supported
by Hong Kong Collaborative Research Fund Grant HKU4/CRF/10 (to A. X. and
K. S. L. L.), Netherlands Nutrigenomics Centre (to S. K.), Cornell
startup package, and American Diabetes Association Grants 7-08-JF-47 and
1-12-CD-04.; Supported by the International Student Research Fellowship
from Howard Hughes Medical Institute.
NR 57
TC 77
Z9 78
U1 2
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 20
PY 2012
VL 287
IS 17
BP 13561
EP 13571
DI 10.1074/jbc.M112.350066
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941VZ
UT WOS:000303996300013
PM 22396530
ER
PT J
AU Timofeeva, OA
Chasovskikh, S
Lonskaya, I
Tarasova, NI
Khavrutskii, L
Tarasov, SG
Zhang, XP
Korostyshevskiy, VR
Cheema, A
Zhang, LH
Dakshanamurthy, S
Brown, ML
Dritschilo, A
AF Timofeeva, Olga A.
Chasovskikh, Sergey
Lonskaya, Irina
Tarasova, Nadya I.
Khavrutskii, Lyuba
Tarasov, Sergey G.
Zhang, Xueping
Korostyshevskiy, Valeriy R.
Cheema, Amrita
Zhang, Lihua
Dakshanamurthy, Sivanesan
Brown, Milton L.
Dritschilo, Anatoly
TI Mechanisms of Unphosphorylated STAT3 Transcription actor Binding to DNA
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ATOMIC-FORCE MICROSCOPY; SCAFFOLD/MATRIX-ATTACHED REGIONS; CRUCIFORM
STRUCTURES; PROTEINS; SITES; GENE; DIFFERENTIATION; THERMOPHORESIS;
EXPRESSION; IDENTIFICATION
AB Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon gamma (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target genes. STAT3 is constitutively phosphorylated in various cancers and drives gene expression from GAS-containing promoters to promote tumorigenesis. Recently, roles for unphosphorylated STAT3 (U-STAT3) have been described in response to cytokine stimulation, in cancers, and in maintenance of heterochromatin stability. However, the mechanisms underlying U-STAT3 binding to DNA has not been fully investigated. Here, we explore STAT3-DNA interactions by atomic force microscopy (AFM) imaging. We observed that U-STAT3 molecules bind to the GAS DNA-binding site as dimers and monomers. In addition, we observed that U-STAT3 binds to AT-rich DNA sequence sites and recognizes specific DNA structures, such as 4-way junctions and DNA nodes, within negatively supercoiled plasmid DNA. These structures are important for chromatin organization and our data suggest a role for U-STAT3 as a chromatin/genome organizer. Unexpectedly, we found that a C-terminal truncated 67.5-kDa STAT3 isoform recognizes single-stranded spacers within cruciform structures that also have a role in chromatin organization and gene expression. This isoform appears to be abundant in the nuclei of cancer cells and, therefore, may have a role in regulation of gene expression. Taken together, our data highlight novel mechanisms by which U-STAT3 binds to DNA and supports U-STAT3 function as a transcriptional activator and a chromatin/genomic organizer.
C1 [Timofeeva, Olga A.; Zhang, Xueping; Cheema, Amrita; Zhang, Lihua; Dakshanamurthy, Sivanesan; Brown, Milton L.; Dritschilo, Anatoly] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20057 USA.
[Timofeeva, Olga A.; Chasovskikh, Sergey; Zhang, Xueping; Dritschilo, Anatoly] Georgetown Univ, Med Ctr, Dept Radiat Med, Washington, DC 20057 USA.
[Lonskaya, Irina; Brown, Milton L.] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20057 USA.
[Korostyshevskiy, Valeriy R.] Georgetown Univ, Med Ctr, Dept Biostat Bioinformat & Biomath, Washington, DC 20057 USA.
[Brown, Milton L.] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Drug Discovery Program, Washington, DC 20057 USA.
[Tarasova, Nadya I.; Khavrutskii, Lyuba] NCI Frederick, Canc & Inflammat Program, Frederick, MD 21702 USA.
[Tarasova, Nadya I.] NCI Frederick, Struct Biophys Lab, Biophys Resource Core, Frederick, MD 21702 USA.
RP Timofeeva, OA (reprint author), Georgetown Univ, Med Ctr, Dept Oncol, Res Bldg,R E216,3970 Reservoir Rd NW, Washington, DC 20057 USA.
EM oat@georgetown.edu
FU National Institutes of Health [CA56036-08]; American Cancer Society [IRG
97-152-17]; National Institutes of Health of the NCI Center for Cancer
Research
FX This work was supported, in whole or in part, by the National Institutes
of Health Grant CA56036-08, American Cancer Society Grant IRG 97-152-17
(to O. T.) and by the National Institutes of Health Intramural Research
Program of the NCI Center for Cancer Research.
NR 53
TC 35
Z9 36
U1 2
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 20
PY 2012
VL 287
IS 17
BP 14192
EP 14200
DI 10.1074/jbc.M111.323899
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 941VZ
UT WOS:000303996300071
PM 22378781
ER
PT J
AU Reinkensmeyer, DJ
Bonato, P
Boninger, ML
Chan, L
Cowan, RE
Fregly, BJ
Rodgers, MM
AF Reinkensmeyer, David J.
Bonato, Paolo
Boninger, Michael L.
Chan, Leighton
Cowan, Rachel E.
Fregly, Benjamin J.
Rodgers, Mary M.
TI Major trends in mobility technology research and development: Overview
of the results of the NSF-WTEC European study
SO JOURNAL OF NEUROENGINEERING AND REHABILITATION
LA English
DT Editorial Material
AB Mobility technologies, including wheelchairs, prostheses, joint replacements, assistive devices, and therapeutic exercise equipment help millions of people participate in desired life activities. Yet, these technologies are not yet fully transformative because many desired activities cannot be pursued or are difficult to pursue for the millions of individuals with mobility related impairments. This WTEC study, initiated and funded by the National Science Foundation, was designed to gather information on European innovations and trends in technology that might lead to greater mobility for a wider range of people. What might these transformative technologies be and how might they arise? Based on visits to leading mobility technology research labs in western Europe, the WTEC panel identified eight major trends in mobility technology research. This commentary summarizes these trends, which are then described in detail in companion papers appearing in this special issue.
C1 [Reinkensmeyer, David J.] Univ Calif Irvine, Dept Biomed Engn, Dept Anat & Neurobiol, Dept Mech & Aerosp Engn, Irvine, CA 92697 USA.
[Bonato, Paolo] Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Dept PM&R, Boston, MA 02114 USA.
[Boninger, Michael L.] Univ Pittsburgh, Sch Med, Dept Phys Med & Rehabil, Pittsburgh, PA 15260 USA.
[Boninger, Michael L.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA 15206 USA.
[Chan, Leighton] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
[Cowan, Rachel E.] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Fregly, Benjamin J.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Rodgers, Mary M.] Univ Maryland, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA.
[Rodgers, Mary M.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA.
RP Reinkensmeyer, DJ (reprint author), Univ Calif Irvine, Dept Biomed Engn, Dept Anat & Neurobiol, Dept Mech & Aerosp Engn, 4200 Engn Gateway, Irvine, CA 92697 USA.
EM dreinken@uci.edu
RI Fregly, Benjamin/O-6860-2016;
OI Fregly, Benjamin/0000-0003-1166-4358; Boninger,
Michael/0000-0001-6966-919X
NR 0
TC 10
Z9 10
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-0003
J9 J NEUROENG REHABIL
JI J. NeuroEng. Rehabil.
PD APR 20
PY 2012
VL 9
AR 22
DI 10.1186/1743-0003-9-22
PG 4
WC Engineering, Biomedical; Neurosciences; Rehabilitation
SC Engineering; Neurosciences & Neurology; Rehabilitation
GA 940AO
UT WOS:000303862600001
PM 22520596
ER
PT J
AU Jiwani, S
Ohr, RJ
Fischer, ER
Hackstadt, T
Alvarado, S
Romero, A
Jewett, TJ
AF Jiwani, Shahanawaz
Ohr, Ryan J.
Fischer, Elizabeth R.
Hackstadt, Ted
Alvarado, Stephenie
Romero, Adriana
Jewett, Travis J.
TI Chlamydia trachomatis Tarp cooperates with the Arp2/3 complex to
increase the rate of actin polymerization
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Chlamydia trachomatis; Tarp; Arp2/3 complex; Actin
ID TYROSINE KINASES; N-WASP; PROTEIN; RECRUITMENT; CELLS; ENTRY;
PHOSPHORYLATION; MECHANISMS; NUCLEATION; FILAMENTS
AB Actin polymerization is required for Chlamydia trachomatis entry into nonphagocytic host cells. Host and chlamydial actin nucleators are essential for internalization of chlamydiae by eukaryotic cells. The host cell Arp2/3 complex and the chlamydial translocated actin recruiting phosphoprotein (Tarp) are both required for entry. Tarp and the Arp2/3 complex exhibit unique actin polymerization kinetics individually, but the molecular details of how these two actin nucleators cooperate to promote bacterial entry is not understood. In this study we provide biochemical evidence that the two actin nucleators act synergistically by co-opting the unique attributes of each to enhance the dynamics of actin filament formation. This process is independent of Tarp phosphorylation. We further demonstrate that Tarp colocalization with actin filaments is independent of the Tarp phosphorylation domain. The results are consistent with a model in which chlamydial and host cell actin nucleators cooperate to increase the rate of actin filament formation. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jiwani, Shahanawaz; Ohr, Ryan J.; Alvarado, Stephenie; Romero, Adriana; Jewett, Travis J.] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA.
[Fischer, Elizabeth R.; Hackstadt, Ted] NIAID, Host Parasite Interact Sect, Intracellular Parasites Lab, Rocky Mt Labs,NIH, Hamilton, MT 59840 USA.
RP Jewett, TJ (reprint author), Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, 6900 Lake Nona Blvd, Orlando, FL 32827 USA.
EM travis.jewett@ucf.edu
FU NIAID, NIH K [5K22AI81729-2]; University of Central Florida; NIAID, NIH
FX The authors wish to recognize members of Mollie W. Jewett laboratory for
helpful discussions as well as acknowledge the technical assistance of
Talia Chavez and Brenda Nguyen. This work was supported by the NIAID,
NIH K award 5K22AI81729-2 and the University of Central Florida to
T.J.J. and the intramural research program of the NIAID, NIH to T.H.
NR 31
TC 11
Z9 11
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD APR 20
PY 2012
VL 420
IS 4
BP 816
EP 821
DI 10.1016/j.bbrc.2012.03.080
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 936VW
UT WOS:000303619100021
PM 22465117
ER
PT J
AU Alfano, CM
Imayama, I
Neuhouser, ML
Kiecolt-Glaser, JK
Smith, AW
Meeske, K
McTiernan, A
Bernstein, L
Baumgartner, KB
Ulrich, CM
Ballard-Barbash, R
AF Alfano, Catherine M.
Imayama, Ikuyo
Neuhouser, Marian L.
Kiecolt-Glaser, Janice K.
Smith, Ashley Wilder
Meeske, Kathleen
McTiernan, Anne
Bernstein, Leslie
Baumgartner, Kathy B.
Ulrich, Cornelia M.
Ballard-Barbash, Rachel
TI Fatigue, Inflammation, and omega-3 and omega-6 Fatty Acid Intake Among
Breast Cancer Survivors
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; TUMOR-NECROSIS-FACTOR;
FISH-OIL; OMEGA-3-FATTY-ACID SUPPLEMENTATION; DIETARY SUPPLEMENTATION;
SEX-HORMONES; HOT FLASHES; BIOMARKERS; WOMEN
AB Purpose
Evidence suggests that inflammation may drive fatigue in cancer survivors. Research in healthy populations has shown reduced inflammation with higher dietary intake of omega-3 polyunsaturated fatty acids (PUFAs), which could potentially reduce fatigue. This study investigated fatigue, inflammation, and intake of omega-3 and omega-6 PUFAs among breast cancer survivors.
Methods
Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis). Analysis of covariance and logistic regression models tested relationships between inflammation and fatigue, inflammation and omega-3 and omega-6 PUFA intake, and PUFA intake and fatigue, controlling for three incremental levels of confounders. Fatigue was analyzed continuously (Piper scales) and dichotomously (SF-36 vitality <= 50).
Results
Behavioral (P = .003) and sensory (P = .001) fatigue scale scores were higher by increasing CRP tertile; relationships were attenuated after adjustment for medication use and comorbidity. Survivors with high CRP had 1.8 times greater odds of fatigue after full adjustment (P < .05). Higher intake of omega-6 relative to omega-3 PUFAs was associated with greater CRP (P = .01 after full adjustment) and greater odds of fatigue (odds ratio, 2.6 for the highest v lowest intake; P < .05).
Conclusion
Results link higher intake of omega-3 PUFAs, decreased inflammation, and decreased physical aspects of fatigue. Future studies should test whether omega-3 supplementation may reduce fatigue among significantly fatigued breast cancer survivors.
C1 [Alfano, Catherine M.] NCI, Off Canc Survivorship, NIH, Bethesda, MD 20892 USA.
[Imayama, Ikuyo; Neuhouser, Marian L.; McTiernan, Anne; Ulrich, Cornelia M.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[McTiernan, Anne] Univ Washington, Seattle, WA 98195 USA.
[Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
[Meeske, Kathleen] Univ So Calif, Los Angeles, CA USA.
[Bernstein, Leslie] City Hope Natl Med Ctr, Duarte, CA 91010 USA.
[Baumgartner, Kathy B.] Univ Louisville, Louisville, KY 40292 USA.
[Ulrich, Cornelia M.] German Canc Res Ctr, D-6900 Heidelberg, Germany.
RP Alfano, CM (reprint author), NCI, Off Canc Survivorship, NIH, 6116 Execut Blvd,Ste 404, Bethesda, MD 20892 USA.
EM alfanoc@mail.nih.gov
RI Kiecolt-Glaser, Janice/A-3236-2009
OI Kiecolt-Glaser, Janice/0000-0003-4900-9578
FU National Cancer Institute (NCI) [N01-CN-75036-20, NO1-CN-05228,
NO1-PC-67010, CA131029]; National Institutes of Health [M01-RR-00037];
Wyeth; [NCRR M01-RR-0997]
FX Supported by National Cancer Institute (NCI) Contracts No.
N01-CN-75036-20, NO1-CN-05228, and NO1-PC-67010. Portions of this work
were conducted through the Clinical Research Center at the University of
Washington and supported by the National Institutes of Health Grant No.
M01-RR-00037 or through the University of New Mexico supported by Grant
No. NCRR M01-RR-0997. J.K.K.-G. was supported by NCI Grant No.
CA131029.; Research Funding: Janice K. Kiecolt-Glaser, National
Institutes of Health; Anne McTiernan, Wyeth
NR 60
TC 37
Z9 41
U1 1
U2 11
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD APR 20
PY 2012
VL 30
IS 12
BP 1280
EP 1287
DI 10.1200/JCO.2011.36.4109
PG 8
WC Oncology
SC Oncology
GA 938TR
UT WOS:000303756500011
PM 22412148
ER
PT J
AU Casanova, JL
Holland, SM
Notarangelo, LD
AF Casanova, Jean-Laurent
Holland, Steven M.
Notarangelo, Luigi D.
TI Inborn Errors of Human JAKs and STATs
SO IMMUNITY
LA English
DT Review
ID HYPER-IGE SYNDROME; SEVERE COMBINED IMMUNODEFICIENCY;
INTERLEUKIN-2-RECEPTOR GAMMA-CHAIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS;
COMBINED IMMUNE-DEFICIENCY; REGULATORY T-CELLS; DEFECTIVE LYMPHOID
DEVELOPMENT; FOLLICULAR-HELPER-CELLS; IL-2 RECEPTOR; CUTTING EDGE
AB Inborn errors of the genes encoding two of the four human JAKs (JAK3 and TYK2) and three of the six human STATs (STAT1, STA T3, and STAT5B) have been described. We review the disorders arising from mutations in these five genes, highlighting the way in which the molecular and cellular pathogenesis of these conditions has been clarified by the discovery of inborn errors of cytokines, hormones, and their receptors, including those interacting with JAKs and STATs. The phenotypic similarities between mice and humans lacking individual JAK-STAT components suggest that the functions of JAKs and STATs are largely conserved in mammals. However, a wide array of phenotypic differences has emerged between mice and humans carrying biallelic null alleles of JAK3, TYK2, STAT1, or STAT5B. Moreover, the high degree of allelic heterogeneity at the human JAK3, TYK2, STAT1, and STAT3 loci has revealed highly diverse immunological and clinical phenotypes, which had not been anticipated.
C1 [Casanova, Jean-Laurent] Rockefeller Univ, Rockefeller Univ Hosp, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10065 USA.
[Casanova, Jean-Laurent] Univ Paris 05, Necker Branch, Lab Human Genet Infect Dis, Paris 75005, France.
[Casanova, Jean-Laurent] Inserm, Necker Med Sch, Paris 75005, France.
[Holland, Steven M.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
[Notarangelo, Luigi D.] Harvard Univ, Sch Med, Childrens Hosp Boston, Manton Ctr Orphan Dis Res, Boston, MA 02115 USA.
[Notarangelo, Luigi D.] Harvard Univ, Sch Med, Div Immunol, Childrens Hosp Boston, Boston, MA 02115 USA.
RP Casanova, JL (reprint author), Rockefeller Univ, Rockefeller Univ Hosp, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10065 USA.
EM jean-laurent.casanova@rockefeller.edu
RI Notarangelo, Luigi/F-9718-2016
OI Notarangelo, Luigi/0000-0002-8335-0262
FU Rockefeller University; Institut National de la Sante et de la Recherche
Medicale; University Paris Descartes; St. Giles Foundation; Rockefeller
University Center for Clinical and Translational Science [UL1RR024143];
National Institute of Allergy and Infectious Diseases [1R37AI095983-01,
5R01AI089970-02]; Manton Foundation; Division of Intramural Research,
National Institute of Allergy and Infectious Diseases, NIH
FX J.L.C. received support from the Rockefeller University, the Institut
National de la Sante et de la Recherche Medicale, the University Paris
Descartes, the St. Giles Foundation, the Rockefeller University Center
for Clinical and Translational Science grant number UL1RR024143, and the
National Institute of Allergy and Infectious Diseases grant numbers
1R37AI095983-01 and 5R01AI089970-02. L.D.N. was supported in part by the
Manton Foundation. S.M.H. was supported by the Division of Intramural
Research, National Institute of Allergy and Infectious Diseases, NIH.
NR 153
TC 105
Z9 110
U1 3
U2 26
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 515
EP 528
DI 10.1016/j.immuni.2012.03.016
PG 14
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900002
PM 22520845
ER
PT J
AU Chen, E
Staudt, LM
Green, AR
AF Chen, Edwin
Staudt, Louis M.
Green, Anthony R.
TI Janus Kinase Deregulation in Leukemia and Lymphoma
SO IMMUNITY
LA English
DT Review
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL LYMPHOMA; JAK2 V617F MUTATION;
ACUTE MEGAKARYOBLASTIC LEUKEMIA; HEMATOPOIETIC STEM-CELL; CHRONIC
MYELOPROLIFERATIVE DISORDERS; JUVENILE MYELOMONOCYTIC LEUKEMIA; ACUTE
MYELOID-LEUKEMIA; OF-FUNCTION MUTATIONS; POLYCYTHEMIA-VERA
AB Genetic alterations affecting members of the Janus kinase (JAK) family have been discovered in a wide array of cancers and are particularly prominent in hematological malignancies. In this review, we focus on the role of such lesions in both myeloid and lymphoid tumors. Oncogenic JAK molecules can activate a myriad of canonical downstream signaling pathways as well as directly interact with chromatin in noncanonical processes, the interplay of which results in a plethora of diverse biological consequences. Deciphering these complexities is shedding unexpected light on fundamental cellular mechanisms and will also be important for improved diagnosis, identification of new therapeutic targets, and the development of stratified approaches to therapy.
C1 [Staudt, Louis M.] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.
[Chen, Edwin; Green, Anthony R.] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 0XY, England.
[Green, Anthony R.] Addenbrookes Hosp, Dept Haematol, Cambridge CB2 0XY, England.
RP Staudt, LM (reprint author), NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.
EM lstaudt@mail.nih.gov; arg1000@cam.ac.uk
FU Leukemia and Lymphoma Research; Kay Kendall Leukaemia Fund; NIHR
Biomedical Cambridge Research Centre; Leukemia and Lymphoma Society of
America; National Institutes of Health
FX Research in the authors' laboratories is supported by the Leukemia and
Lymphoma Research, the Kay Kendall Leukaemia Fund, the NIHR Biomedical
Cambridge Research Centre and the Leukemia and Lymphoma Society of
America (A.R.G.), and the National Institutes of Health (L.M.S.).
NR 119
TC 49
Z9 52
U1 2
U2 14
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 529
EP 541
DI 10.1016/j.immuni.2012.03.017
PG 13
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900003
PM 22520846
ER
PT J
AU O'Shea, JJ
Plenge, R
AF O'Shea, John J.
Plenge, Robert
TI JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated
Disease
SO IMMUNITY
LA English
DT Review
ID GENOME-WIDE ASSOCIATION; REGULATORY T-CELLS; ACTIVE
RHEUMATOID-ARTHRITIS; CORONARY-HEART-DISEASE; INHIBITOR TOFACITINIB
CP-690,550; INFLAMMATORY-BOWEL-DISEASE; PRIMARY BILIARY-CIRRHOSIS;
TRANSCRIPTION FACTOR; IN-VIVO; SUSCEPTIBILITY LOCI
AB The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton (STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for gene regulation that dramatically advanced our understanding of the action of hormones, interferons, colony-stimulating factors, and interleukins. As we learn more about the complexities of immune responses, new insights into the functions of this pathway continue to be revealed, aided by technology that permits genome-wide views. As we celebrate the 20th anniversary of the discovery of this paradigm in cell signaling, it is particularly edifying to see how this knowledge has rapidly been translated to human immune disease. Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
C1 [O'Shea, John J.] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
[Plenge, Robert] Brigham & Womens Hosp, Div Genet, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA.
[Plenge, Robert] Broad Inst & Harvard, Cambridge, MA 02142 USA.
RP O'Shea, JJ (reprint author), NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
EM osheajo@mail.nih.gov
FU Pfizer
FX J.J.O'S. and National Institutes of Health (NIH) hold patents related to
targeting JAKs as targets for immunomodulatory agents and have a
Collaborative Research Agreement and Development Award with Pfizer.
NR 110
TC 254
Z9 268
U1 7
U2 64
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 542
EP 550
DI 10.1016/j.immuni.2012.03.014
PG 9
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900004
PM 22520847
ER
PT J
AU Jin, TC
Perry, A
Jiang, JS
Smith, P
Curry, JA
Unterholzner, L
Jiang, ZZ
Horvath, G
Rathinam, VA
Johnstone, RW
Hornung, V
Latz, E
Bowie, AG
Fitzgerald, KA
Xiao, TS
AF Jin, Tengchuan
Perry, Andrew
Jiang, Jiansheng
Smith, Patrick
Curry, James A.
Unterholzner, Leonie
Jiang, Zhaozhao
Horvath, Gabor
Rathinam, Vijay A.
Johnstone, Ricky W.
Hornung, Veit
Latz, Eicke
Bowie, Andrew G.
Fitzgerald, Katherine A.
Xiao, T. Sam
TI Structures of the HIN Domain: DNA Complexes Reveal Ligand Binding and
Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
SO IMMUNITY
LA English
DT Article
ID INNATE IMMUNE SENSOR; X-RAY-DIFFRACTION; RIG-I; INTRACELLULAR DNA;
FRANCISELLA-TULARENSIS; PATTERN-RECOGNITION; CYTOPLASMIC DNA; RNA
RECOGNITION; DENDRITIC CELLS; ATOMIC-LEVEL
AB Recognition of DNA by the innate immune system is central to antiviral and antibacterial defenses, as well as an important contributor to autoimmune diseases involving self DNA. AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that induce inflammasome formation and interferon production, respectively. Here we present the crystal structures of their HIN domains in complex with double-stranded (ds) DNA. Non-sequence-specific DNA recognition is accomplished through electrostatic attraction between the positively charged HIN domain residues and the dsDNA sugar-phosphate backbone. An intramolecular complex of the AIM2 Pyrin and HIN domains in an autoinhibited state is liberated by DNA binding, which may facilitate the assembly of inflammasomes along the DNA staircase. These findings provide mechanistic insights into dsDNA as the activation trigger and oligomerization platform for the assembly of large innate signaling complexes such as the inflammasomes.
C1 [Jin, Tengchuan; Perry, Andrew; Jiang, Jiansheng; Smith, Patrick; Curry, James A.; Xiao, T. Sam] NIAID, Struct lmmunobiol Unit, Immunol Lab, NIH, Bethesda, MD 20892 USA.
[Unterholzner, Leonie; Bowie, Andrew G.] Trinity Coll Dublin, Trin Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland.
[Jiang, Zhaozhao; Rathinam, Vijay A.; Latz, Eicke; Fitzgerald, Katherine A.] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA.
[Hornung, Veit] Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, Unit Clin Biochem, D-53127 Bonn, Germany.
[Johnstone, Ricky W.] Peter MacCallum Canc Inst, Canc Therapeut Program, Gene Regulat Lab, Melbourne, Vic 3002, Australia.
[Johnstone, Ricky W.] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3054, Australia.
RP Xiao, TS (reprint author), NIAID, Struct lmmunobiol Unit, Immunol Lab, NIH, Bethesda, MD 20892 USA.
EM xiaot@niaid.nih.gov
RI Xiao, Tsan/A-8590-2010; Xiao, Tsan/I-7616-2013; Jin,
Tengchuan/B-5883-2014; Horvath, Gabor/J-3917-2014; Latz,
Eicke/H-3951-2014; Hornung, Veit/C-3565-2012
OI Unterholzner, Leonie/0000-0001-9824-692X; Xiao,
Tsan/0000-0001-9688-475X; Jin, Tengchuan/0000-0002-1395-188X; Horvath,
Gabor/0000-0003-0309-595X; Latz, Eicke/0000-0003-1488-5666; Bowie,
Andrew/0000-0001-5316-4373; Hornung, Veit/0000-0002-4150-194X
FU Division of Intramural Research, National Institute of Allergy and
Infectious Diseases, NIH; Science Foundation Ireland [07/IN1/B934]; NIH
[AI083713, AI067497]; European Research Council [ERC-2009-StG 243046];
DFG [SFB704, SFB670]; NHMRC; Susan G. Komen Breast Cancer Foundation;
Prostate Cancer Foundation of Australia; Cancer Council Victoria;
Leukemia Foundation of Australia; Victorian Breast Cancer Research
Consortium; Victorian Cancer Agency; NERCE
FX We thank the beam line scientists at the Argonne National Laboratory
GM/CA-CAT (Argonne, IL) and the Brookhaven National Laboratory (Upton,
NY) for their support on data collection. The authors would like to
thank A. Mian from LI, NIAID for technical support. We thank R.
Schwartz, M. Lenardo, and D. Margulies for helpful discussions. We thank
D.E. Anderson at the Mass Spectrometry facility of NIDDK for technical
support. T.S.X. is supported by the Division of Intramural Research,
National Institute of Allergy and Infectious Diseases, NIH. A.G.B. and
L.U. are supported by Science Foundation Ireland (07/IN1/B934). K.A.F.
is supported by NIH grants AI083713 and AI067497. E.L. is supported by
NIH grant AI067497. V.H. is supported by the European Research Council
(ERC-2009-StG 243046) and the DFG (SFB704 and SFB670). R.W.J. is a
Principal Research Fellow of the National Health and Medical Research
Council of Australia (NHMRC) and supported by NHMRC Program and Project
Grants, the Susan G. Komen Breast Cancer Foundation, the Prostate Cancer
Foundation of Australia, Cancer Council Victoria, The Leukemia
Foundation of Australia, Victorian Breast Cancer Research Consortium,
and Victorian Cancer Agency. V.A.R. is supported by a NERCE Postdoctoral
fellowship.
NR 64
TC 149
Z9 154
U1 2
U2 19
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 561
EP 571
DI 10.1016/j.immuni.2012.02.014
PG 11
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900009
PM 22483801
ER
PT J
AU Lin, JX
Li, P
Liu, DL
Jin, HT
He, JP
Rasheed, MAU
Rochman, Y
Wang, L
Cui, KR
Liu, CY
Kelsall, BL
Ahmed, R
Leonard, WJ
AF Lin, Jian-Xin
Li, Peng
Liu, Delong
Jin, Hyun Tak
He, Jianping
Rasheed, Mohammed Ata Ur
Rochman, Yrina
Wang, Lu
Cui, Kairong
Liu, Chengyu
Kelsall, Brian L.
Ahmed, Rafi
Leonard, Warren J.
TI Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine
Responses and Normal Immune Function
SO IMMUNITY
LA English
DT Article
ID T-CELLS; IL-2 RECEPTOR; DNA-BINDING; GENE-EXPRESSION; PROMOTER; DIMERS;
ALPHA; DIFFERENTIATION; PROLIFERATION; SEQUENCE
AB Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a-Stat5b double knockin (DKI) N-domain mutant mice in which STAT5 proteins form dimers but not tetramers, identified cytokine-regulated genes whose expression required STAT5 tetramers, and defined dimer versus tetramer consensus motifs. Whereas Stat5-deficient mice exhibited perinatal lethality, DKI mice were viable; thus, STAT5 dimers were sufficient for survival. Nevertheless, STAT5 DKI mice had fewer CD4(+)CD25(+) T cells, NK cells, and CD8(+) T cells, with impaired cytokine-induced and homeostatic proliferation of CD8(+) T cells. Moreover, DKI CD8(+) T cell proliferation after viral infection was diminished and DKI Treg cells did not efficiently control colitis. Thus, tetramerization of STAT5 is critical for cytokine responses and normal immune function, establishing a critical role for STAT5 tetramerization in vivo.
C1 [Lin, Jian-Xin; Li, Peng; Rochman, Yrina; Wang, Lu; Cui, Kairong; Leonard, Warren J.] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
[Liu, Delong] Ctr Informat Technol, Math & Stat Comp Lab, Bethesda, MD 20892 USA.
[Jin, Hyun Tak; Rasheed, Mohammed Ata Ur; Ahmed, Rafi] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA.
[He, Jianping; Kelsall, Brian L.] NIAID, Mucosal Immun Sect, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
[Liu, Chengyu] NHLBI, NIH, Bethesda, MD 20892 USA.
RP Leonard, WJ (reprint author), NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
EM wjl@helix.nih.gov
RI Rasheed, Mohammed/N-2749-2013
FU Division of Intramural Research, NHLBI, NIH, Bethesda, MD
FX We thank N. Raghavachari (NHLBI) for Affymetrix Chip assay, R. Spolski
(NHLBI), R.H. Schwartz, K.-T. Jeang (NIAID), K. Zhao (NHLBI), and P.J.
Munson (CIT) for critical comments, P.J. Munson (CIT) for his input in
Affymetrix analysis, J. Chen (Hematology Branch), R. Spolski, W. Liao,
and C. Robinson for experimental help, other members in the Leonard lab
for suggestions, and C. Robinson for maintaining the mouse colony. We
thank C. Wu, S. Adhya, and S. Simmons for valuable discussions. This
work was supported in part by the Division of Intramural Research,
NHLBI, NIH, Bethesda, MD.
NR 43
TC 54
Z9 59
U1 0
U2 18
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 586
EP 599
DI 10.1016/j.immuni.2012.02.017
PG 14
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900011
PM 22520852
ER
PT J
AU Liu, DF
Peterson, ME
Long, EO
AF Liu, Dongfang
Peterson, Mary E.
Long, Eric O.
TI The Adaptor Protein Crk Controls Activation and Inhibition of Natural
Killer Cells
SO IMMUNITY
LA English
DT Article
ID MHC CLASS-I; CHRONIC VIRAL-INFECTION; COMPLEX CLASS-I; IMMUNE SYNAPSES;
ACTIN CYTOSKELETON; TYROSINE PHOSPHORYLATION; LIVING CELLS; T-CELLS;
RECEPTORS; REORGANIZATION
AB Natural killer (NK) cell inhibitory receptors recruit tyrosine phosphatases to prevent activation, induce phosphorylation and dissociation of the small adaptor Crk from cytoskeleton scaffold complexes, and maintain NK cells in a state of responsiveness to subsequent activation events. How Crk contributes to inhibition is unknown. We imaged primary NK cells over lipid bilayers carrying IgG1 Fc to stimulate CD16 and human leukocyte antigen (HLA)-E to inhibit through receptor CD94-NKG2A. HLA-E alone induced Crk phosphorylation in NKG2A(+) NK cells. At activating synapses with Fc alone, Crk was required for the movement of Fc microclusters and their ability to trigger activation signals. At inhibitory synapses, HLA-E promoted central accumulation of both Fc and phosphorylated Crk and blocked the Fc-induced buildup of F-actin. We propose a unified model for inhibitory receptor function: Crk phosphorylation prevents essential Crk-dependent activation signals and blocks F-actin network formation, thereby reducing constraints on subsequent engagement of activation receptors.
C1 [Liu, Dongfang; Peterson, Mary E.; Long, Eric O.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
RP Long, EO (reprint author), NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
EM elong@nih.gov
RI Long, Eric/G-5475-2011
OI Long, Eric/0000-0002-7793-3728
FU National Institutes of Health, National Institute of Allergy and
Infectious Diseases
FX We thank J. Brzostowski, S. Rajagopalan, and P. Sun for advice and help,
D. Geraghty and M. Robertson for cell lines, and Y. Ohba for the CrkL
biosensor. This work has been supported by the Intramural Research
Program of the National Institutes of Health, National Institute of
Allergy and Infectious Diseases.
NR 51
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Z9 32
U1 0
U2 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 600
EP 611
DI 10.1016/j.immuni.2012.03.007
PG 12
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900012
PM 22464172
ER
PT J
AU Valdez, PA
Vithayathil, PJ
Janelsins, BM
Shaffer, AL
Williamson, PR
Datta, SK
AF Valdez, Patricia A.
Vithayathil, Paul J.
Janelsins, Brian M.
Shaffer, Arthur L.
Williamson, Peter R.
Datta, Sandip K.
TI Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon
Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells
SO IMMUNITY
LA English
DT Article
ID CHRONIC MUCOCUTANEOUS CANDIDIASIS; CRYPTOCOCCUS-NEOFORMANS INFECTION;
ARYL-HYDROCARBON RECEPTOR; HYPER-IGE SYNDROME; ROR-GAMMA-T; TH17
RESPONSES; HELPER-CELLS; HOST-DEFENSE; BETA-GLUCAN; CYCLIC-AMP
AB T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transcription factor IRF4 and suppressed production of IL-17 but not IL-22. We show that IRF4 was required for IL-17 expression but inhibited IL-22 expression, highlighting the potential for discordant regulation of these two cytokines in Th17 cells. The pathogenic fungus Cryptococcus neoformans produces PGE2, and we found that it uses PGE2- and IRF4-dependent mechanisms to specifically inhibit induction of IL-17 during Th17 cell differentiation. Blockade of host PGE2 during infection led to increased IL-17 production from CD4(+) T cells and increased survival of mice. These findings suggest that host-or pathogen-derived PGE2 can act directly on Th17 cells during differentiation to inhibit IL-17-dependent antimicrobial responses.
C1 [Valdez, Patricia A.; Vithayathil, Paul J.; Janelsins, Brian M.; Datta, Sandip K.] NIAID, Bacterial Pathogenesis Unit, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
[Shaffer, Arthur L.] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Williamson, Peter R.] NIAID, Translat Mycol Unit, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Datta, SK (reprint author), NIAID, Bacterial Pathogenesis Unit, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
EM dattas@niaid.nih.gov
OI Datta, Sandip/0000-0003-0243-7815
FU NIH, NIAID
FX We thank R. Munford (NIAID) for discussion and comments on the
manuscript and members of the J. O'Shea (NIAMS) and W. Leonard (NHLBI)
laboratories for assistance in identifying ChIP binding regions. This
work was supported by the Intramural Research Program of the NIH, NIAID.
NR 56
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U1 0
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD APR 20
PY 2012
VL 36
IS 4
BP 668
EP 679
DI 10.1016/j.immuni.2012.02.013
PG 12
WC Immunology
SC Immunology
GA 931ML
UT WOS:000303223900018
PM 22464170
ER
PT J
AU Gellhorn, AC
Chan, L
Martin, B
Friedly, J
AF Gellhorn, Alfred Campbell
Chan, Leighton
Martin, Brook
Friedly, Janna
TI Management Patterns in Acute Low Back Pain The Role of Physical Therapy
SO SPINE
LA English
DT Article
DE physical therapy; low back pain; epidural steroid injection; lumbar
surgery; Medicare; epidemiology
ID RANDOMIZED CLINICAL-TRIAL; PRIMARY-CARE; CLAIMS DATA; BED REST;
OUTCOMES; RECURRENCE; GUIDELINES; SPECIALTY; REHABILITATION;
CLASSIFICATION
AB Study Design. Retrospective cohort study.
Objective. To evaluate the relationship between early physical therapy (PT) for acute low back pain and subsequent use of lumbosacral injections, lumbar surgery, and frequent physician office visits for low back pain.
Summary of Background Data. Wide practice variations exist in the treatment of acute low back pain. PT has been advocated as an effective treatment in this setting although disagreement exists regarding its purported benefits.
Methods. A national 20% sample of the Centers for Medicare and Medicaid Services physician outpatient billing claims was analyzed. Patients were selected who received treatment for low back pain between 2003 and 2004 (n = 439,195). To exclude chronic low back conditions, patients were excluded if they had a prior visit for back pain, lumbosacral injection, or lumbar surgery within the previous year. Main outcome measures were rates of lumbar surgery, lumbosacral injections, and frequent physician office visits for low back pain during the following year.
Results. Based on logistic regression analysis, the adjusted odds ratio for undergoing surgery in the group of enrollees that received PT in the acute phase (<4 weeks) compared to those receiving PT in the chronic phase (>3 months) was 0.38 (95% confidence interval [CI], 0.360.41), adjusting for age, sex, diagnosis, treating physician specialty, and comorbidity. The adjusted odds ratio for receiving a lumbosacral injection in the group receiving PT in the acute phase was 0.46 (95% CI, 0.44-0.49), and the adjusted odds ratio for frequent physician office usage in the group receiving PT in the acute phase was 0.47 (95% CI, 0.44-0.50).
Conclusion. There was a lower risk of subsequent medical service usage among patients who received PT early after an episode of acute low back pain relative to those who received PT at later times. Medical specialty variations exist regarding early use of PT, with potential underutilization among generalist specialties.
C1 [Gellhorn, Alfred Campbell; Friedly, Janna] Univ Washington, Sch Med, Dept Rehabil Med, Seattle, WA 98195 USA.
[Chan, Leighton] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
[Martin, Brook] Univ Washington, Ctr Cost & Outcomes Res, Seattle, WA 98195 USA.
RP Gellhorn, AC (reprint author), 525 W Chester Pike,Suite 203, Havertown, PA 19083 USA.
EM gellhorn@me.com
FU NIH
FX This research was supported by the NIH Intramural Research Program. The
manuscript submitted does not contain information about medical
device(s)/drug(s).
NR 41
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U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD APR 20
PY 2012
VL 37
IS 9
BP 775
EP 782
DI 10.1097/BRS.0b013e3181d79a09
PG 8
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 929MB
UT WOS:000303067600016
PM 21099735
ER
PT J
AU Chen, ZG
Eggerman, TL
Bocharov, AV
Baranova, IN
Vishnyakova, TG
Kurlander, RJ
Csako, G
Patterson, AP
AF Chen, Zhigang
Eggerman, Thomas L.
Bocharov, Alexander V.
Baranova, Irina N.
Vishnyakova, Tatyana G.
Kurlander, Roger J.
Csako, Gyorgy
Patterson, Amy P.
TI Hypermutation of ApoB mRNA by Rat APOBEC-1 Overexpression Mimics
APOBEC-3 Hypermutation
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Article
DE APOBEC-1; APOBEC-3G; hypermutation; editing; HBV
ID HUMAN-IMMUNODEFICIENCY-VIRUS; DNA CYTIDINE DEAMINASE; EDITING PROTEIN;
MOLECULAR-CLONING; HIV-1; VIF; RESTRICTION; COMPONENTS; INFECTION;
IMMUNITY
AB APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally, only a small proportion of viral genomes (< 10(-2)) are hypermutated by APOBEC-3s, but often many cytidines (up to 40%) are converted into uridine. The mechanism of this unique selective hypermutation remains unknown. We found that rat APOBEC-1 overexpression had a hypermutation pattern similar to that of APOBEC-3s on its substrate apolipoprotein B (apoB) mRNA. Transient plasmid transfection of rat APOBEC-1 resulted in 0.4% and 1.8% hypermutations with apoB mRNA in HepG2 and McA7777 cells, respectively. The low frequency of hypermutated apoB mRNA targets was enriched by differential DNA denaturation PCR at 72-76 degrees C, with hypermutation levels increasing up to 67%. Up to 69.6% of cytidines in HepG2 and up to 75.5% of cytidines in McA7777 cells were converted into uridines in the hypermutated apoB mRNA. When rat APOBEC-1 was overexpressed by adenovirus, the hypermutation frequency of apoB mRNA increased from 0.4% to similar to 20% and was readily detected by regular PCR. However, this higher expression efficiency only increased the frequency of hypermutation, not the number of affected cytidines in hypermutated targets. Rat APOBEC-1 hypermutation was modulated by cofactors and eliminated by an E181Q mutation, indicating the role of cofactors in hypermutation. The finding of an APOBEC-3 hypermutation pattern with rat APOBEC-1 suggests that cofactors could also be involved in APOBEC-3 hypermutation. Using hepatitis B virus hypermutation, we found that KSRP increased APOBEC-3C and APOBEC-3B hypermutation. These data show that, like rat APOBEC-1 hypermutation, cellular factors may play a regulatory role in APOBEC-3 hyperrnutation. Published by Elsevier Ltd.
C1 [Patterson, Amy P.] NIH, Off Sci Policy, Off Director, Bethesda, MD 20892 USA.
[Chen, Zhigang; Eggerman, Thomas L.; Bocharov, Alexander V.; Baranova, Irina N.; Vishnyakova, Tatyana G.; Kurlander, Roger J.; Csako, Gyorgy; Patterson, Amy P.] NIH, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA.
[Eggerman, Thomas L.] NIDDK, Div Diabet Endocrinol & Metab Dis, NIH, Bethesda, MD 20892 USA.
RP Patterson, AP (reprint author), NIH, Off Sci Policy, Off Director, 6705 Rockledge Dr,Suite 750, Bethesda, MD 20892 USA.
EM pattersa@od.nih.gov
FU Intramural NIH HHS [Z99 CL999999, Z99 DK999999]
NR 37
TC 4
Z9 4
U1 0
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2836
J9 J MOL BIOL
JI J. Mol. Biol.
PD APR 20
PY 2012
VL 418
IS 1-2
BP 65
EP 81
DI 10.1016/j.jmb.2012.02.005
PG 17
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 926KX
UT WOS:000302831000007
PM 22326345
ER
PT J
AU Chen, J
Lippincott-Schwartz, J
Liu, J
AF Chen, Jing
Lippincott-Schwartz, Jennifer
Liu, Jian
TI Intracellular Spatial Localization Regulated by the Microtubule Network
SO PLOS ONE
LA English
DT Article
ID DROSOPHILA NEUROBLASTS; CELL-DIVISION; CYTOPLASMIC DYNEIN; CORTICAL
POLARITY; SPINDLE POLES; MESSENGER-RNA; LIVING CELLS; PROTEIN; DORSAL;
EMBRYOS
AB The commonly recognized mechanisms for spatial regulation inside the cell are membrane-bounded compartmentalization and biochemical association with subcellular organelles. We use computational modeling to investigate another spatial regulation mechanism mediated by the microtubule network in the cell. Our results demonstrate that the mitotic spindle can impose strong sequestration and concentration effects on molecules with binding affinity for microtubules, especially dynein-directed cargoes. The model can recapitulate the essence of three experimental observations on distinct microtubule network morphologies: the sequestration of germ plasm components by the mitotic spindles in the Drosophila syncytial embryo, the asymmetric cell division initiated by the time delay in centrosome maturation in the Drosophila neuroblast, and the diffusional block between neighboring energids in the Drosophila syncytial embryo. Our model thus suggests that the cell cycle-dependent changes in the microtubule network are critical for achieving different spatial regulation effects. The microtubule network provides a spatially extensive docking platform for molecules and gives rise to a "structured cytoplasm", in contrast to a free and fluid environment.
C1 [Chen, Jing; Liu, Jian] NHLBI, NIH, Bethesda, MD 20892 USA.
[Lippincott-Schwartz, Jennifer] NICHHD, NIH, Bethesda, MD 20892 USA.
RP Chen, J (reprint author), NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
EM Jian.Liu@nih.gov
RI Chen, Jing/D-4845-2016
OI Chen, Jing/0000-0001-6321-0505
FU National Heart, Lung and Blood Institute at National Institutes of
Health (NIH); National Institute of Child Health and Human Development
at NIH
FX Dr. Chen and Dr. Liu were supported by the Intramural Research Program
of National Heart, Lung and Blood Institute at National Institutes of
Health (NIH); Dr. Lippincott-Schwartz was supported by the Intramural
Research Program of National Institute of Child Health and Human
Development at NIH. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 32
TC 8
Z9 8
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 19
PY 2012
VL 7
IS 4
AR e34919
DI 10.1371/journal.pone.0034919
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959TL
UT WOS:000305336200013
PM 22532834
ER
PT J
AU DeBaun, MR
Sarnaik, SA
Rodeghier, MJ
Minniti, CP
Howard, TH
Iyer, RV
Inusa, B
Telfer, PT
Kirby-Allen, M
Quinn, CT
Bernaudin, F
Airewele, G
Woods, GM
Panepinto, JA
Fuh, B
Kwiatkowski, JK
King, AA
Rhodes, MM
Thompson, AA
Heiny, ME
Redding-Lallinger, RC
Kirkham, FJ
Sabio, H
Gonzalez, CE
Saccente, SL
Kalinyak, KA
Strouse, JJ
Fixler, JM
Gordon, MO
Miller, JP
Noetzel, MJ
Ichord, RN
Casella, JF
AF DeBaun, Michael R.
Sarnaik, Sharada A.
Rodeghier, Mark J.
Minniti, Caterina P.
Howard, Thomas H.
Iyer, Rathi V.
Inusa, Baba
Telfer, Paul T.
Kirby-Allen, Melanie
Quinn, Charles T.
Bernaudin, Francoise
Airewele, Gladstone
Woods, Gerald M.
Panepinto, Julie Ann
Fuh, Beng
Kwiatkowski, Janet K.
King, Allison A.
Rhodes, Melissa M.
Thompson, Alexis A.
Heiny, Mark E.
Redding-Lallinger, Rupa C.
Kirkham, Fenella J.
Sabio, Hernan
Gonzalez, Corina E.
Saccente, Suzanne L.
Kalinyak, Karen A.
Strouse, John J.
Fixler, Jason M.
Gordon, Mae O.
Miller, J. Phillip
Noetzel, Michael J.
Ichord, Rebecca N.
Casella, James F.
TI Associated risk factors for silent cerebral infarcts in sickle cell
anemia: low baseline hemoglobin, sex, and relative high systolic blood
pressure
SO BLOOD
LA English
DT Article
ID CENTRAL-NERVOUS-SYSTEM; TRANSFUSION SIT TRIAL; PULMONARY-HYPERTENSION;
YOUNG-CHILDREN; DISEASE; BRAIN; STROKE; ABNORMALITIES; MRI;
COMPLICATIONS
AB The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbS beta degrees thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761. (Blood. 2012; 19(16):3684-3690)
C1 [DeBaun, Michael R.] Vanderbilt Univ, Dept Pediat, Div Hematol Oncol, Nashville, TN 37232 USA.
[Sarnaik, Sharada A.] Wayne State Univ, Dept Pediat, Div Hematol Oncol, Detroit, MI 48202 USA.
[Rodeghier, Mark J.] Rodeghier Consultants, Chicago, IL USA.
[Minniti, Caterina P.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Howard, Thomas H.] Univ Alabama Birmingham, Div Hematol Oncol, Dept Pediat, Birmingham, AL 35294 USA.
[Iyer, Rathi V.] Univ Mississippi, Med Ctr, Dept Pediat, Div Hematol Oncol, Jackson, MS 39216 USA.
[Inusa, Baba] St Thomas Hosp Natl Hlth Serv Trust, Evelina Childrens Hosp, Dept Paediat, London, England.
[Telfer, Paul T.] Royal London Hosp, Dept Pediat Hematol, London E1 1BB, England.
[Kirby-Allen, Melanie] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Quinn, Charles T.; Kalinyak, Karen A.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH USA.
[Quinn, Charles T.; Kalinyak, Karen A.] Univ Cincinnati, Cincinnati, OH USA.
[Bernaudin, Francoise] Hop Intercommunal Creteil, Dept Pediat, Creteil, France.
[Airewele, Gladstone] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Woods, Gerald M.] Univ Missouri, Dept Pediat, Kansas City, MO 64110 USA.
[Panepinto, Julie Ann] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA.
[Fuh, Beng] Brody Sch Med, Dept Pediat, Greenville, NC USA.
[Kwiatkowski, Janet K.; Ichord, Rebecca N.] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
[King, Allison A.; Noetzel, Michael J.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
[Rhodes, Melissa M.] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA.
[Thompson, Alexis A.] Northwestern Univ, Dept Pediat, Chicago, IL 60611 USA.
[Heiny, Mark E.] Indiana Univ Purdue Univ, Dept Pediat, Indianapolis, IN 46202 USA.
[Redding-Lallinger, Rupa C.] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA.
[Kirkham, Fenella J.] UCL, Inst Child Hlth, Neurosci Unit, London, England.
[Sabio, Hernan] Wake Forest Univ Hlth Sci, Dept Pediat, Winston Salem, NC USA.
[Gonzalez, Corina E.] Georgetown Univ Hosp, Dept Pediat, Washington, DC 20007 USA.
[Saccente, Suzanne L.] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
[Strouse, John J.; Casella, James F.] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA.
[Fixler, Jason M.] Sinai Hosp, Sch Med, Baltimore, MD 21215 USA.
[Gordon, Mae O.] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA.
[Miller, J. Phillip] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.
[Noetzel, Michael J.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
RP DeBaun, MR (reprint author), Vanderbilt Univ, Dept Pediat, Monroe Carell Jr Childrens Hosp Vanderbilt, Sch Med, 2200 Childrens Way, Nashville, TN 37232 USA.
EM m.debaun@vanderbilt.edu
RI Kirkham, Fenella/C-2442-2009; Quinn, Charles/J-6842-2012;
OI Kirkham, Fenella/0000-0002-2443-7958; Quinn,
Charles/0000-0002-2372-2175; King, Allison/0000-0002-1951-6176
FU National Institutes of Health [U01-NS42804]
FX This work was supported by the National Institutes of Health (grant
U01-NS42804; M.R.D.).
NR 33
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U1 0
U2 3
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 19
PY 2012
VL 119
IS 16
BP 3684
EP 3690
DI 10.1182/blood-2011-05-349621
PG 7
WC Hematology
SC Hematology
GA 959AM
UT WOS:000305282100011
PM 22096242
ER
PT J
AU Deffenbacher, KE
Iqbal, J
Sanger, W
Shen, YL
Lachel, C
Liu, ZF
Liu, YY
Lim, MS
Perkins, SL
Fu, K
Smith, L
Lynch, J
Staudt, LM
Rimsza, LM
Jaffe, E
Rosenwald, A
Ott, GK
Delabie, J
Campo, E
Gascoyne, RD
Cairo, MS
Weisenburger, DD
Greiner, TC
Gross, TG
Chan, WC
AF Deffenbacher, Karen E.
Iqbal, Javeed
Sanger, Warren
Shen, Yulei
Lachel, Cynthia
Liu, Zhongfeng
Liu, Yanyan
Lim, Megan S.
Perkins, Sherrie L.
Fu, Kai
Smith, Lynette
Lynch, James
Staudt, Louis M.
Rimsza, Lisa M.
Jaffe, Elaine
Rosenwald, Andreas
Ott, German K.
Delabie, Jan
Campo, Elias
Gascoyne, Randy D.
Cairo, Mitchell S.
Weisenburger, Dennis D.
Greiner, Timothy C.
Gross, Thomas G.
Chan, Wing C.
TI Molecular distinctions between pediatric and adult mature B-cell
non-Hodgkin lymphomas identified through genomic profiling
SO BLOOD
LA English
DT Article
ID CHEMOTHERAPY PLUS RITUXIMAB; BURKITTS-LYMPHOMA; GENE-EXPRESSION;
CHROMOSOMAL ALTERATIONS; COPY NUMBER; ADOLESCENTS; CHILDREN; PROTEIN;
SURVIVAL; TRIAL
AB Burkitt lymphoma (BL) predominates in pediatric patients, whereas diffuse large B-cell lymphoma (DLBCL) is uncommon. In contrast to adults, BL and DLBCL are treated similarly in children and both entities have superior outcomes in children compared with adults. Gene expression profiling (GEP) and miRNA expression profiling clearly differentiated pediatric DLBCL from BL, forming distinct clusters regardless of patient age. However, pathway analysis of GEP data identified minor differences between corresponding pediatric and adult tumors. Predominance (6:1) of the germinal center B-cell subtype to activated B-cell subtype was found among pediatric DLBCL. Two cases were molecularly classified as primary mediastinal B-cell lymphoma. We observed frequent abnormalities in 8q24 in pediatric DLBCL, including MYC rearrangement in 31% (5 of 16) and gain or amplification in 50% (6 of 12) nonrearranged cases. MYC rearrangement was present in 96% (23 of 24) BL cases. Array-based CGH analysis identified abnormalities that are shared between adult and pediatric DLBCL (+12q15, +19q13, -6q), and abnormalities unique to the pediatric cases (-4p14, -19q13.32, +16p11.2), suggesting distinct pathogenetic mechanisms relative to age. Elucidation of the underlying target genes may provide insight into factors that modulate outcome and could provide potential novel therapeutic targets with less toxicity for pediatric patients with B-cell non-Hodgkin lymphoma. (Blood. 2012;119(16):3757-3766)
C1 [Chan, Wing C.] Univ Nebraska Med Ctr, Ctr Res Lymphoma & Leukemia, Dept Pathol & Microbiol, Omaha, NE 68198 USA.
[Sanger, Warren] Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE 68198 USA.
[Lim, Megan S.] Univ Michigan Hlth Syst, Dept Pathol, Ann Arbor, MI USA.
[Perkins, Sherrie L.] Univ Utah, Dept Pathol, Salt Lake City, UT USA.
[Smith, Lynette; Lynch, James] Univ Nebraska Med Ctr, Dept Biostat, Omaha, NE 68198 USA.
[Staudt, Louis M.] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Rimsza, Lisa M.] Univ Arizona, Dept Pathol, Tucson, AZ USA.
[Jaffe, Elaine] NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Rosenwald, Andreas] Univ Wurzburg, Dept Pathol, D-8700 Wurzburg, Germany.
[Ott, German K.] Robert Bosch Krankenhaus, Dept Clin Pathol, Stuttgart, Germany.
[Delabie, Jan] Univ Oslo, Norwegian Radium Hosp, Dept Pathol, Oslo, Norway.
[Campo, Elias] Univ Barcelona, Hosp Clin, Barcelona, Spain.
[Gascoyne, Randy D.] British Columbia Canc Agcy, Ctr Lymphoid Canc, Dept Pathol, Vancouver, BC V5Z 4E6, Canada.
[Gascoyne, Randy D.] British Columbia Canc Agcy, Ctr Lymphoid Canc, Dept Lab Med, Vancouver, BC V5Z 4E6, Canada.
[Cairo, Mitchell S.] Columbia Univ, Dept Pediat, New York, NY 10027 USA.
[Cairo, Mitchell S.] Columbia Univ, Dept Med, New York, NY USA.
[Cairo, Mitchell S.] Columbia Univ, Dept Pathol, New York, NY USA.
[Cairo, Mitchell S.] Columbia Univ, Dept Cell Biol, New York, NY USA.
[Gross, Thomas G.] Nationwide Childrens Hosp, Sect Hematol Oncol Blood & Marrow Transplant, Columbus, OH USA.
RP Chan, WC (reprint author), Univ Nebraska Med Ctr, Ctr Res Lymphoma & Leukemia, Dept Pathol & Microbiol, 983135 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM jchan@unmc.edu
OI Jaffe, Elaine/0000-0003-4632-0301; Delabie, Jan/0000-0001-5023-0689;
Campo, elias/0000-0001-9850-9793
FU National Cancer Institute [5U01/CA114778]; National Institutes of Health
(NIH) [U01/CA84967]; Eppley Core Grant; NIH from the INBRE of the
National Center for Research Resources [P20 RR016469]; Chair's Grant
[U10 CA98543-08]; Statistics and Data Center of the Children's Oncology
Group from the National Cancer Institute, NIH [U10 CA98413-08]
FX This work was supported in part by the National Cancer Institute (grant
5U01/CA114778), National Institutes of Health (NIH; grant U01/CA84967),
and Eppley Core Grant. The University of Nebraska Medical Center
Microarray Core Facility is supported in part by the NIH (grant P20
RR016469) from the INBRE Program of the National Center for Research
Resources. Research is also supported in part by the Chair's Grant
(grant U10 CA98543-08) and Statistics and Data Center (grant U10
CA98413-08) of the Children's Oncology Group from the National Cancer
Institute, NIH.
NR 47
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U1 1
U2 4
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 19
PY 2012
VL 119
IS 16
BP 3757
EP 3766
DI 10.1182/blood-2011-05-349662
PG 10
WC Hematology
SC Hematology
GA 959AM
UT WOS:000305282100019
PM 22374697
ER
PT J
AU Vlachos, A
Rosenberg, PS
Atsidaftos, E
Alter, BP
Lipton, JM
AF Vlachos, Adrianna
Rosenberg, Philip S.
Atsidaftos, Eva
Alter, Blanche P.
Lipton, Jeffrey M.
TI Incidence of neoplasia in Diamond Blackfan anemia: a report from the
Diamond Blackfan Anemia Registry
SO BLOOD
LA English
DT Article
ID MARROW FAILURE SYNDROMES; FANCONI-ANEMIA; NATURAL-HISTORY; CANCER; RISKS
AB Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by red cell aplasia and congenital anomalies. A predisposition to cancer has been suggested but not quantified by case reports. The DBA Registry of North America (DBAR) is the largest established DBA patient cohort, with prospective follow-up since 1991. This report presents the first quantitative assessment of cancer incidence in DBA. Among 608 patients with 9458 person-years of follow-up, 15 solid tumors, 2 acute myeloid leukemias, and 2 cases of myelodysplastic syndrome were diagnosed at a median age of 41 years in patients who had not received a bone marrow transplant. Cancer incidence in DBA was significantly elevated. The observed-to-expected ratio for all cancers combined was 5.4 (P < .05); significant observed-to-expected ratios were 287 for myelodysplastic syndrome, 28 for acute myeloid leukemia, 36 for colon carcinoma, 33 for osteogenic sarcoma, and 12 for female genital cancers. The median survival was 56 years, and the cumulative incidence of solid tumor/leukemia was approximately 20% by age 46 years. As in Fanconi anemia and dyskeratosis congenita, DBA is both an inherited bone marrow failure syndrome and a cancer predisposition syndrome; cancer risks appear lower in DBA than in Fanconi anemia or dyskeratosis congenita. This trial was registered at www.clinicaltrials.gov as #NCT00106015. (Blood. 2012;119(16):3815-3819)
C1 [Vlachos, Adrianna; Atsidaftos, Eva; Lipton, Jeffrey M.] Steven & Alexandra Cohen Childrens Med Ctr New Yo, New Hyde Pk, NY USA.
[Vlachos, Adrianna; Atsidaftos, Eva; Lipton, Jeffrey M.] Feinstein Inst Med Res, Manhasset, NY USA.
[Vlachos, Adrianna; Lipton, Jeffrey M.] Hofstra N Shore Long Isl Jewish Sch Med, Hempstead, NY USA.
[Alter, Blanche P.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Natl Inst Hlth,Dept Hlth & Human Serv, Rockville, MD USA.
RP Vlachos, A (reprint author), Cohen Childrens Med Ctr, 269-01 76th Ave,Rm 255, New Hyde Pk, NY 11040 USA.
EM avlachos@nshs.edu
FU National Heart, Lung, and Blood Institute [R01 HL 079571-07]; Centers
for Disease Control and Prevention; Pediatric Cancer Foundation;
National Institutes of Health and the National Cancer Institute
FX This research was supported in part by grants from the National Heart,
Lung, and Blood Institute (R01 HL 079571-07; A.V., E.A., and J.M.L.),
the Centers for Disease Control and Prevention (A.V.), the Pediatric
Cancer Foundation (J.M.L.), and the Intramural Research Program of the
National Institutes of Health and the National Cancer Institute (P.S.R.
and B.P.A.).
NR 14
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U1 0
U2 7
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 19
PY 2012
VL 119
IS 16
BP 3815
EP 3819
DI 10.1182/blood-2011-08-375972
PG 5
WC Hematology
SC Hematology
GA 959AM
UT WOS:000305282100025
PM 22362038
ER
PT J
AU Bender, MA
Ragoczy, T
Lee, J
Byron, R
Telling, A
Dean, A
Groudine, M
AF Bender, M. A.
Ragoczy, Tobias
Lee, Jongjoo
Byron, Rachel
Telling, Agnes
Dean, Ann
Groudine, Mark
TI The hypersensitive sites of the murine beta-globin locus control region
act independently to affect nuclear localization and transcriptional
elongation
SO BLOOD
LA English
DT Article
ID IN-VIVO; ERYTHROID-DIFFERENTIATION; GENE-TRANSCRIPTION; TARGETED
DELETION; P-TEFB; REVEALS; LCR; HS3; EXPRESSION; DYNAMICS
AB The beta-globin locus control region (LCR) is necessary for high-level beta-globin gene transcription and differentiation-dependent relocation of the beta-globin locus from the nuclear periphery to the central nucleoplasm and to foci of hyperphosphorylated Pol II "transcription factories" (TFys). To determine the contribution of individual LCR DNasel hypersensitive sites (HSs) to transcription and nuclear location, in the present study, we compared beta-globin gene activity and location in erythroid cells derived from mice with deletions of individual HSs, deletions of 2 HSs, and deletion of the whole LCR and found all of the HSs had a similar spectrum of activities, albeit to different degrees. Each HS acts as an independent module to activate expression in an additive manner, and this is correlated with relocation away from the nuclear periphery. In contrast, HSs have redundant activities with respect to association with TFys and the probability that an allele is actively transcribed, as measured by primary RNA transcript FISH. The limiting effect on RNA levels occurs after beta-globin genes associate with TFys, at which time HSs contribute to the amount of RNA arising from each burst of transcription by stimulating transcriptional elongation. (Blood. 2012;119(16):3820-3827)
C1 [Ragoczy, Tobias; Byron, Rachel; Telling, Agnes; Groudine, Mark] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA.
[Bender, M. A.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
[Bender, M. A.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA.
[Lee, Jongjoo; Dean, Ann] NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD USA.
[Groudine, Mark] Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA.
RP Groudine, M (reprint author), Fred Hutchinson Canc Res Ctr, Div Basic Sci, Mailstop A3-025,1100 Fairview Ave N, Seattle, WA 98109 USA.
EM markg@fhcrc.org
FU National Institutes of Health [DK44746, HL065440]; intramural program of
the National Diabetes and Digestive and Kidney Diseases, National
Institutes of Health; Cooley's Anemia Foundation
FX This work was supported by the National Institutes of Health (grants
DK44746 and HL065440 to M.G.), the intramural program of the National
Diabetes and Digestive and Kidney Diseases, National Institutes of
Health (to A.D.), and the Cooley's Anemia Foundation (to M.A.B).
NR 45
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U1 0
U2 5
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD APR 19
PY 2012
VL 119
IS 16
BP 3820
EP 3827
DI 10.1182/blood-2011-09-380485
PG 8
WC Hematology
SC Hematology
GA 959AM
UT WOS:000305282100026
PM 22378846
ER
PT J
AU Hwang, S
Maloney, NS
Bruinsma, MW
Goel, G
Duan, EN
Zhang, L
Shrestha, B
Diamond, MS
Dani, A
Sosnovtsev, SV
Green, KY
Lopez-Otin, C
Xavier, RJ
Thackray, LB
Virgin, HW
AF Hwang, Seungmin
Maloney, Nicole S.
Bruinsma, Monique W.
Goel, Gautam
Duan, Erning
Zhang, Lei
Shrestha, Bimmi
Diamond, Michael S.
Dani, Adish
Sosnovtsev, Stanislav V.
Green, Kim Y.
Lopez-Otin, Carlos
Xavier, Ramnik J.
Thackray, Larissa B.
Virgin, Herbert W.
TI Nondegradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in
Antiviral Activity of Interferon Gamma
SO CELL HOST & MICROBE
LA English
DT Article
ID SECRETORY PATHWAY; VIRUS-INFECTION; IMMUNITY; REPLICATION; LC3;
INFLAMMATION; MACROPHAGES; BIOGENESIS; LIPIDATION; ACTIVATION
AB Host resistance to viral infection requires type I (alpha/beta) and II (gamma) interferon (IFN) production. Another important defense mechanism is the degradative activity of macroautophagy (herein autophagy), mediated by the coordinated action of evolutionarily conserved autophagy proteins (Atg). We show that the Atg5-Atg12/Atg16L1 protein complex, whose prior known function is in autophagosome formation, is required for IFN gamma-mediated host defense against murine norovirus (MNV) infection. Importantly, the direct antiviral activity of IFN gamma against MNV in macrophages required Atg5-Atg12, Atg7, and Atg16L1, but not induction of autophagy, the degradative activity of lysosomal proteases, fusion of autophagosomes and lysosomes, or the Atg8-processing protein Atg4B. IFN gamma, via Atg5-Atg12/Atg16L1, inhibited formation of the membranous cytoplasmic MNV replication complex, where Atg16L1 localized. Thus, the Atg5-Atg12/Atg16L1 complex performs a pivotal, nondegradative role in IFN gamma-mediated antiviral defense, establishing that multicellular organisms have evolved to use portions of the autophagy pathway machinery in a cassette-like fashion for host defense.
C1 [Hwang, Seungmin; Maloney, Nicole S.; Bruinsma, Monique W.; Duan, Erning; Zhang, Lei; Dani, Adish; Thackray, Larissa B.; Virgin, Herbert W.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
[Shrestha, Bimmi; Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
[Goel, Gautam; Xavier, Ramnik J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Gastrointestinal Unit, Boston, MA 02114 USA.
[Goel, Gautam; Xavier, Ramnik J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA.
[Sosnovtsev, Stanislav V.; Green, Kim Y.] NIAID, Infect Dis Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Lopez-Otin, Carlos] Univ Oviedo, Inst Univ Oncol, Fac Med, Dept Bioquim & Biol Mol, E-33006 Oviedo, Spain.
RP Thackray, LB (reprint author), Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
EM thackray@wustl.edu; virgin@wustl.edu
RI zhou, zhenqing/H-4580-2014; Duan, Erning /H-4608-2014; Lopez-Otin,
Carlos/C-6657-2013;
OI Lopez-Otin, Carlos/0000-0001-6964-1904; Hwang,
Seungmin/0000-0003-0846-5462
FU Midwest Regional Center of Excellence for Biodefense and Emerging
Infectious Diseases [U54 AI065982]; National Institutes of Health
[AI054483, CA096511, AI084887]; Rheumatic Diseases Core Center [NIH P30
AR48335]; NCI Cancer Center [P30 CA91842]; ICTS/CTSA [UL1RR024992];
Ministry of Science and Innovation-Spain; Fundacion M. Botin
FX This work was supported by the Midwest Regional Center of Excellence for
Biodefense and Emerging Infectious Diseases (U54 AI065982), National
Institutes of Health grants AI054483, CA096511, and AI084887, and the
Rheumatic Diseases Core Center (NIH P30 AR48335). We thank the Genome
Technology Access Center at Washington University School of Medicine for
help with genomic analysis (supported by NCI Cancer Center Support Grant
number P30 CA91842 and ICTS/CTSA grant number UL1RR024992). Washington
University and H.W.V. receive income based on licenses for MNV
technology. C.L.O. was supported by grants from Ministry of Science and
Innovation-Spain, FP7 (Microenvimet), and Fundacion M. Botin. We would
like to thank Masaaki Komatsu (Tokyo Metropolitan Institute of Medical
Science, Japan) for Atg7F/F mouse, Noboru Mizushima (Tokyo
Medical and Dental University, Japan) for Atg5F/F mouse,
Tamotsu Yoshimori (Osaka University, Japan) for Atg4B/C74A and
Rab7A/T22N constructs. We thank Virgin lab members for their comments on
the manuscript and D. Kreamalmeyer and M. White for managing mouse
colonies.
NR 46
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U1 3
U2 17
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1931-3128
J9 CELL HOST MICROBE
JI Cell Host Microbe
PD APR 19
PY 2012
VL 11
IS 4
BP 397
EP 409
DI 10.1016/j.chom.2012.03.002
PG 13
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA 935BH
UT WOS:000303491500010
PM 22520467
ER
PT J
AU Abolfath, RM
Biswas, PK
Rajnarayanam, R
Brabec, T
Kodym, R
Papiez, L
AF Abolfath, Ramin M.
Biswas, P. K.
Rajnarayanam, R.
Brabec, Thomas
Kodym, Reinhard
Papiez, Lech
TI Multiscale QM/MM Molecular Dynamics Study on the First Steps of Guanine
Damage by Free Hydroxyl Radicals in Solution
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID NUCLEOTIDE EXCISION-REPAIR; MONTE-CARLO-SIMULATION; DNA-BASE DAMAGE;
HYDROGEN ABSTRACTION; STRAND SCISSION; FORCE-FIELD; DENSITY; BACKBONE;
GROMACS; SITES
AB Understanding the damage of DNA bases from hydrogen abstraction by free OH radicals is of particular importance to understanding the indirect effect of ionizing radiation. Previous studies address the problem with truncated DNA bases as ab initio :,quantum simulations required to study Such electronic-spin-dependent processes are computationally expensive. Here, for the first time, we employ a multiscale and hybrid quantum mechanical-molecular mechanical simulation to study the interaction of OH radicals with a guanine-deoxyribose-phosphate DNA molecular unit in the presence of water, where all of the water molecules and the deoxyribose-phosphate fragment are treated with the simplistic classical molecular mechanical scheme. Our result illustrates that the presence of water strongly alters the hydrogen-abstraction reaction as the hydrogen bonding of OH radicals with water restricts the relative orientation of the OH radicals with respect to the DNA base (here, guanine). This results in an angular anisotropy in the chemical pathway and a lower efficiency in the hydrogen-abstraction mechanisms than previously anticipated for identical systems in vacuum. The method can easily be extended to single- and double-stranded DNA without any appreciable computational cost as these molecular units can be treated in the classical subsystem, as has been demonstrated here.
C1 [Abolfath, Ramin M.] Univ Texas Dallas, Sch Nat Sci & Math, Richardson, TX 75080 USA.
[Abolfath, Ramin M.; Brabec, Thomas] Univ Ottawa, Dept Phys, Ottawa, ON K1N 6N5, Canada.
[Biswas, P. K.] Tougaloo Coll, Dept Phys, Tougaloo, MS 39174 USA.
[Biswas, P. K.] NHLBI, Lab Computat Biol, NIH, Rockville, MD 20894 USA.
[Rajnarayanam, R.] SUNY Buffalo, Dept Pharmacol, Buffalo, NY 14260 USA.
[Kodym, Reinhard] Univ Texas SW Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA.
[Papiez, Lech] Indiana Univ, Cyclotron Facil, Bloomington, IN 47408 USA.
RP Abolfath, RM (reprint author), Yale Univ, Sch Med, Dept Therapeut Radiol, 333 Cedar St, New Haven, CT 06520 USA.
EM ramin.abolfath@utdallas.edu; pbiswas@tougaloo.edu
FU MS-INBRE/NIH [P20RR016476]; RIMI/NIH [P20MD002725]
FX We gratefully acknowledge helpful discussion and inspiring ideas with
Dr. David Chen and Dr. Michael Story. P.K.B. acknowledges financial
support from MS-INBRE/NIH Grant #P20RR016476 and RIMI/NIH Grant
#P20MD002725.
NR 42
TC 22
Z9 22
U1 5
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD APR 19
PY 2012
VL 116
IS 15
BP 3940
EP 3945
DI 10.1021/jp300258n
PG 6
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 927QI
UT WOS:000302924600018
PM 22397677
ER
PT J
AU Talan, MI
Ahmet, I
Lakatta, EG
AF Talan, Mark I.
Ahmet, Ismayil
Lakatta, Edward G.
TI Did Clinical Trials in Which Erythropoietin Failed to Reduce Acute
Myocardial Infarct Size Miss a Narrow Therapeutic Window?
SO PLOS ONE
LA English
DT Article
ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; CONTROLLED PILOT TRIAL;
CARDIOPROTECTION; REPERFUSION; RATIONALE; REVEAL; DESIGN
AB Background: To test a hypothesis that in negative clinical trials of erythropoietin in patients with acute myocardial infarction (MI) the erythropoietin (rhEPO) could be administered outside narrow therapeutic window. Despite overwhelming evidence of cardioprotective properties of rhEPO in animal studies, the outcomes of recently concluded phase II clinical trials have failed to demonstrate the efficacy of rhEPO in patients with acute MI. However, the time between symptoms onset and rhEPO administration in negative clinical trials was much longer that in successful animal experiments.
Methodology/Principal Findings: MI was induced in rats either by a permanent ligation of a descending coronary artery or by a 2-hr occlusion followed by a reperfusion. rhEPO, 3000 IU/kg, was administered intraperitoneally at the time of reperfusion, 4 hrs after beginning of reperfusion, or 6 hrs after permanent occlusion. MI size was measured histologically 24 hrs after coronary occlusion. The area of myocardium at risk was similar among groups. The MI size in untreated rats averaged similar to 42% of area at risk, or similar to 24% of left ventricle, and was reduced by more than 50% (p<0.001) in rats treated with rhEPO at the time of reperfusion. The MI size was not affected by treatment administered 4 hrs after reperfusion or 6 hrs after permanent coronary occlusion. Therefore, our study in a rat experimental model of MI demonstrates that rhEPO administered within 2 hrs of a coronary occlusion effectively reduces MI size, but when rhEPO was administered following a delay similar to that encountered in clinical trials, it had no effect on MI size.
Conclusions/Significance: The clinical trials that failed to demonstrate rhEPO efficacy in patients with MI may have missed a narrow therapeutic window defined in animal experiments.
C1 [Talan, Mark I.; Ahmet, Ismayil; Lakatta, Edward G.] NIA, Cardiovasc Sci Lab, Intramural Res Program, Natl Inst Hlth, Baltimore, MD 21224 USA.
RP Talan, MI (reprint author), NIA, Cardiovasc Sci Lab, Intramural Res Program, Natl Inst Hlth, Baltimore, MD 21224 USA.
EM talanm@grc.nia.nih.gov
NR 25
TC 10
Z9 10
U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 18
PY 2012
VL 7
IS 4
AR e34819
DI 10.1371/journal.pone.0034819
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959XD
UT WOS:000305350600032
PM 22529941
ER
PT J
AU Wu, WW
Wang, GH
Insel, PA
Hsiao, CT
Zou, SG
Martin, B
Maudsley, S
Shen, RF
AF Wu, Wells W.
Wang, Guanghui
Insel, Paul A.
Hsiao, Cheng-Te
Zou, Sige
Martin, Bronwen
Maudsley, Stuart
Shen, Rong-Fong
TI Discovery- and target-based protein quantification using iTRAQ and
pulsed Q collision induced dissociation (PQD)
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Pulsed Q collision-induced dissociation (PQD); Linear ion trap; Triple
quadrupole (QqQ); Higher energy collisional dissociation (HCD); iTRAQ
(Isobaric Tag for Relative and Absolute Quantification)
ID TANDEM MASS-SPECTROMETRY; QUADRUPOLE ION-TRAP; IDENTIFICATION;
QUANTITATION; ACQUISITION; PROTEOMICS; SCAN
AB Pulsed Q collision-induced dissociation (PQD) was developed in part to facilitate detection of low-mass reporter ions using labeling reagents (e.g. iTRAQ) on LTQ platforms. It has generally been recognized that the scan speed and sensitivity of an LTQ are superior than those of an Orbitrap using the higher-energy collisional dissociation (HCD). However, the use of PQD in quantitative proteomics is limited, primarily due to the meager reproducibility of reporter ion ratios. Optimizations of PQD for iTRAQ quantification using LTQ have been reported, but a universally applicable strategy for quantifying the less abundant proteins has not been fully established. Adjustments of the AGC target, mu scan, or scan speed offer only incremental improvements in reproducibility. From our experience, however, satisfactory coefficients of variation (CVs) of reporter ion ratios were difficult to achieve using the discovery-based approach. As an alternative, we implemented a target-based approach that obviates data dependency to allow repetitive data acquisitions across chromatographic peaks. Such a strategy generates enough data points for more reliable quantification. Using cAMP treatment in S49 cell lysates and this target-based approach, we were able to validate differentially expressed proteins, which were initially identified as potential candidates using the discovery-based PQD. The target-based strategy also yielded results comparable to those obtained from HCD in an Orbitrap. Our findings should aid LTQ users who desire to explore iTRAQ quantitative proteomics but have limited access to the more costly Orbitrap or other instruments. Published by Elsevier B.V.
C1 [Maudsley, Stuart] NIA, Receptor Pharmacol Unit, NIH, Baltimore, MD 21224 USA.
[Wu, Wells W.; Martin, Bronwen] NIA, Metab Unit, NIH, Baltimore, MD 21224 USA.
[Wang, Guanghui] NHLBI, Prote Core Facil, NIH, Bethesda, MD 20892 USA.
[Insel, Paul A.] Univ Calif San Diego, Dept Pharmacol & Med, La Jolla, CA 92093 USA.
[Hsiao, Cheng-Te; Zou, Sige] NIA, Funct Genom Unit, NIH, Baltimore, MD 21224 USA.
[Shen, Rong-Fong] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
RP Maudsley, S (reprint author), NIA, Receptor Pharmacol Unit, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM maudsleyst@grc.nia.nih.gov; Rongfong.Shen@fda.hhs.gov
FU National Institute on Aging; National Heart, Lung, and Blood Institute,
National Institutes of Health (NIH)
FX This research was supported by the Intramural Research Programs of
National Institute on Aging and National Heart, Lung, and Blood
Institute, National Institutes of Health (NIH). The authors would like
to acknowledge the following for technical advice: Dr. Howard Jaffe,
NINDS, NIH; Drs. Jae C. Schwartz, Mike W. Senko, and John E.P. Syka of
ThermoFisher Scientific Inc.
NR 23
TC 11
Z9 11
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3919
J9 J PROTEOMICS
JI J. Proteomics
PD APR 18
PY 2012
VL 75
IS 8
BP 2480
EP 2487
DI 10.1016/j.jprot.2012.02.027
PG 8
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 941PJ
UT WOS:000303974800018
PM 22397766
ER
PT J
AU Beisel, CL
Updegrove, TB
Janson, B
Storz, G
AF Beisel, Chase L.
Updegrove, Taylor B.
Janson, Ben J.
Storz, Gisela
TI Multiple factors dictate target selection by Hfq-binding small RNAs
SO EMBO JOURNAL
LA English
DT Article
DE base-pairing; Escherichia coli; Spot 42; target prediction
ID ESCHERICHIA-COLI; SOLUBLE-RNA; POSTTRANSCRIPTIONAL CONTROL;
TRANSLATIONAL INITIATION; CATABOLITE REPRESSION; REGULATORY RNAS;
GENE-EXPRESSION; SPOT 42; PREDICTION; GCVB
AB Hfq-binding small RNAs (sRNAs) in bacteria modulate the stability and translational efficiency of target mRNAs through limited base-pairing interactions. While these sRNAs are known to regulate numerous mRNAs as part of stress responses, what distinguishes targets and non-targets among the mRNAs predicted to base pair with Hfq-binding sRNAs is poorly understood. Using the Hfq-binding sRNA Spot 42 of Escherichia coli as a model, we found that predictions using only the three unstructured regions of Spot 42 substantially improved the identification of previously known and novel Spot 42 targets. Furthermore, increasing the extent of base-pairing in single or multiple base-pairing regions improved the strength of regulation, but only for the unstructured regions of Spot 42. We also found that non-targets predicted to base pair with Spot 42 lacked an Hfq-binding site, folded into a secondary structure that occluded the Spot 42 targeting site, or had overlapping Hfq-binding and targeting sites. By modifying these features, we could impart Spot 42 regulation on non-target mRNAs. Our results thus provide valuable insights into the requirements for target selection by sRNAs. The EMBO Journal (2012) 31, 1961-1974. doi:10.1038/emboj.2012.52; Published online 2 March 2012 Subject Categories: RNA
C1 [Beisel, Chase L.; Updegrove, Taylor B.; Janson, Ben J.; Storz, Gisela] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, Bethesda, MD 20892 USA.
RP Beisel, CL (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, 18 Lib Dr,MSC 5430, Bethesda, MD 20892 USA.
EM cbeisel@ncsu.edu; storz@helix.nih.gov
RI Beisel, Chase/D-4823-2015;
OI Beisel, Chase/0000-0003-0650-9943; Storz, Gisela/0000-0001-6698-1241
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development
FX We thank B Tjaden, S Gottesman, and members of the Storz laboratory for
helpful discussions and critical reading of the manuscript. We are
grateful to C Sharma for technical assistance, to A Zhang for providing
the hfq mutant allele, purified Hfq and alpha-Hfq serum, and to MK
Thomason and A Zhang for sharing unpublished data. Work carried out in
the laboratory of GS was supported by the Intramural Program of the
Eunice Kennedy Shriver National Institute of Child Health and Human
Development. CLB is a Gordon and Betty Moore Foundation Fellow of the
Life Sciences Research Foundation.
NR 51
TC 49
Z9 49
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0261-4189
J9 EMBO J
JI Embo J.
PD APR 18
PY 2012
VL 31
IS 8
BP 1961
EP 1974
DI 10.1038/emboj.2012.52
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 930AV
UT WOS:000303108600011
PM 22388518
ER
PT J
AU Patten, ML
Murphy, AP
AF Patten, Matthew L.
Murphy, Aidan P.
TI Relative Disparity Processing in the Dorsal Visual Pathway
SO JOURNAL OF NEUROSCIENCE
LA English
DT Editorial Material
ID STEREOSCOPIC DEPTH-PERCEPTION; NEURONS; AREA; CORTEX; REPRESENTATION;
RESPONSES; COARSE; MOTION; SIGNAL; MT
C1 [Patten, Matthew L.; Murphy, Aidan P.] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
[Murphy, Aidan P.] NIMH, Sect Cognit Neurophysiol & Imaging, Neuropsychol Lab, Bethesda, MD 20892 USA.
RP Patten, ML (reprint author), Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
EM m.l.patten@bham.ac.uk
FU Wellcome Trust [091467, WT091467MA]
NR 12
TC 0
Z9 0
U1 0
U2 6
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 18
PY 2012
VL 32
IS 16
BP 5353
EP 5355
DI 10.1523/JNEUROSCI.0588-12.2012
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA 929FV
UT WOS:000303047600001
PM 22514299
ER
PT J
AU Roesch, MR
Bryden, DW
Cerri, DH
Haney, ZR
Schoenbaum, G
AF Roesch, Matthew R.
Bryden, Daniel W.
Cerri, Domenic H.
Haney, Zachary R.
Schoenbaum, Geoffrey
TI Willingness to Wait and Altered Encoding of Time-Discounted Reward in
the Orbitofrontal Cortex with Normal Aging
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID NUCLEUS-ACCUMBENS CORE; ORBITAL PREFRONTAL CORTEX; WORKING-MEMORY
IMPAIRMENT; IMPULSIVE CHOICE; DECISION-MAKING; BASOLATERAL AMYGDALA;
AGED RATS; PROBABILISTIC REINFORCEMENT; VENTRAL STRIATUM; DIFFERENT
FORMS
AB Normal aging has been associated with cognitive changes, including shifts in responding for time-discounted rewards. The orbitofrontal cortex, an area previously associated with aging-related cognitive changes, is critical for normal discounting. Previously we have shown in a choice task that rats prefer immediate over delayed reward and that neural representations of delayed reward in orbitofrontal cortex were attenuated, whereas immediate reward elicited strong responses. Changes in choice performance were correlated with changes in firing rate in orbitofrontal neurons, suggesting that these reward representations were critical to the rats' ability to wait for reward. Here we asked whether age-dependent changes in discounting behavior were related to changes in the representation of delayed reward in the orbitofrontal cortex. Young (3-6 months) and aged (22-26 months) rats were trained on the same discounting paradigm used previously. We found that aged rats showed less sensitivity to increasing delay preceding reward delivery, shifting behavior away from the delayed reward more slowly than younger rats. This sensitivity was specific to delay, since choice performance did not differ between the two groups when delay was held constant and reward size varied. Aged rats exhibited a corresponding increase in the prevalence of neurons that fired more strongly for delayed reward. Again this change was specific to delay; there was no change in encoding of different-sized rewards. These results suggest that natural aging results in altered representations of reward in orbitofrontal cortex. These changes may relate to the increased ability to delay gratification and reduced impulsivity associated with aging.
C1 [Schoenbaum, Geoffrey] NIDA, Intramural Res Program, Baltimore, MD 21224 USA.
[Roesch, Matthew R.; Bryden, Daniel W.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Roesch, Matthew R.; Bryden, Daniel W.] Univ Maryland, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
[Cerri, Domenic H.; Haney, Zachary R.] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA.
RP Schoenbaum, G (reprint author), NIDA, Intramural Res Program, Baltimore, MD 21224 USA.
EM mroesch@umd.edu; schoenbg@schoenbaumlab.org
FU NIA; NIDA
FX This work was supported by grants from NIA to G.S. and NIDA to M.R.R.
This article was prepared in part while G.S. was employed at University
of Maryland School of Medicine, Baltimore. The opinions expressed in
this article are the author's own and do not reflect the view of the
National Institutes of Health, the Department of Health and Human
Services, or the United States government.
NR 54
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Z9 15
U1 0
U2 8
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 18
PY 2012
VL 32
IS 16
BP 5525
EP 5533
DI 10.1523/JNEUROSCI.0586-12.2012
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 929FV
UT WOS:000303047600016
PM 22514314
ER
PT J
AU Basch, E
Aronson, N
Berg, A
Flum, D
Gabriel, S
Goodman, SN
Helfand, M
Ioannidis, JPA
Lauer, M
Meltzer, D
Mittman, B
Newhouse, R
Normand, SL
Schneeweiss, S
Slutsky, J
Tinetti, M
Yancy, C
AF Basch, Ethan
Aronson, Naomi
Berg, Alfred
Flum, David
Gabriel, Sherine
Goodman, Steven N.
Helfand, Mark
Ioannidis, John P. A.
Lauer, Michael
Meltzer, David
Mittman, Brian
Newhouse, Robin
Normand, Sharon-Lise
Schneeweiss, Sebastian
Slutsky, Jean
Tinetti, Mary
Yancy, Clyde
CA Methodology Comm Patient-Centered
TI Methodological Standards and Patient-Centeredness in Comparative
Effectiveness Research The PCORI Perspective
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID IMPLEMENTATION-RESEARCH; RANDOMIZED-TRIALS; PROPENSITY SCORE;
CLINICAL-TRIALS; QUALITY IMPROVEMENT; PUBLICATION BIAS; MEDICATIONS;
EXPERIENCE; BENEFITS; LESSONS
AB Rigorous methodological standards help to ensure that medical research produces information that is valid and generalizable, and are essential in patient-centered outcomes research (PCOR). Patient-centeredness refers to the extent to which the preferences, decision-making needs, and characteristics of patients are addressed, and is the key characteristic differentiating PCOR from comparative effectiveness research. The Patient Protection and Affordable Care Act signed into law in 2010 created the Patient-Centered Outcomes Research Institute (PCORI), which includes an independent, federally appointed Methodology Committee. The Methodology Committee is charged to develop methodological standards for PCOR. The 4 general areas identified by the committee in which standards will be developed are (1) prioritizing research questions, (2) using appropriate study designs and analyses, (3) incorporating patient perspectives throughout the research continuum, and (4) fostering efficient dissemination and implementation of results. A Congressionally mandated PCORI methodology report (to be issued in its first iteration in May 2012) will begin to provide standards in each of these areas, and will inform future PCORI funding announcements and review criteria. The work of the Methodology Committee is intended to enable generation of information that is relevant and trustworthy for patients, and to enable decisions that improve patient-centered outcomes. JAMA. 2012;307(15):1636-1640 www.jama.com
C1 [Basch, Ethan] Mem Sloan Kettering Canc Ctr, Hlth Outcomes Res Grp, New York, NY 10463 USA.
[Aronson, Naomi] Blue Cross Blue Shield Assoc, Chicago, IL USA.
[Berg, Alfred; Flum, David] Univ Washington, Seattle, WA 98195 USA.
[Gabriel, Sherine] Mayo Clin, Rochester, MN USA.
[Goodman, Steven N.; Ioannidis, John P. A.] Stanford Univ, Stanford, CA 94305 USA.
[Helfand, Mark] Portland VA Med Ctr, Portland, OR USA.
[Lauer, Michael] NHLBI, Bethesda, MD 20892 USA.
[Meltzer, David] Univ Chicago, Chicago, IL 60637 USA.
[Mittman, Brian] Dept Vet Affairs, Sepulveda, CA USA.
[Newhouse, Robin] Univ Maryland, Baltimore, MD 21201 USA.
[Normand, Sharon-Lise; Schneeweiss, Sebastian] Harvard Univ, Sch Med, Boston, MA USA.
[Normand, Sharon-Lise] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Slutsky, Jean] Agcy Healthcare Res & Qual, Rockville, MD USA.
[Tinetti, Mary] Yale Univ, New Haven, CT USA.
[Yancy, Clyde] Northwestern Univ, Chicago, IL 60611 USA.
RP Basch, E (reprint author), Mem Sloan Kettering Canc Ctr, Hlth Outcomes Res Grp, 307 63rd St, New York, NY 10463 USA.
EM ebasch@mskcc.org
RI Schneeweiss, Sebastian/C-2125-2013; Meltzer, David/C-2926-2009
OI Meltzer, David/0000-0003-2790-7393
FU PCORI of the Methodology Committee
FX The authors have completed and submitted the ICMJE Form for Disclosure
of Potential Conflicts of Interest. All of the authors reported
receiving funding from PCORI as members of the Methodology Committee,
including compensation for travel and lodging for PCORI-related meetings
as well as time spent providing service to the PCORI.
NR 45
TC 96
Z9 96
U1 3
U2 26
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 18
PY 2012
VL 307
IS 15
BP 1636
EP 1640
DI 10.1001/jama.2012.466
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 927GU
UT WOS:000302896100026
ER
PT J
AU Kannan, S
Dai, H
Navath, RS
Balakrishnan, B
Jyoti, A
Janisse, J
Romero, R
Kannan, RM
AF Kannan, Sujatha
Dai, Hui
Navath, Raghavendra S.
Balakrishnan, Bindu
Jyoti, Amar
Janisse, James
Romero, Roberto
Kannan, Rangaramanujam M.
TI Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral
Palsy in a Rabbit Model
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID BLOOD-BRAIN-BARRIER; N-ACETYLCYSTEINE; MICROGLIAL ACTIVATION;
ALZHEIMERS-DISEASE; PERINATAL ASPHYXIA; GLUTATHIONE LEVELS; MOTOR
DEFICITS; DRUG-DELIVERY; WHITE-MATTER; CELLS
AB Cerebral palsy (CP) is a chronic childhood disorder with no effective cure. Neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the pathogenesis of CP and disorders such as Alzheimer's disease and multiple sclerosis. Targeting neuroinflammation can be a potent therapeutic strategy. However, delivering drugs across the blood-brain barrier to the target cells for treating diffuse brain injury is a major challenge. We show that systemically administered polyamidoamine dendrimers localize in activated microglia and astrocytes in the brain of newborn rabbits with CP, but not healthy controls. We further demonstrate that dendrimer-based N-acetyl-L-cysteine (NAC) therapy for brain injury suppresses neuroinflammation and leads to a marked improvement in motor function in the CP kits. The well-known and safe clinical profile for NAC, when combined with dendrimer-based targeting, provides opportunities for clinical translation in the treatment of neuroinflammatory disorders in humans. The effectiveness of the dendrimer-NAC treatment, administered in the postnatal period for a prenatal insult, suggests a window of opportunity for treatment of CP in humans after birth.
C1 [Kannan, Sujatha; Dai, Hui; Navath, Raghavendra S.; Balakrishnan, Bindu; Jyoti, Amar; Romero, Roberto; Kannan, Rangaramanujam M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Detroit, MI 48201 USA.
[Kannan, Sujatha; Dai, Hui; Balakrishnan, Bindu; Jyoti, Amar] Wayne State Univ, Detroit Med Ctr, Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA.
[Navath, Raghavendra S.; Kannan, Rangaramanujam M.] Wayne State Univ, Dept Chem Engn & Mat Sci, Detroit, MI 48201 USA.
[Janisse, James] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA.
RP Kannan, S (reprint author), Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA.
EM skannan3@jhmi.edu; romeror@mail.nih.gov; krangar1@jhmi.edu
FU Perinatology Research Branch, Division of Intramural Research, Eunice
Kennedy Shriver National Institute of Child Health and Human Development
(NICHD), NIH; NICHD [5K08HD050652]
FX Supported in part by the Perinatology Research Branch, Division of
Intramural Research, Eunice Kennedy Shriver National Institute of Child
Health and Human Development (NICHD), NIH, and by NICHD 5K08HD050652
(S.K.).
NR 52
TC 57
Z9 58
U1 2
U2 28
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD APR 18
PY 2012
VL 4
IS 130
AR 130ra46
DI 10.1126/scitranslmed.3003162
PG 11
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA 929FE
UT WOS:000303045900003
PM 22517883
ER
PT J
AU Boratyn, GM
Schaffer, AA
Agarwala, R
Altschul, SF
Lipman, DJ
Madden, TL
AF Boratyn, Grzegorz M.
Schaeffer, Alejandro A.
Agarwala, Richa
Altschul, Stephen F.
Lipman, David J.
Madden, Thomas L.
TI Domain enhanced lookup time accelerated BLAST
SO BIOLOGY DIRECT
LA English
DT Article
ID DISTANTLY RELATED PROTEINS; DNA-BINDING SITES; PSI-BLAST; STRUCTURE
ALIGNMENTS; REGULATORY PROTEINS; SEQUENCE ALIGNMENT; DATABASE SEARCHES;
SCORE MATRICES; ACID SEQUENCES; INFORMATION
AB Background: BLAST is a commonly-used software package for comparing a query sequence to a database of known sequences; in this study, we focus on protein sequences. Position-specific-iterated BLAST (PSI-BLAST) iteratively searches a protein sequence database, using the matches in round i to construct a position-specific score matrix (PSSM) for searching the database in round i + 1. Biegert and Soding developed Context-sensitive BLAST (CS-BLAST), which combines information from searching the sequence database with information derived from a library of short protein profiles to achieve better homology detection than PSI-BLAST, which builds its PSSMs from scratch.
Results: We describe a new method, called domain enhanced lookup time accelerated BLAST (DELTA-BLAST), which searches a database of pre-constructed PSSMs before searching a protein-sequence database, to yield better homology detection. For its PSSMs, DELTA-BLAST employs a subset of NCBI's Conserved Domain Database (CDD). On a test set derived from ASTRAL, with one round of searching, DELTA-BLAST achieves a ROC5000 of 0.270 vs. 0.116 for CS-BLAST. The performance advantage diminishes in iterated searches, but DELTA-BLAST continues to achieve better ROC scores than CS-BLAST.
Conclusions: DELTA-BLAST is a useful program for the detection of remote protein homologs. It is available under the "Protein BLAST" link at http://blast.ncbi.nlm.nih.gov.
C1 [Boratyn, Grzegorz M.; Schaeffer, Alejandro A.; Agarwala, Richa; Altschul, Stephen F.; Lipman, David J.; Madden, Thomas L.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
RP Boratyn, GM (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 38A,8600 Rockville Pike, Bethesda, MD 20894 USA.
EM boratyng@ncbi.nlm.nih.gov
FU Intramural Research Program of the NIH, National Library of Medicine
FX This research was supported by the Intramural Research Program of the
NIH, National Library of Medicine.
NR 43
TC 155
Z9 156
U1 2
U2 19
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6150
J9 BIOL DIRECT
JI Biol. Direct
PD APR 17
PY 2012
VL 7
AR 12
DI 10.1186/1745-6150-7-12
PG 15
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 003GJ
UT WOS:000308596200001
PM 22510480
ER
PT J
AU Du, GW
Lewis, MM
Shaffer, ML
Chen, HL
Yang, QX
Mailman, RB
Huang, XM
AF Du, Guangwei
Lewis, Mechelle M.
Shaffer, Michele L.
Chen, Honglei
Yang, Qing X.
Mailman, Richard B.
Huang, Xuemei
TI Serum Cholesterol and Nigrostriatal R2*Values in Parkinson's Disease
SO PLOS ONE
LA English
DT Article
ID BRAIN IRON ACCUMULATION; SUBSTANTIA-NIGRA; BASAL GANGLIA;
NEURODEGENERATIVE DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN;
RISK-FACTORS; IN-VITRO; TRANSFERRIN; DISORDERS
AB Background: The occurrence of Parkinson's disease (PD) is known to be associated both with increased nigrostriatal iron content and with low serum cholesterol and PD, but there has been no study to determine a potential relationship between these two factors.
Methods: High-resolution MRI (T1-, T2, and multiple echo T2*-weighted imaging) and fasting lipid levels were obtained from 40 patients with PD and 29 healthy controls. Iron content was estimated from mean R2* values (R2* = 1/T2*) calculated for each nigrostriatal structure including substantia nigra, caudate, putamen, and globus pallidus. This was correlated with serum cholesterol levels after controlling for age, gender, and statin use.
Results: In patients with PD, higher serum cholesterol levels were associated with lower iron content in the substantia nigra (R = -0.43, p = 0.011 for total-cholesterol, R = -0.31, p = 0.080 for low-density lipoprotein) and globus pallidus (R = -0.38, p = 0.028 for total-cholesterol, R = -0.27, p = 0.127 for low-density lipoprotein), but only a trend toward significant association of higher total-cholesterol with lower iron content in the striatum (R = -0.34, p = 0.052 for caudate; R = -0.32, p = 0.061 for putamen). After adjusting for clinical measures, the cholesterol-iron relationships held or became even stronger in the substantia nigra and globus pallidus, but weaker in the caudate and putamen. There was no significant association between serum cholesterol levels and nigrostriatal iron content for controls.
Conclusions: The data show that higher serum total-cholesterol concentration is associated with lower iron content in substantia nigra and globus pallidus in Parkinson's disease patients. Further studies should investigate whether this is mechanistic or epiphenomenological relationship.
C1 [Du, Guangwei; Lewis, Mechelle M.; Mailman, Richard B.; Huang, Xuemei] Penn State Univ, Milton S Hershey Med Ctr, Dept Neurol, Hershey, PA 17033 USA.
[Lewis, Mechelle M.; Mailman, Richard B.; Huang, Xuemei] Penn State Univ, Milton S Hershey Med Ctr, Dept Pharmacol, Hershey, PA 17033 USA.
[Yang, Qing X.; Huang, Xuemei] Penn State Univ, Milton S Hershey Med Ctr, Dept Radiol, Hershey, PA 17033 USA.
[Yang, Qing X.; Huang, Xuemei] Penn State Univ, Milton S Hershey Med Ctr, Dept Neurosurg, Hershey, PA 17033 USA.
[Huang, Xuemei] Penn State Univ, Milton S Hershey Med Ctr, Dept Kinesiol, Hershey, PA 17033 USA.
[Shaffer, Michele L.] Penn State Univ, Milton S Hershey Med Ctr, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
[Chen, Honglei] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
RP Du, GW (reprint author), Penn State Univ, Milton S Hershey Med Ctr, Dept Neurol, Hershey, PA 17033 USA.
EM Xuemei@psu.edu
OI Mailman, Richard/0000-0003-1353-2738; Chen, Honglei/0000-0003-3446-7779
FU National Institute of Neurological Disorders and Stroke [NS060722];
General Clinical Research Center from National Institutes of Health
(NIH) [M01RR10732]; GCRC [C06RR016499]; Pennsylvania Department of
Health Tobacco CURE Funds; National Institute of Health; National
Institute of Environmental Health Sciences
FX This work was supported by National Institute of Neurological Disorders
and Stroke (NS060722 to XH), General Clinical Research Center grant from
National Institutes of Health (NIH) (M01RR10732) and GCRC Construction
Grant (C06RR016499) awarded to the Pennsylvania State University College
of Medicine, the Pennsylvania Department of Health Tobacco CURE Funds,
and the intramural research program of the National Institute of Health
and the National Institute of Environmental Health Sciences. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 57
TC 7
Z9 7
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2012
VL 7
IS 4
AR e35397
DI 10.1371/journal.pone.0035397
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959WC
UT WOS:000305347400049
PM 22530017
ER
PT J
AU Kwan, JY
Jeong, SY
Van Gelderen, P
Deng, HX
Quezado, MM
Danielian, LE
Butman, JA
Chen, LY
Bayat, E
Russell, J
Siddique, T
Duyn, JH
Rouault, TA
Floeter, MK
AF Kwan, Justin Y.
Jeong, Suh Young
Van Gelderen, Peter
Deng, Han-Xiang
Quezado, Martha M.
Danielian, Laura E.
Butman, John A.
Chen, Lingye
Bayat, Elham
Russell, James
Siddique, Teepu
Duyn, Jeff H.
Rouault, Tracey A.
Floeter, Mary Kay
TI Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal
Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology
SO PLOS ONE
LA English
DT Article
ID AMYOTROPHIC-LATERAL-SCLEROSIS; HIGH-FIELD MRI; PRECENTRAL GYRUS;
CORTICOSPINAL TRACT; MAGNETIC-RESONANCE; PARKINSONS-DISEASE; BRAIN IRON;
CELLULAR-DISTRIBUTION; MOTOR CORTEX; WHITE-MATTER
AB Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by cortical and spinal motor neuron dysfunction. Routine magnetic resonance imaging (MRI) studies have previously shown hypointense signal in the motor cortex on T-2-weighted images in some ALS patients, however, the cause of this finding is unknown. To investigate the utility of this MR signal change as a marker of cortical motor neuron degeneration, signal abnormalities on 3T and 7T MR images of the brain were compared, and pathology was obtained in two ALS patients to determine the origin of the motor cortex hypointensity. Nineteen patients with clinically probable or definite ALS by El Escorial criteria and 19 healthy controls underwent 3T MRI. A 7T MRI scan was carried out on five ALS patients who had motor cortex hypointensity on the 3T FLAIR sequence and on three healthy controls. Postmortem 7T MRI of the brain was performed in one ALS patient and histological studies of the brains and spinal cords were obtained post-mortem in two patients. The motor cortex hypointensity on 3T FLAIR images was present in greater frequency in ALS patients. Increased hypointensity correlated with greater severity of upper motor neuron impairment. Analysis of 7T T-2*-weighted gradient echo imaging localized the signal alteration to the deeper layers of the motor cortex in both ALS patients. Pathological studies showed increased iron accumulation in microglial cells in areas corresponding to the location of the signal changes on the 3T and 7T MRI of the motor cortex. These findings indicate that the motor cortex hypointensity on 3T MRI FLAIR images in ALS is due to increased iron accumulation by microglia.
C1 [Kwan, Justin Y.; Danielian, Laura E.; Chen, Lingye; Floeter, Mary Kay] NINDS, NIH, Bethesda, MD 20892 USA.
[Jeong, Suh Young; Rouault, Tracey A.] NICHHD, Program Mol Med, NIH, Bethesda, MD 20892 USA.
[Van Gelderen, Peter; Duyn, Jeff H.] NINDS, Adv MRI Sect, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA.
[Deng, Han-Xiang; Siddique, Teepu] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
[Quezado, Martha M.] NCI, NIH, Bethesda, MD 20892 USA.
[Butman, John A.] NIH, Ctr Clin, Bethesda, MD 20892 USA.
[Bayat, Elham] George Washington Univ, Dept Neurol, Washington, DC USA.
[Russell, James] Univ Maryland, Dept Neurol, Baltimore, MD 21201 USA.
RP Kwan, JY (reprint author), NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM kwanjy@ninds.nih.gov
RI Butman, John/J-2780-2013;
OI Butman, John/0000-0002-1547-9195; Jeong, Suh Young/0000-0002-6376-7001
FU National Institute of Neurological Disorders and Stroke, National
Institutes of Health [1ZIANS002976-12]; National Institute of Aging
[P01-AG07232, R37-AG15473, P50-AG08702]; Hereditary Disease Foundation;
Iseman Fund; Louis and Rachel Rudin Foundation
FX This research was supported by the Intramural Research Program of the
National Institute of Neurological Disorders and Stroke, National
Institutes of Health (1ZIANS002976-12). The funder had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.; The control tissue was provided by the
New York Brain Bank - The Taub Institute, Columbia University (NYBB),
which is supported by the National Institute of Aging (P01-AG07232,
R37-AG15473, and P50-AG08702), the Hereditary Disease Foundation, the
Iseman Fund, and the Louis and Rachel Rudin Foundation. We gratefully
acknowledge the assistance of Dr. Tian-Xia Wu with statistics and Dr.
Esther Mayron-Holtz for providing the ferritin antibody. The protocol is
registered on clinicaltrials.gov as NCT00334516.
NR 64
TC 52
Z9 52
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2012
VL 7
IS 4
AR e35241
DI 10.1371/journal.pone.0035241
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959WC
UT WOS:000305347400037
PM 22529995
ER
PT J
AU Temiz, NA
Donohue, DE
Bacolla, A
Luke, BT
Collins, JR
AF Temiz, Nuri A.
Donohue, Duncan E.
Bacolla, Albino
Luke, Brian T.
Collins, Jack R.
TI The Role of Methylation in the Intrinsic Dynamics of B- and Z-DNA
SO PLOS ONE
LA English
DT Article
ID UNIQUE TETRANUCLEOTIDE SEQUENCES; MOLECULAR-DYNAMICS; NUCLEIC-ACIDS; Z
TRANSITION; FORCE-FIELD; TO-Z; CONFORMATIONS; OLIGONUCLEOTIDES;
SIMULATIONS; FLEXIBILITY
AB Methylation of cytosine at the 5-carbon position (5mC) is observed in both prokaryotes and eukaryotes. In humans, DNA methylation at CpG sites plays an important role in gene regulation and has been implicated in development, gene silencing, and cancer. In addition, the CpG dinucleotide is a known hot spot for pathologic mutations genome-wide. CpG tracts may adopt left-handed Z-DNA conformations, which have also been implicated in gene regulation and genomic instability. Methylation facilitates this B-Z transition but the underlying mechanism remains unclear. Herein, four structural models of the dinucleotide d(GC)(5) repeat sequence in B-, methylated B-, Z-, and methylated Z-DNA forms were constructed and an aggregate 100 nanoseconds of molecular dynamics simulations in explicit solvent under physiological conditions was performed for each model. Both unmethylated and methylated B-DNA were found to be more flexible than Z-DNA. However, methylation significantly destabilized the BII, relative to the BI, state through the Gp5mC steps. In addition, methylation decreased the free energy difference between B- and Z-DNA. Comparisons of alpha/gamma backbone torsional angles showed that torsional states changed marginally upon methylation for B-DNA, and Z-DNA. Methylation-induced conformational changes and lower energy differences may contribute to the transition to Z-DNA by methylated, over unmethylated, B-DNA and may be a contributing factor to biological function.
C1 [Temiz, Nuri A.; Donohue, Duncan E.; Bacolla, Albino; Luke, Brian T.; Collins, Jack R.] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Informat Syst Program, Adv Biomed Comp Ctr,Sil Res Ctr Excellence, Frederick, MD USA.
[Bacolla, Albino] Univ Texas MD Anderson Canc Ctr, Dept Mol Carcinogenesis, Smithville, TX USA.
RP Temiz, NA (reprint author), SAIC Frederick Inc, Frederick Natl Lab Canc Res, Informat Syst Program, Adv Biomed Comp Ctr,Sil Res Ctr Excellence, Frederick, MD USA.
EM temizna@mail.nih.gov
RI Bacolla, Albino/N-3877-2013
OI Bacolla, Albino/0000-0003-0206-8423
FU Center for Biomedical Informatics and Information Technology
(CBIIT)/Cancer Biomedical Informatics Grid (caBIG) ISRCE yellow task
[09-260]; National Cancer Institute/National Institutes of Health
[HHSN261200800001E]
FX This work was supported by the Center for Biomedical Informatics and
Information Technology (CBIIT)/Cancer Biomedical Informatics Grid
(caBIG) ISRCE yellow task #09-260 to the Frederick National Laboratory
for Cancer Research and National Cancer Institute/National Institutes of
Health contract HHSN261200800001E (to AB). The content of this
publication does not necessarily reflect the views or policies of the
Department of Health and Human Services, nor does mention of trade
names, commercial products, or organizations imply endorsement by the U.
S. Government. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 58
TC 18
Z9 19
U1 5
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2012
VL 7
IS 4
AR e35558
DI 10.1371/journal.pone.0035558
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959WC
UT WOS:000305347400062
PM 22530050
ER
PT J
AU Schuleri, KH
Centola, M
Evers, KS
Zviman, A
Evers, R
Lima, JAC
Lardo, AC
AF Schuleri, Karl H.
Centola, Marco
Evers, Kristine S.
Zviman, Adam
Evers, Robert
Lima, Joao A. C.
Lardo, Albert C.
TI Cardiovascular magnetic resonance characterization of peri-infarct zone
remodeling following myocardial infarction
SO JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
LA English
DT Article
DE Cardiovascular magnetic resonance imaging; Myocardial infarction; Late
gadolinium enhancement; Periinfarct zone; Myocardial strain
ID LEFT-VENTRICULAR DYSFUNCTION; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR;
ISCHEMIC CARDIOMYOPATHY; TISSUE HETEROGENEITY; HEART-FAILURE; BORDER
ZONE; STRAIN; RESYNCHRONIZATION; DYSSYNCHRONY; TACHYCARDIA
AB Background: Clinical studies implementing late gadolinium-enhanced (LGE) cardiovascular magnetic resonance (CMR) studies suggest that the peri-infarct zone (PIZ) contains a mixture of viable and non-viable myocytes, and is associated with greater susceptibility to ventricular tachycardia induction and adverse cardiac outcomes. However, CMR data assessing the temporal formation and functional remodeling characteristics of this complex region are limited. We intended to characterize early temporal changes in scar morphology and regional function in the PIZ.
Methods and results: CMR studies were performed at six time points up to 90 days after induction of myocardial infarction (MI) in eight minipigs with reperfused, anterior-septal infarcts. Custom signal density threshold algorithms, based on the remote myocardium, were applied to define the infarct core and PIZ region for each time point. After the initial post-MI edema subsided, the PIZ decreased by 54% from day 10 to day 90 (p = 0.04). The size of infarct scar expanded by 14% and thinned by 56% from day 3 to 12 weeks (p = 0.004 and p < 0.001, respectively). LVEDV increased from 34.7 +/- 2.2 ml to 47.8 +/- 3.0 ml (day3 and week12, respectively; p < 0.001). At 30 days post-MI, regional circumferential strain was increased between the infarct scar and the PIZ (-2.1 +/- 0.6 and -6.8 +/- 0.9, respectively;* p < 0.05).
Conclusions: The PIZ is dynamic and decreases in mass following reperfused MI. Tensile forces in the PIZ undergo changes following MI. Remodeling characteristics of the PIZ may provide mechanistic insights into the development of life-threatening arrhythmias and sudden cardiac death post-MI.
C1 [Schuleri, Karl H.; Centola, Marco; Evers, Kristine S.; Zviman, Adam; Evers, Robert; Lima, Joao A. C.; Lardo, Albert C.] Johns Hopkins Sch Med, Div Cardiol, Baltimore, MD 21205 USA.
[Centola, Marco] Polo Univ, Azienda Osped San Paolo, Milan, Italy.
[Evers, Robert] NIH, Bethesda, MD 20892 USA.
[Lardo, Albert C.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA.
RP Lardo, AC (reprint author), Johns Hopkins Sch Med, Div Cardiol, 1042 Ross Bldg, Baltimore, MD 21205 USA.
EM al@jhmi.edu
FU NIH [U54 HL081028]; The Donald W. Reynolds foundation
FX This work was supported by NIH grant U54 HL081028, and The Donald W.
Reynolds foundation. The authors thank Norman J. Barker, M. S., R. B. P.
for his expertise and helpful suggestions presenting images and data
visually.
NR 31
TC 18
Z9 18
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1097-6647
J9 J CARDIOVASC MAGN R
JI J. Cardiov. Magn. Reson.
PD APR 17
PY 2012
VL 14
AR 24
DI 10.1186/1532-429X-14-24
PG 10
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
Medical Imaging
GA 942JC
UT WOS:000304039200001
PM 22510220
ER
PT J
AU Rosamond, WD
Chambless, LE
Heiss, G
Mosley, TH
Coresh, J
Whitsel, E
Wagenknecht, L
Ni, HY
Folsom, AR
AF Rosamond, Wayne D.
Chambless, Lloyd E.
Heiss, Gerardo
Mosley, Thomas H.
Coresh, Josef
Whitsel, Eric
Wagenknecht, Lynne
Ni, Hanyu
Folsom, Aaron R.
TI Twenty-Two-Year Trends in Incidence of Myocardial Infarction, Coronary
Heart Disease Mortality, and Case Fatality in 4 US Communities,
1987-2008
SO CIRCULATION
LA English
DT Article
DE epidemiology; mortality rates; myocardial infarction; surveillance;
survival
ID ATHEROSCLEROSIS RISK; SURVEILLANCE; OUTCOMES; EPIDEMIOLOGY; ASSOCIATION;
DEFINITION; CHALLENGES; EXPERIENCE; MINNESOTA; SEVERITY
AB Background-Knowledge of trends in the incidence of and survival after myocardial infarction (MI) in a community setting is important to understanding trends in coronary heart disease (CHD) mortality rates.
Methods and Results-We estimated race-and gender-specific trends in the incidence of hospitalized MI, case fatality, and CHD mortality from community-wide surveillance and validation of hospital discharges and of in-and out-of-hospital deaths among 35- to 74-year-old residents of 4 communities in the Atherosclerosis Risk in Communities (ARIC) Study. Biomarker adjustment accounted for change from reliance on cardiac enzymes to widespread use of troponin measurements over time. During 1987-2008, a total of 30 985 fatal or nonfatal hospitalized acute MI events occurred. Rates of CHD death among persons without a history of MI fell an average 4.7%/y among men and 4.3%/y among women. Rates of both in-and out-of-hospital CHD death declined significantly throughout the period. Age-and biomarker-adjusted average annual rate of incident MI decreased 4.3% among white men, 3.8% among white women, 3.4% among black women, and 1.5% among black men. Declines in CHD mortality and MI incidence were greater in the second decade (1997-2008). Failure to account for biomarker shift would have masked declines in incidence, particularly among blacks. Age-adjusted 28-day case fatality after hospitalized MI declined 3.5%/y among white men, 3.6%/y among black men, 3.0%/y among white women, and 2.6%/y among black women.
Conclusions-Although these findings from 4 communities may not be directly generalizable to blacks and whites in the entire United States, we observed significant declines in MI incidence, primarily as a result of downward trends in rates between 1997 and 2008. (Circulation. 2012; 125: 1848-1857.)
C1 [Rosamond, Wayne D.] Univ N Carolina, Dept Epidemiol, Cardiovasc Epidemiol Program, Sch Med, Chapel Hill, NC 27514 USA.
[Chambless, Lloyd E.] Univ N Carolina, Sch Med, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27514 USA.
[Whitsel, Eric] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27514 USA.
[Mosley, Thomas H.] Univ Mississippi, Dept Med, Sch Med, Jackson, MS USA.
[Coresh, Josef] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Wagenknecht, Lynne] Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA.
[Ni, Hanyu] NHLBI, NIH, Bethesda, MD 20892 USA.
[Folsom, Aaron R.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
RP Rosamond, WD (reprint author), Univ N Carolina, Dept Epidemiol, Cardiovasc Epidemiol Program, Sch Med, Bank Amer Bldg,137 Franklin St,Suite 306, Chapel Hill, NC 27514 USA.
EM Wayne_Rosamond@unc.edu
FU National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016,
N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022]
FX The ARIC Study is performed as a collaborative study supported by
National Heart, Lung, and Blood Institute contracts N01-HC-55015,
N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021,
and N01-HC-55022.
NR 29
TC 107
Z9 111
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD APR 17
PY 2012
VL 125
IS 15
BP 1848
EP +
DI 10.1161/CIRCULATIONAHA.111.047480
PG 46
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 928CM
UT WOS:000302957800012
PM 22420957
ER
PT J
AU Rosenson, RS
Brewer, HB
Davidson, WS
Fayad, ZA
Fuster, V
Goldstein, J
Hellerstein, M
Jiang, XC
Phillips, MC
Rader, DJ
Remaley, AT
Rothblat, GH
Tall, AR
Yvan-Charvet, L
AF Rosenson, Robert S.
Brewer, H. Bryan, Jr.
Davidson, W. Sean
Fayad, Zahi A.
Fuster, Valentin
Goldstein, James
Hellerstein, Marc
Jiang, Xian-Cheng
Phillips, Michael C.
Rader, Daniel J.
Remaley, Alan T.
Rothblat, George H.
Tall, Alan R.
Yvan-Charvet, Laurent
TI Cholesterol Efflux and Atheroprotection Advancing the Concept of Reverse
Cholesterol Transport
SO CIRCULATION
LA English
DT Review
DE lipoproteins; apolipoproteins; atherosclerosis; cardiovascular diseases;
imaging
ID HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; PHOSPHOLIPID TRANSFER
PROTEIN; APOLIPOPROTEIN-A-I; RECEPTOR CLASS-B; RANDOMIZED
CONTROLLED-TRIAL; HEPATIC LIPASE DEFICIENCY; MARROW-DERIVED CELLS;
PRE-BETA-HDL; SCAVENGER RECEPTOR
C1 [Rosenson, Robert S.; Fayad, Zahi A.] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY 10029 USA.
[Brewer, H. Bryan, Jr.] Washington Hosp Ctr, Cardiovasc Res Inst, MedStar Res Inst, Washington, DC 20010 USA.
[Davidson, W. Sean] Univ Cincinnati, Ctr Lipid & Arteriosclerosis Sci, Cincinnati, OH USA.
[Goldstein, James] Oakland Univ, William Beaumont Sch Med, William Beaumont Hosp, Royal Oak, MI USA.
[Hellerstein, Marc] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Hellerstein, Marc] KineMed Inc, Berkeley, CA USA.
[Hellerstein, Marc] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Jiang, Xian-Cheng] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA.
[Phillips, Michael C.; Rothblat, George H.] Univ Penn, Dept Pediat, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Rader, Daniel J.] Univ Penn, Philadelphia, PA 19104 USA.
[Remaley, Alan T.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Remaley, Alan T.; Yvan-Charvet, Laurent] Columbia Univ, Div Mol Med, Med Ctr, New York, NY USA.
RP Rosenson, RS (reprint author), Mt Sinai Sch Med, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1030, New York, NY 10029 USA.
EM robert.rosenson@mssm.edu
RI Fuster, Valentin/H-4319-2015;
OI Fuster, Valentin/0000-0002-9043-9986; Yvan-Charvet,
Laurent/0000-0002-7748-4942
FU Intramural NIH HHS [ZIA HL006095-03]
NR 147
TC 297
Z9 308
U1 6
U2 46
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD APR 17
PY 2012
VL 125
IS 15
BP 1905
EP 1919
DI 10.1161/CIRCULATIONAHA.111.066589
PG 15
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 928CM
UT WOS:000302957800018
PM 22508840
ER
PT J
AU Kunisue, T
Chen, Z
Louis, GMB
Sundaram, R
Hediger, ML
Sun, LP
Kannan, K
AF Kunisue, Tatsuya
Chen, Zhen
Louis, Germaine M. Buck
Sundaram, Rajeshwari
Hediger, Mary L.
Sun, Liping
Kannan, Kurunthachalam
TI Urinary Concentrations of Benzophenone-type UV Filters in U.S. Women and
Their Association with Endometriosis
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID TANDEM MASS-SPECTROMETRY; ISOLATED RAT HEPATOCYTES; YEAST 2-HYBRID
ASSAY; SYSTEMIC ABSORPTION; ESTROGENIC ACTIVITY; IN-VITRO;
POLYCHLORINATED-BIPHENYLS; TOPICAL APPLICATION; MCF-7 CELLS; SUNSCREEN
AB Benzophenone (BP)-type UV filters are widely used in a variety of personal care products for the protection of skin and hair from UV irradiation. Despite the estrogenic potencies of BP derivatives, few studies have examined the occurrence of these compounds in human matrices. Furthermore, associations among exposure to these compounds and estrogen-dependent diseases (such as endometriosis) have not been examined previously. In this study, we determined the concentrations of five BP derivatives, 2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone (2,4OH-BP), 2,2'-dihydroxy-4-methoxybenzophenone (2,2'OH-4MeO-BP), 2,2',4,4'-tetrahydroxybenzophenone (2,2',4,4'OH-BP), and 4-hydroxybenzophenone (4OH-BP), in urine collected from 625 women in Utah and California, using liquid chromatography (LC)-tandem mass spectrometry (MS/MS). The association of urinary concentrations of BP derivatives with an increase in the odds of a diagnosis of endometriosis was examined in 600 women who underwent laparoscopy/laparotomy (n = 473: operative cohort) or pelvic magnetic resonance imaging (n = 127: population cohort), during 2007-2009. 2OH-4MeO-BP, 2,4OH-BP, and 4OH-BP respectively were detected in 99.0%, 93.3%, and 83.8% of the urine samples analyzed, whereas the detection rates for 2,2',4,4'OH-BP and 2,2'OH-4MeO-BP were below 6.0%. Significant regional differences (higher concentrations in California) and monthly variations (higher concentrations in July and August) were found for urinary concentrations of 2OH-4MeO-BP and 2,4OH-BP. In addition, urinary concentrations of 2OH-4MeO-BP and 2,4OH-BP tended to be higher in more affluent, older, and leaner women. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the urinary concentrations of BP derivatives and the odds of an endometriosis diagnosis; ORs increased across quartiles of 2OH-4MeO-BP and 2,4OH-BP concentrations, but a significant trend was observed only between 2,4OH-BP and the odds of an endometriosis diagnosis in the operative cohort (OR = 1.19; 95% CI = 1.01, 1.41). When women in the highest quartile of 2,4OH-BP concentrations were compared with women in the first three quartiles, the OR increased considerably (OR = 1.65; 95% CI = 1.07, 2.53). Given that 2,4OH-BP possesses an estrogenic activity higher than that of 2OH-4MeO-BP, our results invite the speculation that exposure to elevated 2,4OH-BP levels may be associated with endometriosis.
C1 [Kunisue, Tatsuya; Kannan, Kurunthachalam] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA.
[Kunisue, Tatsuya; Kannan, Kurunthachalam] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Albany, NY 12201 USA.
[Chen, Zhen; Louis, Germaine M. Buck; Sundaram, Rajeshwari; Hediger, Mary L.; Sun, Liping] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, NIH, Rockville, MD 20852 USA.
[Kannan, Kurunthachalam] Harbin Inst Technol, IJRC PTS, State Key Lab Urban Water Resources & Environm, Harbin 150090, Peoples R China.
RP Kannan, K (reprint author), New York State Dept Hlth, Wadsworth Ctr, Empire State Plaza,POB 509, Albany, NY 12201 USA.
EM kkannan@wadsworth.org
RI Kunisue, Tatsuya/G-4171-2014;
OI Kunisue, Tatsuya/0000-0002-8167-1564; Sundaram,
Rajeshwari/0000-0002-6918-5002; Buck Louis, Germaine/0000-0002-1774-4490
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development (NICHD), National Institutes of Health [NO1-DK-6-3428,
NO1-DK-6-3427, 10001406-02]
FX This study was funded by the Intramural Research Program, Eunice Kennedy
Shriver National Institute of Child Health and Human Development
(NICHD), National Institutes of Health (contracts NO1-DK-6-3428,
NO1-DK-6-3427, 10001406-02).
NR 43
TC 88
Z9 91
U1 13
U2 76
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 17
PY 2012
VL 46
IS 8
BP 4624
EP 4632
DI 10.1021/es204415a
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 926SB
UT WOS:000302850300050
PM 22417702
ER
PT J
AU Wendler, D
AF Wendler, David
TI Consent for Research With Biological Samples: One-Time General Consent
Versus a Gift Model
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Editorial Material
ID INFORMED-CONSENT; GENETIC RESEARCH; TRIBE
C1 NIH, Ctr Clin, Dept Bioeth, Bethesda, MD 20892 USA.
RP Wendler, D (reprint author), NIH, Ctr Clin, Dept Bioeth, Bldg 10,Room 1C118, Bethesda, MD 20892 USA.
EM dwendler@nih.gov
NR 18
TC 3
Z9 3
U1 0
U2 2
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD APR 17
PY 2012
VL 156
IS 8
BP 596
EP U122
DI 10.7326/0003-4819-156-8-201204170-00008
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 930PO
UT WOS:000303151800019
PM 22508735
ER
PT J
AU Khademi, H
Malekzadeh, R
Pourshams, A
Jafari, E
Salahi, R
Semnani, S
Abaie, B
Islami, F
Nasseri-Moghaddam, S
Etemadi, A
Byrnes, G
Abnet, CC
Dawsey, SM
Day, NE
Pharoah, PD
Boffetta, P
Brennan, P
Kamangar, F
AF Khademi, Hooman
Malekzadeh, Reza
Pourshams, Akram
Jafari, Elham
Salahi, Rasool
Semnani, Shahryar
Abaie, Behrooz
Islami, Farhad
Nasseri-Moghaddam, Siavosh
Etemadi, Arash
Byrnes, Graham
Abnet, Christian C.
Dawsey, Sanford M.
Day, Nicholas E.
Pharoah, Paul D.
Boffetta, Paolo
Brennan, Paul
Kamangar, Farin
TI Opium use and mortality in Golestan Cohort Study: prospective cohort
study of 50 000 adults in Iran
SO BRITISH MEDICAL JOURNAL
LA English
DT Article
ID HIGH-RISK AREA; ESOPHAGEAL CANCER; SOCIOECONOMIC-STATUS; BLADDER-CANCER;
MORPHINE; RELIABILITY; POPULATION; METABOLISM; ADDICTION; CARCINOMA
AB Objectives To investigate the association between opium use and subsequent risk of death.
Design Prospective cohort study.
Setting The Golestan Cohort Study in north-eastern Iran collected detailed validated data on opium use and other exposures at baseline.
Participants were enrolled between January 2004 and June 2008 and were followed to May 2011, with a follow-up success rate of over 99%. Participants 50 045 participants aged 40-75 at baseline.
Main outcomes Mortality, all cause and major subcategories.
Results 17% (n=8487) of the participants reported opium use, with a mean duration of 12.7 years. During the follow-up period 2145 deaths were reported. The adjusted hazard ratio for all cause mortality associated with ever use of opium was 1.86 (95% confidence interval 1.68 to 2.06). Opium consumption was significantly associated with increased risks of deaths from several causes including circulatory diseases (hazard ratio 1.81) and cancer (1.61). The strongest associations were seen with deaths from asthma, tuberculosis, and chronic obstructive pulmonary disease (11.0, 6.22, and 5.44, respectively). After exclusion of people who self prescribed opium after the onset of major chronic illnesses, the associations remained strong with a dose-response relation.
Conclusion Opium users have an increased risk of death from multiple causes compared with non-users. Increased risks were also seen in people who used low amounts of opium for a long period and those who had no major illness before use.
C1 [Khademi, Hooman; Malekzadeh, Reza; Pourshams, Akram; Jafari, Elham; Abaie, Behrooz; Islami, Farhad; Nasseri-Moghaddam, Siavosh; Etemadi, Arash; Kamangar, Farin] Univ Tehran Med Sci, Digest Dis Res Ctr, Shariati Hosp, Tehran, Iran.
[Khademi, Hooman; Byrnes, Graham; Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
[Salahi, Rasool; Semnani, Shahryar] Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Iran.
[Islami, Farhad; Boffetta, Paolo] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA.
[Islami, Farhad; Boffetta, Paolo] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA.
[Etemadi, Arash; Abnet, Christian C.; Dawsey, Sanford M.; Kamangar, Farin] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Day, Nicholas E.; Pharoah, Paul D.] Univ Cambridge, Dept Oncol & Publ Hlth, Cambridge, England.
[Day, Nicholas E.; Pharoah, Paul D.] Univ Cambridge, Dept Primary Care, Cambridge, England.
[Boffetta, Paolo] Int Prevent Res Inst, Lyon, France.
[Kamangar, Farin] Morgan State Univ, Dept Publ Hlth Anal, Sch Community Hlth & Policy, Baltimore, MD 21239 USA.
RP Malekzadeh, R (reprint author), Univ Tehran Med Sci, Digest Dis Res Ctr, Shariati Hosp, Tehran, Iran.
EM malek@ams.ac.ir; brennan@iarc.fr
RI Abnet, Christian/C-4111-2015; Etemadi, Arash/C-1386-2016; Semnani,
Shahryar/N-2270-2016;
OI Abnet, Christian/0000-0002-3008-7843; Etemadi,
Arash/0000-0002-3458-1072; Semnani, Shahryar/0000-0002-8768-6142;
Malekzadeh, Reza/0000-0003-1043-3814
FU Tehran University of medical sciences [81/15]; Cancer Research UK
[C20/A5860]; NCI, National Institutes of Health; IARC; Social Security
Organization of Iran Golestan Branch
FX The Golestan Cohort Study was supported by Tehran University of medical
sciences (grant No: 81/15), Cancer Research UK (grant No: C20/A5860),
the Intramural Research Program of the NCI, National Institutes of
Health, and through various collaborative research agreements with the
IARC. The study has also received special support from the Social
Security Organization of Iran Golestan Branch.
NR 41
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Z9 39
U1 2
U2 10
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BRIT MED J
JI Br. Med. J.
PD APR 17
PY 2012
VL 344
AR e2502
DI 10.1136/bmj.e2502
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA 931CN
UT WOS:000303192100003
PM 22511302
ER
PT J
AU Gravotta, D
Carvajal-Gonzalez, JM
Mattera, R
Deborde, S
Banfelder, JR
Bonifacino, JS
Rodriguez-Boulan, E
AF Gravotta, Diego
Carvajal-Gonzalez, Jose Maria
Mattera, Rafael
Deborde, Sylvie
Banfelder, Jason R.
Bonifacino, Juan S.
Rodriguez-Boulan, Enrique
TI The Clathrin Adaptor AP-1A Mediates Basolateral Polarity
SO DEVELOPMENTAL CELL
LA English
DT Article
ID MANNOSE 6-PHOSPHATE RECEPTORS; TRANS-GOLGI NETWORK; EPITHELIAL-CELLS;
MDCK CELLS; STRUCTURAL EXPLANATION; TRANSFERRIN RECEPTOR; RECYCLING
ENDOSOMES; CYTOPLASMIC DOMAIN; MEMBRANE DOMAINS; PLASMA-MEMBRANE
AB Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking in epithelia. However, several epithelia lack AP-1B, and mice knocked out for AP-1B are viable, suggesting the existence of additional mechanisms that control basolateral polarity. Here, we demonstrate a distinct role of the ubiquitous clathrin adaptor AP-1A in basolateral protein sorting. Knockdown of AP-1A causes missorting of basolateral proteins in MDCK cells, but only after knockdown of AP-1B, suggesting that AP-1B can compensate for lack of AP-1A. AP-1A localizes predominantly to the TGN, and its knockdown promotes spillover of basolateral proteins into common recycling endosomes, the site of function of AP-1B, suggesting complementary roles of both adaptors in basolateral sorting. Yeast two-hybrid assays detect interactions between the basolateral signal of transferrin receptor and the medium subunits of both AP-1A and AP-1B. The basolateral sorting function of AP-1A reported here establishes AP-1 as a major regulator of epithelial polarity.
C1 [Gravotta, Diego; Carvajal-Gonzalez, Jose Maria; Deborde, Sylvie; Rodriguez-Boulan, Enrique] Weill Cornell Med Coll, Dept Ophthalmol, Margaret Dyson Vis Res Inst, New York, NY 10065 USA.
[Banfelder, Jason R.] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA.
[Rodriguez-Boulan, Enrique] Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA.
[Mattera, Rafael; Bonifacino, Juan S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
RP Gravotta, D (reprint author), Weill Cornell Med Coll, Dept Ophthalmol, Margaret Dyson Vis Res Inst, New York, NY 10065 USA.
EM dig2003@med.cornell.edu; boulan@med.cornell.edu
OI Deborde, Sylvie/0000-0002-6630-4029; Carvajal-Gonzalez, Jose
Maria/0000-0001-6576-830X; Bonifacino, Juan S./0000-0002-5673-6370
FU National Institutes of Health (NIH) [GM34108, EY08538]; Research to
Prevent Blindness Foundation; Dyson Foundation; EMBO; Eunice Kennedy
Shriver National Institute of Child Health and Human Development, NIH
FX We thank Dr. Alfonso Gonzalez for reading and commenting on the
manuscript. This work was supported by National Institutes of Health
(NIH) grants GM34108 and EY08538 to E.R.-B., by funds from Research to
Prevent Blindness Foundation, by the Dyson Foundation, and by an EMBO
Postdoctoral Fellowship to J.M.C.-G. R.M. and J.S.B. were supported by
the Intramural Program of the Eunice Kennedy Shriver National Institute
of Child Health and Human Development, NIH. We thank B. Lelouvier
(National Heart, Lung, and Blood Institute, NIH) for providing an ImageJ
plugin for automated analysis of confocal images; Drs. Andres Perez-Bay,
Ryan Schreiner, and Susana Salvarezza for colocalization experiments;
and Luciana Gravotta, M.A., for help with statistical analyses.
NR 59
TC 75
Z9 76
U1 0
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1534-5807
J9 DEV CELL
JI Dev. Cell
PD APR 17
PY 2012
VL 22
IS 4
BP 811
EP 823
DI 10.1016/j.devcel.2012.02.004
PG 13
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 929XQ
UT WOS:000303099400015
PM 22516199
ER
PT J
AU Cha, YR
Fujita, M
Butler, M
Isogai, S
Kochhan, E
Siekmann, AF
Weinstein, BM
AF Cha, Young Ryun
Fujita, Misato
Butler, Matthew
Isogai, Sumio
Kochhan, Eva
Siekmann, Arndt F.
Weinstein, Brant M.
TI Chemokine Signaling Directs Trunk Lymphatic Network Formation along the
Preexisting Blood Vasculature
SO DEVELOPMENTAL CELL
LA English
DT Article
ID INHIBITS SPROUTING ANGIOGENESIS; ENDOTHELIAL-GROWTH-FACTOR; DEVELOPING
ZEBRAFISH; LATERAL-LINE; IN-VIVO; TRANSGENIC ZEBRAFISH; CXCR4
ANTAGONISTS; TISSUE MIGRATION; CELL-MIGRATION; RECEPTOR CXCR4
AB The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, whereas chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain-of-function studies in zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical coalignment of lymphatic and blood vessels.
C1 [Cha, Young Ryun; Fujita, Misato; Butler, Matthew; Weinstein, Brant M.] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA.
[Isogai, Sumio] Iwate Med Univ, Dept Anat, Sch Med, Morioka, Iwate 0208505, Japan.
[Kochhan, Eva; Siekmann, Arndt F.] Max Planck Inst Mol Biomed, D-48149 Munster, Germany.
RP Weinstein, BM (reprint author), NICHHD, Mol Genet Lab, NIH, 6B-309,6 Ctr Dr, Bethesda, MD 20892 USA.
EM bw96w@nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development and National Institutes of Health; Leducq Foundation; Max
Planck Society; Deutsche Forschungsgemeinschaft [SI 1374/3-1]; ERC
[260794-ZebrafishAngio]
FX We thank members of the Weinstein laboratory for technical help and
critical suggestions. We would like to thank Dr. Nobutaka Fujii for
providing the Cxcr4 inhibitor (TF10416). We are also grateful to James
Chen for the gift of GV-EcRF' plasmid. This research was supported by
intramural program of the Eunice Kennedy Shriver National Institute of
Child Health and Human Development and National Institutes of Health and
by the Leducq Foundation. A.F.S. was supported by the Max Planck
Society, a grant from the Deutsche Forschungsgemeinschaft (SI 1374/3-1),
and an ERC starting grant (260794-ZebrafishAngio).
NR 64
TC 42
Z9 42
U1 0
U2 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1534-5807
J9 DEV CELL
JI Dev. Cell
PD APR 17
PY 2012
VL 22
IS 4
BP 824
EP 836
DI 10.1016/j.devcel.2012.01.011
PG 13
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 929XQ
UT WOS:000303099400016
PM 22516200
ER
PT J
AU Valley, CT
Porter, DF
Qiu, C
Campbell, ZT
Hall, TMT
Wickens, M
AF Valley, Cary T.
Porter, Douglas F.
Qiu, Chen
Campbell, Zachary T.
Hall, Traci M. Tanaka
Wickens, Marvin
TI Patterns and plasticity in RNA-protein interactions enable recruitment
of multiple proteins through a single site
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE mRNA turnover; RNA regulation; translation; 3 ' UTR elements
ID PUMILIO-HOMOLOGY DOMAIN; YEAST 3-HYBRID SYSTEM; ELEGANS PUF PROTEIN;
MESSENGER-RNA; BINDING PROTEIN; CAENORHABDITIS-ELEGANS; MITOCHONDRIAL
BIOGENESIS; WIDE IDENTIFICATION; IN-VIVO; FAMILY
AB mRNA control hinges on the specificity and affinity of proteins for their RNA binding sites. Regulatory proteins must bind their own sites and reject even closely related noncognate sites. In the PUF [Pumilio and fem-3 binding factor (FBF)] family of RNA binding proteins, individual proteins discriminate differences in the length and sequence of binding sites, allowing each PUF to bind a distinct battery of mRNAs. Here, we show that despite these differences, the pattern of RNA interactions is conserved among PUF proteins: the two ends of the PUF protein make critical contacts with the two ends of the RNA sites. Despite this conserved "two-handed" pattern of recognition, the RNA sequence is flexible. Among the binding sites of yeast Puf4p, RNA sequence dictates the pattern in which RNA bases are flipped away from the binding surface of the protein. Small differences in RNA sequence allow new modes of control, recruiting Puf5p in addition to Puf4p to a single site. This embedded information adds a new layer of biological meaning to the connections between RNA targets and PUF proteins.
C1 [Campbell, Zachary T.; Wickens, Marvin] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.
[Valley, Cary T.] Univ Wisconsin, Grad Program Cellular & Mol Biol, Madison, WI 53706 USA.
[Porter, Douglas F.] Univ Wisconsin, Integrated Program Biochem, Madison, WI 53706 USA.
[Qiu, Chen; Hall, Traci M. Tanaka] Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
RP Wickens, M (reprint author), Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.
EM wickens@biochem.wisc.edu
FU National Institutes of Health [GM50942, GM095169]; National Institute of
Environmental Health Sciences; National Institutes of Health/National
Institute of General Medical Sciences [5T32GM08349]; US Department of
Energy, Office of Science, Office of Basic Energy Sciences
[W-31-109-Eng-38]
FX We thank Dr. Lars Pedersen and the staff at the Southeast Regional
Collaborative Access Team beamline for help with X-ray data collection
and Dr. Vanderploeg for help with figures. Data were collected at
Southeast Regional Collaborative Access Team 22-ID beamline at the
Advanced Photon Source, Argonne National Laboratory. Supporting
institutions may be found at www.ser-cat.org/members.html. This work was
supported by Grants GM50942 and GM095169 from the National Institutes of
Health (to M. W. and Z.T.C. respectively), by a grant from the
Intramural Research Program of the National Institute of Environmental
Health Sciences (to T. M. T. H.), and by National Institutes of
Health/National Institute of General Medical Sciences Grant 5T32GM08349
(to D. F. P.). Use of the Advanced Photon Source was supported by the US
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract W-31-109-Eng-38.
NR 50
TC 19
Z9 21
U1 1
U2 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6054
EP 6059
DI 10.1073/pnas.1200521109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100036
PM 22467831
ER
PT J
AU Malik, M
Jividen, K
Padmakumar, VC
Cataisson, C
Li, LW
Lee, J
Howard, OMZ
Yuspa, SH
AF Malik, Mariam
Jividen, Kasey
Padmakumar, V. C.
Cataisson, Christophe
Li, Luowei
Lee, Jessica
Howard, O. M. Zack
Yuspa, Stuart H.
TI Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear
translocation regulates macrophage deactivation
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE protein nitrosylation; IL-1beta; phagocytosis
ID GROWTH-FACTOR-BETA; NITRIC-OXIDE; RECEPTOR EXPRESSION; MOUSE
MACROPHAGES; PROTEIN CLIC4; ION CHANNEL; ACTIVATION; INFLAMMATION;
LIPOPOLYSACCHARIDE; MTCLIC/CLIC4
AB Nuclear translocation of cytosolic CLIC4 is an essential feature of its proapoptotic and prodifferentiation functions. Here we demonstrate that CLIC4 is induced concurrently with inducible nitric oxide synthase (iNOS) and S-nitrosylated in proinflammatory peritoneal macrophages. Chemical inhibition or genetic ablation of iNOS inhibits S-nitrosylation and nuclear translocation of CLIC4. In macrophages, iNOS-induced nuclear CLIC4 coincides with the proto anti-inflammatory transition of the cells because IL-1 beta and CXCL1 mRNA remain elevated in CLIC4 and iNOS knockout macrophages at late time points, whereas TNF alpha mRNA is elevated only in the iNOS knockout macrophages. Active IL-1 beta remains elevated in CLIC4 knockout macrophages and in macrophages in which CLIC4 nuclear translocation is prevented by the NOS inhibitor L-NAME. Moreover, overexpression of nuclear-targeted CLIC4 down-regulates IL-1 beta in stimulated macrophages. In mice, genetically null for CLIC4, the number of phagocytosing macrophages stimulated by LPS is reduced. Thus, iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program.
C1 [Malik, Mariam; Jividen, Kasey; Padmakumar, V. C.; Cataisson, Christophe; Li, Luowei; Lee, Jessica; Yuspa, Stuart H.] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA.
[Howard, O. M. Zack] NCI, Mol Immunoregulat Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Yuspa, SH (reprint author), NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA.
EM yuspas@mail.nih.gov
RI Howard, O M Zack/B-6117-2012;
OI Howard, O M Zack/0000-0002-0505-7052; Jividen, Kasey/0000-0003-1022-5038
FU National Cancer Institute; National Institutes of Health
FX We thank Kathleen Noer and Roberta Matthai of the Cancer and
Inflammation Program Fluorescence-Activated Cell Sorter Core for
technical assistance in immune cell sorting; Susan Garfield and the
National Cancer Institute Confocal Core for microscopy assistance; and
Marta Custer for maintenance of animal colonies. We also thank Anjali
Shukla and Francesca Mascia for helpful suggestions. This work was
supported by the intramural program of the National Cancer Institute and
the National Institutes of Health.
NR 35
TC 13
Z9 13
U1 2
U2 7
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6130
EP 6135
DI 10.1073/pnas.1201351109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100049
PM 22474389
ER
PT J
AU Yu, P
Steel, JC
Zhang, ML
Morris, JC
Waitz, R
Fasso, M
Allison, JP
Waldmann, TA
AF Yu, Ping
Steel, Jason C.
Zhang, Meili
Morris, John C.
Waitz, Rebecca
Fasso, Marcella
Allison, James P.
Waldmann, Thomas A.
TI Simultaneous inhibition of two regulatory T-cell subsets enhanced
Interleukin-15 efficacy in a prostate tumor model
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID GROWTH-FACTOR-BETA; CUTTING EDGE; LUNG-CANCER; CTLA-4; IL-10; TOLERANCE;
PD-1; PROLIFERATION; RESPONSES; IMMUNITY
AB IL-15 has potential as an immunotherapeutic agent for cancer treatment because of its ability to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity. However, its effectiveness may be limited by negative immunological checkpoints that attenuate immune responses. Recently a clinical trial of IL-15 in cancer immunotherapy was initiated. Finding strategies to conquer negative regulators and enhance efficacy of IL-15 is critical and meaningful for such clinical trials. In a preclinical study, we evaluated IL-15 combined with antibodies to block negative immune regulator cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death ligand 1 (PD-L1) in an established murine transgenic adenocarcinoma of mouse prostate (TRAMP)-C2 prostate tumor model. IL-15 treatment resulted in a significant prolongation of survival in tumor-bearing animals. Coadministration of anti-PD-L1 or anti-CTLA-4 singly with IL-15 did not improve animal survival over that of IL-15 alone. However, simultaneous administration of IL-15 with anti-CTLA-4 and anti-PD-L1 was associated with increased numbers of tumor antigen-specific tetramer-positive CD8 T cells, increased CD8T-cell tumor lytic activity, augmented antigen-specific IFN-gamma release, decreased rates of tumor growth, and improved animal survival compared with IL-15 alone. Furthermore, triple combination therapy was associated with inhibition of suppressive functions of CD4(+)CD25(+) regulatory T cells and CD8(+)CD122(+) regulatory T cells. Thus, simultaneous blockade of CTLA-4 and PD-L1 protected CD4 and/or CD8 T-cell activity from these regulatory T cells. Combining the immune stimulatory properties of IL-15 with simultaneous removal of two critical immune inhibitory checkpoints, we showed enhancement of immune responses, leading to increased antitumor activity.
C1 [Yu, Ping; Steel, Jason C.; Zhang, Meili; Morris, John C.; Waldmann, Thomas A.] NCI, Metab Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Steel, Jason C.; Morris, John C.] Univ Cincinnati, Div Hematol Oncol, Cincinnati, OH 45267 USA.
[Zhang, Meili] NCI, Lab Anim Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA.
[Waitz, Rebecca; Allison, James P.] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10065 USA.
[Fasso, Marcella] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94193 USA.
RP Waldmann, TA (reprint author), NCI, Metab Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
EM tawald@helix.nih.gov
RI Steel, Jason/D-1805-2013
OI Steel, Jason/0000-0003-3608-7542
FU National Institutes of Health, National Cancer Institute, Center for
Cancer Research; Howard Hughes Medical Institute, Ludwig Center of
Cancer Immunotherapy, Prostate Cancer Foundation
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Cancer Institute, Center for
Cancer Research (P.Y., J.C.S., M.Z., J.C.M., and T. A. W.). R. W., M.
F., and J.P.A. were funded by the Howard Hughes Medical Institute,
Ludwig Center of Cancer Immunotherapy, Prostate Cancer Foundation.
NR 34
TC 27
Z9 28
U1 1
U2 10
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6187
EP 6192
DI 10.1073/pnas.1203479109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100059
PM 22474386
ER
PT J
AU Schoch, CL
Seifert, KA
Huhndorf, S
Robert, V
Spouge, JL
Levesque, CA
Chen, W
Bolchacova, E
Voigt, K
Crous, PW
Miller, AN
Wingfield, MJ
Aime, MC
An, KD
Bai, FY
Barreto, RW
Begerow, D
Bergeron, MJ
Blackwell, M
Boekhout, T
Bogale, M
Boonyuen, N
Burgaz, AR
Buyck, B
Cai, L
Cai, Q
Cardinali, G
Chaverri, P
Coppins, BJ
Crespo, A
Cubas, P
Cummings, C
Damm, U
de Beer, ZW
de Hoog, GS
Del-Prado, R
Dentinger B
Dieguez-Uribeondo, J
Divakar, PK
Douglas, B
Duenas, M
Duong, TA
Eberhardt, U
Edwards, JE
Elshahed, MS
Fliegerova, K
Furtado, M
Garcia, MA
Ge, ZW
Griffith, GW
Griffiths, K
Groenewald, JZ
Groenewald, M
Grube, M
Gryzenhout, M
Guo, LD
Hagen, F
Hambleton, S
Hamelin, RC
Hansen, K
Harrold, P
Heller, G
Herrera, G
Hirayama, K
Hirooka, Y
Ho, HM
Hoffmann, K
Hofstetter, V
Hognabba, F
Hollingsworth, PM
Hong, SB
Hosaka, K
Houbraken, J
Hughes, K
Huhtinen, S
Hyde, KD
James, T
Johnson, EM
Johnson, JE
Johnston, PR
Jones, EB
Kelly, LJ
Kirk, PM
Knapp, DG
Koljalg, U
Kovacs GM
Kurtzman, CP
Landvik, S
Leavitt, SD
Liggenstoffer, AS
Liimatainen, K
Lombard, L
Luangsa-Ard, JJ
Lumbsch, HT
Maganti, H
Maharachchikumbura, SS
Martin, MP
May, TW
McTaggart, AR
Methven, AS
Meyer, W
Moncalvo, JM
Mongkolsamrit, S
Nagy, LG
Nilsson, RH
Niskanen, T
Nyilasi, I
Okada, G
Okane, I
Olariaga, I
Otte, J
Papp, T
Park, D
Petkovits, T
Pino-Bodas, R
Quaedvlieg, W
Raja, HA
Redecker, D
Rintoul T
Ruibal, C
Sarmiento-Ramirez, JM
Schmitt, I
Schussler, A
Shearer, C
Sotome, K
Stefani, FO
Stenroos, S
Stielow, B
Stockinger, H
Suetrong, S
Suh, SO
Sung, GH
Suzuki, M
Tanaka, K
Tedersoo, L
Telleria, MT
Tretter, E
Untereiner, WA
Urbina, H
Vagvolgyi, C
Vialle, A
Vu, TD
Walther, G
Wang, QM
Wang, Y
Weir, BS
Weiss, M
White, MM
Xu, J
Yahr, R
Yang, ZL
Yurkov, A
Zamora, JC
Zhang, N
Zhuang, WY
Schindel, D
AF Schoch, Conrad L.
Seifert, Keith A.
Huhndorf, Sabine
Robert, Vincent
Spouge, John L.
Levesque, C. Andre
Chen, Wen
Bolchacova, E.
Voigt, K.
Crous, P.W.
Miller, A.N.
Wingfield, M.J.
Aime, M.C.
An, K.D.
Bai, F.Y
Barreto, R.W.
Begerow, D.
Bergeron, MJ
Blackwell, M
Boekhout, T
Bogale, M
Boonyuen, N
Burgaz, AR
Buyck, B
Cai, L
Cai, Q
Cardinali, G
Chaverri, P
Coppins, BJ
Crespo, A
Cubas P, P.
Cummings, C
Damm, U.
de Beer, Z.W.
de Hoog, G.S.
Del-Prado, R
Dentinger, B.
Dieguez-Uribeondo, J
Divakar, PK
Douglas, B
Duenas, M
Duong, T.A.
Eberhardt, U
Edwards, J.E.
Elshahed, MS
Fliegerova, K
Furtado, M.
Garcia, M.A.
Ge, Z.W.
Griffith, GW
Griffiths, K
Groenewald, JZ
Groenewald, M
Grube, M
Gryzenhout, M
Guo, LD
Hagen, F
Hambleton, S
Hamelin, RC
Hansen, K
Harrold, P
Heller, G
Herrera, G
Hirayama, K
Hirooka, Y
Ho, H.M.
Hoffmann, K.
Hofstetter, V
Hognabba, F.
Hollingsworth, P.M.
Hong, S.B.
Hosaka, K
Houbraken, J
Hughes, K
Huhtinen, S.
Hyde, KD
James, T
Johnson, EM
Johnson, JE
Johnston, PR
Jones, EB
Kelly, L.J.
Kirk, PM
Knapp, DG
Koljalg, U
Kovacs, GM
Kurtzman, CP
Landvik, S
Leavitt, SD
Liggenstoffer, AS
Liimatainen, K.
Lombard, L.
Luangsa-Ard, J.J.
Lumbsch, HT
Maganti H
Maharachchikumbura, SS
Martin, MP
May, TW
McTaggart, A.R.
Methven, AS
Meyer, W
Moncalvo, J.M.
Mongkolsamrit, S
Nagy, L.G.
Nilsson, RH
Niskanen, T
Nyilasi, I
Okada, G
Okane, I
Olariaga, I
Otte, J.
Papp, T
Park, D
Petkovits, T
Pino-Bodas, R.
Quaedvlieg, W
Raja, H.A.
Redecker, D.
Rintoul, T.
Ruibal, C.
Sarmiento-Ramirez, J.M.
Schmitt, I
Schussler, A.
Shearer, C.
Sotome, K.
Stefani, FO
Stenroos, S.
Stielow, B.
Stockinger, H.
Suetrong, S.
Suh, S.O.
Sung, G.H.
Suzuki, M.
Tanaka, K.
Tedersoo, L.
Telleria, MT
Tretter, E.
Untereiner, W.A.
Urbina, H.
Vagvolgyi, C
Vialle, A
Vu, T.D.
Walther, G.
Wang, Q.M.
Wang, Y.
Weir, B.S.
Weiss, M.
White, M.M.
Xu, J.
Yahr, R.
Yang, Z.L.
Yurkov, A.
Zamora, J.C.
Zhang, N.
Zhuang, W.Y.
Schindel, D
CA Fungal Barcoding Consortium
TI Nuclear ribosomal internal transcribed spacer (ITS) region as a
universal DNA barcode marker for Fungi
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE DNA barcoding; fungal biodiversity
ID ARBUSCULAR MYCORRHIZAL FUNGI; PHYLOGENETIC-RELATIONSHIPS;
BASIDIOMYCETOUS YEASTS; INTRAGENOMIC VARIATION; ECTOMYCORRHIZAL FUNGI;
SPECIES RECOGNITION; SEQUENCE-ANALYSIS; RPB1 SEQUENCES; RDNA; SUBUNIT
AB Six DNA regions were evaluated as potential DNA barcodes for Fungi, the second largest kingdom of eukaryotic life, by a multinational, multilaboratory consortium. The region of the mitochondrial cytochrome c oxidase subunit 1 used as the animal barcode was excluded as a potential marker, because it is difficult to amplify in fungi, often includes large introns, and can be insufficiently variable. Three subunits from the nuclear ribosomal RNA cistron were compared together with regions of three representative protein-coding genes (largest subunit of RNA polymerase II, second largest subunit of RNA polymerase II, and minichromosome maintenance protein). Although the protein-coding gene regions often had a higher percent of correct identification compared with ribosomal markers, low PCR amplification and sequencing success eliminated them as candidates for a universal fungal barcode. Among the regions of the ribosomal cistron, the internal transcribed spacer (ITS) region has the highest probability of successful identification for the broadest range of fungi, with the most clearly defined barcode gap between inter-and intraspecific variation. The nuclear ribosomal large subunit, a popular phylogenetic marker in certain groups, had superior species resolution in some taxonomic groups, such as the early diverging lineages and the ascomycete yeasts, but was otherwise slightly inferior to the ITS. The nuclear ribosomal small subunit has poor species-level resolution in fungi. ITS will be formally proposed for adoption as the primary fungal barcode marker to the Consortium for the Barcode of Life, with the possibility that supplementary barcodes may be developed for particular narrowly circumscribed taxonomic groups.
C1 [Schoch, Conrad L.; Spouge, John L.; Fungal Barcoding Consortium] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
[Seifert, Keith A.; Levesque, C. Andre; Chen, Wen] Agr & Agri Food Canada, Biodivers Mycol & Microbiol, Ottawa, ON K1A 0C6, Canada.
[Huhndorf, Sabine] Field Museum, Dept Bot, Chicago, IL 60605 USA.
[Robert, Vincent] Cent Bur Schimmelcultures Fungal Biodivers Ctr CB, NL-3508 AD Utrecht, Netherlands.
RP Schoch, CL (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
EM schoch2@ncbi.nlm.nih.gov; Keith.Seifert@AGR.GC.CA
RI Quaedvlieg, William/C-9449-2013; Yurkov, Andrey/E-7854-2011; Cai,
Lei/D-1589-2013; CARDINALI, GIANLUIGI/B-8622-2011; McTaggart,
Alistair/A-8871-2014; May, Tom/C-2460-2014; Fliegerova,
Katerina/G-7196-2014; CAI, LEI/K-7226-2014; Hagen, Ferry/B-9044-2009;
Meyer, Wieland/G-1204-2015; Telleria, M. Teresa/H-4928-2015; Duenas,
Margarita/H-4944-2015; SchuSSler, Arthur/F-1681-2011; Groenewald,
Johannes/F-4667-2011; Crous, Pedro/H-1489-2012; Tedersoo,
Leho/H-3541-2012; Weir, Bevan/B-5057-2008; Duong, Tuan/I-9432-2012;
Schoch, Conrad/J-4825-2012; Lumbsch, Thorsten/K-3573-2012; Zhang,
Ning/K-3046-2012; Wingfield, Michael/A-9473-2008; Lombard,
Lorenzo/B-2042-2010; Boonyuen, Nattawut/F-2167-2011; WeiSS,
Michael/F-6206-2012; Groenewald, Marizeth/G-4976-2012; de Beer, Z.
Wilhelm/B-6353-2008; Knapp, Daniel/C-9481-2013; Maharachchikumbura,
Sajeewa/C-9403-2013; Garcia, Miguel Angel/N-6275-2016; Martin, Maria
/H-8069-2012; Divakar, Pradeep/E-5603-2014;
OI Stenroos, Soili/0000-0003-0331-792X; Grube, Martin/0000-0001-6940-5282;
Nilsson, Henrik/0000-0002-8052-0107; Urbina, Hector/0000-0002-5570-4537;
DEL PRADO, RUTH/0000-0002-7497-2510; Wang, Yan/0000-0002-5950-8904;
Zamora, Juan Carlos/0000-0002-9243-2999; Ruibal Villasenor,
Constantino/0000-0003-3494-7051; May, Tom/0000-0003-2214-4972;
McTaggart, Alistair/0000-0002-0996-1313; Raja,
Huzefa/0000-0002-0824-9463; Yurkov, Andrey/0000-0002-1072-5166;
CARDINALI, GIANLUIGI/0000-0002-4522-7925; McTaggart,
Alistair/0000-0002-3681-7632; CAI, LEI/0000-0002-8131-7274; Hagen,
Ferry/0000-0002-5622-1916; Meyer, Wieland/0000-0001-9933-8340; Telleria,
M. Teresa/0000-0002-9876-6914; Duenas, Margarita/0000-0003-0621-8003;
Crous, Pedro/0000-0001-9085-8825; Weir, Bevan/0000-0003-2580-0701;
Duong, Tuan/0000-0001-5110-1854; Lumbsch, Thorsten/0000-0003-1512-835X;
Zhang, Ning/0000-0003-0755-2505; Lombard, Lorenzo/0000-0002-5942-5375;
WeiSS, Michael/0000-0002-4869-9186; Groenewald,
Marizeth/0000-0003-0835-5925; de Beer, Z. Wilhelm/0000-0001-9758-8987;
Garcia, Miguel Angel/0000-0002-0366-043X; Martin, Maria
/0000-0002-1235-4418; Divakar, Pradeep/0000-0002-0300-0124;
Hollingsworth, Peter/0000-0003-0602-0654
FU Alfred P. Sloan Foundation; National Library of Medicine at the National
Institutes of Health; Life Technologies Corporation
FX We thank David L. Hawksworth, Martin Bidartondo, and numerous other
colleagues for critical comments. This work was organized under the
Fungal Working Group of the Consortium for the Barcode of Life (CBOL),
which provided support from its funding from the Alfred P. Sloan
Foundation. Support was also provided by the Intramural Research Program
of the National Library of Medicine at the National Institutes of
Health, Life Technologies Corporation, and the individual funders to
authors who provided sequences for our analysis. Publication charges
were provided by the International Barcode of Life Network from Genome
Canada through the Ontario Genomics Institute.
NR 83
TC 1074
Z9 1147
U1 65
U2 607
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6241
EP 6246
DI 10.1073/pnas.1117018109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100068
PM 22454494
ER
PT J
AU Lovatt, D
Xu, QW
Liu, W
Takano, T
Smith, NA
Schnermann, J
Tieu, K
Nedergaard, M
AF Lovatt, Ditte
Xu, Qiwu
Liu, Wei
Takano, Takahiro
Smith, Nathan A.
Schnermann, Jurgen
Tieu, Kim
Nedergaard, Maiken
TI Neuronal adenosine release, and not astrocytic ATP release, mediates
feedback inhibition of excitatory activity
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE purinergic signaling; purine; glia; calcium signaling
ID NUCLEOSIDE TRANSPORTERS; SYNAPTIC-TRANSMISSION; DEPENDENT RELEASE;
INDUCED SEIZURES; NERVOUS-SYSTEM; A(1) RECEPTOR; BRAIN; HIPPOCAMPUS;
ACTIVATION; STIMULATION
AB Adenosine is a potent anticonvulsant acting on excitatory synapses through A1 receptors. Cellular release of ATP, and its subsequent extracellular enzymatic degradation to adenosine, could provide a powerful mechanism for astrocytes to control the activity of neural networks during high-intensity activity. Despite adenosine's importance, the cellular source of adenosine remains unclear. We report here that multiple enzymes degrade extracellular ATP in brain tissue, whereas only Nt5e degrades AMP to adenosine. However, endogenous A1 receptor activation during cortical seizures in vivo or heterosynaptic depression in situ is independent of Nt5e activity, and activation of astrocytic ATP release via Ca2+ photolysis does not trigger synaptic depression. In contrast, selective activation of postsynaptic CA1 neurons leads to release of adenosine and synaptic depression. This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity.
C1 [Lovatt, Ditte; Xu, Qiwu; Liu, Wei; Takano, Takahiro; Smith, Nathan A.; Tieu, Kim; Nedergaard, Maiken] Univ Rochester, Med Ctr, Ctr Translat Neuromed, Dept Neurosurg, Rochester, NY 14642 USA.
[Lovatt, Ditte; Xu, Qiwu; Liu, Wei; Takano, Takahiro; Smith, Nathan A.; Tieu, Kim; Nedergaard, Maiken] Univ Rochester, Med Ctr, Ctr Translat Neuromed, Dept Neurol, Rochester, NY 14642 USA.
[Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD 20892 USA.
RP Lovatt, D (reprint author), Univ Rochester, Med Ctr, Ctr Translat Neuromed, Dept Neurosurg, Rochester, NY 14642 USA.
EM lovatt@upenn.edu; nedergaard@urmc.rochester.edu
RI Tieu, Kim/F-5426-2012
OI Tieu, Kim/0000-0001-6606-4371
FU G. Harold and Leila Y. Mathers Charitable Foundation; Adelson Medical
Research Foundation; National Institutes of Health [NS075177, NS078304,
F31NS073390]
FX We thank Herbert Zimmermann, Marisa Cotrina, and Takumi Fujita for
valuable suggestions to this manuscript. This work was supported by the
G. Harold and Leila Y. Mathers Charitable Foundation, the Adelson
Medical Research Foundation, and the National Institutes of Health.
Grants NS075177 and NS078304 (to M.N.) and F31NS073390 (to N.A.S.).
NR 49
TC 111
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U1 2
U2 14
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6265
EP 6270
DI 10.1073/pnas.1120997109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100072
PM 22421436
ER
PT J
AU Rissman, RA
Staup, MA
Lee, AR
Justice, NJ
Rice, KC
Vale, W
Sawchenko, PE
AF Rissman, Robert A.
Staup, Michael A.
Lee, Allyson Roe
Justice, Nicholas J.
Rice, Kenner C.
Vale, Wylie
Sawchenko, Paul E.
TI Corticotropin-releasing factor receptor-dependent effects of repeated
stress on tau phosphorylation, solubility, and aggregation
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE neurofibrillary tangles; western blot; pathology; electron microscopy
ID PAIRED HELICAL FILAMENTS; TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE;
IN-VIVO; COGNITIVE DEFICITS; CRF RECEPTORS; MICE; TAUOPATHY; PATHOLOGY;
SYSTEM
AB Exposure and/or sensitivity to stress have been implicated as conferring risk for development of Alzheimer's disease (AD). Although the basis for such a link remains unclear, we previously reported differential involvement of corticotropin-releasing factor receptor (CRFR) 1 and 2 in acute stress-induced tau phosphorylation (tau-P) and solubility in the hippocampus. Here we examined the role of CRFRs in tau-P induced by repeated stress and the structural manifestations of altered tau solubility. Robust tau-P responses were seen in WT and CRFR2 null mice exposed to repeated stress, which were sustained at even 24 h after the final stress exposure. A portion of phosphorylated tau in these mice was sequestered in detergent-soluble cellular fractions. In contrast, CRFR1 and CRFR double-KO mice did not exhibit repeated stress-induced alterations in tau-P or solubility. Similarly, treatment with CRFR1 antagonist attenuated repeated stress-induced tau-P. Using histochemical approaches in a transgenic CRFR1 reporter mouse line, we found substantial overlap between hippocampal CRFR1 expression and cells positive for phosphorylated tau after exposure to repeated stress. Ultrastructural analysis of negatively stained extracts from WT and CRFR2 null mice identified globular aggregates that displayed positive immunogold labeling for tau-P, as well as conformational changes in tau (MC1) seen in early AD. Given that repeated stress exposure results in chronic increases in hippocampal tau-P and its sequestration in an insoluble (and potentially prepathogenic) form, our data may define a link between stress and an AD-related pathogenic mechanism.
C1 [Rissman, Robert A.; Staup, Michael A.; Lee, Allyson Roe] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
[Justice, Nicholas J.] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA.
[Rice, Kenner C.] Natl Inst Drug Abuse & Alcohol Abuse & Alcoholism, Chem Biol Res Branch, NIH, Bethesda, MD 20892 USA.
[Vale, Wylie] Salk Inst Biol Studies, Peptide Biol Lab, La Jolla, CA 92037 USA.
[Sawchenko, Paul E.] Salk Inst Biol Studies, Neuronal Struct & Funct Lab, La Jolla, CA 92037 USA.
RP Rissman, RA (reprint author), Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
EM rrissman@ucsd.edu
FU National Institutes of Health [AG032755, DK026741, AG010483];
Alzheimer's Art Quilt Initiative; Alzheimer's Association; Foundation
for Medical Research; Shiley-Marcos Alzheimer's Disease Research Center
at University of California at San Diego [AG005131]
FX We dedicate this paper to the memory of Dr. Wylie Vale, long time mentor
and friend, whose leadership in the area of CRF and stress biology made
this work possible, and whose colleagueship made it a joy. We thank Drs.
S. Wagner and E. Masliah (University of California at San Diego) for
helpful discussions and Dr. P. Davies for generously providing tau
antibodies MC1 and PHF-1. This work was supported by National Institutes
of Health Grants AG032755, DK026741, and AG010483; the Alzheimer's Art
Quilt Initiative; the Alzheimer's Association; the Foundation for
Medical Research; and the Shiley-Marcos Alzheimer's Disease Research
Center at University of California at San Diego through Pilot Grant
AG005131. W. V. was a senior investigator at the Foundation for Medical
Research, and P. E. S. is a senior investigator at the Foundation for
Medical Research.
NR 54
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U1 0
U2 15
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2012
VL 109
IS 16
BP 6277
EP 6282
DI 10.1073/pnas.1203140109
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 931UZ
UT WOS:000303246100074
PM 22451915
ER
PT J
AU Rogozin, IB
Carmel, L
Csuros, M
Koonin, EV
AF Rogozin, Igor B.
Carmel, Liran
Csuros, Miklos
Koonin, Eugene V.
TI Origin and evolution of spliceosomal introns
SO BIOLOGY DIRECT
LA English
DT Review
DE Intron sliding; Intron gain; Intron loss; Spliceosome; Splicing signals;
Evolution of exon/intron structure; Alternative splicing; Phylogenetic
trees; Mobile domains; Eukaryotic ancestor
ID MESSENGER-RNA EXPORT; HIGHLY EXPRESSED GENES; CHORDATE
OIKOPLEURA-DIOICA; EXONIC SPLICING ENHANCERS; HUMAN HOUSEKEEPING GENES;
CONSERVED NONCODING DNA; RIBOSOMAL-PROTEIN GENES; EUKARYOTIC EVOLUTION;
MOLECULAR EVOLUTION; SELECTIVE CONSTRAINTS
AB Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing, intensive debate. The introns early concept, later rebranded 'introns first' held that protein-coding genes were interrupted by numerous introns even at the earliest stages of life's evolution and that introns played a major role in the origin of proteins by facilitating recombination of sequences coding for small protein/peptide modules. The introns-late concept held that introns emerged only in eukaryotes and new introns have been accumulating continuously throughout eukaryotic evolution. Analysis of orthologous genes from completely sequenced eukaryotic genomes revealed numerous shared intron positions in orthologous genes from animals and plants and even between animals, plants and protists, suggesting that many ancestral introns have persisted since the last eukaryotic common ancestor (LECA). Reconstructions of intron gain and loss using the growing collection of genomes of diverse eukaryotes and increasingly advanced probabilistic models convincingly show that the LECA and the ancestors of each eukaryotic supergroup had intron-rich genes, with intron densities comparable to those in the most intron-rich modern genomes such as those of vertebrates. The subsequent evolution in most lineages of eukaryotes involved primarily loss of introns, with only a few episodes of substantial intron gain that might have accompanied major evolutionary innovations such as the origin of metazoa. The original invasion of self-splicing Group II introns, presumably originating from the mitochondrial endosymbiont, into the genome of the emerging eukaryote might have been a key factor of eukaryogenesis that in particular triggered the origin of endomembranes and the nucleus. Conversely, splicing errors gave rise to alternative splicing, a major contribution to the biological complexity of multicellular eukaryotes. There is no indication that any prokaryote has ever possessed a spliceosome or introns in protein-coding genes, other than relatively rare mobile self-splicing introns. Thus, the introns-first scenario is not supported by any evidence but exon-intron structure of protein-coding genes appears to have evolved concomitantly with the eukaryotic cell, and introns were a major factor of evolution throughout the history of eukaryotes. This article was reviewed by I. King Jordan, Manuel Irimia (nominated by Anthony Poole), Tobias Mourier (nominated by Anthony Poole), and Fyodor Kondrashov. For the complete reports, see the Reviewers' Reports section.
C1 [Rogozin, Igor B.; Koonin, Eugene V.] Natl Ctr Biotechnol Informat NLM NIH, Bethesda, MD 20894 USA.
[Carmel, Liran] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel.
[Csuros, Miklos] Univ Montreal, Dept Comp Sci & Operat Res, Montreal, PQ, Canada.
RP Koonin, EV (reprint author), Natl Ctr Biotechnol Informat NLM NIH, 8600 Rockville Pike,Bldg 38A, Bethesda, MD 20894 USA.
EM koonin@ncbi.nlm.nih.gov
FU National Library of Medicine at National Institutes of Health/DHHS (NIH)
[Z01LM000073-12]; National Sciences and Engineering Research Council of
Canada; European Union [PIRG05-GA-2009-248639]
FX We thank Ben Busby, Nicholas Dibb, Cedric Feschotte, Michael Lynch,
Masatoshi Nei, Scott Roy, Arlin Stoltzfus, and Yuri Wolf for useful
discussions. This work was supported in part by the Intramural Research
Program of the National Library of Medicine at National Institutes of
Health/DHHS (the NIH grant Z01LM000073-12), by a research grant from the
National Sciences and Engineering Research Council of Canada, and by the
European Union Marie Curie International Reintegration Grant
(PIRG05-GA-2009-248639).
NR 287
TC 81
Z9 82
U1 10
U2 116
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6150
J9 BIOL DIRECT
JI Biol. Direct
PD APR 16
PY 2012
VL 7
AR 11
DI 10.1186/1745-6150-7-11
PG 28
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 031EP
UT WOS:000310622100001
PM 22507701
ER
PT J
AU Driscoll, I
Martin, B
An, Y
Maudsley, S
Ferrucci, L
Mattson, MP
Resnick, SM
AF Driscoll, Ira
Martin, Bronwen
An, Yang
Maudsley, Stuart
Ferrucci, Luigi
Mattson, Mark P.
Resnick, Susan M.
TI Plasma BDNF Is Associated with Age-Related White Matter Atrophy but Not
with Cognitive Function in Older, Non-Demented Adults
SO PLOS ONE
LA English
DT Article
ID FACTOR VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR; HIPPOCAMPAL VOLUME;
ENERGY RESTRICTION; IMPAIRMENT; HEALTHY; DISEASE; WEIGHT; IMPACT; WOMEN
AB Brain derived neurotrophic factor (BDNF) seems to be involved in regulation of synaptic plasticity and neurogenesis. BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examined whether BDNF plasma concentration was associated with rates of age-related change in cognitive performance (n = 429) and regional brain volume (n = 59). Plasma BDNF levels, which were significantly higher in females (p<0.05), were not associated with either concurrent cognitive performance or rates of age-related change in performance across cognitive domains (p's>0.05). Sex differences in the relationship between BDNF and the trajectories of regional brain volume changes were observed for the whole brain and frontal white matter volumes (p<0.05), whereby lower plasma BDNF was associated with steeper volume decline in females but not males. Together, our findings contribute to furthering the understanding of the relationships between plasma BDNF, structural brain integrity and cognition. Potential mechanisms mediating these relationships merit further investigation.
C1 [Driscoll, Ira; An, Yang; Resnick, Susan M.] NIA, Lab Behav Neurosci, Baltimore, MD 21224 USA.
[Driscoll, Ira] Univ Wisconsin Milwaukee, Dept Psychol, Milwaukee, WI USA.
[Martin, Bronwen] NIA, Clin Invest Lab, Baltimore, MD 21224 USA.
[Maudsley, Stuart; Mattson, Mark P.] NIA, Neurosci Lab, Baltimore, MD 21224 USA.
[Ferrucci, Luigi] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
RP Driscoll, I (reprint author), NIA, Lab Behav Neurosci, Baltimore, MD 21224 USA.
EM driscoli@uwm.edu
FU Intramural Research Program of the National Institute on Aging
FX This research was supported by the Intramural Research Program of the
National Institute on Aging. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 52
TC 30
Z9 30
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 16
PY 2012
VL 7
IS 4
AR e35217
DI 10.1371/journal.pone.0035217
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959VO
UT WOS:000305345000049
PM 22523577
ER
PT J
AU Anwar, K
Klemm, RW
Condon, A
Severin, KN
Zhang, M
Ghirlando, R
Hu, JJ
Rapoport, TA
Prinz, WA
AF Anwar, Kamran
Klemm, Robin W.
Condon, Amanda
Severin, Katharina N.
Zhang, Miao
Ghirlando, Rodolfo
Hu, Junjie
Rapoport, Tom A.
Prinz, William A.
TI The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S.
cerevisiae
SO JOURNAL OF CELL BIOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM MEMBRANES; SEDIMENTATION-VELOCITY; NUCLEAR-FUSION;
ANALYTICAL ULTRACENTRIFUGATION; SACCHAROMYCES-CEREVISIAE;
GOLGI-APPARATUS; YEAST; ARABIDOPSIS; ATLASTIN; REVEALS
AB The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) called atlastins (ATLs), which are also required to maintain ER morphology. Previous work suggested that the dynamin-like GTPase Sey1p was needed to maintain ER morphology in Saccharomyces cerevisiae. In this paper, we demonstrate that Sey1p, like ATLs, mediates homotypic ER fusion. The absence of Sey1p resulted in the ER undergoing delayed fusion in vivo and proteoliposomes containing purified Sey1p fused in a GTP-dependent manner in vitro. Sey1p could be partially replaced by ATL1 in vivo. Like ATL1, Sey1p underwent GTP-dependent dimerization. We found that the residual ER-ER fusion that occurred in cells lacking Sey1p required the ER SNARE Ufe1p. Collectively, our results show that Sey1p and its homologues function analogously to ATLs in mediating ER fusion. They also indicate that S. cerevisiae has an alternative fusion mechanism that requires ER SNAREs.
C1 [Anwar, Kamran; Condon, Amanda; Prinz, William A.] NIDDK, Lab Mol & Cell Biol, NIH, Bethesda, MD 20892 USA.
[Ghirlando, Rodolfo] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
[Klemm, Robin W.; Severin, Katharina N.; Rapoport, Tom A.] Harvard Univ, Sch Med, Dept Cell Biol, Howard Hughes Med Inst, Boston, MA 02115 USA.
[Zhang, Miao; Hu, Junjie] Nankai Univ, Coll Life Sci, Dept Genet & Cell Biol, Tianjin 300071, Peoples R China.
[Zhang, Miao; Hu, Junjie] Nankai Univ, Coll Life Sci, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China.
RP Prinz, WA (reprint author), NIDDK, Lab Mol & Cell Biol, NIH, Bethesda, MD 20892 USA.
EM wprinz@helix.nih.gov
RI Hu, Junjie/F-9713-2013; Klemm, Robin/C-5463-2014
OI Klemm, Robin/0000-0003-2313-8240
FU National Basic Research Program of China (973 Program) [2010CB833702];
National Institute of Diabetes and Digestive and Kidney Diseases
FX J. Hu is supported by the National Basic Research Program of China (973
Program; grant 2010CB833702). W.A. Prinz, K. Anwar, and A. Condon are
supported by the Intramural Research Program of the National Institute
of Diabetes and Digestive and Kidney Diseases. T.A. Rapoport is a Howard
Hughes Medical Institute Investigator.
NR 27
TC 42
Z9 42
U1 0
U2 1
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA
SN 0021-9525
J9 J CELL BIOL
JI J. Cell Biol.
PD APR 16
PY 2012
VL 197
IS 2
BP 209
EP 217
DI 10.1083/jcb.201111115
PG 9
WC Cell Biology
SC Cell Biology
GA 927MU
UT WOS:000302912600007
PM 22508509
ER
PT J
AU Kapetanovic, IM
Lyubimov, AV
Kabirova, EV
Kabirov, KK
Rasay, L
Swezey, R
Green, C
Kopelovich, L
AF Kapetanovic, Izet M.
Lyubimov, Alexander V.
Kabirova, Elena V.
Kabirov, Kasim K.
Rasay, Laura
Swezey, Robert
Green, Carol
Kopelovich, Levy
TI Effects of bacterial and presystemic nitroreductase metabolism of
2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and
bioavailability
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Nitroreductases; Ames assay; Nitro compounds; Rat; Dog; Chemoprevention
ID DRUGS
AB 2-Chloro-5-nitro-N-phenylbenzamide (GW9662), a potent irreversible PPAR-gamma antagonist, has shown promise as a cancer chemopreventive agent and is undergoing preclinical evaluations. Studies were initiated to assess its bacterial mutagenicity and pharmacokinetic profile in two animal species prior to subchronic oral toxicity evaluations and the results are reported here. GW9662 was mutagenic in both TA98 and TA100 bacterial strains with and without metabolic activation but was negative in the nitroreductase-deficient strains (TA98NR and TA100NR) also with and without metabolic activation, indicating that GW9662 mutagenicity is dependent on nitroreduction. The mutagenic activity was predominantly via a base-substitution mechanism. Following oral dosing in rats and dogs, the parent compound, GW9662, was virtually absent from plasma samples, but there was chromatographic evidence for the presence of metabolites in the plasma as a result of oral dosing. Metabolite identification studies showed that an amine metabolite ACPB (5-amino-2-chloro-N-phenylbenzamide), a product of nitro reduction, was the predominant species exhibiting large and persistent plasma levels. Thus systemic circulation of GW9662 has been attained largely in the form of its reduced metabolite, probably a product of gut bacterial metabolism. GW9662 was detectable in plasma of rats and dogs after intravenous dose albeit at low concentrations. Pharmacokinetic analysis following intravenous dosing in rats showed a rapid clearance and an extensive tissue distribution which could have accounted for the very low plasma levels. Of note, the amine metabolite was absent following intravenous dosing in both rats and dogs, confirming it being a product of presystemic metabolism. The potential utility of GW9662 as a chemopreventive agent, especially as an Estrogen Receptor-alpha (ER-alpha) inducer in an otherwise ER-a negative breast tissue, is of great interest. However, the results shown here suggest that additional animal toxicological and bioavailability studies are required to establish a role of GW9662 as a chemopreventive agent. Published by Elsevier Ireland Ltd.
C1 [Kapetanovic, Izet M.] NCI, Chemoprevent Agent Dev Res Grp, Canc Prevent Div, Bethesda, MD 20892 USA.
[Lyubimov, Alexander V.; Kabirova, Elena V.; Kabirov, Kasim K.] Univ Illinois, Toxicol Res Lab, Chicago, IL 60612 USA.
[Rasay, Laura; Swezey, Robert; Green, Carol] SRI Int, Biosci Div, Menlo Pk, CA 94025 USA.
RP Kapetanovic, IM (reprint author), NCI, Chemoprevent Agent Dev Res Grp, Canc Prevent Div, 6130 Execut Blvd,Rm 2116, Bethesda, MD 20892 USA.
EM kapetani@mail.nih.gov
FU National Cancer Institute, Department of Health and Human Services
[N01-CN-43305, N01-CN-43306]
FX These studies were supported by contract numbers N01-CN-43305 and
N01-CN-43306 from the National Cancer Institute, Department of Health
and Human Services.
NR 5
TC 1
Z9 1
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD APR 15
PY 2012
VL 197
IS 1
BP 16
EP 22
DI 10.1016/j.cbi.2012.03.002
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 941OP
UT WOS:000303972800003
PM 22450444
ER
PT J
AU Canepa, M
Strait, JB
Abramov, D
Milaneschi, Y
AlCihatrif, M
Moni, M
Ramachandran, R
Najjar, SS
Brunelli, C
Abraham, TP
Lakatta, EG
Ferrucci, L
AF Canepa, Marco
Strait, James B.
Abramov, Dmitry
Milaneschi, Yuri
AlCihatrif, Majd
Moni, Monika
Ramachandran, Ramona
Najjar, Samer S.
Brunelli, Claudio
Abraham, Theodore P.
Lakatta, Edward G.
Ferrucci, Luigi
TI Contribution of Central Adiposity to Left Ventricular Diastolic Function
(from the Baltimore Longitudinal Study of Aging)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID OF-THE-LITERATURE; BODY-MASS INDEX; TO-HIP RATIO; HEART-FAILURE; WAIST
CIRCUMFERENCE; CARDIOVASCULAR-DISEASE; EJECTION FRACTION; CENTRAL
OBESITY; RISK; DYSFUNCTION
AB We examined the relations of central adiposity with left ventricular (LV) diastolic dysfunction in men and women who participated in the Baltimore Longitudinal Study of Aging, a prospective community-based study of older persons. The sample for this cross-sectional analysis included 399 women and 370 men. Central adiposity was estimated using the waist circumference (WC) and global adiposity using the body mass index (BMI). Using data from a comprehensive echocardiographic study that included tissue Doppler imaging, diastolic function was graded according to 3 parameters (E/A ratio, E/Em ratio, and left atrial volume index). In the logistic regression models adjusted for age, gender, cardiovascular risk factors, and hemodynamic parameters, WC and BMI were both independently associated with LV diastolic dysfunction. However, when both WC and BMI were in the same model, only WC remained significantly associated with LV diastolic dysfunction (odds ratio 1.04, 95% confidence interval 1.01 to 1.08, p = 0.02). In the gender-stratified analyses, WC was significantly associated with LV diastolic dysfunction independently of BMI-in women (odds ratio 1.08, 95% confidence interval 1.04 to 1.14, p < 0.001) but not in men (odds ratio 1.00, 95% confidence interval 0.95 to 1.05, p = 0.91). Additional adjustment for LV mass index failed to modify these relations. In conclusion, the adverse effect of central adiposity on LV diastolic function was independent of general adiposity and more pronounced among women. The effect of visceral adiposity on LV diastolic dysfunction would benefit from confirmation in longitudinal studies. Published by Elsevier Inc. (Am J Cardiol 2012;109:1171-1178)
C1 [Canepa, Marco; Strait, James B.; Milaneschi, Yuri; Ramachandran, Ramona; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA.
[Canepa, Marco; Strait, James B.; Abramov, Dmitry; AlCihatrif, Majd; Moni, Monika; Najjar, Samer S.; Lakatta, Edward G.] NIA, Cardiovasc Sci Lab, Human Cardiovasc Studies Unit, NIH, Baltimore, MD 21224 USA.
[Najjar, Samer S.] Washington Hosp Ctr, Res Inst, Washington, DC 20010 USA.
[Canepa, Marco; Brunelli, Claudio] Univ Genoa, Div Cardiol, Res Ctr Cardiovasc Biol, Genoa, Italy.
[Abraham, Theodore P.] Johns Hopkins Univ, Div Cardiovasc Dis, Baltimore, MD USA.
RP Canepa, M (reprint author), NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA.
EM marco.canepa@nih.gov
FU National Institutes of Health, National Institute on Aging (Bethesda,
Maryland)
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute on Aging (Bethesda,
Maryland).
NR 30
TC 22
Z9 23
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 15
PY 2012
VL 109
IS 8
BP 1171
EP 1178
DI 10.1016/j.amjcard.2011.11.054
PG 8
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 931NP
UT WOS:000303226900015
PM 22257709
ER
PT J
AU Hutter, CM
Chang-Claude, J
Slattery, ML
Pflugeisen, BM
Lin, Y
Duggan, D
Nan, HM
Lemire, M
Rangrej, J
Figueiredo, JC
Jiao, S
Harrison, TA
Liu, Y
Chen, LS
Stelling, DL
Warnick, GS
Hoffmeister, M
Kury, S
Fuchs, CS
Giovannucci, E
Hazra, A
Kraft, P
Hunter, DJ
Gallinger, S
Zanke, BW
Brenner, H
Frank, B
Ma, J
Ulrich, CM
White, E
Newcomb, PA
Kooperberg, C
LaCroix, AZ
Prentice, RL
Jackson, RD
Schoen, RE
Chanock, SJ
Berndt, SI
Hayes, RB
Caan, BJ
Potter, JD
Hsu, L
Bezieau, S
Chan, AT
Hudson, TJ
Peters, U
AF Hutter, Carolyn M.
Chang-Claude, Jenny
Slattery, Martha L.
Pflugeisen, Bethann M.
Lin, Yi
Duggan, David
Nan, Hongmei
Lemire, Mathieu
Rangrej, Jagadish
Figueiredo, Jane C.
Jiao, Shuo
Harrison, Tabitha A.
Liu, Yan
Chen, Lin S.
Stelling, Deanna L.
Warnick, Greg S.
Hoffmeister, Michael
Kuery, Sebastien
Fuchs, Charles S.
Giovannucci, Edward
Hazra, Aditi
Kraft, Peter
Hunter, David J.
Gallinger, Steven
Zanke, Brent W.
Brenner, Hermann
Frank, Bernd
Ma, Jing
Ulrich, Cornelia M.
White, Emily
Newcomb, Polly A.
Kooperberg, Charles
LaCroix, Andrea Z.
Prentice, Ross L.
Jackson, Rebecca D.
Schoen, Robert E.
Chanock, Stephen J.
Berndt, Sonja I.
Hayes, Richard B.
Caan, Bette J.
Potter, John D.
Hsu, Li
Bezieau, Stephane
Chan, Andrew T.
Hudson, Thomas J.
Peters, Ulrike
TI Characterization of Gene-Environment Interactions for Colorectal Cancer
Susceptibility Loci
SO CANCER RESEARCH
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; COLON-CANCER; CHROMOSOME 8Q24; LIFE-STYLE; RISK
LOCI; METAANALYSIS; HEALTH; VARIANTS; FRUIT; SCAN
AB Genome-wide association studies (GWAS) have identified more than a dozen loci associated with colorectal cancer (CRC) risk. Here, we examined potential effect-modification between single-nucleotide polymorphisms (SNP) at 10 of these loci and probable or established environmental risk factors for CRC in 7,016 CRC cases and 9,723 controls from nine cohort and case-control studies. We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber). The strongest statistical evidence for a gene-environment interaction across studies was for vegetable consumption and rs16892766, located on chromosome 8q23.3, near the EIF3H and UTP23 genes (nominal P-interaction = 1.3 x 10(-4); adjusted P = 0.02). The magnitude of the main effect of the SNP increased with increasing levels of vegetable consumption. No other interactions were statistically significant after adjusting for multiple comparisons. Overall, the association of most CRC susceptibility loci identified in initial GWAS seems to be invariant to the other risk factors considered; however, our results suggest potential modification of the rs16892766 effect by vegetable consumption. Cancer Res; 72(8); 2036-44. (C) 2012 AACR.
C1 [Hutter, Carolyn M.; Pflugeisen, Bethann M.; Lin, Yi; Jiao, Shuo; Harrison, Tabitha A.; Stelling, Deanna L.; Warnick, Greg S.; Ulrich, Cornelia M.; White, Emily; Newcomb, Polly A.; Kooperberg, Charles; LaCroix, Andrea Z.; Prentice, Ross L.; Potter, John D.; Hsu, Li; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Hutter, Carolyn M.; Ulrich, Cornelia M.; White, Emily; Newcomb, Polly A.; Potter, John D.; Peters, Ulrike] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
[Kooperberg, Charles; Hsu, Li] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Chang-Claude, Jenny] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany.
[Hoffmeister, Michael; Brenner, Hermann; Frank, Bernd] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-6900 Heidelberg, Germany.
[Ulrich, Cornelia M.] German Canc Res Ctr, Div Prevent Oncol, D-6900 Heidelberg, Germany.
[Slattery, Martha L.] Univ Utah, Dept Internal Med, Hlth Sci Ctr, Salt Lake City, UT 84112 USA.
[Duggan, David] Translat Genom Res Inst, Phoenix, AZ USA.
[Nan, Hongmei; Fuchs, Charles S.; Giovannucci, Edward; Hazra, Aditi; Ma, Jing; Chan, Andrew T.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
[Nan, Hongmei; Fuchs, Charles S.; Giovannucci, Edward; Hazra, Aditi; Ma, Jing; Chan, Andrew T.] Harvard Univ, Sch Med, Boston, MA USA.
[Nan, Hongmei; Hazra, Aditi; Kraft, Peter; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA.
[Giovannucci, Edward] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Fuchs, Charles S.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.
[Chan, Andrew T.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
[Lemire, Mathieu; Rangrej, Jagadish; Hudson, Thomas J.] Ontario Inst Canc Res, Toronto, ON, Canada.
[Gallinger, Steven] Toronto Gen Hosp, Univ Hlth Network, Dept Surg, Toronto, ON, Canada.
[Hudson, Thomas J.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
[Hudson, Thomas J.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
[Figueiredo, Jane C.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Liu, Yan] Stephens & Associates, Carrollton, TX USA.
[Chen, Lin S.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
[Kuery, Sebastien; Bezieau, Stephane] CHU Nantes, Serv Genet Med, F-44035 Nantes 01, France.
[Zanke, Brent W.] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
[Jackson, Rebecca D.] Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
[Schoen, Robert E.] Univ Pittsburgh, Dept Epidemiol, Med Ctr, Pittsburgh, PA 15261 USA.
[Chanock, Stephen J.; Berndt, Sonja I.] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Hayes, Richard B.] NYU, Sch Med, Dept Environm Med, Div Epidemiol, New York, NY USA.
[Caan, Bette J.] Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA.
[Potter, John D.] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand.
RP Hutter, CM (reprint author), 1100 Fairview Ave N,M4-B402,POB 19024, Seattle, WA 98109 USA.
EM chutter@fhcrc.org
RI Gallinger, Steven/E-4575-2013; Hoffmeister, Michael/B-5745-2012; KURY,
Sebastien/G-5971-2015; Bezieau, stephane/G-5621-2015; Brenner,
Hermann/B-4627-2017;
OI Hayes, Richard/0000-0002-0918-661X; Hoffmeister,
Michael/0000-0002-8307-3197; KURY, Sebastien/0000-0001-5497-0465;
Bezieau, stephane/0000-0003-0095-1319; Brenner,
Hermann/0000-0002-6129-1572; Potter, John/0000-0001-5439-1500
FU Ontario Research Fund; Canadian Institutes of Health Research; Canadian
Cancer Society Research Institute; Ontario Institute for Cancer Research
through Ontario Ministry of Research; regional Hospital Clinical
Research Program (PHRC); Regional Council of Pays de la Loire;
Groupement des Entreprises Francaises dans la Lutte contre le Cancer
(GEFLUC); Association Anne de Bretagne Genetique; Ligue Regionale Contre
le Cancer (LRCC); National Cancer Institute, NIH [CA-95-011]; German
Research Council (Deutsche Forschungsgemeinschaft) [BR 1704/6-1, BR
1704/6-3, BR 1704/6-4, CH 117/1-1]; German Federal Ministry of Education
and Research [01KH0404, 01ER0814]; National Cancer Institute, NIH, U.S.
Department of Health and Human Services [R01 CA48998]; National Cancer
Institute; National Institutes of Health; U.S. Department of Health and
Human Services [R01 CA059045, R25 CA094880, U01 CA137088]; Institutes of
Health; NIH [P01 CA 055075, P50 CA 127003, R01 137178, P01 CA 087969];
Division of Cancer Epidemiology and Genetics; Division of Cancer
Prevention; NIH, Genes, Environment and Health Initiative [NIH GEI] [Z01
CP 010200, U01 HG 004438]; Gene Environment Association Studies, GENEVA
Coordinating Center [U01 HG004446]; Johns Hopkins University Center for
Inherited Disease Research; National Heart, Lung, and Blood Institute,
NIH; U. S. Department of Health and Human Services
[HHSN268201100001C-4C, HHSN268201100046C, HHSN271201100004C, NO1WH4421];
[U01 CA074783]
FX ARTIC was supported by a GL2 grant from the Ontario Research Fund, the
Canadian Institutes of Health Research, and the Cancer Risk Evaluation
(CaRE) Program grant from the Canadian Cancer Society Research
Institute. T.J. Hudson and B. W. Zanke are recipients of Senior
Investigator Awards from the Ontario Institute for Cancer Research,
through generous support from the Ontario Ministry of Research.;
ASTERISK was supported by a regional Hospital Clinical Research Program
(PHRC) and supported by the Regional Council of Pays de la Loire, the
Groupement des Entreprises Francaises dans la Lutte contre le Cancer
(GEFLUC), the Association Anne de Bretagne Genetique, and the Ligue
Regionale Contre le Cancer (LRCC).; CCFR was supported by the National
Cancer Institute, NIH under RFA # CA-95-011 and through cooperative
agreements with members of the Colon Cancer Family Registry and P.I.s.
The Colon CFR Center, Ontario Registry for Studies of Familial CRC,
contributed data to this manuscript and was supported by (U01
CA074783).; DACHS was supported by grants from the German Research
Council (Deutsche Forschungsgemeinschaft, BR 1704/6-1, BR 1704/6-3, BR
1704/6-4, and CH 117/1-1), and the German Federal Ministry of Education
and Research (01KH0404 and 01ER0814).; DALS was supported by the
National Cancer Institute, NIH, U.S. Department of Health and Human
Services (R01 CA48998 to M.L. Slattery).; Funding for the genome-wide
scan of DALS, PLCO, and WHI was provided by the National Cancer
Institute, National Institutes of Health, U.S. Department of Health and
Human Services (R01 CA059045 to U. Peters). C.M. Hutter was supported by
a training grant from the National Cancer Institute, Institutes of
Health, U.S. Department of Health and Human Services (R25 CA094880).
Additional funding for this work was provided by National Cancer
Institute, National Institutes of Health, U.S. Department of Health and
Human Services (U01 CA137088 to U. Peters).; HPFS was supported by the
NIH (P01 CA 055075 to C. S. Fuchs, R01 137178 to A. T. Chan, and P50 CA
127003 to C. S. Fuchs), NHS by the NIH (R01 137178 to A.T. Chan., P50 CA
127003 to C. S. Fuchs., and P01 CA 087969 to E. L. Giovannucci) and PHS
by the NIH (CA41281).; PLCO was supported in part by the Intramural
Research Program of the Division of Cancer Epidemiology and Genetics,
the Division of Cancer Prevention, National Cancer Institute, NIH, U.S.
Department of Health and Human Services.; Control samples were genotyped
as part of the Cancer Genetic Markers of Susceptibility (CGEMS) prostate
cancer scan and were supported by the Intramural Research Program of the
National Cancer Institute. The data sets used in this analysis were
accessed with appropriate approval through the dbGaP online resource
(54) through dbGaP accession number 000207v.1p1.c1 (20). Control samples
were also genotyped as part of the GWAS of Lung Cancer and Smoking. This
work was supported by NIH, Genes, Environment and Health Initiative [NIH
GEI] (Z01 CP 010200). The human subjects participating in the GWAS are
derived from the Prostate, Lung, Colon and Ovarian Screening Trial and
the study is supported by intramural resources of the National Cancer
Institute. Assistance with genotype cleaning, as well as with general
study coordination, was provided by the Gene Environment Association
Studies, GENEVA Coordinating Center (U01 HG004446). Assistance with data
cleaning was provided by the National Center for Biotechnology
Information. Funding support for genotyping, which was carried out at
the Johns Hopkins University Center for Inherited Disease Research, was
provided by the NIH GEI (U01 HG 004438). The data sets used for the
analyses described in this article were obtained from dbGaP through
National Center for Biotechnology Information (55), through dbGaP
accession number ph000093.v2.p2.c1. The WHI program was supported by the
National Heart, Lung, and Blood Institute, NIH, U. S. Department of
Health and Human Services through contracts HHSN268201100001C-4C,
HHSN268201100046C and HHSN271201100004C, and NO1WH4421.
NR 55
TC 64
Z9 67
U1 0
U2 22
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
IS 8
BP 2036
EP 2044
DI 10.1158/0008-5472.CAN-11-4067
PG 9
WC Oncology
SC Oncology
GA 927KH
UT WOS:000302905700015
PM 22367214
ER
PT J
AU Chernikova, SB
Razorenova, OV
Higgins, JP
Sishc, BJ
Nicolau, M
Dorth, JA
Chernikova, DA
Kwok, S
Brooks, JD
Bailey, SM
Game, JC
Brown, JM
AF Chernikova, Sophia B.
Razorenova, Olga V.
Higgins, John P.
Sishc, Brock J.
Nicolau, Monica
Dorth, Jennifer A.
Chernikova, Diana A.
Kwok, Shirley
Brooks, James D.
Bailey, Susan M.
Game, John C.
Brown, J. Martin
TI Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40)
Leads to Replication Stress and Chromosomal Instability
SO CANCER RESEARCH
LA English
DT Article
ID DOUBLE-STRAND BREAKS; GERM-CELL TUMORS; GENE-EXPRESSION; HOMOLOGOUS
RECOMBINATION; TESTICULAR CANCER; H3K4 METHYLATION; GENOME STABILITY;
S-PHASE; REPAIR; UBIQUITYLATION
AB Mammalian Bre1 complexes (BRE1A/B (RNF20/40) in humans and Bre1a/b (Rnf20/40) in mice) function similarly to their yeast homolog Bre1 as ubiquitin ligases in monoubiquitination of histone H2B. This ubiquitination facilitates methylation of histone H3 at K4 and K79, and accounts for the roles of Bre1 and its homologs in transcriptional regulation. Recent studies by others suggested that Bre1 acts as a tumor suppressor, augmenting expression of select tumor suppressor genes and suppressing select oncogenes. In this study, we present an additional mechanism of tumor suppression by Bre1 through maintenance of genomic stability. We track the evolution of genomic instability in Bre1-deficient cells from replication-associated double-strand breaks (DSB) to specific genomic rearrangements that explain a rapid increase in DNA content and trigger breakage-fusion-bridge cycles. We show that aberrant RNA-DNA structures (R-loops) constitute a significant source of DSBs in Bre1-deficient cells. Combined with a previously reported defect in homologous recombination, generation of R-loops is a likely initiator of replication stress and genomic instability in Bre1-deficient cells. We propose that genomic instability triggered by Bre1 deficiency may be an important early step that precedes acquisition of an invasive phenotype, as we find decreased levels of BRE1A/B and dimethylated H3K79 in testicular seminoma and in the premalignant lesion in situ carcinoma. Cancer Res; 72(8); 2111-9. (C) 2012 AACR.
C1 [Chernikova, Sophia B.; Razorenova, Olga V.; Dorth, Jennifer A.; Game, John C.; Brown, J. Martin] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA.
[Higgins, John P.; Kwok, Shirley] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA.
[Nicolau, Monica] Stanford Univ, Dept Math, Stanford, CA 94305 USA.
[Brooks, James D.] Stanford Univ, Dept Urol, Stanford, CA 94305 USA.
[Sishc, Brock J.; Bailey, Susan M.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
[Chernikova, Diana A.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Brown, JM (reprint author), Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA.
EM mbrown@stanford.edu
FU National Cancer Institute [CA67166]
FX The work was supported by grant CA67166 awarded to JMB by the National
Cancer Institute.
NR 50
TC 36
Z9 36
U1 0
U2 6
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
IS 8
BP 2111
EP 2119
DI 10.1158/0008-5472.CAN-11-2209
PG 9
WC Oncology
SC Oncology
GA 927KH
UT WOS:000302905700022
PM 22354749
ER
PT J
AU Wilsker, D
Chung, JH
Bunz, F
AF Wilsker, Deborah
Chung, Jon H.
Bunz, Fred
TI Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient
cancer cells
SO CELL CYCLE
LA English
DT Article
DE p53; Chk1; tetraploid; mitosis
ID DNA-DAMAGE CHECKPOINT; PROTEIN PHOSPHATASE 2A; HUMAN SOMATIC-CELLS;
CHROMOSOMAL INSTABILITY; MAMMALIAN-CELLS; GENOMIC INSTABILITY; GENETIC
INSTABILITY; KINASE 1; ATR; PHOSPHORYLATION
AB Many cancer cells are unable to maintain a numerically stable chromosome complement. It is well established that aberrant cell division can generate progeny with increased ploidy, but the genetic factors required for maintenance of diploidy are not well understood. Using an isogenic model system derived by gene targeting, we examined the role of Chk1 in p53-proficient and -deficient cancer cells. Targeted inactivation of a single CHK1 allele in stably diploid cells caused an elevated frequency of mitotic bypass if p53 was naturally mutated or experimentally disrupted by homologous recombination. CHK1-haploinsufficient, p53-deficient cells frequently underwent sequential rounds of DNA synthesis without an intervening mitosis. These aberrant cell cycles resulted in whole-genome endoreduplication and tetraploidization. The unscheduled bypass of mitosis could be suppressed by targeted reversion of a p53 mutation or by exogenous expression of Cdk1. In contrast, the number of tetraploid cells was not increased in isogenic cell populations that harbor hypomorphic ATR mutations, suggesting that suppression of unscheduled mitotic bypass is a distinct function of Chk1. These results are consistent with a recently described role for Chk1 in promoting the expression of genes that promote cell cycle transitions and demonstrate how Chk1 might prevent tetraploidization during the cancer cell cycle.
C1 [Chung, Jon H.; Bunz, Fred] Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21218 USA.
[Wilsker, Deborah] NCI, Mol Radiat Therapeut Branch, SAIC Frederick, Frederick, MD 21701 USA.
RP Bunz, F (reprint author), Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21218 USA.
EM fredbunz@jhmi.edu
OI Chung, Jon/0000-0003-0526-3670
FU Flight Attendant Medical Research Institute; National Cancer Institute
[R01CA157535, F32CA119724]
FX The authors gratefully acknowledge the expert assistance of the staff of
the Kimmel Cancer Center Cell Imaging Core facility and the Flow
Cytometry Core facility. We thank David Morgan for Cdk1 expression
plasmids. Support for this work was provided by the Flight Attendant
Medical Research Institute and the National Cancer Institute grants
R01CA157535 (F.B.) and F32CA119724 (D.W.).
NR 45
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Z9 7
U1 0
U2 9
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
J9 CELL CYCLE
JI Cell Cycle
PD APR 15
PY 2012
VL 11
IS 8
BP 1564
EP 1572
DI 10.4161/cc.19944
PG 9
WC Cell Biology
SC Cell Biology
GA 930TC
UT WOS:000303162100018
PM 22433954
ER
PT J
AU Futatsugi, A
Utreras, E
Rudrabhatla, P
Jaffe, H
Pant, HC
Kulkarni, AB
AF Futatsugi, Akira
Utreras, Elias
Rudrabhatla, Parvathi
Jaffe, Howard
Pant, Harish C.
Kulkarni, Ashok B.
TI Cyclin-dependent kinase 5 regulates E2F transcription factor through
phosphorylation of Rb protein in neurons
SO CELL CYCLE
LA English
DT Article
DE Cdk5; phosphorylation; cell cycle; retinoblastoma protein; E2F
transcription factor; cell death; neurons
ID CELL-CYCLE; RETINOBLASTOMA PROTEIN; ALZHEIMERS-DISEASE;
NUCLEAR-LOCALIZATION; ACTIVATOR P35; AMYLOID-BETA; DNA-DAMAGE; CDK5;
DEATH; NEURODEGENERATION
AB Recent studies have shown the involvement of cyclin-dependent kinase 5 (Cdk5) in cell cycle regulation in postmitotic neurons. In this study, we demonstrate that Cdk5 and its co-activator p35 were detected in the nuclear fraction in neurons and Cdk5/p35 phosphorylated retinoblastoma (Rb) protein, a key protein controlling cell cycle re-entry. Cdk5/p35 phosphorylates Rb at the sites similar to those phosphorylated by Cdk4 and Cdk2. Furthermore, increased Cdk5 activity elevates activity of E2F transcription factor, which can trigger cell cycle re-entry, leading to neuronal cell death. A normal Cdk5 activity in neurons did not induce E2F activation, suggesting that Cdk5 does not induce cell cycle re-entry under normal conditions. Taken together, these results indicate that Cdk5 can regulate cell cycle by its ability to phosphorylate Rb. Most importantly, increased Cdk5 activity induces cell cycle re-entry, which is especially detrimental for survival of postmitotic neurons.
C1 [Futatsugi, Akira; Utreras, Elias; Kulkarni, Ashok B.] Natl Inst Dent & Craniofacial Res, Funct Genom Sect, Lab Cell & Dev Biol, NIH, Bethesda, MD USA.
[Rudrabhatla, Parvathi; Pant, Harish C.] Natl Inst Neurol Disorders & Stroke, Neurochem Lab, NIH, Bethesda, MD USA.
[Jaffe, Howard] Natl Inst Neurol Disorders & Stroke, Prot & Peptide Facil, NIH, Bethesda, MD USA.
RP Kulkarni, AB (reprint author), Natl Inst Dent & Craniofacial Res, Funct Genom Sect, Lab Cell & Dev Biol, NIH, Bethesda, MD USA.
EM ak40m@nih.gov
RI utreras, elias/I-1038-2013
OI utreras, elias/0000-0002-1004-0466
FU Intramural Divisions of the National Institute of Dental and
Craniofacial Research; National Institute of Neurological Disorders and
Stroke, National Institutes of Health
FX We would like to thank Dr. Sushil Rane for critical reading of the
manuscript, Ms. Shelagh Powers for expert editorial assistance and Dr.
Yoko Futatsugi for help in manuscript preparation. These studies were
supported by the Intramural Divisions of the National Institute of
Dental and Craniofacial Research and the National Institute of
Neurological Disorders and Stroke, National Institutes of Health.
NR 50
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Z9 18
U1 1
U2 3
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
J9 CELL CYCLE
JI Cell Cycle
PD APR 15
PY 2012
VL 11
IS 8
BP 1603
EP 1610
DI 10.4161/cc.20009
PG 8
WC Cell Biology
SC Cell Biology
GA 930TC
UT WOS:000303162100022
PM 22456337
ER
PT J
AU Bock, CW
Larkin, JD
AF Bock, Charles W.
Larkin, Joseph D.
TI Heats of formation for the boronic acids R-B(OH)(2) and boroxines R3B3O3
(R = H, Li, HBe, H2B, H3C, H2N, HO, F, and Cl) calculated at the G2, G3,
and G4 levels of theory
SO COMPUTATIONAL AND THEORETICAL CHEMISTRY
LA English
DT Article
DE Boroxines; Boronic acids; Heats of formation; G2; G3; G4
ID CORRELATED MOLECULAR CALCULATIONS; ACTIVE THERMOCHEMICAL TABLES;
GAUSSIAN-BASIS SETS; WAVE-FUNCTIONS; ALTERNATIVE APPROACH;
ELECTRONIC-STRUCTURE; ENERGIES; ATOMS; BOND; HYDROCARBONS
AB Boronic acids (R-B(OH)(2)) and their boroxine (R3B3O3) dehydration products have emerged as important classes of compounds with a multitude of diverse applications. However, the available heats of formation for these compounds are not always as accurate as would be required for further use. In this study the heats of formation at 298.15 K of R-B(OH)(2) and R3B3O3 (R = H, Li, HBe, H2B, H3C, H2N, HO, F, and Cl) have been calculated at the G2, G3[G3B3], and 04 levels of theory and used to determine the enthalpy changes for the dehydration reactions: 3R-B(OH)(2) -> R3B3O3 + 3H(2)O; comparisons are made with other rigorous levels of theory, e.g. CBS-Q[CBS-QB3] and W1U, as well as with experimental values wherever possible. Enthalpy changes for the dehydration reactions have also been calculated using second-order Moller-Plesset perturbation theory (MP2) with the Dunning-Woon correlation-consistent aug-cc-pVTZ and aug-cc-pVTZ basis sets, and B3LYP density functional theory with the 6-311++G(2df,2pd) basis set. With the exception of H2N-B(OH)2, the dehydration reactions are consistently predicted to be endothermic. Our results provide a cautionary note for the use of the B3LYP functional in the calculation of structures and energies of boronic acids and boroxines. Where comparisons could be made, the G4 and W1U predictions for the heats of formation of these boron compounds differ significantly. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Bock, Charles W.] Philadelphia Univ, Dept Chem & Biochem, Sch Sci & Hlth, Philadelphia, PA 19144 USA.
[Larkin, Joseph D.] NHLBI, NIH, Bethesda, MD 20851 USA.
RP Bock, CW (reprint author), Philadelphia Univ, Dept Chem & Biochem, Sch Sci & Hlth, Sch House Lane & Henry Ave, Philadelphia, PA 19144 USA.
EM bock.charles@gmail.com
FU NIH, NHLBI
FX This research was supported in part (J.D.L.) by the Intramural Research
Program of the NIH, NHLBI. The PQS Cluster Facility at Philadelphia
University. The authors would like to acknowledge helpful discussions
with Dr. George D. Markham.
NR 83
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U1 1
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2210-271X
J9 COMPUT THEOR CHEM
JI Comput. Theor. Chem.
PD APR 15
PY 2012
VL 986
BP 35
EP 42
DI 10.1016/j.comptc.2012.02.007
PG 8
WC Chemistry, Physical
SC Chemistry
GA 929PY
UT WOS:000303079100006
PM 24653975
ER
PT J
AU Adjemian, J
Olivier, KN
Seitz, AE
Holland, SM
Prevots, DR
AF Adjemian, Jennifer
Olivier, Kenneth N.
Seitz, Amy E.
Holland, Steven M.
Prevots, D. Rebecca
TI Prevalence of Nontuberculous Mycobacterial Lung Disease in US Medicare
Beneficiaries
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE nontuberculous mycobacteria; pulmonary; epidemiology; prevalence; United
States
ID UNITED-STATES; AVIUM-COMPLEX; CANCER SURVIVAL; HIV-INFECTION;
EPIDEMIOLOGY; CARE; TUBERCULOSIS; DISPARITIES; AUSTRALIA; QUALITY
AB Rationale: Pulmonary nontuberculous mycobacteria (PNTM) are an important cause of morbidity among older adults in the United States, but national prevalence estimates are lacking.
Objectives: To describe the prevalence and trends of PNTM disease among adults aged 65 years or older throughout the United States.
Methods: A nationally representative 5% sample of Medicare Part B beneficiaries was analyzed from 1997 to 2007. Demographic and medical claims data were compiled and prevalence estimates for PNTM and selected comorbidities were calculated and trends over time evaluated. Logistic regression was used to identify demographic and geographic factors associated with PNTM.
Measurements and Main Results: From 1997 to 2007, the annual prevalence significantly increased from 20 to 47 cases/100,000 persons, or 8.2% per year. The period prevalence was 112 cases/100,000 persons, although prevalence was twofold higher among Asians/Pacific Islanders than among whites (228 vs. 116 cases/100,000 persons). Western states had the highest period prevalence at 149 cases/100,000 persons, with Hawaii having the highest prevalence at 396 cases/100,000 persons, followed by southeastern states, which had a period prevalence of 131 cases/100,000 persons. PNTM cases had more comorbid conditions than noncases and were 40% more likely to die than noncases. Women were 1.4 times more likely to be a PNTM case than men. Relative to whites, Asians/Pacific Islanders were twice as likely to be a case, whereas blacks were half as likely.
Conclusions: The prevalence of PNTM is increasing across all regions of the United States and among both men and women. Significant racial/ethnic and geographic differences suggest important gene-environment interactions.
C1 [Adjemian, Jennifer; Olivier, Kenneth N.; Seitz, Amy E.; Holland, Steven M.; Prevots, D. Rebecca] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Adjemian, J (reprint author), Qrts 15 B-1,8 West Dr,MSC 2665, Bethesda, MD 20892 USA.
EM jennifer.adjemian@nih.gov
FU Division of Intramural Research, National Institute of Allergy and
Infectious Diseases
FX Supported by the Division of Intramural Research, National Institute of
Allergy and Infectious Diseases.
NR 52
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Z9 110
U1 1
U2 5
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD APR 15
PY 2012
VL 185
IS 8
BP 881
EP 886
DI 10.1164/rccm.201111-2016OC
PG 6
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 925MW
UT WOS:000302766300017
PM 22312016
ER
PT J
AU Ramsey, BW
Banks-Schlegel, S
Accurso, FJ
Boucher, RC
Cutting, GR
Engelhardt, JF
Guggino, WB
Karp, CL
Knowles, MR
Kolls, JK
LiPuma, JJ
Lynch, S
McCray, PB
Rubenstein, RC
Singh, PK
Sorscher, E
Welsh, M
AF Ramsey, Bonnie W.
Banks-Schlegel, Susan
Accurso, Frank J.
Boucher, Richard C.
Cutting, Garry R.
Engelhardt, John F.
Guggino, William B.
Karp, Christopher L.
Knowles, Michael R.
Kolls, Jay K.
LiPuma, John J.
Lynch, Susan
McCray, Paul B., Jr.
Rubenstein, Ronald C.
Singh, Pradeep K.
Sorscher, Eric
Welsh, Michael
TI Future Directions in Early Cystic Fibrosis Lung Disease Research An
NHLBI Workshop Report
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE cystic fibrosis; airway disease; innate immunity; microbiology; genetics
ID PSEUDOMONAS-AERUGINOSA INFECTION; YOUNG-CHILDREN; CLINICAL-TRIALS;
INFANTS; INFLAMMATION; MODEL; END; BIOMARKERS; CLEARANCE; MUTATIONS
AB Since the 1989 discovery that mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), there has been substantial progress toward understanding the molecular basis for CF lung disease, leading to the discovery and development of new therapeutic approaches. However, the earliest impact of the loss of CFTR function on airway physiology and structure and its relationship to initial infection and inflammation are poorly understood. Universal newborn screening for CF in the United States represents an unprecedented opportunity for investigating CF clinical manifestations very early in life. Recently developed animal models with pulmonary phenotypic manifestations also provide a window into the early consequences of this genetic disorder. For these reasons, the National Heart, Lung, and Blood Institute (NHLBI) convened a working group of extramural experts, entitled "Future Research Directions in Early CF Lung Disease" on September 21-22, 2010, to identify future research directions of great promise in CF. The priority areas identified included (1) exploring pathogenic mechanisms of early CF lung disease; (2) leveraging newborn screening to elucidate the natural history of early lung disease; (3) developing a spectrum of biomarkers of early lung disease that reflects CF pathophysiology, clinical outcome, and response to treatment; (4) exploring the role of genetics/genomics (e.g., modifier genes, gene-environmental interactions, and epigenetics) in early CF pathogenesis; (5) defining early microbiological events in CF lung disease; and (6) elucidating the initial airway inflammatory, remodeling, and repair mechanisms in CF lung disease.
C1 [Ramsey, Bonnie W.] Seattle Childrens Res Inst, CFFT Therapeut Dev Network Coordinating Ctr, Seattle, WA 98121 USA.
[Ramsey, Bonnie W.; Singh, Pradeep K.] Univ Washington, Sch Med, Seattle, WA USA.
[Banks-Schlegel, Susan] NHLBI, NIH, Bethesda, MD 20892 USA.
[Accurso, Frank J.] Univ Colorado, Sch Med, Denver, CO USA.
[Boucher, Richard C.; Knowles, Michael R.] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
[Cutting, Garry R.; Guggino, William B.] Johns Hopkins Sch Med, Baltimore, MD USA.
[Engelhardt, John F.] Univ Iowa, Sch Med, Iowa City, IA 52242 USA.
[Karp, Christopher L.] Univ Cincinnati, Coll Med, Cincinnati, OH USA.
[Karp, Christopher L.] Cincinnati Childrens Hosp Res Fdn, Div Mol Immunol, Cincinnati, OH USA.
[Kolls, Jay K.] Louisiana State Univ, Sch Med New Orleans, New Orleans, LA USA.
[LiPuma, John J.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Lynch, Susan] Univ Calif San Francisco, Sch Med, San Francisco, CA USA.
[McCray, Paul B., Jr.] Univ Iowa, Childrens Hosp, Iowa City, IA USA.
[Rubenstein, Ronald C.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Rubenstein, Ronald C.] Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Sorscher, Eric] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA.
[Welsh, Michael] Univ Iowa, Howard Hughes Med Inst, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
RP Ramsey, BW (reprint author), Seattle Childrens Res Inst, CFFT Therapeut Dev Network Coordinating Ctr, 2001 8th Ave,Mailstop CW8-5B, Seattle, WA 98121 USA.
EM bonnie.ramsey@seattlechildrens.org
OI Rubenstein, Ronald/0000-0002-3138-4006
FU Division of Lung Diseases, National Institutes of Health, of the U.S.
Department of Health and Human Services
FX Supported by the Division of Lung Diseases, National Institutes of
Health, of the U.S. Department of Health and Human Services.
NR 51
TC 29
Z9 29
U1 0
U2 9
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD APR 15
PY 2012
VL 185
IS 8
BP 887
EP 892
DI 10.1164/rccm.201111-2068WS
PG 6
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 925MW
UT WOS:000302766300018
PM 22312017
ER
PT J
AU Shaw, P
AF Shaw, Philip
TI Mapping Anomalies in Cortico-Striatal Trajectories in ADHD Using
Structural MRI
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Shaw, Philip] NHGRI, Social & Behav Res Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 23
BP 7S
EP 8S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000024
ER
PT J
AU Baumann, MH
AF Baumann, Michael H.
TI Neuropharmacology of Mephedrone and Methylone in the Rat
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE methcathinone; designer drugs; monoamines; transporters microdialysis
C1 [Baumann, Michael H.] NIDA, IRP, NIH, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 34
BP 11S
EP 11S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000035
ER
PT J
AU Knowles, EEM
Wesier, M
David, AS
Dickinson, D
Gold, J
Glahn, D
Davidson, M
Reichenberg, A
AF Knowles, Emma E. M.
Wesier, Mark
David, Anthony S.
Dickinson, Dwight
Gold, James
Glahn, David
Davidson, Michael
Reichenberg, Abraham
TI The Puzzle of Processing Speed, Memory and Executive Functioning
Impairments in Schizophrenia: Fitting the Pieces Together
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; Cognition; Executive Functioning; Processing Speed;
Modelling
C1 [Knowles, Emma E. M.; Glahn, David] Yale Univ, Dept Med, New Haven, CT 06520 USA.
[Knowles, Emma E. M.; David, Anthony S.; Reichenberg, Abraham] Inst Psychiat, Dept Psychosis Studies, London, England.
[Wesier, Mark; Davidson, Michael] Sheba Med Ctr, Div Psychiat, Ramat Gan, Israel.
[Dickinson, Dwight] NIMH, Intramural Res Program, NIH, Clin Brain Disorders Branch,Genes Cognit & Psycho, Bethesda, MD 20892 USA.
[Gold, James] Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA.
RI David, Anthony/C-1315-2011
OI David, Anthony/0000-0003-0967-774X
NR 0
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 92
BP 27S
EP 27S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000087
ER
PT J
AU Pickens, CL
Cifani, C
Navarre, BM
Eichenbaum, H
Theberge, FR
Baumann, MH
Calu, DJ
Shaham, Y
AF Pickens, Charles L.
Cifani, Carlo
Navarre, Brittany M.
Eichenbaum, Hila
Theberge, Florence R.
Baumann, Michael H.
Calu, Donna J.
Shaham, Yavin
TI Effect of Fenfluramine on Reinstatement of Food Seeking in Female and
Male Rats: Implications for the Predictive Validity of the Reinstatement
Model
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Relapse; Fenfluramine; Diet; Predictive validity; Reinstatement
C1 [Pickens, Charles L.; Cifani, Carlo; Navarre, Brittany M.; Eichenbaum, Hila; Theberge, Florence R.; Calu, Donna J.; Shaham, Yavin] NIDA, Behav Neurosci Branch, Baltimore, MD USA.
[Baumann, Michael H.] NIDA, Chem Biol Branch, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 126
BP 37S
EP 37S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000121
ER
PT J
AU Graybeal, CM
Plitt, A
Choi, DC
Saksida, LM
Bussey, TJ
Theberge, FRM
Lui, QR
Shaham, Y
Ressler, KJ
Holmes, A
AF Graybeal, Carolyn M.
Plitt, Aaron
Choi, Dennis C.
Saksida, Lisa M.
Bussey, Timothy J.
Theberge, Florence R. M.
Lui, Qing-Rong
Shaham, Yavin
Ressler, Kerry J.
Holmes, Andrew
TI The Role of Prefrontal Brain-Derived Neurotrophic Factor in Modulating
Stress-induced Facilitation of Reversal Learning
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Reversal learning; Stress; Brain-derived neurotrophic factor; Executive
function
C1 [Graybeal, Carolyn M.; Plitt, Aaron; Holmes, Andrew] NIAAA, NIH, Rockville, DC USA.
[Choi, Dennis C.; Ressler, Kerry J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
[Saksida, Lisa M.; Bussey, Timothy J.] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
[Theberge, Florence R. M.; Lui, Qing-Rong; Shaham, Yavin] NIDA, NIH, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 129
BP 38S
EP 38S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000124
ER
PT J
AU Daut, RA
DeBrouse, LM
Noronha, B
Holmes, A
AF Daut, Rachel A.
DeBrouse, Lauren M.
Noronha, Bianca
Holmes, Andrew
TI Effects of Chronic Intermittent Ethanol Exposure on Discrimination and
Reversal Learning in Mice
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE ethanol; cognitive flexibility; touchscreen; discrimination; reversal
C1 [Daut, Rachel A.; DeBrouse, Lauren M.; Noronha, Bianca; Holmes, Andrew] NIAAA, Lab Behav & Genom Neurosci, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 141
BP 42S
EP 42S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000136
ER
PT J
AU Myal, S
Wang, B
Wise, RA
AF Myal, Stephanie
Wang, Bin
Wise, Roy A.
TI Extinction with Cocaine Methiodide Attenuates Priming-Induced, but not
Footshock-Induced, Reinstatement of Cocaine Seeking
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE cocaine; self-administration; stress; addiction; drug abuse
C1 [Myal, Stephanie; Wang, Bin; Wise, Roy A.] NIDA, Behav Neurosci Res Branch, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 142
BP 42S
EP 43S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000137
ER
PT J
AU Tripp, AC
Oh, H
Guilloux, JP
Martinowich, K
Lewis, D
Sibille, EL
AF Tripp, Adam C.
Oh, Hyunjung
Guilloux, Jean-Philippe
Martinowich, Keri
Lewis, David
Sibille, Etienne L.
TI BDNF- and GABA- Related Gene Dysregulation in the Anterior Cingulate
Cortex in Major Depressive Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE BDNF; GABA; Anterior Cingulate Cortex; postmortem subjects; mouse model
C1 [Oh, Hyunjung; Lewis, David; Sibille, Etienne L.] Univ Pittsburgh, Med Ctr, Ctr Neurosci, Pittsburgh, PA USA.
[Guilloux, Jean-Philippe] Univ Paris 11, Paris, France.
[Martinowich, Keri] NIMH, Genes Cognit & Psychosis Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 169
BP 51S
EP 51S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000164
ER
PT J
AU Masdeu, JC
Gonzalez-Pinto, A
Matute, C
Ruiz-de-Azua, S
Palomino, A
De Leon, J
Dalmau, J
AF Masdeu, Joseph C.
Gonzalez-Pinto, Ana
Matute, Carlos
Ruiz-de-Azua, Sonia
Palomino, Aitor
De Leon, Jose
Dalmau, Josep
TI Serum IgG Antibodies Against the NMDA Receptor Not Detected in
Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; NMDA receptor; Antibodies
C1 [Masdeu, Joseph C.] NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA.
[Gonzalez-Pinto, Ana; Ruiz-de-Azua, Sonia] Univ Basque Country, Biomed Res Ctr Mental Hlth Net CIBERSAM, Santiago Apostol Hosp, Vitoria, Spain.
[Matute, Carlos; Palomino, Aitor] Univ Basque Country, CIBERNED, Dept Neurociencias, Fac Med, Leioa, Spain.
[De Leon, Jose] Univ Kentucky, Dept Psychiat, Lexington, KY USA.
[Dalmau, Josep] Univ Barcelona, ICREA, IDIBAPS, Neurol Serv,Hosp Clin, Barcelona, Spain.
RI de Leon, Jose/F-2709-2013
OI de Leon, Jose/0000-0002-7756-2314
NR 0
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 175
BP 53S
EP 53S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000170
ER
PT J
AU Paterson, C
Wang, YH
Law, AJ
AF Paterson, Clare
Wang, Yanhong
Law, Amanda J.
TI Cellular, Regional and Biochemical Characterization of Neuregulin 3 in
the CNS: Implications for a Functional Role in Schizophrenia
Pathophysiology
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; Neuregulin; Neurodevelopment; PIK3
C1 [Paterson, Clare; Wang, Yanhong; Law, Amanda J.] NIMH, NIH, Bethesda, MD 20892 USA.
RI Law, Amanda/G-6372-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 176
BP 53S
EP 53S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000171
ER
PT J
AU Machado-Vieira, R
Luckenbaugh, DA
Soeiro-De-Souza, MG
Busnello, JV
Gattaz, WF
Zarate, CA
AF Machado-Vieira, Rodrigo
Luckenbaugh, David A.
Soeiro-De-Souza, Marcia G.
Busnello, Joao V.
Gattaz, Wagner F.
Zarate, Carlos A., Jr.
TI Early Improvement with Lithium in Classic Mania Predicts Later Response
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE mania; bipolar disorder; lithium; clinical trial; predictors
C1 [Machado-Vieira, Rodrigo; Gattaz, Wagner F.] Univ Sao Paulo, Inst Psychiat, Sao Paulo, Brazil.
[Machado-Vieira, Rodrigo; Soeiro-De-Souza, Marcia G.; Gattaz, Wagner F.] Univ Sao Paulo, Dept Psychiat, Sao Paulo, Brazil.
[Luckenbaugh, David A.; Zarate, Carlos A., Jr.] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA.
[Busnello, Joao V.] Univ Chicago, Dept Psychiat, Sao Paulo, IL USA.
RI MACHADO-VIEIRA, RODRIGO/D-8293-2012; Gattaz, Wagner/C-4456-2012
OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190;
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 191
BP 58S
EP 58S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000186
ER
PT J
AU Yates, W
Feighery, EL
Mattay, VS
Apud, JA
Berman, KF
Weinberger, DR
Callicott, JH
AF Yates, William
Feighery, Emer L.
Mattay, Venkata S.
Apud, Jose A.
Berman, Karen F.
Weinberger, Daniel R.
Callicott, Joseph H.
TI Is the Prefrontal Inefficiency Phenotype in Schizophrenic Patients
Present in an Un-Medicated State?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; Working Memory; Inefficiency; fMRI
C1 [Yates, William; Feighery, Emer L.; Mattay, Venkata S.; Apud, Jose A.; Berman, Karen F.; Callicott, Joseph H.] NIMH, Clin Brain Disorders Branch, DIRP, NIH, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 206
BP 63S
EP 63S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000201
ER
PT J
AU Fortgang, R
Owrutsky, Z
Weinberger, DR
Dickinson, D
AF Fortgang, Rebecca
Owrutsky, Zoe
Weinberger, Daniel R.
Dickinson, Dwight
TI Suicidality and Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; Suicide; Self-Injury
C1 [Fortgang, Rebecca; Weinberger, Daniel R.; Dickinson, Dwight] NIMH, CBDB, Bethesda, MD 20892 USA.
[Owrutsky, Zoe] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 209
BP 64S
EP 64S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000204
ER
PT J
AU Schaefer, JD
Weinberger, DR
Dickinson, D
AF Schaefer, Jonathan D.
Weinberger, Daniel R.
Dickinson, Dwight
TI Generalized Cognitive Impairment in Schizophrenia: An Update and
Extension of Previous Meta-Analyses
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE schizophrenia; meta-analysis; cognitive; impairment; generalized
C1 [Schaefer, Jonathan D.; Weinberger, Daniel R.; Dickinson, Dwight] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 210
BP 64S
EP 65S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000205
ER
PT J
AU Costa, VD
Averbeck, BB
AF Costa, Vincent D.
Averbeck, Bruno B.
TI Emotional Perception Modulates Activity in the Human Periaqueductal Gray
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE emotion; fMRI; periaqueductal gray; amygdala; perception
C1 [Costa, Vincent D.; Averbeck, Bruno B.] NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 219
BP 67S
EP 67S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000214
ER
PT J
AU Romer, AL
Jarcho, JM
Shechner, T
Pine, DS
Nelson, EE
AF Romer, Adrienne L.
Jarcho, Johanna M.
Shechner, Tomer
Pine, Daniel S.
Nelson, Eric E.
TI Socially-Driven Cognitive Biases in Expectations and Recall of Peer
Rejection in Anxiety
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE cognitive biases; anxiety; self-esteem; peer rejection; chatroom
C1 [Romer, Adrienne L.; Jarcho, Johanna M.; Shechner, Tomer; Pine, Daniel S.; Nelson, Eric E.] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 218
BP 67S
EP 67S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000213
ER
PT J
AU Adalio, CJ
White, SF
Fowler, KA
Sinclair, S
Pine, DS
Blair, RJR
AF Adalio, Christopher J.
White, Stuart F.
Fowler, Katherine A.
Sinclair, Stephen
Pine, Daniel S.
Blair, R. J. R.
TI Youth with Disruptive Behavior Disorders and Callous-Unemotional Traits
Show Impaired Neural Representation of Expected Value
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Disruptive Behavior Disorder; Conduct Disorder; Decision-making; fMRl
C1 [Adalio, Christopher J.; White, Stuart F.; Sinclair, Stephen; Blair, R. J. R.] NIMH, Unit Affect Cognit Neurosci, Bethesda, MD 20892 USA.
[Fowler, Katherine A.] Epidem Intelligence Serv, CDC, Atlanta, GA USA.
[Pine, Daniel S.] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 232
BP 71S
EP 72S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000227
ER
PT J
AU White, S
Fowler, K
Sinclair, S
Pine, DS
Blair, JR
AF White, Stuart
Fowler, Katherine
Sinclair, Stephen
Pine, Daniel S.
Blair, James R.
TI Youth with Disruptive Behavior Disorders and Callous-Unemotional Traits
Show Impaired Neural Representation of Expected Value
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Conduct Disorder; Callous-Unemotional Traits; neuroscience; learning
C1 [White, Stuart; Fowler, Katherine; Sinclair, Stephen; Blair, James R.] NIMH, Unit Affect Cognit Neurosci, Bethesda, MD 20892 USA.
[Pine, Daniel S.] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 231
BP 71S
EP 71S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000226
ER
PT J
AU Franco-Chaves, JA
Mateus, CF
Letkiewicz, AM
Leberman, LN
Zarate, CA
Grillon, C
AF Franco-Chaves, Jose A.
Mateus, Camilo F.
Letkiewicz, Allison M.
Leberman, Lynne N.
Zarate, Carlos A.
Grillon, Christian
TI Increased Startle to Contextual Threat in Unipolar Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Startle; Depression; Contextual Threat
C1 [Franco-Chaves, Jose A.; Mateus, Camilo F.; Zarate, Carlos A.] NIMH, ETPB, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 252
BP 78S
EP 78S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000247
ER
PT J
AU Hochheiser, J
Deep-Soboslay, A
Dickinson, D
Bliss, L
Apud, J
Weinberger, D
Hyde, T
AF Hochheiser, Jesse
Deep-Soboslay, Amy
Dickinson, Dwight
Bliss, Lindsay
Apud, Jose
Weinberger, Daniel
Hyde, Thomas
TI Complex Motor Sequencing Deficits are Associated with Specific Cognitive
Abnormalities among Patients with Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE complex motor sequencing; schizophrenia; neurological evaluation scale;
neuropsychological; frontostriatal
C1 [Hochheiser, Jesse; Deep-Soboslay, Amy; Dickinson, Dwight; Bliss, Lindsay; Apud, Jose; Weinberger, Daniel; Hyde, Thomas] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Weinberger, Daniel; Hyde, Thomas] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 284
BP 88S
EP 88S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000279
ER
PT J
AU David, CN
Maher, K
Tan, M
Tossell, J
Weisinger, B
Gochman, P
Miller, R
Greenstein, D
Overman, G
Rapoport, JL
Gogtay, N
AF David, Christopher N.
Maher, Kirstin
Tan, Marcus
Tossell, Julia
Weisinger, Brian
Gochman, Peter
Miller, Rachel
Greenstein, Deanna
Overman, Gerald
Rapoport, Judith L.
Gogtay, Nitin
TI Risk Factors for Neutropenia in Clozapine-Treated Children and
Adolescents with Childhood-Onset Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE clozapine; neutropenia; childhood-onset schizophrenia
C1 [David, Christopher N.; Maher, Kirstin; Tan, Marcus; Tossell, Julia; Weisinger, Brian; Gochman, Peter; Miller, Rachel; Greenstein, Deanna; Overman, Gerald; Rapoport, Judith L.; Gogtay, Nitin] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 329
BP 102S
EP 102S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000324
ER
PT J
AU Ungerleider, LG
AF Ungerleider, Leslie G.
TI Circuits Mediating Different Psychological Domains - Face Perception
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
ID TEMPORAL CORTEX; SELECTIVITY
C1 [Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
NR 5
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 346
BP 108S
EP 108S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000341
ER
PT J
AU Hibbeln, J
AF Hibbeln, Joseph
TI Suicide Deaths of Active-Duty US Military and Omega-3. Fatty-Acid
Status: A Case-Control Comparison
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Hibbeln, Joseph] NIAAA, Rockville, MD 20852 USA.
NR 0
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 366
BP 114S
EP 114S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000361
ER
PT J
AU Rapoport, SI
AF Rapoport, Stanley I.
TI Evidence for a Role of Arachidonic Acid in Bipolar Disorders and its
Treatment
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Rapoport, Stanley I.] NIA, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 365
BP 114S
EP 114S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000360
ER
PT J
AU Gogtay, N
AF Gogtay, Nitin
TI Exploring Neurodevelopmental Networks in Childhood Onset Schizophrenia:
An Overview from Structural Neuroimaging
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE childhood; schizophrenia; neuroimaging
C1 [Gogtay, Nitin] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 375
BP 116S
EP 117S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000370
ER
PT J
AU James, B
AF James, Blair
TI The Neuro-Computational Underpinnings of the Decision-Making Deficit in
Conduct Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Conduct Disorder; Amygdala; Prediction error; Expected value;
Ventromedial prefrontal cortex
C1 [James, Blair] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 409
BP 127S
EP 127S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000404
ER
PT J
AU Cornwell, BR
AF Cornwell, Brian R.
TI Evidence that Cortical Plasticity Underlies Ketamine's Rapid
Antidepressant Action
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE cortical excitability; gamma oscillation; ketamine; major depression;
magnetoencephalography
C1 [Cornwell, Brian R.] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 419
BP 130S
EP 130S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000414
ER
PT J
AU Blair, KS
Teng, CY
Geraci, M
Blair, J
Pine, DS
AF Blair, Karina S.
Teng, Cindy Y.
Geraci, Marilla
Blair, James
Pine, Daniel S.
TI Reduced Dorsal Anterior Cingulate Cortical Activity during Explicit
Emotional Regulation and as a Function of Top Down Attentional Control
in Generalized Social Phobia (GSP), Generalized Anxiety Disorder (GAD)
and Comorbid GSP/GAD
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE social phobia; generalized anxiety disorder; emotional regulation; fMRI;
attention
C1 [Blair, Karina S.; Teng, Cindy Y.; Geraci, Marilla; Blair, James; Pine, Daniel S.] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 433
BP 134S
EP 135S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000428
ER
PT J
AU Geerlings, MI
Sigurdsson, S
Eiriksdottir, G
Garcia, ME
Harris, TB
Gudnason, V
Launer, LJ
AF Geerlings, Mirjam I.
Sigurdsson, Sigurdur
Eiriksdottir, Gudny
Garcia, Melissa E.
Harris, Tamara B.
Gudnason, Vilmundur
Launer, Lenore J.
TI Major Depressive Disorder, Salivary Cortisol, and Brain Atrophy in a
Population-Based Cohort of Old Persons without Dementia. The
AGES-Reykjavik Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE brain; cortisol; depression; MRI; population-based
C1 [Geerlings, Mirjam I.; Garcia, Melissa E.; Harris, Tamara B.; Launer, Lenore J.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
[Geerlings, Mirjam I.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
[Sigurdsson, Sigurdur; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland.
[Gudnason, Vilmundur] Univ Iceland, Reykjavik, Iceland.
RI Gudnason, Vilmundur/K-6885-2015
OI Gudnason, Vilmundur/0000-0001-5696-0084
NR 0
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 446
BP 139S
EP 139S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000441
ER
PT J
AU Murphy, E
Hawariat, G
McMahon, F
AF Murphy, Eleanor
Hawariat, Girma
McMahon, Francis
TI Genetic Ancestry, Self-Reported Race and Therapeutic Response to
Antidepressant Medication: Additional highlights from the STAR(star)D
Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Psychopharmacology; Ethnicity; Genetics; Depression; Disparity
C1 [Murphy, Eleanor; Hawariat, Girma; McMahon, Francis] NIH, Human Genet Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 447
BP 139S
EP 140S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000442
ER
PT J
AU Flynn, S
Cinar, OG
Sibille, E
Holmes, A
AF Flynn, Shaun
Cinar, Ozge Gunduz
Sibille, Etienne
Holmes, Andrew
TI Amygdala Gene Networks Associated with Mouse Trait Differences in Fear
Extinction
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE impaired extinction; behavior; fear; gene expressions; stress
C1 [Flynn, Shaun; Cinar, Ozge Gunduz; Holmes, Andrew] NIAAA, Lab Behav & Genom Neurosci, Bethesda, MD 15260 USA.
[Sibille, Etienne] Univ Pittsburgh, Ctr Neurosci, Dept Psychiat, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 465
BP 145S
EP 145S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000460
ER
PT J
AU Palumbo, S
Law, A
AF Palumbo, Sara
Law, Amanda
TI AKT-2 Heterozygous Mice Exhibit a Unique Behavioral Phenotype Relevant
to Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE AKT-2; schizophrenia; behavior; mouse; heterozygous
C1 [Palumbo, Sara; Law, Amanda] NIH, Clin Brain Disorder Branch, Bethesda, MD 20892 USA.
RI Law, Amanda/G-6372-2012; palumbo, sara/B-1603-2013
OI palumbo, sara/0000-0002-3809-6058
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 466
BP 145S
EP 145S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000461
ER
PT J
AU Kolata, S
Rompala, G
Jiang, ZH
Nakao, K
Paredes, DA
Nakazawa, K
AF Kolata, Stefan
Rompala, Gregory
Jiang, Zhihong
Nakao, Kazuhito
Paredes, Daniel A.
Nakazawa, Kazu
TI Postnatal Gad67 Ablation in a Subset of Corticolimbic Interneurons
Confers an Anhedonia-Like Phenotype
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Gad67; Interneurons; Anhedonia; Dopamine; Social Withdrawal
C1 [Kolata, Stefan; Rompala, Gregory; Jiang, Zhihong; Nakao, Kazuhito; Nakazawa, Kazu] NIMH, NIH, Bethesda, MD 20892 USA.
[Paredes, Daniel A.] NINDS, NIH, Bethesda, MD 20892 USA.
RI Paredes , Daniel/L-6610-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 467
BP 146S
EP 146S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000462
ER
PT J
AU Nakao, K
Nakazawa, K
AF Nakao, Kazuhito
Nakazawa, Kazu
TI Postnatal NMDA Receptor Deletion in Corticolimbic GABAergic Interneurons
Attenuates Gamma Oscillation
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE NMDA; gamma oscillatory; internueron; auditory cortex; somatosensory
cortex
C1 [Nakao, Kazuhito; Nakazawa, Kazu] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 468
BP 146S
EP 146S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000463
ER
PT J
AU New, AS
Perez-Rodriguez, MM
Ripoll, L
Bevilacqua, L
Yuan, QP
Zhou, ZF
Hodgkinson, C
Goodman, M
Koenigsberg, HW
Goldman, D
Siever, LJ
AF New, Antonia S.
Perez-Rodriguez, M. Mercedes
Ripoll, Luis
Bevilacqua, Laura
Yuan, Qiaoping
Zhou, Zhifeng
Hodgkinson, Colin
Goodman, Marianne
Koenigsberg, Harold W.
Goldman, David
Siever, Larry J.
TI Genetic Variation in OPRM1 Gene and Anxious Attachment in Personality
Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Opioid; attachment; borderline personality; interpersonal; genetic
C1 [New, Antonia S.; Perez-Rodriguez, M. Mercedes; Ripoll, Luis; Goodman, Marianne; Koenigsberg, Harold W.; Siever, Larry J.] Mt Sinai Sch Med, New York, NY USA.
[Bevilacqua, Laura; Yuan, Qiaoping; Zhou, Zhifeng; Hodgkinson, Colin; Goldman, David] NIAAA, Neurogenet Lab, Washington, DC USA.
RI Perez Rodriguez, Maria/B-9410-2013
OI Perez Rodriguez, Maria/0000-0001-5137-1993
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 491
BP 154S
EP 155S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000486
ER
PT J
AU Perez-Rodriguez, MM
Roussos, P
Bevilacqua, L
Yuan, QP
Zhou, ZF
Hodgkinson, C
Ripoll, L
Goodman, M
Koenigsberg, HW
Goldman, D
Siever, LJ
New, AS
AF Perez-Rodriguez, M. Mercedes
Roussos, Panos
Bevilacqua, Laura
Yuan, Qiaoping
Zhou, Zhifeng
Hodgkinson, Colin
Ripoll, Luis
Goodman, Marianne
Koenigsberg, Harold W.
Goldman, David
Siever, Larry J.
New, Antonia S.
TI Exploratory Association Study of 130 Candidate Genes in Patients with
Borderline Personality Disorder and Healthy Controls
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Borderline Personality Disorder; Genetics; Dopamine beta hydroxylase;
Association study
C1 [Perez-Rodriguez, M. Mercedes; Roussos, Panos; Ripoll, Luis; Goodman, Marianne; Koenigsberg, Harold W.; Siever, Larry J.; New, Antonia S.] Mt Sinai Sch Med, New York, NY USA.
[Perez-Rodriguez, M. Mercedes; Roussos, Panos; Ripoll, Luis; Goodman, Marianne; Koenigsberg, Harold W.; Siever, Larry J.; New, Antonia S.] James J Peters Vet Affairs Med Ctr, Mental Hlth Patient Care Ctr, Bronx, NY USA.
[Bevilacqua, Laura; Yuan, Qiaoping; Zhou, Zhifeng; Hodgkinson, Colin; Goldman, David] NIAAA, Neurogenet Lab, NIH, Rockville, MD 20852 USA.
RI Perez Rodriguez, Maria/B-9410-2013; Roussos, Panos/J-7090-2013
OI Perez Rodriguez, Maria/0000-0001-5137-1993; Roussos,
Panos/0000-0002-4640-6239
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 492
BP 155S
EP 155S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000487
ER
PT J
AU Chen, DT
Akula, N
Hou, LP
Hawariat, G
Detera-Wadleigh, S
Jiang, X
McMahon, FJ
AF Chen, David T.
Akula, Nirmala
Hou, Liping
Hawariat, Girma
Detera-Wadleigh, Sevilla
Jiang, Xueying
McMahon, Francis J.
CA BIGS Consortium
TI Genome-Wide Association Signals in Bipolar Disorder are Enriched for
Genetic Variants within Transcription Factor Binding Sites and
Expression Quantitative Trait Loci
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE bipolar disorder; transcription factor binding site; cis-regulation;
enrichment
C1 [Chen, David T.; Akula, Nirmala; Hou, Liping; Hawariat, Girma; Detera-Wadleigh, Sevilla; Jiang, Xueying; McMahon, Francis J.] NIMH, Human Genet Branch, NIH, Bethesda, MD 20892 USA.
[BIGS Consortium] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
RI Hou, Liping/G-1648-2011
OI Hou, Liping/0000-0003-3972-245X
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 496
BP 156S
EP 156S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000491
ER
PT J
AU Zheutlin, AB
Callicotti, JH
Yates, WD
Chen, Q
Weinberger, DR
Wang, KH
AF Zheutlin, Amanda B.
Callicotti, Joseph H.
Yates, William D.
Chen, Qiang
Weinberger, Daniel R.
Wang, Kuan H.
TI ARC Genotype Predicts Prefrontal Efficiency and Connectivity Between
Prefrontal Cortex and Hippocampus
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE schizophrenia; cunnectivity; prefrontal cortex; genetics; ARC
C1 [Zheutlin, Amanda B.; Callicotti, Joseph H.; Yates, William D.; Chen, Qiang; Wang, Kuan H.] NIMH, Clin Brain Disorders Branch, DIRP, NIH, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 501
BP 158S
EP 158S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000496
ER
PT J
AU Baranger, DAA
Yates, WD
Chen, Q
Mattay, VS
Weinberger, DR
Callicott, JH
AF Baranger, David A. A.
Yates, William D.
Chen, Qiang
Mattay, Venkata S.
Weinberger, Daniel R.
Callicott, Joseph H.
TI Disci Leu607Phe and Ser704Cys Reduce Prefrontal-Hippocampal Coupling
During a Working Memory Task
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE DISCI; Connectivity; Schizophrenia; Working Memory; Hippocampus
C1 [Baranger, David A. A.; Yates, William D.; Chen, Qiang; Mattay, Venkata S.; Weinberger, Daniel R.; Callicott, Joseph H.] NIMH, Genes Cognit & Psychosis Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 507
BP 160S
EP 160S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000502
ER
PT J
AU Wallwork, RS
Straub, RE
Weinberger, DR
Dickinson, D
AF Wallwork, Rachel S.
Straub, Richard E.
Weinberger, Daniel R.
Dickinson, Dwight
TI Investigation of The Relationship of KYNU and Cortical Kynurenine
Pathway Metabolism to Cognition in Schizophrenia and Healthy Volunteers
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Kynurenine; cognition; schizophrenia
C1 [Wallwork, Rachel S.; Straub, Richard E.; Dickinson, Dwight] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] Johns Hopkins Med Ctr, Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 513
BP 162S
EP 162S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000508
ER
PT J
AU Enoch, MA
Zhou, ZF
Mash, DC
Yuan, QP
Goldman, D
Sinha, R
AF Enoch, Mary-Anne
Zhou, Zhifeng
Mash, Deborah C.
Yuan, Qiaoping
Goldman, David
Sinha, Rajita
TI Genetic Influences on HPA Axis Reactivity and Hippocampal Expression of
Stress-Related Genes in Alcoholics and Cocaine Addicts
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE cortisol; CRH; CRHBP; FKBP5; NPY
C1 [Enoch, Mary-Anne; Zhou, Zhifeng; Yuan, Qiaoping; Goldman, David] NIAAA, LNG, NIH, Bethesda, MD USA.
[Mash, Deborah C.] Univ Miami, Sch Med, Dept Neurol, Miami, FL USA.
[Sinha, Rajita] Yale Univ, Sch Med, Yale Stress Ctr, New Haven, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 516
BP 163S
EP 163S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000511
ER
PT J
AU Damme, KSF
Wei, SM
Baller, EB
Bloch, JB
Kohn, PD
Kippenhan, JS
Rubinow, DR
Martinez, P
Schmidt, PJ
Berman, KF
AF Damme, Katherine S. F.
Wei, Shau-Ming
Baller, Erica B.
Bloch, Jeff B.
Kohn, Philip D.
Kippenhan, Jonathon S.
Rubinow, David R.
Martinez, Pedro
Schmidt, Peter J.
Berman, Karen F.
TI Ovarian Hormones Modulate Age-Related Changes in rCBF during Working
Memory - A Positron Emission Tomography (PET) Study in Women
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Imaging; Healthy Aging; Estrogen; Hippocampus; PET
C1 [Damme, Katherine S. F.; Wei, Shau-Ming; Baller, Erica B.; Bloch, Jeff B.; Kohn, Philip D.; Kippenhan, Jonathon S.; Martinez, Pedro; Schmidt, Peter J.; Berman, Karen F.] NIMH, Bethesda, MD 20892 USA.
[Rubinow, David R.] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 540
BP 170S
EP 170S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000535
ER
PT J
AU Killgore, WDS
Britton, JC
Rosso, IM
Schwab, ZJ
Rauch, SL
AF Killgore, William D. S.
Britton, Jennifer C.
Rosso, Isabelle M.
Schwab, Zachary J.
Rauch, Scott L.
TI Shared and Unique Patterns of Cortico-Limbic Activation Across Anxiety
Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Neuroimaging; Panic Disorder; PTSD; Phobia; Amygdala
C1 [Killgore, William D. S.; Rosso, Isabelle M.; Schwab, Zachary J.; Rauch, Scott L.] McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA 02178 USA.
[Britton, Jennifer C.] NIMH, NIH, Bethesda, MD 20892 USA.
RI Britton, Jennifer/J-4501-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 549
BP 173S
EP 173S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000544
ER
PT J
AU Roy, A
Carlisi, C
Daniele, T
Pine, D
Ernst, M
AF Roy, Amy
Carlisi, Christina
Daniele, Teresa
Pine, Daniel
Ernst, Monique
TI Val/Met Polymorphism of the BDNF Gene and Altered Resting-State
Functional Connectivity in Healthy Adults
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Resting-State; BDNF; fMRI; Anxiety; Connectivity
C1 [Roy, Amy] Fordham Univ, Dept Psychol, Bronx, NY 10458 USA.
[Carlisi, Christina; Daniele, Teresa; Pine, Daniel; Ernst, Monique] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 551
BP 173S
EP 174S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000546
ER
PT J
AU Blair, KS
Teng, CY
Geraci, M
Blair, J
Pine, DS
AF Blair, Karina S.
Teng, Cindy Y.
Geraci, Marilla
Blair, James
Pine, Daniel S.
TI A fMRI Investigation of Reduced Optimism and Reduced Optimistic Bias in
Generalized Anxiety Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE generalized anxiety disorder; optimistic bias; fMRI; prefrontal cortex;
optimism
C1 [Blair, Karina S.; Teng, Cindy Y.; Geraci, Marilla; Blair, James; Pine, Daniel S.] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 553
BP 174S
EP 174S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000548
ER
PT J
AU Vytal, KE
Overstreet, C
Robinson, O
Grillon, C
AF Vytal, Katherine E.
Overstreet, Cassie
Robinson, Oliver
Grillon, Christian
TI Exploring the Anxious Brain at Rest: Subcortico-Frontal Connectivity
Changes Associated with an Anxious State
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Anxiety; Resting State; Connectivity
C1 [Vytal, Katherine E.; Overstreet, Cassie; Robinson, Oliver; Grillon, Christian] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 554
BP 175S
EP 175S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000549
ER
PT J
AU Ariza, VL
Seguin, JR
Nassim, M
Rainville, P
Boivin, M
Pine, DS
Lepore, F
Tremblay, RE
Maheu, F
AF Ariza, Valerie La Buissonniere
Seguin, Jean R.
Nassim, Marouane
Rainville, Pierre
Boivin, Michel
Pine, Daniel S.
Lepore, Franco
Tremblay, Richard E.
Maheu, Francoise
TI Harsh Parenting and Neural Fear Circuitry Function in High and Low
Anxious Youths: Preliminary Findings
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE anxiety; harsh parenting; fMRI; fear circuitry; conditioning
C1 [Ariza, Valerie La Buissonniere; Seguin, Jean R.; Rainville, Pierre; Lepore, Franco; Tremblay, Richard E.; Maheu, Francoise] Univ Montreal, Montreal, PQ, Canada.
[Ariza, Valerie La Buissonniere; Seguin, Jean R.; Maheu, Francoise] CHU Ste Justine, Res Ctr, Montreal, PQ, Canada.
[Boivin, Michel] Univ Laval, Quebec City, PQ, Canada.
[Pine, Daniel S.] NIMH, Emot Dev & Affect Neurosci Sect, Bethesda, MD 20892 USA.
RI Seguin, Jean/B-5349-2008; Boivin, Michel/J-3652-2013; Tremblay,
Richard/O-1360-2014
OI Seguin, Jean/0000-0003-3359-6202;
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 564
BP 178S
EP 178S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000559
ER
PT J
AU DeJong, K
Kamath, T
Chandramohan, D
Kippenhan, S
Roe, K
Padmanabhan, A
Kohn, P
Mervis, C
Pani, A
Morris, C
Weinberger, D
Pierpaoli, C
Marenco, S
Berman, K
AF DeJong, Katherine
Kamath, Tushar
Chandramohan, Dharshan
Kippenhan, Shane
Roe, Katherine
Padmanabhan, Aarthi
Kohn, Phillip
Mervis, Carolyn
Pani, Ariel
Morris, Colleen
Weinberger, Daniel
Pierpaoli, Carlo
Marenco, Stefano
Berman, Karen
TI Altered Tract Volume in Participants with Partial Deletions of the
William Syndrome Chromosome Region
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Williams Syndrome; Diffusion Tensor Imaging; White matter
C1 [DeJong, Katherine; Kamath, Tushar; Chandramohan, Dharshan; Marenco, Stefano] NIMH, Unit Multimodal Imaging Genet, CBDB, Bethesda, MD 20892 USA.
[Kippenhan, Shane; Roe, Katherine; Padmanabhan, Aarthi; Kohn, Phillip; Berman, Karen] NIMH, Sect Integrat Neuroimaging, Bethesda, MD 20892 USA.
[Mervis, Carolyn] Univ Louisville, Dept Psychol & Brain Sci, Neurodev Sci Lab, Louisville, KY 40292 USA.
[Pani, Ariel] Stanford Univ, Dept Biol, Hopkins Marine Stn, Pacific Grove, CA USA.
[Morris, Colleen] Univ Nevada, Sch Med, Dept Pediat, Div Genet, Las Vegas, NV 89154 USA.
[Weinberger, Daniel] NIMH, GCAP CBDB, Bethesda, MD 20892 USA.
[Pierpaoli, Carlo] NICHHD, Sect Tissue Biophys & Biomimet, Bethesda, MD 20892 USA.
RI Marenco, Stefano/A-2409-2008
OI Marenco, Stefano/0000-0002-2488-2365
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 573
BP 181S
EP 181S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000568
ER
PT J
AU Gambale, CT
Marenco, S
Chandramohan, D
Kippenhan, S
Tost, H
Lemaitre, H
Kolachana, B
Weinberger, DR
Berman, KF
AF Gambale, Catherine T.
Marenco, Stefano
Chandramohan, Dharshan
Kippenhan, Shane
Tost, Heike
Lemaitre, Herve'
Kolachana, Bhaskar
Weinberger, Daniel R.
Berman, Karen F.
TI Association of a Single Nucleotide Polymorphism in LIMK1 with Diffusion
Tensor Imaging (DTI) Measures
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE LIMK1; DTI; Williams; rs710969
C1 [Gambale, Catherine T.; Marenco, Stefano; Chandramohan, Dharshan; Tost, Heike; Lemaitre, Herve'; Kolachana, Bhaskar] NIMH, Clin Brain Disorders Branch Unit Multimodal Imagi, Bethesda, MD 20892 USA.
[Kippenhan, Shane; Berman, Karen F.] NIMH, Sect Integrat Neuroimaging, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] NIMH, GCAP CBDB, NIMH IRP, Bethesda, MD 20892 USA.
RI Marenco, Stefano/A-2409-2008
OI Marenco, Stefano/0000-0002-2488-2365
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 574
BP 181S
EP 181S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000569
ER
PT J
AU Lee, NR
Raznahan, A
Adeyemi, EI
Hanley, A
Clasen, LS
Blumenthal, J
Giedd, JN
AF Lee, Nancy Raitano
Raznahan, Armin
Adeyemi, Elizabeth I.
Hanley, Allison
Clasen, Liv S.
Blumenthal, Jonathan
Giedd, Jay N.
TI A Preliminary Investigation of Cortical Thickness and Surface Area in
XYY: A Possible Genetic Model for Psychiatric Disorders Characterized by
Social Cognitive Impairment?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE sex chromosome; magnetic resonance imaging; XYY; cortical thickness;
cortical surface area
C1 [Lee, Nancy Raitano; Raznahan, Armin; Adeyemi, Elizabeth I.; Hanley, Allison; Clasen, Liv S.; Blumenthal, Jonathan; Giedd, Jay N.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
RI Raznahan, Armin/F-4534-2012; Giedd, Jay/B-7302-2012; Giedd,
Jay/J-9644-2015; Lee, Nancy/M-7492-2016
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978; Lee,
Nancy/0000-0002-6663-0713
NR 0
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 589
BP 186S
EP 187S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000584
ER
PT J
AU Lee, MR
Wu, WY
Salmeron, BJ
Gallen, C
Yang, YH
AF Lee, Mary R.
Wu, Weiyue
Salmeron, Betty Jo
Gallen, Courtney
Yang, Yihong
TI The Effect of the COMT Val158Met Genotype and Early Life Stress on Brain
Structure in Healthy Volunteers
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Childhood trauma; COMT; MRI; brain volume; insula
C1 [Lee, Mary R.; Wu, Weiyue; Salmeron, Betty Jo; Gallen, Courtney; Yang, Yihong] Natl Inst Drug Abuse, Neuroimaging Res Branch, Baltimore, MD USA.
RI Salmeron, Betty Jo/M-1793-2016
OI Salmeron, Betty Jo/0000-0003-1699-9333
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 590
BP 187S
EP 187S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000585
ER
PT J
AU Raznahan, A
Lenroot, R
Thurm, A
Gozzi, M
Spence, S
Giedd, JN
Swedo, S
AF Raznahan, Armin
Lenroot, Rhoshel
Thurm, Audrey
Gozzi, Marta
Spence, Sarah
Giedd, Jay N.
Swedo, Susan
TI Compared to What? Head Circumference Overgrowth Relative to Available
Population Norms does not Distinguish Infants with Autism from Typically
Developing Controls
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Autism; Head Circumference; Development
C1 [Raznahan, Armin; Lenroot, Rhoshel; Giedd, Jay N.] NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA.
[Thurm, Audrey; Gozzi, Marta; Swedo, Susan] NIMH, Pediat & Dev Neurosci Branch, NIH, Bethesda, MD 20892 USA.
[Spence, Sarah] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.
RI Raznahan, Armin/F-4534-2012; Giedd, Jay/B-7302-2012; Giedd,
Jay/J-9644-2015
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 592
BP 187S
EP 187S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000587
ER
PT J
AU Wallace, GL
Robustelli, B
Dankner, N
Kenworthy, L
Giedd, JN
Martin, A
AF Wallace, Gregory L.
Robustelli, Briana
Dankner, Nathan
Kenworthy, Lauren
Giedd, Jay N.
Martin, Alex
TI Increased Cortical Surface Area and Gyrification During Adolescence and
Young Adulthood in Autism Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE autism; imaging; MRI; surface area; gyrification
C1 [Wallace, Gregory L.; Robustelli, Briana; Dankner, Nathan; Kenworthy, Lauren; Giedd, Jay N.; Martin, Alex] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
RI martin, alex/B-6176-2009; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 591
BP 187S
EP 187S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000586
ER
PT J
AU Noronha, CM
Stockman, M
White, R
Lalonde, F
Diwadkar, VA
Gogtay, N
AF Noronha, Carol M.
Stockman, Michael
White, Richard
Lalonde, Francois
Diwadkar, Vaibhav A.
Gogtay, Nitin
TI Aberrant Activation During Visually Guided Finger Tapping in Childhood
Onset Schizophrenia: fMRI Evidence
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; Childhood-onset; fMRI; visuo-motor; activation
C1 [Noronha, Carol M.; White, Richard; Diwadkar, Vaibhav A.] Wayne State Univ, Sch Med, Brain Res & Imaging Neurosci Div, Dept Psychiat & Behav Neurosci, Detroit, MI USA.
[Stockman, Michael; Lalonde, Francois; Gogtay, Nitin] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 606
BP 192S
EP 193S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000601
ER
PT J
AU Bloch, JB
Wei, SM
Bailer, EB
Damme, KS
Martinez, PE
Kohn, PD
Kippenhan, JS
Rubinow, DR
Schmidt, PJ
Berman, KF
AF Bloch, Jeffrey B.
Wei, Shau-Ming
Bailer, Erica B.
Damme, Katherine S.
Martinez, Pedro E.
Kohn, Philip D.
Kippenhan, Jonathan S.
Rubinow, David R.
Schmidt, Peter J.
Berman, Karen F.
TI Ovarian Hormones Differentially Modulate Subgenual Cingulate and
Hippocampal Activity in Premenstrual Dysphoria at Rest - A Positron
Emission Tomography (PET) Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Premenstrual Dysphoria (PMD); Gonadal Hormones; Mood Disorder; PET; Rest
C1 [Bloch, Jeffrey B.; Wei, Shau-Ming; Bailer, Erica B.; Damme, Katherine S.; Kohn, Philip D.; Kippenhan, Jonathan S.; Berman, Karen F.] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Martinez, Pedro E.; Schmidt, Peter J.] NIMH, Sect Behav Endocrinol, Bethesda, MD 20892 USA.
[Rubinow, David R.] Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 629
BP 200S
EP 201S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000624
ER
PT J
AU Adlemon, NE
Razdan, V
Walker, L
Sarlls, J
Pierpaoli, C
Leibenluft, E
AF Adlemon, Nancy E.
Razdan, Varun
Walker, Lindsay
Sarlls, Joelle
Pierpaoli, Carlo
Leibenluft, Ellen
TI White Matter Integrity in Children with Bipolar Disorder and Severe Mood
Dysregulation
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE diffusion tensor imaging; bipolar disorder; severe mood dysregulation;
pediatric; brain
C1 [Adlemon, Nancy E.; Razdan, Varun; Leibenluft, Ellen] NIMH, NIH, Bethesda, MD 20892 USA.
[Walker, Lindsay; Pierpaoli, Carlo] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
[Sarlls, Joelle] NINDS, NIH MRI Res Facil, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 630
BP 201S
EP 201S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000625
ER
PT J
AU Malek, M
Watson, B
AF Malek, Meaghan
Watson, Bethany
TI Cortical Change in New Onset Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Depression; new onset; cortical change; at risk; cortical thickness
C1 [Malek, Meaghan; Watson, Bethany] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 631
BP 201S
EP 201S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466000626
ER
PT J
AU Insel, T
AF Insel, Thomas
TI New Frontiers: From Biological Psychiatry to Clinical Neuroscienc
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
ID HUMAN BRAIN
C1 [Insel, Thomas] NIMH, Bethesda, MD 20892 USA.
NR 3
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 682
BP 218S
EP 218S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001005
ER
PT J
AU Berman, K
AF Berman, Karen
TI Linking Imaging Phenotypes in Williams Syndrome to Genetic Mechanisms
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Berman, Karen] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 687
BP 220S
EP 220S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001010
ER
PT J
AU Lipska, BK
AF Lipska, Barbara K.
TI Postmortem Studies on Cortical Gene Expression in Williams Syndrome
Patients and in Normal Development
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Lipska, Barbara K.] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 688
BP 220S
EP 220S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001011
ER
PT J
AU Martin, A
AF Martin, Alex
TI Fractionating the Social Brain in Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Martin, Alex] NIMH, Bethesda, MD 20892 USA.
RI martin, alex/B-6176-2009
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 689
BP 220S
EP 220S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001012
ER
PT J
AU Barr, CS
AF Barr, Christina S.
TI Nonhuman Primate Models Afford Identification of Pathways and Critical
Windows During which Genetic Factors Contribute to Risk for
Stress-Psychiatric Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Barr, Christina S.] NIAAA, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 699
BP 223S
EP 223S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001022
ER
PT J
AU Deveney, C
AF Deveney, Christen
TI Neural Correlates of Frustration Among Youths with Severe Mood
Dysregulation
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Deveney, Christen] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 697
BP 223S
EP 223S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001020
ER
PT J
AU Raznahan, A
AF Raznahan, Armin
TI The Importance of Journey over Destination for Psychiatric Neuroimaging
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Raznahan, Armin] NIMH, NIH, Bethesda, MD 20892 USA.
RI Raznahan, Armin/F-4534-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 702B
BP 225S
EP 225S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001027
ER
PT J
AU Law, AJ
AF Law, Amanda J.
TI Genetic and Biological Epistasis Within the NRG1-ErbB4-PIK3CD Network.
Context Dependant Regulation of AKT and a Novel Therapeutic Target
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE NRG1; ErbB4; Schizophrenia; AKT; human brain
C1 [Law, Amanda J.] NIMH, NIH, Bethesda, MD 20892 USA.
RI Law, Amanda/G-6372-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 706
BP 226S
EP 226S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001031
ER
PT J
AU Weinberger, DR
AF Weinberger, Daniel R.
TI Epistatic Gene Networks in Hippocampal Plasticity and Schizophrenia Risk
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Weinberger, Daniel R.] NIMH, NIH, Inramural Res Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 705
BP 226S
EP 226S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001030
ER
PT J
AU Bonci, A
AF Bonci, Antonello
TI Optogenetic Investigation of the Reward System
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Bonci, Antonello] NIDA, NIH, Intramural Res Program, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 708
BP 227S
EP 227S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001033
ER
PT J
AU Cadet, JL
AF Cadet, Jean Lud
TI Chronic Methamphetamine Exposure Induces Large Scale Transcriptional
Alterations and Epigenetic Modifications in the Rat Dorsal Striatum
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Cadet, Jean Lud] NIDA, NIH, Iintramural Res Program, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 709
BP 227S
EP 227S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001034
ER
PT J
AU Brotman, MA
AF Brotman, Melissa A.
TI Neural Correlated of Face Emotion Processing and Cognitive Flexibility
in Youth At Risk for Bipolar Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE bipolar disorder; at risk; face emotion; attention; fMRI
C1 [Brotman, Melissa A.] NIMH, Bethesda, MD 20892 USA.
RI Brotman, Melissa/H-7409-2013
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 734
BP 233S
EP 233S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001053
ER
PT J
AU Martinowich, K
AF Martinowich, Keri
TI Promoter-Specific Bdnf Transcription in Sleep-Related Plasticity
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Martinowich, Keri] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 750
BP 237S
EP 237S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001069
ER
PT J
AU Greenstein, D
AF Greenstein, Deanna
TI Using Structural MRI to Explore Psychosis as a Dimension
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
C1 [Greenstein, Deanna] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 760
BP 240S
EP 240S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001079
ER
PT J
AU Alexander-Bloch, A
Raznahan, A
Lalonde, F
Clasen, L
Bullmore, ET
Giedd, J
AF Alexander-Bloch, Aaron
Raznahan, Armin
Lalonde, Francois
Clasen, Liv
Bullmore, Edward T.
Giedd, Jay
TI 6 Minutes of fMRI, 12 Years of Correlated Growth: A Comparison of
Functional and Structural Large-Scale Brain Networks
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE graph theory; development; functional connectivity; cortical thickness;
brain networks
C1 [Alexander-Bloch, Aaron; Raznahan, Armin; Lalonde, Francois; Clasen, Liv; Giedd, Jay] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[Alexander-Bloch, Aaron; Bullmore, Edward T.] Univ Cambridge, Cambridge, England.
RI Raznahan, Armin/F-4534-2012; Giedd, Jay/B-7302-2012; Giedd,
Jay/J-9644-2015; Bullmore, Edward/C-1706-2012
OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978;
Bullmore, Edward/0000-0002-8955-8283
NR 0
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 763
BP 241S
EP 241S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001082
ER
PT J
AU Callicott, JH
Zhang, FY
Straub, RE
Mattay, VS
Weinberger, DR
AF Callicott, Joseph H.
Zhang, Fengyu
Straub, Richard E.
Mattay, Venkata S.
Weinberger, Daniel R.
TI Hippocampal Activation And Connectivity Effects Of A Genome-wide
Schizophrenia Candidates Variant In Prr16
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE fMRI; genetics; schizophrenia; hippocampus; genome-wide
C1 [Callicott, Joseph H.; Zhang, Fengyu; Mattay, Venkata S.] NIMH, DIRP, NIH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Straub, Richard E.; Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 802
BP 253S
EP 253S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001115
ER
PT J
AU Moran, ME
Greenstein, DK
Malley, JD
Weisinger, BM
Dasgupta, A
Gogtay, N
Rapoport, JL
AF Moran, Marcel E.
Greenstein, Deanna K.
Malley, James D.
Weisinger, Brian M.
Dasgupta, Abhijit
Gogtay, Nitin
Rapoport, Judith L.
TI Applying Multivariate Methods to Structural MRI Data using Childhood
Onset Schizophrenia and Control Samples
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE MRI; Schizophrenia; Multivariate
C1 [Moran, Marcel E.; Greenstein, Deanna K.; Weisinger, Brian M.; Gogtay, Nitin; Rapoport, Judith L.] NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA.
[Malley, James D.] NIH, Ctr Informat Technol, Bethesda, MD 20892 USA.
[Dasgupta, Abhijit] NIAMS, Clin Trials & Outcomes Branch, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 820
BP 259S
EP 259S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001133
ER
PT J
AU Cropp, B
Jabbi, M
Kohn, P
Baller, E
Kippenhan, JS
Eisenberg, D
Masdeu, J
Berman, KF
AF Cropp, Brett
Jabbi, Mbemba
Kohn, Philip
Baller, Erica
Kippenhan, Jonathan S.
Eisenberg, Daniel
Masdeu, Joseph
Berman, Karen F.
TI Midbrain Presynaptic Dopamine Mediates Instrumental Choice Behavior
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Dopamine; Motivation; Midbrain; Decision Making; Instrumental Learning
C1 [Cropp, Brett; Jabbi, Mbemba; Kohn, Philip; Baller, Erica; Kippenhan, Jonathan S.; Eisenberg, Daniel; Masdeu, Joseph; Berman, Karen F.] NIMH, Clin Brain Disorders Branch, Sect Integrated Neuroimaging, Bethesda, MD 20892 USA.
RI Eisenberg, Daniel/C-7432-2014; Eisenberg, Daniel/S-4342-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 827
BP 262S
EP 262S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001140
ER
PT J
AU Johnson, SL
Greenstein, DK
Lalonde, F
Gogtay, N
AF Johnson, Sarah L.
Greenstein, Deanna K.
Lalonde, Francois
Gogtay, Nitin
TI Corpus Callosal Volume in Childhood Onset Schizophrenia Patients,
Healthy Siblings and Normal Volunteers
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE MRI; Schizophrenia; Corpus Callosum
C1 [Johnson, Sarah L.; Greenstein, Deanna K.; Lalonde, Francois; Gogtay, Nitin] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 828
BP 262S
EP 262S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001141
ER
PT J
AU Vyas, NS
Rubinstein, DY
Carver, FW
Mattai, AA
Stidd, R
Holroyd, T
Weisinger, BM
David, CN
Turner, C
Clasen, L
Miller, R
Tossell, JW
Coppola, R
Rapoport, JL
Gogtay, N
AF Vyas, Nora S.
Rubinstein, Daniel Y.
Carver, Frederick W.
Mattai, Anand A.
Stidd, Reva
Holroyd, Tom
Weisinger, Brian M.
David, Christopher N.
Turner, Cheryl
Clasen, Liv
Miller, Rachel
Tossell, Julia W.
Coppola, Richard
Rapoport, Judith L.
Gogtay, Nitin
TI Alterations in Magnetoencephalographic Gamma Oscillatory Patterns During
Resting-State in Patients with Childhood-Onset Schizophrenia,
Non-Psychotic Siblings and Healthy Controls
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE adolescent; schizophrenia; default network; MEG; synchrony
C1 [Vyas, Nora S.; Mattai, Anand A.; Stidd, Reva; Weisinger, Brian M.; David, Christopher N.; Turner, Cheryl; Clasen, Liv; Miller, Rachel; Tossell, Julia W.; Rapoport, Judith L.; Gogtay, Nitin] NIH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[Rubinstein, Daniel Y.; Carver, Frederick W.; Holroyd, Tom; Coppola, Richard] NIH, MEG Core Facil, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 829
BP 262S
EP 263S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001142
ER
PT J
AU Kaplan, CM
Molina, JL
Chen, Q
Weinberger, DR
Tan, HY
AF Kaplan, Claire M.
Molina, Juan L.
Chen, Qiang
Weinberger, Daniel R.
Tan, Hao Yang
TI Anterior and Dorsolateral Prefrontal Effective Connectivity Deficits in
Evaluating and Updating Contextual Information in Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Schizophrenia; fMRI; Connectivity; Prefrontal; Decision
C1 [Kaplan, Claire M.; Molina, Juan L.; Chen, Qiang; Weinberger, Daniel R.; Tan, Hao Yang] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 831
BP 263S
EP 263S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001144
ER
PT J
AU Weisinger, B
Greenstein, D
Clasen, L
Lalonde, F
Miller, R
Gochman, P
Rapoport, JL
Gogtay, N
AF Weisinger, Brian
Greenstein, Deanna
Clasen, Liv
Lalonde, Francois
Miller, Rachel
Gochman, Peter
Rapoport, Judith L.
Gogtay, Nitin
TI Cortical Brain Development in Schizophrenia Spectrum Diagnosed Siblings
of Patients with Childhood-Onset Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE schizophrenia; childhood-onset; siblings; spectrum; adolescents
C1 [Weisinger, Brian; Greenstein, Deanna; Clasen, Liv; Lalonde, Francois; Miller, Rachel; Gochman, Peter; Rapoport, Judith L.; Gogtay, Nitin] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 830
BP 263S
EP 263S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001143
ER
PT J
AU Xu, K
Seo, D
Hodgkinson, C
Goldman, D
Sinha, R
AF Xu, Ke
Seo, Dongju
Hodgkinson, Colin
Goldman, David
Sinha, Rajita
TI A Regulatory Variant in OPRK1 Modulated Hypothalamic and Limbic Brain
Activity in Response to Stress and Predicts Relapse in Cocaine
Dependence in African Americans
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE OPRK1; Brain activity; relapse; Cocaine dependence; African Americans
C1 [Xu, Ke] Yale Univ, West Haven, CT USA.
[Seo, Dongju; Sinha, Rajita] Yale Univ, Stress Ctr, New Haven, CT USA.
[Hodgkinson, Colin; Goldman, David] NIAAA, Intramural Program, Rockville, MD 20852 USA.
RI Seo, Dongju/F-2988-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 869
BP 275S
EP 275S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001182
ER
PT J
AU Kawa, AB
Hope, BT
Harvey, BK
Shaham, Y
Calu, DJ
AF Kawa, Alex B.
Hope, Bruce T.
Harvey, Brandon K.
Shaham, Yavin
Calu, Donna J.
TI Effect of Optical Inhibition of Dorsal Medial Prefrontal Cortex
Pyramidal Neurons on Yohimbine- and Pellet-Priming-Induced Reinstatement
of Food Seeking in Female Rats
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE optogenetics; reinstatement; feeding; dorsal medial prefrontal cortex;
stress
C1 [Kawa, Alex B.; Hope, Bruce T.; Harvey, Brandon K.; Shaham, Yavin; Calu, Donna J.] NIDA, Baltimore, MD USA.
RI Hope, Bruce/A-9223-2010
OI Hope, Bruce/0000-0001-5804-7061
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 897
BP 284S
EP 284S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001210
ER
PT J
AU Trampush, JW
Weinberger, D
Dickinson, D
AF Trampush, Joey W.
Weinberger, Daniel
Dickinson, Dwight
TI Scales for Investigation of Normal and Pathological Personality Traits
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE personality; schizophrenia; negative affect; positive affect;
psychopathology
C1 [Trampush, Joey W.; Weinberger, Daniel; Dickinson, Dwight] NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 904
BP 286S
EP 286S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001217
ER
PT J
AU Fanous, S
Guez-Barber, D
Goldart, EM
Schrama, R
Theberge, F
Bossert, JM
Van Seters, S
Shoham, Y
Hope, BT
AF Fanous, Sanya
Guez-Barber, Danielle
Goldart, Evan M.
Schrama, Regina
Theberge, Florence
Bossert, Jennifer M.
Van Seters, Sebastiaan
Shoham, Yavin
Hope, Bruce T.
TI Characterization of Prefrontal Cortex Neuronal Ensembles in Cue-induced
Heroin Seeking Using Facs and Neural Inactivation
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE self-administration; flow cytometry; opiate; neuronal ensemble; relapse
C1 [Fanous, Sanya; Guez-Barber, Danielle; Goldart, Evan M.; Schrama, Regina; Theberge, Florence; Bossert, Jennifer M.; Van Seters, Sebastiaan; Shoham, Yavin; Hope, Bruce T.] NIDA, Baltimore, MD USA.
[Guez-Barber, Danielle] Yale Univ, New Haven, CT USA.
RI Hope, Bruce/A-9223-2010
OI Hope, Bruce/0000-0001-5804-7061
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 909
BP 287S
EP 288S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001222
ER
PT J
AU Gorelick, DA
AF Gorelick, David A.
TI fMRI-Guided Transcranial Magnetic Stimulation (TMS) to Reduce
Cue-Induced Nicotine Craving
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE transcranial magnetic stimulation; fMRI; cue-induced; craving; nicotine
C1 [Gorelick, David A.] NIDA, IRP, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 911
BP 288S
EP 288S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001224
ER
PT J
AU Robinson, OJ
Allen, P
Overstreet, C
Pine, DS
Grillon, C
AF Robinson, Oliver J.
Allen, Phillip
Overstreet, Cassie
Pine, Daniel S.
Grillon, Christian
TI Acute Tryptophan Depletion Increases Translational Indices of Anxiety
but Not Fear: Implications for Mood and Anxiety Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Serotonin; anxiety; startle responses; CRH; BNST
C1 [Robinson, Oliver J.; Allen, Phillip; Overstreet, Cassie; Pine, Daniel S.; Grillon, Christian] NIMH, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 913
BP 289S
EP 289S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001226
ER
PT J
AU Marquardt, CA
Ibrahim, L
Luckenbaugh, DA
Zarate, CA
AF Marquardt, Craig A.
Ibrahim, Lobna
Luckenbaugh, David A.
Zarate, Carlos A.
TI Family History of Alcohol Dependence and Initial Antidepressant Response
to an N-methyl-D-aspartate Antagonist in Bipolar Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Ketamine; Bipolar disorder; Alcohol dependence; Family history;
Anitdepressant response
C1 [Marquardt, Craig A.; Ibrahim, Lobna; Luckenbaugh, David A.; Zarate, Carlos A.] NIMH, ETPB, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 924
BP 292S
EP 292S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001237
ER
PT J
AU Selter, JH
Duncan, WC
Sarasso, S
Zarate, CA
AF Selter, Jessica H.
Duncan, Wallace C.
Sarasso, Simone
Zarate, Carlos A.
TI Delta Sleep Ratio Predicts Ketamine Response in Major Depressive
Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Ketamine; Mood Disorder; Delta Sleep
C1 [Selter, Jessica H.; Duncan, Wallace C.; Zarate, Carlos A.] NIMH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 USA.
[Sarasso, Simone] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 925
BP 292S
EP 292S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001238
ER
PT J
AU Furey, M
Drevets, W
Khanna, A
Zarate, C
AF Furey, Maura
Drevets, Wayne
Khanna, Ashish
Zarate, Carlos
TI Differences in Response to Implicit Emotional Faces in Anterior
Cingulate Cortex Predict Antidepressant Response to Scopolamine in Major
Depressive Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE biomarker of response; antimuscarinic; neuroimaging; cognitive
neuroscience; emotion processing bias
C1 [Furey, Maura; Zarate, Carlos] NIMH, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
[Drevets, Wayne] Univ Oklahoma, Coll Med, Dept Psychiat, Laureate Inst Brain Res, Norman, OK 73019 USA.
[Khanna, Ashish] Amer Univ Caribbean, Sch Med, Coral Gables, FL USA.
RI Furey, Maura/H-5273-2013
NR 0
TC 1
Z9 1
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 928
BP 293S
EP 293S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001241
ER
PT J
AU Szczepanik, J
Drevets, W
Khanna, A
Zarate, C
Furey, M
AF Szczepanik, Joanna
Drevets, Wayne
Khanna, Ashish
Zarate, Carlos
Furey, Maura
TI Amygdala Response to Implicit and Explicit Sad Face Stimuli at Baseline
Predicts Antidepressant Treatment Response to Scopolamine in Major
Depressive Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Cognitive Neuroscience; Emotion; Fmri; Biomarkers; Antimuscarinic
C1 [Szczepanik, Joanna; Zarate, Carlos; Furey, Maura] NIMH, Bethesda, MD 20892 USA.
[Szczepanik, Joanna] Univ Maryland, College Pk, MD 20742 USA.
[Drevets, Wayne] Laureate Inst Brain Res, Tulsa, OK USA.
[Khanna, Ashish] Amer Univ Caribbean, Sch Med, Coral Gables, FL USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 927
BP 293S
EP 293S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001240
ER
PT J
AU Theberge, F
Kambhampati, S
Eichenbaum, H
Pickens, C
Rice, K
Shaham, Y
AF Theberge, Florence
Kambhampati, Santa
Eichenbaum, Hila
Pickens, Charles
Rice, Kenner
Shaham, Yavin
TI Effects of the Preferential Mu Opioid Receptor Antagonist(-)- Naloxone
and the Toll-like Receptor 4 Antagonist (+)- Naloxone on Heroin
Self-Administration and Incubation of Heroin Craving
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Heroin; self-administration; relapse; naloxone; toll-like receptor
C1 [Theberge, Florence; Kambhampati, Santa; Eichenbaum, Hila; Pickens, Charles; Rice, Kenner; Shaham, Yavin] NIDA, NIH, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 962
BP 303S
EP 304S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001274
ER
PT J
AU Fitzgerald, PJ
Whittle, N
Flynn, SM
Singewald, N
Holmes, A
AF Fitzgerald, Paul J.
Whittle, Nigel
Flynn, Shaun M.
Singewald, Nicolas
Holmes, Andrew
TI Fluoxetine Modulates Infralimbic Neuronal Extinction-Encoding in a Mouse
Model of Persistent Fear
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE fluoxetine; fear conditioning; neuropharmacology; inbred mouse strain;
ptsd
C1 [Fitzgerald, Paul J.; Flynn, Shaun M.; Holmes, Andrew] NIH, Lab Behav & Genom Neurosci, Rockville, MD USA.
[Whittle, Nigel; Singewald, Nicolas] Univ Innsbruck, Dept Pharmacol & Toxicol, A-6020 Innsbruck, Austria.
NR 0
TC 0
Z9 0
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 976
BP 307S
EP 307S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001287
ER
PT J
AU Jarcho, JM
Fox, NA
Pine, DS
Leibenluft, E
Shechner, T
Ernst, M
AF Jarcho, Johanna M.
Fox, Nathan A.
Pine, Daniel S.
Leibenluft, Ellen
Shechner, Tomer
Ernst, Monique
TI Neural Response to Emotional Conflict and Conflict Resolution is Altered
Among Young Adults Characterized as Behaviorally Inhibited During Early
Childhood
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Behavioral Inhibition; Conflict Adaptation; Emotional Conflict; fMRI
C1 [Jarcho, Johanna M.; Pine, Daniel S.; Shechner, Tomer; Ernst, Monique] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
[Fox, Nathan A.] Univ Maryland, Inst Child Study, Dept Human Dev, College Pk, MD 20742 USA.
[Leibenluft, Ellen] NIMH, Sect Bipolar Spectrum Disorders, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 975
BP 307S
EP 307S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001286
ER
PT J
AU Cho, YT
Ernst, M
Fudge, JL
AF Cho, Youngsun T.
Ernst, Monique
Fudge, Julie L.
TI The Functional Stations of the Amygdala, Based on
Cortico-Amygdala-Striatal Circuits
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Amygdala; Prefrontal Cortex; Striatum; Insula; Circuits
C1 [Cho, Youngsun T.; Fudge, Julie L.] Univ Rochester, Sch Med & Dent, Rochester, NY USA.
[Ernst, Monique] NIMH, Sect Dev & Affect Neurosci, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 978
BP 308S
EP 308S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001289
ER
PT J
AU Molina, JL
Kaplan, CM
Chen, Q
Weinberger, DR
Tan, HY
AF Molina, Juan L.
Kaplan, Claire M.
Chen, Qiang
Weinberger, Daniel R.
Tan, Hao Yang
TI Specific Cortical-Striatal Connectivity Deficits in Working Memory
Encoding in Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE Effective connectivity; Dynamic causal modeling; Schizophrenia;
Executive function
C1 [Molina, Juan L.; Kaplan, Claire M.; Chen, Qiang; Weinberger, Daniel R.; Tan, Hao Yang] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Weinberger, Daniel R.] Johns Hopkins Univ, Leiber Inst Brain Dev, Med Ctr, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 996
BP 313S
EP 313S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001307
ER
PT J
AU Tan, HY
Chen, AG
Kolachana, B
Apud, JA
Mattay, VS
Callicott, JH
Chen, Q
Weinberger, DR
AF Tan, Hao Yang
Chen, Anthony G.
Kolachana, Bhaskar
Apud, Jose A.
Mattay, Venkata S.
Callicott, Joseph H.
Chen, Qiang
Weinberger, Daniel R.
TI Effective Connectivity of Akt1-Mediated Dopaminergic Working Memory
Networks and the Pharmacogenetics of Antidopaminergic Treatment
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 67th Annual Scientific Convention and Meeting of the
Society-of-Biological-Psychiatry
CY MAY 03-05, 2012
CL Philadelphia, PA
SP Soc Biol Psychiat
DE COMT; DRD2; antipsychotics; fMRI; IQ
C1 [Tan, Hao Yang; Chen, Anthony G.; Kolachana, Bhaskar; Apud, Jose A.; Mattay, Venkata S.; Callicott, Joseph H.; Chen, Qiang; Weinberger, Daniel R.] NIH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA.
[Chen, Qiang; Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 15
PY 2012
VL 71
IS 8
SU S
MA 997
BP 314S
EP 314S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 921GL
UT WOS:000302466001308
ER
PT J
AU Rajan, A
Carter, CA
Kelly, RJ
Gutierrez, M
Kummar, S
Szabo, E
Yancey, MA
Ji, JP
Mannargudi, B
Woo, S
Spencer, S
Figg, WD
Giaccone, G
AF Rajan, Arun
Carter, Corey A.
Kelly, Ronan J.
Gutierrez, Martin
Kummar, Shivaani
Szabo, Eva
Yancey, Mary Ann
Ji, Jiuping
Mannargudi, Baskar
Woo, Sukyung
Spencer, Shawn
Figg, William Douglas
Giaccone, Giuseppe
TI A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine
in Adults with Solid Tumors
SO CLINICAL CANCER RESEARCH
LA English
DT Article
ID RIBOSE POLYMERASE INHIBITOR; POLY(ADP-RIBOSE) POLYMERASE-1; REPAIR;
CANCER; CELLS; TEMOZOLOMIDE; DEFICIENT; THERAPY; PATHWAY
AB Purpose: To determine the safety and tolerability of olaparib with cisplatin and gemcitabine, establish the maximum tolerated dose (MTD), and evaluate the pharmacodynamic and pharmacokinetic profile of the combination.
Experimental Design: We conducted a phase I study of olaparib with cisplatin and gemcitabine in patients with advanced solid tumors. Treatment at dose level 1 (DL1) consisted of olaparib 100 mg orally every 12 hours on days 1 to 4, gemcitabine 500 mg/m(2) on days 3 and 10, and cisplatin 60 mg/m(2) on day 3. PAR levels were measured in peripheral blood mononuclear cells (PBMC).
Results: Dose-limiting toxicities (DLT) in two of three patients at DL1 included thrombocytopenia and febrile neutropenia. The protocol was amended to enroll patients treated with <= 2 prior severely myelo-suppressive chemotherapy regimens and treated with olaparib 100 mg once daily on days 1 to 4 (DL-1). No DLTs were seen in six patients at DL-1. Because of persistent thrombocytopenia and neutropenia following a return to DL1, patients received 100 mg olaparib every 12 hours on day 1 only. No hematologic DLTs were observed; nonhematologic DLTs included gastrointestinal bleed, syncope, and hypoxia. Of 21 patients evaluable for response, two had partial response. Olaparib inhibited PARP in PBMCs and tumor tissue, although PAR levels were less effectively inhibited when olaparib was used for a short duration.
Conclusions: Olaparib in combination with cisplatin and gemcitabine is associated with myelosuppression even at relatively low doses. Modified schedules of olaparib in chemotherapy naive patients will have to be explored with standard doses of chemotherapy. Clin Cancer Res; 18(8); 2344-51. (C) 2012 AACR.
C1 [Rajan, Arun; Carter, Corey A.; Kelly, Ronan J.; Gutierrez, Martin; Kummar, Shivaani; Szabo, Eva; Yancey, Mary Ann; Ji, Jiuping; Mannargudi, Baskar; Woo, Sukyung; Figg, William Douglas; Giaccone, Giuseppe] NCI, Med Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Spencer, Shawn] NCI, Clin Pharmacol Program, SAIC Frederick Inc, Ctr Canc Res, Frederick, MD USA.
RP Giaccone, G (reprint author), NCI, Med Oncol Branch, Ctr Canc Res, NIH, 10 Ctr Dr,Room 12N226, Bethesda, MD 20892 USA.
EM giacconeg@mail.nih.gov
RI Figg Sr, William/M-2411-2016; Giaccone, Giuseppe/E-8297-2017;
OI Giaccone, Giuseppe/0000-0002-5023-7562; Mannargudi,
Baskar/0000-0001-6430-0641
FU National Cancer Institute, NIH; AstraZeneca; Center for Cancer Research,
National Cancer Institute, NIH
FX This project has been funded in whole or in part with federal funds from
the National Cancer Institute, NIH. This work was supported by
AstraZeneca and the Intramural Research Program of the Center for Cancer
Research, National Cancer Institute, NIH.
NR 23
TC 63
Z9 65
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD APR 15
PY 2012
VL 18
IS 8
BP 2344
EP 2351
DI 10.1158/1078-0432.CCR-11-2425
PG 8
WC Oncology
SC Oncology
GA 927KW
UT WOS:000302907300026
PM 22371451
ER
PT J
AU Stein, WD
Wilkerson, J
Kim, ST
Huang, X
Motzer, RJ
Fojo, AT
Bates, SE
AF Stein, Wilfred D.
Wilkerson, Julia
Kim, Sindy T.
Huang, Xin
Motzer, Robert J.
Fojo, Antonio Tito
Bates, Susan E.
TI Analyzing the Pivotal Trial That Compared Sunitinib and IFN-alpha in
Renal Cell Carcinoma, Using a Method That Assesses Tumor Regression and
Growth
SO CLINICAL CANCER RESEARCH
LA English
DT Article
ID PHASE-III TRIAL; INTERFERON-ALPHA; CLINICAL-TRIAL; RATE CONSTANTS;
DOUBLE-BLIND; SURVIVAL; BEVACIZUMAB
AB Purpose: We applied a method that analyzes tumor response, quantifying the rates of tumor growth (g) and regression (d), using tumor measurements obtained while patients receive therapy. We used data from the phase III trial comparing sunitinib and IFN-alpha in metastatic renal cell carcinoma (mRCC) patients.
Methods: The analysis used an equation that extracts d and g.
Results: For sunitinib, overall survival (OS) was strongly correlated with log g (Rsq = 0.44, P < 0.0001); much less with log d (Rsq = 0.04; P = 0.0002). The median g of tumors in these patients (0.00082 per days; log g = 3.09) was about half that (P < 0.001) of tumors in patients receiving IFN-alpha (0.0015 per day; log g = = 2.81). With IFN-alpha, the OS/log g correlation (Rsq = 0.14) was weaker. Values of g from measurements obtained by study investigators or central review were highly correlated (Rsq = 0.80). No advantage resulted in including data from central review in regressions. Furthermore, g can be estimated accurately four months before treatment discontinuation. Extrapolating g in a model that incorporates survival generates the hypothesis that g increased after discontinuation of sunitinib but did not accelerate.
Conclusions: In patients with mRCC, sunitinib reduced tumor growth rate, g, more than did IFN-alpha. Correlating g with OS confirms earlier analyses suggesting g may be an important clinical trial endpoint, to be explored prospectively and in individual patients. Clin Cancer Res; 18(8); 2374-81. (C) 2012 AACR.
C1 [Stein, Wilfred D.; Wilkerson, Julia; Fojo, Antonio Tito; Bates, Susan E.] NCI, Med Oncol Branch, NIH, Bethesda, MD 20892 USA.
[Stein, Wilfred D.] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Jerusalem, Israel.
[Kim, Sindy T.; Huang, Xin] Pfizer Inc, La Jolla, CA USA.
[Motzer, Robert J.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
RP Bates, SE (reprint author), NCI, Med Oncol Branch, NIH, Bldg 10,RM 12N226,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM sebates@helix.nih.gov
FU NIH; Pfizer
FX This work was supported by NIH Intramural Research Program.; S.T. Kim:
stock, Pfizer. R.J. Motzer received commercial research support and is a
consultant on the advisory board of Pfizer. No other potential conflicts
of interest were disclosed by the other authors.
NR 21
TC 27
Z9 28
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD APR 15
PY 2012
VL 18
IS 8
BP 2374
EP 2381
DI 10.1158/1078-0432.CCR-11-2275
PG 8
WC Oncology
SC Oncology
GA 927KW
UT WOS:000302907300029
PM 22344231
ER
PT J
AU Jovic, M
Kean, MJ
Szentpetery, Z
Polevoy, G
Gingras, AC
Brill, JA
Balla, T
AF Jovic, Marko
Kean, Michelle J.
Szentpetery, Zsofia
Polevoy, Gordon
Gingras, Anne-Claude
Brill, Julie A.
Balla, Tamas
TI Two phosphatidylinositol 4-kinases control lysosomal delivery of the
Gaucher disease enzyme, beta-glucocerebrosidase
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Article
ID OXYSTEROL-BINDING-PROTEIN; GOLGI-COMPLEX; PLASMA-MEMBRANE; LIMP-II;
SACCHAROMYCES-CEREVISIAE; INTRACELLULAR-TRANSPORT;
ENDOPLASMIC-RETICULUM; MASS-SPECTROMETRY; CYTOPLASMIC TAIL; CONTACT
SITES
AB Gaucher disease is a lysosomal storage disorder caused by a defect in the degradation of glucosylceramide catalyzed by the lysosomal enzyme beta-glucocerebrosidase (GBA). GBA reaches lysosomes via association with its receptor, lysosomal integral membrane protein type 2 (LIMP-2). We found that distinct phosphatidylinositol 4-kinases (PI4Ks) play important roles at multiple steps in the trafficking pathway of the LIMP-2/GBA complex. Acute depletion of phosphatidylinositol 4-phosphate in the Golgi caused accumulation of LIMP-2 in this compartment, and PI4KIII beta was found to be responsible for controlling the exit of LIMP-2 from the Golgi. In contrast, depletion of PI4KII alpha blocked trafficking at a post-Golgi compartment, leading to accumulation of LIMP-2 in enlarged endosomal vesicles. PI4KII alpha depletion also caused secretion of missorted GBA into the medium, which was attenuated by limiting LIMP-2/GBA exit from the Golgi by PI4KIII beta inhibitors. These studies identified PI4KIII beta and PI4KII alpha as important regulators of lysosomal delivery of GBA, revealing a new element of control to sphingolipid homeostasis by phosphoinositides.
C1 [Jovic, Marko; Szentpetery, Zsofia; Balla, Tamas] NICHHD, Sect Mol Signal Transduct, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA.
[Kean, Michelle J.; Gingras, Anne-Claude] Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Kean, Michelle J.; Gingras, Anne-Claude; Brill, Julie A.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.
[Polevoy, Gordon; Brill, Julie A.] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1L7, Canada.
RP Balla, T (reprint author), NICHHD, Sect Mol Signal Transduct, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA.
EM ballat@mail.nih.gov
RI Gingras, Anne-Claude/E-9982-2010;
OI Gingras, Anne-Claude/0000-0002-6090-4437; Balla,
Tamas/0000-0002-9077-3335
FU Eunice Kennedy Shriver NICHD, NIH; Canadian Institutes of Health
Research (CIHR) [MOP-84314, CIHR MOP-102546]
FX Confocal imaging was performed at the Microscopy and Imaging Core of the
NICHD, NIH, with the kind assistance of Vincent Schram and James T.
Russell. We thank Jason Burgess for reading the manuscript. This
research was supported in part by the Intramural Research Program of the
Eunice Kennedy Shriver NICHD, NIH. Work in the Gingras and Brill
laboratories was supported by the Canadian Institutes of Health Research
(CIHR MOP-84314 to A.-C.G. and CIHR MOP-102546 to J.A.B.). A.-C.G. holds
the Lea Reichmann Chair in Cancer Proteomics and a Canada Research Chair
in Functional Proteomics. M.J.K. is supported by CIHR through a Banting
and Best Canada Graduate Scholarship.
NR 65
TC 39
Z9 39
U1 0
U2 5
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PD APR 15
PY 2012
VL 23
IS 8
BP 1533
EP 1545
DI 10.1091/mbc.E11-06-0553
PG 13
WC Cell Biology
SC Cell Biology
GA 930BX
UT WOS:000303111900014
PM 22337770
ER
PT J
AU Lin, S
Yang, JH
Elkahloun, AG
Bandyopadhyay, A
Wang, L
Cornell, JE
Yeh, IT
Agyin, J
Tomlinson, G
Sun, LZ
AF Lin, Shu
Yang, Junhua
Elkahloun, Abdel G.
Bandyopadhyay, Abhik
Wang, Long
Cornell, John E.
Yeh, I-Tien
Agyin, Joseph
Tomlinson, Gail
Sun, Lu-Zhe
TI Attenuation of TGF-beta signaling suppresses premature senescence in a
p21-dependent manner and promotes oncogenic Ras-mediated metastatic
transformation in human mammary epithelial cells
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Article
ID GROWTH-FACTOR-BETA; CANCER MDA-MB-231 CELLS; BREAST-CANCER;
GENE-EXPRESSION; C-MYC; II RECEPTOR; INHIBITION; KERATINOCYTES;
TUMORIGENESIS; CARCINOMA
AB The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusive. Few molecular targets have been identified for the prevention or treatment of this disease. Here we developed a series of isogenic basal-like human mammary epithelial cells (HMECs) with altered transforming growth factor-beta (TGF-beta) sensitivity and different malignancy, resembling a full spectrum of basal-like breast carcinogenesis, and determined the molecular mechanisms that contribute to oncogene-induced transformation of basal-like HMECs when TGF-beta signaling is attenuated. We found that expression of a dominant-negative type II receptor (DNRII) of TGF-beta abrogated autocrine TGF-beta signaling in telomerase-immortalized HMECs and suppressed H-Ras-V12-induced senescence-like growth arrest (SLGA). Furthermore, coexpression of DNRII and H-Ras-V12 rendered HMECs highly tumorigenic and metastatic in vivo in comparison with H-Ras-V12-transformed HMECs that spontaneously escaped H-Ras-V12-induced SLGA. Microarray analysis revealed that p21 was the major player mediating Ras-induced SLGA, and attenuated or loss of p21 expression contributed to the escape from SLGA when autocrine TGF-beta signaling was blocked in HMECs. Furthermore, knockdown of p21 also suppressed H-Ras-V12-induced SLGA. Our results identify that autocrine TGF-beta signaling is an integral part of the cellular anti-transformation network by suppressing the expression of a host of genes, including p21-regulated genes, that mediate oncogene-induced transformation in basal-like breast cancer.
C1 [Lin, Shu; Yang, Junhua; Bandyopadhyay, Abhik; Wang, Long; Agyin, Joseph; Sun, Lu-Zhe] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
[Elkahloun, Abdel G.] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
[Cornell, John E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA.
[Yeh, I-Tien] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA.
[Tomlinson, Gail] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA.
[Sun, Lu-Zhe] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA.
RP Sun, LZ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
EM sunl@uthscsa.edu
RI Lin, Shu/C-3790-2013
FU National Institutes of Health [R01CA75253, R01CA79683]; Cancer Therapy
and Research Center at the University of Texas Health Science Center at
San Antonio (UTHSCSA) through National Cancer Institute Cancer Center [2
P30 CA054174-17]
FX This work was supported in part by National Institutes of Health Grants
R01CA75253 and R01CA79683 and the Cancer Therapy and Research Center at
the University of Texas Health Science Center at San Antonio (UTHSCSA)
through National Cancer Institute Cancer Center Support Grant 2 P30
CA054174-17. We thank Andrew Hinck (UTHSCSA) for the recombinant
TGF-beta 3, Peter J. Hornsby (UTHSCSA) for the H-Ras-V12 expression
plasmid, Xinhua Feng (Baylor College of Medicine, Houston, TX) for the
p21 promoter-Luc report plasmid, Gokul Das (Roswell Park Cancer
Institute, Buffalo, NY) for the PCNA promoter-Luc report plasmid, and
Bert Vogelstein (Johns Hopkins Medical School) for the pSBE4-Luc
plasmid. We also thank James Jackson (MD Anderson Cancer Center,
Houston, TX) for technical assistance with the chromatin
immunoprecipitation assay.
NR 64
TC 21
Z9 21
U1 0
U2 6
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PD APR 15
PY 2012
VL 23
IS 8
BP 1569
EP 1581
DI 10.1091/mbc.E11-10-0849
PG 13
WC Cell Biology
SC Cell Biology
GA 930BX
UT WOS:000303111900017
PM 22357622
ER
PT J
AU Stubblefield, MD
McNeely, ML
Alfano, CM
Mayer, DK
AF Stubblefield, Michael D.
McNeely, Margaret L.
Alfano, Catherine M.
Mayer, Deborah K.
TI A prospective surveillance model for physical rehabilitation of women
with breast cancer
SO CANCER
LA English
DT Article
DE cancer; rehabilitation; survivorship; neuropathy; chemotherapy;
radiculopathy; brachial plexopathy; breast cancer; surveillance; pain;
palliative care
ID INDUCED PERIPHERAL NEUROPATHY; PHASE-I TRIAL; CHARCOT-MARIE-TOOTH;
LONG-TERM-CARE; OVARIAN-CANCER; CHEMOTHERAPY; TAXOL; MANAGEMENT;
SURVIVORS; EXERCISE
AB Chemotherapy-induced peripheral neuropathy (CIPN) results from damage to or dysfunction of the peripheral nerves. The development of CIPN is anticipated for the majority of breast cancer patients who receive neurotoxic chemotherapy, depending on the agent used, dose, and schedule. Sensory symptoms often predominate and include numbness, tingling, and distal extremity pain. Weakness, gait impairment, loss of functional abilities, and other deficits may develop with more severe CIPN. This article outlines a prospective surveillance model for physical rehabilitation of women with breast cancer who develop CIPN. Rehabilitative efforts for CIPN start at the time of breast cancer diagnosis and treatment planning. The prechemotherapy evaluation identifies patients with preexisting peripheral nervous system disorders that may place them at higher risk for the development of CIPN. This clinical evaluation should include a history focusing on symptoms and functional activities as well as a physical examination that objectively assesses the patient's strength, sensation, reflexes, and gait. Ongoing surveillance following the initiation of a neurotoxic agent is important to monitor for the development and progression of symptoms associated with CIPN, and to ensure its resolution over the long term. CIPN is managed best by a multidisciplinary team approach. Early identification of symptoms will ensure appropriate referral and timely symptom management. The prospective surveillance model promotes a patient-centered approach to care, from pretreatment through survivorship and palliative care. In this way, the model offers promise in addressing and minimizing both the acute and long-term morbidity associated with CIPN. Cancer 2012;. (c) 2012 American Cancer Society.
C1 [Stubblefield, Michael D.] Mem Sloan Kettering Canc Ctr, Sillerman Ctr Rehabil, New York, NY 10022 USA.
[Stubblefield, Michael D.] Mem Sloan Kettering Canc Ctr, Dept Neurol, Rehabil Med Serv, New York, NY 10022 USA.
[Stubblefield, Michael D.] Cornell Univ, Weill Med Coll, Dept Phys Med & Rehabil, New York, NY 10021 USA.
[McNeely, Margaret L.] Univ Alberta, Dept Phys Therapy & Oncol, Edmonton, AB, Canada.
[McNeely, Margaret L.] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada.
[Alfano, Catherine M.] NCI, Off Canc Survivorship, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
[Mayer, Deborah K.] Univ N Carolina, Sch Nursing, Chapel Hill, NC USA.
RP Stubblefield, MD (reprint author), Mem Sloan Kettering Canc Ctr, Sillerman Ctr Rehabil, 515 Madison Ave,5th Floor, New York, NY 10022 USA.
EM stubblem@mskcc.org
FU American Cancer Society through The Longaberger Company(R); Longaberger
Horizon of Hope(R) Campaign
FX Support for this meeting and supplement were provided by the American
Cancer Society through The Longaberger Company (R), a direct selling
company offering home products including hand-crafted baskets made in
Ohio, and the Longaberger Horizon of Hope (R) Campaign, which provided a
grant to the American Cancer Society for breast cancer research and
education.
NR 63
TC 26
Z9 27
U1 1
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0008-543X
J9 CANCER-AM CANCER SOC
JI Cancer
PD APR 15
PY 2012
VL 118
SU 8
BP 2250
EP 2260
DI 10.1002/cncr.27463
PG 11
WC Oncology
SC Oncology
GA 922JV
UT WOS:000302544100008
PM 22488699
ER
PT J
AU Sharma, A
Chen, QH
Nguyen, T
Yu, Q
Sen, JM
AF Sharma, Archna
Chen, Qinghua
Trang Nguyen
Yu, Qing
Sen, Jyoti Misra
TI T Cell Factor-1 and beta-Catenin Control the Development of Memory-like
CD8 Thymocytes
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID DEFICIENT MICE; PATHWAY; TCF-1; DIFFERENTIATION; EXPRESSION; GENERATION;
SELECTION; LINEAGE
AB Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and beta-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and beta-catenin-dependent memory-like CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-gamma. Thus, TCF1 and beta-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus. The Journal of Immunology, 2012, 188: 3859-3868.
C1 [Sharma, Archna; Chen, Qinghua; Trang Nguyen; Yu, Qing; Sen, Jyoti Misra] NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA.
RP Sen, JM (reprint author), NIA, Lab Mol Biol & Immunol, NIH, 8C218 Biomed Res Ctr Bldg,251 Bayview Blvd, Baltimore, MD 21224 USA.
EM Jyoti-Sen@nih.gov
RI Sharma, Archna/R-9377-2016
OI Sharma, Archna/0000-0003-4745-0220
FU National Institute on Aging at the National Institutes of Health
FX This work was supported by the Intramural Research Program of the
National Institute on Aging at the National Institutes of Health.
NR 35
TC 17
Z9 17
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD APR 15
PY 2012
VL 188
IS 8
BP 3859
EP 3868
DI 10.4049/jimmunol.1103729
PG 10
WC Immunology
SC Immunology
GA 923TD
UT WOS:000302641400033
PM 22492686
ER
PT J
AU Ranguelova, K
Rice, AB
Khajo, A
Triquigneaux, M
Garantziotis, S
Magliozzo, RS
Mason, RP
AF Ranguelova, Kalina
Rice, Annette B.
Khajo, Abdelahad
Triquigneaux, Mathilde
Garantziotis, Stavros
Magliozzo, Richard S.
Mason, Ronald P.
TI Formation of reactive sulfite-derived free radicals by the activation of
human neutrophils: An ESR study
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Sulfite toxicity; Sulfite-derived radicals; ESR spectroscopy; DMPO;
Human neutrophils; Myeloperoxidase; Free radicals
ID HUMAN POLYMORPHONUCLEAR LEUKOCYTES; PEROXIDASE-CATALYZED OXIDATION;
MYELOPEROXIDASE COMPOUND-I; HORSERADISH-PEROXIDASE; HYDROGEN-PEROXIDE;
RAT HEPATOCYTES; ANTIINFLAMMATORY DRUGS; SULFUR-DIOXIDE; NADPH OXIDASE;
SO5-RADICALS
AB The objective of this study was to determine the effect of (bi)sulfite (hydrated sulfur dioxide) on human neutrophils and the ability of these immune cells to produce reactive free radicals due to (bi)sulfite oxidation. Myeloperoxidase (MPO) is an abundant heme protein in neutrophils that catalyzes the formation of cytotoxic oxidants implicated in asthma and inflammatory disorders. In this study sulfite ((SO3-)-S-center dot) and sulfate (SO4 center dot-) anion radicals are characterized with the ESR spin-trapping technique using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) in the reaction of (bi)sulfite oxidation by human MPO and human neutrophils via sulfite radical chain reaction chemistry. After treatment with (bi)sulfite, phorbol 12-myristate 13-acetate-stimulated neutrophils produced DMPO-sulfite anion radical, -superoxide, and -hydroxyl radical adducts. The last adduct probably resulted, in part, from the conversion of DMPO-sulfate to DMPO-hydroxyl radical adduct via a nucleophilic substitution reaction of the radical adduct. This anion radical (SO4 center dot-) is highly reactive and, presumably, can oxidize target proteins to protein radicals, thereby initiating protein oxidation. Therefore, we propose that the potential toxicity of (bi)sulfite during pulmonary inflammation or lung-associated diseases such as asthma may be related to free radical formation. Published by Elsevier Inc.
C1 [Ranguelova, Kalina; Triquigneaux, Mathilde; Mason, Ronald P.] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
[Rice, Annette B.; Garantziotis, Stavros] NIEHS, Clin Res Unit, NIH, Res Triangle Pk, NC 27709 USA.
[Khajo, Abdelahad; Magliozzo, Richard S.] CUNY Brooklyn Coll, Dept Chem, Brooklyn, NY 11210 USA.
[Khajo, Abdelahad; Magliozzo, Richard S.] CUNY, Grad Ctr, Dept Chem, New York, NY USA.
[Khajo, Abdelahad; Magliozzo, Richard S.] CUNY, Grad Ctr, Dept Biochem, New York, NY USA.
RP Mason, RP (reprint author), NIEHS, Lab Toxicol & Pharmacol, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM mason4@niehs.nih.gov
RI Garantziotis, Stavros/A-6903-2009
OI Garantziotis, Stavros/0000-0003-4007-375X
FU National Institute of Environmental Health Sciences, National Institutes
of Health
FX We acknowledge Mary J. Mason, Dr. Ann Motten, and Jean Corbett for their
editing of the manuscript. Also, we thank Ms. Brenda Yingling and Ms.
Jamie D. Marshburn for their technical assistance. This work has been
supported by the Intramural Research Program of the National Institute
of Environmental Health Sciences, National Institutes of Health.
NR 68
TC 28
Z9 29
U1 10
U2 44
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR 15
PY 2012
VL 52
IS 8
BP 1264
EP 1271
DI 10.1016/j.freeradbiomed.2012.01.016
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 920WQ
UT WOS:000302439900002
PM 22326772
ER
PT J
AU Horvath, B
Mukhopadhyay, P
Kechrid, M
Patel, V
Tanchian, G
Wink, DA
Gertsch, J
Pacher, P
AF Horvath, Bela
Mukhopadhyay, Partha
Kechrid, Malek
Patel, Vivek
Tanchian, Galin
Wink, David A.
Gertsch, Juerg
Pacher, Pal
TI beta-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a
cannabinoid 2 receptor-dependent manner
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Nephropathy; Cisplatin; (E)-beta-caryophyllene; Cannabinoid 2 receptor;
Inflammation; Oxidative stress; Cell death; Free radicals
ID HEPATIC ISCHEMIA/REPERFUSION INJURY; SODIUM-INDUCED COLITIS;
NITRIC-OXIDE; REACTIVE OXYGEN; ENDOCANNABINOID SYSTEM; OXIDATIVE STRESS;
CELL-DEATH; INDUCED CARDIOMYOPATHY; HUMAN CARDIOMYOCYTES; CB2 RECEPTORS
AB (E)-beta-caryophyllene (BCP) is a natural sesquiterpene found in many essential oils of spice (best known for contributing to the spiciness of black pepper) and food plants with recognized anti-inflammatory properties. Recently it was shown that BCP is a natural agonist of endogenous cannabinoid 2 (CB2) receptors, which are expressed in immune cells and mediate anti-inflammatory effects. In this study we aimed to test the effects of BCP in a clinically relevant murine model of nephropathy (induced by the widely used antineoplastic drug cisplatin) in which the tubular injury is largely dependent on inflammation and oxidative/nitrative stress. beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1 beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration). It also markedly mitigated oxidative/nitrative stress (NOX-2 and NOX-4 expression, 4-HNE and 3-NT content) and cell death. The protective effects of BCP against biochemical and histological markers of nephropathy were absent in CB2 knockout mice. Thus. BCP may be an excellent therapeutic agent to prevent cisplatin-induced nephrotoxicity through a CB2 receptor-dependent pathway. Given the excellent safety profile of BCP in humans it has tremendous therapeutic potential in a multitude of diseases associated with inflammation and oxidative stress. Published by Elsevier Inc.
C1 [Horvath, Bela; Mukhopadhyay, Partha; Kechrid, Malek; Patel, Vivek; Tanchian, Galin; Pacher, Pal] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA.
[Wink, David A.] NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA.
[Gertsch, Juerg] Univ Bern, Inst Biochem & Mol Med, CH-3012 Bern, Switzerland.
RP Pacher, P (reprint author), NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA.
EM pacher@mail.nih.gov
RI Pacher, Pal/B-6378-2008; MUKHOPADHYAY, PARTHA/G-3890-2010; Horvath,
Bela/A-7368-2009
OI Pacher, Pal/0000-0001-7036-8108; MUKHOPADHYAY,
PARTHA/0000-0002-1178-1274;
FU NIH/NIAAA; Hungarian Scientific Research Fund [OTKA-NKTH-EU MB08-80238];
[HL072889]
FX This study was supported by the Intramural Research Program of the
NIH/NIAAA (to P.P.) and HL072889 (to B.H.). Dr. Bela Horvath is the
recipient of a Hungarian Scientific Research Fund Fellowship
(OTKA-NKTH-EU MB08-80238). The authors are indebted to Dr. George Kunos
for continuous support. Dr. Pacher dedicates this study to his beloved
mother Iren Bolfert, who died from complications of chemotherapy.
NR 71
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U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR 15
PY 2012
VL 52
IS 8
BP 1325
EP 1333
DI 10.1016/j.freeradbiomed.2012.01.014
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 920WQ
UT WOS:000302439900008
PM 22326488
ER
PT J
AU Lin, BR
Natarajan, V
AF Lin, Bor-Ruei
Natarajan, Ven
TI Negative regulation of human U6 snRNA promoter by p38 kinase through
Oct-1
SO GENE
LA English
DT Article
DE U6 promoter; Oct-1; p38 kinase; SB202190; MAPK
ID ACTIVATED PROTEIN-KINASE; RNA POLYMERASE-III; SMALL NUCLEAR-RNA;
TRANSCRIPTION FACTOR OCT-1; DNA-BINDING ACTIVITY; MAP KINASE; POU
DOMAIN; CELL-SURVIVAL; OXIDATIVE STRESS; DOWN-REGULATION
AB Recruitment of Oct-1 protein to the octamer sequence of U6 promoter is critical for optimal transcription by RNA polymerase III. Here we report that p38 kinase inhibitors, SB202190 and SB203580, stimulated U6 promoter activity and this stimulation can be observed only in the presence of octamer sequence. SB202190-treated cell nuclear extract had about 50% increase in Oct-1 binding activity suggesting that the increased U6 promoter activity by p38 kinase inhibitor is mediated through Oct-1. Mutation in octamer sequence significantly reduced the SB202190-stimulated U6 promoter transcription and the distance between octamer and proximal sequence element of U6 promoter is also critical for the p38 kinase inhibitor-stimulated activity. Exogenous Oct-1 expression showed a concentration-dependent activation of U6 promoter that was further stimulated by the p38 kinase inhibitors. When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors. Over-expression of p38 alpha kinase down-regulated U6 promoter activity and this inhibition was further enhanced by PMA and p38 kinase inhibitors reversed this inhibition. p38 kinase inhibitor-treated cells had 50% more U6 RNA than the control cells. Taken together, our results show a negative correlation between the p38 kinase levels and Oct-1 binding on U6 promoter, suggesting that U6 promoter is negatively regulated by p38 kinase. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Lin, Bor-Ruei; Natarajan, Ven] NCI, SAIC Frederick, Frederick, MD 21702 USA.
RP Lin, BR (reprint author), NCI, SAIC Frederick, 1050 Boyles St, Frederick, MD 21702 USA.
EM linbr@mail.nih.gov; vnatarajan@mail.nih.gov
FU National Institute of Allergy and Infectious Diseases; National Cancer
Institute, National Institutes of Health [HHSN261200800001E]
FX This work was supported by the National Institute of Allergy and
Infectious Diseases. This project has been funded in whole or in part
with federal funds from the National Cancer Institute, National
Institutes of Health, under contract [HHSN261200800001E]. The content of
this publication does not necessarily reflect the views or policies of
the Department of Health and Human Services, nor does mention of trade
names, commercial products, or organizations imply endorsement by the
U.S. Government.
NR 60
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U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD APR 15
PY 2012
VL 497
IS 2
BP 200
EP 207
DI 10.1016/j.gene.2012.01.041
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 922YH
UT WOS:000302584300009
PM 22310390
ER
PT J
AU Yi, L
Donsante, A
Kennerson, ML
Mercer, JFB
Garbern, JY
Kaler, SG
AF Yi, Ling
Donsante, Anthony
Kennerson, Marina L.
Mercer, Julian F. B.
Garbern, James Y.
Kaler, Stephen G.
TI Altered intracellular localization and valosin-containing protein (p97
VCP) interaction underlie ATP7A-related distal motor neuropathy
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID COPPER-DEFICIENCY MYELONEUROPATHY; INCLUSION-BODY MYOPATHY;
OCCIPITAL-HORN-SYNDROME; MENKES-DISEASE; NEURON DISEASE; FRONTOTEMPORAL
DEMENTIA; REGULATED TRAFFICKING; HIPPOCAMPAL-NEURONS; MUSCULAR-ATROPHY;
PLASMA-MEMBRANE
AB ATP7A is a P-type ATPase that regulates cellular copper homeostasis by activity at the trans-Golgi network (TGN) and plasma membrane (PM), with the location normally governed by intracellular copper concentration. Defects in ATP7A lead to Menkes disease or its milder variant, occipital horn syndrome or to a newly discovered condition, ATP7A-related distal motor neuropathy (DMN), for which the precise pathophysiology has been obscure. We investigated two ATP7A motor neuropathy mutations (T994I, P1386S) previously associated with abnormal intracellular trafficking. In the patients fibroblasts, total internal reflection fluorescence microscopy indicated a shift in steady-state equilibrium of ATP7A(T994I) and ATP7A(P1386S), with exaggerated PM localization. Transfection of Hek293T cells and NSC-34 motor neurons with the mutant alleles tagged with the Venus fluorescent protein also revealed excess PM localization. Endocytic retrieval of the mutant alleles from the PM to the TGN was impaired. Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia. Small-interfering RNA (SiRNA) knockdown of p97/VCP corrected ATP7A(T994I) mislocalization. Flow cytometry documented that non-permeabilized ATP7A(P1386S) fibroblasts bound a carboxyl-terminal ATP7A antibody, consistent with relocation of the ATP7A di-leucine endocytic retrieval signal to the extracellular surface and partially destabilized insertion of the eighth transmembrane helix. Our findings illuminate the mechanisms underlying ATP7A-related DMN and establish a link between p97/VCP and genetically distinct forms of motor neuron degeneration.
C1 [Yi, Ling; Donsante, Anthony; Kaler, Stephen G.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Human Copper Metab, Program Mol Med, Bethesda, MD USA.
[Kennerson, Marina L.] Univ Sydney, ANZAC Res Inst, Northcott Neurosci Lab, Concord, Australia.
[Mercer, Julian F. B.] Deakin Univ, Sch Life & Environm Sci, Ctr Cellular & Mol Biol, Burwood, Australia.
[Garbern, James Y.] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA.
[Garbern, James Y.] Univ Rochester, Sch Med & Dent, Ctr Translat Neuromed, Rochester, NY 14642 USA.
RP Kaler, SG (reprint author), NIH, Bldg 10,Room 10N313,10 Ctr Dr,MSC 1853, Bethesda, MD 20892 USA.
EM kalers@mail.nih.gov
RI Kennerson, Marina/B-5058-2014
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health
FX The work was supported by the Intramural Research Program of the Eunice
Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health.
NR 50
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U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 15
PY 2012
VL 21
IS 8
BP 1794
EP 1807
DI 10.1093/hmg/ddr612
PG 14
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 919DS
UT WOS:000302302400010
PM 22210628
ER
PT J
AU Liu, CQ
Bakeri, H
Li, TS
Swaroop, A
AF Liu, Chunqiao
Bakeri, Hirva
Li, Tiansen
Swaroop, Anand
TI Regulation of retinal progenitor expansion by Frizzled receptors:
implications for microphthalmia and retinal coloboma
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID INTERKINETIC NUCLEAR MIGRATION; GANGLION-CELL; SONIC HEDGEHOG;
VERTEBRATE RETINA; MOUSE RETINA; TRANSCRIPTION FACTORS; FATE
DETERMINATION; NEURAL DEVELOPMENT; MAMMALIAN RETINA; NERVOUS-SYSTEM
AB Nineteen Wnt ligands and 10 Frizzled (Fz) receptors mediate multiple distinct cellular events during neuronal development. However, their precise roles in cell-type specification and organogenesis are poorly delineated because of overlapping functions and expression profiles. Here, we have explored the role of two closely related Frizzled receptors, Fz5 and Fz8, in mouse retinal development. We previously showed that Fz5(/) mice exhibit mild coloboma and microphthalmia at approximate to 50 penetrance. Fz8 expression overlaps with Fz5 in the neural retina and optic fissure/disc. Mice lacking Fz8 show minimal eye and retinal defects. The embryos lacking both Fz5 and Fz8 die early in development, but a majority of triallelic Fz5(/);Fz8(/) mutants survive until birth. The triallelic mutant develops severe retinal coloboma and microphthalmia with full penetrance. At the cellular level, impaired neurogenesis is indicated by increased early-born retinal neurons that result from accelerated cell cycle exit of progenitors. Deficiency of apical retinal neuroepithelium is indicated by altered localization of apical junction markers, such as atypical protein kinase C, RhoA and -catenin. Hes1 expression, which is critical for retinal progenitor expansion, is down-regulated in the triallelic mutant mouse. Furthermore, blocking Frizzled receptors in cultured retinal explants led to basally shifted divisions of retinal progenitors. Together, our studies suggest a dose-dependent regulation of signaling by Fz5 and Fz8 in optic fissure/disc formation and progenitor expansion.
C1 [Liu, Chunqiao; Bakeri, Hirva; Li, Tiansen; Swaroop, Anand] NEI, N NRL, Bethesda, MD 20892 USA.
RP Liu, CQ (reprint author), NEI, N NRL, MSC0610,6 Ctr Dr, Bethesda, MD 20892 USA.
EM cqliu@nei.nih.gov; swaroopa@nei.nih.gov
RI Liu, Chunqiao/O-3391-2013;
OI Liu, Chunqiao/0000-0002-0299-7401; Swaroop, Anand/0000-0002-1975-1141
FU National Eye Institute
FX This research was supported by intramural program of the National Eye
Institute.
NR 59
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U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 15
PY 2012
VL 21
IS 8
BP 1848
EP 1860
DI 10.1093/hmg/ddr616
PG 13
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 919DS
UT WOS:000302302400014
PM 22228100
ER
PT J
AU Tang, W
Fu, YP
Figueroa, JD
Malats, N
Garcia-Closas, M
Chatterjee, N
Kogevinas, M
Baris, D
Thun, M
Hall, JL
De Vivo, I
Albanes, D
Porter-Gill, P
Purdue, MP
Burdett, L
Liu, LY
Hutchinson, A
Myers, T
Tardon, A
Serra, C
Carrato, A
Garcia-Closas, R
Lloreta, J
Johnson, A
Schwenn, M
Karagas, MR
Schned, A
Black, A
Jacobs, EJ
Diver, WR
Gapstur, SM
Virtamo, J
Hunter, DJ
Fraumeni, JF
Chanock, SJ
Silverman, DT
Rothman, N
Prokunina-Olsson, L
AF Tang, Wei
Fu, Yi-Ping
Figueroa, Jonine D.
Malats, Nuria
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Kogevinas, Manolis
Baris, Dalsu
Thun, Michael
Hall, Jennifer L.
De Vivo, Immaculata
Albanes, Demetrius
Porter-Gill, Patricia
Purdue, Mark P.
Burdett, Laurie
Liu, Luyang
Hutchinson, Amy
Myers, Timothy
Tardon, Adonina
Serra, Consol
Carrato, Alfredo
Garcia-Closas, Reina
Lloreta, Josep
Johnson, Alison
Schwenn, Molly
Karagas, Margaret R.
Schned, Alan
Black, Amanda
Jacobs, Eric J.
Diver, W. Ryan
Gapstur, Susan M.
Virtamo, Jarmo
Hunter, David J.
Fraumeni, Joseph F., Jr.
Chanock, Stephen J.
Silverman, Debra T.
Rothman, Nathaniel
Prokunina-Olsson, Ludmila
TI Mapping of the UGT1A locus identifies an uncommon coding variant that
affects mRNA expression and protects from bladder cancer
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; HUMAN UDP-GLUCURONOSYLTRANSFERASES;
CLINICAL-APPLICATION; COMPLEX DISEASES; BILIRUBIN LEVELS; RARE VARIANTS;
GENE-COMPLEX; URINARY PH; NAT2 GENES; POLYMORPHISMS
AB A recent genome-wide association study of bladder cancer identified the UGT1A gene cluster on chromosome 2q37.1 as a novel susceptibility locus. The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal of aromatic amines. Bioactivated forms of aromatic amines found in tobacco smoke and industrial chemicals are the main risk factors for bladder cancer. The association within the UGT1A locus was detected by a single nucleotide polymorphism (SNP) rs11892031. Now, we performed detailed resequencing, imputation and genotyping in this region. We clarified the original genetic association detected by rs11892031 and identified an uncommon SNP rs17863783 that explained and strengthened the association in this region (allele frequency 0.014 in 4035 cases and 0.025 in 5284 controls, OR 0.55, 95CI 0.440.69, P 3.3 10(7)). Rs17863783 is a synonymous coding variant Val209Val within the functional UGT1A6.1 splicing form, strongly expressed in the liver, kidney and bladder. We found the protective T allele of rs17863783 to be associated with increased mRNA expression of UGT1A6.1 in in-vitro exontrap assays and in human liver tissue samples. We suggest that rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer.
C1 [Prokunina-Olsson, Ludmila] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Malats, Nuria] Spanish Natl Canc Res Ctr, Madrid 28029, Spain.
[Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
[Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.
[Kogevinas, Manolis] Municipal Inst Med Res, Barcelona 08003, Spain.
[Kogevinas, Manolis; Tardon, Adonina] CIBERESP, Barcelona 08003, Spain.
[Kogevinas, Manolis] Natl Sch Publ Hlth, Athens 11521, Greece.
[Thun, Michael; Jacobs, Eric J.; Diver, W. Ryan; Gapstur, Susan M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA.
[Hall, Jennifer L.] Univ Minnesota, Lillehei Heart Inst, Dept Med, Minneapolis, MN 55455 USA.
[De Vivo, Immaculata] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.
[Burdett, Laurie; Hutchinson, Amy; Myers, Timothy] NCI, Core Genotype Facil, SAIC Frederick Inc, Frederick, MD 21702 USA.
[Tardon, Adonina] Univ Oviedo, Oviedo 33003, Spain.
[Serra, Consol] Univ Pompeu Fabra, Barcelona 08002, Spain.
[Carrato, Alfredo] Ramon y Cajal Univ Hosp, Madrid 28034, Spain.
[Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna 38320, Spain.
[Lloreta, Josep] Univ Pompeu Fabra, Hosp Mar, IMIM, Barcelona 08003, Spain.
[Johnson, Alison] Vermont Canc Registry, Burlington, VT 05401 USA.
[Schwenn, Molly] Maine Canc Registry, Augusta, ME 04333 USA.
[Karagas, Margaret R.] Dartmouth Med Sch, Hanover, NH 03755 USA.
[Schned, Alan] Washington Univ, Sch Med, Dept Urol, St Louis, MO 63110 USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki 00271, Finland.
[Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA.
RP Prokunina-Olsson, L (reprint author), NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 USA.
EM prokuninal@mail.nih.gov
RI Tang, Wei/H-7103-2013; Serra, C/E-6879-2014; Lloreta, J/I-2112-2014;
Albanes, Demetrius/B-9749-2015; Garcia-Closas, Montserrat /F-3871-2015;
Malats, Nuria/H-7041-2015; Purdue, Mark/C-9228-2016; Kogevinas,
Manolis/C-3918-2017
OI Tang, Wei/0000-0002-7089-4391; Prokunina-Olsson,
Ludmila/0000-0002-9622-2091; Serra, C/0000-0001-8337-8356; Lloreta,
J/0000-0003-1644-9470; Garcia-Closas, Montserrat /0000-0003-1033-2650;
Malats, Nuria/0000-0003-2538-3784; Purdue, Mark/0000-0003-1177-3108;
FU National Institutes of Health, National Cancer Institute
[HHSN261200800001E]; Centro Nacional de Investigaciones Oncologicas,
Madrid, Spain; DCEG, NCI/NIH, Rockville, MD, USA; Information Management
Services, Silver Spring, MD, USA; Institut Municipal d'Investigacio
Medica, Barcelona, Spain; Westat, Inc., Rockville, MD, USA; Marques de
Valdecilla University Hospital, Santander, Cantabria, Spain; Hospital
Ciudad de Coria, Coria (Caceres), Spain; Westat, Rockville, MD, USA;
Information Management Services, Inc., Silver Spring, MD, USA; SBCS of
the National Institutes of Health, National Cancer Institute, Division
of Cancer Epidemiology and Genetics and intramural [NCI N02-CP-11015];
FIS/Spain [98/1274, 00/0745, PI061614, G03/174]; Fundacio Marato TV3;
Red Tematica Investigacion Cooperativa en Cancer (RTICC); Consolider
ONCOBIO; NEBCS of the National Institutes of Health, National Cancer
Institute, Division of Cancer Epidemiology and Genetics and intramural
[NCI N02-CP-01037]; PLCO -The NIH Genes, Environment and Health
Initiative (GEI); DNA extraction and statistical analyses
[HG-06-033-NCI-01, RO1HL091172-01]; Johns Hopkins University Center for
Inherited Disease Research [U01HG004438, HHSN268200782096C]; GENEVA -The
NIH Genes, Environment and Health Initiative [GEI] [HG-06-033-NCI-01,
RO1HL091172-01]; GENEVA Coordination Center [U01 HG004446]; National
Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics;
Division of Cancer Epidemiology and Genetics; Division of Cancer
Prevention, National Cancer Institute, National Institutes of Health,
ATBC; NIH; National Cancer Institute; US Public Health Service from the
National Cancer Institute, Department of Health and Human Services
[N01-CN-45165, N01-RC-45035, N01-RC-37004]; NHS; HPFS [CA055075,
CA087969]; [EU-FP7-201663]; [RO1-CA089715]; [CA34627]
FX The NCI bladder cancer GWAS and follow-up studies are supported by the
intramural research program of the National Institutes of Health,
National Cancer Institute.; Following individuals are acknowledged for
their support: Francisco Real (Molecular Pathology Programme, Centro
Nacional de Investigaciones Oncologicas, Madrid, Spain). Marie-Joseph
Horner (DCEG, NCI/NIH, Rockville, MD, USA). Adam Mumy (DCEG, NCI/NIH,
Rockville, MD, USA). Natalia Orduz (DCEG, NCI/NIH, Rockville, MD, USA).
Leslie Carroll (Information Management Services, Silver Spring, MD,
USA). Gemma Castano-Vinyals (Institut Municipal d'Investigacio Medica,
Barcelona, Spain). Fernando Fernandez (Institut Municipal d'Investigacio
Medica, Barcelona, Spain). Paul Hurwitz (Westat, Inc., Rockville, MD,
USA). Charles Lawrence (Westat, Inc., Rockville, MD, USA). Marta
Lopez-Brea (Marques de Valdecilla University Hospital, Santander,
Cantabria, Spain). Anna McIntosh (Westat, Inc., Rockville, MD, USA).
Angeles Panadero (Hospital Ciudad de Coria, Coria (Caceres), Spain).
Fernando Rivera (Marques de Valdecilla University Hospital, Santander,
Cantabria, Spain). Robert Saal (Westat, Rockville, MD, USA). Maria Sala
(Institut Municipal d'Investigacio Medica, Barcelona, Spain). Kirk
Snyder (Information Management Services, Inc., Silver Spring, MD, USA).
Anne Taylor (Information Management Services, Inc., Silver Spring, MD,
USA). Montserrat Tora (Institut Municipal d'Investigacio Medica,
Barcelona, Spain). Jane Wang (Information Management Services, Silver
Spring, MD, USA).; This project has been funded in part with federal
funds from the National Cancer, Institute, National Institutes of
Health, under Contract No. HHSN261200800001E. The content of this
publication does not necessarily reflect the views or policies of the
Department of Health and Human Services, nor does mention of trade
names, commercial products, or organizations imply endorsement by the US
Government. The funders had no role in study design, data collection and
analysis, decision to publish or preparation of the manuscript.; Support
for individual studies that participated in the effort is as follows:
SBCS (D.T.S.)-Intramural Research Program of the National Institutes of
Health, National Cancer Institute, Division of Cancer Epidemiology and
Genetics and intramural, contract number NCI N02-CP-11015. FIS/Spain
98/1274, FIS/Spain 00/0745, PI061614 and G03/174, Fundacio Marato TV3,
Red Tematica Investigacion Cooperativa en Cancer (RTICC), Consolider
ONCOBIO, EU-FP7-201663; and RO1-CA089715 and CA34627. NEBCS
(D.T.S.)-Intramural research program of the National Institutes of
Health, National Cancer Institute, Division of Cancer Epidemiology and
Genetics and intramural, contract number NCI N02-CP-01037, PLCO
(M.P.P.)-The NIH Genes, Environment and Health Initiative (GEI) partly
funded, DNA extraction and statistical analyses (HG-06-033-NCI-01 and
RO1HL091172-01), genotyping at the Johns Hopkins University Center for
Inherited Disease Research (U01HG004438 and NIH HHSN268200782096C) and
study coordination at the GENEVA (N.C.)-The NIH Genes, Environment and
Health Initiative [GEI] partly funded DNA extraction and statistical
analyses (HG-06-033-NCI-01 and RO1HL091172-01), genotyping at the Johns
Hopkins University Center for Inherited Disease Research (U01HG004438
and NIH HHSN268200782096C) and study coordination at the GENEVA
Coordination Center (U01 HG004446) for EAGLE and part of PLCO studies.
Genotyping for the remaining part of PLCO and all ATBC and CPS-II
samples were supported by the Intramural Research Program of the
National Institutes of Health, NCI, Division of Cancer Epidemiology and
Genetics. The PLCO is supported by the Intramural Research Program of
the Division of Cancer Epidemiology and Genetics and supported by
contracts from the Division of Cancer Prevention, National Cancer
Institute, National Institutes of Health, ATBC (D.A.)-This research was
supported in part by the Intramural Research Program of the NIH and the
National Cancer Institute. Additionally, this research was supported by
US Public Health Service contracts N01-CN-45165, N01-RC-45035 and
N01-RC-37004 from the National Cancer Institute, Department of Health
and Human Services. NHS & HPFS (I.D.V.)-CA055075 and CA087969.
NR 64
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U1 2
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 15
PY 2012
VL 21
IS 8
BP 1918
EP 1930
DI 10.1093/hmg/ddr619
PG 13
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 919DS
UT WOS:000302302400020
PM 22228101
ER
PT J
AU Dooley, KE
Park, JG
Swindells, S
Allen, R
Haas, DW
Cramer, Y
Aweeka, F
Wiggins, I
Gupta, A
Lizak, P
Qasba, S
van Heeswijk, R
Flexner, C
AF Dooley, Kelly E.
Park, Jeong-Gun
Swindells, Susan
Allen, Reena
Haas, David W.
Cramer, Yoninah
Aweeka, Francesca
Wiggins, Ilene
Gupta, Amita
Lizak, Patricia
Qasba, Sonia
van Heeswijk, Rolf
Flexner, Charles
CA ACTG 5267 Study Team
TI Safety, Tolerability, and Pharmacokinetic Interactions of the
Antituberculous Agent TMC207 (Bedaquiline) With Efavirenz in Healthy
Volunteers: AIDS Clinical Trials Group Study A5267
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE bedaquiline; efavirenz; CYP3A; HIV; pharmacokinetics; TMC207;
tuberculosis
ID MULTIDRUG-RESISTANT TUBERCULOSIS; DRUG-INDUCED PHOSPHOLIPIDOSIS;
ANTIRETROVIRAL THERAPY; MYCOBACTERIUM-TUBERCULOSIS; DIARYLQUINOLINE
TMC207; ATP SYNTHASE; R207910; CYP2B6; MODEL; PYRAZINAMIDE
AB Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral drug efavirenz.
Methods: This was a phase 1 pharmacokinetic drug interaction trial. Each healthy volunteer received two 400 mg doses of bedaquiline, the first alone and the second with concomitant steady-state efavirenz. Plasma pharmacokinetic sampling for bedaquiline and its N-monodesmethyl metabolite was performed over 14 days after each bedaquiline dose. Steady-state efavirenz pharmacokinetics were also determined. Efavirenz metabolizer status was based on CYP2B6 composite 516/983 genotype.
Results: Thirty-three of 37 enrolled subjects completed the study. Geometric mean of ratios for bedaquiline with efavirenz versus bedaquiline alone were 0.82 [90% confidence interval (CI): 0.75 to 0.89] for the 14-day area under the concentration-time curve (AUC(0-336) (h)) and 1.00 (90% CI: 0.88 to 1.13) for the maximum concentration (C-max). For N-monodesmethyl metabolite, the geometric mean of ratios was 1.07 (90% CI: 0.97 to 1.19) for AUC(0-336 h) and 1.89 (90% CI: 1.66 to 2.15) for C-max. There were no grade 3 or 4 clinical adverse events. One subject developed asymptomatic grade 3 serum transaminase elevation, prompting study drug discontinuation. Efavirenz concentrations stratified by CYP2B6 genotype were similar to historical data.
Conclusions: Single-dose bedaquiline was well tolerated alone and with steady-state efavirenz. The effect of efavirenz on bedaquiline concentrations is unlikely to be clinically significant.
C1 [Dooley, Kelly E.; Wiggins, Ilene; Gupta, Amita; Flexner, Charles] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA.
[Park, Jeong-Gun; Cramer, Yoninah] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Swindells, Susan] Univ Nebraska Med Ctr, Omaha, NE USA.
[Allen, Reena] AIDS Clin Trials Grp Operat, Silver Spring, MD USA.
NIH, Div Aids, Bethesda, MD 20892 USA.
[Haas, David W.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
[Aweeka, Francesca; Lizak, Patricia] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[van Heeswijk, Rolf] Tibotec, BVBA, Mechelen, Belgium.
[Qasba, Sonia] Montgomery Cty Dept Hlth & Human Serv, Silver Spring, MD USA.
RP Dooley, KE (reprint author), Johns Hopkins Univ, Sch Med, 600 N Wolfe St,Osler 527, Baltimore, MD 21287 USA.
EM kdooley1@jhmi.edu
FU AIDS Clinical Trials Group; National Institute of Allergy and Infectious
Diseases; NCRR/NI [UL1 RR024975, U01-AI06439]; ACTG [5-U01 AI069423];
CTSA [UL 1RR 025747 CTSA]; National Center of Research Resources of the
NIH [U01 AI069474, UL1-RR025755]; RPh-Johns Hopkins Adult AIDS CRS Site
201 CTU [AI69465]; GCRC [U54-RR023561]; [U01 AI068636]; [AI068634];
[U01 AI069497]; [U01 AI069465]; [AI0699450]; [U01 AI069439]; [R01
AI077505]; [K23AI080842]
FX Supported by the AIDS Clinical Trials Group sponsored by the National
Institute of Allergy and Infectious Diseases and was supported by the
following grants: U01 AI068636 and AI068634, U01 AI069497 (A.G.), U01
AI069465 (A.G., C.F., I.W.) AI0699450 (S.S.), U01 AI069439, R01 AI077505
(D.W.H.), and K23AI080842 (K.E.D.). The AIDS Clinical Trials Group Human
DNA Repository is supported in part by grant UL1 RR024975. Tibotec
Pharmaceuticals and Bristol-Myers Squibb provided study medications.;
Deborah Sutherland, RN, BSN, CCRP and Marcia Free, RN, BSN,
CCRP-Vanderbilt Therapeutics Clinical Research Site #3652 NIH/ACTG Grant
U01-AI06439, Vanderbilt CTSA grant UL1 RR024975 from NCRR/NI#.; Miriam
Chicurel, BS, BSN and Charles W. Tedder, BA- UNC AIDS Clinical Trials
Unit Site 3201, ACTG Grant 5-U01 AI069423, CTSA Grant UL 1RR 025747
CTSA.; Susan L. Koletar, MD and Heather Harber, RN-The Ohio State
University, 2301 ACTG Grant U01 AI069474, Clinical Research Center,
Grant UL1-RR025755 from the National Center of Research Resources of the
NIH.; Annie Luetkemeyer, MD and Jay Dwyer, RN- UCSF AIDS CRS Site 801
Grant # 5UO1 AI069502. Judith Hackman, RN and Andrea Weiss, RPh-Johns
Hopkins Adult AIDS CRS Site 201 CTU Grant AI69465; GCRC Grant
U54-RR023561.
NR 36
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U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 15
PY 2012
VL 59
IS 5
BP 455
EP 462
DI 10.1097/QAI.0b013e3182410503
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 917BQ
UT WOS:000302147400010
PM 22126739
ER
PT J
AU Kundu, P
Inati, SJ
Evans, JW
Luh, WM
Bandettini, PA
AF Kundu, Prantik
Inati, Souheil J.
Evans, Jennifer W.
Luh, Wen-Ming
Bandettini, Peter A.
TI Differentiating BOLD and non-BOLD signals in fMRI time series using
multi-echo EPI
SO NEUROIMAGE
LA English
DT Article
DE fMRI; Resting state; Multi-echo; BOLD; TE dependence; ICA; Denoising;
Subcortical; Connectivity
ID INDEPENDENT COMPONENT ANALYSIS; HUMAN BRAIN-FUNCTION; FUNCTIONAL
CONNECTIVITY; CONTRAST SENSITIVITY; SENSORY STIMULATION; 1.5 T; MRI;
ACTIVATION; NOISE; OXYGENATION
AB A central challenge in the fMRI based study of functional connectivity is distinguishing neuronally related signal fluctuations from the effects of motion, physiology, and other nuisance sources. Conventional techniques for removing nuisance effects include modeling of noise time courses based on external measurements followed by temporal filtering. These techniques have limited effectiveness. Previous studies have shown using multi-echo fMRI that neuronally related fluctuations are Blood Oxygen Level Dependent (BOLD) signals that can be characterized in terms of changes in R-2* and initial signal intensity (S-0) based on the analysis of echo-time (TE) dependence. We hypothesized that if TE-dependence could be used to differentiate BOLD and non-BOLD signals, non-BOLD signal could be removed to denoise data without conventional noise modeling. To test this hypothesis, whole brain multi-echo data were acquired at 3 TEs and decomposed with Independent Components Analysis (ICA) after spatially concatenating data across space and TE. Components were analyzed for the degree to which their signal changes fit models for R-2* and S-0 change, and summary scores were developed to characterize each component as BOLD-like or not BOLD-like. These scores clearly differentiated BOLD-like "functional network" components from non BOLD-like components related to motion, pulsatility, and other nuisance effects. Using non BOLD-like component time courses as noise regressors dramatically improved seed-based correlation mapping by reducing the effects of high and low frequency non-BOLD fluctuations. A comparison with seed-based correlation mapping using conventional noise regressors demonstrated the superiority of the proposed technique for both individual and group level seed-based connectivity analysis, especially in mapping subcortical-cortical connectivity. The differentiation of BOLD and non-BOLD components based on TE-dependence was highly robust, which allowed for the identification of BOLD-like components and the removal of non BOLD-like components to be implemented as a fully automated procedure. Published by Elsevier Inc.
C1 [Kundu, Prantik; Evans, Jennifer W.; Bandettini, Peter A.] NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
[Inati, Souheil J.; Luh, Wen-Ming; Bandettini, Peter A.] NIMH, Funct MRI Facil, NIH, Bethesda, MD 20892 USA.
[Kundu, Prantik] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England.
[Evans, Jennifer W.] Henry M Jackson Fdn, Ctr Neurosci & Regenerat Med, Rockville, MD 20852 USA.
RP Kundu, P (reprint author), NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
EM kundup@mail.nih.gov
OI Inati, Souheil/0000-0001-5596-9554; Kundu, Prantik/0000-0001-9367-3068
FU National Institute of Mental Health; NIH-Cambridge
FX This work was funded by the National Institute of Mental Health
Intramural Research Program. Prantik Kundu is supported by the
NIH-Cambridge Scholars program.
NR 46
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Z9 77
U1 2
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD APR 15
PY 2012
VL 60
IS 3
BP 1759
EP 1770
DI 10.1016/j.neuroimage.2011.12.028
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 917TZ
UT WOS:000302202800017
PM 22209809
ER
PT J
AU Misaki, M
Wallace, GL
Dankner, N
Martin, A
Bandettini, PA
AF Misaki, Masaya
Wallace, Gregory L.
Dankner, Nathan
Martin, Alex
Bandettini, Peter A.
TI Characteristic cortical thickness patterns in adolescents with autism
spectrum disorders: Interactions with age and intellectual ability
revealed by canonical correlation analysis
SO NEUROIMAGE
LA English
DT Article
DE Autism spectrum disorders; Kernel canonical correlation analysis;
Varimax rotation; Cortical thickness; Developmental change
ID SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; DIAGNOSTIC INTERVIEW;
BRAIN-DEVELOPMENT; MRI; VOLUME; CHILDREN; SYSTEM; IQ
AB To investigate patterns and correlates of cortical thickness in adolescent males with autism spectrum disorders (ASD) versus matched typically developing controls, we applied kernel canonical correlation analysis to whole brain cortical thickness with the explaining variables of diagnosis, age, full-scale IQ and their interactions. The analysis found that canonical variates (patterns of cortical thickness) correlated with each of these variables. The diagnosis- and age-by-diagnosis-related canonical variates showed thinner cortex for participants with ASD, which is consistent with previous studies using a univariate analysis. In addition, the multivariate statistics found larger affected regions with higher sensitivity than those found using univariate analysis. An IQ-related effect was also found with the multivariate analysis. The effects of IQ and age-by-IQ interaction on cortical thickness differed between the diagnostic groups. For typically developing adolescents, IQ was positively correlated with cortical thickness in orbitofrontal, postcentral and superior temporal regions, and greater thinning with age was seen in dorsal frontal areas in the superior IQ (> 120) group. These associations between IQ and cortical thickness were not seen in the ASD group. Differing relationships between IQ and cortical thickness implies independent associations between measures of intelligence and brain structure in ASD versus typically developing controls. We discuss these findings vis-a-vis prior results obtained utilizing univariate methods. Published by Elsevier Inc.
C1 [Misaki, Masaya; Wallace, Gregory L.; Dankner, Nathan; Martin, Alex; Bandettini, Peter A.] NIMH, Lab Brain & Cognit, NIH, Bethesda, MD USA.
RP Misaki, M (reprint author), Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA.
EM mamisaki@gmail.com
RI martin, alex/B-6176-2009;
OI Wallace, Gregory/0000-0003-0329-5054
FU National Institutes of Health, National Institute of Mental Health
(NIMH)
FX This study was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Mental Health
(NIMH).
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U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD APR 15
PY 2012
VL 60
IS 3
BP 1890
EP 1901
DI 10.1016/j.neuroimage.2012.01.120
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 917TZ
UT WOS:000302202800029
PM 22326986
ER
PT J
AU Wehr, NB
Levine, RL
AF Wehr, Nancy B.
Levine, Rodney L.
TI Quantitation of protein carbonylation by dot blot
SO ANALYTICAL BIOCHEMISTRY
LA English
DT Article
DE Protein carbonylation; 2,4-Dinitrophenylhydrazine; Oxidative stress;
Immunoblot; Dot blot
ID OXIDATIVELY MODIFIED PROTEINS; GLUTAMINE-SYNTHETASE; RESIDUES
AB Protein carbonylation is the most commonly used measure of oxidative modification of proteins. It is frequently measured spectrophotometrically or immunochemically by derivatizing proteins with the classical carbonyl reagent, 2,4-dinitrophenylhydrazine. We developed an immunochemical dot blot method for quantitation of protein carbonylation in homogenates or purified proteins. Dimethyl sulfoxide was employed as the solvent because it very efficiently extracts proteins from tissues and keeps them soluble. It also readily dissolves 2,4-dinitrophenylhydrazine and wets polyvinylidene difluoride (PVDF) membranes. The detection limit is 0.19 +/- 0.04 pmol of carbonyl, and 60 ng of protein is sufficient to measure protein carbonyl content. This level of sensitivity allowed measurement of protein carbonylation in individual Drosophila. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Wehr, Nancy B.; Levine, Rodney L.] NHLBI, Biochem Lab, Bethesda, MD 20892 USA.
RP Levine, RL (reprint author), NHLBI, Biochem Lab, Bldg 3, Bethesda, MD 20892 USA.
EM rlevine@nih.gov
RI Levine, Rodney/D-9885-2011
FU National Heart, Lung, and Blood Institute
FX This research was supported by the Intramural Research Program of the
National Heart, Lung, and Blood Institute. We thank Barbara Berlett and
Elena Gaidamakova for performing the gamma irradiations.
NR 19
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U1 0
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0003-2697
J9 ANAL BIOCHEM
JI Anal. Biochem.
PD APR 15
PY 2012
VL 423
IS 2
BP 241
EP 245
DI 10.1016/j.ab.2012.01.031
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 919NY
UT WOS:000302336100009
PM 22326366
ER
PT J
AU Zhang, B
Noble, PL
Winslow, JT
Pine, DS
Nelson, EE
AF Zhang, Bo
Noble, Pamela L.
Winslow, James T.
Pine, Daniel S.
Nelson, Eric E.
TI Amygdala volume predicts patterns of eye fixation in rhesus monkeys
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Face recognition; MRI; Social; Affiliative; Gaze
ID FACIAL-EXPRESSION; NEURAL RESPONSES; SOCIAL ANXIETY; MACACA-MULATTA;
AUTISM; GAZE; FACE; ADOLESCENTS; BEHAVIOR; PRIMATE
AB In both human and nonhuman primates the eyes are a highly salient feature of the face, conveying identity, emotion and attentional direction of conspecifics. Studies have indicated that the amygdala plays an important role in eye contact, and amygdala dysfunction may underlie social deficits in disorders such as autism through effects on eye contact. In the present study we compared the volume of the amygdala in 32 juvenile rhesus monkeys to visual fixation patterns in a social memory paradigm. Amygdala volume was determined from manual traces of structural MRIs and fixation patterns were assessed using eyetracking methodology. A significant positive relationship was found between amygdala volume and fixation on both the face and the eye region. Amygdala volume was also found to relate to habituation across multiple presentations of different photographs of the same individual monkeys indicating a role in social memory. These data provide an important linkage between structural variation of amygdala and previous demonstrations of function in a nonhuman primate model. Published by Elsevier B.V.
C1 [Zhang, Bo; Pine, Daniel S.; Nelson, Eric E.] NIMH, Emot & Affect Neurosci Branch, Bethesda, MD 20892 USA.
[Noble, Pamela L.; Winslow, James T.] NIMH, Nonhuman Primate Core Facil, Bethesda, MD 20892 USA.
RP Nelson, EE (reprint author), NIMH, Emot & Affect Neurosci Branch, Bldg 15K, Bethesda, MD 20892 USA.
EM nelson@mail.nih.gov
RI Nelson, Eric/B-8980-2008
OI Nelson, Eric/0000-0002-3376-2453
FU National Institutes of Health, NIMH
FX The work presented here was supported entirely by the intramural
research program of the National Institutes of Health, NIMH. The authors
wish to acknowledge the technical assistance and training in amygdala
tracing provided by Julia Scott at the University of California - Davis.
We also are indebted to the veterinary and animal care staff of the NIH
animal facility in Poolesville and all of the staff at the NIMH primate
core.
NR 27
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U1 2
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 15
PY 2012
VL 229
IS 2
BP 433
EP 437
DI 10.1016/j.bbr.2012.01.009
PG 5
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 915TM
UT WOS:000302050300018
PM 22285417
ER
PT J
AU Gwamaka, M
Kurtis, JD
Sorensen, BE
Holte, S
Morrison, R
Mutabingwa, TK
Fried, M
Duffy, PE
AF Gwamaka, Moses
Kurtis, Jonathan D.
Sorensen, Bess E.
Holte, Sarah
Morrison, Robert
Mutabingwa, Theonest K.
Fried, Michal
Duffy, Patrick E.
TI Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria
and Death in Young Children
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID SERUM TRANSFERRIN RECEPTOR; PLACEBO-CONTROLLED TRIAL; CHELATION-THERAPY;
CEREBRAL MALARIA; GAMBIAN CHILDREN; PREGNANT-WOMEN; ORAL IRON; ANEMIA;
SUPPLEMENTATION; MORTALITY
AB Background. Iron supplementation may increase malaria morbidity and mortality, but the effect of naturally occurring variation in iron status on malaria risk is not well studied.
Methods. A total of 785 Tanzanian children living in an area of intense malaria transmission were enrolled at birth, and intensively monitored for parasitemia and illness including malaria for up to 3 years, with an average of 47 blood smears. We assayed plasma samples collected at routine healthy-child visits, and evaluated the impact of iron deficiency (ID) on future malaria outcomes and mortality.
Results. ID at routine, well-child visits significantly decreased the odds of subsequent parasitemia (23% decrease, P < .001) and subsequent severe malaria (38% decrease, P = .04). ID was also associated with 60% lower all-cause mortality (P = .04) and 66% lower malaria-associated mortality (P = .11). When sick visits as well as routine healthy-child visits are included in analyses (average of 3 iron status assays/child), ID reduced the prevalence of parasitemia (6.6-fold), hyperparasitemia (24.0-fold), and severe malaria (4.0-fold) at the time of sample collection (all P < .001).
Conclusions. Malaria risk is influenced by physiologic iron status, and therefore iron supplementation may have adverse effects even among children with ID. Future interventional studies should assess whether treatment for ID coupled with effective malaria control can mitigate the risks of iron supplementation for children in areas of malaria transmission.
C1 [Fried, Michal; Duffy, Patrick E.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD 20852 USA.
[Gwamaka, Moses; Sorensen, Bess E.; Morrison, Robert; Mutabingwa, Theonest K.; Fried, Michal; Duffy, Patrick E.] Seattle Biomed Res Inst, Mother Offspring Malaria Studies Project, Washington, DC USA.
[Gwamaka, Moses; Sorensen, Bess E.; Morrison, Robert; Mutabingwa, Theonest K.; Fried, Michal; Duffy, Patrick E.] Muheza Designated Dist Hosp, Muheza, Tanzania.
[Gwamaka, Moses] Sokoine Univ Agr, Morogoro, Tanzania.
[Kurtis, Jonathan D.] Rhode Isl Hosp, Ctr Int Hlth Res, Providence, RI USA.
[Kurtis, Jonathan D.] Brown Univ, Sch Med, Dept Pathol & Lab Med, Providence, RI 02912 USA.
[Holte, Sarah] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Mutabingwa, Theonest K.] Natl Inst Med Res, Dar Es Salaam, Tanzania.
[Fried, Michal] Univ Washington, Seattle, WA 98195 USA.
RP Duffy, PE (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, NIH, 5640 Fishers Ln,Twinbrook Bldg,Rm 1111, Rockville, MD 20852 USA.
EM patrick.duffy@nih.gov
FU US National Institutes of Health [AI52059]; Bill & Melinda Gates
Foundation [1364]; Seattle BioMed
FX This work was supported by grants from the US National Institutes of
Health (grant AI52059) and the Bill & Melinda Gates Foundation (grant
1364; to P. E. D.). S. H. received grant support from Seattle BioMed.
NR 43
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U1 0
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2012
VL 54
IS 8
BP 1137
EP 1144
DI 10.1093/cid/cis010
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 915EW
UT WOS:000302007900019
PM 22354919
ER
PT J
AU La Rosa, C
Longmate, J
Lacey, SF
Kaltcheva, T
Sharan, R
Marsano, D
Kwon, P
Drake, J
Williams, B
Denison, S
Broyer, S
Couture, L
Nakamura, R
Kelsey, MI
Krieg, AM
Diamond, DJ
Zaia, JA
AF La Rosa, Corinna
Longmate, Jeff
Lacey, Simon F.
Kaltcheva, Teodora
Sharan, Rahul
Marsano, Denise
Kwon, Peter
Drake, Jennifer
Williams, Brenda
Denison, Sharon
Broyer, Suenell
Couture, Larry
Nakamura, Ryotaro
Kelsey, Morris I.
Krieg, Arthur M.
Diamond, Don J.
Zaia, John A.
TI Clinical Evaluation of Safety and Immunogenicity of
PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With
or Without PF03512676 Adjuvant
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID STEM-CELL TRANSPLANTATION; T-CELLS; IMMUNE-RESPONSES; CPG DNA;
TRANSGENIC MICE; INFECTION; RECONSTITUTION; RECIPIENTS; EPITOPES;
DISEASE
AB Background. It has been reported that cytomegalovirus (CMV) pp65-specific T cells can protect hematopoietic cell transplant (HCT) recipients from CMV complications. Two candidate CMV peptide vaccines composed of the HLA A*0201 pp65495-503 cytotoxic CD8(+) T-cell epitope fused to 2 different universal T-helper epitopes (either the synthetic Pan DR epitope [PADRE] or a natural Tetanus sequence) were clinically evaluated for safety and ability to elicit pp65 T cells in HLA A*0201 healthy volunteers.
Methods. Escalating doses (0.5, 2.5, 10 mg) of PADRE or Tetanus pp65(495-503) vaccines with (30 adults) or without (28 adults) PF03512676 adjuvant were administered by subcutaneous injection every 3 weeks for a total of 4 injections.
Results. No serious adverse events were reported, although vaccines used in combination with PF03512676 had enhanced reactogenicity. Ex vivo responses were detected by flow cytometry exclusively in volunteers who received the vaccine coadministered with PF03512676. In addition, using a sensitive in vitro stimulation system, vaccine-elicited pp65(495-503) T cells were expanded in 30% of volunteers injected solely with the CMV peptides and in all tested subjects receiving the vaccines coinjected with PF03512676.
Conclusions. Acceptable safety profiles and vaccine-driven expansion of pp65(495-503) T cells in healthy adults support further evaluation of CMV peptide vaccines combined with PF03512676 in the HCT setting.
Clinical Trials Registration. NCT00722839.
C1 [La Rosa, Corinna; Lacey, Simon F.; Kaltcheva, Teodora; Sharan, Rahul; Marsano, Denise; Kwon, Peter; Diamond, Don J.] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Div Translat Vaccine Res, Dept Virol, Duarte, CA 91010 USA.
[Longmate, Jeff] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Div Biostat, Dept Informat Sci, Duarte, CA 91010 USA.
[Drake, Jennifer; Williams, Brenda] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Gen Clin Res Ctr, Duarte, CA 91010 USA.
[Denison, Sharon] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Dept Inpatient Pharm, Duarte, CA 91010 USA.
[Broyer, Suenell; Couture, Larry] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Ctr Appl Technol Dev, Duarte, CA 91010 USA.
[Nakamura, Ryotaro] City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Dept Hematol & Hematopoiet Cell Transplant, Duarte, CA 91010 USA.
[Kelsey, Morris I.] NCI, Dev Therapeut Program, Rapid Access Intervent Dev Program, Frederick, MD 21701 USA.
[Krieg, Arthur M.] Atlas Venture, Cambridge, MA USA.
RP Diamond, DJ (reprint author), City Hope Comprehens Canc Ctr, Beckman Res Inst City Hope, Div Translat Vaccine Res, Dept Virol, Duarte, CA 91010 USA.
EM ddiamond@coh.org
OI Longmate, Jeffrey/0000-0002-0869-7928; Diamond, Don/0000-0003-3579-7083
FU NIH, National Cancer Institute [R01-CA77544, P01-CA30206, 24XS044];
NCI-RAID, Division of Cancer Treatment and Diagnosis, National Cancer
Institute; National Institute of Allergy and Infectious Diseases [R21
AI084019]; National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) [R21 DK077374]; NCI [CA33572]; National Center for
Research Resources, GCRC; satellite of University of Southern California
GCRC [MO1-RR0043-38]; Edwin and Bea Wolfe Charitable Foundation
FX This work was supported in part by NIH grants from the following
institutes: National Cancer Institute (R01-CA77544 and P01-CA30206,
Project III to D. J. D. and contract 24XS044); and also supported in
part through the NCI-RAID Program of the Developmental Therapeutics
Program, Division of Cancer Treatment and Diagnosis, National Cancer
Institute; National Institute of Allergy and Infectious Diseases (R21
AI084019 to C. L. R.); National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK); R21 DK077374 to S. F. L.); NCI (CA33572 to the
COH Comprehensive Cancer Center); National Center for Research Resources
(MO1-RR0043-38 to COH General Clinical Research Center [GCRC; satellite
of University of Southern California GCRC]); and the Edwin and Bea Wolfe
Charitable Foundation to the Division of Translational Vaccine Research.
NR 50
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U1 2
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD APR 15
PY 2012
VL 205
IS 8
BP 1294
EP 1304
DI 10.1093/infdis/jis107
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 914VL
UT WOS:000301980800017
PM 22402037
ER
PT J
AU Abaan, OD
Davis, SR
Bilke, S
Polley, EC
Walker, RL
Pineda, M
Zhu, YLJ
Reinhold, W
Holbeck, SL
Simon, RM
Doroshow, JH
Pommier, Y
Meltzer, PS
AF Abaan, Ogan D.
Davis, Sean R.
Bilke, Sven
Polley, Eric C.
Walker, Robert L.
Pineda, Marbin
Zhu, Yuelin J.
Reinhold, William
Holbeck, Susan L.
Simon, Richard M.
Doroshow, James H.
Pommier, Yves
Meltzer, Paul S.
TI The exomes of the NCI60 and their implications for cancer
pharmacogenomics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Abaan, Ogan D.; Davis, Sean R.; Bilke, Sven; Polley, Eric C.; Walker, Robert L.; Pineda, Marbin; Zhu, Yuelin J.; Reinhold, William; Holbeck, Susan L.; Simon, Richard M.; Doroshow, James H.; Pommier, Yves; Meltzer, Paul S.] NCI, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1879
DI 10.1158/1538-7445.AM2012-1879
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501043
ER
PT J
AU Abbotts, RM
Sultana, R
Seedhouse, C
Patel, PM
Wilson, DM
Madhusudan, S
AF Abbotts, Rachel M.
Sultana, Rebeka
Seedhouse, Claire
Patel, Poulam M.
Wilson, David M.
Madhusudan, Srinivasan
TI Synthetic lethal targeting of PTEN-associated homologous recombination
(HR) deficient melanoma cells by human apurinic/apyrimidinic
endonuclease (APE1) inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Abbotts, Rachel M.; Sultana, Rebeka; Seedhouse, Claire; Patel, Poulam M.; Madhusudan, Srinivasan] Univ Nottingham, Nottingham NG7 2RD, England.
[Wilson, David M.] NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-263
DI 10.1158/1538-7445.AM2012-LB-263
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602410
ER
PT J
AU Achyut, B
Bader, DA
Pang, YL
Harris, CC
Yang, L
AF Achyut, B.
Bader, David A.
Pang, Yanli
Harris, Curtis C.
Yang, Li
TI Abrogation of stromal TGF-beta signaling induces DNA damage and
genetic/epigenetic alterations in neighboring epithelia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Achyut, B.; Bader, David A.; Pang, Yanli; Harris, Curtis C.; Yang, Li] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 50
DI 10.1158/1538-7445.AM2012-50
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604437
ER
PT J
AU Adhikari, AS
Sullivan, T
Van Dyke, T
AF Adhikari, Amit S.
Sullivan, Teresa
Van Dyke, Terry
TI Astrocytoma initiation by Rb family inactivation induced
dedifferentiation of mature astrocytes.
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Adhikari, Amit S.; Sullivan, Teresa; Van Dyke, Terry] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3346
DI 10.1158/1538-7445.AM2012-3346
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505102
ER
PT J
AU Adiseshaiah, PP
Stern, ST
Patel, NL
Ileva, LV
Kalen, JD
Haines, DC
McNeil, SE
AF Adiseshaiah, Pavan P.
Stern, Stephan T.
Patel, Nimit L.
Ileva, Lilia V.
Kalen, Joseph D.
Haines, Diana C.
McNeil, Scott E.
TI Longitudinal imaging of melanoma cancer cell metastasis in a preclinical
model by bioluminescence, PET/CT, and MRI
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Adiseshaiah, Pavan P.; Stern, Stephan T.; Patel, Nimit L.; Ileva, Lilia V.; Kalen, Joseph D.; Haines, Diana C.; McNeil, Scott E.] NCI, SAIC Inc, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-510
DI 10.1158/1538-7445.AM2012-LB-510
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504207
ER
PT J
AU Alexander, VM
Sano, K
Yu, ZQ
Nakajima, T
Choyke, PL
Ptaszek, M
Kobayashi, H
AF Alexander, Vinita M.
Sano, Kohei
Yu, Zhanqian
Nakajima, Takahito
Choyke, Peter L.
Ptaszek, Marcin
Kobayashi, Hisataka
TI A GSA-NMP1 conjugate: An NIR-activatable fluorescence imaging agent to
detect peritoneal ovarian cancer metastases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Alexander, Vinita M.; Sano, Kohei; Nakajima, Takahito; Choyke, Peter L.; Kobayashi, Hisataka] NCI, CCR, Bethesda, MD 20892 USA.
[Yu, Zhanqian; Ptaszek, Marcin] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-508
DI 10.1158/1538-7445.AM2012-LB-508
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504204
ER
PT J
AU Alimova, IN
Venkataraman, S
Harris, P
Marquez, VE
Birks, D
Foreman, NK
Vibhakar, R
AF Alimova, Irina N.
Venkataraman, Sujatha
Harris, Peter
Marquez, Victor E.
Birks, Diane
Foreman, Nicholas K.
Vibhakar, Rajeev
TI Inhibition of the polycomb group gene EZH2 suppresses growth and
radiosensitizes ATRT cells by promoting senescence and inhibiting the
CycinD-E2F1 axis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Alimova, Irina N.; Venkataraman, Sujatha; Harris, Peter; Birks, Diane; Foreman, Nicholas K.; Vibhakar, Rajeev] Univ Colorado Denver, Aurora, CO USA.
[Marquez, Victor E.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2483
DI 10.1158/1538-7445.AM2012-2483
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501478
ER
PT J
AU Alley, MC
Burkett, MW
Hite, KM
Mertins, SD
Niederhuber, JE
Shoemaker, RH
AF Alley, Michael C.
Burkett, Mark W.
Hite, Karen M.
Mertins, Susan D.
Niederhuber, John E.
Shoemaker, Robert H.
TI Adaptation of soft agar colony formation assays to identify agents which
block proliferation of putative colon cancer stem cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Alley, Michael C.; Mertins, Susan D.; Shoemaker, Robert H.] NCI, Dev Therapeut Program, Frederick, MD 21701 USA.
[Burkett, Mark W.; Hite, Karen M.] NCI, SAIC Inc, Frederick, MD 21701 USA.
[Niederhuber, John E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3379
DI 10.1158/1538-7445.AM2012-3379
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505347
ER
PT J
AU Andersen, JB
Gillen, M
Conner, EA
Factor, VM
Thorgeirsson, SS
AF Andersen, Jesper Boeje
Gillen, Matthew
Conner, Elisabeth A.
Factor, Valentina M.
Thorgeirsson, Snorri S.
TI Translational genomics analyses of cholangiocarcinoma identify patients
who may respond to tyrosine kinase inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Andersen, Jesper Boeje; Gillen, Matthew; Conner, Elisabeth A.; Factor, Valentina M.; Thorgeirsson, Snorri S.] NCI, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4927
DI 10.1158/1538-7445.AM2012-4927
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604269
ER
PT J
AU Antony, S
Wu, YZ
Jiang, GJ
Juhasz, A
Lu, JM
Liu, H
Roy, KK
Doroshow, JH
AF Antony, Smitha
Wu, Yongzhong
Jiang, Guojian
Juhasz, Agnes
Lu, Jiamo
Liu, Han
Roy, Krishnendu K.
Doroshow, James H.
TI NADPH oxidase NOX5 regulates the expression of the cell cycle inhibitor
p27kip1 in the human melanoma UACC-257 cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Antony, Smitha; Wu, Yongzhong; Jiang, Guojian; Juhasz, Agnes; Lu, Jiamo; Liu, Han; Roy, Krishnendu K.; Doroshow, James H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2060
DI 10.1158/1538-7445.AM2012-2060
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604451
ER
PT J
AU Aparicio, M
Amornphimoltham, P
Weigert, R
Lewis, J
Zudaire, E
AF Aparicio, Marta
Amornphimoltham, Panomwat
Weigert, Roberto
Lewis, John
Zudaire, Enrique
TI Rapid discovery of novel antiangiogenic drugs using a phenotypic
profiling platform with high predictive value for preclinical models of
cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Aparicio, Marta; Zudaire, Enrique] NCI, NIH, Bethesda, MD 20892 USA.
[Amornphimoltham, Panomwat; Weigert, Roberto] NIDCR, NIH, Bethesda, MD USA.
[Lewis, John] London Reg Canc Program, Translat Prostate Canc Res Grp, London, ON, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2322
DI 10.1158/1538-7445.AM2012-2322
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504272
ER
PT J
AU Archer, TK
Trotter, KW
Singh, A
AF Archer, Trevor K.
Trotter, Kevin W.
Singh, Ajeet
TI Chromatin remodeling proteins in transcription and development
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Archer, Trevor K.; Trotter, Kevin W.; Singh, Ajeet] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA SY21-01
DI 10.1158/1538-7445.AM2012-SY21-01
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501081
ER
PT J
AU Arem, H
Bobe, G
Sampson, J
Subar, AF
Park, Y
Risch, H
Hollenbeck, AR
Mayne, ST
Stolzenberg-Solomon, R
AF Arem, Hannah
Bobe, Gerd
Sampson, Joshua
Subar, Amy F.
Park, Yikyung
Risch, Harvey
Hollenbeck, Albert R.
Mayne, Susan T.
Stolzenberg-Solomon, Rachael
TI Flavonoid intake and risk of pancreatic cancer in the National
Institutes of Health-AARP Diet and Health Study Cohort
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Arem, Hannah] Yale Univ, NCI, Bethesda, MD USA.
[Bobe, Gerd] Oregon State Univ, Corvallis, OR 97331 USA.
[Sampson, Joshua; Subar, Amy F.; Park, Yikyung; Stolzenberg-Solomon, Rachael] NCI, Bethesda, MD 20892 USA.
[Risch, Harvey; Mayne, Susan T.] Yale Univ, New Haven, CT USA.
[Hollenbeck, Albert R.] AARP, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 625
DI 10.1158/1538-7445.AM2012-625
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602080
ER
PT J
AU Ashktorab, H
Rahi, H
Tbaishat, R
Daremipouran, M
Smoot, DT
Lee, EL
Varma, S
Sun, XG
Jia, XY
Chung, H
Bacon, E
Leavitt, R
Siegel, P
Brim, H
AF Ashktorab, Hassan
Rahi, Hamed
Tbaishat, Rana
Daremipouran, Mohammad
Smoot, Duane T.
Lee, Edward L.
Varma, Sudhir
Sun, Xueguang
Jia, Xi-Yu
Chung, Hunter
Bacon, Eliza
Leavitt, Ron
Siegel, Peter
Brim, Hassan
TI Colorectal cancer, adenoma and normal whole genome methylation
sequencing in Africa Americans
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ashktorab, Hassan; Rahi, Hamed; Tbaishat, Rana; Daremipouran, Mohammad; Smoot, Duane T.; Lee, Edward L.; Brim, Hassan] Howard Univ, Washington, DC 20059 USA.
[Varma, Sudhir] NIH, Bethesda, MD 20892 USA.
[Sun, Xueguang; Jia, Xi-Yu; Chung, Hunter; Bacon, Eliza; Leavitt, Ron] Zymo Res Corp, Riverside, CA USA.
[Siegel, Peter] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 994
DI 10.1158/1538-7445.AM2012-994
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501114
ER
PT J
AU Baas, CL
Samson, S
AF Baas, Carole L.
Samson, Susan
TI Advocacy within the PS-OC: Evolution of the program
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Baas, Carole L.] NCI, Irving, TX USA.
[Samson, Susan] UCSF, San Francisco, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-58
DI 10.1158/1538-7445.AM2011-LB-58
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600148
ER
PT J
AU Bahr, JC
Robey, R
Chakraborty, A
Luchenko, V
Bates, SE
AF Bahr, Julian C.
Robey, Robert
Chakraborty, Arup
Luchenko, Victoria
Bates, Susan E.
TI Short-term romidepsin treatment combined with mitogen-activated protein
kinase and phosphatidylinositol 3-kinase inhibition causes increased Bim
expression and cell death in KRAS mutant cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Bahr, Julian C.; Robey, Robert; Chakraborty, Arup; Luchenko, Victoria; Bates, Susan E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4708
DI 10.1158/1538-7445.AM2012-4708
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603338
ER
PT J
AU Banerjee, AA
Shen, H
Hautman, M
Anwer, J
Kapetanovic, IM
Liu, Y
Lyubimov, AV
AF Banerjee, Aryamitra A.
Shen, Hao
Hautman, Mathew
Anwer, Jaseem
Kapetanovic, Izet M.
Liu, Ying
Lyubimov, Alexander V.
TI Polymeric nanoparticles enhance the bioavailability of the
chemopreventive compound SR13668 in beagle dogs
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Banerjee, Aryamitra A.; Shen, Hao; Liu, Ying; Lyubimov, Alexander V.] Univ Illinois, Chicago, IL USA.
[Hautman, Mathew; Anwer, Jaseem] Ctr Biomed Testing, Chicago, IL USA.
[Kapetanovic, Izet M.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2902
DI 10.1158/1538-7445.AM2012-2902
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600101
ER
PT J
AU Bassig, B
Zhang, LP
Cawthon, R
Yin, SN
Li, GL
Rappaport, S
Hu, W
Smith, MT
Rothman, N
Vermeulen, R
Lan, Q
AF Bassig, Bryan
Zhang, Luoping
Cawthon, Richard
Yin, Songnian
Li, Guilan
Rappaport, Stephen
Hu, Wei
Smith, Martyn T.
Rothman, Nathaniel
Vermeulen, Roel
Lan, Qing
TI Occupational exposure to benzene and leukocyte telomere length
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Bassig, Bryan] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
[Zhang, Luoping; Rappaport, Stephen; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Cawthon, Richard] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
[Yin, Songnian; Li, Guilan] China CDC, Inst Occupat Hlth & Poison Control, Beijing, Peoples R China.
[Hu, Wei; Rothman, Nathaniel; Lan, Qing] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4474
DI 10.1158/1538-7445.AM2012-4474
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603413
ER
PT J
AU Baumbach-Reardon, LL
Gomez, C
Ahearn, ME
Green, A
Ellison, K
Yariz, KO
Issac, B
Clarke, J
Ambs, S
Pegram, M
AF Baumbach-Reardon, Lisa L.
Gomez, Carmen
Ahearn, Mary Ellen
Green, Ashley
Ellison, Kevin
Yariz, Kemal O.
Issac, Biju
Clarke, Jennifer
Ambs, Stefan
Pegram, Mark
TI Identification and investigation of ethnic specific gene expression
differences in non-cancerous breast tissue
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Baumbach-Reardon, Lisa L.] TGEN, Phoenix, AZ USA.
[Gomez, Carmen; Ahearn, Mary Ellen; Green, Ashley; Yariz, Kemal O.; Issac, Biju; Clarke, Jennifer; Pegram, Mark] Univ Miami, Sch Med, Miami, FL USA.
[Ellison, Kevin] Almac Diagnost, Durham, NC USA.
[Ambs, Stefan] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4196
DI 10.1158/1538-7445.AM2012-4196
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502433
ER
PT J
AU Begaye, A
Troste, S
Taylor, RE
Schriemer, DC
Sackett, DL
AF Begaye, Adrian
Troste, Shana
Taylor, Richard E.
Schriemer, David C.
Sackett, Dan L.
TI Localization of the binding site for Peloruside A and Laulimalide on
beta-tubulin by physical and biological means
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Begaye, Adrian; Sackett, Dan L.] NICHD, NIH, Bethesda, MD USA.
[Troste, Shana] NCI, NIH, Bethesda, MD 20892 USA.
[Taylor, Richard E.] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Schriemer, David C.] Univ Calgary, Calgary, AB, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2790
DI 10.1158/1538-7445.AM2012-2790
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603271
ER
PT J
AU Beumer, JH
Holleran, JL
McCormick, DL
Johnson, WD
Covey, JM
Davis, M
Eiseman, JL
AF Beumer, Jan H.
Holleran, Julianne L.
McCormick, David L.
Johnson, William D.
Covey, Joseph M.
Davis, Myrtle
Eiseman, Julie L.
TI Plasma pharmacokinetics of fluorodeoxycytidine, downstream metabolites,
and tetrahydrouridine after combined administration to cynomolgus
monkeys
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Beumer, Jan H.; Holleran, Julianne L.; Eiseman, Julie L.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
[McCormick, David L.; Johnson, William D.] IIT, Res Inst, Chicago, IL 60616 USA.
[Covey, Joseph M.; Davis, Myrtle] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3782
DI 10.1158/1538-7445.AM2012-3782
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501265
ER
PT J
AU Bewry, NN
AF Bewry, Nadine N.
TI Antibody-drug conjugates in oncology drug development: Examining
approaches to set the first-in-human dose
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Bewry, Nadine N.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5391
DI 10.1158/1538-7445.AM2012-5391
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500314
ER
PT J
AU Bilke, S
Schwentner, R
Fan, Y
Kauer, M
Walker, RL
Kovar, H
Melyzer, PS
AF Bilke, Sven
Schwentner, Raphaela
Fan, Yang
Kauer, Max
Walker, Robert L.
Kovar, Heinrich
Melyzer, Paul S.
TI A functional liaison between E2F and aberrant ETS oncogenes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Bilke, Sven; Fan, Yang; Walker, Robert L.; Melyzer, Paul S.] NCI, Bethesda, MD 20892 USA.
[Schwentner, Raphaela; Kauer, Max; Kovar, Heinrich] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1285
DI 10.1158/1538-7445.AM2012-1285
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502388
ER
PT J
AU Blank, M
Zhang, YE
AF Blank, Michael
Zhang, Ying E.
TI Smurf2 is a novel tumor suppressor gene that governs chromatin structure
and genome integrity through RNF20
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Blank, Michael; Zhang, Ying E.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2195
DI 10.1158/1538-7445.AM2012-2195
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606176
ER
PT J
AU Bradley, A
Heselmeyer-Haddad, K
Gaiser, T
Lee, WJ
Schaffer, AA
Andersson, S
Ried, T
AF Bradley, Amanda
Heselmeyer-Haddad, Kerstin
Gaiser, Timo
Lee, Woei-Jyh
Schaffer, Alejandro A.
Andersson, Sonia
Ried, Thomas
TI Clonal patterns of chromosomal aberrations in cervical cancers and
precursor lesions
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Bradley, Amanda; Heselmeyer-Haddad, Kerstin; Gaiser, Timo; Ried, Thomas] NCI, Genet Branch, CCR, NIH, Bethesda, MD 20892 USA.
[Lee, Woei-Jyh; Schaffer, Alejandro A.] NCBI, NIH, Bethesda, MD USA.
[Andersson, Sonia] Karolinska Univ Hosp Solna, Karolinska Inst, Stockholm, Sweden.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2107
DI 10.1158/1538-7445.AM2012-2107
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605235
ER
PT J
AU Buhrow, SA
Kuffel, M
Walden, C
Reid, JM
Covey, J
Ames, MM
AF Buhrow, Sarah A.
Kuffel, Mary
Walden, Chad
Reid, Joel M.
Covey, Joseph
Ames, Matthew M.
TI Metabolic activation of batracylin and N-acetylbatracylin to reactive
metabolites that bind protein and DNA: Possible role in toxicity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Buhrow, Sarah A.; Kuffel, Mary; Walden, Chad; Reid, Joel M.; Ames, Matthew M.] Mayo Clin, Rochester, MN USA.
[Covey, Joseph] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3769
DI 10.1158/1538-7445.AM2012-3769
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501132
ER
PT J
AU Byun, JS
Gardner, K
AF Byun, Jung S.
Gardner, Kevin
TI Reprogramming the cancer epigenome by "metabolic transduction"
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Byun, Jung S.; Gardner, Kevin] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5019
DI 10.1158/1538-7445.AM2012-5019
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605360
ER
PT J
AU Cao, Y
Lindstrom, S
Schumacher, FR
Stevens, VL
Kraft, P
Hsing, AW
Ma, J
AF Cao, Yin
Lindstrom, Sara
Schumacher, Fredrick R.
Stevens, Victoria L.
Kraft, Peter
Hsing, Ann W.
Ma, Jing
CA Breast Prostate Canc Cohort Consor
TI IGF gene pathway and progression to fatal prostate cancer after
diagnosis in men of European ancestry
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Cao, Yin; Lindstrom, Sara] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Schumacher, Fredrick R.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Stevens, Victoria L.] Amer Canc Soc, Lab Serv, Atlanta, GA 30329 USA.
[Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
[Hsing, Ann W.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Ma, Jing] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
[Ma, Jing] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2599
DI 10.1158/1538-7445.AM2012-2599
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602223
ER
PT J
AU Carol, H
Lock, R
Maris, J
Keir, S
Gorlick, R
Kolb, A
Kang, M
Reynolds, P
Wu, JR
Kurmasheva, R
Houghton, P
Smith, M
AF Carol, Hernan
Lock, Richard
Maris, John
Keir, Stephen
Gorlick, Richard
Kolb, Anders
Kang, Min
Reynolds, Patrick
Wu, Jianrong
Kurmasheva, Raushan
Houghton, Peter
Smith, Malcolm
TI Pediatric Preclinical Testing Program (PPTP) evaluation of the JAK
inhibitor AZD1480
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Carol, Hernan; Lock, Richard] Childrens Canc Inst Australia, Randwick, NSW, Australia.
[Maris, John] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Keir, Stephen] Duke Univ, Med Ctr, Durham, NC USA.
[Gorlick, Richard] Montefiore Med Ctr, Bronx, NY 10467 USA.
[Kolb, Anders] Alfred I DuPont Hosp Children, Wilmington, DE USA.
[Kang, Min; Reynolds, Patrick] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
[Wu, Jianrong] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
[Kurmasheva, Raushan; Houghton, Peter] Nationwide Childrens Hosp, Columbus, OH USA.
[Smith, Malcolm] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-318
DI 10.1158/1538-7445.AM2012-LB-318
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504221
ER
PT J
AU Chang, JT
Shebl, FM
Pfeiffer, RM
Graubard, BI
Biryahwaho, B
Dollard, SC
Mbulaiteye, SM
AF Chang, Joanne T.
Shebl, Fatma M.
Pfeiffer, Ruth M.
Graubard, Barry I.
Biryahwaho, Benon
Dollard, Sheila C.
Mbulaiteye, Sam M.
TI Investigating human herpesvirus 8 infection among adults in Uganda: A
factor analysis approach
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Chang, Joanne T.] Univ Michigan, Natl Canc Inst, Ann Arbor, MI 48109 USA.
[Shebl, Fatma M.] Yale Univ, Chron Dis Epidemiol Div, New Haven, CT USA.
[Pfeiffer, Ruth M.; Graubard, Barry I.; Mbulaiteye, Sam M.] NCI, DCEG, Bethesda, MD 20892 USA.
[Biryahwaho, Benon; Dollard, Sheila C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5487
DI 10.1158/1538-7445.AM2012-5487
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602149
ER
PT J
AU Chang, S
Sharan, S
AF Chang, Suhwan
Sharan, Shyam
TI Tumor suppressor BRCA1 epigenetically controls oncogenic miRNA-155
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Chang, Suhwan; Sharan, Shyam] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 142
DI 10.1158/1538-7445.AM2012-142
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503011
ER
PT J
AU Chanock, SJ
AF Chanock, Stephen J.
TI Genome-wide association studies in cancer: A step in the right direction
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Chanock, Stephen J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA SY34-01
DI 10.1158/1538-7445.AM2012-SY34-01
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602200
ER
PT J
AU Charbonneau, B
White, KL
Schildkraut, JM
Palmieri, RT
Iversen, E
Berchuck, A
Vierkant, RA
Rider, DN
Cicek, MS
Sutphen, R
Birrer, MJ
Pharoah, PPD
Song, HL
Tyler, J
Gayther, SA
Ramus, SJ
Wentzensen, N
Yang, HP
Garcia-Closas, M
Phelan, CM
Cunningham, JM
Fridley, BL
Sellers, TA
Goode, EL
AF Charbonneau, Bridget
White, Kristin L.
Schildkraut, Joellen M.
Palmieri, Rachel T.
Iversen, Ed
Berchuck, Andrew
Vierkant, Robert A.
Rider, David N.
Cicek, Mine S.
Sutphen, Rebecca
Birrer, Michael J.
Pharoah, Paul P. D.
Song, Honglin
Tyler, Jonathan
Gayther, Simon A.
Ramus, Susan J.
Wentzensen, Nicolas
Yang, Hannah P.
Garcia-Closas, Montserrat
Phelan, Catherine M.
Cunningham, Julie M.
Fridley, Brooke L.
Sellers, Thomas A.
Goode, Ellen L.
TI Subtype-specific ovarian cancer risk associated with SNPs in IL1A
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Charbonneau, Bridget; Vierkant, Robert A.; Rider, David N.; Cicek, Mine S.; Cunningham, Julie M.; Fridley, Brooke L.; Goode, Ellen L.] Mayo Clin, Coll Med, Rochester, MN USA.
[White, Kristin L.] Columbia Univ, New York, NY USA.
[Schildkraut, Joellen M.; Berchuck, Andrew] Duke Univ, Duke Comprehens Canc Ctr, Durham, NC USA.
[Palmieri, Rachel T.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Iversen, Ed] Duke Univ, Dept Stat Sci, Durham, NC USA.
[Sutphen, Rebecca] Univ S Florida, Coll Med, Tampa, FL USA.
[Birrer, Michael J.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Pharoah, Paul P. D.; Song, Honglin; Tyler, Jonathan] Univ Cambridge, Cambridge, England.
[Gayther, Simon A.; Ramus, Susan J.] Univ So Calif, Los Angeles, CA USA.
[Wentzensen, Nicolas; Yang, Hannah P.] NCI, Bethesda, MD 20892 USA.
[Garcia-Closas, Montserrat] Inst Canc Res, Sutton, Surrey, England.
[Sellers, Thomas A.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2603
DI 10.1158/1538-7445.AM2012-2603
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602227
ER
PT J
AU Choi, BH
Lee, KS
Dai, W
AF Choi, Byeong Hyeok
Lee, Kyung S.
Dai, Wei
TI Phosphorylation and regulation of PTEN by Polo-like kinase 1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Choi, Byeong Hyeok; Dai, Wei] NYU, Dept Environm Med, Langone Med Ctr, Tuxedo Pk, NY USA.
[Lee, Kyung S.] NCI, NIH, Tuxedo Pk, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2048
DI 10.1158/1538-7445.AM2012-2048
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604315
ER
PT J
AU Dahiya, N
Bryant, J
Aprelikova, O
Neiderhuber, J
Jazaeri, AA
AF Dahiya, Neetu
Bryant, Jennifer
Aprelikova, Olga
Neiderhuber, John
Jazaeri, Amir A.
TI Comparison of cisplatin induced changes in serous ovarian cancer and
normal fallopian tube cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Dahiya, Neetu; Bryant, Jennifer; Jazaeri, Amir A.] Univ Virginia, Charlottesville, VA USA.
[Aprelikova, Olga; Neiderhuber, John] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 801
DI 10.1158/1538-7445.AM2012-801
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603053
ER
PT J
AU Daniel, CR
Chow, WH
Park, Y
Graubard, BII
Hollenbeck, AR
Sinha, R
AF Daniel, Carrie R.
Chow, Wong-Ho
Park, Yikyung
Graubard, Barry I. I.
Hollenbeck, Albert R.
Sinha, Rashmi
TI Intake of fiber and fiber-rich plant foods associated with lower risk of
renal cell carcinoma in a large US cohort
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Daniel, Carrie R.; Chow, Wong-Ho; Park, Yikyung; Graubard, Barry I. I.; Sinha, Rashmi] NCI, Rockville, MD USA.
[Hollenbeck, Albert R.] AARP, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 659
DI 10.1158/1538-7445.AM2012-659
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602115
ER
PT J
AU Nguyen, D
Witter, S
Tomaszewski, JE
Ivy, P
Doroshow, JH
Yang, SX
AF Dat Nguyen
Witter, Sara
Tomaszewski, Joseph E.
Ivy, Percy
Doroshow, James H.
Yang, Sherry X.
TI Notch-1 expression in human cancer cell lines and solid tumors by
validated immunohistochemistry
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Dat Nguyen; Witter, Sara; Tomaszewski, Joseph E.; Ivy, Percy; Doroshow, James H.; Yang, Sherry X.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 746
DI 10.1158/1538-7445.AM2012-746
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601319
ER
PT J
AU Davis, M
Conlon, KC
Bohac, G
Barcenas, J
Leslie, WT
Deng, YP
Li, Y
Plate, JMD
AF Davis, Marcherie
Conlon, Kevin C.
Bohac, Gerald
Barcenas, John
Leslie, William T.
Deng, Youping
Li, Yan
Plate, Janet M. D.
TI The effects of pemetrexed on innate and adaptive immune cells in
subjects with adenocarcinoma of the pancreas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Davis, Marcherie; Barcenas, John; Leslie, William T.; Deng, Youping; Li, Yan; Plate, Janet M. D.] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
[Conlon, Kevin C.] NCI, NIH, Bethesda, MD 20892 USA.
[Bohac, Gerald] Amgen Inc, Thousand Oaks, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 527
DI 10.1158/1538-7445.AM2012-527
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500426
ER
PT J
AU De Matteis, S
Consonni, D
Pesatori, AC
Bergen, AW
Bertazzi, PA
Caporaso, NE
Lubin, JH
Wacholder, S
Landi, MT
AF De Matteis, Sara
Consonni, Dario
Pesatori, Angela C.
Bergen, Andrew W.
Bertazzi, Pier Alberto
Caporaso, Neil E.
Lubin, Jay H.
Wacholder, Sholom
Landi, Maria Teresa
TI Tobacco smoking women are not at higher risk than men for lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [De Matteis, Sara; Caporaso, Neil E.; Lubin, Jay H.; Wacholder, Sholom; Landi, Maria Teresa] NIH, Rockville, MD USA.
[Consonni, Dario; Pesatori, Angela C.; Bertazzi, Pier Alberto] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy.
[Consonni, Dario; Pesatori, Angela C.; Bertazzi, Pier Alberto] Univ Milan, Milan, Italy.
[Bergen, Andrew W.] SRI Int, Ctr Hlth Sci, Menlo Pk, CA 94025 USA.
RI Consonni, Dario/K-7943-2016
OI Consonni, Dario/0000-0002-8935-3843
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 630
DI 10.1158/1538-7445.AM2012-630
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602085
ER
PT J
AU De Mukhopadhyay, K
Elkhaloun, AG
Hinck, AP
Yoon, K
Corneil, JE
Yu, L
Liu, Z
Yang, JH
Sun, LZ
AF De Mukhopadhyay, Keya
Elkhaloun, Abdel G.
Hinck, Andrew P.
Yoon, Kihoon
Corneil, John E.
Yu, Lan
Liu, Zhao
Yang, Junhua
Sun, LuZhe
TI Delineating the molecular signature of the breast cancer-induced brain
metastasis and the role of a novel pan-TGF-beta inhibitor to block brain
metastasis in a mouse xenograft model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [De Mukhopadhyay, Keya; Hinck, Andrew P.; Yoon, Kihoon; Corneil, John E.; Yu, Lan; Liu, Zhao; Yang, Junhua; Sun, LuZhe] UT Hlth Sci Ctr, San Antonio, TX USA.
[Elkhaloun, Abdel G.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3390
DI 10.1158/1538-7445.AM2012-3390
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504015
ER
PT J
AU Demchok, JP
Bouchard, B
Vaught, J
Cho, YM
AF Demchok, Joanne P.
Bouchard, Brigitte
Vaught, Jim
Cho, Young-Min
TI An international overview of the "state of the science" of regulatory
standards for human tissue biobanking
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Demchok, Joanne P.; Vaught, Jim; Cho, Young-Min] NIH, Rockville, MD USA.
[Bouchard, Brigitte] Chargee Mission Direct Gen Rech & Innovat, Paris, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4571
DI 10.1158/1538-7445.AM2012-4571
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601249
ER
PT J
AU Deng, W
Dai, CL
Zhao, XQ
Ohnuma, S
Liang, YJ
Xiao, ZJ
Zeng, MS
Ambudkar, SV
Fu, LW
Chen, ZS
AF Deng, Wen
Dai, Chun-Ling
Zhao, Xiao-qin
Ohnuma, Shinobu
Liang, Yong-ju
Xiao, Zhi-Jie
Zeng, Mu-Sheng
Ambudkar, Suresh V.
Fu, Li-wu
Chen, Zhe-Sheng
TI Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting
the function of ATP-binding cassette subfamily G member 2
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Deng, Wen; Dai, Chun-Ling; Xiao, Zhi-Jie; Chen, Zhe-Sheng] St Johns Univ, Coll Pharm & Allied Hlth Profess, Queens, NY USA.
[Zhao, Xiao-qin; Liang, Yong-ju; Zeng, Mu-Sheng; Fu, Li-wu] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.
[Ohnuma, Shinobu; Ambudkar, Suresh V.] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5614
DI 10.1158/1538-7445.AM2012-5614
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603244
ER
PT J
AU Du, JH
Romano, RA
Yang, XP
Si, H
Bian, YS
Sinha, S
Van Waes, C
Chen, Z
AF Du, Jihui
Romano, Rose-Anne
Yang, Xinping
Si, Han
Bian, Yansong
Sinha, Satrajit
Van Waes, Carter
Chen, Zhong
TI DeltaNp63 overexpression induced cytokines and chemokines attract type2
suppressive inflammatory infiltrates through NF-kappaB activation in
dysplastic and malignant epithelia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Du, Jihui; Yang, Xinping; Si, Han; Bian, Yansong; Van Waes, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
[Romano, Rose-Anne; Sinha, Satrajit] SUNY Buffalo, Buffalo, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3549
DI 10.1158/1538-7445.AM2011-3549
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500457
ER
PT J
AU Dworkin, AM
Lee, M
Lichtenberg, J
Gildea, D
Triyedi, N
Wolfsberg, T
Crawford, NP
AF Dworkin, Amy M.
Lee, Minnkyong
Lichtenberg, Jens
Gildea, Derek
Triyedi, Niraj
Wolfsberg, Tyra
Crawford, Nigel P.
TI A survival-associated polymorphism within metastasis suppressor RRP1B
directs RRP1B-chromatin interactions and self-regulation of gene
expression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Dworkin, Amy M.; Lee, Minnkyong; Lichtenberg, Jens; Gildea, Derek; Triyedi, Niraj; Wolfsberg, Tyra; Crawford, Nigel P.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3420
DI 10.1158/1538-7445.AM2012-3420
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504048
ER
PT J
AU Etemadi, A
Islami, F
van Schooten, FJ
Phillips, DH
Godschalk, R
Golozar, A
Kamangar, F
Fazel-Tabar, A
Pourshams, A
Boffetta, P
Abnet, CC
Malekzadeh, R
Dawsey, SM
AF Etemadi, Arash
Islami, Farhad
van Schooten, Frederik-Jan
Phillips, David H.
Godschalk, Roger
Golozar, Asieh
Kamangar, Farin
Fazel-Tabar, Akbar
Pourshams, Akram
Boffetta, Paolo
Abnet, Christian C.
Malekzadeh, Reza
Dawsey, Sanford M.
TI Genetic determinants of PAH-DNA adduct level and nucleotide excision
repair among non-smokers in a high risk area for esophageal squamous
cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Etemadi, Arash; Golozar, Asieh; Abnet, Christian C.; Dawsey, Sanford M.] NCI, Bethesda, MD 20892 USA.
[Islami, Farhad] Int Agcy Res Canc, F-69372 Lyon, France.
[van Schooten, Frederik-Jan; Godschalk, Roger] Maastricht Univ, NL-6200 MD Maastricht, Netherlands.
[Phillips, David H.] Inst Canc Res, Sutton, Surrey, England.
[Kamangar, Farin] Morgan State Univ, Baltimore, MD 21239 USA.
[Fazel-Tabar, Akbar; Pourshams, Akram; Malekzadeh, Reza] Univ Tehran Med Sci, Tehran, Iran.
[Boffetta, Paolo] Mt Sinai Sch Med, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2646
DI 10.1158/1538-7445.AM2012-2646
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602275
ER
PT J
AU Fallon, JK
Tighe, R
Strittmatter, W
Sabzevari, H
Schlom, J
Greiner, JW
AF Fallon, Jonathan K.
Tighe, Robert
Strittmatter, Wolfgang
Sabzevari, Helen
Schlom, Jeffrey
Greiner, John W.
TI A novel immunocytokine generates a CD8+T cell-mediated anti-tumor
response in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Fallon, Jonathan K.; Schlom, Jeffrey; Greiner, John W.] NCI, LTIB, Bethesda, MD 20892 USA.
[Tighe, Robert; Strittmatter, Wolfgang; Sabzevari, Helen] EMD Serono, Billerica, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1536
DI 10.1158/1538-7445.AM2012-1536
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500317
ER
PT J
AU Fang, J
AF Fang, Jun
TI The processed pseudogene POU5F1P1 in 8q24 is expressed in tumor and
shows oncogenicity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Fang, Jun] NCI, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 117
DI 10.1158/1538-7445.AM2012-117
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605392
ER
PT J
AU Fei, C
DeRoo, LA
Sandler, DP
Weinberg, CR
AF Fei, Chunyuan
DeRoo, Lisa A.
Sandler, Dale P.
Weinberg, Clarice R.
TI Menopause-associated symptoms, HRT use and risk of young-onset breast
cancer: Results from the Two Sister Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Fei, Chunyuan; DeRoo, Lisa A.; Sandler, Dale P.; Weinberg, Clarice R.] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5493
DI 10.1158/1538-7445.AM2012-5493
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602155
ER
PT J
AU Feigelson, HS
Bischoff, K
Ravel, J
Gail, MH
Flores, R
Goedert, JJ
AF Feigelson, Heather Spencer
Bischoff, Kimberly
Ravel, Jacques
Gail, Mrtchell H.
Flores, Roberto
Goedert, James J.
TI Feasibility study of gut microbiome collection in randomly sampled women
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Feigelson, Heather Spencer; Bischoff, Kimberly] Kaiser Permanente, Denver, CO USA.
[Ravel, Jacques] Univ Maryland, Baltimore, MD 21201 USA.
[Gail, Mrtchell H.; Flores, Roberto; Goedert, James J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5489
DI 10.1158/1538-7445.AM2012-5489
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602151
ER
PT J
AU Figueroa, JD
Linville, L
Brinton, LA
Patel, D
Clare, SE
Visscher, D
Mies, C
Pfeiffer, RM
Gierach, GL
Yang, R
Hewitt, S
Storniolo, AM
Sherman, ME
AF Figueroa, Jonine D.
Linville, Laura
Brinton, Louise A.
Patel, Deesha
Clare, Susan E.
Visscher, Daniel
Mies, Carrolyn
Pfeiffer, Ruth M.
Gierach, Gretchen L.
Yang, Rose
Hewitt, Stephen
Storniolo, Anna Maria
Sherman, Mark E.
TI Breast cancer risk factor associations with breast tissue morphometry:
results from the Komen for the Cure (R) Tissue Bank
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Figueroa, Jonine D.; Linville, Laura; Brinton, Louise A.; Patel, Deesha; Pfeiffer, Ruth M.; Gierach, Gretchen L.; Yang, Rose] NCI, DCEG, Bethesda, MD 20892 USA.
[Clare, Susan E.; Storniolo, Anna Maria] Indiana Univ, Simon Canc Ctr, Susan G Komen Cure Tissue Bank, Indianapolis, IN 46204 USA.
[Visscher, Daniel] Mayo Clin, Ctr Canc, Rochester, MN USA.
[Mies, Carrolyn] Univ Penn, Philadelphia, PA 19104 USA.
[Hewitt, Stephen; Sherman, Mark E.] NCI, Appl Mol Pathol Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4465
DI 10.1158/1538-7445.AM2012-4465
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603313
ER
PT J
AU Fleming, JL
Dworkin, AM
Zhang, M
Qureshi, AA
Allain, DC
Fernandez, S
Wei, L
Peters, S
Iwenofu, OH
Ridd, K
Bastian, BC
Han, JL
Toland, AE
AF Fleming, Jessica L.
Dworkin, Amy M.
Zhang, Mingfeng
Qureshi, Abrar A.
Allain, Dawn C.
Fernandez, Soledad
Wei, Lai
Peters, Sara
Iwenofu, O. Hans
Ridd, Katie
Bastian, Boris C.
Han, Jiali
Toland, Amanda E.
TI Allelic-specific imbalance mapping identifies HDAC9 as a candidate
susceptibility gene for cutaneous squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Fleming, Jessica L.; Allain, Dawn C.; Fernandez, Soledad; Wei, Lai; Peters, Sara; Iwenofu, O. Hans; Toland, Amanda E.] Ohio State Univ, Columbus, OH 43210 USA.
[Dworkin, Amy M.] NIH, Bethesda, MD 20892 USA.
[Zhang, Mingfeng; Qureshi, Abrar A.; Han, Jiali] Harvard Univ, Cambridge, MA 02138 USA.
[Ridd, Katie; Bastian, Boris C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4857
DI 10.1158/1538-7445.AM2012-4857
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501122
ER
PT J
AU Francis, P
Moon, SY
Bilke, S
Zhu, YLJ
Walker, RL
Pineda, M
Li, XL
Abaan, O
Knight, J
Davis, S
Turner, J
Wang, H
Bruhn, L
Lai, A
Meltzer, PS
AF Francis, Princy
Moon, So Young
Bilke, Sven
Zhu, Yuelin J.
Walker, Robert L.
Pineda, Marbin
Li, Xiao Ling
Abaan, Ogan
Knight, Jeffrey
Davis, Sean
Turner, Jaleisa
Wang, Hui
Bruhn, Laurakay
Lai, Ashish
Meltzer, Paul S.
TI Role of the microRNA-23a similar to 27a similar to 24 clusters in
osteosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Francis, Princy; Moon, So Young; Bilke, Sven; Zhu, Yuelin J.; Walker, Robert L.; Pineda, Marbin; Li, Xiao Ling; Abaan, Ogan; Knight, Jeffrey; Davis, Sean; Turner, Jaleisa; Lai, Ashish; Meltzer, Paul S.] NCI, NIH, Bethesda, MD 20892 USA.
[Wang, Hui; Bruhn, Laurakay] Agilent Technol, Agilent Labs, Santa Clara, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1113
DI 10.1158/1538-7445.AM2012-1113
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503037
ER
PT J
AU Freeman, AK
Ritt, DA
Morrison, DK
AF Freeman, Alyson K.
Ritt, Daniel A.
Morrison, Deborah K.
TI Differential effects of dimerization on B-Raf and C-Raf function
revealed by mutational analysis and peptide inhibitors that target the
Raf dimer interface
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Freeman, Alyson K.; Ritt, Daniel A.; Morrison, Deborah K.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1239
DI 10.1158/1538-7445.AM2012-1239
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502226
ER
PT J
AU Fung, KL
Tepede, AK
Pluchino, KM
Hall, MD
Gottesman, MM
AF Fung, King Leung
Tepede, Abisola K.
Pluchino, Kristen M.
Hall, Matthew D.
Gottesman, Michael M.
TI Influx of thiosemicarbazone NSC73306 is mediated by the cisplatin and
copper transporter SLC31A1 (CTR1)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Fung, King Leung; Tepede, Abisola K.; Pluchino, Kristen M.; Hall, Matthew D.; Gottesman, Michael M.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 843
DI 10.1158/1538-7445.AM2012-843
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603160
ER
PT J
AU Gadd, SL
Gerhard, DS
Smith, MA
Auvil, JG
Huff, V
Geller, JI
Dome, J
Huang, CC
Perlman, EJ
AF Gadd, Samantha L.
Gerhard, Daniela S.
Smith, Malcom A.
Auvil, Jaime Guidry
Huff, Vicki
Geller, James I.
Dome, Jeffrey
Huang, Chiang-Ching
Perlman, Elizabeth J.
TI Loss of expression of SWI/SNF subunits in high risk Wilms tumor is
accompanied by global gene expression changes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gadd, Samantha L.; Huang, Chiang-Ching; Perlman, Elizabeth J.] Northwestern Univ, Chicago, IL 60611 USA.
[Gerhard, Daniela S.; Smith, Malcom A.; Auvil, Jaime Guidry] NCI, Bethesda, MD 20892 USA.
[Huff, Vicki] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Geller, James I.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
[Dome, Jeffrey] Childrens Natl Med Ctr, Washington, DC 20010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1439
DI 10.1158/1538-7445.AM2012-1439
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501460
ER
PT J
AU Gangjee, A
Pavana, RK
Zhang, X
Ihnat, M
Hamel, E
AF Gangjee, Aleem
Pavana, Roheeth Kumar
Zhang, Xin
Ihnat, Michael
Hamel, Ernest
TI Design and preclinical evaluation of single agents with antitubulin and
antiangiogenic activity as antitumor agents
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gangjee, Aleem; Pavana, Roheeth Kumar; Zhang, Xin] Duquesne Univ, Pittsburgh, PA 15219 USA.
[Ihnat, Michael] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
[Hamel, Ernest] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3897
DI 10.1158/1538-7445.AM2012-3897
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601476
ER
PT J
AU Gangjee, A
Lin, L
Mooberry, SL
Hamel, E
AF Gangjee, Aleem
Lin, Lu
Mooberry, Susan L.
Hamel, Ernest
TI Substituted pyrrolo[2,3-d]pyrimidines as water soluble microtubule
targeting agents
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gangjee, Aleem; Lin, Lu] Duquesne Univ, Grad Sch Pharmaceut Sci, Pittsburgh, PA 15219 USA.
[Mooberry, Susan L.] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA.
[Hamel, Ernest] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3889
DI 10.1158/1538-7445.AM2012-3889
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601387
ER
PT J
AU Gao, L
Duan, WR
Wu, X
Chen, A
Otterson, GA
Villalona, MA
AF Gao, Li
Duan, Wenrui
Wu, Xin
Chen, Alice
Otterson, Gregory A.
Villalona, Miguel A.
TI Compensatory activation of alternative DNA repair pathways following
exposure to the PARP Inhibitor ABT-888 in vitro and in patients with
solid malignancies
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gao, Li; Duan, Wenrui; Wu, Xin; Otterson, Gregory A.; Villalona, Miguel A.] Ohio State Univ, Columbus, OH 43210 USA.
[Chen, Alice] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4682
DI 10.1158/1538-7445.AM2012-4682
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603078
ER
PT J
AU Gao, Y
Caporaso, N
AF Gao, Ying
Caporaso, Neil
TI Gene-specific methylation of leukocyte DNA in relation to colorectal
cancer among male smokers from a nested case-control study in the ATBC
Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gao, Ying; Caporaso, Neil] NCI, DCEG, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4467
DI 10.1158/1538-7445.AM2012-4467
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603335
ER
PT J
AU Garcia-Closas, M
Rothman, N
Figueroa, JD
Prokunina-Olsson, L
Han, S
Baris, D
Jacobs, E
Malats, N
De Vivo, I
Albanes, D
Purdue, MP
Sharma, S
Fu, YP
Kogevinas, M
Wang, Z
Tang, W
Tardon, A
Serra, C
Carrato, A
Garcia-Closas, R
Lloreta, J
Johnson, A
Schwenn, M
Karagas, MR
Schned, A
Andriole, G
Grubb, R
Black, A
Gapstur, SM
Thun, M
Diver, WR
Weinstein, SJ
Virtamo, J
Hunter, DJ
Caporaso, N
Landi, MT
Hutchinson, A
Burdett, L
Jacobs, KB
Yeager, M
Fraumeni, JF
Chanock, SJ
Silverman, DT
Chatterjee, N
AF Garcia-Closas, M.
Rothman, N.
Figueroa, J. D.
Prokunina-Olsson, L.
Han, S.
Baris, D.
Jacobs, E.
Malats, N.
De Vivo, I.
Albanes, D.
Purdue, M. P.
Sharma, S.
Fu, Y. P.
Kogevinas, M.
Wang, Z.
Tang, W.
Tardon, A.
Serra, C.
Carrato, A.
Garcia-Closas, R.
Lloreta, J.
Johnson, A.
Schwenn, M.
Karagas, M. R.
Schned, A.
Andriole, G.
Grubb, R.
Black, A.
Gapstur, S. M.
Thun, M.
Diver, W. R.
Weinstein, S. J.
Virtamo, J.
Hunter, D. J.
Caporaso, N.
Landi, M. T.
Hutchinson, A.
Burdett, L.
Jacobs, K. B.
Yeager, M.
Fraumeni, J. F.
Chanock, S. J.
Silverman, D. T.
Chatterjee, N.
TI Synergistic effects of twelve common genetic polymorphisms and smoking
habits on absolute risk of bladder cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Garcia-Closas, M.; Sharma, S.] Inst Canc Res, Sutton, Surrey, England.
[Rothman, N.; Figueroa, J. D.; Prokunina-Olsson, L.; Han, S.; Baris, D.; Albanes, D.; Purdue, M. P.; Fu, Y. P.; Tang, W.; Black, A.; Weinstein, S. J.; Caporaso, N.; Landi, M. T.; Fraumeni, J. F.; Chanock, S. J.; Silverman, D. T.; Chatterjee, N.] NCI, Bethesda, MD 20892 USA.
[Jacobs, E.; Thun, M.; Diver, W. R.] Amer Canc Soc, Atlanta, GA 30329 USA.
[Malats, N.] Spanish Natl Canc Res Ctr, Madrid, Spain.
[De Vivo, I.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Kogevinas, M.] CREAL, Barcelona, Spain.
[Wang, Z.; Hutchinson, A.; Burdett, L.; Jacobs, K. B.; Yeager, M.] NCI, Frederick, MD 21701 USA.
[Tardon, A.] Univ Oviedo, Oviedo, Spain.
[Serra, C.; Lloreta, J.] Univ Pompeu Fabra, Barcelona, Spain.
[Carrato, A.] Ramon y Cajal Univ Hosp, Madrid, Spain.
[Garcia-Closas, R.] Hosp Univ Canarias, San Cristobal la Laguna, Spain.
[Johnson, A.] Vermont Canc Registry, Burlington, VT USA.
[Schwenn, M.] Maine Canc Registy, Augusta, ME USA.
[Karagas, M. R.; Schned, A.] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA.
[Andriole, G.; Grubb, R.] Washington Univ, Sch Med, St Louis, MO USA.
[Gapstur, S. M.] Amer Canc inst, Atlanta, GA USA.
[Virtamo, J.] Natl Inst Hlth & Welf, Helsinki, Finland.
[Hunter, D. J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
RI Kogevinas, Manolis/C-3918-2017
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-337
DI 10.1158/1538-7445.AM2012-LB-337
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603235
ER
PT J
AU Gebregiorgis, M
Woldemichael, G
He, M
Kang, MH
Nunez, LE
Moris, F
Smith, MA
Helman, LJ
Grohar, PJ
AF Gebregiorgis, Meti
Woldemichael, Girma
He, Min
Kang, Min H.
Nunez, Luz E.
Moris, Francisco
Smith, Malcolm A.
Helman, Lee J.
Grohar, Patrick J.
TI Identification of mithramycin analogues with increased potency and more
selective inhibition of EWS-FLI1 for the treatment of Ewing sarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gebregiorgis, Meti; Helman, Lee J.] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.
[Woldemichael, Girma] NCI, Mol Targets Lab, Frederick, MD USA.
[He, Min] NCI, Dev Therapeut Program, Rockville, MD USA.
[Kang, Min H.] Texas Tech Sch Med, Univ Hlth Sci Ctr, Lubbock, TX USA.
[Smith, Malcolm A.] NCI, Clin Invest Branch, Rockville, MD USA.
[Grohar, Patrick J.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2494
DI 10.1158/1538-7445.AM2011-2494
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501490
ER
PT J
AU Gharpure, RV
Mendoza, A
Dennis, JU
Khanna, C
AF Gharpure, Radhika V.
Mendoza, Arnulfo
Dennis, John U.
Khanna, Chand
TI The PAMM (pulmonary assessment of metastatic morbidity) diagnostic: A
novel non-invasive method for evaluating lung metastasis in murine
models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gharpure, Radhika V.; Mendoza, Arnulfo; Khanna, Chand] NCI, Bethesda, MD 20892 USA.
[Dennis, John U.] SAIC Frederick Lab Anim Sci Program, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1365
DI 10.1158/1538-7445.AM2012-1365
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504413
ER
PT J
AU Gibson, TM
Engels, EA
Clarke, CA
Pfeiffer, RM
Lynch, CF
Chang, ET
Hall, E
Weisenburger, DD
Morton, LM
AF Gibson, Todd M.
Engels, Eric A.
Clarke, Christina A.
Pfeiffer, Ruth M.
Lynch, Charles F.
Chang, Ellen T.
Hall, Erin
Weisenburger, Dennis D.
Morton, Lindsay M.
TI Risk of diffuse large B-cell lymphoma in solid organ transplant
recipients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gibson, Todd M.; Engels, Eric A.; Pfeiffer, Ruth M.; Morton, Lindsay M.] NCI, Rockville, MD USA.
[Clarke, Christina A.; Chang, Ellen T.] Canc Prevent Inst Calif, Fremont, CA USA.
[Lynch, Charles F.] Univ Iowa, Iowa City, IA USA.
[Hall, Erin] Johns Hopkins Univ Hosp, Baltimore, MD USA.
[Weisenburger, Dennis D.] Univ Nebraska Med Ctr, Omaha, NE USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1025
DI 10.1158/1538-7445.AM2012-1025
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602367
ER
PT J
AU Godfrey, AC
Xu, ZL
Weinberg, CR
Wade, PA
Deroo, LA
Sandler, DP
Taylor, JA
AF Godfrey, Ashley C.
Xu, Zongli
Weinberg, Clarice R.
Wade, Paul A.
Deroo, Lisa A.
Sandler, Dale P.
Taylor, Jack A.
TI Serum miRNAs as an early marker for breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Godfrey, Ashley C.; Xu, Zongli; Weinberg, Clarice R.; Wade, Paul A.; Deroo, Lisa A.; Sandler, Dale P.; Taylor, Jack A.] NIEHS, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5049
DI 10.1158/1538-7445.AM2012-5049
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503065
ER
PT J
AU Gomes-DaGama, EM
Moulick, K
Ahn, JH
Zong, H
Rodina, A
Cerchietti, L
Lopes-Vazquez, MEC
Beebe, K
Perna, F
Katerina, C
Vu, LP
Zhao, XY
Zatorska, D
Taldone, T
Smith-Jones, P
Alpaugh, M
Grosso, SS
Pillarsetty, N
Ku, T
Lewis, JS
Larson, SM
Ross, L
Erdjument-Bromage, H
Guzman, ML
Nimer, SD
Melnick, AM
Neckers, L
Chiosis, G
AF Gomes-DaGama, Erica M.
Moulick, Kamalika
Ahn, James H.
Zong, Hongliang
Rodina, Anna
Cerchietti, Leandro
Lopes-Vazquez, Maria E. Caldas
Beebe, Kristin
Perna, Fabiana
Katerina, Chatzi
Vu, Ly P.
Zhao, Xinyang
Zatorska, Danuta
Taldone, Tony
Smith-Jones, Peter
Alpaugh, Mary
Grosso, Steven S.
Pillarsetty, Nagavarakishore
Ku, Thomas
Lewis, Jason S.
Larson, Steven M.
Ross, Levine
Erdjument-Bromage, Hediye
Guzman, Monica L.
Nimer, Stephen D.
Melnick, Ari M.
Neckers, Len
Chiosis, Gabriela
TI Affinity-based proteomics reveal cancer-specific networks coordinated by
Hsp90
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gomes-DaGama, Erica M.; Moulick, Kamalika; Ahn, James H.; Rodina, Anna; Lopes-Vazquez, Maria E. Caldas; Perna, Fabiana; Vu, Ly P.; Zhao, Xinyang; Zatorska, Danuta; Taldone, Tony; Smith-Jones, Peter; Alpaugh, Mary; Pillarsetty, Nagavarakishore; Ku, Thomas; Lewis, Jason S.; Larson, Steven M.; Ross, Levine; Erdjument-Bromage, Hediye; Nimer, Stephen D.; Chiosis, Gabriela] Mem Sloan Kettering Canc Ctr, New York, NY USA.
[Zong, Hongliang; Cerchietti, Leandro; Katerina, Chatzi; Guzman, Monica L.; Melnick, Ari M.] Weill Cornell Med Coll, Div Hematol & Oncol, New York, NY USA.
[Beebe, Kristin] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Grosso, Steven S.] Cornell Univ, Weill Med Coll, Ithaca, NY 14853 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1263
DI 10.1158/1538-7445.AM2012-1263
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502365
ER
PT J
AU Gonzalez-Angulo, AM
Krop, I
Piha-Paul, S
Li, YS
Culotta, KS
Moulder-Thompson, S
Tsimberidou, A
Velez-Bravo, VM
Madden, TL
Norberg, LM
Doyle, A
Winder, EP
Mills, GB
Meric-Bernstam, F
Kurzrock, R
AF Gonzalez-Angulo, Ana M.
Krop, Ian
Piha-Paul, Sarina
Li, Yisheng
Culotta, Kirk S.
Moulder-Thompson, Stacy
Tsimberidou, Apostolia
Velez-Bravo, Vivianne M.
Madden, Timothy L.
Norberg, Lisa M.
Doyle, Austin
Winder, Eric P.
Mills, Gordon B.
Meric-Bernstam, Funda
Kurzrock, Razelle
TI Phase lb dose escalation and biomarker study of MK2206 in combination
with standard doses of weekly paclitaxel in patients with locally
advanced or metastatic solid tumors with expansion in advanced breast
cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gonzalez-Angulo, Ana M.; Piha-Paul, Sarina; Li, Yisheng; Culotta, Kirk S.; Moulder-Thompson, Stacy; Tsimberidou, Apostolia; Velez-Bravo, Vivianne M.; Madden, Timothy L.; Norberg, Lisa M.; Mills, Gordon B.; Meric-Bernstam, Funda; Kurzrock, Razelle] UT MD Anderson Canc Ctr, Houston, TX USA.
[Krop, Ian; Winder, Eric P.] Dana Farber Canc Inst, Boston, MA 02115 USA.
[Doyle, Austin] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-231
DI 10.1158/1538-7445.AM2012-LB-231
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601425
ER
PT J
AU Grade, M
Eimer, C
Emons, G
Kendziorra, E
Spitzner, M
Gaedcke, J
Wolff, H
Beissbarth, T
Ried, T
Pukrop, T
Ghadimi, M
AF Grade, Marian
Eimer, Christine
Emons, Georg
Kendziorra, Emil
Spitzner, Melanie
Gaedcke, Jochen
Wolff, Hendrik
Beissbarth, Tim
Ried, Thomas
Pukrop, Tobias
Ghadimi, Michael
TI The Wnt transcription factor TCF4 mediates resistance of colorectal
cancer cells to (chemo-) radiotherapy in a beta-catenin independent
manner
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Grade, Marian; Eimer, Christine; Emons, Georg; Kendziorra, Emil; Spitzner, Melanie; Gaedcke, Jochen; Wolff, Hendrik; Beissbarth, Tim; Pukrop, Tobias; Ghadimi, Michael] Univ Med Ctr, Gottingen, Germany.
[Ried, Thomas] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5729
DI 10.1158/1538-7445.AM2011-5729
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500032
ER
PT J
AU Gu, F
Pfeiffer, R
Taylor, P
Berndt, S
Yang, H
Han, S
Sigurdson, A
Toro, J
Mirabello, L
Freedman, N
Abnet, C
Dawsey, S
Hu, N
Qiao, YL
Ding, T
Brenner, A
Garcia-Closas, M
Brinton, L
Lissowska, J
Wentzensen, N
Kratz, C
Moore, L
Ziegler, R
Chow, WH
Savage, S
Burdette, L
Yeager, M
Chanock, S
Tucker, M
Goldstein, A
Yang, R
AF Gu, Fangyi
Pfeiffer, Ruth
Taylor, Phil
Berndt, Sonja
Yang, Hanna
Han, Summer
Sigurdson, Alice
Toro, Jorge
Mirabello, Lisa
Freedman, Neal
Abnet, Christian
Dawsey, Sanford
Hu, Nan
Qiao, You-Lin
Ding, Ti
Brenner, Alina
Garcia-Closas, Montserrat
Brinton, Louise
Lissowska, Jolanta
Wentzensen, Nicolas
Kratz, Christian
Moore, Lee
Ziegler, Regina
Chow, Wong-Ho
Savage, Sharon
Burdette, Laurie
Yeager, Meredith
Chanock, Stephen
Tucker, Margaret
Goldstein, Alisa
Yang, Rose
TI Genetic variants in the 9p21 region in relation to the risk of multiple
tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gu, Fangyi; Pfeiffer, Ruth; Taylor, Phil; Berndt, Sonja; Yang, Hanna; Han, Summer; Sigurdson, Alice; Toro, Jorge; Mirabello, Lisa; Freedman, Neal; Abnet, Christian; Dawsey, Sanford; Hu, Nan; Brenner, Alina; Brinton, Louise; Wentzensen, Nicolas; Kratz, Christian; Moore, Lee; Ziegler, Regina; Chow, Wong-Ho; Savage, Sharon; Burdette, Laurie; Yeager, Meredith; Chanock, Stephen; Tucker, Margaret; Goldstein, Alisa; Yang, Rose] NCI, Rockville, MD USA.
[Qiao, You-Lin] CICAMS, Beijing, Peoples R China.
[Ding, Ti] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China.
[Garcia-Closas, Montserrat] Inst Canc Res, Belmont, England.
[Lissowska, Jolanta] M Sklodowska Curie Canc Ctr, Warsaw, Poland.
RI Qiao, You-Lin/B-4139-2012
OI Qiao, You-Lin/0000-0001-6380-0871
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-330
DI 10.1158/1538-7445.AM2012-LB-330
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603157
ER
PT J
AU Guedez, L
Stetler-Stevenson, WG
AF Guedez, Liliana
Stetler-Stevenson, William G.
TI TIMP-2 inhibits angiogenesis induced by tumor associated myeloid
suppressor cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Guedez, Liliana; Stetler-Stevenson, William G.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1376
DI 10.1158/1538-7445.AM2012-1376
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504425
ER
PT J
AU Gulley, JL
Madan, RA
Schlom, J
AF Gulley, James L.
Madan, Ravi A.
Schlom, Jeffrey
TI Current status of recombinant pox-viral vaccines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Gulley, James L.; Madan, Ravi A.; Schlom, Jeffrey] NCI, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016
OI Gulley, James/0000-0002-6569-2912
NR 12
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA PL03-02
DI 10.1158/1538-7445.AM2012-PL03-02
PG 3
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500211
ER
PT J
AU Guo, R
Morin, P
AF Guo, Rong
Morin, Patrice
TI Identification of signaling pathways involved in the regulation of let-7
in ovarian cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Guo, Rong; Morin, Patrice] NIA, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2310
DI 10.1158/1538-7445.AM2012-2310
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502324
ER
PT J
AU Guo, ZJ
Mitra, R
Luo, XH
Capdevila, J
Lipscomb, J
David, PA
AF Guo, Zhijun
Mitra, Ranjana
Luo, Xiangghua
Capdevila, Jorge
Lipscomb, Johnl
David, Potter A.
TI CYP3A4 epoxygenase mediates hypoxia-induced biosynthesis of
epoxyeicosatrienoic acids (+/-)-11,12-and (+/-)-14,15-EET in breast
cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Guo, Zhijun; Luo, Xiangghua; Lipscomb, Johnl; David, Potter A.] Univ Minnesota, Minneapolis, MN USA.
[Mitra, Ranjana] NCI, Las Vegas, NV USA.
[Capdevila, Jorge] Vanderbilt Univ, Nashville, TN 37235 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 942
DI 10.1158/1538-7445.AM2012-942
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601493
ER
PT J
AU Hancock, CN
Phang, J
AF Hancock, Chad N.
Phang, James
TI The oxidation of proline by proline oxidase provides a regulated source
of ROS for mitochondria derived cellular signaling
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hancock, Chad N.; Phang, James] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1119
DI 10.1158/1538-7445.AM2012-1119
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606026
ER
PT J
AU Harris, M
Shin, DM
Choi, S
Low, B
Miller, E
Rybinski, B
Bronson, R
Yun, K
AF Harris, Molly
Shin, Dong-mi
Choi, Seungbum
Low, Benjamin
Miller, Emily
Rybinski, Brad
Bronson, Roderick
Yun, Kyuson
TI Cancer stem cell heterogeneity and cell-of-origin in medulloblastomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Harris, Molly] Univ Maine, Orono, ME USA.
[Shin, Dong-mi] NIAID, NIH, Bethesda, MD 20892 USA.
[Choi, Seungbum; Low, Benjamin; Miller, Emily; Rybinski, Brad; Yun, Kyuson] Jackson Lab, Ctr Canc, Bar Harbor, ME 04609 USA.
[Bronson, Roderick] Dana Farber Canc Inst, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3300
DI 10.1158/1538-7445.AM2012-3300
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504443
ER
PT J
AU Haso, W
Lee, D
Morgan, R
Pastan, I
Mackall, C
Orentas, RJ
AF Haso, Waleed
Lee, Daniel
Morgan, Richard
Pastan, Ira
Mackall, Crystal
Orentas, Rimas J.
TI Generation and optimization of a chimeric antigen receptor against human
CD22: A new immunotherapeutic agent for adoptive immunotherapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Haso, Waleed; Lee, Daniel; Morgan, Richard; Pastan, Ira; Mackall, Crystal; Orentas, Rimas J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3504
DI 10.1158/1538-7445.AM2012-3504
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500377
ER
PT J
AU Hayman, TJ
Bae, H
Camphausen, K
Tofilon, PJ
AF Hayman, Thomas J.
Bae, Heekyong
Camphausen, Kevin
Tofilon, Philip J.
TI Competitive inhibition of mTOR results in tumor specific
radiosensitization
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hayman, Thomas J.; Bae, Heekyong; Camphausen, Kevin; Tofilon, Philip J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5727
DI 10.1158/1538-7445.AM2011-5727
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500030
ER
PT J
AU Heckel, D
Padget, M
Cherukuri, S
Morisot, S
Guo, Y
Wayne, AS
Brown, PA
Civin, CI
AF Heckel, Diana
Padget, Michelle
Cherukuri, Srujana
Morisot, Sebastien
Guo, Yin
Wayne, Alan S.
Brown, Patrick A.
Civin, Curt I.
TI Expression of CD22, a late B lymphoid antigen, does not distinguish
leukemia stem cells from the bulk population in acute lymphoblastic
leukemia cases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Heckel, Diana; Padget, Michelle; Cherukuri, Srujana; Morisot, Sebastien; Guo, Yin; Civin, Curt I.] Univ Maryland, Sch Med, Dept Pediat, Ctr Stem Cell Biol & Regenerat Med, Baltimore, MD 21201 USA.
[Wayne, Alan S.] NCI, Bethesda, MD 20892 USA.
[Brown, Patrick A.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3385
DI 10.1158/1538-7445.AM2012-3385
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505355
ER
PT J
AU Hesse, JE
Innes, C
Liu, LW
Paules, RS
AF Hesse, Jill E.
Innes, Cynthia
Liu, Liwen
Paules, Richard S.
TI Genome-wide small RNA sequencing and gene expression analysis reveals a
microRNA profile reflective of cancer-susceptibility in ATM deficient
human mammary epithelial cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hesse, Jill E.; Innes, Cynthia; Liu, Liwen; Paules, Richard S.] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-461
DI 10.1158/1538-7445.AM2012-LB-461
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501295
ER
PT J
AU Hirt, C
Meier, M
Yu, K
Schuler, F
Janz, S
Dolken, G
Rabkin, CS
AF Hirt, Carsten
Meier, Manuela
Yu, Kelly
Schueler, Frank
Janz, Siegfried
Doelken, Gottfried
Rabkin, Charles S.
TI Population prevalence of consensus translocations in follicular and
mantle cell lymphomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hirt, Carsten; Meier, Manuela; Schueler, Frank; Doelken, Gottfried] Ernst Moritz Arndt Univ Greifswald, Greifswald, Germany.
[Yu, Kelly; Rabkin, Charles S.] NIH, Rockville, MD USA.
[Janz, Siegfried] Univ Iowa, Carver Coll Med, Iowa City, IA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1672
DI 10.1158/1538-7445.AM2012-1672
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602285
ER
PT J
AU Hofmann, JN
Hosgood, HD
Liu, CS
Chow, WH
Moore, LE
Lan, Q
Rothman, N
Purdue, MP
AF Hofmann, Jonathan N.
Hosgood, H. Dean
Liu, Chin-San
Chow, Wong-Ho
Moore, Lee E.
Lan, Qing
Rothman, Nathaniel
Purdue, Mark P.
TI A prospective study of blood mitochondrial DNA copy number and risk of
renal cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hofmann, Jonathan N.; Hosgood, H. Dean; Chow, Wong-Ho; Moore, Lee E.; Lan, Qing; Rothman, Nathaniel; Purdue, Mark P.] NCI, DCEG, Bethesda, MD 20892 USA.
[Liu, Chin-San] Changhua Christian Hosp, Changhua, Taiwan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4461
DI 10.1158/1538-7445.AM2012-4461
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603268
ER
PT J
AU Hong, B
Dicker, DT
Kopelovich, L
El-Deiry, WS
AF Hong, Bo
Dicker, David T.
Kopelovich, Levy
El-Deiry, Wafik S.
TI Prodigiosin and its structural analogue rescue deficient p53 pathway
signaling and anti-tumor effects via p73 upregulation in p53 mutant and
null colorectal cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hong, Bo; Dicker, David T.; El-Deiry, Wafik S.] Penn State Hershey Med Ctr, Penn State Hershey Canc Inst, Hershey, PA USA.
[Kopelovich, Levy] NCI, Div Canc Prevent, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1172
DI 10.1158/1538-7445.AM2012-1172
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503136
ER
PT J
AU Horne, HN
Sherman, ME
Yang, XHR
Garcia-Closas, M
Lissowska, J
Brinton, LA
Chanock, SJ
Figueroa, JD
AF Horne, Hisani N.
Sherman, Mark E.
Yang, Xiaohong R.
Garcia-Closas, Montserrat
Lissowska, Jolanta
Brinton, Louise A.
Chanock, Stephen J.
Figueroa, Jonine D.
TI Association of variant rs2046210 at 6q25.1 (ESR1) with breast cancer
risk suggests heterogeneity by E-cadherin tumor tissue expression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Horne, Hisani N.; Sherman, Mark E.; Yang, Xiaohong R.; Brinton, Louise A.; Chanock, Stephen J.; Figueroa, Jonine D.] NCI, Bethesda, MD 20892 USA.
[Garcia-Closas, Montserrat] Inst Canc Res, Sutton, Surrey, England.
[Lissowska, Jolanta] Maria Sklodowska Curie Mem Canc Ctr, Warsaw, Poland.
[Lissowska, Jolanta] Inst Oncol, Warsaw, Poland.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-336
DI 10.1158/1538-7445.AM2012-LB-336
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603224
ER
PT J
AU Hosgood, HD
Pao, W
Rothman, N
Wei, H
Kim, C
Pan, H
Kuchinsky, K
Jones, K
Xu, J
Vermeulen, R
Simko, J
Lan, Q
AF Hosgood, Howard D.
Pao, William
Rothman, Nathaniel
Wei, Hu
Kim, Christopher
Pan, Helen
Kuchinsky, Kyle
Jones, Kirk
Xu, Jun
Vermeulen, Roel
Simko, Jeffery
Lan, Qing
TI Somatic driver mutations among never smoking female lung cancer cases in
China identify unique mutation pattern that may be associated with
household coal burning
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hosgood, Howard D.; Rothman, Nathaniel; Wei, Hu; Kim, Christopher; Lan, Qing] NCI, Bethesda, MD 20892 USA.
[Pao, William; Pan, Helen] Vanderbilt Ingram Canc Ctr, Nashville, TN USA.
[Kuchinsky, Kyle; Jones, Kirk; Simko, Jeffery] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Xu, Jun] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
[Vermeulen, Roel] Utrect Univ, Utrecht, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5479
DI 10.1158/1538-7445.AM2012-5479
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602141
ER
PT J
AU Hu, W
Xu, J
Bassig, BA
Zheng, TZ
Zhang, YW
Berndt, SI
Holford, TR
Hosgood, HD
Leaderer, B
Menashe, I
Boyle, P
Chanock, S
Lan, Q
Rothman, N
AF Hu, Wei
Xu, Jun
Bassig, Bryan A.
Zheng, Tongzhang
Zhang, Yawei
Berndt, Sonja I.
Holford, Theodore R.
Hosgood, H. Dean
Leaderer, Brian
Menashe, Idan
Boyle, Peter
Chanock, Stephen
Lan, Qing
Rothman, Nathaniel
TI Polymorphisms in pattern recognition genes in the innate immunity system
and risk of non-Hodgkin lymphoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hu, Wei; Bassig, Bryan A.; Berndt, Sonja I.; Hosgood, H. Dean; Menashe, Idan; Chanock, Stephen; Lan, Qing; Rothman, Nathaniel] NCI, Rockville, MD USA.
[Xu, Jun] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
[Zheng, Tongzhang; Zhang, Yawei; Holford, Theodore R.; Leaderer, Brian] Yale Univ, New Haven, CT USA.
[Boyle, Peter] Int Prevent Res Inst, Lyon, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2641
DI 10.1158/1538-7445.AM2012-2641
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602270
ER
PT J
AU Hu, Y
Wu, G
Rusch, M
Lukes, L
Buetow, KH
Zhang, JH
Hunter, KW
AF Hu, Ying
Wu, Gang
Rusch, Michael
Lukes, Luanne
Buetow, Kenneth H.
Zhang, Jinghui
Hunter, Kent W.
TI An integrated cross-species transcriptional network analysis of
metastatic susceptibility
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hu, Ying; Lukes, Luanne; Buetow, Kenneth H.; Hunter, Kent W.] NCI, Bethesda, MD 20892 USA.
[Wu, Gang; Rusch, Michael; Zhang, Jinghui] St Jude Childrens Res Hosp, Memphis, TN USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2980
DI 10.1158/1538-7445.AM2012-2980
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505105
ER
PT J
AU Huang, B
Gao, YT
Shu, XO
Wen, WQ
Yang, G
Li, GL
Ji, BT
Li, HL
Chow, WH
Zheng, W
Cai, QY
AF Huang, Bo
Gao, Yu-Tang
Shu, Xiao Ou
Wen, Wanqing
Yang, Gong
Li, Guoliang
Ji, Bu-Tian
Li, Hong-Lan
Chow, Wong Ho
Zheng, Wei
Cai, Qiuyin
TI Mitochondrial DNA copy number and colorectal cancer risk: Results from
the Shanghai Women's Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Huang, Bo; Shu, Xiao Ou; Wen, Wanqing; Yang, Gong; Li, Guoliang; Zheng, Wei; Cai, Qiuyin] Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37212 USA.
[Huang, Bo; Shu, Xiao Ou; Wen, Wanqing; Yang, Gong; Li, Guoliang; Zheng, Wei; Cai, Qiuyin] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Dept Med, Nashville, TN 37212 USA.
[Huang, Bo; Shu, Xiao Ou; Wen, Wanqing; Yang, Gong; Li, Guoliang; Zheng, Wei; Cai, Qiuyin] Vanderbilt Ingram Canc Ctr, Nashville, TN USA.
[Gao, Yu-Tang; Li, Hong-Lan] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China.
[Ji, Bu-Tian; Chow, Wong Ho] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1126
DI 10.1158/1538-7445.AM2012-1126
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606033
ER
PT J
AU Huppi, K
Ou, OL
Pitt, JJ
Wahlberg, B
Jones, TL
Rodriguez-Canales, J
Erickson, HS
Emmert-Buck, M
Caplen, NJ
AF Huppi, Konrad
Ou, Oliver L.
Pitt, Jason J.
Wahlberg, Brady
Jones, Tamara L.
Rodriguez-Canales, Jaime
Erickson, Heidi S.
Emmert-Buck, Michael
Caplen, Natasha J.
TI Noncoding RNAs of the 8q24 locus
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Huppi, Konrad; Ou, Oliver L.; Pitt, Jason J.; Wahlberg, Brady; Jones, Tamara L.; Rodriguez-Canales, Jaime; Emmert-Buck, Michael; Caplen, Natasha J.] NCI, Bethesda, MD 20892 USA.
[Erickson, Heidi S.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 199
DI 10.1158/1538-7445.AM2012-199
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606138
ER
PT J
AU Hutt, M
Lim, KJ
Warren, K
Chang, HT
Eberhart, CG
Raabe, EH
AF Hutt, Marianne
Lim, Kah Jing
Warren, Katherine
Chang, Howard T.
Eberhart, Charles G.
Raabe, Eric H.
TI High-level activation of the Notch pathway in diffuse intrinsic pontine
glioma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Hutt, Marianne; Lim, Kah Jing; Eberhart, Charles G.] Johns Hopkins Univ, Div Neuropathol, Baltimore, MD USA.
[Warren, Katherine] NIH, Pediat Oncol Branch, Bethesda, MD 20892 USA.
[Chang, Howard T.] Michigan State Univ, Dept Neurol & Ophthalmol, E Lansing, MI 48824 USA.
[Raabe, Eric H.] Johns Hopkins Univ, Div Pediat Oncol, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2480
DI 10.1158/1538-7445.AM2012-2480
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501474
ER
PT J
AU Iyer, S
Xiong, W
Tang, DL
Jedrychowski, W
Chanock, S
Wang, S
Stigter, L
Mroz, E
Perera, F
AF Iyer, Shoba
Xiong, Wei
Tang, Deliang
Jedrychowski, Wieslaw
Chanock, Stephen
Wang, Shuang
Stigter, Laura
Mroz, Elzbieta
Perera, Frederica
TI Interactions between polycyclic aromatic hydrocarbon exposure and
genetic polymorphisms on benzo(a)pyrene-DNA adducts in a Polish cohort
of mothers and newborns
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Iyer, Shoba; Xiong, Wei; Tang, Deliang; Wang, Shuang; Stigter, Laura; Perera, Frederica] Columbia Univ, New York, NY USA.
[Jedrychowski, Wieslaw; Mroz, Elzbieta] Jagiellonian Univ, Coll Med, Krakow, Poland.
[Chanock, Stephen] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2643
DI 10.1158/1538-7445.AM2012-2643
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602272
ER
PT J
AU Jacobs, KB
Yeager, M
Zhou, WY
Hoover, RN
Real, FX
Fraumeni, JF
Caporaso, NE
Tucker, M
Rothman, N
Perez-Jurado, LA
Chanock, SJ
AF Jacobs, Kevin B.
Yeager, Meredith
Zhou, Weiyin
Hoover, Robert N.
Real, Francisco X.
Fraumeni, Joseph F.
Caporaso, Neil E.
Tucker, Margaret
Rothman, Nathaniel
Perez-Jurado, Luis A.
Chanock, Stephen J.
CA DCEG Mosaicism Study Grp
TI The aging genome: Genetic mosaicism and its relationship to cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jacobs, Kevin B.; Yeager, Meredith; Zhou, Weiyin] NCI, SAIC Frederick Inc, Frederick, MD 21701 USA.
[Hoover, Robert N.; Fraumeni, Joseph F.; Caporaso, Neil E.; Tucker, Margaret; Rothman, Nathaniel; Chanock, Stephen J.] NCI, Rockville, MD USA.
[Real, Francisco X.; Perez-Jurado, Luis A.] Univ Pompeu Fabra, Barcelona, Spain.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3110
DI 10.1158/1538-7445.AM2012-3110
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605197
ER
PT J
AU Jain, M
Zhang, LS
Joshi, B
Puri, R
He, M
Kebebew, E
AF Jain, Meenu
Zhang, Lisa
Joshi, Bharat
Puri, Raj
He, Mei
Kebebew, Electron
TI IL13R alpha 2 regulates cell invasion, and is a therapeutic target for
adrenocortical carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jain, Meenu; Zhang, Lisa; He, Mei; Kebebew, Electron] NCI, Bethesda, MD 20892 USA.
[Joshi, Bharat; Puri, Raj] US FDA, Bethesda, MD 20014 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3932
DI 10.1158/1538-7445.AM2012-3932
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602167
ER
PT J
AU Janakiram, NB
Mohammed, A
Zhang, YT
Brewer, M
Lightfoot, S
Steele, VE
Rao, CV
AF Janakiram, Naveena B.
Mohammed, Altaf
Zhang, Yuting
Brewer, Misty
Lightfoot, Stan
Steele, Vernon E.
Rao, Chinthalapally V.
TI Chemopreventive efficacy of raloxifene, bexarotene and their combination
on the progression of AOM-induced colon adenomas to adenocarcinomas in
F344 rats
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Janakiram, Naveena B.; Mohammed, Altaf; Zhang, Yuting; Brewer, Misty; Lightfoot, Stan; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
[Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1633
DI 10.1158/1538-7445.AM2012-1633
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503370
ER
PT J
AU Jansen, SA
Song, YR
O'Sullivan, N
Ileva, L
Lu, L
Van Dyke, T
AF Jansen, Sanaz A.
Song, Yurong
O'Sullivan, Norene
Ileva, Lilia
Lu, Lucy
Van Dyke, Terry
TI Modeling glioblastoma in the mouse: Insights from noninvasive imaging
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jansen, Sanaz A.; Song, Yurong; O'Sullivan, Norene; Ileva, Lilia; Lu, Lucy; Van Dyke, Terry] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2441
DI 10.1158/1538-7445.AM2012-2441
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505371
ER
PT J
AU Jarrett, SG
Novak, M
Merlino, G
Slominski, A
Kaetzel, DM
AF Jarrett, Stuart G.
Novak, Marian
Merlino, Glenn
Slominski, Andrzej
Kaetzel, David M.
TI Genome-stabilizing functions of NM23 in metastatic melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jarrett, Stuart G.; Novak, Marian; Kaetzel, David M.] Univ Kentucky, Coll Med, Lexington, KY USA.
[Jarrett, Stuart G.; Novak, Marian; Kaetzel, David M.] Markey Canc Ctr, Lexington, KY USA.
[Merlino, Glenn] NCI, Bethesda, MD 20892 USA.
[Slominski, Andrzej] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3428
DI 10.1158/1538-7445.AM2012-3428
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504057
ER
PT J
AU Jenkins, C
Stone, S
Sobeck, A
Wang, WD
Hoatlin, ME
AF Jenkins, Chelsea
Stone, Stacie
Sobeck, Alex
Wang, Weidong
Hoatlin, Maureen E.
TI A new protein complex containing the Fanconi protein FANCM and Rif1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jenkins, Chelsea; Hoatlin, Maureen E.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Stone, Stacie] Novartis, Portland, OR USA.
[Sobeck, Alex] Univ Minnesota, Minneapolis, MN USA.
[Wang, Weidong] NIA, NIH, Baltimore, MD 21224 USA.
OI Jenkins, Chelsea/0000-0002-9403-0619
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2128
DI 10.1158/1538-7445.AM2012-2128
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605171
ER
PT J
AU Jiang, Q
Xiao, ZX
Willette-Brown, J
Back, T
Wiltrout, RH
Hu, YL
AF Jiang, Qun
Xiao, Zuoxiang
Willette-Brown, Jami
Back, Timothy
Wiltrout, Robert H.
Hu, Yinling
TI IKK alpha links inflammation and tumorigenesis in a mouse model of lung
squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jiang, Qun; Xiao, Zuoxiang; Willette-Brown, Jami; Back, Timothy; Wiltrout, Robert H.; Hu, Yinling] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2561
DI 10.1158/1538-7445.AM2012-2561
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600253
ER
PT J
AU Jochems, C
Tucker, JA
Poole, DJ
Beatson, M
Mulguin, M
Madan, RA
Figg, WD
Dahut, WL
Gulley, JL
Schlom, J
Tsang, KY
AF Jochems, Caroline
Tucker, Jo A.
Poole, Diane J.
Beatson, Melony
Mulguin, Marcia
Madan, Ravi A.
Figg, William D.
Dahut, William L.
Gulley, James L.
Schlom, Jeffrey
Tsang, Kwong-Yok
TI Combination treatment with Bevacizumab, Lenalidomide, Docetaxel and
Prednisone (ART -P) does not impact the immune response in patients with
metastatic castration -resistant prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jochems, Caroline; Tucker, Jo A.; Poole, Diane J.; Beatson, Melony; Mulguin, Marcia; Madan, Ravi A.; Figg, William D.; Dahut, William L.; Gulley, James L.; Schlom, Jeffrey; Tsang, Kwong-Yok] NCI, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016; Figg Sr, William/M-2411-2016
OI Gulley, James/0000-0002-6569-2912;
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5379
DI 10.1158/1538-7445.AM2012-5379
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500300
ER
PT J
AU Johannessen, L
Remsberg, JR
Ivanova, A
Gaponenko, V
Khavrutskii, L
Tarasov, SG
Dean, M
Kates, J
Tarasova, NI
AF Johannessen, Liv
Remsberg, Jarrett R.
Ivanova, Alla
Gaponenko, Vadim
Khavrutskii, Lyuba
Tarasov, Sergey G.
Dean, Michael
Kates, Joseph
Tarasova, Nadya I.
TI Potent inhibitors of RAS pathways that bind directly to Ras proteins
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Johannessen, Liv; Remsberg, Jarrett R.; Khavrutskii, Lyuba; Tarasov, Sergey G.; Dean, Michael; Tarasova, Nadya I.] NCI, Frederick, MD 21701 USA.
[Ivanova, Alla] Vanderbilt Univ, Nashville, TN 37235 USA.
[Gaponenko, Vadim] Univ Illinois, Chicago, IL USA.
[Kates, Joseph] Calidris Therapeut, Kirkland, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-426
DI 10.1158/1538-7445.AM2012-LB-426
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600237
ER
PT J
AU Johansson, HE
Orjalo, AV
Dadhich, S
Park, MH
AF Johansson, Hans E.
Orjalo, Arturo V.
Dadhich, Swati
Park, Myung Hee
TI Hypusine pathway gene expression examined by single molecule RNA
fluorescence in situ hybridization (smRNA-FISH)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Johansson, Hans E.; Orjalo, Arturo V.] Biosearch Technol Inc, Novato, CA USA.
[Dadhich, Swati; Park, Myung Hee] NIDCR, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4209
DI 10.1158/1538-7445.AM2012-4209
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502447
ER
PT J
AU Jube, S
Rivera, Z
Bianchi, M
Powers, A
Wang, E
Pagano, I
Pass, HI
Gaudino, G
Carbone, M
Yang, HN
AF Jube, Sandro
Rivera, Zeyana
Bianchi, Marco
Powers, Amy
Wang, Ena
Pagano, Ian
Pass, Harvey I.
Gaudino, Giovanni
Carbone, Michele
Yang, Haining
TI High mobility group box 1 secretion supports tumor progression of human
malignant mesothelioma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Jube, Sandro; Rivera, Zeyana; Powers, Amy; Pagano, Ian; Gaudino, Giovanni; Carbone, Michele; Yang, Haining] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
[Bianchi, Marco] San Raffaele Univ & Res Inst, Milan, Italy.
[Wang, Ena] NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
[Pass, Harvey I.] NYU, Sch Med, Dept Cardiothorac Surg, New York, NY USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1557
DI 10.1158/1538-7445.AM2012-1557
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500339
ER
PT J
AU Juhasz, A
Antony, S
Wu, YZ
Lu, JM
Jiang, GJ
Liu, H
Roy, K
Doroshow, JH
AF Juhasz, Agnes
Antony, Smitha
Wu, Yongzhong
Lu, Jiamo
Jiang, Guojian
Liu, Han
Roy, Krishnendu
Doroshow, James H.
TI Effect of stable knockdown of NOX1 gene expression with siRNA in human
colon cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Juhasz, Agnes; Antony, Smitha; Wu, Yongzhong; Lu, Jiamo; Jiang, Guojian; Liu, Han; Roy, Krishnendu; Doroshow, James H.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3066
DI 10.1158/1538-7445.AM2012-3066
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605092
ER
PT J
AU Kang, ZG
Cao, L
AF Kang, Zhigang
Cao, Liang
TI Genome-wide shRNA screening identifies candidate proteins modulating the
extrinsic apoptotic pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kang, Zhigang; Cao, Liang] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 254
DI 10.1158/1538-7445.AM2012-254
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501422
ER
PT J
AU Kaur, G
Kondapaka, SB
Teicher, BA
AF Kaur, Gurmeet
Kondapaka, Sudhir B.
Teicher, Beverly A.
TI Comparison of endpoints and data analysis methods for exposure of human
tumor cells to dasatinib (NSC732517) and 6-MP (NSC755) in culture
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kaur, Gurmeet; Kondapaka, Sudhir B.] NCI, Frederick, MD 21701 USA.
[Teicher, Beverly A.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3713
DI 10.1158/1538-7445.AM2012-3713
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603197
ER
PT J
AU Kedei, N
Telek, A
Michalowski, AM
Kraft, MB
Li, W
Poudel, YB
Rudra, A
Petersen, ME
Keck, GE
Blumberg, PM
AF Kedei, Noemi
Telek, Andrea
Michalowski, Aleksandra M.
Kraft, Matthew B.
Li, Wei
Poudel, Yam B.
Rudra, Arnab
Petersen, Mark E.
Keck, Gary E.
Blumberg, Peter M.
TI Comparison of transcriptional response to phorbol ester, bryostatin 1,
and bryostatin analogues in LNCaP and U937 cancer cell lines provides
insight into their differential mechanism of action
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kedei, Noemi; Telek, Andrea; Michalowski, Aleksandra M.; Blumberg, Peter M.] NCI, Bethesda, MD 20892 USA.
[Kraft, Matthew B.; Li, Wei; Poudel, Yam B.; Rudra, Arnab; Petersen, Mark E.; Keck, Gary E.] Univ Utah, Salt Lake City, UT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3815
DI 10.1158/1538-7445.AM2012-3815
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500093
ER
PT J
AU Kessler, JD
Kahle, KT
Sun, TT
Meerbrey, KL
Schlabach, MR
Schmitt, EM
Skinner, SO
Xu, QK
Li, MZ
Hartman, ZC
Rao, M
Yu, P
Dominguez-Vidana, R
Liang, AC
Solimin, NL
Bernardi, RJ
Yu, B
Hsu, T
Golding, I
Luo, J
Osborne, CK
Creighton, C
Hilsenbeck, SG
Schiff, R
Shaw, CA
Elledge, SJ
Westbrook, TF
AF Kessler, Jessica D.
Kahle, Kristopher T.
Sun, Tingting
Meerbrey, Kristen L.
Schlabach, Michael R.
Schmitt, Earlene M.
Skinner, Samuel O.
Xu, Qikai
Li, Mamie Z.
Hartman, Zachary C.
Rao, Mitchell
Yu, Peng
Dominguez-Vidana, Rocio
Liang, Anthony C.
Solimin, Nicole L.
Bernardi, Ronald J.
Yu, Bing
Hsu, Tiffany
Golding, Ido
Luo, Ji
Osborne, C. Kent
Creighton, Chad
Hilsenbeck, Susan G.
Schiff, Rachel
Shaw, Chad A.
Elledge, Stephen J.
Westbrook, Thomas F.
TI A sumoylation-dependent transcriptional subprogram is required for
Myc-driven tumorigenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kessler, Jessica D.; Sun, Tingting; Meerbrey, Kristen L.; Schmitt, Earlene M.; Skinner, Samuel O.; Rao, Mitchell; Yu, Peng; Dominguez-Vidana, Rocio; Bernardi, Ronald J.; Hsu, Tiffany; Golding, Ido; Osborne, C. Kent; Creighton, Chad; Hilsenbeck, Susan G.; Schiff, Rachel; Shaw, Chad A.; Westbrook, Thomas F.] Baylor Coll Med, Houston, TX 77030 USA.
[Kahle, Kristopher T.; Schlabach, Michael R.; Xu, Qikai; Li, Mamie Z.; Liang, Anthony C.; Solimin, Nicole L.; Elledge, Stephen J.] Harvard Univ, Sch Med, Boston, MA USA.
[Hartman, Zachary C.] Duke Univ, Durham, NC USA.
[Yu, Bing; Luo, Ji] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3091
DI 10.1158/1538-7445.AM2012-3091
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605118
ER
PT J
AU Khotskaya, YB
Shen, J
Chang, SS
Yu, DH
Steeg, PS
Hung, MC
AF Khotskaya, Yekaterina B.
Shen, Jia
Chang, Shih-Shin
Yu, Dihua
Steeg, Patricia S.
Hung, Mien-Chie
TI A novel model of breast cancer metastasis: Killing two birds with one
stone
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Khotskaya, Yekaterina B.; Shen, Jia; Chang, Shih-Shin; Yu, Dihua; Hung, Mien-Chie] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Steeg, Patricia S.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3290
DI 10.1158/1538-7445.AM2012-3290
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504319
ER
PT J
AU Kiesel, BF
Parise, RA
Tjornelund, J
Christensen, MK
Loza, E
Chu, E
Kummar, S
Beumer, JH
AF Kiesel, Brian F.
Parise, Robert A.
Tjornelund, Jette
Christensen, Mette K.
Loza, Einars
Chu, Edward
Kummar, Shivaani
Beumer, Jan H.
TI Quantitation of the HDAC inhibitor belinostat (PXD-101) and metabolites
in human plasma by a novel LC-MS/MS assay.
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kiesel, Brian F.; Parise, Robert A.; Chu, Edward; Beumer, Jan H.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
[Tjornelund, Jette] TopoTarget, Copenhagen, Denmark.
[Christensen, Mette K.] Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark.
[Loza, Einars] Latvian Inst Organ Synth, Riga, Latvia.
[Kummar, Shivaani] NCI, NIH, Bethesda, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 759
DI 10.1158/1538-7445.AM2012-759
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601311
ER
PT J
AU Kim, C
Chapman, R
Hu, W
He, XZ
Hosgood, HD
Liu, LZ
Lai, H
Tian, LW
Chen, W
Rothman, N
Lan, Q
AF Kim, Christopher
Chapman, Robert
Hu, Wei
He, Xingzhou
Hosgood, H. Dean
Liu, Larry Z.
Lai, Hong
Tian, Linwei
Chen, Wei
Rothman, Nathaniel
Lan, Qing
TI Indoor coal smoke exposure, tobacco use, and lung cancer risk in
Xuanwei, China
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kim, Christopher; Hu, Wei; Hosgood, H. Dean; Rothman, Nathaniel; Lan, Qing] NIH, Rockville, MD USA.
[Chapman, Robert] US EPA, Res Triangle Pk, NC 27711 USA.
[He, Xingzhou] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
[Liu, Larry Z.] Pfizer, New York, NY USA.
[Lai, Hong] Johns Hopkins Univ, Baltimore, MD USA.
[Tian, Linwei] Chinese Univ Hong Kong, Ma Liu Shui, Hong Kong, Peoples R China.
[Chen, Wei] Forest Labs Inc, New York, NY USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5478
DI 10.1158/1538-7445.AM2012-5478
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602140
ER
PT J
AU Kim, CJ
Cozen, W
Weiss, LM
Bhatia, K
Cockburn, M
Hawes, D
Wang, SS
Engels, EA
Morton, LM
AF Kim, Clara J.
Cozen, Wendy
Weiss, Lawrence M.
Bhatia, Kishor
Cockburn, Myles
Hawes, Debra
Wang, Sophia S.
Engels, Eric A.
Morton, Lindsay M.
TI Molecular characteristics of diffuse large B-cell lymphoma in
HIV-positive and HIV-negative patients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kim, Clara J.; Bhatia, Kishor; Engels, Eric A.; Morton, Lindsay M.] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Rockville, MD USA.
[Cozen, Wendy; Cockburn, Myles; Hawes, Debra] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Cozen, Wendy; Cockburn, Myles; Hawes, Debra] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
[Weiss, Lawrence M.] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA.
[Wang, Sophia S.] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA.
[Wang, Sophia S.] City Hope Natl Med Ctr, Duarte, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4490
DI 10.1158/1538-7445.AM2012-4490
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602020
ER
PT J
AU Kim, MKH
Annunziata, C
AF Kim, Marianne K. H.
Annunziata, Christina
TI Dual shRNA technique to screen gene-to-gene interaction
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kim, Marianne K. H.; Annunziata, Christina] NCI, NIH, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-421
DI 10.1158/1538-7445.AM2012-LB-421
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501282
ER
PT J
AU Kinyamu, HK
Yang, J
Archer, TK
AF Kinyamu, Harriet K.
Yang, Jun
Archer, Trevor K.
TI LIN28 mRNA targets in breast cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kinyamu, Harriet K.; Yang, Jun; Archer, Trevor K.] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4192
DI 10.1158/1538-7445.AM2012-4192
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502429
ER
PT J
AU Kobayashi, H
Mitsunaga, M
Nakajima, T
Sano, K
Choyke, PL
AF Kobayashi, Hisataka
Mitsunaga, Makoto
Nakajima, Takahito
Sano, Kohei
Choyke, Peter L.
TI Target-molecular specific near infrared cancer photoimmunotherapy:
Detection, treatment, and monitoring of tumors with a theranostic
fluorescent probe
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kobayashi, Hisataka; Mitsunaga, Makoto; Nakajima, Takahito; Sano, Kohei; Choyke, Peter L.] NCI, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4830
DI 10.1158/1538-7445.AM2012-4830
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602313
ER
PT J
AU Kohaar, I
Mumy, A
Tang, W
Porter-Gill, P
Fu, YP
Prokunina-Olsson, L
AF Kohaar, Indu
Mumy, Adam
Tang, Wei
Porter-Gill, Patricia
Fu, Yi-Ping
Prokunina-Olsson, Ludmila
TI Allele-specific effect of rs2294008 on mRNA and protein expression of
the prostate stem cell antigen (PSCA) in human normal and tumor bladder
tissue
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kohaar, Indu; Mumy, Adam; Tang, Wei; Porter-Gill, Patricia; Fu, Yi-Ping; Prokunina-Olsson, Ludmila] NCI, DCEG, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5126
DI 10.1158/1538-7445.AM2012-5126
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606207
ER
PT J
AU Kosturko, GW
Bulut, G
Hong, SH
Rodriguez, V
Brown, M
Toretsky, J
Khanna, C
Paige, M
Uren, A
AF Kosturko, George W.
Bulut, Gulay
Hong, Sung-Hyeok
Rodriguez, Veronica
Brown, Milton
Toretsky, Jeffrey
Khanna, Chand
Paige, Mikell
Uren, Aykut
TI Design, synthesis and biological evaluation of 2nd generation ezrin
inhibitors for metastatic osteosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kosturko, George W.; Bulut, Gulay; Hong, Sung-Hyeok; Rodriguez, Veronica; Brown, Milton; Toretsky, Jeffrey; Paige, Mikell; Uren, Aykut] Lombardi Comprehens Canc Ctr, Washington, DC USA.
[Khanna, Chand] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3906
DI 10.1158/1538-7445.AM2012-3906
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600011
ER
PT J
AU Truong, K
Gouveia, C
Coupar, J
Smyth, T
Lyons, J
Chen, Z
Van Waes, C
AF Kristy Truong
Gouveia, Christopher
Coupar, Jamie
Smyth, Tomoko
Lyons, John
Chen, Zhong
Van Waes, Carter
TI Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in
head and neck squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kristy Truong; Gouveia, Christopher; Coupar, Jamie; Chen, Zhong; Van Waes, Carter] NIH, Bethesda, MD 20892 USA.
[Smyth, Tomoko; Lyons, John] Astex Pharmaceut, Dublin, CA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2770
DI 10.1158/1538-7445.AM2012-2770
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603250
ER
PT J
AU Kwon, HC
Kim, SH
Oh, SY
Lee, S
Lee, JH
Graves, CA
Hwang, JA
Hong, SH
Kim, HJ
Camphausen, K
Lee, YS
AF Kwon, Hyuk-Chan
Kim, Sung-Hyun
Oh, Sung Yong
Lee, Suee
Lee, Ji Hyun
Graves, Christian A.
Hwang, Jung-Ah
Hong, Seung Hyun
Kim, Hyo-Jin
Camphausen, Kevin
Lee, Yeon-Su
TI Vascular endothelial growth factor gene polymorphisms and clinical
outcome in advanced gastric cancer treated with FOLFOX
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Kwon, Hyuk-Chan; Kim, Sung-Hyun; Oh, Sung Yong; Lee, Suee; Lee, Ji Hyun; Kim, Hyo-Jin] Dong A Univ, Med Ctr, Busan, South Korea.
[Graves, Christian A.; Camphausen, Kevin] NCI, Bethesda, MD 20892 USA.
[Hwang, Jung-Ah; Hong, Seung Hyun; Lee, Yeon-Su] Natl Canc Ctr, Goyang, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4539
DI 10.1158/1538-7445.AM2012-4539
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601029
ER
PT J
AU Laiyemo, AO
Doubeni, C
Adebogun, AO
McDonald-Pinkett, S
Han, P
Meissner, HI
Klabunde, C
AF Laiyemo, Adeyinka O.
Doubeni, Chyke
Adebogun, Akeem O.
McDonald-Pinkett, Shelly
Han, Paul
Meissner, Helen I.
Klabunde, Carrie
TI Colorectal cancer screening among US adults with and without doctor's
specific recommendation regarding choice of screening modality
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Laiyemo, Adeyinka O.; Adebogun, Akeem O.; McDonald-Pinkett, Shelly] Howard Univ, Washington, DC 20059 USA.
[Doubeni, Chyke] Univ Massachusetts, Massachusetts, MA USA.
[Han, Paul] Maine Med Ctr Res Inst, Maine, ME USA.
[Meissner, Helen I.] NIH, Bethesda, MD 20892 USA.
[Klabunde, Carrie] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3565
DI 10.1158/1538-7445.AM2012-3565
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503218
ER
PT J
AU Lam, TK
AF Lam, Tram K.
TI Influence of quercetin-rich foods intake on microRNA expression in EAGLE
lung cancer tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lam, Tram K.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2647
DI 10.1158/1538-7445.AM2012-2647
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602276
ER
PT J
AU Lee, JM
Hays, J
Annunziata, CM
Minasian, L
Zujewski, J
Squires, J
Nielsen, D
Houston, N
Moorshead, D
Cedillo, M
Kohn, EC
AF Lee, Jung-min
Hays, John
Annunziata, Christina M.
Minasian, Lori
Zujewski, JoAnne
Squires, Jennifer
Nielsen, Deborah
Houston, Nicole
Moorshead, David
Cedillo, Mario
Kohn, Elise C.
TI A pharmacokinetics/pharmacodynamics study of sequence specificity of the
PARP inhibitor, olaparib (O) with carboplatin (C) in recurrent women's
cancers NCT01237067
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lee, Jung-min; Hays, John; Annunziata, Christina M.; Minasian, Lori; Zujewski, JoAnne; Squires, Jennifer; Nielsen, Deborah; Houston, Nicole; Moorshead, David; Cedillo, Mario; Kohn, Elise C.] NCI, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1754
DI 10.1158/1538-7445.AM2012-1754
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601459
ER
PT J
AU Lee, M
Gildea, D
Trivedi, N
Wolfsberg, T
Crawford, NP
AF Lee, Minnkyong
Gildea, Derek
Trivedi, Niraj
Wolfsberg, Tyra
Crawford, Nigel P.
TI RRP1B, a novel metastasis suppressor, interacts with mRNA splicing
factors and regulates alternative mRNA splicing
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lee, Minnkyong; Gildea, Derek; Trivedi, Niraj; Wolfsberg, Tyra; Crawford, Nigel P.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3423
DI 10.1158/1538-7445.AM2012-3423
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504052
ER
PT J
AU Lee, YH
Bottaro, DP
AF Lee, Young H.
Bottaro, Donald P.
TI Integration of HGF/Met signaling and hypoxia response in cancer cell
invasion and proliferation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lee, Young H.; Bottaro, Donald P.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1225
DI 10.1158/1538-7445.AM2012-1225
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501395
ER
PT J
AU Leeman-Neilli, RJ
Brenner, AV
Little, MP
Bouville, AC
Bogdanova, TI
Hatch, M
Mabuchi, K
Tronko, MD
Nikiforov, YE
AF Leeman-Neilli, Rebecca J.
Brenner, Alina V.
Little, Mark P.
Bouville, Andre C.
Bogdanova, Tetyana I.
Hatch, Maureen
Mabuchi, Kiyohiko
Tronko, Mykola D.
Nikiforov, Yuri E.
TI Associations between RET/PTC rearrangements, BRAF and RAS mutations and
radiation dose, age at exposure, and latency in post-Chernobyl thyroid
cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Leeman-Neilli, Rebecca J.; Nikiforov, Yuri E.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
[Brenner, Alina V.; Little, Mark P.; Bouville, Andre C.; Hatch, Maureen; Mabuchi, Kiyohiko] NIH, Bethesda, MD 20892 USA.
[Bogdanova, Tetyana I.] Inst Endocrinol & Metab, Kiev, Ukraine.
[Tronko, Mykola D.] Kiev Univ, Kiev, Ukraine.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2544
DI 10.1158/1538-7445.AM2012-2544
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600234
ER
PT J
AU Li, HZ
Liu, WL
Rodriguez-Canales, J
Zhu, JQ
Hanson, JC
Emmert-Buck, MR
Deng, CX
Rodgers, GP
AF Li, Hongzhen
Liu, Wenli
Rodriguez-Canales, Jaime
Zhu, Jianqiong
Hanson, Jeffrey C.
Emmert-Buck, Michael R.
Deng, Chu-Xia
Rodgers, Griffin P.
TI Olfactomedin 4 gene is associated with progression of prostate cancer:
Evidence from an OLFM4 knockout mouse model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Li, Hongzhen; Liu, Wenli; Zhu, Jianqiong; Rodgers, Griffin P.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Rodriguez-Canales, Jaime; Hanson, Jeffrey C.; Emmert-Buck, Michael R.] NCI, NIH, Bethesda, MD 20892 USA.
[Deng, Chu-Xia] NIDDK, NIH, Bethesda, MD 20892 USA.
RI deng, chuxia/N-6713-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2695
DI 10.1158/1538-7445.AM2012-2695
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601335
ER
PT J
AU Li, SW
Liu, Y
Wang, JA
Moss, J
Darling, TN
AF Li, Shaowei
Liu, Ying
Wang, Ji-an
Moss, Joel
Darling, Thomas N.
TI Increased cathepsin B expression in cultured tuberous sclerosis skin
tumor cells and patient tumor tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Li, Shaowei; Liu, Ying; Wang, Ji-an; Darling, Thomas N.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Moss, Joel] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2469
DI 10.1158/1538-7445.AM2012-2469
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701506001
ER
PT J
AU Li, Y
Kim, DJ
Ma, WY
Lubet, R
Bode, AM
Dong, ZG
AF Li, Yan
Kim, Dong Joon
Ma, Weiya
Lubet, Ronald
Bode, Ann M.
Dong, Zigang
TI Discovery of novel checkpoint kinase 1 inhibitors by virtual screening
based on multiple crystal structures
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Li, Yan; Kim, Dong Joon; Ma, Weiya; Bode, Ann M.; Dong, Zigang] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA.
[Lubet, Ronald] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4780
DI 10.1158/1538-7445.AM2012-4780
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600039
ER
PT J
AU Li, Y
Linnoila, I
AF Li, Yan
Linnoila, Ilona
TI Achaete-scute homolog 1 (Ascl1) lineage in the lung gives rise to
multiple cell types
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Li, Yan; Linnoila, Ilona] NCI, Expt Pathol Sect, Cell & Canc Biol Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1308
DI 10.1158/1538-7445.AM2012-1308
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502414
ER
PT J
AU Li, ZB
Liu, SL
Hassink, M
Selvaraj, R
Yap, LP
Chen, XY
Fox, JM
Conti, PS
AF Li, Zibo
Liu, Shuanglong
Hassink, Matt
Selvaraj, Ramajeyam
Yap, Li-peng
Chen, Xiaoyuan
Fox, Joseph M.
Conti, Peter S.
TI Tetrazine trans-cyclooctene ligation: An efficient F-18 labeling method
for cysteine containing peptides and proteins
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Li, Zibo; Liu, Shuanglong; Yap, Li-peng; Conti, Peter S.] USC, Los Angeles, CA USA.
[Hassink, Matt; Selvaraj, Ramajeyam; Fox, Joseph M.] Univ Delaware, Delaware, DE USA.
[Chen, Xiaoyuan] NIBIB, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 370
DI 10.1158/1538-7445.AM2012-370
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505407
ER
PT J
AU Lim, KP
Gan, CP
Chong, CE
Zain, RB
Abraham, MT
Rahman, ZAA
Teo, SH
Gutkind, JS
Patel, V
Ponniah, S
Cheong, SC
AF Lim, Kue Peng
Gan, Chai Phei
Chong, Chan Eng
Zain, Rosnah Binti
Abraham, Mannil Thomas
Rahman, Zainal Ariff Abdul
Teo, Soo-Hwang
Gutkind, J. Silvio
Patel, Vyomesh
Ponniah, Sathibalan
Cheong, Sok Ching
TI MAGED4B drives oral carcinogenesis and is a promising peptide vaccine
target for the treatment of oral squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lim, Kue Peng; Gan, Chai Phei; Chong, Chan Eng; Teo, Soo-Hwang] Canc Res Initiat Fdn, Subang Jaya, Malaysia.
[Zain, Rosnah Binti; Rahman, Zainal Ariff Abdul; Cheong, Sok Ching] Univ Malaya, Kuala Lumpur, Malaysia.
[Abraham, Mannil Thomas] Minist Hlth, Kuala Lumpur, Malaysia.
[Gutkind, J. Silvio; Patel, Vyomesh] NIH, Bethesda, MD 20892 USA.
[Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1573
DI 10.1158/1538-7445.AM2012-1573
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501014
ER
PT J
AU Lin, SW
Freedman, ND
Hu, N
Tang, ZZ
Wang, LM
Wang, CY
Ding, T
Wang, Y
Fan, JH
Qiao, YL
Wheeler, W
Yu, K
Goldstein, AM
Dawsey, SM
Taylor, PR
Abnet, CC
AF Lin, Shih-Wen
Freedman, Neal D.
Hu, Nan
Tang, Ze-Zhong
Wang, Lemin
Wang, Chaoyu
Ding, Ti
Wang, Yuan
Fan, Jin-Hu
Qiao, You-Lin
Wheeler, William
Yu, Kai
Goldstein, Alisa M.
Dawsey, Sanford M.
Taylor, Philip R.
Abnet, Christian C.
TI Genetic variants of iron-dependent metabolism genes and risk of upper
gastrointestinal cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lin, Shih-Wen; Freedman, Neal D.; Hu, Nan; Wang, Lemin; Wang, Chaoyu; Yu, Kai; Goldstein, Alisa M.; Dawsey, Sanford M.; Taylor, Philip R.; Abnet, Christian C.] NCI, NIH, Bethesda, MD 20892 USA.
[Tang, Ze-Zhong; Ding, Ti; Wang, Yuan] Shanxi Canc Hosp & Inst, Taiyuan, Peoples R China.
[Fan, Jin-Hu; Qiao, You-Lin] Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China.
[Wheeler, William] lnformat Management Serv Inc, Silver Spring, MD USA.
RI Qiao, You-Lin/B-4139-2012
OI Qiao, You-Lin/0000-0001-6380-0871
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2632
DI 10.1158/1538-7445.AM2012-2632
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602260
ER
PT J
AU Lin, TL
Lee, DW
Kochenderfer, JN
Mackall, CL
AF Lin, Tasha L.
Lee, Daniel W.
Kochenderfer, James N.
Mackall, Crystal L.
TI Short-term cytolytic assays are not predictive of chimeric antigen
receptor anti-tumor activity mediated by some T cell subsets
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Lin, Tasha L.; Lee, Daniel W.; Kochenderfer, James N.; Mackall, Crystal L.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3502
DI 10.1158/1538-7445.AM2012-3502
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500375
ER
PT J
AU Liu, T
Shi, TJ
Hossain, M
Schepmoes, A
Fillmore, T
Sokoll, LJ
Chan, D
Leach, R
Thompson, I
Smith, RD
Kagan, J
Srivastava, S
Rodland, KD
Camp, DG
Qian, WJ
AF Liu, Tao
Shi, Tujin
Hossain, Mahmud
Schepmoes, Athena
Fillmore, Thomas
Sokoll, Lori J.
Chan, Daniel
Leach, Robin
Thompson, Ian
Smith, Richard D.
Kagan, Jacob
Srivastava, Sudhir
Rodland, Karin D.
Camp, David G.
Qian, Wei-Jun
TI Accurate measurement of serum total and free PSA using immunoaffinity
depletion coupled to SRM: Correlation with clinical immunoassays
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Liu, Tao; Shi, Tujin; Hossain, Mahmud; Schepmoes, Athena; Fillmore, Thomas; Smith, Richard D.; Rodland, Karin D.; Camp, David G.; Qian, Wei-Jun] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Sokoll, Lori J.; Chan, Daniel] Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
[Leach, Robin; Thompson, Ian] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Kagan, Jacob; Srivastava, Sudhir] NCI, Rockville, MD USA.
RI Smith, Richard/J-3664-2012
OI Smith, Richard/0000-0002-2381-2349
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1268
DI 10.1158/1538-7445.AM2012-1268
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502371
ER
PT J
AU Luhn, P
Sherman, M
Killian, K
Adams, L
Stevenson, H
Meltzer, P
D'Ambrosio, L
Hewitt, SM
Guido, R
Wentzensen, N
AF Luhn, Patricia
Sherman, Mark
Killian, Keith
Adams, Lisa
Stevenson, Holly
Meltzer, Paul
D'Ambrosio, Lori
Hewitt, Stephen M.
Guido, Richard
Wentzensen, Nicolas
TI Association of endometrial cancer risk factors and DNA methylation in
benign endometrial tissue
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Luhn, Patricia; Sherman, Mark; Wentzensen, Nicolas] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Killian, Keith; Adams, Lisa; Stevenson, Holly; Meltzer, Paul] NCI, Genet Branch, Ctr Canc Res, Rockville, MD USA.
[D'Ambrosio, Lori; Guido, Richard] Magee Womens Hosp, Dept Obstet & Gynecol, Pittsburgh, PA USA.
[Hewitt, Stephen M.] NCI, Appl Mol Pathol Lab, Pathol Lab, Ctr Canc Res, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4475
DI 10.1158/1538-7445.AM2012-4475
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603424
ER
PT J
AU Ma, YW
Gupta, V
Trieu, R
Lap, LT
Kaipparettu, BA
Wong, LJ
AF Ma, Yewei
Gupta, Vineet
Trieu, Robert
Lap, Lee Tin
Kaipparettu, Benny A.
Wong, Lee-Jun
TI Oncogenic potential of mitochondria regulate the cellular tumor
characteristics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ma, Yewei; Gupta, Vineet; Trieu, Robert; Kaipparettu, Benny A.; Wong, Lee-Jun] Baylor Coll Med, Houston, TX 77030 USA.
[Lap, Lee Tin] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 998
DI 10.1158/1538-7445.AM2012-998
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501126
ER
PT J
AU Mancini, M
Fer, N
Perez, V
Teicher, B
Rapisarda, A
AF Mancini, Monica
Fer, Nicole
Perez, Victor
Teicher, Beverly
Rapisarda, Annamaria
TI Interleukin 11: A novel therapeutic target in IL-11R alpha expressing
sarcomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mancini, Monica; Fer, Nicole; Perez, Victor; Teicher, Beverly; Rapisarda, Annamaria] NCI Frederick, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 890
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604047
ER
PT J
AU Marincola, FM
Wang, E
AF Marincola, Francesco M.
Wang, Ena
TI The immunologic constant of rejection and cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Marincola, Francesco M.; Wang, Ena] NIH CC, Bethesda, MD USA.
[Marincola, Francesco M.; Wang, Ena] Trans NIH Ctr Human Immunol, Bethesda, MD USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA SY32-01
DI 10.1158/1538-7445.AM2012-SY32-01
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500214
ER
PT J
AU Marino, N
Marshall, JCA
Collins, J
Zhou, M
Veenstra, T
Steeg, PS
AF Marino, Natascia
Marshall, Jean-Claude A.
Collins, Joshua
Zhou, Ming
Veenstra, Timothy
Steeg, Patricia S.
TI Interaction of two metastasis suppressors, Nm23-H1 and Gelsolin, in the
proliferation and motility of MDA-MB-231 breast carcinoma cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Marino, Natascia; Marshall, Jean-Claude A.; Collins, Joshua; Steeg, Patricia S.] NCI, Bethesda, MD 20892 USA.
[Zhou, Ming; Veenstra, Timothy] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3427
DI 10.1158/1538-7445.AM2012-3427
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504056
ER
PT J
AU Marrero, AM
Lawrence, SM
Balasubramanian, P
Pommier, YG
Tomaszewski, JE
Parchment, RE
Doroshow, JH
Kinders, RJ
AF Marrero, Allison M.
Lawrence, Scott M.
Balasubramanian, Priya
Pommier, Yves G.
Tomaszewski, Joseph E.
Parchment, Ralph E.
Doroshow, James H.
Kinders, Robert J.
TI A multiplex quantitative immunofluorescence assay for DNA damage repair
in response to cytotoxic treatment
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Marrero, Allison M.; Lawrence, Scott M.; Balasubramanian, Priya; Parchment, Ralph E.; Kinders, Robert J.] NCI Frederick, Lab Human Toxicol & Pharmacol, Appl Dev Directorate, SAIC Frederick Inc, Frederick, MD USA.
[Pommier, Yves G.] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3620
DI 10.1158/1538-7445.AM2012-3620
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600387
ER
PT J
AU Marshall, JCA
Collins, J
Zhou, M
Veenstra, T
Khanna, C
Steeg, P
AF Marshall, Jean-Claude A.
Collins, Joshua
Zhou, Ming
Veenstra, Timothy
Khanna, Chand
Steeg, Patricia
TI Nm23, a metastasis suppressor gene, binds the cytoskeletal linker Ezrin
to regulate motility
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Marshall, Jean-Claude A.; Collins, Joshua; Zhou, Ming; Veenstra, Timothy; Khanna, Chand; Steeg, Patricia] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3421
DI 10.1158/1538-7445.AM2012-3421
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504049
ER
PT J
AU Matthews, CE
Sampson, J
Keadle, S
Freedson, P
Lyden, K
Libertine, A
Fowke, JH
AF Matthews, Charles E.
Sampson, Joashua
Keadle, Sarah
Freedson, Patty
Lyden, Kate
Libertine, Amanda
Fowke, Jay H.
TI Evaluation of the performance of a previous day recall of time spent in
active and sedentary behaviors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Matthews, Charles E.; Sampson, Joashua] NCI, Bethesda, MD 20892 USA.
[Keadle, Sarah; Freedson, Patty; Lyden, Kate; Libertine, Amanda] Univ Massachusetts, Amherst, MA 01003 USA.
[Fowke, Jay H.] Vanderbilt Univ, Nashville, TN 37235 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4459
DI 10.1158/1538-7445.AM2012-4459
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503248
ER
PT J
AU McCollum, AK
Angelos, MG
Fischione, AD
Mineo, M
Kohn, EC
AF McCollum, Andrea K.
Angelos, Mathew G.
Fischione, Andrea D.
Mineo, Marco
Kohn, Elise C.
TI A novel function of WW domain binding protein 2 (WBP2) in regulating
cytoskeletal function and cellular division through binding to
co-chaperone BAG3
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [McCollum, Andrea K.; Angelos, Mathew G.; Fischione, Andrea D.; Mineo, Marco; Kohn, Elise C.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2032
DI 10.1158/1538-7445.AM2012-2032
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604297
ER
PT J
AU McCully, CM
Pastakia, D
Bacher, J
Thomas, M
Steffen-Smith, E
Saleem, K
Walbridge, S
Brinster, L
Warren, K
AF McCully, Cynthia M.
Pastakia, Devang
Bacher, John
Thomas, Marvin
Steffen-Smith, Emilie
Saleem, Kadharbatcha
Walbridge, Stuart
Brinster, Lauren
Warren, Katherine
TI Development of an animal model for microdialysis sampling of pons and
cerebral cortex in rhesus macaques
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [McCully, Cynthia M.; Pastakia, Devang; Steffen-Smith, Emilie; Warren, Katherine] NCI, Bethesda, MD 20892 USA.
[Bacher, John; Thomas, Marvin; Brinster, Lauren] Off Res Serv, Bethesda, MD USA.
[Saleem, Kadharbatcha] NIMH, Bethesda, MD 20892 USA.
[Walbridge, Stuart] NINDS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3789
DI 10.1158/1538-7445.AM2012-3789
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501319
ER
PT J
AU McGlynn, KA
Chia, VM
Trabert, B
Cook, MB
Quraishi, S
Stanczyk, FZ
Rifai, N
Bradwin, G
Rubertone, MV
Graubard, BI
Erickson, RL
AF McGlynn, Katherine A.
Chia, Victoria M.
Trabert, Britton
Cook, Michael B.
Quraishi, Sabah
Stanczyk, Frank Z.
Rifai, Nader
Bradwin, Gary
Rubertone, Mark V.
Graubard, Barry I.
Erickson, Ralph L.
TI Pre-diagnostic steroid hormone levels and risk of testicular germ cell
tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [McGlynn, Katherine A.; Chia, Victoria M.; Trabert, Britton; Cook, Michael B.; Quraishi, Sabah; Graubard, Barry I.] NCI, Bethesda, MD 20892 USA.
[Stanczyk, Frank Z.] Univ So Calif, Los Angeles, CA USA.
[Rifai, Nader; Bradwin, Gary] Childrens Hosp Boston, Boston, MA USA.
[Rubertone, Mark V.] Dept Def Serum Repository, Silver Spring, MD USA.
[Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4468
DI 10.1158/1538-7445.AM2012-4468
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603346
ER
PT J
AU McMaster, ML
Heimdal, KR
Greene, MH
AF McMaster, Mary L.
Heimdal, Ketil R.
Greene, Mark H.
TI No evidence for increased risk of cancers other than testicular cancer
among first-degree relatives of testicular germ cell tumor (TGCT)
patients from multiple-case TGCT families
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [McMaster, Mary L.; Greene, Mark H.] NCI, DCEG, Bethesda, MD 20892 USA.
[Heimdal, Ketil R.] Oslo Univ Hosp, Oslo, Norway.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2644
DI 10.1158/1538-7445.AM2012-2644
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602273
ER
PT J
AU Melenhorst, JJ
McIyer, ZA
Zheng, HY
Wu, CO
Grim, A
Ito, S
Cho, I
Hensel, NF
Barrett, AJ
AF Melenhorst, Jan J.
McIyer, Zachariah A.
Zheng, Haiyun
Wu, Colin O.
Grim, Andrew
Ito, Sawa
Cho, Irene
Hensel, Nancy F.
Barrett, Austin John
TI Low donor thymic output predicts increased incidence of extensive
chronic GVHD and worse overall survival after TCD-matched sibling SCT
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Melenhorst, Jan J.; McIyer, Zachariah A.; Zheng, Haiyun; Wu, Colin O.; Grim, Andrew; Ito, Sawa; Cho, Irene; Hensel, Nancy F.; Barrett, Austin John] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5377
DI 10.1158/1538-7445.AM2012-5377
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500298
ER
PT J
AU Meshinchi, S
Ries, RE
Farrar, J
Auvil, JG
Davidsen, TM
Gesuwan, P
Trevino, LR
Muzny, DM
Wheeler, DA
Gamis, AS
Alonzo, TA
Smith, MA
Gerhard, DS
Arceci, RJ
AF Meshinchi, Soheil
Ries, Rhonda E.
Farrar, Jason
Auvil, Jaime Guidry
Davidsen, Tanja M.
Gesuwan, Patee
Trevino, Lisa R.
Muzny, Donna M.
Wheeler, David A.
Gamis, Alan S.
Alonzo, Todd A.
Smith, Malcolm A.
Gerhard, Daniela S.
Arceci, Robert J.
TI Demonstration of significant clonal evolution from diagnosis to relapse
in childhood AML determined by exome capture sequencing: an NCI/COG
TARGET AML study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Meshinchi, Soheil; Ries, Rhonda E.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Farrar, Jason; Arceci, Robert J.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
[Auvil, Jaime Guidry; Davidsen, Tanja M.; Gesuwan, Patee; Smith, Malcolm A.; Gerhard, Daniela S.] NCI, Bethesda, MD 20892 USA.
[Trevino, Lisa R.; Muzny, Donna M.; Wheeler, David A.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
[Gamis, Alan S.] Childrens Mercy Hosp & Clin, Kansas City, MO USA.
[Alonzo, Todd A.] Univ So Calif, Los Angeles, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-93
DI 10.1158/1538-7445.AM2012-LB-93
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604189
ER
PT J
AU Michalowski, AM
Simmons, JK
Patel, J
Kuehl, WM
Zhang, SL
Landgren, O
Mock, BA
AF Michalowski, Aleksandra M.
Simmons, John K.
Patel, Jyoti
Kuehl, W. Michael
Zhang, Shuling
Landgren, Ola
Mock, Beverly A.
TI Genes cooperatively downregulated by combined mTOR/histone deactylase
(HDAC) inhibition are overexpressed in myeloma patients with lower
survival
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Michalowski, Aleksandra M.; Simmons, John K.; Patel, Jyoti; Kuehl, W. Michael; Zhang, Shuling; Landgren, Ola; Mock, Beverly A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4734
DI 10.1158/1538-7445.AM2012-4734
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604032
ER
PT J
AU Miller, PE
Lazarus, P
Lesko, SM
Cross, AJ
Sinha, R
Laio, J
Zhu, J
Harper, G
Muscat, JE
Hartman, TJ
AF Miller, Paige E.
Lazarus, Philip
Lesko, Samuel M.
Cross, Amanda J.
Sinha, Rashmi
Laio, Jason
Zhu, Jay
Harper, Gregory
Muscat, Joshua E.
Hartman, Terryl J.
TI Meat-related compounds and colorectal cancer risk by anatomical subsite
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Miller, Paige E.] NCI, Rockville, MD USA.
[Lazarus, Philip; Laio, Jason; Zhu, Jay; Muscat, Joshua E.] Penn State Coll Med, Hershey, PA USA.
[Lesko, Samuel M.] Northeast Reg Canc Inst, Scranton, PA USA.
[Cross, Amanda J.; Sinha, Rashmi] NCI, Bethesda, MD 20892 USA.
[Harper, Gregory] Morgan Canc Ctr, Allentown, PA USA.
[Hartman, Terryl J.] Penn State Univ, University Pk, PA 16802 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4460A
DI 10.1158/1538-7445.AM2012-4460A
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503251
ER
PT J
AU Mineo, M
Taverna, S
Flugy, A
De Leo, G
Alessandro, R
Kohn, EC
AF Mineo, Marco
Taverna, Simona
Flugy, Anna
De Leo, Giacomo
Alessandro, Riccardo
Kohn, Elise C.
TI Chronic myeloid leukemia (CML) exosomes promote angiogenesis in a
Src-dependent fashion in vitro and in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mineo, Marco; Kohn, Elise C.] NCI, Mol Signaling Sect, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Taverna, Simona; Flugy, Anna; De Leo, Giacomo; Alessandro, Riccardo] Univ Palermo, Dipartimento Biopatol & Biotecnol Med & Forensi, Sez Biol & Genet, Palermo, Italy.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4372
DI 10.1158/1538-7445.AM2012-4372
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502138
ER
PT J
AU Mirabello, L
Chung, C
Yeager, MM
Savage, SA
AF Mirabello, Lisa
Chung, Charles
Yeager, Meredith M.
Savage, Sharon A.
TI Understanding cancer associated SNPs in the TERT-CLPTM1L locus through
population genetics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mirabello, Lisa; Savage, Sharon A.] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA.
[Chung, Charles; Yeager, Meredith M.] NCI, Core Genotyping Facil, DCEG, SAIC Frederick Inc, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1668
DI 10.1158/1538-7445.AM2012-1668
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602216
ER
PT J
AU Mischo, A
Harter, P
Mueller, K
Kleber, S
Zachskorn, C
Renner, C
Steeg, PS
Mittelbronn, M
Pestalozzi, BC
AF Mischo, Axel
Harter, Patrick
Mueller, Klaus
Kleber, Sascha
Zachskorn, Cornelia
Renner, Christoph
Steeg, Patricia S.
Mittelbronn, Michel
Pestalozzi, Bernhard C.
TI Docetaxel pretreatment is associated with increased incidence of
CNS-metastases in a murine model of HER2-positive breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mischo, Axel; Kleber, Sascha; Renner, Christoph; Pestalozzi, Bernhard C.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
[Harter, Patrick; Mueller, Klaus; Zachskorn, Cornelia; Mittelbronn, Michel] Edinger Inst, Neurol Inst, Frankfurt, Germany.
[Steeg, Patricia S.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1395
DI 10.1158/1538-7445.AM2012-1395
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503483
ER
PT J
AU Mishra, PJ
Guo, T
Zaidi, R
Davis, S
Arnheiter, H
Walker, RL
Meltzer, P
Merlino, G
AF Mishra, Pravin J.
Guo, Theresa
Zaidi, Raza
Davis, Sean
Arnheiter, Heinz
Walker, Robert L.
Meltzer, Paul
Merlino, Glenn
TI Using embryonic melanoblast transcriptome analysis to identify novel
mechanisms promoting metastatic melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Davis, Sean; Walker, Robert L.; Meltzer, Paul] NCI, Lab Canc Biol & Genet, NIH, Bethesda, MD 20892 USA.
[Arnheiter, Heinz] NINDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4856
DI 10.1158/1538-7445.AM2012-4856
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501120
ER
PT J
AU Mkrtichyan, M
Najjar, YG
Raulfs, EC
Liu, LD
Langerman, S
Khleif, SN
AF Mkrtichyan, Mikayel
Najjar, Yana G.
Raulfs, Estella C.
Liu, Linda
Langerman, Solomon
Khleif, Samir N.
TI PD-1 expression level on T cell subsets is a crucial factor forming a
novel mechanism for designing immune therapeutic approaches using PD-1
binding ligand
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mkrtichyan, Mikayel; Najjar, Yana G.; Raulfs, Estella C.; Khleif, Samir N.] NCI, NIH, Bethesda, MD 20892 USA.
[Liu, Linda; Langerman, Solomon] Amplimmune Inc, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-491
DI 10.1158/1538-7445.AM2012-LB-491
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504245
ER
PT J
AU Mohammed, A
Janakiram, NB
Brewer, M
Biddick, L
Lighffoot, S
Steele, VE
Rao, CV
AF Mohammed, Altaf
Janakiram, Naveena B.
Brewer, Misty
Biddick, Laura
Lighffoot, Stan
Steele, Vernon E.
Rao, Chinthalapally V.
TI Targeting COX-LOX and EGFR pathways simultaneously by licofelone and
gefitinib lead to complete blockade of progression of PanINs to
pancreatic ductal adenocarcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mohammed, Altaf; Janakiram, Naveena B.; Brewer, Misty; Biddick, Laura; Lighffoot, Stan; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
[Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1005
DI 10.1158/1538-7445.AM2012-1005
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503178
ER
PT J
AU Moiola, CP
De Luca, P
Zalazar, F
Cotignola, J
Gardner, K
Vazquez, E
De Siervi, A
AF Moiola, Cristian P.
De Luca, Paola
Zalazar, Florencia
Cotignola, Javier
Gardner, Kevin
Vazquez, Elba
De Siervi, Adriana
TI ATM transcriptional regulation mediated by BRCA1/E2F1 axis controls DNA
damage response in prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Moiola, Cristian P.; De Luca, Paola; Zalazar, Florencia; Cotignola, Javier; Vazquez, Elba; De Siervi, Adriana] Univ Buenos Aires, Dept Biol Chem, Buenos Aires, DF, Argentina.
[Gardner, Kevin] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1312
DI 10.1158/1538-7445.AM2012-1312
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502419
ER
PT J
AU Mondul, AM
Weinstein, SJ
Bosworth, T
Remaley, AT
Virtamo, J
Albanes, D
AF Mondul, Alison M.
Weinstein, Stephanie J.
Bosworth, Tracey
Remaley, Alan T.
Virtamo, Jarmo
Albanes, Demetrius
TI Circulating thyroxine (T4), thyroid-stimulating hormone (TSH), and
hypothyroid status and the risk of prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Mondul, Alison M.; Weinstein, Stephanie J.; Albanes, Demetrius] NCI, DCEG, Rockville, MD USA.
[Bosworth, Tracey; Remaley, Alan T.] NCI, Ctr Clin, Bethesda, MD 20892 USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki, Finland.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4472
DI 10.1158/1538-7445.AM2012-4472
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603390
ER
PT J
AU Monks, A
Hose, CD
Hayete, B
Runge, K
DeCaprio, D
Teicher, BA
Khalil, I
McDonaugh, P
Doroshow, JH
AF Monks, Anne
Hose, Curtis D.
Hayete, Boris
Runge, Karl
DeCaprio, David
Teicher, Beverley A.
Khalil, Iya
McDonaugh, Paul
Doroshow, James H.
TI Confirmation of peroxiredoxin II as a driver gene for doxorubicin
sensitivity identified from drug-induced expression profiling of the
NCI-60 cell lines using Reverse Engineering (REFS) network models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Monks, Anne; Hose, Curtis D.] NCI, Frederick, MD 21701 USA.
[Hayete, Boris; Runge, Karl; DeCaprio, David; Khalil, Iya; McDonaugh, Paul] GNS Healthcare, Cambridge, MA USA.
[Teicher, Beverley A.; Doroshow, James H.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5663
DI 10.1158/1538-7445.AM2012-5663
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603488
ER
PT J
AU Montrose, DC
Kopelovich, L
Zhou, XK
Yantiss, R
Subbaramaiah, K
Dannenberg, A
AF Montrose, David C.
Kopelovich, Levy
Zhou, Xi Kathy
Yantiss, Rhonda
Subbaramaiah, Kotha
Dannenberg, Andrew
TI Metabolomic profiling for early detection of colorectal neoplasia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Montrose, David C.; Zhou, Xi Kathy; Yantiss, Rhonda; Subbaramaiah, Kotha; Dannenberg, Andrew] Weill Cornell Med Coll, New York, NY USA.
[Kopelovich, Levy] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1634
DI 10.1158/1538-7445.AM2012-1634
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503372
ER
PT J
AU Moody, TW
Mantey, S
Jensen, RT
Wink, D
Mukhopadhyay, P
Pacher, P
AF Moody, Terry W.
Mantey, Samuel
Jensen, Robert T.
Wink, David
Mukhopadhyay, Partha
Pacher, Pal
TI Cannabinoids inhibit epidermal growth factor receptor transactivation in
lung cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Moody, Terry W.; Wink, David] NCI, CCR, Bethesda, MD 20892 USA.
[Mantey, Samuel; Jensen, Robert T.] NIDDK, Bethesda, MD 20892 USA.
[Mukhopadhyay, Partha; Pacher, Pal] NIAAA, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1091
DI 10.1158/1538-7445.AM2012-1091
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605458
ER
PT J
AU Moon, SY
Bilke, S
Davis, S
Walker, RL
Pineda, M
Zhu, YJ
Abaan, O
Meltzer, PS
AF Moon, So Young
Bilke, Sven
Davis, Sean
Walker, Robert L.
Pineda, Marbin
Zhu, Yuelin Jack
Abaan, Ogan
Meltzer, Paul S.
TI Paired-end RNA-sequencing reveals novel fusion genes and SNVs in
osteosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Moon, So Young; Bilke, Sven; Davis, Sean; Walker, Robert L.; Pineda, Marbin; Zhu, Yuelin Jack; Abaan, Ogan; Meltzer, Paul S.] NCI, NIH, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5070
DI 10.1158/1538-7445.AM2012-5070
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606274
ER
PT J
AU Morrison, BL
Bernal, F
AF Morrison, Bethanie L.
Bernal, Federico
TI Modulation of metastatic behavior in breast cancers harboring p53
mutations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Morrison, Bethanie L.; Bernal, Federico] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4329
DI 10.1158/1538-7445.AM2012-4329
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501438
ER
PT J
AU Morrow, JJ
Briggs, J
Ren, L
Chakrabarti, K
Cassavaugh, J
Veenstra, TD
Chen, QR
Khan, J
Uren, A
Khanna, C
AF Morrow, James J.
Briggs, Joseph
Ren, Ling
Chakrabarti, Kristi
Cassavaugh, Jessica
Veenstra, Timothy D.
Chen, Qingrong
Khan, Javed
Uren, Aykut
Khanna, Chand
TI Ezrin plays a key role in the regulation of translation in metastatic
osteosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Morrow, James J.] NIH, Howard Hughes Med Inst, Bethesda, MD 20892 USA.
[Briggs, Joseph; Ren, Ling; Chakrabarti, Kristi; Cassavaugh, Jessica; Khanna, Chand] NCI, Tumor & Metastasis Biol Sect, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
[Veenstra, Timothy D.] NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA.
[Chen, Qingrong; Khan, Javed] NCI, Oncogen Sect, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
[Uren, Aykut] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4190
DI 10.1158/1538-7445.AM2012-4190
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502427
ER
PT J
AU Murthy, SRK
Lee, TK
Cawley, NX
Hewitt, SM
Pacak, K
Loh, P
AF Murthy, Saravana R. K.
Lee, Terence K.
Cawley, Niamh X.
Hewitt, Stephen M.
Pacak, Karel
Loh, Peng
TI An N-terminal truncated carboxypeptidase E splice isoform induces
metastasis by activating nedd9 and other metastasis inducing genes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Murthy, Saravana R. K.; Cawley, Niamh X.; Pacak, Karel; Loh, Peng] NICHD, NIH, Bethesda, MD USA.
[Lee, Terence K.] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
[Hewitt, Stephen M.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5327
DI 10.1158/1538-7445.AM2012-5327
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504101
ER
PT J
AU Musselman, J
Bergemann, T
Krailo, M
Malkin, D
Ross, J
Savage, S
Nagarajan, R
Sklar, C
Spector, L
AF Musselman, Jessica
Bergemann, Tracy
Krailo, Mark
Malkin, David
Ross, Julie
Savage, Sharon
Nagarajan, Rajaram
Sklar, Charles
Spector, Logan
TI A case-parent-triad approach in assessing risk of osteosarcoma
associated with genetic variation in insulin-like growth factor 1/growth
hormone axis genes: a Children's Oncology Group (COG) study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Musselman, Jessica; Ross, Julie; Spector, Logan] Univ Minnesota, Minneapolis, MN USA.
[Bergemann, Tracy] Medtronic, Minneapolis, MN USA.
[Krailo, Mark] Univ So Calif, Los Angeles, CA USA.
[Malkin, David] Univ Toronto, Toronto, ON, Canada.
[Savage, Sharon] NCI, Washington, DC USA.
[Nagarajan, Rajaram] Univ Cincinnati, Cincinnati, OH USA.
[Sklar, Charles] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-333
DI 10.1158/1538-7445.AM2012-LB-333
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603191
ER
PT J
AU Myung, K
AF Myung, Kyungjae
TI High -throughput genotoxicity screening unlocks chemotherapeutic
potential of antioxidants
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Myung, Kyungjae] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2838
DI 10.1158/1538-7445.AM2012-2838
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604020
ER
PT J
AU Naing, A
LoRusso, P
Subbiah, V
Fu, SQ
Hong, D
Anderson, P
Benjamin, R
Ludwig, J
Chen, HX
Doyle, A
Kurzrock, R
AF Naing, Aung
LoRusso, Patricia
Subbiah, Vivek
Fu, Siqing
Hong, David
Anderson, Peter
Benjamin, Robert
Ludwig, Joseph
Chen, Helen X.
Doyle, Austin
Kurzrock, Razelle
TI Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined
with the mTOR inhibitor temsirolimus in patients with refractory Ewing's
sarcoma family tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Naing, Aung; Subbiah, Vivek; Fu, Siqing; Hong, David; Anderson, Peter; Benjamin, Robert; Ludwig, Joseph; Kurzrock, Razelle] UT MD Anderson Canc Ctr, Houston, TX USA.
[LoRusso, Patricia] Karmanos Canc Inst, Detroit, MI USA.
[Chen, Helen X.; Doyle, Austin] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-124
DI 10.1158/1538-7445.AM2012-LB-124
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601401
ER
PT J
AU Nasser, MW
Qamri, Z
Deol, YS
Ravi, J
Powell, CA
Trikha, P
Schwendener, RA
Shilo, K
Wolf, R
Yuspa, SH
Ganju, RK
AF Nasser, Mohd W.
Qamri, Zahida
Deol, Yadwinder S.
Ravi, Janani
Powell, Catherine A.
Trikha, Prashant
Schwendener, Reto A.
Shilo, Konstantin
Wolf, Ronald
Yuspa, Stuart H.
Ganju, Ramesh K.
TI mS100a7a15 enhances mammary tumor growth and metastasis by recruiting
tumor associated macrophages
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Nasser, Mohd W.; Qamri, Zahida; Deol, Yadwinder S.; Ravi, Janani; Powell, Catherine A.; Trikha, Prashant; Shilo, Konstantin; Ganju, Ramesh K.] Ohio State Univ, Columbus, OH 43210 USA.
[Schwendener, Reto A.] Univ Zurich, Zurich, Switzerland.
[Wolf, Ronald] Univ Munich, Munich, Germany.
[Yuspa, Stuart H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 388
DI 10.1158/1538-7445.AM2012-388
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505442
ER
PT J
AU Newton, DL
Stockwin, LH
Mullendore, ME
Han, BN
Morrison, BL
Borgel, S
Stotler, H
Fang, BL
Hollingshead, MG
AF Newton, Dianne L.
Stockwin, Luke H.
Mullendore, Michael E.
Han, Bingnan
Morrison, Bethanie L.
Borgel, Suzanne
Stotler, Howard
Fang, Bingliang
Hollingshead, Melinda G.
TI NSC 743380 induces apoptosis in sensitive cell lines through activation
of tyrosine kinase 2 (Tyk2)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Newton, Dianne L.; Stockwin, Luke H.; Mullendore, Michael E.; Han, Bingnan; Morrison, Bethanie L.] NCI, Drug Mech Grp, SAIC Frederick Inc, Frederick, MD 21701 USA.
[Borgel, Suzanne; Stotler, Howard] NCI, In Vivo Preclin Support Grp, SAIC Frederick Inc, Frederick, MD 21701 USA.
[Fang, Bingliang] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA.
[Hollingshead, Melinda G.] NCI, Biol Testing Branch, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2810
DI 10.1158/1538-7445.AM2012-2810
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603472
ER
PT J
AU Niedan, S
Kauer, M
Jug, G
Walker, RL
Meltzer, PS
Kontny, U
Kovar, H
AF Niedan, Stephan
Kauer, Max
Jug, Gunhild
Walker, Robert L.
Meltzer, Paul S.
Kontny, Udo
Kovar, Heinrich
TI Reactivation of EWS-FLI1 suppressed FOXO1 expression as a novel
therapeutic strategy for Ewing's sarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Niedan, Stephan; Kauer, Max; Jug, Gunhild; Kovar, Heinrich] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria.
[Walker, Robert L.; Meltzer, Paul S.] NCI, Genet Branch, Bethesda, MD USA.
[Kontny, Udo] Univ Freiburg Klinikum, Freiburg, Germany.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2961
DI 10.1158/1538-7445.AM2012-2961
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501142
ER
PT J
AU O'Konek, J
Takao, S
Izhak, L
Illarinov, P
Besra, G
Berzofsky, J
Terabe, M
AF O'Konek, Jessica
Takao, Satomi
Izhak, Liat
Illarinov, Petr
Besra, Gurdyal
Berzofsky, Jay
Terabe, Masaki
TI alpha-mannosylceramide, a new NKT cell agonist, induces tumor immunity
without anergy induction in NKT cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [O'Konek, Jessica; Takao, Satomi; Izhak, Liat; Berzofsky, Jay; Terabe, Masaki] NCI, Bethesda, MD 20892 USA.
[Illarinov, Petr; Besra, Gurdyal] Univ Birmingham, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1556
DI 10.1158/1538-7445.AM2012-1556
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500338
ER
PT J
AU Ou, O
Huppi, K
Gehlhaus, K
Jones, T
Caplen, N
AF Ou, Oliver
Huppi, Konrad
Gehlhaus, Kristen
Jones, Tamara
Caplen, Natasha
TI Large-scale RNAi screening of human kinome identifies putative breast
cancer related molecular targets
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ou, Oliver; Huppi, Konrad; Gehlhaus, Kristen; Jones, Tamara; Caplen, Natasha] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 267
DI 10.1158/1538-7445.AM2012-267
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502328
ER
PT J
AU Pantoja, DRS
Masaki, T
Ridnour, LA
DeGraff, W
Berzofsky, JA
Roberts, DD
AF Pantoja, David R. Soto
Masaki, Terabe
Ridnour, Lisa A.
DeGraff, William
Berzofsky, Jay A.
Roberts, David D.
TI Lack of CD47 in the tumor microenvironment enhances anti-tumor adaptive
immune responses when combined with ionizing radiation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Pantoja, David R. Soto; Masaki, Terabe; Ridnour, Lisa A.; DeGraff, William; Berzofsky, Jay A.; Roberts, David D.] NCI, NIH, Bethesda, MD 20892 USA.
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3451
DI 10.1158/1538-7445.AM2012-3451
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502019
ER
PT J
AU Park, H
Readio, N
Jin, G
Asfaha, S
Singh, A
Singh, A
Yang, XD
Patterson, KS
Trempus, C
Wang, TC
Morris, RJ
AF Park, Heuijoon
Readio, Nyssa
Jin, Guang
Asfaha, Samuel
Singh, Anupama
Singh, Ashok
Yang, Xiangdong
Patterson, Kelly S.
Trempus, Carol
Wang, Timothy C.
Morris, Rebecca J.
TI Bone marrow-derived epithelial cells contribute to chronic skin
inflammation and skin tumor formation in the mouse
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Park, Heuijoon; Jin, Guang; Asfaha, Samuel; Yang, Xiangdong; Patterson, Kelly S.; Wang, Timothy C.] Columbia Univ, New York, NY USA.
[Readio, Nyssa; Singh, Anupama; Singh, Ashok; Morris, Rebecca J.] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA.
[Trempus, Carol] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5202
DI 10.1158/1538-7445.AM2012-5202
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505065
ER
PT J
AU Park, SR
Kinders, RJ
Khin, S
Hollingshead, M
Parchment, RE
Tomaszewski, JE
Doroshow, JH
AF Park, Sook Ryun
Kinders, Robert J.
Khin, Sonny
Hollingshead, Melinda
Parchment, Ralph E.
Tomaszewski, Joseph E.
Doroshow, James H.
TI Validation and fitness testing of a quantitative immunoassay for HIF1
alpha in biopsy specimens
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Park, Sook Ryun; Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
[Kinders, Robert J.; Khin, Sonny; Parchment, Ralph E.] NCI Frederick, Lab Human Toxicol & Pharmacol, SAIC Frederick Inc, Frederick, MD USA.
[Hollingshead, Melinda] NCI Frederick, Biol Testing Branch, Dev Therapeut Program, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3616
DI 10.1158/1538-7445.AM2012-3616
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600383
ER
PT J
AU Peng, XJ
Yuan, L
Fatouma, A
Mehta, R
Kopelovich, L
McCormick, DL
AF Peng, Xinjian
Yuan, Liang
Fatouma, Alimirah
Mehta, Rajendra
Kopelovich, Levy
McCormick, David L.
TI Synergistic antiproliferative activity of combined administration of
atorvastatin and zoledronic acid in LNCaP and PC3 prostate cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Peng, Xinjian; Yuan, Liang; Fatouma, Alimirah; Mehta, Rajendra; McCormick, David L.] IIT, Res Inst, Chicago, IL 60616 USA.
[Kopelovich, Levy] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 613
DI 10.1158/1538-7445.AM2012-613
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503307
ER
PT J
AU Permuth-Wey, J
Lin, HY
Tsai, YY
Chen, ZH
Chen, YA
Barnholtz-Sloan, J
Birrer, MJ
Chanock, S
Cramer, DW
Cunningham, JM
Fenstermacher, D
Fridley, B
Garcia-Closas, M
Gayther, SA
Gentry-Maharaj, A
Gonzalez-Bosquet, J
Iversen, E
Jim, H
McLaughlin, J
Menon, U
Monteiro, A
Narod, SA
Phelan, CM
Ramus, S
Risch, H
Song, H
Sutphen, R
Terry, KL
Tyrer, J
Vierkant, RA
Wentzensen, N
Lancaster, JM
Cheng, JQ
Berchuk, A
Pharoah, PDP
Schildkraut, JM
Goode, EL
Sellers, TA
AF Permuth-Wey, Jennifer
Lin, Hui-Yi
Tsai, Ya-Yu
Chen, Zhihua
Chen, Y. Ann
Barnholtz-Sloan, Jill
Birrer, Micheal J.
Chanock, Stephen
Cramer, Daniel W.
Cunningham, Julie M.
Fenstermacher, David
Fridley, Brooke
Garcia-Closas, Montserrat
Gayther, Simon A.
Gentry-Maharaj, Alexandra
Gonzalez-Bosquet, Jesus
Iversen, Edwin
Jim, Heather
McLaughlin, John
Menon, Usha
Monteiro, Alvaro
Narod, Steven A.
Phelan, Catherine M.
Ramus, Susan
Risch, Harvey
Song, Honglin
Sutphen, Rebecca
Terry, Kathryn L.
Tyrer, Jonathan
Vierkant, Robert A.
Wentzensen, Nicolas
Lancaster, Johnathan M.
Cheng, Jin Q.
Berchuk, Andrew
Pharoah, Paul D. P.
Schildkraut, Joellen M.
Goode, Ellen L.
Sellers, Thomas A.
TI MicroRNA binding site polymorphisms influence ovarian cancer risk in the
collaborative oncological gene-environment study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Permuth-Wey, Jennifer; Lin, Hui-Yi; Tsai, Ya-Yu; Chen, Zhihua; Chen, Y. Ann; Fenstermacher, David; Gonzalez-Bosquet, Jesus; Jim, Heather; Monteiro, Alvaro; Phelan, Catherine M.; Lancaster, Johnathan M.; Cheng, Jin Q.; Sellers, Thomas A.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
[Barnholtz-Sloan, Jill] Case Comprehens Canc Ctr, Cleveland, OH USA.
[Birrer, Micheal J.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Chanock, Stephen; Wentzensen, Nicolas] NIH, Rockville, MD USA.
[Cramer, Daniel W.; Terry, Kathryn L.] Brigham Womens Hosp, Boston, MA USA.
[Cunningham, Julie M.; Fridley, Brooke; Vierkant, Robert A.; Goode, Ellen L.] Mayo Clin, Coll Med, Rochester, MN USA.
[Garcia-Closas, Montserrat] Inst Canc Res, London SW3 6JB, England.
[Garcia-Closas, Montserrat] Breakthrough Breast Canc Res Ctr, London, England.
[Gayther, Simon A.; Ramus, Susan] Univ So Calif, Los Angeles, CA USA.
[Gentry-Maharaj, Alexandra; Menon, Usha] UCL, EGA Inst Womens Hlth, London, England.
[Iversen, Edwin] Duke Univ, Dept Stat Sci, Durham, NC USA.
[McLaughlin, John] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Narod, Steven A.] Ctr Res Womens Hlth, Toronto, ON, Canada.
[Risch, Harvey] Yale Univ, Sch Med, New Haven, CT USA.
[Song, Honglin; Tyrer, Jonathan; Pharoah, Paul D. P.] Univ Cambridge, Cambridge, England.
[Sutphen, Rebecca] Univ S Florida, Tampa, FL USA.
[Berchuk, Andrew; Schildkraut, Joellen M.] Duke Univ, Med Ctr, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2927
DI 10.1158/1538-7445.AM2012-2927
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602478
ER
PT J
AU Pommier, YG
Murai, J
Takeda, S
AF Pommier, Yves G.
Murai, Junko
Takeda, Shunichi
TI Stabilization of PARP-DNA complexes plays a critical role for the
cytotoxic effects of the PARP inhibitors, veliparib and oliparib
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Pommier, Yves G.; Murai, Junko] NCI, CCR, Bethesda, MD 20892 USA.
[Takeda, Shunichi] Kyoto Med Univ, Kyoto, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4689
DI 10.1158/1538-7445.AM2012-4689
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603086
ER
PT J
AU Poplini, EA
August, DA
Ben-Menachem, T
Michael, H
Artymyshyn, R
Gulley, JL
Schlom, J
DiPaola, RS
Lattime, EC
AF Poplini, Elizabeth A.
August, David A.
Ben-Menachem, Tamir
Michael, Hazar
Artymyshyn, Renee
Gulley, James L.
Schlom, Jeffrey
DiPaola, Robert S.
Lattime, Edmund C.
TI Phase I trial of EUS-guided intratumoral vaccination with recombinant
Panvac-F and systemic Panvac-V in patients with locally advanced
pancreatic cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Poplini, Elizabeth A.; August, David A.; Ben-Menachem, Tamir; Michael, Hazar; Artymyshyn, Renee; DiPaola, Robert S.; Lattime, Edmund C.] Canc Inst New Jersey, New Brunswick, NJ USA.
[Gulley, James L.; Schlom, Jeffrey] NCI, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016
OI Gulley, James/0000-0002-6569-2912
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5378
DI 10.1158/1538-7445.AM2012-5378
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500299
ER
PT J
AU Poulikakos, PI
Persaud, Y
Janakiraman, M
Kong, XJ
Ng, C
Moriceau, G
Shi, HB
Atefi, M
Titz, B
Gabay, MT
Salton, M
Dahlman, KB
Tadi, M
Wargo, JA
Flaherty, KT
Kelley, MC
Misteli, T
Chapman, PB
Sosman, JA
Graeber, TG
Ribas, A
Lo, RS
Rosen, N
Solit, DB
AF Poulikakos, Poulikos I.
Persaud, Yogindra
Janakiraman, Manickam
Kong, Xiangju
Ng, Charles
Moriceau, Gatien
Shi, Hubing
Atefi, Mohammad
Titz, Bjoern
Gabay, May Tal
Salton, Maayan
Dahlman, Kimberly B.
Tadi, Madhavi
Wargo, Jennifer A.
Flaherty, Keith T.
Kelley, Mark C.
Misteli, Tom
Chapman, Paul B.
Sosman, Jeffrey A.
Graeber, Thomas G.
Ribas, Antoni
Lo, Roger S.
Rosen, Neal
Solit, David B.
TI RAS-independent dimerization of BRAF(V600E) splicing variants promotes
resistance to RAF inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Poulikakos, Poulikos I.; Persaud, Yogindra; Janakiraman, Manickam; Gabay, May Tal; Tadi, Madhavi; Chapman, Paul B.; Rosen, Neal; Solit, David B.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Kong, Xiangju; Ng, Charles; Moriceau, Gatien; Shi, Hubing; Atefi, Mohammad; Titz, Bjoern; Graeber, Thomas G.; Ribas, Antoni; Lo, Roger S.] Univ Calif Los Angeles, Los Angeles, CA USA.
[Salton, Maayan; Misteli, Tom] NCI, NIH, Bethesda, MD 20892 USA.
[Dahlman, Kimberly B.; Kelley, Mark C.; Sosman, Jeffrey A.] Vanderbilt Ingram Canc Ctr, Nashville, TN USA.
[Wargo, Jennifer A.; Flaherty, Keith T.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-428
DI 10.1158/1538-7445.AM2012-LB-428
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501094
ER
PT J
AU Prabhu, VV
Hong, B
Allen, JE
Dicker, DT
Navaraj, A
Kopelovich, L
El-Deiry, WS
AF Prabhu, Varun Vijay
Hong, Bo
Allen, Joshua E.
Dicker, David T.
Navaraj, Arunasalam
Kopelovich, Levy
El-Deiry, Wafik S.
TI Anti-tumor effects of p53-pathway restoring compound Prodigiosin in
colorectal cancer involve effects on apoptotic signaling, angiogenesis
and cancer stem cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Prabhu, Varun Vijay; Hong, Bo; Allen, Joshua E.; Dicker, David T.; Navaraj, Arunasalam; El-Deiry, Wafik S.] Penn State Coll Med, Penn State Hershey Canc Inst, Hematol Oncol, Hershey, PA USA.
[Kopelovich, Levy] NCI, Div Canc Prevent, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1170
DI 10.1158/1538-7445.AM2012-1170
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503134
ER
PT J
AU Pressler, HM
Sissung, TM
Price, DK
Figg, WD
AF Pressler, Heather M.
Sissung, Tristan M.
Price, Douglas K.
Figg, William D.
TI Expression of an androgen transporter, organic anion transporting
polypeptide 163, impacts progression and treatment of prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Pressler, Heather M.; Sissung, Tristan M.; Price, Douglas K.; Figg, William D.] NCI, Bethesda, MD 20892 USA.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1848
DI 10.1158/1538-7445.AM2012-1848
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501287
ER
PT J
AU Price, DK
Reece, KM
Troutman, SM
Pressler, HM
Pisle, ST
Figg, WD
AF Price, Douglas K.
Reece, Kelie M.
Troutman, Sarah M.
Pressler, Heather M.
Pisle, Stephen T.
Figg, William D.
TI Molecular interaction of HIF-1 alpha and the androgen receptor in
prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Price, Douglas K.; Reece, Kelie M.; Troutman, Sarah M.; Pressler, Heather M.; Figg, William D.] NCI, Bethesda, MD 20892 USA.
[Pisle, Stephen T.] NCI, SAIC Frederick, Frederick, MD 21701 USA.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2206
DI 10.1158/1538-7445.AM2012-2206
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606237
ER
PT J
AU Prickett, TD
Wei, XM
Cardenas-Navia, I
Teer, J
Lin, JC
Walia, V
Gartner, J
Jiang, J
Cherukuri, P
Molinolo, A
Davies, MA
Stamke-Hale, K
Margulies, EH
Rosenberg, SA
Samuels, Y
AF Prickett, Todd D.
Wei, Xiaomu
Cardenas-Navia, Isabel
Teer, Jamie
Lin, Jimmy C.
Walia, Vijay
Gartner, Jared
Jiang, Jiji
Cherukuri, Praveen
Molinolo, Alfredo
Davies, Michael A.
Stamke-Hale, Katherine
Margulies, Elliott H.
Rosenberg, Steven A.
Samuels, Yardena
TI Exon capture analysis of G-protein coupled receptors reveals activating
mutations in GRM3 in melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Prickett, Todd D.; Wei, Xiaomu; Cardenas-Navia, Isabel; Teer, Jamie; Walia, Vijay; Gartner, Jared; Jiang, Jiji; Cherukuri, Praveen; Margulies, Elliott H.; Samuels, Yardena] NHGRI, NIH, Bethesda, MD 20892 USA.
[Lin, Jimmy C.] Johns Hopkins Univ, Baltimore, MD USA.
[Molinolo, Alfredo] NIDCR, NIH, Bethesda, MD USA.
[Davies, Michael A.; Stamke-Hale, Katherine] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Rosenberg, Steven A.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4860
DI 10.1158/1538-7445.AM2012-4860
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501149
ER
PT J
AU Purdue, MP
Moore, L
Merino, MJ
Boffetta, P
Colt, JS
Schwartz, KL
Bencko, V
Davis, FG
Graubard, B
Janout, V
Ruterbusch, JJ
Beebe-Dimmer, J
Cote, M
Shuch, B
Mates, D
Hofmann, JN
Foretova, L
Rothman, N
Szeszenia-Dabrowska, N
Matveev, V
Wacholder, S
Zaridze, D
Linehan, WM
Brennan, P
Chow, WH
AF Purdue, Mark P.
Moore, Lee
Merino, Maria J.
Boffetta, Paolo
Colt, Joanne S.
Schwartz, Kendra L.
Bencko, Vladimir
Davis, Faith G.
Graubard, Barry
Janout, Vladimir
Ruterbusch, Julie J.
Beebe-Dimmer, Jennifer
Cote, Michele
Shuch, Brian
Mates, Dana
Hofmann, Jonathon N.
Foretova, Lenka
Rothman, Nathaniel
Szeszenia-Dabrowska, Neonilia
Matveev, Vsevolod
Wacholder, Sholom
Zaridze, David
Linehan, W. Marston
Brennan, Paul
Chow, Wong-Ho
TI An investigation of risk factors for renal cell carcinoma by histologic
subtype in two case-control studies
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Purdue, Mark P.; Moore, Lee; Colt, Joanne S.; Graubard, Barry; Hofmann, Jonathon N.; Rothman, Nathaniel; Wacholder, Sholom; Chow, Wong-Ho] NCI, Rockville, MD USA.
[Merino, Maria J.; Shuch, Brian; Linehan, W. Marston] NCI, Bethesda, MD 20892 USA.
[Boffetta, Paolo] Mt Sinai Sch Med, New York, NY USA.
[Schwartz, Kendra L.; Ruterbusch, Julie J.; Beebe-Dimmer, Jennifer; Cote, Michele] Wayne State Univ, Detroit, MI USA.
[Bencko, Vladimir] Charles Univ Prague, Prague, Czech Republic.
[Davis, Faith G.] Univ Illinois, Chicago, IL USA.
[Janout, Vladimir] Palacky Univ, CR-77147 Olomouc, Czech Republic.
[Mates, Dana] Inst Publ Hlth, Bucharest, Romania.
[Foretova, Lenka] Masaryk Mem Canc Inst, Brno, Czech Republic.
[Szeszenia-Dabrowska, Neonilia] Inst Occupat Med, Lodz, Poland.
[Matveev, Vsevolod; Zaridze, David] Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia.
[Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5515
DI 10.1158/1538-7445.AM2012-5515
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602177
ER
PT J
AU Raggi, C
Marquardt, JU
Seo, D
Andersen, JB
Factor, VM
Thorgeirsson, SS
AF Raggi, Chiara
Marquardt, Jens U.
Seo, Daekwan
Andersen, Jesper B.
Factor, Valentina M.
Thorgeirsson, Snorri S.
TI Epigenetic reprogramming affects malignant properties of human liver
cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Raggi, Chiara; Marquardt, Jens U.; Seo, Daekwan; Andersen, Jesper B.; Factor, Valentina M.; Thorgeirsson, Snorri S.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4261
DI 10.1158/1538-7445.AM2012-4261
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505232
ER
PT J
AU Ramaswamy, B
Lustberg, MB
Wesolowski, R
Layman, RM
Mrozek, E
Olson, EM
Andreopoulou, E
Garcia-Villa, A
Chalmers, J
Cotrill, JA
Nutter, J
Ledin, J
Schaaf, LJ
Bajestani, S
Zhao, WQ
Geyer, S
Chen, A
Shapiro, CL
Villalona-Calero, MA
Knopp, M
Grever, MR
AF Ramaswamy, Bhuvaneswari
Lustberg, Maryam B.
Wesolowski, Robert
Layman, Rachel M.
Mrozek, Ewa
Olson, Erin M.
Andreopoulou, Eleni
Garcia-Villa, Alejandra
Chalmers, Jeff
Cotrill, Jeffrey A.
Nutter, Julie
Ledin, Jamie
Schaaf, Larry J.
Bajestani, Saeed
Zhao, Weiqiang
Geyer, Susan
Chen, Alice
Shapiro, Charles L.
Villalona-Calero, Miguel A.
Knopp, Michael
Grever, Michael R.
TI Phase I study of PARP inhibitor ABT-888 and carboplatin with novel
imaging in metastatic breast cancer (MBC) (NCI-8609)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ramaswamy, Bhuvaneswari; Lustberg, Maryam B.; Wesolowski, Robert; Layman, Rachel M.; Mrozek, Ewa; Olson, Erin M.; Nutter, Julie; Ledin, Jamie; Shapiro, Charles L.] Ohio State Univ, Stefanie Spielman Comprehens Breast Ctr, Columbus, OH 43210 USA.
[Andreopoulou, Eleni] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA.
[Garcia-Villa, Alejandra; Chalmers, Jeff; Cotrill, Jeffrey A.; Schaaf, Larry J.; Bajestani, Saeed; Zhao, Weiqiang; Geyer, Susan; Villalona-Calero, Miguel A.; Knopp, Michael; Grever, Michael R.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Chen, Alice] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5586
DI 10.1158/1538-7445.AM2012-5586
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601166
ER
PT J
AU Rand, KA
Conti, DV
Haiman, CA
Van Den Berg, DJ
Birmann, BM
De Roos, AJ
Severson, RK
Gebregziabher, M
Ailawadhi, S
Morbacher, A
Lieber, MR
Wang, SS
Bernstein, L
Edlund, CK
Rothman, N
Chanock, SJ
Kolonel, LN
Colditz, GA
Munshi, N
Anderson, KC
Cozen, W
AF Rand, Kristin A.
Conti, David V.
Haiman, Christopher A.
Van Den Berg, David J.
Birmann, Brenda M.
De Roos, Anneclaire J.
Severson, Richard K.
Gebregziabher, Mulugeta
Ailawadhi, Sikander
Morbacher, Ann
Lieber, Michael R.
Wang, Sophia S.
Bernstein, Leslie
Edlund, Christopher K.
Rothman, Nathaniel
Chanock, Stephen J.
Kolonel, Laurence N.
Colditz, Graham A.
Munshi, Nikhil
Anderson, Kenneth C.
Cozen, Wendy
TI Polymorphisms in DNA repair genes and risk of multiple myeloma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Rand, Kristin A.; Conti, David V.; Haiman, Christopher A.; Lieber, Michael R.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
[Van Den Berg, David J.; Cozen, Wendy] Univ So Calif, Dept Prevent Med, Ctr Comprehens Canc, Los Angeles, CA 90089 USA.
[Van Den Berg, David J.; Cozen, Wendy] Univ So Calif, Dept Pathol, Ctr Comprehens Canc, Los Angeles, CA 90089 USA.
[Birmann, Brenda M.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.
[Birmann, Brenda M.] Harvard Univ, Sch Med, Boston, MA USA.
[De Roos, Anneclaire J.] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 USA.
[Severson, Richard K.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
[Gebregziabher, Mulugeta] Med Univ S Carolina, Div Biostat & Epidemiol, Charleston, SC 29425 USA.
[Ailawadhi, Sikander; Morbacher, Ann] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Div Hematol,Dept Med, Los Angeles, CA 90033 USA.
[Wang, Sophia S.; Bernstein, Leslie] City Hope Natl Med Ctr, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA.
[Edlund, Christopher K.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Rothman, Nathaniel; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Kolonel, Laurence N.] Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA.
[Colditz, Graham A.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
[Colditz, Graham A.] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO USA.
[Colditz, Graham A.] Barnes Jewish Hosp, St Louis, MO 63110 USA.
[Munshi, Nikhil; Anderson, Kenneth C.] Dana Farber Canc Inst, Dept Med Oncol, Jeroma Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2634
DI 10.1158/1538-7445.AM2012-2634
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602262
ER
PT J
AU Ranuncolo, SM
Xiao, WM
Wright, G
Abu-Asab, M
Pittaluga, S
Jaffe, ES
Lewis, B
AF Ranuncolo, Stella M.
Xiao, Wenming
Wright, George
Abu-Asab, Mones
Pittaluga, Stefania
Jaffe, Elaine S.
Lewis, Brian
TI Hodgkin Lymphoma requires stabilized NIK and constitutive ReIB
expression for survival
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ranuncolo, Stella M.; Xiao, Wenming; Wright, George; Abu-Asab, Mones; Pittaluga, Stefania; Jaffe, Elaine S.; Lewis, Brian] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-281
DI 10.1158/1538-7445.AM2012-LB-281
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501267
ER
PT J
AU Reinhold, WC
Sunshine, M
Varma, S
Liu, HF
Weinstein, JN
Morris, J
Doroshow, J
Pommier, Y
AF Reinhold, William C.
Sunshine, Margot
Varma, Sudir
Liu, Hongfang
Weinstein, John N.
Morris, Joel
Doroshow, James
Pommier, Yves
TI Web-based access for whole genome analyses of gene expression, DNA copy
number, microRNA transcript levels, drug activity, and their pattern
comparisons for the NCI-60
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Reinhold, William C.; Sunshine, Margot; Varma, Sudir; Pommier, Yves] NCI, Bethesda, MD 20892 USA.
[Liu, Hongfang] Mayo Clin, Rochester, MN USA.
[Weinstein, John N.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Morris, Joel] Drug Synth & Chem Branch, Rockville, MD USA.
[Doroshow, James] NCI, Off Director, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2991
DI 10.1158/1538-7445.AM2012-2991
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604197
ER
PT J
AU Richardson, ED
Reece, KM
Campbell, TJ
Pressler, H
Pisle, ST
Figg, WD
AF Richardson, Emily D.
Reece, Kelie M.
Campbell, Tessa J.
Pressler, Heather
Pisle, Stephen T.
Figg, William D.
TI Select epidithiodiketopiperazine (ETP) compounds disrupt the HIF-1
alpha/p300 interaction and HIF-mediated transcription
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Richardson, Emily D.; Reece, Kelie M.; Campbell, Tessa J.; Pressler, Heather] NCI, Mol Pharmacol Sect, Med Oncol Branch, Bethesda, MD 20892 USA.
[Pisle, Stephen T.] NCI, Clin Pharmacol Program, SAIC Frederick, Frederick, MD 21701 USA.
[Figg, William D.] NCI, Clin Pharmacol Program, Med Oncol Branch, Bethesda, MD 20892 USA.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2331
DI 10.1158/1538-7445.AM2012-2331
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504281
ER
PT J
AU Rivers, RC
Mesri, M
Kinsinger, C
Boja, E
Hiltke, T
Rodriguez, H
AF Rivers, Robert C.
Mesri, Mehdi
Kinsinger, Chris
Boja, Emily
Hiltke, Tara
Rodriguez, Henry
TI NCI's Clinical Proteomic Tumor Analysis Consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Rivers, Robert C.; Mesri, Mehdi; Kinsinger, Chris; Boja, Emily; Hiltke, Tara; Rodriguez, Henry] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1282
DI 10.1158/1538-7445.AM2012-1282
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502385
ER
PT J
AU Roberts, NJ
Jiao, YC
Yu, J
Kopelovich, L
Petersen, GM
Bondy, M
Gallinger, S
Schwartz, AG
Syngai, S
Cote, ML
Axilbund, J
Schulick, R
Ali, SZ
Eshleman, JR
Velculescu, V
Goggins, M
Vogelstein, B
Papadopoulous, N
Hruban, RH
Kinzler, KW
Klein, AP
AF Roberts, Nicholas J.
Jiao, Yuchen
Yu, Jun
Kopelovich, Levy
Petersen, Gloria M.
Bondy, Melissa
Gallinger, Steven
Schwartz, Ann G.
Syngai, Sapna
Cote, Michele L.
Axilbund, Jennifer
Schulick, Richard
Ali, Syed Z.
Eshleman, James R.
Velculescu, Victor
Goggins, Michael
Vogelstein, Bert
Papadopoulous, Nikolas
Hruban, Ralph H.
Kinzler, Kenneth W.
Klein, Alison P.
TI Genome-wide sequencing identifies ATM as a pancreatic cancer
susceptibility gene
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Roberts, Nicholas J.; Jiao, Yuchen; Yu, Jun; Axilbund, Jennifer; Schulick, Richard; Ali, Syed Z.; Eshleman, James R.; Velculescu, Victor; Goggins, Michael; Vogelstein, Bert; Papadopoulous, Nikolas; Hruban, Ralph H.; Kinzler, Kenneth W.; Klein, Alison P.] Johns Hopkins Univ, Baltimore, MD USA.
[Kopelovich, Levy] NCI, Bethesda, MD 20892 USA.
[Petersen, Gloria M.] Mayo Clin, Rochester, MN USA.
[Bondy, Melissa] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Gallinger, Steven] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Schwartz, Ann G.; Cote, Michele L.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA.
[Syngai, Sapna] Dana Farber Canc Inst, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2628
DI 10.1158/1538-7445.AM2012-2628
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602255
ER
PT J
AU Robey, RW
Luchenko, VL
Bahr, J
Chakraborty, AR
Zimmer, AS
Piekarz, RL
Bates, SE
AF Robey, Robert W.
Luchenko, Victoria L.
Bahr, Julian
Chakraborty, Arup R.
Zimmer, Alexandra S.
Piekarz, Richard L.
Bates, Susan E.
TI Combined mitogen-activated protein kinase pathway inhibition with
short-term romidepsin treatment induces proapoptotic Bim and cell death
in BRAF mutant cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Robey, Robert W.; Luchenko, Victoria L.; Bahr, Julian; Chakraborty, Arup R.; Piekarz, Richard L.; Bates, Susan E.] NCI, CCR, Bethesda, MD 20892 USA.
[Zimmer, Alexandra S.] Washington Hosp Ctr, Washington, DC 20010 USA.
RI Zimmer, Alexandra/K-6824-2016
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4709
DI 10.1158/1538-7445.AM2012-4709
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603339
ER
PT J
AU Rodina, A
Moulick, K
Ahn, J
Zong, HL
Cerchietti, L
DaGama, EG
Caldas-Lopes, E
Beebe, K
Perna, F
Hatzi, K
Vu, L
Zhao, XY
Zatorska, D
Taldone, T
Smith-Jones, P
Alpaugh, M
Gross, S
Pillarsetty, N
Ku, T
Lewis, J
Larson, S
Levine, R
Erdjument-Bromage, H
Guzman, M
Nimer, S
Melnick, A
Neckers, L
Chiosis, G
AF Rodina, Anna
Moulick, Kamalika
Ahn, James
Zong, Hongliang
Cerchietti, Leandro
DaGama, Erica Gomes
Caldas-Lopes, Eloisi
Beebe, Kristin
Perna, Fabiana
Hatzi, Katerina
Vu, Ly
Zhao, Xinyang
Zatorska, Danuta
Taldone, Tony
Smith-Jones, Peter
Alpaugh, Mary
Gross, Steven
Pillarsetty, Nagavarakishore
Ku, Thomas
Lewis, Jason
Larson, Steven
Levine, Ross
Erdjument-Bromage, Hediye
Guzman, Monica
Nimer, Stephen
Melnick, Ari
Neckers, Len
Chiosis, Gabriela
TI Biochemical evidence towards the existence of an oncogenic Hsp90 complex
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Rodina, Anna; Moulick, Kamalika; Ahn, James; DaGama, Erica Gomes; Caldas-Lopes, Eloisi; Perna, Fabiana; Vu, Ly; Zhao, Xinyang; Zatorska, Danuta; Taldone, Tony; Smith-Jones, Peter; Alpaugh, Mary; Pillarsetty, Nagavarakishore; Ku, Thomas; Lewis, Jason; Larson, Steven; Levine, Ross; Erdjument-Bromage, Hediye; Nimer, Stephen; Chiosis, Gabriela] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Zong, Hongliang; Cerchietti, Leandro; Hatzi, Katerina; Gross, Steven; Guzman, Monica; Melnick, Ari] Weill Cornell Med Coll, New York, NY USA.
[Beebe, Kristin; Neckers, Len] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3029
DI 10.1158/1538-7445.AM2012-3029
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604239
ER
PT J
AU Ruczinski, I
Jorgensen, T
Shugart, YY
Berthier-Schaad, Y
Kessing, B
Hoffman-Bolton, J
Helzlsouer, K
Kao, WHL
Wheless, L
Francis, L
Alani, R
Strickland, P
Smith, M
Alberg, AJ
AF Ruczinski, Ingo
Jorgensen, Timothy
Shugart, Yin Yao
Berthier-Schaad, Yvette
Kessing, Bailey
Hoffman-Bolton, Judithh
Helzlsouer, Kathy
Kao, W. H. Linda
Wheless, Lee
Francis, Lesley
Alani, Rhoda
Strickland, Paul
Smith, Michael
Alberg, Anthony J.
TI Nonmelanoma skin cancer as a marker of a cancer-prone phenotype:
Potential role of DNA repair gene variants
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ruczinski, Ingo; Berthier-Schaad, Yvette; Hoffman-Bolton, Judithh; Kao, W. H. Linda] Johns Hopkins Univ, Baltimore, MD USA.
[Jorgensen, Timothy] Georgetown Univ, Washington, DC USA.
[Shugart, Yin Yao] NIMH, Rockville, MD 20857 USA.
[Kessing, Bailey] NCI, Frederick, MD 21701 USA.
[Helzlsouer, Kathy] Mercy Med Ctr, Baltimore, MD USA.
[Wheless, Lee; Francis, Lesley; Alberg, Anthony J.] Med Univ S Carolina, Charleston, SC 29425 USA.
[Alani, Rhoda] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Smith, Michael] SAIC Frederick, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2636
DI 10.1158/1538-7445.AM2012-2636
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602264
ER
PT J
AU Russell, EA
Gembarska, A
Marine, JC
Bernal, F
AF Russell, Elisabeth A.
Gembarska, Agnieszka
Marine, Jean-Christophe
Bernal, Federico
TI Inhibition of the p53-HDMX interaction sensitizes melanoma to
chemotherapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Russell, Elisabeth A.; Bernal, Federico] NCI, Bethesda, MD 20892 USA.
[Gembarska, Agnieszka; Marine, Jean-Christophe] KULeuven, Leuven, Belgium.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4730
DI 10.1158/1538-7445.AM2012-4730
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604028
ER
PT J
AU Saleh, AD
Si, H
Lu, H
Yang, XPY
Chen, Z
Van Waes, C
Coupar, J
AF Saleh, Anthony D.
Si, Han
Lu, Hai
Yang, Xinping Yang
Chen, Zhong
Van Waes, Carter
Coupar, Jamie
TI Transcriptome sequencing identifies oncogenic microRNA signatures that
interact with NF-kappaB, TP53 and Notch signaling in head and neck
squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Saleh, Anthony D.; Si, Han; Lu, Hai; Yang, Xinping Yang; Chen, Zhong; Van Waes, Carter; Coupar, Jamie] NIDCD, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3177
DI 10.1158/1538-7445.AM2012-3177
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503132
ER
PT J
AU Saloustros, E
Mertz, E
Nesterova, M
Keil, M
Horvath, A
Nadella, K
Holmbeck, K
Liu, SS
Mandas, V
Shikha, K
Leikin, S
Robey, P
Stratakis, CA
AF Saloustros, Emmanouil
Mertz, Edward
Nesterova, Maria
Keil, Meg
Horvath, Anelia
Nadella, Kiran
Holmbeck, Kenn
Liu, Sisi
Mandas, Vince
Shikha, Kapil
Leikin, Sergey
Robey, Pamela
Stratakis, Constantine A.
TI COX-2 inhibition reduces bone tumor growth in animal models:A role for
celecoxib treatment in cAMP/protein kinase A-induced tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Saloustros, Emmanouil; Nesterova, Maria; Keil, Meg; Horvath, Anelia; Nadella, Kiran; Liu, Sisi; Mandas, Vince; Shikha, Kapil; Stratakis, Constantine A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, NIH, Bethesda, MD USA.
[Mertz, Edward; Leikin, Sergey] NICHHD, Sect Phys Biochem, Off Sci Director, NIH, Bethesda, MD 20892 USA.
[Holmbeck, Kenn; Robey, Pamela] Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 954
DI 10.1158/1538-7445.AM2012-954
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602007
ER
PT J
AU Saloustros, E
Tsang, K
Mertz, E
Starost, M
Nesterova, M
Nadella, K
Horvath, A
Sierra, L
Liu, S
Cole, ME
Holmbeck, K
Leikin, S
Robey, P
Stratakis, C
AF Saloustros, Emmanouil
Tsang, Kitman
Mertz, Edward
Starost, Matthew
Nesterova, Maria
Nadella, Kiran
Horvath, Anelia
Sierra, Lucy
Liu, Sisi
Cole, Mary E.
Holmbeck, Kenn
Leikin, Sergey
Robey, Pamela
Stratakis, Constantine
TI A mouse model of double heterozygosity for protein kinase A regulatory
subunits promotes osteoblastic differentiation of cAMP-induced bone
tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Saloustros, Emmanouil; Tsang, Kitman; Nesterova, Maria; Nadella, Kiran; Horvath, Anelia; Sierra, Lucy; Liu, Sisi; Stratakis, Constantine] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, Bethesda, MD USA.
[Mertz, Edward; Leikin, Sergey] NICHHD, Sect Phys Biochem, Off Sci Director, NIH, Bethesda, MD 20892 USA.
[Starost, Matthew] NIH, Off Res Serv, Div Vet Resources, Bethesda, MD 20892 USA.
[Cole, Mary E.] NICHHD, Sect Phys Biochem, Off Sci Director, NIH, Bethesda, MD 20892 USA.
[Holmbeck, Kenn; Robey, Pamela] Natl Inst Dent Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1360
DI 10.1158/1538-7445.AM2012-1360
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504409
ER
PT J
AU Sato, N
Aras, O
Choyke, P
AF Sato, Noriko
Aras, Omer
Choyke, Peter
TI Near-infrared optical imaging visualizes tumor cell death induced by
adoptive transferred T cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Sato, Noriko; Aras, Omer; Choyke, Peter] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4291
DI 10.1158/1538-7445.AM2012-4291
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505428
ER
PT J
AU Schwentner, R
Bilke, S
Kauer, M
Jug, G
Walker, RL
Meltzer, PS
Kovar, H
AF Schwentner, Raphaela
Bilke, Sven
Kauer, Max
Jug, Gunhild
Walker, Robert L.
Meltzer, Paul S.
Kovar, Heinrich
TI A functional ETS/E2F module in cancers expressing ETS fusion genes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Schwentner, Raphaela; Kauer, Max; Jug, Gunhild; Kovar, Heinrich] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria.
[Bilke, Sven; Walker, Robert L.; Meltzer, Paul S.] NCI, Genet Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2198
DI 10.1158/1538-7445.AM2012-2198
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606229
ER
PT J
AU Segars, LE
Mendoza, A
Helman, LJ
Grohar, PJ
AF Segars, Laura E.
Mendoza, Arnulfo
Helman, Lee J.
Grohar, Patrick J.
TI ET-743 interferes with EWS-FLI1 driven WRN expression in Ewing sarcoma
cells and sensitizes to topoisomerase I inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Segars, Laura E.; Mendoza, Arnulfo; Helman, Lee J.] NCI, Bethesda, MD 20892 USA.
[Grohar, Patrick J.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2497
DI 10.1158/1538-7445.AM2011-2497
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501493
ER
PT J
AU Setiawan, VW
Yang, HP
Pike, MC
McCann, S
Yu, H
Xiang, YB
Wolle, A
Wentzensen, N
Weiss, NS
Webb, PM
van den Brande, PA
van de Vijver, K
Thompson, PJ
Strom, BL
Spurdle, AB
Shu, XO
Schairer, C
Sacerdote, C
Rohan, TE
Robien, K
Risch, H
Ricceri, F
Rebbeck, TR
Rastogi, R
Prescott, J
Polidoro, S
Park, Y
Olson, SH
Moysich, KB
Miller, AB
McCullough, ML
Matsuno, RK
Magliocco, AM
Lurie, G
Lu, LG
Lissowska, J
Liang, XL
Lacey, JV
Kolonel, LN
Henderson, BE
Hankinson, SE
Hakansson, N
Goodman, MT
Gaudet, MM
Garcia-Closas, M
Friedenreich, C
Freudenheim, JL
Doherty, J
AF Setiawan, Veronica Wendy
Yang, Hannah P.
Pike, Malcolm C.
McCann, Susan
Yu, Herbert
Xiang, Yong-Bing
Wolle, Alicia
Wentzensen, Nicolas
Weiss, Noel S.
Webb, Penelope M.
van den Brande, Piet A.
van de Vijver, Koen
Thompson, Pamela J.
Strom, Brian L.
Spurdle, Amanda B.
Shu, Xiao-ou
Schairer, Catherine
Sacerdote, Carlotta
Rohan, Thomas E.
Robien, Kim
Risch, Harvey
Ricceri, Fulvio
Rebbeck, Timothy R.
Rastogi, Radhai
Prescott, Jennifer
Polidoro, Silvia
Park, Yikyung
Olson, Sara H.
Moysich, Kirsten B.
Miller, Anthony B.
McCullough, Marjorie L.
Matsuno, Rayna K.
Magliocco, Anthony M.
Lurie, Galina
Lu, Lingeng
Lissowska, Jolanta
Liang, Xiaolin
Lacey, James V.
Kolonel, Laurence N.
Henderson, Brian E.
Hankinson, Susan E.
Hakansson, Niclas
Goodman, Marc T.
Gaudet, Mia M.
Garcia-Closas, Montserrat
Friedenreich, Christine
Freudenheim, Jo L.
Doherty, Jennifer
CA Australian Natl Endometrial Canc
TI The association of body mass index with risk of endometrial cancer
subtypes: Pooled analysis in E2C2
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Setiawan, Veronica Wendy; Pike, Malcolm C.; Henderson, Brian E.] Univ So Calif, Los Angeles, CA USA.
[Yang, Hannah P.; Wentzensen, Nicolas; Schairer, Catherine; Park, Yikyung] NCI, Bethesda, MD 20892 USA.
[McCann, Susan; Moysich, Kirsten B.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
[Yu, Herbert; Risch, Harvey; Lu, Lingeng] Yale Univ, New Haven, CT USA.
[Xiang, Yong-Bing] Shanghai Canc Inst, Shanghai, Peoples R China.
[Wolle, Alicia; Hakansson, Niclas] Karolinska Inst, Stockholm, Sweden.
[Weiss, Noel S.] Univ Washington, Seattle, WA 98195 USA.
[Webb, Penelope M.; Spurdle, Amanda B.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
[van den Brande, Piet A.; van de Vijver, Koen] Maastricht Univ, NL-6200 MD Maastricht, Netherlands.
[Thompson, Pamela J.; Matsuno, Rayna K.; Lurie, Galina; Kolonel, Laurence N.; Goodman, Marc T.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
[Strom, Brian L.; Rebbeck, Timothy R.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
[Shu, Xiao-ou] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
[Sacerdote, Carlotta] CPO Piemonte, Turin, Italy.
[Rohan, Thomas E.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
[Robien, Kim] Univ Minnesota, Minneapolis, MN USA.
[Ricceri, Fulvio; Polidoro, Silvia] Human Genet Fdn HuGeF, Turin, Italy.
[Rastogi, Radhai; Olson, Sara H.; Liang, Xiaolin] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Prescott, Jennifer] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Prescott, Jennifer] Harvard Univ, Sch Med, Boston, MA USA.
[Miller, Anthony B.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
[McCullough, Marjorie L.; Gaudet, Mia M.] Amer Canc Soc, Atlanta, GA 30329 USA.
[Magliocco, Anthony M.] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA.
[Lissowska, Jolanta] M Sklowdowska Curie Mem Canc Ctr & Inst Oncol, Warsaw, Poland.
[Lacey, James V.] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA USA.
[Hankinson, Susan E.] Univ Massachusetts, Amherst, MA 01003 USA.
[Garcia-Closas, Montserrat] Inst Canc Res, Surrey, England.
[Friedenreich, Christine] Alberta Hlth Serv Canc Care, Calgary, AB, Canada.
[Freudenheim, Jo L.] Univ Buffalo, SUNY, Buffalo, NY USA.
[Doherty, Jennifer] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1029
DI 10.1158/1538-7445.AM2012-1029
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602400
ER
PT J
AU Severson, PL
Tokar, EJ
Vrba, L
Waalkes, MP
Futscher, BW
AF Severson, Paul L.
Tokar, Erik J.
Vrba, Lukas
Waalkes, Michael P.
Futscher, Bernard W.
TI Common targets of epigenetic dysfunction in distinct target tissues of
arsenic and cadmium induced malignant transformation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Severson, Paul L.; Futscher, Bernard W.] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA.
[Tokar, Erik J.; Waalkes, Michael P.] NIEHS, Natl Toxicol Program Lab, Res Triangle Pk, NC 27709 USA.
[Vrba, Lukas] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5448
DI 10.1158/1538-7445.AM2012-5448
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600195
ER
PT J
AU Shi, JX
Li, P
AF Shi, Jianxin
Li, Peng
TI A novel statistical method for detecting association of copy number
variations in genome-wide association studies of cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Shi, Jianxin; Li, Peng] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3969
DI 10.1158/1538-7445.AM2012-3969
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605071
ER
PT J
AU Shi, JX
Chatterjee, N
Rotunno, M
Wang, YF
Pesatori, AC
Consonni, D
Li, P
Broderick, P
Henrion, M
Eisen, T
Wang, ZM
Chen, W
Dong, Q
Albanes, D
Thun, M
Spitz, M
Bertazzi, PA
Caporaso, N
Chanock, S
Amos, C
Houlston, R
Landi, MT
AF Shi, Jianxin
Chatterjee, Nilanjan
Rotunno, Melissa
Wang, Yufei
Pesatori, Angela C.
Consonni, Dario
Li, Peng
Broderick, Peter
Henrion, Marc
Eisen, Timothy
Wang, Zhaoming
Chen, Wei
Dong, Qiong
Albanes, Demetrius
Thun, Michael
Spitz, Margaret
Bertazzi, Pier Alberto
Caporaso, Neil
Chanock, Stephen
Amos, Christopher
Houlston, Richard
Landi, Maria Teresa
TI Inherited variation at chromosome 12p13.33 including RAD52 influences
squamous cell lung carcinoma risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Shi, Jianxin; Chatterjee, Nilanjan; Rotunno, Melissa; Pesatori, Angela C.; Consonni, Dario; Li, Peng; Wang, Zhaoming; Albanes, Demetrius; Bertazzi, Pier Alberto; Caporaso, Neil; Chanock, Stephen; Landi, Maria Teresa] NCI, DCEG, Bethesda, MD 20892 USA.
[Wang, Yufei; Broderick, Peter; Henrion, Marc; Houlston, Richard] ICR, Sutton, Surrey, England.
[Eisen, Timothy] Univ Cambridge, Cambridge, England.
[Chen, Wei; Dong, Qiong; Spitz, Margaret; Amos, Christopher] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Thun, Michael] Amer Canc Soc, Atlanta, GA 30329 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2931
DI 10.1158/1538-7445.AM2012-2931
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603024
ER
PT J
AU Shukla, S
Shankavaram, U
Smart, D
AF Shukla, Sudhanshu
Shankavaram, Uma
Smart, DeeDee
TI Proteomic analysis of acute radiation response following whole brain
irradiation: Is Sirt2 a key player of radiation induced neurotoxicity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Shukla, Sudhanshu; Shankavaram, Uma; Smart, DeeDee] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4354
DI 10.1158/1538-7445.AM2012-4354
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502054
ER
PT J
AU Si, H
Lu, H
Yang, XP
Jang, MY
Burnett, J
Davis, S
Sun, HW
Xiao, WM
Wei, L
Meltzer, P
Van Waes, C
Chen, Z
AF Si, Han
Lu, Hai
Yang, Xinping
Jang, Minyoung
Burnett, Jeffery
Davis, Sean
Sun, Hong-wei
Xiao, Wenming
Wei, Lai
Meltzer, Paul
Van Waes, Carter
Chen, Zhong
TI TNF-alpha dynamically modulates genome-wide cross-regulation of cRel,
Delta Np63 and TAp73 promoter binding and gene expression in head and
neck cancer: TP53 and NF kappa B ChIP-Seq in HNSCC
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Si, Han; Lu, Hai; Yang, Xinping; Jang, Minyoung; Burnett, Jeffery; Van Waes, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
[Davis, Sean; Meltzer, Paul] NCI, NIH, Bethesda, MD 20892 USA.
[Sun, Hong-wei] NIAMS, NIH, Bethesda, MD USA.
[Xiao, Wenming] NIH, CIT, Bethesda, MD 20892 USA.
[Wei, Lai] NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4193
DI 10.1158/1538-7445.AM2012-4193
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502430
ER
PT J
AU Smith, M
Keir, S
Maris, J
Kolb, A
Reynolds, P
Kang, M
Carol, H
Lock, R
Gorlick, R
Kurmasheva, R
Billups, C
Houghton, P
AF Smith, Malcolm
Keir, Stephen
Maris, John
Kolb, Anders
Reynolds, Patrick
Kang, Min
Carol, Hernan
Lock, Richard
Gorlick, Richard
Kurmasheva, Raushan
Billups, Catherine
Houghton, Peter
TI Pediatric Preclinical Testing Program (PPTP) evaluation of volasertib
(BI 6727), a Polo-like kinase (PLK) inhibitor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Smith, Malcolm] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
[Keir, Stephen] Duke Univ, Med Ctr, Durham, NC USA.
[Maris, John] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Kolb, Anders] Alfred I DuPont Hosp Children, Wilmington, DE USA.
[Reynolds, Patrick; Kang, Min] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
[Carol, Hernan; Lock, Richard] Childrens Canc Inst Australia, Randwick, NSW, Australia.
[Gorlick, Richard] Montefiore Med Ctr, Bronx, NY 10467 USA.
[Kurmasheva, Raushan; Houghton, Peter] Nationwide Childrens Hosp, Columbus, OH USA.
[Billups, Catherine] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-317
DI 10.1158/1538-7445.AM2012-LB-317
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504220
ER
PT J
AU Solomon, D
Kim, T
Diaz-Martinez, L
Fair, J
Elkahloun, A
Harris, B
Toretsky, J
Rosenberg, S
Shukla, N
Ladanyi, M
Samuels, Y
James, CD
Yu, HT
Kim, JS
Waldman, T
AF Solomon, David
Kim, Taeyon
Diaz-Martinez, Laura
Fair, Joshlean
Elkahloun, Abdel
Harris, Brent
Toretsky, Jeffrey
Rosenberg, Steven
Shukla, Neerav
Ladanyi, Marc
Samuels, Yardena
James, C. David
Yu, Hongtao
Kim, Jung-Sik
Waldman, Todd
TI Mutational inactivation of STAG2 causes aneuploidy in human cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Solomon, David; Kim, Taeyon; Fair, Joshlean; Harris, Brent; Toretsky, Jeffrey; Kim, Jung-Sik; Waldman, Todd] Georgetown Univ, Sch Med, Washington, DC USA.
[Diaz-Martinez, Laura; Yu, Hongtao] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Elkahloun, Abdel; Samuels, Yardena] NHGRI, NIH, Bethesda, MD 20892 USA.
[Rosenberg, Steven] NCI, NIH, Bethesda, MD 20892 USA.
[Shukla, Neerav; Ladanyi, Marc] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[James, C. David] UCSF, San Francisco, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3114
DI 10.1158/1538-7445.AM2012-3114
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605202
ER
PT J
AU Spitzner, M
Roesler, B
Bielfeld, C
Gaedcke, J
Rave-Frank, M
Beissbarth, T
Ried, T
Ghadimi, BM
Grade, M
AF Spitzner, Melanie
Roesler, Birte
Bielfeld, Christian
Gaedcke, Jochen
Rave-Fraenk, Margret
Beissbarth, Tim
Ried, Thomas
Ghadimi, B. Michael
Grade, Marian
TI Stat3 is a potential molecular target for chemoradiosensitization of
colorectal cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Spitzner, Melanie; Roesler, Birte; Bielfeld, Christian; Gaedcke, Jochen; Rave-Fraenk, Margret; Beissbarth, Tim; Ghadimi, B. Michael; Grade, Marian] Univ Med Ctr Gottingen, Gottingen, Germany.
[Ried, Thomas] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3446
DI 10.1158/1538-7445.AM2012-3446
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502014
ER
PT J
AU Srivastava, AK
Hollingshead, MH
Weiner, J
Park, SR
Kinders, RJ
Kummar, S
Tomaszewski, J
Parchment, RE
Doroshow, JH
AF Srivastava, Apurva K.
Hollingshead, Melinda H.
Weiner, Jennifer
Park, Sook Ryun
Kinders, Robert J.
Kummar, Shivaani
Tomaszewski, Joseph
Parchment, Ralph E.
Doroshow, James H.
TI Preclinical assessment of MET modulation by a VEGFR inhibitor/MET
inhibitor combination that shows additive antitumor efficacy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Srivastava, Apurva K.; Weiner, Jennifer; Kinders, Robert J.; Parchment, Ralph E.] SAIC Frederick, Frederick, MD USA.
[Hollingshead, Melinda H.] NCI, Frederick, MD 21701 USA.
[Park, Sook Ryun; Kummar, Shivaani; Tomaszewski, Joseph; Doroshow, James H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3672
DI 10.1158/1538-7445.AM2012-3672
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601231
ER
PT J
AU Takata, Y
Shu, XO
Yang, G
Li, HL
Dai, Q
Gao, J
Cai, QY
Chow, WH
Gao, YT
Zheng, W
AF Takata, Yumie
Shu, Xiao Ou
Yang, Gong
Li, Honglan
Dai, Qi
Gao, Jing
Cai, Qiuyin
Chow, Wong-Ho
Gao, Yutang
Zheng, Wei
TI Association between dietary calcium intake and lung cancer risk in
female non-smokers: A report from the Shanghai Women's Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Takata, Yumie; Shu, Xiao Ou; Yang, Gong; Dai, Qi; Cai, Qiuyin; Zheng, Wei] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
[Li, Honglan; Gao, Jing; Gao, Yutang] Shanghai Canc Inst, Shanghai, Peoples R China.
[Chow, Wong-Ho] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 631
DI 10.1158/1538-7445.AM2012-631
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602086
ER
PT J
AU Tanaka, N
Jeong, JH
Gavin, PG
Pogue-Geile, KL
Paik, S
Costantino, JP
AF Tanaka, Noriko
Jeong, Jong-Hyeon
Gavin, Patrick G.
Pogue-Geile, Katherine L.
Paik, Soonmyung
Costantino, Joseph P.
TI Graphical method to predict drug response using genomic biomarkers with
nonlinear interaction effect
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Tanaka, Noriko; Jeong, Jong-Hyeon; Gavin, Patrick G.; Pogue-Geile, Katherine L.; Paik, Soonmyung; Costantino, Joseph P.] NSABP, Pittsburgh, PA USA.
[Tanaka, Noriko; Jeong, Jong-Hyeon; Costantino, Joseph P.] NSABP Biostat Ctr, Pittsburgh, PA USA.
[Tanaka, Noriko; Jeong, Jong-Hyeon; Costantino, Joseph P.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2711
DI 10.1158/1538-7445.AM2012-2711
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701601349
ER
PT J
AU Tang, W
Jones, TL
Pitt, J
Ambs, S
Caplen, NJ
Prokunina, L
AF Tang, Wei
Jones, Tamara L.
Pitt, Jason
Ambs, Stefan
Caplen, Natasha J.
Prokunina, Ludmila
TI From genome-wide association studies (GWAS) to functional genomics of
prostate cancer: exploring the role of candidate transcripts through
RNAi-based analysis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Tang, Wei; Prokunina, Ludmila] NCI, DCEG, Gaithersburg, MD USA.
[Jones, Tamara L.; Caplen, Natasha J.] NCI, CCR, CGB, Bethesda, MD 20892 USA.
[Pitt, Jason] Univ Chicago, Chicago, IL 60637 USA.
[Ambs, Stefan] NCI, CCR, LHC, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 96
DI 10.1158/1538-7445.AM2012-96
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605371
ER
PT J
AU Tang, W
Fu, YP
Figueroa, JD
Malats, N
Garcia-Closas, M
Chatterjee, N
Kogevinas, M
Chanock, SJ
Silverman, DT
Rothman, N
Prokunina-Olsson, L
AF Tang, Wei
Fu, Yi-Ping
Figueroa, Jonine D.
Malats, Nuria
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Kogevinas, Manolis
Chanock, Stephen J.
Silverman, Debra T.
Rothman, Nathaniel
Prokunina-Olsson, Ludmila
TI Post-GWAS genetic and functional studies for bladder cancer: An uncommon
protective synonymous coding variant within the UGT1A6 gene explains the
GWAS signal and affects cellular detoxification
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Tang, Wei; Fu, Yi-Ping; Prokunina-Olsson, Ludmila] NCI, DCEG, Lab Translat Genom, Bethesda, MD 20892 USA.
[Figueroa, Jonine D.; Chatterjee, Nilanjan; Chanock, Stephen J.; Silverman, Debra T.; Rothman, Nathaniel] NCI, DCEG, Bethesda, MD 20892 USA.
[Malats, Nuria] Spanish Natl Canc Res Ctr, Madrid, Spain.
[Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England.
[Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
RI Kogevinas, Manolis/C-3918-2017
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1658
DI 10.1158/1538-7445.AM2012-1658
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602205
ER
PT J
AU Tao, MH
Marian, C
Shields, P
Postischman, N
Nie, J
Ambrosone, C
Edge, S
Krishnan, S
Vito, D
Trevisan, M
Freudenheim, J
AF Tao, Menghua
Marian, Catalin
Shields, Peter
Postischman, Nancy
Nie, Jing
Ambrosone, Christine
Edge, Stephen
Krishnan, Shiva
Vito, Dominica
Trevisan, Maurizio
Freudenheim, Jo
TI Early life exposures and promoter methylation in breast cancer: the
Western New York Exposures and Breast Cancer (WEB) Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Tao, Menghua] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA.
[Marian, Catalin; Shields, Peter; Krishnan, Shiva] Ohio State Univ, Ctr Canc, Columbus, OH 43210 USA.
[Postischman, Nancy] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Nie, Jing; Vito, Dominica; Trevisan, Maurizio; Freudenheim, Jo] Univ Buffalo, Dep Social & Prevent Med, Buffalo, NY USA.
[Ambrosone, Christine] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA.
[Edge, Stephen] Roswell Pk Canc Inst, Dept Surg, Buffalo, NY 14263 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4483
DI 10.1158/1538-7445.AM2012-4483
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602012
ER
PT J
AU Thompson, DN
Barrett, RA
Deonarine, A
Williams, CD
White-Coleman, D
Thomas, A
Horton, S
Cross, AJ
Laiyemo, AO
AF Thompson, Dianne N.
Barrett, Richard A.
Deonarine, Anand
Williams, Carla D.
White-Coleman, Debra
Thomas, Alicia
Horton, Sara
Cross, Amanda J.
Laiyemo, Adeyinka O.
TI The effect of lung cancer screening awareness on smoking behavior among
US adults
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Thompson, Dianne N.; Barrett, Richard A.] Howard Univ, Coll Med, Washington, DC USA.
[Deonarine, Anand; White-Coleman, Debra; Thomas, Alicia; Horton, Sara; Laiyemo, Adeyinka O.] Howard Univ, Coll Med, Dept Med, Washington, DC USA.
[Williams, Carla D.] Howard Univ, Ctr Canc, Washington, DC 20059 USA.
[Cross, Amanda J.] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 654
DI 10.1158/1538-7445.AM2012-654
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602109
ER
PT J
AU Trabert, B
Erickson, RL
Graubard, BI
Stanczyk, FZ
McGlynn, KA
AF Trabert, Britton
Erickson, Ralph L.
Graubard, Barry I.
Stanczyk, Frank Z.
McGlynn, Katherine A.
TI Pre-diagnostic gonadotropin levels and development of testicular germ
cell tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Trabert, Britton; Graubard, Barry I.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Stanczyk, Frank Z.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4470
DI 10.1158/1538-7445.AM2012-4470
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603368
ER
PT J
AU Trucco, M
Wilky, BA
Awad, O
Shah, P
Gul, N
Xia, MH
Huang, RL
Loeb, DM
AF Trucco, Matteo
Wilky, Breelyn A.
Awad, Ola
Shah, Preeti
Gul, Naheed
Xia, Menghang
Huang, Ruili
Loeb, David M.
TI Establishment of a chordoma xenograft and in vivo testing of compounds
identified by high-throughput screening
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Trucco, Matteo; Wilky, Breelyn A.; Shah, Preeti; Gul, Naheed; Loeb, David M.] Johns Hopkins Univ, Baltimore, MD USA.
[Awad, Ola] Suez Canal Univ, Ismailia, Egypt.
[Xia, Menghang; Huang, Ruili] NIH, Chem Genom Ctr, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-110
DI 10.1158/1538-7445.AM2012-LB-110
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504187
ER
PT J
AU Tucker, JA
Huen, NY
Pang, ALY
Lee, TL
Vergati, M
Intrivici, C
Cereda, V
Jochems, C
Chan, WY
Rennert, O
Gulley, JL
Schlom, J
Tsang, KY
AF Tucker, Jo A.
Huen, Ngar-Yee
Pang, Alan L. Y.
Lee, Tin-Lap
Vergati, Matteo
Intrivici, Chiara
Cereda, Vittore
Jochems, Caroline
Chan, Wai-Yee
Rennert, Owen
Gulley, James L.
Schlom, Jeffrey
Tsang, Kwong-Yok
TI Up-regulation of proliferative and migratory genes in regulatory T cells
from patients with metastatic castration-resistant prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Tucker, Jo A.; Huen, Ngar-Yee; Vergati, Matteo; Intrivici, Chiara; Cereda, Vittore; Jochems, Caroline; Gulley, James L.; Schlom, Jeffrey; Tsang, Kwong-Yok] NCI, Bethesda, MD 20892 USA.
[Pang, Alan L. Y.; Lee, Tin-Lap; Chan, Wai-Yee; Rennert, Owen] NICHHD, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016
OI Gulley, James/0000-0002-6569-2912
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5404
DI 10.1158/1538-7445.AM2012-5404
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500476
ER
PT J
AU Valdora, F
Freier, F
Seyler, C
Brady, N
Kranz, D
Hielscher, T
Bender, S
Northcott, P
Kool, M
Jones, D
Witt, H
Ryzhova, M
Pleier, S
Coco, S
Tonini, GP
Benner, A
von Deimling, A
Scheurlen, W
Boutros, M
Taylor, M
Katus, H
Kulozik, A
Lichter, P
Korshunov, A
Zitron, E
Pfister, S
Remke, M
AF Valdora, Francesca
Freier, Florian
Seyler, Claudia
Brady, Nathan
Kranz, Dominique
Hielscher, Thomas
Bender, Sebastian
Northcott, Paul
Kool, Marcel
Jones, David
Witt, Hendrik
Ryzhova, Marina
Pleier, Sabrina
Coco, Simona
Tonini, Gian Paolo
Benner, Axel
von Deimling, Andreas
Scheurlen, Wolfram
Boutros, Michael
Taylor, Michael
Katus, Hugo
Kulozik, Andreas
Lichter, Peter
Korshunov, Andrey
Zitron, Edgar
Pfister, Stefan
Remke, Marc
TI KCNJ2 comprises a marker of poor prognosis and a therapeutic target in
non-WNT/non-SHH medulloblastoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Valdora, Francesca; Freier, Florian; Brady, Nathan; Kranz, Dominique; Hielscher, Thomas; Bender, Sebastian; Kool, Marcel; Jones, David; Witt, Hendrik; Pleier, Sabrina; Benner, Axel; Boutros, Michael; Lichter, Peter; Pfister, Stefan; Remke, Marc] German Canc Res Ctr, Heidelberg, Germany.
[Seyler, Claudia; von Deimling, Andreas; Katus, Hugo; Kulozik, Andreas; Korshunov, Andrey; Zitron, Edgar] Heidelberg Univ, Heidelberg, Germany.
[Northcott, Paul; Taylor, Michael] Univ Toronto, Toronto, ON, Canada.
[Ryzhova, Marina] NN Burdenko Inst Neurosurg, Moscow, Russia.
[Coco, Simona; Tonini, Gian Paolo] Natl Canc Inst, Genoa, Italy.
[Scheurlen, Wolfram] Nurnberg Childrens Hosp, Nurnberg, Germany.
RI Coco, Simona/J-6051-2016; Katus, Hugo/P-1712-2016
OI Coco, Simona/0000-0002-5296-4325;
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1424
DI 10.1158/1538-7445.AM2012-1424
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501445
ER
PT J
AU Valle, BL
D'Souza, T
Becker, KG
Wood, WH
Wersto, RP
Morin, PJ
AF Valle, Blanca L.
D'Souza, Theresa
Becker, Kevin G.
Wood, William H.
Wersto, Robert P.
Morin, Patrice J.
TI The anti-proliferative effects of non-steroidal anti-inflammatory drugs
(NSAIDs) diclofenac and indomethacin in ovarian cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Valle, Blanca L.; D'Souza, Theresa; Becker, Kevin G.; Wood, William H.; Wersto, Robert P.; Morin, Patrice J.] NIA, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4673
DI 10.1158/1538-7445.AM2012-4673
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603005
ER
PT J
AU Vathipadiekal, V
Ozbun, L
Lee, JW
Vivas-Mejia, P
Lopez-Berestein, G
Sood, AK
Mok, SC
Birrer, MJ
AF Vathipadiekal, Vinod
Ozbun, Laurent
Lee, Jeong-Won
Vivas-Mejia, Pablo
Lopez-Berestein, Gabriel
Sood, Anil K.
Mok, Samuel C.
Birrer, Michael J.
TI Gene expression profile of chemoresponse of microdissected papillary
serous tumors of the ovary identifies POLH and REV3L as potential
therapeutic targets
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Vathipadiekal, Vinod; Birrer, Michael J.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Ozbun, Laurent] NCI, Bethesda, MD 20892 USA.
[Lee, Jeong-Won; Vivas-Mejia, Pablo; Lopez-Berestein, Gabriel; Sood, Anil K.; Mok, Samuel C.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5057
DI 10.1158/1538-7445.AM2012-5057
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606259
ER
PT J
AU Vazquez-Ortiz, G
Chisholm, CL
Huang, RL
Li, CL
Xu, XL
Rui-Hong, W
Deng, CX
AF Vazquez-Ortiz, Guelaguetza
Chisholm, Cristine L.
Huang, Ruili
Li, Culling
Xu, Xiaoling
Rui-Hong, Wang
Deng, Chuxia
TI Identification of synergistic effect of autophagy inhibitors and
resveratrol on BRCA1 mutant cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Vazquez-Ortiz, Guelaguetza; Chisholm, Cristine L.; Li, Culling; Xu, Xiaoling; Rui-Hong, Wang; Deng, Chuxia] GDDB NIDDK NIH, Bethesda, MD USA.
[Huang, Ruili] NHGRI, Genom Ctr, NIH, Bethesda, MD 20892 USA.
RI deng, chuxia/N-6713-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2744
DI 10.1158/1538-7445.AM2012-2744
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603166
ER
PT J
AU Vogtmann, E
Li, HL
Shu, XO
Chow, WH
Ji, BT
Cai, H
Gao, J
Zhang, W
Gao, YT
Zheng, W
Xiang, YB
AF Vogtmann, Emily
Li, Hong Lan
Shu, Xiao Ou
Chow, Wong Ho
Ji, Bu Tian
Cai, Hui
Gao, Jing
Zhang, Wei
Gao, Yu Tang
Zheng, Wei
Xiang, Yong Bing
TI Dietary glycemic load, glycemic index and risk of primary liver cancer:
Results from the Shanghai women's and men's health studies
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Vogtmann, Emily; Li, Hong Lan; Gao, Jing; Zhang, Wei; Gao, Yu Tang; Xiang, Yong Bing] Shanghai Canc Inst, Shanghai, Peoples R China.
[Shu, Xiao Ou; Cai, Hui; Zheng, Wei] Vanderbilt Univ, Nashville, TN 37235 USA.
[Chow, Wong Ho; Ji, Bu Tian] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 626
DI 10.1158/1538-7445.AM2012-626
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602081
ER
PT J
AU Wang, P
Dong, QZ
Zhang, C
Kuan, PF
Liu, Y
Jeck, WR
Andersen, JB
Auman, JT
Hoskins, JM
Kim, JW
Cibulskis, K
Getz, G
Hunt, HV
Thorgeirsson, SS
Roberts, LR
Ye, D
Guan, KL
Xiong, Y
Qin, LX
Chiang, DY
AF Wang, Pu
Dong, Qiong-Zhu
Zhang, Chong
Kuan, Pei -Fen
Liu, Yufeng
Jeck, William R.
Andersen, Jesper B.
Auman, James Todd
Hoskins, Janelle M.
Kim, Jin Woo
Cibulskis, Kristian
Getz, Gad
Hunt, Heike V.
Thorgeirsson, Snorri S.
Roberts, Lewis R.
Ye, Dan
Guan, Kun-Liang
Xiong, Yue
Qin, Lun-Xiu
Chiang, Derek Y.
TI Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA
hypermethylation in intrahepatic cholangiocarcinomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wang, Pu; Dong, Qiong-Zhu; Ye, Dan; Qin, Lun-Xiu] Fudan Univ, Shanghai 200433, Peoples R China.
[Zhang, Chong; Kuan, Pei -Fen; Liu, Yufeng; Jeck, William R.; Auman, James Todd; Hoskins, Janelle M.; Hunt, Heike V.; Xiong, Yue; Chiang, Derek Y.] Univ N Carolina, Chapel Hill, NC USA.
[Andersen, Jesper B.; Thorgeirsson, Snorri S.] NCI, Bethesda, MD 20892 USA.
[Kim, Jin Woo] Wake Forest Univ, Winston Salem, NC 27109 USA.
[Cibulskis, Kristian; Getz, Gad] Broad Inst, Cambridge, MA USA.
[Roberts, Lewis R.] Mayo Clin, Rochester, MN USA.
[Guan, Kun-Liang] Univ Calif San Diego, San Diego, CA 92103 USA.
[Qin, Lun-Xiu] Zhongshan Hosp, Shanghai, Peoples R China.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1058
DI 10.1158/1538-7445.AM2012-1058
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605053
ER
PT J
AU Watkins, SK
Hurwitz, AA
AF Watkins, Stephanie K.
Hurwitz, Arthur A.
TI Prostate cancer-infiltrating mast cells suppress anti -tumor immunity
through a TGF beta and IL-13 dependent mechanism
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Watkins, Stephanie K.; Hurwitz, Arthur A.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3540
DI 10.1158/1538-7445.AM2011-3540
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500448
ER
PT J
AU Wei, JT
Sanda, MG
Thompson, IM
Partin, A
Feng, ZD
Sokoll, L
Groskopf, J
Brown, E
Lotan, Y
Kibel, A
Lin, D
Taneja, S
Viterbo, R
Busby, E
Bidair, M
Kagan, J
Srivastava, S
AF Wei, John Thomas
Sanda, Martin G.
Thompson, Ian M.
Partin, Alan
Feng, Ziding
Sokoll, Lori
Groskopf, Jack
Brown, Elissa
Lotan, Yair
Kibel, Adam
Lin, Daniel
Taneja, Samir
Viterbo, Rosalia
Busby, Erik
Bidair, Mohamed
Kagan, Jacob
Srivastava, Sudhir
TI The NCI Early Detection Research Network (EDRN) urinary PCA3 validation
trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wei, John Thomas] Univ Michigan, Ann Arbor, MI 48109 USA.
[Sanda, Martin G.] Harvard BID, Boston, MA USA.
[Thompson, Ian M.] UTSA, San Antonio, TX USA.
[Partin, Alan; Sokoll, Lori] Johns Hopkins, Baltimore, MD USA.
[Feng, Ziding; Brown, Elissa] Fred Hutch Canc Res Ctr, Seattle, WA USA.
[Groskopf, Jack] Genprobe, San Diego, CA USA.
[Lotan, Yair] UTSW, Dallas, TX USA.
[Kibel, Adam] Harvard, Boston, MA USA.
[Lin, Daniel] Univ Washington, Seattle, WA 98195 USA.
[Taneja, Samir] NYU, New York, NY USA.
[Viterbo, Rosalia] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
[Busby, Erik] Univ Alabama Birmingham, Birmingham, AL USA.
[Bidair, Mohamed] San Diego Clin Trials, San Diego, CA USA.
[Kagan, Jacob; Srivastava, Sudhir] NCI, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4451
DI 10.1158/1538-7445.AM2012-4451
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701503240
ER
PT J
AU Wentzensen, NA
Killian, K
Adams, L
Luhn, P
Kloor, M
Guido, R
Yang, HP
Garcia-Closas, M
Brinton, L
d'Ambrosio, L
Lissowska, J
Hewitt, S
Meltzer, P
Sherman, M
AF Wentzensen, Nicolas A.
Killian, Keith
Adams, Lisa
Luhn, Patricia
Kloor, Matthias
Guido, Richard
Yang, Hannah P.
Garcia-Closas, Montserrat
Brinton, Louise
d'Ambrosio, Lori
Lissowska, Jolanta
Hewitt, Stephen
Meltzer, Paul
Sherman, Mark
TI DNA methylation profiles of endometrial cancer and benign endometrium
suggest differences by mismatch repair status and possible early
detection markers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wentzensen, Nicolas A.; Luhn, Patricia; Yang, Hannah P.; Brinton, Louise; Sherman, Mark] NCI, DCEG, Bethesda, MD 20892 USA.
[Killian, Keith; Adams, Lisa; Hewitt, Stephen; Meltzer, Paul] NCI, Bethesda, MD 20892 USA.
[Kloor, Matthias] Heidelberg Univ, Heidelberg, Germany.
[Guido, Richard; d'Ambrosio, Lori] UPMC Syst, Magee Womens Hosp, Pittsburgh, PA USA.
[Garcia-Closas, Montserrat] Inst Canc Res, London SW3 6JB, England.
[Lissowska, Jolanta] 6M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland.
[Lissowska, Jolanta] Inst Oncol, Warsaw, Poland.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5012
DI 10.1158/1538-7445.AM2012-5012
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605351
ER
PT J
AU Wheless, LE
Kistner-Griffin, E
Jorgensen, TJ
Ruczinski, I
Berthier-Schaad, Y
Kessing, B
Hoffman-Bolton, J
Woodward, L
Yao, Y
Strickland, PT
Kao, WHL
Alani, RM
Smith, MW
Alberg, AJ
AF Wheless, Lee E.
Kistner-Griffin, Emily
Jorgensen, Timothy J.
Ruczinski, Ingo
Berthier-Schaad, Yvette
Kessing, Bailey
Hoffman-Bolton, Judith
Woodward, Lesley
Yao, Yin
Strickland, Paul T.
Kao, W. H. Linda
Alani, Rhoda M.
Smith, Michael W.
Alberg, Anthony J.
TI A community-based study of nucleotide excision repair polymorphisms in
relation to risk of non-melanoma skin cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wheless, Lee E.; Kistner-Griffin, Emily; Woodward, Lesley; Alberg, Anthony J.] Med Univ S Carolina, Charleston, SC 29425 USA.
[Jorgensen, Timothy J.] Georgetown Univ, Washington, DC USA.
[Ruczinski, Ingo; Berthier-Schaad, Yvette; Strickland, Paul T.; Kao, W. H. Linda] Johns Hopkins Univ, Baltimore, MD USA.
[Kessing, Bailey; Smith, Michael W.] NCI, Lab Genom Divers, Frederick, MD 21701 USA.
[Hoffman-Bolton, Judith] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA.
[Yao, Yin] NIMH, Bethesda, MD 20892 USA.
[Alani, Rhoda M.] Boston Univ, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2639
DI 10.1158/1538-7445.AM2012-2639
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602268
ER
PT J
AU Wiggins, KR
Davis, V
Phadke, D
Shah, R
Archer, TK
AF Wiggins, Kimberly R.
Davis, Valerie
Phadke, Dhiral
Shah, Ruchir
Archer, Trevor K.
TI Inhibition of the ubiquitin proteasome system differentially regulates
glucocorticoid receptor-mediated transcriptional processes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wiggins, Kimberly R.; Davis, Valerie; Archer, Trevor K.] NIEHS, Res Triangle Pk, NC 27709 USA.
[Phadke, Dhiral; Shah, Ruchir] SRA Int Inc, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3928
DI 10.1158/1538-7445.AM2012-3928
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602123
ER
PT J
AU Willard, MD
Wulur, IH
Samuels, Y
Barber, TD
Gartner, J
Parker, SCJ
AF Willard, Melinda D.
Wulur, Isabella H.
Samuels, Yardena
Barber, Thomas D.
Gartner, Jared
Parker, Stephen C. J.
TI Somatic mutations in Pyk2 in melanoma alter protein activity,
interactions and localization
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Willard, Melinda D.; Wulur, Isabella H.; Barber, Thomas D.] Eli Lilly & Co, Indianapolis, IN 46285 USA.
[Samuels, Yardena; Gartner, Jared] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
[Parker, Stephen C. J.] NHGRI, Pharmacol Res Associate Program, NIGMS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 100
DI 10.1158/1538-7445.AM2012-100
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605373
ER
PT J
AU Woditschka, S
Palmieri, D
Duchnowska, R
Jassem, J
Badve, S
Sledge, GW
Steeg, PS
AF Woditschka, Stephan
Palmieri, Diane
Duchnowska, Renata
Jassem, Jacek
Badve, Sunil
Sledge, George W.
Steeg, Patricia S.
TI Overexpression of RAD51 promotes brain metastases from breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Woditschka, Stephan] NCI, Canc Prevent Fellowship Program, Rockville, MD USA.
[Palmieri, Diane; Steeg, Patricia S.] NCI, Womens Canc Sect, Mol Pharmacol Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
[Duchnowska, Renata] Mil Inst Med, Warsaw, Poland.
[Jassem, Jacek] Med Univ Gdansk, Gdansk, Poland.
[Badve, Sunil] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.
[Sledge, George W.] Indiana Univ Sch Med, Dept Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5306
DI 10.1158/1538-7445.AM2012-5306
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504079
ER
PT J
AU Wright, ME
Albanes, D
Shi, F
Moser, A
Virtamo, J
Gann, P
AF Wright, Margaret E.
Albanes, Demetrius
Shi, Fei
Moser, Ann
Virtamo, Jarmo
Gann, Peter
TI Serum phytanic acid and prostate cancer risk: Results from a nested
case-control study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wright, Margaret E.; Shi, Fei; Gann, Peter] Univ Illinois, Chicago, IL USA.
[Albanes, Demetrius] NCI, Bethesda, MD 20892 USA.
[Moser, Ann] Kennedy Krieger Inst, Baltimore, MD USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki, Finland.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4463
DI 10.1158/1538-7445.AM2012-4463
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603291
ER
PT J
AU Wu, J
Keng, V
Patmore, DM
Jousma, E
Eaves, DW
Johansson, G
Schwartz, EB
Fuchs, JR
Dunn, S
Lindquist, D
Dombi, E
Widemann, BC
Stemmer-Rachamimov, AO
Cancelas, JA
Cripe, TP
Largaespada, DA
Ratner, N
AF Wu, Jiangiang
Keng, Vincent
Patmore, Deanna M.
Jousma, Edwin
Eaves, David W.
Johansson, Gunnar
Schwartz, Eric B.
Fuchs, James R.
Dunn, Scott
Lindquist, Diana
Dombi, Eva
Widemann, Brigitte C.
Stemmer-Rachamimov, Anat O.
Cancelas, Jose A.
Cripe, Timothy P.
Largaespada, David A.
Ratner, Nancy
TI An EGFR-STAT3 pathway promotes NF1 peripheral nerve tumorigenesis and
transformation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wu, Jiangiang; Patmore, Deanna M.; Jousma, Edwin; Eaves, David W.; Johansson, Gunnar; Dunn, Scott; Lindquist, Diana; Cancelas, Jose A.; Cripe, Timothy P.; Ratner, Nancy] Cincinnati Childrens Hosp, Cincinnati, OH USA.
[Keng, Vincent; Largaespada, David A.] Univ Minnesota, Minneapolis, MN USA.
[Schwartz, Eric B.; Fuchs, James R.] Ohio State Univ, Columbus, OH 43210 USA.
[Dombi, Eva; Widemann, Brigitte C.] NCI, Bethesda, MD 20892 USA.
[Stemmer-Rachamimov, Anat O.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Stemmer-Rachamimov, Anat O.] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2937
DI 10.1158/1538-7445.AM2012-2937
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602343
ER
PT J
AU Wu, SH
Shu, XO
Chow, WH
Xiang, YB
Zhang, XL
Li, HL
Cai, QY
Milne, G
Ji, BT
Cai, H
Rothman, N
Gao, YT
Zheng, W
Yang, G
AF Wu, Shenghui
Shu, Xiao Ou
Chow, Wong-Ho
Xiang, Yong-Bing
Zhang, Xianglan
Li, Hong-Lan
Cai, Qiuyin
Milne, Ginger
Ji, Bu-Tian
Cai, Hui
Rothman, Nathaniel
Gao, Yu-Tang
Zheng, Wei
Yang, Gong
TI Physical activity and inflammatory and oxidative status markers in
Chinese women
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wu, Shenghui; Shu, Xiao Ou; Zhang, Xianglan; Cai, Qiuyin; Cai, Hui; Zheng, Wei; Yang, Gong] Vanderbilt Univ, Dept Med, Div Epidemiol, Nashville, TN USA.
[Chow, Wong-Ho; Ji, Bu-Tian; Rothman, Nathaniel] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
[Xiang, Yong-Bing; Li, Hong-Lan; Gao, Yu-Tang] Shanghai Canc Inst, Shanghai, Peoples R China.
[Milne, Ginger] Vanderbilt Univ, Dept Med, Div Clin Pharmacol, Nashville, TN USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 627
DI 10.1158/1538-7445.AM2012-627
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602082
ER
PT J
AU Wu, YZ
Lu, JM
Antony, S
Juhasz, A
Liu, H
Jiang, GJ
Roy, K
Doroshow, J
AF Wu, Yongzhong
Lu, Jiamo
Antony, Smitha
Juhasz, Agnes
Liu, Han
Jiang, Guojian
Roy, Krishnendu
Doroshow, James
TI Interferon-alpha induced TLR4 is indispensable for the synergistic
induction of Duox2/DuoxA2 by lipopolysacharide (LPS) and IFN-gamma in
human pancreatic cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Wu, Yongzhong; Lu, Jiamo; Antony, Smitha; Juhasz, Agnes; Liu, Han; Jiang, Guojian; Roy, Krishnendu; Doroshow, James] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3094
DI 10.1158/1538-7445.AM2012-3094
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605121
ER
PT J
AU Xiao, CL
Yaschenko, E
Kimelman, M
Rodarmer, K
Sherry, S
AF Xiao, Chunlin
Yaschenko, Eugene
Kimelman, Mikhail
Rodarmer, Kurt
Sherry, Stephen
TI Evaluation of data compression strategies for genetic variation calling
using next generation sequencing data in normal and tumor samples
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Xiao, Chunlin; Yaschenko, Eugene; Kimelman, Mikhail; Rodarmer, Kurt; Sherry, Stephen] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 3983
DI 10.1158/1538-7445.AM2012-3983
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605086
ER
PT J
AU Xiao, ZX
Jiang, Q
Willette-Brown, J
Zhu, F
Young, HA
Lin, FC
Burkett, S
Datla, M
Xi, SC
Schrump, DS
Wiltrout, RH
Hu, YL
AF Xiao, Zuoxiang
Jiang, Qun
Willette-Brown, Jami
Zhu, Feng
Young, Howard A.
Lin, Fanching
Burkett, Sandra
Datla, Mahesh
Xi, Sichuan
Schrump, David S.
Wiltrout, Robert H.
Hu, Yinling
TI IKK alpha inactivation predisposes to spontaneous lung squamous cell
carcinomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Xiao, Zuoxiang; Jiang, Qun; Willette-Brown, Jami; Zhu, Feng; Young, Howard A.; Lin, Fanching; Burkett, Sandra; Datla, Mahesh; Xi, Sichuan; Schrump, David S.; Wiltrout, Robert H.; Hu, Yinling] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2560
DI 10.1158/1538-7445.AM2012-2560
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600252
ER
PT J
AU Xu, BY
Basuli, F
Wu, H
Salima, A
Opina, A
Lane, K
Griffiths, GL
Jagoda, E
Green, M
Seidel, J
Choyke, P
AF Xu, Biying
Basuli, F.
Wu, H.
Salima, A.
Opina, A.
Lane, K.
Griffiths, G. L.
Jagoda, E.
Green, M.
Seidel, J.
Choyke, P.
TI Long circulating F-18-labeled liposomes for PET imaging
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Xu, Biying; Basuli, F.; Wu, H.; Salima, A.; Opina, A.; Lane, K.; Griffiths, G. L.] NIH, Rockville, MD USA.
[Jagoda, E.; Green, M.; Seidel, J.; Choyke, P.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-420
DI 10.1158/1538-7445.AM2012-LB-420
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501281
ER
PT J
AU Yamashita, T
Honda, M
Kawaguchi, K
Takatori, H
Sunakozaka, H
Wang, XW
Kaneko, S
AF Yamashita, Taro
Honda, Masao
Kawaguchi, Kazunori
Takatori, Hajime
Sunakozaka, Hajime
Wang, Xin W.
Kaneko, Shuichi
TI Distinct liver cancer stem cells defined by EpCAM and CD90 in human
hepatocellular carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yamashita, Taro; Honda, Masao; Kawaguchi, Kazunori; Takatori, Hajime; Sunakozaka, Hajime; Kaneko, Shuichi] Kanazawa Univ, Sch Med, Kanazawa, Ishikawa 920, Japan.
[Wang, Xin W.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5336
DI 10.1158/1538-7445.AM2012-5336
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504111
ER
PT J
AU Yan, S
Thiele, CJ
AF Yan, Shuang
Thiele, Carol J.
TI Validation of potential therapeutic targeting of IL-6/JAK/STAT3 pathway
by AZD1480 in neuroblastoma and other pediatric tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yan, Shuang; Thiele, Carol J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1440
DI 10.1158/1538-7445.AM2012-1440
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701501461
ER
PT J
AU Yang, CZ
Iyer, R
Ikejiri, B
Lonser, R
Zhuang, ZP
AF Yang, Chunzhang
Iyer, Rajiv
Ikejiri, Barbara
Lonser, Russell
Zhuang, Zhengping
TI Beta-catenin signaling initiates the activation of astrocytes and
contributes to the pathogenesis of astrocytomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yang, Chunzhang; Iyer, Rajiv; Ikejiri, Barbara; Lonser, Russell; Zhuang, Zhengping] NINDS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4220
DI 10.1158/1538-7445.AM2012-4220
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504479
ER
PT J
AU Yang, G
Shu, XO
Chow, WH
Zhang, XL
Li, HL
Ji, BT
Cai, H
Wu, SH
Gao, YT
Zheng, W
AF Yang, Gong
Shu, Xiao-Ou
Chow, Wong-Ho
Zhang, Xianglan
Li, Hong-Lan
Ji, Bu-Tian
Cai, Hui
Wu, Sheng-Hui
Gao, Yu-Tang
Zheng, Wei
TI Soy food intake and risk of lung cancer: Evidence from the Shanghai
Women's Health Study and a meta-analysis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yang, Gong; Shu, Xiao-Ou; Zhang, Xianglan; Cai, Hui; Wu, Sheng-Hui; Zheng, Wei] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
[Chow, Wong-Ho; Ji, Bu-Tian] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
[Li, Hong-Lan; Gao, Yu-Tang] Shanghai Canc Inst, Shanghai, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 646
DI 10.1158/1538-7445.AM2012-646
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602102
ER
PT J
AU Yang, ZY
Lu, L
Wang, S
Van Dyke, T
AF Yang, Zhenye
Lu, Lucy
Wang, Sophie
Van Dyke, Terry
TI Aurora-A kinase is required for rapid establishment of the mitotic
checkpoint
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yang, Zhenye; Lu, Lucy; Wang, Sophie; Van Dyke, Terry] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2053
DI 10.1158/1538-7445.AM2012-2053
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701604320
ER
PT J
AU Yoo, SS
Cerna, D
Wilsker, D
Teicher, BA
Coleman, CN
AF Yoo, Stephen S.
Cerna, David
Wilsker, Deborah
Teicher, Beverly A.
Coleman, C. Norman
TI Comparison of radiosensitizing effects of several PARP inhibitors under
clinical investigation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Yoo, Stephen S.; Teicher, Beverly A.; Coleman, C. Norman] NCI, NIH, Bethesda, MD 20892 USA.
[Cerna, David; Wilsker, Deborah] SAIC Frederick Inc, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 1460
DI 10.1158/1538-7445.AM2012-1460
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701502071
ER
PT J
AU Zakharov, AD
Kabirov, KK
Nikolic, D
Chen, L
Mankovskaya, I
van Breemen, RB
Benbrook, DM
Kapetanovic, IM
Lyubimov, AV
AF Zakharov, Alexander D.
Kabirov, Kasim K.
Nikolic, Dejan
Chen, Lian
Mankovskaya, Irina
van Breemen, Richard B.
Benbrook, Doris M.
Kapetanovic, Izet M.
Lyubimov, Alexander V.
TI Analysis of a new chemopreventative agent SHetA2 and its metabolites in
Beagle dog liver and plasma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zakharov, Alexander D.; Kabirov, Kasim K.; Mankovskaya, Irina; Lyubimov, Alexander V.] Univ Illinois, Toxicol Res Lab, Chicago, IL USA.
[Nikolic, Dejan; Chen, Lian; van Breemen, Richard B.] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL USA.
[Benbrook, Doris M.] Univ Oklahoma, Dept Obstet & Gynecol, Oklahoma City, OK USA.
[Benbrook, Doris M.] Univ Oklahoma, Dept Biochem & Mol Biol, Oklahoma City, OK USA.
[Kapetanovic, Izet M.] NCI, Bethesda, MD 20892 USA.
RI Chen, Lian/C-5948-2017
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4781
DI 10.1158/1538-7445.AM2012-4781
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701600040
ER
PT J
AU Zalazar, F
De Luca, P
Elguero, B
Gardner, K
Figg, WD
Meiss, R
Moiola, CP
Cotignola, J
Vazguez, ES
De Siervi, A
AF Zalazar, Florencia
De Luca, Paola
Elguero, Belen
Gardner, Kevin
Figg, William D.
Meiss, Roberto
Moiola, Cristian P.
Cotignola, Javier
Vazguez, Elba S.
De Siervi, Adriana
TI CPS49 and Flavopiridol: a new selective drug combination for advanced
prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zalazar, Florencia; De Luca, Paola; Elguero, Belen; Moiola, Cristian P.; Cotignola, Javier; Vazguez, Elba S.; De Siervi, Adriana] Univ Buenos Aires, Buenos Aires, DF, Argentina.
[Gardner, Kevin; Figg, William D.] NCI, NIH, Bethesda, MD 20892 USA.
[Meiss, Roberto] Acad Nacl Med Buenos Aires, Buenos Aires, DF, Argentina.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2340
DI 10.1158/1538-7445.AM2012-2340
PG 2
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701504291
ER
PT J
AU Zhang, H
Mackall, CL
AF Zhang, Hua
Mackall, Crystal L.
TI Identifying an IDO-expressing "fibrocyte" subset of myeloid suppressor
cells in pediatric cancer patients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhang, Hua; Mackall, Crystal L.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-127
DI 10.1158/1538-7445.AM2012-LB-127
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500252
ER
PT J
AU Zhang, JY
Thorgeirsson, SS
Jessup, JM
AF Zhang, Jingyu
Thorgeirsson, Snorri S.
Jessup, J. Milburn
TI Allele-specific shRNA to Nanog family members inhibits 3-D growth of
colorectal carcinoma through the intrinsic apoptotic pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhang, Jingyu; Thorgeirsson, Snorri S.] NCI, Expt Carcinogenesis Lab, CCR, Bethesda, MD 20892 USA.
[Jessup, J. Milburn] NCI, Canc Diag Prog, DCTD, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5646
DI 10.1158/1538-7445.AM2012-5646
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603311
ER
PT J
AU Zhang, SL
Hong, B
Kopelovich, L
El-Deiry, WS
AF Zhang, Shengliang
Hong, Bo
Kopelovich, Levy
El-Deiry, Wafik S.
TI A novel small molecule p53-pathway restoring compound suppresses
colorectal cancer cells via p73
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhang, Shengliang; Hong, Bo; El-Deiry, Wafik S.] Penn State Hershey Canc Inst, Hershey, PA USA.
[Kopelovich, Levy] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4828
DI 10.1158/1538-7445.AM2012-4828
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602310
ER
PT J
AU Zhang, SY
Zhang, CY
Huang, WC
Lowery, FJ
Huang, SY
Aldape, KD
Steeg, PS
Yu, DH
AF Zhang, Siyuan
Zhang, Chenyu
Huang, Wen-Chien
Lowery, Frank J.
Huang, Suyun
Aldape, Kenneth D.
Steeg, Patricia S.
Yu, Dihua
TI Combating breast cancer brain metastasis by targeting Src family kinases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhang, Siyuan; Zhang, Chenyu; Huang, Wen-Chien; Lowery, Frank J.; Huang, Suyun; Aldape, Kenneth D.; Yu, Dihua] UT MD Anderson Canc Ctr, Houston, TX USA.
[Steeg, Patricia S.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2974
DI 10.1158/1538-7445.AM2012-2974
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701505039
ER
PT J
AU Zhang, YW
Regairaz, M
Seiler, J
Agama, K
Doroshow, J
Pommier, Y
AF Zhang, Yongwei
Regairaz, Marie
Seiler, Jennifer
Agama, Keli
Doroshow, James
Pommier, Yves
TI Rationale for combining PARP inhibitors with topotecan or irinotecan:
taking advantage of the alternative DNA repair pathways involving
XPF-ERCC1 and PARP-TDP1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhang, Yongwei; Regairaz, Marie; Seiler, Jennifer; Agama, Keli; Doroshow, James; Pommier, Yves] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4691
DI 10.1158/1538-7445.AM2012-4691
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603088
ER
PT J
AU Zhao, F
Hoechst, B
Gamrekelashvili, J
Ormandy, L
Voigtlander, T
Wedemeyer, H
Ylaya, K
Hewitt, S
Wang, X
Manns, M
Korangy, F
Greten, T
AF Zhao, Fei
Hoechst, Bastian
Gamrekelashvili, Jaba
Ormandy, Lars
Voigtlaender, Torsten
Wedemeyer, Heiner
Ylaya, Kris
Hewitt, Stephen
Wang, Xin
Manns, Michael
Korangy, Firouzeh
Greten, Tim
TI CCR4+CCR6+Th17 cells suppress autologous CD8+T cell responses in
patients with hepatocellular carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhao, Fei; Gamrekelashvili, Jaba; Ylaya, Kris; Hewitt, Stephen; Wang, Xin; Korangy, Firouzeh; Greten, Tim] NCI, Bethesda, MD 20892 USA.
[Hoechst, Bastian; Ormandy, Lars; Voigtlaender, Torsten; Wedemeyer, Heiner; Manns, Michael] Hannover Med Sch, Hannover, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 5412
DI 10.1158/1538-7445.AM2012-5412
PG 1
WC Oncology
SC Oncology
GA V43SQ
UT WOS:000209701500485
ER
PT J
AU Zhao, XL
Roessler, S
Budhu, A
Yu, ZP
Jia, HL
Ye, QH
Qin, LX
Tang, ZY
Wang, XW
AF Zhao, Xuelian
Roessler, Stephanie
Budhu, Anuradha
Yu, Zhipeng
Jia, Huliang
Ye, Qinghai
Qin, Lunxiu
Tang, Zhaoyou
Wang, Xin Wei
TI An integrative genomic approach uncovers oncogenic roles of
YY1-signaling in hepatocellular carcinoma with stem cell-like traits
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhao, Xuelian; Roessler, Stephanie; Budhu, Anuradha; Yu, Zhipeng; Wang, Xin Wei] NCI, NIH, Bethesda, MD 20892 USA.
[Jia, Huliang; Ye, Qinghai; Qin, Lunxiu; Tang, Zhaoyou] Fudan Univ, Liver Canc Inst, Shanghai 200032, Peoples R China.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA LB-408
DI 10.1158/1538-7445.AM2012-LB-408
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605012
ER
PT J
AU Zheng, YL
Ogundiran, TO
Adebamowo, C
Nathanson, KL
Domchek, SM
Rebbeck, TR
Simon, MS
John, EM
Hennis, A
Nemesure, B
Wu, SY
Leske, MC
Ambs, S
Niu, Q
Zhang, J
Cox, NJ
Olopade, OI
Huo, DZ
AF Zheng, Yonglan
Ogundiran, Temidayo O.
Adebamowo, Clement
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Simon, Michael S.
John, Esther M.
Hennis, Anselm
Nemesure, Barbara
Wu, Suh-Yuh
Leske, M. Cristina
Ambs, Stefan
Niu, Qun
Zhang, Jing
Cox, Nancy J.
Olopade, Olufunmilayo I.
Huo, Dezheng
TI Absence of association between common genetic polymorphisms in the
TERT-CLPTM1L locus and breast cancer risk in women of African descent
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zheng, Yonglan; Niu, Qun; Zhang, Jing; Cox, Nancy J.; Olopade, Olufunmilayo I.; Huo, Dezheng] Univ Chicago, Chicago, IL 60637 USA.
[Ogundiran, Temidayo O.] Univ Ibadan, Ibadan, Nigeria.
[Adebamowo, Clement] Univ Maryland, Baltimore, MD 21201 USA.
[Nathanson, Katherine L.; Domchek, Susan M.; Rebbeck, Timothy R.] Univ Penn, Philadelphia, PA 19104 USA.
[Simon, Michael S.] Wayne State Univ, Detroit, MI USA.
[John, Esther M.] Canc Prevent Inst Calif, Fremont, CA USA.
[Hennis, Anselm] Univ W Indies, Bridgetown, Barbados.
[Nemesure, Barbara; Wu, Suh-Yuh; Leske, M. Cristina] SUNY Stony Brook, Stony Brook, NY 11794 USA.
[Ambs, Stefan] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2606
DI 10.1158/1538-7445.AM2012-2606
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701602230
ER
PT J
AU Zhu, B
Khozoie, C
Ferry, CH
Markell, LM
Bility, MT
Blazanin, N
Glick, AB
Gonzalez, FJ
AF Zhu, Bokai
Khozoie, Combiz
Ferry, Christina H.
Markell, Lauren M.
Bility, Moses T.
Blazanin, Nicholas
Glick, Adam B.
Gonzalez, Frank J.
TI Anti-oncogenic role of peroxisome proliferator-activated
receptor-alpha/beta (PPAR delta/alpha) involves inhibition of mitosis
and regulation of Hras1-induced senescence
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zhu, Bokai; Khozoie, Combiz; Ferry, Christina H.; Markell, Lauren M.; Bility, Moses T.; Blazanin, Nicholas; Glick, Adam B.] Penn State Univ, University Pk, PA 16802 USA.
[Gonzalez, Frank J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2172
DI 10.1158/1538-7445.AM2012-2172
PG 1
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701606152
ER
PT J
AU Zoppoli, G
Solier, S
Reinhold, WC
Liu, HF
Connelly, JW
Monks, A
Shoemaker, RH
Abaan, OD
Davis, SR
Piras, D
Ballestrero, A
Meltzer, PS
Doroshow, JH
Pommier, Y
AF Zoppoli, Gabriele
Solier, Stephanie
Reinhold, William C.
Liu, Hongfang
Connelly, John W.
Monks, Anne
Shoemaker, Robert H.
Abaan, Ogan D.
Davis, Sean R.
Piras, Daniela
Ballestrero, Alberto
Meltzer, Paul S.
Doroshow, James H.
Pommier, Yves
TI CHEK2 (Chk2) endogenous activation is associated with p53 deficiency and
downregulation of BRCA2 and Fanconi Anemia pathway gene members in the
National Cancer Institute Anticancer Tumor Cell Line Panel (NCI-60)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zoppoli, Gabriele; Piras, Daniela; Ballestrero, Alberto] Univ Genoa, Genoa, Italy.
[Solier, Stephanie; Reinhold, William C.; Abaan, Ogan D.; Davis, Sean R.; Meltzer, Paul S.; Doroshow, James H.; Pommier, Yves] NIH, Bethesda, MD 20892 USA.
[Liu, Hongfang] Mayo Clin, Div Biomed Stat & Infomat, Rochester, MN USA.
[Connelly, John W.; Monks, Anne; Shoemaker, Robert H.] NIH, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 2116
DI 10.1158/1538-7445.AM2012-2116
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701605160
ER
PT J
AU Zoppoli, G
Regairaz, M
Leo, E
Reinhold, WC
Pommier, Y
AF Zoppoli, Gabriele
Regairaz, Marie
Leo, Elisabetta
Reinhold, William C.
Pommier, Yves
TI The putative DNA/RNA Helicase Schlafen-11 sensitizes cancer cells to
topoisomerase I inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Zoppoli, Gabriele] Univ Genoa, Genoa, Italy.
[Regairaz, Marie; Leo, Elisabetta; Reinhold, William C.; Pommier, Yves] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD APR 15
PY 2012
VL 72
SU 8
MA 4693
DI 10.1158/1538-7445.AM2012-4693
PG 2
WC Oncology
SC Oncology
GA V43SR
UT WOS:000209701603090
ER
PT J
AU Zhu, XM
Ahmad, SM
Aboukhalil, A
Busser, BW
Kim, Y
Tansey, TR
Haimovich, A
Jeffries, N
Bulyk, ML
Michelson, AM
AF Zhu, Xianmin
Ahmad, Shaad M.
Aboukhalil, Anton
Busser, Brian W.
Kim, Yongsok
Tansey, Terese R.
Haimovich, Adrian
Jeffries, Neal
Bulyk, Martha L.
Michelson, Alan M.
TI Differential regulation of mesodermal gene expression by Drosophila cell
type-specific Forkhead transcription factors
SO DEVELOPMENT
LA English
DT Article
DE Transcription factors; Transcription factor binding sites; Forkhead
proteins; Transcriptional regulation; Enhancers; Mesoderm
ID VISCERAL MESODERM; DIRECT TARGET; BETA-3-TUBULIN GENE; HEART
DEVELOPMENT; DORSAL VESSEL; TINMAN; PROTEIN; MELANOGASTER; INTEGRATION;
BINIOU
AB A common theme in developmental biology is the repeated use of the same gene in diverse spatial and temporal domains, a process that generally involves transcriptional regulation mediated by multiple separate enhancers, each with its own arrangement of transcription factor (TF)-binding sites and associated activities. Here, by contrast, we show that the expression of the Drosophila Nidogen (Ndg) gene at different embryonic stages and in four mesodermal cell types is governed by the binding of multiple cell-specific Forkhead (Fkh) TFs - including Biniou (Bin), Checkpoint suppressor homologue (CHES-1-like) and Jumeau (Jumu) - to three functionally distinguishable Fkh-binding sites in the same enhancer. Whereas Bin activates the Ndg enhancer in the late visceral musculature, CHES-1-like cooperates with Jumu to repress this enhancer in the heart. CHES-1-like also represses the Ndg enhancer in a subset of somatic myoblasts prior to their fusion to form multinucleated myotubes. Moreover, different combinations of Fkh sites, corresponding to two different sequence specificities, mediate the particular functions of each TF. A genome-wide scan for the occurrence of both classes of Fkh domain recognition sites in association with binding sites for known cardiac TFs showed an enrichment of combinations containing the two Fkh motifs in putative enhancers found within the noncoding regions of genes having heart expression. Collectively, our results establish that different cell-specific members of a TF family regulate the activity of a single enhancer in distinct spatiotemporal domains, and demonstrate how individual binding motifs for a TF class can differentially influence gene expression.
C1 [Zhu, Xianmin; Ahmad, Shaad M.; Busser, Brian W.; Kim, Yongsok; Tansey, Terese R.; Haimovich, Adrian; Michelson, Alan M.] NHLBI, Lab Dev Syst Biol, Genet & Dev Biol Ctr, NIH, Bethesda, MD 20892 USA.
[Aboukhalil, Anton; Bulyk, Martha L.] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.
[Aboukhalil, Anton; Bulyk, Martha L.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
[Aboukhalil, Anton] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA.
[Jeffries, Neal] NHLBI, Off Biostat Res, NIH, Bethesda, MD 20892 USA.
[Bulyk, Martha L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.
[Bulyk, Martha L.] Harvard Univ, Sch Med, Harvard MIT Div Hlth Sci & Technol HST, Boston, MA 02115 USA.
RP Michelson, AM (reprint author), NHLBI, Lab Dev Syst Biol, Genet & Dev Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA.
EM michelsonam@mail.nih.gov
OI Ahmad, Shaad/0000-0001-5373-1710
FU National Heart, Lung, and Blood Institute (NHLBI) Division of Intramural
Research; National Institutes of Health (NIH) [R01 HG005287-01A1];
American Heart Association
FX This work was supported by the National Heart, Lung, and Blood Institute
(NHLBI) Division of Intramural Research (A.M.M.), by the National
Institutes of Health (NIH) [R01 HG005287-01A1 to M.L.B.], by an American
Heart Association Predoctoral Fellowship (A.A.) and by an American Heart
Association Postdoctoral Fellowship (S.M.A.). Deposited in PMC for
immediate release.
NR 66
TC 13
Z9 14
U1 0
U2 3
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 0950-1991
J9 DEVELOPMENT
JI Development
PD APR 15
PY 2012
VL 139
IS 8
BP 1457
EP 1466
DI 10.1242/dev.069005
PG 10
WC Developmental Biology
SC Developmental Biology
GA 914JG
UT WOS:000301945100011
PM 22378636
ER
PT J
AU Porras, C
Wentzensen, N
Rodriguez, AC
Morales, J
Burk, RD
Alfaro, M
Hutchinson, M
Herrero, R
Hildesheim, A
Sherman, ME
Wacholder, S
Solomon, D
Schiffman, M
AF Porras, Carolina
Wentzensen, Nicolas
Rodriguez, Ana C.
Morales, Jorge
Burk, Robert D.
Alfaro, Mario
Hutchinson, Martha
Herrero, Rolando
Hildesheim, Allan
Sherman, Mark E.
Wacholder, Sholom
Solomon, Diane
Schiffman, Mark
TI Switch from cytology-based to human papillomavirus test-based cervical
screening: implications for colposcopy
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE HPV testing; cytology; colposcopy; cervical cancer screening;
cervicography
ID INTRAEPITHELIAL NEOPLASIA; INTEROBSERVER AGREEMENT; PREDICTIVE VALUES;
FOLLOW-UP; HIGH-RISK; CANCER; DNA; WOMEN; STRATEGIES; INFECTION
AB Human papillomavirus (HPV) testing is more sensitive than cytology; some cervical cancer prevention programs will switch from cytology to carcinogenic HPV test-based screening. The objective of our study is to evaluate the clinical implications of a switch to HPV test-based screening on performance and workload of colposcopy. Women in the population-based, 7-year Guanacaste cohort study were screened at enrollment using cytology. We also took another specimen for HPV DNA testing and collected magnified cervical photographic images (cervigrams). A final case diagnosis (>= cervical intraepithelial neoplasia [CIN] grade 3, CIN2, = CIN2 and >= CIN3. A program based on immediate colposcopic referral after positive HPV would immediately identify as high risk more of the cumulative >= CIN2 cases than conventional cytology, because of an increased number of referrals. However, the proportion of women that would have visible lesions at referral to colposcopy and the sensitivity versus specificity trade-off of the colposcopic impressions would be similar to programs using cytology (>= atypical squamous cells of unknown significance [ASCUS]) for referral. The major concern with switching from cytology to more sensitive HPV screening is management of the many HPV-positive women, including those with still nonvisible >= CIN2 lesions. Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV-positive women.
C1 [Porras, Carolina; Rodriguez, Ana C.; Morales, Jorge; Alfaro, Mario; Herrero, Rolando] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica.
[Porras, Carolina; Wentzensen, Nicolas; Hildesheim, Allan; Sherman, Mark E.; Wacholder, Sholom; Solomon, Diane; Schiffman, Mark] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Burk, Robert D.] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10467 USA.
[Hutchinson, Martha] Brown Univ, Women & Infants Hosp, Providence, RI USA.
RP Porras, C (reprint author), Fdn INCIENSA, Proyecto Epidemiol Guanacaste, 300 Mts Oeste ICE Piso 7, San Jose, Costa Rica.
EM cporras@proyectoguanacaste.org
RI perumal, murugiah/D-1565-2012; Hildesheim, Allan/B-9760-2015
OI Hildesheim, Allan/0000-0003-0257-2363
FU National Institutes of Health [N01-CP-21081, N01-CP-33061, N01-CP-40542,
N01-CP-50535, N01-CP-81023, CA78527]; National Cancer Institute,
National Institutes of Health, Department of Health and Human Services
FX Grant sponsor: National Institutes of Health; Grant numbers:
N01-CP-21081, N01-CP-33061, N01-CP-40542, N01-CP-50535 and N01-CP-81023;
Grant sponsor: Intramural Program of NIH; Grant number: CA78527; Grant
sponsors: National Cancer Institute, National Institutes of Health,
Department of Health and Human Services and Senior Fellowship Program,
National Institutes of Health
NR 26
TC 9
Z9 12
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 15
PY 2012
VL 130
IS 8
BP 1879
EP 1887
DI 10.1002/ijc.26194
PG 9
WC Oncology
SC Oncology
GA 897WV
UT WOS:000300692300018
PM 21607948
ER
PT J
AU Guech-Ongey, M
Yagi, M
Palacpac, NMQ
Emmanuel, B
Talisuna, AO
Bhatia, K
Stefan, DC
Biggar, RJ
Nkrumah, F
Neequaye, J
Tougan, T
Horii, T
Mbulaiteye, SM
AF Guech-Ongey, Mercy
Yagi, Masanori
Palacpac, Nirianne Marie Q.
Emmanuel, Benjamin
Talisuna, Ambrose O.
Bhatia, Kishor
Stefan, D. Cristina
Biggar, Robert J.
Nkrumah, Francis
Neequaye, Janet
Tougan, Takahiro
Horii, Toshihiro
Mbulaiteye, Sam M.
TI Antibodies reactive to Plasmodium falciparum serine repeat antigen in
children with Burkitt lymphoma from Ghana
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE Plasmodium falciparum malaria; Africa; Epstein-Barr virus; immunity;
epidemiology
ID EPSTEIN-BARR-VIRUS; MALARIA; SERA; IMMUNITY; STABILITY; INFECTION;
CORRELATE; PROTEINS; UGANDA
AB The role of protective immunity to Plasmodium falciparum (Pf) malaria in Burkitt lymphoma (BL) is unknown. We investigated the association between BL and antibodies reactive to SE36 antigen, a recombinant protein based on P. falciparum serine repeat antigen 5 gene, targeted by protective malaria immune responses. Cases were children (0-14 years) enrolled at the Korle-Bu Teaching Hospital, Accra, Ghana, during 1965-1994 with BL confirmed by histology or cytology (92% of cases). Controls were apparently healthy children enrolled contemporaneous to the cases from the nearest neighbor house to the case house and were age,- sex-frequency-matched to the cases. Anti-SE36 IgG antibodies were measured using enzyme-linked absorbent immunoassays (ELISAs). SE36 titers were estimated by extrapolating ELISA optical density readings to a standard fitting curve. Anti-SE36 titers were log-transformed for analysis. Odds ratios (ORs) and two-sided 95% confidence intervals (95% CIs) were estimated using unconditional logistic regression. The mean log endpoint dilution titers were 0.63 logs lower in cases than in controls (8.26 [SD 1.68] vs. 8.89 [SD 1.75], Student's t-test, p = 0.019). Lower titers were observed in cases than controls aged 0-4 years (p = 0.05) and in those aged 5-14 years (p = 0.06). Low and medium tertiles of anti-SE36 IgG antibodies were associated with increased OR for BL ([OR 1.67, 95% CI 1.21-2.31] and [OR 1.33, 95% CI 0.96-1.86], respectively, p(trend) = 0.002) in analyses adjusting for age, sex, calendar period and test plate. Our findings suggest that compared to similarly aged children enrolled from the same community, children with BL in Ghana have lower antibodies to SE36 antigen.
C1 [Guech-Ongey, Mercy; Emmanuel, Benjamin; Bhatia, Kishor; Mbulaiteye, Sam M.] NCI, Div Canc Epidemiol & Genet, DCEG, Bethesda, MD 20892 USA.
[Yagi, Masanori; Palacpac, Nirianne Marie Q.; Tougan, Takahiro; Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Osaka, Japan.
[Talisuna, Ambrose O.] Uganda Minist Hlth, Infect Dis Res Collaborat, Kampala, Uganda.
[Stefan, D. Cristina] Univ Stellenbosch, Dept Pediat & Child Hlth, Cape Town, South Africa.
[Nkrumah, Francis] Univ Ghana, Noguchi Mem Inst, Legon, Ghana.
[Neequaye, Janet] Korle Bu Univ Teaching Hosp Accra, Dept Child Hlth, Accra, Ghana.
RP Mbulaiteye, SM (reprint author), 6120 Execut Blvd,Execut Plaza S,Room 7080,MSC 724, Rockville, MD 20852 USA.
EM mbulaits@mail.nih.gov
FU National Cancer Institute, National Institutes of Health, Department of
Health and Human Services [N01-CO-12400]; Ministry of Education,
Culture, Sports, Science and Technology (MEXT) of Japan
FX Grant sponsor: National Cancer Institute, National Institutes of Health,
Department of Health and Human Services (Intramural Research Program of
the Division of Cancer Epidemiology and Genetics); Support Services
Contract number: N01-CO-12400; Grant sponsor: Ministry of Education,
Culture, Sports, Science and Technology (MEXT) of Japan (Biomedical
Kansai project supported by the Regional Innovation Cluster Program)
NR 30
TC 4
Z9 4
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 15
PY 2012
VL 130
IS 8
BP 1908
EP 1914
DI 10.1002/ijc.26203
PG 7
WC Oncology
SC Oncology
GA 897WV
UT WOS:000300692300021
PM 21630256
ER
PT J
AU Farsaci, B
Higgins, JP
Hodge, JW
AF Farsaci, Benedetto
Higgins, Jack P.
Hodge, James W.
TI Consequence of dose scheduling of sunitinib on host immune response
elements and vaccine combination therapy
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE sunitinib; vaccine; immunotherapy; TKI; cancer
ID RENAL-CELL CARCINOMA; TYROSINE KINASE INHIBITOR; HUMAN
CARCINOEMBRYONIC-ANTIGEN; SUPPRESSOR-CELLS; TUMOR MICROENVIRONMENT;
CANCER; IDENTIFICATION; SORAFENIB; REVERSAL; MALATE
AB Our study investigated the immunomodulatory effects of sunitinib to rationally design combinational platforms with immunotherapies for the treatment of solid tumors. Using a mouse model, we studied the effects of sunitinib given for 4 weeks at concentrations comparable to 37.5-50 mg/day in humans, followed by 2 weeks off the drug (sunitinib 4/2). We assessed the effect of differently timed combinations of sunitinib and a poxvirus-based vaccine encoding carcinoembryonic antigen (CEA) plus 3 costimulatory molecules on immune responses in CEA-transgenic (CEA-Tg) mice. Antitumor studies were performed in CEA-Tg mice bearing CEA-transfected MC38 murine colon carcinomas (MC38-CEA), treated either concurrently or sequentially with sunitinib and vaccine. In vitro, sunitinib inhibited PDGFR phosphorylation on MC38-CEA cells at concentrations similar to those biologically available during human treatment. In vivo, one cycle of sunitinib 4/2 caused bimodal immune effects: (a) decreased regulatory cells during the 4 weeks of treatment and (b) an immune-suppression rebound during the 2 weeks of treatment interruption. In a model using CEA-Tg mice bearing CEA(+) tumors, continuous sunitinib followed by vaccine increased intratumoral infiltration of antigen-specific T lymphocytes, decreased immunosuppressant T regulatory cells and myeloid-derived suppressor cells, reduced tumor volumes and increased survival. The immunomodulatory activity of continuous sunitinib administration can create a more immune-permissive environment. In combination with immunotherapies, sunitinib treatment should precede vaccine, to precondition the immune system, to maximize the response to vaccine-mediated immune enhancement.
C1 [Farsaci, Benedetto; Higgins, Jack P.; Hodge, James W.] NCI, Lab Tumor Immunol & Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Hodge, JW (reprint author), NCI, Lab Tumor Immunol & Biol, Ctr Canc Res, NIH, 10 Ctr Dr,Room 8B09, Bethesda, MD 20892 USA.
EM jh241d@nih.gov
RI Farsaci, Benedetto/L-9837-2014; Hodge, James/D-5518-2015
OI Farsaci, Benedetto/0000-0001-8275-2561; Hodge, James/0000-0001-5282-3154
FU Center for Cancer Research, National Cancer Institute, NIH
FX Grant sponsor: Intramural Research Program of the Center for Cancer
Research, National Cancer Institute, NIH
NR 32
TC 53
Z9 53
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD APR 15
PY 2012
VL 130
IS 8
BP 1948
EP 1959
DI 10.1002/ijc.26219
PG 12
WC Oncology
SC Oncology
GA 897WV
UT WOS:000300692300025
PM 21633954
ER
PT J
AU Jahouh, F
Hou, SJ
Kovac, P
Banoub, JH
AF Jahouh, Farid
Hou, Shu-jie
Kovac, Pavol
Banoub, Joseph H.
TI Determination of glycation sites by tandem mass spectrometry in a
synthetic lactose-bovine serum albumin conjugate, a vaccine model
prepared by dialkyl squarate chemistry
SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY
LA English
DT Article
ID VIBRIO-CHOLERAE O-1; SEROTYPE OGAWA; O-PS; DIETHYL SQUARATE; PROTEINS;
OLIGOSACCHARIDES; NOMENCLATURE; PEPTIDES; PROGRESS; SPECTRA
AB RATIONALE: Neoglycoconjugate vaccines synthesized by the squaric acid spacer method allow single point attachment of the carbohydrate antigen to the protein carrier. However, the localization of the carbohydrate antigen sites of conjugation on the protein carrier has been an elusive task difficult to achieve.
METHOD: Covalent attachment of the lactose antigen to the bovine serum albumin (BSA) was prepared by the squaric acid method using a hapten: BSA ratio of 20: 1. Different reaction times were used during the conjugation reaction and two different lactose-BSA glycoconjugate vaccines were obtained. The carbohydrate antigen hapten: BSA ratios of these lactose-BSA glycoconjugate vaccines were determined by MALDI-TOF/ RTOF-MS and the glycation sites in the neoglycoconjugates were determined using nano-LC/ ESI-QqTOF-MS/ MS analysis of the trypsin and GluC V8 digests of the conjugates.
RESULTS: We have identified a total of 15 glycation sites located on the BSA lysine residues for the neoglycoconjugate vaccine formed with a hapten: BSA ratio of 5.1: 1, However, the tryptic and GluC V8 digests of the hapten-BSA glycoconjugate with a hapten: BSA ratio of 19.0: 1 allowed identification of 30 glycation sites located on the BSA. These last results seem to indicate that this conjugation results in formation of various glycoforms.
CONCLUSIONS: It was observed that the number of identified glycation sites increasedwhen the hapten: BSA ratio of glycoconjugate formation increased, and that the location of the glycation sites appears to be mainly on the outer surface of the BSA carrier molecule which is in line with the assumption that the sterically more accessible lysine residues, namely those located on the outer surface of the BSA, would be conjugated preferentially. Copyright (C)2012 John Wiley & Sons, Ltd.
C1 [Banoub, Joseph H.] Dept Fisheries & Oceans Canada, Sci Branch, Special Projects, St John, NF A1C 5X1, Canada.
[Jahouh, Farid; Banoub, Joseph H.] Mem Univ Newfoundland, Dept Chem, St John, NF A1B 3X7, Canada.
[Hou, Shu-jie; Kovac, Pavol] NIDDK, LBC, NIH, Bethesda, MD 20892 USA.
RP Banoub, JH (reprint author), Dept Fisheries & Oceans Canada, Sci Branch, Special Projects, St John, NF A1C 5X1, Canada.
EM banoubjo@dfo-mpo.gc.ca
FU Intramural NIH HHS [ZIA DK059701-38]
NR 24
TC 6
Z9 6
U1 2
U2 14
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0951-4198
J9 RAPID COMMUN MASS SP
JI Rapid Commun. Mass Spectrom.
PD APR 15
PY 2012
VL 26
IS 7
BP 749
EP 758
DI 10.1002/rcm.6166
PG 10
WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy
SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy
GA 898EO
UT WOS:000300719100005
PM 22368054
ER
PT J
AU Saunders, RC
Vann, SD
Aggleton, JP
AF Saunders, Richard C.
Vann, Seralynne D.
Aggleton, John P.
TI Projections from Gudden's tegmental nuclei to the mammillary body region
in the cynomolgus monkey (Macaca fascicularis)
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE amnesia; head-direction; hypothalamus; memory; primate; raphe nucleus;
tegmentum
ID HORSERADISH-PEROXIDASE; EFFERENT CONNECTIONS; SUPRAMAMMILLARY NUCLEUS;
HIPPOCAMPAL-FORMATION; ANTERIOR THALAMUS; PREFRONTAL CORTEX; MACAQUE
MONKEYS; CEREBRAL-CORTEX; MAMILLARY BODY; RHESUS-MONKEY
AB Gudden's tegmental nuclei provide major inputs to the rodent mammillary bodies, where they are thought to be important for learning and navigation. Comparable projections have yet to be described in the primate brain, where part of the problem has been in effectively delineating these nuclei. Immunohistochemical staining of tissue from a series of macaque monkeys (Macaca mulatta) showed that cells in the region of both the ventral and dorsal tegmental nuclei selectively stain for parvalbumin, thus helping to reveal these nuclei. These same tegmental nuclei were not selectively revealed when tissue was stained for SMI32, acetylcholinesterase, calbindin, or calretinin. In a parallel study, horseradish peroxidase was injected into the mammillary bodies of five cynomolgus monkeys (Macaca fascicularis). Retrogradely labeled neurons were consistently found in the three subdivisions of the ventral tegmental nucleus of Gudden, which are located immediately below, within, and above the medial longitudinal fasciculus. Further projections to the mammillary body region arose from cells in the anterior tegmental nucleus, which appears to be a rostral continuation of the infrafascicular part of the ventral tegmental nucleus. In the dorsal tegmental nucleus of Gudden, labeled cells were most evident when the tracer injection was more laterally placed in the mammillary bodies, consistent with a projection to the lateral mammillary nucleus. The present study not only demonstrates that the primate mammillary bodies receive parallel inputs from the dorsal and ventral tegmental nuclei of Gudden, but also helps to confirm the extent of these poorly distinguished nuclei in the monkey brain. J. Comp. Neurol. 520:11281145, 2012. (C) 2011 Wiley Periodicals, Inc.
C1 [Vann, Seralynne D.; Aggleton, John P.] Cardiff Univ, Sch Psychol, Cardiff CF10 3AT, S Glam, Wales.
[Saunders, Richard C.] NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA.
RP Aggleton, JP (reprint author), Cardiff Univ, Sch Psychol, Pk Pl, Cardiff CF10 3AT, S Glam, Wales.
EM aggleton@cf.ac.uk
RI Vann, Seralynne/A-1601-2010;
OI Vann, Seralynne/0000-0002-6709-8773; Aggleton, John/0000-0002-5573-1308
FU Royal Society; Wolfson Trust; National Institute of Mental Health
FX Grant sponsors: The Royal Society, the Wolfson Trust, National Institute
of Mental Health Intramural Research Program.
NR 59
TC 11
Z9 11
U1 1
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9967
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD APR 15
PY 2012
VL 520
IS 6
BP 1128
EP 1145
DI 10.1002/cne.22740
PG 18
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA 887RV
UT WOS:000299947900002
PM 21830220
ER
PT J
AU Weinberger, DM
Malley, R
Lipsitch, M
AF Weinberger, Daniel M.
Malley, Richard
Lipsitch, Marc
TI Serotype replacement after pneumococcal vaccination Reply
SO LANCET
LA English
DT Letter
ID DISEASE
C1 [Weinberger, Daniel M.; Lipsitch, Marc] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
[Malley, Richard] Childrens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA.
[Malley, Richard] Harvard Univ, Sch Med, Boston, MA 02115 USA.
[Weinberger, Daniel M.] NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Weinberger, DM (reprint author), Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, 665 Huntington Ave, Boston, MA 02115 USA.
EM dweinber@gmail.com
NR 4
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD APR 14
PY 2012
VL 379
IS 9824
BP 1388
EP 1389
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 926BR
UT WOS:000302806800020
ER
PT J
AU Bhardwaj, G
Ko, KD
Hong, YJ
Zhang, ZH
Ho, NL
Chintapalli, SV
Kline, LA
Gotlin, M
Hartranft, DN
Patterson, ME
Dave, F
Smith, EJ
Holmes, EC
Patterson, RL
van Rossum, DB
AF Bhardwaj, Gaurav
Ko, Kyung Dae
Hong, Yoojin
Zhang, Zhenhai
Ho, Ngai Lam
Chintapalli, Sree V.
Kline, Lindsay A.
Gotlin, Matthew
Hartranft, David Nicholas
Patterson, Morgen E.
Dave, Foram
Smith, Evan J.
Holmes, Edward C.
Patterson, Randen L.
van Rossum, Damian B.
TI PHYRN: A Robust Method for Phylogenetic Analysis of Highly Divergent
Sequences
SO PLOS ONE
LA English
DT Article
ID MULTIPLE ALIGNMENT; TWILIGHT ZONE; MIXED MODELS; PROTEIN; TREES;
EVOLUTION; RECONSTRUCTION; INFERENCE; DANGER; MATRIX
AB Both multiple sequence alignment and phylogenetic analysis are problematic in the "twilight zone" of sequence similarity (<= 25% amino acid identity). Herein we explore the accuracy of phylogenetic inference at extreme sequence divergence using a variety of simulated data sets. We evaluate four leading multiple sequence alignment (MSA) methods (MAFFT, T-COFFEE, CLUSTAL, and MUSCLE) and six commonly used programs of tree estimation (Distance-based: Neighbor-Joining; Character-based: PhyML, RAxML, GARLI, Maximum Parsimony, and Bayesian) against a novel MSA-independent method (PHYRN) described here. Strikingly, at "midnight zone" genetic distances (similar to 7% pairwise identity and 4.0 gaps per position), PHYRN returns high-resolution phylogenies that outperform traditional approaches. We reason this is due to PHRYN's capability to amplify informative positions, even at the most extreme levels of sequence divergence. We also assess the applicability of the PHYRN algorithm for inferring deep evolutionary relationships in the divergent DANGER protein superfamily, for which PHYRN infers a more robust tree compared to MSA-based approaches. Taken together, these results demonstrate that PHYRN represents a powerful mechanism for mapping uncharted frontiers in highly divergent protein sequence data sets.
C1 [Bhardwaj, Gaurav; Ko, Kyung Dae; Hong, Yoojin; Zhang, Zhenhai; Ho, Ngai Lam; Kline, Lindsay A.; Gotlin, Matthew; Hartranft, David Nicholas; Patterson, Morgen E.; Dave, Foram; Smith, Evan J.; Patterson, Randen L.; van Rossum, Damian B.] Penn State Univ, Ctr Computat Prote, University Pk, PA 16802 USA.
[Bhardwaj, Gaurav; Ko, Kyung Dae; Hong, Yoojin; Kline, Lindsay A.; Gotlin, Matthew; Hartranft, David Nicholas; Smith, Evan J.; Holmes, Edward C.; van Rossum, Damian B.] Penn State Univ, Dept Biol, University Pk, PA 16802 USA.
[Hong, Yoojin; Ho, Ngai Lam] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
[Zhang, Zhenhai] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA.
[Holmes, Edward C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
[Bhardwaj, Gaurav; Patterson, Randen L.] Univ Calif Davis, Dept Biochem & Mol Med, Sch Med, Davis, CA 95616 USA.
[Chintapalli, Sree V.; Patterson, Randen L.] Univ Calif Davis, Dept Physiol & Membrane Biol, Sch Med, Davis, CA 95616 USA.
[Bhardwaj, Gaurav; Chintapalli, Sree V.; Patterson, Randen L.; van Rossum, Damian B.] Univ Calif Davis, Ctr Translat Biosci & Comp, Davis, CA 95616 USA.
RP Bhardwaj, G (reprint author), Penn State Univ, Ctr Computat Prote, University Pk, PA 16802 USA.
EM randen100@gmail.com; dbv10@psu.edu
OI Patterson, Morgen/0000-0003-4660-2755; Holmes,
Edward/0000-0001-9596-3552
FU Searle Young Investigators Award; PSU; NCSA [TG-MCB070027N]; National
Science Foundation [428-15 691M]; National Institutes of Health [R01
GM087410-01]; Fellowship from the Eberly College of Sciences; Huck
Institutes of the Life Sciences; Pennsylvania Department of Health using
Tobacco Settlement Funds
FX This work was supported by the Searle Young Investigators Award and
start-up money from PSU (RLP), NCSA grant TG-MCB070027N (RLP, DVR), The
National Science Foundation 428-15 691M (RLP, DVR), and The National
Institutes of Health R01 GM087410-01 (RLP, DVR). This project was also
funded by a Fellowship from the Eberly College of Sciences and the Huck
Institutes of the Life Sciences (DVR) and a grant with the Pennsylvania
Department of Health using Tobacco Settlement Funds (DVR). The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 56
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Z9 8
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2012
VL 7
IS 4
AR e34261
DI 10.1371/journal.pone.0034261
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UT
UT WOS:000305341600032
PM 22514627
ER
PT J
AU Zajdowicz, S
Haller, JC
Krafft, AE
Hunsucker, SW
Mant, CT
Duncan, MW
Hodges, RS
Jones, DNM
Holmes, RK
AF Zajdowicz, Sheryl
Haller, Jon C.
Krafft, Amy E.
Hunsucker, Steve W.
Mant, Colin T.
Duncan, Mark W.
Hodges, Robert S.
Jones, David N. M.
Holmes, Randall K.
TI Purification and Structural Characterization of Siderophore
(Corynebactin) from Corynebacterium diphtheriae
SO PLOS ONE
LA English
DT Article
ID MICROBIAL IRON TRANSPORT; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI;
COORDINATION CHEMISTRY; BACILLUS-SUBTILIS; STAPHYLOFERRIN-A;
GENE-CLUSTER; GLUTAMICUM; NMR; BIOSYNTHESIS
AB During infection, Corynebacterium diphtheriae must compete with host iron-sequestering mechanisms for iron. C. diphtheriae can acquire iron by a siderophore-dependent iron-uptake pathway, by uptake and degradation of heme, or both. Previous studies showed that production of siderophore (corynebactin) by C. diphtheriae is repressed under high-iron growth conditions by the iron-activated diphtheria toxin repressor (DtxR) and that partially purified corynebactin fails to react in chemical assays for catecholate or hydroxamate compounds. In this study, we purified corynebactin from supernatants of low-iron cultures of the siderophore-overproducing, DtxR-negative mutant strain C. diphtheriae C7(beta) Delta dtxR by sequential anion-exchange chromatography on AG1-X2 and Source 15Q resins, followed by reverse-phase high-performance liquid chromatography (RP-HPLC) on Zorbax C8 resin. The Chrome Azurol S (CAS) chemical assay for siderophores was used to detect and measure corynebactin during purification, and the biological activity of purified corynebactin was shown by its ability to promote growth and iron uptake in siderophore-deficient mutant strains of C. diphtheriae under iron-limiting conditions. Mass spectrometry and NMR analysis demonstrated that corynebactin has a novel structure, consisting of a central lysine residue linked through its alpha- and epsilon-amino groups by amide bonds to the terminal carboxyl groups of two different citrate residues. Corynebactin from C. diphtheriae is structurally related to staphyloferrin A from Staphylococcus aureus and rhizoferrin from Rhizopus microsporus in which D-ornithine or 1,4-diaminobutane, respectively, replaces the central lysine residue that is present in corynebactin.
C1 [Zajdowicz, Sheryl; Haller, Jon C.; Holmes, Randall K.] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO USA.
[Zajdowicz, Sheryl] Metropolitan State Coll Denver, Dept Biol, Denver, CO USA.
[Krafft, Amy E.] NIAID, Resp Dis Branch, Div Microbiol & Infect Dis, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Hunsucker, Steve W.; Duncan, Mark W.] Univ Colorado, Sch Med, Dept Endocrinol Metab & Diabet, Aurora, CO USA.
[Mant, Colin T.; Hodges, Robert S.] Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO USA.
[Jones, David N. M.] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA.
RP Zajdowicz, S (reprint author), Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO USA.
EM Randall.Holmes@ucdenver.edu
RI Jones, David/C-5764-2013
FU NIH [R37-AI14107, RO1-GM061855]; John Stewart Endowed Chair in Peptide
Chemistry; University of Colorado Cancer Center Support Grant [NIH
P30-CA046934]
FX This work was supported in part by NIH grant R37-AI14107 (to RKH) and
NIH grant RO1-GM061855 and the John Stewart Endowed Chair in Peptide
Chemistry (to RSH). Operation of the NMR spectrometers was supported by
the Program in Structural Biology and Biophysics and the University of
Colorado Cancer Center Support Grant (NIH P30-CA046934). No other grants
contributed to support of this work. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 50
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U1 1
U2 30
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2012
VL 7
IS 4
AR e34591
DI 10.1371/journal.pone.0034591
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959UT
UT WOS:000305341600047
PM 22514641
ER
PT J
AU Dong, HT
Zhang, L
Zheng, KL
Yao, HG
Chen, J
Yu, FC
Yu, XX
Mao, BZ
Zhao, D
Yao, J
Li, DB
AF Dong, Hai-Tao
Zhang, Lu
Zheng, Kang-Le
Yao, Hai-Gen
Chen, Jack
Yu, Feng-Chi
Yu, Xiao-Xing
Mao, Bi-Zeng
Zhao, Dong
Yao, Jian
Li, De-Bao
TI A Gaijin-like miniature inverted repeat transposable element is
mobilized in rice during cell differentiation
SO BMC GENOMICS
LA English
DT Article
ID ARABIDOPSIS-THALIANA; LTR-RETROTRANSPOSONS; ANTHER CULTURE; DNA
TRANSPOSON; GENOME; MITES; EVOLUTION; FAMILY; REVEALS; GENES
AB Background: Miniature inverted repeat transposable element (MITE) is one type of transposable element (TE), which is largely found in eukaryotic genomes and involved in a wide variety of biological events. However, only few MITEs were proved to be currently active and their physiological function remains largely unknown.
Results: We found that the amplicon discrepancy of a gene locus LOC_Os01g0420 in different rice cultivar genomes was resulted from the existence of a member of Gaijin-like MITEs (mGing). This result indicated that mGing transposition was occurred at this gene locus. By using a modified transposon display (TD) analysis, the active transpositions of mGing were detected in rice Jiahua No. 1 genome under three conditions: in seedlings germinated from the seeds received a high dose gamma-ray irradiation, in plantlets regenerated from anther-derived calli and from scutellum-derived calli, and were confirmed by PCR validation and sequencing. Sequence analysis revealed that single nucleotide polymorphisms (SNPs) or short additional DNA sequences at transposition sites post mGing transposition. It suggested that sequence modification was possibly taken place during mGing transposition. Furthermore, cell re-differentiation experiment showed that active transpositions of both mGing and mPing (another well studied MITE) were identified only in regenerated plantlets.
Conclusions: It is for the first time that mGing active transposition was demonstrated under gamma-ray irradiation or in cell re-differentiation process in rice. This newly identified active MITE will provide a foundation for further analysis of the roles of MITEs in biological process.
C1 [Dong, Hai-Tao; Zhang, Lu; Yu, Xiao-Xing; Mao, Bi-Zeng; Zhao, Dong; Li, De-Bao] Zhejiang Univ, Coll Agr & Biotechnol, Inst Biotechnol, Hangzhou 310029, Zhejiang, Peoples R China.
[Zheng, Kang-Le] China Natl Rice Res Inst, Natl Ctr Rice Improvement, Hangzhou 310006, Zhejiang, Peoples R China.
[Yao, Hai-Gen; Yu, Feng-Chi; Yao, Jian] Jiaxing Acad Agr Sci, Jiaxing 314016, Peoples R China.
[Chen, Jack] NICHD, Unit Biocomputat, NIH, Bethesda, MD 20892 USA.
RP Li, DB (reprint author), Zhejiang Univ, Coll Agr & Biotechnol, Inst Biotechnol, Hangzhou 310029, Zhejiang, Peoples R China.
EM debl3@yahoo.com
FU National Natural Science Foundation of China [30871329]; Natural Science
Foundation of Zhejiang [Y307099]
FX The authors would like to thank Dr. Lunquan Sun for his critical reading
and valuable suggestions for improvement of the manuscript and Dr.
Frederick Luk for his help and contribution in preparing the manuscript.
This work was supported in part by grants from the National Natural
Science Foundation of China grant 30871329 and Natural Science
Foundation of Zhejiang grant Y307099. The funding agencies played no
role in study design, in the collection, analysis and interpretation of
data; in the writing of the manuscript; or in the decision to submit the
manuscript for publication.
NR 32
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U1 0
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD APR 13
PY 2012
VL 13
AR 135
DI 10.1186/1471-2164-13-135
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 943WK
UT WOS:000304156200001
PM 22500940
ER
PT J
AU Zeng, HK
Shen, EH
Hohmann, JG
Oh, SW
Bernard, A
Royall, JJ
Glattfelder, KJ
Sunkin, SM
Morris, JA
Guillozet-Bongaarts, AL
Smith, KA
Ebbert, AJ
Swanson, B
Kuan, L
Page, DT
Overly, CC
Lein, ES
Hawrylycz, MJ
Hof, PR
Hyde, TM
Kleinman, JE
Jones, AR
AF Zeng, Hongkui
Shen, Elaine H.
Hohmann, John G.
Oh, Seung Wook
Bernard, Amy
Royall, Joshua J.
Glattfelder, Katie J.
Sunkin, Susan M.
Morris, John A.
Guillozet-Bongaarts, Angela L.
Smith, Kimberly A.
Ebbert, Amanda J.
Swanson, Beryl
Kuan, Leonard
Page, Damon T.
Overly, Caroline C.
Lein, Ed S.
Hawrylycz, Michael J.
Hof, Patrick R.
Hyde, Thomas M.
Kleinman, Joel E.
Jones, Allan R.
TI Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex
Reveals Species-Specific Molecular Signatures
SO CELL
LA English
DT Article
ID HUMAN BRAIN EVOLUTION; CEREBRAL-CORTEX; HUMAN GENOME; HOMO-SAPIENS; COPY
NUMBER; MOUSE-BRAIN; EXPRESSION; NEURONS; TRANSCRIPTOME; INSIGHTS
AB Although there have been major advances in elucidating the functional biology of the human brain, relatively little is known of its cellular and molecular organization. Here we report a large-scale characterization of the expression of similar to 1,000 genes important for neural functions by in situ hybridization at a cellular resolution in visual and temporal cortices of adult human brains. These data reveal diverse gene expression patterns and remarkable conservation of each individual gene's expression among individuals (95%), cortical areas (84%), and between human and mouse (79%). A small but substantial number of genes (21%) exhibited species-differential expression. Distinct molecular signatures, comprised of genes both common between species and unique to each, were identified for each major cortical cell type. The data suggest that gene expression profile changes may contribute to differential cortical function across species, and in particular, a shift from corticosubcortical to more predominant corticocortical communications in the human brain.
C1 [Zeng, Hongkui; Shen, Elaine H.; Hohmann, John G.; Oh, Seung Wook; Bernard, Amy; Royall, Joshua J.; Glattfelder, Katie J.; Sunkin, Susan M.; Morris, John A.; Guillozet-Bongaarts, Angela L.; Smith, Kimberly A.; Ebbert, Amanda J.; Swanson, Beryl; Kuan, Leonard; Page, Damon T.; Overly, Caroline C.; Lein, Ed S.; Hawrylycz, Michael J.; Jones, Allan R.] Allen Inst Brain Sci, Seattle, WA 98103 USA.
[Hof, Patrick R.] Mt Sinai Sch Med, Fishberg Dept Neurosci, New York, NY 10029 USA.
[Hof, Patrick R.] Mt Sinai Sch Med, Friedman Brain Inst, New York, NY 10029 USA.
[Hyde, Thomas M.] Lieber Inst Brain Dev, Baltimore, MD 21205 USA.
[Hyde, Thomas M.; Kleinman, Joel E.] NIMH, Sect Neuropathol, Clin Brain Disorders Branch,NIH, Genes Cognit & Psychosis Program,Intramural Res P, Bethesda, MD 20892 USA.
RP Zeng, HK (reprint author), Allen Inst Brain Sci, Seattle, WA 98103 USA.
EM hongkuiz@alleninstitute.org; allanj@alleninstitute.org
FU Allen Institute for Brain Science; Allen Institute
FX We are grateful for the technical support and expertise of the Atlas
Production Team, led by Paul Wohnoutka, and the Information Technology
Team, led by Chinh Dang, at the Allen Institute, without which the work
would have not been accomplished. We thank Drs. Deborah Mash and
Margaret Basile of the University of Miami Brain Endowment Bank for
providing tissue. This work was funded by the Allen Institute for Brain
Science. The authors wish to thank the Allen Institute founders, Paul G.
Allen and Jody Allen, for their vision, encouragement, and support.
NR 46
TC 79
Z9 79
U1 1
U2 24
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD APR 13
PY 2012
VL 149
IS 2
BP 483
EP 496
DI 10.1016/j.cell.2012.02.052
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 926BF
UT WOS:000302805600024
PM 22500809
ER
PT J
AU Murai, J
Huang, SYN
Das, BB
Dexheimer, TS
Takeda, S
Pommier, Y
AF Murai, Junko
Huang, Shar-yin N.
Das, Benu Brata
Dexheimer, Thomas S.
Takeda, Shunichi
Pommier, Yves
TI Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by
Topoisomerases I and II and Base Alkylation in Vertebrate Cells
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID DOUBLE-STRAND BREAKS; CLEAVAGE COMPLEXES; SPINOCEREBELLAR ATAXIA;
COVALENT COMPLEXES; REPLICATION FORKS; AXONAL NEUROPATHY; ANTITUMOR
DRUGS; TRANSCRIPTION; ENZYME; PHOSPHORYLATION
AB Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes (Top1cc) by hydrolyzing their 3'-phosphotyrosyl DNA bonds and repairs bleomycin-induced DNA damage by hydrolyzing 3'-phosphoglycolates. Yeast Tdp1 has also been implicated in the repair of topoisomerase II-DNA cleavage complexes (Top2cc). To determine whether vertebrate Tdp1 is involved in the repair of various DNA end-blocking lesions, we generated Tdp1 knock-out cells in chicken DT40 cells (Tdp1(-/-)) and Tdp1-complemented DT40 cells with human TDP1. We found that Tdp1(-/-) cells were not only hypersensitive to camptothecin and bleomycin but also to etoposide, methyl methanesulfonate (MMS), H2O2, and ionizing radiation. We also show they were deficient in mitochondrial Tdp1 activity. In biochemical assays, recombinant human TDP1 was found to process 5'-phosphotyrosyl DNA ends when they mimic the 5'-overhangs of Top2cc. Tdp1 also processes 3'-deoxyribose phosphates generated from hydrolysis of abasic sites, which is consistent with the hypersensitivity of Tdp1(-/-) cells to MMS and H2O2. Because recent studies established that CtIP together with BRCA1 also repairs topoisomerase-mediated DNA damage, we generated dual Tdp1-CtIP-deficient DT40 cells. Our results show that Tdp1 and CtIP act in parallel pathways for the repair of Top1cc and MMS-induced lesions but are epistatic for Top2cc. Together, our findings reveal a broad involvement of Tdp1 in DNA repair and clarify the role of human TDP1 in the repair of Top2-induced DNA damage.
C1 [Huang, Shar-yin N.; Das, Benu Brata; Dexheimer, Thomas S.; Pommier, Yves] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Murai, Junko; Takeda, Shunichi] Kyoto Univ, Dept Radiat Genet, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan.
RP Pommier, Y (reprint author), NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
EM pommier@nih.gov
FU National Institutes of Health through NCI Center for Cancer Research;
Japan Society for the Promotion of Science
FX This work was supported, in whole or in part, by the National Institutes
of Health through the Intramural Program of the NCI Center for Cancer
Research.; Recipient of a fellowship from the Japan Society for the
Promotion of Science.
NR 67
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U1 0
U2 21
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 13
PY 2012
VL 287
IS 16
BP 12848
EP 12857
DI 10.1074/jbc.M111.333963
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 927JO
UT WOS:000302903700024
PM 22375014
ER
PT J
AU Geczy, T
Peach, ML
El Kazzouli, S
Sigano, DM
Kang, JH
Valle, CJ
Selezneva, J
Woo, W
Kedei, N
Lewin, NE
Garfield, SH
Lim, L
Mannan, P
Marquez, VE
Blumberg, PM
AF Geczy, Tamas
Peach, Megan L.
El Kazzouli, Said
Sigano, Dina M.
Kang, Ji-Hye
Valle, Christopher J.
Selezneva, Julia
Woo, Wonhee
Kedei, Noemi
Lewin, Nancy E.
Garfield, Susan H.
Lim, Langston
Mannan, Poonam
Marquez, Victor E.
Blumberg, Peter M.
TI Molecular Basis for Failure of "Atypical" C1 Domain of Vav1 to Bind
Diacylglycerol/Phorbol Ester
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PROTEIN-KINASE-C; CONFORMATIONALLY CONSTRAINED ANALOGS;
DROSOPHILA-MELANOGASTER HOMOLOG; SIGNAL TRANSDUCER PROTEIN;
SITE-DIRECTED MUTAGENESIS; CYSTEINE-RICH DOMAINS; PHORBOL ESTER;
BIOLOGICAL-ACTIVITIES; HUMAN MALIGNANCIES; CRYSTAL-STRUCTURE
AB C1 domains, the recognition motif of the second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-responsive) or atypical (not ligand-responsive). The C1 domain of Vav1, a guanine nucleotide exchange factor, plays a critical role in regulation of Vav activity through stabilization of the Dbl homology domain, which is responsible for exchange activity of Vav. Although the C1 domain of Vav1 is classified as atypical, it retains a binding pocket geometry homologous to that of the typical C1 domains of PKCs. This study clarifies the basis for its failure to bind ligands. Substituting Vav1-specific residues into the C1b domain of PKC delta, we identified five crucial residues (Glu(9), Glu(10), Thr(11), Thr(24), and Tyr(26)) along the rim of the binding cleft that weaken binding potency in a cumulative fashion. Reciprocally, replacing these incompatible residues in the Vav1 C1 domain with the corresponding residues from PKC delta C1b (delta C1b) conferred high potency for phorbol ester binding. Computer modeling predicts that these unique residues in Vav1 increase the hydrophilicity of the rim of the binding pocket, impairing membrane association and thereby preventing formation of the ternary C1-ligand-membrane binding complex. The initial design of diacylglycerol-lactones to exploit these Vav1 unique residues showed enhanced selectivity for C1 domains incorporating these residues, suggesting a strategy for the development of ligands targeting Vav1.
C1 [Geczy, Tamas; Valle, Christopher J.; Selezneva, Julia; Woo, Wonhee; Kedei, Noemi; Lewin, Nancy E.; Blumberg, Peter M.] NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Garfield, Susan H.; Lim, Langston; Mannan, Poonam] NCI, Expt Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[El Kazzouli, Said; Sigano, Dina M.; Kang, Ji-Hye; Marquez, Victor E.] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Ft Detrick, MD 21702 USA.
[Peach, Megan L.] NCI, Basic Res Program, SAIC Frederick, NIH, Ft Detrick, MD 21702 USA.
RP Blumberg, PM (reprint author), NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bldg 37,Rm 4048,37 Convent Dr,MSC 4255, Bethesda, MD 20892 USA.
EM blumberp@dc37a.nci.nih.gov
RI Sigano, Dina/M-6144-2014
OI Sigano, Dina/0000-0001-7489-9555
FU National Institutes of Health from NCI [Z1A BC 005270]
FX This work was supported, in whole or in part, by National Institutes of
Health Project Z1A BC 005270 from the Intramural Research Program, NCI.
NR 69
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Z9 11
U1 0
U2 10
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 13
PY 2012
VL 287
IS 16
BP 13137
EP 13158
DI 10.1074/jbc.M111.320010
PG 22
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 927JO
UT WOS:000302903700053
PM 22351766
ER
PT J
AU Joe, MK
Kee, C
Tomarev, SI
AF Joe, Myung Kuk
Kee, Changwon
Tomarev, Stanislav I.
TI Myocilin Interacts with Syntrophins and Is Member of
Dystrophin-associated Protein Complex
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID OPEN-ANGLE GLAUCOMA; TRABECULAR MESHWORK CELLS; SKELETAL-MUSCLE ATROPHY;
GLUCOCORTICOID-INDUCED MYOPATHY; GLYCOPROTEIN COMPLEX; TRANSCRIPTION
FACTORS; GENE-EXPRESSION; TRANSGENIC MICE; MUTATED MOUSE; NON-SECRETION
AB Genetic studies have linked myocilin to open angle glaucoma, but the functions of the protein in the eye and other tissues have remained elusive. The purpose of this investigation was to elucidate myocilin function(s). We identified alpha 1-syntrophin, a component of the dystrophin-associated protein complex (DAPC), as a myocilin-binding candidate. Myocilin interacted with alpha 1-syntrophin via its N-terminal domain and co-immunoprecipitated with alpha 1-syntrophin from C2C12 myotubes and mouse skeletal muscle. Expression of 15-fold higher levels of myocilin in the muscles of transgenic mice led to the elevated association of alpha 1-syntrophin, neuronal nitric-oxide synthase, and alpha-dystroglycan with DAPC, which increased the binding of laminin to alpha-dystroglycan and Akt signaling. Phosphorylation of Akt and Forkhead box O-class 3, key regulators of muscle size, was increased more than 3-fold, whereas the expression of muscle-specific RING finger protein-1 and atrogin-1, muscle atrophy markers, was decreased by 79 and 88%, respectively, in the muscles of transgenic mice. Consequently, the average size of muscle fibers of the transgenic mice was increased by 36% relative to controls. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of DAPC.
C1 [Joe, Myung Kuk; Tomarev, Stanislav I.] NEI, Retinal Gangl Cell Biol Sect, Lab Retinal Cell & Mol Biol, NIH, Bethesda, MD 20892 USA.
[Kee, Changwon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Ophthalmol, Seoul 135710, South Korea.
RP Tomarev, SI (reprint author), NEI, Retinal Gangl Cell Biol Sect, Lab Retinal Cell & Mol Biol, NIH, Bldg 6,Rm 212A,6 Ctr Dr, Bethesda, MD 20892 USA.
EM tomarevs@nei.nih.gov
FU National Institutes of Health, NEI
FX This work was supported, in whole or in part, by the National Institutes
of Health, NEI, Intramural Research Program.
NR 66
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U1 0
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 13
PY 2012
VL 287
IS 16
BP 13216
EP 13227
DI 10.1074/jbc.M111.224063
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 927JO
UT WOS:000302903700059
PM 22371502
ER
PT J
AU Walmacq, C
Cheung, ACM
Kireeva, ML
Lubkowska, L
Ye, CC
Gotte, D
Strathern, JN
Care, T
Cramer, P
Kashlev, M
AF Walmacq, Celine
Cheung, Alan C. M.
Kireeva, Maria L.
Lubkowska, Lucyna
Ye, Chengcheng
Gotte, Deanna
Strathern, Jeffrey N.
Care, Thomas
Cramer, Patrick
Kashlev, Mikhail
TI Mechanism of Translesion Transcription by RNA Polymerase II and Its Role
in Cellular Resistance to DNA Damage
SO MOLECULAR CELL
LA English
DT Article
ID CYCLOBUTANE PYRIMIDINE DIMER; STRUCTURAL BASIS; EXCISION-REPAIR; THYMINE
DIMER; TRIGGER LOOP; DHFR GENE; A-RULE; ELONGATION; FIDELITY; COMPLEX
AB UV-induced cyclobutane pyrimidine dimers (CPDs) in the template DNA strand stall transcription elongation by RNA polymerase II (Pol II). If the nucleotide excision repair machinery does not promptly remove the CPDs, stalled Pol II creates a roadblock for DNA replication and subsequent rounds of transcription. Here we present evidence that Pol II has an intrinsic capacity for translesion synthesis (TLS) that enables bypass of the CPD with or without repair. Trans lesion synthesis depends on the trigger loop and bridge helix, the two flexible regions of the Pol II subunit Rpb1 that participate in substrate binding, catalysis, and translocation. Substitutions in Rpb1 that promote lesion bypass in vitro increase UV resistance in vivo, and substitutions that inhibit lesion bypass decrease cell survival after UV irradiation. Thus, translesion transcription becomes essential for cell survival upon accumulation of the unrepaired CPD lesions in genomic DNA.
C1 [Walmacq, Celine; Kireeva, Maria L.; Lubkowska, Lucyna; Ye, Chengcheng; Gotte, Deanna; Strathern, Jeffrey N.; Kashlev, Mikhail] NCI, Ctr Canc Res, Frederick, MD 21702 USA.
[Cheung, Alan C. M.; Cramer, Patrick] Univ Munich, Gene Ctr, D-81377 Munich, Germany.
[Cheung, Alan C. M.; Cramer, Patrick] Univ Munich, Dept Biochem, Ctr Integrated Prot Sci CIPSM, D-81377 Munich, Germany.
[Care, Thomas] Univ Munich, Dept Chem, Ctr Integrated Prot Sci CIPSM, D-81377 Munich, Germany.
RP Kashlev, M (reprint author), NCI, Ctr Canc Res, Frederick, MD 21702 USA.
EM mkashlev@mail.ncifcrf.gov
OI Carell, Thomas/0000-0001-7898-2831
FU Deutsche Forschungsgemeinschaft [SFB646, TR5, FOR1068]; NIM; Bioimaging
Network BIN; Jung-Stiftung
FX We thank Brenda Schafer for technical help and Alison Rattray and Donald
Court for helpful discussion and for critical reading of the manuscript.
This research was supported by the Intramural Research Program of the
National Institutes of Health, National Cancer Institute. The contents
of this publication do not necessarily reveal the views of the policy of
the Department of Health and Human Services, nor does mention of trade
names, commercial products, or organizations imply endorsement by the
U.S. government. Part of this work was performed at the Swiss Light
Source at the Paul Scherrer Institut, Villigen, Switzerland. P.C. was
supported by the Deutsche Forschungsgemeinschaft, SFB646, TR5, FOR1068,
NIM, Bioimaging Network BIN, and the Jung-Stiftung.
NR 39
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U1 3
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD APR 13
PY 2012
VL 46
IS 1
BP 18
EP 29
DI 10.1016/j.molcel.2012.02.006
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 926NL
UT WOS:000302838000005
PM 22405652
ER
PT J
AU Li, MM
He, YL
Dubois, W
Wu, XL
Shi, JX
Huang, J
AF Li, Mangmang
He, Yunlong
Dubois, Wendy
Wu, Xiaolin
Shi, Jianxin
Huang, Jing
TI Distinct Regulatory Mechanisms and Functions for p53-Activated and
p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
SO MOLECULAR CELL
LA English
DT Article
ID WILD-TYPE P53; TRANSCRIPTIONAL REPRESSION; PLURIPOTENT; NETWORK; GENOME;
EXPRESSION; PATHWAY; STATE; METHYLATION; SIGNATURES
AB p53 is critical in regulating the differentiation of ES and induced pluripotent stem (iPS) cells. Here, we report a whole-genome study of p53-mediated DNA damage signaling in mouse ES cells. Systems analyses reveal that binding of p53 at the promoter region significantly correlates with gene activation but not with repression. Unexpectedly, we identify a regulatory mode for p53-mediated repression through interfering with distal enhancer activity. Importantly, many ES cell-enriched core transcription factors are p53-repressed genes. Further analyses demonstrate that p53-repressed genes are functionally associated with ES/iPS cell status while p53-activated genes are linked to differentiation. p53-activated genes and -repressed genes also display distinguishable features of expression levels and epigenetic markers. Upon DNA damage, p53 regulates the self-renewal and pluripotency of ES cells. Together, these results support a model where, in response to DNA damage, p53 affects the status of ES cells through activating differentiation-associated genes and repressing ES cell-enriched genes.
C1 [Li, Mangmang; He, Yunlong; Dubois, Wendy; Huang, Jing] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA.
[Wu, Xiaolin] NCI, Lab Mol Technol, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21702 USA.
[Shi, Jianxin] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
RP Huang, J (reprint author), NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA.
EM huangj3@mail.nih.gov
RI Huang, Jing/A-2566-2009; LI, MANGMANG/J-1683-2015; He,
Yunlong/D-1278-2017
OI Huang, Jing/0000-0002-7163-5156;
FU Office of Science and Technology Partnerships at the Center for Cancer
Research (CCR); National Cancer Institute (NCI) at the National
Institutes of Health (NIH); NCI; National Cancer Institute, National
Institutes of Health [HHSN261200800001E]
FX We thank Glenn Merlino, Tom Misteli, Nan Roche, and Li Guo for
critically reading the manuscript and for their comments. J.H.'s
laboratory was funded by the intramural research program and partially
by the Office of Science and Technology Partnerships at the Center for
Cancer Research (CCR), the National Cancer Institute (NCI) at the
National Institutes of Health (NIH), and the NCI Director's Innovation
Award (to J.S. and J.H.). Microarray study has been funded in whole or
in part with federal funds from the National Cancer Institute, National
Institutes of Health, under Contract No. HHSN261200800001E. The
computational analyses utilized the high-performance computational
capabilities of the Helix Systems at NIH (http://helix.nih.gov).
NR 42
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U1 3
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD APR 13
PY 2012
VL 46
IS 1
BP 30
EP 42
DI 10.1016/j.molcel.2012.01.020
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 926NL
UT WOS:000302838000006
PM 22387025
ER
PT J
AU De Muyt, A
Jessop, L
Kolar, E
Sourirajan, A
Chen, JH
Dayani, Y
Lichten, M
AF De Muyt, Arnaud
Jessop, Lea
Kolar, Elizabeth
Sourirajan, Anuradha
Chen, Jianhong
Dayani, Yaron
Lichten, Michael
TI BLM Helicase Ortholog Sgs1 Is a Central Regulator of Meiotic
Recombination Intermediate Metabolism
SO MOLECULAR CELL
LA English
DT Article
ID DOUBLE-STRAND-BREAK; DOUBLE HOLLIDAY JUNCTIONS; BLOOMS-SYNDROME
HELICASE; SACCHAROMYCES-CEREVISIAE; CROSSING-OVER; BUDDING YEAST;
HOMOLOGOUS RECOMBINATION; MUS81/MMS4 ENDONUCLEASE; JOINT MOLECULES; RECQ
HELICASE
AB The BLM helicase has been shown to maintain genome stability by preventing accumulation of aberrant recombination intermediates. We show here that the Saccharomyces cerevisiae BLM ortholog, Sgs1, plays an integral role in normal meiotic recombination, beyond its documented activity limiting aberrant recombination intermediates. In wild-type meiosis, temporally and mechanistically distinct pathways produce crossover and noncrossover recombinants. Crossovers form late in meiosis I prophase, by polo kinase-triggered resolution of Holliday junction (HJ) intermediates. Noncrossovers form earlier, via processes that do not involve stable HJ intermediates. In contrast, sgs1 mutants abolish early noncrossover formation. Instead, both non-crossovers and crossovers form by late HJ intermediate resolution, using an alternate pathway requiring the overlapping activities of Mus81-Mms4, Yen1, and Slx1-Slx4, nucleases with minor roles in wildtype meiosis. We conclude that Sgs1 is a primary regulator of recombination pathway choice during meiosis and suggest a similar function in the mitotic cell cycle.
C1 [De Muyt, Arnaud; Jessop, Lea; Kolar, Elizabeth; Sourirajan, Anuradha; Chen, Jianhong; Dayani, Yaron; Lichten, Michael] NCI, Lab Biochem & Mol Biol, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Lichten, M (reprint author), NCI, Lab Biochem & Mol Biol, Ctr Canc Res, Bethesda, MD 20892 USA.
EM lichten@helix.nih.gov
RI Lichten, Michael/C-5795-2013
OI Lichten, Michael/0000-0001-9707-2956
FU National Institutes of Health, through the Center for Cancer Research of
the National Cancer Institute
FX We thank Neil Hunter for communicating unpublished data, and Valerie
Borde, Dhruba Chattoraj, Mathilde Grelon, Neil Hunter, Raphael Mercier,
Yikang Rong, and Denise Zickler for helpful discussions. This work was
supported by the Intramural Research Program of the National Institutes
of Health, through the Center for Cancer Research of the National Cancer
Institute.
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U2 23
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD APR 13
PY 2012
VL 46
IS 1
BP 43
EP 53
DI 10.1016/j.molcel.2012.02.020
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 926NL
UT WOS:000302838000007
PM 22500736
ER
PT J
AU Lee, IH
Kawai, Y
Fergusson, MM
Rovira, II
Bishop, AJR
Motoyama, N
Cao, L
Finkel, T
AF Lee, In Hye
Kawai, Yoshichika
Fergusson, Maria M.
Rovira, Ilsa I.
Bishop, Alexander J. R.
Motoyama, Noboru
Cao, Liu
Finkel, Toren
TI Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During
Metabolic Stress
SO SCIENCE
LA English
DT Article
ID DNA-DAMAGE RESPONSE; AUTOPHAGY; QUIESCENCE; APOPTOSIS; TUMORIGENESIS;
FIBROBLASTS; STARVATION; THERAPY; PATHWAY
AB Withdrawal of nutrients triggers an exit from the cell division cycle, the induction of autophagy, and eventually the activation of cell death pathways. The relation, if any, among these events is not well characterized. We found that starved mouse embryonic fibroblasts lacking the essential autophagy gene product Atg7 failed to undergo cell cycle arrest. Independent of its E1-like enzymatic activity, Atg7 could bind to the tumor suppressor p53 to regulate the transcription of the gene encoding the cell cycle inhibitor p21(CDKN1A). With prolonged metabolic stress, the absence of Atg7 resulted in augmented DNA damage with increased p53-dependent apoptosis. Inhibition of the DNA damage response by deletion of the protein kinase Chk2 partially rescued postnatal lethality in Atg7(-/-) mice. Thus, when nutrients are limited, Atg7 regulates p53-dependent cell cycle and cell death pathways.
C1 [Cao, Liu] China Med Univ, Key Lab Med Cell Biol, Shenyang 110001, Peoples R China.
[Lee, In Hye; Kawai, Yoshichika; Fergusson, Maria M.; Rovira, Ilsa I.; Finkel, Toren] NHLBI, Ctr Mol Med, Bethesda, MD 20892 USA.
[Bishop, Alexander J. R.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Motoyama, Noboru] Natl Ctr Geriatr & Gerontol, Res Inst, Dept Cognit Brain Sci, Aichi 4748511, Japan.
RP Cao, L (reprint author), China Med Univ, Key Lab Med Cell Biol, Shenyang 110001, Peoples R China.
EM caoliu@mail.cmu.edu; finkelt@nih.gov
FU National Natural Science Foundation of China [81130042, 31171323]; NIH;
Ellison Medical Foundation
FX We thank M. Komatsu for providing the Atg7+/- mice. Supported
by National Natural Science Foundation of China grants 81130042 and
31171323 (L.C.), NIH intramural funds, and a grant from the Ellison
Medical Foundation (T.F.).
NR 25
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U1 1
U2 47
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD APR 13
PY 2012
VL 336
IS 6078
BP 225
EP 228
DI 10.1126/science.1218395
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 924PN
UT WOS:000302703900049
PM 22499945
ER
PT J
AU Xue, YX
Luo, YX
Wu, P
Shi, HS
Xue, LF
Chen, C
Zhu, WL
Ding, ZB
Bao, YP
Shi, J
Epstein, DH
Shaham, Y
Lu, L
AF Xue, Yan-Xue
Luo, Yi-Xiao
Wu, Ping
Shi, Hai-Shui
Xue, Li-Fen
Chen, Chen
Zhu, Wei-Li
Ding, Zeng-Bo
Bao, Yan-ping
Shi, Jie
Epstein, David H.
Shaham, Yavin
Lu, Lin
TI A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and
Relapse
SO SCIENCE
LA English
DT Article
ID LONG-TERM-MEMORY; COCAINE-SEEKING; DISRUPTING RECONSOLIDATION;
BASOLATERAL AMYGDALA; PROTEIN-SYNTHESIS; FEAR MEMORIES; CUE-EXPOSURE;
PKM-ZETA; MECHANISMS; ADDICTION
AB Drug use and relapse involve learned associations between drug-associated environmental cues and drug effects. Extinction procedures in the clinic can suppress conditioned responses to drug cues, but the extinguished responses typically reemerge after exposure to the drug itself (reinstatement), the drug-associated environment (renewal), or the passage of time (spontaneous recovery). We describe a memory retrieval-extinction procedure that decreases conditioned drug effects and drug seeking in rat models of relapse, and drug craving in abstinent heroin addicts. In rats, daily retrieval of drug-associated memories 10 minutes or 1 hour but not 6 hours before extinction sessions attenuated drug-induced reinstatement, spontaneous recovery, and renewal of conditioned drug effects and drug seeking. In heroin addicts, retrieval of drug-associated memories 10 minutes before extinction sessions attenuated cue-induced heroin craving 1, 30, and 180 days later. The memory retrieval-extinction procedure is a promising nonpharmacological method for decreasing drug craving and relapse during abstinence.
C1 [Xue, Yan-Xue; Luo, Yi-Xiao; Wu, Ping; Shi, Hai-Shui; Xue, Li-Fen; Chen, Chen; Zhu, Wei-Li; Ding, Zeng-Bo; Bao, Yan-ping; Shi, Jie; Lu, Lin] Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China.
[Shi, Hai-Shui] Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China.
[Epstein, David H.; Shaham, Yavin] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
RP Lu, L (reprint author), Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China.
EM linlu@bjmu.edu.cn
RI shaham, yavin/G-1306-2014
FU National Basic Research Program of China [2009CB522000, 2011CB707800];
Natural Science Foundation of China [91132716, 31070958]; National
Institute on Drug Abuse
FX This work was supported in part by the National Basic Research Program
of China (No 2009CB522000 and 2011CB707800) and the Natural Science
Foundation of China (No 91132716 and 31070958). The preparation of the
manuscript was also supported in part by the Intramural Research Program
of the National Institute on Drug Abuse. The authors declare that they
do not have any conflicts of interest related to the data presented in
this manuscript.
NR 46
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U1 11
U2 119
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD APR 13
PY 2012
VL 336
IS 6078
BP 241
EP 245
DI 10.1126/science.1215070
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 924PN
UT WOS:000302703900053
PM 22499948
ER
PT J
AU Chen, L
Kasai, T
Li, YG
Sugii, Y
Jin, GL
Okada, M
Vaidyanath, A
Mizutani, A
Satoh, A
Kudoh, T
Hendrix, MJC
Salomon, DS
Fu, L
Seno, M
AF Chen, Ling
Kasai, Tomonari
Li, Yueguang
Sugii, Yuh
Jin, Guoliang
Okada, Masashi
Vaidyanath, Arun
Mizutani, Akifumi
Satoh, Ayano
Kudoh, Takayuki
Hendrix, Mary J. C.
Salomon, David S.
Fu, Li
Seno, Masaharu
TI A Model of Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem
Cells
SO PLOS ONE
LA English
DT Article
ID MAMMARY MICROENVIRONMENT; TUMOR-CELLS; TUMORIGENIC PHENOTYPE; COPY
NUMBER; DIFFERENTIATION; SUPPRESSES; GENERATION; EXOSOMES
AB Cancer stem cells (CSCs) are capable of continuous proliferation and self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. CSCs are considered derived from normal stem cells affected by the tumor microenvironment although the mechanism of development is not clear yet. In 2007, Yamanaka's group succeeded in generating Nanog mouse induced pluripotent stem (miPS) cells, in which green fluorescent protein (GFP) has been inserted into the 5'-untranslated region of the Nanog gene. Usually, iPS cells, just like embryonic stem cells, are considered to be induced into progenitor cells, which differentiate into various normal phenotypes depending on the normal niche. We hypothesized that CSCs could be derived from Nanog miPS cells in the conditioned culture medium of cancer cell lines, which is a mimic of carcinoma microenvironment. As a result, the Nanog miPS cells treated with the conditioned medium of mouse Lewis lung carcinoma acquired characteristics of CSCs, in that they formed spheroids expressing GFP in suspension culture, and had a high tumorigenicity in Balb/c nude mice exhibiting angiogenesis in vivo. In addition, these iPS-derived CSCs had a capacity of self-renewal and expressed the marker genes, Nanog, Rex1, Eras, Esg1 and Cripto, associated with stem cell properties and an undifferentiated state. Thus we concluded that a model of CSCs was originally developed from miPS cells and proposed the conditioned culture medium of cancer cell lines might perform as niche for producing CSCs. The model of CSCs and the procedure of their establishment will help study the genetic alterations and the secreted factors in the tumor microenvironment which convert miPS cells to CSCs. Furthermore, the identification of potentially bona fide markers of CSCs, which will help the development of novel anti-cancer therapies, might be possible though the CSC model.
C1 [Chen, Ling; Kasai, Tomonari; Sugii, Yuh; Jin, Guoliang; Okada, Masashi; Vaidyanath, Arun; Mizutani, Akifumi; Kudoh, Takayuki; Seno, Masaharu] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Med & Bioengn Sci, Okayama 7008530, Japan.
[Chen, Ling] Japan Soc Promot Sci, Tokyo, Japan.
[Chen, Ling] Tianjin Cent Hosp Gynecol Obstet, Dept Pathol, Tianjin, Peoples R China.
[Li, Yueguang] Tianjin 4th Ctr Hosp, Dept Gen Surg, Tianjin, Peoples R China.
[Satoh, Ayano] Okayama Univ, Multidisciplinary Div, Okayama 7008530, Japan.
[Hendrix, Mary J. C.] Northwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA.
[Salomon, David S.] NCI, Lab Mammary Biol & Tumorigenesis, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Fu, Li] Tianjin Med Univ, State Key Lab Breast Canc Res, Dept Breast Canc Pathol & Res Lab, Canc Hosp, Tianjin, Peoples R China.
RP Chen, L (reprint author), Okayama Univ, Grad Sch Nat Sci & Technol, Dept Med & Bioengn Sci, Okayama 7008530, Japan.
EM fulijyb@hotmail.com; mseno@cc.okayama-u.ac.jp
RI SENO, Masaharu /B-2092-2011;
OI SENO, Masaharu /0000-0001-8547-6259; SATOH, Ayano/0000-0003-3736-1283
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
[21300179]; National Natural Science Foundation of China (Key Program)
[30930038]
FX This work was supported by Grant-in-Aid for Scientific Research (B) from
the Ministry of Education, Culture, Sports, Science and Technology of
Japan (No. 21300179,
http://www.waseda.jp/rps/en/manual/kakenhi_honbun.html), and by National
Natural Science Foundation of China (Key Program, Grant No. 30930038,
http://www.nsfc.gov.cn/e_nsfc/desktop/zn/0101.htm). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 40
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U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 12
PY 2012
VL 7
IS 4
AR e33544
DI 10.1371/journal.pone.0033544
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959TZ
UT WOS:000305338600009
PM 22511923
ER
PT J
AU Decker, BK
Perez, F
Hujer, AM
Hujer, KM
Hall, GS
Jacobs, MR
Gebreyes, WA
Zoll, ST
Massire, C
Eshoo, MW
Ecker, DJ
Rather, PN
Bonomo, RA
AF Decker, Brooke K.
Perez, Federico
Hujer, Andrea M.
Hujer, Kristine M.
Hall, Geraldine S.
Jacobs, Michael R.
Gebreyes, Wondwossen A.
Zoll, Scott T.
Massire, Christian
Eshoo, Mark W.
Ecker, David J.
Rather, Philip N.
Bonomo, Robert A.
TI Longitudinal Analysis of the Temporal Evolution of Acinetobacter
baumannii Strains in Ohio, USA, by Using Rapid Automated Typing Methods
SO PLOS ONE
LA English
DT Article
ID ANTIBIOTIC-RESISTANCE; MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY;
OUTBREAK; PCR; REPRODUCIBILITY; DISSEMINATION; EMERGENCE; INFECTION;
MILITARY
AB Genotyping methods are essential to understand the transmission dynamics of Acinetobacter baumannii. We examined the representative genotypes of A. baumannii at different time periods in select locations in Ohio, using two rapid automated typing methods: PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), a form of multi-locus sequence typing (MLST), and repetitive-sequence-based-PCR (rep-PCR). Our analysis included 122 isolates from 4 referral hospital systems, in 2 urban areas of Ohio. These isolates were associated with outbreaks at 3 different time periods (1996, 2000 and 2005-2007). Type assignments of PCR/ESI-MS and rep-PCR were compared to each other and to worldwide (WW) clone types. The discriminatory power of each method was determined using the Simpson's index of diversity (DI). We observed that PCR/ESI-MS sequence type (ST) 14, corresponding to WW clone 3, predominated in 1996, whereas ST 12 and 14 coexisted in the intermediate period (2000) and ST 10 and 12, belonging to WW clone 2, predominated more recently in 2007. The shift from WW clone 3 to WW clone 2 was accompanied by an increase in carbapenem resistance. The DI was approximately 0.74 for PCR/ESI-MS, 0.88 for rep-PCR and 0.90 for the combination of both typing methods. We conclude that combining rapid automated typing methods such as PCR/ESI-MS and rep-PCR serves to optimally characterize the regional molecular epidemiology of A. baumannii. Our data also sheds light on the changing sequence types in an 11 year period in Northeast Ohio.
C1 [Decker, Brooke K.; Perez, Federico; Hujer, Andrea M.; Hujer, Kristine M.; Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA.
[Perez, Federico; Hujer, Andrea M.; Hujer, Kristine M.; Bonomo, Robert A.] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Res Serv, Cleveland, OH USA.
[Hall, Geraldine S.] Cleveland Clin, Pathol & Lab Med Inst, Cleveland, OH 44106 USA.
[Jacobs, Michael R.] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA.
[Gebreyes, Wondwossen A.] Ohio State Univ, Coll Vet Med, Columbus, OH 43210 USA.
[Zoll, Scott T.; Massire, Christian; Eshoo, Mark W.; Ecker, David J.] Abbott Mol Inc, Ibis Biosci Inc, Carlsbad, CA USA.
[Rather, Philip N.] Vet Affairs Med Ctr, Res Serv, Decatur, GA 30033 USA.
[Rather, Philip N.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
[Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA.
[Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA.
RP Decker, BK (reprint author), NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM Robert.Bonomo@va.gov
OI Decker M.D., Brooke K/0000-0002-3404-9115
FU Steris Corporation; Veterans Affairs Merit Review Program; National
Institute of Allergy and Infectious Diseases at the National Institutes
of Health [RO1-AI072219-05]; Geriatric Research, Education and Clinical
Care Center VISN [10]; Research Career Scientist Award from the
Department of Veterans Affairs
FX Funding for this study was provided by the Steris Corporation to FP. RAB
is supported by the Veterans Affairs Merit Review Program, the National
Institute of Allergy and Infectious Diseases at the National Institutes
of Health (grants RO1-AI072219-05) and the Geriatric Research, Education
and Clinical Care Center VISN 10. PNR is supported by a Research Career
Scientist Award from the Department of Veterans Affairs. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 39
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U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 12
PY 2012
VL 7
IS 4
AR e33443
DI 10.1371/journal.pone.0033443
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959TZ
UT WOS:000305338600008
PM 22511922
ER
PT J
AU Kitahara, CM
Platz, EA
Ladenson, PW
Mondul, AM
Menke, A
de Gonzalez, AB
AF Kitahara, Cari M.
Platz, Elizabeth A.
Ladenson, Paul W.
Mondul, Alison M.
Menke, Andy
de Gonzalez, Amy Berrington
TI Body Fatness and Markers of Thyroid Function among US Men and Women
SO PLOS ONE
LA English
DT Article
ID RESTING ENERGY-EXPENDITURE; CORONARY-HEART-DISEASE; MASS INDEX; SERUM
TSH; SUBCLINICAL HYPOTHYROIDISM; OBESE WOMEN; WEIGHT-LOSS; FREE T4;
ABDOMINAL ADIPOSITY; EUTHYROID SUBJECTS
AB Background: We evaluated the association of central versus overall adiposity on levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT(3)), and free thyroxine (fT(4)) among euthyroid subjects taken from a cross-sectional, representative sample of the adult non-institutionalized U. S. population.
Methods: The National Health and Nutrition Examination Survey 2007-2008 included 1,623 men and 1,491 women who were 20 years and older, with no history of thyroid or liver disease, kidney failure, diabetes, or thyroid function-altering prescription medication use (based on self-report), and having TSH, fT(3), and fT(4) levels between 0.5-4.49 mIU/L, 2.5-3.9 pg/mL, and 0.6-1.6 ng/dL, respectively. Associations between body mass index (BMI) and waist circumference (measures of overall and central adiposity, respectively) and TSH, fT(3), and fT(4) levels were estimated using multivariable linear regression models stratified by sex and adjusted for age, race, smoking status, and alcohol intake.
Results: An increase in serum TSH levels was observed for every 1-quartile increase in BMI in euthyroid men (3.8% [95% CI 0.8%, 6.8%]) and euthyroid women (4.0% [95% CI 1.6%, 6.5%]). Similar, albeit slightly weaker, associations were observed with waist circumference. We also found increases in fT(3) levels with every 1-quartile increase in BMI (1.0% in men and 1.3% in women) and waist circumference (1.2% in men and 1.2% in women). No associations were observed with fT(4).
Conclusions: Our results provide support that BMI and waist circumference are positively associated with levels of serum TSH and f T-3 but not fT(4) among euthyroid adults. Longitudinal studies are needed to define the temporality of these associations and their potential health implications.
C1 [Kitahara, Cari M.; Platz, Elizabeth A.; Menke, Andy] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Kitahara, Cari M.; Mondul, Alison M.; de Gonzalez, Amy Berrington] NCI, NIH, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Ladenson, Paul W.] Johns Hopkins Med Inst, Dept Med, Div Endocrinol & Metab, Baltimore, MD 21205 USA.
RP Kitahara, CM (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
EM kitaharac@mail.nih.gov
RI Kitahara, Cari/R-8267-2016;
OI Mondul, Alison/0000-0002-8843-1416
FU Intramural Research Program of the National Cancer Institute, National
Institutes of Health
FX This work was supported by the Intramural Research Program of the
National Cancer Institute, National Institutes of Health. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 37
TC 37
Z9 37
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 12
PY 2012
VL 7
IS 4
AR e34979
DI 10.1371/journal.pone.0034979
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 959TZ
UT WOS:000305338600062
PM 22511976
ER
PT J
AU Gaiser, T
Geissinger, E
Schattenberg, T
Scharf, HP
Durken, M
Dinter, D
Rosenwald, A
Marx, A
AF Gaiser, Timo
Geissinger, Eva
Schattenberg, Torsten
Scharf, Hanns-Peter
Duerken, Matthias
Dinter, Dietmar
Rosenwald, Andreas
Marx, Alexander
TI Case report: a unique pediatric case of a primary CD8 expressing ALK-1
positive anaplastic large cell lymphoma of skeletal muscle
SO DIAGNOSTIC PATHOLOGY
LA English
DT Article
DE ALK-1; Anaplastic large cell lymphoma; CD30; Pediatric lymphoma
ID PSOAS MUSCLE; CLASSIFICATION; TRANSLOCATION; FEATURES; GENE
AB Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed a tumoral and diffuse polymorphic infiltration of the muscle by large lymphoid cells. Tumor cells displayed eccentric, lobulated "horse shoe" or "kidney-shape" nuclei. The cells showed immunohistochemical positivity for CD30, ALK-1, CD2, CD3, CD7, CD8, and Perforin. Fluorescence in situ hybridization analysis revealed a characteristic rearrangement of the ALK-1 gene in 2p23 leading to the diagnosis of ALK-1 positive ALCL. Chemotherapy according to the ALCL-99-NHL-BFM protocol was initiated and resulted in a complete remission after two cycles. This case illustrates the unusual presentation of a pediatric ALCL in soft tissue with a good response to chemotherapy.
C1 [Gaiser, Timo; Marx, Alexander] Univ Heidelberg, Med Fac Mannheim, Inst Pathol, D-68167 Mannheim, Germany.
[Schattenberg, Torsten; Scharf, Hanns-Peter] Univ Heidelberg, Med Fac Mannheim, Orthoped Clin, D-68167 Mannheim, Germany.
[Duerken, Matthias] Univ Heidelberg, Med Fac Mannheim, Dept Pediat, D-68167 Mannheim, Germany.
[Gaiser, Timo] NCI, Sect Canc Genom, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Geissinger, Eva; Rosenwald, Andreas] Univ Wurzburg, Inst Pathol, D-97080 Wurzburg, Germany.
RP Gaiser, T (reprint author), Univ Heidelberg, Med Fac Mannheim, Inst Pathol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM timo_gaiser@web.de
NR 19
TC 3
Z9 3
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1746-1596
J9 DIAGN PATHOL
JI Diagn. Pathol.
PD APR 12
PY 2012
VL 7
AR 38
DI 10.1186/1746-1596-7-38
PG 5
WC Pathology
SC Pathology
GA 949BS
UT WOS:000304551000001
PM 22497840
ER
EF