FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Cheng, SY
Zhang, YE
AF Cheng, Steven Y.
Zhang, Ying E.
TI Smurfs have "fused" into the asymmetric division of stem cells
SO PROTEIN & CELL
LA English
DT News Item
ID DROSOPHILA OVARY; HEDGEHOG
C1 [Cheng, Steven Y.] Nanjing Med Univ, Dept Dev Genet, Ctr Regenerat Med, Nanjing 210029, Jiangsu, Peoples R China.
[Zhang, Ying E.] NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA.
RP Cheng, SY (reprint author), Nanjing Med Univ, Dept Dev Genet, Ctr Regenerat Med, 140 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM sycheng@njmu.edu.cn
RI Zhang, Ying/G-3657-2015
OI Zhang, Ying/0000-0003-2753-7601
FU Intramural NIH HHS [ZIA BC011168-02]
NR 8
TC 1
Z9 1
U1 0
U2 3
PU HIGHER EDUCATION PRESS
PI BEIJING
PA SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA
SN 1674-800X
EI 1674-8018
J9 PROTEIN CELL
JI Protein Cell
PD JAN
PY 2011
VL 2
IS 1
BP 2
EP 4
DI 10.1007/s13238-011-1005-6
PG 3
WC Cell Biology
SC Cell Biology
GA 029TS
UT WOS:000310519400002
PM 21337003
ER
PT J
AU Kish, LB
Khatri, SP
Bezrukov, SM
Peper, F
Gingl, Z
Horvath, T
AF Kish, Laszlo B.
Khatri, Sunil P.
Bezrukov, Sergey M.
Peper, Ferdinand
Gingl, Zoltan
Horvath, Tamas
BE Deen, MJ
Chen, CH
TI Noise-based Information Processing Noise-based logic and computing: what
do we have so far?
SO 2011 21ST INTERNATIONAL CONFERENCE ON NOISE AND FLUCTUATIONS (ICNF)
LA English
DT Proceedings Paper
CT 21st International Conference on Noise and Fluctuations (ICNF)
CY JUN 12-16, 2011
CL Toronto, CANADA
SP McMaster Univ, Ryerson Univ, Univ Texas, IEEE Hamilton Sect, IEEE Elect Devices Soc, IEEE Toronto Sect, IEEE
DE Deterministic logic; multivalued logic; brain mimetics; noise as
information carrier
ID ENERGY; SUPERPOSITION; SPIKES; STATES
AB We briefly introduce noise-based logic. After describing the main motivations we outline classical, instantaneous (squeezed and non-squeezed), continuum, spike and random-telegraph-signal based schemes with applications such as circuits that emulate the brain functioning and string verification via a slow communication channel.
C1 [Kish, Laszlo B.; Khatri, Sunil P.] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
[Bezrukov, Sergey M.] NIH, NIHCD, Lab Phys & Struct Biol Program Phys Biol, Bethesda, MD 20892 USA.
[Peper, Ferdinand] Natl Inst Informat & Commun Technol, Kobe, Hyogo 6512492, Japan.
[Gingl, Zoltan] Univ Szeged, Dept Expt Phys, H-6720 Szeged, Hungary.
[Horvath, Tamas] Univ Bonn, Dept Comp Sci, Bonn, Germany.
[Horvath, Tamas] Schloss Birlinghoven, Fraunhofer IAIS, D-53754 St Augustin, Germany.
RP Kish, LB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
OI Gingl, Zoltan/0000-0001-6570-2685
NR 21
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4577-0192-4
PY 2011
BP 28
EP 33
PG 6
WC Engineering, Electrical & Electronic
SC Engineering
GA BCC62
UT WOS:000309730300006
ER
PT J
AU Wu, MC
Forbes, JG
Wang, K
AF Wu, Ming-Chya
Forbes, Jeffrey G.
Wang, Kuan
BE Deen, MJ
Chen, CH
TI Cross-correlation analysis to salt-bridge dynamics in force-induced
unfolding of titin kinase
SO 2011 21ST INTERNATIONAL CONFERENCE ON NOISE AND FLUCTUATIONS (ICNF)
LA English
DT Proceedings Paper
CT 21st International Conference on Noise and Fluctuations (ICNF)
CY JUN 12-16, 2011
CL Toronto, CANADA
SP McMaster Univ, Ryerson Univ, Univ Texas, IEEE Hamilton Sect, IEEE Elect Devices Soc, IEEE Toronto Sect, IEEE
ID TIME-SERIES
AB In this paper, a theoretical study on the salt-bridge dynamics of titin kinase is presented. We focus on the analysis of the spatial-temporal properties of the salt-bridge time series of titin kinase in force-induced unfolding simulated by steered molecular dynamics (SMD). Salt-bridge time series are defined from the SMD trajectories. Scaling analysis reveals two characteristics of the time series in short and long time scales, suggesting there is anti-persistent behavior in short-time scale less than 50 ps, while persistent behavior dominates in longtime scale larger than 100 ps. Using cross-correlation analysis, we study the dynamics of the salt-bridges. From analyzing the eigenvectors of the cross-correlation matrix constructed by the salt-bridge data, we classify salt-bridges into distinct groups. The knowledge of the grouping is useful in identifying force-relevant structural transitions.
C1 [Wu, Ming-Chya] Natl Cent Univ, Res Ctr Adapt Data Anal, Chungli 32001, Taiwan.
[Forbes, Jeffrey G.] NIH, NIAMSD, Bethesda, MD 20892 USA.
[Wang, Kuan] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan.
RP Wu, MC (reprint author), Natl Cent Univ, Res Ctr Adapt Data Anal, Chungli 32001, Taiwan.
EM mcwu@ncu.edu.tw
FU National Science Council of the Republic of China (Taiwan) [NSC
96-2112-M-008-021-MY3, 97-2627-B-008-004, 98-2627-B-008-004,
99-2627-B-008-002]; National Center for Theoretical Sciences at National
Taiwan University
FX This work was supported by the National Science Council of the Republic
of China (Taiwan) under Grant Nos. NSC 96-2112-M-008-021-MY3,
97-2627-B-008-004, 98-2627-B-008-004, and 99-2627-B-008-002, and
National Center for Theoretical Sciences at National Taiwan University.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4577-0192-4
PY 2011
BP 429
EP 432
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA BCC62
UT WOS:000309730300105
ER
PT J
AU Resnick, SM
Sojkova, J
AF Resnick, Susan M.
Sojkova, Jitka
TI Amyloid imaging and memory change for prediction of cognitive impairment
SO ALZHEIMERS RESEARCH & THERAPY
LA English
DT Review
ID PITTSBURGH COMPOUND-B; PRECLINICAL ALZHEIMERS-DISEASE; NONDEMENTED
INDIVIDUALS; PIB-PET; DEPOSITION; BETA; PATHOLOGY; DECLINE; RESERVE;
HYPERTROPHY
AB PET radiotracers for in vivo measurement of beta-amyloid (A beta) deposition throughout the brain are contributing to early detection of the neuropathology associated with Alzheimer's disease and enhancing prediction of individuals most likely to develop cognitive impairment and dementia. However, the fact that 30 to 50% of cognitively normal older adults have varying but detectable levels of A beta poses challenges and opportunities in using amyloid imaging in research and clinical applications. In this review, we summarize studies of the relationship between A beta burden and cognitive status in impaired and unimpaired individuals and the relationship between A beta burden and cognitive function. We conclude by operationalizing the way in which information on imaging-assessed A beta burden and cognitive performance can be used jointly to improve prediction of clinical outcomes, to enhance understanding of the role of A beta deposition in cognitive impairment, and to identify factors that promote cognitive resilience in the presence of A beta.
C1 [Resnick, Susan M.; Sojkova, Jitka] NIA, Lab Behav Neurosci, NIH Biomed Res Ctr, IRP, Baltimore, MD 21224 USA.
[Sojkova, Jitka] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD 21287 USA.
RP Resnick, SM (reprint author), NIA, Lab Behav Neurosci, NIH Biomed Res Ctr, IRP, 251 Bayview Blvd,Room 4B335, Baltimore, MD 21224 USA.
EM resnicks@grc.nia.nih.gov
FU Intramural Research Program of the NIH, National Institute on Aging;
[N01-AG-3-2124]
FX This research was supported by the Intramural Research Program of the
NIH, National Institute on Aging and N01-AG-3-2124.
NR 54
TC 14
Z9 14
U1 1
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-9193
J9 ALZHEIMERS RES THER
JI Alzheimers Res. Ther.
PY 2011
VL 3
IS 1
AR 3
DI 10.1186/alzrt62
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 024XJ
UT WOS:000310144700003
PM 21345176
ER
PT J
AU Shineman, DW
Basi, GS
Bizon, JL
Colton, CA
Greenberg, BD
Hollister, BA
Lincecum, J
Leblanc, GG
Lee, LH
Luo, F
Morgan, D
Morse, I
Refolo, LM
Riddell, DR
Scearce-Levie, K
Sweeney, P
Yrjanheikki, J
Fillit, HM
AF Shineman, Diana W.
Basi, Guriqbal S.
Bizon, Jennifer L.
Colton, Carol A.
Greenberg, Barry D.
Hollister, Beth A.
Lincecum, John
Leblanc, Gabrielle G.
Lee, Linda (Bobbi) H.
Luo, Feng
Morgan, Dave
Morse, Iva
Refolo, Lorenzo M.
Riddell, David R.
Scearce-Levie, Kimberly
Sweeney, Patrick
Yrjanheikki, Juha
Fillit, Howard M.
TI Accelerating drug discovery for Alzheimer's disease: best practices for
preclinical animal studies
SO ALZHEIMERS RESEARCH & THERAPY
LA English
DT Review
ID AMYLOID-PRECURSOR-PROTEIN; TRANSGENIC MICE; A-BETA; MOUSE MODEL;
COGNITIVE DECLINE; NEUROFIBRILLARY DEGENERATION; MEMORY IMPAIRMENT;
PLAQUE-FORMATION; MUTANT FORM; EARLY-ONSET
AB Animal models have contributed significantly to our understanding of the underlying biological mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been investigated and reported to mitigate pathological phenotypes or improve behavior in AD animal models or both. To date, however, very few of these findings have resulted in target validation in humans or successful translation to disease-modifying therapies. Challenges in translating preclinical studies to clinical trials include the inability of animal models to recapitulate the human disease, variations in breeding and colony maintenance, lack of standards in design, conduct and analysis of animal trials, and publication bias due to under-reporting of negative results in the scientific literature. The quality of animal model research on novel therapeutics can be improved by bringing the rigor of human clinical trials to animal studies. Research communities in several disease areas have developed recommendations for the conduct and reporting of preclinical studies in order to increase their validity, reproducibility, and predictive value. To address these issues in the AD community, the Alzheimer's Drug Discovery Foundation partnered with Charles River Discovery Services (Morrisville, NC, USA) and Cerebricon Ltd. (Kuopio, Finland) to convene an expert advisory panel of academic, industry, and government scientists to make recommendations on best practices for animal studies testing investigational AD therapies. The panel produced recommendations regarding the measurement, analysis, and reporting of relevant AD targets, the choice of animal model, quality control measures for breeding and colony maintenance, and preclinical animal study design. Major considerations to incorporate into preclinical study design include a priori hypotheses, pharmacokinetics-pharmacodynamics studies prior to proof-of-concept testing, biomarker measurements, sample size determination, and power analysis. The panel also recommended distinguishing between pilot 'exploratory' animal studies and more extensive 'therapeutic' studies to guide interpretation. Finally, the panel proposed infrastructure and resource development, such as the establishment of a public data repository in which both positive animal studies and negative ones could be reported. By promoting best practices, these recommendations can improve the methodological quality and predictive value of AD animal studies and make the translation to human clinical trials more efficient and reliable.
C1 [Shineman, Diana W.; Lee, Linda (Bobbi) H.; Fillit, Howard M.] Alzheimers Drug Discovery Fdn, New York, NY 10019 USA.
[Basi, Guriqbal S.] Elan Pharmaceut, San Francisco, CA 94080 USA.
[Bizon, Jennifer L.] Univ Florida, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA.
[Colton, Carol A.] Duke Univ, Med Ctr, Durham, NC 27710 USA.
[Greenberg, Barry D.] Univ Hlth Network, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada.
[Hollister, Beth A.] Charles River Discovery Serv, Morrisville, NC 27560 USA.
[Lincecum, John] ALS Therapy Dev Inst, Cambridge, MA 02142 USA.
[Leblanc, Gabrielle G.] Leblanc Neurosci Consulting, Berkeley, CA 94708 USA.
[Lee, Linda (Bobbi) H.] Columbia Univ, New York, NY 10032 USA.
[Luo, Feng] Abbott Neurosci, Abbott Pk, IL 60064 USA.
[Morgan, Dave] Univ S Florida, USF Hlth Byrd Alzheimer Inst, Tampa, FL 33613 USA.
[Morse, Iva] Charles River Labs Inc, Genetically Engineered Models & Serv, Wilmington, MA 01887 USA.
[Refolo, Lorenzo M.] NIA, Bethesda, MD 20892 USA.
[Riddell, David R.] Pfizer Neurosci Res Unit, Groton, CT 06340 USA.
[Scearce-Levie, Kimberly] Genentech Inc, San Francisco, CA 94080 USA.
[Sweeney, Patrick; Yrjanheikki, Juha] Cerebricon Ltd, Charles River Discovery Serv, Kuopio 70210, Finland.
RP Shineman, DW (reprint author), Alzheimers Drug Discovery Fdn, 57 West 57 St,Suite 904, New York, NY 10019 USA.
EM dshineman@alzdiscovery.org
RI Morgan, David/J-5989-2012
FU Charles River CHARTER (Commitment to Humane Animal Research Through
Excellence and Responsibility) program
FX We would like to convey our appreciation to key members of the
Alzheimer's Drug Discovery Foundation staff for their support in this
effort. In particular, we thank Filomena Machleder, Adam Liebling, and
Hannah Elkin. We are also grateful to the Charles River CHARTER
(Commitment to Humane Animal Research Through Excellence and
Responsibility) program for providing funding.
NR 67
TC 41
Z9 41
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-9193
J9 ALZHEIMERS RES THER
JI Alzheimers Res. Ther.
PY 2011
VL 3
IS 5
AR 28
DI 10.1186/alzrt90
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 024XW
UT WOS:000310146100003
PM 21943025
ER
PT J
AU Wang, PS
Aguilar-Gaxiola, S
Alonso, J
Lee, S
Schoenbaum, M
Ustun, TB
Kessler, RC
Bruffaerts, R
Borges, G
de Girolamo, G
Gureje, O
Haro, JM
Kostyuchenko, S
Masfety, VK
Levinson, D
Matschinger, H
Mneimneh, Z
Browne, MO
Ormel, J
Posada-Villa, J
Seedat, S
Tachimori, H
Tsang, A
AF Wang, Philip S.
Aguilar-Gaxiola, Sergio
Alonso, Jordi
Lee, Sing
Schoenbaum, Michael
Uestuen, T. Bedirhan
Kessler, Ronald C.
Bruffaerts, Ronny
Borges, Guilherme
de Girolamo, Giovanni
Gureje, Oye
Haro, Josep Maria
Kostyuchenko, Stanislav
Masfety, Viviane Kovess
Levinson, Daphna
Matschinger, Herbert
Mneimneh, Zeina
Browne, Mark Oakley
Ormel, Johan
Posada-Villa, Jose
Seedat, Soraya
Tachimori, Hisateru
Tsang, Adley
BE Regier, DA
Narrow, WE
Kuhl, EA
Kupfer, DJ
TI Assessing Mental Disorders and Service Use Across Countries The WHO
World Mental Health Survey Initiative
SO CONCEPTUAL EVOLUTION OF DSM-5
LA English
DT Article; Book Chapter
ID NATIONAL-COMORBIDITY-SURVEY; R PSYCHIATRIC-DISORDERS; REPLICATION NCS-R;
UNITED-STATES; 12-MONTH PREVALENCE; LIFETIME PREVALENCE;
GENERAL-POPULATION; SUICIDE ATTEMPTS; CATCHMENT-AREA; SOCIAL PHOBIA
C1 [Wang, Philip S.; Schoenbaum, Michael] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA.
[Aguilar-Gaxiola, Sergio] Univ Calif, Ctr Reducing Hlth Dispar, Davis Sch Med, Sacamento, CA USA.
[Lee, Sing] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
[Uestuen, T. Bedirhan] World Hlth Org, Geneva, Switzerland.
[Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Bruffaerts, Ronny] Katholieke Univ Leuven, Dept Neurosci, Louvain, Belgium.
[Borges, Guilherme] Natl Inst Psychiat Mexico, Dept Epidemiol Res, Div Epidemiol & Psychosocial Res, Mexico City, DF, Mexico.
[Borges, Guilherme] Metropolitan Autonomous Univ, Mexico City, DF, Mexico.
[Gureje, Oye] Univ Ibadan, Dept Psychiat, Univ Coll Hosp, Ibadan, Nigeria.
[Matschinger, Herbert] Univ Leipzig, Dept Psychiat & Psychotherapy, Leipzig, Germany.
[Mneimneh, Zeina] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA.
[Browne, Mark Oakley] Univ Tasmania, Discipline Psychiat, Sch Med, Hobart, Tas 7001, Australia.
[Ormel, Johan] Univ Med Ctr Groningen, Groningen, Netherlands.
[Seedat, Soraya] MRC, Unit Anxiety & Stress Disorders, Cape Town, South Africa.
[Tachimori, Hisateru] NIMH, Natl Ctr Neurol & Psychiat, Bethesda, MD 20892 USA.
[Tsang, Adley] Prince Wales Hosp, Hong Kong Mood Disorders Ctr, Hong Kong, Hong Kong, Peoples R China.
RP Wang, PS (reprint author), NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA.
RI Lee, Sing/O-2136-2015
NR 85
TC 0
Z9 0
U1 4
U2 8
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST NW, WASHINGTON, DC 20005 USA
BN 978-1-58562-388-4
PY 2011
BP 231
EP 266
PG 36
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA BCF30
UT WOS:000310051000012
ER
PT J
AU Pine, DS
Costello, EJ
Dahl, R
James, R
Leckman, JF
Leibenluft, E
Klein, RG
Rapoport, JL
Shaffer, D
Taylor, E
Zeanah, CH
AF Pine, Daniel S.
Costello, E. Jane
Dahl, Ron
James, Regina
Leckman, James F.
Leibenluft, Ellen
Klein, Rachel G.
Rapoport, Judith L.
Shaffer, David
Taylor, Eric
Zeanah, Charles H.
BE Regier, DA
Narrow, WE
Kuhl, EA
Kupfer, DJ
TI Increasing the Developmental Focus in DSM-5 Broad Issues and Specific
Potential Applications in Anxiety
SO CONCEPTUAL EVOLUTION OF DSM-5
LA English
DT Article; Book Chapter
ID OBSESSIVE-COMPULSIVE DISORDER; BEHAVIORAL-INHIBITION; SOCIAL-ANXIETY;
PANIC DISORDER; CHILDREN; ADOLESCENTS; RISK; DEPRESSION; CHILDHOOD; LIFE
C1 [Pine, Daniel S.; Leibenluft, Ellen] NIMH, Sect Bipolar Spectrum Disorders, Emot & Dev Branch, Mood & Anxiety Program, Bethesda, MD 20892 USA.
[Costello, E. Jane] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Dev Epidemiol, Durham, NC USA.
[Dahl, Ron] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA USA.
[James, Regina] NICHHD, Div Special Populat, Bethesda, MD 20892 USA.
[Leckman, James F.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA.
[Klein, Rachel G.] NYU, Ctr Child Study, New York, NY USA.
[Rapoport, Judith L.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[Shaffer, David] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Taylor, Eric] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
[Zeanah, Charles H.] Tulane Univ, Dept Psychiat, New Orleans, LA 70118 USA.
RP Pine, DS (reprint author), NIMH, Sect Bipolar Spectrum Disorders, Emot & Dev Branch, Mood & Anxiety Program, Bethesda, MD 20892 USA.
NR 34
TC 9
Z9 10
U1 0
U2 1
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST NW, WASHINGTON, DC 20005 USA
BN 978-1-58562-388-4
PY 2011
BP 305
EP 321
PG 17
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA BCF30
UT WOS:000310051000015
ER
PT J
AU Fauth, C
Baumann, M
Giunta, C
Krabichler, B
Ruschendorf, F
Bonnemann, CG
Bittner, RE
Colombi, M
Zoppi, N
Quijano-Roy, S
Romero, NB
Carlier, RY
Muntoni, F
Cirak, S
Schreiber, G
Amberger, A
Deutschmann, A
Straub, V
Rohrbach, M
Rostasy, K
Karall, D
Zschocke, J
AF Fauth, C.
Baumann, M.
Giunta, C.
Krabichler, B.
Rueschendorf, F.
Boennemann, C. G.
Bittner, R. E.
Colombi, M.
Zoppi, N.
Quijano-Roy, S.
Romero, N. B.
Carlier, R. Y.
Muntoni, F.
Cirak, S.
Schreiber, G.
Amberger, A.
Deutschmann, A.
Straub, V
Rohrbach, M.
Rostasy, K.
Karall, D.
Zschocke, J.
TI CONGENITAL MYOPATHY EHLERS-DANLOS OVERLAP SYNDROME CAUSED BY THE
DEFICIENCY OF AN ENZYME INVOLVED IN PROTEIN FOLDING IN THE ENDOPLASMIC
RETICULUM: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL DISORDER
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Meeting Abstract
C1 [Fauth, C.; Krabichler, B.; Amberger, A.; Deutschmann, A.; Zschocke, J.] Innsbruck Med Univ, Div Hum Genet, Innsbruck, Austria.
[Baumann, M.; Rostasy, K.; Karall, D.] Innsbruck Med Univ, Dept Paediatr 4, Innsbruck, Austria.
[Giunta, C.; Rohrbach, M.] Univ Child Hosp Zurich, Div Metabol, Zurich, Switzerland.
[Rueschendorf, F.] Max Delbruck Ctr Mol Med, Berlin, Germany.
[Boennemann, C. G.] NINDS, NIH, Bethesda, MD 20892 USA.
[Bittner, R. E.] Vienna Med Univ, Neuromusc Res Dept, Vienna, Austria.
[Colombi, M.; Zoppi, N.] Univ Brescia, Div Biol Genet, Brescia, Italy.
[Quijano-Roy, S.] Univ Versailles SQY, APHP, Serv Ped, Garches, France.
[Romero, N. B.] Gr Hop Univ Pitie Sal, Inst Myol, Paris, France.
[Carlier, R. Y.] Hop Raym Poinc, Dept Radiol, Garches, France.
[Muntoni, F.; Cirak, S.] Dubowitz Neuromusc Ctr, London, England.
[Schreiber, G.] Klin Kassel, Dept Neuropaed, Kassel, Germany.
[Straub, V] Newcastle Univ, Inst Hum Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PY 2011
VL 34
SU 3
BP S239
EP S239
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 020TP
UT WOS:000309837800556
ER
PT J
AU Ries, M
Benko, W
Wiggs, EA
Brady, RO
Schiffmann, R
FitzGibbon, EJ
AF Ries, M.
Benko, W.
Wiggs, E. A.
Brady, R. O.
Schiffmann, R.
FitzGibbon, E. J.
TI THE SACCADIC AND NEUROLOGICAL DEFICITS IN TYPE 3 GAUCHER DISEASE
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Meeting Abstract
C1 [Ries, M.] Ctr Pediat & Youth Med, Heidelberg, Germany.
[Benko, W.; Wiggs, E. A.; Brady, R. O.] NINDS, DMNB, NIH, Bethesda, MD 20892 USA.
[Schiffmann, R.] Baylor Res Inst, Dallas, TX USA.
[FitzGibbon, E. J.] NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PY 2011
VL 34
SU 3
BP S198
EP S198
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 020TP
UT WOS:000309837800431
ER
PT J
AU Ruoppolo, M
Caterino, C
Chandler, RJ
Venditti, CP
AF Ruoppolo, M.
Caterino, C.
Chandler, R. J.
Venditti, C. P.
TI DISSECTING MOLECULAR BASIS OF METHYLMALONIC ACIDEMIA (MMA) BY PROTEOMIC
ANALYSIS
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Meeting Abstract
C1 [Ruoppolo, M.] Univ Naples Federico II, DBBM, Naples, Italy.
[Caterino, C.] Fdn SDN, Naples, Italy.
[Chandler, R. J.; Venditti, C. P.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PY 2011
VL 34
SU 3
BP S238
EP S238
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 020TP
UT WOS:000309837800553
ER
PT B
AU Brooks, PJ
AF Brooks, Philip J.
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol as a Human Carcinogen
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID ESOPHAGEAL CANCER
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Brooks, PJ (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM pjbrooks@mail.nih.gov
NR 8
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 1
EP 4
DI 10.1007/978-1-4614-0040-0_1
D2 10.1007/978-1-4614-0040-0
PG 4
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600001
ER
PT B
AU Dunty, WC
AF Dunty, William C., Jr.
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Cancer and Alcohol: An Overview of Tumorigenesis
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID HUMAN COLORECTAL CANCERS; P53 GENE-MUTATIONS; INFLAMMATION; ONCOGENES;
DELETIONS; OCCUR
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Dunty, WC (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM duntyw@mail.nih.gov
NR 35
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 5
EP 18
DI 10.1007/978-1-4614-0040-0_2
D2 10.1007/978-1-4614-0040-0
PG 14
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600002
ER
PT B
AU Gentry, RT
AF Gentry, R. Thomas
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol and Cancer Epidemiology
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID HEPATITIS-C INFECTION; PRIMARY LIVER-CANCER; HEPATOCELLULAR-CARCINOMA;
BREAST-CANCER; RISK-FACTORS; LUNG-CANCER; COLORECTAL-CANCER; POOLED
ANALYSIS; THYROID-CANCER; UNITED-STATES
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Gentry, RT (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM tgentry@niaaa.nih.gov
NR 85
TC 3
Z9 3
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 19
EP 35
DI 10.1007/978-1-4614-0040-0_3
D2 10.1007/978-1-4614-0040-0
PG 17
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600003
ER
PT B
AU Murray, GJ
Brooks, PJ
Zakhari, S
AF Murray, Gary J.
Brooks, Philip J.
Zakhari, Samir
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol Metabolism and Its Implications for Cancer
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID DEHYDROGENASE 1C-ASTERISK-1 ALLELE; UPPER AERODIGESTIVE TRACT;
SQUAMOUS-CELL CARCINOMA; DIETARY-FOLATE INTAKE; BREAST-CANCER; ALDEHYDE
DEHYDROGENASE; GENETIC POLYMORPHISMS; CLASS-I; LIPID-PEROXIDATION;
OXIDATIVE STRESS
C1 [Murray, Gary J.; Brooks, Philip J.; Zakhari, Samir] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Zakhari, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM szakhari@mail.nih.gov; szakhari@mail.nih.gov
NR 139
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 37
EP 67
DI 10.1007/978-1-4614-0040-0_4
D2 10.1007/978-1-4614-0040-0
PG 31
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600004
ER
PT B
AU Hereld, D
Guo, QM
AF Hereld, Dale
Guo, Q. Max
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Epigenetics, Alcohol, and Cancer
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID GENOMIC DNA HYPERMETHYLATION; MESSENGER-RNA EXPRESSION;
COLORECTAL-CANCER; ETHANOL EXPOSURE; HISTONE H3; IN-VIVO;
HEPATOCELLULAR-CARCINOMA; METHIONINE METABOLISM; HEPATIC METHIONINE; RAT
HEPATOCYTES
C1 [Hereld, Dale; Guo, Q. Max] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Hereld, D (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM hereldd@mail.nih.gov
NR 89
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 69
EP 91
DI 10.1007/978-1-4614-0040-0_5
D2 10.1007/978-1-4614-0040-0
PG 23
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600005
ER
PT B
AU Dunty, WC
AF Dunty, William C., Jr.
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol, Cancer Genes, and Signaling Pathways
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION;
RECEPTOR-ALPHA EXPRESSION; ENDOTHELIAL GROWTH-FACTOR; ETHANOL-INDUCED
INVASION; TUMOR-SUPPRESSOR GENE; BREAST-CANCER;
HEPATOCELLULAR-CARCINOMA; TGF-BETA; IN-VITRO
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Dunty, WC (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM duntyw@mail.nih.gov
NR 194
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 93
EP 126
DI 10.1007/978-1-4614-0040-0_6
D2 10.1007/978-1-4614-0040-0
PG 34
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600006
ER
PT B
AU Radaeva, S
AF Radaeva, Svetlana
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol, Retinoic Acid, and Cancer
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID X-RECEPTOR-ALPHA; ADENOMATOUS POLYPOSIS-COLI; VITAMIN-A STATUS; HEPATIC
STELLATE CELLS; INTESTINAL MUCOSAL ALTERATIONS; MESSENGER-RNA
EXPRESSION; RAT-LIVER; ALL-TRANS; BREAST-CANCER; UP-REGULATION
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Radaeva, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM sradaeva@mail.nih.gov
NR 151
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 127
EP 153
DI 10.1007/978-1-4614-0040-0_7
D2 10.1007/978-1-4614-0040-0
PG 27
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600007
ER
PT B
AU Orosz, A
AF Orosz, Andras
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol, Altered Protein Homeostasis, and Cancer
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID HEAT-SHOCK FACTOR-1; TRANSCRIPTION FACTOR HSF1; KAPPA-B ACTIVATION;
FACTOR-I; DNA-BINDING; MOLECULAR CHAPERONE; GENE-EXPRESSION;
NUCLEAR-FACTOR; NITRIC-OXIDE; CELL-DEATH
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Orosz, A (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM orosza@mail.nih.gov
NR 76
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 155
EP 173
DI 10.1007/978-1-4614-0040-0_8
D2 10.1007/978-1-4614-0040-0
PG 19
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600008
ER
PT B
AU Wang, HJ
AF Wang, H. Joe
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Alcohol and the Inflammatory Function of Immune Cells in Cancer
Development
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID NF-KAPPA-B; HEPATITIS-C VIRUS; INDUCED LIVER-DISEASE;
HEPATOCELLULAR-CARCINOMA; TRANSCRIPTION FACTORS; INSULIN-RESISTANCE;
SUPPRESSOR-CELLS; VIRAL-HEPATITIS; TARGET GENES; EXPRESSION
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Wang, HJ (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM Wangh4@mail.nih.gov
NR 83
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 175
EP 192
DI 10.1007/978-1-4614-0040-0_9
D2 10.1007/978-1-4614-0040-0
PG 18
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600009
ER
PT B
AU Jung, MK
AF Jung, M. Katherine
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Immune Surveillance and Tumor Evasion
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID NATURAL-KILLER-CELLS; CHRONIC ALCOHOL-CONSUMPTION; CLASS-I PHENOTYPES;
MHC CLASS-I; T-CELLS; SUPPRESSOR-CELLS; NK CELL; DENDRITIC CELLS; B16BL6
MELANOMA; CONSUMING MICE
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Jung, MK (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM jungma@mail.nih.gov
NR 78
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 193
EP 210
DI 10.1007/978-1-4614-0040-0_10
D2 10.1007/978-1-4614-0040-0
PG 18
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600010
ER
PT B
AU Gao, Z
Guo, QM
AF Gao, Zhigang (Peter)
Guo, Q. Max
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Stem Cells and Alcohol-Related Cancers
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
ID ACUTE MYELOID-LEUKEMIA; ALDEHYDE DEHYDROGENASE; PROGENITOR CELLS;
HEPATOCELLULAR-CARCINOMA; LIVER; CARCINOGENESIS; MARKER; EXPANSION;
RENEWAL; MODEL
C1 [Gao, Zhigang (Peter); Guo, Q. Max] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Guo, QM (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM qmguo@mail.nih.gov; qmguo@mail.nih.gov
NR 41
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 211
EP 223
DI 10.1007/978-1-4614-0040-0_11
D2 10.1007/978-1-4614-0040-0
PG 13
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600011
ER
PT B
AU Zakhari, S
AF Zakhari, Samir
BE Zakhari, S
Vasiliou, V
Guo, QM
TI Epilogue, Consensus Recommendations: Alcohol and Cancer
SO ALCOHOL AND CANCER
LA English
DT Article; Book Chapter
C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
RP Zakhari, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA.
EM szakhari@mail.nih.gov; szakhari@mail.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0039-4
PY 2011
BP 225
EP 232
DI 10.1007/978-1-4614-0040-0_12
D2 10.1007/978-1-4614-0040-0
PG 8
WC Oncology; Substance Abuse
SC Oncology; Substance Abuse
GA BBA45
UT WOS:000306294600012
ER
PT J
AU Jozwiak, K
Plazinska, A
Toll, L
Jimenez, L
Woo, AYH
Xiao, RP
Wainer, IW
AF Jozwiak, Krzysztof
Plazinska, Anita
Toll, Lawrence
Jimenez, Lucita
Woo, Anthony Yiu-Ho
Xiao, Rui-Ping
Wainer, Irving W.
TI Effect of Fenoterol Stereochemistry on the beta 2 Adrenergic Receptor
System: Ligand-Directed Chiral Recognition
SO CHIRALITY
LA English
DT Article; Proceedings Paper
CT 22nd International Symposium on Chirality
CY 2010
CL Sapporo, JAPAN
DE G protein-coupled receptors; beta(2) adrenergic agonists;
stereoselective binding; affinity; efficacy; Van't Hoff analysis
ID PROTEIN-COUPLED RECEPTOR; MOLECULAR-FIELD ANALYSIS; BETA(2)-ADRENERGIC
RECEPTOR; STEREOISOMERS; AGONISTS; BINDING; ADRENOCEPTOR; DERIVATIVES;
ACTIVATION; SEPARATION
AB The beta(2) adrenergic receptor (beta(2)-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a beta(2)-AR selective agonist that has two centers of chirality and exists as four stereoisomers. Radioligand binding studies determined that stereochemistry greatly influences the binding affinity. Subsequent Van't Hoff analysis shows very different thermodynamics of binding depending on the stereoconfiguration of the molecule. The binding of (S, x')-isomers is almost entirely enthalpy controlled whereas binding of (R, x')-isomers is purely entropy driven. Stereochemistry of FEN molecule also affects the coupling of the receptor to different G proteins. In a rat cardiomyocyte contractility model, (R, R')-FEN was shown to selectively activate Gs protein signaling while the (S, R')-isomer activated both G(i) and G(s) protein. The overall data demonstrate that the chirality at the two chiral centers of the FEN molecule influences the magnitude of binding affinity, thermodynamics of local interactions within the binding site, and the global mechanism of beta(2)-AR activation. Differences in thermodynamic parameters and nonuniform G-protein coupling suggest a mechanism of chiral recognition in which observed enantioselectivities arise from the interaction of the (R, x')-FEN stereoisomers with a different receptor conformation than the one with which the (S, x')-isomer interacts. Chirality 23: E1-E6, 2011. (C) 2011 Wiley Periodicals, Inc.
C1 [Jozwiak, Krzysztof; Plazinska, Anita] Med Univ Lublin, Lab Med Chem & Neuroengn, PL-20093 Lublin, Poland.
[Toll, Lawrence; Jimenez, Lucita] SRI Int, Neuropharmacol Program, Menlo Pk, CA 94025 USA.
[Woo, Anthony Yiu-Ho; Xiao, Rui-Ping; Wainer, Irving W.] NIA, Clin Invest Lab, Baltimore, MD 21224 USA.
RP Jozwiak, K (reprint author), Med Univ Lublin, Lab Med Chem & Neuroengenering, Ul Chodzki 4A, PL-20093 Lublin, Poland.
EM krzysztof.jozwiak@umlub.pl
RI Woo, Anthony/D-4305-2014
OI Woo, Anthony/0000-0003-0662-698X
FU Intramural NIH HHS [ZIA AG000297-09]; NIDA NIH HHS [HHSN271201000001I,
HHSN271201000001W]; PHS HHS [HHSN2712010000081]
NR 21
TC 10
Z9 10
U1 0
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-0042
J9 CHIRALITY
JI Chirality
PY 2011
VL 23
IS 1E
SI SI
BP E1
EP E6
DI 10.1002/chir.20963
PG 6
WC Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic;
Pharmacology & Pharmacy
SC Pharmacology & Pharmacy; Chemistry
GA 010DG
UT WOS:000309074200001
PM 21618615
ER
PT B
AU Tatusova, T
AF Tatusova, Tatiana
BE Pellegrini, M
Fred, A
Filipe, J
Gamboa, H
TI INFRASTRUCTURE FOR METAGENOME DATA MANAGEMENT AND ANALYSIS
SO BIOINFORMATICS 2011
LA English
DT Proceedings Paper
CT International Conferene on Bioinformatics Models, Methods and Algorithms
CY JAN 26-29, 2011
CL Rome, ITALY
SP Inst Syst & Technol Informat, Control & Commun, IEEE, Engn Med & Biol Soc, IEEE, Portugal EMBS Chapter, ESEM, BMES
DE Database; Sequence analysis; Metagenomics
ID BLAST; SEQUENCES
AB Metagenome sequencing projects are generating unprecedented amounts of data. Public sequence archive databases are challenged with large-scale data management issues including data storage, quick search and retrieval of the sequence data for further analysis. The sequence data is linked to the rich set of metadata attributes such as geochemical and ecological parameters for environmental projects and clinical patient information for human microbiome studies. That complex collection of heterogeneous information has to be integrated, organized and presented to the users in a meaningful and the most useful way. For the last 20 years The National Center for Biotechnology Information (NCBI) has been developing the infrastructure that allows an easy storage and distribution of various types of bimolecular data as well as data integration and easy navigation in complex information space. Here we describe NCBI resources that are used for metagenomics data management.
C1 NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Tatusova, T (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, 9600 Rockville Pike, Bethesda, MD 20892 USA.
NR 9
TC 0
Z9 0
U1 0
U2 2
PU SCITEPRESS
PI SETUBAL
PA AV D MANUELL, 27A 2 ESQ, SETUBAL, 2910-595, PORTUGAL
BN 978-989-8425-36-2
PY 2011
BP 357
EP 362
PG 6
WC Medical Informatics
SC Medical Informatics
GA BBW54
UT WOS:000308455800059
ER
PT J
AU Kristensen, DM
Mushegian, AR
Koonin, EV
AF Kristensen, David M.
Mushegian, Arcady R.
Koonin, Eugene V.
TI Systems biology of bacteriophage proteins and new dimensions of the
virus world discovered through metagenomics
SO GENOME BIOLOGY
LA English
DT Meeting Abstract
C1 [Kristensen, David M.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
[Mushegian, Arcady R.] Stowers Inst Med Res, Dept Bioinformat, Kansas City, MO 64110 USA.
[Mushegian, Arcady R.] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1474-7596
J9 GENOME BIOL
JI Genome Biol.
PY 2011
VL 12
SU 1
MA P9
BP 9
EP 9
PG 1
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 002QH
UT WOS:000308546700024
ER
PT J
AU Rope, AF
Wang, K
Evjenth, R
Xing, JC
Johnston, JJ
Swensen, JJ
Johnson, WE
Moore, B
Huff, CD
Bird, LM
Carey, JC
Opitz, JM
Stevens, CA
Schank, C
Fain, HD
Robison, R
Dalley, B
Chin, S
South, ST
Pysher, TJ
Jorde, LB
Hakonarson, H
Lillehaug, JR
Biesecker, LG
Yandell, M
Arnesen, T
Lyon, GJ
AF Rope, Alan F.
Wang, Kai
Evjenth, Rune
Xing, Jinchuan
Johnston, Jennifer J.
Swensen, Jeffrey J.
Johnson, W. Evan
Moore, Barry
Huff, Chad D.
Bird, Lynne M.
Carey, John C.
Opitz, John M.
Stevens, Cathy A.
Schank, Christa
Fain, Heidi Deborah
Robison, Reid
Dalley, Brian
Chin, Steven
South, Sarah T.
Pysher, Theodore J.
Jorde, Lynn B.
Hakonarson, Hakon
Lillehaug, Johan R.
Biesecker, Leslie G.
Yandell, Mark
Arnesen, Thomas
Lyon, Gholson J.
TI Massively parallel sequencing identifies a previously unrecognized
X-linked disorder resulting in lethality in male infants owing to
amino-terminal acetyltransferase deficiency
SO GENOME BIOLOGY
LA English
DT Meeting Abstract
C1 [Rope, Alan F.; Carey, John C.; Opitz, John M.; South, Sarah T.] Univ Utah, Sch Med, Dept Pediat Med Genet, Salt Lake City, UT USA.
[Wang, Kai; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[Evjenth, Rune; Lillehaug, Johan R.; Arnesen, Thomas] Univ Bergen, Dept Mol Biol, N-5020 Bergen, Norway.
[Xing, Jinchuan; Moore, Barry; Huff, Chad D.; Opitz, John M.; Jorde, Lynn B.; Yandell, Mark] Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT USA.
[Johnston, Jennifer J.; Biesecker, Leslie G.] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
[Swensen, Jeffrey J.; Opitz, John M.; Chin, Steven; Pysher, Theodore J.] Univ Utah, Dept Pathol, Salt Lake City, UT USA.
[Swensen, Jeffrey J.; South, Sarah T.] ARUP Labs, Salt Lake City, UT USA.
[Johnson, W. Evan; Schank, Christa] Brigham Young Univ, Dept Stat, Provo, UT 84602 USA.
[Bird, Lynne M.] Rady Childrens Hosp, San Diego, CA USA.
[Bird, Lynne M.] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
[Opitz, John M.] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT 84132 USA.
[Stevens, Cathy A.] Univ Tennessee, Dept Pediat, Coll Med, Chattanooga, TN USA.
[Fain, Heidi Deborah; Robison, Reid; Lyon, Gholson J.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA.
[Dalley, Brian] Huntsman Canc Inst, Salt Lake City, UT USA.
[Arnesen, Thomas] Haukeland Hosp, Dept Surg, N-5021 Bergen, Norway.
[Lyon, Gholson J.] NYU, Ctr Child Study, New York, NY USA.
RI Lyon, Gholson/D-2765-2014
OI Lyon, Gholson/0000-0002-5869-0716
NR 0
TC 0
Z9 0
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1474-7596
J9 GENOME BIOL
JI Genome Biol.
PY 2011
VL 12
SU 1
MA P13
BP 11
EP 11
PG 1
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 002QH
UT WOS:000308546700027
ER
PT J
AU Tang, W
Fu, YP
Figueroa, JD
Malats, N
Garcia-Closas, M
Chatterjee, N
Kogevinas, M
Baris, D
Thun, M
Hall, JL
De Vivo, I
Albanes, D
Porter-Gill, P
Purdue, MP
Burdett, L
Liu, LY
Hutchinson, A
Myers, T
Tardon, A
Serra, C
Carrato, A
Garcia-Closas, R
Lloreta, J
Johnson, A
Schwenn, M
Karagas, MR
Schned, A
Black, A
Jacobs, EJ
Diver, R
Gapstur, SM
Virtamo, J
Hunter, DJ
Fraumeni, JF
Chanock, SJ
Silverman, DT
Rothman, N
Prokunina-Olsson, L
AF Tang, Wei
Fu, Yi-Ping
Figueroa, Jonine D.
Malats, Nuria
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Kogevinas, Manolis
Baris, Dalsu
Thun, Michael
Hall, Jennifer L.
De Vivo, Immaculata
Albanes, Demetrius
Porter-Gill, Patricia
Purdue, Mark P.
Burdett, Laurie
Liu, Luyang
Hutchinson, Amy
Myers, Timothy
Tardon, Adonina
Serra, Consol
Carrato, Alfredo
Garcia-Closas, Reina
Lloreta, Josep
Johnson, Alison
Schwenn, Molly
Karagas, Margaret R.
Schned, Alan
Black, Amanda
Jacobs, Eric J.
Diver, Ryan
Gapstur, Susan M.
Virtamo, Jarmo
Hunter, David J.
Fraumeni, Joseph F., Jr.
Chanock, Stephen J.
Silverman, Debra T.
Rothman, Nathaniel
Prokunina-Olsson, Ludmila
TI An unusual suspect: an uncommon human-specific synonymous coding variant
within the UGT1A6 gene explains a GWAS signal and protects against
bladder cancer
SO GENOME BIOLOGY
LA English
DT Meeting Abstract
C1 [Tang, Wei; Fu, Yi-Ping; Porter-Gill, Patricia; Liu, Luyang; Chanock, Stephen J.; Prokunina-Olsson, Ludmila] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Malats, Nuria] Spanish Natl Canc Res Ctr, Madrid 28029, Spain.
[Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
[Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.
[Kogevinas, Manolis] Municipal Inst Med Res, Barcelona 08003, Spain.
[Kogevinas, Manolis] CIBER Epidemiol Salud Publ CIBERESP, Barcelona 08003, Spain.
[Kogevinas, Manolis] Natl Sch Publ Hlth, Athens 11521, Greece.
[Thun, Michael; Jacobs, Eric J.; Diver, Ryan; Gapstur, Susan M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA.
[Hall, Jennifer L.] Univ Minnesota, Lillehei Heart Inst, Dept Med, Minneapolis, MN 55455 USA.
[De Vivo, Immaculata] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA.
[Burdett, Laurie; Hutchinson, Amy; Myers, Timothy] NCI, Core Genotype Facil, SAIC Frederick, Frederick, MD 21702 USA.
[Tardon, Adonina] Univ Oviedo, Oviedo 33003, Spain.
[Serra, Consol] Univ Pompeu Fabra, Barcelona 08002, Spain.
[Carrato, Alfredo] Ramon & Cajal Univ Hosp, Madrid 28034, Spain.
[Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna 38320, Spain.
[Lloreta, Josep] Univ Pompeu Fabra, Hosp del Mar, Inst Municipal Invest Med IMIM, Barcelona 08003, Spain.
[Johnson, Alison] Vermont Canc Registry, Burlington, VT 05401 USA.
[Schwenn, Molly] Maine Canc Registry, Augusta, ME 04333 USA.
[Karagas, Margaret R.] Dartmouth Med Sch, Hanover, NH 03755 USA.
[Schned, Alan] Washington Univ, Sch Med, Dept Urol, St Louis, MO 63110 USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki 00271, Finland.
[Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA.
RI Serra, C/E-6879-2014; Lloreta, J/I-2112-2014; Albanes,
Demetrius/B-9749-2015; Garcia-Closas, Montserrat /F-3871-2015; Malats,
Nuria/H-7041-2015; Purdue, Mark/C-9228-2016; Kogevinas,
Manolis/C-3918-2017
OI Serra, C/0000-0001-8337-8356; Lloreta, J/0000-0003-1644-9470;
Garcia-Closas, Montserrat /0000-0003-1033-2650; Malats,
Nuria/0000-0003-2538-3784; Purdue, Mark/0000-0003-1177-3108;
NR 0
TC 0
Z9 0
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1474-7596
J9 GENOME BIOL
JI Genome Biol.
PY 2011
VL 12
SU 1
MA P19
BP 13
EP 13
PG 1
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 002QH
UT WOS:000308546700032
ER
PT J
AU Cer, RZ
Bruce, KH
Donohue, DE
Temiz, AN
Bacolla, A
Mudunuri, US
Yi, M
Volfovsky, N
Luke, BT
Collins, JR
Stephens, RM
AF Cer, Regina Z.
Bruce, Kevin H.
Donohue, Duncan E.
Temiz, Alpay N.
Bacolla, Albino
Mudunuri, Uma S.
Yi, Ming
Volfovsky, Natalia
Luke, Brian T.
Collins, Jack R.
Stephens, Robert M.
TI Introducing the non-B DNA Motif Search Tool (nBMST)
SO GENOME BIOLOGY
LA English
DT Meeting Abstract
C1 [Cer, Regina Z.; Bruce, Kevin H.; Donohue, Duncan E.; Temiz, Alpay N.; Bacolla, Albino; Mudunuri, Uma S.; Luke, Brian T.; Collins, Jack R.; Stephens, Robert M.] NCI, Adv Biomed Comp Ctr, Informat Syst Program, SAIC Frederick, Frederick, MD 21702 USA.
[Bacolla, Albino] Univ Texas Austin, Dell Pediat Res Inst, Dept Pharm, Austin, TX 78723 USA.
RI Bacolla, Albino/N-3877-2013
OI Bacolla, Albino/0000-0003-0206-8423
NR 2
TC 0
Z9 0
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1474-7596
J9 GENOME BIOL
JI Genome Biol.
PY 2011
VL 12
SU 1
MA P34
BP 20
EP 20
PG 1
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 002QH
UT WOS:000308546700047
ER
PT J
AU Kitanaka, N
Kitanaka, J
Watabe, K
Hall, FS
Uhl, GR
Tanaka, K
Nishiyama, N
Takemura, M
AF Kitanaka, Nobue
Kitanaka, Junichi
Watabe, Kaname
Hall, F. Scott
Uhl, George R.
Tanaka, Koh-ichi
Nishiyama, Nobuyoshi
Takemura, Motohiko
TI Acute administration of methamphetamine decreases running wheel activity
in mice
SO NEUROSCIENCE RESEARCH
LA English
DT Meeting Abstract
C1 [Kitanaka, Nobue; Kitanaka, Junichi; Takemura, Motohiko] Hyogo Coll Med, Dept Pharmacol, Nishinomiya, Hyogo 6638501, Japan.
[Watabe, Kaname] Muromachi Kikai Co Ltd, Tech Dept, Tokyo, Japan.
[Hall, F. Scott; Uhl, George R.] NIDA, IRP, NIH, DHHS, Baltimore, MD USA.
[Tanaka, Koh-ichi; Nishiyama, Nobuyoshi] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Div Pharmacol, Kobe, Hyogo, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PY 2011
VL 71
SU S
BP E396
EP E396
DI 10.1016/j.neures.2011.07.1738
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA 998DT
UT WOS:000308218102209
ER
PT J
AU Santos, GS
Gireesh, ED
Yu, S
Plenz, D
Nakahara, H
AF Santos, Gustavo S.
Gireesh, Elakkat D.
Yu, Shan
Plenz, Dietmar
Nakahara, Hiroyuki
TI The hierarchical model captures higher-order interactions in cortical
activity
SO NEUROSCIENCE RESEARCH
LA English
DT Meeting Abstract
C1 [Santos, Gustavo S.; Nakahara, Hiroyuki] RIKEN Brain Sci Inst, Lab Integrated Theor Neurosci, Wako, Saitama, Japan.
[Gireesh, Elakkat D.] New York U, Dept Neurol, New York, NY USA.
[Yu, Shan; Plenz, Dietmar] NIMH, Sect Crit Brain Dynam, Lab Sys Neurosci, Bethesda, MD 20892 USA.
[Nakahara, Hiroyuki] Tokyo Inst Tech, Dept Comp Intel & Sys Sci, Yokohama, Kanagawa, Japan.
RI Nakahara, Hiroyuki/N-5411-2015
OI Nakahara, Hiroyuki/0000-0001-6891-1175
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PY 2011
VL 71
SU S
BP E307
EP E307
DI 10.1016/j.neures.2011.07.1337
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA 998DT
UT WOS:000308218101580
ER
PT J
AU Suzuki, N
Hirasawa, E
Yamada, Y
Akazawa, C
AF Suzuki, Nobuharu
Hirasawa, Eri
Yamada, Yoshihiko
Akazawa, Chihiro
TI Oligodendrocyte development and dysmyelinating diseases: Teneurin-4 as a
novel regulator of CNS myelination
SO NEUROSCIENCE RESEARCH
LA English
DT Meeting Abstract
C1 [Suzuki, Nobuharu; Akazawa, Chihiro] Tokyo Med Dent Univ, Grad Sch Healthcare Sci, Dep Biochem & Biophys, Tokyo, Japan.
[Suzuki, Nobuharu; Yamada, Yoshihiko] NIDCR, NIH, Bethesda, MD USA.
[Hirasawa, Eri] Juntendo Univ, Res Inst Disea Old Age, Tokyo, Japan.
[Hirasawa, Eri] Juntendo Univ, Facul Med, Dep Neurol, Tokyo, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PY 2011
VL 71
SU S
BP E25
EP E26
DI 10.1016/j.neures.2011.07.108
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA 998DT
UT WOS:000308218100105
ER
PT J
AU Klee, MM
AF Klee, Maurice M.
TI The Case of the Unanswered Question
SO IEEE PULSE
LA English
DT Editorial Material
C1 [Klee, Maurice M.] NIH, Bethesda, MD 20892 USA.
[Klee, Maurice M.] Michigan State Univ, Coll Engn, E Lansing, MI 48824 USA.
EM mk@maurieklee.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2154-2287
J9 IEEE PULSE
JI IEEE Pulse
PD JAN-FEB
PY 2011
VL 2
IS 1
BP 49
EP 49
DI 10.1109/MPUL.2010.939612
PG 1
WC Engineering, Biomedical
SC Engineering
GA 992DG
UT WOS:000307755200016
ER
PT S
AU Filipovych, R
Resnick, SM
Davatzikos, C
AF Filipovych, Roman
Resnick, Susan M.
Davatzikos, Christos
BE Suzuki, K
Wang, F
Shen, DG
Yan, PK
TI Multi-Kernel Classification for Integration of Clinical and Imaging
Data: Application to Prediction of Cognitive Decline in Older Adults
SO MACHINE LEARNING IN MEDICAL IMAGING
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 2nd International Workshop on Machine Learning in Medical Imaging (MLMI
2011)
CY SEP 18, 2011
CL Toronto, CANADA
DE Multi-Kernel Learning (MKL); Normal aging; MRI
ID ATROPHY; BRAIN
AB Diagnosis of neurologic and neuropsychiatric disorders typically involves considerable assessment including clinical observation, neuroimaging, and biological and neuropsychological measurements. While it is reasonable to expect that the integration of neuroimaging data and complementary non-imaging measures is likely to improve early diagnosis on individual basis, due to technical challenges associated with the task of combining different data types, medical image pattern recognition analysis has been largely focusing solely on neuroimaging evaluations. In this paper, we explore the potential of integrating neuroimaging and clinical information within a pattern classification framework, and propose that the multi-kernel learning (MKL) paradigm may be suitable for building a multimodal classifier of a disorder, as well as for automatic identification of the relevance of each information type. We apply our approach to the problem of detecting cognitive decline in healthy older adults from single-visit evaluations, and show that the performance of a classifier can be improved when nouroimaging and clinical evaluations are used simultaneously within a MKL-based classification framework.
C1 [Filipovych, Roman; Davatzikos, Christos] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA.
[Resnick, Susan M.] Biomed Res Ctr, Lab Personal Cognit, Baltimore, MD 21224 USA.
RP Filipovych, R (reprint author), Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA.
FU Intramural Research Program of the NIH; National Institute on Aging
(NIA) [R01-AG14971, N01-AG-3-2124]
FX This research was supported in part by the Intramural Research Program
of the NIH, National Institute on Aging (NIA), and R01-AG14971,
N01-AG-3-2124, N01-AG-3-2124.
NR 20
TC 4
Z9 4
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24318-9
J9 LECT NOTES COMPUT SC
PY 2011
VL 7009
BP 26
EP +
PG 3
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
Methods; Radiology, Nuclear Medicine & Medical Imaging
SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging
GA BBA61
UT WOS:000306302100004
ER
PT S
AU Bagci, U
Yao, JH
Caban, J
Suffredini, AF
Palmore, TN
Mollura, DJ
AF Bagci, Ulas
Yao, Jianhua
Caban, Jesus
Suffredini, Anthony F.
Palmore, Tara N.
Mollura, Daniel J.
BE Fichtinger, G
Martel, A
Peters, T
TI Learning Shape and Texture Characteristics of CT Tree-in-Bud Opacities
for CAD Systems
SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011,
PT III
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 14th International Conference on Medical Image Computing and
Computer-Assisted Intervention (MICCAI 2011)
CY SEP 18-22, 2011
CL Toronto, CANADA
DE Tree-in-Bud; Willmore Energy; Lung; Infectious Diseases; Computer
Assisted Detection
ID SEGMENTATION
AB Although radiologists can employ CAD systems to characterize malignancies, pulmonary fibrosis and other chronic diseases; the design of imaging techniques to quantify infectious diseases continue to lag behind. There exists a need to create more CAD systems capable of detecting and quantifying characteristic patterns often seen in respiratory tract infections such as influenza, bacterial pneumonia, or tuborculosis. One of such patterns is Tree-in-bud (TIB) which presents thickened bronchial structures surrounding by clusters of micro-nodules. Automatic detection of TIB patterns is a challenging task because of their weak boundary, noisy appearance, and small lesion size. In this paper, we present two novel methods for automatically detecting TIB patterns: (1) a fast localization of candidate patterns using information from local scale of the images, and (2) a Mobius invariant feature extraction method based on learned local shape and texture properties. A comparative evaluation of the proposed methods is presented with a dataset of 39 laboratory confirmed viral bronchiolitis human parainfluenza (HPIV) CTs and 21 normal lung CTs. Experimental results demonstrate that the proposed CAD system can achieve high detection rate with an overall accuracy of 90.96%.
C1 [Bagci, Ulas; Yao, Jianhua; Mollura, Daniel J.] NIH, Dept Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA.
[Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
[Suffredini, Anthony F.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
[Palmore, Tara N.] NIH, Lab Clin Infect Dis, Bethesda, MD 20892 USA.
RP Bagci, U (reprint author), NIH, Dept Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA.
EM ulas.bagci@nih.gov
OI Bagci, Ulas/0000-0001-7379-6829
NR 7
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-23625-9; 978-3-642-23626-6
J9 LECT NOTES COMPUT SC
PY 2011
VL 6893
BP 215
EP +
PN III
PG 2
WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine &
Medical Imaging
SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging
GA BBI77
UT WOS:000306990200027
ER
PT S
AU Cao, YH
Yuan, Y
Li, XL
Turkbey, B
Choyke, PL
Yan, PK
AF Cao, Yihui
Yuan, Yuan
Li, Xuelong
Turkbey, Baris
Choyke, Peter L.
Yan, Pingkun
BE Fichtinger, G
Martel, A
Peters, T
TI Segmenting Images by Combining Selected Atlases on Manifold
SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011,
PT III
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 14th International Conference on Medical Image Computing and
Computer-Assisted Intervention (MICCAI 2011)
CY SEP 18-22, 2011
CL Toronto, CANADA
ID SEGMENTATION; STRATEGIES
AB Atlas selection and combination are two critical factors affecting the performance of atlas-based segmentation methods. In the existing works, those tasks are completed in the original image space. However, the intrinsic similarity between the images may not be accurately reflected by the Euclidean distance in this high-dimensional space. Thus, the selected atlases may be away from the input image and the generated template by combining those atlases for segmentation can be misleading. In this paper, we propose to select and combine atlases by projecting the images onto a low-dimensional manifold. With this approach, atlases can be selected according to their intrinsic similarity to the patient image. A novel method is also proposed to compute the weights for more efficiently combining the selected atlases to achieve better segmentation performance. The experimental results demonstrated that our proposed method is robust and accurate, especially when the number of training samples becomes large.
C1 [Cao, Yihui; Yuan, Yuan; Li, Xuelong; Yan, Pingkun] Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Ctr OPT IMagery Anal & Learning OPTIMAL, Xian 710119, Shaanxi, Peoples R China.
[Turkbey, Baris; Choyke, Peter L.] NIH, Natl Canc Inst, Mol Imaging Program, Bethesda, MD 20892 USA.
RP Cao, YH (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Ctr OPT IMagery Anal & Learning OPTIMAL, Xian 710119, Shaanxi, Peoples R China.
FU National Basic Research Program of China [2011CB707000]; National
Natural Science Foundation of China [61072093]
FX The presented research work is supported by the National Basic Research
Program of China (973 Program) (Grant No. 2011CB707000) and the National
Natural Science Foundation of China (Grant No. 61072093).
NR 9
TC 25
Z9 25
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-23625-9; 978-3-642-23626-6
J9 LECT NOTES COMPUT SC
PY 2011
VL 6893
BP 272
EP +
PN III
PG 2
WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine &
Medical Imaging
SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging
GA BBI77
UT WOS:000306990200034
ER
PT S
AU Lu, XG
Jolly, MP
Georgescu, B
Hayes, C
Speier, P
Schmidt, M
Bi, XM
Kroeker, R
Comaniciu, D
Kellman, P
Mueller, E
Guehring, J
AF Lu, Xiaoguang
Jolly, Marie-Pierre
Georgescu, Bogdan
Hayes, Carmel
Speier, Peter
Schmidt, Michaela
Bi, Xiaoming
Kroeker, Randall
Comaniciu, Dorin
Kellman, Peter
Mueller, Edgar
Guehring, Jens
BE Fichtinger, G
Martel, A
Peters, T
TI Automatic View Planning for Cardiac MRI Acquisition
SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011,
PT III
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 14th International Conference on Medical Image Computing and
Computer-Assisted Intervention (MICCAI 2011)
CY SEP 18-22, 2011
CL Toronto, CANADA
ID IMAGES; MODELS
AB Conventional cardiac MRI acquisition involves a multi-step approach, requiring a few double-oblique localizers in order to locate the heart and prescribe long- and short-axis views of the heart. This approach is operator-dependent and time-consuming. We propose a new approach to automating and accelerating the acquisition process to improve the clinical workflow. We capture a highly accelerated static 3D full-chest volume through parallel imaging within one breath-hold. The left ventricle is localized and segmented, including left ventricle outflow tract. A number of cardiac landmarks are then detected to anchor the cardiac chambers and calculate standard 2-, 3-, and 4-chamber long-axis views along with a short-axis stack. Learning-based algorithms are applied to anatomy segmentation and anchor detection. The proposed algorithm is evaluated on 173 localizer acquisitions. The entire view planning is fully automatic and takes less than 10 seconds in our experiments.
C1 [Lu, Xiaoguang; Jolly, Marie-Pierre; Georgescu, Bogdan; Comaniciu, Dorin] Siemens Corp Res, Image Analyt & Informat, Princeton, NJ USA.
[Hayes, Carmel; Speier, Peter; Schmidt, Michaela; Mueller, Edgar; Guehring, Jens] Siemens AG, Healthcare Sect, Erlangen, Germany.
[Bi, Xiaoming] Siemens Med Solut USA, Chicago, IL USA.
[Kroeker, Randall] Siemens Med Solut Canada, Winnipeg, MB, Canada.
[Kellman, Peter] Natl Inst Hlth, Bethesda, MD USA.
RP Lu, XG (reprint author), Siemens Corp Res, Image Analyt & Informat, Princeton, NJ USA.
EM xiaoguang.lu@siemens.com
NR 12
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-23625-9; 978-3-642-23626-6
J9 LECT NOTES COMPUT SC
PY 2011
VL 6893
BP 479
EP +
PN III
PG 2
WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine &
Medical Imaging
SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging
GA BBI77
UT WOS:000306990200059
ER
PT S
AU Cohen, T
Widdows, D
Schvaneveldt, R
Rindflesch, TC
AF Cohen, Trevor
Widdows, Dominic
Schvaneveldt, Roger
Rindflesch, Thomas C.
BE Song, D
Melucci, M
Frommholz, I
Zhang, P
Wang, L
Arafat, S
TI Finding Schizophrenia's Prozac Emergent Relational Similarity in
Predication Space
SO QUANTUM INTERACTION
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 5th International Symposium on Quantum Interaction
CY JUN 26-29, 2011
CL Aberdeen, SCOTLAND
SP Scottish Informat & Comp Sci Alliance
DE Distributional Semantics; Vector Symbolic Architectures;
Literature-based Discovery; Abductive Reasoning
ID LITERATURE-BASED DISCOVERY; REPRESENTATION; KNOWLEDGE; ANALOGY; SYSTEM
AB In this paper, we investigate the ability of the Predication-based Semantic Indexing (PSI) approach, which incorporates both symbolic and distributional information, to support inference on the basis of structural similarity. For example, given a pair of related concepts prozac:depression, we attempt to identify concepts that relate to a third concept, such as schizophrenia in the same way. A novel PSI implementation based on Kanerva's Binary Spatter Code is developed, and evaluated on over 100,000 searches across 180,285 unique concepts and multiple typed relations. PSI is shown to retrieve with accuracy concepts on the basis of shared single and paired relations, given either a single strong example pair, or the superposition of a set of weaker examples. Search space size is identical for single and double relations, providing an efficient means to direct search across predicate paths for the purpose of literature-based discovery.
C1 [Cohen, Trevor] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77225 USA.
[Widdows, Dominic] Google Inc, Santa Clara, CA USA.
[Schvaneveldt, Roger] Arizona State Univ, Tempe, AZ USA.
[Rindflesch, Thomas C.] Natl Lib Med, Bethesda, MD USA.
RP Cohen, T (reprint author), Univ Texas Hlth Sci Ctr Houston, Houston, TX 77225 USA.
FU US National Library of Medicine [R21LM010826-01]; Google Inc.
FX This research was supported in part by the US National Library of
Medicine grant (R21LM010826-01). The authors would also like to
acknowledge Google Inc. for their support of author DWs ongoing research
on the subject.
NR 30
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24970-9
J9 LECT NOTES COMPUT SC
PY 2011
VL 7052
BP 48
EP +
PG 3
WC Computer Science, Interdisciplinary Applications; Computer Science,
Theory & Methods; Physics, Multidisciplinary
SC Computer Science; Physics
GA BBI79
UT WOS:000306990400006
ER
PT J
AU Wake, H
Fields, RD
AF Wake, Hiroaki
Fields, R. Douglas
TI Physiological function of microglia
SO NEURON GLIA BIOLOGY
LA English
DT Article
DE Microglia; neurogenesis; synaptic plasticity; Rett syndrome; autism;
chronic pain
ID IN-VIVO; CELLS; TERMINALS; SYNAPSES
AB Broad interest in the rapidly advancing field of microglial involvement in forming neural circuits is evident from the fresh findings published in leading journals. This special issue of Neuron Glia Biology contains a special collection of research articles and reviews concerning the new appreciation of microglial function in the normal physiology of the brain that extends beyond their traditionally understood role in pathology.
C1 [Wake, Hiroaki; Fields, R. Douglas] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Nervous Syst Dev & Plast Sect, Bethesda, MD 20892 USA.
RP Wake, H (reprint author), Natl Inst Nat Sci, Natl Inst Basic Biol, Div Brain Circuits, Room 384,Nishigonaka 38, Okazaki, Aichi 4448585, Japan.
EM hirowake@nibb.ac.jp
FU Intramural NIH HHS [ZIA HD000713-15]
NR 20
TC 0
Z9 1
U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1740-925X
J9 NEURON GLIA BIOL
JI Neuron Glia Biol.
PY 2011
VL 7
IS 1
SI SI
BP 1
EP 3
DI 10.1017/S1740925X12000166
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA 984FH
UT WOS:000307175000001
PM 22857736
ER
PT J
AU Wong, WT
Wang, MH
Li, W
AF Wong, Wai T.
Wang, Minhua
Li, Wei
TI Regulation of microglia by ionotropic glutamatergic and GABAergic
neurotransmission
SO NEURON GLIA BIOLOGY
LA English
DT Article
DE Microglial motility; purinergic transmission; ATP; pannexin channels;
neuronal activity
ID ATP RELEASE; IN-VIVO; PANNEXIN-1 CHANNELS; ALZHEIMERS-DISEASE; CULTURED
MICROGLIA; RETINAL MICROGLIA; RESTING MICROGLIA; EXTRACELLULAR ATP; P2Y
RECEPTORS; MOUSE RETINA
AB Recent studies have indicated that constitutive functions of microglia in the healthy adult central nervous system (CNS) involve immune surveillance, synapse maintenance and trophic support. These functions have been related to the ramified structure of 'resting' microglia and the prominent motility in their processes that provide extensive coverage of the entire extracellular milleu. In this review, we examine how external signals, and in particular, ionotropic neurotransmission, regulate features of microglial morphology and process motility. Current findings indicate that microglial physiology in the healthy CNS is constitutively and reciprocally regulated by endogenous ionotropic glutamatergic and GABAergic neurotransmission. These influences do not act directly on microglial cells but indirectly via the activity-dependent release of ATP, likely through a mechanism involving pannexin channels. Microglia in the 'resting' state are not only dynamically active, but also constantly engaged in ongoing communication with neuronal and macroglial components of the CNS in a functionally relevant way.
C1 [Wong, Wai T.; Wang, Minhua] NEI, Unit Neuron Glia Interact Retinal Dis, NIH, Bethesda, MD 20892 USA.
[Li, Wei] NEI, Unit Retinal Neurophysiol, NIH, Bethesda, MD 20892 USA.
RP Wong, WT (reprint author), NEI, Unit Neuron Glia Interact Retinal Dis, NIH, 6 Ctr Dr,Room 217, Bethesda, MD 20892 USA.
EM wongw@nei.nih.gov
RI Wong, Wai/B-6118-2017
OI Wong, Wai/0000-0003-0681-4016
FU National Eye Institute Intramural Research Program
FX We thank Benjamin Chaon for helpful comments on the manuscript. This
work is supported by the National Eye Institute Intramural Research
Program.
NR 57
TC 10
Z9 10
U1 2
U2 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1740-925X
J9 NEURON GLIA BIOL
JI Neuron Glia Biol.
PY 2011
VL 7
IS 1
SI SI
BP 41
EP 46
DI 10.1017/S1740925X11000123
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 984FH
UT WOS:000307175000005
PM 22166726
ER
PT J
AU Wake, H
Moorhouse, AJ
Nabekura, J
AF Wake, Hiroaki
Moorhouse, Andrew J.
Nabekura, Junichi
TI Functions of microglia in the central nervous system - beyond the immune
response
SO NEURON GLIA BIOLOGY
LA English
DT Article
DE Microglia; synapse; synapse stripping
ID TUMOR-NECROSIS-FACTOR; SUBVENTRICULAR ZONE; NEURONAL DEATH; IN-VIVO;
HIPPOCAMPAL NEUROGENESIS; SYNAPTIC PLASTICITY; CELL-PROLIFERATION;
ALZHEIMERS-DISEASE; BRAIN-DEVELOPMENT; OLFACTORY-BULB
AB Microglia cells are the immune cells of the central nervous system and consequently play important roles in brain infections and inflammation. Recent in vivo imaging studies have revealed that in the resting healthy brain, microglia are highly dynamic, moving constantly to actively survey the brain parenchyma. These active microglia can rapidly respond to pathological insults, becoming activated to induce a range of effects that may contribute to both pathogenesis, or to confer neuronal protection. However, interactions between microglia and neurons are being recognized as important in shaping neural circuit activity under more normal, physiological conditions. During development and neurogenesis, microglia interactions with neurons help to shape the final patterns of neural circuits important for behavior and with implications for diseases. In the mature brain, microglia can respond to changes in sensory activity and can influence neuronal activity acutely and over the long term. Microglia seem to be particularly involved in monitoring the integrity of synaptic function. In this review, we discuss some of these new insights into the involvement of microglia in neural circuits.
C1 [Wake, Hiroaki] NICHHD, Nervous Syst Dev & Plast Sect, NIH, Bethesda, MD 20892 USA.
[Moorhouse, Andrew J.] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia.
[Nabekura, Junichi] Natl Inst Physiol Sci, Div Homeostat Dev, Okazaki, Aichi 444, Japan.
[Nabekura, Junichi] Grad Univ Adv Studies, Dept Physiol Sci, Hayama, Japan.
RP Wake, H (reprint author), NICHD, Nervous Syst Dev & Plast Sect, NIH, Bldg 35,Room 2A213,35 Lincoln Dr, Bethesda, MD 20892 USA.
EM wakeh@mail.nih.gov
RI Moorhouse, Andrew/B-8526-2011;
OI Moorhouse, Andrew/0000-0001-7957-2498
FU National Institute of Child Health and Human Development; Society for
the Promotion of Science fellowship
FX We gratefully acknowledge R. Douglas Fields and Olena Bukalo for
critical reading. This work was supported by the intramural research
program at the National Institute of Child Health and Human Development
and by a Japan Society for the Promotion of Science fellowship for H.
Wake.
NR 55
TC 27
Z9 27
U1 4
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1740-925X
J9 NEURON GLIA BIOL
JI Neuron Glia Biol.
PY 2011
VL 7
IS 1
SI SI
BP 47
EP 53
DI 10.1017/S1740925X12000063
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 984FH
UT WOS:000307175000006
PM 22613055
ER
PT J
AU Sy, MS
Altekruse, SF
Li, CY
Lynch, CF
Goodman, MT
Hernandez, BY
Zhou, L
Saber, MS
Hewitt, SM
Xin, W
AF Sy, Man-Sun
Altekruse, Sean F.
Li, Chaoyang
Lynch, Charles F.
Goodman, Marc T.
Hernandez, Brenda Y.
Zhou, Lan
Saber, Maria Sibug
Hewitt, Stephen M.
Xin, Wei
TI Association of prion protein expression with pancreatic adenocarcinoma
survival in the SEER residual tissue repository
SO CANCER BIOMARKERS
LA English
DT Article
DE Pancreas; adenocarcinoma; prion; prp; prognosis; immunohistochemistry;
biomarker
ID PRO-PRION; CANCER; PROGNOSIS; FILAMIN; BIOMARKERS; BINDING; MARKER
AB Pancreatic ductal adenocarcinoma (PDAC) is an important cause of cancer death with no clear prognostic biomarker. Expression of prion (PrP) has been reported to be a marker of poor prognosis in a series of Caucasian PDAC cases. We determined the prognostic value of PrP in a racially and geographically diverse population-based series of PDAC cases. PrP expression was examined in 142 PDAC cases from three cancer registries. Cases included 71 Caucasian, 54 Asian/Pacific Islanders and 17 Blacks diagnosed from 1983-2000, and followed through 2008. Hazard ratios (HR) and 95% confidence intervals (CIs) for the association of PrP expression with survival were computed after adjustment for case attributes. The risk of death was about four times higher (HR = 3.8; 95% CI: 2.2, 6.5) among 108 PDAC cases with PrP+ tumors (median survival 5 months) compared to the 34 cases with PrP- tumors (median survival 20 months). Of 51 cases with resected, localized PDAC median survival was 74 months for 17 cases with PrP- tumors versus 14 months for 34 cases with PrP+ tumors (HR = 6.7; 95% CI: 2.6, 17.4). All 6 surviving cases had PrP- negative tumors (median survival, > 10 years). PrP may have potential as a prognostic biomarker in PDAC patient management.
C1 [Xin, Wei] Univ Hosp Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA.
[Sy, Man-Sun; Li, Chaoyang; Zhou, Lan; Xin, Wei] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA.
[Altekruse, Sean F.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA.
[Goodman, Marc T.; Hernandez, Brenda Y.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
[Saber, Maria Sibug] USC Norris Comprehens Canc Ctr, Dept Pathol, Keck Sch Med, Los Angeles, CA USA.
[Saber, Maria Sibug] Hosp Los Angeles, Los Angeles, CA USA.
[Hewitt, Stephen M.] NCI, Tissue Array Res Program, Bethesda, MD 20892 USA.
RP Xin, W (reprint author), Univ Hosp Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA.
EM wxx10@case.edu
OI Hewitt, Stephen/0000-0001-8283-1788
FU Pathology Association of University Hospital of Cleveland Research
Grant; Department of Pathology of Case Western Reserve University; SEER
(Iowa) [NO1-PC-35143]; SEER (Hawaii) [NO1-PC-35137]; SEER (Los Angeles)
[NO1-PC-35139]
FX NIH R21CA133559-01 (M-S. S), by Pathology Association of University
Hospital of Cleveland Research Grant, and startup fund from Department
of Pathology of Case Western Reserve University (W. X.) Intramural
Research Program of the NIH, NCI, Center for Cancer Research (S. M. H.).
NCI contracts for the participating SEER Registries were NO1-PC-35143
(Iowa), NO1-PC-35137 (Hawaii) and NO1-PC-35139 (Los Angeles). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 16
TC 5
Z9 5
U1 2
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2011
VL 10
IS 6
BP 251
EP 258
DI 10.3233/CBM-2012-0256
PG 8
WC Oncology
SC Oncology
GA 977LY
UT WOS:000306664100001
PM 22820080
ER
PT J
AU Narfstrom, K
Deckman, KH
Menotti-Raymond, M
AF Narfstroem, Kristina
Deckman, Koren Holland
Menotti-Raymond, Marilyn
TI The Domestic Cat as a Large Animal Model for Characterization of Disease
and Therapeutic Intervention in Hereditary Retinal Blindness
SO JOURNAL OF OPHTHALMOLOGY
LA English
DT Review
ID ROD-CONE DYSPLASIA; LEBER CONGENITAL AMAUROSIS; GENOME-WIDE ASSOCIATION;
RETINITIS-PIGMENTOSA; ABYSSINIAN CATS; CENTROSOMAL PROTEIN; EARLY-ONSET;
NEURONAL DIFFERENTIATION; LINKAGE DISEQUILIBRIUM; JOUBERT-SYNDROME
AB Large mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, elucidation of disease mechanisms, and for development of therapeutic intervention. Two well-characterized feline models are addressed in this paper. The first model is the autosomal recessive, slowly progressive, late-onset, rod-cone degenerative disease caused by a mutation in the CEP290 gene. The second model addressed in this paper is the autosomal dominant early onset rod cone dysplasia, putatively caused by the mutation found in the CRX gene. Therapeutic trials have been performed mainly in the former type including stem cell therapy, retinal transplantation, and development of ocular prosthetics. Domestic cats, having large human-like eyes with comparable spontaneous retinal diseases, are also considered useful for gene replacement therapy, thus functioning as effective model systems for further research.
C1 [Narfstroem, Kristina] Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Mason Eye Inst, Columbia, MO 65211 USA.
[Narfstroem, Kristina] Univ Missouri, Mason Eye Inst, Dept Ophthalmol, Columbia, MO 65212 USA.
[Deckman, Koren Holland] Gettysburg Coll, Dept Chem, Gettysburg, PA 17325 USA.
[Menotti-Raymond, Marilyn] NCI, Lab Genom Div, Frederick, MD 21702 USA.
RP Narfstrom, K (reprint author), Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Mason Eye Inst, Columbia, MO 65211 USA.
EM narfstromk@missouri.edu
FU National Cancer Institute, National Institutes of Health [N01-CO-12400];
Lincy Foundation; Discovery Eye Foundation; Grousbeck Family Foundation
FX This paper has been funded in part with federal funds from the National
Cancer Institute, National Institutes of Health, under contract
N01-CO-12400. The authors would like to thank the Lincy Foundation, the
Discovery Eye Foundation and the Grousbeck Family Foundation for their
financial support. The content of this publication does not necessarily
reflect the views or policies of the Department of Health and Human
Services, nor does mention of trade names, commercial products, or
organizations imply endorsement by the US Government.
NR 75
TC 10
Z9 10
U1 1
U2 5
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 2090-004X
J9 J OPHTHALMOL
JI J. Ophthalmol.
PY 2011
AR 906943
DI 10.1155/2011/906943
PG 8
WC Medicine, Research & Experimental; Ophthalmology
SC Research & Experimental Medicine; Ophthalmology
GA 979BO
UT WOS:000306790100044
ER
PT S
AU Lim, PH
Bagci, U
Aras, O
Li, B
AF Lim, Poay Hoon
Bagci, Ulas
Aras, Omer
Li, Bai
GP IEEE
TI Identification of Spinal Vertebrae Using Mathematical Morphology and
Level Set Method
SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE
(NSS/MIC)
SE IEEE Nuclear Science Symposium Conference Record
LA English
DT Proceedings Paper
CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th
International Workshop on Room-Temperature Semiconductor X-Ray and
Gamma-Ray Detectors
CY OCT 23-29, 2011
CL Valencia, SPAIN
SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS)
AB Precise detection and segmentation of spinal vertebrae are crucial in the study of spinal related disease or disorders such as vertebral fractures. Identifying severity of fractures and understanding its causes will help physicians determine the most effective pharmacological treatments and clinical management strategies for spinal disorders. Although image segmentation has been a widely research area, limited work has been done on detecting and segmenting vertebrae. The complexity of vertebrae shapes, gaps in the cortical bone, internal boundaries, as well as the noisy, incomplete or missing information from the medical images have undoubtedly increased the challenge. In this paper, we introduce a new, mathematically driven spinal vertebrae segmentation framework. We first use the traditional image processing techniques, the mathematical morphology and curve fitting to identify the spinal vertebrae and connect them through their centroid. This process is followed by an advanced shape driven level set segmentation, where the level set evolution is guided by a shape constraint and driven by a shape energy coupled with a Gaussian kernel. Experimental results on CT images of spinal vertebrae demonstrate the feasibility of our proposed framework. Our ultimate goal is to provide a quantitative platform for efficient and accurate diagnosis of spinal disorder related diseases.
C1 [Lim, Poay Hoon; Li, Bai] Univ Nottingham, Sch Comp Sci, Nottingham NG8 1BB, England.
[Bagci, Ulas] NIH, Bethesda, MD 20892 USA.
[Aras, Omer] NCI, Mol Imaging Ctr, Bethesda, MD 20892 USA.
RP Lim, PH (reprint author), Univ Nottingham, Sch Comp Sci, Nottingham NG8 1BB, England.
EM phl@cs.nott.ac.uk; ulas.bagci@nih.gov; dromeraras@gmail.com;
bai@cs.nott.ac.uk
NR 8
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1082-3654
BN 978-1-4673-0120-6
J9 IEEE NUCL SCI CONF R
PY 2011
BP 3105
EP 3107
PG 3
WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science
& Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Physics; Imaging Science & Photographic Technology;
Radiology, Nuclear Medicine & Medical Imaging
GA BAM64
UT WOS:000304755603075
ER
PT J
AU Dzik, WH
Blajchman, MA
Fergusson, D
Hameed, M
Henry, B
Kirkpatrick, AW
Korogyi, T
Logsetty, S
Skeate, RC
Stanworth, S
MacAdams, C
Muirhead, B
AF Dzik, Walter H.
Blajchman, Morris A.
Fergusson, Dean
Hameed, Morad
Henry, Blair
Kirkpatrick, Andrew W.
Korogyi, Teresa
Logsetty, Sarvesh
Skeate, Robert C.
Stanworth, Simon
MacAdams, Charles
Muirhead, Brian
TI Clinical review: Canadian National Advisory Committee on Blood and Blood
Products - Massive Transfusion Consensus Conference 2011: report of the
panel
SO CRITICAL CARE
LA English
DT Review
ID FRESH-FROZEN PLASMA; RESPIRATORY-DISTRESS-SYNDROME; BLEEDING TRAUMA
PATIENTS; MAJOR TRAUMA; COAGULATION ABNORMALITIES; INTRACEREBRAL
HEMORRHAGE; ACUTE COAGULOPATHY; CELL TRANSFUSION; PROTHROMBIN TIME;
CONTROLLED-TRIAL
AB In June 2011 the Canadian National Advisory Committee on Blood and Blood Products sponsored an international consensus conference on transfusion and trauma. A panel of 10 experts and two external advisors reviewed the current medical literature and information presented at the conference by invited international speakers and attendees. The Consensus Panel addressed six specific questions on the topic of blood transfusion in trauma. The questions focused on: ratio-based blood resuscitation in trauma patients; the impact of survivorship bias in current research conclusions; the value of nonplasma coagulation products; the role of protocols for delivery of urgent transfusion; the merits of traditional laboratory monitoring compared with measures of clot viscoelasticity; and opportunities for future research. Key findings include a lack of evidence to support the use of 1:1:1 blood component ratios as the standard of care, the importance of early use of tranexamic acid, the expected value of an organized response plan, and the recommendation for an integrated approach that includes antifibrinolytics, rapid release of red blood cells, and a foundation ratio of blood components adjusted by results from either traditional coagulation tests or clot viscoelasticity or both. The present report is intended to provide guidance to practitioners, hospitals, and policy-makers.
C1 [Dzik, Walter H.] Massachusetts Gen Hosp, Blood Transfus Serv, Boston, MA 02114 USA.
[Blajchman, Morris A.] McMaster Univ, Med Ctr, Dept Pathol, Canadian Blood Serv, Hamilton, ON L8N 3Z5, Canada.
[Blajchman, Morris A.] McMaster Univ, Med Ctr, Dept Med, Canadian Blood Serv, Hamilton, ON L8N 3Z5, Canada.
[Blajchman, Morris A.] NHLBI TMH Clin Trials Network, Bethesda, MD USA.
[Fergusson, Dean] Univ Ottawa, Ottawa Hosp Res Inst, Fac Med, Dept Clin Epidemiol,Clin Epidemiol Program, Ottawa, ON K1H 8L6, Canada.
[Hameed, Morad] Univ British Columbia, Vancouver Gen Hosp, Dept Surg & Crit Care Med, Trauma Serv,Gen Surg Residency Program, Vancouver, BC V5Z 1M9, Canada.
[Henry, Blair] Univ Toronto, Sunnybrook Hlth Sci Ctr, Joint Ctr Bioeth, Sunnybrook Hlth Sci Ctr,Dept Family & Community M, Toronto, ON M4N 3M5, Canada.
[Kirkpatrick, Andrew W.] Univ Calgary, Foothills Med Ctr, Dept Crit Care Med & Surg, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada.
[Korogyi, Teresa] Sunnybrook Hlth Sci Ctr, Emergency Dept, Toronto, ON M4N 3M5, Canada.
[Logsetty, Sarvesh] Univ Manitoba, Manitoba Firefighters Burn Unit, Winnipeg, MB R3A 1R9, Canada.
[Skeate, Robert C.] Univ Toronto, Dept Lab Med & Pathobiol, Canadian Blood Serv Cent Ontario Reg, Toronto, ON M5G 2M1, Canada.
[Stanworth, Simon] Univ Oxford, John Radcliffe Hosp, Dept Haematol, Oxford OX3 9DU, England.
[MacAdams, Charles] Foothills Med Ctr, Dept Anesthesia, Perioperat Blood Conservat Program Calgary Zone, Calgary, AB T2N 2T9, Canada.
[Muirhead, Brian] Univ Manitoba, Dept Anesthesiol, Blood Conservat Serv, Transfus Practices Comm, Winnipeg, MB R3M 3E8, Canada.
RP Dzik, WH (reprint author), Massachusetts Gen Hosp, Blood Transfus Serv, 55 Fruit St, Boston, MA 02114 USA.
EM sdzik@partners.org
FU Canadian National Advisory Committee on Blood and Blood Products
FX The Canadian National Advisory Committee on Blood and Blood Products
provided funding. The authors wish to acknowledge the Planning Committee
of the Massive Transfusion Consensus Conference who organized the
meeting, formulated the questions to the panel, and invited the speakers
who presented data at the meeting. The planning committee members were:
Sandro Rizoli (chairman) (Sunnybrook Health Sciences Centre, Toronto,
Canada); Jeannie Callum (Sunnybrook Health Sciences Centre, Toronto,
Canada); Cheryl Doncaster (Department of Health and Community Services,
Newfoundland and Labrador, Canada); David Howe (Canadian Blood Services,
Ottawa, Canada); Catherine Moltzan (Winnipeg Regional Health Authority,
Winnipeg, Canada); Susan Nahirniak (University of Alberta Hospital,
Edmonton, Canada); Bartolomeu Nascimento (Sunnybrook Health Sciences
Centre, Toronto, Canada); Katerina Pavenski (St Michael's Hospital,
Toronto, Canada); Homer Tien (Sunnybrook Health Sciences Centre,
Toronto, Canada); and Lucinda Whitman (Eastern Health, Newfoundland and
Labrador, Canada).
NR 97
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Z9 67
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
J9 CRIT CARE
JI Crit. Care
PY 2011
VL 15
IS 6
AR 242
DI 10.1186/cc10498
PG 12
WC Critical Care Medicine
SC General & Internal Medicine
GA 969VJ
UT WOS:000306087200009
PM 22188866
ER
PT J
AU Han, SH
Martin, GS
Maloney, JP
Shanholtz, C
Barnes, KC
Murray, S
Sevransky, JE
AF Han, SeungHye
Martin, Greg S.
Maloney, James P.
Shanholtz, Carl
Barnes, Kathleen C.
Murray, Stacey
Sevransky, Jonathan E.
TI Short women with severe sepsis-related acute lung injury receive lung
protective ventilation less frequently: an observational cohort study
SO CRITICAL CARE
LA English
DT Article
ID RESPIRATORY-DISTRESS-SYNDROME; CRITICALLY-ILL PATIENTS; MECHANICAL
VENTILATION; MYOCARDIAL-INFARCTION; CONSENSUS CONFERENCE;
TRAUMA-HEMORRHAGE; INTENSIVE-CARE; CLINICAL-TRIAL; UNITED-STATES; GENDER
AB Introduction: Lung protective ventilation (LPV) has been shown to improve survival and the duration of mechanical ventilation in acute lung injury (ALI) patients. Mortality of ALI may vary by gender, which could result from treatment variability. Whether gender is associated with the use of LPV is not known.
Methods: A total of 421 severe sepsis-related ALI subjects in the Consortium to Evaluate Lung Edema Genetics from seven teaching hospitals between 2002 and 2008 were included in our study. We evaluated patients' tidal volume, plateau pressure and arterial pH to determine whether patients received LPV during the first two days after developing ALI. The odds ratio of receiving LPV was estimated by a logistic regression model with robust and cluster options.
Results: Women had similar characteristics as men with the exception of lower height and higher illness severity, as measured by Acute Physiology and Chronic Health Evaluation (APACHE) II score. 225 (53%) of the subjects received LPV during the first two days after ALI onset; women received LPV less frequently than men (46% versus 59%, P < 0.001). However, after adjustment for height and severity of illness (APACHE II), there was no difference in exposure to LPV between men and women (P = 0.262).
Conclusions: Short people are less likely to receive LPV, which seems to explain the tendency of clinicians to adhere to LPV less strictly in women. Strategies to standardize application of LPV, independent of differences in height and severity of illness, are necessary.
C1 [Han, SeungHye] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
[Martin, Greg S.] Emory Univ, Div Pulm Allergy & Crit Care, Atlanta, GA 30303 USA.
[Maloney, James P.] Univ Colorado, Div Pulm Sci & Crit Care Med, Denver, CO 80262 USA.
[Shanholtz, Carl] Univ Maryland, Div Pulm & Crit Care, Baltimore, MD 21201 USA.
[Barnes, Kathleen C.] Johns Hopkins Univ, Div Allergy & Clin Immunol, Baltimore, MD 21224 USA.
[Murray, Stacey; Sevransky, Jonathan E.] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA.
RP Han, SH (reprint author), NIH, Dept Crit Care Med, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM shan@jhsph.edu
RI maloney, james/K-9428-2015;
OI maloney, james/0000-0001-8348-4650; Shanholtz, Carl/0000-0003-3938-178X;
Martin, Greg/0000-0002-9684-7593
FU National Heart, Blood, and Lung Institute Specialized Centers of
Clinically Oriented Research (SCCOR) [P050 HL]; National Institutes of
Health [K-23 GMO7-1399]; Mary Beryl Patch Turnbull Scholar Program
FX The authors are grateful to all the study coordinators for recruitment
of subjects into the Consortium to Evaluate Lung Edema Genetics (CELEG).
This research was supported by a National Heart, Blood, and Lung
Institute Specialized Centers of Clinically Oriented Research (SCCOR)
grant in Acute Lung Injury SCCOR grant P050 HL. JES is supported by
National Institutes of Health K-23 GMO7-1399. KCB is supported by Mary
Beryl Patch Turnbull Scholar Program.
NR 33
TC 18
Z9 18
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
J9 CRIT CARE
JI Crit. Care
PY 2011
VL 15
IS 6
AR R262
DI 10.1186/cc10524
PG 8
WC Critical Care Medicine
SC General & Internal Medicine
GA 969VJ
UT WOS:000306087200056
PM 22044724
ER
PT J
AU Mikami, K
Suzuki, M
Kitagawa, H
Kawakami, M
Hirota, N
Shimbara-Mikami, A
Sakamoto, Y
AF Mikami, Katsunaka
Suzuki, Masaru
Kitagawa, Hiroshi
Kawakami, Masaki
Hirota, Nobuaki
Shimbara-Mikami, Ayako
Sakamoto, Yoshio
TI Severity of community-acquired pneumonia treated with low-dose
adjunctive corticosteroid
SO CRITICAL CARE
LA English
DT Letter
C1 [Suzuki, Masaru; Kawakami, Masaki; Sakamoto, Yoshio] Kanto Cent Hosp, Dept Internal Med, Setagaya Ku, Tokyo 1588531, Japan.
[Mikami, Katsunaka] Tokai Univ, Sch Med, Dept Psychiat, Isehara, Kanagawa 2591193, Japan.
[Kitagawa, Hiroshi] NCI, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA.
[Hirota, Nobuaki] McGill Univ, Dept Med, Meakins Christie Labs, Montreal, PQ, Canada.
[Shimbara-Mikami, Ayako] Tokai Univ, Sch Med, Dept Clin Pharmacol, Isehara, Kanagawa 2591193, Japan.
RP Suzuki, M (reprint author), Kanto Cent Hosp, Dept Internal Med, Setagaya Ku, 6-25-1 Kamiyoga, Tokyo 1588531, Japan.
EM masaruszk@aol.com
NR 0
TC 0
Z9 0
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
J9 CRIT CARE
JI Crit. Care
PY 2011
VL 15
IS 6
AR 451
DI 10.1186/cc10500
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA 969VJ
UT WOS:000306087200019
PM 22071207
ER
PT S
AU Sun, Y
Haseltine, F
Cork, J
Lockett, E
Chang, F
Chen, L
AF Sun, Ying
Haseltine, Florence
Cork, John
Lockett, Elizabeth
Chang, Florence
Chen, Lucie
BE Xing, CX
Crestani, F
Rauber, A
TI Embryo App for iPhone/iPad/iPod Touch
SO DIGITAL LIBRARIES: FOR CULTURAL HERITAGE, KNOWLEDGE DISSEMINATION, AND
FUTURE CREATION: ICADL 2011
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 13th International Conference on Asia-Pacific Digital Libraries (ICADL
2011)
CY OCT 24-27, 2011
CL Tsinghua Univ, Beijing, PEOPLES R CHINA
SP Peking Univ, Natl Lib China
HO Tsinghua Univ
DE Mobile app; iPhone; database; Embryo; 2D images; 3D animations
AB Scientists and educators worldwide use the Carnegie Collection of Embryology to define normal human embryo development for decades. The Embryo App for iPhone/iPad and iPod Touch, developed by National Library of Medicine (NLM), utilizes mobile telecommunication and multimedia technologies to add interactive capabilities to the embryo data, enhancing our understanding of embryo development. Embryo is a collaborative project between NLM, the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), Louisiana State University Health Sciences Center (LSUHSC) and National Museum of Health & Medicine's Human Developmental Anatomy Center (NMHM & HDAC). This App is part of the National Library of Medicine's program to fulfill the NLM's role as a provider of medical, science and health care information with mobile technologies. The Embryo App provides a new venue for us to access and interact with the Carnegie Collection of Embryology for the first time.
C1 [Sun, Ying; Chang, Florence; Chen, Lucie] NIH, Natl Lib Med, 6707 Democracy Blvd Suite 510, Bethesda, MD 20892 USA.
[Haseltine, Florence] NICHHD, Rockville, MD USA.
[Cork, John] Louisiana State Univ Hlth Sci Ctr, New Orleans, LA USA.
[Lockett, Elizabeth] Natl Museum Hlth & Med, Silver Spring, MD USA.
RP Sun, Y (reprint author), NIH, Natl Lib Med, 6707 Democracy Blvd Suite 510, Bethesda, MD 20892 USA.
EM yingsun@mail.nih.gov
NR 0
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24825-2
J9 LECT NOTES COMPUT SC
PY 2011
VL 7008
BP 377
EP +
PG 2
WC Computer Science, Information Systems; Computer Science, Theory &
Methods; Information Science & Library Science
SC Computer Science; Information Science & Library Science
GA BBA17
UT WOS:000306259000048
ER
PT J
AU Dillon, DG
Deveney, CM
Pizzagalli, DA
AF Dillon, Daniel G.
Deveney, Christen M.
Pizzagalli, Diego A.
TI From Basic Processes to Real-World Problems: How Research on Emotion and
Emotion Regulation Can Inform Understanding of Psychopathology, and Vice
Versa
SO EMOTION REVIEW
LA English
DT Article
DE affective neuroscience; emotion; emotion regulation; fear;
psychopathology; reward
ID FEAR-POTENTIATED STARTLE; SOCIAL ANXIETY DISORDER; MAJOR DEPRESSION;
D-CYCLOSERINE; CONDITIONED FEAR; PANIC DISORDER; EXPOSURE THERAPY;
NEGATIVE EMOTION; AFFECTIVE NEUROSCIENCE; INDIVIDUAL-DIFFERENCES
AB Research on emotion and emotion regulation is expected to improve our understanding of psychopathology. However, achieving this understanding requires overcoming several obstacles, including the paucity of objective markers of specific emotions or psychiatric diagnoses, and the fact that emotion regulation is a concept that can be difficult to operationalize. We review affective neuroscience research that has addressed these issues by focusing on psychological and neural mechanisms implicated in approach and avoidance behaviors, as revealed by studies of fear, anxiety, and reward processing. Dysfunction in these mechanisms may serve as risk markers for psychopathology, while emotion regulation research demonstrates that some of them are susceptible to volitional control. The conclusion acknowledges limitations of affective neuroscience and highlights goals for future work.
C1 [Dillon, Daniel G.; Pizzagalli, Diego A.] Harvard Univ, McLean Hosp, Sch Med, Ctr Depress Stress & Anxiety Res, Belmont, MA 02478 USA.
[Deveney, Christen M.] NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA.
RP Dillon, DG (reprint author), Harvard Univ, McLean Hosp, Sch Med, Ctr Depress Stress & Anxiety Res, 233B deMarneffe Bldg,115 Mill St, Belmont, MA 02478 USA.
EM dillon@wjh.harvard.edu
OI Dillon, Daniel/0000-0002-1977-700X
FU NCCIH NIH HHS [R21 AT002974, R21 AT002974-01A1, R21 AT002974-02]; NIMH
NIH HHS [F32 MH081394, F32 MH081394-01A2, F32 MH081394-02, R01 MH068376,
R01 MH068376-01A1, R01 MH068376-02, R01 MH068376-03, R01 MH068376-04,
R01 MH068376-05, R01 MH068376-06A1, R21 MH078979, R21 MH078979-01A2, R21
MH078979-02]
NR 88
TC 15
Z9 15
U1 11
U2 28
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1754-0739
J9 EMOT REV
JI Emot. Rev.
PD JAN
PY 2011
VL 3
IS 1
BP 74
EP 82
DI 10.1177/1754073910380973
PG 9
WC Psychology, Multidisciplinary
SC Psychology
GA 972IT
UT WOS:000306271500009
PM 21584224
ER
PT B
AU Paik, SJ
AF Paik, Susan J.
BE Redding, S
Murphy, M
Sheley, P
TI Minority Families and Schooling
SO HANDBOOK ON FAMILY AND COMMUNITY ENGAGEMENT
LA English
DT Article; Book Chapter
C1 [Paik, Susan J.] Claremont Grad Univ, Sch Educ, Urban Leadership Program, Claremont, CA USA.
[Paik, Susan J.] NIMH, Bethesda, MD USA.
RP Paik, SJ (reprint author), Claremont Grad Univ, Sch Educ, Urban Leadership Program, Claremont, CA USA.
NR 25
TC 0
Z9 0
U1 0
U2 2
PU INFORMATION AGE PUBLISHING-IAP
PI CHARLOTTE
PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA
BN 978-1-61735-668-1
PY 2011
BP 121
EP 124
PG 4
WC Education & Educational Research; Family Studies
SC Education & Educational Research; Family Studies
GA BAC13
UT WOS:000303779400025
ER
PT S
AU Yang, X
Lauzon, CB
Crainiceanu, C
Caffo, B
Resnick, SM
Landman, BA
AF Yang, Xue
Lauzon, Carolyn B.
Crainiceanu, Ciprian
Caffo, Brian
Resnick, Susan M.
Landman, Bennett A.
BE Liu, T
Shen, D
Ibanez, L
Tao, X
TI Accounting for Random Regressors: A Unified Approach to Multi-modality
Imaging
SO MULTIMODAL BRAIN IMAGE ANALYSIS
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 1st International Workshop on Multimodal Brain Image Analysis (MBIA
2011)
CY SEP 18, 2011
CL Toronto, CANADA
DE Model II regression; Inference; Statistical parametric mapping;
Biological parametric mapping; model fitting
AB Massively univariate regression and inference in the form of statistical parametric mapping have transformed the way in which multidimensional imaging data are studied. In functional and structural neuroimaging, the de facto standard "design matrix"-based general linear regression model and its multi-level cousins have enabled investigation of the biological basis of the human brain. With modern study designs, it is possible to acquire multiple three-dimensional assessments of the same individuals e.g., structural, functional and quantitative magnetic resonance imaging alongside functional and ligand binding maps with positron emission tomography. Current statistical methods assume that the regressors are non-random. For more realistic multi-parametric assessment (e.g., voxel-wise modeling), distributional consideration of all observations is appropriate (e.g., Model II regression). Herein, we describe a unified regression and inference approach using the design matrix paradigm which accounts for both random and non-random imaging regressors.
C1 [Yang, Xue; Lauzon, Carolyn B.; Landman, Bennett A.] Vanderbilt Univ, Elect Engn, 221 Kirkland Hall, Nashville, TN 37235 USA.
[Crainiceanu, Ciprian; Caffo, Brian] Johns Hopkins Univ, Dept Biostat, Baltimore, MD USA.
[Resnick, Susan M.] NIH, NIA, Baltimore, MD USA.
RP Yang, X (reprint author), Vanderbilt Univ, Elect Engn, 221 Kirkland Hall, Nashville, TN 37235 USA.
EM Xue.Yang@vanderbilt.edu; Carolyn.Lauzon@vanderbilt.edu;
ccrainic@jhsph.edu; bcaffo@jhsph.edu; resnicks@grc.nia.nih.gov;
Bennett.Landman@vanderbilt.edu
FU NIH [N01-AG-4-0012]
FX This project was supported by NIH N01-AG-4-0012. This work described
herein has not been submitted elsewhere for publication.
NR 11
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24445-2
J9 LECT NOTES COMPUT SC
PY 2011
VL 7012
BP 1
EP +
PG 3
WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine &
Medical Imaging
SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging
GA BBB49
UT WOS:000306341700001
ER
PT J
AU Andrade, LR
Manor, U
Kachar, B
AF Andrade, L. R.
Manor, U.
Kachar, B.
TI Adult hair cell stereocilia actin cores undergo dynamic renewal.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Andrade, L. R.; Manor, U.; Kachar, B.] NIDCD, NIH, Bethesda, MD USA.
[Andrade, L. R.] Univ Fed Rio de Janeiro, Inst Biomed Sci, Rio De Janeiro, Brazil.
RI Andrade, Leonardo/C-9554-2011
OI Andrade, Leonardo/0000-0002-0004-5677
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1404
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502517
ER
PT J
AU Brownlee, CW
Klebba, JE
Buster, DW
Rusan, NM
Rogers, GC
AF Brownlee, C. W.
Klebba, J. E.
Buster, D. W.
Rusan, N. M.
Rogers, G. C.
TI SV40 small tumor antigen exploits PP2A's role in stabilizing Plk4 to
induce centriole amplification.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Brownlee, C. W.; Klebba, J. E.; Buster, D. W.; Rogers, G. C.] Univ Arizona, Tucson, AZ USA.
[Rusan, N. M.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 893
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502011
ER
PT J
AU Burnette, D
Sengupta, P
Dai, Y
Lippincott-Schwartz, J
Kachar, B
AF Burnette, D.
Sengupta, P.
Dai, Y.
Lippincott-Schwartz, J.
Kachar, B.
TI Bleaching/blinking assisted localization microscopy (BALM) for
super-resolution imaging using standard fluorescent molecules
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Burnette, D.; Sengupta, P.; Lippincott-Schwartz, J.] NICHHD, CBMB, NIH, Bethesda, MD 20892 USA.
[Dai, Y.; Kachar, B.] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 62
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500063
ER
PT J
AU Case, C
Wangsa, D
Sackett, D
Ried, T
Camps, J
AF Case, C.
Wangsa, D.
Sackett, D.
Ried, T.
Camps, J.
TI Depletion of Spindle Pole Protein, CKAP2, Increases Chromosomal
Instability in Colorectal Cancer Cells.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Case, C.; Wangsa, D.; Ried, T.; Camps, J.] NCI, NIH, Bethesda, MD 20892 USA.
[Case, C.] George Washington Univ, Inst Biomed Sci, Washington, DC USA.
[Sackett, D.] NICHHD, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1430
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503018
ER
PT J
AU Chen, WC
Heim, E
Hale, CM
Lee, JS
Wirtz, D
AF Chen, W-C.
Heim, E.
Hale, C. M.
Lee, J. S.
Wirtz, D.
TI Distinctive Cell Polarization Mechanisms Depend on Cell Shape and
Cell-Cell Contacts.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Chen, W-C.; Hale, C. M.; Lee, J. S.; Wirtz, D.] Johns Hopkins Univ, Baltimore, MD USA.
[Chen, W-C.; Hale, C. M.; Wirtz, D.] Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD USA.
[Lee, J. S.] NCI, Ctr Strateg Sci Initiat, Bethesda, MD 20892 USA.
[Heim, E.] Univ Florida, Gainesville, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 647
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501200
ER
PT J
AU Chow, KH
Elgort, S
Dasso, M
Ullman, K
AF Chow, K-H.
Elgort, S.
Dasso, M.
Ullman, K.
TI The SUMO proteases SENP1 and SENP2 bind to Nup153 and control a cycle of
SUMO modification of this nucleoporin.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Chow, K-H.; Elgort, S.; Ullman, K.] Univ Utah, Salt Lake City, UT USA.
[Dasso, M.] Natl Inst Hlth, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 476
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501029
ER
PT J
AU Dobrinskikh, E
Okamura, K
Kopp, J
Blaine, J
Doctor, RB
AF Dobrinskikh, E.
Okamura, K.
Kopp, J.
Blaine, J.
Doctor, R. B.
TI Shank2 traffics with albumin-laden endosomes in human podocytes.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Dobrinskikh, E.; Okamura, K.; Blaine, J.; Doctor, R. B.] Univ Colorado, Dept Med, Aurora, CO USA.
[Kopp, J.] NIDDK, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 451
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501004
ER
PT J
AU Eckley, DM
Rahimi, S
Orlov, NV
Mantilla, S
Coletta, CE
Delaney, JD
Zhang, Y
Becker, K
Iser, W
Wilson, M
Goldberg, IG
AF Eckley, D. M.
Rahimi, S.
Orlov, N. V.
Mantilla, S.
Coletta, C. E.
Delaney, J. D.
Zhang, Y.
Becker, K.
Iser, W.
Wilson, M.
Goldberg, I. G.
TI Two distinguishable aging states found in an isogenic population at a
single chronological age.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Eckley, D. M.; Rahimi, S.; Orlov, N. V.; Mantilla, S.; Coletta, C. E.; Delaney, J. D.; Goldberg, I. G.] NIA, IICBU, Genet Lab, NIH, Baltimore, MD 21224 USA.
[Zhang, Y.; Becker, K.] NIA, Res Resources Branch, Intramural Res Program, Baltimore, MD 21224 USA.
[Iser, W.; Wilson, M.] NIA, IMGU, Neurosci Lab, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 2297
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505504326
ER
PT J
AU Elia, N
Fabrikant, G
Lippincoot-Schwartz, J
Kozlov, MM
AF Elia, N.
Fabrikant, G.
Lippincoot-Schwartz, J.
Kozlov, M. M.
TI Mechanistic model for ESCRT mediated cytokinetic abscission
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Elia, N.; Lippincoot-Schwartz, J.] NICHD, NIH, Bethesda, MD USA.
[Fabrikant, G.; Kozlov, M. M.] Tel Aviv Univ, Sch Med, Dept Physiol & Pharmacol, Tel Aviv, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 530
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501083
ER
PT J
AU Eromobor, I
Petrie, RJ
Gutierrez, N
Yamada, KM
Rodriguez, AJ
AF Eromobor, I.
Petrie, R. J.
Gutierrez, N.
Yamada, K. M.
Rodriguez, A. J.
TI Epithelial Contact Expansion Requires de novo mRNA Translation
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Eromobor, I.; Gutierrez, N.; Rodriguez, A. J.] Rutgers State Univ, Newark, NJ 07102 USA.
[Petrie, R. J.; Yamada, K. M.] NIDCR, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1575
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503160
ER
PT J
AU Fischer, RS
Elliott, HS
Waterman, CM
Danuser, G
AF Fischer, R. S.
Elliott, H. S.
Waterman, C. M.
Danuser, G.
TI Automated Surface Tracking and Morphodynamics Quantification of
Endothelial Cells in 3D Gels
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Fischer, R. S.; Waterman, C. M.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Elliott, H. S.; Danuser, G.] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 932
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502050
ER
PT J
AU Fu, D
Mitra, K
Sengupta, P
Lippincott-Schwartz, J
Arias, I
AF Fu, D.
Mitra, K.
Sengupta, P.
Lippincott-Schwartz, J.
Arias, I.
TI Mitochondrial fusion regulates hepatocyte polarization.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Fu, D.; Sengupta, P.; Lippincott-Schwartz, J.] NICHD, NIH, Bethesda, MD USA.
[Mitra, K.; Arias, I.] NHLBI, NIH, Bethesda, MD 20892 USA.
RI Fu, Dong /J-1426-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1303
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502417
ER
PT J
AU Giovinazzi, S
Morozov, V
Reinhold, WC
Ishov, AM
AF Giovinazzi, S.
Morozov, V.
Reinhold, W. C.
Ishov, A. M.
TI Daxx and USP7: novel regulators of genomic stability, mitosis and
taxanes sensitivity
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Reinhold, W. C.] NCI, Genom & Bioinformat Grp, NIH, Bethesda, MD 20892 USA.
[Ishov, A. M.] Univ Florida, Shands Canc Ctr, Gainesville, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 2269
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505504298
ER
PT J
AU Gudheti, MV
Gould, TJ
Kim, D
Curthoys, NM
Gabor, KA
Gunewardene, MS
Verkhusha, VV
Zimmerberg, J
Gosse, JA
Kim, CH
Hess, ST
AF Gudheti, M. V.
Gould, T. J.
Kim, D.
Curthoys, N. M.
Gabor, K. A.
Gunewardene, M. S.
Verkhusha, V. V.
Zimmerberg, J.
Gosse, J. A.
Kim, C. H.
Hess, S. T.
TI Cofilin is Excluded from Clusters of Influenza Hemagglutinin at the Host
Cell Membrane.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Gudheti, M. V.; Gould, T. J.; Kim, D.; Curthoys, N. M.; Gabor, K. A.; Gunewardene, M. S.; Gosse, J. A.; Kim, C. H.; Hess, S. T.] Univ Maine, Orono, ME USA.
[Verkhusha, V. V.] Yeshiva Univ, Albert Einstein Coll Med, New York, NY 10033 USA.
[Zimmerberg, J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1409
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502522
ER
PT J
AU Hayakawa, EH
Tokumasu, F
Usukura, J
Tuboi, T
Matsuoka, H
Wellems, TE
AF Hayakawa, E. H.
Tokumasu, F.
Usukura, J.
Tuboi, T.
Matsuoka, H.
Wellems, T. E.
TI Stereoscopic transmission electron microscopy of Maurer's Clefts in
"unroofed" specimens of Plasmodium falciparum-infected erythrocytes
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Hayakawa, E. H.; Matsuoka, H.] Jichi Med Univ, Lab Med Zool & Parasitol, Dept Infect & Immun, Shimotsuke, Japan.
[Tokumasu, F.; Wellems, T. E.] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA.
[Usukura, J.] Nagoya Univ, EcoTopia Sci Inst, Div Integrated Project, Nagoya, Aichi 4648601, Japan.
[Tuboi, T.] Ehime Univ, Cell Free Sci & Technol Res Ctr, Malaria Res Unit, Matsuyama, Ehime, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 764
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501317
ER
PT J
AU Hendrix, A
Westbroek, W
De Wever, O
AF Hendrix, A.
Westbroek, W.
De Wever, O.
TI The small GTPase Rab27B regulates invasive tumor growth and metastasis
through extracellular HSP90 alpha.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Hendrix, A.; De Wever, O.] Univ Ghent, B-9000 Ghent, Belgium.
[Westbroek, W.] NIH, Bethesda, MD 20892 USA.
RI de wever, olivier/J-3094-2013
OI de wever, olivier/0000-0002-5453-760X
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1612
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503197
ER
PT J
AU Hinshaw, JE
Chappie, JS
Mears, JA
Fang, S
Leonard, M
Heymann, JA
Schmid, SL
Milligan, RA
Dyda, F
AF Hinshaw, J. E.
Chappie, J. S.
Mears, J. A.
Fang, S.
Leonard, M.
Heymann, J. A.
Schmid, S. L.
Milligan, R. A.
Dyda, F.
TI Dynamin's powerstroke.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Hinshaw, J. E.; Chappie, J. S.; Fang, S.] NIH, Bethesda, MD 20892 USA.
[Mears, J. A.; Heymann, J. A.; Dyda, F.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
[Leonard, M.] Scripps Res Inst, La Jolla, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1031
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502147
ER
PT J
AU Horn, H
Dror, A
Roux, K
Kozlov, S
Avraham, K
Burke, B
Stewart, C
AF Horn, H.
Dror, A.
Roux, K.
Kozlov, S.
Avraham, K.
Burke, B.
Stewart, C.
TI The KASH Domain Protein Nesprin 4 is essential for cochlear outer hair
cell maintenance and hearing
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Horn, H.; Burke, B.; Stewart, C.] Inst Med Biol, Singapore, Singapore.
[Dror, A.; Avraham, K.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel.
[Roux, K.] Sanford Childrens Hlth Res Ctr, Sioux Falls, SD USA.
[Kozlov, S.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 49
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500050
ER
PT J
AU Joseph-Strauss, D
Gorjanacz, M
Voronina, E
Audhya, A
Cohen-Fix, O
AF Joseph-Strauss, D.
Gorjanacz, M.
Voronina, E.
Audhya, A.
Cohen-Fix, O.
TI Sm protein down-regulation leads to defects in nuclear pore complex
disassembly and distribution in C. elegans embryos.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Joseph-Strauss, D.] NIH, Bethesda, MD 20892 USA.
[Gorjanacz, M.] European Mol Biol Lab, Heidelberg, Germany.
[Voronina, E.] Johns Hopkins Sch Med, Baltimore, MD USA.
[Audhya, A.] Univ Wisconsin Madison Med Sch, Madison, WI USA.
[Cohen-Fix, O.] NIDDK NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 488
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501041
ER
PT J
AU Karuri, NW
Karuri, S
Kshatriya, P
AF Karuri, N. W.
Karuri, S.
Kshatriya, P.
TI Optimization of cell adhesion, cell spreading and extracellular matrix
assembly on mixtures of immobilized fibronectin domains.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Karuri, N. W.; Kshatriya, P.] IIT, Chicago, IL 60616 USA.
[Karuri, S.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1596
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503181
ER
PT J
AU Kim, Y
Sharov, A
Mcdole, K
Cheng, M
Hao, H
Fan, CM
Gaiano, N
Ko, M
Zheng, Y
AF Kim, Y.
Sharov, A.
Mcdole, K.
Cheng, M.
Hao, H.
Fan, C-M.
Gaiano, N.
Ko, M.
Zheng, Y.
TI B-type lamins regulates neither their bound genes nor embryonic stem
cells but are essential for organogenesis
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Kim, Y.; Mcdole, K.; Fan, C-M.; Zheng, Y.] Carnegie Inst Sci, Baltimore, MD USA.
[Sharov, A.; Ko, M.] NIA, Dev Genom & Aging Sect, NIH, Baltimore, MD 21224 USA.
[Cheng, M.; Gaiano, N.] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21218 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1091
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502206
ER
PT J
AU Kim, Y
Sharov, A
Mcdole, K
Cheng, M
Hao, H
Fan, CM
Gaiano, N
Ko, M
Zheng, Y
AF Kim, Y.
Sharov, A.
Mcdole, K.
Cheng, M.
Hao, H.
Fan, C-M.
Gaiano, N.
Ko, M.
Zheng, Y.
TI B-type lamins regulates neither their bound genes nor embryonic stem
cells but are essential for organogenesis
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Kim, Y.; Mcdole, K.; Fan, C-M.; Zheng, Y.] Carnegie Inst Sci, Baltimore, MD USA.
[Sharov, A.; Ko, M.] NIA, Dev Genom & Aging Sect, NIH, Baltimore, MD 21224 USA.
[Cheng, M.; Gaiano, N.] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA.
[Hao, H.] JHMI, Microarray Core Facil, Baltimore, MD USA.
RI Ko, Minoru/B-7969-2009
OI Ko, Minoru/0000-0002-3530-3015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 50
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500051
ER
PT J
AU Klebba, JE
Buster, DW
Rusan, NM
Rogers, GC
AF Klebba, J. E.
Buster, D. W.
Rusan, N. M.
Rogers, G. C.
TI Polo-like kinase 4 stability is controlled by autophosphorylation of
multiple residues within its downstream regulatory element.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Klebba, J. E.; Buster, D. W.; Rogers, G. C.] Univ Arizona, Tucson, AZ USA.
[Rusan, N. M.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 892
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502010
ER
PT J
AU Lam, PY
Fischer, RS
Waterman, CM
Huttenlocher, A
AF Lam, P-Y.
Fischer, R. S.
Waterman, C. M.
Huttenlocher, A.
TI F-actin dynamics and actomyosin contraction during neutrophil motility
in live zebrafish
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Lam, P-Y.; Huttenlocher, A.] Univ Wisconsin, Madison, WI USA.
[Fischer, R. S.; Waterman, C. M.] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 338
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500337
ER
PT J
AU Laughlin, RC
Knodler, LA
Payne, HR
Mouneimne, RB
Steele-Mortimer, O
Adams, LG
AF Laughlin, R. C.
Knodler, L. A.
Payne, H. R.
Mouneimne, R. B.
Steele-Mortimer, O.
Adams, L. G.
TI Salmonella enterica Typhimurium associated with enterocyte extrusion in
an in vivo bovine enteric infection model
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Laughlin, R. C.; Payne, H. R.; Mouneimne, R. B.; Adams, L. G.] Texas A&M Univ, College Stn, TX USA.
[Knodler, L. A.; Steele-Mortimer, O.] NIH, Rocky Mt Labs, Hamilton, MT USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1200
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502315
ER
PT J
AU Ma, X
Kovacs, M
Adelstein, RS
AF Ma, X.
Kovacs, M.
Adelstein, R. S.
TI Nonmuscle Myosin II Drives Contractile Ring Constriction by Exerting
Tension on but not Translocating Actin-Filaments
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Ma, X.; Adelstein, R. S.] NHLBI, Mol Cardiol Lab, NIH, Bethesda, MD 20892 USA.
[Kovacs, M.] Eotvos Lorand Univ, ELTE MTA Momentum Motor Enzymol Res Grp, Dept Biochem, H-1364 Budapest, Hungary.
RI Kovacs, Mihaly/A-6841-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 293
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500292
ER
PT J
AU Malicdan, MC
Noguchi, S
Tokutomi, T
Hayashi, YK
Goto, YI
Nishino, I
AF Malicdan, M. C.
Noguchi, S.
Tokutomi, T.
Hayashi, Y. K.
Goto, Y-I.
Nishino, I.
TI Peracetylated N-acetylmannosamine, a synthetic sugar molecule, unravels
important biomarkers in a mouse model of sialic acid deficient myopathy
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Malicdan, M. C.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Malicdan, M. C.; Noguchi, S.] Natl Inst Neurosci, Dept Neuromuscular Res, Kodaira, Tokyo 187, Japan.
[Goto, Y-I.] Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Kodaira, Tokyo 187, Japan.
RI Malicdan, May Christine/F-2806-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 393
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500392
ER
PT J
AU Osborne, LD
Cribb, J
Swaminathan, V
Spero, R
O'Brien, E
Taylor, R
Superfine, R
AF Osborne, L. D.
Cribb, J.
Swaminathan, V.
Spero, R.
O'Brien, E.
Taylor, R.
Superfine, R.
TI High Throughput Passive Rheology Assay for Cancer Cell Mechanics.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Osborne, L. D.; Cribb, J.; Spero, R.; O'Brien, E.; Superfine, R.] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC USA.
[Swaminathan, V.] NHLBI, Lab Cell & Tissue Morphodynam, Bethesda, MD USA.
[Taylor, R.] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 2218
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505504250
ER
PT J
AU Pattabiraman, PP
Lih, FB
Tomer, KB
Rao, V
AF Pattabiraman, P. P.
Lih, F. B.
Tomer, K. B.
Rao, V.
TI The role of Calcium-Independent Phospholipase A2 in homeostasis of
aqueous humor drainage: Ca+2 sensitization of trabecular meshwork
contraction.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Pattabiraman, P. P.; Rao, V.] Duke Univ, Dept Ophthalmol, Durham, NC USA.
[Lih, F. B.; Tomer, K. B.] NIEHS, Mass Spect Grp, Durham, NC USA.
[Rao, V.] Duke Univ, Dept Pharmacol, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 627
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505501180
ER
PT J
AU Plotnikov, SV
Pasapera, A
Sabass, B
Schwarz, U
Waterman, CM
AF Plotnikov, S. V.
Pasapera, A.
Sabass, B.
Schwarz, U.
Waterman, C. M.
TI Oscillatory Coupling between the Extracellular Matrix and the Actin
Cytoskeleton is Essential for Cell Mechanosensing and Durotaxis
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Plotnikov, S. V.; Pasapera, A.; Waterman, C. M.] NHLBI, Bethesda, MD 20892 USA.
[Sabass, B.; Schwarz, U.] Univ Heidelberg, D-6900 Heidelberg, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1531
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503118
ER
PT J
AU Renvoise, B
Stadler, J
Singh, R
Bakowska, J
Blackstone, C
AF Renvoise, B.
Stadler, J.
Singh, R.
Bakowska, J.
Blackstone, C.
TI Spg20-/- mice reveal multimodal functions for Troyer syndrome protein
spartin in lipid droplet maintenance, cytokinesis, and BMP signaling
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Renvoise, B.; Stadler, J.; Singh, R.; Blackstone, C.] NINDS, Cellular Neurol Sect, NIH, Bethesda, MD 20892 USA.
[Bakowska, J.] Loyola Univ Chicago, Dept Pharmacol, Maywood, IL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 118
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500119
ER
PT J
AU Rivera-Dictter, A
Bustamante, H
Munoz, V
Cavieres, V
Mardones, GA
Bonifacino, JS
Burgos, PV
AF Rivera-Dictter, A.
Bustamante, H.
Munoz, V.
Cavieres, V.
Mardones, G. A.
Bonifacino, J. S.
Burgos, P. V.
TI Turnover of amyloid precursor protein carboxy terminal fragment beta
(C99) in lysosomal compartments.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Rivera-Dictter, A.; Bustamante, H.; Munoz, V.; Cavieres, V.; Mardones, G. A.; Burgos, P. V.] Univ Austral Chile, Sch Med, Valdivia, Chile.
[Bonifacino, J. S.] NICHHD, CBMP, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1988
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505504019
ER
PT J
AU Rodgers, L
Anderson, J
Fanning, A
AF Rodgers, L.
Anderson, J.
Fanning, A.
TI Multiple binding domains within the ZO-1 scaffolding protein are
required for proper junction assembly and function
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Rodgers, L.; Fanning, A.] Univ N Carolina, Chapel Hill, NC USA.
[Anderson, J.] NHLBI, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 383
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500382
ER
PT J
AU Ross, BH
Corales, EA
Lin, Y
Hurley, JH
Bonifacino, JS
Burgos, PV
Mardones, GA
AF Ross, B. H.
Corales, E. A.
Lin, Y.
Hurley, J. H.
Bonifacino, J. S.
Burgos, P. V.
Mardones, G. A.
TI Structural and functional characterization of cargo-binding sites of the
mu 4-subunit of adaptor protein complex 4.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Ross, B. H.; Corales, E. A.; Lin, Y.; Burgos, P. V.; Mardones, G. A.] Univ Austral Chile, Sch Med, Valdivia, Chile.
[Hurley, J. H.] NIDDK, LMB, NIH, Bethesda, MD USA.
[Bonifacino, J. S.] NICHHD, CBMP, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1983
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505504014
ER
PT J
AU Subach, O
Patterson, G
Verkhusha, V
AF Subach, O.
Patterson, G.
Verkhusha, V.
TI Photoswitchable orange fluorescent protein forms novel far-red
chromophore after irradiation with visible light
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Subach, O.; Verkhusha, V.] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10467 USA.
[Subach, O.; Verkhusha, V.] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10467 USA.
[Patterson, G.] Natl Inst Biomed Imaging & Bioengn, Biophoton Sect, NIH, Bethesda, MD USA.
RI Subach, Oksana (Gritsenko)/K-7086-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1143
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502258
ER
PT J
AU Swaminathan, V
Mythreye, K
Guilluy, C
O'Brien, E
Blobe, GC
Burridge, K
Superfine, R
AF Swaminathan, V.
Mythreye, K.
Guilluy, C.
O'Brien, E.
Blobe, G. C.
Burridge, K.
Superfine, R.
TI Role of stiffness and force response in integrin mediated signaling and
metastasis.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Swaminathan, V.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Mythreye, K.] Duke Univ, Dept Med, Durham, NC 27706 USA.
[Guilluy, C.; O'Brien, E.; Burridge, K.; Superfine, R.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1874
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503454
ER
PT J
AU Szyk, A
Deaconescu, A
Piszczek, G
Roll-Mecak, A
AF Szyk, A.
Deaconescu, A.
Piszczek, G.
Roll-Mecak, A.
TI The crystal structure of tubulin tyrosine ligase offers insight into
tubulin recognition
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Szyk, A.; Roll-Mecak, A.] NINDS, Cell Biol & Biophys Unit, NIH, Bethesda, MD 20892 USA.
[Piszczek, G.; Roll-Mecak, A.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Deaconescu, A.] Brandeis Univ, Waltham, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 99
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500100
ER
PT J
AU Thievessen, I
Berlemont, S
Plotnikov, S
Zemljic-Harpf, A
Ross, R
Danuser, G
Waterman, C
AF Thievessen, I.
Berlemont, S.
Plotnikov, S.
Zemljic-Harpf, A.
Ross, R.
Danuser, G.
Waterman, C.
TI Differential Requirement for Vinculin in Actin Engagement and Growth of
Focal Adhesions
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Thievessen, I.; Plotnikov, S.; Waterman, C.] NHLBI, Cell Biol & Physiol Ctr, Lab Cell & Tissue Morphodynam, NIH, Bethesda, MD 20892 USA.
[Berlemont, S.; Danuser, G.] Harvard Univ, Sch Med, Dept Cell Biol, Lab Computat Cell Biol, Cambridge, MA 02138 USA.
[Zemljic-Harpf, A.; Ross, R.] Univ Calif San Diego, Sch Med, Dept Med, Div Cardiol, La Jolla, CA 92093 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1577
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503162
ER
PT J
AU Thievessen, I
Fakhri, N
McIsaac, S
Gao, L
Chen, BC
Betzig, E
Oldenbourg, R
Waterman, CM
AF Thievessen, I.
Fakhri, N.
McIsaac, S.
Gao, L.
Chen, B-C.
Betzig, E.
Oldenbourg, R.
Waterman, C. M.
TI Vinculin is required for cell polarization, migration and extracellular
matrix remodeling in three-dimensional collagen matrices
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Thievessen, I.; Waterman, C. M.] NHLBI, Lab Cell & Tissue Morphodynam, NIH, Bethesda, MD 20892 USA.
[Fakhri, N.] Univ Gottingen, Fak Phys, Inst Phys 3, Gottingen, Germany.
[McIsaac, S.] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1525
PG 1
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503112
ER
PT J
AU Weiger, M
Vedhem, V
Stuelten, C
Shou, K
Herrera, M
Losert, W
Parent, C
AF Weiger, M.
Vedhem, V.
Stuelten, C.
Shou, K.
Herrera, M.
Losert, W.
Parent, C.
TI Distinct effects of EGF and LPA on cell migration dynamics during breast
cancer progression.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Weiger, M.; Vedhem, V.; Stuelten, C.; Shou, K.; Parent, C.] NCI, Mol & Cellular Biol Lab, NIH, Bethesda, MD 20892 USA.
[Herrera, M.; Losert, W.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1884
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505503464
ER
PT J
AU Witkin, K
Chong, Y
Shao, S
Webster, M
Lahiri, S
Lee, B
Koh, J
Prinz, W
Andrews, B
Cohen-Fix, O
AF Witkin, K.
Chong, Y.
Shao, S.
Webster, M.
Lahiri, S.
Lee, B.
Koh, J.
Prinz, W.
Andrews, B.
Cohen-Fix, O.
TI The budding yeast nuclear envelope adjacent to the nucleolus serves as a
"membrane sink" during mitotic delay
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Witkin, K.; Shao, S.; Webster, M.; Lahiri, S.; Lee, B.; Prinz, W.; Cohen-Fix, O.] NIDDK, NIH, Bethesda, MD USA.
[Chong, Y.; Koh, J.; Andrews, B.] Univ Toronto, Toronto, ON M5S 1A1, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 145
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500146
ER
PT J
AU Zhang, Y
Conti, M
Malide, D
Dong, F
Wang, A
Shmist, Y
Liu, C
Zerfas, P
Daniels, M
Chan, CC
Kozin, E
Kachar, B
Kelley, M
Kopp, J
Adelstein, RS
AF Zhang, Y.
Conti, M.
Malide, D.
Dong, F.
Wang, A.
Shmist, Y.
Liu, C.
Zerfas, P.
Daniels, M.
Chan, C-C.
Kozin, E.
Kachar, B.
Kelley, M.
Kopp, J.
Adelstein, R. S.
TI Mutations in the Motor and Rod Domains of Murine Nonmuscle Myosin II-A
Cause Similar Defects and Mimic Human MYH9-Related Disease
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Zhang, Y.; Conti, M.; Malide, D.; Wang, A.; Shmist, Y.; Liu, C.; Daniels, M.; Adelstein, R. S.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Dong, F.; Kelley, M.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Daniels, M.] NIH, Off Res Serv, Div Vet Resources, Bethesda, MD 20892 USA.
[Chan, C-C.] NEI, NIH, Bethesda, MD 20892 USA.
[Kozin, E.; Kachar, B.] NIDCD, NIH, Bethesda, MD USA.
[Kelley, M.] Durham Vet Affairs Med Ctr, Med Serv, Durham, NC USA.
[Kopp, J.] NIDDK, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 295
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505500294
ER
PT B
AU Long, LR
Antani, S
Thoma, GR
Deserno, TM
AF Long, L. Rodney
Antani, Sameer
Thoma, George R.
Deserno, Thomas M.
BA Tan, J
BF Tan, J
TI Content-Based Image Retrieval for Advancing Medical Diagnostics,
Treatment and Education
SO NEW TECHNOLOGIES FOR ADVANCING HEALTHCARE AND CLINICAL PRACTICES
LA English
DT Article; Book Chapter
ID INFORMATION-SOCIETY; HEALTH-CARE; SYSTEMS; FUTURE; ANNOTATION
AB Content-Based Image Retrieval (CBIR) technology has been proposed to benefit not only the management of increasingly large medical image collections, but also to aid clinical care, biomedical research, and education. Based on a literature review, we conclude that there is widespread enthusiasm for CBIR in the engineering research community, but the application of this technology to solve practical medical problems is a goal yet to be realized. Furthermore, we highlight "gaps" between desired CBIR system functionality and what has been achieved to date, present a comparative analysis of four state-of-the-art CBIR implementations using the gap approach for illustration, and suggest that high-priority gaps to be overcome lie in CBIR interfaces and functionality that better serve the clinical and biomedical research communities.
C1 [Long, L. Rodney; Antani, Sameer] Natl Lib Med, Commun Engn Branch, Bethesda, MD 20894 USA.
[Deserno, Thomas M.] Rhein Westfal TH Aachen, Sch Med, Div Med Image Proc, Aachen, Germany.
RP Long, LR (reprint author), Natl Lib Med, Commun Engn Branch, Bethesda, MD 20894 USA.
NR 28
TC 2
Z9 2
U1 0
U2 0
PU IGI GLOBAL
PI HERSEY
PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA
BN 978-1-60960-781-4; 978-1-60960-780-7
PY 2011
BP 1
EP 17
DI 10.4018/978-1-60960-780-7.ch001
D2 10.4018/978-1-60960-780-7
PG 17
WC Medical Informatics
SC Medical Informatics
GA BZX78
UT WOS:000303259600002
ER
PT B
AU Muller, H
Kalpathy-Cramer, J
AF Mueller, Henning
Kalpathy-Cramer, Jayashree
BA Tan, J
BF Tan, J
TI Putting the Content Into Context: Features and Gaps in Image Retrieval
SO NEW TECHNOLOGIES FOR ADVANCING HEALTHCARE AND CLINICAL PRACTICES
LA English
DT Article; Book Chapter
ID INFORMATION; SYSTEMS; CAPACITY; STORAGE; FUTURE
AB Digital management of medical images is becoming increasingly important as the number of images being created in medical settings everyday is growing rapidly. Content-based image retrieval or techniques based on the query-by-example paradigm have been studied extensively in computer vision. However, the global, low level visual features automatically extracted by these algorithms do not always correspond to high level concepts that a user has in his mind for searching. The role of image retrieval in diagnostic medicine can be quite complex, making it difficult for the user to express his/her information needs appropriately. Image retrieval in medicine needs to evolve from purely visual retrieval to a more holistic, case-based approach that incorporates various multimedia data sources. These include multiple images, free text, structured data, as well as external knowledge sources and ontologies.
C1 [Mueller, Henning] Univ & Hosp Geneva, Med Informat Serv, MedGIFT Project Med Image Retrieval, Geneva, Switzerland.
[Mueller, Henning] Univ Appl Sci, Zurich, Switzerland.
[Kalpathy-Cramer, Jayashree] Oregon Hlth & Sci Univ, Natl Lib Med, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA.
[Kalpathy-Cramer, Jayashree] Oregon Hlth & Sci Univ, Dept Med Informat, Portland, OR 97201 USA.
RP Muller, H (reprint author), Univ & Hosp Geneva, Med Informat Serv, MedGIFT Project Med Image Retrieval, Geneva, Switzerland.
NR 39
TC 1
Z9 1
U1 0
U2 0
PU IGI GLOBAL
PI HERSEY
PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA
BN 978-1-60960-781-4; 978-1-60960-780-7
PY 2011
BP 105
EP 115
DI 10.4018/978-1-60960-780-7.ch006
D2 10.4018/978-1-60960-780-7
PG 11
WC Medical Informatics
SC Medical Informatics
GA BZX78
UT WOS:000303259600007
ER
PT B
AU Pender, NP
Koroshetz, WJ
AF Pender, Niall P.
Koroshetz, Walter J.
BE Hardiman, O
Doherty, CP
TI Huntington's Disease
SO NEURODEGENERATIVE DISORDERS: A CLINICAL GUIDE
LA English
DT Article; Book Chapter
DE Huntington's disease; Chorea; Huntingtin (protein); GAG repeat;
Neurodegeneration; Neurogenetic (disorder); Presymptomatic genetic
testing; Motor control; Neuropsychiatric; Cognitive disorder; Behavioral
difficulties
ID PHAROS; RISK
AB Huntington's disease (HD) is an autosomal dominant neurodegenerative brain disorder. The mutation was identified in 1993 as an expanded CAG repeat that codes for an abnormally high number of glutamines in the huntingtin protein. At present, there is no known treatment to slow the pace of neurodegeneration, which generally leads to death over a 20-year period after clinical diagnosis. The clinical manifestations of the disease vary widely but they generally include dysfunction in cognition, mood, voluntary motor control, and most patients have the signature finding of chorea.
C1 [Koroshetz, Walter J.] NIH, Neurol Disorders & Stroke Inst, Bethesda, MD 20892 USA.
[Pender, Niall P.] Beaumont Hosp, Dept Psychol, Dublin 9, Ireland.
RP Koroshetz, WJ (reprint author), NIH, Neurol Disorders & Stroke Inst, Bldg 10, Bethesda, MD 20892 USA.
EM koroshetzw@mail.nih.gov
NR 21
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-84996-010-6
PY 2011
BP 167
EP 179
DI 10.1007/978-1-84996-011-3_8
D2 10.1007/978-1-84996-011-3
PG 13
WC Primary Health Care; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA BZW79
UT WOS:000303171300008
ER
PT J
AU Felblinger, DM
AF Felblinger, Dianne M.
BE LanganFox, J
Cooper, CL
TI Incivility and bullying in the nursing workplace
SO HANDBOOK OF STRESS IN THE OCCUPATIONS
SE New Horizons in Management
LA English
DT Article; Book Chapter
ID WORK-ENVIRONMENT; NURSES; SYMPTOMS; VICTIMS; STRESS; STAFF;
PRODUCTIVITY; CONSEQUENCES; OUTCOMES; TRAUMA
C1 Univ Cincinnati, Natl Inst Alcohol Abuse & Alcoholism, Cincinnati, OH 45221 USA.
RP Felblinger, DM (reprint author), Univ Cincinnati, Natl Inst Alcohol Abuse & Alcoholism, Cincinnati, OH 45221 USA.
NR 64
TC 1
Z9 1
U1 1
U2 1
PU EDWARD ELGAR PUBLISHING LTD
PI CHELTENHAM
PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND
BN 978-0-85793-114-6
J9 NEW HORIZ MANAG
PY 2011
BP 5
EP 15
PG 11
WC Psychology, Applied; Management
SC Psychology; Business & Economics
GA BYJ57
UT WOS:000299045400003
ER
PT S
AU Grossman, JH
McNeil, SE
AF Grossman, Jennifer H.
McNeil, Scott E.
BE Alexiou, C
TI Preclinical Efficacy and Toxicity Testing of Engineered Nanomaterials
SO NANOMEDICINE - BASIC AND CLINICAL APPLICATIONS IN DIAGNOSTICS AND
THERAPY
SE Else Kroner-Fresenius Symposia
LA English
DT Proceedings Paper
CT 2nd Else Kroner-Fresenius Symposium
CY SEP 03-05, 2010
CL Erlangen, GERMANY
SP Else Kroner Fresenius Stiftung
ID STERICALLY STABILIZED LIPOSOMES; PHASE-I; NANOPARTICLE INTERACTION;
THERAPEUTIC-EFFICACY; BIODISTRIBUTION; VITRO; VIVO
AB As engineered nanomaterials (ENMs) - man-made products between 1 and approximately 100 nm in size - are increasingly used in consumer, industrial, and medical products, it becomes more important than ever to understand ENM interactions with biology and the environment. Recent results show that seemingly small changes in ENM chemistry can cause dramatic differences in potency and safety, making thorough characterization critical for the manufacture and use of ENMs. Characterization is especially important for ENMs used in medical products. In the pharmaceutical industry, ENMs are being used to reformulate drugs to 'engineer out' disqualifying characteristics such as poor solubility and/or liver and spleen accumulation. In contrast to the development of new molecular entities, using ENMs to reformulate and salvage previously discontinued drugs greatly reduces the time, risk, and investment required for new drug development. Copyright (C) 2011 S. Karger AG, Basel
C1 [McNeil, Scott E.] Natl Canc Inst Frederick Attn, SAIC Frederick Inc, NCI Frederick, Nanotechnol Characterizat Lab, POB B,Bldg 469,1050 Boyles St, Ft Detrick, MD 21702 USA.
RP McNeil, SE (reprint author), Natl Canc Inst Frederick Attn, SAIC Frederick Inc, NCI Frederick, Nanotechnol Characterizat Lab, POB B,Bldg 469,1050 Boyles St, Ft Detrick, MD 21702 USA.
EM ncl@mail.nih.gov
FU National Cancer Institute; National Institutes of Health
[HHSN261200800001E]
FX This project has been funded in whole or in part with federal funds from
the National Cancer Institute, National Institutes of Health, under
contract HHSN261200800001E. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the U.S. Government
NR 23
TC 0
Z9 0
U1 0
U2 1
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 1663-0114
BN 978-3-8055-9818-7
J9 ELSE KRONER FRESEN S
PY 2011
VL 2
BP 71
EP +
PG 2
WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology;
Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Science & Technology - Other
Topics; Research & Experimental Medicine
GA BAG41
UT WOS:000304074300006
ER
PT J
AU Le, SY
Shapiro, BA
AF Le, Shu-Yun
Shapiro, Bruce A.
TI Data mining of functional RNA structures in genomic sequences
SO WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY
LA English
DT Article
ID RIBOSOME ENTRY SITES; SECONDARY STRUCTURE; MESSENGER-RNA; STRUCTURE
PREDICTION; INTERNAL INITIATION; TRANSLATION; MOLECULES; REGIONS;
BINDING; PROTEIN
AB The normal functions of genomes depend on the precise expression of messenger RNAs and noncoding RNAs (ncRNAs) such as transfer RNAs and microRNAs in eukaryotes. These ncRNAs and functional RNA structures (FRSs) act as regulators or response elements for cellular factors and participate in transcription, post-transcriptional processing, and translation. Knowledge discovery of these FRSs in huge DNA/RNA sequence databases is a very important step to reach our goal of going from genomic sequence data to biological knowledge for understanding RNA-based regulation. Analyses of a large number of FRSs have indicated that the FRS can be well characterized by some quantitative measures such as significance and well-ordered scores of the local segment. Various data mining tools have been developed and successfully applied to FRS discovery in genomic sequence databases. Here, we summarize our efforts in the computational discovery of structured features of ncRNAs and FRSs within complex genomes by EDscan and SigED. (C) 2011 John Wiley & Sons, Inc. WIREs DataMining Knowl Discov 2011 1 88-95 DOI: 10.1002/widm.13
C1 [Le, Shu-Yun; Shapiro, Bruce A.] NCI, Ctr Canc Res Nanobiol Program, NCI Ctr Canc Res, Frederick, MD 21701 USA.
RP Le, SY (reprint author), NCI, Ctr Canc Res Nanobiol Program, NCI Ctr Canc Res, Frederick, MD 21701 USA.
EM shuyun@ncifcrf.gov
NR 32
TC 1
Z9 1
U1 0
U2 4
PU WILEY PERIODICALS, INC
PI SAN FRANCISCO
PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA
SN 1942-4787
J9 WIRES DATA MIN KNOWL
JI Wiley Interdiscip. Rev.-Data Mining Knowl. Discov.
PD JAN-FEB
PY 2011
VL 1
IS 1
BP 88
EP 95
DI 10.1002/widm.13
PG 8
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
Methods
SC Computer Science
GA 945FE
UT WOS:000304257400010
ER
PT J
AU Moore, JW
Turner, DC
Corlett, PR
Arana, FS
Morgan, HL
Absalom, AR
Adapa, R
de Wit, S
Everitt, JC
Gardner, JM
Pigott, JS
Haggard, P
Fletcher, PC
AF Moore, James W.
Turner, Danielle C.
Corlett, Philip R.
Arana, Fernando S.
Morgan, Hannah L.
Absalom, Antony R.
Adapa, Ram
de Wit, Sanne
Everitt, Jessica C.
Gardner, Jenny M.
Pigott, Jennifer S.
Haggard, Patrick
Fletcher, Paul C.
TI Ketamine administration in healthy volunteers reproduces aberrant agency
experiences associated with schizophrenia
SO COGNITIVE NEUROPSYCHIATRY
LA English
DT Article
DE Action-outcome binding; Ketamine; Schizophrenia; Sense of agency;
Volition; Voluntary action
ID EMISSION-TOMOGRAPHY PET; CONSCIOUS AWARENESS; PREDICTION-ERROR;
VOLUNTARY ACTION; BODY-OWNERSHIP; PSYCHOSIS; SYMPTOMS; INTENTION;
DELUSIONS; MEMORY
AB Introduction. Aberrant experience of agency is characteristic of schizophrenia. An understanding of the neurobiological basis of such experience is therefore of considerable importance for developing successful models of the disease. We aimed to characterise the effects of ketamine, a drug model for psychosis, on sense of agency (SoA). SoA is associated with a subjective compression of the temporal interval between an action and its effects: This is known as "intentional binding''. This action-effect binding provides an indirect measure of SoA. Previous research has found that the magnitude of binding is exaggerated in patients with schizophrenia. We therefore investigated whether ketamine administration to otherwise healthy adults induced a similar pattern of binding.
Methods. 14 right-handed healthy participants (8 female; mean age 22.4 years) were given low-dose ketamine (100 ng/mL plasma) and completed the binding task. They also underwent structured clinical interviews.
Results. Ketamine mimicked the performance of schizophrenia patients on the intentional binding task, significantly increasing binding relative to placebo. The size of this effect also correlated with aberrant bodily experiences engendered by the drug.
Conclusions. These data suggest that ketamine may be able to mimic certain aberrant agency experiences that characterise schizophrenia. The link to individual changes in bodily experience suggests that the fundamental change produced by the drug has wider consequences in terms of individuals' experiences of their bodies and movements.
C1 [Moore, James W.; Corlett, Philip R.; Arana, Fernando S.; Morgan, Hannah L.; de Wit, Sanne; Everitt, Jessica C.; Fletcher, Paul C.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 3EB, England.
[Turner, Danielle C.] Univ Cambridge, St Johns Coll, Cambridge, England.
[Arana, Fernando S.] NIMH, Clin Brain Disorders Branch, Genes Cognit & Psychosis Program, NIH, Bethesda, MD 20892 USA.
[Absalom, Antony R.] Univ Groningen, Univ Med Ctr Groningen, Dept Anesthesiol, Groningen, Netherlands.
[Absalom, Antony R.; Adapa, Ram] Addenbrookes Hosp, Univ Div Anaesthesia, Cambridge, England.
[de Wit, Sanne] Univ Amsterdam, Amsterdam Ctr Study Adapt Control Brain & Behav A, Dept Psychol, NL-1012 WX Amsterdam, Netherlands.
[Gardner, Jenny M.] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 2QQ, England.
[Pigott, Jennifer S.] UCL, Sch Med, London W1N 8AA, England.
[Haggard, Patrick] UCL, Inst Cognit Neurosci, London, England.
[Corlett, Philip R.] Yale Univ, Sch Med, Dept Psychiat, Connecticut Mental Hlth Ctr,Abraham Ribicoff Res, New Haven, CT USA.
RP Moore, JW (reprint author), Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Downing Site, Cambridge CB2 3EB, England.
EM jm697@cam.ac.uk
RI Adapa, Ram/D-7925-2012;
OI Adapa, Ram/0000-0002-9845-8532; Corlett, Philip/0000-0002-5368-1992;
Absalom, Anthony/0000-0001-7563-9157
FU Wellcome Trust; Bernard Wolfe Health Neuroscience fund; Medical Research
Council
FX This work was supported by the Wellcome Trust and the Bernard Wolfe
Health Neuroscience fund. It was carried out at the Wellcome Trust
Clinical Research Facility (Addenbrooke's Hospital, Cambridge) and
within the Behavioural and Clinical Neurosciences Institute, jointly
supported by the Medical Research Council and the Wellcome Trust. JM and
PCF had full access to all of the data in the study and take
responsibility for the integrity of the data and the accuracy of the
data analysis.
NR 58
TC 13
Z9 14
U1 2
U2 13
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1354-6805
J9 COGN NEUROPSYCHIATRY
JI Cogn. Neuropsychiatry
PY 2011
VL 16
IS 4
BP 364
EP 381
DI 10.1080/13546805.2010.546074
PG 18
WC Psychiatry
SC Psychiatry
GA 945DL
UT WOS:000304252900005
PM 21302161
ER
PT S
AU Orru, CD
Caughey, B
AF Orru, Christina D.
Caughey, Byron
BE Tatzelt, J
TI Prion Seeded Conversion and Amplification Assays
SO PRION PROTEINS
SE Topics in Current Chemistry
LA English
DT Review; Book Chapter
DE Prion composition; PMCA; QuIC; ASA; Transmissible; Spongiform;
Ecephalopathies
ID MISFOLDING CYCLIC AMPLIFICATION; CREUTZFELDT-JAKOB-DISEASE; IN-VITRO
AMPLIFICATION; PROTEASE-RESISTANT FORMS; CHRONIC WASTING DISEASE;
CELL-FREE FORMATION; PRESYMPTOMATIC DETECTION; SENSITIVE DETECTION;
INFECTIOUS PRIONS; MAMMALIAN PRIONS
AB The conversion of the normal prion protein (PrPC) into its misfolded, aggregation-prone and infectious (prion) isoform is central to the progression of transmissible spongiform encephalopathies (TSEs) or prion diseases. Since the initial development of a cell free PrP conversion reaction, striking progress has been made in the development of much more continuous prion-induced conversion and amplification reactions. These studies have provided major insights into the molecular underpinnings of prion propagation and enabled the development of ultra-sensitive tests for prions and prion disease diagnosis. This chapter will provide an overview of such reactions and the practical and fundamental consequences of their development.
C1 [Orru, Christina D.; Caughey, Byron] NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
RP Caughey, B (reprint author), NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
EM bcaughey@nih.gov
NR 63
TC 10
Z9 10
U1 0
U2 10
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0340-1022
BN 978-3-642-24066-9
J9 TOP CURR CHEM
JI Top. Curr. Chem.
PY 2011
VL 305
BP 121
EP 133
DI 10.1007/128_2011_184
D2 10.1007/978-3-642-24067-6
PG 13
WC Chemistry, Multidisciplinary
SC Chemistry
GA BZG42
UT WOS:000301512800006
PM 21678135
ER
PT J
AU Ramus, SJ
Kartsonaki, C
Gayther, SA
Pharoah, PDP
Sinilnikova, OM
Beesley, J
Chen, XQ
McGuffog, L
Healey, S
Couch, FJ
Wang, XS
Fredericksen, Z
Peterlongo, P
Manoukian, S
Peissel, B
Zaffaroni, D
Roversi, G
Barile, M
Viel, A
Allavena, A
Ottini, L
Papi, L
Gismondi, V
Capra, F
Radice, P
Greene, MH
Mai, PL
Andrulis, IL
Glendon, G
Ozcelik, H
Thomassen, M
Gerdes, AM
Kruse, TA
Cruger, D
Jensen, UB
Caligo, MA
Olsson, H
Kristoffersson, U
Lindblom, A
Arver, B
Karlsson, P
Askmalm, MS
Borg, A
Neuhausen, SL
Ding, YC
Nathanson, KL
Domchek, SM
Jakubowska, A
Lubinski, J
Huzarski, T
Byrski, T
Gronwald, J
Gorski, B
Cybulski, C
Debniak, T
Osorio, A
Duran, M
Tejada, MI
Benitez, J
Hamann, U
Rookus, MA
Verhoef, S
Tilanus-Linthorst, MA
Vreeswijk, MP
Bodmer, D
Ausems, MGEM
van Os, TA
Asperen, CJ
Blok, MJ
Meijers-Heijboer, HEJ
Peock, S
Cook, M
Oliver, C
Frost, D
Dunning, AM
Evans, DG
Eeles, R
Pichert, G
Cole, T
Hodgson, S
Brewer, C
Morrison, PJ
Porteous, M
Kennedy, MJ
Rogers, MT
Side, LE
Donaldson, A
Gregory, H
Godwin, A
Stoppa-Lyonnet, D
Moncoutier, V
Castera, L
Mazoyer, S
Barjhoux, L
Bonadona, V
Leroux, D
Faivre, L
Lidereau, R
Nogues, C
Bignon, YJ
Prieur, F
Collonge-Rame, MA
Venat-Bouvet, L
Fert-Ferrer, S
Miron, A
Buys, SS
Hopper, JL
Daly, MB
John, EM
Terry, MB
Goldgar, D
Hansen, TVO
Jonson, L
Ejlertsen, B
Agnarsson, BA
Offit, K
Kirchhoff, T
Vijai, J
Dutra-Clarke, AVC
Przybylo, JA
Montagna, M
Casella, C
Imyanitov, EN
Janavicius, R
Blanco, I
Lazaro, C
Moysich, KB
Karlan, BY
Gross, J
Beattie, MS
Schmutzler, R
Wappenschmidt, B
Meindl, A
Ruehl, I
Fiebig, B
Sutter, C
Arnold, N
Deissler, H
Varon-Mateeva, R
Kast, K
Niederacher, D
Gadzicki, D
Caldes, T
de la Hoya, M
Nevanlinna, H
Aittomaki, K
Simard, J
Soucy, P
Spurdle, AB
Holland, H
Chenevix-Trench, G
Easton, DF
Antoniou, AC
AF Ramus, Susan J.
Kartsonaki, Christiana
Gayther, Simon A.
Pharoah, Paul D. P.
Sinilnikova, Olga M.
Beesley, Jonathan
Chen, Xiaoqing
McGuffog, Lesley
Healey, Sue
Couch, Fergus J.
Wang, Xianshu
Fredericksen, Zachary
Peterlongo, Paolo
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Roversi, Gaia
Barile, Monica
Viel, Alessandra
Allavena, Anna
Ottini, Laura
Papi, Laura
Gismondi, Viviana
Capra, Fabio
Radice, Paolo
Greene, Mark H.
Mai, Phuong L.
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Thomassen, Mads
Gerdes, Anne-Marie
Kruse, Torben A.
Cruger, Dorthe
Jensen, Uffe Birk
Caligo, Maria Adelaide
Olsson, Hakan
Kristoffersson, Ulf
Lindblom, Annika
Arver, Brita
Karlsson, Per
Askmalm, Marie Stenmark
Borg, Ake
Neuhausen, Susan L.
Ding, Yuan Chun
Nathanson, Katherine L.
Domchek, Susan M.
Jakubowska, Anna
Lubinski, Jan
Huzarski, Tomasz
Byrski, Tomasz
Gronwald, Jacek
Gorski, Bohdan
Cybulski, Cezary
Debniak, Tadeusz
Osorio, Ana
Duran, Mercedes
Tejada, Maria-Isabel
Benitez, Javier
Hamann, Ute
Rookus, Matti A.
Verhoef, Senno
Tilanus-Linthorst, Madeleine A.
Vreeswijk, Maaike P.
Bodmer, Danielle
Ausems, Margreet G. E. M.
van Os, Theo A.
Asperen, Christi J.
Blok, Marinus J.
Meijers-Heijboer, Hanne E. J.
Peock, Susan
Cook, Margaret
Oliver, Clare
Frost, Debra
Dunning, Alison M.
Evans, D. Gareth
Eeles, Ros
Pichert, Gabriella
Cole, Trevor
Hodgson, Shirley
Brewer, Carole
Morrison, Patrick J.
Porteous, Mary
Kennedy, M. John
Rogers, Mark T.
Side, Lucy E.
Donaldson, Alan
Gregory, Helen
Godwin, Andrew
Stoppa-Lyonnet, Dominique
Moncoutier, Virginie
Castera, Laurent
Mazoyer, Sylvie
Barjhoux, Laure
Bonadona, Valerie
Leroux, Dominique
Faivre, Laurence
Lidereau, Rosette
Nogues, Catherine
Bignon, Yves-Jean
Prieur, Fabienne
Collonge-Rame, Marie-Agnes
Venat-Bouvet, Laurence
Fert-Ferrer, Sandra
Miron, Alex
Buys, Saundra S.
Hopper, John L.
Daly, Mary B.
John, Esther M.
Terry, Mary Beth
Goldgar, David
Hansen, Thomas V. O.
Jonson, Lars
Ejlertsen, Bent
Agnarsson, Bjarni A.
Offit, Kenneth
Kirchhoff, Tomas
Vijai, Joseph
Dutra-Clarke, Ana V. C.
Przybylo, Jennifer A.
Montagna, Marco
Casella, Cinzia
Imyanitov, Evgeny N.
Janavicius, Ramunas
Blanco, Ignacio
Lazaro, Conxi
Moysich, Kirsten B.
Karlan, Beth Y.
Gross, Jenny
Beattie, Mary S.
Schmutzler, Rita
Wappenschmidt, Barbara
Meindl, Alfons
Ruehl, Ina
Fiebig, Britta
Sutter, Christian
Arnold, Norbert
Deissler, Helmut
Varon-Mateeva, Raymonda
Kast, Karin
Niederacher, Dieter
Gadzicki, Dorothea
Caldes, Trinidad
de la Hoya, Miguel
Nevanlinna, Heli
Aittomaeki, Kristiina
Simard, Jacques
Soucy, Penny
Spurdle, Amanda B.
Holland, Helene
Chenevix-Trench, Georgia
Easton, Douglas F.
Antoniou, Antonis C.
CA OCGN
HEBON
EMBRACE
GEMO Study Collaborators
BCFR
KConFab Investigators
Consortium Investigators Modifiers
TI Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2
Mutation Carriers
SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; BREAST-CANCER; SUSCEPTIBILITY LOCI; GERMLINE
MUTATIONS; ALLELES; IDENTIFICATION; BASONUCLIN-2; POPULATION; PROTEINS;
FAMILIES
AB Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population. We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2.
Methods We genotyped rs3814113 in 10 029 BRCA1 mutation carriers and 5837 BRCA2 mutation carriers. Associations with ovarian and breast cancer were assessed with a retrospective likelihood approach. All statistical tests were two-sided.
Results The minor allele of rs3814113 was associated with a reduced risk of ovarian cancer among BRCA1 mutation carriers (per-allele hazard ratio of ovarian cancer = 0.78, 95% confidence interval = 0.72 to 0.85; P = 4.8 x 10(-9)) and BRCA2 mutation carriers (hazard ratio of ovarian cancer = 0.78, 95% confidence interval = 0.67 to 0.90; P = 5.5 x 10(-4)). This SNP was not associated with breast cancer risk among either BRCA1 or BRCA2 mutation carriers. BRCA1 mutation carriers with the TT genotype at SNP rs3814113 were predicted to have an ovarian cancer risk to age 80 years of 48%, and those with the CC genotype were predicted to have a risk of 33%.
Conclusion Common genetic variation at the 9p22.2 locus was associated with decreased risk of ovarian cancer for carriers of a BRCA1 or BRCA2 mutation.
C1 [Ramus, Susan J.; Gayther, Simon A.] UCL, Dept Gynaecol Oncol, UCL EGA Inst Womens Hlth, London, England.
[Kartsonaki, Christiana; McGuffog, Lesley; Peock, Susan; Cook, Margaret; Oliver, Clare; Frost, Debra; Antoniou, Antonis C.] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.
[Pharoah, Paul D. P.] Univ Cambridge, Strangeways Res Lab, Canc Res United Kingdom Dept Oncol, Cambridge, England.
[Pharoah, Paul D. P.] Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England.
[Sinilnikova, Olga M.] Univ Lyon, Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France.
[Sinilnikova, Olga M.] Univ Lyon, CNRS, Ctr Leon Berard, UMR5201,Equipe Labellisee LIGUE 2008, Lyon, France.
[Beesley, Jonathan; Chen, Xiaoqing; Healey, Sue; Spurdle, Amanda B.; Holland, Helene; Chenevix-Trench, Georgia] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
[Couch, Fergus J.; Wang, Xianshu] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
[Fredericksen, Zachary] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
[Peterlongo, Paolo; Radice, Paolo] Fdn IRCCS Ist Nazl Tumori INT, Dept Expt Oncol & Mol Med, Unit Genet Susceptibil Canc, Milan, Italy.
[Peterlongo, Paolo; Radice, Paolo] Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy.
[Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Roversi, Gaia] Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy.
[Barile, Monica] IEO, Div Canc Prevent & Genet, Milan, Italy.
[Viel, Alessandra] IRCCS, Div Expt Oncol 1, CRO, Aviano, PN, Italy.
[Allavena, Anna] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy.
[Ottini, Laura] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
[Papi, Laura] Univ Florence, Dept Clin Physiopathol, Med Genet Unit, Florence, Italy.
[Gismondi, Viviana] IRCCS Ist Nazl Ric Canc IST, Dept Epidemiol & Prevent, Genoa, Italy.
[Capra, Fabio] Cogentech, Consortium Genom Technol, Milan, Italy.
[Greene, Mark H.; Mai, Phuong L.] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Bethesda, MD 20892 USA.
[Andrulis, Irene L.; Glendon, Gord] Ontario Canc Genet Network, Toronto, ON, Canada.
[Andrulis, Irene L.; Ozcelik, Hilmi] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Thomassen, Mads; Gerdes, Anne-Marie; Kruse, Torben A.] Odense Univ Hosp, DK-5000 Odense, Denmark.
[Gerdes, Anne-Marie] Rigshosp, DK-2100 Copenhagen, Denmark.
[Cruger, Dorthe] Vejle Hosp, Vejle, Denmark.
[Jensen, Uffe Birk] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark.
[Caligo, Maria Adelaide] Univ Hosp Pisa, Dept Oncol, Sect Genet Oncol, Pisa, Italy.
[Ozcelik, Hilmi; Borg, Ake] Lund Univ, Dept Oncol, Lund, Sweden.
[Kristoffersson, Ulf] Lund Univ, Dept Clin Genet, Lund, Sweden.
[Lindblom, Annika] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden.
[Arver, Brita] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
[Karlsson, Per] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
[Askmalm, Marie Stenmark] Linkoping Univ Hosp, Dept Oncol, S-58185 Linkoping, Sweden.
[Neuhausen, Susan L.; Ding, Yuan Chun] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
[Nathanson, Katherine L.; Domchek, Susan M.] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA.
[Nathanson, Katherine L.; Domchek, Susan M.] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
[Jakubowska, Anna; Lubinski, Jan; Huzarski, Tomasz; Byrski, Tomasz; Gronwald, Jacek; Gorski, Bohdan; Cybulski, Cezary; Debniak, Tadeusz] Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain.
[Duran, Mercedes] Univ Valladolid, Inst Biol & Mol Genet IBGM UVA, Valladolid, Spain.
[Tejada, Maria-Isabel] Cruces Hosp Barakaldo, Mol Genet Lab, Dept Biochem, Bizkaia, Spain.
[Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain.
[Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Genotyping Unit, Madrid, Spain.
[Hamann, Ute] Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany.
[Rookus, Matti A.] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands.
[Verhoef, Senno] Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands.
[Tilanus-Linthorst, Madeleine A.] Erasmus MC Daniel den Hoed Canc Ctr, Family Canc Clin, Dept Surg Oncol, Rotterdam, Netherlands.
[Vreeswijk, Maaike P.; Asperen, Christi J.] Leiden Univ, Med Ctr, Ctr Human & Clin Genet, Leiden, Netherlands.
[Bodmer, Danielle] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
[Ausems, Margreet G. E. M.] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.
[van Os, Theo A.] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands.
[Blok, Marinus J.] Univ Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
[Meijers-Heijboer, Hanne E. J.] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands.
[Dunning, Alison M.] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
[Evans, D. Gareth] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
[Pichert, Gabriella] Guys & St Thomas NHS Fdn Trust, London, England.
[Cole, Trevor] Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England.
[Healey, Sue] Univ London, St Georges Hosp, Dept Clin Genet, London, England.
[Brewer, Carole] Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX2 5DW, Devon, England.
[Morrison, Patrick J.] Belfast City Hosp, No Ireland Reg Genet Ctr, Belfast BT9 7AD, Antrim, North Ireland.
[Porteous, Mary] Western Gen Hosp, SE Scotland Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland.
[Kennedy, M. John] Trinity Coll Dublin, Acad Unit Clin & Mol Oncol, Dublin, Eire, Ireland.
[Kennedy, M. John] St James Hosp, Dublin, Eire, Ireland.
[Rogers, Mark T.] Univ Wales Hosp, All Wales Med Genet Serv, Cardiff CF4 4XW, S Glam, Wales.
[Side, Lucy E.] Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England.
[Donaldson, Alan] St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England.
[Gregory, Helen] NHS Grampian, N Scotland Reg Genet Serv, Aberdeen, Scotland.
[Gregory, Helen] Univ Aberdeen, Aberdeen, Scotland.
[Daly, Mary B.] Fox Chase Canc Ctr, Dept Med Oncol, Womens Canc Program, Philadelphia, PA 19111 USA.
[Stoppa-Lyonnet, Dominique; Moncoutier, Virginie; Castera, Laurent] Univ Paris 05, Inst Curie, INSERM, Serv Genet Oncol,U509, Paris, France.
[Manoukian, Siranoush; Barjhoux, Laure] Univ Lyon, Ctr Leon Berard, CNRS, Equipe Labellisee LIGUE 2008,UMR5201, Lyon, France.
[Bonadona, Valerie] Univ Lyon 1, CNRS, UMR5558, Lyon, France.
[Bonadona, Valerie] Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France.
[Leroux, Dominique] Univ Grenoble, Inst Albert Bonniot, Grenoble, France.
[Leroux, Dominique] CHU Grenoble, Dept Genet, F-38043 Grenoble, France.
[Faivre, Laurence] Ctr Hosp Univ Dijon, Ctr Genet, Dijon, France.
[Faivre, Laurence] Ctr Lutte Canc Georges Francois Leclerc, Dijon, France.
[Lidereau, Rosette] INSERM, U735, Ctr Rene Huguenin, St Cloud, France.
[Nogues, Catherine] Ctr Rene Huguenin, Epidemiol Clin, St Cloud, France.
[Bignon, Yves-Jean] Ctr Jean Perrin, Dept Oncogenet, Clermont Ferrand, France.
[Prieur, Fabienne] Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France.
[Collonge-Rame, Marie-Agnes] CHU Besancon, Serv Genet Histol Biol Dev & Reprod, F-25030 Besancon, France.
[Venat-Bouvet, Laurence] Ctr Hosp Univ Dupuytren, Dept Med Oncol, Limoges, France.
[Fert-Ferrer, Sandra] Hotel Dieu Ctr Hosp, Lab Genet Chromosom, Chambery, France.
[Miron, Alex] Dana Farber Canc Inst, Dept Canc Biol, Womens Cancers Program, Boston, MA 02115 USA.
[Buys, Saundra S.] Univ Utah, Hlth Sci Ctr, Huntsman Canc Inst, Salt Lake City, UT USA.
[Hopper, John L.] Univ Melbourne, Melbourne Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
[John, Esther M.] Canc Prevent Inst Calif, Fremont, CA USA.
[John, Esther M.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
[Terry, Mary Beth] Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA.
[Goldgar, David] Univ Utah, Dept Dermatol, Salt Lake City, UT 84112 USA.
[Hansen, Thomas V. O.; Jonson, Lars] Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark.
[Ejlertsen, Bent] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark.
[Agnarsson, Bjarni A.] Univ Hosp, Dept Pathol, Reykjavik, Iceland.
[Agnarsson, Bjarni A.] Univ Iceland, Sch Med, Reykjavik, Iceland.
[Offit, Kenneth; Kirchhoff, Tomas; Vijai, Joseph; Dutra-Clarke, Ana V. C.; Przybylo, Jennifer A.] Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA.
[Montagna, Marco; Casella, Cinzia] Ist Oncol Veneto IRCCS, Immunol & Mol Oncol Unit, Padua, Italy.
[Imyanitov, Evgeny N.] NN Petrov Inst Oncol, St Petersburg, Russia.
[Janavicius, Ramunas] Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.
[Blanco, Ignacio; Lazaro, Conxi] Catalan Inst Oncol, Hereditary Canc Program, Barcelona, Spain.
[Moysich, Kirsten B.] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA.
[Gronwald, Jacek; Karlan, Beth Y.] Cedars Sinai Med Ctr, Womens Canc Res Inst, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA USA.
[Beattie, Mary S.] Univ Calif San Francisco, Canc Risk Program, San Francisco, CA 94143 USA.
[Beattie, Mary S.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
[Beattie, Mary S.] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA.
[Beattie, Mary S.] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA.
[Schmutzler, Rita; Wappenschmidt, Barbara] Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany.
[Schmutzler, Rita; Wappenschmidt, Barbara] Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany.
[Miron, Alex] Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany.
[Ruehl, Ina] Univ Munich, Dept Obstet & Gynaecol, D-80539 Munich, Germany.
[Fiebig, Britta] Univ Regensburg, Inst Human Genet, Regensburg, Germany.
[Sutter, Christian] Univ Heidelberg, Dept Human Genet, Inst Human Genet, Mol Genet Lab, Heidelberg, Germany.
[Arnold, Norbert] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, D-24098 Kiel, Germany.
[Deissler, Helmut] Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany.
[Varon-Mateeva, Raymonda] Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany.
[Kast, Karin] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, Dresden, Germany.
[Niederacher, Dieter] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-4000 Dusseldorf, Germany.
[Gadzicki, Dorothea] Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany.
[Cole, Trevor; de la Hoya, Miguel] Hosp San Carlos, Mol Oncol Lab, Madrid, Spain.
[Nevanlinna, Heli] Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland.
[Aittomaeki, Kristiina] Univ Helsinki, Cent Hosp, Dept Clin Genet, FIN-00290 Helsinki, Finland.
[Simard, Jacques; Soucy, Penny] Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada.
[Simard, Jacques; Soucy, Penny] Univ Laval, Quebec City, PQ, Canada.
[Easton, Douglas F.] Univ Cambridge, Canc Res United Kingdom Genet Epidemiol Unit, Strangeways Res Lab, Cambridge, England.
RP Ramus, SJ (reprint author), Univ So Calif, Dept Prevent Med, Harlyne Norris Res Tower,1450 Biggy St,Rm 2517K, Los Angeles, CA 90033 USA.
EM sramus@usc.edu
RI BYRSKI, Tomasz/I-2844-2014; Jakubowska, Anna/O-8050-2014; GLADIEFF,
Laurence/O-5129-2014; Gardiner, Chris/F-1178-2011; Bodmer,
D./L-4207-2015; Ligtenberg, Marjolijn/N-9666-2013; Gronwald,
Jacek/A-4576-2017; manoukian, siranoush/E-7132-2017; Peissel,
Bernard/E-8187-2017; Blanco, Ignacio/D-2565-2013; Oosterwijk, Jan
C./G-5770-2011; Leroux, Dominique/G-7309-2014; Osorio, Ana/I-4324-2014;
Arnold, Norbert/E-3012-2010; montagna, marco/E-2225-2012; Hereditario,
Cancer/E-3311-2012; M Isabel, Tejada/E-2394-2012; Lester,
Jenny/B-5933-2012; Andrulis, Irene/E-7267-2013; Joseph,
Vijai/J-9158-2013; Hoogerbrugge, Nicoline/O-1016-2013; Radice,
Paolo/O-3119-2013; Spurdle, Amanda/A-4978-2011;
OI Kirchhoff, Tomas/0000-0002-9055-2364; Dunning, Alison
Margaret/0000-0001-6651-7166; VENAT-BOUVET,
Laurence/0000-0002-0716-2550; Evans, Gareth/0000-0002-8482-5784;
GLADIEFF, Laurence/0000-0002-6980-9719; Gardiner,
Chris/0000-0002-2318-0062; Ligtenberg, Marjolijn/0000-0003-1290-1474;
Gronwald, Jacek/0000-0002-3643-2871; manoukian,
siranoush/0000-0002-6034-7562; Peissel, Bernard/0000-0001-9233-3571;
Janavicius, Ramunas/0000-0002-3773-8485; Nathanson,
Katherine/0000-0002-6740-0901; Blanco, Ignacio/0000-0002-7414-7481;
Osorio, Ana/0000-0001-8124-3984; Arnold, Norbert/0000-0003-4523-8808;
montagna, marco/0000-0002-4929-2150; Joseph, Vijai/0000-0002-7933-151X;
TEJADA, Maria-Isabel/0000-0002-7334-1864; Eeles,
Rosalind/0000-0002-3698-6241; Ramus, Susan/0000-0003-0005-7798; Spurdle,
Amanda/0000-0003-1337-7897; Papi, Laura/0000-0003-4552-9517; Nevanlinna,
Heli/0000-0002-0916-2976
FU National Cancer Institute (NCI); National Institutes of Health
[RFA-CA-06-503, P50 CA83638, U01 CA69631, 5U01 CA113916, R01 CA128978,
P50 CA116201, R01 CA74415, RTICC 06/0020/0021, FIS 070359, FIS 090085];
Cancer Care Ontario [U01 CA69467]; Columbia University [U01 CA69398];
Fox Chase Cancer Center [U01 CA69631]; Huntsman Cancer Institute [U01
CA69446]; Northern California Cancer Center [U01 CA69417]; University of
Melbourne [U01 CA69638]; Research Triangle Institute Informatics Support
Center (RFP) [N02PC45022-46]; Neye Foundation; Fundacion Mutua
Madrilena; Asociacion Espanola Contra el Cancer; Spanish Ministry of
Science and Innovation [FIS PI08 1120]; Basque Foundation for Health
Innovation and Research (BIOEF) [BIO07/CA/006]; Associazione Italiana
per la Ricerca sul Cancro [4017, 8713]; Ministero della Salute [1 RC
D/08/02B, RFPS-2006-3-340203]; Fondazione Italiana per la Ricerca sul
Cancro; Ministero dell'Universita' e Ricerca [RBLAO3-BETH]; DKFZ;
National Institute of Health Research; Royal Marsden NHS Foundation
Trust; Cancer Research UK [C5047/A8385, C1287/A10118, C1287/A8874,
C8197/A10123, C8197/A10865]; Eileen Stein Jacoby Fund; Ligue National
Contre le Cancer; Association for International Cancer Research
[AICR-07-0454]; Association "Le cancer du sein, parlons-en!"; Hereditary
Breast and Ovarian Cancer Research Group Netherlands (HEBION); Dutch
Cancer Society [NKI 1998-1854, NKI 2004-3088, NKI 2007-3756]; Helsinki
University Central Hospital; Academy of Finland [132473]; Finnish Cancer
Society; Sigrid Juselius Foundation; State Committee for Scientific
Research [PBZ_KBN_122/P05/2004]; Canadian Institutes of Health Research
[CRN_87521]; Canadian Breast Cancer Research Alliance [019511]; Istituto
Oncologico Veneto-Hereditary Breast Ovarian Cancer Study: "Ministero
della Salute" [RFPS 2006-5-341353, ACC2/R6.9]; National Breast Cancer
Foundation; National Health and Medical Research Council (NHMRC);
Queensland Cancer Fund; Cancer Council of New South Wales; Cancer
Council of Victoria; Cancer Council of Tasmania; Cancer Council of South
Australia; Cancer Foundation of Western Australia; Komen race for the
cure [KG081527]; Breast Cancer Research Foundation; Lomangino Family
Research Fund; US NCI at the National Institutes of Health
[NO2-CP-11019-50, N02-CP-65504]; Westat, Inc, Rockville, MD; Russian
Foundation for Basic Research [08-04-00369-a, 10-04-92110,
10-04-92110-a]; Federal Agency for Science and Innovations
[02.740.11.0780]; Commission of the European Communities
[PITN-GA-2009-238132]; Royal Society [JP090615]; Cancer Care Ontario,
Canada; NCI, National Institutes of Health [RFA-CA-06-503]; Istituto
Toscano Tumori; Swedish Cancer Society; CRUK; Department of Health's
NIHR Biomedical Research Centre; Cancer Genetics Network
[HHSN21620074400C]; American Cancer Society; L & S Milken Family
Foundation; Entertainment Industry Foundation
FX The CIMBA data management and data analysis was supported by Cancer
Research UK grants (to D. F. E. and A. C. A.). G.C.-T. founded CIMBA to
provide the infrastructure to study genetic modifiers of cancer risk for
BRCA1 and BRCA2 mutation carriers.; Breast Cancer Family Registry
(BCFR): Supported by the National Cancer Institute (NCI), National
Institutes of Health under RFA-CA-06-503 and through cooperative
agreements with members of the BCFR and Principal Investigators (PIs),
including Cancer Care Ontario (U01 CA69467), Columbia University (U01
CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer
Institute (U01 CA69446), Northern California Cancer Center (U01
CA69417), University of Melbourne (U01 CA69638), and Research Triangle
Institute Informatics Support Center (RFP No. N02PC45022-46). The
content of this article does not necessarily reflect the views or
policies of the NCI or any of the collaborating centers in the BCFR nor
does mention of trade names, commercial products, or organizations imply
endorsement by the US Government or the BCFR.; Copenhagen Breast Cancer
Study (CBCS): Supported by the Neye Foundation.; Spanish National Cancer
Center (CNIO) and the Spanish Consortium: Partially supported by
Fundacion Mutua Madrilena, Asociacion Espanola Contra el Cancer, and the
Spanish Ministry of Science and Innovation (FIS PI08 1120).; Funded in
part by the Basque Foundation for Health Innovation and Research (BIOEF)
(BIO07/CA/006).; CONsorzio Studi Italiani Tumori Ereditari Alla Mammella
(CONSIT TEAM): Supported by grants from Associazione Italiana per la
Ricerca sul Cancro (4017) and by funds from Italian citizens who
allocated the 5x1000 share of their tax payment in support of the
Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws
(INT-Institutional strategic projects "5x1000") to P. P. Supported by
grants from Ministero della Salute ("Progetto Tevere"-Linea 1 RC
D/08/02B-"Progetto Tumori Femminili"-F/08/0PZ-Lineal RC CORR/08) to S.
M. Supported by grants from Associazione Italiana per la Ricerca sul
Cancro (8713) to L.O. Supported by grants from Ministero della Salute
(Extraordinary National Cancer Program 2006, "Alleanza contro il Cancro"
and Integrated Program N.5) to V. G. Supported by grants from Fondazione
Italiana per la Ricerca sul Cancro (Special Project "Hereditary
tumors"), Ministero della Salute (RFPS-2006-3-340203, Extraordinary
National Cancer Program 2006 "Alleanza contro il Cancro," and "Progetto
Tumori Femminili") and Ministero dell'Universita' e Ricerca
(RBLAO3-BETH) to P.R.; Deutsches Krebsforschungszentrum (DKFZ) study:
Supported by the DKFZ.; Epidemiological study of BRCA1 and BRCA2
mutation carriers (EMBRACE): Cancer Research UK grants (C1287/A10118 and
C1287/A8874 to D. F. E., S. P., M. C., D. F., and C.O., and C8197/A10123
and C8197/A10865 to A. M. D.). National Institute for Health Research
grant to the Biomedical Research Centre, Manchester (D. G. E.). The
Investigators at the Institute of Cancer Research and the Royal Marsden
NHS Foundation Trust are supported by a National Institute of Health
Research grant to the Biomedical Research Centre at the Institute of
Cancer Research and the Royal Marsden NHS Foundation Trust. Cancer
Research UK grant (C5047/A8385 to R. E., E. B., and L. D'M.).; Fox Chase
Cancer Center (FCCC): National Institutes of Health (P50 CA83638, U01
CA69631, and 5U01 CA113916 to A. K. G.); Eileen Stein Jacoby Fund.; The
German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC):
German Cancer Aid (107054).; Genetic Modifiers of cancer risk in BRCA1/2
mutation carriers (GEMO): Cancer Genetics Network "Groupe Genetique et
Cancer," Federation Nationale des Centres de Lutte Contre le Cancer,
France, is supported by the Ligue National Contre le Cancer; Association
for International Cancer Research grant (AICR-07-0454); Association "Le
cancer du sein, parlons-en!" Award.; The Hereditary Breast and Ovarian
Cancer Research Group Netherlands (HEBON): Dutch Cancer Society (NKI
1998-1854, NKI 2004-3088 and NKI 2007-3756).; Hospital Clinico San
Carlos: National Institute of Health Carlos III (RTICC 06/0020/0021, FIS
070359, and FIS 0900850).; Helsinki Breast Cancer Study (HEBCS):
Helsinki University Central Hospital Research Fund, Academy of Finland
(132473), the Finnish Cancer Society, and the Sigrid Juselius
Foundation.; International Hereditary Cancer Center: State Committee for
Scientific Research (PBZ_KBN_122/P05/2004).; Interdisciplinary Health
Research International Team Breast Cancer Susceptibility (INHERIT
BRCAs): Canadian Institutes of Health Research for the "CIHR Team in
Familial Risks of Breast Cancer" program (CRN_87521); Canadian Breast
Cancer Research Alliance (019511).; Istituto Oncologico
Veneto-Hereditary Breast Ovarian Cancer Study: "Ministero della Salute"
(RFPS 2006-5-341353, ACC2/R6.9).; KCONFAB: National Breast Cancer
Foundation, the National Health and Medical Research Council (NHMRC),
and the Queensland Cancer Fund, the Cancer Councils of New South Wales,
Victoria, Tasmania and South Australia, and the Cancer Foundation of
Western Australia. A. B. S. and G.C.-T. are Senior and Senior Principal
Research Fellows of the NHMRC, respectively.; Mayo Clinic Study:
National Institutes of Health (R01 CA128978 and P50 CA116201); Komen
race for the cure (KG081527); Breast Cancer Research Foundation.;
Memorial Sloane Kettering Cancer Center: Breast Cancer Research
Foundation and the Lomangino Family Research Fund.; NCI: Intramural
Research Program of the US NCI at the National Institutes of Health;
support services contracts (NO2-CP-11019-50 and N02-CP-65504 to P. L. M.
and M. H. G.) with Westat, Inc, Rockville, MD.; N.N. Petrov Institute of
Oncology: Russian Foundation for Basic Research (08-04-00369-a,
10-04-92110 and 10-04-92110-a); Federal Agency for Science and
Innovations (contract 02.740.11.0780); Commission of the European
Communities (PITN-GA-2009-238132); Royal Society International Joint
(JP090615).; Ontario Cancer Genetics Network (OCGN): Supported by Cancer
Care Ontario, Canada (I. L. A.); and the NCI, National Institutes of
Health under RFA-CA-06-503 and through cooperative agreements with
members of the BCFR and PIs. The content of this article does not
necessarily reflect the views or policies of the NCI or any of the
collaborating centers in the Cancer Family Registry (CFR) nor does
mention of trade names, commercial products, or organizations imply
endorsement by the US Government or the CFR.; Pisa Breast Cancer Study:
Fondazione Cassa di Risparmio di Pisa (122/07) and grant 2010 from
Istituto Toscano Tumori.; Swedish Breast Cancer Study (SWE-BRCA):
Supported by the Swedish Cancer Society.; University of California
Irvine: National Institutes of Health (R01 CA74415 to SLN and Y.C.D.).;
University of California San Francisco (UCSF): Clinical and
Translational Science Institute at the University of California, San
Francisco (to M. S. B.).; UK and Gilda Radner Familial Ovarian Cancer
Registries (UKGRFOCR): UKFOCR was supported by a project grant from CRUK
to P. P. Some of this work was undertaken at UCLH/UCL who received a
proportion of funding from the Department of Health's NIHR Biomedical
Research Centre funding scheme.; University of Pennsylvania: Breast
Cancer Research Foundation (K.L.N.); Cancer Genetics Network
(HHSN21620074400C to S. M. D.).; Women's Cancer Research Institute:
Supported in part by the American Cancer Society Early Detection
Professorship, L & S Milken Family Foundation, and Entertainment
Industry Foundation.
NR 43
TC 22
Z9 22
U1 1
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
EI 1460-2105
J9 JNCI-J NATL CANCER I
JI JNCI-J. Natl. Cancer Inst.
PD JAN
PY 2011
VL 103
IS 2
DI 10.1093/jnci/djq494
PG 12
WC Oncology
SC Oncology
GA 709WT
UT WOS:000286472800008
PM 21169536
ER
PT S
AU Sa, JM
Chong, JL
Wellems, TE
AF Sa, Juliana M.
Chong, Jason L.
Wellems, Thomas E.
BE Docampo, R
TI Malaria drug resistance: new observations and developments
SO ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY
SE Essays in Biochemistry
LA English
DT Review; Book Chapter
ID PLASMODIUM-FALCIPARUM MALARIA; SINGLE-NUCLEOTIDE POLYMORPHISMS;
TRANSMEMBRANE PROTEIN PFCRT; PAPUA-NEW-GUINEA; CHLOROQUINE-RESISTANCE;
ARTEMISININ RESISTANCE; QUININE RESISTANCE; IN-VITRO; PVCRT-O;
SULFADOXINE-PYRIMETHAMINE
AB Drug-resistant micro-organisms became widespread in the 20th Century, often with devastating consequences, in response to widespread use of natural and synthetic drugs against infectious diseases. Antimalarial resistance provides one of the earliest examples, following the introduction of new medicines that filled important needs for prophylaxis and treatment around the globe. In the present chapter, we offer a brief synopsis of major antimalarial developments from two natural remedies, the qinghaosu and cinchona bark infusions, and of synthetic drugs inspired by the active components of these remedies. We review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine. Finally, we discuss some new observations on the molecular genetics of drug resistance, including delayed parasite clearances that have been increasingly observed in response to artemisinin derivatives in regions of South-East Asia.
C1 [Sa, Juliana M.; Chong, Jason L.; Wellems, Thomas E.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
RP Wellems, TE (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
EM twellems@niaid.nih.gov
FU Intramural NIH HHS [Z99 AI999999]
NR 121
TC 23
Z9 23
U1 0
U2 20
PU PORTLAND PRESS LTD
PI LONDON
PA 59 PORTLAND PL, LONDON W1N 3AJ, ENGLAND
SN 0071-1365
BN 978-1-85578-184-9
J9 ESSAYS BIOCHEM
JI Essays Biochem.
PY 2011
VL 51
BP 137
EP 160
DI 10.1042/BSE0510137
PG 24
WC Biochemistry & Molecular Biology; Parasitology
SC Biochemistry & Molecular Biology; Parasitology
GA BZX40
UT WOS:000303215500010
PM 22023447
ER
PT S
AU Seol, Y
Neuman, KC
AF Seol, Yeonee
Neuman, Keir C.
BE Peterman, EJG
Wuite, GJL
TI Magnetic Tweezers for Single-Molecule Manipulation
SO SINGLE MOLECULE ANALYSIS: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Magnetic tweezers; Image tracking; DNA; Topology; Single molecule
ID OPTICAL MICROSCOPE; DNA; MICROMANIPULATION; MOTION; LEVEL; TRAP
AB Magnetic tweezers provide a versatile tool enabling the application of force and torque on individual biomolecules. Magnetic tweezers are uniquely suited to the study of DNA topology and protein DNA interactions that modify DNA topology. Perhaps due to its presumed simplicity, magnetic tweezers instrumentation has been described in less detail than comparable techniques. Here, we provide a comprehensive description and guide for the design and implementation of a magnetic tweezers instrument for single-molecule measurements of DNA topology and mechanics. We elucidate magnetic trap design, as well as microscope and illumination setup, and provide a simple LabVIEW-based real-time position tracking algorithm. In addition, we provide procedures for production of supercoilable DNA tethers, flow-cell design, and construction tips.
C1 [Seol, Yeonee; Neuman, Keir C.] NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA.
RP Seol, Y (reprint author), NHLBI, Lab Mol Biophys, NIH, Bldg 10, Bethesda, MD 20892 USA.
RI Neuman, Keir/F-7400-2011
OI Neuman, Keir/0000-0002-0863-5671
FU Intramural NIH HHS
NR 21
TC 13
Z9 13
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-281-6
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 783
BP 265
EP 293
DI 10.1007/978-1-61779-282-3_15
D2 10.1007/978-1-61779-282-3
PG 29
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Physics,
Applied
SC Biochemistry & Molecular Biology; Physics
GA BYV34
UT WOS:000300583200015
PM 21909894
ER
PT S
AU Nordstrom, RJ
AF Nordstrom, Robert J.
BE Nordstrom, RJ
Cote, GL
TI Phantoms as Standards in Optical Measurements
SO OPTICAL DIAGNOSTICS AND SENSING XI: TOWARD POINT-OF-CARE DIAGNOSTICS AND
DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH
OPTICAL MEASUREMENT OF TISSUE III
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Optical Diagnostics and Sensing XI - Toward Point-of-Care
Diagnostics and Design and Performance Validation of Phantoms Used in
Conjunction with Optical Measurement of Tissue III
CY JAN 22-26, 2011
CL San Francisco, CA
SP SPIE
DE Phantoms; translational research; standardization
ID TUMOR CHANGE MEASUREMENT; TRUTH DATA; ERROR SOURCES; THERAPY
AB As optical technology progresses through the translational research pipeline, phantoms are becoming more important as verification tools to demonstrate proper performance of the devices before clinical studies. Because of the wide range of optical methodologies, there can be no single phantom that is useful for all modes of imaging, but protocols for phantom use should be organized to stand as standards. This paper discusses the features that phantoms must have to be considered as standards for optical measurements.
C1 NCI, NIH, Bethesda, MD 20892 USA.
RP Nordstrom, RJ (reprint author), NCI, NIH, 6130 Execut Blvd, Bethesda, MD 20892 USA.
NR 7
TC 7
Z9 7
U1 1
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8443-7
J9 PROC SPIE
PY 2011
VL 7906
AR 79060H
DI 10.1117/12.876374
PG 5
WC Optics; Radiology, Nuclear Medicine & Medical Imaging
SC Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BZS23
UT WOS:000302694400013
ER
PT J
AU Gilfillan, AM
Beaven, MA
AF Gilfillan, Alasdair M.
Beaven, Michael A.
TI Regulation of Mast Cell Responses in Health and Disease
SO CRITICAL REVIEWS IN IMMUNOLOGY
LA English
DT Article
DE mast cells; Fc epsilon RI; KIT; GPCRs; TLR/ST2/NOD-like receptors;
signaling; immunity; allergies; autoimmune diseases
ID FC-EPSILON-RI; PROTEIN-KINASE-C; THYMIC STROMAL LYMPHOPOIETIN; AFFINITY
IGE RECEPTOR; A(3) ADENOSINE RECEPTOR; TOLL-LIKE RECEPTOR-2;
SMOOTH-MUSCLE-CELLS; CATHELICIDIN ANTIMICROBIAL PEPTIDE; RAT
GASTROINTESTINAL MUCOSA; RENIN-ANGIOTENSIN SYSTEM
AB Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection. They are also thought to play a role in angiogenesis, tissue remodeling, wound healing, and tumor repression or growth. The broad scope of these physiologic and pathologic roles illustrates the flexible nature of mast cells, which is enabled in part by their phenotypic adaptability to different tissue microenvironments and their ability to generate and release a diverse array of bioactive mediators in response to multiple types of cell-surface and cytosolic receptors. There is increasing evidence from studies in cell cultures that release of these mediators can be selectively modulated depending on the types or groups of receptors activated. The intent of this review is to foster interest in the interplay among mast cell receptors to help understand the underlying mechanisms for each of the immunological and non-immunological functions attributed to mast cells. The second intent of this review is to assess the pathophysiologic roles of mast cells and their products in health and disease. Although mast cells have a sufficient repertoire of bioactive mediators to mount effective innate and adaptive defense mechanisms against invading microorganisms, these same mediators can adversely affect surrounding tissues in the host, resulting in autoimmune disease as well as allergic disorders.
C1 [Gilfillan, Alasdair M.] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA.
[Beaven, Michael A.] NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA.
RP Gilfillan, AM (reprint author), NIAID, Lab Allerg Dis, NIH, 10 Ctr Dr,MSC 1881, Bethesda, MD 20892 USA.
EM agilfillan@niaid.nih.gov
FU National Institute of Allergy and Infectious Disease; National Heart,
Lung, and Blood Institute, National Institutes of Health
FX Work in the authors' laboratories has been supported by funding from the
Intramural Research Program of the National Institute of Allergy and
Infectious Disease and National Heart, Lung, and Blood Institute,
National Institutes of Health. Due to space limitations, we do not cite
all pertinent literature when adequately covered by most recent reviews.
This does not imply that studies not quoted are of lesser merit.
NR 454
TC 80
Z9 87
U1 3
U2 16
PU BEGELL HOUSE INC
PI REDDING
PA 50 CROSS HIGHWAY, REDDING, CT 06896 USA
SN 1040-8401
J9 CRIT REV IMMUNOL
JI Crit. Rev. Immunol.
PY 2011
VL 31
IS 6
BP 475
EP 529
PG 55
WC Immunology
SC Immunology
GA 926IU
UT WOS:000302825300003
PM 22321108
ER
PT S
AU Chadwick, RS
Grosh, K
AF Chadwick, Richard S.
Grosh, Karl
BE Shera, CA
Olson, ES
TI Wave Propagation and Amplification in the Cochlea-A Moderated Discussion
SO WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS:
PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 11th International Workshop on the Mechanics of Hearing
CY JUL 16-22, 2011
CL Williams Coll, Williamstown, MA
HO Williams Coll
DE cochlear mechanics; traveling waves; DPOAEs; cochlear amplifier
AB A discussion moderated by the authors on the topics "Wave Propagation in the Cochlea" and "The Cochlear Amplifier" was held on 21 July 2011 at the 11th International Mechanics of Hearing Workshop in Williamstown, Massachusetts. The paper provides an edited transcript of the session.
C1 [Chadwick, Richard S.] NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA.
[Grosh, Karl] Univ Michigan, Dept Mech Engn, Ann Arbor, MI USA.
RP Chadwick, RS (reprint author), NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA.
FU NIH [R13 DC010930]; AFOSR [FA9550-11-1-0102]
FX Originally transcribed by Virginia Dodge from audio recordings, the
discussion presented here was edited by R.S. Chadwick, K. Grosh, E.S.
Olson, and C.A. Shera. Discussions at the Mechanics of HearingWorkshop
were supported by grants from the NIH (R13 DC010930) and the AFOSR
(FA9550-11-1-0102).
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0975-0
J9 AIP CONF PROC
PY 2011
VL 1403
DI 10.1063/1.3658173
PG 3
WC Audiology & Speech-Language Pathology; Physics, Applied
SC Audiology & Speech-Language Pathology; Physics
GA BZL60
UT WOS:000301945200122
ER
PT S
AU Lamb, JS
Chadwick, RS
AF Lamb, Jessica S.
Chadwick, Richard S.
BE Shera, CA
Olson, ES
TI Unraveling Traveling Waves Using WKB Modeling
SO WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS:
PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 11th International Workshop on the Mechanics of Hearing
CY JUL 16-22, 2011
CL Williams Coll, Williamstown, MA
HO Williams Coll
DE cochlear mechanics; WKB; tectorial membrane; wave propagation; mode
conversion
ID TECTORIAL MEMBRANE; COCHLEAR MECHANICS; MOTION; CORTI; ORGAN; 2ND
AB We calculate traveling waves in the cochlear partition using a WKB-based mechanical model in which motions of the fluid-interacting tectorial membrane (TM) and basilar membrane (BM) are degrees of freedom. We find that the two modes of motion that result manifest themselves as two traveling waves, each carried on both the BM and on the TM. The waves produce distinct tuning curves for the TM and the BM. We discuss the influence of the TM and coupling stiffnesses on the waves and tuning curves. We speculate how the two modes of motion we calculate and the differential motions they cause could influence the cochlear amplifier. We also discuss the possibility that mode conversion could occur in the cochlea.
C1 [Lamb, Jessica S.; Chadwick, Richard S.] NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA.
RP Lamb, JS (reprint author), NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0975-0
J9 AIP CONF PROC
PY 2011
VL 1403
DI 10.1063/1.3658067
PG 7
WC Audiology & Speech-Language Pathology; Physics, Applied
SC Audiology & Speech-Language Pathology; Physics
GA BZL60
UT WOS:000301945200016
ER
PT S
AU Schones, DE
Cui, KR
Cuddapah, S
AF Schones, Dustin E.
Cui, Kairong
Cuddapah, Suresh
BE Castrillo, JI
Oliver, SG
TI Genome-Wide Approaches to Studying Yeast Chromatin Modifications
SO YEAST SYSTEMS BIOLOGY: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Chromatin; histone modifications; ChIP-Seq; nucleosomes; genomics;
epigenomics
AB The genomes of eukaryotic organisms are packaged into nuclei by wrapping DNA around proteins in a structure known as chromatin. The most basic unit of chromatin, the nucleosome, consists of approximately 146 bp of DNA wrapped around an octamer of histone proteins. The placement of nucleosomes relative to a gene can influence the regulation of the transcription of this gene. Furthermore, the N-terminal tails of histone proteins are subjected to numerous post-translational modifications that are also known to influence gene regulation. In recent years, a number of genome-scale approaches to identify modifications to chromatin have been developed. Techniques combining chromatin immunoprecipitation (ChIP) with microarrays (ChIP-chip) and second-generation sequencing (ChIP-Seq) have led to great advances in our understanding of how chromatin modifications contribute to gene regulation. Many excellent protocols related to ChIP-chip have been published recently (Lieb, J. D. (2003) Genome-wide mapping of protein-DNA interactions by chromatin immunoprecipitation and DNA microarray hybridization. Methods Mol. Biol. 224,99-109.). For this reason, we will focus our attention here on the application of second-generation sequencing platforms to the study of chromatin modifications in yeast. As these genome-scale experiments require both wet-lab and bioinformatic components to reach their full potential, we will detail both the wet-lab protocols and bioinformatic steps necessary to frilly conduct genome-scale studies of chromatin modifications.
C1 [Schones, Dustin E.] City Hope Natl Med Ctr, Duarte, CA 91010 USA.
[Cuddapah, Suresh] NYU, Dept Environm Med, Tuxedo Pk, NY USA.
[Cui, Kairong] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
RP Schones, DE (reprint author), City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA.
FU Intramural NIH HHS
NR 9
TC 1
Z9 1
U1 1
U2 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-172-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 759
BP 61
EP 71
DI 10.1007/978-1-61779-173-4_4
D2 10.1007/978-1-61779-173-4
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BYV48
UT WOS:000300590000005
PM 21863481
ER
PT J
AU Sclafani, V
Paukner, A
Suomi, SJ
Ferrari, PF
AF Sclafani, V.
Paukner, A.
Suomi, S. J.
Ferrari, P. F.
TI Imitation Promotes Affiliation in Infant Macaques (Macaca mulatta)
SO FOLIA PRIMATOLOGICA
LA English
DT Meeting Abstract
DE Imitation recognition; Affiliation; Empathy; Infant Development; Rhesus
macaques
C1 [Sclafani, V.; Ferrari, P. F.] Univ Parma, Dipartimento Biol Evolut & Funz, I-43100 Parma, Italy.
[Paukner, A.; Suomi, S. J.] NICHHD, Comparat Ethol Lab, Poolesville, MD USA.
EM valentinasclafani@libero.it
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0015-5713
J9 FOLIA PRIMATOL
JI Folia Primatol.
PY 2011
VL 82
IS 4-5
BP 266
EP 266
PG 1
WC Zoology
SC Zoology
GA 917UE
UT WOS:000302203300036
ER
PT S
AU Kuo, JC
Han, XM
Yates, JR
Waterman, CM
AF Kuo, Jean-Cheng
Han, Xuemei
Yates, John R., III
Waterman, Clare M.
BE Shimaoka, M
TI Isolation of Focal Adhesion Proteins for Biochemical and Proteomic
Analysis
SO INTEGRIN AND CELL ADHESION MOLECULES: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Focal adhesion; Immunofluorescence; Western blotting; Mass spectrometry;
Integrin
ID SHOTGUN PROTEOMICS; MASS-SPECTROMETRY; YEAST PROTEOME; ABUNDANCE;
MATRIX; MS/MS
AB Focal adhesions (FAs) are discrete plasma membrane-associated adhesive organelles that play dual roles in cell force transduction and signaling. FAs consist of clustered transmembrane heterodimeric integrin extracellular matrix (ECM) receptors and a large number of cytoplasmic proteins that collectively form thin plaques linking the ECM to actin filament bundles of the cytoskeleton. FAs are complex organelles that can change their composition in response to biochemical or mechanical cues. These compositional differences may underlie the ability of FAs to mediate an array of important cell functions including adhesion, signaling, force transduction, and regulation of the cytoskeleton. These functions contribute to the physiological processes of the immune response, development, and differentiation. However, linking FA composition to FA function has been difficult since there has been no method to isolate intact FAs reproducibly and determine their composition. We report here a new method for isolating FA structures in cultured cells distinct from cytoplasmic, nuclear, and internal membranous organellar components of the cell. We provide protocols for validation of the fractionation by immunofluorescence and immuno-blotting, procedures for preparing the isolated FAs for mass spectrometric proteomic analysis, tips on data interpretation and analysis, and an approach for comparing FA composition in cells in which small GTPase signaling is perturbed.
C1 [Kuo, Jean-Cheng; Waterman, Clare M.] NHLBI, Cell Biol & Physiol Ctr, Bethesda, MD 20892 USA.
[Han, Xuemei; Yates, John R., III] Scripps Res Inst, La Jolla, CA 92037 USA.
RP Kuo, JC (reprint author), NHLBI, Cell Biol & Physiol Ctr, Bldg 10, Bethesda, MD 20892 USA.
OI Waterman, Clare/0000-0001-6142-6775
NR 22
TC 4
Z9 4
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-165-9
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 757
BP 297
EP 323
DI 10.1007/978-1-61779-166-6_19
D2 10.1007/978-1-61779-166-6
PG 27
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BYV44
UT WOS:000300588400019
ER
PT S
AU Calderwood, SK
Prince, TL
AF Calderwood, Stuart K.
Prince, Thomas L.
BE Calderwood, SK
Prince, TL
TI Molecular Chaperones Methods and Protocols Preface
SO MOLECULAR CHAPERONES: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Editorial Material; Book Chapter
ID HEAT-SHOCK PROTEINS; STRESS; HSP70
C1 [Calderwood, Stuart K.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA.
[Prince, Thomas L.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA.
RP Calderwood, SK (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-294-6
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 787
BP VII
EP IX
D2 10.1007/978-1-61779-295-3
PG 3
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BYL18
UT WOS:000299228600001
ER
PT S
AU Zhang, Y
Chou, SD
Murshid, A
Prince, TL
Schreiner, S
Stevenson, MA
Calderwood, SK
AF Zhang, Yue
Chou, Shiuh-Dih
Murshid, Ayesha
Prince, Thomas L.
Schreiner, Sheila
Stevenson, Mary Ann
Calderwood, Stuart K.
BE Calderwood, SK
Prince, TL
TI The Role of Heat Shock Factors in Stress-Induced Transcription
SO MOLECULAR CHAPERONES: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Heat; Shock; Factor; Binding; Transcription
ID PROTEIN HSP70; GENE-EXPRESSION; BINDING-PROTEIN; C-FOS; THERMOTOLERANCE;
ACTIVATION; CELLS; YEAST; HSF1; REPRESSION
AB Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and the consequent increases in HSP gene expression in vitro and in vivo.
C1 [Zhang, Yue; Stevenson, Mary Ann; Calderwood, Stuart K.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Radiat Oncol, Boston, MA 02215 USA.
[Prince, Thomas L.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA.
RP Zhang, Y (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Radiat Oncol, Boston, MA 02215 USA.
FU NCI NIH HHS [R0-1CA094397, R01 CA047407, R01 CA077465, R01CA119045, R01
CA094397, R0-1CA047407, R01 CA119045]
NR 40
TC 3
Z9 3
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-294-6
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 787
BP 21
EP 32
DI 10.1007/978-1-61779-295-3_2
D2 10.1007/978-1-61779-295-3
PG 12
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BYL18
UT WOS:000299228600003
PM 21898224
ER
PT S
AU Wiese, T
Burns, J
Yao, JH
Summers, RM
AF Wiese, Tatjana
Burns, Joseph
Yao, Jianhua
Summers, Ronald M.
GP IEEE
TI COMPUTER-AIDED DETECTION OF SCLEROTIC BONE METASTASES IN THE SPINE USING
WATERSHED ALGORITHM AND SUPPORT VECTOR MACHINES
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE computer aided detection; bone metastasis; sclerotic lesion
AB This work presents a computer-aided detection (CAD) system to aid radiologists in finding sclerotic bone metastases in the spine on CT images. The spine is first segmented using thresholding, region growing and a vertebra template. A watershed algorithm and a merging routine segment potential lesion candidates in each two-dimensional (2-D) axial CT image. Next, overlapping 2-D detections on sequential CT slices are merged to form 3-D candidate lesions. For each of these, 30 quantitative features based on shape, density, and location are computed. After a feature filter eliminates clearly false candidates, a ground truth on 10 clinical cases segmented manually by an expert, and the features of each CAD candidate are used to train seven support vector machines. The segmentation algorithm detects 164 out of the 212 manually segmented lesions. A ten-fold cross-validation trained on these detections results in 77.4% sensitivity at an average of 9.44 false positives per case.
C1 [Wiese, Tatjana; Burns, Joseph; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA.
RP Wiese, T (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA.
NR 5
TC 3
Z9 3
U1 0
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 152
EP 155
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400036
ER
PT S
AU Wang, SJ
Anugu, V
Nguyen, T
Rose, N
Burns, J
McKenna, M
Petrick, N
Summers, RM
AF Wang, Shijun
Anugu, Vishal
Tan Nguyen
Rose, Natalie
Burns, Joseph
McKenna, Matthew
Petrick, Nicholas
Summers, Ronald M.
GP IEEE
TI FUSION OF MACHINE INTELLIGENCE AND HUMAN INTELLIGENCE FOR COLONIC POLYP
DETECTION IN CT COLONOGRAPHY
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE Computed tomographic colonography; computer aided detection; Amazon
MTurk; alpha -integration; classifier fusion
ID TOMOGRAPHIC VIRTUAL COLONOSCOPY; COMPUTER-AIDED DETECTION; FALSE
POSITIVES; REDUCTION
AB In this paper, we proposed a novel method to improve colonic polyp detection in computed tomographic colonography. Utilizing the human knowledge workers via the Amazon Mechanical Turk (MTurk) webservice, we distributed polyp detections from a computer-aided detection system (CAD) to anonymous online knowledge workers and asked them to distinguish true and false polyp candidates. We combined decisions from the CAD system (machine intelligence) and the MTurk workers (human intelligence) using alpha-integration. Preliminary experimental results indicated that the combined decisions were superior to either alone, with area under the receiver operating characteristic curve improving by 5.8% and 7.0% compared with CAD and MTurk workers alone, respectively.
C1 [Wang, Shijun; Anugu, Vishal; Tan Nguyen; Rose, Natalie; Burns, Joseph; McKenna, Matthew; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA.
[Petrick, Nicholas] U S Food & Drug Adm, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA.
[Burns, Joseph] Univ Calif, Irvine Med Ctr, Dept Radiol Sci, Orange, CA 92868 USA.
RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA.
EM rms@mail.nih.gov
FU Intramural Research Programs of the NIH Clinical Center; U.S. Food and
Drug Administration
FX This research was supported by the Intramural Research Programs of the
NIH Clinical Center and the U.S. Food and Drug Administration (NP).
NR 12
TC 7
Z9 7
U1 0
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 160
EP 164
PG 5
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400038
ER
PT S
AU Chen, M
Carass, A
Cuzzocreo, J
Bazin, PL
Reich, DS
Prince, JL
AF Chen, Min
Carass, Aaron
Cuzzocreo, Jennifer
Bazin, Pierre-Louis
Reich, Daniel S.
Prince, Jerry L.
GP IEEE
TI TOPOLOGY PRESERVING AUTOMATIC SEGMENTATION OF THE SPINAL CORD IN
MAGNETIC RESONANCE IMAGES
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE Topology-preserving segmentation; digital homeomorphism; spinal cord
segmentation; Magnetic resonance imaging; Magnetization transfer images
ID MULTIPLE-SCLEROSIS; SEMIAUTOMATIC SEGMENTATION; CT IMAGES; MODEL
AB Magnetic resonance images of the spinal cord play an important role in studying neurological diseases, particularly multiple sclerosis, where spinal cord atrophy can provide a measure of disease progression and disability. Current practices involve segmenting the spinal cord manually, which can be an inconsistent and time-consuming process. We present an automatic segmentation method for the spinal cord using a novel combination of deformable atlas based registration and topology preserving classification to address the challenges inherent to MR images of the spinal cord. Using real MR data, our method is shown to be highly accurate when compared to segmentations by manual raters. In addition, our results always maintain the correct topology of the spinal cord, therefore providing segmentations more consistent with the known anatomy.
C1 [Chen, Min; Carass, Aaron; Prince, Jerry L.] Johns Hopkins Univ, Dept ECE, Image Anal & Commun Lab, Baltimore, MD 21218 USA.
[Cuzzocreo, Jennifer; Bazin, Pierre-Louis] Johns Hopkins Univ, Lab Med Image Comp, Dept Radiol, Baltimore, MD 21218 USA.
[Reich, Daniel S.] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA.
[Chen, Min; Reich, Daniel S.] Natl Inst Neurol Disorders & Stroke, Translat Neuroradiol Unit, Bethesda, MD USA.
RP Chen, M (reprint author), Johns Hopkins Univ, Dept ECE, Image Anal & Commun Lab, Baltimore, MD 21218 USA.
EM mchen55@jhu.edu; aaron_carass@jhu.edu; pbazin1@jhmi.edu;
daniel.reich@nih.gov; prince@jhu.edu
RI Reich, Daniel/E-5701-2010;
OI Reich, Daniel/0000-0002-2628-4334; Carass, Aaron/0000-0003-4939-5085
FU Intramural Research Program of NINDS; National Multiple Sclerosis
Society
FX This work was supported by the Intramural Research Program of NINDS.
Data acquisition was supported by the National Multiple Sclerosis
Society under a Tissue Repair grant to Peter Calabresi (Johns Hopkins
University).
NR 21
TC 8
Z9 8
U1 0
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1737
EP 1740
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400398
ER
PT S
AU Yoo, TS
Hamilton, T
Hurt, DE
Caban, J
Liao, D
Chen, DT
AF Yoo, Terry S.
Hamilton, Trevor
Hurt, Darrell E.
Caban, Jesus
Liao, David
Chen, David T.
GP IEEE
TI TOWARD QUANTITATIVE X-RAY CT PHANTOMS OF METASTATIC TUMORS USING RAPID
PROTOTYPING TECHNOLOGY
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE Tomographic imaging; Computational imaging; X-ray imaging;
Three-dimensional image acquisition
ID SOLID TUMORS; RECIST; SIZE
AB We are seeking ground-truth 3D X-ray CT phantoms with gradations of Hounsfield units that are indistinguishable from scans of human subjects. We modified a 3D printer, a ZCorp Spectrum 510, adding an iodine-based contrast agent, and printed physical models using a powder which consists mainly of cellulose and cornstarch. We scanned these 3D models with a Siemens Somatom Definition AS 128-slice CT scanner. By adjusting the level of iodine within the model, we are able to achieve Hounsfield units as high as 1056, mimicking bone, and as low as -450, similar to pulmonary tissue. We demonstrate how to generate grayscale images within a 3D model that can be imaged using a CT scanner. Unlike solid tumor phantoms, these models can accurately mimic lesions with indistinct boundaries similar to metastatic disease. Our intent is to evaluate the accuracy of computer aided diagnosis systems.
C1 [Yoo, Terry S.; Hamilton, Trevor; Caban, Jesus; Liao, David; Chen, David T.] NIH, Off High Performance Comp & Commun, NLM, Bldg 10, Bethesda, MD 20892 USA.
[Hurt, Darrell E.] NIH, Off Cyber Infrastructure & Comput Biol, NIAID, Bethesda, MD 20892 USA.
RP Yoo, TS (reprint author), NIH, Off High Performance Comp & Commun, NLM, Bldg 10, Bethesda, MD 20892 USA.
FU NIH
FX This work was enabled in part by the generous help of the Radiology
Department at the Georgetown University School of Medicine, in
particular, Emmanuel Wilson and Kevin Cleary of the Georgetown ISIS
Center. We are also indebted to the NIH Summer Internship Program for
their support of two of our investigators during their brief tenure at
NIH.
NR 15
TC 5
Z9 5
U1 1
U2 6
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1770
EP 1773
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400405
ER
PT S
AU Xue, ZY
Long, LR
Antani, S
Thoma, GR
AF Xue, Zhiyun
Long, L. Rodney
Antani, Sameer
Thoma, George R.
GP IEEE
TI PATHOLOGY-BASED VERTEBRAL IMAGE RETRIEVAL
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE Content Based Image Retrieval; Spine X-ray Biomedical Database; Anterior
Osteophytes; Partial Shape Matching
AB Searching for vertebrae in a large collection of spine X-ray images that are relevant to pathology is potentially important for providing assistance to radiologists and bone morphometrists. Developing appropriate methods for such searching tasks is very challenging due to the high similarities among vertebral shapes in contrast to the subtle dissimilarities that characterize the pathology. In this paper, we target two aspects of this problem: first, we develop mathematical features that can effectively represent the biomedical characteristics of interest; second, we exploit similarity learning to enhance and try to optimize the retrieval performance. We evaluate our proposed method on an expert-annotated dataset of 856 vertebrae and demonstrate its retrieval performance by precision-recall and average-precision graphs. We also demonstrate how we have integrated our method into our Web-accessible spine X-ray image retrieval system.
C1 [Xue, Zhiyun; Long, L. Rodney; Antani, Sameer; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA.
RP Xue, ZY (reprint author), NIH, US Natl Lib Med, Bethesda, MD 20892 USA.
OI Antani, Sameer/0000-0002-0040-1387
NR 5
TC 1
Z9 1
U1 0
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1893
EP 1896
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400433
ER
PT S
AU Rahman, MM
Antani, SK
Thoma, GR
AF Rahman, Md Mahmudur
Antani, Sameer K.
Thoma, George R.
GP IEEE
TI A Biomedical Image Retrieval Framework Based on Classification-Driven
Image Filtering and Similarity Fusion
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
AB This paper presents a classification-driven biomedical image retrieval approach based on multi-class support vector machine (SVM) and uses image filtering and similarity fusion. In this framework, the probabilistic outputs of the SVM are exploited to reduce the search space for similarity matching. In addition, the predicted category of the query image is used for linear combination of similarity. The method is evaluated on a diverse collection of 5000 biomedical images of different modalities, body parts, and orientations and shows a halving in computation time (efficiency) and 10% to 15% improvement in precision at each recall level (effectiveness).
C1 [Rahman, Md Mahmudur; Antani, Sameer K.; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA.
RP Rahman, MM (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
OI Antani, Sameer/0000-0002-0040-1387
NR 9
TC 5
Z9 5
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1905
EP 1908
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400436
ER
PT S
AU Bliton, J
Yao, JH
Bi, M
Summers, RM
AF Bliton, John
Yao, Jianhua
Bi, Mark
Summers, Ronald M.
GP IEEE
TI IMPROVED 3D AUTOMATIC SEGMENTATION AND MEASUREMENT OF PLEURAL EFFUSIONS
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
AB Pleural effusions are accumulations of fluid in the pleural space, usually associated with atelectasis of the adjacent lung. We have previously presented an automated method to measure the volume of pleural effusions on chest CT images [1]. This paper presents an improved version of the same method, which adds 3D surface modeling and additional propagation of the segmentation in the inferior direction. The improved method is also more robust to noise. We compared this method to manual segmentations and the previous method by applying it to 15 chest CT scans. The new segmentation, on average, increased estimated effusion volume by 11%, bringing it closer to the expected average. In addition, the correlation between manual and automatic effusion volumes increased from .59 to .81 (p = .13), indicating a better segmentation.
C1 [Bliton, John; Yao, Jianhua; Bi, Mark; Summers, Ronald M.] NIH, Radiol & Image Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Bliton, J (reprint author), NIH, Radiol & Image Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1954
EP 1957
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400447
ER
PT S
AU Pamulapati, V
Wood, BJ
Linguraru, MG
AF Pamulapati, Vivek
Wood, Bradford J.
Linguraru, Marius George
GP IEEE
TI INTRA-HEPATIC VESSEL SEGMENTATION AND CLASSIFICATION IN MULTI-PHASE CT
USING OPTIMIZED GRAPH CUTS
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE contrast-enhanced CT; liver; hepatic vein; portal vein; segmentation;
classification; graph
ID LIVER ANATOMY; ALGORITHMS
AB The segmentation and classification of the major intrahepatic blood vessels are critical for the robust identification of the segmental anatomy of the liver. We propose a novel 4D graph-based method to segment and label the hepatic and portal veins. The algorithm uses multi-phase CT images to model the differential enhancement of the liver structures and Hessian-based vesselness likelihood to avoid the common pitfalls of graph cuts-based intrahepatic vessel segmentation. A hybrid classification step identifies the right, middle and left hepatic, and portal veins. We tested the method on CT data from nine patients and comparatively found that the new vesselness and enhancement graph costs are effective in reducing the effects of heterogeneous noise and vessel fragmentation.
C1 [Pamulapati, Vivek; Wood, Bradford J.; Linguraru, Marius George] NIH, Ctr Clin, Bethesda, MD 20892 USA.
RP Pamulapati, V (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA.
EM lingurarum@mail.nih.gov
NR 18
TC 5
Z9 5
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 1982
EP 1985
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400454
ER
PT S
AU Liu, XF
Linguraru, MG
Yao, JH
Summers, RM
AF Liu, Xiaofeng
Linguraru, Marius George
Yao, Jianhua
Summers, Ronald M.
GP IEEE
TI ABDOMINAL MULTI-ORGAN LOCALIZATION ON CONTRAST-ENHANCED CT BASED ON
MAXIMUM A POSTERIORI PROBABILITY AND MINIMUM VOLUME OVERLAP
SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO
TO MACRO
SE IEEE International Symposium on Biomedical Imaging
LA English
DT Proceedings Paper
CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From
Nano to Macro
CY MAR 30-APR 02, 2011
CL Chicago, IL
SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS)
DE contrast-enhanced CT; liver; spleen kidney; localization; maximum a
posteriori probability
ID AUTOMATED SEGMENTATION; LIVER; MODEL; ATLAS
AB Multi-organ localization is required for many automated abdominal organ analysis tasks. We recently developed an automated organ localization method, which used an MAP framework, and applied it to non-contrast CT images. This method failed to localize smaller organs such as kidneys in some image data because it did not respect the spatial relationship among multiple organs. To address the problem, we extend the framework by modeling the inter-organ spatial relations using a minimum volume overlap constraint and incorporating it into the MAP framework. The method was validated on 17 contrast-enhanced CT images and identified correctly the liver, spleen, pancreas and kidneys in all data sets. The new method is more robust to organ pose variations, computationally fast, and improved significantly the localization of kidneys.
C1 [Liu, Xiaofeng; Linguraru, Marius George; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Clin Ctr, Bethesda, MD 20892 USA.
RP Liu, XF (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Clin Ctr, Bethesda, MD 20892 USA.
EM lingurarum@mail.nih.gov
NR 16
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7928
BN 978-1-4244-4128-0
J9 I S BIOMED IMAGING
PY 2011
BP 2083
EP 2086
PG 4
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA BYH79
UT WOS:000298849400477
ER
PT J
AU Dorner, T
Giesecke, C
Lipsky, PE
AF Doerner, Thomas
Giesecke, Claudia
Lipsky, Peter E.
TI Mechanisms of B cell autoimmunity in SLE
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Review
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ADHESION MOLECULE EXPRESSION; VARIABLE
REGION GENES; HUMAN PLASMA-CELLS; PERIPHERAL-BLOOD; LYMPHOCYTE
HOMEOSTASIS; TOLERANCE CHECKPOINTS; SOMATIC HYPERMUTATION;
RHEUMATOID-ARTHRITIS; DEPLETION THERAPY
AB Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyper-reactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyperreactivity leading to polyclonal B-cell activation with disturbed activation thresholds and ineffective negative selection; (b) lack of immunoregulatory functions; (c) secondary effects of an overactive inflammatory environment, such as overactive germinal center and ectopic follicular activity; and/or (d) disturbed cytokine production by non-B immune cells. These mechanisms are not mutually exclusive and may operate to varying extents and at varying times in SLE. Phenotypic and molecular studies as well as the results of recent clinical trials have begun to provide new insights to address these possibilities. Of importance, new information has made it possible to distinguish between the contribution played by abnormalities in central checkpoints that could lead to a pre-immune repertoire enriched in autoreactive B cells, on the one hand, and the possibility that autoimmunity arises in the periphery from somatic hypermutation and abnormal selection during T cell-dependent B-cell responses on the other. There is an intriguing possibility that apoptotic material bound to the surface of follicular dendritic cells positively selects autoreactive B cells that arise from non-autoreactive B-cell precursors as a result of somatic hypermutation and thereby promotes the peripheral emergence of autoimmunity.
C1 [Doerner, Thomas; Giesecke, Claudia] Charite, Charite Ctr 12, Dept Med Rheumatol & Clin Immunol, D-10117 Berlin, Germany.
[Doerner, Thomas; Giesecke, Claudia] Deutsch Rheumaforschungszentrum, D-10117 Berlin, Germany.
[Lipsky, Peter E.] NIAMSD, NIH, Bethesda, MD 20892 USA.
RP Dorner, T (reprint author), Charite, Charite Ctr 12, Dept Med Rheumatol & Clin Immunol, D-10117 Berlin, Germany.
EM thomas.doerner@charite.de
NR 81
TC 66
Z9 69
U1 2
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-6354
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PY 2011
VL 13
IS 5
AR 243
DI 10.1186/ar3433
PG 12
WC Rheumatology
SC Rheumatology
GA 904DR
UT WOS:000301174600053
PM 22078750
ER
PT S
AU Berenson, DF
Weiss, AR
Wan, ZL
Weiss, MA
AF Berenson, Daniel F.
Weiss, Allison R.
Wan, Zhu-li
Weiss, Michael A.
GP Annals NY Acad Sci
TI Insulin analogs for the treatment of diabetes mellitus: therapeutic
applications of protein engineering
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE protein design; bottom-up; nanotechnology; zinc finger; hormone
ID ASSOCIATION PROPERTIES; SUBCUTANEOUS INJECTION; COST-EFFECTIVENESS;
RECEPTOR-BINDING; SELF-ASSOCIATION; DELIVERY SYSTEM; CONCANAVALIN-A;
ACTION PROFILE; BASAL INSULIN; NPH INSULIN
AB The engineering of insulin analogs represents a triumph of structure-based protein design. A framework has been provided by structures of insulin hexamers. Containing a zinc-coordinated trimer of dimers, such structures represent a storage form of the active insulin monomer. Initial studies focused on destabilization of subunit interfaces. Because disassembly facilitates capillary absorption, such targeted destabilization enabled development of rapid-acting insulin analogs. Converse efforts were undertaken to stabilize the insulin hexamer and promote higher-order self-assembly within the subcutaneous depot toward the goal of enhanced basal glycemic control with reduced risk of hypoglycemia. Current products either operate through isoelectric precipitation (insulin glargine, the active component of Lantus(R); Sanofi-Aventis, Paris, France) or employ an albumin-binding acyl tether (insulin detemir, the active component of Levemir(R); Novo-Nordisk, Bagsvaerd, Denmark). To further improve pharmacokinetic properties, modified approaches are presently under investigation. Novel strategies have recently been proposed based on subcutaneous supramolecular assembly coupled to (i) large-scale allosteric reorganization of the insulin hexamer (the TR transition), (ii) pH-dependent binding of zinc ions to engineered His-X-3-His sites at hexamer surfaces, or (iii) the long-range vision of glucose-responsive polymers for regulated hormone release. Such designs share with wild-type insulin and current insulin products a susceptibility to degradation above room temperature, and so their delivery, storage, and use require the infrastructure of an affluent society. Given the global dimensions of the therapeutic supply chain, we envisage that concurrent engineering of ultra-stable protein analog formulations would benefit underprivileged patients in the developing world.
C1 [Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA.
[Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Biomed Engn, Cleveland, OH 44106 USA.
[Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA.
[Berenson, Daniel F.] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.
[Weiss, Allison R.] NIDDKD, NIH, Bethesda, MD 20892 USA.
RP Weiss, MA (reprint author), Case Western Reserve Univ, Sch Med, Dept Biochem, 10900 Euclid Ave, Cleveland, OH 44106 USA.
EM Michael.Weiss@case.edu
FU NIDDK NIH HHS [R01 DK079233, R01 DK079233-04]
NR 118
TC 6
Z9 6
U1 1
U2 11
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-847-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1243
BP E40
EP E54
DI 10.1111/j.1749-6632.2012.06468.x
PG 15
WC Endocrinology & Metabolism; Multidisciplinary Sciences
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BZG28
UT WOS:000301504400002
PM 22641195
ER
PT S
AU Su, HC
Jing, H
Zhang, Q
AF Su, Helen C.
Jing, Huie
Zhang, Qian
GP Annals NY Acad Sci
TI DOCK8 deficiency
SO YEAR IN HUMAN AND MEDICAL GENETICS: INBORN ERRORS OF IMMUNITY II
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE DOCK8; hyper-IgE syndrome; combined immunodeficiency; lymphopenia
ID HYPER-IGE SYNDROME; HYPERIMMUNOGLOBULIN-E SYNDROME; STEM-CELL
TRANSPLANTATION; RAC ACTIVATOR DOCK2; CYTOKINESIS 8 DOCK8; HOMOZYGOUS
DELETIONS; STAT3 MUTATIONS; LUNG-CANCER; T-CELLS; IMMUNODEFICIENCY
AB The discovery that loss-of-function mutations in the gene DOCK8 are responsible for most forms of autosomal recessive hyper-IgE syndrome and some forms of combined immunodeficiency without elevated serum IgE has led to studies into the immunopathogenesis of this disease. In this review, we relate the clinical features of this disease to studies using patients' cells and a mouse model of Dock8 deficiency, which have revealed how DOCK8 regulates T and B cell numbers and functions. The results of these studies help to explain how the absence of DOCK8 contributes to patients' susceptibility to viral, fungal, and bacterial infections. However, unanswered questions remain regarding how the absence of DOCK8 also leads to high IgE and allergic disease, predisposition for malignancy, and unusual clinical features, such as CNS abnormalities and autoimmunity, observed in some patients.
C1 [Su, Helen C.; Jing, Huie; Zhang, Qian] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA.
RP Su, HC (reprint author), Bldg 10CRC,Room 5W3940,10CRC Ctr Dr,MSC 1456, Bethesda, MD 20892 USA.
EM hsu@niaid.nih.gov
RI Su, Helen/H-9541-2015;
OI Su, Helen/0000-0002-5582-9110; Zhang, Qian/0000-0002-9040-3289
FU Intramural NIH HHS
NR 51
TC 37
Z9 37
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-851-8
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1246
BP 26
EP 33
DI 10.1111/j.1749-6632.2011.06295.x
PG 8
WC Genetics & Heredity; Multidisciplinary Sciences
SC Genetics & Heredity; Science & Technology - Other Topics
GA BZG57
UT WOS:000301519900003
PM 22236427
ER
PT J
AU Deuster, PA
Kim-Dorner, SJ
Remaley, AT
Poth, M
AF Deuster, Patricia A.
Kim-Dorner, Su Jong
Remaley, Alan T.
Poth, Merrily
TI Allostatic Load and Health Status of African Americans and Whites
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE aerobic fitness; body fat; depression; exercise; insulin; sleep habits
ID CUMULATIVE BIOLOGICAL RISK; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
NATIONAL SAMPLE; SOCIAL SUPPORT; NHANES-III; STRESS; CORTISOL; ADULTS;
DISPARITIES
AB Objectives: To compare health risks in 84 healthy African American and 45 white men and women after calculating allostatic load (AL) from biologic, psychosocial, and behavioral measures. Methods: Participants (18-45 years) ranging in weight from normal to obese and without hypertension or diabetes. Fitness, body fat, CRP, mood, social support, blood pressure, sleep and exercise habits, coping, and insulin responses were dichotomized as low/high risk and summed for AL. Results: African Americans (3.4 +/- 1.9) had significantly higher AL than that of whites (2.4 +/- 1.9; P<0.05). Significantly more African Americans had AL >= 3 (67.9%) than did whites (48.9%). Conclusions: Identifying cumulative AL may help identify and address the underpinnings of health disparities in African Americans.
C1 [Deuster, Patricia A.; Kim-Dorner, Su Jong] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
[Remaley, Alan T.] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
RP Deuster, PA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
EM pdeuster@usuhs.mil; sjkim@usuhs.mil
RI Deuster, Patricia/G-3838-2015
OI Deuster, Patricia/0000-0002-7895-0888
NR 65
TC 8
Z9 8
U1 7
U2 12
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PY 2011
VL 35
IS 6
BP 641
EP 653
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 909MD
UT WOS:000301567700001
PM 22251756
ER
PT J
AU Kaufman, AR
Waters, EA
Parascandola, M
Augustson, EM
Bansal-Travers, M
Hyland, A
Cummings, KM
AF Kaufman, Annette R.
Waters, Erika A.
Parascandola, Mark
Augustson, Erik M.
Bansal-Travers, Maansi
Hyland, Andrew
Cummings, K. Michael
TI Food and Drug Administration Evaluation and Cigarette Smoking Risk
Perceptions
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE Food and Drug Administration; evaluation; regulation; smoking; risk
ID LIGHT CIGARETTES; SMOKERS; PRODUCTS
AB Objectives: To examine the relationship between a belief about Food and Drug Administration (FDA) safety evaluation of cigarettes and smoking risk perceptions. Methods: A nationally representative, random-digit-dialed telephone survey of 1046 adult current cigarette smokers. Results: Smokers reporting that the FDA does not evaluate cigarettes for safety (46.1%), exhibited greater comprehension of the health risks of smoking and were more likely (48.5%) than other participants (33.6%) to report quit intentions. Risk perceptions partially mediated the relationship between FDA evaluation belief and quit intentions. Conclusions: These findings highlight the need for proactive, effective communication to the public about the aims of new tobacco product regulations.
C1 [Kaufman, Annette R.] NCI, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Waters, Erika A.] Washington Univ, Sch Med, Div Publ Hlth Sci, St Louis, MO USA.
[Parascandola, Mark; Augustson, Erik M.] NCI, Tobacco Control Res Branch, DCCPS, Bethesda, MD 20892 USA.
[Bansal-Travers, Maansi; Hyland, Andrew; Cummings, K. Michael] Roswell Pk Canc Inst, Dept Hlth Behav, Buffalo, NY USA.
RP Kaufman, AR (reprint author), NCI, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
EM kaufmana@mail.nih.gov
OI Waters, Erika/0000-0001-7402-0133
FU Intramural NIH HHS [Z99 CA999999]; NCI NIH HHS [CA 16056-26, P30
CA016056]
NR 27
TC 5
Z9 5
U1 1
U2 4
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PY 2011
VL 35
IS 6
BP 766
EP 776
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 909MD
UT WOS:000301567700012
PM 22251767
ER
PT S
AU Stokes, WS
AF Stokes, William S.
GP Annals NY Acad Sci
TI Best practices for the use of animals in toxicological research and
testing
SO ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on Animal Models and Their Value in Predicting Drug Efficacy
and Toxicity
CY SEP 15-16, 2011
CL New York, NY
DE toxicology; animal welfare; animal models; alternative methods
AB Animal models serve an important role in assessing preclinical safety and efficacy of new medicines and vaccines; however, such assessments can involve significant pain and distress and large numbers of animals. Best practice approaches seek to enhance animal well-being, minimize or avoid pain and distress, and use fewer animals. Advances in science and technology are providing opportunities for improved mechanism-based models and integrated safety assessments that will support improved animal welfare and reduce animal use.
C1 Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA.
RP Stokes, WS (reprint author), Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, POB 12233,Maildrop K2-16,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM Stokes@niehs.nih.gov
NR 9
TC 8
Z9 8
U1 2
U2 11
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-875-4
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1245
BP 17
EP 20
DI 10.1111/j.1749-6632.2011.06334.x
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA BZE80
UT WOS:000301289400007
PM 22211968
ER
PT J
AU O'Hanlon, TP
Li, ZY
Gan, L
Gourley, MF
Rider, LG
Miller, FW
AF O'Hanlon, Terrance P.
Li, Zhuoyan
Gan, Lu
Gourley, Mark F.
Rider, Lisa G.
Miller, Frederick W.
TI Plasma proteomic profiles from disease-discordant monozygotic twins
suggest that molecular pathways are shared in multiple systemic
autoimmune diseases
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
DE autoimmunity; inflammation; human; proteome
ID RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; MASS-SPECTROMETRY;
PARAOXONASE 1; SYNOVIAL-FLUID; PON1 ACTIVITY; RANDOM FOREST; BIOMARKERS;
CLASSIFICATION; POLYMORPHISMS
AB Introduction: Although systemic autoimmune diseases (SAID) share many clinical and laboratory features, whether they also share some common features of pathogenesis remains unclear. We assessed plasma proteomic profiles among different SAID for evidence of common molecular pathways that could provide insights into pathogenic mechanisms shared by these diseases.
Methods: Differential quantitative proteomic analyses (one-dimensional reverse-phase liquid chromatography-mass spectrometry) were performed to assess patterns of plasma protein expression. Monozygotic twins (four pairs discordant for systemic lupus erythematosus, four pairs discordant for juvenile idiopathic arthritis and two pairs discordant for juvenile dermatomyositis) were studied to minimize polymorphic gene effects. Comparisons were also made to 10 unrelated, matched controls.
Results: Multiple plasma proteins, including acute phase reactants, structural proteins, immune response proteins, coagulation and transcriptional factors, were differentially expressed similarly among the different SAID studied. Multivariate Random Forest modeling identified seven proteins whose combined altered expression levels effectively segregated affected vs. unaffected twins. Among these seven proteins, four were also identified in univariate analyses of proteomic data (syntaxin 17, alpha-glucosidase, paraoxonase 1, and the sixth component of complement). Molecular pathway modeling indicated that these factors may be integrated through interactions with a candidate plasma biomarker, PON1 and the pro-inflammatory cytokine IL-6.
Conclusions: Together, these data suggest that different SAID may share common alterations of plasma protein expression and molecular pathways. An understanding of the mechanisms leading to the altered plasma proteomes common among these SAID may provide useful insights into their pathogeneses.
C1 [O'Hanlon, Terrance P.; Li, Zhuoyan; Gan, Lu; Rider, Lisa G.; Miller, Frederick W.] NIEHS, Environm Autoimmun Grp, NIH, DHHS, Bethesda, MD 20892 USA.
[Gourley, Mark F.] Natl Inst Arthrit & Musculoskeletal Dis, NIH, DHHS, Bethesda, MD 20892 USA.
RP O'Hanlon, TP (reprint author), NIEHS, Environm Autoimmun Grp, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM ohanlont@niehs.nih.gov
RI Gan, Lu/L-5395-2014;
OI Rider, Lisa/0000-0002-6912-2458; Miller, Frederick/0000-0003-2831-9593
FU National Institute of Environmental Health Sciences [Z01 ES101074]; NIH
FX This work was supported by the intramural research program project Z01
ES101074 of the National Institute of Environmental Health Sciences,
NIH.
NR 47
TC 7
Z9 7
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PY 2011
VL 13
IS 6
AR R181
DI 10.1186/ar3506
PG 13
WC Rheumatology
SC Rheumatology
GA 904EB
UT WOS:000301175700001
PM 22044644
ER
PT S
AU Appelman, HD
Umar, A
Orlando, RC
Sontag, SJ
Nandurkar, S
El-Zimaity, H
Lanas, A
Parise, P
Lambert, R
Shields, HM
AF Appelman, Henry D.
Umar, Asad
Orlando, Roy C.
Sontag, Stephen J.
Nandurkar, Sanjay
El-Zimaity, Hala
Lanas, Angel
Parise, Paolo
Lambert, Rene
Shields, Helen M.
BA Giuli, R
BF Giuli, R
TI Barrett's esophagus: natural history
SO BARRETT'S ESOPHAGUS: THE 10TH OESO WORLD CONGRESS PROCEEDINGS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 10th World Congress of the World Organization for Specialized Studies on
Diseases of the Esophagus (OESO)
CY AUG 28-31, 2010
CL Boston, MA
DE reflux; adenocarcinoma; CDX2; dilated intercellular spaces; bile salts;
high-grade dysplasia; Barrett's esophagus; biopsy protocol;
adenocarcinoma; gastric atrophy; H. pylori; GERD; endoscopic grading
system; Cag A-postive strain; metaplasia; laparoscopic surgery; high
resolution endoscopy; narrow band imaging; trimodal technology; bimodal
protocol; esophageal metaplasia; radiofrequency ablation; endoscopic
mucosal resection; interobserver reproducibility
ID HELICOBACTER-PYLORI INFECTION; HIGH-GRADE DYSPLASIA;
GASTROESOPHAGEAL-REFLUX DISEASE; COLUMNAR-LINED ESOPHAGUS; ANTIREFLUX
SURGERY; INTESTINAL METAPLASIA; SURGICAL-TREATMENT; UNITED-STATES;
CANCER; ADENOCARCINOMA
AB The following on the natural history of Barrett's esophagus (BE) includes commentary on histological sequences of the development of Barrett mucosa; the transformation of esophageal cells from squamous to columnar phenotype; the stages of natural history of dysplasia; the difficulties of predicting progression of dysplasia to adenocarcinoma; the preferable biopsy protocols; the role of Helicobacter pylori infection and gastric atrophy in the risk of BE; the value of decrease of proton pump inhibitor efficacy following eradication of H. pylori; the place of antireflux surgery in the natural history of BE; the newest procedures for the endoscopic detection of early neoplasia; and the essential importance of a good understanding of the natural history for the best management of high-grade dysplasia.
C1 [Appelman, Henry D.] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.
[Umar, Asad] NCI, Canc Prevent Div, Rockville, MD USA.
[Orlando, Roy C.] Univ N Carolina, Sch Med, Dept Cell & Mol Physiol, Chapel Hill, NC USA.
[Sontag, Stephen J.] Edward Hines Jr VA Hosp, Hines, IL 60141 USA.
[Nandurkar, Sanjay] Box Hill Hosp, Dept Gastroenterol, Box Hill, Vic, Australia.
[El-Zimaity, Hala] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada.
[Lanas, Angel] Univ Zaragoza, CIBERehd, Aragon Hlth Res Inst, Dept Digest Dis, Zaragoza, Spain.
[Lambert, Rene] Reg Referal Ctr Esophageal Pathol, Dept Gen Surg 4, Pisa, Italy.
[Lambert, Rene] Int Agcy Res Canc, F-69372 Lyon, France.
[Shields, Helen M.] Harvard Univ, Sch Med, Div Gastroenterol, Boston, MA USA.
Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
RP Appelman, HD (reprint author), Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.
NR 56
TC 7
Z9 7
U1 0
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-829-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1232
BP 292
EP 308
DI 10.1111/j.1749-6632.2011.06057.x
PG 17
WC Gastroenterology & Hepatology; Multidisciplinary Sciences
SC Gastroenterology & Hepatology; Science & Technology - Other Topics
GA BZD71
UT WOS:000301188400017
PM 21950819
ER
PT J
AU Mulligan, AM
Couch, FJ
Barrowdale, D
Domchek, SM
Eccles, D
Nevanlinna, H
Ramus, SJ
Robson, M
Sherman, M
Spurdle, AB
Wappenschmidt, B
Lee, A
McGuffog, L
Healey, S
Sinilnikova, OM
Janavicius, R
Hansen, TV
Nielsen, FC
Ejlertsen, B
Osorio, A
Munoz-Repeto, I
Duran, M
Godino, J
Pertesi, M
Benitez, J
Peterlongo, P
Manoukian, S
Peissel, B
Zaffaroni, D
Cattaneo, E
Bonanni, B
Viel, A
Pasini, B
Papi, L
Ottini, L
Savarese, A
Bernard, L
Radice, P
Hamann, U
Verheus, M
Meijers-Heijboer, HEJ
Wijnen, J
Garcia, EBG
Nelen, MR
Kets, CM
Seynaeve, C
Tilanus-Linthorst, MMA
van der Luijt, RB
van Os, T
Rookus, M
Frost, D
Jones, JL
Evans, DG
Lalloo, F
Eeles, R
Izatt, L
Adlard, J
Davidson, R
Cook, J
Donaldson, A
Dorkins, H
Gregory, H
Eason, J
Houghton, C
Barwell, J
Side, LE
McCann, E
Murray, A
Peock, S
Godwin, AK
Schmutzler, RK
Rhiem, K
Engel, C
Meindl, A
Ruehl, I
Arnold, N
Niederacher, D
Sutter, C
Deissler, H
Gadzicki, D
Kast, K
Preisler-Adams, S
Varon-Mateeva, R
Schoenbuchner, I
Fiebig, B
Heinritz, W
Schafer, D
Gevensleben, H
Caux-Moncoutier, V
Fassy-Colcombet, M
Cornelis, F
Mazoyer, S
Leone, M
Boutry-Kryza, N
Hardouin, A
Berthet, P
Muller, D
Fricker, JP
Mortemousque, I
Pujol, P
Coupier, I
Lebrun, M
Kientz, C
Longy, M
Sevenet, N
Stoppa-Lyonnet, D
Isaacs, C
Caldes, T
de la Hoya, M
Heikkinen, T
Aittomaki, K
Blanco, I
Lazaro, C
Barkardottir, RB
Soucy, P
Dumont, M
Simard, J
Montagna, M
Tognazzo, S
D'Andrea, E
Fox, S
Yan, M
Rebbeck, T
Olopade, OI
Weitzel, JN
Lynch, HT
Ganz, PA
Tomlinson, GE
Wang, XS
Fredericksen, Z
Pankratz, VS
Lindor, NM
Szabo, C
Offit, K
Sakr, R
Gaudet, M
Bhatia, J
Kauff, N
Singer, CF
Tea, MK
Gschwantler-Kaulich, D
Fink-Retter, A
Mai, PL
Greene, MH
Imyanitov, E
O'Malley, FP
Ozcelik, H
Glendon, G
Toland, AE
Gerdes, AM
Thomassen, M
Kruse, TA
Jensen, UB
Skytte, AB
Caligo, MA
Soller, M
Henriksson, K
Wachenfeldt, V
Arver, B
Stenmark-Askmalm, M
Karlsson, P
Ding, YC
Neuhausen, SL
Beattie, M
Pharoah, PDP
Moysich, KB
Nathanson, KL
Karlan, BY
Gross, J
John, EM
Daly, MB
Buys, SM
Southey, MC
Hopper, JL
Terry, MB
Chung, W
Miron, AF
Goldgar, D
Chenevix-Trench, G
Easton, DF
Andrulis, IL
Antoniou, AC
AF Mulligan, Anna Marie
Couch, Fergus J.
Barrowdale, Daniel
Domchek, Susan M.
Eccles, Diana
Nevanlinna, Heli
Ramus, Susan J.
Robson, Mark
Sherman, Mark
Spurdle, Amanda B.
Wappenschmidt, Barbara
Lee, Andrew
McGuffog, Lesley
Healey, Sue
Sinilnikova, Olga M.
Janavicius, Ramunas
Hansen, Thomas V. O.
Nielsen, Finn C.
Ejlertsen, Bent
Osorio, Ana
Munoz-Repeto, Ivan
Duran, Mercedes
Godino, Javier
Pertesi, Maroulio
Benitez, Javier
Peterlongo, Paolo
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Cattaneo, Elisa
Bonanni, Bernardo
Viel, Alessandra
Pasini, Barbara
Papi, Laura
Ottini, Laura
Savarese, Antonella
Bernard, Loris
Radice, Paolo
Hamann, Ute
Verheus, Martijn
Meijers-Heijboer, Hanne E. J.
Wijnen, Juul
Garcia, Encarna B. Gomez
Nelen, Marcel R.
Kets, C. Marleen
Seynaeve, Caroline
Tilanus-Linthorst, Madeleine M. A.
van der Luijt, Rob B.
van Os, Theo
Rookus, Matti
Frost, Debra
Jones, J. Louise
Evans, D. Gareth
Lalloo, Fiona
Eeles, Ros
Izatt, Louise
Adlard, Julian
Davidson, Rosemarie
Cook, Jackie
Donaldson, Alan
Dorkins, Huw
Gregory, Helen
Eason, Jacqueline
Houghton, Catherine
Barwell, Julian
Side, Lucy E.
McCann, Emma
Murray, Alex
Peock, Susan
Godwin, Andrew K.
Schmutzler, Rita K.
Rhiem, Kerstin
Engel, Christoph
Meindl, Alfons
Ruehl, Ina
Arnold, Norbert
Niederacher, Dieter
Sutter, Christian
Deissler, Helmut
Gadzicki, Dorothea
Kast, Karin
Preisler-Adams, Sabine
Varon-Mateeva, Raymonda
Schoenbuchner, Ines
Fiebig, Britta
Heinritz, Wolfram
Schaefer, Dieter
Gevensleben, Heidrun
Caux-Moncoutier, Virginie
Fassy-Colcombet, Marion
Cornelis, Francois
Mazoyer, Sylvie
Leone, Melanie
Boutry-Kryza, Nadia
Hardouin, Agnes
Berthet, Pascaline
Muller, Daniele
Fricker, Jean-Pierre
Mortemousque, Isabelle
Pujol, Pascal
Coupier, Isabelle
Lebrun, Marine
Kientz, Caroline
Longy, Michel
Sevenet, Nicolas
Stoppa-Lyonnet, Dominique
Isaacs, Claudine
Caldes, Trinidad
de la Hoya, Miguel
Heikkinen, Tuomas
Aittomaki, Kristiina
Blanco, Ignacio
Lazaro, Conxi
Barkardottir, Rosa B.
Soucy, Penny
Dumont, Martine
Simard, Jacques
Montagna, Marco
Tognazzo, Silvia
D'Andrea, Emma
Fox, Stephen
Yan, Max
Rebbeck, Tim
Olopade, Olufunmilayo I.
Weitzel, Jeffrey N.
Lynch, Henry T.
Ganz, Patricia A.
Tomlinson, Gail E.
Wang, Xianshu
Fredericksen, Zachary
Pankratz, Vernon S.
Lindor, Noralane M.
Szabo, Csilla
Offit, Kenneth
Sakr, Rita
Gaudet, Mia
Bhatia, Jasmine
Kauff, Noah
Singer, Christian F.
Tea, Muy-Kheng
Gschwantler-Kaulich, Daphne
Fink-Retter, Anneliese
Mai, Phuong L.
Greene, Mark H.
Imyanitov, Evgeny
O'Malley, Frances P.
Ozcelik, Hilmi
Glendon, Gordon
Toland, Amanda E.
Gerdes, Anne-Marie
Thomassen, Mads
Kruse, Torben A.
Jensen, Uffe Birk
Skytte, Anne-Bine
Caligo, Maria A.
Soller, Maria
Henriksson, Karin
Wachenfeldt, von Anna
Arver, Brita
Stenmark-Askmalm, Marie
Karlsson, Per
Ding, Yuan Chun
Neuhausen, Susan L.
Beattie, Mary
Pharoah, Paul D. P.
Moysich, Kirsten B.
Nathanson, Katherine L.
Karlan, Beth Y.
Gross, Jenny
John, Esther M.
Daly, Mary B.
Buys, Saundra M.
Southey, Melissa C.
Hopper, John L.
Terry, Mary Beth
Chung, Wendy
Miron, Alexander F.
Goldgar, David
Chenevix-Trench, Georgia
Easton, Douglas F.
Andrulis, Irene L.
Antoniou, Antonis C.
CA Breast Canc Family Registry
EMBRACE
GEMO Study Collaborators
HEBON
kConFab Investigators
Ontario Canc Genetics Network
SWE-BRCA
CIMBA
TI Common breast cancer susceptibility alleles are associated with tumour
subtypes in BRCA1 and BRCA2 mutation carriers: results from the
Consortium of Investigators of Modifiers of BRCA1/2
SO BREAST CANCER RESEARCH
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; ESTROGEN-RECEPTOR; GENETIC SUSCEPTIBILITY;
CONFER SUSCEPTIBILITY; RISK PREDICTION; OVARIAN-CANCER; POPULATION;
LOCI; VARIANTS; PHENOTYPE
AB Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.
Methods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach.
Results: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 x 10(-6)). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status.
Conclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.
C1 [Mulligan, Anna Marie; Andrulis, Irene L.] Univ Toronto, Dept Lab Med & Pathobiol, Canc Care Ontario, Toronto, ON M5S 1A8, Canada.
[Mulligan, Anna Marie; O'Malley, Frances P.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Lab Med, Toronto, ON M5B 1W8, Canada.
[Mulligan, Anna Marie; O'Malley, Frances P.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada.
[Couch, Fergus J.; Wang, Xianshu] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
[Barrowdale, Daniel; Lee, Andrew; McGuffog, Lesley; Frost, Debra; Peock, Susan; Easton, Douglas F.; Antoniou, Antonis C.; EMBRACE] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.
[Domchek, Susan M.; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, Philadelphia, PA 19104 USA.
[Eccles, Diana] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Fac Med, Southampton SO16 6YD, Hants, England.
[Nevanlinna, Heli; Heikkinen, Tuomas] Univ Helsinki, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland.
[Aittomaki, Kristiina] Univ Helsinki, Cent Hosp, Dept Clin Genet, FIN-00290 Helsinki, Finland.
[Ramus, Susan J.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
[Robson, Mark; Offit, Kenneth; Sakr, Rita; Bhatia, Jasmine; Kauff, Noah] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
[Robson, Mark; Offit, Kenneth; Sakr, Rita; Bhatia, Jasmine; Kauff, Noah] Weill Cornell Med Coll, New York, NY USA.
[Sherman, Mark] NCI, Div Canc Epidemiol & Genet, Hormonal & Reprod Epidemiol Branch, Rockville, MD 20852 USA.
[Spurdle, Amanda B.; Healey, Sue; Chenevix-Trench, Georgia] Queensland Inst Med Res, Herston, Qld 4006, Australia.
[Wappenschmidt, Barbara; Schmutzler, Rita K.; Rhiem, Kerstin] Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, D-50931 Cologne, Germany.
[Wappenschmidt, Barbara; Schmutzler, Rita K.; Rhiem, Kerstin] Univ Hosp Cologne, Ctr Integrated Oncol, D-50931 Cologne, Germany.
[Sinilnikova, Olga M.; Leone, Melanie; Boutry-Kryza, Nadia] Ctr Hosp Univ Lyon Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, F-69373 Lyon, France.
[Sinilnikova, Olga M.; Mazoyer, Sylvie] Univ Lyon 1, Canc Res Ctr Lyon, CNRS, INSERM,U1052,UMR5286, F-69373 Lyon, France.
[Janavicius, Ramunas] Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, LT-08661 Vilnius, Lithuania.
[Janavicius, Ramunas] State Res Inst Innovat Med Ctr, LT-01102 Vilnius, Lithuania.
[Hansen, Thomas V. O.; Nielsen, Finn C.] Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, DK-2100 Copenhagen, Denmark.
[Ejlertsen, Bent] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark.
[Osorio, Ana; Munoz-Repeto, Ivan; Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid 28029, Spain.
[Osorio, Ana; Munoz-Repeto, Ivan; Benitez, Javier] Spanish Network Rare Dis CIBERER, Barcelona, Spain.
[Duran, Mercedes] Univ Valladolid, IBGM UVA, Inst Biol & Mol Genet, Valladolid 47003, Spain.
[Godino, Javier] Hosp Clin Univ Lozano Blesa, Inst Invest Sanitaria Aragon IIS, Zaragoza 50009, Spain.
[Pertesi, Maroulio] Natl Ctr Sci Res Demokritos, IRRP, Mol Diagnost Lab, Athens 15310, Greece.
[Peterlongo, Paolo; Radice, Paolo] Fdn IRCCS Ist Nazl Tumouri INT, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, I-20133 Milan, Italy.
[Peterlongo, Paolo; Radice, Paolo] Fdn Ist FIRC Oncol Mol, IFOM, I-20139 Milan, Italy.
[Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Cattaneo, Elisa] Fdn IRCCS Ist Nazl Tumouri INT, Dept Prevent & Predict Med, Unit Med Genet, I-20133 Milan, Italy.
[Bonanni, Bernardo] Ist Europeo Oncol, Div Canc Prevent & Genet, I-20141 Milan, Italy.
[Viel, Alessandra] IRCCS, Ctr Riferimento Oncol, Unit Expt Oncol 1, Aviano, PN, Italy.
[Pasini, Barbara] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy.
[Papi, Laura] Univ Florence, Dept Clin Physiopathol, Med Genet Unit, Florence, Italy.
[Ottini, Laura] Univ Roma La Sapienza, Dept Mol Med, Rome, Italy.
[Savarese, Antonella] Regina Elena Inst Canc Res, Div Med Oncol, Rome, Italy.
[Bernard, Loris] Ist Europeo Oncol, Dept Expt Oncol, Milan, Italy.
[Bernard, Loris] Consortium Genom Technol Cogentech, Milan, Italy.
[Hamann, Ute] DKFZ, Heidelberg, Germany.
[Verheus, Martijn; Rookus, Matti] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands.
[Meijers-Heijboer, Hanne E. J.] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands.
[Wijnen, Juul] Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands.
[Wijnen, Juul] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands.
[Garcia, Encarna B. Gomez] MUMC, Sch Oncol & Dev Biol, Dept Clin Genet, Maastricht, Netherlands.
[Garcia, Encarna B. Gomez] MUMC, Sch Oncol & Dev Biol, GROW, Maastricht, Netherlands.
[Nelen, Marcel R.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 849, NL-6500 HB Nijmegen, Netherlands.
[Kets, C. Marleen] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 836, NL-6500 HB Nijmegen, Netherlands.
[Seynaeve, Caroline] Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands.
[Tilanus-Linthorst, Madeleine M. A.] Erasmus Univ, Med Ctr, Family Canc Clin, Dept Surg Oncol, Rotterdam, Netherlands.
[van der Luijt, Rob B.] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.
[van Os, Theo] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands.
[Jones, J. Louise] Queen Mary Univ London, Ctr Tumour Biol, Barts Canc Inst, London, England.
[Evans, D. Gareth; Lalloo, Fiona] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
[Eeles, Ros] Inst Canc Res, Oncogenet Team, London, England.
[Eeles, Ros] Royal Marsden NHS Fdn Trust, London, England.
[Izatt, Louise] Guys & St Thomas NHS Fdn Trust, London, England.
[Adlard, Julian] Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England.
[Davidson, Rosemarie] Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland.
[Cook, Jackie] Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England.
[Donaldson, Alan] St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England.
[Dorkins, Huw] Kennedy Galton Ctr, NW Thames Reg Genet Serv, Harrow, Middx, England.
[Gregory, Helen] NHS Grampian, N Scotland Reg Genet Serv, Aberdeen, Scotland.
[Gregory, Helen] Univ Aberdeen, Aberdeen, Scotland.
[Eason, Jacqueline] Nottingham Univ Hosp NHS Trust, Nottingham Clin Genet Serv, Nottingham, England.
[Houghton, Catherine] Liverpool Womens NHS Fdn Trust, Cheshire & Merseyside Clin Genet Serv, Liverpool, Merseyside, England.
[Barwell, Julian] Univ Hosp Leicester NHS Trust, Leicestershire Clin Genet Serv, Leicester, Leics, England.
[Side, Lucy E.] Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England.
[McCann, Emma] Glan Clwyd Gen Hosp, All Wales Med Genet Serv, Rhyl, Denbigh, Wales.
[Murray, Alex] Singleton Hosp, All Wales Med Genet Serv, Swansea SA2 8QA, W Glam, Wales.
[Godwin, Andrew K.] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA.
[Engel, Christoph] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.
[Meindl, Alfons] Tech Univ Munich, Klinikum Rechts Isar, Div Tumour Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany.
[Ruehl, Ina] Univ Munich, Dept Obstet & Gynaecol, Munich, Germany.
[Arnold, Norbert] Univ Kiel, Univ Hosp Schleswig Holstein UKSH, Dept Obstet & Gynaecol, Kiel, Germany.
[Niederacher, Dieter] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-40225 Dusseldorf, Germany.
[Sutter, Christian] Univ Heidelberg Hosp, Dept Human Genet, Inst Human Genet, Heidelberg, Germany.
[Deissler, Helmut] Univ Hosp, Dept Obstet & Gynaecol, Ulm, Germany.
[Gadzicki, Dorothea] Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany.
[Kast, Karin] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, D-01062 Dresden, Germany.
[Preisler-Adams, Sabine] Univ Munster, Inst Human Genet, D-4400 Munster, Germany.
[Varon-Mateeva, Raymonda] Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany.
[Schoenbuchner, Ines] Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, D-97070 Wurzburg, Germany.
[Fiebig, Britta] Univ Regensburg, Inst Human Genet, D-8400 Regensburg, Germany.
[Heinritz, Wolfram] Univ Leipzig, Inst Human Genet, Leipzig, Germany.
[Schaefer, Dieter] Univ Hosp, Inst Human Genet, Frankfurt, Germany.
[Gevensleben, Heidrun] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London, England.
[Caux-Moncoutier, Virginie; Fassy-Colcombet, Marion; Stoppa-Lyonnet, Dominique] Inst Curie, Serv Genet Oncol, Paris, France.
[Cornelis, Francois] Avicenne Hosp, AP HP, Genet Unit, Paris, France.
[Cornelis, Francois] Sud Francilien Hosp, Evry, France.
[Cornelis, Francois] Univ Hosp, Clermont Ferrand, France.
[Hardouin, Agnes; Berthet, Pascaline] Ctr Francois Baclesse, F-14021 Caen, France.
[Muller, Daniele; Fricker, Jean-Pierre] CLCC Paul Strauss, Unite Oncogenet, Strasbourg, France.
[Mortemousque, Isabelle] CHU Bretonneau, Serv Genet, F-37044 Tours, France.
[Pujol, Pascal; Coupier, Isabelle] CHU Amaud de Villeneuve, Unite Oncogenet, Montpellier, France.
[Lebrun, Marine; Kientz, Caroline] Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France.
[Longy, Michel; Sevenet, Nicolas] Univ Bordeaux, Inst Bergonie, INSERM, Canc Genet Unit,U916, Bordeaux, France.
[Stoppa-Lyonnet, Dominique] Inst Curie, INSERM, Unite U830, Paris, France.
[Stoppa-Lyonnet, Dominique] Univ Paris 05, Fac Med, Paris, France.
[Isaacs, Claudine] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA.
[Caldes, Trinidad; de la Hoya, Miguel] Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain.
[Blanco, Ignacio; Lazaro, Conxi] Hosp Duran i Reynals Bellvitge Biomed Res Inst ID, Inst Catala Oncol, Hereditary Canc Program, Barcelona, Spain.
[Barkardottir, Rosa B.] Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland.
[Barkardottir, Rosa B.] Univ Iceland, Fac Med, Reykjavik, Iceland.
[Soucy, Penny; Dumont, Martine; Simard, Jacques] CHU Quebec, Canc Genom Lab, Quebec City, PQ, Canada.
[Simard, Jacques] Univ Laval, Fac Med, Dept Mol Med, Canada Res Chair Oncogenet, Quebec City, PQ G1K 7P4, Canada.
[Montagna, Marco; Tognazzo, Silvia] Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, I-35128 Padua, Italy.
[D'Andrea, Emma] Univ Padua, Dept Oncol & Surg Sci, I-35128 Padua, Italy.
[Fox, Stephen; kConFab Investigators] Peter MacCallum Canc Ctr, Melbourne, Vic 3052, Australia.
[Yan, Max] Prince Wales Hosp, Dept Anat Pathol, Randwick, NSW 2031, Australia.
[Rebbeck, Tim] Abramson Canc Ctr, Philadelphia, PA USA.
[Rebbeck, Tim] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Olopade, Olufunmilayo I.] Univ Chicago, Chicago, IL 60637 USA.
[Weitzel, Jeffrey N.] City Hope Natl Med Ctr, Beckman Res Inst, City Hope Comprehens Canc Ctr, Duarte, CA USA.
[Weitzel, Jeffrey N.; Ding, Yuan Chun; Neuhausen, Susan L.] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
[Lynch, Henry T.] Creighton Univ, Dept Med, Omaha, NE 68178 USA.
[Lynch, Henry T.] Creighton Univ, Dept Prevent Med & Publ Hlth, Omaha, NE 68178 USA.
[Ganz, Patricia A.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA.
[Tomlinson, Gail E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA.
[Tomlinson, Gail E.] Univ Texas SW Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA.
[Tomlinson, Gail E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA.
[Fredericksen, Zachary; Pankratz, Vernon S.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
[Lindor, Noralane M.] Mayo Clin, Dept Med Genet, Rochester, MN USA.
[Szabo, Csilla] Univ Delaware, Newark, DE USA.
[Gaudet, Mia] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
[Singer, Christian F.; Tea, Muy-Kheng; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese] Med Univ Vienna, Dept Obstet Gynaecol, Vienna, Austria.
[Singer, Christian F.; Tea, Muy-Kheng; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese] Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria.
[Mai, Phuong L.; Greene, Mark H.] US Natl Canc Inst, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Imyanitov, Evgeny] NN Petrov Inst Oncol, Oncol Mol Lab, St Petersburg, Russia.
[Ozcelik, Hilmi; Andrulis, Irene L.] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Andrulis, Irene L.] Univ Toronto, Canc Care Ontario, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.
[Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol, Columbus, OH 43210 USA.
[Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Immunol & Med Genet, Columbus, OH 43210 USA.
[Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Columbus, OH 43210 USA.
[Gerdes, Anne-Marie] Univ Copenhagen, Rigshosp, DK-2100 Copenhagen, Denmark.
[Thomassen, Mads; Kruse, Torben A.] Odense Univ Hosp, DK-5000 Odense, Denmark.
[Jensen, Uffe Birk] Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark.
[Skytte, Anne-Bine] Vejle Hosp, Vejle, Denmark.
[Caligo, Maria A.] Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy.
[Caligo, Maria A.] Univ Hosp Pisa, Pisa, Italy.
[Soller, Maria] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden.
[Henriksson, Karin] Univ Lund Hosp, Ctr Oncol, S-22185 Lund, Sweden.
[Wachenfeldt, von Anna; Arver, Brita] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
[Stenmark-Askmalm, Marie] Linkoping Univ, Dept Clin & Expt Med, Div Clin Genet, Linkoping, Sweden.
[Karlsson, Per] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
[Beattie, Mary] Univ Calif San Francisco, UCSF Canc Risk Program, San Francisco, CA 94143 USA.
[Beattie, Mary] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
[Beattie, Mary] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Pharoah, Paul D. P.] Univ Cambridge, Dept Oncol, Cambridge, England.
[Moysich, Kirsten B.] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA.
[Karlan, Beth Y.; Gross, Jenny] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA.
[John, Esther M.] Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA.
[Daly, Mary B.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
[Buys, Saundra M.] Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA.
[Southey, Melissa C.] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia.
[Hopper, John L.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
[Terry, Mary Beth; Chung, Wendy] Columbia Univ, Dept Epidemiol, New York, NY USA.
[Miron, Alexander F.] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.
[Goldgar, David] Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USA.
[GEMO Study Collaborators] Federat Natl Ctr Lutte Canc, Canc Genet Network, Grp Genet & Canc, Paris, France.
[Ontario Canc Genetics Network] Canc Care Ontario, Ontario Canc Genet Network, Toronto, ON M5G 2L7, Canada.
[SWE-BRCA] Karolinska Inst, Stockholm, Sweden.
RP Mulligan, AM (reprint author), Univ Toronto, Dept Lab Med & Pathobiol, Canc Care Ontario, 100 Coll St, Toronto, ON M5S 1A8, Canada.
RI Spurdle, Amanda/A-4978-2011; Nelen, Marcel/L-4542-2015; Ligtenberg,
Marjolijn/N-9666-2013; manoukian, siranoush/E-7132-2017; Peissel,
Bernard/E-8187-2017; montagna, marco/E-2225-2012; Arnold,
Norbert/E-3012-2010; D'Andrea, Emma/B-4374-2013; Andrulis,
Irene/E-7267-2013; Hoogerbrugge, Nicoline/O-1016-2013; Radice,
Paolo/O-3119-2013; Oosterwijk, Jan C./G-5770-2011; Toland,
Amanda/E-4202-2011; Osorio, Ana/I-4324-2014; Bernard, Loris/K-5953-2014;
Ehrencrona, Hans/M-5619-2014; GLADIEFF, Laurence/O-5129-2014
OI Evans, Gareth/0000-0002-8482-5784; Blanco, Ignacio/0000-0002-7414-7481;
Ramus, Susan/0000-0003-0005-7798; Spurdle, Amanda/0000-0003-1337-7897;
Barrowdale, Daniel/0000-0003-1661-3939; Papi, Laura/0000-0003-4552-9517;
Kauff, Noah/0000-0001-7242-6156; Nevanlinna, Heli/0000-0002-0916-2976;
Fox, Stephen/0000-0002-7648-8896; Ligtenberg,
Marjolijn/0000-0003-1290-1474; manoukian, siranoush/0000-0002-6034-7562;
Peissel, Bernard/0000-0001-9233-3571; Janavicius,
Ramunas/0000-0002-3773-8485; Nordling, Margareta/0000-0002-4047-4994;
Eeles, Rosalind/0000-0002-3698-6241; Robson, Mark/0000-0002-3109-1692;
Nathanson, Katherine/0000-0002-6740-0901; montagna,
marco/0000-0002-4929-2150; Arnold, Norbert/0000-0003-4523-8808; Osorio,
Ana/0000-0001-8124-3984; Ehrencrona, Hans/0000-0002-5589-3622; GLADIEFF,
Laurence/0000-0002-6980-9719
FU Breast Cancer Research Foundation; MacDonald Family Foundation; Komen
Foundation; NIH, NCI [P50 CA 058207]; Avon Foundation; UCSF Helen Diller
Family Comprehensive Cancer Center UK; CRUK; Russian Federation for
Basic Research [10-04-92601, 10-04-92110, 11-04-00227]; Federal Agency
for Science and Innovations [02.740.11.0780]; Commission of the European
Communities [PITN-GA-2009-238132]; Royal Society [JP090615]; US National
Cancer Institute; Westat, Inc., Rockville, MD; Starr Cancer Consortium;
Norman and Carol Stone Genetic Research Fund; Robert and Kate Niehaus
Clinical Genetics Initiative at MSKCC; NIH [CA116167, CA128978];
Research Excellence (SPORE) in Breast Cancer [CA116201]; Ministero della
Salute [RFPS 2006-5-341353, ACC2/R6.9]; Kathleen Cuningham Consortium
for Research into Familial Breast Cancer (kConFab); Icelandic
Association; Landspitali University Hospital; NEYE Foundation; Deutsches
Krebsforschungszentrum (DKFZ); Associazione Italiana per la Ricerca sul
Cancro [4017]; Italian citizens; Fondazione Italiana per la Ricerca sul
Cancro; Cancer Research UK [C12292/A11174, C1287/A10118, C1287/A11990,
C5047/A8385]; NIHR; Eileen Stein Jacoby Fund; University of Kansas
Cancer Center; Kansas Bioscience Authority Eminent Scholar Program;
Familial Cancer Registry (CI); Tissue Culture Shared Registry at
Georgetown University (NIH/NCI) [P30-CA051008]; Cancer Genetics Network
[HHSN261200744000C]; Swing Fore the Cure; German Consortium of
Hereditary Breast and Ovarian Cancer (GC-HBOC) GC-HBOC; German Cancer
Aid [109076]; Centre of Molecular Medicine Cologne (CMMC); Ligue
National Contre le Cancer; Association for International Cancer
[AICR-07-0454]; Association "Le cancer du sein, parlons-en!" Award;
European Community [223175 (HEALTH-F2-2009-223175)]; National Cancer
Institute, National Institutes of Health [RFA-CA-06-503]; Liepaja's
municipal council; [NO2-CP-11019-50]; [N02-CP-65504]; [U01CA69631];
[5U01CA113916]
FX This work was supported by Cancer Research UK grants C12292/A11174 and
C1287/A10118. The research leading to these results has received funding
from the European Community's Seventh Framework Programme under grant
agreement no 223175 (HEALTH-F2-2009-223175). ACA is a CR-UK
Senior Cancer Research Fellow, DFE is CR-UK Principal Research Fellow.
Study specific acknowledgments Breast Cancer Family Registry (BCFR) This
work was supported by the National Cancer Institute, National Institutes
of Health under RFA-CA-06-503 and through cooperative agreements with
members of the Breast Cancer Family Registry (BCFR) and Principal
Investigators, including Cancer Care Ontario (U01 CA69467), Columbia
University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631),
Huntsman Cancer Institute (U01 CA69446), Cancer Prevention Institute of
California (formerly the Northern California Cancer Center) (U01
CA69417), University of Melbourne (U01 CA69638), and Research Triangle
Institute Informatics Support Center (RFP No. N02PC45022-46). Samples
from the FCCC, HCI, and CPIC were processed and distributed by the
Coriell institute for Medical Research. The content of this manuscript
does not necessarily reflect the views or policies of the National
Cancer Institute or any of the collaborating centers in the BCFR, nor
does mention of trade names, commercial products or organizations imply
endorsement by the US Government or the BCFR. The Baltic Familial Breast
and Ovarian Cancer Consortium (BFBOCC Latvia and Lithuania) Lithuania:
This work is supported by the Research Council of Lithuania grant
LIG-19/2010 to Ramunas Janavicius. Latvia: We acknowledge Genome
Database of Latvian Population, Latvian Biomedical Research and Study
Center for providing data and DNA samples. This work is supported by
Liepaja's municipal council to Laima Tihomirova (Latvian Biomedical
Research and Study Centre). Copenhagen Breast Cancer Study (CBCS); We
thank the NEYE Foundation for financial support The Deutsches
Krebsforschungszentrum (DKFZ) study The study was supported by the
DKFZ.; The study was supported by the DKFZ.; The CONSIT TEAM is
supported by grants from Associazione Italiana per la Ricerca sul Cancro
(4017) and by funds from Italian citizens who allocated the 5 x 1,000
share of their tax payment in support of the Fondazione IRCCS Istituto
Nazionale Tumouri, according to Italian laws (INT-Institutional
strategic projects "5 x 1000") to PP and grants from Fondazione Italiana
per la Ricerca sul Cancro (Special Project "Hereditary tumours"),
Ministero della Salute (Extraordinary National Cancer Program 2006
"Alleanza contro il Cancro", and "Progetto Tumouri Femminili") and
Ministero dell'Universita' e Ricerca (RBLAO3-BETH) to PR. CONSIT TEAM
acknowledges the contribution of Gaia Roversi, Carla B. Ripamonti,
Marilena Morganti and Marco Pierotti of the of the Fondazione IRCCS
Istituto Nazionale dei Tumouri, Milan, Italy; Monica Barile of the
Istituto Europeo di Oncologia, Milan, Italy and Liliana Varesco of the
Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE)
EMBRACE Collaborating Centers are: Coordinating Centre, Cambridge: Steve
Ellis, Elena Fineberg, Radka Platte. North of Scotland Regional Genetics
Service, Aberdeen: Zosia Miedzybrodzka. Northern Ireland Regional
Genetics Service, Belfast: Patrick Morrison, Lisa Jeffers. West Midlands
Regional Clinical Genetics Service, Birmingham: Trevor Cole, Kai-ren
Ong, Jonathan Hoffman. South West Regional Genetics Service, Bristol:
Margaret James. East Anglian Regional Genetics Service, Cambridge: Joan
Paterson, Sarah Downing, Amy Taylor. Medical Genetics Services for
Wales, Cardiff: T. Rogers,. St James's Hospital, Dublin & National
Centre for Medical Genetics, Dublin: M. John Kennedy, David Barton.
South East of Scotland Regional Genetics Service, Edinburgh: Mary
Porteous, Sarah Drummond. Peninsula Clinical Genetics Service, Exeter:
Carole Brewer, Emma Kivuva, Anne Searle, Selina Goodman, Kathryn Hill.
West of Scotland Regional Genetics Service, Glasgow: Victoria Murday,
Nicola Bradshaw, Lesley Snadden, Mark Longmuir, Catherine Watt, Sarah
Gibson, Eshika Haque, Ed Tobias, Alexis Duncan. South East Thames
Regional Genetics Service, Guy's Hospital London: Chris Jacobs, Caroline
Langman, Anna Whaite. North West Thames Regional Genetics Service,
Harrow. Leicestershire Clinical Genetics Service, Leicester. Yorkshire
Regional Genetics Service, Leeds: Carol Chu, Julie Miller. Cheshire and
Merseyside Clinical Genetics Service, Liverpool: Ian Ellis. Manchester
Regional Genetics Service, Manchester: Jane Taylor. North East Thames
Regional Genetics Service, NE Thames, London: Alison Male, Cheryl
Berlin. Nottingham Centre for Medical Genetics, Nottingham: Rebecca
Collier. Northern Clinical Genetics Service, Newcastle: Fiona Douglas,
Oonagh Claber, Irene Jobson. Oxford Regional Genetics Service, Oxford:
Lisa Walker, Diane McLeod, Dorothy Halliday, Sarah Durell, Barbara
Stayner. The Institute of Cancer Research and Royal Marsden NHS
Foundation Trust: Susan Shanley, Nazneen Rahman, Richard Houlston,
Elizabeth Bancroft, Lucia D'Mello, Elizabeth Page, Audrey Ardern-Jones,
Kelly Kohut, Jennifer Wiggins, Elena Castro, Anita Mitra, Lisa
Robertson. North Trent Clinical Genetics Service, Sheffield: Oliver
Quarrell, Cathryn Bardsley. South West Thames Regional Genetics Service,
London: Shirley Hodgson, Sheila Goff, Glen Brice, Lizzie Winchester,
Charlotte Eddy, Vishakha Tripathi, Virginia Attard. Wessex Clinical
Genetics Service, Princess Anne Hospital, Southampton: Anneke Lucassen,
Gillian Crawford, Donna McBride, Sarah Smalley.; EMBRACE is supprted by
Cancer Research UK Grants C1287/A10118 and C1287/A11990. D. Gareth Evans
and Fiona Lalloo are supported by an NIHR grant to the Biomedical
Research Centre, Manchester. The Investigators at The Institute of
Cancer Research and The Royal Marsden NHS Foundation Trust are supported
by an NIHR grant to the Biomedical Research Centre at The Institute of
Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles,
Elizabeth Bancroft and Lucia D'Mello are also supported by Cancer
Research UK Grant C5047/A8385. Fox Chase Cancer Center Study (FCCC);
A.K.G. was funded by U01CA69631, 5U01CA113916, and the Eileen Stein
Jacoby Fund. The author acknowledges support from The University of
Kansas Cancer Center and the Kansas Bioscience Authority Eminent Scholar
Program. A. K. G. is the Chancellors Distinguished Chair in Biomedical
Sciences endowed Professor.; Work is supported by the Familial Cancer
Registry (CI) and the Tissue Culture Shared Registry at Georgetown
University (NIH/NCI grant P30-CA051008), the Cancer Genetics Network
(HHSN261200744000C) (CI), and Swing Fore the Cure (CI).; The German
Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) GC-HBOC is
supported by a grant of the German Cancer Aid (grant 109076), the Centre
of Molecular Medicine Cologne (CMMC).; The study was supported by the
Ligue National Contre le Cancer; Association for International Cancer
Research Grant (AICR-07-0454); and the Association "Le cancer du sein,
parlons-en!" Award. We wish to thank all the GEMO collaborating groups
for their contribution to this study. GEMO Collaborating Centers are:
Coordinating Centres, Unite Mixte de Genetique Constitutionnelle des
Cancers Frequents, Centre Hospitalier Universitaire de Lyon/Centre Leon
Berard, et Equipe "Genetique du cancer du sein, Centre de Recherche en
Cancerologie de Lyon: Laure Barjhoux, Carole Verny-Pierre, Sophie
Giraud, and Service de Genetique Oncologique, Institut Curie, Parise
Marion Gauthier-Villars, Bruno Buecher, Claude Houdayer, Muriel Belotti,
Carole Tirapo, Antoine de Pauw. Institut Gustave Roussy, Villejuif:
Brigitte Bressac-de-Paillerets, Audrey Remenieras, Veronique Byrde,
Olivier Caron, Gilbert Lenoir. Centre Jean Perrin, Clermont-Ferrand:
Yves-Jean Bignon, Nancy Uhrhammer. Centre Leon Berard, Lyon: Christine
Lasset, Valerie Bonadona. Centre Francois Baclesse, Caen. Institut Paoli
Calmettes, Marseille: Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi,
Francois Eisinger. Groupe Hospitalier Pitie-Salpetriere, Paris: Florence
Coulet, Chrystelle Colas, Florent Soubrier. CHU de Arnaud-de-Villeneuve,
Montpellier. Centre Oscar Lambret, Lille: Jean-Philippe Peyrat, Joelle
Fournier, Francoise Revillion, Philippe Vennin, Claude Adenis. Hopital
Rene Huguenin/Institut Curie, St Cloud: Etienne Rouleau, Rosette
Lidereau, Liliane Demange, Catherine Nogues. Centre Paul Strauss,
Strasbourg. Institut Bergonie, Bordeaux: Emmanuelle Barouk-Simonet,
Francoise Bonnet, Virginie Bubien. Institut Claudius Regaud, Toulouse:
Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel.
CHU de Grenoble: Dominique Leroux, Helene Dreyfus, Christine Rebischung,
Magalie Peysselon. CHU de Dijon: Fanny Coron, Laurence Faivre. CHU de
St-Etienne: Fabienne Prieur. Hetel Dieu Centre Hospitalier, Chambery:
Sandra Fert Ferrer. Centre Antoine Lacassagne, Nice: Marc Frenay. CHU de
Limoges: Laurence Venat-Bouvet. CHU de Nantes: Capucine Delnatte. CHU
Bretonneau, Tours. Creighton University, Omaha, USA: Henry T. Lynch,
Carrie L. Snyder.; The ILUH group was supported by the Icelandic
Association "Walking for Breast Cancer Research" and by the Landspitali
University Hospital Research Fund.; This study was supported by
"Ministero della Salute" ("Progetto Tumouri Femminili and grant numbers
RFPS 2006-5-341353, ACC2/R6.9") Kathleen Cuningham Consortium for
Research into Familial Breast Cancer (kConFab); The MAYO study was
supported by NIH grants CA116167, CA128978, a Specialized Program of
Research Excellence (SPORE) in Breast Cancer (CA116201), and awards from
the Komen Foundation for the Cure and the Breast Cancer Research
Foundation.; The study is supported by grant from the Breast Cancer
Research Foundation, Starr Cancer Consortium, Norman and Carol Stone
Genetic Research Fund, The Robert and Kate Niehaus Clinical Genetics
Initiative at MSKCC; The research of Drs. PL Mai and MH Greene was
supported by the Intramural Research Program of the US National Cancer
Institute, and by support services contracts NO2-CP-11019-50 and
N02-CP-65504 with Westat, Inc., Rockville, MD.; This work has been
supported by the Russian Federation for Basic Research (grants
10-04-92601, 10-04-92110, 11-04-00227), the Federal Agency for Science
and Innovations (contract 02.740.11.0780), the Commission of the
European Communities (grant PITN-GA-2009-238132) and through a Royal
Society International Joint grant (JP090615).; The study received
funding from the NIH, NCI Bay Area Breast Cancer SPORE (P50 CA 058207)
and the Avon Foundation. We acknowledge support from the UCSF Helen
Diller Family Comprehensive Cancer Center UK and Gilda Radner Familial
Ovarian Cancer Registries (UKGRFOCR) UKFOCR was supported by a project
grant from CRUK to Paul Pharoah. We thank Simon Gayther, Carole Pye,
Patricia Harrington and Eva Wozniak for their contributions towards the
UKFOCR. We'd like to acknowledge the Roswell Park Alliance Foundation
for their continued support of the Gilda Radner Ovarian Family Cancer
Registry. GRFOCR would like to acknowledge Lara Sucheston (Department of
Cancer Prevention and Control) and Kunle Odunsi (Departments Gynecologic
Oncology and Immunology). University of Pennsylvania (UPENN); Work is
supported by grants from the Breast Cancer Research Foundation (to KLN),
MacDonald Family Foundation (SMD) and Komen Foundation (SMD)
NR 51
TC 35
Z9 35
U1 2
U2 17
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-542X
J9 BREAST CANCER RES
JI Breast Cancer Res.
PY 2011
VL 13
IS 6
AR R110
DI 10.1186/bcr3052
PG 20
WC Oncology
SC Oncology
GA 904DK
UT WOS:000301173700002
PM 22053997
ER
PT J
AU Managadze, D
Rogozin, IB
Chernikova, D
Shabalina, SA
Koonin, EV
AF Managadze, David
Rogozin, Igor B.
Chernikova, Diana
Shabalina, Svetlana A.
Koonin, Eugene V.
TI Negative Correlation between Expression Level and Evolutionary Rate of
Long Intergenic Noncoding RNAs
SO GENOME BIOLOGY AND EVOLUTION
LA English
DT Article
DE long noncoding RNA; ncRNA; RNA expression; genomic alignments; introns;
RNA folding
ID POLYMERASE-II TRANSCRIPTION; COMPUTER-ASSISTED ANALYSIS; PROTEIN-CODING
GENE; SECONDARY STRUCTURE; SEQUENCE EVOLUTION; RAPID EVOLUTION;
MAMMALIAN GENES; WEB SERVER; CONSERVATION; GENOME
AB Mammalian genomes contain numerous genes for long noncoding RNAs (lncRNAs). The functions of the lncRNAs remain largely unknown but their evolution appears to be constrained by purifying selection, albeit relatively weakly. To gain insights into the mode of evolution and the functional range of the lncRNA, they can be compared with much better characterized protein-coding genes. The evolutionary rate of the protein-coding genes shows a universal negative correlation with expression: highly expressed genes are on average more conserved during evolution than the genes with lower expression levels. This correlation was conceptualized in the misfolding-driven protein evolution hypothesis according to which misfolding is the principal cost incurred by protein expression. We sought to determine whether long intergenic ncRNAs (lincRNAs) follow the same evolutionary trend and indeed detected a moderate but statistically significant negative correlation between the evolutionary rate and expression level of human and mouse lincRNA genes. The magnitude of the correlation for the lincRNAs is similar to that for equal-sized sets of protein-coding genes with similar levels of sequence conservation. Additionally, the expression level of the lincRNAs is significantly and positively correlated with the predicted extent of lincRNA molecule folding (base-pairing), however, the contributions of evolutionary rates and folding to the expression level are independent. Thus, the anticorrelation between evolutionary rate and expression level appears to be a general feature of gene evolution that might be caused by similar deleterious effects of protein and RNA misfolding and/or other factors, for example, the number of interacting partners of the gene product.
C1 [Managadze, David; Rogozin, Igor B.; Chernikova, Diana; Shabalina, Svetlana A.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Koonin, EV (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
EM koonin@ncbi.nlm.nih.gov
RI Shabalina, Svetlana/N-8939-2013
OI Shabalina, Svetlana/0000-0003-2272-7473
FU National Library of Medicine at National Institutes of Health (US
Department Health and Human Services)
FX We thank Liran Carmel, Joshua Cherry, Jean Thierri-Mieg, Mikhail
Galperin, Alexander Lobkovsky, Kira Makarova, and Yuri Wolf for useful
discussions. This work was supported by the Intramural Research Program
of the National Library of Medicine at National Institutes of Health (US
Department Health and Human Services).
NR 90
TC 38
Z9 44
U1 0
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1759-6653
J9 GENOME BIOL EVOL
JI Genome Biol. Evol.
PY 2011
VL 3
BP 1390
EP 1404
DI 10.1093/gbe/evr116
PG 15
WC Evolutionary Biology; Genetics & Heredity
SC Evolutionary Biology; Genetics & Heredity
GA 909AU
UT WOS:000301535100031
PM 22071789
ER
PT J
AU Hong, SK
Tanegashima, K
Dawid, IB
AF Hong, Sung-Kook
Tanegashima, Kosuke
Dawid, Igor B.
TI XIer2 is required for convergent extension movements during Xenopus
development
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE XIer2; Xenopus; convergent extension
ID GASTRULATION MOVEMENTS; FGF; ZEBRAFISH; BRACHYURY; PROTEIN; PATHWAY;
TARGET; PIP92
AB Immediate early response 2 (Ier2) is a downstream target of fibroblast growth factor (FGF) signaling. In zebrafish, Ier2 is involved in left-right asymmetry establishment and in convergent extension movements. We isolated the Xenopus ier2 gene based on sequence similarity searches using multiple vertebrate species. Xenopus Ier2 has high homology in the N-terminal region to other vertebrate Ier2 proteins, and Xier2 transcripts were observed from oocytes through larval stages. Except for the maternal expression of xier2, the expression of this gene in the marginal region at gastrulation and in somites and the notochord at later stages is similar to the expression pattern of zebrafish ier2. XIer2 knockdown using antisense morpholinos resulted in defects of convergent extension leading to severe neural tube defects; overexpression of Ier2 showed similar, albeit milder phenotypes. Assays in animal cap explants likewise showed inhibition of elongation after blocking XIer2 expression. These results indicate that Xenopus Ier2 is essential for the execution of convergent extension movements during early Xenopus development.
C1 [Hong, Sung-Kook; Tanegashima, Kosuke; Dawid, Igor B.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Genet Lab, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA.
[Hong, Sung-Kook] NHGRI, Mol Genet Branch, NIH, Bethesda, MD 20892 USA.
[Tanegashima, Kosuke] Tokyo Metropolitan Inst Med Sci, Tokyo 113, Japan.
RP Dawid, IB (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Genet Lab, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA.
EM idawid@nih.gov
FU National Institute for Child Health and Human Development, NIH
FX We thank Martha Rebbert for help with experiments and sequence
alignments. This work was supported by the intramural research program
of the National Institute for Child Health and Human Development, NIH.
NR 16
TC 2
Z9 2
U1 0
U2 0
PU U B C PRESS
PI BILBAO
PA UNIV BASQUE COUNTRY, EDITORIAL SERVICES, PO BOX 1397, E-48080 BILBAO,
SPAIN
SN 0214-6282
J9 INT J DEV BIOL
JI Int. J. Dev. Biol.
PY 2011
VL 55
IS 10-12
BP 917
EP 921
DI 10.1387/ijdb.113288sh
PG 5
WC Developmental Biology
SC Developmental Biology
GA 905YP
UT WOS:000301312400003
PM 22252488
ER
PT J
AU Dente, L
Gestri, G
Tsang, M
Kudoh, T
Wilson, SW
Dawid, IB
Andreazzoli, M
AF Dente, Luciana
Gestri, Gaia
Tsang, Michael
Kudoh, Tetsuhiro
Wilson, Stephen W.
Dawid, Igor B.
Andreazzoli, Massimiliano
TI Cloning and developmental expression of zebrafish pdzrn3
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE PDZRN protein; PDZ domain; RING finger; zebrafish development; ventral
retina
ID DIFFERENTIATION; EMBRYOGENESIS; MIDLINE; FINGER; DOMAIN
AB Pdzrn3, a member of the PDZRN/SEMCAP/LNX protein family containing a RING finger and two PDZ domains, has been implicated in myoblast and osteoblast differentiation. However, its spatio-temporal expression pattern during embryonic development has not been defined. Here, we describe the cloning and expression pattern of pdzrn3 during zebrafish development. We found that in addition to being expressed in several mesodermal structures, this gene displays specific expression in the central nervous system including rhombomere 1, ventral retina, thalamus and motor neurons, indicating a novel function during neural development. In particular, the absence of expression of pdzrn3 in the ventral retina of noi mutant fish suggests a possible role for this gene in regulating fasciculation and/or navigation of retinal ganglion cell axons.
C1 [Dente, Luciana; Andreazzoli, Massimiliano] Univ Pisa, Dept Biol, I-56127 Pisa, Italy.
[Gestri, Gaia; Wilson, Stephen W.] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England.
[Tsang, Michael; Kudoh, Tetsuhiro; Dawid, Igor B.] NICHD, Mol Genet Lab, NIH, Bethesda, MD USA.
RP Andreazzoli, M (reprint author), Univ Pisa, Dept Biol, SS12 Abetone Brennero,4, I-56127 Pisa, Italy.
EM mandreazzoli@biologia.unipi.it
RI Zebrafish, UCL/A-3125-2009; TSANG, Michael/E-2758-2013; Tsang,
Michael/I-9305-2014;
OI TSANG, Michael/0000-0001-6384-2422; Tsang, Michael/0000-0001-7123-0063;
Andreazzoli, Massimiliano/0000-0001-9633-204X
FU National Institute of Child Health and Human Development, NIH; MIUR;
Telethon; MRC
FX This work was supported by the Intramural Research Program of the
National Institute of Child Health and Human Development, NIH, by a
grant from MIUR to M.A. and by grants from Telethon and MRC to G.G.
NR 17
TC 6
Z9 6
U1 1
U2 3
PU U B C PRESS
PI BILBAO
PA UNIV BASQUE COUNTRY, EDITORIAL SERVICES, PO BOX 1397, E-48080 BILBAO,
SPAIN
SN 0214-6282
J9 INT J DEV BIOL
JI Int. J. Dev. Biol.
PY 2011
VL 55
IS 10-12
BP 989
EP 993
DI 10.1387/ijdb.113437ld
PG 5
WC Developmental Biology
SC Developmental Biology
GA 905YP
UT WOS:000301312400012
PM 22252497
ER
PT S
AU Bock, NA
Hashim, E
Kocharyan, A
Silva, AC
AF Bock, Nicholas A.
Hashim, Eyesha
Kocharyan, Ara
Silva, Afonso C.
BE Johnson, JI
Zeigler, HP
Hof, PR
TI Visualizing myeloarchitecture with magnetic resonance imaging in
primates
SO RESOURCES AND TECHNOLOGICAL ADVANCES FOR STUDIES OF NEUROBEHAVIORAL
EVOLUTION
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on New Studies of Neurobehavioral Evolution
CY JUN 25-28, 2010
CL Armed Forces Inst Pathol, Washington, DC
SP Neuroscience Assoc Inc, Michigan State Univ, Dept Radiol
HO Armed Forces Inst Pathol
DE magnetic resonance imaging; brain mapping; cortex; myelin; primate
ID MONKEY CALLITHRIX-JACCHUS; DORSOLATERAL FRONTAL-CORTEX; MARMOSET MONKEY;
CEREBRAL-CORTEX; VISUOTOPIC ORGANIZATION; EXTRASTRIATE CORTICES; COMMON
MARMOSET; AREAS; CONNECTIONS; DORSAL
AB The pattern of myelination over the cerebral cortex, termed myeloarchitecture, is an established and often-used feature to visualize cortical organization with histology in a variety of primate species. In this paper, we use in vivo magnetic resonance imaging (MRI) and advanced image processing using surface rendering to visualize and characterize myeloarchitecture in a small nonhuman primate, the common marmoset (Callithrix jacchus). Through images made in four female adult marmosets, we produce a representative 3D map of marmoset myeloarchitecture and flatten and annotate this map to show the location and extent of a variety of major areas of the cortex, including the primary visual, auditory, and somatosensory areas. By treating our MRI data as a surface, we can measure the surface area of cortical areas, and we present these measurements here to summarize cortical organization in the marmoset.
C1 [Bock, Nicholas A.; Hashim, Eyesha] McMaster Univ, Hamilton, ON L8S 4K1, Canada.
[Kocharyan, Ara; Silva, Afonso C.] Natl Inst Neurol Disorders & Stroke, Cerebral Microcirculat Unit, Lab Funct & Mol Imaging, NIH, Bethesda, MD USA.
RP Bock, NA (reprint author), McMaster Univ, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.
EM bockn@mcmaster.ca
FU Intramural NIH HHS [ZIA NS003041-04]
NR 45
TC 19
Z9 19
U1 2
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1225
IS S1
BP E171
EP E181
DI 10.1111/j.1749-6632.2011.06000.x
PG 11
WC Multidisciplinary Sciences; Neurosciences
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BZD69
UT WOS:000301187000011
PM 21599695
ER
PT S
AU Chowdhury, AS
Burns, J
Sen, B
Mukherjee, A
Yao, JH
Summers, RM
AF Chowdhury, Ananda S.
Burns, Joseph
Sen, Bhaskar
Mukherjee, Arka
Yao, Jianhua
Summers, Ronald M.
GP IEEE
TI DETECTION OF PELVIC FRACTURES USING GRAPH CUTS AND CURVATURES
SO 2011 18TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP)
SE IEEE International Conference on Image Processing ICIP
LA English
DT Proceedings Paper
CT 18th IEEE International Conference on Image Processing (ICIP)
CY SEP 11-14, 2011
CL Brussels, BELGIUM
SP IEEE, IEEE Signal Proc Soc (SPS)
DE Pelvic fracture; Graph Cut; Mean and Gaussian curvatures
ID EPIDEMIOLOGY; SEGMENTATION
AB Traumatic injury of the pelvis is common and potentially devastating, with pelvic fractures being a major cause of trauma patient mortality. Detection and management of pelvic injuries is challenging due to varying injury patterns and resulting complications such as hemorrhage and infection. In this paper, we investigate the application of computer-aided detection (CAD) techniques for pelvic fracture detection. We propose a fast semi-automated method of pelvic fracture detection using a combination of i) graph cuts and ii) mean and Gaussian curvatures. A fracture is modeled as a minimum cut in a weighted graph. The same fracture is alternatively modeled as a valley based on the signs of mean and Gaussian curvatures. Each of these methods, in isolation, generates false positives in addition to the true fracture. We then combine the two methods and perform a neighborhood analysis to eliminate the false positives. Experimental results indicate that proposed method is very promising.
C1 [Chowdhury, Ananda S.; Sen, Bhaskar; Mukherjee, Arka] Jadavpur Univ, Dept Elect & Telecom Engn, Kolkata 700032, India.
[Burns, Joseph; Yao, Jianhua; Summers, Ronald M.] NIH, Clin Ctr, Dept Radiol & Imag Sci, Bethesda, MD 20892 USA.
[Burns, Joseph] Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USA.
RP Chowdhury, AS (reprint author), Jadavpur Univ, Dept Elect & Telecom Engn, Kolkata 700032, India.
EM ananda.chowdhury@gmail.com; jburns@uci.edu; bhaskarsen.ju@gmail.com;
arkamukherjee49@gmail.com; jyao@cc.nih.gov; rms@nih.gov
FU Imaging Sciences Training Program; Radiology and Imaging Sciences
Department; National Institute of Biomedical Imaging and Bioengineering
of the National Institutes of Health; National Institutes of Health
Clinical Center
FX This research was supported in part by the Imaging Sciences Training
Program sponsored by the Radiology and Imaging Sciences Department and
the National Institute of Biomedical Imaging and Bioengineering of the
National Institutes of Health. This research was also supported in part
by the National Institutes of Health Clinical Center.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1522-4880
BN 978-1-4577-1303-3
J9 IEEE IMAGE PROC
PY 2011
BP 1573
EP 1576
PG 4
WC Engineering, Electrical & Electronic; Imaging Science & Photographic
Technology
SC Engineering; Imaging Science & Photographic Technology
GA BYI89
UT WOS:000298962501175
ER
PT S
AU Bagci, U
Yao, JH
Caban, J
Palmore, TN
Suffredini, AF
Mollura, DJ
AF Bagci, Ulas
Yao, Jianhua
Caban, Jesus
Palmore, Tara N.
Suffredini, Anthony F.
Mollura, Daniel J.
GP IEEE
TI Automatic Detection of Tree-in-Bud Patterns for Computer Assisted
Diagnosis of Respiratory Tract Infections
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID IMAGE SEGMENTATION
AB Abnormal nodular branching opacities at the lung periphery in Chest Computed Tomography (CT) are termed by radiology literature as tree-in-bud (TIB) opacities. These subtle opacity differences represent pulmonary disease in the small airways such as infectious or inflammatory bronchiolitis. Precisely quantifying the detection and measurement of TIB abnormality using computer assisted detection (CAD) would assist clinical and research investigation of this pathology commonly seen in pulmonary infections. This paper presents a novel method for automatically detecting TIB patterns based on fast localization of candidates using local scale information of the images. The proposed method combines shape index, local gradient statistics, and steerable wavelet features to automatically identify TIB patterns. Experimental results using 39 viral bronchiolitis human para-influenza (HPIV) CTs and 21 normal lung CTs achieved an overall accuracy of 89.95%.
C1 [Bagci, Ulas; Mollura, Daniel J.] NIH, Ctr Infect Dis Imaging, Bldg 10, Bethesda, MD 20892 USA.
[Bagci, Ulas; Yao, Jianhua; Mollura, Daniel J.] NIH, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA.
[Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
[Palmore, Tara N.] NIH, Lab Clin Infectious Diseases, Bethesda, MD 20892 USA.
[Suffredini, Anthony F.] NIH, Critical Care Med Dept, Bethesda, MD 20892 USA.
RP Bagci, U (reprint author), NIH, Ctr Infect Dis Imaging, Bldg 10, Bethesda, MD 20892 USA.
EM ulas.bagci@nih.gov
OI Bagci, Ulas/0000-0001-7379-6829
FU Imaging Sciences Training Program (ISTP); Radiology and Imaging Sciences
Department of NIH Clinical Center; National Institutes of Allergy and
Infectious Diseases; National Institutes of Bio-imaging and
Bioengineerin
FX This research is supported in part by the Imaging Sciences Training
Program (ISTP), the Center for Infectious Disease Imaging Intramural
program in the Radiology and Imaging Sciences Department of the NIH
Clinical Center, the Intramural Program of the National Institutes of
Allergy and Infectious Diseases, and the Intramural Research Program of
the National Institutes of Bio-imaging and Bioengineerin.
NR 10
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 5096
EP 5099
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810004010
ER
PT S
AU Karargyris, A
Antani, S
Thoma, G
AF Karargyris, Alexandros
Antani, Sameer
Thoma, George
GP IEEE
TI Segmenting Anatomy in Chest X-rays for Tuberculosis Screening
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID RADIOGRAPHS; DIFFERENTIATION; IMAGES; CELLS
AB In this paper we describe the development of a screening system for pulmonary pathologies (i.e. pneumonia, tuberculosis) application in global healthcare settings. As a first step toward this goal, the paper presents a novel approach for detecting lungs and ribs in chest radiographs. The approach is a unified method combining two detection schemes resulting in reduced cost. The novelty of our approach lies on the fact that instead of using pixel-wise techniques exclusively we used region-based features computed as wavelet features that take into consideration the orientation of anatomic structures. Initial results are described. Next steps include classification of non-rib lung regions for radiographic patterns suggesting tuberculosis infection.
C1 [Karargyris, Alexandros; Antani, Sameer; Thoma, George] NIH, US Natl Lib Med, Bethesda, MD 20892 USA.
RP Karargyris, A (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
OI Antani, Sameer/0000-0002-0040-1387
NR 22
TC 8
Z9 8
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 7779
EP 7782
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810005320
ER
PT S
AU Makrogiannis, S
Ramachandran, R
Fishbein, KW
Kapogiannis, D
Spencer, RG
Chia, CW
AF Makrogiannis, Sokratis
Ramachandran, Ramona
Fishbein, Kenneth W.
Kapogiannis, Dimitrios
Spencer, Richard G.
Chia, Chee W.
GP IEEE
TI Towards Segmentation of the Thymus in Fat and Water Parametric MR Images
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID REGENERATION
AB The thymus, an organ responsible for the development, selection, and maintenance of the peripheral T-cell population, is an important regulator of the immune system. Despite its physiological significance, it has received little attention in the medical image analysis literature. In practice, the anatomical location and variable shape of this gland pose challenges both in the image acquisition and analysis processes. We present an automated method for segmenting the thymus from water and fat parametric MR images that permits further analysis of volumetrics and tissue characterization. We compute fat ratio and water ratio parametric images and introduce the use of a stochastic edge detector that is embedded in a geometric variational segmentation model. Validation experiments of the proposed algorithm against manual delineations of the thymus indicate the applicability of our approach.
C1 [Makrogiannis, Sokratis; Ramachandran, Ramona; Fishbein, Kenneth W.; Kapogiannis, Dimitrios; Spencer, Richard G.; Chia, Chee W.] NIA, NIH, Baltimore, MD 21225 USA.
RP Makrogiannis, S (reprint author), NIA, NIH, 3001 S Hanover St, Baltimore, MD 21225 USA.
EM makrogianniss@mail.nih.gov
OI Fishbein, Kenneth/0000-0002-6353-4603
NR 15
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 8078
EP 8081
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810006050
ER
PT S
AU Venkatakrishnan, A
Contreras-Vidal, JL
Sandrini, M
Cohen, LG
AF Venkatakrishnan, Anusha
Contreras-Vidal, Jose L.
Sandrini, Marco
Cohen, Leonardo G.
GP IEEE
TI Independent component analysis of resting brain activity reveals
transient modulation of local cortical processing by transcranial direct
current stimulation
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID DC STIMULATION
AB Neuroplasticity induced by transcranial direct current stimulation (tDCS) contributes to motor learning although the underlying mechanisms are incompletely understood. Here, we investigated the effects of tDCS on resting brain dynamics recorded by whole-head magnetoencephalography (MEG) pre- and up to 35 minutes post-tDCS or sham over the left primary motor cortex (M1) in healthy adults. Owing to superior temporal and spatial resolution of MEG, we sought to apply a robust, blind and data-driven analytic approach such as independent component analysis (ICA) and statistical clustering to these data to investigate potential neuroplastic effects of tDCS during resting state conditions. We found decreased alpha and increased gamma band power that outlasted the real tDCS stimulation period in a fronto-parietal motor network relative to sham. However, this method could not find differences between anodal and cathodal polarities of tDCS. These results suggest that tDCS over M1 modulates resting brain dynamics in a fronto-parietal motor network (that includes the stimulated location), indicative of within-network enhanced localized cortical processing.
C1 [Venkatakrishnan, Anusha] Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
[Venkatakrishnan, Anusha] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA.
[Venkatakrishnan, Anusha] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat, Bethesda, MD 20814 USA.
[Contreras-Vidal, Jose L.] Univ Maryland, Dept Kinesiol, Grad Programs Bioengn & Neurosci & Cognit Sci, College Pk, MD 20742 USA.
[Sandrini, Marco] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA.
[Sandrini, Marco] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA.
[Cohen, Leonardo G.] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA.
RP Venkatakrishnan, A (reprint author), Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
EM venkatakrishna@ninds.nih.gov; pepeum@umd.edu; sandrinim@ninds.nih.gov;
cohenl@ninds.nih.gov
RI Sandrini, Marco/J-2276-2014
OI Sandrini, Marco/0000-0002-1664-5722
FU Department of Defense in the Center for Neuroscience and Regenerative
Medicine, Uniformed Services University of Health Sciences, Bethesda, MD
USA; Intramural Research Program of National Institute of Neurological
Disorders and Stroke (NINDS), Bethesda, MD USA
FX This work was supported by the Department of Defense in the Center for
Neuroscience and Regenerative Medicine, Uniformed Services University of
Health Sciences, Bethesda, MD USA and the Intramural Research Program of
National Institute of Neurological Disorders and Stroke (NINDS),
Bethesda, MD USA.
NR 13
TC 6
Z9 6
U1 6
U2 8
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 8102
EP 8105
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810006056
ER
PT S
AU Park, HS
Yoon, JW
Kim, J
Iseki, K
Hallett, M
AF Park, Hyung-Soon
Yoon, Jung Won
Kim, Jonghyun
Iseki, Kazumi
Hallett, Mark
GP IEEE
TI Development of a VR-based Treadmill Control Interface for Gait
Assessment of Patients with Parkinson's Disease
SO 2011 IEEE INTERNATIONAL CONFERENCE ON REHABILITATION ROBOTICS (ICORR)
SE International Conference on Rehabilitation Robotics ICORR
LA English
DT Proceedings Paper
CT IEEE International Conference on Rehabilitation Robotics
(ICORR)/International Neurorehabilitation Symposium (INRS)/International
Conference on Virtual Rehabilitation (ICVR)
CY JUN 27-JUL 01, 2011
CL ETH Zurich, Zurich, SWITZERLAND
SP IEEE, RA, EMB, Hocoma, You Rehab, Int Soc Virtual Rehabil (ISVR), Zentrum Ambulante Rehabil, MUNDUS, RITZ
HO ETH Zurich
DE BWSTI (body-weight supported treadmill interface); treadmill control;
virtual reality; gait assessment; freeze of gait; Parkinson's Disease
ID WALKING; SPEED
AB Freezing of gait (FOG) is a commonly observed phenomenon in Parkinson's disease, but its causes and mechanisms are not fully understood. This paper presents the development of a virtual reality (VR)-based body-weight supported treadmill interface (BWSTI) designed and applied to investigate FOG. The BWSTI provides a safe and controlled walking platform which allows investigators to assess gait impairments under various conditions that simulate real life. In order to be able to evoke FOG, our BWSTI employed a novel speed adaptation controller, which allows patients to drive the treadmill speed. Our interface responsively follows the subject's intention of changing walking speed by the combined use of feedback and feedforward controllers. To provide realistic visual stimuli, a three dimensional VR system is interfaced with the speed adaptation controller and synchronously displays realistic visual cues. The VR-based BWSTI was tested with three patients with PD who are known to have FOG. Visual stimuli that might cause FOG were shown to them while the speed adaptation controller adjusted treadmill speed to follow the subjects' intention. Two of the three subjects showed FOG during the treadmill walking.
C1 [Park, Hyung-Soon; Yoon, Jung Won; Kim, Jonghyun] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
[Iseki, Kazumi; Hallett, Mark] NIH, Natl Inst Neurol Disorders & Stroke, Bethesda, MD 20892 USA.
[Yoon, Jung Won] Gyeongsang Natl Univ, ReCAPT, Jinju, South Korea.
[Yoon, Jung Won] Gyeongsang Natl Univ, Sch Mech & Aerosp Engn, Jinju, South Korea.
RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
EM parkhs@cc.nih.gov
FU Intramural Research Program of NINDS; Clinical Center in NIH
[10-N-0009]; CNRM (Center for Neuroscience and Regenerative Medicine)
program [G1707C]
FX This research is supported by the Intramural Research Program of NINDS
and Clinical Center in NIH (protocol number 10-N-0009) and CNRM (Center
for Neuroscience and Regenerative Medicine) program (grant number
G1707C).
NR 15
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7898
BN 978-1-4244-9862-8
J9 INT C REHAB ROBOT
PY 2011
PG 5
WC Robotics; Rehabilitation
SC Robotics; Rehabilitation
GA BYK51
UT WOS:000299169800125
ER
PT S
AU Kupfer, DJ
Angst, J
Berk, M
Dickerson, F
Frangou, S
Frank, E
Goldstein, BI
Harvey, A
Laghrissi-Thode, F
Leboyer, M
Ostacher, MJ
Sibille, E
Strakowski, SM
Suppes, T
Tohen, M
Yolken, RH
Young, LT
Zarate, CA
AF Kupfer, David J.
Angst, Jules
Berk, Michael
Dickerson, Faith
Frangou, Sophia
Frank, Ellen
Goldstein, Benjamin I.
Harvey, Allison
Laghrissi-Thode, Fouzia
Leboyer, Marion
Ostacher, Michael J.
Sibille, Etienne
Strakowski, Stephen M.
Suppes, Trisha
Tohen, Mauricio
Yolken, Robert H.
Young, L. Trevor
Zarate, Carlos A.
GP Annals NY Acad Sci
TI Advances in bipolar disorder: selected sessions from the 2011
International Conference on Bipolar Disorder
SO ANNALS MEETING REPORTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Bipolar Disorder (ICBD)
CY JUN 09-11, 2011
CL Pittsburgh, PA
DE bipolar disorders; medical comorbidity; neuroscience; diagnosis
ID MAJOR DEPRESSIVE DISORDER; CONSENSUS COGNITIVE BATTERY;
ELECTRON-TRANSPORT CHAIN; C-REACTIVE PROTEIN; PREFRONTAL CORTEX; I
DISORDER; SUBTHRESHOLD BIPOLARITY; FACIAL EXPRESSIONS; FUNCTIONAL
NEUROANATOMY; PSYCHIATRIC-DISORDERS
AB Recently, the 9th International Conference on Bipolar Disorder (ICBD) took place in Pittsburgh, PA, June 9-11, 2011. The conference focused on a number of important issues concerning the diagnosis of bipolar disorders across the life span, advances in neuroscience, treatment strategies for bipolar disorders, early intervention, and medical comorbidity. Several of these topics were discussed in four plenary sessions. This meeting report describes the major points of each of these sessions and included (1) strategies for moving biology forward; (2) bipolar disorder and the forthcoming new DSM-5 nomenclature; (3) management of bipolar disorders-both theory and intervention, with an emphasis on the medical comorbidities; and, (4) a review of several key task force reports commissioned by the International Society for Bipolar Disorder (ISBD).
C1 [Kupfer, David J.] Univ Pittsburgh, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
[Angst, Jules] Univ Zurich, Hosp Psychiat, Zurich, Switzerland.
[Berk, Michael] Univ Melbourne, Melbourne, Vic, Australia.
[Dickerson, Faith] Sheppard Pratt Hlth Syst, Baltimore, MD USA.
[Frangou, Sophia] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
[Goldstein, Benjamin I.; Young, L. Trevor] Univ Toronto, Fac Med, Toronto, ON, Canada.
[Harvey, Allison] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Laghrissi-Thode, Fouzia] F Hoffmann La Roche Ltd, Basel, Switzerland.
[Leboyer, Marion] Univ Paris 12, Hop Chenevier Mondor, Creteil, France.
[Ostacher, Michael J.; Suppes, Trisha] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA.
[Strakowski, Stephen M.] Univ Cincinnati, Acad Hlth Ctr, Cincinnati, OH USA.
[Tohen, Mauricio] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Zarate, Carlos A.] NIMH, Bethesda, MD 20892 USA.
RP Kupfer, DJ (reprint author), Univ Pittsburgh, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM kupferdj@upmc.edu
RI Frangou, Sophia/A-2672-2013; Berk, Michael/M-7891-2013;
OI Berk, Michael/0000-0002-5554-6946; Ostacher, Michael/0000-0003-0353-7535
FU AstraZeneca LP; Merck Sharp & Dohme Corporation; Bristol-Myers Squibb;
Cyberonics, Inc.; Community Care Behavioral Health Organization (an
affiliate of the UPMC Health Plan); Fine Foundation; Staunton Farm
Foundation
FX The Ninth International Conference on Bipolar Disorders was supported in
part by educational grants from AstraZeneca LP, Merck Sharp & Dohme
Corporation, Bristol-Myers Squibb, and Cyberonics, Inc. Funding for this
conference was also made possible by contributions from the Community
Care Behavioral Health Organization (an affiliate of the UPMC Health
Plan), the Fine Foundation, and the Staunton Farm Foundation.
NR 120
TC 11
Z9 11
U1 4
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-855-6
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1242
BP 1
EP 25
DI 10.1111/j.1749-6632.2011.06336.x
PG 25
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA BZE83
UT WOS:000301290100001
PM 22191553
ER
PT J
AU Ke, HN
Zhang, JY
Akiyama, SK
French, JE
AF Ke, Hengning
Zhang, Jennifer Y.
Akiyama, Steven K.
French, John E.
TI BCL2 interaction with actin in vitro may inhibit cell motility by
enhancing actin polymerization
SO CELL ADHESION & MIGRATION
LA English
DT Article
DE BCL2; actin polymerization; cell motility; adhesion
ID MAMMARY EPITHELIAL-CELLS; TRANSGENIC MICE; ADHESION; EXPRESSION;
OVEREXPRESSION; APOPTOSIS; PROMOTES; SURVIVAL; DIFFERENTIATION;
LAMELLIPODIA
AB In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when overexpressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that functions to decrease gelsolin-severing activity to increase actin polymerization and, thus, suppress cell adhesive processes. The linkage between increased BCL2 and increased actin polymerization on the one hand and suppression of cell adhesion, spreading and motility on the other hand, is a novel observation that may provide a plausible explanation for why BCL2 overexpression in some tumors is correlated with improved patient survival. In addition, we have identified conditions in vitro in which F-actin polymerization can be increased while cell motility is reduced. These findings underscore the possibility that BCL2 may be involved in modulating cytoskeleton reorganization and may provide an opportunity to explore signal transduction pathways important for cell adhesion and migration and to develop small molecule therapies for suppression of cancer metastasis.
C1 [French, John E.] Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA.
[Akiyama, Steven K.] Natl Inst Environm Hlth Sci, Lab Mol Carcinogenesis, NIH, Res Triangle Pk, NC USA.
[Ke, Hengning; Zhang, Jennifer Y.] Duke Univ, Med Ctr, Dept Dermatol, Durham, NC USA.
RP French, JE (reprint author), Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA.
EM french@niehs.nih.gov
OI Zhang, Jennifer/0000-0002-4485-1750
FU Division of Intramural Research, NIEHS, NIH; NIAMSD, NIH [K01AR051470]
FX This manuscript was supported by the Division of Intramural Research,
NIEHS, NIH and by NIAMSD, NIH grant K01AR051470 awarded to Dr. Jennifer
Y. Zhang. Thanks to Dr. Douglas S. Tyler, Duke University, Durham, NC
for providing A2058 melanoma cell lines and to Dr. Christine Sorenson,
University of Wisconsin, Madison, WI, for the generous gift of the mouse
Bcl2 deficient cells. We thank Ms. Vineela Gandham for her editing of
this manuscript.
NR 34
TC 3
Z9 3
U1 0
U2 4
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1933-6918
J9 CELL ADHES MIGR
JI Celll Adhes. Migr.
PD JAN-FEB
PY 2011
VL 5
IS 1
BP 6
EP 10
DI 10.4161/cam.5.1.13175
PG 5
WC Cell Biology
SC Cell Biology
GA 898CG
UT WOS:000300712400003
PM 20716950
ER
PT J
AU Melgar, MF
Collins, FS
Sethupathy, P
AF Melgar, Michael F.
Collins, Francis S.
Sethupathy, Praveen
TI Discovery of active enhancers through bidirectional expression of short
transcripts
SO GENOME BIOLOGY
LA English
DT Article
DE Transcription; pausing; naive bayes classifier; gene regulation; histone
modification; enhancers; chromatin marks; CTCF
ID RNA-POLYMERASE-II; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; GENOME-WIDE;
DROSOPHILA-MELANOGASTER; CHROMATIN STATE; GLOBAL ANALYSIS; HUMAN
PROMOTERS; ORGANIZATION; RESOLUTION
AB Background
Long-range regulatory elements, such as enhancers, exert substantial control over tissue-specific gene expression patterns. Genome-wide discovery of functional enhancers in different cell types is important for our understanding of genome function as well as human disease etiology.
Results
In this study, we developed an in silico approach to model the previously reported phenomenon of transcriptional pausing, accompanied by divergent transcription, at active promoters. We then used this model for large-scale prediction of non-promoter associated bidirectional expression of short transcripts. Our predictions were significantly enriched for DNase hypersensitive sites, histone H3 lysine 27 acetylation (H3K27ac), and other chromatin marks associated with active rather than poised or repressed enhancers. We also detected modest bidirectional expression at binding sites of the CCCTC-factor (CTCF) genome-wide, particularly those that overlap H3K27ac.
Conclusions
Our findings indicate that the signature of bidirectional expression of short transcripts, learned from promoter-proximal transcriptional pausing, can be used to predict active long-range regulatory elements genome-wide, likely due in part to specific association of RNA polymerase with enhancer regions.
C1 [Melgar, Michael F.; Collins, Francis S.] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA.
[Sethupathy, Praveen] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
[Sethupathy, Praveen] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA.
[Sethupathy, Praveen] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
RP Collins, FS (reprint author), NHGRI, Genome Technol Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM melgamoose@gmail.com; Francis.Collins@nih.gov;
praveen_sethupathy@med.unc.edu
FU NIH Division of Intramural Research/NHGRI [Z01-HG000024]; NIDDK/NIH
[1K99DK091318-01]
FX The authors thank Rachel L. Goldfeder and Peter S. Chines for generating
mouse genome (mm9) mapability data, as well as Michael L. Stitzel,
Michael R. Erdos, and other members of the Collins laboratory for
helpful discussions, insights, and suggestions for the manuscript. This
study was supported by the NIH Division of Intramural Research/NHGRI
project number Z01-HG000024 (F.S.C.), and by an NIDDK/NIH K99 grant
1K99DK091318-01 (P.S.).
NR 48
TC 35
Z9 36
U1 1
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-6906
EI 1474-760X
J9 GENOME BIOL
JI Genome Biol.
PY 2011
VL 12
IS 11
AR R113
DI 10.1186/gb-2011-12-11-r113
PG 35
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 904FB
UT WOS:000301178400004
PM 22082242
ER
PT S
AU Shao, SC
Hegde, RS
AF Shao, Sichen
Hegde, Ramanujan S.
BE Schekman, R
Goldstein, L
Lehmann, R
TI Membrane Protein Insertion at the Endoplasmic Reticulum
SO ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27
SE Annual Review of Cell and Developmental Biology
LA English
DT Review; Book Chapter
DE targeting; protein translocation
ID SIGNAL RECOGNITION PARTICLE; TAIL-ANCHORED PROTEINS; TRANSMEMBRANE
ALPHA-HELICES; POSITIVELY CHARGED RESIDUES; GENOME-WIDE ANALYSIS;
N-TERMINAL DOMAIN; ER MEMBRANE; SACCHAROMYCES-CEREVISIAE;
ESCHERICHIA-COLI; TRANSLOCATION CHANNEL
AB Integral membrane proteins of the cell surface and most intracellular compartments of eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and parallel pathways mediate membrane protein targeting to and insertion into this organelle. The classical cotranslational pathway, utilized by most membrane proteins, involves targeting by the signal recognition particle followed by insertion via the Sec61 translocon. A more specialized posttranslational pathway, employed by many tail-anchored membrane proteins, is composed of entirely different factors centered around a cytosolic ATPase termed TRC40 or Get3. Both of these pathways overcome the same biophysical challenges of ferrying hydrophobic cargo through an aqueous milieu, selectively delivering it to one among several intracellular membranes and asymmetrically integrating its transmembrane domain(s) into the lipid bilayer. Here, we review the conceptual and mechanistic themes underlying these core membrane protein insertion pathways, the complexities that challenge our understanding, and future directions to overcome these obstacles.
C1 [Shao, Sichen; Hegde, Ramanujan S.] NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
[Shao, Sichen] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA.
RP Shao, SC (reprint author), NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
EM hegde.science@gmail.com
OI Shao, Sichen/0000-0003-2679-5537; Hegde, Ramanujan/0000-0001-8338-852X
FU Intramural NIH HHS [ZIA HD008752-08]
NR 181
TC 89
Z9 92
U1 5
U2 34
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1081-0706
BN 978-0-8243-3127-6
J9 ANNU REV CELL DEV BI
JI Annu. Rev. Cell Dev.Biol.
PY 2011
VL 27
BP 25
EP 56
DI 10.1146/annurev-cellbio-092910-154125
PG 32
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA BYL23
UT WOS:000299230700002
PM 21801011
ER
PT S
AU Szabo, R
Bugge, TH
AF Szabo, Roman
Bugge, Thomas H.
BE Schekman, R
Goldstein, L
Lehmann, R
TI Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental
Biology
SO ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27
SE Annual Review of Cell and Developmental Biology
LA English
DT Review; Book Chapter
DE homeostasis; morphogenesis; pericellular proteolysis
ID EPITHELIAL SODIUM-CHANNEL; PROATRIAL NATRIURETIC PEPTIDE; EPIDERMAL
BARRIER FUNCTION; IRON-DEFICIENCY ANEMIA; AUTOSOMAL RECESSIVE
ICHTHYOSIS; FACTOR ACTIVATOR INHIBITOR-1; GENOME-WIDE ASSOCIATION; LUNG
LIQUID CLEARANCE; NEURAL-TUBE DEFECTS; NETHERTON-SYNDROME
AB Analysis of vertebrate genome sequences at the turn of the millennium revealed that a vastly larger repertoire of enzymes execute proteolytic cleavage reactions within the pericellular and extracellular environments than was anticipated from biochemical and molecular analysis. Most unexpected was the unveiling of an entire new family of structurally unique multidomain serine proteases that are anchored directly to the plasma membrane. Unlike secreted serine proteases, which function primarily in tissue repair, immunity, and nutrient uptake, these membrane-anchored serine proteases regulate fundamental cellular and developmental processes, including tissue morphogenesis, epithelial barrier function, ion and water transport, cellular iron export, and fertilization. Here the cellular and developmental biology of this fascinating new group of proteases is reviewed. Particularly highlighted is how the study of membrane-anchored serine proteases has expanded our knowledge of the range of physiological processes that require regulated proteolysis at the cell surface.
C1 [Szabo, Roman; Bugge, Thomas H.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
RP Szabo, R (reprint author), Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
EM rszabo@nidcr.nih.gov; thomas.bugge@nih.gov
FU Intramural NIH HHS [ZIA DE000699-12]
NR 150
TC 38
Z9 38
U1 2
U2 8
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1081-0706
BN 978-0-8243-3127-6
J9 ANNU REV CELL DEV BI
JI Annu. Rev. Cell Dev.Biol.
PY 2011
VL 27
BP 213
EP 235
DI 10.1146/annurev-cellbio-092910-154247
PG 23
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA BYL23
UT WOS:000299230700009
PM 21721945
ER
PT J
AU Song, GF
Ling, C
AF Song, Guangfeng
Ling, Chen
TI Users' Attitude and Strategies in Information Management With Multiple
Computers
SO INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
LA English
DT Article
ID MEMORY; SYSTEMS; DESIGN; INTERFACES; DOCUMENTS; LOCATION; FIND
AB This article reports the result of a survey study on how users utilize multiple computers in personal information management tasks. Two hundred ninety-five experienced computer users answered questions regarding the selective use of computers in three usage scenarios in managing multiple types of information: files, bookmarks, and e-mails. Results showed that users pursue simple computing environment by simplifying multiple computer configurations, avoiding distribution of information among multiple computers, and avoiding conceptual distinction of multiple computers. Selective use of a computer was based on the characteristics of the computers and the tasks to be performed. Information retrieval was still primarily done manually due to problems of memory decay and information overload. It was concluded that user attitudes and strategies in using multiple computers were characterized by reactive coping and avoidance of challenges. This article provides evidence of users' problems with multiple computers and highlights the need to support the seamless usage of multiple computers.
C1 [Song, Guangfeng] NCBI, NIH, Bethesda, MD 20894 USA.
[Ling, Chen] Univ Oklahoma, Sch Ind Engn, Norman, OK 73019 USA.
RP Song, GF (reprint author), NCBI, NIH, 45 Ctr Dr, Bethesda, MD 20894 USA.
EM gfsong@gmail.com
NR 38
TC 1
Z9 1
U1 0
U2 8
PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS
PI PHILADELPHIA
PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA
SN 1044-7318
J9 INT J HUM-COMPUT INT
JI Int. J. Hum.-Comput. Interact.
PY 2011
VL 27
IS 8
BP 762
EP 792
DI 10.1080/10447318.2011.555307
PG 31
WC Computer Science, Cybernetics; Ergonomics
SC Computer Science; Engineering
GA 885IE
UT WOS:000299771600001
ER
PT J
AU Ong, TP
Moreno, FS
Ross, SA
AF Ong, Thomas Prates
Moreno, Fernando Salvador
Ross, Sharon Ann
TI Targeting the Epigenome with Bioactive Food Components for Cancer
Prevention
SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
LA English
DT Review
DE Bioactive food components; Cancer; DNA methylation; Epigenome; Histone
modifications; Prevention
ID INHIBITS HISTONE DEACETYLASE; CELL-CYCLE ARREST; FOLIC-ACID
SUPPLEMENTATION; GLOBAL DNA HYPOMETHYLATION; POLYCOMB GROUP PROTEINS;
TUMOR-SUPPRESSOR GENES; EMBRYONIC STEM-CELLS; BREAST-CANCER; DIALLYL
DISULFIDE; IN-VIVO
AB Epigenetic processes participate in cancer development and likely influence cancer prevention. Global DNA hypomethylation, gene promoter hypermethylation and aberrant histone post-translational modifications are hallmarks of neoplastic cells which have been associated with genomic instability and altered gene expression. Because epigenetic deregulation occurs early in carcinogenesis and is potentially reversible, intervention strategies targeting the epigenome have been proposed for cancer prevention. Bioactive food components (BFCs) with anticancer potential, including folate, polyphenols, selenium, retinoids, fatty acids, isothiocyanates and allyl compounds, influence DNA methylation and histone modification processes. Such activities have been shown to affect the expression of genes involved in cell proliferation, death and differentiation that are frequently altered in cancer. Although the epigenome represents a promising target for cancer prevention with BFCs, few studies have addressed the influence of dietary components on these mechanisms in vivo, particularly on the phenotype of humans, and thus the exact mechanisms whereby diet mediates an effect on cancer prevention remains unclear. Primary factors that should be elucidated include the effective doses and dose timing of BFCs to attain epigenetic effects. Because diet-epigenome interactions are likely to occur in utero, the impact of early-life nutrition on cancer risk programming should be further investigated. Copyright (C) 2012 S. Karger AG, Basel
C1 [Ong, Thomas Prates; Moreno, Fernando Salvador] Univ Sao Paulo, Dept Alimentos & Nutr Expt, Fac Ciencias Farmaceut, Lab Diet Nutr & Canc, BR-05508900 Sao Paulo, Brazil.
[Ross, Sharon Ann] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
RP Ong, TP (reprint author), Univ Sao Paulo, Dept Alimentos & Nutr Expt, Fac Ciencias Farmaceut, Lab Diet Nutr & Canc, Bloco 14,Av Prof Lineu Prestes 580, BR-05508900 Sao Paulo, Brazil.
EM tong@usp.br
RI Ong, Thomas/C-4494-2012; Moreno, Fernando/I-1943-2013
FU FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo); CAPES
(Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior); CNPq
(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
FX Research in the Diet, Nutrition and Cancer Laboratory is supported by
FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo), CAPES
(Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) and CNPq
(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico).
NR 136
TC 29
Z9 29
U1 2
U2 15
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-6499
EI 1661-6758
J9 J NUTRIGENET NUTRIGE
JI J. Nutrigenet. Nutrigenomics
PY 2011
VL 4
IS 5
BP 275
EP 292
DI 10.1159/000334585
PG 18
WC Genetics & Heredity; Nutrition & Dietetics
SC Genetics & Heredity; Nutrition & Dietetics
GA 899FX
UT WOS:000300802900004
PM 22353664
ER
PT S
AU Gainer, H
Ponzio, TA
Yue, CM
Kawasaki, M
AF Gainer, Harold
Ponzio, Todd A.
Yue, Chunmei
Kawasaki, Makoto
BE Merighi, A
TI Intron-Specific Neuropeptide Probes
SO NEUROPEPTIDES: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Pre-mRNA; Heteronuclear RNA; hn RNA; Real-time qPCR; Oxytocin;
Vasopressin; Gene expression
ID REAL-TIME PCR; VASOPRESSIN GENE-EXPRESSION; RAT SUPRAOPTIC NUCLEUS;
CORTICOTROPIN-RELEASING HORMONE; HETERONUCLEAR RNA; MESSENGER-RNA;
IN-VIVO; INSITU HYBRIDIZATION; ARGININE-VASOPRESSIN; TRANSCRIPTION
AB Measurements of changes in pre-mRNA levels by intron-specific probes are generally accepted as more closely reflecting changes in gene transcription rates than are measurements of mRNA levels by exonic probes. This is, in part, because the pre-mRNAs, which include the primary transcript and various splicing intermediates located in the nucleus (also referred to as heteronuclear RNAs, or hnRNAs), are processed rapidly (with half-lives <60 min) as compared to neuropeptide mRNAs, which are then transferred to the cytoplasm and which have much longer half-lives (often over days). In this chapter, we describe the use of exon-and intron-specific probes to evaluate oxytocin (OT) and vasopressin (VP) neuropeptide gene expression by analyses of their mRNAs and hnRNAs by quantitative in situ hybridization (qISH) and also by using specific PCR primers in quantitative, real-time PCR (qPCR) procedures.
C1 [Gainer, Harold; Ponzio, Todd A.] NINDS, Neurochem Lab, NIH, Bethesda, MD 20892 USA.
[Kawasaki, Makoto] Univ Occupat & Environm Hlth, Sch Med, Dept Orthopaed, Kitakyushu, Fukuoka 807, Japan.
[Yue, Chunmei] Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.
RP Gainer, H (reprint author), NINDS, Neurochem Lab, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
FU Intramural NIH HHS [Z99 NS999999]
NR 30
TC 2
Z9 2
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-309-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 789
BP 89
EP 110
DI 10.1007/978-1-61779-310-3_5
D2 10.1007/978-1-61779-310-3
PG 22
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA BYN65
UT WOS:000299454600005
PM 21922402
ER
PT S
AU Park, JJ
Loh, YP
AF Park, Joshua J.
Loh, Y. Peng
BE Merighi, A
TI Visualization of Peptide Secretory Vesicles in Living Nerve Cells
SO NEUROPEPTIDES: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Carboxypeptidase E; Brain-derived neurotrophic factor; Hippocampal
neurons; Peptidergic secretory vesicles; Vesicle trafficking
ID HIPPOCAMPAL-NEURONS; TRANSPORT
AB Analysis of real-time movements of peptidergic vesicles in live neurons provides insight into molecular mechanism(s) supporting the activity-dependent secretion of neurotrophins and neuropeptides. We examined the effect of overexpression of exogenous peptides comprising of the cytoplasmic tail sequence of vesicular carboxypeptidase E (CPE), proposed to be involved in the mechanism of trafficking of peptidergic secretory vesicles, in live hippocampal neurons. E16 rat hippocampal neurons were transfected with the peptidergic vesicle markers, CPE C-terminally tagged with red or green fluorescent protein, or brain-derived neurotrophic factor (BDNF) tagged with green fluorescent protein, and grown on dishes specialized for real-time live cell visualization. Movements of peptidergic vesicles were imaged in a temperature-controlled chamber on a confocal inverted microscope and analyzed with respect to their velocity, displacement distance, and processivity.
C1 [Park, Joshua J.] Univ Toledo, Coll Med, Toledo, OH 43606 USA.
[Loh, Y. Peng] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
RP Park, JJ (reprint author), Univ Toledo, Coll Med, 2801 W Bancroft St, Toledo, OH 43606 USA.
FU Intramural NIH HHS
NR 6
TC 3
Z9 3
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-309-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 789
BP 137
EP 145
DI 10.1007/978-1-61779-310-3_8
D2 10.1007/978-1-61779-310-3
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA BYN65
UT WOS:000299454600008
PM 21922405
ER
PT J
AU Kolenbrander, PE
Periasamy, S
AF Kolenbrander, Paul E.
Periasamy, Saravanan
BE Kolenbrander, PE
TI INTERSPECIES INTERACTIONS PROMOTE MULTISPECIES COMMUNITIES
SO ORAL MICROBIAL COMMUNITIES: GENOMIC INQUIRY AND INTERSPECIES
COMMUNICATION
LA English
DT Article; Book Chapter
ID GINGIVAL EPITHELIAL-CELLS; COAGGREGATION RECEPTOR POLYSACCHARIDES; ORAL
MICROBIAL COMMUNITIES; INITIAL DENTAL BIOFILM; OUTER-MEMBRANE PROTEIN;
PORPHYROMONAS-GINGIVALIS; FUSOBACTERIUM-NUCLEATUM;
STREPTOCOCCUS-GORDONII; TANNERELLA-FORSYTHIA;
ACTINOBACILLUS-ACTINOMYCETEMCOMITANS
C1 [Kolenbrander, Paul E.; Periasamy, Saravanan] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA.
RP Kolenbrander, PE (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA.
NR 137
TC 1
Z9 1
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-710-7
PY 2011
BP 3
EP +
PG 18
WC Dentistry, Oral Surgery & Medicine; Microbiology
SC Dentistry, Oral Surgery & Medicine; Microbiology
GA BYN82
UT WOS:000299465400002
ER
PT J
AU Palmer, RJ
Kolenbrander, PE
AF Palmer, Robert J., Jr.
Kolenbrander, Paul E.
BE Kolenbrander, PE
TI SPATIOTEMPORAL ORGANIZATION OF MULTISPECIES COMMUNITIES IN THE HUMAN
ORAL MICROBIOME
SO ORAL MICROBIAL COMMUNITIES: GENOMIC INQUIRY AND INTERSPECIES
COMMUNICATION
LA English
DT Article; Book Chapter
ID IN-SITU HYBRIDIZATION; INITIAL DENTAL BIOFILM; STREPTOCOCCUS-MUTANS;
PORPHYROMONAS-GINGIVALIS; ACTINOMYCES-NAESLUNDII;
FUSOBACTERIUM-NUCLEATUM; GENE-EXPRESSION;
ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; INTERGENERIC COMMUNICATION;
VIRULENCE TRAITS
C1 [Palmer, Robert J., Jr.; Kolenbrander, Paul E.] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA.
RP Palmer, RJ (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA.
NR 57
TC 0
Z9 0
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-710-7
PY 2011
BP 371
EP +
PG 13
WC Dentistry, Oral Surgery & Medicine; Microbiology
SC Dentistry, Oral Surgery & Medicine; Microbiology
GA BYN82
UT WOS:000299465400026
ER
PT S
AU Maudsley, S
Chadwick, W
Wang, LY
Zhou, Y
Martin, B
Park, SS
AF Maudsley, Stuart
Chadwick, Wayne
Wang, Liyun
Zhou, Yu
Martin, Bronwen
Park, Sung-Soo
BE Luttrell, LM
Ferguson, SSG
TI Bioinformatic Approaches to Metabolic Pathways Analysis
SO SIGNAL TRANSDUCTION PROTOCOLS, THIRD EDITION
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Signaling; Network; Pathway; Phenotype; Receptor
ID DIFFERENTIALLY EXPRESSED GENES; TANDEM MASS-SPECTROMETRY; DIETARY
ENERGY-INTAKE; FALSE DISCOVERY RATE; MICROARRAY DATA; QUANTITATIVE
PROTEOMICS; PROTEIN IDENTIFICATION; NONPARAMETRIC METHODS;
STATISTICAL-ANALYSIS; ESCHERICHIA-COLI
AB The growth and development in the last decade of accurate and reliable mass data collection techniques has greatly enhanced our comprehension of cell signaling networks and pathways. At the same time however, these technological advances have also increased the difficulty of satisfactorily analyzing and interpreting these ever-expanding datasets. At the present time, multiple diverse scientific communities including molecular biological, genetic, proteomic, bioinformatic, and cell biological, are converging upon a common endpoint, that is, the measurement, interpretation, and potential prediction of signal transduction cascade activity from mass datasets. Our ever increasing appreciation of the complexity of cellular or receptor signaling output and the structural coordination of intracellular signaling cascades has to some extent necessitated the generation of a new branch of informatics that more closely associates functional signaling effects to biological actions and even whole-animal phenotypes. The ability to untangle and hopefully generate theoretical models of signal transduction information flow from transmembrane receptor systems to physiological and pharmacological actions may be one of the greatest advances in cell signaling science. In this overview, we shall attempt to assist the navigation into this new field of cell signaling and highlight several methodologies and technologies to appreciate this exciting new age of signal transduction.
C1 [Maudsley, Stuart; Chadwick, Wayne; Wang, Liyun; Zhou, Yu; Park, Sung-Soo] NIA, Receptor Pharmacol Unit, NIH, Baltimore, MD 21224 USA.
[Martin, Bronwen] NIA, Metab Unit, NIH, Baltimore, MD 21224 USA.
RP Maudsley, S (reprint author), NIA, Receptor Pharmacol Unit, NIH, Baltimore, MD 21224 USA.
FU Intramural NIH HHS [Z01 AG000312-08]
NR 60
TC 11
Z9 11
U1 0
U2 3
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-159-8
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 756
BP 99
EP 130
DI 10.1007/978-1-61779-160-4_5
D2 10.1007/978-1-61779-160-4
PG 32
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Cell
Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA BYN63
UT WOS:000299454400005
PM 21870222
ER
PT B
AU Meleth, AD
Raiji, VR
Krishnadev, N
Chew, EY
AF Meleth, Annal D.
Raiji, Veena R.
Krishnadev, Nupura
Chew, Emily Y.
BE Ho, AC
Regillo, CD
TI Therapy of Nonexudative Age-Related Macular Degeneration
SO AGE-RELATED MACULAR DEGENERATION DIAGNOSIS AND TREATMENT
LA English
DT Article; Book Chapter
ID BLUE-MOUNTAINS-EYE; POLYUNSATURATED FATTY-ACIDS; RETINAL-PIGMENT
EPITHELIUM; HIGH-DOSE SUPPLEMENTATION; 3RD NATIONAL-HEALTH; VITAMIN-E;
BETA-CAROTENE; FOLIC-ACID; ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE
C1 [Meleth, Annal D.; Krishnadev, Nupura] NEI, Dept Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA.
[Raiji, Veena R.] George Washington Univ, Dept Ophthalmol, Washington, DC USA.
[Chew, Emily Y.] NEI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA.
RP Meleth, AD (reprint author), NEI, Dept Epidemiol & Clin Applicat, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM echew@nei.nih.gov
NR 98
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-1-4614-0124-7
PY 2011
BP 65
EP 78
DI 10.1007/978-1-4614-0125-4_5
D2 10.1007/978-1-4614-0125-4
PG 14
WC Ophthalmology
SC Ophthalmology
GA BXA98
UT WOS:000295560200005
ER
PT J
AU Kumar, V
Talisman, IJ
Bukhari, O
Razzaghy, J
Malhotra, SV
AF Kumar, Vineet
Talisman, Ian Jamie
Bukhari, Omar
Razzaghy, Jacqueline
Malhotra, Sanjay V.
TI Dual role of ionic liquids as phase transfer catalyst and solvent for
glycosidation reactions
SO RSC ADVANCES
LA English
DT Article
ID BETA-D-GLUCOPYRANOSIDES; ANGELICA-FURCIJUGA; CELLS; CONSTITUENTS;
ADRIAMYCIN; EXTRACTION; EFFICIENT; ROOTS; SALTS
AB This report describes the dual role of ionic liquids as phase transfer catalysts and reaction media in heterogeneous glycosidation reactions. Thorough study using a diverse set of ionic liquids provided insight into the relationship between ionic liquid structure and catalytic activity in these reactions. For example, glycosidation was efficient in ionic liquid 1-hexyl-3-methylimidazolium hexafluorophosphate (HxMIm.PF6), and the O- and S-glycosides were produced exclusively in moderate to good yields. As an outcome of the preliminary screen, a tailored novel ionic liquid, 1-hydroxyhexyl-3-methylimidazolium hexafluorophosphate (HOHxMIm.PF6) was rationally designed to be immiscible with water and traditional organic solvents. This provided an advantage in ionic liquid recycling and product recovery via convenient triphasic extraction. The versatility of this methodology was demonstrated through glycosidation reaction on a wide variety of substrates including phenols (17-79%), thiophenols (24-97%), chalcone (44%), and flavone (50-67%). Furthermore, this study shows that the ionic liquid could be employed for at least three runs without apparent loss in activity.
C1 [Kumar, Vineet; Talisman, Ian Jamie; Bukhari, Omar; Razzaghy, Jacqueline; Malhotra, Sanjay V.] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21702 USA.
RP Kumar, V (reprint author), NCI, Lab Synthet Chem, SAIC Frederick Inc, 1050 Boyles St, Frederick, MD 21702 USA.
EM malhotrasa@mail.nih.gov
FU National Cancer Institute, National Institutes of Health
[HHSN261200800001E]
FX The authors would like to thank the NCI Developmental Therapeutics
Program. This project has been funded in whole or in part with federal
funds from the National Cancer Institute, National Institutes of Health,
under Contract No. HHSN261200800001E.
NR 38
TC 12
Z9 12
U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2011
VL 1
IS 9
BP 1721
EP 1727
DI 10.1039/c1ra00385b
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA 855JT
UT WOS:000297561000014
ER
PT J
AU Marques, A
AF Marques, Adriana
BE Halperin, JJ
TI Chronic Lyme Disease
SO LYME DISEASE: AN EVIDENCE-BASED APPROACH
SE Advances in Molecular and Cellular Microbiology
LA English
DT Article; Book Chapter
ID PLACEBO-CONTROLLED TRIAL; SOLITARY ERYTHEMA MIGRANS;
BURGDORFERI-INFECTED MICE; CHRONIC-FATIGUE-SYNDROME; IV
ANTIBIOTIC-THERAPY; BORRELIA-BURGDORFERI; PERSISTENT SYMPTOMS;
CEFUROXIME AXETIL; FOLLOW-UP; DOUBLE-BLIND
C1 NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Marques, A (reprint author), NIAID, Lab Clin Infect Dis, NIH, 10-11N234 10 Ctr Dr, Bethesda, MD 20892 USA.
NR 91
TC 1
Z9 1
U1 0
U2 2
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-84593-804-8
J9 ADV M C M
PY 2011
IS 20
BP 248
EP 258
D2 10.1079/9781845938048.0000
PG 11
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA BXP04
UT WOS:000296588500017
ER
PT S
AU Billings, S
Kapoor, A
Keil, M
Wood, BJ
Boctor, E
AF Billings, Seth
Kapoor, Ankur
Keil, Matthias
Wood, Bradford J.
Boctor, Emad
BE Dhooge, J
Doyley, MM
TI A hybrid surface/image based approach to facilitate ultrasound/CT
registration
SO MEDICAL IMAGING 2011: ULTRASONIC IMAGING, TOMOGRAPHY, AND THERAPY
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging - Ultrasonic Imaging, Tomography, and
Therapy
CY FEB 13-14, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE ultrasound/CT image fusion; surface registration; image registration;
time-of-flight; time-of-flight calibration; Cumulative Cross Residual
Entropy; Coherent Point Drift
ID IMAGE REGISTRATION; SURGERY
AB Registration of intra-operative ultrasound with preoperative CT is highly desirable as a navigational aid for surgeons and interventional radiologists. Image-based solutions generally achieve poor results due to substantially different image appearance of ultrasound and CT. A method is presented that uses surface information and tracked ultrasound to improve registration results. Tracked ultrasound is combined with surface and image-based registration techniques to register ultrasound to CT. Surface data is acquired using an optically tracked range sensor, for example time-of-flight camera. Range data is registered to CT using robust point-set registration; this registration provides an approximate transformation from tracker to CT coordinates. The ultrasound probe is also optically tracked. The probe position and surface-based registration provide a first estimate for the position of the ultrasound image in CT coordinates. This estimate is subsequently refined by a final image-based registration stage. Initial tests using Coherent Point Drift algorithm for registering surface data to CT show favorable results. Tests using both simulated and real time-of-flight range data have good convergence over a wide initial translation and rotation misalignment domain. Preliminary testing using time-of-flight surface data suggests that surface to CT registration may be useful as an initial guess enabling later more precise (but less robust) image based methods for registering ultrasound images to CT. We believe this method will enable image-based algorithms to robustly converge to an optimal registration solution.
C1 [Billings, Seth; Kapoor, Ankur; Wood, Bradford J.] NIH, Clin Ctr, Bethesda, MD 20892 USA.
RP Billings, S (reprint author), NIH, Clin Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA.
RI Boctor, Emad/I-6597-2012
NR 9
TC 1
Z9 1
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-510-6
J9 PROC SPIE
PY 2011
VL 7968
AR 79680V
DI 10.1117/12.878941
PG 12
WC Optics; Radiology, Nuclear Medicine & Medical Imaging
SC Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BXL94
UT WOS:000296332300030
ER
PT B
AU Pinn, VW
Corry, NH
AF Pinn, Vivian W.
Corry, Nida H.
BE Meleis, AI
Birch, EL
Wachter, SM
TI Women's Health in the Urban Community: National Institutes of Health
Perspective
SO WOMEN'S HEALTH AND THE WORLD'S CITIES
SE City in the Twenty-First Century
LA English
DT Article; Book Chapter
C1 [Pinn, Vivian W.] Howard Univ, Coll Med, Dept Pathol, Washington, DC 20059 USA.
[Pinn, Vivian W.] Tufts Univ, Sch Med, Medford, MA 02155 USA.
[Pinn, Vivian W.] Howard Univ, Sch Med, Washington, DC 20059 USA.
[Pinn, Vivian W.; Corry, Nida H.] NIH, Off Res Womens Hlth, Bethesda, MD 20892 USA.
[Corry, Nida H.] ABT Associates Inc, Cambridge, MA 02138 USA.
RP Pinn, VW (reprint author), NIH, NIH Working Grp Women Biomed Careers, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU UNIV PENNSYLVANIA PRESS
PI PHILADELPHIA
PA 3905 SPRUCE STREET, PHILADELPHIA, PA 19104 USA
BN 978-0-8122-4353-6
J9 CITY 21ST CENTURY
PY 2011
BP 169
EP +
PG 21
WC Urban Studies; Women's Studies
SC Urban Studies; Women's Studies
GA BWL34
UT WOS:000294189300010
ER
PT J
AU Fearon, T
Xie, HC
Cheng, JY
Ning, H
Zhuge, Y
Miller, RW
AF Fearon, Thomas
Xie, Huchen
Cheng, Jason Y.
Ning, Holly
Zhuge, Ying
Miller, Robert W.
TI Patient-specific CT dosimetry calculation: a feasibility study
SO JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
LA English
DT Article
DE CT; radiation dosimetry; treatment planning system; CT organ dose
ID COMPUTED-TOMOGRAPHY EXAMINATIONS; MONTE-CARLO TECHNIQUES;
RADIATION-THERAPY; DOSE ESTIMATION; ANTHROPOMORPHIC PHANTOM;
PEDIATRIC-PATIENTS; ORGAN; CHILDREN; ENERGY; MODELS
AB Current estimation of radiation dose from computed tomography (CT) scans on patients has relied on the measurement of Computed Tomography Dose Index (CTDI) in standard cylindrical phantoms, and calculations based on mathematical representations of "standard man". Radiation dose to both adult and pediatric patients from a CT scan has been a concern, as noted in recent reports. The purpose of this study was to investigate the feasibility of adapting a radiation treatment planning system (RTPS) to provide patient-specific CT dosimetry. A radiation treatment planning system was modified to calculate patient-specific CT dose distributions, which can be represented by dose at specific points within an organ of interest, as well as organ dose-volumes (after image segmentation) for a GE Light Speed Ultra Plus CT scanner. The RTPS calculation algorithm is based on a semi-empirical, measured correction-based algorithm, which has been well established in the radiotherapy community. Digital representations of the physical phantoms (virtual phantom) were acquired with the GE CT scanner in axial mode. Thermoluminescent dosimeter (TLDs) measurements in pediatric anthropomorphic phantoms were utilized to validate the dose at specific points within organs of interest relative to RTPS calculations and Monte Carlo simulations of the same virtual phantoms (digital representation). Congruence of the calculated and measured point doses for the same physical anthropomorphic phantom geometry was used to verify the feasibility of the method. The RTPS algorithm can be extended to calculate the organ dose by calculating a dose distribution point-by-point for a designated volume. Electron Gamma Shower (EGSnrc) codes for radiation transport calculations developed by National Research Council of Canada (NRCC) were utilized to perform the Monte Carlo (MC) simulation. In general, the RTPS and MC dose calculations are within 10% of the TLD measurements for the infant and child chest scans. With respect to the dose comparisons for the head, the RTPS dose calculations are slightly higher (10%-20%) than the TLD measurements, while the MC results were within 10% of the TLD measurements. The advantage of the algebraic dose calculation engine of the RTPS is a substantially reduced computation time (minutes vs. days) relative to Monte Carlo calculations, as well as providing patient-specific dose estimation. It also provides the basis for a more elaborate reporting of dosimetric results, such as patient specific organ dose volumes after image segmentation.
C1 [Fearon, Thomas] Childrens Natl Med Ctr, Dept Diagnost Imaging & Radiol, Washington, DC 20010 USA.
[Fearon, Thomas] Childrens Natl Med Ctr, Childrens Res Inst, Washington, DC 20010 USA.
[Fearon, Thomas] George Washington Univ, Med Ctr, Dept Radiol, Washington, DC 20037 USA.
[Xie, Huchen; Cheng, Jason Y.; Ning, Holly; Zhuge, Ying; Miller, Robert W.] NCI, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA.
RP Fearon, T (reprint author), Childrens Natl Med Ctr, Dept Diagnost Imaging & Radiol, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM tfearon@childrensnational.org
FU National Cancer Institute, NIH
FX The authors would like to thank GE Medical Systems for providing
detailed information of the GE LightSpeed CT scanner. This research was
supported by the Intramural Research Program of the National Cancer
Institute, NIH.
NR 66
TC 1
Z9 1
U1 1
U2 2
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 1526-9914
J9 J APPL CLIN MED PHYS
JI J. Appl. Clin. Med. Phys
PY 2011
VL 12
IS 4
BP 196
EP 209
PG 14
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 849XS
UT WOS:000297159300018
ER
PT J
AU Franquelim, HG
De-Sousa, FF
Veiga, AS
Santos, NC
Castanho, MARB
AF Franquelim, Henri G.
De-Sousa, Filipa F.
Salome Veiga, A.
Santos, Nuno C.
Castanho, Miguel A. R. B.
TI Cationic liposomes are possible drug-delivery systems for HIV fusion
inhibitor sifuvirtide
SO SOFT MATTER
LA English
DT Article
ID MEMBRANES; SELECTIVITY; PROTEIN
AB HIV-1 inhibitor sifuvirtide presents increased affinity for cationic dipalmitoylethyl-phosphatidylcholine (EDPPC) in contrast to viral/raft-mimicking (VRM) membranes. When associated to sifuvirtide, EDPPC-containing vesicles fuse with VRM vesicles. After fusion, the peptide co-localizes on VRM vesicles, indicating an effective delivery and concentration of sifuvirtide towards the viral and lipid raft vicinity.
C1 [Franquelim, Henri G.; De-Sousa, Filipa F.; Salome Veiga, A.; Santos, Nuno C.; Castanho, Miguel A. R. B.] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal.
[Salome Veiga, A.] NCI, Biol Chem Lab, Frederick, MD 21701 USA.
RP Castanho, MARB (reprint author), Univ Lisbon, Fac Med, Inst Med Mol, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM macastanho@fm.ul.pt
RI Santos, Nuno/N-7248-2013;
OI Santos, Nuno/0000-0002-0580-0475; Veiga, Ana Salome/0000-0002-9892-2243
FU Fundacao para a Ciencia e a Tecnologia - Ministerio do Ensino e Ciencia
(FCT-MES; Portugal) [SFRH/BD/39039/2007, PTDC/QUI-BIQ/104787/2008,
PTDC/QUI-BIQ/112929/2009]; GAPIC (Faculdade deMedicina da Universidade
de Lisboa) [201000017]
FX The authors thank FusoGen (Tianjin, P. R. China) for the kind gift of
sifuvirtide, and to Sonia Henriques for the support and helpful
discussions. Fundacao para a Ciencia e a Tecnologia - Ministerio do
Ensino e Ciencia (FCT-MES; Portugal) is acknowledged for funding
(SFRH/BD/39039/2007 grant to H. G. F. and projects
PTDC/QUI-BIQ/104787/2008 and PTDC/QUI-BIQ/112929/2009). F. F. D-S.
thanks GAPIC (Faculdade deMedicina da Universidade de Lisboa) for grant
201000017.
NR 21
TC 3
Z9 3
U1 0
U2 11
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1744-683X
J9 SOFT MATTER
JI Soft Matter
PY 2011
VL 7
IS 23
BP 11089
EP 11092
DI 10.1039/c1sm06553j
PG 4
WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics,
Multidisciplinary; Polymer Science
SC Chemistry; Materials Science; Physics; Polymer Science
GA 848DP
UT WOS:000297029500007
ER
PT S
AU Coxon, B
AF Coxon, Bruce
BE Horton, D
TI LAURANCE DAVID HALL 1938-2009
SO ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 65
SE Advances in Carbohydrate Chemistry and Biochemistry
LA English
DT Biographical-Item; Book Chapter
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA.
RP Coxon, B (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 1
U2 5
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2318
BN 978-0-12-385520-6
J9 ADV CARBOHYD CHEM BI
JI Adv. Carbohydr .Chem. Biochem.
PY 2011
VL 65
BP 11
EP 43
DI 10.1016/B978-0-12-385520-6.00002-9
PG 33
WC Biochemistry & Molecular Biology; Chemistry, Organic
SC Biochemistry & Molecular Biology; Chemistry
GA BWJ53
UT WOS:000294028700002
ER
PT J
AU Camphausen, KA
Wang, M
Graves, C
Corn, BW
Muanza, TM
Howard, SP
Mahadevan, A
Schultz, CJ
Haas, ML
Mehta, MP
AF Camphausen, K. A.
Wang, M.
Graves, C.
Corn, B. W.
Muanza, T. M.
Howard, S. P.
Mahadevan, A.
Schultz, C. J.
Haas, M. L.
Mehta, M. P.
TI Predictive Value of Tumor Recurrence Using Urinary Vascular Endothelial
Growth Factor Levels in Patients Receiving Radiation Therapy for
Glioblastoma
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Camphausen, K. A.; Graves, C.] NCI, NIH, Bethesda, MD 20892 USA.
[Wang, M.] RTOG Stat Ctr, Philadelphia, PA USA.
[Corn, B. W.] Tel Aviv Med Ctr & Sch Med, Tel Aviv, Israel.
[Muanza, T. M.] McGill Univ, Montreal, PQ, Canada.
[Howard, S. P.] Univ Wisconsin Hosp, Madison, WI USA.
[Mahadevan, A.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA.
[Schultz, C. J.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Haas, M. L.] Reading Hosp Med Ctr, W Reading, PA USA.
[Mehta, M. P.] NW Mem Hosp, Chicago, IL 60611 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S181
EP S181
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700364
ER
PT J
AU Horton, JA
Sworder, B
Kuznetsov, S
Chung, E
Robey, PG
Citrin, DE
AF Horton, J. A.
Sworder, B.
Kuznetsov, S.
Chung, E.
Robey, P. G.
Citrin, D. E.
TI Macrophages Mediate Bone Marrow Stromal Cell Homing to Irradiated Sites
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Horton, J. A.; Chung, E.; Citrin, D. E.] Nat Canc Inst, Rad Onc Branch, Bethesda, MD USA.
[Sworder, B.; Kuznetsov, S.; Robey, P. G.] Nat Inst Dent & Craniofacial Res, Bethesda, MD USA.
RI Robey, Pamela/H-1429-2011
OI Robey, Pamela/0000-0002-5316-5576
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S703
EP S703
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701529
ER
PT J
AU Kesarwala, AH
Pfalzer, LA
O'Meara, WP
Stout, NL
AF Kesarwala, A. H.
Pfalzer, L. A.
O'Meara, W. P.
Stout, N. L.
TI The Relationship of Post-operative Breast Radiation Therapy to Physical
Function
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Kesarwala, A. H.] NCI, Bethesda, MD 20892 USA.
[Pfalzer, L. A.] Univ Michigan Flint, Flint, MI USA.
[O'Meara, W. P.; Stout, N. L.] Natl Naval Med Ctr, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S216
EP S216
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700438
ER
PT J
AU Kil, W
Lita, E
Gordon, I
Tandle, A
Tofilon, P
Camphausen, K
AF Kil, W.
Lita, E.
Gordon, I.
Tandle, A.
Tofilon, P.
Camphausen, K.
TI Levetiracetam Sensitizes Glioblastoma Multiforme Cells to Temozolomide
Plus Radiation Therapy
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Kil, W.; Lita, E.; Gordon, I.; Tandle, A.; Tofilon, P.; Camphausen, K.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S25
EP S25
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700049
ER
PT J
AU Ko, CJ
Menard, C
Ning, H
Lita, E
Smith, S
Pinto, P
Singh, AK
Coleman, C
Camphausen, K
Kaushal, A
AF Ko, C. J.
Menard, C.
Ning, H.
Lita, E.
Smith, S.
Pinto, P.
Singh, A. K.
Coleman, C.
Camphausen, K.
Kaushal, A.
TI Intrarectal Amifostine Suspension During External Beam Radiotherapy For
Prostate Cancer May Protect Against Long-term Toxicity
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Ko, C. J.; Ning, H.; Lita, E.; Smith, S.; Pinto, P.; Coleman, C.; Camphausen, K.; Kaushal, A.] NCI, Bethesda, MD 20892 USA.
[Menard, C.] Univ Toronto, Toronto, ON, Canada.
[Singh, A. K.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S443
EP S443
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700913
ER
PT J
AU Lamart, S
Morton, LM
Simon, SL
Curtis, RE
Aleman, BMP
Smith, SA
Weathers, RE
Stovall, M
AF Lamart, S.
Morton, L. M.
Simon, S. L.
Curtis, R. E.
Aleman, B. M. P.
Smith, S. A.
Weathers, R. E.
Stovall, M.
TI Radiation Doses to the Esophagus from Radiotherapy Treatment for Breast
Cancer during 1943-2001
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Lamart, S.; Morton, L. M.; Simon, S. L.; Curtis, R. E.] NCI, NIH, Rockville, MD USA.
[Aleman, B. M. P.] Netherlands Canc Inst, Amsterdam, Netherlands.
[Smith, S. A.; Weathers, R. E.; Stovall, M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S250
EP S250
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700508
ER
PT J
AU Levendag, PC
Keskin-Cambay, F
Teguh, DN
El-Gantiry, M
Wildeman, MA
de Pan, C
Vikram, B
Abdel-Wahab, M
Rosenblatt, E
AF Levendag, P. C.
Keskin-Cambay, F.
Teguh, D. N.
El-Gantiry, M.
Wildeman, M. A.
de Pan, C.
Vikram, B.
Abdel-Wahab, M.
Rosenblatt, E.
TI Brachytherapy, a Highly Focused Technique for Applying High Booster
Doses of Radiation. Question: Can it be of Value in Reducing the Local
Relapse Rate in Advanced Cancer of the Nasopharynx?
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Levendag, P. C.; Keskin-Cambay, F.; Teguh, D. N.; de Pan, C.] Erasmus MC Daniel den Hoed Canc Ctr, NL-3075 EA Rotterdam, Netherlands.
[El-Gantiry, M.] Data Ctr Cairo Data Anal Prospect Randomized Tria, Cairo, Egypt.
[Wildeman, M. A.] Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands.
[Vikram, B.] NIH, Washington, WA USA.
[Abdel-Wahab, M.] Data Ctr Cairo Data Anal Prospect Randomized Tria, Cairo, Egypt.
[Rosenblatt, E.] IAEA, Appl Radiat Biol & Radiotherapy Div Human Hlth, A-1400 Vienna, Austria.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S510
EP S511
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701128
ER
PT J
AU Lok, B
Khan, S
Mutter, R
Fields, R
Kraus, D
Pfister, D
Busam, K
Brownell, I
Coit, D
Lee, N
AF Lok, B.
Khan, S.
Mutter, R.
Fields, R.
Kraus, D.
Pfister, D.
Busam, K.
Brownell, I.
Coit, D.
Lee, N.
TI Selective Radiotherapy for the Treatment of Head and Neck Merkel Cell
Carcinoma
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Lok, B.; Khan, S.; Mutter, R.; Fields, R.; Kraus, D.; Pfister, D.; Busam, K.; Coit, D.; Lee, N.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Brownell, I.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S544
EP S545
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701196
ER
PT J
AU Matsuo, M
Miwa, K
Shinoda, J
Tanaka, O
Krishna, M
AF Matsuo, M.
Miwa, K.
Shinoda, J.
Tanaka, O.
Krishna, M.
TI Impact of C11-methionine Positron Emission Tomography (PET) for
Malignant Glioma in Radiation Therapy: Is C11-methionine PET a superior
to Magnetic Resonance Imaging?
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Matsuo, M.; Krishna, M.] NIH, Bethesda, MD 20892 USA.
[Matsuo, M.; Miwa, K.; Tanaka, O.] Kizawa Mem Hosp, Minokanio, Japan.
[Shinoda, J.] Chubu Med Ctr Prolonged Traumat Brain Dysfunct, Minokamo, Japan.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S182
EP S182
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700365
ER
PT J
AU Mulhern, JP
Fitzgerald, T
Bosch, W
Chen, J
Siegel, E
Jamijian, A
O'Meara, E
Freymann, J
Kirby, J
Purdy, J
AF Mulhern, J. P.
Fitzgerald, T.
Bosch, W.
Chen, J.
Siegel, E.
Jamijian, A.
O'Meara, E.
Freymann, J.
Kirby, J.
Purdy, J.
TI Bioinformatics Support of Cross Correlation of Images with RT Objects
and Clinical Meta-data
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Mulhern, J. P.; Jamijian, A.] Booz Allen Hamilton, Rockville, MD USA.
[Fitzgerald, T.] Univ Massachusetts, Amherst, MA 01003 USA.
[Bosch, W.] Washington Univ, St Louis, MO USA.
[Chen, J.; Siegel, E.] Univ Maryland, Baltimore, MD 21201 USA.
[O'Meara, E.] Radiat Therapy Oncol Grp, Philadelphia, PA USA.
[Freymann, J.; Kirby, J.] NCI, Canc Imaging Program, Rockville, MD USA.
[Purdy, J.] Univ Calif Davis, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S160
EP S160
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700321
ER
PT J
AU Niu, Y
Han-Oh, S
Parke, WC
Yi, B
Yu, CX
AF Niu, Y.
Han-Oh, S.
Parke, W. C.
Yi, B.
Yu, C. X.
TI Geometric and Dosimetric Verification of Four-dimensional Intensity
Modulated Arc Therapy
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Niu, Y.; Yi, B.; Yu, C. X.] Univ Maryland, Sch Med, Dept Radiat Oncol, Baltimore, MD 21201 USA.
[Niu, Y.; Parke, W. C.] George Washington Univ, Dept Phys, Washington, DC 20052 USA.
[Han-Oh, S.] NCI, NIH, Bethesda, MD 20892 USA.
NR 2
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S894
EP S894
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701928
ER
PT J
AU Ray, GL
Baidoo, K
Keller, L
Milenic, D
Brechbiel, M
AF Ray, G. L.
Baidoo, K.
Keller, L.
Milenic, D.
Brechbiel, M.
TI Pre-clinical Evaluation of Lu-177-Labeled Trastuzumab Targeting HER2 for
Radioimmunotherapeutic and Radioimmunodiagnostic Applications
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Ray, G. L.; Baidoo, K.; Keller, L.; Milenic, D.; Brechbiel, M.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S743
EP S743
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701611
ER
PT J
AU Rosenblatt, E
El-Gantiry, M
Elattar, I
Afiane, M
Benjafaar, N
Abubaker, S
Chansilpa, Y
Vikram, B
Abdel-Wahab, M
Levendag, P
AF Rosenblatt, E.
El-Gantiry, M.
Elattar, I.
Afiane, M.
Benjafaar, N.
Abubaker, S.
Chansilpa, Y.
Vikram, B.
Abdel-Wahab, M.
Levendag, P.
TI Brachytherapy Boost in Loco-regionally Advanced Nasopharyngeal
Carcinoma: A Prospective Randomized Trial of the International Atomic
Energy Agency
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Rosenblatt, E.; Abdel-Wahab, M.] IAEA, A-1400 Vienna, Austria.
[El-Gantiry, M.; Elattar, I.] Cairo Univ, Natl Canc Inst, Cairo, Egypt.
[Afiane, M.] Ctr Hosp Univ Mustafa CHU, Ctr Pierre & Marie Curie, Dept Radiotherapie, Algiers, Algeria.
[Benjafaar, N.] Inst Natl Oncol, Rabat, Morocco.
[Abubaker, S.] Pakistan Atom Energy Commiss, Inst Nucl Med & Oncol, Lahore, Pakistan.
[Chansilpa, Y.] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand.
[Vikram, B.] NCI, Bethesda, MD 20892 USA.
[Abdel-Wahab, M.] Cleveland Clin, Taussig Comprehens Canc Ctr, Cleveland, OH 44106 USA.
[Levendag, P.] Erasmus Univ, Rotterdam, Netherlands.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S4
EP S5
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700008
ER
PT J
AU Simone, B
Simone, CB
Dan, TD
Ly, D
Lita, E
Smith, S
Levine, S
Folio, L
Simone, NL
AF Simone, B.
Simone, C. B.
Dan, T. D.
Ly, D.
Lita, E.
Smith, S.
Levine, S.
Folio, L.
Simone, N. L.
TI Lack of Radiation-induced Pulmonary Toxicity 25 years after Treatment
with Breast Conservation Therapy or Mastectomy for Early-stage Breast
Cancer: Results from the NCI Randomized Trial
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Simone, B.] Touro Coll Osteopath Med, New York, NY USA.
[Simone, B.; Simone, C. B.; Dan, T. D.; Ly, D.; Lita, E.; Smith, S.; Simone, N. L.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
[Levine, S.] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA.
[Folio, L.] Clin Res Ctr, Bethesda, MD USA.
[Simone, N. L.] Thomas Jefferson Univ Hosp, Dept Radiat Oncol, Philadelphia, PA 19107 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S6
EP S7
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700012
ER
PT J
AU Simone, B
Simone, CB
Dan, TD
Ly, D
Lita, E
Smith, S
Levine, S
Folio, L
Simone, NL
AF Simone, B.
Simone, C. B.
Dan, T. D.
Ly, D.
Lita, E.
Smith, S.
Levine, S.
Folio, L.
Simone, N. L.
TI Long-term Update of US GI Intergroup RTOG 98-11 Phase III Trial for Anal
Carcinoma: Concurrent Chemoradiation with 5-FU-mitomycin Yields Better
Disease-free and Overall Survival than 5-FU-cisplatin
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Simone, B.] Touro Coll Osteopath Med, New York, NY USA.
[Simone, B.; Simone, C. B.; Dan, T. D.; Ly, D.; Lita, E.; Smith, S.; Simone, N. L.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
[Levine, S.] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA.
[Folio, L.] Clin Res Ctr, Bethesda, MD USA.
[Simone, N. L.] Thomas Jefferson Univ Hosp, Dept Radiat Oncol, Philadelphia, PA 19107 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S5
EP S6
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700010
ER
PT J
AU Simone, CB
Stewart, DM
Lita, E
Kreitman, RJ
Conlon, K
Janik, JE
Morris, JC
Kaushal, A
AF Simone, C. B.
Stewart, D. M.
Lita, E.
Kreitman, R. J.
Conlon, K.
Janik, J. E.
Morris, J. C.
Kaushal, A.
TI Radiation Therapy for Management of Patients with HTLV-1-associated
Adult T-cell Leukemia/Lymphoma
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Simone, C. B.; Stewart, D. M.; Lita, E.; Kreitman, R. J.; Conlon, K.; Janik, J. E.; Morris, J. C.; Kaushal, A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S630
EP S631
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701375
ER
PT J
AU Simone, CB
O'Connell, J
Both, S
Mansueti, JR
Christodouleas, J
Deville, C
McDonough, J
Vapiwala, N
Efstathiou, JA
Bekelman, JA
AF Simone, C. B.
O'Connell, J.
Both, S.
Mansueti, J. R.
Christodouleas, J.
Deville, C.
McDonough, J.
Vapiwala, N.
Efstathiou, J. A.
Bekelman, J. A.
TI Para-aortic Nodal Clinical Target Volume Delineation in the Era of
Particle Therapy
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Simone, C. B.] NCI, Bethesda, MD 20892 USA.
[O'Connell, J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Both, S.; Christodouleas, J.; Deville, C.; McDonough, J.; Vapiwala, N.; Bekelman, J. A.] Hosp Univ Penn, Philadelphia, PA 19104 USA.
[Mansueti, J. R.] Natl Naval Med Ctr, Bethesda, MD USA.
[Efstathiou, J. A.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
RI Deville, Curtiland/B-2819-2013
OI Deville, Curtiland/0000-0003-4846-6486
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S451
EP S451
PG 1
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411701001
ER
PT J
AU Youn, P
Howlader, N
Milano, MT
Constine, LS
Travis, LB
AF Youn, P.
Howlader, N.
Milano, M. T.
Constine, L. S.
Travis, L. B.
TI Long-term Cause-specific Mortality of Adolescent and Young Adult (AYA)
Survivors of Bone and Soft Tissue Sarcoma (STS): A Population-based
Study
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
C1 [Youn, P.; Milano, M. T.; Constine, L. S.; Travis, L. B.] Univ Rochester, Sch Med & Dent, Dept Radiat Oncol, Rochester, NY USA.
[Howlader, N.] NCI, Surveillance Res Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PY 2011
VL 81
IS 2
SU S
BP S137
EP S138
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 840AX
UT WOS:000296411700277
ER
PT J
AU Biassoni, R
Coligan, JE
Moretta, L
AF Biassoni, Roberto
Coligan, John E.
Moretta, Lorenzo
TI Natural Killer Cells in Healthy and Diseased Subjects
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Editorial Material
ID CLASS-I MOLECULES; HLA-C; RECEPTORS; RECOGNITION; CLONING; MOUSE; LYSIS;
SELF
C1 [Biassoni, Roberto; Moretta, Lorenzo] Inst Giannina Gaslini, Dept Expt Med, I-16147 Genoa, Italy.
[Coligan, John E.] NIAID, Receptor Cell Biol Sect, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
RP Biassoni, R (reprint author), Inst Giannina Gaslini, Dept Expt Med, I-16147 Genoa, Italy.
EM robertobiassoni@ospedale-gaslini.ge.it
NR 33
TC 0
Z9 0
U1 0
U2 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 795251
DI 10.1155/2011/795251
PG 4
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 845JP
UT WOS:000296819100001
ER
PT J
AU Monsurro, V
Marincola, FM
AF Monsurro, Vladia
Marincola, Francesco M.
TI Microarray Analysis for a Comprehensive Immunological-Status Evaluation
during Cancer Vaccine Immune Monitoring
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID CD8(+) T-CELLS; IMMUNIZATION; IMMUNOTHERAPY; LYMPHOCYTES; MELANOMA
AB Anticancer immune responses can be enhanced by immune intervention that promotes complex biological mechanisms involving several cellular populations. The classical immune monitoring for biological-based cancer clinical trials is often based on single-cell analysis. However, the overall effect could be lost by such a reductionist approach explaining the lack of correlation among clinical and immunological endpoints often reported. Microarray technology could give the possibility of studying in a multiparametric setting the immune therapy effects. The application of microarray is leading to an improved understanding of the immune responses to tumor immunotherapy. In fact, analysis of cancer vaccine-induced host responses using microarrays is proposed as valuable alternative to the standard cell-based methods. This paper shows successful examples of how high-throughput gene expression profiling contributed to the understanding of anticancer immune responses during biological therapy, introducing as well the integrative platforms that allow the network analysis in molecular biology studies.
C1 [Monsurro, Vladia] Univ Verona, Sch Med, Dept Pathol & Diagnost, I-37100 Verona, Italy.
[Monsurro, Vladia] Azienda Osped Univ Integrata, Verona, Italy.
[Marincola, Francesco M.] NIH, Infect Dis & Immunogenet Sect, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Monsurro, V (reprint author), Univ Verona, Sch Med, Dept Pathol & Diagnost, I-37100 Verona, Italy.
EM vmonsurro@gmail.com
FU AIRC; Italian Ministry of Health
FX The authors are thankful to Dr. Silvia Coin and Miss Svjetlana Raus for
help in proofreading the paper. V. Monsurro was financed by grants from
AIRC and Italian Ministry of Health and SC is recipient of an Italian
Ministry of Health fellowship.
NR 19
TC 2
Z9 2
U1 0
U2 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 307297
DI 10.1155/2011/307297
PG 4
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 845HS
UT WOS:000296814200001
ER
PT J
AU Leiva-Salcedo, E
Coddou, C
Rodriguez, FE
Penna, A
Lopez, X
Neira, T
Fernandez, R
Imarai, M
Rios, M
Escobar, J
Montoya, M
Huidobro-Toro, JP
Escobar, A
Acuna-Castillo, C
AF Leiva-Salcedo, Elias
Coddou, Claudio
Rodriguez, Felipe E.
Penna, Antonello
Lopez, Ximena
Neira, Tanya
Fernandez, Ricardo
Imarai, Monica
Rios, Miguel
Escobar, Jorge
Montoya, Margarita
Pablo Huidobro-Toro, J.
Escobar, Alejandro
Acuna-Castillo, Claudio
TI Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID RAT SUBMANDIBULAR-GLAND; P2X(7) RECEPTOR; BACTERIAL LIPOPOLYSACCHARIDE;
PORE FORMATION; TOLL-LIKE; SIGNAL-TRANSDUCTION; NLRP3 INFLAMMASOME;
IL-1-BETA RELEASE; DANGER SIGNAL; CA2+ INFLUX
AB The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced responses. Moreover, a C-terminal binding site for LPS has been proposed. In order to evaluate if LPS can directly modulate the activity of the P2X7R, we tested several signaling pathways associated with P2X7R activation in HEK293 cells that do not express the TLR-4 receptor. We found that LPS alone was unable to induce any P2X7R-related activity, suggesting that the P2X7R is not directly activated by the endotoxin. On the other hand, preapplication of LPS inhibited ATP-induced currents, intracellular calcium increase, and ethidium bromide uptake and had no effect on ERK activation in HEK293 cells. In splenocytes-derived T-regulatory cells, in which ATP-induced apoptosis is driven by the P2X7R, LPS inhibited ATP-induced apoptosis. Altogether, these results demonstrate that LPS modulates the activity of the P2X7R and suggest that this effect could be of physiological relevance.
C1 [Rodriguez, Felipe E.; Lopez, Ximena; Neira, Tanya; Imarai, Monica; Rios, Miguel; Montoya, Margarita; Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Dept Biol, Fac Quim & Biol, Santiago, Chile.
[Rodriguez, Felipe E.; Lopez, Ximena; Neira, Tanya; Imarai, Monica; Rios, Miguel; Montoya, Margarita; Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Ctr Biotecnol Acuicola, Santiago, Chile.
[Leiva-Salcedo, Elias; Penna, Antonello] Univ Chile, Fac Med, Celula Inst Ciencias Biomed, Ctr Fondap Estudios Mol, Santiago, Chile.
[Coddou, Claudio] NICHD, Sect Cellular Signaling, PDN, Bethesda, MD USA.
[Fernandez, Ricardo] Univ Andres Bello, Fac Ciencias Biol, Santiago, Chile.
[Fernandez, Ricardo] Univ Andres Bello, Fac Med, Santiago, Chile.
[Escobar, Jorge] PUCV, Fac Ciencias, Inst Quim, Valparaiso, Chile.
[Pablo Huidobro-Toro, J.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Regulac Celular & Patol JV Luco, Santiago, Chile.
[Pablo Huidobro-Toro, J.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Santiago, Chile.
[Escobar, Alejandro] Univ Chile, Fac Odontol, Dept Ciencias Basicas & Comunitarias, Santiago, Chile.
[Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Fac Ciencias Med, Santiago, Chile.
RP Acuna-Castillo, C (reprint author), Univ Santiago Chile USACH, Dept Biol, Fac Quim & Biol, Santiago, Chile.
EM claudio.acuna@usach.cl
RI Escobar, Alejandro/I-2775-2013
FU FONDECYT [11070117]; DICYT USACH; PBCT; Center for Molecular Studies of
the Cell, FONDAP [15010006]; National Institutes of Health National
Institute of Child Health and Human Development; J. V. Luco Center for
Cell Regulation and Pathology
FX The authors thank Dr. Stanko Stojilkovic and Dr. Andres Stutzin for the
critical review of this paper, Dra Marcela Hermoso for TLR-4 antibody,
Dr. Jaime Eugenin for A74003, Manuela Jimenez, Felipe Reyes, Belgica
Villegas, Yohana Labra, Carolina Beltran, and Gino Nardocci for
technical assistance. This work was funded by FONDECYT 11070117, DICYT
USACH, and PBCT. A. Penna and E. leiva. Salcedo were funded by the
Center for Molecular Studies of the Cell, FONDAP 15010006. C. Coddou was
funded by the Intramural Research Program of the National Institutes of
Health National Institute of Child Health and Human Development. J. P.
Huidobro-Toro was supported by the J. V. Luco Center for Cell Regulation
and Pathology; the Millennium Institute for Fundamental and Applied
Biology (MIFAB) also contributed to the Center's funding. This work is
in memory of Alfonso Salinas, Ricardo Castillo and Ruth Quiroz I.
Special thanks go to Mr. George Montgomery for proofreading the paper.
E. Leiva-Salcedo, C. Coddou, and F. E. Rodriguez contributed equally to
this work.
NR 59
TC 3
Z9 3
U1 0
U2 12
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0962-9351
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2011
AR 152625
DI 10.1155/2011/152625
PG 12
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 845JL
UT WOS:000296818700001
ER
PT S
AU Antani, S
Xue, ZY
Long, LR
Bennett, D
Ward, S
Thoma, GR
AF Antani, Sameer
Xue, Zhiyun
Long, L. Rodney
Bennett, Deborah
Ward, Sarah
Thoma, George R.
BE Boonn, WW
Liu, BJ
TI Is there a need for biomedical CBIR systems in clinical practice?
Outcomes from a usability study
SO MEDICAL IMAGING 2011: ADVANCED PACS-BASED IMAGING INFORMATICS AND
THERAPEUTIC APPLICATIONS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging - Advanced PACS-based Imaging Informatics
and Therapeutic Applications
CY FEB 16-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE content-based image retrieval; usability study; medical image analysis
system; uterine cervix image
AB Articles in the literature routinely describe advances in Content Based Image Retrieval (CBIR) and its potential for improving clinical practice, biomedical research and education. Several systems have been developed to address particular needs, however, surprisingly few are found to be in routine practical use. Our collaboration with the National Cancer Institute (NCI) has identified a need to develop tools to annotate and search a collection of over 100,000 cervigrams and related, anonymized patient data. One such tool developed for a projected need for retrieving similar patient images is the prototype CBIR system, called CervigramFinder, which retrieves images based on the visual similarity of particular regions on the cervix. In this article we report the outcomes from a usability study conducted at a primary meeting of practicing experts. We used the study to not only evaluate the system for software errors and ease of use, but also to explore its "user readiness", and to identify obstacles that hamper practical use of such systems, in general. Overall, the participants in the study found the technology interesting and bearing great potential; however, several challenges need to be addressed before the technology can be adopted.
C1 [Antani, Sameer; Xue, Zhiyun; Long, L. Rodney; Bennett, Deborah; Ward, Sarah; Thoma, George R.] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
RP Antani, S (reprint author), NIH, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
OI Antani, Sameer/0000-0002-0040-1387
NR 11
TC 1
Z9 1
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-509-0
J9 PROC SPIE
PY 2011
VL 7967
AR 796708
DI 10.1117/12.878268
PG 7
WC Optics; Radiology, Nuclear Medicine & Medical Imaging
SC Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BXL91
UT WOS:000296329700006
ER
PT J
AU Chun, JH
Pike, VW
AF Chun, Joong-Hyun
Pike, Victor W.
TI Single-step radiosyntheses of no-carrier-added [F-18]benzaldehydes and
[F-18]benzyl halides from [F-18]fluoride ion and diaryliodonium salt
precursors
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
ID ROUTE
C1 [Chun, Joong-Hyun; Pike, Victor W.] NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA.
NR 6
TC 1
Z9 1
U1 1
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S482
EP S482
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600482
ER
PT J
AU Chun, JH
Morse, CL
Chin, FT
Pike, VW
AF Chun, Joong-Hyun
Morse, Cheryl L.
Chin, Frederick T.
Pike, Victor W.
TI No-carrier-added radiosyntheses of [F-18]fluoroarenes from diaryl
sulfoxides and [F-18]fluoride ion
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Chun, Joong-Hyun; Morse, Cheryl L.; Pike, Victor W.] NIMH, Mol Imaging Branch, NIH Bethesda, Bethesda, MD 20892 USA.
[Chin, Frederick T.] Stanford Univ, Dept Radiol, Sch Med, MIPS, Stanford, CA 94305 USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S70
EP S70
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600071
ER
PT J
AU Donohue, SR
Terry, G
Zoghbi, SS
Innis, RB
Halldin, C
Pike, VW
AF Donohue, Sean R.
Terry, Garth
Zoghbi, Sami S.
Innis, Robert B.
Halldin, Christer
Pike, Victor W.
TI A new chemotype of CB1 receptor PET radioligand with fast brain kinetics
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Donohue, Sean R.; Terry, Garth; Zoghbi, Sami S.; Innis, Robert B.; Pike, Victor W.] NIMH, Mol Imaging Branch, Bethesda, MD 20892 USA.
[Donohue, Sean R.; Halldin, Christer] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden.
NR 2
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S280
EP S280
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600280
ER
PT J
AU Falguni, B
Wu, HT
Li, CH
Shi, ZD
Agnieszka, S
Gary, LG
AF Falguni, Basuli
Wu Haitao
Li Changhui
Shi Zhen-Dan
Agnieszka, Sulima
Gary, Griffiths L.
TI A First Synthesis of [F-18]Lapatinib: A Potential Tracer for Positron
Emission Tomographic Imaging of ErbB1/ErbB2 Tyrosine Kinase Activity
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Falguni, Basuli; Wu Haitao; Li Changhui; Shi Zhen-Dan; Agnieszka, Sulima; Gary, Griffiths L.] NHLBI, Imaging Probe Dev Ctr, NIH, Rockville, MD USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S474
EP S474
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600474
ER
PT J
AU Jagoda, E
Bhadrasetty, V
Lang, LX
Williams, M
Histed, S
Kramer-Marek, G
Marik, J
Tinianow, J
Merchant, M
Szajek, L
Paik, C
Bottaro, D
Choyke, P
AF Jagoda, Elaine
Bhadrasetty, Veerendra
Lang Lixin
Williams, Mark
Histed, Stephanie
Kramer-Marek Gabriela
Marik, Jan
Tinianow, Jeff
Merchant, Mark
Szajek, Lawrence
Paik, Chang
Bottaro, Donald
Choyke, Peter
TI Comparison of [Zr-89] and [Br-76] labeled MetMAb, a one-armed monoclonal
antibody targeting the Met receptor tyrosine kinase (Met), in human
gastric carcinoma (MKN-45) and glioblastoma (U87 MG) cells and
xenografts
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Jagoda, Elaine; Bhadrasetty, Veerendra; Williams, Mark; Histed, Stephanie; Kramer-Marek Gabriela; Choyke, Peter] NCI, Mol Imaging Program, NIH Bethesda, Bethesda, MD 20892 USA.
[Lang Lixin] NIBIB, Radiochem Grp, NIH, Bethesda, MD USA.
[Marik, Jan; Tinianow, Jeff; Merchant, Mark] Genentech Inc, San Francisco, CA USA.
[Szajek, Lawrence] NIH, PET Dept, CC, Bethesda, MD 20892 USA.
[Paik, Chang] NIH, NMD, Rad&IS, CC, Bethesda, MD 20892 USA.
[Bottaro, Donald] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA.
RI Bottaro, Donald/F-8550-2010
OI Bottaro, Donald/0000-0002-5057-5334
NR 2
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S172
EP S172
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600172
ER
PT J
AU Kang, CM
Lee, I
Yoon, KY
Yi, KY
Yoo, SE
Lin, X
Chen, XY
Kim, JY
Choe, YS
AF Kang, Choong Mo
Lee, Iljung
Yoon, Kwang Yup
Yi, Kyu Yang
Yoo, Sung-eun
Lin Xin
Chen Xiaoyuan
Kim, Jung Young
Choe, Yearn Seong
TI Evaluation of KR-31831, an angiogenesis inhibitor using
Cu-64-DOTA-VEGF(121)
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Kang, Choong Mo; Lee, Iljung; Yoon, Kwang Yup; Choe, Yearn Seong] Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea.
[Yi, Kyu Yang; Yoo, Sung-eun] KRICT, Taejon, South Korea.
[Lin Xin; Chen Xiaoyuan] NIBIB, NIH, Bethesda, MD USA.
[Kim, Jung Young] KIRAMS, Seoul, South Korea.
NR 2
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S133
EP S133
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600134
ER
PT J
AU Kiesewetter, DO
Gao, HK
Niu, G
Ma, Y
Ahn, JM
Chen, XY
AF Kiesewetter, Dale O.
Gao Haokao
Niu Gang
Ma Ying
Ahn Jung-Mo
Chen Xiaoyuan
TI Evaluation of a peptide ligand for targeting of GLP-1R in vivo
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
ID RECEPTOR
C1 [Kiesewetter, Dale O.; Gao Haokao; Niu Gang; Ma Ying; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA.
[Gao Haokao] Fourth Mil Med Univ, Dept Cardiol, Xian 710032, Peoples R China.
[Ahn Jung-Mo] Univ Texas Dallas, Dept Chem, Dallas, TX 75230 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S29
EP S29
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600030
ER
PT J
AU Lang, LX
Li, WH
Ma, Y
Niu, G
Kiesewetter, DO
Chen, XY
AF Lang Lixin
Li Weihua
Ma Ying
Niu Gang
Kiesewetter, Dale O.
Chen Xiaoyuan
TI [F-18]-N-succinimidyl 4-fluoromethylbenzoate labeled RGDyK dimer for
imaging alpha(v)beta(3) integrin expression
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Lang Lixin; Li Weihua; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA.
[Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S205
EP S205
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600205
ER
PT J
AU Lang, LX
Li, WH
Guo, N
Ma, Y
Niu, G
Kiesewetter, DO
Chen, XY
AF Lang Lixin
Li Weihua
Guo Ning
Ma Ying
Niu Gang
Kiesewetter, Dale O.
Chen Xiaoyuan
TI Comparison study of [F-18]FAl-NOTA-PRGD2, [F-18]-FPPRDG2 and
[Ga-68]-NOTA-PRGD2 for PET imaging of U87MG xenograft model
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Lang Lixin; Li Weihua; Guo Ning; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA.
[Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S88
EP S88
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600089
ER
PT J
AU Li, WH
Lang, LX
Ma, Y
Niu, G
Kiesewetter, DO
Chen, XY
AF Li Weihua
Lang Lixin
Ma Ying
Niu Gang
Kiesewetter, Dale O.
Chen Xiaoyuan
TI [F-18]-labeled c-Met binding peptides for tumor imaging
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Li Weihua; Lang Lixin; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA.
[Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China.
NR 3
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S206
EP S206
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600206
ER
PT J
AU Mathe, D
Horvath, I
Szigeti, K
Donohue, SR
Gulyas, B
Agoston, D
Palkovits, M
Freund, TF
Ledent, C
Pike, VW
Halldin, C
AF Mathe, Domokos
Horvath, Ildiko
Szigeti, Krisztian
Donohue, Sean R.
Gulyas, Balazs
Agoston, Denes
Palkovits, Miklos
Freund, Tamas F.
Ledent, Catherine
Pike, Victor W.
Halldin, Christer
TI In vivo SPECT and ex vivo autoradiographic imaging of the CB1 receptor
radioligand [I-125]SD7015 in mouse brain
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Mathe, Domokos; Horvath, Ildiko; Szigeti, Krisztian] CROmed Res Ltd, Budapest, Hungary.
[Donohue, Sean R.; Pike, Victor W.] NIMH, NIH, Bethesda, MD 20892 USA.
[Gulyas, Balazs; Agoston, Denes; Halldin, Christer] Karolinska Inst, Stockholm, Sweden.
[Palkovits, Miklos] Semmelweis Univ, Dept Anat, H-1085 Budapest, Hungary.
[Freund, Tamas F.] Inst Expt Med HAS, Budapest, Hungary.
[Ledent, Catherine] Univ Libre Brussels, IRIBHM, Brussels, Belgium.
RI Palkovits, Miklos/F-2707-2013
NR 1
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S295
EP S295
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600295
ER
PT J
AU Pandey, MK
Belanger, AP
Bhattacharyya, F
Wang, SY
DeGrado, TR
AF Pandey, Mukesh K.
Belanger, Anthony P.
Bhattacharyya, Falguni
Wang, Shuyan
DeGrado, Timothy R.
TI Radiotracer Evaluation of Fatty Acid Oxidation (FAO) in Skeletal Muscle
in Rats: Effects of Muscle Stimulation and Acute CPT-1 Inhibition
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Pandey, Mukesh K.; Belanger, Anthony P.; Wang, Shuyan; DeGrado, Timothy R.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Pandey, Mukesh K.; Belanger, Anthony P.; Wang, Shuyan; DeGrado, Timothy R.] Harvard Univ, Sch Med, Boston, MA USA.
[Bhattacharyya, Falguni] NIH, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S146
EP S146
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600147
ER
PT J
AU Reid, AE
Kim, SW
Seinner, B
Hooker, J
Ferrieri, R
Babst, B
Fowler, JS
AF Reid, Alicia E.
Kim, Sung Won
Seinner, Brienne
Hooker, Jacob
Ferrieri, Richard
Babst, Benjamin
Fowler, Joanna S.
TI C-11 labeling of the auxin (3-indolyl[1-C-11]acetic acid) and its
derivatives from gramine for PET imaging of transport and signaling in
plants
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
C1 [Reid, Alicia E.] CUNY Medgar Evers Coll, Brooklyn, NY 11973 USA.
[Kim, Sung Won] NIAAA, Bethesda, MD USA.
[Seinner, Brienne] U Missouri, Columbia, MO USA.
[Hooker, Jacob] Martinos Ctr, Boston, MA USA.
[Ferrieri, Richard; Babst, Benjamin; Fowler, Joanna S.] Brookhaven Natl Lab, Upton, NY USA.
NR 3
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S25
EP S25
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600026
ER
PT J
AU Seo, YJ
Lisa, M
Kang, Y
Kim, SW
Hooker, J
Reid, AE
Haggarty, S
Volkow, N
Fowler, JS
AF Seo, Young Jun
Lisa, Muench
Kang, Yeona
Kim, Sung Won
Hooker, Jacob
Reid, Alicia E.
Haggarty, Stephen
Volkow, Nora
Fowler, Joanna S.
TI The rational design and development of C-11 labeled PET radiotracers for
histone deacetylase in the central nervous system
SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
LA English
DT Meeting Abstract
ID BRAIN
C1 [Seo, Young Jun; Kang, Yeona; Fowler, Joanna S.] Brookhaven Natl Lab, Upton, NY 11973 USA.
[Lisa, Muench; Kim, Sung Won; Volkow, Nora] NIAAA, Bethesda, MD USA.
[Hooker, Jacob] Martinos Ctr, Boston, MA USA.
[Reid, Alicia E.] CUNY Medgar Evers Coll, Brooklyn, NY 11225 USA.
[Haggarty, Stephen] Harvard Univ, Sch Med, Boston, MA USA.
[Volkow, Nora] NIDA, Bethesda, MD 20892 USA.
NR 3
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0362-4803
J9 J LABELLED COMPD RAD
JI J. Label. Compd. Radiopharm.
PY 2011
VL 54
SU 1
BP S315
EP S315
PG 1
WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry,
Analytical
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 833RC
UT WOS:000295901600315
ER
PT J
AU Li, K
Zhang, HW
Xie, HC
Liang, Y
Wang, XH
Ito, Y
AF Li, Kang
Zhang, Hongwu
Xie, Huichun
Liang, Yong
Wang, Xiaohong
Ito, Yoichiro
TI PREPARATIVE ISOLATION AND PURIFICATION OF FIVE FLAVONOIDS FROM
POGOSTEMON CABLIN BENTH BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY AND
PREPARATIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE flavones; flavanones; flavonoid; high-speed countercurrent
chromatography; pogostemon cablin (Blanco) Benth; preparative HPLC;
two-phase solvent system
AB High-speed countercurrent chromatography (HSCCC) and preparative high-performance liquid chromatography (prep-HPLC) were successively used for the separation of pogostone and four flavonoids from Pogostemon cablin (Blanco) Benth. An efficient HSCCC separation was achieved on a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (11: 5: 11: 5, v/v/v/v). Three well-separated peaks were obtained in the HSCCC chromatogram. The first and the second fractions each contained two flavonoids that were further separated by preparative HPLC. Consequently, the separation yielded 11.5 mg of 4',5-Dihydroxy-3',7-dimethoxyflavanone at a purity of 99%, 20.3 mg of 5-Hydroxy-7,3',4'-trimethoxyflavanone at a purity of 98%, 18 mg of 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone at a purity of 96%, and 8 mg of 5-Hydroxy-3,7,4'-tetramethoxyflavone at a purity of 98%. The third HSCCC fraction yielded 18.5 mg of pogostone at a purity of 95%. The chemical structures of these compounds were identified by ESI-MSn, H-1-NMR, and C-13-NMR.
C1 [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
[Li, Kang; Zhang, Hongwu] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China.
[Xie, Huichun; Liang, Yong; Wang, Xiaohong] S China Normal Univ, Sch Chem & Environm, Guangzhou, Guangdong, Peoples R China.
RP Ito, Y (reprint author), NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bldg 10,Room 8N230,10 Ctr Dr, Bethesda, MD 20892 USA.
EM itoy2@mail.nih.gov
FU National Natural Science Foundation for Young Scholars of China
[30801515]
FX This work was supported by the National Natural Science Foundation for
Young Scholars of China (Grant No. 30801515).
NR 15
TC 7
Z9 8
U1 2
U2 20
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1082-6076
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PY 2011
VL 34
IS 15
BP 1617
EP 1629
DI 10.1080/10826076.2011.580486
PG 13
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 837UV
UT WOS:000296231000012
PM 21949473
ER
PT J
AU Kish, LB
Khatri, SP
Bezrukov, SM
Peper, F
Gingl, Z
Horvath, T
AF Kish, Laszlo B.
Khatri, Sunil P.
Bezrukov, Sergey M.
Peper, Ferdinand
Gingl, Zoltan
Horvath, Tamas
TI Noise-based Deterministic Logic and Computing: a Brief Survey
SO INTERNATIONAL JOURNAL OF UNCONVENTIONAL COMPUTING
LA English
DT Article; Proceedings Paper
CT 4th International Workshop on Natural Computing (IWNC)
CY SEP 23-25, 2009
CL Himeji Int Exchange Ctr, Himeji, JAPAN
SP Natl Inst Informat & Commun Technol (NICT), Osaka Elect Commun Univ (OECU), Univ Hyogo (UH), Himeji City, Support Ctr Adv Telecommunicat Technol Res, Soc Instrument & Control Engn
HO Himeji Int Exchange Ctr
DE Noise-based computing; Logic circuits; Error rate; Energy efficiency;
Noise in Brain
ID ENERGY; SUPERPOSITION; SPIKES; STATES
AB A short survey is provided about our recent explorations of the young topic of noise-based logic. After outlining the motivation behind noise-based computation schemes, we present a short summary of our ongoing efforts in the introduction, development and design of several noise-based deterministic multivalued logic schemes and elements. In particular, we describe classical, instantaneous, continuum, spike and random-telegraph-signal based schemes with applications such as circuits that emulate the brain's functioning and string verification via a slow communication channel.
C1 [Kish, Laszlo B.; Khatri, Sunil P.] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
[Bezrukov, Sergey M.] NICHD, Lab Phys & Struct Biol, Program Phys Biol, NIH, Bethesda, MD 20892 USA.
[Peper, Ferdinand] Natl Inst Informat & Commun Technol, Kobe, Hyogo 6512492, Japan.
[Gingl, Zoltan] Univ Szeged, Dept Tech Informat, H-6720 Szeged, Hungary.
[Horvath, Tamas] Univ Bonn, Dept Comp Sci, D-5300 Bonn, Germany.
[Horvath, Tamas] Schloss Birlinghoven, Fraunhofer IAIS, D-53754 St Augustin, Germany.
RP Kish, LB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
EM Laszlo.Kish@ece.tamu.edu
RI Gingl, Zoltan/E-8262-2011
OI Gingl, Zoltan/0000-0001-6570-2685
NR 20
TC 0
Z9 0
U1 1
U2 3
PU OLD CITY PUBLISHING INC
PI PHILADELPHIA
PA 628 NORTH 2ND ST, PHILADELPHIA, PA 19123 USA
SN 1548-7199
J9 INT J UNCONV COMPUT
JI Int. J. Unconv. Comput.
PY 2011
VL 7
IS 1-2
SI SI
BP 101
EP 113
PG 13
WC Computer Science, Theory & Methods
SC Computer Science
GA 835ZE
UT WOS:000296075000008
ER
PT J
AU Olivier, KN
AF Olivier, Kenneth N.
TI NEW THOUGHTS ABOUT NONTUBERCULOUS MYCOBACTERIA INFECTIONS IN CF
SO PEDIATRIC PULMONOLOGY
LA English
DT Meeting Abstract
ID CYSTIC-FIBROSIS; PREVALENCE; DISEASE; FEATURES
C1 [Olivier, Kenneth N.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 8755-6863
EI 1099-0496
J9 PEDIATR PULM
JI Pediatr. Pulmonol.
PY 2011
SU 34
BP 209
EP 211
PG 3
WC Pediatrics; Respiratory System
SC Pediatrics; Respiratory System
GA 835YA
UT WOS:000296071800079
ER
PT S
AU Ghosh, P
Antani, S
Long, LR
Thoma, GR
AF Ghosh, Payel
Antani, Sameer
Long, L. Rodney
Thoma, George R.
BE Olive, M
Solomonides, T
TI Review of Medical Image Retrieval Systems and Future Directions
SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS
(CBMS)
SE IEEE International Symposium on Computer-Based Medical Systems
LA English
DT Proceedings Paper
CT 24th International Symposium on Computer-Based Medical Systems (CBMS)
CY JUN 27-30, 2011
CL Univ W England, Bristol, ENGLAND
SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP
HO Univ W England
ID SEARCH; ENGINE
AB This paper presents a review of online systems for content-based medical image retrieval (CBIR). The objective of this review is to evaluate the capabilities and gaps in these systems and to determine ways of improving relevance of multi-modal (text and image) information retrieval in the iMedline system, being developed at the National Library of Medicine (NLM). Seven medical information retrieval systems: Figuresearch, BioText, GoldMiner, Yale Image Finder, Yottalook, Image Retrieval for Medical Applications (IRMA), and iMedline have been evaluated here using the system of gaps defined in [1]. Not all of these systems take advantage of the visual information contained in biomedical literature as figures and illustrations. However, all attempt to extract metadata about the image from the full-text of the articles and retrieve figures/images in response to a query. iMedline aims to advance the state-of-the-art in multimodal information retrieval by unifying image and text features in computing relevance. We discuss the shortcomings of these current systems and discuss future directions and next steps in iMedline toward context-based medical image retrieval.
C1 [Ghosh, Payel; Antani, Sameer; Long, L. Rodney; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20852 USA.
RP Ghosh, P (reprint author), NIH, US Natl Lib Med, Bethesda, MD 20852 USA.
EM ghoshp3@mail.nih.gov; santani@mail.nih.gov; rlong@mail.nih.gov;
gthoma@mail.nih.gov
NR 9
TC 0
Z9 0
U1 0
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1063-7125
BN 978-1-4577-1190-9
J9 COMP MED SY
PY 2011
PG 6
WC Computer Science, Information Systems; Computer Science,
Interdisciplinary Applications
SC Computer Science
GA BWZ98
UT WOS:000295472700058
ER
PT S
AU Rahman, MM
Antani, SK
Thoma, GR
AF Rahman, Md Mahmudur
Antani, Sameer K.
Thoma, George R.
BE Olive, M
Solomonides, T
TI Biomedical CBIR using "Bag of Keypoints" in a Modified Inverted Index
SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS
(CBMS)
SE IEEE International Symposium on Computer-Based Medical Systems
LA English
DT Proceedings Paper
CT 24th International Symposium on Computer-Based Medical Systems (CBMS)
CY JUN 27-30, 2011
CL Univ W England, Bristol, ENGLAND
SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP
HO Univ W England
ID FEATURES
AB This paper presents a "bag of keypoints" based medical image retrieval approach to cope with a large variety of visually different instances under the same category or modality. Keypoint similarities in the codebook are computed using a quadratic similarity measure. The codebook is implemented using a topology preserving Self Organizing Map (SOM) which represents images as sparse feature vectors and an inverted index is created on top of this to facilitate efficient retrieval. In addition, to increase the retrieval effectiveness, query expansion is performed by exploiting the similarities between the keypoints based on analyzing the local neighborhood structure of the SOM generated codebook. The search is thus query-specific and restricted to a sub-space spanned only by the original and expanded keypoints of the query images. A systematic evaluation of retrieval results on a biomedical image collection of 5000 biomedical images of different modalities, body parts, and orientations shows a halving in computation time (efficiency) and 10% to 15% improvement in precision at each recall level (effectiveness) when compared to individual color, texture, edge-related features.
C1 [Rahman, Md Mahmudur; Antani, Sameer K.; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA.
RP Rahman, MM (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1063-7125
BN 978-1-4577-1190-9
J9 COMP MED SY
PY 2011
PG 6
WC Computer Science, Information Systems; Computer Science,
Interdisciplinary Applications
SC Computer Science
GA BWZ98
UT WOS:000295472700052
ER
PT S
AU Xue, ZY
Long, LR
Antani, S
Thoma, GR
AF Xue, Zhiyun
Long, L. Rodney
Antani, Sameer
Thoma, George R.
BE Olive, M
Solomonides, T
TI Spine x-ray image retrieval using partial vertebral boundaries
SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS
(CBMS)
SE IEEE International Symposium on Computer-Based Medical Systems
LA English
DT Proceedings Paper
CT 24th International Symposium on Computer-Based Medical Systems (CBMS)
CY JUN 27-30, 2011
CL Univ W England, Bristol, ENGLAND
SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP
HO Univ W England
AB The anterior osteophyte (AO) is a bony spur on the vertebra and is symptomatic of osteo-arthritis of the spine. We present advances in our research into matching vertebral boundaries based on pathological (severity) and visual similarity. Proposed image retrieval methods are based on partial shape matching (PSM) that use landmarks along sagittal vertebral outlines that are consistent with those used by medical experts. Besides the two PSM methods that are improved algorithms of our previously developed methods, a new PSM method that is based on a simple but effective localized shape feature is proposed. The methods are evaluated and tested on a dataset of 856 segmented vertebrae and their performance is compared using precision-recall and average precision graphs. The best approaches are combined and integrated into our Web-based Spine Pathology & Image Retrieval System (SPIRS).
C1 [Xue, Zhiyun; Long, L. Rodney; Antani, Sameer; Thoma, George R.] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
RP Xue, ZY (reprint author), NIH, Natl Lib Med, Bethesda, MD 20892 USA.
EM xuez@mail.nih.gov; rlong@mail.nih.gov; santani@mail.nih.gov;
gthoma@mail.nih.gov
NR 8
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1063-7125
BN 978-1-4577-1190-9
J9 COMP MED SY
PY 2011
PG 6
WC Computer Science, Information Systems; Computer Science,
Interdisciplinary Applications
SC Computer Science
GA BWZ98
UT WOS:000295472700062
ER
PT J
AU Baker, SG
Lindeman, KS
Kramer, BS
AF Baker, Stuart G.
Lindeman, Karen S.
Kramer, Barnett S.
TI Clarifying the Role of Principal Stratification in the Paired
Availability Design
SO INTERNATIONAL JOURNAL OF BIOSTATISTICS
LA English
DT Article
DE principal stratification; causal inference; paired availability design
ID EPIDURAL ANALGESIA; IDENTIFICATION; STATISTICS; INFERENCE; TRIALS
AB The paired availability design for historical controls postulated four classes corresponding to the treatment (old or new) a participant would receive if arrival occurred during either of two time periods associated with different availabilities of treatment. These classes were later extended to other settings and called principal strata. Judea Pearl asks if principal stratification is a goal or a tool and lists four interpretations of principal stratification. In the case of the paired availability design, principal stratification is a tool that falls squarely into Pearl's interpretation of principal stratification as "an approximation to research questions concerning population averages." We describe the paired availability design and the important role played by principal stratification in estimating the effect of receipt of treatment in a population using data on changes in availability of treatment. We discuss the assumptions and their plausibility. We also introduce the extrapolated estimate to make the generalizability assumption more plausible. By showing why the assumptions are plausible we show why the paired availability design, which includes principal stratification as a key component, is useful for estimating the effect of receipt of treatment in a population. Thus, for our application, we answer Pearl's challenge to clearly demonstrate the value of principal stratification.
C1 [Baker, Stuart G.; Kramer, Barnett S.] Natl Inst Hlth, Bethesda, MD 20892 USA.
[Lindeman, Karen S.] Johns Hopkins Med Inst, Baltimore, MD USA.
RP Baker, SG (reprint author), Natl Inst Hlth, Bethesda, MD 20892 USA.
NR 16
TC 2
Z9 2
U1 0
U2 0
PU BERKELEY ELECTRONIC PRESS
PI BERKELEY
PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA
SN 1557-4679
J9 INT J BIOSTAT
JI Int. J. Biostat.
PY 2011
VL 7
IS 1
AR 25
DI 10.2202/1557-4679.1338
PG 12
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA 832FX
UT WOS:000295789600025
PM 21686085
ER
PT J
AU Kukush, A
Shklyar, S
Masiuk, S
Likhtarov, I
Kovgan, L
Carroll, RJ
Bouville, A
AF Kukush, Alexander
Shklyar, Sergiy
Masiuk, Sergii
Likhtarov, Illya
Kovgan, Lina
Carroll, Raymond J.
Bouville, Andre
TI Methods for Estimation of Radiation Risk in Epidemiological Studies
Accounting for Classical and Berkson Errors in Doses
SO INTERNATIONAL JOURNAL OF BIOSTATISTICS
LA English
DT Article
DE Berkson measurement error; Chornobyl accident; classical measurement
error; estimation of radiation risk; full maximum likelihood estimating
procedure; regression calibration; SIMEX estimator; uncertainties in
thyroid dose
ID CHERNOBYL THYROID CANCERS; QUASI-SCORE ESTIMATOR; NEVADA TEST-SITE;
UNCERTAINTY ANALYSIS; UKRAINE; ACCIDENT; MODELS; DOSIMETRY; FALLOUT
AB With a binary response Y, the dose-response model under consideration is logistic in flavor with pr(Y=1 vertical bar D) = R (1+R)(-1), R =lambda(0) + EAR D, where lambda(0) is the baseline incidence rate and EAR is the excess absolute risk per gray. The calculated thyroid dose of a person i is expressed as D(i)(mes) = f(i)Q(i)(mes)/M(i)(mes). Here, Q(i)(mes) is the measured content of radioiodine in the thyroid gland of person i at time t(mes), M(i)(mes) is the estimate of the thyroid mass, and f(i) is the normalizing multiplier. The Q(i) and M(i) are measured with multiplicative errors V(i)(Q) and V(i)(M), so that Q(i)(mes) = Q(i)(tr)V(i)(Q) (this is classical measurement error model) and M(i)(tr) = M(i)(mes)V(i)(M) (this is Berkson measurement error model). Here, Q(i)(tr) is the true content of radioactivity in the thyroid gland, and M(i)(tr) is the true value of the thyroid mass. The error in f(i) is much smaller than the errors in (Q(i)(mes), M(i)(mes)) and ignored in the analysis.
By means of Parametric Full Maximum Likelihood and Regression Calibration (under the assumption that the data set of true doses has lognormal distribution), Nonparametric Full Maximum Likelihood, Nonparametric Regression Calibration, and by properly tuned SIMEX method we study the influence of measurement errors in thyroid dose on the estimates of lambda(0) and EAR. The simulation study is presented based on a real sample from the epidemiological studies. The doses were reconstructed in the framework of the Ukrainian-American project on the investigation of Post-Chernobyl thyroid cancers in Ukraine, and the underlying subpolulation was artificially enlarged in order to increase the statistical power. The true risk parameters were given by the values to earlier epidemiological studies, and then the binary response was simulated according to the dose-response model.
C1 [Carroll, Raymond J.] Texas A&M Univ, College Stn, TX 77843 USA.
[Bouville, Andre] NCI, NIH, DHHS, Bethesda, MD 20892 USA.
FU U.S. National Cancer Institute; Radiation Protection Institute ATS of
Ukraine; Swedish Institute [SI-01424/2007]; National Cancer Institute
[CA57030]; King Abdullah University of Science and Technology (KAUST)
[KUSCI-016-04]
FX This work was supported by funds from the U.S. National Cancer Institute
and the Radiation Protection Institute ATS of Ukraine. The authors also
want to thank their colleges from the Institute of Endocrinology and
Metabolism AMS of Ukraine and the Radiation Protection Institute ATS of
Ukraine who contributed to the preparation of the results presented in
the paper. Alexander Kukush is supported by the Swedish Institute grant
SI-01424/2007. Carroll's research was supported by a grant from the
National Cancer Institute (CA57030). This publication is based in part
on work supported by Award Number KUSCI-016-04, made by King Abdullah
University of Science and Technology (KAUST).
NR 30
TC 6
Z9 6
U1 1
U2 5
PU BERKELEY ELECTRONIC PRESS
PI BERKELEY
PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA
SN 1557-4679
J9 INT J BIOSTAT
JI Int. J. Biostat.
PY 2011
VL 7
IS 1
AR 15
DI 10.2202/1557-4679.1281
PG 31
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA 832FX
UT WOS:000295789600015
PM 21423564
ER
PT J
AU Moye, LA
Lai, DJ
Jing, KY
Baraniuk, MS
Kwak, M
Penn, MS
Wu, CO
AF Moye, Lemuel A.
Lai, Dejian
Jing, Kaiyan
Baraniuk, Mary Sarah
Kwak, Minjung
Penn, Marc S.
Wu, Colon O.
TI Combining Censored and Uncensored Data in a U-Statistic: Design and
Sample Size Implications for Cell Therapy Research
SO INTERNATIONAL JOURNAL OF BIOSTATISTICS
LA English
DT Article
DE U-statistic; clinical trials; score function; stem cells
ID ACUTE MYOCARDIAL-INFARCTION; MULTIPLE END-POINTS; VENTRICULAR
ENLARGEMENT TRIAL; SEQUENTIAL CLINICAL-TRIALS; HEMATOPOIETIC STEM-CELLS;
BONE-MARROW-CELLS; HEART-FAILURE; INTRACORONARY INJECTION;
ISCHEMIC-MYOCARDIUM; MONONUCLEAR-CELLS
AB The assumptions that anchor large clinical trials are rooted in smaller, Phase II studies. In addition to specifying the target population, intervention delivery, and patient follow-up duration, physician-scientists who design these Phase II studies must select the appropriate response variables (endpoints). However, endpoint measures can be problematic. If the endpoint assesses the change in a continuous measure over time, then the occurrence of an intervening significant clinical event (SCE), such as death, can preclude the follow-up measurement. Finally, the ideal continuous endpoint measurement may be contraindicated in a fraction of the study patients, a change that requires a less precise substitution in this subset of participants.
A score function that is based on the U-statistic can address these issues of 1) intercurrent SCE's and 2) response variable ascertainments that use different measurements of different precision. The scoring statistic is easy to apply, clinically relevant, and provides flexibility for the investigators' prospective design decisions. Sample size and power formulations for this statistic are provided as functions of clinical event rates and effect size estimates that are easy for investigators to identify and discuss. Examples are provided from current cardiovascular cell therapy research.
C1 [Moye, Lemuel A.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA.
[Kwak, Minjung; Wu, Colon O.] NHLBI, Bethesda, MD 20892 USA.
[Penn, Marc S.] Cleveland Clin Fdn, Cleveland, OH USA.
RP Moye, LA (reprint author), Univ Texas Hlth Sci Ctr Houston, Houston, TX USA.
FU NHLBI
FX Three clinical trials in the NHLBI sponsored Cardiovascular Cell Therapy
Research Network (CCTRN) are currently underway in which we will assess
the utility of this approach.
NR 41
TC 1
Z9 1
U1 1
U2 5
PU BERKELEY ELECTRONIC PRESS
PI BERKELEY
PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA
SN 1557-4679
J9 INT J BIOSTAT
JI Int. J. Biostat.
PY 2011
VL 7
IS 1
AR 29
DI 10.2202/1557-4679.1286
PG 30
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA 832FX
UT WOS:000295789600029
ER
PT J
AU Saito, K
Matsumoto, S
Devusahayam, N
Subramanian, S
Munasinghe, J
Patel, V
Gutkind, JS
Mitchell, JB
Cherukuri, MK
AF Saito, Keito
Matsumoto, Shingo
Devusahayam, Nallathamby
Subramanian, Sankaran
Munasinghe, Jeeva
Patel, Vyomesh
Gutkind, J. Silvio
Mitchell, James B.
Cherukuri, Murali Krishna
TI Rapamycin improves tumor oxygenation and vascular renormalization
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Meeting Abstract
C1 [Saito, Keito; Matsumoto, Shingo; Devusahayam, Nallathamby; Subramanian, Sankaran; Mitchell, James B.; Cherukuri, Murali Krishna] NCI, Radiat Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Munasinghe, Jeeva] Natl Inst Neurol Disorder & Stroke, Bethesda, MD 20892 USA.
[Patel, Vyomesh; Gutkind, J. Silvio] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA.
RI Gutkind, J. Silvio/A-1053-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
J9 INT J MOL MED
JI Int. J. Mol. Med.
PY 2011
VL 28
SU 1
MA 375
BP S73
EP S73
PG 1
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 827IR
UT WOS:000295422700277
ER
PT J
AU Mattay, V
AF Mattay, V
TI Imaging Genetic Influences in Normal Cognitive Aging
SO JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
C1 [Mattay, V] NIMH, Genes Cognit & Psychosis Program, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU HOGREFE & HUBER PUBLISHERS
PI GOTTINGEN
PA ROHNSWEG 25, D-37085 GOTTINGEN, GERMANY
SN 0269-8803
J9 J PSYCHOPHYSIOL
JI J. Psychophysiol.
PY 2011
VL 25
SU 1
BP 22
EP 22
PG 1
WC Psychology, Biological; Neurosciences
SC Psychology; Neurosciences & Neurology
GA 832FA
UT WOS:000295786600063
ER
PT J
AU Chrousos, GP
Kino, T
AF Chrousos, G. P.
Kino, T.
TI New Partners of the Glucocorticoid Receptor: Clock and Mutual,
Multi-Level Interactions of the Circadian CLOCK System and the HPA Axis
SO NEUROIMMUNOMODULATION
LA English
DT Meeting Abstract
C1 Univ Athens, Dept Pediat 1, Athens, Greece.
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2011
VL 18
IS 6
BP 368
EP 368
PG 1
WC Endocrinology & Metabolism; Immunology; Neurosciences
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 832FQ
UT WOS:000295788700022
ER
PT J
AU Naude, PJW
Eiden, LE
den Boer, JA
Luiten, PGM
Eisel, ULM
AF Naude, P. J. W.
Eiden, L. E.
den Boer, J. A.
Luiten, P. G. M.
Eisel, U. L. M.
TI A Novel Neuroinflammatory Agent that Silences Tumour Necrosis Factor
Alpha Receptor 2 Mediated Neuroprotection
SO NEUROIMMUNOMODULATION
LA English
DT Meeting Abstract
C1 [Naude, P. J. W.; Luiten, P. G. M.; Eisel, U. L. M.] Univ Groningen, NL-9700 AB Groningen, Netherlands.
[Eiden, L. E.; den Boer, J. A.] NIMH, Mol Neurosci Sect, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2011
VL 18
IS 6
BP 394
EP 394
PG 1
WC Endocrinology & Metabolism; Immunology; Neurosciences
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 832FQ
UT WOS:000295788700095
ER
PT J
AU Silverman, M
Marques, A
Sternberg, EM
AF Silverman, M.
Marques, A.
Sternberg, E. M.
TI Neural Immune Mechanisms in Fatigue
SO NEUROIMMUNOMODULATION
LA English
DT Meeting Abstract
C1 [Silverman, M.; Sternberg, E. M.] NIMH, Sect Neuroendocrine Immunol & Behav, NIH, Bethesda, MD 20892 USA.
[Marques, A.] Columbia Univ, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2011
VL 18
IS 6
BP 405
EP 405
PG 1
WC Endocrinology & Metabolism; Immunology; Neurosciences
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 832FQ
UT WOS:000295788700124
ER
PT J
AU Watson, PH
Ravid, R
Eng, CB
Litton, JE
Vaught, J
Matusan, A
AF Watson, Peter H.
Ravid, Rivka
Eng, Chon Boon
Litton, Jan-Eric
Vaught, Jim
Matusan, Anita
TI What Are the Main Roadblocks to Transnational Biobank Collaboration, and
How Can We Overcome Them?
SO BIOPRESERVATION AND BIOBANKING
LA English
DT Editorial Material
C1 [Watson, Peter H.] BC Canc Agcy, Victoria, BC V8R 6V5, Canada.
[Ravid, Rivka] Royal Dutch Acad Sci, Brain Bank Consultants, Amsterdam, Netherlands.
[Eng, Chon Boon] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, NUHS Tissue Repository & Hosp Based Canc Registry, Singapore 119074, Singapore.
[Litton, Jan-Eric] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Vaught, Jim] NCI, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA.
[Matusan, Anita] Peter MacCallum Canc Ctr, Australasian Biospecimen Network Oncol, Melbourne, Vic 8006, Australia.
RP Watson, PH (reprint author), BC Canc Agcy, 2410 Lee Ave, Victoria, BC V8R 6V5, Canada.
EM pwatson@bccancer.bc.ca; rivkagravid@gmail.com;
Chon_Boon_ENG@NUHS.edu.sg; Jan-Eric.Litton@ki.se; vaughtj@mail.nih.gov
NR 0
TC 7
Z9 7
U1 0
U2 8
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1947-5535
J9 BIOPRESERV BIOBANK
JI Biopreserv. Biobank.
PY 2011
VL 9
IS 3
BP 213
EP 216
DI 10.1089/bio.2011.9340
PG 4
WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology
SC Cell Biology; Chemistry; Medical Laboratory Technology
GA 827ST
UT WOS:000295449200002
PM 24850325
ER
PT J
AU Yu, BB
AF Yu, Binbing
TI Estimating age-specific incidence of dementia using prevalent cohort
data
SO JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
LA English
DT Article
DE dementia incidence; prevalent cohort; penalized likelihood
ID SHORT-TERM PROJECTIONS; JAPANESE-AMERICAN MEN; ALZHEIMERS-DISEASE;
TRUNCATED DATA; MORTALITY; STATIONARITY; INFECTION; MODELS
AB In prospective cohort studies, individuals are usually recruited according to a certain cross-sectional sampling criterion. The prevalent cohort is defined as a group of individuals who are alive but possibly with disease at the beginning of the study. It is appealing to incorporate the prevalent cases to estimate the incidence rate of disease before the enrollment. The method of back calculation of incidence rate has been used to estimate the incubation time from human immunodeficiency virus (HIV) infection to AIDS. The time origin is defined as the time of HIV infection. In aging cohort studies, the primary time scale is age of disease onset, subjects have to survive certain years to be enrolled into the study, thus creating left truncation (delay entry). The current methods usually assume that either the disease incidence is rare or the excess mortality due to disease is small compared with the healthy subjects. So far the validity of the results based on these assumptions has not been examined. In this paper, a simple alternative method is proposed to estimate dementia incidence rate before enrollment using prevalent cohort data with left truncation. Furthermore, simulations are used to examine the performance of the estimation of disease incidence under different assumptions of disease incidence rates and excess mortality hazards due to disease. As application, the method is applied to the prevalent cases of dementia from the Honolulu-Asia Aging Study to estimate the dementia incidence rate and to assess the effect of hypertension, Apoe 4 and education on dementia onset.
C1 NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
RP Yu, BB (reprint author), NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
EM yubi@mail.nih.gov
FU National Institute on Aging under NIH [NIH12710587]
FX The research was supported in part by the Intramural Research Program of
the National Institute on Aging, under the NIH Grant No. NIH12710587.
NR 23
TC 0
Z9 0
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0094-9655
EI 1563-5163
J9 J STAT COMPUT SIM
JI J. Stat. Comput. Simul.
PY 2011
VL 81
IS 8
BP 973
EP 983
DI 10.1080/00949650903583496
PG 11
WC Computer Science, Interdisciplinary Applications; Statistics &
Probability
SC Computer Science; Mathematics
GA 830UP
UT WOS:000295683000004
PM 21860539
ER
PT J
AU Duque, LF
Ungar, M
Caicedo, B
AF Duque, Luis F.
Ungar, Michael
Caicedo, Beatriz
BE Denov, M
Maclure, R
Campbell, K
TI Addressing Youth Violence and Aggression in Colombia: Examining a
Community-Wide Prevention Initiative
SO CHILDREN'S RIGHTS AND INTERNATIONAL DEVELOPMENT: LESSONS AND CHALLENGES
FROM THE FIELD
LA English
DT Article; Book Chapter
ID DEVELOPMENTAL TRAJECTORIES; PHYSICAL AGGRESSION; CONDUCT PROBLEMS;
DELINQUENCY; BEHAVIOR; CHILDREN; BOYS; STABILITY; PATTERNS; FAMILIES
C1 [Duque, Luis F.] Univ Antioquia, Sch Publ Hlth, PREVIVA Program Violence & Risky Conducts Prevent, Medellin, Colombia.
[Duque, Luis F.] Natl Inst Hlth, Hlth Serv Direct, Bethesda, MD USA.
[Duque, Luis F.] World Bank, Washington, DC USA.
[Duque, Luis F.] WHO, New York, NY 10017 USA.
[Ungar, Michael] Dalhousie Univ, Halifax, NS B3H 3J5, Canada.
[Caicedo, Beatriz] Univ Bristol, Bristol BS8 1TH, Avon, England.
RP Duque, LF (reprint author), Harvard Univ, Cambridge, MA 02138 USA.
NR 47
TC 1
Z9 3
U1 0
U2 0
PU PALGRAVE
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND
BN 978-0-23011-925-3
PY 2011
BP 129
EP 151
D2 10.1057/9780230119253
PG 23
WC Social Issues; Social Sciences, Interdisciplinary
SC Social Issues; Social Sciences - Other Topics
GA BWP76
UT WOS:000294449700007
ER
PT J
AU Tanofsky-Kraff, M
Yanovski, SZ
Yanovski, JA
AF Tanofsky-Kraff, Marian
Yanovski, Susan Z.
Yanovski, Jack A.
BE StriegelMoore, RH
Wonderlich, SA
Walsh, BT
Mitchell, JE
TI LOSS OF CONTROL OVER EATING IN CHILDREN AND ADOLESCENTS
SO DEVELOPING AN EVIDENCE-BASED CLASSIFICATION OF EATING DISORDERS:
SCIENTIFIC FINDINGS FOR DSM-5
LA English
DT Article; Book Chapter
ID AGE-OF-ONSET; OVERWEIGHT CHILDREN; CLINICAL-SIGNIFICANCE; DISORDER
EXAMINATION; OBESE INDIVIDUALS; BULIMIC BEHAVIORS; SEEKING TREATMENT;
COMMUNITY SAMPLE; CONTROLLED-TRIAL; ADULT OBESITY
C1 [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
[Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Growth & Obes, Program Dev Endocrinol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD USA.
[Yanovski, Susan Z.] NIDDKD, Off Obes Res, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Yanovski, Susan Z.] NIDDKD, Obes & Eating Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
RP Tanofsky-Kraff, M (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
NR 63
TC 14
Z9 14
U1 1
U2 1
PU AMER PSYCHIATRIC PRESS, INC
PI WASHINGTON
PA 1400 K ST NW, WASHINGTON, DC 20005 USA
BN 978-0-89042-666-1
PY 2011
BP 221
EP 236
PG 16
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA BWM09
UT WOS:000294220100017
ER
PT S
AU Bagci, U
Udupa, JK
Chen, XJ
AF Bagci, Ulas
Udupa, Jayaram K.
Chen, Xinjian
BE Wong, KH
Holmes, DR
TI Intensity Non-standardness Affects Computer Recognition of Anatomical
Structures
SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND
MODELING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Visualization, Image-Guided
Procedures, and Modeling
CY FEB 13-15, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Intensity Standardization; Object Recognition; Model Based Segmentation;
3D Models
ID INHOMOGENEITY CORRECTION; SCALE; STANDARDIZATION
AB Since MR image intensities do not possess a tissue specific numeric meaning, even in images acquired for the same subject, on the same scanner, for the same body region, by using the same pulse sequence, it is important to transform the image scale into a standard intensity scale so that, for the same body region, intensities are similar. The lack of a standard image intensity scale in MRI leads to many difficulties in tissue characterizability, image display, and analysis, including image segmentation and registration. The influence of standardization on these tasks has been documented well; however, how intensity non-standardness may affect the automatic recognition of anatomical structures for image segmentation has not been studied. Motivated from the study that we previously presented in SPIE Medical Imaging Conference 2010,(1, 2) in this study, we analyze the effects of intensity standardization on anatomical object recognition. A set of 31 scenarios of multiple objects from the ankle complex included in the model, plus seven different realistic levels of non-standardness introduced are considered for evaluation. The experimental results imply that, intensity variation among scenes in an ensemble - a particular characteristic of the behavior of non-standardness - degrades object recognition performance.
C1 [Bagci, Ulas; Chen, Xinjian] NIH, Ctr Clin, Bethesda, MD 20814 USA.
RP Bagci, U (reprint author), NIH, Ctr Clin, Off 1C370, Bethesda, MD 20814 USA.
EM ulasbagci@ieee.org
OI Bagci, Ulas/0000-0001-7379-6829
NR 11
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8506-9
J9 PROC SPIE
PY 2011
VL 7964
AR 79642M
DI 10.1117/12.877779
PG 9
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWM23
UT WOS:000294224900088
ER
PT S
AU Kapoor, A
Li, M
Wood, B
AF Kapoor, Ankur
Li, Ming
Wood, Bradford
BE Wong, KH
Holmes, DR
TI Mixed Variable Optimization for Radio Frequency Ablation Planning
SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND
MODELING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Visualization, Image-Guided
Procedures, and Modeling
CY FEB 13-15, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Optimization; RFA Planning; Mixed Variable
ID OF-THE-ART; FEASIBILITY; ASSISTANCE; ROBOT; MR
AB We present a method towards optimization of multiple ablation probe placement to provide efficient coverage of a tumor for thermal therapy while respecting clinical needs such as limiting the sites of probe insertions at the pleura/liver surface, choosing secure probe trajectories and locations, avoiding ablation of critical structures, reducing ablation of healthy tissue and overlap of ablation zones. The ablation optimizer treats each ablation location independently, and the number of ablation probe placements itself is treated as a variable to be optimized. This allows us to potentially feedback the ablation after deployment and re-optimize the next steps during the plan. The optimization method uses a new class of derivate-free algorithms for solving a non-linear mixed variable problem with hard and soft constraints derived from clinical images. Our methods use discretization of the ablation volume, which can accommodate irregular shape of the ablation zone. The non-gradient based strategy produce new candidates to yield a feasible solution within a few iterations. In our simulation experiments this strategy typically reduced the ablation zone overlap and ablated healthy tissue ablated by 46% and 29%, respectively in a single iteration, resulting in a feasible solution to be found within 35 iterations. Our method for optimization provides efficient implementation for planning the coverage of a tumor while respecting clinical constraints. The ablation planning can be combined with navigation assistance to enable accurate translation and feedback of the plan.
C1 [Kapoor, Ankur; Wood, Bradford] NIH, Ctr Clin, Bethesda, MD 20892 USA.
RP Kapoor, A (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA.
NR 16
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8506-9
J9 PROC SPIE
PY 2011
VL 7964
AR 796420
DI 10.1117/12.876499
PG 7
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWM23
UT WOS:000294224900067
ER
PT S
AU Mann, D
Caban, JJ
Stolka, PJ
Boctor, EM
Yoo, TS
AF Mann, David
Caban, Jesus J.
Stolka, Phillip J.
Boctor, Emad M.
Yoo, Terry S.
BE Wong, KH
Holmes, DR
TI Multi-Dimensional Transfer Functions for Effective Visualization of
Streaming Ultrasound and Elasticity Images
SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND
MODELING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Visualization, Image-Guided
Procedures, and Modeling
CY FEB 13-15, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Visualization; Ultrasound; Elasticity Imaging
AB The low-cost and minimum health risks associated with ultrasound (US) have made ultrasonic imaging a widely accepted method to perform diagnostic and image-guided procedures. Despite the existence of 3D ultrasound probes, most analysis and diagnostic procedures are done by studying the B-mode images. Currently, multiple ultrasound probes include 6-DOF sensors that can provide positioning information. Such tracking information can be used to reconstruct a 3D volume from a set of 2D US images. Recent advances in ultrasound imaging have also shown that, directly from the streaming radio frequency (RF) data, it is possible to obtain additional information of the anatomical region under consideration including the elasticity properties.
This paper presents a generic framework that takes advantage of current graphics hardware to create a low-latency system to visualize streaming US data while combining multiple tissue attributes into a single illustration. In particular, we introduce a framework that enables real-time reconstruction and interactive visualization of streaming data while enhancing the illustration with elasticity information. The visualization module uses two-dimensional transfer functions (2D TFs) to more effectively fuse and map B-mode and strain values into specific opacity and color values. On commodity hardware, our framework can simultaneously reconstruct, render, and provide user interaction at over 15 fps. Results with phantom and real-world medical datasets show the advantages and effectiveness of our technique with ultrasound data. In particular, our results show how two-dimensional transfer functions can be used to more effectively identify, analyze and visualize lesions in ultrasound images.
C1 [Mann, David; Caban, Jesus J.; Yoo, Terry S.] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
RP Mann, D (reprint author), NIH, Natl Lib Med, Bethesda, MD 20892 USA.
RI Boctor, Emad/I-6597-2012
NR 9
TC 1
Z9 1
U1 1
U2 4
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8506-9
J9 PROC SPIE
PY 2011
VL 7964
AR 796439
DI 10.1117/12.878935
PG 10
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWM23
UT WOS:000294224900110
ER
PT S
AU Blum, A
AF Blum, Alan
BE Connolly, T
TI LIFE, DEATH AND THE IN-BETWEEN: THE DUCK-RABBIT/THE FACE OF THE CLOWN
SO SPECTACULAR DEATH: INTERDISCIPLINARY PERSPECTIVES ON MORTALITY AND
(UN)REPRESENTABILITY
SE Culture Disease and Well-Being
LA English
DT Article; Book Chapter
C1 [Blum, Alan] Harvard Univ, Sch Med, NIMH, Cambridge, MA 02138 USA.
[Blum, Alan] Univ Cambridge, Univ London Kings Coll, Amer Council Learned Soc, Cambridge CB2 1TN, England.
[Blum, Alan] Univ Chicago, Jury Project, Chicago, IL 60637 USA.
[Blum, Alan] Roosevelt Hosp, Res Program Sociol Hlth & Illness, New York, NY USA.
[Blum, Alan] Columbia Univ, New York, NY 10027 USA.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU INTELLECT LTD
PI OXFORD
PA KENNETT HOUSE, SUITE 2 108/110 LONDON RD, OXFORD OX3 9AW, ENGLAND
SN 2042-1788
BN 978-1-84150-322-6
J9 CULT DIS WELL BEING
PY 2011
BP 21
EP 41
PG 21
WC History & Philosophy Of Science; Philosophy
SC History & Philosophy of Science; Philosophy
GA BVR73
UT WOS:000292594500002
ER
PT J
AU Choibamroong, T
AF Choibamroong, Therdchai (Ted)
BE Laws, E
Richins, H
Agrusa, J
Scott, N
TI A Stakeholder Approach for Sustainable Community-based Rural Tourism
Development in Thailand
SO TOURIST DESTINATION GOVERNANCE: PRACTICE, THEORY AND ISSUES
LA English
DT Article; Book Chapter
C1 NIDA, NIDA Ctr Integrated Tourism Management Studies NI, Bangkok 10240, Thailand.
RP Choibamroong, T (reprint author), NIDA, NIDA Ctr Integrated Tourism Management Studies NI, 118 Moo3,Sereethai Rd, Bangkok 10240, Thailand.
EM tedchoibamroong@hotmail.com
NR 25
TC 0
Z9 0
U1 0
U2 0
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-84593-794-2
PY 2011
BP 173
EP 186
D2 10.1079/9781845937942.0000
PG 14
WC Hospitality, Leisure, Sport & Tourism
SC Social Sciences - Other Topics
GA BWN24
UT WOS:000294281000015
ER
PT B
AU Vogler, JA
Jackson, W
Nesti, LJ
AF Vogler, Jared A.
Jackson, Wesley
Nesti, Leon J.
BE Owens, BD
Belmont, PJ
TI TISSUE ENGINEERING AND REGENERATION
SO COMBAT ORTHOPEDIC SURGERY: LESSONS LEARNED IN IRAQ AND AFGHANISTAN
LA English
DT Article; Book Chapter
ID PLATELET-RICH PLASMA; GROWTH-FACTOR-BETA; MESENCHYMAL PROGENITOR CELLS;
ORTHOPEDIC-SURGERY; STEM-CELLS; IN-VITRO; NANOFIBROUS SCAFFOLD; GENE
FAMILY; BONE; LIGAMENT
C1 [Vogler, Jared A.; Jackson, Wesley] Walter Reed Natl Mil Med Ctr, Washington, DC USA.
[Vogler, Jared A.; Jackson, Wesley] NIAMSD, Clin & Expt Orthopaed Grp, NIH, Bethesda, MD 20892 USA.
[Jackson, Wesley] McDonald Army Hlth Ctr, Orthopaed Surg Serv, Ft Eustis, VA USA.
RP Vogler, JA (reprint author), Walter Reed Natl Mil Med Ctr, Washington, DC USA.
NR 58
TC 0
Z9 0
U1 0
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA
BN 978-1-55642-965-1
PY 2011
BP 101
EP 108
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA BTZ12
UT WOS:000288484200012
ER
PT B
AU White, SS
Fenton, SE
Yang, CF
Haslam, SZ
AF White, Sally S.
Fenton, Suzanne E.
Yang, Chengfeng
Haslam, Sandra Z.
BE Russo, J
TI Mammary Gland as a Sensitive Tissue to Developmental Exposures of
Perfluorooctanoic Acid (PFOA) in the Mouse
SO ENVIRONMENT AND BREAST CANCER
LA English
DT Article; Book Chapter
DE PFOA; Exposure; Health effects; Mice; Mammary gland; In utero;
Lactation; Peripuberty; Endocrine disruptor
ID RESTRICTED GESTATIONAL EXPOSURES; ACTIVATED RECEPTOR-ALPHA;
PERFLUORINATED CHEMICALS; AMMONIUM PERFLUOROOCTANOATE; PERFLUOROALKYL
COMPOUNDS; SERUM CONCENTRATIONS; COMMUNITY EXPOSURE; CARBOXYLIC-ACIDS;
SULFONATE PFOS; LIVER-ENZYMES
AB The persistence in the environment, combined with the ubiquity of perfluorinated products in the marketplace, has caused what is now recognized as the widespread contamination of human and wildlife tissues with perfluorooctanoic acid (PFOA). The global presence of PFOA has raised concern about adverse health effects that may result from unavoidable human exposures. In this review, we cover the sources of PFOA, its prevalence, and current knowledge about human PFOA exposures and associated health consequences. Examined in detail are PFOA-induced effects on mammary gland in animals. Studies of other environmental agents indicate that late fetal and early postnatal mammary gland development is particularly sensitive to environmental insult. Early life exposures that alter mammary gland development are thought to have a potential impact on the development of mammary cancers later in life in animal models. This is also thought to be the case in humans. Recent research in the mouse examining the effects of in utero, lactational and peripubertal exposures, impact of genetic background, and putative mechanisms of action has made substantial discoveries regarding the effects of PFOA exposure on the mammary gland with high relevancy to human health.
C1 [Yang, Chengfeng; Haslam, Sandra Z.] Michigan State Univ, Dept Biomed & Integrat Physiol, E Lansing, MI 48824 USA.
[Yang, Chengfeng; Haslam, Sandra Z.] Michigan State Univ, Breast Canc & Environm Res Ctr, E Lansing, MI 48824 USA.
[White, Sally S.; Fenton, Suzanne E.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[Yang, Chengfeng] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
RP Haslam, SZ (reprint author), Michigan State Univ, Dept Biomed & Integrat Physiol, E Lansing, MI 48824 USA.
EM suzanne.fenton@nih.gov; shaslam@msu.edu
NR 77
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-9895-8
PY 2011
BP 147
EP 166
DI 10.1007/978-1-4419-9896-5_8
D2 10.1007/978-1-4419-9896-5
PG 20
WC Oncology; Environmental Sciences
SC Oncology; Environmental Sciences & Ecology
GA BWO10
UT WOS:000294369200008
ER
PT B
AU Rayner, JL
Fenton, SE
AF Rayner, Jennifer L.
Fenton, Suzanne E.
BE Russo, J
TI Atrazine: An Environmental Endocrine Disruptor That Alters Mammary Gland
Development and Tumor Susceptibility
SO ENVIRONMENT AND BREAST CANCER
LA English
DT Article; Book Chapter
DE Atrazine; HPG axis; Endocrine disruptor; Herbicide; Mammary gland;
Lactation; Tumor development
ID SPRAGUE-DAWLEY RATS; LONG-EVANS RATS; PRENATAL EXPOSURE;
OVARIAN-FUNCTION; CANCER INCIDENCE; BREAST-CANCER; FEMALE RATS; WISTAR
RAT; METABOLITES; GROWTH
AB Atrazine, a widely used chlorotriazine herbicide, has been regulated and reviewed because of its ability to alter endocrine signaling and cause mammary tumors in female Sprague-Dawley rats. The ability of atrazine to cause breast cancer in humans has been studied and the results are equivocal. Rodent studies showed that atrazine alters the developing mammary gland, makes it susceptible to tumorigenesis or hyperplasia, alters lactational ability, and decreases weight gain in second-generation litters. This chapter reviews the proposed mode of action for mammary tumorigenesis in rodents, results of human studies, and potential modes of action for atrazine effects on the developing mammary gland.
C1 [Fenton, Suzanne E.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[Rayner, Jennifer L.] Oak Ridge Natl Lab, Toxicol & Hazard Assessment Grp, Oak Ridge, TN USA.
RP Fenton, SE (reprint author), NIEHS, Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA.
EM suzanne.fenton@nih.gov
NR 62
TC 5
Z9 5
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-9895-8
PY 2011
BP 167
EP 183
DI 10.1007/978-1-4419-9896-5_9
D2 10.1007/978-1-4419-9896-5
PG 17
WC Oncology; Environmental Sciences
SC Oncology; Environmental Sciences & Ecology
GA BWO10
UT WOS:000294369200009
ER
PT J
AU Johnson, RA
Beck, AM
McCune, S
Griffin, JA
Esposito, L
AF Johnson, Rebecca A.
Beck, Alan M.
McCune, Sandra
Griffin, James A.
Esposito, Layla
BA Johnson, RA
Beck, AM
McCune, S
BF Johnson, RA
Beck, AM
McCune, S
TI Future directions in dog walking
SO HEALTH BENEFITS OF DOG WALKING FOR PEOPLE AND PETS: EVIDENCE AND CASE
STUDIES
SE New Directions in the Human-Animal Bond
LA English
DT Article; Book Chapter
ID PHYSICAL-ACTIVITY; CHILDREN; OBESITY; PREVENTION; THERAPY; GROWTH;
HEALTH; BITES
C1 [Johnson, Rebecca A.] Univ Missouri, Coll Vet Med, Sinclair Sch Nursing, Columbia, MO 65211 USA.
[Johnson, Rebecca A.] Univ Missouri, Coll Vet Med, Res Ctr Human Anim Interact, Columbia, MO USA.
[Griffin, James A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Child Dev & Behav Branch, Ctr Res Mothers & Children, NIH, Rockville, MD USA.
[Beck, Alan M.] Purdue Univ, Sch Vet Med, W Lafayette, IN 47907 USA.
RP Johnson, RA (reprint author), Univ Missouri, Coll Vet Med, Sinclair Sch Nursing, Columbia, MO 65211 USA.
NR 35
TC 0
Z9 0
U1 1
U2 4
PU PURDUE UNIV PRESS
PI W LAFAYETTE
PA SOUTH CAMPUS COURTS D, W LAFAYETTE, IN 47907 USA
BN 978-1-55753-582-5
J9 NEW DIR HUM-ANIM BON
PY 2011
BP 181
EP 191
PG 11
WC Public, Environmental & Occupational Health; Veterinary Sciences
SC Public, Environmental & Occupational Health; Veterinary Sciences
GA BWJ18
UT WOS:000294004000012
ER
PT B
AU Doria-Rose, VP
Szabo, E
AF Doria-Rose, V. Paul
Szabo, Eva
BA Kernstine, KH
Reckamp, KL
BF Kernstine, KH
Reckamp, KL
TI Screening and Prevention of Lung Cancer
SO LUNG CANCER: A MULTIDISCIPLINARY APPROACH TO DIAGNOSIS AND MANAGEMENT
SE Current Multidisciplinary Oncology
LA English
DT Article; Book Chapter
ID LOW-DOSE CT; SPIRAL COMPUTED-TOMOGRAPHY; COST-EFFECTIVENESS ANALYSIS;
GUIDELINES 2ND EDITION; RANDOMIZED CONTROLLED TRIAL; VOLATILE
ORGANIC-COMPOUNDS; NEEDLE ASPIRATION BIOPSY; CARCINOMA IN-SITU;
HIGH-RISK COHORT; CHEST-X-RAY
C1 [Doria-Rose, V. Paul] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
[Szabo, Eva] NCI, Canc Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA.
RP Doria-Rose, VP (reprint author), NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
NR 160
TC 1
Z9 1
U1 0
U2 4
PU DEMOS MEDICAL PUBLICATIONS
PI NEW YORK
PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA
BN 978-1-936287-06-2
J9 CURR MULTIDISC ONCOL
PY 2011
BP 53
EP 72
PG 20
WC Oncology
SC Oncology
GA BRY52
UT WOS:000283895900005
ER
PT B
AU Mukhopadhyay, P
Gurusamy, N
Das, DK
AF Mukhopadhyay, Partha
Gurusamy, Narasimman
Das, Dipak K.
BE Dhalla, NS
Nagano, M
Ostadal, B
TI Stem Cell, MicroRNA and Redox Cycling
SO MOLECULAR DEFECTS IN CARDIOVASCULAR DISEASE
LA English
DT Article; Book Chapter
DE Cardiac stem cells; Resveratrol; Redox; Nrf2; Ref-1; NFkB; Heart;
Ischemia
ID BREAST-CANCER CELLS; HEMATOPOIETIC PROGENITOR CELLS; OXIDATIVE STRESS;
ADHESION MOLECULES; BONE-MARROW; PERIPHERAL-BLOOD;
MYOCARDIAL-INFARCTION; ANIMAL MICRORNAS; EMBRYOID BODIES; ISCHEMIC-HEART
AB Mobilization and homing of the hematopoietic stern cells appear to be regulated by mechanism involving redox cycling. Stem cells are localized inside bone marrow in a strictly hypoxic environment and must move to the injury site that is subjected to oxidative environment. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The major hitch in stem cell therapy includes the life of the stem cells after the stem cell therapy; most cells do not survive beyond 24-72 h. Sudden exposure of the stem cells from the hypoxic melieu into the oxidative environment likely causes severe injury to the cells. FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, while their differentiation process is regulated by redox factor protein-1, Ref-1. Lack of oxygen [hypoxia], specifically controlled hypoxia can stimulate the growth of the stem cells in their niche, and HIF-1 alpha plays a significant role in their maintenance and homing mechanism. Recently, resveratrol, a polyphenolic phytoalexin, prolonged the survival of the stem cells as evidenced by active proliferation and differentiation of the cells even after 4 months of cell therapy. The enhancement of stem cell survival was shown to be due to the ability of resveratrol to maintain a reduced tissue environment by over-expressing Nrf2 and Ref-1 in rat heart up to 6 months resulting in an enhancement of the regeneration of the adult cardiac stern cells as evidenced by increased cell survival and differentiation leading to improved cardiac function. Expression of stromal cell-derived factor (SDF) and myosin conclusively demonstrated homing of stem cells in the infracted myocardium, its regeneration leading to improvement of cardiac function.
C1 [Gurusamy, Narasimman; Das, Dipak K.] Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA.
[Mukhopadhyay, Partha] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
RP Das, DK (reprint author), Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA.
EM ddas@neuron.uchc.edu
NR 107
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7129-6
PY 2011
BP 69
EP 81
DI 10.1007/978-1-4419-7130-2_6
D2 10.1007/978-1-4419-7130-2
PG 13
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA BWR48
UT WOS:000294660600006
ER
PT B
AU Keusch, GT
AF Keusch, Gerald T.
BE Parker, R
Sommer, M
TI Models of Cooperation, Capacity Building, and the Future of Global
Health
SO ROUTLEDGE HANDBOOK OF GLOBAL PUBLIC HEALTH
LA English
DT Article; Book Chapter
C1 [Keusch, Gerald T.] Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02215 USA.
[Keusch, Gerald T.] Natl Inst Hlth, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Keusch, GT (reprint author), Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02215 USA.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-83272-1; 978-0-415-77848-0
PY 2011
BP 497
EP 505
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA BVZ61
UT WOS:000293213300049
ER
PT B
AU Lee, TL
Cheung, AHH
Rennert, OM
Chan, WY
AF Lee, Tin-Lap
Cheung, Albert Hoi-Hung
Rennert, Owen M.
Chan, Wai-Yee
BE Zini, A
Agarwal, A
TI RNA Expression in Male Germ Cells During Spermatogenesis (Male Germ Cell
Transcriptome)
SO SPERM CHROMATIN: BIOLOGICAL AND CLINICAL APPLICATIONS IN MALE
INFERTILITY AND ASSISTED REPRODUCTION
LA English
DT Article; Book Chapter
DE RNA expression in germ cells; Spermatogenesis; Germ cell transcriptome;
Male germ cell development; Serial analysis of gene expression
ID LONG NONCODING RNAS; SEX-CHROMOSOME INACTIVATION; COMPREHENSIVE SAGE
DATABASE; MICROARRAY EXPERIMENT MIAME; TISSUE-SPECIFIC EXPRESSION; MOUSE
X-CHROMOSOME; GENE-EXPRESSION; ALTERNATIVE PROMOTERS; MINIMUM
INFORMATION; EMBRYONIC GONAD
AB Spermatogenesis is a key process in mammalian reproduction. This highly ordered process requires precise and well-controlled programs governed by dynamic patterns of gene expression. Some genes are exclusive to spermatogenic cells, while others are closely related to genes expressed in somatic: cells. Although key genes in male germ cell development have been identified, the biological mechanisms and transcripts that govern the programs of spermatogonial stem cell renewal, germ cell differentiation during spermatogenesis, or fertilization remain largely unknown. This is partly due to the lack of information on the identity of genes involved. However, with the advent of various high-throughput genomic assays, it is now possible to obtain the whole-genome RNA expression. This chapter provides a brief account of current knowledge of the male germ cell transcriptome as revealed by studies using expression profiling platforms such as microarray and Serial Analysis of Gene Expression (SAGE). Major findings with regard to transcriptional regulation, transcript diversity, and chromatin-related regulation during male germ cell development are reviewed.
C1 [Lee, Tin-Lap; Cheung, Albert Hoi-Hung; Chan, Wai-Yee] Chinese Univ Hong Kong, Sch Biomed Sci, Reprod Dev & Endocrinol Program, Shatin, Hong Kong, Peoples R China.
[Lee, Tin-Lap; Rennert, Owen M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Clin & Dev Genom, NIH, Bethesda, MD USA.
RP Lee, TL (reprint author), Chinese Univ Hong Kong, Sch Biomed Sci, Reprod Dev & Endocrinol Program, Shatin, Hong Kong, Peoples R China.
EM leetl@cuhk.edu.hk
RI Lee, Tin-Lap/A-7853-2009
OI Lee, Tin-Lap/0000-0002-6654-0988
NR 99
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1781-2
PY 2011
BP 107
EP 121
DI 10.1007/978-1-4419-6857-9_8
D2 10.1007/978-1-4419-6857-9
PG 15
WC Andrology; Reproductive Biology
SC Endocrinology & Metabolism; Reproductive Biology
GA BWP55
UT WOS:000294445300008
ER
PT B
AU Soekadar, SR
Birbaumer, N
Cohen, LG
AF Soekadar, Surjo R.
Birbaumer, Niels
Cohen, Leonardo G.
BE Kansaku, K
Cohen, LG
TI Brain-Computer Interfaces in the Rehabilitation of Stroke and
Neurotrauma
SO SYSTEMS NEUROSCIENCE AND REHABILITATION
LA English
DT Article; Book Chapter
ID TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; EVENT-RELATED
DESYNCHRONIZATION; NONINVASIVE CORTICAL STIMULATION; RANDOMIZED
CONTROLLED-TRIAL; MACHINE INTERFACES; MOVEMENT DIRECTION; SUBCORTICAL
STROKE; SKILL ACQUISITION; PREMOTOR AREAS
AB Paralysis after stroke or neurotrauma is among the leading causes of long term disability in adults. The development of brain-computer interface (BCI) systems that allow online classification of electric or metabolic brain activity and their translation into control signals of external devices or computers have led to two major approaches in tackling the problem of paralysis. While assistive Bel systems strive for continuous high-dimensional control of robotic devices or functional electric stimulation (FES) of paralyzed muscles to substitute for lost motor functions in a 'daily life environment (e.g. Velliste et al. 2008 [1]; Hochberg et al. 2006 [2]; Pfurtscheller et al. 2000 [3]), restorative BCI systems aim at normalization of neurophysiologic activity that might facilitate motor recovery (e.g. Birbaumer et al. 2007, 2009 [4, 5]; Daly et al. 2008 [6]). In order to make assistive BCI systems work in daily life, high BCI communication speed is necessary, an issue that by now can only be achieved by invasive recordings of brain activity (e.g. via multi-unit arrays, MUA, or electrocorticogram, ECoG). Restorative BCI systems, in contrast, were developed as training tools based on non-invasive methods such as electro- or magnetoencephalography (EEG/MEG). More recently developed approaches use real-time functional magnetic resonance imaging (rtfMRI) or near-infrared spectroscopy (NIRS). Here, we provide an overview of the current state in the development and application of assistive and restorative BCI and introduce novel approaches to improve BCI control with brain stimulation such as transcranial direct current stimulation (tDCS). The outlook of using BCI in rehabilitation of stroke and neurotrauma is discussed.
C1 [Soekadar, Surjo R.; Cohen, Leonardo G.] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bethesda, MD 20892 USA.
[Soekadar, Surjo R.; Birbaumer, Niels] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany.
[Birbaumer, Niels] Osped san Camillo, IRCCS, Venice, Italy.
RP Cohen, LG (reprint author), NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM cohenl@ninds.nih.gov; cohenl@ninds.nih.gov
OI Soekadar, Surjo R./0000-0003-1280-5538
NR 117
TC 13
Z9 13
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-4-431-53998-8
PY 2011
BP 3
EP 18
DI 10.1007/978-4-431-54008-3_1
D2 10.1007/978-4-431-54008-3
PG 16
WC Neurosciences; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA BWO16
UT WOS:000294371300001
ER
PT S
AU Zhou, XB
Wang, Y
Wang, HH
Pham, TD
Li, K
AF Zhou, Xiaobo
Wang, Yuan
Wang, Honghui
Pham, Tuan D.
Li, King
BE Pham, TD
Zhou, X
Tanaka, H
OyamaHiga, M
Jiang, X
Sun, C
Kowalski, J
Jia, X
TI Biomarker Motif Discovery by Integrating Mass Spectrometry and PPI
Network
SO 2011 INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MODELS FOR LIFE SCIENCES
(CMLS-11)
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT International Symposium on Computational Models for Life Sciences
(CMLS-11)
CY OCT 11-13, 2011
CL Toyama, JAPAN
SP IEEE Engn Med & Biol Soc (EMBS), IEEE Syst, Man & Cybernet Soc (SMCS), Chaos Technol Res Lab, Japan, Univ New S Wales, Canberra Campus, Topcon, Japan
DE Biomarker Motif; MS; PPI
ID CANCER; PATHWAYS; BIOLOGY; TOOL
AB Traditional mass spectrometry biomarker discovery studies which focus on single biomarkers or a panel of biomarkers have shown their limitations with low reproducibility. In this paper, we propose a novel biomarker motif discovery approach by integrating both mass spectrometry data and protein interaction network information together to identify biomarkers. A novel Bayesian score method is developed to score the protein subnetwork both from the expression of protein and from the protein interaction network structure. Compared with the previous biomarker discovery method, our biomarker motif identification method not only models the expression of each protein, but also the relationship of proteins affected by the protein-protein interaction network. The experiment results show that our proposed biomarker discovery method has a higher sensitivity and lower false discovery rates than previously used methods. When applying our biomarker motifs discovery approach to the real stroke mass spectrometry data, we can identify several biomarker motifs for ischemic stroke which can achieve a higher classification performance with high biological significance.
C1 [Zhou, Xiaobo; Wang, Yuan; Li, King] Methodist Hosp, Dept Radiol, Res Inst, Weill Cornell Med Coll, Houston, TX 77030 USA.
[Wang, Honghui] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
[Pham, Tuan D.] Univ New South Wales, Sch Informat Technol & Engn, Bioinformat Res Grp, Canberra, ACT 2600, Australia.
RP Zhou, XB (reprint author), Methodist Hosp, Dept Radiol, Res Inst, Weill Cornell Med Coll, Houston, TX 77030 USA.
FU NIH [1R01LM010185-01]; Simmons Family Foundation
FX This work is partially funded by NIH 1R01LM010185-01 (Zhou & Chang) and
Simmons Family Foundation (Zhou).
NR 16
TC 1
Z9 1
U1 0
U2 0
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0931-6
J9 AIP CONF PROC
PY 2011
VL 1371
BP 225
EP 233
DI 10.1063/1.3596646
PG 9
WC Physics, Applied
SC Physics
GA BWT24
UT WOS:000294779500025
ER
PT B
AU Aly, H
Berra, L
Kolobow, T
AF Aly, Hany
Berra, Lorenzo
Kolobow, Theodor
BE Esquinas, AM
TI Gravitational Force and Respiratory Colonization in Mechanical
Ventilation
SO APPLIED TECHNOLOGIES IN PULMONARY MEDICINE
LA English
DT Article; Book Chapter
ID BACTERIAL-COLONIZATION; PNEUMONIA; TUBE; ASPIRATION; POSITION;
ORIENTATION; TRIAL; CARE
C1 [Aly, Hany] George Washington Univ, Div Newborn Serv, Washington, DC 20037 USA.
[Aly, Hany] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Berra, Lorenzo] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Kolobow, Theodor] NHLBI, Pulm & Crit Care Med Branch, NIH, Bethesda, MD 20892 USA.
RP Aly, H (reprint author), George Washington Univ, Div Newborn Serv, 900 23rd St NW,Suite G-2092,Room G-132, Washington, DC 20037 USA.
EM haly@mfa.gwu.edu
NR 11
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
BN 978-3-8055-9584-1
PY 2011
BP 151
EP 155
PG 5
WC Respiratory System
SC Respiratory System
GA BSN62
UT WOS:000285026500026
ER
PT J
AU Triccas, JA
Winter, N
Feng, CG
West, NP
AF Triccas, James A.
Winter, Nathalie
Feng, Carl G.
West, Nicholas P.
TI Immunity to Mycobacterium tuberculosis
SO CLINICAL & DEVELOPMENTAL IMMUNOLOGY
LA English
DT Editorial Material
C1 [Triccas, James A.] Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2000, Australia.
[Winter, Nathalie] INRA Ctr Tours, F-37380 Nouzilly, France.
[Feng, Carl G.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
[West, Nicholas P.] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia.
RP Triccas, JA (reprint author), Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2000, Australia.
EM j.triccas@usyd.edu.au
RI West, Nicholas/C-3119-2008
NR 2
TC 0
Z9 0
U1 0
U2 7
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1740-2522
J9 CLIN DEV IMMUNOL
JI Clin. Dev. Immunol.
PY 2011
AR 406549
DI 10.1155/2011/406549
PG 2
WC Immunology
SC Immunology
GA 816RD
UT WOS:000294618900001
ER
PT J
AU Hartmann, DP
Pelzel, KE
Abbott, CB
AF Hartmann, Donald P.
Pelzel, Kelly E.
Abbott, Craig B.
BE Bornstein, MH
Lamb, ME
TI DESIGN, MEASUREMENT, AND ANALYSIS IN DEVELOPMENTAL RESEARCH
SO DEVELOPMENTAL SCIENCE: AN ADVANCED TEXTBOOK, SIXTH EDITION
LA English
DT Article; Book Chapter
ID CORRECT CONFIDENCE-INTERVALS; CHI-SQUARE TEST; PSYCHOLOGICAL-RESEARCH;
QUALITATIVE RESEARCH; LONGITUDINAL DATA; MISSING DATA; NONCENTRAL
DISTRIBUTIONS; INTEROBSERVER AGREEMENT; PARAMETER-ESTIMATION;
LINEAR-MODELS
C1 [Hartmann, Donald P.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
[Pelzel, Kelly E.] Univ Iowa, Iowa City, IA 52242 USA.
[Abbott, Craig B.] NICHHD, Bethesda, MD USA.
RP Hartmann, DP (reprint author), Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
NR 355
TC 6
Z9 6
U1 6
U2 8
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-84676-6
PY 2011
BP 109
EP 197
PG 89
WC Psychology, Developmental
SC Psychology
GA BUF20
UT WOS:000289073000005
ER
PT S
AU Kim, IC
Le, DX
Thoma, GR
AF Kim, In Cheol
Le, Daniel X.
Thoma, George R.
BE Agam, G
ViardGaudin, C
TI Automated Identification of Biomedical Article Type Using Support Vector
Machines
SO DOCUMENT RECOGNITION AND RETRIEVAL XVIII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Document Recognition and Retrieval XVIII
CY JAN 26-27, 2011
CL San Francisco, CA
SP Soc Imaging Sci & Technol, SPIE
DE "Comment-on"; "Comment-in"; Online biomedical documents; Support vector
machine
ID TEXT CATEGORIZATION
AB Authors of short papers such as letters or editorials often express complementary opinions, and sometimes contradictory ones, on related work in previously published articles. The MEDLINE (R) citations for such short papers are required to list bibliographic data on these "commented on" articles in a "CON" field. The challenge is to automatically identify the CON articles referred to by the author of the short paper (called "Comment-in" or CIN paper). Our approach is to use support vector machines (SVM) to first classify a paper as either a CIN or a regular full-length article (which is exempt from this requirement), and then to extract from the CIN paper the bibliographic data of the CON articles. A solution to the first part of the problem, identifying CIN articles, is addressed here. We implement and compare the performance of two types of SVM, one with a linear kernel function and the other with a radial basis kernel function (RBF). Input feature vectors for the SVMs are created by combining four types of features based on statistics of words in the article title, words that suggest the article type (letter, correspondence, editorial), size of body text, and cue phrases. Experiments conducted on a set of online biomedical articles show that the SVM with a linear kernel function yields a significantly lower false negative error rate than the one with an RBF. Our experiments also show that the SVM with a linear kernel function achieves a significantly higher level of accuracy, and lower false positive and false negative error rates by using input feature vectors created by combining all four types of features rather than any single type.
C1 [Kim, In Cheol; Le, Daniel X.; Thoma, George R.] Natl Lib Med, Lister Hill Natl Ctr Biomed Commun, Bethesda, MD 20894 USA.
RP Kim, IC (reprint author), Natl Lib Med, Lister Hill Natl Ctr Biomed Commun, 8600 Rockville Pike, Bethesda, MD 20894 USA.
EM ickim@mail.nih.gov
NR 17
TC 1
Z9 1
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-411-6
J9 PROC SPIE
PY 2011
VL 7874
AR 787403
DI 10.1117/12.873023
PG 9
WC Computer Science, Artificial Intelligence; Imaging Science &
Photographic Technology
SC Computer Science; Imaging Science & Photographic Technology
GA BWF21
UT WOS:000293784300002
ER
PT J
AU Feghali, MN
Mattison, DR
AF Feghali, Maisa N.
Mattison, Donald R.
TI Clinical Therapeutics in Pregnancy
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID CANCER RESISTANCE PROTEIN; COMPREHENSIVE ETHICAL FRAMEWORK; WASHINGTON
SPECIALIZED CENTER; P-GLYCOPROTEIN EXPRESSION; HUMAN PLACENTA; PERINATAL
OUTCOMES; MANAGEMENT ISSUES; EPILEPSY-FOCUS; DRUG-THERAPY; INTRAHEPATIC
CHOLESTASIS
AB Most drugs are not tested for use during pregnancy, consequently, labeling, which may include information about fetal safety, includes nothing about dosing, efficacy, or maternal safety. Yet these are concerns of health care providers considering treatment of disease during pregnancy. Therefore, the practitioner treats the pregnant woman with the same dose recommended for use in adults (typically men) or may decide not to treat the disease at all. However, is the choice of not treating a woman during pregnancy better than dealing with the challenges which accompany treatment? This paper, which summarizes metabolic and physiologic changes induced by pregnancy, illustrates that standard adult dosing is likely to be incorrect during pregnancy.
C1 [Feghali, Maisa N.] Washington Hosp Ctr, Dept Obstet & Gynecol, Washington, DC 20010 USA.
[Mattison, Donald R.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA.
RP Feghali, MN (reprint author), Washington Hosp Ctr, Dept Obstet & Gynecol, Washington, DC 20010 USA.
EM maisafeghali@gmail.com
RI Mattison, Donald/L-4661-2013
OI Mattison, Donald/0000-0001-5623-0874
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institute of Health
FX Funding for this paper has been provided in part by the Intramural
Program of the Eunice Kennedy Shriver National Institute of Child Health
and Human Development, National Institute of Health to D. R. Mattison.
NR 133
TC 21
Z9 22
U1 1
U2 5
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 783528
DI 10.1155/2011/783528
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 816YF
UT WOS:000294637300001
ER
PT J
AU Revilleza, MJ
Wang, R
Mans, J
Hong, MQ
Natarajan, K
Margulies, DH
AF Revilleza, Maria Jamela
Wang, Rui
Mans, Janet
Hong, Manqing
Natarajan, Kannan
Margulies, David H.
TI How the Virus Outsmarts the Host: Function and Structure of
Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer
Cell Surveillance
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID INHIBITORY RECEPTOR LY49A; MURINE CYTOMEGALOVIRUS; MOUSE
CYTOMEGALOVIRUS; CRYSTAL-STRUCTURE; NKG2D RECEPTOR; IMMUNE EVASION; NK
CELLS; GLYCOPROTEIN UL16; INFECTED-CELLS; RAE-1 ISOFORMS
AB Natural killer (NK) cells provide an initial host immune response to infection by many viral pathogens. Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral fitness. Onemechanism employed bymembers of the beta-herpesvirus family, which includes the cytomegaloviruses, is to modulate the expression of cell surface ligands recognized by NK cell activation molecules. A novel set of cytomegalovirus (CMV) genes, exemplified by the mouse m145 family, encode molecules that have structural and functional features similar to those of host major histocompatibility-encoded (MHC) class I molecules, some of which are known to contribute to immune evasion. In this review, we explore the function, structure, and evolution of MHC-I-like molecules of the CMVs and speculate on the dynamic development of novel immunoevasive functions based on the MHC-I protein fold.
C1 [Revilleza, Maria Jamela; Wang, Rui; Hong, Manqing; Natarajan, Kannan; Margulies, David H.] NIAID, Mol Biol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA.
[Mans, Janet] Univ Witwatersrand, Dept Virol, ZA-2050 Johannesburg, South Africa.
[Mans, Janet] Univ Pretoria, Dept Med Virol, ZA-0001 Pretoria, South Africa.
RP Margulies, DH (reprint author), NIAID, Mol Biol Sect, Immunol Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM dhm@nih.gov
RI Margulies, David/H-7089-2013;
OI Mans, Janet/0000-0001-6721-1177; Margulies, David/0000-0001-8530-7375
FU Laboratory of Immunology, National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Bethesda, MD
FX This work was supported by the Intramural Research Program of the
Laboratory of Immunology, National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Bethesda, MD.
NR 100
TC 14
Z9 14
U1 0
U2 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 724607
DI 10.1155/2011/724607
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 816YA
UT WOS:000294636800001
ER
PT B
AU Isogai, S
Fujita, M
AF Isogai, Sumio
Fujita, Misato
BE Naruse, K
Tanaka, M
Takeda, H
TI Anatomical Atlas of Blood Vascular System of Medaka
SO MEDAKA: A MODEL FOR ORGANOGENESIS, HUMAN DISEASE, AND EVOLUTION
LA English
DT Article; Book Chapter
AB The zebrafish and the medaka provide a number of advantageous features for the analysis of cardiovascular development. To fully exploit the advantages of the teleost fish, there must be detailed knowledge of the normal pattern of the vascular system from the embryo through to the adult, which enables us to detect the mutants, interpret the results of experimental or genetic perturbations, and conduct cross-species comparisons. We visualized the gill, intestinal, renal, and parietal (including brain and spinal cord) blood vascular systems in adult medaka using intravascular resin casting and dye injection methods. Here, we provide an anatomical atlas of blood vascular systems of adult fish with brief descriptions to give a morphological foundation for future cardiovascular research using the medaka.
C1 [Isogai, Sumio] Iwate Med Univ, Sch Med, Dept Anat, Morioka, Iwate 0208505, Japan.
[Isogai, Sumio; Fujita, Misato] NICHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA.
RP Isogai, S (reprint author), Iwate Med Univ, Sch Med, Dept Anat, Morioka, Iwate 0208505, Japan.
EM sisogai@iwate-med.ac.jp
NR 4
TC 3
Z9 3
U1 1
U2 2
PU SPRINGER-VERLAG TOKYO
PI TOKYO
PA 37-3, HONGO 3-CHOME BONKYO-KU, TOKYO, 113, JAPAN
BN 978-4-431-92690-0
PY 2011
BP 95
EP 109
DI 10.1007/978-4-431-92691-7_7
D2 10.1007/978-4-431-92691-7
PG 15
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA BVR90
UT WOS:000292615500007
ER
PT S
AU Pai, VM
Stein, A
Kozlowski, M
George, A
Kopace, R
Bennett, E
Auxier, JA
Wen, H
AF Pai, Vinay M.
Stein, Ashley
Kozlowski, Megan
George, Ashvin
Kopace, Rael
Bennett, Eric
Auxier, Julie A.
Wen, Han
BE Pelc, NJ
Samei, E
Nishikawa, RM
TI 3D Diffraction Tomography for Visualization of Contrast Media
SO MEDICAL IMAGING 2011: PHYSICS OF MEDICAL IMAGING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Physics of Medical Imaging
CY FEB 13-17, 2011
CL Lake Buena Vista, FL
SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE
DE diffraction; tomography; rat; contrast media; x-ray CT; lung imaging;
harmonic imaging; Talbot
ID SHEARING INTERFEROMETER; GRATING INTERFEROMETER; BEAM SPLITTER; RAY
AB In x-ray CT, the ability to selectively isolate a contrast agent signal from the surrounding soft tissue and bone can greatly enhance contrast visibility and enable quantification of contrast concentration. We present here a 3D diffraction tomography implementation for selectively retaining volumetric diffraction signal from contrast agent particles that are within a banded size range while suppressing the background signal from soft tissue and bone. For this purpose, we developed a CT implementation of a single-shot x-ray diffraction imaging technique utilizing gratings. This technique yields both diffraction and absorption images from a single grating-modulated projection image through analysis in the spatial frequency domain. A solution of iron oxide nano-particles, having very different x-ray diffraction properties from tissue, was injected into ex vivo chicken wing and in vivo rat specimens respectively and imaged in a 3D diffraction CT setup. Following parallel beam reconstruction, it is noted that while the soft tissue, bone and contrast media are observed in the absorption volume reconstruction, only the contrast media is observed in the diffraction volume reconstruction. This 3D diffraction tomographic reconstruction permits the visualization and quantification of the contrast agent isolated from the soft tissue and bone background.
C1 [Pai, Vinay M.; Kozlowski, Megan; George, Ashvin; Bennett, Eric; Wen, Han] NHLBI, NIH, Bethesda, MD 20892 USA.
RP Pai, VM (reprint author), NHLBI, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM paiv@mail.nih.gov
NR 12
TC 0
Z9 0
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8503-8
J9 PROC SPIE
PY 2011
VL 7961
AR 79611K
DI 10.1117/12.877390
PG 7
WC Engineering, Electrical & Electronic; Optics; Physics, Applied;
Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical
Imaging
GA BWL08
UT WOS:000294178500051
ER
PT B
AU Bassetti, M
Mikulska, M
Gea-Banacloche, J
Viscoli, C
AF Bassetti, Matteo
Mikulska, Malgorzata
Gea-Banacloche, Juan
Viscoli, Claudio
BE Safdar, A
TI Invasive Candidiasis in Management of Infections in Cancer Patients
SO PRINCIPLES AND PRACTICE OF CANCER INFECTIOUS DISEASES
SE Current Clinical Oncology Series
LA English
DT Article; Book Chapter
DE Candida; Beta-D-glucan; Echinocandin; Neutropenia
ID LIPOSOMAL AMPHOTERICIN-B; BLOOD-STREAM INFECTIONS; DOUBLE-BLIND TRIAL;
MULTICENTER RANDOMIZED-TRIAL; CLINICAL-PRACTICE GUIDELINES; SUCCESSFUL
MEDICAL-TREATMENT; NON-NEUTROPENIC PATIENTS; STEM-CELL TRANSPLANTS;
INTENSIVE-CARE-UNIT; BETA-D-GLUCAN
AB Candida infections are increasing. Nonalbicans Candida are now the most commonly isolated species in immunocompromised patients. The determination of serum beta-D-glucan may allow early diagnosis, but the best implementation of this new technology as screening or diagnostic test remains to be determined. From the therapeutic standpoint, the echinocandins have changed the management of invasive candidiasis due to their effectiveness and excellent safety and drug interaction profile.
C1 [Bassetti, Matteo; Mikulska, Malgorzata; Viscoli, Claudio] San Martino Hosp, Div Infect Dis, Genoa, Italy.
[Bassetti, Matteo; Mikulska, Malgorzata; Viscoli, Claudio] Univ Genoa, Genoa, Italy.
[Gea-Banacloche, Juan] NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA.
RP Viscoli, C (reprint author), San Martino Hosp, Div Infect Dis, Genoa, Italy.
EM viscoli@unige.it
NR 84
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-60761-643-6
J9 CURR CLIN ONCOL
PY 2011
BP 273
EP 281
DI 10.1007/978-1-60761-644-3_24
D2 10.1007/978-1-60761-644-3
PG 9
WC Oncology; Infectious Diseases
SC Oncology; Infectious Diseases
GA BVO36
UT WOS:000292077800024
ER
PT B
AU Rolston, KVI
Greenberg, DE
Safdar, A
AF Rolston, Kenneth V. I.
Greenberg, David E.
Safdar, Amar
BE Safdar, A
TI Infections Caused by Aerobic and Anaerobic Gram-Negative Bacilli
SO PRINCIPLES AND PRACTICE OF CANCER INFECTIOUS DISEASES
SE Current Clinical Oncology Series
LA English
DT Article; Book Chapter
DE Cancer; Pseudomonas; Stenotrophomonas; Drug-resistance; Antimicrobial
therapy; E. coli
ID BLOOD-STREAM INFECTIONS; FEBRILE NEUTROPENIC PATIENTS; IN-VITRO
SUSCEPTIBILITY; CANCER-PATIENTS; STENOTROPHOMONAS-MALTOPHILIA;
PSEUDOMONAS-AERUGINOSA; RISK-FACTORS; ANTIMICROBIAL SUSCEPTIBILITY;
HEMATOLOGICAL MALIGNANCIES; ONCOLOGY PATIENTS
AB Many cancer treatment centers have documented a decline in the proportion of bacterial infections caused by aerobic Gram-negative bacilli in the past 2 decades. Nevertheless, these organisms still cause a wide spectrum of infection (from benign colonization to disseminated disease) and are associated with substantial morbidity and mortality in patients with cancer, particularly during episodes of neutropenia. The most significant problem developed in the recent years has been the emergence of resistance among most Gram-negative pathogens, with some organisms acquiring multiple resistance mechanisms, which render them multi-drug-resistant. Exacerbating this problem is the fact that the pipeline for new drug development is relatively dry. This has led to the increased use of combination regimens and the revival of older agents such as colistin. Greater emphasis needs to be placed on antimicrobial stewardship and on strict adherence to infection control policies, in order to reduce the frequency of and limit the spread of these organisms. Bacteroides and other anaerobic Gram-negative bacteria may lead to life-threatening infections, presence of refractory hypotension, high-grade fever, acute intravascular hemolysis and disseminated coagulation, and early onset of tissue necrosis are the hallmark of this devastating disease. A high level of suspicion and prompt systemic therapy coupled with surgical excision of devitalized tissue when possible may improve outcomes.
C1 [Rolston, Kenneth V. I.; Safdar, Amar] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA.
[Greenberg, David E.] NIAID, Dept Infect Dis, Bethesda, MD 20892 USA.
RP Rolston, KVI (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, 1515 Holcombe Blvd,Unit 1460, Houston, TX 77030 USA.
EM krolston@mdanderson.org
NR 101
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-60761-643-6
J9 CURR CLIN ONCOL
PY 2011
BP 423
EP 433
DI 10.1007/978-1-60761-644-3_36
D2 10.1007/978-1-60761-644-3
PG 11
WC Oncology; Infectious Diseases
SC Oncology; Infectious Diseases
GA BVO36
UT WOS:000292077800036
ER
PT B
AU Sundaram, AK
Oktem, B
Razumovskaya, J
Jackson, SN
Woods, AS
Doroshenko, VM
AF Sundaram, Appavu K.
Oktem, Berk
Razumovskaya, Jane
Jackson, Shelley N.
Woods, Amina S.
Doroshenko, Vladimir M.
BE Ivanov, AR
Lazarev, AV
TI Sample Preparation in Biological Analysis by Atmospheric Pressure Matrix
Assisted Laser/Desorption Ionization (AP-MALDI) Mass Spectrometry
SO SAMPLE PREPARATION IN BIOLOGICAL MASS SPECTROMETRY
LA English
DT Article; Book Chapter
DE AP-MALDI MS; Proteomics; Tandem mass spectrometry; Tissue imaging;
Tryptic digestion
ID ION MOBILITY-TOFMS; LASER-DESORPTION/IONIZATION; BACILLUS-ANTHRACIS;
ARRAY BIOSENSOR; BRAIN-TISSUE; SPORES; IDENTIFICATION; MIXTURES;
PROTEINS; PEPTIDES
AB Rapid detection and identification of biological molecules is of utmost importance in a number of applications including clinical diagnosis and detection of foodborne pathogens as well as environmental contaminants. Mass spectrometry affords a high degree of accuracy (specificity) and sensitivity without a need for extensive sample purification. Atmospheric-pressure matrix-assisted laser desorption/ionization (AP-MALDI) mass spectrometry has become a useful technique in a number of important applications, including identification of proteins, and structural analysis of oligosaccharides, phosphopepticles, and lipids. Sample preparation methods for AP-MALDI mass spectrometry are relatively simple, rapid and can be easily automated for high throughput sample analysis. AP-MALDI MS/MS analysis has been successfully utilized to identify the presence of different types of bioagents such as Escherichia coli (E. coli), spores of several Bacilli, Saccharomyces cerevisiae (yeast), ovalbumin, and Clostridium botulinum Neurotoxin Type A in environmental samples. AP-MALDI imaging mass spectrometry is an emerging technique for direct analysis of biological tissue sections that can be useful for profiling spatial distribution of drugs, peptides and proteins in tissue sections of plants, animals, and humans.
C1 [Sundaram, Appavu K.; Oktem, Berk; Razumovskaya, Jane; Doroshenko, Vladimir M.] Sci & Engn Serv Inc, Columbia, MD 21046 USA.
[Jackson, Shelley N.; Woods, Amina S.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA.
RP Sundaram, AK (reprint author), Sci & Engn Serv Inc, Columbia, MD 21046 USA.
EM asundaram@apmaldi.com; oktem@apmaldi.com; jrazumovski@apmaldi.com;
shelley.jackson@nih.hhs.gov; awoods@intra.nida.nih.gov;
dorosh@apmaldi.com
NR 42
TC 0
Z9 0
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
BN 978-94-007-0758-0
PY 2011
BP 749
EP 764
DI 10.1007/978-94-007-0828-0_35
D2 10.1007/978-94-007-0828-0
PG 16
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA BVY63
UT WOS:000293148700036
ER
PT B
AU Yang, XP
O'Shea, JJ
Ghoreschi, K
Laurence, A
AF Yang, Xiang-Ping
O'Shea, John J.
Ghoreschi, Kamran
Laurence, Arian
BE Jiang, SP
TI Signal Transduction and T(H)17 Cell Differentiation
SO TH 17 CELLS IN HEALTH AND DISEASE
LA English
DT Article; Book Chapter
ID ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; INTERFERON-REGULATORY FACTOR-4;
HYPER-IGE SYNDROME; GROWTH-FACTOR-BETA; COLLAGEN-INDUCED ARTHRITIS;
HELPER TYPE-1 CELLS; TH17 CELLS; TGF-BETA; RETINOIC-ACID
AB The discovery of the interleukin (IL-)17-producing T cells (T(H)17) has markedly changed our view of T cell differentiation and T cell-mediated immunity. Characterization of the signaling pathways involved in the T(H)17 commitment has provided exciting new insights into the contributions of CD4(+) T cells to immunoregulation, host defense, and the pathogenesis of auto-immune diseases. Additionally, emerging data on conversion among polarized T helper cells have raised the question how we should view such concepts as lineage commitment, terminal differentiation, and plasticity of different T cell subtypes. The transcriptional regulatory events and epigenetic modifications that control T(H)17 cell differentiation are diverse and complex, and despite the intensive efforts on this subject, many questions remain to be answered. In this chapter, we focus on our current understanding of the signaling "pathways, molecular interactions, transcriptional events, and epigenetic modifications that result in T(H)17 differentiation and effector functions.
C1 [Yang, Xiang-Ping; O'Shea, John J.; Ghoreschi, Kamran; Laurence, Arian] NIAMSD, Lymphocyte Cell Biol Sect, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA.
RP Yang, XP (reprint author), NIAMSD, Lymphocyte Cell Biol Sect, Mol Immunol & Inflammat Branch, NIH, 10 Ctr Dr,Bldg 10,Room 13C103, Bethesda, MD 20892 USA.
EM yangx2@mail.nih.gov
NR 148
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-9370-0
PY 2011
BP 157
EP 182
DI 10.1007/978-1-4419-9371-7_8
D2 10.1007/978-1-4419-9371-7
PG 26
WC Immunology
SC Immunology
GA BVY59
UT WOS:000293148300008
ER
PT B
AU Valdez, P
Ouyang, WJ
AF Valdez, Patricia
Ouyang, Wenjun
BE Jiang, SP
TI The Roles of IL-22 and Its Related Family Members in the Pathogenesis of
Psoriasis
SO TH 17 CELLS IN HEALTH AND DISEASE
LA English
DT Article; Book Chapter
ID PLAQUE-TYPE PSORIASIS; DIFFERENTIATION-ASSOCIATED GENE-7; II CYTOKINE
RECEPTOR; INDUCER-LIKE CELLS; ROR-GAMMA-T; EPITHELIAL-CELLS; CUTTING
EDGE; MELANOMA DIFFERENTIATION; INDUCIBLE FACTOR; INTERLEUKIN 22
AB IL-22 is a T(H)17 cytokine. It belongs to IL-10 family of cytokines that also includes IL-10, IL-19, IL-20, IL-24, and IL-26. IL-26 is also produced by T(H)17 cells, while IL-24 is a T(H)2 cytokine. All of these cytokines can also be produced by other leukocytes. Cytokine networks play essential roles in the pathogenesis of psoriasis. In psoriatic skin, the expression of IL-19, IL-20, IL-22, IL-24 and IL-26 is elevated. Infiltrating immune cells are the primary cellular sources. However, the receptors for these cytokines are expressed mainly on epithelial cells, including keratinocytes, but not on leukocytes. In psoriatic skin, these cytokines induce epidermal keratinocytes to display many pathogenic features, including hyperplasia, abnormal differentiation, and overexpression of psoriasin and other psoriatic markers. These cytokines mediate the crosstalk between infiltrating immune cells and epidermal keratinocytes.
C1 [Ouyang, Wenjun] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA.
[Valdez, Patricia] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Ouyang, WJ (reprint author), Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA.
EM ouyang.wenjun@gene.com
NR 117
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-9370-0
PY 2011
BP 445
EP 462
DI 10.1007/978-1-4419-9371-7_24
D2 10.1007/978-1-4419-9371-7
PG 18
WC Immunology
SC Immunology
GA BVY59
UT WOS:000293148300024
ER
PT J
AU Boltz, VF
Ambrose, Z
Kearney, M
KewalRamani, V
Maldarelli, F
Mellors, JW
Coffin, JM
AF Boltz, V. F.
Ambrose, Z.
Kearney, M.
KewalRamani, V.
Maldarelli, F.
Mellors, J. W.
Coffin, J. M.
TI Ultrasensitive allele-specific PCR reveals rare pre-existing
drug-resistant variants and a large effective virus population size in
macaques infected with RT-SHIV
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
CT International Workshop on HIV and Hepatitis Virus Drug Resistance and
Curative Strategies
CY JUN 07-11, 2011
CL Los Cabos, MEXICO
C1 [Boltz, V. F.; Kearney, M.; KewalRamani, V.; Maldarelli, F.] NCI, Bethesda, MD 20892 USA.
[Ambrose, Z.; Mellors, J. W.] Univ Pittsburgh, Pittsburgh, PA USA.
[Coffin, J. M.] Tufts Univ, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
IS 4
BP A103
EP A103
PG 1
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OB
UT WOS:000294375700106
ER
PT J
AU Havens, PL
Mulligan, K
Hazra, R
Van Loan, MD
Pan, CG
Bethel, J
Rutledge, BN
Kapogiannis, BG
Flynn, PM
Lujan-Zilberman, J
Kiser, JJ
Baker, AM
Liu, NX
Worrell, C
Wilson, CM
Stephensen, CB
AF Havens, P. L.
Mulligan, K.
Hazra, R.
Van Loan, M. D.
Pan, C. G.
Bethel, J.
Rutledge, B. N.
Kapogiannis, B. G.
Flynn, P. M.
Lujan-Zilberman, J.
Kiser, J. J.
Baker, A. M.
Liu, N. X.
Worrell, C.
Wilson, C. M.
Stephensen, C. B.
CA ATN 063 Protocol Team
TI Safety and efficacy of once-monthly dosing of vitamin D3 (50,000 IU) in
HIV-infected youth: Adolescent Trials Network Study 063
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
C1 [Havens, P. L.; Pan, C. G.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Mulligan, K.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Hazra, R.; Kapogiannis, B. G.; Worrell, C.] Eunice Kennedy Shriver NICHD, Pediat Adolescent & Maternal AIDS Branch, NIH, Bethesda, MD USA.
[Van Loan, M. D.; Stephensen, C. B.] Univ Calif Davis, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
[Bethel, J.; Rutledge, B. N.] Westat Corp, Bethesda, MD USA.
[Flynn, P. M.] St Jude Childrens Hosp, Memphis, TN 38105 USA.
[Lujan-Zilberman, J.] Univ S Florida, Coll Med, Tampa, FL USA.
[Kiser, J. J.] Univ Colorado Denver, Aurora, CO USA.
[Baker, A. M.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA.
[Wilson, C. M.] Univ Alabama, Birmingham, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
SU 2
BP A9
EP A10
PG 2
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OD
UT WOS:000294375900012
ER
PT J
AU Kearney, M
Spindler, J
Shao, W
Stephens, R
O'Shea, A
Rehm, C
Poethke, C
Mellors, JW
Coffin, JM
Maldarelli, F
AF Kearney, M.
Spindler, J.
Shao, W.
Stephens, R.
O'Shea, A.
Rehm, C.
Poethke, C.
Mellors, J. W.
Coffin, J. M.
Maldarelli, F.
TI HIV-1 populations that persist in plasma after long-term suppressive ART
are more closely related to ancestral sequences than are pre-therapy
populations
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
CT International Workshop on HIV and Hepatitis Virus Drug Resistance and
Curative Strategies
CY JUN 07-11, 2011
CL Los Cabos, MEXICO
C1 [Kearney, M.; Spindler, J.; Poethke, C.; Maldarelli, F.] NIH, HIV Drug Resistance Program, Frederick, MD USA.
[Shao, W.; Stephens, R.] SAIC, Adv Boimed Comp Ctr, Frederick, MD USA.
[O'Shea, A.; Rehm, C.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[Mellors, J. W.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
[Coffin, J. M.] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
IS 4
BP A38
EP A38
PG 1
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OB
UT WOS:000294375700054
ER
PT J
AU Larder, BA
Revell, AD
Wang, D
Hamers, R
Tempelman, H
Barth, R
Wensing, AMJ
Morrow, C
Wood, R
DeWolf, F
Kaiser, R
Pozniak, A
Lane, HC
Montaner, JM
AF Larder, B. A.
Revell, A. D.
Wang, D.
Hamers, R.
Tempelman, H.
Barth, R.
Wensing, A. M. J.
Morrow, C.
Wood, R.
DeWolf, F.
Kaiser, R.
Pozniak, A.
Lane, H. C.
Montaner, J. M.
TI Modelling response to antiretroviral therapy without a genotype as a
clinical tool for resource-limited settings
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
CT International Workshop on HIV and Hepatitis Virus Drug Resistance and
Curative Strategies
CY JUN 07-11, 2011
CL Los Cabos, MEXICO
C1 [Larder, B. A.; Revell, A. D.; Wang, D.] HIV Resistance Response Database Initiat RDI, London, England.
[Hamers, R.] Univ Amsterdam, Acad Med Ctr, PharmAccess Fdn, NL-1105 AZ Amsterdam, Netherlands.
[Tempelman, H.] Ndlovu Care Grp, Elandsdoorn, South Africa.
[Barth, R.; Wensing, A. M. J.] Univ Med Ctr, Utrecht, Netherlands.
[Morrow, C.; Wood, R.] Desmond Tutu HIV Ctr, Cape Town, South Africa.
[DeWolf, F.] Netherlands HIV Monitoring Fdn, Amsterdam, Netherlands.
[Kaiser, R.] Univ Cologne, AREVIR Cohort, Cologne, Germany.
[Pozniak, A.] Chelsea & Westminster Hosp, London, England.
[Lane, H. C.] NIAID, Bethesda, MD 20892 USA.
[Montaner, J. M.] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada.
Royal Free Hosp, London NW3 2QG, England.
RI wensing, a.m.j./F-3005-2011; Wood, Robin/G-8509-2011
NR 0
TC 1
Z9 1
U1 0
U2 1
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
IS 4
BP A42
EP A42
PG 1
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OB
UT WOS:000294375700058
ER
PT J
AU Shao, W
Wilson, E
Brooks, J
Dewar, R
Rehman, T
Kearney, M
Rehm, C
Metcalf, J
Kottilil, S
Mellors, J
Coffin, J
Maldarelli, F
AF Shao, W.
Wilson, E.
Brooks, J.
Dewar, R.
Rehman, T.
Kearney, M.
Rehm, C.
Metcalf, J.
Kottilil, S.
Mellors, J.
Coffin, J.
Maldarelli, F.
TI Comparison of bioinformatic algorithms to identify recent HIV-1
infection
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
CT International Workshop on HIV and Hepatitis Virus Drug Resistance and
Curative Strategies
CY JUN 07-11, 2011
CL Los Cabos, MEXICO
C1 [Shao, W.; Kearney, M.] SAIC, Adv Biomed Comp Ctr, Frederick, MD USA.
[Wilson, E.; Maldarelli, F.] NCI, HIV Drug Resistance Program, Frederick, MD 21701 USA.
[Brooks, J.; Metcalf, J.] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Ottawa, ON, Canada.
[Dewar, R.; Rehman, T.] NCI, Collaborat Clin Resource Branch, SAIC Frederick, Frederick, MD 21701 USA.
[Rehm, C.] NIAID, Clin Res Sect, NIH, Bethesda, MD 20892 USA.
[Kottilil, S.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[Mellors, J.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
[Coffin, J.] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
IS 4
BP A155
EP A155
PG 1
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OB
UT WOS:000294375700147
ER
PT J
AU Tashima, KT
Coakley, E
Toma, J
Mollan, KR
Smeaton, L
Gandhi, R
Fichtenbaum, CJ
Eron, JJ
Andrade, A
Johnson, VA
Klingman, KL
Manzella, A
Napolitano, L
Haubrich, RH
AF Tashima, K. T.
Coakley, E.
Toma, J.
Mollan, K. R.
Smeaton, L.
Gandhi, R.
Fichtenbaum, C. J.
Eron, J. J.
Andrade, A.
Johnson, V. A.
Klingman, K. L.
Manzella, A.
Napolitano, L.
Haubrich, R. H.
TI A comparison of DNA and plasma Trofile results in a
treatment-experienced study population prior to initiation of new
antiretroviral regimens
SO ANTIVIRAL THERAPY
LA English
DT Meeting Abstract
CT International Workshop on HIV and Hepatitis Virus Drug Resistance and
Curative Strategies
CY JUN 07-11, 2011
CL Los Cabos, MEXICO
C1 [Tashima, K. T.] Miriam Hosp, Providence, RI 02906 USA.
[Mollan, K. R.; Smeaton, L.] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Cambridge, MA 02138 USA.
[Gandhi, R.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Fichtenbaum, C. J.] Univ Cincinnati, Cincinnati, OH 45221 USA.
[Eron, J. J.] Univ N Carolina, Chapel Hill, NC 27515 USA.
[Andrade, A.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
[Johnson, V. A.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA.
[Johnson, V. A.] Univ Alabama, Med Sch Birmingham, Tuscaloosa, AL 35487 USA.
[Klingman, K. L.] NIAID, HIV Res Branch TRP, DAIDS, NIH, Baltimore, MD USA.
[Haubrich, R. H.] Univ Calif San Diego, San Diego, CA 92103 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2011
VL 16
IS 4
BP A112
EP A112
PG 1
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 813OB
UT WOS:000294375700115
ER
PT B
AU Pinn, VW
Blehar, MC
AF Pinn, Vivian W.
Blehar, Mary C.
BE Rayburn, WF
Schulkin, J
TI Interdisciplinary Women's Health Research and Career Development
SO CHANGING LANDSCAPE OF ACADEMIC WOMEN'S HEALTH CARE IN THE UNITED STATES
SE International Library of Ethics Law and the New Medicine
LA English
DT Article; Book Chapter
DE Biomedical research careers; Interdisciplinary research; Physician
scientists; Women's health research; Sex differences research
ID TRANSLATIONAL RESEARCH; INTERNAL-MEDICINE; OPPORTUNITIES; CHALLENGES;
SCIENCE; DISEASE; MODEL
AB Since the 1970s, many leaders in biomedical research have warned about a looming national shortage of new physician investigators but evidence, especially for Women's Health, has been largely indirect or anecdotal. This chapter discusses the number of junior physician investigators, in either patient-oriented or basic science research, who are present in departments and who are needed to maintain a research mission.
C1 [Pinn, Vivian W.] NIH, Off Res Womens Health, US Dept HHS, Bethesda, MD 20817 USA.
[Blehar, Mary C.] Off Res Womens Hlth, Potomac, MD USA.
[Blehar, Mary C.] NIMH, Womens Programs, NIH, Potomac, MD USA.
RP Pinn, VW (reprint author), NIH, Off Res Womens Health, US Dept HHS, Bethesda, MD 20817 USA.
EM vivian.pinn@nih.gov; blehar.mary@gmail.com
NR 78
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
BN 978-94-007-0930-0
J9 INT LIBR ETH LAW NEW
PY 2011
VL 48
BP 53
EP 75
DI 10.1007/978-94-007-0931-7_4
D2 10.1007/978-94-007-0931-7
PG 23
WC Ethics; Public, Environmental & Occupational Health; Law; Medical Ethics
SC Social Sciences - Other Topics; Public, Environmental & Occupational
Health; Government & Law; Medical Ethics
GA BUS90
UT WOS:000290246100004
ER
PT J
AU Moses, JM
AF Moses, Joshua M.
BE Brenner, GH
Bush, DH
Moses, J
TI An Anthropologist Among Disaster Caregivers
SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN
DISASTER RELIEF WORK
LA English
DT Article; Book Chapter
C1 [Moses, Joshua M.] CUNY, Grad Ctr, New York, NY 10021 USA.
[Moses, Joshua M.] Natl Inst Mental Hlth Ruth L Kirschstein, Bethesda, MD USA.
[Moses, Joshua M.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Moses, JM (reprint author), CUNY, Grad Ctr, New York, NY 10021 USA.
NR 4
TC 1
Z9 1
U1 0
U2 1
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-20386-953-6
PY 2011
BP 19
EP 23
PG 5
WC Psychology, Clinical; Social Work; Religion
SC Psychology; Social Work; Religion
GA BUP96
UT WOS:000290017600004
ER
PT J
AU Pandya, A
AF Pandya, Anand
BE Brenner, GH
Bush, DH
Moses, J
TI Ethical and Legal Considerations in Postdisaster Interdisciplinary
Collaborations
SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN
DISASTER RELIEF WORK
LA English
DT Article; Book Chapter
C1 [Pandya, Anand] NYU, Sch Med, New York, NY 10003 USA.
[Pandya, Anand] Bellevue Hosp, New York, NY USA.
[Pandya, Anand] Amer Psychiat Assoc, Sci Program Comm, Washington, DC 20005 USA.
[Pandya, Anand] NIMH, Bethesda, MD USA.
[Pandya, Anand] Cedars Sinai Med Ctr, Los Angeles, CA USA.
[Pandya, Anand] Natl Alliance Mental Illness NAMI Natl, Arlington, VA USA.
[Pandya, Anand] Disaster Psychiat Outreach, New York, NY USA.
[Pandya, Anand] Columbia Univ, New York State Psychiat Inst, New York, NY 10027 USA.
RP Pandya, A (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-20386-953-6
PY 2011
BP 75
EP 82
PG 8
WC Psychology, Clinical; Social Work; Religion
SC Psychology; Social Work; Religion
GA BUP96
UT WOS:000290017600007
ER
PT J
AU Smith, RP
Taylor, J
Larkin, GL
North, CS
Ryan, D
Holmes, A
AF Smith, Rebecca P.
Taylor, Julie
Larkin, Gregory Luke
North, Carol S.
Ryan, Diane
Holmes, Anastasia
BE Brenner, GH
Bush, DH
Moses, J
TI On Reentering the Chapel Models for Collaborations Between
Psychiatrists, Communities of Faith, and Faith-Based Providers After
Hurricane Katrina
SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN
DISASTER RELIEF WORK
LA English
DT Article; Book Chapter
C1 [Smith, Rebecca P.] Mt Sinai Med Ctr, New York, NY 10029 USA.
[Smith, Rebecca P.] NIMH, Bethesda, MD USA.
[North, Carol S.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[North, Carol S.] VA N Texas Hlth Care Syst, Program Trauma & Disaster, Dallas, TX USA.
[Larkin, Gregory Luke] Yale Univ, Sch Med, New Haven, CT 06520 USA.
[Larkin, Gregory Luke] CDC, Natl Ctr Injury Control & Prevent, Atlanta, GA 30333 USA.
[Larkin, Gregory Luke] CDC, NIMH, Atlanta, GA 30333 USA.
[Larkin, Gregory Luke] CDC, SAMHSA, Atlanta, GA 30333 USA.
[Larkin, Gregory Luke] Guys & St Thomas NHS Trust, London, England.
[Larkin, Gregory Luke] British Council, Guys St Thomas Kings Sch Med, London, England.
RP Smith, RP (reprint author), Mt Sinai Med Ctr, New York, NY 10029 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-20386-953-6
PY 2011
BP 125
EP 132
PG 8
WC Psychology, Clinical; Social Work; Religion
SC Psychology; Social Work; Religion
GA BUP96
UT WOS:000290017600011
ER
PT B
AU Gullo, MJ
Dawe, S
McHugh, MJ
AF Gullo, Matthew J.
Dawe, Sharon
McHugh, Meredith J.
BE Bardo, MT
Fishbein, DH
Milich, R
TI Impulsivity and Adolescent Substance Use: From Self-Report Measures to
Neuroimaging and Beyond
SO INHIBITORY CONTROL AND DRUG ABUSE PREVENTION: FROM RESEARCH TO
TRANSLATION
LA English
DT Article; Book Chapter
ID USE DISORDERS; PERSONALITY-TRAITS; YOUNG ADULTHOOD; BEHAVIORAL
ACTIVATION; 5-HTTLPR GENOTYPE; FRONTAL-CORTEX; ALCOHOL; CHILDHOOD;
METAANALYSIS; AGE
AB The capacity to regulate emotional impulses and pursue appropriate long-term goals is an integral part of adaptive human functioning. Therefore, it is not surprising that this capacity consistently emerges as a core trait in biologically-based models of personality. Variously labeled as "impulsivity," "sensation seeking," or "constraint" amongst other terms, variations in this trait reliably predict the development of substance use problems in prospective studies. Notably, marked increases in this impulsivity trait appear during adolescence a period of life when substance experimentation and abuse typically begins. In recent years, neuroimaging research has identified the orbitofrontal and anterior cingulate cortices as important neural substrates of trait impulsivity. Interestingly, these same brain regions undergo substantial development during the teenage years. Indeed, there is remarkable consistency in the time course of these neural changes with those at the level of personality, suggesting both the imaging scanner and the self-report questionnaire are tapping into the same underlying construct, albeit with a differing degree of precision. Despite its far greater precision, the scanner itself cannot be practically employed in large-scale prevention programs to identify teens at risk. However, in validating the biological basis of impulsivity, along with behavioral and self-report measures of the trait, neuroimaging research allows one to use these more cost-effective tools in primary prevention with greater confidence. Indeed, there is already evidence demonstrating the ability of such "blunt" tools to focus and improve prevention programs.
C1 [Dawe, Sharon] Griffith Univ, Sch Psychol, Brisbane, Qld 4101, Australia.
[Gullo, Matthew J.] Univ Liverpool, Inst Psychol Hlth & Soc, Liverpool L69 7ZA, Merseyside, England.
[McHugh, Meredith J.] NIDA IRP, Neuroimaging Res Branch, NIH, Baltimore, MD 21224 USA.
RP Dawe, S (reprint author), Griffith Univ, Sch Psychol, Mt Gravatt Campus, Brisbane, Qld 4101, Australia.
EM s.dawe@griffith.edu.au
RI Gullo, Matthew/C-3850-2008
OI Gullo, Matthew/0000-0003-3657-5191
NR 67
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1267-1
PY 2011
BP 161
EP 175
DI 10.1007/978-1-4419-1268-8_9
D2 10.1007/978-1-4419-1268-8
PG 15
WC Psychology, Clinical; Substance Abuse; Medicine, General & Internal
SC Psychology; Substance Abuse; General & Internal Medicine
GA BUR10
UT WOS:000290131200009
ER
PT S
AU Aman, JM
Yao, JH
Summers, RM
AF Aman, Javed M.
Yao, Jianhua
Summers, Ronald M.
BE Summers, RM
VanGinneken, B
TI Automatic Colonic Polyp Shape Determination using Content-Based Image
Retrieval
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE CT colonography; content-based image retrieval; polyp shape
ID CT COLONOGRAPHY; POPULATION
AB Polyp shape (sessile or pedunculated) may provide important clinical implication. However, the traditional way of determining polyp shape is both invasive and subjective. We present a less-invasive and automated method to predict the shape of colonic polyps on computed tomographic colonography (CTC) using the content-based image retrieval (CBIR) approach. We classify polyps as either sessile (SS) or pedunculated (PS) in shape. The CBIR uses numerical feature vectors generated from our CTC computer aided detection (CTC-CAD) system to describe the polyps. These features relate to physical and visual characteristics of the polyp. Feature selection was done using a support vector machine classifier on a training set of polyp shapes. The system is evaluated using an independent test set. Using receiver operating curve (ROC) analysis, we showed our system is as accurate as a polyp shape classifier. The area under the ROC curve was 0.86 (95% confidence interval [0.77, 0.93]).
C1 [Aman, Javed M.; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Aman, JM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM jyao@cc.nih.gov
NR 13
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79632G
DI 10.1117/12.878196
PG 7
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100083
ER
PT S
AU Caban, JJ
Liao, D
Yao, JH
Mollura, DJ
Gochuico, B
Yoo, T
AF Caban, Jesus J.
Liao, David
Yao, Jianhua
Mollura, Daniel J.
Gochuico, Bernadette
Yoo, Terry
BE Summers, RM
VanGinneken, B
TI Enhancing Image Classification Models with Multi-modal Biomarkers
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Data fusion; Physiological values; Multi-modal biomarkers;
Computer-aided Diagnosis; Pulmonary fibrosis
ID COMPUTER-AIDED DIAGNOSIS; LUNG; CT
AB Currently, most computer-aided diagnosis (CAD) systems rely on image analysis and statistical models to diagnose, quantify, and monitor the progression of a particular disease. In general, CAD systems have proven to be effective at providing quantitative measurements and assisting physicians during the decision-making process. As the need for more flexible and effective CADs continues to grow, questions about how to enhance their accuracy have surged.
In this paper, we show how statistical image models can be augmented with multi-modal physiological values to create more robust, stable, and accurate CAD systems. In particular, this paper demonstrates how highly correlated blood and EKG features can be treated as biomarkers and used to enhance image classification models designed to automatically score subjects with pulmonary fibrosis. In our results, a 3-5% improvement was observed when comparing the accuracy of CADs that use multi-modal biomarkers with those that only used image features. Our results show that lab values such as Erythrocyte Sedimentation Rate and Fibrinogen, as well as EKG measurements such as QRS and I:40, are statistically significant and can provide valuable insights about the severity of the pulmonary fibrosis disease.
C1 [Caban, Jesus J.; Liao, David; Yoo, Terry] NLM NIH, Off High Performance Comp, Bethesda, MD 20892 USA.
RP Caban, JJ (reprint author), NLM NIH, Off High Performance Comp, Bethesda, MD 20892 USA.
NR 13
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79631T
DI 10.1117/12.878084
PG 9
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100061
ER
PT S
AU Ehler, M
Dobrosotskaya, J
King, EJ
Czaja, W
Bonner, RF
AF Ehler, M.
Dobrosotskaya, J.
King, E. J.
Czaja, W.
Bonner, R. F.
BE Summers, RM
VanGinneken, B
TI Modeling Photo-bleaching Kinetics to Map Local Variations in Rod
Rhodopsin Density
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE rhodopsin bleaching; rod density; retinal lesions; confocal scanning
laser ophthalmoscope
ID DARK-ADAPTATION; ELECTRORETINOGRAM; RECOVERY; PIGMENT; WAVE
AB Localized rod photoreceptor and rhodopsin losses have been observed in post mortem histology both in normal aging and in age-related maculopathy. We propose to noninvasively map local rod rhodopsin density through analysis of the brightening of the underlying lipofuscin autofluorescence (LAF) in confocal scanning laser ophthalmoscopy (cSLO) imaging sequences starting in the dark adapted eye. The detected LAF increases as rhodopsin is bleached (time constant approximate to 25sec) by the average retinal irradiance of the cSLO 488nm laser beam. We fit parameters of analytical expressions for the kinetics of rhodopsin bleaching that Lamb validated using electroretinogram recordings in human. By performing localized (approximate to 100 mu m) kinetic analysis, we create high resolution maps of the rhodopsin density. This new noninvasive imaging and analysis approach appears well-suited for measuring localized changes in the rod photoreceptors and correlating them at high spatial resolution with localized pathological changes of the retinal pigment epithelium (RPE) seen in steady-state LAF images.
C1 [Ehler, M.; King, E. J.; Bonner, R. F.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Med Biophys, Bethesda, MD 20892 USA.
RP Ehler, M (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Med Biophys, 9 Mem Dr, Bethesda, MD 20892 USA.
EM ehlermar@mail.nih.gov
RI Bonner, Robert/C-6783-2015
NR 13
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79633R
DI 10.1117/12.878421
PG 7
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100129
ER
PT S
AU He, L
Long, LR
Antani, S
Thoma, G
AF He, Lei
Long, L. Rodney
Antani, Sameer
Thoma, George
BE Summers, RM
VanGinneken, B
TI Distribution Fitting-based Pixel Labeling for Histology Image
Segmentation
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Image segmentation; labeling; histology; local distribution fitting
ID CLASSIFICATION; MODEL
AB This paper presents a new pixel labeling algorithm for complex histology image segmentation. For each image pixel, a Gaussian mixture model is applied to estimate its neighborhood intensity distributions. With this local distribution fitting, a set of pixels having a full set of source classes (e.g. nuclei, stroma, connective tissue, and background) in their neighborhoods are identified as the seeds for pixel labeling. A seed pixel is labeled by measuring its intensity distance to each of its neighborhood distributions, and the one with the shortest distance is selected to label the seed. For non-seed pixels, we propose two different labeling schemes: global voting and local clustering. In global voting each seed classifies a non-seed pixel into one of the seed's local distributions, i.e., it casts one vote; the final label for the non-seed pixel is the class which gets the most votes, across all the seeds. In local clustering, each non-seed pixel is labeled by one of its own neighborhood distributions. Because the local distributions in a non-seed pixel neighborhood do not necessarily correspond to distinct source classes (i.e., two or more local distributions may be produced by the same source class), we first identify the "true" source class of each local distribution by using the source classes of the seed pixels and a minimum distance criterion to determine the closest source class. The pixel can then be labeled as belonging to this class. With both labeling schemes, experiments on a set of uterine cervix histology images show encouraging performance of our algorithm when compared with traditional multithresholding and K-means clustering, as well as state-of-the-art mean shift clustering, multiphase active contours, and Markov random field-based algorithms.
C1 [He, Lei; Long, L. Rodney; Antani, Sameer; Thoma, George] NIH, Natl Lib Med, Bethesda, MD 20894 USA.
RP He, L (reprint author), NIH, Natl Lib Med, 8600 Rockville Pike, Bethesda, MD 20894 USA.
OI Antani, Sameer/0000-0002-0040-1387
NR 23
TC 1
Z9 1
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79633D
DI 10.1117/12.877726
PG 10
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100115
ER
PT S
AU Liu, JM
Hua, J
Yao, JH
White, JM
Summers, RM
AF Liu, Jiamin
Hua, Jeremy
Yao, Jianhua
White, Jacob M.
Summers, Ronald M.
BE Summers, RM
VanGinneken, B
TI Computer-aided Abdominal Lymph Node Detection Using Contrast-enhanced CT
Images
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE lymph node detection; 3D blob detector; Hessian matrix; object scale
ID SEGMENTATION
AB Many malignant processes cause abdominal lymphadenopathy, and computed tomography (CT) has become the primary modality for its detection. A lymph node is considered enlarged (swollen) if it is more than 1 centimeter in diameter. Which lymph nodes are swollen depends on the type of disease and the body parts involved. Identifying their locations is very important to determine the possible cause. In the current clinical workflow, the detection and diagnosis of enlarged lymph nodes is usually performed manually by examining all slices of CT images, which can be error-prone and time consuming. 3D blob enhancement filter is a usual way for computer-aided node detection. We proposed an improved blob detection method for automatic lymph node detection in contrast-enhanced abdominal CT images. First, spine was automatically extracted to indicate abdominal region. Since lymph nodes are usually next to blood vessels, abdominal blood vessels were then segmented as a reference to set the search region for lymph nodes. Next, lymph node candidates were generated by object-scale Hessian analysis. Finally the detected candidates were segmented and some prior anatomical knowledge was utilized for false positive reduction. We applied our method to 9 patients with 11 enlarged lymph nodes and compared the results with the performance of the original multi-scale Hessian analysis. The sensitivities were 91% and 82% for our method and multi-scale Hessian analysis, respectively. The false positive rates per patient were 17 and 28 for our method and multi-scale Hessian analysis, respectively. Our results indicated that computer-aided lymph node detection with this blob detector may yield a high sensitivity and a relatively low FP rate in abdominal CT.
C1 [Liu, Jiamin; Hua, Jeremy; Yao, Jianhua; White, Jacob M.; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Dept Radiol & Imaging Sci, Imaging Biomarkers & Comp Aided Diag Lab, Bethesda, MD 20892 USA.
RP Liu, JM (reprint author), Natl Inst Hlth Clin Ctr, Dept Radiol & Imaging Sci, Imaging Biomarkers & Comp Aided Diag Lab, Bldg 10,Room 1C368X,MSC 1182, Bethesda, MD 20892 USA.
NR 17
TC 2
Z9 2
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 796313
DI 10.1117/12.878252
PG 7
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100036
ER
PT S
AU Wang, SJ
Petrick, N
Van Uitert, RL
Periaswamy, S
Summers, RM
AF Wang, Shijun
Petrick, Nicholas
Van Uitert, Robert L.
Periaswamy, Senthil
Summers, Ronald M.
BE Summers, RM
VanGinneken, B
TI 3D Supine and Prone Colon Registration for Computed Tomographic
Colonography Scans Based on Graph Matching
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE Computed Tomographic Colonography; graph matching; mean-field theory;
colon registration; normalized distance along the colon centerline
ID CT COLONOGRAPHY
AB In this paper, we propose a new registration method for supine and prone computed tomographic colonography scans based on graph matching. We first formulated 3D colon registration as a graph matching problem and utilized a graph matching algorithm based on mean field theory. During the iterative optimization process, one-to-one matching constraints were added to the system step-by-step. Prominent matching pairs found in previous iterations are used to guide subsequent mean field calculations. The advantage of the proposed method is that it does not require a colon centerline for registration. We tested the algorithm on a CTC dataset of 19 patients with 19 polyps. The average registration error of the proposed method was 4.0cm (std. 2.1cm). The 95% confidence intervals were [3.0cm, 5.0mm]. There was no significant difference between the proposed method and our previous method based on the normalized distance along the colon centerline (p=0.1).
C1 [Wang, Shijun; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Diag Lab, Bethesda, MD 20892 USA.
RP Wang, SJ (reprint author), Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Diag Lab, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA.
NR 10
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79631F
DI 10.1117/12.878227
PG 8
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100047
ER
PT S
AU Wei, ZS
Yao, JH
Wang, SJ
Summers, RM
AF Wei, Zhuoshi
Yao, Jianhua
Wang, Shijun
Summers, Ronald M.
BE Summers, RM
VanGinneken, B
TI Computer-aided Teniae Coli Detection Using Height Maps from Computed
Tomographic Colonography Images
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE CT colonography; teniae coli; Gabor filter banks
ID CT COLONOGRAPHY
AB Computed tomographic colonography (CTC) is a minimally invasive technique for colonic polyps and cancer screening. Teniae coli are three bands of longitudinal smooth muscle on the colon surface. They are parallel, equally distributed on the colon wall, and form a triple helix structure from the appendix to the sigmoid colon. Because of their characteristics, teniae coli are important anatomical meaningful landmarks on human colon. This paper proposes a novel method for teniae coli detection on CT colonography. We first unfold the three-dimensional (3D) colon using a reversible projection technique and compute the two-dimensional (2D) height map of the unfolded colon. The height map records the elevation of colon surface relative to the unfolding plane, where haustral folds corresponding to high elevation points and teniae to low elevation points. The teniae coli are detected on the height map and then projected back to the 3D colon. Since teniae are located where the haustral folds meet, we break down the problem by first detecting haustral folds. We apply 2D Gabor filter banks to extract fold features. The maximum response of the filter banks is then selected as the feature image. The fold centers are then identified based on piecewise thresholding on the feature image. Connecting the fold centers yields a path of the folds. Teniae coli are finally extracted as lines running between the fold paths. Experiments were carried out on 7 cases. The proposed method yielded a promising result with an average normalized RMSE of 5.66% and standard deviation of 4.79% of the circumference of the colon.
C1 [Wei, Zhuoshi; Yao, Jianhua; Wang, Shijun; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Dianosis Lab, Bethesda, MD 20892 USA.
RP Wei, ZS (reprint author), Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Dianosis Lab, Bethesda, MD 20892 USA.
EM rms@nih.gov
NR 13
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79631G
DI 10.1117/12.878257
PG 8
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100048
ER
PT S
AU Yao, JH
Dwyer, AJ
Summers, RM
Mollura, DJ
AF Yao, Jianhua
Dwyer, Andrew J.
Summers, Ronald M.
Mollura, Daniel J.
BE Summers, RM
VanGinneken, B
TI Computer-Aided Assessment of Pulmonary Disease in Novel Swine-Origin
H1N1 Influenza on CT
SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis
CY FEB 15-17, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc
DE H1N1 influenza; chest CT; computer aided diagnosis
ID LUNG; CLASSIFICATION; INFECTION
AB The 2009 pandemic is a global outbreak of novel H1N1 influenza. Radiologic images can be used to assess the presence and severity of pulmonary infection. We develop a computer-aided assessment system to analyze the CT images from Swine-Origin Influenza A virus (S-OIV) novel H1N1 cases. The technique is based on the analysis of lung texture patterns and classification using a support vector machine (SVM). Pixel-wise tissue classification is computed from the SVM value. The method was validated on four H1N1 cases and ten normal cases. We demonstrated that the technique can detect regions of pulmonary abnormality in novel H1N1 patients and differentiate these regions from visually normal lung (area under the ROC curve is 0.993). This technique can also be applied to differentiate regions infected by different pulmonary diseases.
C1 [Yao, Jianhua; Dwyer, Andrew J.; Summers, Ronald M.; Mollura, Daniel J.] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Yao, JH (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM jyao@cc.nih.gov
NR 18
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-505-2
J9 PROC SPIE
PY 2011
VL 7963
AR 79632W
DI 10.1117/12.878030
PG 7
WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear
Medicine & Medical Imaging
SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging
GA BWL95
UT WOS:000294211100098
ER
PT B
AU Higley, JD
Suomi, SJ
Chaffin, AC
AF Higley, J. Dee
Suomi, Stephen J.
Chaffin, Andrew C.
BE Weiss, A
King, JE
Murray, L
TI Impulsivity and Aggression as Personality Traits in Nonhuman Primates
SO PERSONALITY AND TEMPERAMENT IN NONHUMAN PRIMATES
SE Developments in Primatology-Progress and Prospects
LA English
DT Article; Book Chapter
ID CEREBROSPINAL-FLUID MONOAMINE; MACAQUES MACACA-MULATTA;
5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; TRANSPORTER GENE VARIATION;
PLASMA TESTOSTERONE LEVELS; MALE RHESUS-MONKEYS; OXIDASE-A GENE; SYSTEM
SEROTONERGIC RESPONSIVITY; CERCOPITHECUS-AETHIOPS-SABAEUS; EXCESSIVE
ALCOHOL-CONSUMPTION
AB Studies of macaques show that aggressiveness, along with its related cousin impulsivity, is trait-like, showing stable interindividual differences across time and situations. Two variations of aggressive temperament have been described: The first, aggressive temperament or overall aggressiveness, is characterized as competitive, marked by competition and a goal to win. While competitive and aggressive, such individuals seldom engage in violence. In competitive interchanges they often emerge as winners, and are typically high in social dominance. A second type of aggressive temperament leads to impulsive and unrestrained violence. This form of aggression has a strong relationship with impulse-control deficits. Evidence suggests that the two different forms of aggressiveness are mediated by differing systems, with competitive aggression mediated by testosterone. Impulsive aggression is mediated, at least in part by deficits in the serotonin system, with clear genetic and environmental underpinnings. These serotonin-impaired macaques show a variety of antisocial-like personality differences, exhibiting social alienation, sociosexual impairments, as well as impulse-control deficits, violence, and premature death, typically due to violent means. A variety of new molecular genetic studies show that the second form of aggressiveness is modulated, at least in part, by genetic x environmental interactions.
C1 [Higley, J. Dee; Chaffin, Andrew C.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
[Suomi, Stephen J.] NICHHD, Comparat Ethol Lab, Bethesda, MD 20892 USA.
RP Higley, JD (reprint author), Brigham Young Univ, Dept Psychol, 1042 SWKT, Provo, UT 84602 USA.
EM james_higley@byu.edu; suomis@lce.nichd.nih.gov; andrew_chaffin@byu.edu
NR 170
TC 5
Z9 5
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0175-9
J9 DEV PRIMATOL-PROG PR
JI Dev Primatol
PY 2011
BP 257
EP 283
DI 10.1007/978-1-4614-0176-6_10
D2 10.1007/978-1-4614-0176-6
PG 27
WC Behavioral Sciences; Zoology
SC Behavioral Sciences; Zoology
GA BWO19
UT WOS:000294382600010
ER
PT B
AU Suomi, SJ
Chaffin, AC
Higley, JD
AF Suomi, Stephen J.
Chaffin, Andrew C.
Higley, J. Dee
BE Weiss, A
King, JE
Murray, L
TI Reactivity and Behavioral Inhibition as Personality Traits in Nonhuman
Primates
SO PERSONALITY AND TEMPERAMENT IN NONHUMAN PRIMATES
SE Developments in Primatology-Progress and Prospects
LA English
DT Article; Book Chapter
ID MONKEYS MACACA-MULATTA; INFANT RHESUS-MONKEYS; 5-HYDROXYINDOLEACETIC
ACID CONCENTRATIONS; CORTICOTROPIN-RELEASING HORMONE; TRANSPORTER GENE
VARIATION; CEREBROSPINAL-FLUID MONOAMINE; EXCESSIVE ALCOHOL-CONSUMPTION;
POSITRON-EMISSION-TOMOGRAPHY; DIMINISHED SOCIAL COMPETENCE; FRONTAL
BRAIN ACTIVITY
AB While the history of the study of personality dates back to the early 1900s, most animal research, particularly on nonhuman primates, is much more recent. That personality in animals reflects our common evolutionary history is not surprising, and given our close genetic relatedness, should be expected. The personality trait that has received the most research in nonhuman primates is what we have called elsewhere, reactivity (others have referred to it as fearfulness, timidity, shyness, etc.). While several methods have been used to study it (including personality rating scales), generally, reactivity in nonhuman primates is most often measured using behavior codings. Two paradigms have received the most research: social separations and the human intruder paradigm. Individual differences in reactivity are stable across time and situations. Reactivity can also predict multiple behavioral outcomes, including enduring anxiety, low social dominance rank and submissiveness, high alcohol intake, and other forms of affective psychopathology. One major advantage of using nonhuman primates to model personality is that the underlying physiology and central nervous system foundations can be more readily studied than in humans. These studies show the importance of the amygdala and frontal cortex, as well as the HPA Axis, central norepinephrine, and serotonin in regulating reactivity. Studies also show the importance of early parental influence and genes on reactivity. Recent studies using molecular genetics show that the serotonin transporter and corticotrophin releasing hormone genes probably play important roles in its etiology but interact with early rearing history and situations to modulate reactivity.
C1 [Suomi, Stephen J.] NICHHD, Comparat Ethol Lab, Bethesda, MD 20892 USA.
[Chaffin, Andrew C.; Higley, J. Dee] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
RP Suomi, SJ (reprint author), NICHHD, Comparat Ethol Lab, 6105 Rockledge Dr,Suite 8030,MSC 7971, Bethesda, MD 20892 USA.
EM suomis@lce.nichd.nih.gov; andrew_chaffin@byu.edu; james_higley@byu.edu
NR 185
TC 2
Z9 2
U1 3
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0175-9
J9 DEV PRIMATOL-PROG PR
JI Dev Primatol
PY 2011
BP 285
EP 311
DI 10.1007/978-1-4614-0176-6_11
D2 10.1007/978-1-4614-0176-6
PG 27
WC Behavioral Sciences; Zoology
SC Behavioral Sciences; Zoology
GA BWO19
UT WOS:000294382600011
ER
PT J
AU Kessler, RC
Aguilar-Gaxiola, S
Alonso, J
Chatterji, S
Lee, S
Levinson, D
Ormel, J
Ustun, TB
Wang, PS
AF Kessler, Ronald C.
Aguilar-Gaxiola, Sergio
Alonso, Jordi
Chatterji, Somnath
Lee, Sing
Levinson, Daphna
Ormel, Johan
Uestuen, T. Bedirhan
Wang, Philip S.
BE Cohen, N
Galea, S
TI The burden of mental disorders worldwide Results from the World Mental
Health surveys
SO POPULATION MENTAL HEALTH: EVIDENCE, POLICY, AND PUBLIC HEALTH PRACTICE
SE Routledge Studies in Public Health
LA English
DT Article; Book Chapter
ID OF-THE-LITERATURE; PSYCHIATRIC-DISORDERS; ECONOMIC BURDEN;
SOCIAL-CONSEQUENCES; SURVEY REPLICATION; ANXIETY DISORDERS; GLOBAL
ASSESSMENT; MOOD DISORDERS; PREVALENCE; DISABILITY
C1 [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Aguilar-Gaxiola, Sergio] Univ Calif Davis, Ctr Reducing Hlth Dispar, Sch Med, Sacramento, CA 95817 USA.
[Aguilar-Gaxiola, Sergio] Univ Calif Davis, Clin & Translat Sci Ctr, Sch Med, Sacramento, CA 95817 USA.
[Alonso, Jordi] Hosp Mar, Hlth Serv Res Unit, IMEM, Res Inst, Barcelona, Spain.
[Alonso, Jordi] CIBERESP, Barcelona, Spain.
[Chatterji, Somnath] WHO, Dept Measurement & Hlth Informat Syst, CH-1211 Geneva, Switzerland.
[Lee, Sing] Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
[Levinson, Daphna] Minist Hlth, Mental Hlth Serv, Jerusalem, Israel.
[Ormel, Johan] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat & Psychiat Epidemiol, Univ Ctr Psychiat, NL-9713 AV Groningen, Netherlands.
[Uestuen, T. Bedirhan] WHO, EIP HFS, CH-1211 Geneva, Switzerland.
[Wang, Philip S.] NIMH, Bethesda, MD 20892 USA.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
RI Lee, Sing/O-2136-2015
NR 59
TC 0
Z9 0
U1 1
U2 4
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-81861-9
J9 ROUT STUD PUB HLTH
PY 2011
BP 9
EP 37
PG 29
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA BUV82
UT WOS:000290474800002
ER
PT J
AU Druss, BG
Wang, PS
Kessler, RC
AF Druss, Benjamin G.
Wang, Philip S.
Kessler, Ronald C.
BE Cohen, N
Galea, S
TI Mental health service utilization in the United States Past, present,
and future
SO POPULATION MENTAL HEALTH: EVIDENCE, POLICY, AND PUBLIC HEALTH PRACTICE
SE Routledge Studies in Public Health
LA English
DT Article; Book Chapter
ID FEDERAL-EMPLOYEES; INSURANCE PARITY; CARE; DISORDERS; TRENDS; ILLNESS;
PSYCHOTHERAPY; INCENTIVES; PREVALENCE; MOVEMENTS
C1 [Druss, Benjamin G.] Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Wang, Philip S.] NIMH, Bethesda, MD 20892 USA.
[Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
RP Druss, BG (reprint author), Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
NR 42
TC 0
Z9 0
U1 0
U2 3
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-81861-9
J9 ROUT STUD PUB HLTH
PY 2011
BP 195
EP 205
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA BUV82
UT WOS:000290474800011
ER
PT B
AU Jerome, LW
AF Jerome, Leigh W.
BE Saad, M
Zawdie, G
TI Triple Helix Knowledge Clusters Accelerating Innovation and Creating
Transformative Networks
SO THEORY AND PRACTICE OF THE TRIPLE HELIX SYSTEM IN DEVELOPING COUNTRIES:
ISSUES AND CHALLENGES
SE Routledge Studies in Innovation Organization and Technology
LA English
DT Article; Book Chapter
ID GLOBAL HEALTH; TECHNOLOGY; MODEL
C1 [Jerome, Leigh W.] Inst Triple Helix Innovat, Honolulu, HI 96822 USA.
[Jerome, Leigh W.] Amer Psychol Assoc, Washington, DC USA.
[Jerome, Leigh W.] WHO, Geneva, Switzerland.
[Jerome, Leigh W.] NIH, Bethesda, MD 20892 USA.
RP Jerome, LW (reprint author), Inst Triple Helix Innovat, Honolulu, HI 96822 USA.
NR 58
TC 0
Z9 0
U1 0
U2 4
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-83821-1; 978-0-415-47516-7
J9 ROUT STUD INNOV ORG
PY 2011
VL 16
BP 9
EP 24
PG 16
WC Economics; Operations Research & Management Science
SC Business & Economics; Operations Research & Management Science
GA BUU46
UT WOS:000290378100002
ER
PT B
AU Tullius, TD
Parker, SCJ
Margulies, EH
AF Tullius, Thomas D.
Parker, Stephen C. J.
Margulies, Elliott H.
BE Pontarotti, P
TI Evolutionary Constraint on DNA Shape in the Human Genome
SO EVOLUTIONARY BIOLOGY: CONCEPTS, BIODIVERSITY, MACROEVOLUTION AND GENOME
EVOLUTION
LA English
DT Proceedings Paper
CT 14th Evolutionary Biology Meeting
CY SEP 21-24, 2010
CL Marseilles, FRANCE
ID FUNCTIONAL ELEMENTS; IDENTIFICATION; RECOGNITION; PROJECT; SPECIFICITY;
MODENCODE; 1-PERCENT; BINDING
AB In the age of genomics, DNA is depicted as a string of letters. While this is a useful device for representing the information in a genome, the molecular nature of DNA is obscured. Proteins cannot actually "read" DNA letters they discriminate between DNA binding sites via molecular recognition, which is sensitive to DNA structure. Since shape is essential to DNA's biological function, we hypothesized that natural selection can act to preserve DNA shape without maintaining the exact sequence of nucleotides. To test this hypothesis, we developed a DNA structure database, ORChID, and used it to map structural variation throughout the human genome. We then devised a computational algorithm, Chai, to detect evolutionary constraint on DNA shape. We found that Chai regions correlate better with experimental functional elements than do genomic regions that are sequence-constrained. Our results support the hypothesis that DNA shape can be a substrate for natural selection.
C1 [Tullius, Thomas D.] Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA.
[Tullius, Thomas D.; Parker, Stephen C. J.] Boston Univ, Program Bioinform, Boston, MA 02215 USA.
[Parker, Stephen C. J.; Margulies, Elliott H.] NHGRI, Genome Inform Sec, Genome Tech Branch, NIH, Bethesda, MD 20892 USA.
RP Tullius, TD (reprint author), Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA.
EM tullius@bu.edu; stephen.parker@nih.gov; elliott@nhgri.nih.gov
RI Tullius, Thomas/A-9685-2008
OI Tullius, Thomas/0000-0003-4425-796X
FU National Human Genome Research Institute (NHGRI) of the NIH [R01
HG003541]; Intramural Research Program of the NHGRI, NIH; National
Academies Ford Foundation Dissertation Fellowship
FX This work was funded by a grant to T.D.T. from the National Human Genome
Research Institute (NHGRI) of the NIH (R01 HG003541). E.H.M. was
supported by the Intramural Research Program of the NHGRI, NIH. S.C.J.P.
was the recipient of a National Academies Ford Foundation Dissertation
Fellowship.
NR 19
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-20762-4
PY 2011
BP 243
EP +
DI 10.1007/978-3-642-20763-1_14
PG 3
WC Evolutionary Biology
SC Evolutionary Biology
GA BWF66
UT WOS:000293822500014
ER
PT S
AU Bagci, U
Udupa, JK
Chen, XJ
AF Bagci, Ulas
Udupa, Jayaram K.
Chen, Xinjian
BE Dawant, BM
Haynor, DR
TI Orientation Estimation of Anatomical Structures in Medical Images for
Object Recognition
SO MEDICAL IMAGING 2011: IMAGE PROCESSING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Image Processing
CY FEB 14-16, 2011
CL Lake Buena Vista, FL
SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE
DE Anatomy Segmentation; Object Recognition; Hermitian Matrices;
Non-Euclidean metrics; Multiple Object Recognition
AB Recognition of anatomical structures is an important step in model based medical image segmentation. It provides pose estimation of objects and information about "where" roughly the objects are in the image and distinguishing them from other object-like entities. In,(1) we presented a general method of model-based multiobject recognition to assist in segmentation (delineation) tasks. It exploits the pose relationship that can be encoded, via the concept of ball scale (b-scale), between the binary training objects and their associated grey images. The goal was to place the model, in a single shot, close to the right pose (position, orientation, and scale) in a given image so that the model boundaries fall in the close vicinity of object boundaries in the image. Unlike position and scale parameters, we observe that orientation parameters require more attention when estimating the pose of the model as even small differences in orientation parameters can lead to inappropriate recognition. Motivated from the non-Euclidean nature of the pose information, we propose in this paper the use of non-Euclidean metrics to estimate orientation of the anatomical structures for more accurate recognition and segmentation. We statistically analyze and evaluate the following metrics for orientation estimation: Euclidean, Log-Euclidean, Root-Euclidean, Procrustes Size-and-Shape, and mean Hermitian metrics. The results show that mean Hermitian and Cholesky decomposition metrics provide more accurate orientation estimates than other Euclidean and non-Euclidean metrics.
C1 [Bagci, Ulas] NIH, Ctr Clin, Bethesda, MD 20814 USA.
RP Bagci, U (reprint author), NIH, Ctr Clin, Off 1C370, Bethesda, MD 20814 USA.
EM ulasbagci@ieee.org
OI Bagci, Ulas/0000-0001-7379-6829
NR 7
TC 1
Z9 1
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-504-5
J9 PROC SPIE
PY 2011
VL 7962
AR 79622L
DI 10.1117/12.878184
PG 9
WC Engineering, Electrical & Electronic; Optics; Physics, Applied;
Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical
Imaging
GA BWK52
UT WOS:000294154900091
ER
PT S
AU Chen, XJ
Summers, RM
Yao, JH
AF Chen, Xinjian
Summers, Ronald M.
Yao, Jianhua
BE Dawant, BM
Haynor, DR
TI Automatic 3D Kidney Segmentation Based on Shape Constrained GC-OAAM
SO MEDICAL IMAGING 2011: IMAGE PROCESSING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Image Processing
CY FEB 14-16, 2011
CL Lake Buena Vista, FL
SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE
DE Kidney Segmentation; Active Appearance Models; Graph Cut; Live Wire
ID ALGORITHMS; FRAMEWORK
AB kidney can be classified into three main tissue types: renal cortex, renal medulla and renal pelvis (or collecting system). Dysfunction of different renal tissue types may cause different kidney diseases. Therefore, accurate and efficient segmentation of kidney into different tissue types plays a very important role in clinical research. In this paper, we propose an automatic 3D kidney segmentation method which segments the kidney into the three different tissue types: renal cortex, medulla and pelvis. The proposed method synergistically combines active appearance model (AAM), live wire (LW) and graph cut (GC) methods, GC-OAAM for short. Our method consists of two main steps. First, a pseudo 3D segmentation method is employed for kidney initialization in which the segmentation is performed slice-by-slice via a multi-object oriented active appearance model (OAAM) method. An improved iterative model refinement algorithm is proposed for the AAM optimization, which synergistically combines the AAM and LW method. Multi-object strategy is applied to help the object initialization. The 3D model constraints are applied to the initialization result. Second, the object shape information generated from the initialization step is integrated into the GC cost computation. A multi-label GC method is used to segment the kidney into cortex, medulla and pelvis. The proposed method was tested on 19 clinical arterial phase CT data sets. The preliminary results showed the feasibility and efficiency of the proposed method.
C1 [Chen, Xinjian; Summers, Ronald M.; Yao, Jianhua] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Chen, XJ (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM chenx6@mail.nih.gov; jyao@mail.nih.gov
NR 18
TC 0
Z9 0
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-504-5
J9 PROC SPIE
PY 2011
VL 7962
AR 79623M
DI 10.1117/12.878062
PG 8
WC Engineering, Electrical & Electronic; Optics; Physics, Applied;
Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical
Imaging
GA BWK52
UT WOS:000294154900127
ER
PT B
AU Elfrey, MK
Zieman, SJ
AF Elfrey, M. Kate
Zieman, Susan J.
BE Katlic, MR
TI Anticoagulation in the Older Surgical Patient
SO CARDIOTHORACIC SURGERY IN THE ELDERLY
LA English
DT Article; Book Chapter
DE Anticoagulation; Heparin; Bleeding; DVT prophylaxis; Warfarin; Direct
thrombin inhibitors; Prosthetic valves
ID CORONARY-ARTERY-DISEASE; DEEP-VEIN THROMBOSIS; VENA-CAVA FILTERS;
ATRIAL-FIBRILLATION; PULMONARY-EMBOLISM; INTRACRANIAL HEMORRHAGE;
ANTITHROMBOTIC THERAPY; STROKE PREVENTION; CLINICAL-PRACTICE; GUIDELINE
UPDATE
AB This chapter covers the delicate balance of the use of anticoagulation in older surgical patients, including those undergoing cardiothoracic (CT) surgery, and those with existing prosthetic valves who undergo other surgeries. Increasing age, alone, augments the risk of thromboembolic events in addition to comorbidities commonly seen in older patients (prior stroke, diabetes, atrial fibrillation and cancer). Older patients are also more prone to bleeding due to inadvertent over-anticoagulation, comorbidites (GI bleeding), and other medications affecting bleeding. Managing the older surgical patient on chronic oral anticoagulation therapy (OAT), when to stop therapy, when to use bridging therapy with heparin, when and how to reverse OAT, and how to resume OAT is covered. This section includes recommendations for patients with prosthetic heart valves. Strategies for venothromoembolism (VTE) prophylaxis in the perioperative period of specific surgeries is presented with multiple agents. Lastly, post-surgical conditions requiring anticoagulation such as VTE, atrial fibrillation, myocardial infarction, and valve implantation are presented. Age-specific reductions in warfarin loading and maintenance doses as well as strategies to reduce major bleeding events and intracranial hemorrhage are covered.
C1 [Zieman, Susan J.] NIA, NIH, Bethesda, MD 20892 USA.
[Elfrey, M. Kate] Johns Hopkins Bayview Hosp, Dept Internal Med, Baltimore, MD 21224 USA.
RP Zieman, SJ (reprint author), NIA, NIH, 7201 Wisconsin Ave,Suite 3C307, Bethesda, MD 20892 USA.
EM susan.zieman@nih.gov
NR 59
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-0891-9
PY 2011
BP 221
EP 239
DI 10.1007/978-1-4419-0892-6_17
D2 10.1007/978-1-4419-0892-6
PG 19
WC Cardiac & Cardiovascular Systems; Surgery
SC Cardiovascular System & Cardiology; Surgery
GA BVJ10
UT WOS:000291632500017
ER
PT B
AU Johnson, JL
Hrynkow, S
AF Johnson, Joy L.
Hrynkow, Sharon
BE Kirst, M
SchaeferMcDaniel, N
Hwang, S
OCampo, P
TI Funding Agencies and Transdisciplinary Research
SO CONVERGING DISCIPLINES: A TRANSDISCIPLINARY RESEARCH APPROACH TO URBAN
HEALTH PROBLEMS
LA English
DT Article; Book Chapter
C1 [Johnson, Joy L.] Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada.
[Johnson, Joy L.] Univ British Columbia, Sch Nursing, Vancouver, BC V5Z 1M9, Canada.
[Hrynkow, Sharon] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA.
RP Johnson, JL (reprint author), Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada.
NR 8
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6329-1
PY 2011
BP 149
EP 160
DI 10.1007/978-1-4419-6330-7_11
D2 10.1007/978-1-4419-6330-7
PG 12
WC Public, Environmental & Occupational Health; Urban Studies
SC Public, Environmental & Occupational Health; Urban Studies
GA BSN40
UT WOS:000285021000011
ER
PT J
AU Han, HJ
Park, SJ
Soh, KS
Myoung, HS
Lee, KJ
Ogay, V
Lee, YH
AF Han, Hyun-Jung
Park, Sang-Jun
Soh, Kwang-sup
Myoung, Hyoun-Seok
Lee, Kyoung-Joung
Ogay, Vyacheslav
Lee, Yong-Heum
TI Electrical Characterization of Proposed Transpositional Acupoints on the
Urinary Bladder Meridian in a Rat Model
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NEUROPEPTIDE-Y EXPRESSION; ACUPUNCTURE POINTS; IMPEDANCE; LOCI;
STIMULATION; SKIN
AB Specific electrical characteristics of acupoints were investigated on the urinary bladder (BL) meridian in 14 rats. BL acupoints and non-acupoints on the back were selected and their electrical voltages were measured by using a SPAC system. The mean voltages of each point or each line were statistically analyzed by using the ANOVA test. The BL meridian showed voltages higher than those of the reference line (P < .05). Bilateral 1st BL lines presented higher voltages than bilateral 2nd BL lines (P < .05). Most BL acupoints had voltages higher than those for the corresponding reference points (P < .05). In particular, the right BL16 exhibited the biggest difference from the reference point, followed by the left extra BL point-2, the right BL27, the left BL17, and the left BL45. Additionally, the distributions of neurofilamentsfor several points were investigated by using immunohistochemistry. There was a trend for the BL acupoints to have larger numbers of neurofilaments than the reference points, and that trend seemed to be directly proportional to the difference in voltage between the points. In conclusion, BL acupoints on the back in ratsexhibited specific electric and histologic characteristics. Therefore, those acupointsmay be utilized to investigate the efficacy of acupuncture with laboratory animals.
C1 [Myoung, Hyoun-Seok; Lee, Kyoung-Joung; Lee, Yong-Heum] Yonsei Univ, Dept Biomed Engn, Wonju 220710, Gangwon Do, South Korea.
[Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup] Seoul Natl Univ, Dept Phys & Astron, Biomed Phys Lab, Seoul 151747, South Korea.
[Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup] Seoul Natl Univ, Ctr Theoret Phys, Seoul 151747, South Korea.
[Ogay, Vyacheslav] Natl Biotechnol Ctr, Lab Immunochem & Immunobiotechnol, Astana 010000, Kazakhstan.
RP Lee, YH (reprint author), Yonsei Univ, Dept Biomed Engn, 234 Maeji Ri, Wonju 220710, Gangwon Do, South Korea.
EM koaim@yonsei.ac.kr
OI Soh, Kwang-Sup/0000-0001-8776-7877
FU Ministry of Commerce, Industry, and Energy of the Korean Government
[10028424]
FX This research was supported by a Grant from the Next Generation New
Technology Development Program (10028424) funded by the Ministry of
Commerce, Industry, and Energy of the Korean Government.
NR 35
TC 2
Z9 2
U1 0
U2 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1741-427X
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2011
AR 295475
DI 10.1155/2011/295475
PG 8
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 801AL
UT WOS:000293408700001
ER
PT B
AU Okunieff, P
Sundararaman, S
Metcalfe, S
Chen, Y
AF Okunieff, Paul
Sundararaman, Srinath
Metcalfe, Su
Chen, Yuhchyau
BE Gunderson, LL
Willett, CG
Calvo, FA
Harrison, LB
TI Biology of Large Dose per Fraction Irradiation
SO INTRAOPERATIVE IRRADIATION: TECHNIQUES AND RESULTS, SECOND EDITION
SE Current Clinical Oncology Series
LA English
DT Article; Book Chapter
DE Radiobiology of IORT; Tumor oxygenation; Hypoxic radiation sensitization
ID INTRAOPERATIVE RADIATION-THERAPY; BONE-MARROW-TRANSPLANTATION; ADVANCED
BREAST-CANCER; HYPOXIC TUMOR-CELLS; DNA TOPOISOMERASE-I; LARGE
ANIMAL-MODEL; MURINE FIBROSARCOMA; LOCAL IRRADIATION; MAMMARY-CARCINOMA;
PERIPHERAL-NERVE
C1 [Okunieff, Paul] Univ Florida, Dept Radiat Oncol, Gainesville, FL 32610 USA.
[Metcalfe, Su; Chen, Yuhchyau] Univ Rochester, Sch Med & Dent, Dept Radiat Oncol, Rochester, NY 14642 USA.
[Sundararaman, Srinath] NCI, Radiat Oncol Branch, Hollywood, FL 33021 USA.
RP Okunieff, P (reprint author), Univ Florida, Dept Radiat Oncol, 2033 Mowry Rd,Suite 145,POB 103633, Gainesville, FL 32610 USA.
EM Pokunieff@ufl.edu
NR 111
TC 4
Z9 4
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-61779-014-0
J9 CURR CLIN ONCOL
PY 2011
BP 27
EP 47
DI 10.1007/978-1-61779-015-7_2
D2 10.1007/978-1-61779-015-7
PG 21
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA BVL63
UT WOS:000291828200002
ER
PT J
AU Goldstein, BA
Polley, EC
Briggs, FBS
AF Goldstein, Benjamin A.
Polley, Eric C.
Briggs, Farren B. S.
TI Random Forests for Genetic Association Studies
SO STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY
LA English
DT Article
DE machine learning; SNP; genome wide association studies
ID GENOME-WIDE ASSOCIATION; VARIABLE IMPORTANCE; LOGISTIC-REGRESSION;
MULTIPLE-SCLEROSIS; SELECTION; CLASSIFICATION; SNPS; BIAS
AB The Random Forests (RF) algorithm has become a commonly used machine learning algorithm for genetic association studies. It is well suited for genetic applications since it is both computationally efficient and models genetic causal mechanisms well. With its growing ubiquity, there has been inconsistent and less than optimal use of RF in the literature. The purpose of this review is to breakdown the theoretical and statistical basis of RF so that practitioners are able to apply it in their work. An emphasis is placed on showing how the various components contribute to bias and variance, as well as discussing variable importance measures. Applications specific to genetic studies are highlighted. To provide context, RF is compared to other commonly used machine learning algorithms.
C1 [Goldstein, Benjamin A.] Stanford Univ, Dept Med, Quantitat Sci Unit, Stanford, CA 94305 USA.
[Polley, Eric C.] NCI, Biometr Res Branch, NIH, Bethesda, MD 20892 USA.
[Briggs, Farren B. S.] Univ Calif Berkeley, Genet Epidemiol & Genom Lab, Berkeley, CA 94720 USA.
RP Goldstein, BA (reprint author), Stanford Univ, Dept Med, Quantitat Sci Unit, Stanford, CA 94305 USA.
FU National Institutes of Health NRSA [T32 HG 00047]; Russell M. Grossman
Endowment
FX Benjamin A. Goldstein, Quantitative Sciences Unit, Department of
Medicine, Stanford University. Eric C. Polley, Biometric Research
Branch, National Cancer Institute, National Institutes of Health. Farren
B. S. Briggs, Genetic Epidemiology and Genomics Laboratory, University
of California, Berkeley. The authors acknowledge Alan Hubbard, Lisa
Barcellos and Adele Cutler for discussing and reviewing aspects of this
work. BAG was funded in part by a National Institutes of Health NRSA
Trainee appointment on grant T32 HG 00047 and the Russell M. Grossman
Endowment. FBSB is a National Multiple Sclerosis Society PostDoctoral
Fellow (FG 1847A1/1)
NR 65
TC 21
Z9 21
U1 3
U2 15
PU BERKELEY ELECTRONIC PRESS
PI BERKELEY
PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA
SN 1544-6115
J9 STAT APPL GENET MOL
JI Stat. Appl. Genet. Mol. Biol.
PY 2011
VL 10
IS 1
AR 32
DI 10.2202/1544-6115.1691
PG 35
WC Biochemistry & Molecular Biology; Mathematical & Computational Biology;
Statistics & Probability
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology;
Mathematics
GA 800XY
UT WOS:000293402200005
PM 22889876
ER
PT B
AU Silva, GS
Koroshetz, WJ
Gonzalez, RG
Schwamm, LH
AF Silva, Gisele S.
Koroshetz, Walter J.
Gonzalez, R. Gilberto
Schwamm, Lee H.
BE Gonzalez, RG
Hirsch, JA
Lev, MH
Schaefer, PW
Schwamm, LH
TI Causes of Ischemic Stroke
SO ACUTE ISCHEMIC STROKE: IMAGING AND INTERVENTION, SECOND EDITION
LA English
DT Article; Book Chapter
ID CERVICAL ARTERY DISSECTION; INTRACRANIAL ATHEROSCLEROTIC DISEASE; PATENT
FORAMEN OVALE; RECURRENT CEREBROVASCULAR EVENTS; SYSTEMIC
LUPUS-ERYTHEMATOSUS; HEALTH-CARE PROFESSIONALS; ATRIAL SEPTAL ANEURYSM;
CENTRAL-NERVOUS-SYSTEM; OF-NEUROLOGY AFFIRMS; GIANT-CELL ARTERITIS
C1 [Schwamm, Lee H.] Massachusetts Gen Hosp, Dept Neurol ACC 720, Boston, MA 02114 USA.
[Koroshetz, Walter J.] NINDS, Off Director, NIH, Bethesda, MD 20892 USA.
[Silva, Gisele S.] Univ Fed Sao Paulo, UNIFESP EPM, Sao Paulo, Brazil.
RP Schwamm, LH (reprint author), Massachusetts Gen Hosp, Dept Neurol ACC 720, 55 Fruit St, Boston, MA 02114 USA.
EM lscwamm@partners.org; lscwamm@partners.org
OI Schwamm, Lee/0000-0003-0592-9145
NR 94
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-12750-2
PY 2011
BP 25
EP 42
DI 10.1007/978-3-642-12751-9_2
PG 18
WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging; Peripheral Vascular Disease
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical
Imaging; Cardiovascular System & Cardiology
GA BSW03
UT WOS:000285942800002
ER
PT B
AU Rost, NS
Koroshetz, WJ
Gonzalez, RG
Schwamm, LH
AF Rost, Natalia S.
Koroshetz, Walter J.
Gonzalez, R. Gilberto
Schwamm, Lee H.
BE Gonzalez, RG
Hirsch, JA
Lev, MH
Schaefer, PW
Schwamm, LH
TI Clinical Management of Acute Stroke
SO ACUTE ISCHEMIC STROKE: IMAGING AND INTERVENTION, SECOND EDITION
LA English
DT Article; Book Chapter
ID ACUTE ISCHEMIC-STROKE; AMERICAN-HEART-ASSOCIATION; ANTITHROMBOTIC
THERAPY; THROMBOLYTIC THERAPY; GUIDELINES; STATEMENT; COUNCIL;
RECOMMENDATIONS; SCALE; UNIT
C1 [Gonzalez, R. Gilberto; Schwamm, Lee H.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
[Koroshetz, Walter J.] NINDS, NIH, Bethesda, MD 20892 USA.
[Rost, Natalia S.] Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Boston, MA 02114 USA.
RP Schwamm, LH (reprint author), Massachusetts Gen Hosp, Dept Neurol, 55 Fruit St, Boston, MA 02114 USA.
EM lscwamm@partners.org; lscwamm@partners.org
OI Schwamm, Lee/0000-0003-0592-9145
NR 24
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-12750-2
PY 2011
BP 211
EP 220
DI 10.1007/978-3-642-12751-9_10
PG 10
WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging; Peripheral Vascular Disease
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical
Imaging; Cardiovascular System & Cardiology
GA BSW03
UT WOS:000285942800010
ER
PT B
AU Brown, P
Reaman, GH
Seibel, NL
Kearns, P
AF Brown, Patrick
Reaman, Gregory H.
Seibel, Nita L.
Kearns, Pamela
BE Reaman, GH
Smith, FO
TI Promising Targeted Agents
SO CHILDHOOD LEUKEMIA: A PRACTICAL HANDBOOK
SE Pediatric Oncology
LA English
DT Article; Book Chapter
ID ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTERNAL TANDEM
DUPLICATION; HISTONE DEACETYLASE INHIBITOR; ACUTE MYELOGENOUS LEUKEMIA;
CHILDRENS ONCOLOGY GROUP; REFRACTORY HEMATOLOGIC MALIGNANCIES; DNA
METHYLTRANSFERASE INHIBITORS; ACUTE PROMYELOCYTIC LEUKEMIA; PRECLINICAL
TESTING PROGRAM
C1 [Brown, Patrick] Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD USA.
[Brown, Patrick] Sidney Kimmel Comprehens Canc Ctr, Dept Pediat, Baltimore, MD USA.
[Brown, Patrick] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Reaman, Gregory H.] George Washington Univ, Childrens Natl Med Ctr, Sch Med & Hlth Sci, Washington, DC 20010 USA.
[Seibel, Nita L.] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
[Kearns, Pamela] Univ Birmingham, Sch Canc Sci, Birmingham, W Midlands, England.
RP Brown, P (reprint author), Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD USA.
EM pbrown2@jhmi.edu; greaman@childrensoncologygroup.org
NR 184
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-13781-5
J9 PEDIATR ONCOL-BERLIN
PY 2011
BP 193
EP 214
DI 10.1007/978-3-642-13781-5_7
D2 10.1007/978-3-642-13781-5
PG 22
WC Oncology; Pediatrics
SC Oncology; Pediatrics
GA BTG39
UT WOS:000286902800007
ER
PT B
AU Smith, M
Devidas, M
Wheatley, K
Lock, RB
Hunsberger, S
AF Smith, Malcolm
Devidas, Meenakshi
Wheatley, Keith
Lock, Richard B.
Hunsberger, Sally
BE Reaman, GH
Smith, FO
TI Strategies for New Agent Development and Clinical Trial Considerations
SO CHILDHOOD LEUKEMIA: A PRACTICAL HANDBOOK
SE Pediatric Oncology
LA English
DT Article; Book Chapter
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; PRECLINICAL TESTING PROGRAM; CHILDRENS
ONCOLOGY GROUP; ACUTE MYELOID-LEUKEMIA; HUMAN TUMOR XENOGRAFTS; PHASE-I
TRIALS; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA;
REFRACTORY ACUTE-LEUKEMIA; B-CELL PRECURSOR
C1 [Smith, Malcolm] NCI, Pediat Sect, CIB, CTEP, Bethesda, MD 20892 USA.
[Devidas, Meenakshi] Childrens Oncol Grp, Ctr Data, Gainesville, FL 32601 USA.
[Wheatley, Keith] Univ Birmingham, Canc Res UK Clin Trials Unit, Sch Canc Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
[Lock, Richard B.] Childrens Canc Inst Australia Med Res, Leukaemia Biol Program, Randwick, NSW 2031, Australia.
[Hunsberger, Sally] NCI, Biometr Res Branch, Bethesda, MD 20892 USA.
RP Smith, M (reprint author), NCI, Pediat Sect, CIB, CTEP, 6130 Execut Blvd,Execut Plaza N,Rm 7025, Bethesda, MD 20892 USA.
EM malcolm.smith@nih.gov; mdevidas@cog.ufl.edu; k.wheatley@bham.ac.uk;
richard.lock@unsw.edu.au; sallyh@ctep.nci.nih.gov
RI Lock, Richard/G-4253-2013
NR 172
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-13781-5
J9 PEDIATR ONCOL-BERLIN
PY 2011
BP 215
EP 241
DI 10.1007/978-3-642-13781-5_8
D2 10.1007/978-3-642-13781-5
PG 27
WC Oncology; Pediatrics
SC Oncology; Pediatrics
GA BTG39
UT WOS:000286902800008
ER
PT B
AU Rader, C
AF Rader, Christoph
BE Medin, J
Fowler, D
TI Monoclonal Antibody Therapy for Cancer
SO EXPERIMENTAL AND APPLIED IMMUNOTHERAPY
LA English
DT Article; Book Chapter
DE Antibody engineering; Cancer; Hematologic malignancy; Solid malignancy;
Therapeutic monoclonal antibodies
ID METASTATIC COLORECTAL-CANCER; NON-HODGKINS-LYMPHOMA; GROWTH-FACTOR
RECEPTOR; B-CELL LYMPHOMA; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY;
IBRITUMOMAB TIUXETAN RADIOIMMUNOTHERAPY; IMMUNOTOXIN RFB4(DSFV)-PE38
BL22; CHRONIC LYMPHOCYTIC-LEUKEMIA; BREAST-CANCER; FOLLICULAR LYMPHOMA
AB Since the approval of rituximab (Rituxan (R)) for the treatment of B-cell non-Hodgkin's lymphoma (B-NHL) in 1997, nine additional monoclonal antibodies (mAbs) have been approved by the FDA for cancer therapy. Currently, more than 1,300 clinical studies registered at ClinicalTrials.gov investigate mAb therapy of cancer, including more than 150 phase III clinical trials. In concert with their clinical acceptance, mAbs in oncology have become commercially attractive. Four out of the ten approved mAbs have reached blockbuster status with annual sales exceeding $1 billion. The top three selling cancer drugs are all mAbs. These numbers indicate the potential of mAbs to play a leading role in cancer therapy for decades to come. Although mAbs provide a proven drug platform beyond the proof-of-concept stage, future success will depend on broadening and potentiating mAb therapy through antigen discovery, antibody engineering, use of mAbs in combination with chemotherapy and radiotherapy, and personalized medicine.
C1 NCI, Antibody Technol Sect, Expt Transplantat & Immunol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
RP Rader, C (reprint author), NCI, Antibody Technol Sect, Expt Transplantat & Immunol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
EM raderc@mail.nih.gov
NR 117
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-1-60761-979-6
PY 2011
BP 59
EP 83
DI 10.1007/978-1-60761-980-2_3
D2 10.1007/978-1-60761-980-2
PG 25
WC Oncology; Immunology; Medicine, Research & Experimental; Pathology
SC Oncology; Immunology; Research & Experimental Medicine; Pathology
GA BSY36
UT WOS:000286130400003
ER
PT B
AU McKay, MM
Bell, CC
Blake, CA
AF McKay, Mary M.
Bell, Carl C.
Blake, Clair A.
BE Pequegnat, W
Stover, E
Boyce, CA
TI Community-Based Collaborations: Designing, Conducting and Sustaining
Prevention Programs
SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL
AND BEHAVIORAL SCIENTISTS, SECOND EDITION
LA English
DT Article; Book Chapter
ID MENTAL-HEALTH-SERVICES; RESEARCH PARTNERSHIPS; BASIC RESEARCH;
PARTICIPATION; FAMILIES; CITIZEN; AIDS
C1 [McKay, Mary M.] Mt Sinai Sch Med, Dept Psychiat & Preventat Med, New York, NY 10029 USA.
[Bell, Carl C.] Univ Cent Lancashire, Fac Hlth, Inst Philosophy Divers & Mental Hlth, Ctr Ethn & Hlth, Preston PR1 2HE, Lancs, England.
[Bell, Carl C.] NIMH, CHAMP Family Program, Bethesda, MD 20892 USA.
[Blake, Clair A.] Mt Sinai Sch Med, Lab Dr Mary McKay, New York, NY USA.
RP McKay, MM (reprint author), Mt Sinai Sch Med, Dept Psychiat & Preventat Med, New York, NY 10029 USA.
EM mary.mckay@mssm.edu
NR 39
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1453-8
PY 2011
BP 9
EP 20
DI 10.1007/978-1-4419-1454-5_2
D2 10.1007/978-1-4419-1454-5
PG 12
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA BRQ12
UT WOS:000283396000002
ER
PT B
AU Lyman, W
Stanton, B
Pequegnat, W
AF Lyman, William
Stanton, Bonita
Pequegnat, Willo
BE Pequegnat, W
Stover, E
Boyce, CA
TI Reading Between the Lines of Your Summary Statement
SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL
AND BEHAVIORAL SCIENTISTS, SECOND EDITION
LA English
DT Article; Book Chapter
C1 [Lyman, William] Wayne State Univ, Sch Med, Carman & Ann Adams Dept Pediat, Detroit, MI 48202 USA.
[Lyman, William] Childrens Hosp Michigan, Detroit Med Ctr, Detroit, MI 48201 USA.
[Pequegnat, Willo] NIMH, Div AIDS, Bethesda, MD USA.
RP Lyman, W (reprint author), Wayne State Univ, Sch Med, Carman & Ann Adams Dept Pediat, Detroit, MI 48202 USA.
EM wlyman@med.wayne.edu
NR 0
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1453-8
PY 2011
BP 105
EP 113
DI 10.1007/978-1-4419-1454-5_9
D2 10.1007/978-1-4419-1454-5
PG 9
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA BRQ12
UT WOS:000283396000009
ER
PT B
AU Szapocznik, J
Pequegnat, W
Prado, G
AF Szapocznik, Jose
Pequegnat, Willo
Prado, Guillermo
BE Pequegnat, W
Stover, E
Boyce, CA
TI Designing an Intervention
SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL
AND BEHAVIORAL SCIENTISTS, SECOND EDITION
LA English
DT Article; Book Chapter
ID RANDOMIZED CONTROLLED-TRIAL; HISPANIC ADOLESCENTS; FAMILY-THERAPY;
SUBSTANCE USE; PREVENTION; EFFICACY; OUTCOMES
C1 [Szapocznik, Jose] Univ Miami, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA.
[Pequegnat, Willo] NIMH, Div AIDS, Bethesda, MD USA.
RP Szapocznik, J (reprint author), Univ Miami, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA.
EM Jszapocz@med.miami.edu
NR 26
TC 2
Z9 2
U1 2
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1453-8
PY 2011
BP 207
EP 227
DI 10.1007/978-1-4419-1454-5_17
D2 10.1007/978-1-4419-1454-5
PG 21
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA BRQ12
UT WOS:000283396000017
ER
PT B
AU Kleiner, DE
AF Kleiner, David E.
BE Ferrell, LD
Kakar, S
TI Drug-Induced Liver Injury
SO LIVER PATHOLOGY
SE Consultant Pathology
LA English
DT Article; Book Chapter
ID TOTAL PARENTERAL-NUTRITION; VANISHING BILE-DUCT; INDUCED INTRAHEPATIC
CHOLESTASIS; CHRONIC ACTIVE HEPATITIS; LACTIC-ACIDOSIS; AMIODARONE
HEPATOTOXICITY; INDUCED PHOSPHOLIPIDOSIS; HISTOPATHOLOGIC ANALYSIS;
SCLEROSING CHOLANGITIS; AUTOIMMUNE HEPATITIS
C1 NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
RP Kleiner, DE (reprint author), NCI, Pathol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA.
NR 89
TC 0
Z9 0
U1 0
U2 0
PU DEMOS MEDICAL PUBLICATIONS
PI NEW YORK
PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA
BN 978-1-933864-93-8
J9 CONSULT PATHOL
PY 2011
VL 4
BP 213
EP 242
PG 30
WC Gastroenterology & Hepatology; Pathology
SC Gastroenterology & Hepatology; Pathology
GA BUO60
UT WOS:000289931800015
ER
PT B
AU Moridani, MY
Araujo, RP
Johnson, CH
Lindon, JC
AF Moridani, Majid Y.
Araujo, Robyn P.
Johnson, Caroline H.
Lindon, John C.
BE Bonate, PL
Howard, DR
TI The -Omics in Drug Development
SO PHARMACOKINETICS IN DRUG DEVELOPMENT, VOL 3: ADVANCES AND APPLICATIONS
LA English
DT Article; Book Chapter
ID ABL TYROSINE KINASE; CHRONIC MYELOID-LEUKEMIA; DNA MICROARRAY DATA;
BREAST-CANCER; PROTEIN MICROARRAYS; SIGNALING NETWORKS; H-1-NMR-BASED
METABONOMICS; CLINICAL PROTEOMICS; MAGNETIC-RESONANCE; MASS-SPECTROMETRY
AB New advancement in genomics, proteomics, and metabonomics created significant excitement about the use of these relatively new technologies in drug design, discovery, development, and molecular-targeted therapeutics by identifying new drug targets and better tools for safety and efficacy studies in preclinical and clinical stages of drug development as well as diagnostics. In this chapter, we will briefly discuss the application of genomics, proteomics, and metabonomics in drug discovery and development.
C1 [Moridani, Majid Y.] Texas Tech Univ HSC, Dept Pharmaceut Sci, Sch Pharm, Amarillo, TX 79106 USA.
[Moridani, Majid Y.] Texas Tech Univ HSC, Dept Pediat, Sch Med, Amarillo, TX 79106 USA.
[Araujo, Robyn P.] George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA USA.
[Johnson, Caroline H.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Lindon, John C.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Biomol Med, London, England.
RP Moridani, MY (reprint author), Texas Tech Univ HSC, Dept Pharmaceut Sci, Sch Pharm, 1406 S Coulter Dr, Amarillo, TX 79106 USA.
EM majid.moridani@ttuhsc.edu
NR 79
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7936-0
PY 2011
BP 145
EP 173
DI 10.1007/978-1-4419-7937-7_7
D2 10.1007/978-1-4419-7937-7
PG 29
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA BTY16
UT WOS:000288417800007
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Atomic Bells and Frequency Finders
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 4
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 1
EP 18
DI 10.1007/978-3-642-16251-0_1
D2 10.1007/978-3-642-16251-0
PG 18
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200001
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Bonded Bells and Two-Dimensional Spectra
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 4
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 19
EP 42
DI 10.1007/978-3-642-16251-0_2
D2 10.1007/978-3-642-16251-0
PG 24
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200002
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Neighboring Bells and Structure Bundles
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 7
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 43
EP 73
DI 10.1007/978-3-642-16251-0_3
D2 10.1007/978-3-642-16251-0
PG 31
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200003
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Silencing of the Bells: Relaxation Theory Part One
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 4
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 75
EP 105
DI 10.1007/978-3-642-16251-0_4
D2 10.1007/978-3-642-16251-0
PG 31
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200004
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Relaxation Theory Part Two: Moving Atoms and Changing Notes
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 3
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 107
EP 129
DI 10.1007/978-3-642-16251-0_5
D2 10.1007/978-3-642-16251-0
PG 23
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200005
ER
PT B
AU Doucleff, M
Hatcher-Skeers, M
Crane, NJ
AF Doucleff, Michaeleen
Hatcher-Skeers, Mary
Crane, Nicole J.
BA Doucleff, M
HatcherSkeers, M
Crane, NJ
BF Doucleff, M
HatcherSkeers, M
Crane, NJ
TI Protein Dynamics
SO POCKET GUIDE TO BIOMOLECULAR NMR
LA English
DT Article; Book Chapter
ID MODEL-FREE APPROACH; NMR-SPECTROSCOPY; RELAXATION
C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA.
[Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA.
[Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA.
RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA.
EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu;
Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com;
Nicole.Crane@med.navy.mil
NR 7
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16250-3
PY 2011
BP 131
EP 156
DI 10.1007/978-3-642-16251-0_6
D2 10.1007/978-3-642-16251-0
PG 26
WC Biochemistry & Molecular Biology; Biology; Spectroscopy
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Spectroscopy
GA BUN31
UT WOS:000289825200006
ER
PT J
AU Qian, HH
Ripps, H
AF Qian, Haohua
Ripps, Harris
TI Neurovascular Interaction and the Pathophysiology of Diabetic
Retinopathy
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE-C; RETINAL GANGLION-CELLS;
NITRIC-OXIDE SYNTHASE; RECEPTOR RHO SUBUNITS; BLOOD-BRAIN-BARRIER; WHITE
PERCH RETINA; GABA RECEPTOR; OXIDATIVE STRESS; BIPOLAR CELLS
AB Diabetic retinopathy (DR) is the most severe of the several ocular complications of diabetes, and in the United States it is the leading cause of blindness among adults 20 to 74 years of age. Despite recent advances in our understanding of the pathogenesis of DR, there is a pressing need to develop novel therapeutic treatments that are both safe and efficacious. In the present paper, we identify a key mechanism involved in the development of the disease, namely, the interaction between neuronal and vascular activities. Numerous pathological conditions in the CNS have been linked to abnormalities in the relationship between these systems. We suggest that a similar situation arises in the diabetic retina, and we propose a logical strategy aimed at therapeutic intervention.
C1 [Qian, Haohua; Ripps, Harris] Univ Illinois, Coll Med, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
[Qian, Haohua] NEI, Bethesda, MD 20892 USA.
[Ripps, Harris] Univ Illinois, Coll Med, Dept Physiol & Biophys, Chicago, IL 60612 USA.
[Ripps, Harris] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL 60612 USA.
[Ripps, Harris] Marine Biol Lab, Mol Physiol Program, Woods Hole, MA 02543 USA.
RP Qian, HH (reprint author), Univ Illinois, Coll Med, Dept Ophthalmol & Visual Sci, 1855 W Taylor St, Chicago, IL 60612 USA.
EM haohua.qian@nih.gov
NR 125
TC 14
Z9 14
U1 1
U2 4
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2011
AR 693426
DI 10.1155/2011/693426
PG 11
WC Endocrinology & Metabolism; Medicine, Research & Experimental
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 803FM
UT WOS:000293567100001
ER
PT J
AU Rowzee, AM
Cawley, NX
Chiorini, JA
Di Pasquale, G
AF Rowzee, Anne M.
Cawley, Niamh X.
Chiorini, John A.
Di Pasquale, Giovanni
TI Glucagon-Like Peptide-1 Gene Therapy
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID BETA-CELL PROLIFERATION; IN-VIVO EXPRESSION; INSULIN SENSITIVITY; MOUSE
MODEL; PROGLUCAGON; PANCREAS; MICE; SECRETION; GLUCOSE; GLP-1
AB Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut. Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva of H. suspectum or Gila monster, is a peptide that shares sequence and functional homology with GLP-1. Both peptides have been demonstrated to stimulate insulin secretion, inhibit glucagon secretion, promote satiety and slow gastric emptying. As such, GLP-1 and Exendin-4 have become attractive pharmaceutical targets as an adjunctive therapy for individuals with type II diabetes mellitus, with several products currently available clinically. Herein we summarize the cell biology leading to GLP-1 production and secretion from intestinal L-cells and the endocrine functions of this peptide and Exendin-4 in humans. Additionally, gene therapeutic applications of GLP-1 and Exendin-4 are discussed with a focus on recent work using the salivary gland as a gene therapy target organ for the treatment of diabetes mellitus.
C1 [Rowzee, Anne M.; Chiorini, John A.; Di Pasquale, Giovanni] Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Bethesda, MD 20892 USA.
[Cawley, Niamh X.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cellular Neurobiol Sect, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA.
RP Di Pasquale, G (reprint author), Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Bethesda, MD 20892 USA.
EM gd78i@nih.gov
OI Rowzee, Anne/0000-0003-1969-9133
NR 55
TC 5
Z9 5
U1 0
U2 6
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-5214
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2011
AR 601047
DI 10.1155/2011/601047
PG 5
WC Endocrinology & Metabolism; Medicine, Research & Experimental
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 803FF
UT WOS:000293566400001
ER
PT S
AU Kozlowski, M
Donohue, D
Chen, M
Daniels, M
Connelly, P
Jeffries, K
Clevenger, R
Wen, H
Pai, VM
AF Kozlowski, M.
Donohue, D.
Chen, M.
Daniels, M.
Connelly, P.
Jeffries, K.
Clevenger, R.
Wen, H.
Pai, V. M.
BE Lin, CP
Ntziachristos, V
TI Coronary wall imaging in mice using osmium tetroxide and micro-computed
tomography
SO MOLECULAR IMAGING III
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Molecular Imaging III
CY MAY 22-23, 2011
CL Munich, GERMANY
SP SPIE, Opt Soc Amer
DE Atherosclerosis; osmium tetroxide; microcomputed tomography; mouse
ID DISEASE; ATHEROTHROMBOSIS
AB Coronary artery disease (CAD) is a major cause of death in the United States and results from the accumulation of atherosclerotic plaques in the arteries of the heart. Plaques accumulate as the result of the retention of low-density lipoprotein (LDL) particles in the sub-endothelium of the arterial wall. In mouse aorta, these lesions form primarily at the branching sites or bifurcations. However, in the coronary system, data has shown that late-stage plaque formation occurs throughout the proximal segments of the arteries. In order to better understand plaque formation in the coronary arteries, we have developed an osmium tetroxide (OsO4) stained coronary wall imaging protocol performed using microcomputed tomography (microCT). OsO4 is a heavy metal contrast agent that readily binds to lipids. Our data in 3- to 25-week old C57BL6 wild-type mice shows that the coronary vessel walls are highlighted by the use of the contrast agent. We expect that this combination of OsO4 and microCT will allow us to investigate the coronary artery wall in atherogenesis models of mice to characterize plaque formation.
C1 [Kozlowski, M.; Chen, M.; Wen, H.; Pai, V. M.] NHLBI, Lab Imaging Phys Biochem & Biophys Core, NIH, Bethesda, MD 20892 USA.
RP Kozlowski, M (reprint author), NHLBI, Lab Imaging Phys Biochem & Biophys Core, NIH, Bldg 10, Bethesda, MD 20892 USA.
RI Wen, Han/G-3081-2010
OI Wen, Han/0000-0001-6844-2997
NR 10
TC 0
Z9 0
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-686-8
J9 PROC SPIE
PY 2011
VL 8089
AR 80890P
DI 10.1117/12.888991
PG 8
WC Optics; Imaging Science & Photographic Technology
SC Optics; Imaging Science & Photographic Technology
GA BWC12
UT WOS:000293397400011
ER
PT J
AU Liu, WM
Meyer, J
Scully, CG
Elster, E
Gorbach, AM
AF Liu, Wei-Min
Meyer, Joseph
Scully, Christopher G.
Elster, Eric
Gorbach, Alexander M.
TI Observing temperature fluctuations in humans using infrared imaging
SO QIRT JOURNAL
LA English
DT Article
DE thermoregulation; skin microvasculature; infrared imaging; low frequency
oscillation; wavelet phase coherence
ID OSCILLATIONS
AB In this work we demonstrate that functional infrared imaging is capable of detecting low frequency temperature fluctuations in intact human skin and revealing spatial, temporal, spectral, and time-frequency based differences among three tissue classes: microvasculature, large sub-cutaneous veins, and the remaining surrounding tissue of the forearm. We found that large veins have stronger contractility in the range of 0.005-0.06 Hz compared to the other two tissue classes. Wavelet phase coherence and power spectrum correlation analysis show that micro vasculature and skin areas without vessels visible by IR have high phase coherence in the lowest three frequency ranges (0.005-0.0095 Hz, 0.0095-0.02 Hz, and 0.02-0.06 Hz), whereas large veins oscillate independently.
C1 [Liu, Wei-Min; Elster, Eric] USN, Med Res Ctr, Silver Spring, MD USA.
[Liu, Wei-Min; Meyer, Joseph; Scully, Christopher G.; Gorbach, Alexander M.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA.
[Scully, Christopher G.] Worcester Polytech Inst, Worcester, MA 01609 USA.
RP Liu, WM (reprint author), USN, Med Res Ctr, Silver Spring, MD USA.
EM liuweim@mail.nih.gov; gorbach@helix.nih.gov
FU National Institute of Biomedical Imaging and Bioengineering, National
Institutes of Health; Naval Medical Research Center; U.S. Navy Bureau of
Medicine and Surgery, Office of Naval Research [602227D.0483.01.A0518
(MFEL)]
FX This research was supported, in part, by the Intramural Research Program
of the National Institute of Biomedical Imaging and Bioengineering,
National Institutes of Health and the Naval Medical Research Center.;
The views expressed in this manuscript are those of the authors and do
not reflect the official policy of the Department of the Army,
Department of the Navy, the Department of Defense or the United States
Government. This effort was supported (in part) by the U.S. Navy Bureau
of Medicine and Surgery under the Medical Development Program and Office
of Naval Research work unit number 602227D.0483.01.A0518 (MFEL). We are
military service members (or other employees of the U.S. Government).
This work was prepared as part of our official duties. Title 17 U.S.C.
105 provides the "Copyright protection under this title is not available
for any work of the United States Government." Title 17 U.S.C. 101
defines a U.S. Government work as a work prepared by a military service
member or employee of the U.S. Government as part of that person's
official duties.
NR 16
TC 4
Z9 4
U1 0
U2 0
PU LAVOISIER
PI CACHAN
PA 14, RUE DE PROVIGNY, 94236 CACHAN, FRANCE
SN 1768-6733
J9 QIRT J
JI QIRT J.
PD JAN-JUN
PY 2011
VL 8
IS 1
BP 21
EP 36
PG 16
WC Instruments & Instrumentation; Materials Science, Characterization &
Testing; Physics, Applied
SC Instruments & Instrumentation; Materials Science; Physics
GA 796NN
UT WOS:000293058100002
PM 23538682
ER
PT B
AU Akin, C
Metcalfe, DD
AF Akin, Cem
Metcalfe, Dean D.
BE Castells, MC
TI Mastocytosis and Mast Cell Activation Syndromes Presenting as
Anaphylaxis
SO ANAPHYLAXIS AND HYPERSENSITIVITY REACTIONS
LA English
DT Article; Book Chapter
DE Anaphylaxis; Mast cells; Mastocytosis; Mast cell activation disorders;
C-kit
ID SYSTEMIC MASTOCYTOSIS; IDIOPATHIC ANAPHYLAXIS; URTICARIA PIGMENTOSA;
FATAL REACTIONS; BONE-MARROW; TRYPTASE; EXPRESSION; RECEPTOR; DIAGNOSIS;
ALLERGY
AB Anaphylaxis results from mast cell degranulation induced by allergen-specific IgE as well as various non-IgE-mediated mechanisms. It has been recently demonstrated that intrinsic abnormalities in mast cells, such as presence of activating D816V c-kit mutation, may influence susceptibility to anaphylaxis, especially in patients with "idiopathic" or hymenoptera-induced anaphylaxis. However, despite an improved understanding of the role of clonal mast cell disease in susceptibility to anaphylaxis, the basis of an apparent increase in susceptibility in the majority of patients remains poorly understood. In this chapter, we will review the potential mechanisms of mast cell activation as well as the range of symptoms and the differential diagnosis of patients suspected of having a disease caused by mast cell activation. In addition, we offer a global classification for disorders involving mast cells.
C1 [Akin, Cem] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
[Metcalfe, Dean D.] NIAID, NIH, Bethesda, MD 20892 USA.
RP Akin, C (reprint author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
EM dmetcalfe@niaid.nih.gov
NR 46
TC 4
Z9 4
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-60327-950-5
PY 2011
BP 245
EP 256
DI 10.1007/978-1-60327-951-2_15
D2 10.1007/978-1-60327-951-2
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA BSZ26
UT WOS:000286149900015
ER
PT B
AU Kim, P
Evans, GW
AF Kim, Pilyoung
Evans, Gary W.
BE Booth, A
McHale, SM
Landale, NS
TI Family Resources, Genes, and Human Development
SO BIOSOCIAL FOUNDATIONS OF FAMILY PROCESSES
SE National Symposium on Family Issues
LA English
DT Proceedings Paper
CT 17th Annual Penn State Symposium on Family Issues
CY OCT 08-09, 2009
CL Penn State Univ, Univ Park Campus, PA
SP Populat Res Inst, Children Youth & Families Consortium, Prevent Res Ctr, Women's Studies Program, Dept Social, Labor Studies & Employment Relat, Dept Human Dev & Family Studies, Dept Anthropology & Psychol, Natl Inst Child Hlth & Human Dev
HO Penn State Univ
ID METHYLTRANSFERASE VAL(158)MET GENOTYPE; TRANSPORTER GENE; ENVIRONMENT
INTERACTION; NEURAL MECHANISMS; CHILDHOOD POVERTY; MATERNAL
RESPONSIVENESS; GLUCOCORTICOID-RECEPTOR; CUMULATIVE RISK; ALLOSTATIC
LOAD; DAILY HASSLES
AB We review the effects of genes and family resources on families and children. Poverty increases children's exposures to environmental risk factors such as child abuse, poor quality parenting, and suboptimal physical environment. These environmental risk factors interact with various genes to predict more behavioral problems in childhood. Relations between genes and environments are likely more complex than simple individual gene x environment interactions. In some cases, genetic or environmental factors may have different impacts in low- vs. high-SES groups. Finally, we speculate about biological mechanisms that may account for gene by environment interactions. Poverty and related environmental factors may interact with genes, which may lead to abnormal brain development as well as dysregulation in both neurotransmitters and neuroendocrine stress regulatory systems.
C1 [Kim, Pilyoung; Evans, Gary W.] NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA.
RP Kim, P (reprint author), NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA.
EM pilyoung.kim@nih.gov
FU W.T.; John D. and Catherine T. MacArthur Foundation Network
FX Preparation of this chapter was partially supported by the W.T. Grant
Foundation, the John D. and Catherine T. MacArthur Foundation Network on
Socioeconomic Status and Health.
NR 46
TC 1
Z9 1
U1 5
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7360-3
J9 NATL SYMP FAM ISS
PY 2011
BP 221
EP +
DI 10.1007/978-1-4419-7361-0_15
PG 4
WC Family Studies
SC Family Studies
GA BVX83
UT WOS:000293099400015
ER
PT J
AU Zhou, HB
You, JH
Qin, GY
Longnecker, MP
AF Zhou, Haibo
You, Jinhong
Qin, Guoyou
Longnecker, Matthew P.
TI A partially linear regression model for data from an outcome-dependent
sampling design
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
LA English
DT Article
DE Estimated likelihood; Outcome-dependent sampling; Penalized spline;
Semiparametric method
ID EMPIRICAL LIKELIHOOD METHOD; COGNITIVE-DEVELOPMENT; CHILDREN; 2-PHASE;
AGE; PENALTIES; RHYTHMS; SPLINES
AB The outcome-dependent sampling scheme has been gaining attention in both the statistical literature and applied fields. Epidemiological and environmental researchers have been using it to select the observations for more powerful and cost-effective studies. Motivated by a study of the effect of in utero exposure to poly-chlorinated biphenyls on children's intelligence quotient at age 7 years, in which the effect of an important confounding variable is non-linear, we consider a semiparametric regression model for data from an outcome-dependent sampling scheme where the relationship between the response and covariates is only partially parameterized. We propose a penalized spline maximum likelihood estimation for inference on both the parametric and the non-parametric components and develop their asymptotic properties. Through simulation studies and an analysis of the intelligence study, we compare the proposed estimator with several competing estimators. Practical considerations of implementing those estimators are discussed.
C1 [Zhou, Haibo] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
[Qin, Guoyou] Fudan Univ, Shanghai, Peoples R China.
[Longnecker, Matthew P.] NIH, Res Triangle Pk, NC USA.
RP Zhou, HB (reprint author), Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
EM zhou@bios.unc.edu
OI Longnecker, Matthew/0000-0001-6073-5322
FU National Institutes of Health [R01CA 79949]; National Institutes of
Health, National Institute of Environmental Health Sciences; National
Natural Science Foundation of China [10801039]
FX This work is supported by a grant from the National Institutes of Health
(R01CA 79949) (for Zhou, You and Qin) and in part by the intramural
research programme of the National Institutes of Health, National
Institute of Environmental Health Sciences (for Longnecker). Qin's work
is also partially supported by the National Natural Science Foundation
of China (10801039).
NR 38
TC 3
Z9 3
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0035-9254
J9 J R STAT SOC C-APPL
JI J. R. Stat. Soc. Ser. C-Appl. Stat.
PY 2011
VL 60
BP 559
EP 574
DI 10.1111/j.1467-9876.2010.00756.x
PN 4
PG 16
WC Statistics & Probability
SC Mathematics
GA 798TT
UT WOS:000293235800005
PM 21966030
ER
PT J
AU Carpenter, J
Moore, HM
Juhl, H
Thomas, G
Miranda, LB
AF Carpenter, Jane
Moore, Helen M.
Juhl, Hartmut
Thomas, Geraldine
Miranda, Lisa B.
TI What Improvements Would You Recommend in the Collection of Control
Samples?
SO BIOPRESERVATION AND BIOBANKING
LA English
DT Editorial Material
C1 [Carpenter, Jane] Univ Sydney, Westmead Millennium Inst, Australian Breast Canc Tissue Bank, Westmead, NSW 2145, Australia.
[Moore, Helen M.] NCI, Biospecimen Res Network, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA.
[Juhl, Hartmut] Indivumed GmbH, Inostics GmbH, D-20251 Hamburg, Germany.
[Thomas, Geraldine] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London W12 0HS, England.
[Miranda, Lisa B.] Trans Hit Biomarkers Inc, Biobank Relat, Montreal, PQ H2V 1B7, Canada.
[Miranda, Lisa B.] Bluechiip Ltd, Business Dev, Scoresby, Vic 3179, Australia.
RP Carpenter, J (reprint author), Univ Sydney, Westmead Millennium Inst, Australian Breast Canc Tissue Bank, Westmead, NSW 2145, Australia.
EM jane.carpenter@sydney.edu.au; moorehe@mail.nih.gov; juhl@indivumed.com;
gerry.thomas@imperial.ac.uk; lisa.miranda.007@gmail.com
NR 0
TC 1
Z9 1
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1947-5535
J9 BIOPRESERV BIOBANK
JI Biopreserv. Biobank.
PY 2011
VL 9
IS 2
SI SI
BP 129
EP 131
DI 10.1089/bio.2011.9210
PG 3
WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology
SC Cell Biology; Chemistry; Medical Laboratory Technology
GA 793FU
UT WOS:000292806600001
PM 24846239
ER
PT B
AU Asthagiri, AR
Kanter, AS
Oldfield, EH
Jane, JA
AF Asthagiri, Ashok R.
Kanter, Adam S.
Oldfield, Edward H.
Jane, John A., Jr.
BE Mehta, MP
Chang, SM
Guha, A
Newton, HB
Vogelbaum, MA
TI Transsphenoidal
SO PRINCIPLES AND PRACTICE OF NEURO-ONCOLOGY: A MULTIDISCIPLINARY APPROACH
LA English
DT Article; Book Chapter
ID SECRETING PITUITARY-ADENOMAS; HORMONE-RECEPTOR ANTAGONIST;
TRANS-SPHENOIDAL REMOVAL; OF-THE-LITERATURE; FOLLOW-UP; STEREOTACTIC
RADIOSURGERY; DIFFERENTIAL-DIAGNOSIS; CYTOTOXIC CHEMOTHERAPY;
RADIATION-THERAPY; CUSHINGS-SYNDROME
C1 [Asthagiri, Ashok R.] Natl Inst Neurol Disorders, Surg Neurol Branch, NIH, Bethesda, MD USA.
[Kanter, Adam S.] Univ Pittsburgh, Med Ctr, Dept Neurosurg, Philadelphia, PA USA.
[Oldfield, Edward H.] Univ Virginia Hlth Syst, Dept Neurosurg, Charlottesville, VA USA.
[Jane, John A., Jr.] Univ Virginia, Dept Neurosurg, Charlottesville, VA USA.
RP Asthagiri, AR (reprint author), Natl Inst Neurol Disorders, Surg Neurol Branch, NIH, Bethesda, MD USA.
NR 74
TC 0
Z9 0
U1 0
U2 0
PU DEMOS MEDICAL PUBLICATIONS
PI NEW YORK
PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA
BN 978-1-933864-78-5
PY 2011
BP 445
EP 452
PG 8
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA BRX16
UT WOS:000283823500054
ER
PT S
AU Chambers, RA
Lipska, BK
AF Chambers, R. Andrew
Lipska, Barbara K.
BE ODonnell, P
TI A Method to the Madness: Producing the Neonatal Ventral Hippocampal
Lesion Rat Model of Schizophrenia
SO ANIMAL MODELS OF SCHIZOPHRENIA AND RELATED DISORDERS
SE Neuromethods
LA English
DT Article; Book Chapter
DE Ventral hippocampus; neonatal lesions; ibotenic acid;
neurodevelopmental; methods
ID AMPHETAMINE; DAMAGE
AB The neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia has demonstrated broad heuristic utility as an investigative platform encompassing many of the behavioral, neurobiological, and developmental aspects of this devastating neuropsychiatric illness affecting 1% of all human beings. This chapter serves as an essential description of materials and methods for generating and verifying the NVHL model in rats, which continues to hold significant potential in helping us understand schizophrenia, comorbid disorders, and their neurodevelopmental dynamics. Many of the approaches described here can be modified or adapted for producing other types of neurodevelopmental models of behavioral disorders.
C1 [Chambers, R. Andrew] Indiana Univ Sch Med, Lab Translat Neurosci Dual Diag & Dev, Dept Psychiat, Indianapolis, IN USA.
[Lipska, Barbara K.] NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA.
RP Chambers, RA (reprint author), Indiana Univ Sch Med, Lab Translat Neurosci Dual Diag & Dev, Dept Psychiat, Indianapolis, IN USA.
NR 9
TC 4
Z9 4
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 0893-2336
BN 978-1-61779-156-7
J9 NEUROMETHODS
JI Neuromethods
PY 2011
VL 59
BP 1
EP 24
DI 10.1007/978-1-61779-157-4_1
PG 24
WC Cell Biology; Medicine, Research & Experimental; Neurosciences;
Psychiatry; Psychology
SC Cell Biology; Research & Experimental Medicine; Neurosciences &
Neurology; Psychiatry; Psychology
GA BVP49
UT WOS:000292220000001
ER
PT S
AU Belforte, JE
Nakazawa, K
AF Belforte, Juan E.
Nakazawa, Kazu
BE ODonnell, P
TI Genetically Engineered Mice for Schizophrenia Research
SO ANIMAL MODELS OF SCHIZOPHRENIA AND RELATED DISORDERS
SE Neuromethods
LA English
DT Article; Book Chapter
DE NMDA receptor; GABAergic neurons; conditional knockout; schizophrenia;
animal model; ketamine; MK-801; NMDAR hypomorph; Cre/IoxP
ID NMDA RECEPTOR HYPOFUNCTION; TARGETED POINT MUTATIONS; GLYCINE
BINDING-SITE; PREFRONTAL CORTEX; ANIMAL-MODELS; GLUTAMATERGIC
NEUROTRANSMISSION; PREPULSE INHIBITION; KETAMINE; PHENCYCLIDINE;
PSYCHOSIS
AB NMDA receptor (NMDAR) hypofunction theory of schizophrenia has been assessed in rodents with pharmacological intervention and global knockout strategy of NMDAR blockade. However, these manipulations of NMDAR function have been relatively coarse, affecting all NMDA receptors throughout the brain. Here we tested the effects of eliminating NMDA receptors in about half the interneurons located in the cortex and the hippocampus in early postnatal development by engineering "conditional knockout" mice. Remarkably, the mutant mice produced a variety of schizophrenia-related phenotypes.
C1 [Belforte, Juan E.] Univ Buenos Aires, Dept Fisiol, Buenos Aires, DF, Argentina.
[Nakazawa, Kazu] NIMH, Unit Genet Cognit & Behav, NIH, Bethesda, MD 20892 USA.
RP Belforte, JE (reprint author), Univ Buenos Aires, Dept Fisiol, Buenos Aires, DF, Argentina.
RI Nakazawa, Kazutoshi/J-6195-2015
OI Nakazawa, Kazutoshi/0000-0001-5699-9093
NR 51
TC 1
Z9 1
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 0893-2336
BN 978-1-61779-156-7
J9 NEUROMETHODS
JI Neuromethods
PY 2011
VL 59
BP 231
EP 242
DI 10.1007/978-1-61779-157-4_10
PG 12
WC Cell Biology; Medicine, Research & Experimental; Neurosciences;
Psychiatry; Psychology
SC Cell Biology; Research & Experimental Medicine; Neurosciences &
Neurology; Psychiatry; Psychology
GA BVP49
UT WOS:000292220000010
ER
PT B
AU Panchision, DM
AF Panchision, David M.
BE Phinney, DG
TI Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal
SO ADULT STEM CELLS: BIOLOGY AND METHODS OF ANALYSIS
SE Stem Cell Biology and Regenerative Medicine
LA English
DT Article; Book Chapter
DE Neural stem cell; Intermediate progenitor cell/Transit amplifying cell;
Neuroblast; Self-renewal; Multipotency; Clonal analysis; Cell cycle;
Mitogen; Morphogen; Symmetric division; Asymmetric division; Lateral
inhibition; Selection; Instruction; Neurogenesis
ID EPIDERMAL-GROWTH-FACTOR; SUBVENTRICULAR ZONE ASTROCYTES; SUBCORTICAL
WHITE-MATTER; NEURAL PROGENITOR CELLS; NERVOUS-SYSTEM; HIPPOCAMPAL
NEUROGENESIS; VASCULAR NICHE; INTERMEDIATE PROGENITORS; TRANSCRIPTION
FACTORS; SUBEPENDYMAL ZONE
AB Stem cells have defining properties that are suited for tissue homeostasis and repair, but a central issue is how these cells generate mature cell types without exhausting their capacity for self-renewal. This chapter focuses on the central nervous system (CNS) to exemplify the regulation of adult stem cell self-renewal in the service of organ function. Topics will include conventional and novel methods used to distinguish stem cells from other proliferating cell types and the pitfalls in attempting to precisely characterize stem cell function. These methods reveal that stem cells interpret multiple signals to control the balance of self-renewal and quiescence. Among the emerging themes is that stem cell self-renewal is dynamically regulated throughout life, is integrally connected with lineage specification, and reflects a conservation of many intrinsic and extrinsic mechanisms from fetal development.
C1 NIMH, Div Neurosci & Basic Behav Sci, NIH, Bethesda, MD 20892 USA.
RP Panchision, DM (reprint author), NIMH, Div Neurosci & Basic Behav Sci, NIH, Bethesda, MD 20892 USA.
EM panchisiond@mail.nih.gov
NR 118
TC 1
Z9 1
U1 0
U2 4
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-61779-001-0
J9 STEM CELLS BIOL REG
JI Stem Cell Biol. Regen. Med.
PY 2011
BP 3
EP 33
DI 10.1007/978-1-61779-002-7_1
D2 10.1007/978-1-61779-002-7
PG 31
WC Cell & Tissue Engineering; Developmental Biology
SC Cell Biology; Developmental Biology
GA BTU50
UT WOS:000288113800001
ER
PT B
AU Mezey, E
AF Mezey, Eva
BE Phinney, DG
TI Adult Stem Cell Plasticity Revisited
SO ADULT STEM CELLS: BIOLOGY AND METHODS OF ANALYSIS
SE Stem Cell Biology and Regenerative Medicine
LA English
DT Article; Book Chapter
DE Adult stem cells; Bone marrow-derived stem cells; Chimerism;
Neurogenesis; Tissue-specific stem cells; Transdifferentiation
ID BONE-MARROW-CELLS; CENTRAL-NERVOUS-SYSTEM; VERSUS-HOST-DISEASE;
EPITHELIAL-CELLS; IN-VIVO; MUSCLE REGENERATION; CANCER-THERAPIES;
SKELETAL-MUSCLE; STROMAL CELLS; NEUROLOGICAL DISEASES
AB Cell biologists have long realized that most cells do not live as long as the organisms they comprise; thus, cells in almost every tissue need to be renewed/replaced during the natural lifespan of the organism. Depending on the turnover rate of cells in any given organ, this process can be very frequent or very rare. Epithelial cells in the mouth and the GI tract are exposed to a variety of insults (such as heat, cold, extreme changes in pH, strong spices, etc.) and have a very fast turnover rate; nerve cells get wired during embryonal development and either do not turn over or have a very low turnover rate. The rest of the tissues are somewhere in between. This kind of tissue regeneration relies on undifferentiated tissue-specific stem cells (also known as somatic stem cells) that are found in all adult animals and humans and multiply by cell division. They replenish cells that die from old age and regenerate those that have been damaged.
Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Unlike embryonic stern cells, the use of adult stem cells in research and therapy is not considered to be controversial as they are derived from adult tissue samples rather than human embryos. They have mainly been studied in humans and model organisms such as mice and rats.
Adult stem cells can potentially be used (1) to help us understand basic biological mechanisms (2) to regenerate aged or damaged tissues, and (3) to improve the health of organs by releasing agents that promote growth or differentiation of cells. Below, I will try to summarize the present knowledge of adult stem cells with regard to their (trans)differentiation abilities. Due to the vast amount of literature available, I will focus on human data when they are available and refer the reader to reviews for more details than I can provide in the space available.
C1 Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA.
RP Mezey, E (reprint author), Natl Inst Dent & Craniofacial Res, NIH, Bldg 49,5A76 49 Convent Dr, Bethesda, MD 20892 USA.
EM mezeye@mail.nih.gov
NR 120
TC 1
Z9 1
U1 1
U2 6
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-61779-001-0
J9 STEM CELLS BIOL REG
JI Stem Cell Biol. Regen. Med.
PY 2011
BP 113
EP 131
DI 10.1007/978-1-61779-002-7_5
D2 10.1007/978-1-61779-002-7
PG 19
WC Cell & Tissue Engineering; Developmental Biology
SC Cell Biology; Developmental Biology
GA BTU50
UT WOS:000288113800005
ER
PT S
AU Bhangoo, SK
Petty, L
White, FA
AF Bhangoo, Sonia K.
Petty, Lauren
White, Fletcher A.
BE Ma, C
Zhang, JM
TI Animal Models of HIV-Associated Painful Sensory Neuropathy
SO ANIMAL MODELS OF PAIN
SE Neuromethods
LA English
DT Article; Book Chapter
ID ENVELOPE GLYCOPROTEIN GP120; PERIPHERAL NEUROPATHY; HYPERSENSITIVITY;
FACILITATION; INVOLVEMENT; NEURONS; STATES; DRUGS; RAT
AB Painful distal sensory neuropathy is the most common neurological complication of HIV1 infection. There are several neuropathic pain syndromes associated with the disease; however, the most common is a sensory neuropathy called HIV sensory neuropathy (HIV-SN). HIV-SN can be subdivided into subacute or chronic distal sensory polyneuropathy (DSP) and subacute antiretroviral-induced toxic neuropathy (ATN). Both forms involve sensory loss and neuropathic pain. DSP occurs in up to 7-35% of HIV1-infected individuals and upwards of 34% of children infected with HIV1, while ATN develops following highly active antiretroviral therapy (HAART) treatment in up to 52% of patients. The mechanisms of HIV-SN remain unclear; however, the advent of several models of HIV1-associated peripheral neuropathy is helping unlock the mysteries surrounding HIV-SN. This chapter describes the known pathology of HIV1 and the resulting neuropathy syndromes, including descriptions of the models used to study this particular type of neuropathic pain.
C1 [Bhangoo, Sonia K.] Natl Inst Dent & Craniofacial Res, Lab Sensory Biol, NIH, Bethesda, MD USA.
[Petty, Lauren; White, Fletcher A.] Indiana Univ, Sch Med, Dept Anesthesia, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA.
RP Bhangoo, SK (reprint author), Natl Inst Dent & Craniofacial Res, Lab Sensory Biol, NIH, Bethesda, MD USA.
RI White, Fletcher/F-3203-2015
OI White, Fletcher/0000-0002-8408-9262
NR 29
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 0893-2336
BN 978-1-60761-879-9
J9 NEUROMETHODS
JI Neuromethods
PY 2011
VL 49
BP 171
EP 179
DI 10.1007/978-1-60761-880-5_10
D2 10.1007/978-1-60761-880-5
PG 9
WC Cell Biology; Neurosciences
SC Cell Biology; Neurosciences & Neurology
GA BRN76
UT WOS:000283201100010
ER
PT B
AU Gottesman, S
AF Gottesman, Susan
BE Storz, G
Hengge, R
TI Roles of mRNA Stability, Translational Regulation, and Small RNAs in
Stress Response Regulation
SO BACTERIAL STRESS RESPONSES, 2ND EDITION
LA English
DT Article; Book Chapter
ID SMALL NONCODING RNAS; PSEUDOMONAS-FLUORESCENS CHA0;
STAPHYLOCOCCUS-AUREUS RNAIII; OUTER-MEMBRANE PROTEINS; ESCHERICHIA-COLI
HFQ; BACTERIAL SMALL RNA; GENE-EXPRESSION; DSRA RNA; DEPENDENT
REGULATION; ANTISENSE MECHANISM
AB Bacteria use every possible level of regulation for rapid response to stress and rapid readjustment after adaptation. The important roles that regulation of mRNA stability and translation play have only been fully recognized in the past 15 years. Regulatory mechanisms such as attenuation have been known for many years to affect mRNA folding, leading to changes in transcription termination under specific conditions; now small molecule effectors have been found to also lead to changes in folding of 5' untranslated regions (UTRs), affecting termination and translation (riboswitches). In Escherichia. coli, a variety of small regulatory RNAs have been found the majority of these regulate at the level of the mRNA. In many cases, the synthesis of these sRNAs is regulated as part of well-known global regulons. The largest class of sRNAs regulate mRNA stability and translation by pairing with specific target mRNAs. Efficient pairing requires the RNA chaperone Hfq. Other regulatory RNAs act to modulate the activity of translational regulators. Yet others do not yet have defined activities. Approaches used to define sRNAs and their function in E. coli and Salmonella are being applied broadly to other microorganisms. The general conclusion is that many, and possibly all, stress responses will be regulated at the level of mRNA stability and activity, as well as at other levels.
C1 NCI, Mol Biol Lab, Bethesda, MD 20892 USA.
RP Gottesman, S (reprint author), NCI, Mol Biol Lab, Bldg 37, Bethesda, MD 20892 USA.
NR 113
TC 2
Z9 2
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-621-6
PY 2011
BP 59
EP 73
PG 15
WC Microbiology
SC Microbiology
GA BSJ67
UT WOS:000284726100005
ER
PT B
AU Makarova, KS
Daly, MJ
AF Makarova, Kira S.
Daly, Michael J.
BE Storz, G
Hengge, R
TI Comparative Genomics of Stress Response Systems in Deinococcus Bacteria
SO BACTERIAL STRESS RESPONSES, 2ND EDITION
LA English
DT Article; Book Chapter
ID DOUBLE-STRAND BREAKS; ESCHERICHIA-COLI; IONIZING-RADIATION; EXTREME
RADIORESISTANCE; GAMMA-RADIATION; RADIODURANS R1; DNA-POLYMERASE;
HYDROGEN-PEROXIDE; RESISTANT MUTANTS; SP-NOV.
AB Bacteria of the genus Deinococcus represent life's outer limits for the bounds of radiation and desiccation resistance. Using a comparative genomic approach, we investigated the genetic determinants of these extremophilic traits in Deinococcus radiodurans, Deinococcus geothermalis, and Deinococcus deserti. Within this group, common evolutionary trends and a putative radiation response regulon were identified. Viewed from this perspective, contemporary hypotheses of extreme resistance are evaluated in this chapter : Arguments are presented that support that the Deinococcus lineage emerged progressively by amassing enzymatic and nonenzymatic cell-cleaning systems, but not by acquisition of novel DNA repair systems.
C1 [Makarova, Kira S.] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
[Daly, Michael J.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA.
RP Makarova, KS (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, 8600 Rockville Pike, Bethesda, MD 20894 USA.
NR 93
TC 1
Z9 1
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-621-6
PY 2011
BP 445
EP 457
PG 13
WC Microbiology
SC Microbiology
GA BSJ67
UT WOS:000284726100027
ER
PT S
AU Chen, GA
Henter, ID
Manji, HK
AF Chen, Guang
Henter, Ioline D.
Manji, Husseini K.
BE Manji, HK
Zarate, CA
TI Partial Rodent Genetic Models for Bipolar Disorder
SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
SE Current Topics in Behavioral Neurosciences
LA English
DT Article; Book Chapter
DE Bipolar disorder; Mania; Depression; Antidepressants; Mood stabilizers;
p11; Vesicular monoamine transporter 2 (VMAT2); Neural cell adhesion
molecule (NCAM); Extracellular signal-regulated kinase (ERK); Glutamate
receptor 6 (GluR6); Glucocorticoid receptor (GR); B-cell lymphoma 2
(Bcl-2); Bcl-2 associated athanogene (BAG1)
ID ANIMAL-MODELS; GLUCOCORTICOID-RECEPTOR; MOOD DISORDERS; MICE LACKING;
MUTANT MICE; BEHAVIORAL SENSITIZATION; ANTIDEPRESSANT TREATMENT; MAP
KINASE; CLOCK GENE; DEPRESSION
AB Bipolar disorder (BPD) is a complex clinical phenomenon This episodic illness comprises at least four features/components depression, mania vulnerability to mood swings in euthymic BPD patients, and spontaneous cyclicity in at least some BPD patients Currently, there is no rodent genetic model capable of encompassing the whole phenotype of BPD exists, however, recent genetic-behavioral studies have delineated partial models for some components of BPD, namely, depression, mania, and vulnerability or resilience to mood swings p11 knockout (KO), vesicular monoamine transporter 2 (VMAT2) heterozygous KO, and neural cell adhesion molecule (NCAM) KO mice display anhedonia-like symptoms, and treatment with antidepressants rescues this anhedonia-related phenotype Mutant CLOCK, glutamate receptor 6 (GluR6) KO, and extracellular signal-regulated kinase 1 (ERK1) KO mice exhibit mania-like behavioral clusters referred to as excessive behavioral excitement, at least some of the exhibited behaviors can be rescued through treatment with mood stabilizers or atypical antipsychotics Neuronal glucocorticoid receptor (GR) overexpressing, B-cell lymphoma 2 (Bcl-2) heterozygous KO, and Bcl-2-associated athanogene (BAG1) heterozygous KO mice show vulnerability to mood swings In contrast, neuronal BAG1 overexpressing mice display resilience to mood swings These mutant mouse strains and the behavioral approaches used to characterize these strains offer an emerging set of research tools for the comprehensive understanding of various components of BPD, and the interrelation of these components at the molecular, cellular, and neuronal circuitry levels These partial genetic models can also be used as complementary tools to augment other existing behavioral tests and paradigms in drug development for BPD
C1 [Chen, Guang; Henter, Ioline D.] NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
[Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA.
RP Chen, GA (reprint author), NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bldg 35 Rm 1C912 35 Convent Dr, Bethesda, MD 20892 USA.
RI Chen, Guang/A-2570-2017
FU Intramural NIH HHS [Z99 MH999999]
NR 71
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1866-3370
BN 978-3-642-15756-1
J9 CURR TOP BEHAV NEURO
JI Cur. Top. Behav. Neurosci.
PY 2011
VL 5
BP 89
EP 106
DI 10.1007/7854_2010_63
D2 10.1007/978-3-642-15757-8
PG 18
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA BSM87
UT WOS:000284977600006
PM 25236551
ER
PT S
AU Du, J
Machado-Vieira, R
Khairova, R
AF Du, Jing
Machado-Vieira, Rodrigo
Khairova, Rushaniya
BE Manji, HK
Zarate, CA
TI Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar
Disorder
SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
SE Current Topics in Behavioral Neurosciences
LA English
DT Article; Book Chapter
DE BDNF; Bipolar disorder; Cytokine; Mood stabilizer; Stress; Synaptic
plasticity
ID LONG-TERM POTENTIATION; AMPA-RECEPTOR TRAFFICKING; RAT HIPPOCAMPAL
SLICES; SUBGENUAL PREFRONTAL CORTEX; MAJOR DEPRESSIVE DISORDER;
NECROSIS-FACTOR-ALPHA; FORCED SWIM TEST; GLIAL TNF-ALPHA; DENTATE GYRUS;
MOOD DISORDERS
AB Emerging evidence suggests that synaptic plasticity is intimately involved in the pathophysiology and treatment of bipolar disorder (BPD) Under certain conditions, over-strengthened and/or weakened synapses at different circuits in the brain could disturb brain functions in parallel, causing manic-like or depressive-like behaviors in animal models In this chapter, we summarize the regulation of synaptic plasticity by medications, psychological conditions, hormones, and neurotrophic factors, and their correlation with mood-associated animal behaviors We conclude that increased serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (BDNF), acute corticosterone, and antidepressant treatments lead to enhanced synaptic strength in the hippocampus and also correlate with antidepressant-like behaviors In contrast, inhibiting monoaminergic signaling, long-term stress, and pathophysiological concentrations of cytokines weakens glutamatergic synaptic strength in the hippocampus and is associated with depressive-like symptoms
C1 [Du, Jing; Machado-Vieira, Rodrigo; Khairova, Rushaniya] NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
[Machado-Vieira, Rodrigo] NIMH, Expt Therapeut Mood & Anxiety Disorders Res Progr, NIH, Mark O Hatfield CRC, Bethesda, MD 20892 USA.
[Machado-Vieira, Rodrigo] Univ Sao Paulo, LIM Inst Psychiat, Sao Paulo, Brazil.
RP Du, J (reprint author), NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, 9000 Rockville Pike Bldg 35 1BC909, Bethesda, MD 20892 USA.
RI MACHADO-VIEIRA, RODRIGO/D-8293-2012
OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190
NR 147
TC 2
Z9 2
U1 2
U2 7
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1866-3370
BN 978-3-642-15756-1
J9 CURR TOP BEHAV NEURO
JI Cur. Top. Behav. Neurosci.
PY 2011
VL 5
BP 167
EP 185
DI 10.1007/7854_2010_65
D2 10.1007/978-3-642-15757-8
PG 19
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA BSM87
UT WOS:000284977600010
PM 25236555
ER
PT S
AU Machado-Vieira, R
Manji, HK
Zarate, CA
AF Machado-Vieira, Rodrigo
Manji, Husseini K.
Zarate, Carlos A., Jr.
BE Manji, HK
Zarate, CA
TI Potential Novel Therapeutics for Bipolar Disorders
SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
SE Current Topics in Behavioral Neurosciences
LA English
DT Article; Book Chapter
DE Bipolar disorder; Depression; Mania; Targets; Treatment
ID PROTEIN-KINASE-C; MAJOR DEPRESSIVE DISORDER; PLACEBO-CONTROLLED TRIAL;
FORCED SWIMMING TEST; AGOMELATINE ADJUNCTIVE THERAPY; LEARNED
HELPLESSNESS PARADIGM; GLYCOGEN-SYNTHASE KINASE-3;
OPIOID-RECEPTOR-AGONIST; OPEN-LABEL TRIAL; MOOD DISORDERS
AB Existing pharmacological treatments for bipolar disorder (BPD), a severe recurrent mood disorder, are in general insufficient for many patients Despite adequate doses and treatment duration many individuals with this disease continue to experience mood episode relapses, residual symptoms, and functional impairment This chapter reviews a number of targets/compounds that could result in putative novel treatments for BPD, including the dynorphin opioid neuropeptide system, the glutamatergic system, the purinergic system, the cholinergic system (muscarinic and nicotinic systems), the oxidative stress system, and the melatonergic system The arachidonic acid cascade and intracellular signaling cascades (including glycogen synthase kinase 3 and protein kinase C) are also reviewed, as are agents that affect multiple targets (e g, modafinil, Undine RG2417) Further study of these and similar agents may improve our understanding of relevant drug targets and their clinical utility as potential therapeutics for this devastating disorder
C1 [Zarate, Carlos A., Jr.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA.
[Machado-Vieira, Rodrigo] NIMH, Expt Therapeut Mood & Anxiety Disorders Res Progr, NIH, Mark O Hatfield CRC, Bethesda, MD 20892 USA.
[Machado-Vieira, Rodrigo] Univ Sao Paulo, LIM Inst Psychiat, BR-05508 Sao Paulo, Brazil.
[Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA.
[Machado-Vieira, Rodrigo] NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
RP Zarate, CA (reprint author), NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, 10 Ctr Dr,Unit 7 SE,Rm 7 3465, Bethesda, MD 20892 USA.
RI MACHADO-VIEIRA, RODRIGO/D-8293-2012
OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190
NR 178
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1866-3370
BN 978-3-642-15756-1
J9 CURR TOP BEHAV NEURO
JI Cur. Top. Behav. Neurosci.
PY 2011
VL 5
BP 303
EP 329
DI 10.1007/7854_2010_51
D2 10.1007/978-3-642-15757-8
PG 27
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA BSM87
UT WOS:000284977600017
PM 25236562
ER
PT S
AU Manji, HK
Henter, ID
Zarate, CA
AF Manji, Husseini K.
Henter, Ioline D.
Zarate, Carlos A., Jr.
BE Manji, HK
Zarate, CA
TI Bipolar Disorder: A Neurobiological Synthesis
SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
SE Current Topics in Behavioral Neurosciences
LA English
DT Article; Book Chapter
ID SCHIZOPHRENIA; PLASTICITY; PATHWAYS
C1 [Zarate, Carlos A., Jr.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA.
[Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA.
[Henter, Ioline D.] NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
RP Zarate, CA (reprint author), NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, 10 Ctr Dr Unit 7 SE Rm 7 3465, Bethesda, MD 20892 USA.
FU Intramural NIH HHS [Z99 MH999999]
NR 18
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1866-3370
BN 978-3-642-15756-1
J9 CURR TOP BEHAV NEURO
JI Cur. Top. Behav. Neurosci.
PY 2011
VL 5
BP 331
EP 340
DI 10.1007/7854_2010_98
D2 10.1007/978-3-642-15757-8
PG 10
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA BSM87
UT WOS:000284977600018
PM 25236563
ER
PT B
AU Palmer, RJ
Darveau, R
Lamont, RJ
Nyvad, B
Teles, RP
AF Palmer, Robert J., Jr.
Darveau, Richard
Lamont, Richard J.
Nyvad, Bente
Teles, Ricardo P.
BE Bjarnsholt, T
Moser, C
Jensen, PO
Hoiby, N
TI Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis
SO BIOFILM INFECTIONS
LA English
DT Article; Book Chapter
ID HUMAN PERIODONTAL POCKETS; LIPOPOLYSACCHARIDE-BINDING PROTEIN; EARLY
MICROBIAL COLONIZATION; DISEASE-ASSOCIATED BACTERIA; ADHESION MOLECULE-1
ELAM-1; HUMAN GINGIVAL FIBROBLASTS; HUMAN SUBGINGIVAL PLAQUE;
MEMBRANE-BOUND CD14; SURFACES IN-VIVO; PORPHYROMONAS-GINGIVALIS
C1 [Palmer, Robert J., Jr.] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD USA.
[Darveau, Richard] Univ Washington, Dept Periodont, Seattle, WA 98195 USA.
[Lamont, Richard J.] Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA.
[Nyvad, Bente] Univ Aarhus, Fac Hlth Sci, Sch Dent, Aarhus, Denmark.
[Teles, Ricardo P.] Forsyth Inst, Dept Periodontol, Boston, MA USA.
RP Palmer, RJ (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD USA.
EM rjpalmer@dir.nidcr.nih.gov
NR 163
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6083-2
PY 2011
BP 35
EP 68
DI 10.1007/978-1-4419-6084-9_4
D2 10.1007/978-1-4419-6084-9
PG 34
WC Microbiology
SC Microbiology
GA BSC47
UT WOS:000284120900004
ER
PT S
AU Fraley, SI
Hale, CM
Bloom, RJ
Celedon, A
Lee, JSH
Wirtz, D
AF Fraley, Stephanie I.
Hale, Christopher M.
Bloom, Ryan J.
Celedon, Alfredo
Lee, Jerry S. H.
Wirtz, Denis
BE Gerecht, S
TI Intra- and Extracellular Microrheology of Endothelial Cells in a 3D
Matrix
SO BIOPHYSICAL REGULATION OF VASCULAR DIFFERENTIATION AND ASSEMBLY
SE Biological and Medical Physics Biomedical Engineering
LA English
DT Article; Book Chapter
ID PARTICLE-TRACKING MICRORHEOLOGY; BALLISTIC INTRACELLULAR NANORHEOLOGY;
ANGIOGENESIS IN-VITRO; RHO-KINASE; ACTIN-FILAMENTS; PROTEIN-KINASE;
LIVING CELLS; TUMOR-CELLS; MIGRATION; NUCLEUS
C1 [Fraley, Stephanie I.; Hale, Christopher M.; Bloom, Ryan J.; Lee, Jerry S. H.; Wirtz, Denis] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.
[Fraley, Stephanie I.; Hale, Christopher M.; Celedon, Alfredo; Wirtz, Denis] Johns Hopkins Univ, Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD 21218 USA.
[Celedon, Alfredo] Pontificia Univ Catolica Chile, Dept Mech Engn, Santiago 6904411, Chile.
[Lee, Jerry S. H.] NCI, Ctr Strateg Sci Initiat, Off Director, NIH, Bethesda, MD 20892 USA.
RP Wirtz, D (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.
EM wirtz@jhu.edu
NR 61
TC 1
Z9 1
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 1618-7210
BN 978-1-4419-7834-9
J9 BIOL MED PHYS BIOMED
JI Biol. Med. Phys. Biomed. Eng.
PY 2011
BP 69
EP 87
DI 10.1007/978-1-4419-7835-6_4
D2 10.1007/978-1-4419-7835-6
PG 19
WC Biology; Biophysics; Developmental Biology
SC Life Sciences & Biomedicine - Other Topics; Biophysics; Developmental
Biology
GA BTE36
UT WOS:000286639000004
ER
PT S
AU Finzi, L
Manzo, C
Zurla, C
Wang, HW
Lewis, D
Adhya, S
Dunlap, D
AF Finzi, Laura
Manzo, Carlo
Zurla, Chiara
Wang, Haowei
Lewis, Dale
Adhya, Sankar
Dunlap, David
BE Williams, MC
Maher, LJ
TI DNA Looping in Prophage Lambda: New Insight from Single-Molecule
Microscopy
SO BIOPHYSICS OF DNA- PROTEIN INTERACTIONS: FROM SINGLE MOLECULES TO
BIOLOGICAL SYSTEMS
SE Biological and Medical Physics Biomedical Engineering
LA English
DT Article; Book Chapter
ID TETHERED PARTICLE MOTION; ION-CHANNEL KINETICS; COOPERATIVE OPERATOR
BINDING; BACTERIOPHAGE-LAMBDA; GENE-REGULATION; TRANSCRIPTION
ACTIVATION; CRYSTAL-STRUCTURE; CI REPRESSOR; PHAGE-LAMBDA; MODEL
C1 [Finzi, Laura; Dunlap, David] Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA.
[Finzi, Laura] Emory Univ, Dept Phys, Atlanta, GA 30322 USA.
[Manzo, Carlo] Inst Bioengn Catalonia, Barcelona, Spain.
[Zurla, Chiara] Georgia Inst Technol, Dept Bioengn, Atlanta, GA 30332 USA.
[Wang, Haowei] Georgia Inst Technol, Dept Phys, Atlanta, GA 30322 USA.
[Lewis, Dale; Adhya, Sankar] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Finzi, L (reprint author), Emory Univ, Dept Cell Biol, 615 Michael St, Atlanta, GA 30322 USA.
EM lfinzi@physics.emory.edu
RI Manzo, Carlo/B-9745-2012
OI Manzo, Carlo/0000-0002-8625-0996
NR 50
TC 2
Z9 2
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 1618-7210
BN 978-0-387-92807-4
J9 BIOL MED PHYS BIOMED
JI Biol. Med. Phys. Biomed. Eng.
PY 2011
BP 193
EP 212
DI 10.1007/978-0-387-92808-1_9
D2 10.1007/978-0-387-92808-1
PG 20
WC Biology; Biophysics; Engineering, Biomedical
SC Life Sciences & Biomedicine - Other Topics; Biophysics; Engineering
GA BRS06
UT WOS:000283519500009
ER
PT B
AU Asagoshi, K
Wilson, SH
AF Asagoshi, Kenjiro
Wilson, Samuel H.
BE Penning, TM
TI Base-Excision Repair: Role of DNA Polymerase beta in Late-Stage Base
Excision Repair
SO CHEMICAL CARCINOGENESIS
SE Current Cancer Research
LA English
DT Article; Book Chapter
ID CELL NUCLEAR ANTIGEN; PHOSPHATE LYASE ACTIVITY; MAMMALIAN-CELLS; FLAP
ENDONUCLEASE-1; ABASIC SITES; IN-VITRO; INDUCED CYTOTOXICITY; PURIFIED
PROTEINS; OXIDATIVE STRESS; BOVINE TESTIS
AB The cellular DNA repair pathway known as base-excision repair is responsible for removing toxic base lesions and strand breaks from genomic and mitochondrial DNA. The base-excision repair pathway is conserved in organisms throughout nature, but there are many variations probably reflecting the broad range of genotoxic stresses encountered and the gene expression status of the organism. There has been remarkable progress in recent years toward deciphering the various types of base lesions and the multiple steps and subpathways involved in the overall base excision pathway. This progress is reviewed here, and a detailed discussion of current research on the long-patch base-excision repair subpathway is presented.
C1 [Asagoshi, Kenjiro; Wilson, Samuel H.] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Wilson, SH (reprint author), NIEHS, Struct Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM kenjiro_asagoshi@med.unc.edu; wilson5@niehs.nih.gov
NR 82
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-61737-994-9
J9 CURR CANCER RES
PY 2011
BP 297
EP 319
DI 10.1007/978-1-61737-995-6_14
D2 10.1007/978-1-61737-995-6
PG 23
WC Oncology; Pharmacology & Pharmacy
SC Oncology; Pharmacology & Pharmacy
GA BUD31
UT WOS:000288919300014
ER
PT S
AU Solomon, BD
Collmann, H
Kress, W
Muenke, M
AF Solomon, B. D.
Collmann, H.
Kress, W.
Muenke, M.
BE Muenke, M
Kress, W
Collmann, H
Solomon, BD
TI Craniosynostosis: A Historical Overview
SO CRANIOSYNOSTOSES: MOLECULAR GENETICS, PRINCIPLES OF DIAGNOSIS, AND
TREATMENT
SE Monographs in Human Genetics
LA English
DT Article; Book Chapter
ID SAETHRE-CHOTZEN SYNDROME; PFEIFFER-SYNDROME; CROUZON-SYNDROME; IDENTICAL
MUTATIONS; FGFR2; GENE; TWIST
AB Craniosynostosis has been recognized since ancient times, and the condition has a colorful and diverse history. In this introductory chapter, we include a description of historical aspects of craniosynostosis, which touches upon ancient depictions of the condition, the advent of modern classification schemes, more recent gene discoveries involving the molecular causes of many types of craniosynostosis, and evolving aspects of the management of affected patients. Copyright (C) 2011 S. Karger AG, Basel
C1 [Solomon, B. D.; Muenke, M.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
[Kress, W.] Univ Wurzburg, Inst Human Genet, D-8700 Wurzburg, Germany.
[Collmann, H.] Univ Wurzburg, Dept Neurosurg, D-8700 Wurzburg, Germany.
RP Muenke, M (reprint author), NHGRI, Med Genet Branch, NIH, MSC 3717,Bldg 35,Room 1B-203, Bethesda, MD 20892 USA.
EM mamuenke@mail.nih.gov; mamuenke@mail.nih.gov
NR 33
TC 0
Z9 1
U1 0
U2 0
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0077-0876
BN 978-3-8055-9595-7
J9 MONOGR HUM GENET
JI Monogr. Hum. Genet.
PY 2011
VL 19
BP 1
EP 7
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA BUD41
UT WOS:000288923200001
ER
PT S
AU Collmann, H
Solomon, BD
Schweitzer, T
Kress, W
Muenke, M
AF Collmann, H.
Solomon, B. D.
Schweitzer, T.
Kress, W.
Muenke, M.
BE Muenke, M
Kress, W
Collmann, H
Solomon, BD
TI Nonsyndromic Craniosynostoses
SO CRANIOSYNOSTOSES: MOLECULAR GENETICS, PRINCIPLES OF DIAGNOSIS, AND
TREATMENT
SE Monographs in Human Genetics
LA English
DT Article; Book Chapter
ID SINGLE-SUTURE CRANIOSYNOSTOSIS; SAGITTAL SYNOSTOSIS; CORONAL SYNOSTOSIS;
METOPIC SYNOSTOSIS; LARGE COHORT; MUTATIONS; GENES; TWINS; MANAGEMENT;
PHENOTYPE
AB The subtypes of nonsyndromic ('isolated') craniosynostosis are denominated according to the predominant deformity resulting from premature fusion of one of the major cranial sutures: scaphocephaly, trigonocephaly, anterior plagiocephaly, brachycephaly, posterior plagiocephaly, and oxycephaly. In most cases the underlying causes remain unknown although there is some overlap with syndromic craniosynostosis suggesting heterogeneous etiologies. In contrast to the oversimplified nomenclature, isolated craniosynostosis may involve two or more sutures at the same time or may progress with increasing age, thus indicating that the basic nature of craniosynostosis is a failure of growth regulation of the skull rather than a malformation. Copyright (C) 2011 S. Karger AG, Basel
C1 [Collmann, H.; Schweitzer, T.] Univ Wurzburg, Dept Pedriatr Neurosurg, Sect Pediat Neurosurg, D-97074 Wurzburg, Germany.
[Solomon, B. D.; Muenke, M.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
[Kress, W.] Univ Wurzburg, Inst Human Genet, D-97074 Wurzburg, Germany.
RP Collmann, H (reprint author), Univ Wurzburg, Dept Pedriatr Neurosurg, Sect Pediat Neurosurg, Josef Schneider Str 2, D-97074 Wurzburg, Germany.
EM collmann.h@nch.uni-wuerzburg.de; collmann.h@nch.uni-wuerzburg.de
RI Schweitzer, Tilmann/K-6471-2014
NR 52
TC 1
Z9 1
U1 0
U2 0
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0077-0876
BN 978-3-8055-9595-7
J9 MONOGR HUM GENET
JI Monogr. Hum. Genet.
PY 2011
VL 19
BP 165
EP 176
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA BUD41
UT WOS:000288923200014
ER
PT B
AU Hsueh, YP
Lin, XR
Kwon-Chung, KJ
Heitman, J
AF Hsueh, Yen-Ping
Lin, Xiaorong
Kwon-Chung, Kyung J.
Heitman, Joseph
BE Heitman, J
Kozel, TR
KwonChung, KJ
Perfect, JR
Casadevall, A
TI Sexual Reproduction of Cryptococcus
SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST
LA English
DT Article; Book Chapter
ID FUNGAL PATHOGEN CRYPTOCOCCUS; PROTEIN-COUPLED RECEPTORS;
HOMOBASIDIOMYCETE SCHIZOPHYLLUM-COMMUNE; NEOFORMANS VAR. GRUBII;
ALPHA-FACTOR RECEPTOR; MANURE FILTRATE AGAR; MATING-TYPE LOCUS;
FILOBASIDIELLA-NEOFORMANS; PHEROMONE RECEPTOR; SACCHAROMYCES-CEREVISIAE
C1 [Hsueh, Yen-Ping] CALTECH, Div Biol, Pasadena, CA 91125 USA.
[Heitman, Joseph] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA.
[Lin, Xiaorong] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA.
[Kwon-Chung, Kyung J.] NIAID, Mol Microbiol Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Hsueh, YP (reprint author), CALTECH, Div Biol, Pasadena, CA 91125 USA.
NR 175
TC 3
Z9 3
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-501-1
PY 2011
BP 81
EP 96
PG 16
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA BSJ71
UT WOS:000284727500007
ER
PT B
AU Idnurm, A
Williamson, PR
AF Idnurm, Alexander
Williamson, Peter R.
BE Heitman, J
Kozel, TR
KwonChung, KJ
Perfect, JR
Casadevall, A
TI Genetic and Genomic Approaches to Cryptococcus Environmental and Host
Responses
SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST
LA English
DT Article; Book Chapter
ID ORGAN TRANSPLANT RECIPIENTS; NEOFORMANS VAR. GRUBII;
CENTRAL-NERVOUS-SYSTEM; MATING-TYPE LOCUS; A MATA STRAIN;
AGROBACTERIUM-TUMEFACIENS; INSERTIONAL MUTAGENESIS; SIGNALING PATHWAY;
BINDING-PROTEIN; VIRULENCE GENES
C1 [Idnurm, Alexander] Univ Missouri, Div Cell Biol & Biophys, Sch Biol Sci, Kansas City, MO 64110 USA.
[Williamson, Peter R.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Idnurm, A (reprint author), Univ Missouri, Div Cell Biol & Biophys, Sch Biol Sci, 5100 Rockhill Rd, Kansas City, MO 64110 USA.
NR 72
TC 1
Z9 1
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-501-1
PY 2011
BP 127
EP 137
PG 11
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA BSJ71
UT WOS:000284727500010
ER
PT B
AU Nielsen, K
Kwon-Chung, KJ
AF Nielsen, Kirsten
Kwon-Chung, Kyung J.
BE Heitman, J
Kozel, TR
KwonChung, KJ
Perfect, JR
Casadevall, A
TI A Role for Mating in Cryptococcal Virulence
SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST
LA English
DT Article; Book Chapter
ID FUNGAL PATHOGEN CRYPTOCOCCUS; NEOFORMANS SEROTYPE-A; BRITISH-COLUMBIA;
VANCOUVER-ISLAND; SEXUAL CYCLE; FILOBASIDIELLA-NEOFORMANS; ANTIOXIDANT
DEFENSE; TUP1 DISRUPTION; ALPHA-STRAINS; MATA STRAIN
C1 [Nielsen, Kirsten] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA.
[Kwon-Chung, Kyung J.] NIAID, Mol Microbiol Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RP Nielsen, K (reprint author), Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA.
NR 88
TC 2
Z9 2
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-501-1
PY 2011
BP 167
EP +
PG 9
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA BSJ71
UT WOS:000284727500013
ER
PT S
AU Kanungo, J
Zheng, YL
Rudrabhatla, P
Amin, ND
Mishra, B
Pant, HC
AF Kanungo, Jyotshnabala
Zheng, Ya-li
Rudrabhatla, Parvathi
Amin, Niranjana D.
Mishra, Bibhutibhushan
Pant, Harish C.
BE Nixon, RA
Yuan, A
TI Deregulation of Cytoskeletal Protein Phosphorylation and
Neurodegeneration
SO CYTOSKELETON OF THE NERVOUS SYSTEM
SE Advances in Neurobiology
LA English
DT Article; Book Chapter
DE AD; ALS; Neurodegeneration; Neurofilament; Phosphorylation;
Proline-directed kinases; Tau
ID CYCLIN-DEPENDENT KINASE-5; AMYOTROPHIC-LATERAL-SCLEROSIS; PAIRED HELICAL
FILAMENTS; WEIGHT NEUROFILAMENT PROTEIN; NEURONAL INTERMEDIATE
FILAMENTS; MICROTUBULE-ASSOCIATED PROTEINS; GLYCOGEN-SYNTHASE KINASE-3;
FETAL-TYPE PHOSPHORYLATION; ALZHEIMERS-DISEASE; TAU-PROTEIN
AB Phosphorylation of cytoskeletal proteins is tightly regulated by the activities of multiple protein kinases and phosphatases. Three kinases, Cyclin-dependent kinase 5 (Cdk5), Glycogen synthase kinase 3 beta (GSK3 beta) and MAPKs have been implicated in their direct involvement in neuronal cytoskeletal protein phosphorylation. Cdk5 and GSK3 beta have been identified as prime candidates for pathogenesis. Cdk5 is a proline-directed serine/threonine protein kinase that requires an interaction with its activators, p35 or p39, to be catalytically active. While Cdk5 expression is ubiquitous, p35 and p39 are abundantly expressed in postmitotic neurons which, therefore, exhibit enhanced levels of Cdk5 activity. A pleiotropic kinase, Cdk5 has a multifunctional role in the mammalian central nervous system. Cdk5 was originally identified as a major Tau kinase. It associates with early stages of neurofibrillary tangles (NFTs). NFTs are composed mainly of hyperphosphorylated Tau aggregates, the pathological hallmarks of neurodegenerative tauopathies and Alzheimer's disease (AD). Cdk5, by phosphorylating neuronal cytoskeletal proteins, such as Tau and neurofilaments (NFs), plays a critical role in neurodegeneration. In this review, we focus on the specific roles of Cdk5 phosphorylation of the neuronal cytoskeletal proteins (NFs and Tau) that contribute to neurodegeneration.
C1 [Kanungo, Jyotshnabala; Zheng, Ya-li; Rudrabhatla, Parvathi; Amin, Niranjana D.; Pant, Harish C.] Natl Inst Neurol Disorders & Stroke, Neurochem Lab, NIH, Bethesda, MD 20892 USA.
[Mishra, Bibhutibhushan] Georgetown Univ, Sch Med, Dev Neurobiol Lab, Washington, DC 20007 USA.
RP Pant, HC (reprint author), Natl Inst Neurol Disorders & Stroke, Neurochem Lab, NIH, Bethesda, MD 20892 USA.
EM kanungo@fda.hhs.gov; yalinew@yahoo.com; parvathir@ninds.nih.gov;
aminn@ninds.nih.gov; bm72@georgetown.edu; panth@ninds.nih.gov
NR 167
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 2190-5215
BN 978-1-4419-6786-2
J9 ADV NEUROBIOL
JI Adv. Neurobiol.
PY 2011
VL 3
BP 297
EP 324
DI 10.1007/978-1-4419-6787-9_14
D2 10.1007/978-1-4419-6787-9
PG 28
WC Biology; Neurosciences
SC Life Sciences & Biomedicine - Other Topics; Neurosciences & Neurology
GA BTS28
UT WOS:000287955100014
ER
PT B
AU Iozzo, RV
Goldoni, S
Berendsen, AD
Young, MF
AF Iozzo, Renato V.
Goldoni, Silvia
Berendsen, Agnes D.
Young, Marian F.
BE Mecham, RP
TI Small Leucine-Rich Proteoglycans
SO EXTRACELLULAR MATRIX: AN OVERVIEW
SE Biology of Extracellular Matrix
LA English
DT Article; Book Chapter
ID EPIDERMAL-GROWTH-FACTOR; DECORIN-DEFICIENT MICE; CHONDROITIN SULFATE
PROTEOGLYCAN; STATIONARY NIGHT BLINDNESS; ABNORMAL COLLAGEN FIBRILS;
CYCLIN-DEPENDENT KINASES; NECROSIS-FACTOR-ALPHA; COMPLETE CDNA CLONING;
HUMAN COLON-CARCINOMA; SMOOTH-MUSCLE-CELLS
AB The small leucine-rich proteoglycans (SLRPs) comprise an expanding family of proteoglycans and glycoproteins that now encompass five distinct groups including three canonical and two noncanonical classes based on shared structural and functional parameters. SLRPs are tissue organizers by orienting and ordering various collagenous matrices during ontogeny, wound repair, and cancer and interact with a number of surface receptors and growth factors, thereby regulating cell behavior. The focus of this chapter is on novel conceptual and functional advances in our understanding of SLRP biology with special emphasis on genetic diseases, cancer growth, fibrosis, osteoporosis, and other biological processes where these proteoglycans play a central role.
C1 [Iozzo, Renato V.; Goldoni, Silvia] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA.
[Iozzo, Renato V.; Goldoni, Silvia] Thomas Jefferson Univ, Kimmel Canc Ctr, Canc Cell Biol & Signaling Program, Philadelphia, PA 19107 USA.
[Berendsen, Agnes D.; Young, Marian F.] NIDCR, Craniofacial & Skeletal Dis Branch, Mol Biol Bones & Teeth Sect, NIH, Bethesda, MD 20892 USA.
RP Iozzo, RV (reprint author), Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Room 249 JAH,1020 Locust St, Philadelphia, PA 19107 USA.
EM iozzo@mail.jci.tju.edu
NR 197
TC 25
Z9 25
U1 0
U2 3
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16554-2
J9 BIOL EXTRACELL MATR
PY 2011
BP 197
EP 231
DI 10.1007/978-3-642-16555-9_6
D2 10.1007/978-3-642-16555-9
PG 35
WC Cell Biology
SC Cell Biology
GA BTW03
UT WOS:000288227100006
ER
PT B
AU Roberts, DD
Lau, LF
AF Roberts, David D.
Lau, Lester F.
BE Mecham, RP
TI Matricellular Proteins
SO EXTRACELLULAR MATRIX: AN OVERVIEW
SE Biology of Extracellular Matrix
LA English
DT Article; Book Chapter
ID TISSUE-GROWTH-FACTOR; OLIGOMERIC MATRIX PROTEIN; SINGLE-NUCLEOTIDE
POLYMORPHISMS; ENDOTHELIAL-CELL PROLIFERATION; THROMBOSPONDIN TYPE-1
REPEATS; SMOOTH-MUSCLE-CELLS; PROGRESSIVE PSEUDORHEUMATOID DYSPLASIA;
ANGIOGENESIS INHIBITOR ABT-510; ISCHEMIA-REPERFUSION INJURY; MOUSE
EMBRYONIC-DEVELOPMENT
AB In addition to its major structural elements, extracellular matrix contains a number of factors that are important for orchestrating developmental morphogenesis, maintaining tissue homeostasis in adults, and regenerating tissue following injury. Several proteins that serve these functions share a complex modular structure that enables them to interact with specific components of the matrix while engaging specific cell surface receptors through which they control cell behavior. These have been named matricellular proteins. Matricellular proteins, including the thrombospondins, some thrombospondin-repeat superfamily members, tenascins, SPARC, CCN proteins, and SIBLING proteins, are increasingly recognized to play important roles in inherited disorders, responses to injury and stress, and the pathogenesis of several chronic diseases of aging. Improved understanding of the functions and mechanisms of action of matricellular proteins is beginning to yield novel therapeutic strategies for prevention or treatment of these diseases.
C1 [Roberts, David D.] NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Lau, Lester F.] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA.
RP Roberts, DD (reprint author), NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
EM droberts@helix.nih.gov; LFLau@uic.edu
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
NR 298
TC 3
Z9 3
U1 0
U2 4
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-3-642-16554-2
J9 BIOL EXTRACELL MATR
PY 2011
BP 369
EP 413
DI 10.1007/978-3-642-16555-9_11
D2 10.1007/978-3-642-16555-9
PG 45
WC Cell Biology
SC Cell Biology
GA BTW03
UT WOS:000288227100011
ER
PT B
AU Kaufmann, SHE
Rouse, B
Sacks, D
AF Kaufmann, Stefan H. E.
Rouse, Barry
Sacks, David
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI The Immune Response to Infection: Introduction
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Editorial Material; Book Chapter
C1 [Kaufmann, Stefan H. E.] Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany.
[Rouse, Barry] Univ Tennessee, Dept Pathobiol, Knoxville, TN 37996 USA.
[Sacks, David] NIAID, Parasit Dis Lab, Intracellular Parasite Biol Sect, Bethesda, MD 20892 USA.
RP Kaufmann, SHE (reprint author), Max Planck Inst Infect Biol, Dept Immunol, Charitepl 1, D-10117 Berlin, Germany.
NR 4
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 1
EP 4
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300001
ER
PT B
AU Belkaid, Y
Sehrawat, S
Rouse, BT
AF Belkaid, Yasmine
Sehrawat, Sharvan
Rouse, Barry T.
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Regulation of Antimicrobial Immunity
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID T-HELPER TYPE-1; VIRAL-INDUCED IMMUNOPATHOLOGY; TRANSCRIPTION FACTOR
FOXP3; TGF-BETA; CELLS CONTROL; IMMUNOINFLAMMATORY LESIONS; PROTECTIVE
IMMUNITY; IL-2 PRODUCTION; IN-VIVO; INFECTION
C1 [Belkaid, Yasmine] NIH, Mucosal Immunol Unit, Parasit Dis Lab, Div Intramural Res, Bethesda, MD 20892 USA.
[Sehrawat, Sharvan; Rouse, Barry T.] Univ Tennessee, Coll Vet Med, Dept Pathobiol, Knoxville, TN 37996 USA.
RP Belkaid, Y (reprint author), NIH, Mucosal Immunol Unit, Parasit Dis Lab, Div Intramural Res, 4 Ctr Dr B1-28, Bethesda, MD 20892 USA.
NR 79
TC 1
Z9 1
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 109
EP 120
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300009
ER
PT B
AU Hunter, CA
Sher, A
AF Hunter, Christopher A.
Sher, Alan
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Innate Immunity to Parasitic Infections
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID NATURAL-KILLER-CELLS; COMPLEMENT REGULATORY PROTEIN; TRYPANOSOMA-CRUZI
INFECTION; TOXOPLASMA-GONDII INFECTION; MANNOSE-BINDING LECTIN;
GROWTH-FACTOR-BETA; HUMAN NK CELLS; DENDRITIC CELLS; LEISHMANIA-MAJOR;
ENTAMOEBA-HISTOLYTICA
C1 [Hunter, Christopher A.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.
[Sher, Alan] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Hunter, CA (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Rm 313,Hill Pavil,380 S Univ Ave, Philadelphia, PA 19104 USA.
NR 108
TC 0
Z9 0
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 225
EP 236
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300019
ER
PT B
AU Wynn, TA
Allen, JE
AF Wynn, Thomas A.
Allen, Judith E.
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Pathogenesis of Helminth Infections
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID ALTERNATIVELY ACTIVATED MACROPHAGES; SCHISTOSOMA-MANSONI EGGS;
ANTIGEN-PRESENTING CELLS; SYNTHASE ARGINASE BALANCE; NITRIC-OXIDE
PRODUCTION; CHITINASE-LIKE PROTEINS; NIPPOSTRONGYLUS-BRASILIENSIS;
MURINE SCHISTOSOMIASIS; PROTECTIVE IMMUNITY; BRUGIA-MALAYI
C1 [Wynn, Thomas A.] NIAID, Immunopathogenesis Sect, NIH, Bethesda, MD 20892 USA.
[Allen, Judith E.] Univ Edinburgh, Inst Evolut Immunol & Infect Res, Edinburgh EH9 3JT, Midlothian, Scotland.
RP Wynn, TA (reprint author), NIAID, Immunopathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 146
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 347
EP 359
PG 13
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300029
ER
PT B
AU Amaratunga, C
Lopera-Mesa, TM
Tse, JG
Mita-Mendoza, NK
Fairhurst, RM
AF Amaratunga, Chanaki
Lopera-Mesa, Tatiana M.
Tse, Jeanette G.
Mita-Mendoza, Neida K.
Fairhurst, Rick M.
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Pathology and Pathogenesis of Malaria
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID PLASMODIUM-FALCIPARUM MALARIA; HUMAN CEREBRAL MALARIA; RED-BLOOD-CELLS;
CAVEOLA-VESICLE COMPLEXES; PAPUA-NEW-GUINEA; VIVAX MALARIA; INFECTED
ERYTHROCYTES; HEMOGLOBIN-C; RESPIRATORY-DISTRESS; PARASITIZED
ERYTHROCYTES
C1 [Amaratunga, Chanaki; Lopera-Mesa, Tatiana M.; Tse, Jeanette G.; Mita-Mendoza, Neida K.; Fairhurst, Rick M.] NIAAA, Lab Malaria & Vector Res, Rockville, MD 20852 USA.
RP Amaratunga, C (reprint author), NIAAA, Lab Malaria & Vector Res, Rockville, MD 20852 USA.
NR 150
TC 0
Z9 0
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 361
EP 381
PG 21
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300030
ER
PT B
AU Graham, BS
Walker, C
AF Graham, Barney S.
Walker, Christopher
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Meeting the Challenge of Vaccine Design To Control HIV and Other
Difficult Viruses
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID HEPATITIS-C VIRUS; RESPIRATORY SYNCYTIAL VIRUS;
HUMAN-IMMUNODEFICIENCY-VIRUS; ADAPTIVE IMMUNE-RESPONSES; T-CELL
IMMUNITY; NEUTRALIZING ANTIBODIES; INFECTION; CHIMPANZEES; TRANSMISSION;
ESCAPE
C1 [Graham, Barney S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA.
[Walker, Christopher] Ohio State Univ, Nationwide Childrens Hosp, Columbus, OH 43205 USA.
[Walker, Christopher] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA.
[Walker, Christopher] Ohio State Univ, Dept Pathol, Columbus, OH 43205 USA.
[Walker, Christopher] Ohio State Univ, Dept Mol Virol, Columbus, OH 43205 USA.
RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 59
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 559
EP 570
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300045
ER
PT B
AU Long, CA
Zavala, FP
AF Long, Carole A.
Zavala, Fidel P.
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Immune Intervention in Malaria
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID PLASMODIUM-FALCIPARUM INFECTION; X-IRRADIATED SPOROZOITES; CD8+ T-CELLS;
CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; VACCINE DEVELOPMENT;
ACQUIRED-IMMUNITY; VIVAX MALARIA; IN-VITRO; SURFACE
C1 [Long, Carole A.] NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
[Zavala, Fidel P.] Johns Hopkins Univ, Dept Mol Microbiol & Immun, Bloomberg Sch Publ Hlth, Malaria Res Inst, Baltimore, MD 21205 USA.
RP Long, CA (reprint author), NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
NR 69
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 587
EP 597
PG 11
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300047
ER
PT B
AU McDowell, MA
Kamhawi, S
AF McDowell, Mary Ann
Kamhawi, Shaden
BE Kaufmann, SHE
Rouse, BT
Sacks, DL
TI Targeting Components in Vector Saliva
SO IMMUNE RESPONSE TO INFECTION
LA English
DT Article; Book Chapter
ID SAND FLY SALIVA; LUTZOMYIA-LONGIPALPIS COMPLEX; ANTI-MOSQUITO
ANTIBODIES; HOST IMMUNE-RESPONSE; LEISHMANIA-MAJOR; VISCERAL
LEISHMANIASIS; PLASMODIUM-BERGHEI; GLAND EXTRACTS; AEDES-AEGYPTI;
IMMUNOMODULATORY PROPERTIES
C1 [McDowell, Mary Ann] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth & Infect Dis, Notre Dame, IN 46556 USA.
[Kamhawi, Shaden] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
RP McDowell, MA (reprint author), Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth & Infect Dis, Notre Dame, IN 46556 USA.
NR 87
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-514-1
PY 2011
BP 599
EP 608
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA BSQ56
UT WOS:000285482300048
ER
PT B
AU Shanker, A
AF Shanker, Anil
BE Marincola, FM
Wang, E
TI The Immune Rejection: Lessons from Experimental Models
SO IMMUNOLOGIC SIGNATURES OF REJECTION
LA English
DT Article; Book Chapter
ID TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; REGULATORY T-CELLS;
ADIPOSE-TISSUE; INNATE IMMUNITY; IFN-GAMMA; PROTECTIVE IMMUNITY;
ANTITUMOR IMMUNITY; OBESITY; CHILDREN
AB The mechanisms of immune rejection depend on a complex interplay between the elements of innate and adaptive immunity. Several studies in animal models of cancer and other conditions, including obesity and intestinal microbiome, over the past decade have provided evidence for an intricate cross-regulation of innate resistance and adaptive immunity. More recently, it became apparent that adaptive immunity, besides its effector function, also controls innate immune responses beyond its role in immune complex-Fc receptor interaction. This has led to a paradigm shift from the classical unidirectional notion of the innate instruction of adaptive immunity to a bidirectional partnership of the innate and adaptive immune system in controlling various pathological and physiological conditions. This chapter summarizes the advances in our understanding of the mechanisms of immune reactivity in the models of intestinal microbiota, acute infections, obesity, and cancer.
C1 [Shanker, Anil] NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA.
[Shanker, Anil] SAIC Frederick Inc, Basic Sci Program, Frederick, MD USA.
RP Shanker, A (reprint author), NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA.
EM shankera@mail.nih.gov
OI Shanker, Anil/0000-0001-6372-3669
NR 45
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7218-7
PY 2011
BP 17
EP 25
DI 10.1007/978-1-4419-7219-4_3
D2 10.1007/978-1-4419-7219-4
PG 9
WC Oncology
SC Oncology
GA BSH95
UT WOS:000284503300003
ER
PT B
AU Wang, E
Marincola, FM
AF Wang, Ena
Marincola, Francesco M.
BE Marincola, FM
Wang, E
TI Immune-Mediated Tumor Rejection
SO IMMUNOLOGIC SIGNATURES OF REJECTION
LA English
DT Article; Book Chapter
ID POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; NATURAL-KILLER-CELLS;
SOLID-ORGAN TRANSPLANTATION; VERSUS-HOST-DISEASE; CLASS-I EXPRESSION;
CYTOTOXIC T-CELLS; C VIRUS-INFECTION; GENE-EXPRESSION; VACCINIA-VIRUS;
SPONTANEOUS REGRESSION
AB Fundamental strides in the understanding of the molecular basis of tumor rejection At were made in the last decade thanks to observational studies performed at relevant time points in human cancerous tissues. The following concepts emerged: immune surveillance against tumors is a likely occurrence. When cancer cells evolve to escape the ongoing immune defense, the neoplastic process reaches a clinically observable phase. By necessity, at this stage, escape mechanisms override anti-cancer mechanisms for tumors to be observable. When cancers become established, two molecular phenotypes can usually be observed: one is characterized by a tumor microenvironment infiltrated by immune cells bearing transcriptional signatures consistent with a status of partial activation. Although incapable of dramatically affecting tumor growth, immune infiltration bears a favorable prognostic and/or predictive connotation on the natural history of the disease or its responsiveness to therapy. In this chapter, we will discuss the significance of transcriptional signatures observed in pre-treatment biopsies as predictive of responsiveness to biological therapy. Moreover, we will discuss the transcriptional signatures observable during and after therapy documenting the switch from chronic to acute inflammation that leads to tumor rejection. We will further discuss how chemotherapy and viral oncolytic therapy, both believed to eliminate tumors exclusively through direct cytotoxicity may play an adjuvant role in stimulating this inflammatory switch. Finally, we will discuss how mechanisms leading to tumor rejection, largely overlap those associated with other aspects of immune-mediated tissue-specific destruction (TSD) such as allograft rejection, graft vs. host disease, acute clearance of pathogen and autoimmunity.
C1 [Wang, Ena; Marincola, Francesco M.] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
[Wang, Ena; Marincola, Francesco M.] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA.
RP Wang, E (reprint author), NIH, IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM ewang@mail.cc.nih.gov; FMarincola@mail.cc.nih.gov;
FMarincola@mail.cc.nih.gov; ewang@mail.cc.nih.gov
NR 138
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7218-7
PY 2011
BP 281
EP 304
DI 10.1007/978-1-4419-7219-4_18
D2 10.1007/978-1-4419-7219-4
PG 24
WC Oncology
SC Oncology
GA BSH95
UT WOS:000284503300018
ER
PT B
AU Bedognetti, D
AF Bedognetti, Davide
BE Marincola, FM
Wang, E
TI Signatures Associated with Acute Rejection: Allograft Rejection
SO IMMUNOLOGIC SIGNATURES OF REJECTION
LA English
DT Article; Book Chapter
ID NF-KAPPA-B; ACUTE CELLULAR REJECTION; CHEMOKINE RECEPTOR CXCR3; HUMAN
RENAL-ALLOGRAFTS; KIDNEY-TRANSPLANT REJECTION; TRANSCRIPTION FACTOR
IRF-1; ADAPTIVE IMMUNE-RESPONSES; GENE-EXPRESSION PROFILES; TOLL-LIKE
RECEPTORS; GROWTH-FACTOR-BETA
AB The physiopathology of immune-mediated tissue injury of acute allograft rejection is not completely understood. Although several mechanicistic experiments have been conducted in vitro and in animal models, only few hypotheses have been confirmed in humans and, paradoxically, findings in humans often lack mechanistic explanations. Before high throughput gene expression analysis advent (microarrays), the use of optic microscopy, immunohistochemistry and reverse transcriptase protein chain reaction (RT-PCR), allowed the "in situ" evaluation of only a few variables simultaneously. Conversely, the integration of the aforementioned methodologies with microarrays has cast new lights on unrecognized mechanisms that are now deemed as central for the development of the alloresponse. Pari passu with underlining the molecular heterogeneity between apparently similar lesions, this approach has also unveiled the activation of common mechanisms among clinically and histopathologically different lesions.
Universal standardization procedures were slowly and incompletely developed while microarray methodology was at its dawn and in continuing evolution. Moreover, the lack of uniformity among different investigating groups (in terms of sample collect ion, microarray platforms, genes coverage, bioinformatic analysis and study design) has probably been one of the reasons accounting for the relatively small overlap in the relevant genes detected by individual studies. Nevertheless, in spite of the aforementioned limitations, it is difficult to ignore the relevance of those gene/gene pathways consistently detected as simultaneously upregulated among independent studies even in the presence of such technical and analytic limitations.
The aim of this chapter is to shed some light on the physiopathology of allorejection, pointing at the activation of genes and molecular pathways thought to play a leading role in the development and/or maintenance of the tissue destructive process, which characterizes acute rejection.
Rather than trying to explain the cause of the activation of this acute response, we will try to depict a molecular fresco of the battlefield where tissue destruction is fought. To this purpose, we will focus on human microarray studies performed on tissue biopsies taken during episodes of acute allograft rejection, providing also a brief description of the results obtained with other approaches (RT-PCR or immunohistochemistry).
We will apply the knowledge derived from mechanicistic studies and from inductive and deductive reasoning to explain the possible roles and relations of the described pathways.
C1 [Bedognetti, Davide] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA.
[Bedognetti, Davide] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA.
[Bedognetti, Davide] Univ Genoa, Dept Oncol Biol & Genet, Genoa, Italy.
[Bedognetti, Davide] Univ Genoa, Dept Internal Med, I-16126 Genoa, Italy.
RP Bedognetti, D (reprint author), NIH, IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM davide.bedognetti@nih.gov
OI Bedognetti, Davide/0000-0002-5857-773X
NR 182
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7218-7
PY 2011
BP 305
EP 345
DI 10.1007/978-1-4419-7219-4_19
D2 10.1007/978-1-4419-7219-4
PG 41
WC Oncology
SC Oncology
GA BSH95
UT WOS:000284503300019
ER
PT B
AU Simonsen, L
Viboud, C
Taylor, RJ
Miller, MA
AF Simonsen, Lone
Viboud, Cecile
Taylor, Robert J.
Miller, Mark A.
BE Rappuoli, R
DelGiudice, G
TI The Epidemiology of Influenza and Its Control
SO INFLUENZA VACCINES FOR THE FUTURE, SECOND EDITION
SE Birkhauser Advances in Infectious Diseases
LA English
DT Article; Book Chapter
ID RESPIRATORY SYNCYTIAL VIRUS; PANDEMIC INFLUENZA; UNITED-STATES;
PUBLIC-HEALTH; HONG-KONG; VACCINATING SCHOOLCHILDREN; ELDERLY PERSONS;
CAUSE MORTALITY; A VIRUS; DEATHS
AB In this chapter we highlight how recent advances in influenza epidemiology can inform strategies for disease control Given the challenge of direct measurement, influenza epidemiology has benefited greatly from statistical inference from the analysts of large datasets regarding hospitalization, mortality, and outpatient visits associated with seasonal circulation of influenza viruses These data have allowed comparison of the impact of influenza in various climates and the evaluation of the direct and indirect benefits of vaccination, the latter through the vaccination of 'transmitter populations' such as school children, to achieve herd immunity Moreover, the resolution of influenza epidemiology has undergone a leap to the molecular level due to the integration of new antigenic and viral genomic data with classical epidemiological indicators Finally, the new data have led to an infusion of quantitative studies from the fields of evolutionary biology, population genetics and mathematics Molecular influenza epidemiology is providing deeper insight into temporal/spatial patterns of viruses, the important role of reassortment in generating genetic novelty and global diffusion of virus variants - including the role of the tropics as a source of new variants Higher resolution contemporary and historic epidemiological data provide a more detailed picture of the effect of age and other host characteristics on outcomes, as well as better estimates of the transmissibility of pandemic and seasonal influenza viruses New epidemiologic and virologic data from the current A/H1N1pdm 2009 pandemic improve our understanding of the emergence and establishment of new viral subtypes in human populations and their mortality and morbidity burden in the first years of circulation Re-examination of observational studies of vaccine effectiveness in seniors is leading to reconsideration of seasonal and pandemic vaccine priorities, while mathematical modelers have developed tools to explore optimal strategies for mitigating on-going and future pandemics The field of influenza epidemiology has rapidly progressed in the past decade and become truly multidisciplinary Progress could be sustained in the next decade by further interdisciplinary studies between virology, evolutionary biology, immunology, and clinical outcomes
C1 [Simonsen, Lone; Viboud, Cecile; Miller, Mark A.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
[Taylor, Robert J.] SAGE Analyt LLC, Bethesda, MD USA.
[Simonsen, Lone] George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
RP Miller, MA (reprint author), NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
OI Simonsen, Lone/0000-0003-1535-8526
NR 133
TC 6
Z9 7
U1 1
U2 7
PU BIRKHAUSER VERLAG AG
PI BASEL
PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND
BN 978-3-0346-0278-5
J9 BIRKHAUSER ADV INFEC
JI Birk. Adv. Infect. Dis.
PY 2011
BP 27
EP 54
DI 10.1007/978-3-0346-0279-2_2
D2 10.1007/978-3-0346-0279-2
PG 28
WC Infectious Diseases
SC Infectious Diseases
GA BSD79
UT WOS:000284236900002
ER
PT B
AU Luke, CJ
Subbarao, K
AF Luke, Catherine J.
Subbarao, Kanta
BE Rappuoli, R
DelGiudice, G
TI The Role of Animal Models In Influenza Vaccine Research
SO INFLUENZA VACCINES FOR THE FUTURE, SECOND EDITION
SE Birkhauser Advances in Infectious Diseases
LA English
DT Article; Book Chapter
ID LOWER RESPIRATORY-TRACT; A VIRUS-INFECTION; I RANDOMIZED-TRIAL; H5N1
VIRUSES; HONG-KONG; HETEROSUBTYPIC IMMUNITY; SOUTHERN CHINA; PROTECTIVE
IMMUNITY; HEALTHY-ADULTS; INACTIVATED INFLUENZA
AB A major challenge for research on influenza vaccines is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans Vaccines for seasonal influenza have been available for decades and there is a wealth of data available on the immune response to these vaccines in humans with well-established correlates of protection for inactivated influenza virus vaccines Many of the seminal studies on vaccines for epidemic influenza have been conducted in human subjects Studies in humans are performed less frequently now than they were in the past Therefore as the quest for improved influenza vaccines continues, it is important to consider the use of animal models for the evaluation of influenza vaccines, and a major challenge is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans
The emergence of highly pathogenic H5N1 avian influenza (AI) viruses and the threat of a pandemic caused by AI viruses of this or another subtype has resulted in a resurgence of interest in influenza vaccine research The development of vaccines for pandemic influenza presents a unique set of obstacles not the least of which is that the demonstration of efficacy in humans is not possible As the correlates of protection from pandemic influenza are not known, we rely on extrapolation of the lessons from seasonal influenza vaccines and on data from the evaluation of pandemic influenza vaccines in animal models to guide our decisions on vaccines for use in humans The features and contributions of commonly used animal models for influenza vaccine research are discussed The recent emergence of the pandemic 2009 H1N1 influenza virus underscores the unpredictable nature of influenza viruses and the importance of pandemic preparedness
C1 [Luke, Catherine J.; Subbarao, Kanta] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Luke, CJ (reprint author), NIAID, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
NR 184
TC 1
Z9 1
U1 2
U2 3
PU BIRKHAUSER VERLAG AG
PI BASEL
PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND
BN 978-3-0346-0278-5
J9 BIRKHAUSER ADV INFEC
JI Birk. Adv. Infect. Dis.
PY 2011
BP 223
EP 272
DI 10.1007/978-3-0346-0279-2_10
D2 10.1007/978-3-0346-0279-2
PG 50
WC Infectious Diseases
SC Infectious Diseases
GA BSD79
UT WOS:000284236900010
ER
PT B
AU Akagi, K
Yi, M
Roayaei, J
Stephens, RM
AF Akagi, Keiko
Yi, Ming
Roayaei, Jean
Stephens, Robert M.
BE Dupuy, AJ
Largaespada, DA
TI Bioinformatics of High-Throughput Insertional Mutagenesis
SO INSERTIONAL MUTAGENESIS STRATEGIES IN CANCER GENETICS
LA English
DT Article; Book Chapter
ID GENE SET ENRICHMENT; NEXT-GENERATION; SLEEPING-BEAUTY; SEQUENCE
DATABASE; IDENTIFIES GENES; MICROARRAY DATA; SITE SELECTION; ANALYSIS
TOOL; MOUSE GENOME; CANCER
AB Bioinformatics plays critical roles to handle large amount of sequence data from insertional mutagenesis. First, computational approaches are used to develop rapid sequence analysis pipelines and biological databases. Millions of reads from an insertion mutagenesis screening are mapped to genomic locations and be annotated to their target genes rapidly by pipeline, and such sequence-based data is stored and managed in database to share the information in the scientific community. Second, statistical techniques are used to distinguish true common insertion sites (loci that have been hit by insertions in multiple tumors: candidate loci for cancer genes) from background insertions in large-scale screenings. Finally, the advanced data mining techniques, pathway and network analysis, are used to give further biological meaning to insertion sites by identifying the interaction of genes in cancer. In this chapter, we discuss features of these three topics and address their future roles: (1) development of sequence analysis pipeline and database, (2) detection of common insertion sites, and (3) network and pathway analysis of insertion sites.
C1 [Akagi, Keiko] NCI, Mol Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA.
[Akagi, Keiko] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Yi, Ming; Stephens, Robert M.] NCI, Adv Technol Program, Adv Biomed Comp Ctr, SAIC Frederick Inc, Frederick, MD 21702 USA.
[Roayaei, Jean] SAIC Frederick, Stat Consulting Grp, Frederick, MD 21701 USA.
RP Akagi, K (reprint author), NCI, Mol Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA.
EM keiko.akagi@osumc.edu; yiming@mail.nih.gov; roayaei456@mail.nih.gov;
stephensr@mail.nih.gov
NR 82
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7655-0
PY 2011
BP 167
EP 188
DI 10.1007/978-1-4419-7656-7_7
D2 10.1007/978-1-4419-7656-7
PG 22
WC Oncology; Cell Biology; Genetics & Heredity
SC Oncology; Cell Biology; Genetics & Heredity
GA BSP87
UT WOS:000285329600007
ER
PT B
AU Sawitzke, JA
AF Sawitzke, James A.
BE Maloy, S
Hughes, KT
Casadesus, J
TI RECOMBINEERING: ADVANCED-ADVANCED BACTERIAL GENETICS
SO LURE OF BACTERIAL GENETICS: A TRIBUTE TO JOHN ROTH
LA English
DT Article; Book Chapter
ID ESCHERICHIA-COLI; HOMOLOGOUS RECOMBINATION; MISMATCH REPAIR; IN-VIVO;
MUTAGENESIS; EFFICIENT; REPLACEMENT; MUTATIONS; SYSTEM
C1 NCI, Mol Control & Genet Sect, Gene Regulat & Chromosome Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA.
RP Sawitzke, JA (reprint author), NCI, Mol Control & Genet Sect, Gene Regulat & Chromosome Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA.
NR 29
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-538-7
PY 2011
BP 333
EP 340
PG 8
WC Biochemistry & Molecular Biology; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA BSL44
UT WOS:000284857100032
ER
PT B
AU Singh, V
Amdekar, S
Yadav, H
Mishra, NN
Jain, S
AF Singh, Vinod
Amdekar, Sarika
Yadav, Hariom
Mishra, Nagendra Nath
Jain, Shailini
BE Ahmad, I
Ahmad, F
Pichtel, J
TI Future Application of Probiotics: A Boon from Dairy Biology
SO MICROBES AND MICROBIAL TECHNOLOGY: AGRICULTURAL AND ENVIRONMENTAL
APPLICATIONS
LA English
DT Article; Book Chapter
ID HUMAN GASTROINTESTINAL-TRACT; LIVE BACTERIAL VACCINES; IMMUNE-SYSTEM;
LACTOBACILLUS STRAINS; ROTAVIRUS INFECTION; INTESTINAL MUCUS; FERMENTED
MILK; RESPONSES; CELLS; IMMUNIZATION
AB Microbes have been used for millenia in food and alcoholic fermentations; in recent years, microbes have undergone scientific scrutiny of their ability for preventive and therapeutic effects in humans. This work has led to the establishment of a new term, "probiotics." Lactic acid bacteria (LAB) are normal microflora of the intestine of most animals. They play an important role in humans and other animals and act as an immunomodulator. LAB are helpful in disease treatment and prevention, as well as for improved digestion and absorption of nutrients. Probiotic microorganisms include LAB i.e., Lactobacillus acidophilus, L. bulgaricus, L. casei, L. plantarum, L. rhamnosus, etc. Use of these live bacteria to elicit an immune response or to carry a vaccine component is a new development in vaccine formulation. The advantages of live bacterial vaccines are their ability to mimic the natural infection, their intrinsic adjuvant properties, and that they can be administered orally. Components of pathogenic and nonpathogenic food-related microbes are currently being evaluated as candidates for oral vaccines.
C1 [Singh, Vinod; Amdekar, Sarika] Barkatullah Univ, Dept Microbiol, Bhopal 462026, India.
[Yadav, Hariom] NIDDK, Regenerat Biol Sect, Clin Res Ctr, NIH,Diabet Branch, Bethesda, MD 20892 USA.
[Mishra, Nagendra Nath] Univ Calif Los Angeles, Los Angeles Biomed Res Inst Harbor, Div Infect Dis, Med Ctr, Torrance, CA 90502 USA.
[Jain, Shailini] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA.
RP Singh, V (reprint author), Barkatullah Univ, Dept Microbiol, Bhopal 462026, India.
EM vinodsingh63@yahoo.co.in
NR 68
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7930-8
PY 2011
BP 87
EP 100
DI 10.1007/978-1-4419-7931-5_4
D2 10.1007/978-1-4419-7931-5
PG 14
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA BTP00
UT WOS:000287674400004
ER
PT B
AU Redon, CE
Dickey, JS
Nakamura, AJ
Martin, OA
Bonner, WM
AF Redon, Christophe E.
Dickey, Jennifer S.
Nakamura, Asako J.
Martin, Olga A.
Bonner, William M.
BE DeWeese, TL
Laiho, M
TI H2AX in DNA Damage Response
SO MOLECULAR DETERMINANTS OF RADIATION RESPONSE
SE Current Cancer Research
LA English
DT Article; Book Chapter
DE gamma-H2AX foci; Double-strand break repair; Ionizing radiation; Cancer;
Clinical applications; Environmental toxins
ID DOUBLE-STRAND BREAKS; PHOSPHORYLATED HISTONE H2AX; FIELD
GEL-ELECTROPHORESIS; PERIPHERAL-BLOOD LYMPHOCYTES; DOSE-RATE
IRRADIATION; GAMMA-H2AX FOCI; ATAXIA-TELANGIECTASIA; CELLULAR
SENESCENCE; GENOMIC INSTABILITY; IONIZING-RADIATION
AB Histone H2AX is a tumor suppressor, helping to preserve genome integrity. It does this by becoming massively and quickly phosphorylated at the sites of nascent DNA double-strand breaks (DSBs) in chromatin. In this chapter, we discuss the state of current knowledge concerning the various aspects of H2AX metabolism, including DSB formation, H2AX phosphorylation to form foci, foci size, and foci stoichiometry with DSBs. While H2AX is essential for efficient DSB repair, it is not essential for basic DSB repair. Mice lacking H2AX are viable under sterile conditions. However, H2AX plays an essential role in two processes necessary for long-term animal survival: immune system development and male fertility. We discuss the phosphorylation of H2AX during telomere dysfunction, interrupted replication/transcription, virus infection, and apoptosis. Phosphorylated H2AX foci serve as platforms for the recruitment of DNA repair and chromatin remodeling factors as well as factors involved in the cell-cycle checkpoint. Phosphorylated H2AX foci are also useful to detect DSBs related to cancer, senescence, and the radiation-induced bystander effect. We conclude by discussing clinical applications which are also coming to the forefront. These include applications in radiation biodosimetry, individual radiosensitivity, efficiency of chemotherapeutic agents to damage cancer and normal cells, and the evaluation of environmental toxins.
C1 [Redon, Christophe E.; Dickey, Jennifer S.; Nakamura, Asako J.; Martin, Olga A.; Bonner, William M.] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Bonner, WM (reprint author), NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bonnerw@mail.nih.gov
NR 180
TC 3
Z9 3
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-8043-4
J9 CURR CANCER RES
PY 2011
BP 3
EP 33
DI 10.1007/978-1-4419-8044-1_1
D2 10.1007/978-1-4419-8044-1
PG 31
WC Oncology
SC Oncology
GA BUG37
UT WOS:000289213000001
ER
PT B
AU Wang, XW
Grisham, JW
Thorgeirsson, SS
AF Wang, Xin Wei
Grisham, Joe W.
Thorgeirsson, Snorri S.
BE Wang, XW
Grisham, JW
Thorgeirsson, SS
TI Biology of Hepatocellular Carcinoma: Past, Present and Beyond
SO MOLECULAR GENETICS OF LIVER NEOPLASIA
SE Cancer Genetics-Series
LA English
DT Article; Book Chapter
DE Primary liver cancer; Hepatocellular carcinoma; Hepatitis B virus;
Hepatitis C virus; Aflatoxin; TP53 mutation; Chronic liver disease;
Cancer biomarker; Cancer screening; Therapy; Liver transplantation;
Alpha fetoprotein; AFP-L3; Tumor staging; Cirrhosis; HCC metastasis;
Genetic signature; cDNA microarray; transcriptomics;
Hepatocarcinogenesis; Tumor suppressor gene; Oncogene; microRNA;
Molecular; Personalized cancer care
ID HEPATITIS-B-VIRUS; ABERRANT DNA METHYLATION; GLOBAL CANCER STATISTICS;
PRIMARY LIVER-CANCER; MOLECULAR PATHOGENESIS; ALPHA-FETOPROTEIN;
TRANSGENIC MICE; ALLELIC LOSSES; UNITED-STATES; BREAST-CANCER
AB Primary liver cancer (PLC) is the third most deadly and fifth most common cancer in the world (Parkin et al. 1999), with an estimated 626,000 or 5.7% of new cancer cases and almost as many deaths in 2002 (Parkin et al. 2005). Liver cancer is an ancient disease and its description can be found in Huangdi Neijing, an ancient Chinese medical textbook also known as Yellow Emperor's Inner Canon dated back over 2000 years ago. However, the first mentioned PLC case could be dated as early as 1849 by Carl Rokitansky and the definition of PLC, as referenced to metastatic liver cancer, was only formally established in 1888 by Victor Hanot and Augustin Gilbert, and in 1889 independently by Moriharu Miura (Hanot and Gilbert 1888; Rokitansky 1849; Yamagiwa 1911). Traditionally, PLC was considered as an incurable disease clue to an extremely poor outcome. Patients with PLC have been an underserved population since the. beginning of its discovery and the disease is becoming a major health burden worldwide. Clearly, there is a strong need in expanding basic and translational research on PLC with an ultimate goal to reduce its severity. Recent studies on HCC genetic and genomic analyses feature important advances in the understanding of the complex biological processes underlying tumorigenesis and metastasis of PLC, and demonstrate how these insights might translate into clinical applications. As we approach a golden era in PLC research, we anticipate a significant advance in our understanding of this disease in near future, We are confident that the knowledge gain from continuing research efforts on PLC undoubtedly facilitates the understanding of molecular mechanism and tumor biology to provide the best therapy for each cancer patient and to improve patient management.
C1 [Wang, Xin Wei] NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA.
[Grisham, Joe W.] Univ N Carolina, Chapel Hill, NC 27599 USA.
[Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
RP Wang, XW (reprint author), NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, 37 Convent Dr,MSC 4258,Bldg 37,Room 3044A, Bethesda, MD 20892 USA.
EM xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov;
xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov
NR 95
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6081-8
J9 CANCER GENET-SER
JI Cancer Genetics
PY 2011
BP 3
EP 17
DI 10.1007/978-1-4419-6082-5_1
D2 10.1007/978-1-4419-6082-5
PG 15
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA BSJ63
UT WOS:000284723700001
ER
PT B
AU Grisham, JW
Wang, XW
Thorgeirsson, SS
AF Grisham, Joe W.
Wang, Xin Wei
Thorgeirsson, Snorri S.
BE Wang, XW
Grisham, JW
Thorgeirsson, SS
TI Overview of Cholangiocarcinoma and Evidence for a Primary Liver
Carcinoma Spectrum
SO MOLECULAR GENETICS OF LIVER NEOPLASIA
SE Cancer Genetics-Series
LA English
DT Article; Book Chapter
DE Primary liver cancer; Hepatocellular carcinoma; Intrahepatic
cholangiocarcinoma; Overlap of primary liver cancers
ID COMBINED HEPATOCELLULAR-CHOLANGIOCARCINOMA; HUMAN INTRAHEPATIC
CHOLANGIOCARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; PROGENITOR-CELL
ORIGIN; BILIARY-TRACT CANCERS; ALBUMIN MESSENGER-RNA; IN-SITU
HYBRIDIZATION; WB-F344 RAT-LIVER; HEPATITIS-C; CHOLANGIOCELLULAR
CARCINOMA
AB Intrahepatic cholangiocarcinoma, second in incidence to hepatocellular carcinoma among the primary liver carcinomas, has an even more dismal prognosis. Intrahepatic cholangiocarcinoma is difficult to diagnose at an early stage of development and advances aggressively, with widespread metastases. Molecular genetic features of intrahepatic cholangiocarcinoma have been partially elucidated, although the specific genetic lesions and molecular processes that drive its development, progression, and metastasis are still obscure. Evidence has accumulated from many sources suggesting that cholangiocarcinoma and hepatocellular carcinoma are components of a spectrum of primary liver carcinomas, including poorly and aberrantly differentiated varieties. Primary liver carcinomas arise from cells in different stages of development that encompass the entire lineage of liver epithelial cells generated from hepatoblasts and/or adult liver stern cells, and share critical genomic aberrations and phenotypes with these progenitor cells.
C1 [Grisham, Joe W.] Univ N Carolina, Chapel Hill, NC 27599 USA.
[Wang, Xin Wei] NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA.
[Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
RP Grisham, JW (reprint author), Univ N Carolina, Chapel Hill, NC 27599 USA.
EM joe_grisham@med.unc.edu; xw3u@nih.gov; snorri_thorgeirsson@nih.gov;
xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov
NR 95
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6081-8
J9 CANCER GENET-SER
JI Cancer Genetics
PY 2011
BP 19
EP 33
DI 10.1007/978-1-4419-6082-5_2
D2 10.1007/978-1-4419-6082-5
PG 15
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA BSJ63
UT WOS:000284723700002
ER
PT B
AU Coulouarn, C
Thorgeirsson, SS
AF Coulouarn, Cedric
Thorgeirsson, Snorri S.
BE Wang, XW
Grisham, JW
Thorgeirsson, SS
TI Integrative and Functional Genomics of HCC
SO MOLECULAR GENETICS OF LIVER NEOPLASIA
SE Cancer Genetics-Series
LA English
DT Article; Book Chapter
DE Hepatocellular carcinoma; Gene expression profiling;
Comparative-integrative functional genomics; System biology
ID HUMAN HEPATOCELLULAR-CARCINOMA; DIFFERENTIAL GENE-EXPRESSION; CDNA
MICROARRAY ANALYSIS; HUMAN CANCER; MOUSE MODELS; LIVER-CANCER;
HEPATITIS-B; NONALCOHOLIC STEATOHEPATITIS; OLIGONUCLEOTIDE MICROARRAY;
THERAPEUTIC TARGETS
AB In this chapter, we review the impact of functional and integrative genomics on hepatocellular carcinoma (HCC) research over the last decade. We focus on how genome-wide and high-throughput technologies have been used successfully to classify HCC at a molecular level and became important tools to refine the diagnosis and prognosis predictions of HCC. We also describe how cross-species comparative oncogenomic emerged as a powerful strategy to improve HCC prognostication, as well as to highlight evolutionally conserved regulatory modules or pathways that may be critical in hepatocarcinogenesis. In order to achieve a complete understanding of the molecular mechanisms involved in the disease, the field is now shifting toward integrative genomics, which now combines multi-parametric data reflecting alterations at genomic, genetic and epigenetic levels. Undoubtedly, functional and integrative genomics promise to yield unprecedented biological insights into the pathogenesis of HCC and will ultimately converge toward a personalized medicine that will improve diagnosis, treatment and prevention of liver cancer.
C1 [Coulouarn, Cedric] Univ Rennes 1, INSERM, UMR 991, Hop Pontchaillou, F-35033 Rennes, France.
[Coulouarn, Cedric] Univ Rennes 1, INSERN, UMR 991, Hop Pontchaillou, F-35033 Rennes, France.
[Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
RP Coulouarn, C (reprint author), Univ Rennes 1, INSERM, UMR 991, Hop Pontchaillou, F-35033 Rennes, France.
EM cedric.coulouarn@univ-rennes1.fr; snorri_thorgeirsson@nih.gov
RI Coulouarn, Cedric/E-5472-2011
NR 68
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6081-8
J9 CANCER GENET-SER
JI Cancer Genetics
PY 2011
BP 221
EP 240
DI 10.1007/978-1-4419-6082-5_12
D2 10.1007/978-1-4419-6082-5
PG 20
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA BSJ63
UT WOS:000284723700012
ER
PT S
AU Newbold, RR
AF Newbold, Retha R.
BE Lustig, RH
TI Perinatal Exposure to Endocrine Disrupting Chemicals with Estrogenic
Activity and the Development of Obesity
SO OBESITY BEFORE BIRTH: MATERNAL AND PRENATAL INFLUENCES ON THE OFFSPRING
SE Endocrine Updates
LA English
DT Article; Book Chapter
ID EPIGENETIC TRANSGENERATIONAL ACTIONS; IN-UTERO EXPOSURE; BISPHENOL-A;
ENVIRONMENTAL ESTROGENS; METABOLIC SYNDROME; ADULT DISEASE; FETAL
ORIGINS; CD-1 MICE; DIETHYLSTILBESTROL; EPIDEMIC
C1 [Newbold, Retha R.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
EM newbold1@niehs.nih.gov
NR 83
TC 2
Z9 2
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 1566-0729
BN 978-1-4419-7033-6
J9 ENDOCR UPDAT
PY 2011
BP 367
EP 382
DI 10.1007/978-1-4419-7034-3_18
D2 10.1007/978-1-4419-7034-3
PG 16
WC Endocrinology & Metabolism; Obstetrics & Gynecology
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA BRK21
UT WOS:000282900300018
ER
PT B
AU McTiernan, A
Nebeling, L
Ballard-Barbash, R
AF McTiernan, Anne
Nebeling, Linda
Ballard-Barbash, Rachel
BE McTiernan, A
TI Physical Activity, Dietary Calorie Restriction, and Cancer Introduction
SO PHYSICAL ACTIVITY, DIETARY CALORIE RESTRICTION, AND CANCER
SE Energy Balance and Cancer
LA English
DT Editorial Material; Book Chapter
AB An increasing body of literature has linked overweight, obesity, and a sedentary lifestyle to increased risk for several types of cancers These lifestyle factors have also been associated with prognosis of several types of cancers This volume provides a review of the state of the science on the role of energy balance, physical activity, and cancer incidence and prognosis, as well as mechanisms that may underlie associations of energy balance with cancer risk and prognosis The epidemic of overweight and obesity and the increasing sedentary lifestyles will impact the magnitude and quality of the cancer problem globally Increasing the knowledge of scientists, clinicians, and policy experts will aid in defining new prevention and treatment methods, to reduce the impact of energy balance on cancer, with the goal to eventually reduce the burden of cancer
C1 [McTiernan, Anne] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
[Nebeling, Linda] NCI, Div Canc Control & Populat Sci, Behav Res Program, Bethesda, MD USA.
[Ballard-Barbash, Rachel] NCI, Div Canc Control & Populat Sci, Appl Res Program, Bethesda, MD USA.
RP McTiernan, A (reprint author), Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
NR 7
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7550-8
J9 ENERG BALANCE CANCER
JI Energy Balance Canc.
PY 2011
VL 3
BP 1
EP 3
DI 10.1007/978-1-4419-7551-5_1
D2 10.1007/978-1-4419-7551-5
PG 3
WC Oncology; Nutrition & Dietetics
SC Oncology; Nutrition & Dietetics
GA BSP28
UT WOS:000285267100001
ER
PT B
AU Maley, CC
Szabo, E
Reid, BJ
AF Maley, Carlo C.
Szabo, Eva
Reid, Brian J.
BE Fitzgerald, RC
TI Somatic Evolution in Neoplastic Progression and Cancer Prevention
SO PRE-INVASIVE DISEASE: PATHOGENESIS AND CLINICAL MANAGEMENT
LA English
DT Article; Book Chapter
ID ACUTE MYELOID-LEUKEMIA; TRANS-RETINOIC ACID; CELL LUNG-CANCER; 2ND
PRIMARY TUMORS; GENE AMPLIFICATION; BETA-CAROTENE; INTRAEPITHELIAL
NEOPLASIA; COLORECTAL ADENOMA; MULTISTAGE CARCINOGENESIS; ESOPHAGEAL
ADENOCARCINOMA
AB Cancers develop through a process of somatic evolution Thus, cancer prevention can be viewed as an attempt to change the selective pressures on tissues to either prevent or delay cancer onset. However, chemoprevention efforts have met with mixed success to date. Most of the cancer prevention trials that have failed have been in high risk patients that are either late in progression or have had chronic mutagenic exposures like cigarette smoke We hypothesize that some of these trials fail because they select for clones that are resistant to the intervention and actually benefit those clones by suppressing their competitors. The evolutionary understanding of neoplastic progression leads to a variety of predictions and prescriptions for cancer prevention: We should be measuring the selective impact of our interventions in order to discover and manage the evolution of. resistance Pre-clinical models with extensive intratumor genetic heterogeneity should be developed to better predict clinical outcomes. Resistance is less likely to develop prior to the evolution of genetic and epigenetic instability. We should develop measures of the dynamics of somatic evolution so that we can develop interventions to slow the process of neoplastic progression Multidrug cancer prevention cocktails should be developed that require multiple alterations in order for cells to become resistant to the cocktail. Finally, we should develop cancer prevention interventions with the goal of preventing, channeling of managing somatic evolution. Because somatic evolution is at the heart of neoplastic progression, it must be at the heart of how we manage the disease
C1 [Maley, Carlo C.] Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, Philadelphia, PA 19104 USA.
[Szabo, Eva] NCI, Lung & Upper Aerodigest Canc Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA.
[Reid, Brian J.] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA.
[Reid, Brian J.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
[Reid, Brian J.] Univ Washington, Dept Med, Seattle, WA 98195 USA.
[Reid, Brian J.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
RP Maley, CC (reprint author), Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, 3600 Spruce St, Philadelphia, PA 19104 USA.
NR 88
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6693-3
PY 2011
BP 111
EP 127
DI 10.1007/978-1-4419-6694-0_7
D2 10.1007/978-1-4419-6694-0
PG 17
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA BRT38
UT WOS:000283620600007
ER
PT B
AU Ivy, SP
Egorin, MJ
Takimoto, CH
Wick, JY
AF Ivy, S. Percy
Egorin, Merrill J.
Takimoto, Chris H.
Wick, Jeannette Y.
BE Hidalgo, M
Eckhardt, SG
GarrettMayer, E
Clendeninn, NJ
TI Clinical Trials in Special Populations
SO PRINCIPLES OF ANTICANCER DRUG DEVELOPMENT
SE Cancer Drug Discovery and Development
LA English
DT Article; Book Chapter
ID GLOMERULAR-FILTRATION-RATE; NATIONAL-CANCER-INSTITUTE;
DYSFUNCTION-WORKING-GROUP; IMPAIRED RENAL-FUNCTION; MULTIPLE-MYELOMA
PATIENTS; SERUM CYSTATIN-C; CELL LUNG-CANCER; PHASE-I TRIALS; CREATININE
CLEARANCE; ELDERLY-PATIENTS
C1 [Ivy, S. Percy] NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Invest Drug Branch, Rockville, MD 20852 USA.
[Egorin, Merrill J.] Univ Pittsburgh, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA.
[Takimoto, Chris H.] Ortho Biotech Oncol R&D, Radnork, PA 19087 USA.
[Wick, Jeannette Y.] NCI, Canc Therapy Evaluat Program, Pharmaceut Management Branch, Rockville, MD USA.
RP Ivy, SP (reprint author), NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Invest Drug Branch, 6130 Execut Blvd,Suite 7131, Rockville, MD 20852 USA.
EM ivyp@ctep.nci.nih.gov; egorinmj@upmc.edu; CTakimot@its.jnj.com;
wickj@ctep.nci.nih.gov
NR 92
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-4419-7357-3
J9 CANCER DRUG DISCOV D
JI Canc. Drug. Disc. Dev.
PY 2011
BP 603
EP 628
DI 10.1007/978-1-4419-7358-0_22
PG 26
WC Oncology; Pharmacology & Pharmacy
SC Oncology; Pharmacology & Pharmacy
GA BTC93
UT WOS:000286531700022
ER
PT B
AU Dudley, JP
Mertz, JA
Bhadra, S
Palmarini, M
Kozak, CA
AF Dudley, Jaquelin P.
Mertz, Jennifer A.
Bhadra, Sanchita
Palmarini, Massimo
Kozak, Christine A.
BE Dudley, J
TI Endogenous Retroviruses and Cancer
SO RETROVIRUSES AND INSIGHTS INTO CANCER
LA English
DT Article; Book Chapter
DE Endogenous provirus; Recombination; Host immunity; Pathogenesis; ERVs
ID MAMMARY-TUMOR VIRUS; MURINE LEUKEMIA-VIRUS; JAAGSIEKTE SHEEP RETROVIRUS;
LONG TERMINAL REPEAT; T-CELL LYMPHOMAS; B LEUKEMOGENIC VIRUS; AVIAN
HEMANGIOMA RETROVIRUS; FOCUS-FORMING VIRUSES; ENZOOTIC NASAL TUMOR;
HUMAN BREAST-CANCER
AB Endogenous retroviruses (ERVs) abound in avian and mammalian genomes, including humans, as a result of germline infections by exogenous retroviruses. Most ERVs are defective for production of infectious virus. The defectiveness of ERVs is generally inversely correlated with the length of their residence in the host germline. These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. Ancient ERVs likely have neutral or beneficial roles for the hosts that carry them. However, multiple examples show that additional pathogenic retroviruses will continue to emerge using ERVs as a source of genetic diversity.
C1 [Dudley, Jaquelin P.; Mertz, Jennifer A.; Bhadra, Sanchita] Univ Texas Austin, Sect Mol Genet & Microbiol, Austin, TX 78712 USA.
[Dudley, Jaquelin P.; Mertz, Jennifer A.; Bhadra, Sanchita] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA.
[Dudley, Jaquelin P.] Univ Texas Austin, Inst Cell & Mol Biol, Austin, TX 78712 USA.
[Palmarini, Massimo] Univ Glasgow, MRC Univ Glasgow, Inst Infect Immun & Inflammat, Ctr Virus Res,Coll Med Vet & Life Sci, Glasgow G61 1QH, Lanark, Scotland.
[Kozak, Christine A.] NIAID, Mol Microbiol Lab, Viral Biol Sect, NIH, Bethesda, MD 20892 USA.
RP Dudley, JP (reprint author), Univ Texas Austin, Sect Mol Genet & Microbiol, 1 Univ Stn,A5000, Austin, TX 78712 USA.
EM jdudley@uts.cc.utexas.edu; mertzja@gmail.com; sanchitabhadra@yahoo.com;
m.palmarini@vet.gla.ac.uk; ckozak@niaid.nih.gov
NR 277
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-0-387-09580-6
PY 2011
BP 119
EP 162
DI 10.1007/978-0-387-09581-3_5
D2 10.1007/978-0-387-09581-3
PG 44
WC Oncology; Virology
SC Oncology; Virology
GA BSA42
UT WOS:000284029800005
ER
PT B
AU Ryall, JG
Lynch, GS
AF Ryall, James G.
Lynch, Gordon S.
BE Lynch, GS
TI Role of beta-Adrenergic Signalling in Skeletal Muscle Wasting:
Implications for Sarcopenia
SO SARCOPENIA-AGE-RELATED MUSCLE WASTING AND WEAKNESS: MECHANISMS AND
TREATMENTS
LA English
DT Article; Book Chapter
DE beta-adrenoceptor agonist; beta-adrenergic signalling; cardiac muscle;
fibre type; G-protein couple receptor; heart; muscle hypertrophy; muscle
wasting; skeletal muscle
ID PROTEIN-COUPLED RECEPTORS; FOXO TRANSCRIPTION FACTORS; HETEROTRIMERIC
G-PROTEINS; GAMMA-SUBUNITS; MESSENGER-RNA; FIBER-TYPE; OLD RATS;
MUSCULAR-DYSTROPHY; HEART-FAILURE; KINASE-B
AB While the importance of beta-adrenergic signalling in the heart has been well documented for more than half a century and continues to receive significant attention, it is only more recently that we have begun to understand the importance of this signalling pathway in skeletal muscle. There is considerable evidence regarding the stimulation of the beta-adrenergic system with beta-adrenoceptor agonists (beta-agonists) in animals and humans. Although traditionally used for the treatment of bronchospasm, it became apparent that some beta-agonists, such as clenbuterol, had the ability to increase skeletal muscle mass and decrease body fat (Ricks et al. 1984; Beerman et al. 1987). These so-called "repartitioning effects" proved desirable for those working in the livestock industry trying to improve feed efficiency and meat quality (Sillence 2004). Not surprisingly, beta(2)-agonists were soon being used by those engaged in competitive bodybuilding and by other athletes, especially those engaged in strength- and power-related sports (Lynch 2002; Lynch and Ryall 2008).
As a consequence of their muscle anabolic actions, the effects of beta-agonist administration on skeletal muscle have been examined in a number of animal models (and in humans) with the hope of discovering therapeutic applications, particularly for muscle wasting conditions including sarcopenia (age-related muscle wasting and associated weakness), cancer cachexia, sepsis, and other forms of metabolic stress, denervation, disuse, inactivity, unloading or microgravity, burns, HIV-acquired immunodeficiency syndrome (AIDS), chronic kidney or heart failure, chronic obstructive pulmonary disease, muscular dystrophies, and other neuromuscular disorders. For many of these conditions, the anabolic properties of beta-agonists have the potential to attenuate (or potentially reverse) the muscle wasting, muscle fibre atrophy, and associated muscle weakness. beta-agonists also have clinical significance for enhancing muscle repair and restoring muscle function after injury or following reconstructive surgery.
In addition to having anabolic effects on skeletal muscle, beta-agonists have also been associated with some undesirable side effects, including increased heart rate (tachycardia) and muscle tremor, which have so far limited their therapeutic potential. In this chapter we describe the physiological significance of beta-adrenergic signalling in skeletal muscle and discuss the therapeutic potential of beta-adrenergic stimulation for age-related muscle wasting and weakness. We describe the effects of current beta-agonists on skeletal muscle and identify novel research strategies to minimize the unwanted side-effects associated with systemic beta-adrenergic stimulation.
C1 [Lynch, Gordon S.] Univ Melbourne, Dept Physiol, Basic & Clin Myol Lab, Melbourne, Vic 3010, Australia.
[Ryall, James G.] Natl Inst Arthrit Musculoskeletal & Skin Dis, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD USA.
RP Lynch, GS (reprint author), Univ Melbourne, Dept Physiol, Basic & Clin Myol Lab, Melbourne, Vic 3010, Australia.
EM ryallj@mail.nih.gov; gsl@unimelb.edu.au
RI Lynch, Gordon/G-9553-2015
OI Lynch, Gordon/0000-0001-9220-9810
NR 142
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-90-481-9712-5
PY 2011
BP 449
EP 471
DI 10.1007/978-90-481-9713-2_19
D2 10.1007/978-90-481-9713-2
PG 23
WC Geriatrics & Gerontology; Sport Sciences
SC Geriatrics & Gerontology; Sport Sciences
GA BSR26
UT WOS:000285535100019
ER
PT S
AU Steven, AC
Cardone, G
Butan, C
Winkler, DC
Heymann, JB
AF Steven, Alasdair C.
Cardone, Giovanni
Butan, Carmen
Winkler, Dennis C.
Heymann, J. Bernard
BE AgbandjeMckenna, M
McKenna, R
TI Three-dimensional Structures of Pleiomorphic Viruses from Cryo-Electron
Tomography
SO STRUCTURAL VIROLOGY
SE RSC Biomolecular Sciences
LA English
DT Article; Book Chapter
ID HERPES-SIMPLEX-VIRUS; RECEPTOR-MEMBRANE COMPLEX; TO-NOISE RATIO;
ELECTRON TOMOGRAPHY; INFLUENZA-VIRUS; RESOLUTION CRITERION;
CRYSTAL-STRUCTURE; HIV-1 VIRIONS; TILT SERIES; CA PROTEIN
C1 [Steven, Alasdair C.; Cardone, Giovanni; Butan, Carmen; Winkler, Dennis C.; Heymann, J. Bernard] NIAMSD, Struct Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Steven, AC (reprint author), NIAMSD, Struct Biol Lab, NIH, Bethesda, MD 20892 USA.
NR 76
TC 3
Z9 3
U1 0
U2 1
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND
SN 1757-7152
BN 978-0-85404-171-8
J9 RSC BIOMOL SCI
JI RSC Biomol. Sci.
PY 2011
IS 21
BP 62
EP 80
PG 19
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BSV57
UT WOS:000285938100004
ER
PT S
AU Chen, K
Tjandra, N
AF Chen, Kang
Tjandra, Nico
BE AgbandjeMckenna, M
McKenna, R
TI Solution NMR Spectroscopy in Characterizing Structure, Dynamics and
Intermolecular Interactions of Retroviral Structural Proteins
SO STRUCTURAL VIROLOGY
SE RSC Biomolecular Sciences
LA English
DT Article; Book Chapter
ID HUMAN-IMMUNODEFICIENCY-VIRUS; NUCLEAR-MAGNETIC-RESONANCE;
MULTIDIMENSIONAL HETERONUCLEAR NMR; HIV-1 NUCLEOCAPSID PROTEIN; HUMAN
CYCLOPHILIN-A; CAPSID PROTEIN; DIPOLAR COUPLINGS; BIOLOGICAL
MACROMOLECULES; MATRIX PROTEIN; BIOMOLECULAR NMR
C1 [Chen, Kang; Tjandra, Nico] NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA.
RP Chen, K (reprint author), NHLBI, Lab Mol Biophys, NIH, Bldg 10, Bethesda, MD 20892 USA.
NR 68
TC 0
Z9 0
U1 0
U2 1
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND
SN 1757-7152
BN 978-0-85404-171-8
J9 RSC BIOMOL SCI
JI RSC Biomol. Sci.
PY 2011
IS 21
BP 135
EP 159
PG 25
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BSV57
UT WOS:000285938100008
ER
PT S
AU Schowalter, RM
Smith, EC
Dutch, RE
AF Schowalter, Rachel M.
Smith, Everett C.
Dutch, Rebecca Ellis
BE AgbandjeMckenna, M
McKenna, R
TI Attachment and Entry: Viral Cell Fusion
SO STRUCTURAL VIROLOGY
SE RSC Biomolecular Sciences
LA English
DT Article; Book Chapter
ID SEMLIKI-FOREST-VIRUS; VESICULAR STOMATITIS-VIRUS; RESPIRATORY SYNCYTIAL
VIRUS; BORNE ENCEPHALITIS-VIRUS; METAPNEUMOVIRUS-F-PROTEIN;
MEMBRANE-FUSION; LOW-PH; ENVELOPE GLYCOPROTEIN; PARAMYXOVIRUS FUSION;
EBOLA-VIRUS
C1 [Schowalter, Rachel M.] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Smith, Everett C.; Dutch, Rebecca Ellis] Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA.
RP Schowalter, RM (reprint author), NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 92
TC 2
Z9 2
U1 0
U2 1
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND
SN 1757-7152
BN 978-0-85404-171-8
J9 RSC BIOMOL SCI
JI RSC Biomol. Sci.
PY 2011
IS 21
BP 243
EP 260
PG 18
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BSV57
UT WOS:000285938100013
ER
PT B
AU Parchment, RE
AF Parchment, Ralph E.
BE Teicher, BA
TI Bone Marrow as a Critical Normal Tissue that Limits Drug Dose/Exposure
in Preclinical Models and the Clinic
SO TUMOR MODELS IN CANCER RESEARCH, SECOND EDITION
SE Cancer Drug Discovery and Development
LA English
DT Article; Book Chapter
DE Bone marrow; Hematopoiesis; Progenitor; Stem cell; Hematotoxicology;
Neutropenia; Myelosuppression; Dose limiting toxicity; Adverse drug
effect; Therapeutic index; Maximum tolerated dose; Prediction models;
CFU GM; Engraftment
ID HEMATOPOIETIC PROGENITOR CELLS; COLONY-FORMING CELLS; UMBILICAL-CORD
BLOOD; SCID IL2R-GAMMA(NULL) MICE; SOLID TUMOR XENOGRAFTS; VIVO
CULTURE-SYSTEM; CFU-GM ASSAY; IN-VIVO; PRECURSOR CELLS; STEM-CELLS
AB Mouse models of cancer have played an important role in the discovery and development of cytotoxic and targeted anticancer agents Initially discovery models used transplantable syngeneic tumors that were treated with doses maximally tolerated by the normal tissues of the mouse Thus experimental compounds were selected for development based on their selectivity for murine malignant tissue over murine normal tissue and the discovery method assumed that a murine therapeutic Index closely approximates a human therapeutic index for most compounds When mouse modeling migrated to the use of xenografted human malignancies in order that drug efficacy assessment would be more relevant for clinical disease there was not a corresponding transition to human normal tissue to determine the maximum tolerated dose (MTD) to use in treating the mouse Consequently drug discovery in these models has been based on selectivity for human malignant tissue over murine normal tissue This xeno therapeutic index has an unknown relationship either to a mouse or human therapeutic index these latter ones being determined by efficacy against cancer at the maximum dose tolerated by normal tissues from the same species of origin as the cancer The biological process of producing new blood cells is termed hematopoiesis and this process is a frequent target of toxicity of anticancer drugs including toxicity that limits dose Two recently established methods in experimental hematology and hematotoxicology are useful for deter mining the MTD of human hematopoiesis in the mouse The methods are suitable for implementation in the drug discovery setting and therefore could be used to discover new anticancer compounds that exhibit selectivity for malignant human tissue over normal human hematopoiesis in mouse models This chapter provides background information on hematopoiesis explains why it frequently limits the dose of anticancer drugs describes the two methods and then proposes ways in which the methods might contribute to mouse modeling of cancer therapy to improve predictive accuracy for clinical outcome
C1 NCI, Lab Human Toxicol & Pharmacol, SA1C Frederick Inc, Frederick, MD 21702 USA.
RP Parchment, RE (reprint author), NCI, Lab Human Toxicol & Pharmacol, SA1C Frederick Inc, Frederick, MD 21702 USA.
NR 99
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
BN 978-1-60761-967-3
J9 CANCER DRUG DISCOV D
JI Canc. Drug. Disc. Dev.
PY 2011
BP 521
EP 552
DI 10.1007/978-1-60761-968-0_21
D2 10.1007/978-1-60761-968-0
PG 32
WC Oncology; Pharmacology & Pharmacy
SC Oncology; Pharmacology & Pharmacy
GA BSV70
UT WOS:000285939500021
ER
PT S
AU Kim, YS
Pobezinskaya, Y
Choksi, S
Morgan, M
Li, T
Liu, CY
Liu, ZG
AF Kim, You-Sun
Pobezinskaya, Yelena
Choksi, Swati
Morgan, Michael
Li, Tao
Liu, Chengyu
Liu, Zhenggang
BE Wallach, D
Kovalenko, A
Feldman, M
TI THE FUNCTION OF TRADD IN SIGNALING THROUGH TUMOR NECROSIS FACTOR
RECEPTOR 1 AND TRIF-DEPENDENT TOLL-LIKE RECEPTORS
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Kim, You-Sun; Pobezinskaya, Yelena; Choksi, Swati; Morgan, Michael; Li, Tao; Liu, Zhenggang] NCI, Cell & Canc Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Liu, Chengyu] NHLBI, Transgen Core Facil, NIH, Bethesda, MD 20892 USA.
[Kim, You-Sun] Ajou Univ, Sch Med, Inst Med Sci, Suwon 443421, South Korea.
NR 0
TC 0
Z9 0
U1 6
U2 7
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 675
EP 675
PG 1
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300113
ER
PT S
AU Siegel, RM
Song, YJ
Fuss, I
Davidson, T
Shevach, E
Wang, E
Meylan, F
AF Siegel, Richard M.
Song, Yun-Jeong
Fuss, Ivan
Davidson, Todd
Shevach, Ethan
Wang, Eddie
Meylan, Francoise
BE Wallach, D
Kovalenko, A
Feldman, M
TI TL1A-DR3 INTERACTIONS IN T-CELL MEDIATED AUTOIMMUNITY
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Siegel, Richard M.; Song, Yun-Jeong; Meylan, Francoise] NIAMS, Immunoregulat Grp, Autoimmun Branch, Bethesda, MD 20892 USA.
[Fuss, Ivan] NIAID, Mucosal Immunol Sect, LICID, Bethesda, MD 20892 USA.
[Davidson, Todd; Shevach, Ethan] NIAID, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA.
[Wang, Eddie] Cardiff Univ, Cardiff, S Glam, Wales.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 683
EP 684
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300122
ER
PT S
AU Griessl, S
Chen, X
Oppenheim, JJ
Mannel, DN
AF Griessl, S.
Chen, X.
Oppenheim, J. J.
Maennel, D. N.
BE Wallach, D
Kovalenko, A
Feldman, M
TI THE DUAL ROLE OF TNF ON T CELL ACTIVATION
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 Univ Regensburg, Inst Immunol, D-8400 Regensburg, Germany.
NCI Frederick, Immunoregulat Lab, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 692
EP 693
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300133
ER
PT S
AU Yin, Q
Lin, SC
Lamothe, B
Lu, M
Lo, YC
Hura, G
Zheng, LX
Rich, RL
Campos, AD
Myszka, DG
Lenardo, MJ
Darnay, BG
Wu, H
AF Yin, Qian
Lin, Su-Chang
Lamothe, Betty
Lu, Miao
Lo, Yu-Chih
Hura, Gregory
Zheng, Lixin
Rich, Rebecca L.
Campos, Alejandro D.
Myszka, David G.
Lenardo, Michael J.
Darnay, Bryant G.
Wu, Hao
BE Wallach, D
Kovalenko, A
Feldman, M
TI CRYSTAL STRUCTURE OF TRAF6 REVEALS SPECIFICITY AND MECHANISM OF
TRAF6-MEDIATED UBIQUITINATION
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Yin, Qian; Lin, Su-Chang; Lo, Yu-Chih; Wu, Hao] Cornell Univ, Weill Med Coll, New York, NY 10021 USA.
[Yin, Qian; Wu, Hao] Tri Inst Training Program Chem Biol, New York, NY 10021 USA.
[Lamothe, Betty; Campos, Alejandro D.; Darnay, Bryant G.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.
[Lu, Miao; Hura, Gregory] Univ Calif Berkeley, Lawrence Berkeley Lab, Adv Light Source, Berkeley, CA 94720 USA.
[Zheng, Lixin; Lenardo, Michael J.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
[Rich, Rebecca L.; Myszka, David G.] Univ Utah, Sch Med, Ctr Biomol Interact Anal, Salt Lake City, UT 84132 USA.
EM haowu@med.cornell.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 699
EP 700
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300142
ER
PT S
AU Cleland, S
Nikolov, NP
Shimizu, M
Bailey, D
Aoki, J
Strom, T
Schwartzberg, PL
Candotti, F
Siegel, RM
AF Cleland, Sophia
Nikolov, Nikolay P.
Shimizu, Masaki
Bailey, Daniel
Aoki, Joseph
Strom, Ted
Schwartzberg, Pamela L.
Candotti, Fabio
Siegel, Richard M.
BE Wallach, D
Kovalenko, A
Feldman, M
TI FAS LIGAND SECRETION AND SELF-TOLERANCE IS REGULATED BY THE
WISKOTT-ALDRICH SYNDROME PROTEIN
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Nikolov, Nikolay P.] NIAMS, Off Clin Director, NIH, Bethesda, MD USA.
[Shimizu, Masaki; Candotti, Fabio] NHGRI, Disorders Immun Sect, GMBB, NIH, Bethesda, MD 20892 USA.
[Aoki, Joseph; Schwartzberg, Pamela L.] NHGRI, Cell Signaling Sect, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
[Strom, Ted] Univ Tennessee, Ctr Hlth Sci, Dept Pathol, Memphis, TN 38163 USA.
[Cleland, Sophia; Nikolov, Nikolay P.; Bailey, Daniel; Siegel, Richard M.] NIAMS, Immunoregulat Grp, Autoimmun Branch, NIH, Bethesda, MD USA.
[Cleland, Sophia] George Washington Univ, Dept Immunol, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 739
EP 740
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300190
ER
PT S
AU Chiodoni, C
Sangaletti, S
Salcedo, R
Tripodo, C
Ratti, C
Gyulai, Z
Nedospasov, S
Trinchieri, G
Colombo, MP
AF Chiodoni, Claudia
Sangaletti, Sabina
Salcedo, Rosalba
Tripodo, Claudio
Ratti, Chiara
Gyulai, Zsofia
Nedospasov, Sergei
Trinchieri, Giorgio
Colombo, Mario P.
BE Wallach, D
Kovalenko, A
Feldman, M
TI LEUKOCYTE-DERIVED TNF-alpha PROMOTES TUMOR GROWTH IN A SPONTANEOUS MODEL
OF MAMMARY CARCINOGENESIS
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Chiodoni, Claudia; Sangaletti, Sabina; Ratti, Chiara; Colombo, Mario P.] Fdn IRCCS Ist Nazl Tumori, Immunotherapy & Gene Therapy Unit, Dept Expt Oncol, I-20133 Milan, Italy.
[Salcedo, Rosalba; Gyulai, Zsofia; Trinchieri, Giorgio] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.
[Tripodo, Claudio] Univ Palermo, Dipartimento Patol Umana, Palermo, Italy.
[Nedospasov, Sergei] Russian Acad Sci, Lab Mol Immunol, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia.
EM sergei.nedospasov@gmail.com
RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015; Tripodo,
Claudio/O-4536-2016; Nedospasov, Sergei/Q-7319-2016
OI Tripodo, Claudio/0000-0002-0821-6231;
NR 0
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 754
EP 755
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300207
ER
PT S
AU McCarthy, DD
Ivanov, II
Tumanov, AV
Shi, H
Koroleva, EP
Summers-DeLuca, L
Ward, LA
Casellas, R
Nedospovav, SA
Fu, YX
Littman, DR
Gommerman, JL
AF McCarthy, Douglas D.
Ivanov, Ivaylo I.
Tumanov, Alexei V.
Shi, Hang
Koroleva, Ekaterina P.
Summers-deLuca, Leslie
Ward, Lesley A.
Casellas, Rafael
Nedospovav, Sergei A.
Fu, Yang-Xin
Littman, Dan R.
Gommerman, Jennifer L.
BE Wallach, D
Kovalenko, A
Feldman, M
TI LYMPHOTOXIN-beta RECEPTOR SIGNALING SUPPORTS A UNIQUE STROMAL CELL NICHE
THAT SUPPORTS IGA CLASS SWITCH RECOMBINATION IN THE INTESTINAL LAMINA
PROPRIA
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [McCarthy, Douglas D.; Shi, Hang; Summers-deLuca, Leslie; Ward, Lesley A.; Gommerman, Jennifer L.] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada.
[Ivanov, Ivaylo I.; Littman, Dan R.] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA.
[Littman, Dan R.] NYU, Sch Med, Howard Hughes Med Inst, Dept Microbiol, New York, NY 10016 USA.
[Littman, Dan R.] NYU, Sch Med, Howard Hughes Med Inst, Dept Pathol, New York, NY 10016 USA.
[Tumanov, Alexei V.; Koroleva, Ekaterina P.; Fu, Yang-Xin] Univ Chicago, Dept Pathol & Immunol, Chicago, IL 60636 USA.
[Casellas, Rafael] NIAMSD, NIH, Bethesda, MD 20892 USA.
[Nedospovav, Sergei A.] Russian Acad Sci, Engelhardt Inst Mol Biol, Lab Mol Immunol, Moscow 119991, Russia.
EM sergei.nedospasov@gmail.com; jen.gommerman@utoronto.ca
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 776
EP 776
PG 1
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300232
ER
PT J
AU Leopold, DA
AF Leopold, David A.
TI What is it like to be a human?
SO COGNITIVE NEUROSCIENCE
LA English
DT Editorial Material
AB The explicit link between awareness and sociality put forward in the accompanying article opens new doors to thinking about the evolutionary origins of consciousness. Human subjective experience undoubtedly has some features that are species-specific and others that are shared over a broad phylogenetic base. The authors' proposal that consciousness depends on high-level neural circuits evolved for social perception begs the question whether animals lacking such circuitry experience a fundamentally different form of consciousness from humans. It also highlights the need for comparative work elucidating neural mechanisms by which animals other than primates perceive and respond to their conspecifics.
C1 NIMH, Unit Cognit Neurophysiol & Imaging, NIH, Bethesda, MD 20892 USA.
RP Leopold, DA (reprint author), NIMH, Unit Cognit Neurophysiol & Imaging, NIH, Bethesda, MD 20892 USA.
EM leopoldd@mail.nih.gov
OI Leopold, David/0000-0002-1345-6360
FU Intramural NIH HHS [ZIA MH002838-07]
NR 0
TC 0
Z9 0
U1 0
U2 1
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1758-8928
J9 COGN NEUROSCI-UK
JI Cogn. Neurosci
PY 2011
VL 2
IS 2
BP 121
EP 122
AR PII 938734921
DI 10.1080/17588928.2011.585235
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA 779UO
UT WOS:000291807900013
PM 22081774
ER
PT B
AU Robbins, JB
Schneerson, R
Szu, SC
Pozsgay, V
AF Robbins, John B.
Schneerson, Rachel
Szu, Shouson C.
Pozsgay, Vince
BE Plotkin, SA
TI Polysaccharide-Protein Conjugate Vaccines
SO HISTORY OF VACCINE DEVELOPMENT
LA English
DT Article; Book Chapter
ID INFLUENZAE TYPE-B; SHIGELLA-DYSENTERIAE TYPE-1; O-SPECIFIC
POLYSACCHARIDE; HEMOPHILUS-INFLUENZAE; CAPSULAR POLYSACCHARIDE;
ANTIBODY-RESPONSES; IMMUNOLOGICAL RESPONSES; SALMONELLA-TYPHIMURIUM;
HUMAN IMMUNITY; AGE INCIDENCE
C1 [Robbins, John B.; Schneerson, Rachel; Szu, Shouson C.; Pozsgay, Vince] NICHHD, NIH, Bethesda, MD 20892 USA.
RP Robbins, JB (reprint author), NICHHD, NIH, Bethesda, MD 20892 USA.
EM robbinsjo@mail.nib.gov
NR 66
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-1338-8
PY 2011
BP 91
EP 102
DI 10.1007/978-1-4419-1339-5_12
D2 10.1007/978-1-4419-1339-5
PG 12
WC Immunology
SC Immunology
GA BVF18
UT WOS:000291365000012
ER
PT J
AU Xu, XH
Xu, MM
Jones, OD
Chen, XZ
Li, YF
Yan, GF
Pan, YX
Davis, HG
Xu, Y
Bryant, JL
Zheng, SE
Anthony, DD
AF Xu, Xuehong
Xu, Mengmeng
Jones, Odell D.
Chen, Xunzhang
Li Yanfei
Yan, Guifang
Pan, Yuexing
Davis, Harry G.
Xu, Yi
Bryant, Joseph L.
Zheng, Shangen
Anthony, Donald D.
TI Liquid Crystal in Lung Development and Chicken Embryogenesis
SO MOLECULAR CRYSTALS AND LIQUID CRYSTALS
LA English
DT Article
DE Embryogenesis; liquid crystal droplet; lung development; phase
transition
ID LIPOID DROPLETS; RECEPTOR; FIBROBLASTS
AB Organogenesis has been given increasing attention in the fields of biomedical and bioengineering. However, the mechanism for a succession process as complex as embryogenesis remains largely unknown. Based on our previous discoveries, liquid crystal may play a crucial role in organogenesis. Here, our results demonstrated that LC droplets were distributed on the pleural area, the bronchus and bronchiole in the developing lung. The lung liquid crystal droplets are capable of phase transitions between liquid crystal, crystal, and isotropic phases which are dependent on the rate of temperature change as previously reported in liver, kidney and other major tissues of the embryo.
C1 [Xu, Xuehong; Chen, Xunzhang; Li Yanfei] Univ Maryland, Sch Med, Ctr Biomed & Engn Technol, Dept Physiol, Baltimore, MD 21201 USA.
[Xu, Xuehong] Wuhan Univ, Sch Life Sci, Wuhan 430072, Peoples R China.
[Xu, Mengmeng] Univ Maryland, Dept Chem & Biochem, Gemstone Program, College Pk, MD 20742 USA.
[Xu, Mengmeng] Johns Hopkins Univ Hosp, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
[Jones, Odell D.; Davis, Harry G.; Bryant, Joseph L.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA.
[Chen, Xunzhang; Li Yanfei; Zheng, Shangen] Gen Hosp, Wuhan, Peoples R China.
[Yan, Guifang] Johns Hopkins Univ Hosp, Sch Med, Dept Urol, Baltimore, MD 21205 USA.
[Pan, Yuexing; Anthony, Donald D.] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA.
[Xu, Yi] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Detroit, MI USA.
RP Xu, XH (reprint author), Univ Maryland, Sch Med, Ctr Biomed & Engn Technol, Dept Physiol, Baltimore, MD 21201 USA.
EM xxu@umarylamd.edu
NR 35
TC 2
Z9 2
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1542-1406
J9 MOL CRYST LIQ CRYST
JI Mol. Cryst. Liquid Cryst.
PY 2011
VL 547
SI SI
BP 164
EP 172
AR PII 938730031
DI 10.1080/15421406.2011.572042
PG 9
WC Crystallography
SC Crystallography
GA 780MN
UT WOS:000291861400020
ER
PT J
AU Xu, MM
Jones, OD
Zheng, SE
Li, YF
Yan, GF
Pan, YX
Davis, HG
Anthony, DD
Xu, Y
Bryant, JL
Xu, XH
AF Xu, Mengmeng
Jones, Odell D.
Zheng, Shangen
Li Yanfei
Yan, Guifang
Pan, Yuexing
Davis, Harry G.
Anthony, Donald D.
Xu, Yi
Bryant, Joseph L.
Xu, Xuehong
TI Cytoplasmic Accumulation of Liquid-Crystal Like Droplets in
Post-Infection Sputum Generated by Gram-Positive Bacteria
SO MOLECULAR CRYSTALS AND LIQUID CRYSTALS
LA English
DT Article
DE Gram-positive sputum; liquid-crystal like droplets; monocyte; squamous
epithelial cell
ID ANDERSON-FABRY-DISEASE; MACULAR DEGENERATION; FIBROBLASTS; RECEPTOR;
VARIANT
AB Massive liquid crystal droplets (LCDs) have been reported in early embryogenesis and implicated in pathological progression of human diseases. The presence of LCDs has even been established as an effective diagnostic hallmark of Fabry-Anderson's disease. In this study, we report the presence of LCDs, identified by established thermal stage phase transition methods, in sputum collected during the recovery phase of respiratory infection by gram-positive bacteria. This finding provides additional insight on the breadth of liquid crystal presence in human pathology. Further study on the formation of these LCDs may lead to new perspectives on post-infection removal of infectious agents.
C1 [Li Yanfei; Xu, Xuehong] Univ Maryland, Sch Med, Dept Physiol, Ctr Biomed & Engn Technol, Baltimore, MD 21201 USA.
[Xu, Mengmeng] Duke Univ, Sch Med, MSTP Program, Durham, NC USA.
[Xu, Mengmeng] Johns Hopkins Univ Hosp, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
[Jones, Odell D.; Davis, Harry G.; Bryant, Joseph L.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA.
[Zheng, Shangen; Li Yanfei] Gen Hosp, Wuhan, Peoples R China.
[Yan, Guifang] Johns Hopkins Univ Hosp, Sch Med, Dept Urol, Baltimore, MD 21205 USA.
[Pan, Yuexing; Anthony, Donald D.] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA.
[Xu, Yi] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Detroit, MI USA.
[Xu, Xuehong] Wuhan Univ, Sch Life Sci, Wuhan 430072, Peoples R China.
RP Xu, XH (reprint author), Univ Maryland, Sch Med, Dept Physiol, Ctr Biomed & Engn Technol, Baltimore, MD 21201 USA.
EM xxu@umarylamd.edu
FU TEDCO MD Stem Cell Research Fund; American Heart Association
FX This work is supported by the TEDCO MD Stem Cell Research Fund and
American Heart Association.
NR 23
TC 2
Z9 2
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1542-1406
J9 MOL CRYST LIQ CRYST
JI Mol. Cryst. Liquid Cryst.
PY 2011
VL 547
SI SI
BP 173
EP 180
AR PII 938726675
DI 10.1080/15421406.2011.572045
PG 8
WC Crystallography
SC Crystallography
GA 780MN
UT WOS:000291861400021
ER
PT J
AU Cao, JJ
Prisinzano, TE
Okunola, OM
Kopajtic, T
Shook, M
Katz, JL
Newman, AH
AF Cao, Jianjing
Prisinzano, Thomas E.
Okunola, Oluyomi M.
Kopajtic, Theresa
Shook, Matthew
Katz, Jonathan L.
Newman, Amy Hauck
TI SARs at the Monoamine Transporters for a Novel Series of Modafinil
Analogues
SO ACS MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE SAR; monoamine transporters; modafinil analogues
ID DOPAMINE UPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND;
IN-VIVO; COCAINE; ARMODAFINIL; DEPENDENCE; COGNITION; POTENT
AB A series of modafinil (1) analogues were synthesized wherein (1) para-halo substitutents were added to the aryl rings, (2) the sulfoxide function was removed, and (3) the primary amide group was replaced with secondary and tertiary amides and amines to investigate the effects of these chemical modifications on dopamine transporter, serotonin transporter, and norepinephrine transporter binding. In addition, the locomoter-stimulant effects in mice of (+/-) modafinil (1), its R- and S-enantiomers, and its para-chloro sulfinylacetamide analogue (5c) were compared to those of cocaine.
C1 [Cao, Jianjing; Okunola, Oluyomi M.; Newman, Amy Hauck] NIDA, Med Chem Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
[Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.] NIDA, Psychobiol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
[Prisinzano, Thomas E.] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA.
RP Newman, AH (reprint author), NIDA, Med Chem Sect, Intramural Res Program, NIH, 333 Cassell Dr, Baltimore, MD 21224 USA.
EM anewman@intra.nida.nih.gov
OI Katz, Jonathan/0000-0002-1068-1159
FU NIDA-IRP; NIH
FX This work was funded by the NIDA-IRP. O.M.O. was supported by a NIH
Postdoctoral Intramural Research Training Award (IRTA) Fellowship. M.S.
was supported by the NIH Summer Internship Program.
NR 30
TC 16
Z9 17
U1 5
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-5875
J9 ACS MED CHEM LETT
JI ACS Med. Chem. Lett.
PD JAN
PY 2011
VL 2
IS 1
BP 48
EP 52
DI 10.1021/ml1002025
PG 5
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 707SL
UT WOS:000286306200010
PM 21344069
ER
PT J
AU Greene, MH
Mai, PL
Schwartz, PE
AF Greene, Mark H.
Mai, Phuong L.
Schwartz, Peter E.
TI Does bilateral salpingectomy with ovarian retention warrant
consideration as a temporary bridge to risk-reducing bilateral
oophorectomy in BRCA1/2 mutation carriers?
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE bilateral oophorectomy; bilateral salpingectomy; BRCA1/2 mutation
carrier; ovarian cancer risk; risk-reducing surgery
ID PELVIC SEROUS CARCINOMA; PROPHYLACTIC OOPHORECTOMY; CANCER RISK;
BREAST-CANCER; FALLOPIAN-TUBE; FOLLOW-UP; INTRAEPITHELIAL CARCINOMA;
PATHOLOGICAL FINDINGS; TALC-USE; WOMEN
AB Risk-reducing salpingo-oophorectomy (RRSO) is the most definitive surgical intervention for ovarian cancer risk reduction among BRCA1/2 mutation carriers. For women who have completed child-bearing but who are not ready for RRSO, bilateral salpingectomy with ovarian retention (BSOR) might serve as a temporary measure while definitive risk-reducing surgery is being contemplated. Here we summarize recent insights into the pathogenesis of hereditary ovarian cancer that might provide a basis for consideration of the proposed BSOR management strategy and outline the evidence for and against this potential risk-reducing intervention. Based on the evidence, we suggest that there may be sufficient merit in this proposed intervention to consider evaluating it formally, perhaps through an intergroup-based clinical trial. In the meanwhile, we believe that BSOR should be considered an investigational risk management option of unproven clinical usefulness, particularly because delay in bilateral oophorectomy theoretically could reduce the protective effect against breast cancer that has been documented in women who have undergone RRSO.
C1 [Greene, Mark H.; Mai, Phuong L.] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA.
[Schwartz, Peter E.] Yale Univ, Sch Med, Div Gynecol Oncol, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA.
RP Greene, MH (reprint author), NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA.
FU Intramural NIH HHS [ZIA CP010145-11]
NR 44
TC 4
Z9 5
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
IS 1
AR 19.e1
DI 10.1016/j.ajog.2010.05.038
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 698VU
UT WOS:000285622500008
PM 20619389
ER
PT J
AU Rodriguez, AC
Schiffman, M
Herrero, R
Hildesheim, A
Wacholder, S
Burk, RD
AF Cecilia Rodriguez, Ana
Schiffman, Mark
Herrero, Rolando
Hildesheim, Allan
Wacholder, Sholom
Burk, Robert D.
TI Re: Longitudinal Study of Human Papillomavirus Persistence and Cervical
Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of
Infection, Response
SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Letter
ID PARTICLE VACCINE; YOUNG-WOMEN; TRIAL
C1 [Cecilia Rodriguez, Ana; Herrero, Rolando] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica.
[Schiffman, Mark] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA.
[Hildesheim, Allan] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA.
[Wacholder, Sholom] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA.
[Burk, Robert D.] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.
RP Rodriguez, AC (reprint author), Fdn INCIENSA, Proyecto Epidemiol Guanacaste, 7mo Piso, San Jose, Costa Rica.
EM acrodriguez@racsa.co.cr
RI Hildesheim, Allan/B-9760-2015
OI Hildesheim, Allan/0000-0003-0257-2363
NR 7
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
EI 1460-2105
J9 JNCI-J NATL CANCER I
JI JNCI-J. Natl. Cancer Inst.
PD JAN
PY 2011
VL 103
IS 2
DI 10.1093/jnci/djq485
PG 2
WC Oncology
SC Oncology
GA 709WT
UT WOS:000286472800013
ER
PT J
AU Wacholder, S
Han, SS
Weinberg, CR
AF Wacholder, Sholom
Han, Summer S.
Weinberg, Clarice R.
TI Inference From a Multiplicative Model of Joint Genetic Effects or
Ovarian Cancer Risk
SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Editorial Material
ID ASHKENAZI JEWISH CARRIERS; GENOME-WIDE ASSOCIATION; MULTISTAGE
CARCINOGENESIS; BRCA2 MUTATIONS; BLADDER-CANCER
C1 [Wacholder, Sholom; Han, Summer S.] NCI, Div Canc Epidemiol & Genet, Biostat Branch, Bethesda, MD 20892 USA.
[Weinberg, Clarice R.] NIEHS, Biostat Branch, Res Triangle Pk, NC 27709 USA.
RP Wacholder, S (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,EPS 5050,MSC-7244, Rockville, MD 20892 USA.
EM Wacholds@mail.nih.gov
NR 11
TC 1
Z9 1
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
EI 1460-2105
J9 JNCI-J NATL CANCER I
JI JNCI-J. Natl. Cancer Inst.
PD JAN
PY 2011
VL 103
IS 2
DI 10.1093/jnci/djq510
PG 2
WC Oncology
SC Oncology
GA 709WT
UT WOS:000286472800002
ER
PT J
AU Kriegel, C
Koehne, J
Tinkle, S
Maynard, AD
Hill, RA
AF Kriegel, Christina
Koehne, Jessica
Tinkle, Sally
Maynard, Andrew D.
Hill, Rodney A.
TI Challenges of Trainees in a Multidisciplinary Research Program:
Nano-Biotechnology
SO JOURNAL OF CHEMICAL EDUCATION
LA English
DT Article
C1 [Koehne, Jessica] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA.
[Koehne, Jessica] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
[Tinkle, Sally] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Risk Sci Ctr, Ann Arbor, MI 48109 USA.
[Hill, Rodney A.] Univ Idaho, Dept Anim & Vet Sci, Moscow, ID 83844 USA.
[Kriegel, Christina] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.
RP Kriegel, C (reprint author), Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA.
EM rodhill@uidaho.edu
OI Maynard, Andrew/0000-0003-2117-5128
NR 12
TC 1
Z9 1
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-9584
J9 J CHEM EDUC
JI J. Chem. Educ.
PD JAN
PY 2011
VL 88
IS 1
BP 53
EP 55
DI 10.1021/ed1001174
PG 3
WC Chemistry, Multidisciplinary; Education, Scientific Disciplines
SC Chemistry; Education & Educational Research
GA 694WE
UT WOS:000285328900014
ER
PT J
AU Sztein, JM
AF Sztein, Jorge M.
TI Ovarian transplant for transgenic rescue
SO LAB ANIMAL
LA English
DT Letter
ID MOUSE OVARIES; MICE; LINE
C1 NIAID, Cryopreservat Unit, NIH, Rockville, MD USA.
RP Sztein, JM (reprint author), NIAID, Cryopreservat Unit, NIH, Rockville, MD USA.
EM szteinj@niaid.nih.gov
OI Sztein, Jorge Mario/0000-0001-7047-2634
NR 10
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0093-7355
J9 LAB ANIMAL
JI Lab Anim.
PD JAN
PY 2011
VL 40
IS 1
BP 9
EP 9
DI 10.1038/laban0111-9a
PG 1
WC Veterinary Sciences
SC Veterinary Sciences
GA 700KM
UT WOS:000285737700012
PM 21173762
ER
PT J
AU McMahon, FJ
Akula, N
Cichon, S
Detera-Wadleigh, SD
Edenberg, H
Holsboer, F
Nothen, MM
Nurnberger, JI
Potash, J
Preisig, M
Rietschel, M
Schulze, TG
AF McMahon, Francis J.
Akula, Nirmala
Cichon, Sven
Detera-Wadleigh, Sevilla D.
Edenberg, Howard
Holsboer, Florian
Noethen, Markus M.
Nurnberger, John I.
Potash, James
Preisig, Martin
Rietschel, Marcella
Schulze, Thomas G.
TI Replication of association of 3p21.1 with susceptibility to bipolar
disorder but not major depression Reply
SO NATURE GENETICS
LA English
DT Letter
ID GENOME-WIDE ASSOCIATION
C1 [McMahon, Francis J.; Akula, Nirmala; Detera-Wadleigh, Sevilla D.; Schulze, Thomas G.] NIMH, Genet Basis Mood & Anxiety Disorders Sect, NIH, US Dept HHS, Bethesda, MD 20892 USA.
[Cichon, Sven; Noethen, Markus M.] Univ Bonn, Life & Brain Ctr, Dept Genom, D-5300 Bonn, Germany.
[Cichon, Sven; Noethen, Markus M.] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany.
[Edenberg, Howard; Nurnberger, John I.] Indiana Univ Purdue Univ, Indianapolis, IN 46202 USA.
[Holsboer, Florian] Max Planck Inst Psychiat, D-80804 Munich, Germany.
[Potash, James] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
[Preisig, Martin] Univ Hosp Ctr, Lausanne, Switzerland.
[Preisig, Martin] Univ Lausanne, Dept Psychiat, Lausanne, Switzerland.
[Rietschel, Marcella; Schulze, Thomas G.] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany.
[Schulze, Thomas G.] Univ Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.
RP McMahon, FJ (reprint author), NIMH, Genet Basis Mood & Anxiety Disorders Sect, NIH, US Dept HHS, Bethesda, MD 20892 USA.
EM mcmahonf@mail.nih.gov
RI Schulze, Thomas/H-2157-2013; Cichon, Sven/H-8803-2013; Cichon,
Sven/B-9618-2014;
OI Cichon, Sven/0000-0002-9475-086X; Cichon, Sven/0000-0002-9475-086X;
McMahon, Francis/0000-0002-9469-305X
NR 6
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD JAN
PY 2011
VL 43
IS 1
BP 5
EP 5
DI 10.1038/ng0111-5
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA 699SQ
UT WOS:000285683500003
ER
PT J
AU Patrick, H
Canevello, A
AF Patrick, Heather
Canevello, Amy
TI Methodological overview of a self-determination theory-based
computerized intervention to promote leisure-time physical activity
SO PSYCHOLOGY OF SPORT AND EXERCISE
LA English
DT Article
DE Computerized intervention; Self-determination theory; Autonomy support;
Personal trainers; Physical activity
ID AUTONOMY SUPPORT; INTRINSIC MOTIVATION; EHEALTH INTERVENTIONS; SMOKING
CESSATION; EXERCISE; SPORT; STYLE; BEHAVIORS; MODEL; RISK
AB Objectives: To provide a methodological overview of a computerized intervention to promote leisure-time physical activity (PA) and to apply self-determination theory (SDT) to PA initiation to better understand the psychological mechanisms underlying PA frequency, intensity, and duration in previously-sedentary individuals.
Design: Based on SDT, two computerized personal trainers were developed for use with sedentary young adults. One personal trainer was designed to be need-supportive, empathic, and structured while the other was designed to be more controlling, evaluative, and judgmental.
Method: Participants are randomly assigned to work with either the need-supportive or controlling computerized personal trainer. They complete a series of 7 weekly training sessions. In between training sessions, participants complete daily records of PA behaviors and experiences including autonomous self-regulation and perceived competence for PA and PA frequency, intensity, and duration.
Potential contributions: The design of this intervention and its theoretical basis have important implications for advancing the field of exercise science specifically and health behavior change more broadly. Computerized interventions have the benefit of standardizing intervention content as well as reducing clinical contact burden for practitioners. Daily recording procedures reduce the likelihood of retrospection bias and allow for the modeling of (1) daily fluctuations in PA behavior and (2) the psychological mechanisms believed to be involved in PA behavior (e.g., autonomous self-regulation). Finally, as a broad theory of human motivation, SOT is uniquely positioned to offer explanations for the conditions that are likely to promote both the initiation and maintenance of health behavior change. Published by Elsevier Ltd.
C1 [Patrick, Heather] Univ Rochester, Dept Med, Rochester, NY USA.
[Patrick, Heather] Univ Rochester, Dept Clin & Social Psychol, Rochester, NY USA.
[Canevello, Amy] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
RP Patrick, H (reprint author), NCI, DCCPS BRP HPRB, 6130 Execut Blvd,EPN Room 4076,MSC 7335, Rockville, MD 20852 USA.
EM patrickha@gmail.nih.gov
FU National Cancer Institute [R21 CA 109961]
FX This research was supported by R21 CA 109961 from the National Cancer
Institute to the first author while she was at Baylor College of
Medicine and, subsequently the University of Rochester.
NR 75
TC 12
Z9 12
U1 8
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1469-0292
J9 PSYCHOL SPORT EXERC
JI Psychol. Sport Exerc.
PD JAN
PY 2011
VL 12
IS 1
BP 13
EP 19
DI 10.1016/j.psychsport.2010.04.011
PG 7
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA 693OE
UT WOS:000285232600003
PM 21103069
ER
PT J
AU Le, K
Coelho, C
Mozeiko, J
Krueger, F
Grafman, J
AF Le, Karen
Coelho, Carl
Mozeiko, Jennifer
Krueger, Frank
Grafman, Jordan
TI Measuring goodness of story narratives: Implications for traumatic brain
injury
SO APHASIOLOGY
LA English
DT Article; Proceedings Paper
CT 40th Clinical Aphasiology Conference (CAC)
CY MAY 23-27, 2010
CL Isle of Palms, SC
DE Discourse production; Narrative discourse; Traumatic brain injury;
Discourse analysis; Penetrating head injury; Story narratives
ID CLOSED-HEAD-INJURY; PRAGMATIC LANGUAGE-SKILLS; DISCOURSE PRODUCTION;
WORKING-MEMORY; CHILDREN; ADULTS; COMPREHENSION; ABILITY; NEEDS
AB Background: This study examined the utility of story ogoodnesso, a measure of organisation and completeness, in quantifying narrative discourse deficits following traumatic brain injury (TBI). In an initial study, the story goodness measure demonstrated sensitivity and reliability in distinguishing individuals who had TBI from those who were non-brain-injured. Aims: The purpose of the current study was to validate previous findings of the story goodness index, specifically in discriminating performance between groups and identifying performance subgroups, in a larger sample of participants with TBI. Methods Procedures: A total of 46 non-brain-injured adults and 171 adults with TBI participated. Story retellings were analysed for story grammar and story completeness. The two discourse scores were then plotted as coordinates, which allowed for quantification of story goodness. Statistical analyses included a multivariate analysis of variance and calculation of Pearson correlation coefficients for the discourse measures. Outcomes Results: Results indicated that participants' scores clustered differentially across quadrants between groups and discriminated groups into four distinct categories of story ogoodnesso. Conclusions: Findings paralleled those found in the initial study, suggesting that story goodness is a sensitive measure for examining the discourse of individuals with TBI. The story goodness has potential clinical utility and may have implications for investigation of discourse impairments in other clinical populations and treatment of discourse deficits.
C1 [Grafman, Jordan] NINDS, Cognit Neurosci Sect, Magnuson Clin Ctr, Bethesda, MD 20892 USA.
[Le, Karen; Coelho, Carl; Mozeiko, Jennifer] Univ Connecticut, Dept Commun Sci, Storrs, CT 06268 USA.
RP Grafman, J (reprint author), NINDS, Cognit Neurosci Sect, Magnuson Clin Ctr, Bldg 10,7D43,MSC 1440,10 Ctr Dr, Bethesda, MD 20892 USA.
EM GrafmanJ@ninds.nih.gov
OI Grafman, Jordan H./0000-0001-8645-4457
NR 30
TC 7
Z9 7
U1 4
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0268-7038
EI 1464-5041
J9 APHASIOLOGY
JI Aphasiology
PY 2011
VL 25
IS 6-7
BP 748
EP 760
AR PII 938548156
DI 10.1080/02687038.2010.539696
PG 13
WC Clinical Neurology
SC Neurosciences & Neurology
GA 775XO
UT WOS:000291497000008
ER
PT J
AU Mozeiko, J
Le, K
Coelho, C
Krueger, F
Grafman, J
AF Mozeiko, Jennifer
Le, Karen
Coelho, Carl
Krueger, Frank
Grafman, Jordan
TI The relationship of story grammar and executive function following TBI
SO APHASIOLOGY
LA English
DT Article; Proceedings Paper
CT 40th Clinical Aphasiology Conference (CAC)
CY MAY 23-27, 2010
CL Isle of Palms, SC
DE Traumatic brain injury; penetrating head injury; Discourse analysis;
narrative discourse; Story grammar; Executive function
ID TRAUMATIC BRAIN-INJURY; DEFICITS; ADULTS
AB Background: Story grammar is a super-structural measure of discourse performance that has shown to be sensitive to the deficits seen following traumatic brain injury (TBI). Narrative organisation and identification of logical relationships between events and characters are key components of story grammar. Reports of significant correlations for measures of story grammar and scores from various tests of executive functioning for individuals with TBI are thought to reflect executive control of cognitive and linguistic organisational processes. Aims: The purpose of the present study was to re-examine the relationship between story grammar and executive functions (EF) in a large group of participants with severe TBI secondary to diverse penetrating head wounds. It was hypothesised that participants with TBI would have significantly lower story grammar scores than a comparison group without TBI, and that story grammar performance of the group with TBI would be significantly correlated with their EF scores. Methods Procedures: A total of 167 participants with TBI and a comparison group of 46 adults without TBI were asked to retell a 16-frame story. Transcripts of each story retelling were broken into T-units and were analysed for story grammar. Outcomes Results: Results of MANOVA showed significant effect of group on the discourse measures. Univariate tests showed significant differences between the group with TBI and the comparison group for each of the story grammar measures. Story grammar measures were significantly correlated with executive function (EF) scores. Conclusions: Results indicated that the participants with TBI demonstrated significantly poorer performance on measures of story grammar abilities, lending support to earlier reports of story grammar impairments resulting from closed head injury (CHI). The present study also found significant correlations for measures of story grammar and the Sorting Test. Cognitive skills such as mental flexibility, required for successful performance on this card sorting task are likely the same as those required for episode generation. These findings have clinical implications for the management of cognitive-communication disorders in individuals with TBI. First, story grammar warrants inclusion in analyses of discourse. Second, discourse deficits following brain injury do not resolve spontaneously and persist as social barriers.
C1 [Mozeiko, Jennifer; Le, Karen; Coelho, Carl] Univ Connecticut, Dept Commun Disorders, Storrs, CT USA.
[Krueger, Frank; Grafman, Jordan] NINDS, Cognit Neurosci Sect, Bethesda, MD 20892 USA.
RP Grafman, J (reprint author), Kessler Fdn Res Ctr, Traumat Brain Injury Res Lab, 1199 Pleasant Valley Way, W Orange, NJ 07052 USA.
EM jgrafman@kesslerfoundation.org
OI Grafman, Jordan H./0000-0001-8645-4457
NR 28
TC 14
Z9 14
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0268-7038
EI 1464-5041
J9 APHASIOLOGY
JI Aphasiology
PY 2011
VL 25
IS 6-7
BP 826
EP 835
AR PII 934165989
DI 10.1080/02687038.2010.543983
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 775XO
UT WOS:000291497000014
ER
PT J
AU Lee, K
Kang, SG
Liu, XF
Seo, D
AF Lee, Keunbaik
Kang, Sanggil
Liu, Xuefeng
Seo, Daekwan
TI Likelihood-based approach for analysis of longitudinal nominal data
using marginalized random effects models
SO JOURNAL OF APPLIED STATISTICS
LA English
DT Article
DE likelihood-based model; random effects; marginal model; Quasi-Newton;
Kronecker product
ID LOGISTIC-NORMAL MODELS; BINARY DATA; REGRESSION-MODEL; CATEGORICAL-DATA;
ORDINAL DATA; INFERENCE
AB Likelihood-based marginalized models using random effects have become popular for analyzing longitudinal categorical data. These models permit direct interpretation of marginal mean parameters and characterize the serial dependence of longitudinal outcomes using random effects [12,22]. In this paper, we propose model that expands the use of previous models to accommodate longitudinal nominal data. Random effects using a new covariance matrix with a Kronecker product composition are used to explain serial and categorical dependence. The Quasi-Newton algorithm is developed for estimation. These proposed methods are illustrated with a real data set and compared with other standard methods.
C1 [Lee, Keunbaik] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA 70122 USA.
[Kang, Sanggil] Sangji Univ, Dept Data Informat, Wonju, South Korea.
[Liu, Xuefeng] E Tennessee State Univ, Coll Publ Hlth, Dept Biostat & Epidemiol, Johnson City, TN 37614 USA.
[Seo, Daekwan] NCI, Expt Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA.
RP Lee, K (reprint author), Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA 70122 USA.
EM klee4@lsuhsc.edu
NR 34
TC 4
Z9 4
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0266-4763
EI 1360-0532
J9 J APPL STAT
JI J. Appl. Stat.
PY 2011
VL 38
IS 8
BP 1577
EP 1590
DI 10.1080/02664763.2010.515675
PG 14
WC Statistics & Probability
SC Mathematics
GA 775MU
UT WOS:000291464400003
ER
PT S
AU Bi, M
Summers, RM
Yao, JH
AF Bi, Mark
Summers, Ronald M.
Yao, Jianhua
BE Weaver, JB
Molthen, RC
TI 3-Dimensional Automatic Computer-Aided Evaluation of Pleural Effusions
on Chest CT Images
SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL,
AND FUNCTIONAL IMAGING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Biomedical Applications in
Molecular, Structural, and Functional Imaging
CY FEB 13-16, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc
DE pleural effusion; chest CT
AB The ability to estimate the volume of pleural effusions is desirable as it can provide information about the severity of the condition and the need for thoracentesis. We present here an improved version of an automated program to measure the volume of pleural effusions using regular chest CT images. First, the lungs are segmented using region growing, mathematical morphology, and anatomical knowledge. The visceral and parietal layers of the pleura are then extracted based on anatomical landmarks, curve fitting and active contour models. The liver and compressed tissues are segmented out using thresholding. The pleural space is then fitted to a Bezier surface which is subsequently projected onto the individual two-dimensional slices. Finally, the volume of the pleural effusion is quantified. Our method was tested on 15 chest CT studies and validated against three separate manual tracings. The Dice coefficients were 0.74+/-0.07, 0.74+/-0.08, and 0.75+/-0.07 respectively, comparable to the variation between two different manual tracings.
C1 [Bi, Mark; Summers, Ronald M.; Yao, Jianhua] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Bi, M (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
EM jyao@cc.nih.gov
NR 5
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-507-6
J9 PROC SPIE
PY 2011
VL 7965
AR 79651W
DI 10.1117/12.878047
PG 7
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Imaging Science & Photographic Technology;
Radiology, Nuclear Medicine & Medical Imaging
GA BVF69
UT WOS:000291388700064
ER
PT S
AU Pura, JA
Hamilton, AM
Vargish, GA
Butman, JA
Linguraru, MG
AF Pura, John A.
Hamilton, Allison M.
Vargish, Geoffrey A.
Butman, John A.
Linguraru, Marius George
BE Weaver, JB
Molthen, RC
TI Automated Segmentation of Ventricles from Serial Brain MRI for the
Quantification of Volumetric Changes Associated with Communicating
Hydrocephalus in Patients with Brain Tumor
SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL,
AND FUNCTIONAL IMAGING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Biomedical Applications in
Molecular, Structural, and Functional Imaging
CY FEB 13-16, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc
DE Brain imaging; MRI; brain tumor; communicating hydrocephalus;
segmentation; monitoring
ID NONRIGID REGISTRATION; IMAGES; EXTRACTION; ROBUST
AB Accurate ventricle volume estimates could improve the understanding and diagnosis of postoperative communicating hydrocephalus. For this category of patients, associated changes in ventricle volume can be difficult to identify, particularly over short time intervals. We present an automated segmentation algorithm that evaluates ventricle size from serial brain MRI examination. The technique combines serial T1-weighted images to increase SNR and segments the means image to generate a ventricle template. After pre-processing, the segmentation is initiated by a fuzzy c-means clustering algorithm to find the seeds used in a combination of fast marching methods and geodesic active contours. Finally, the ventricle template is propagated onto the serial data via non-linear registration. Serial volume estimates were obtained in an automated robust and accurate manner from difficult data.
C1 [Pura, John A.; Hamilton, Allison M.; Vargish, Geoffrey A.; Butman, John A.; Linguraru, Marius George] NIH, Ctr Clin, Bethesda, MD 20892 USA.
RP Pura, JA (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA.
EM lingurarum@mail.nih.gov
RI Butman, John/J-2780-2013
OI Butman, John/0000-0002-1547-9195
NR 17
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-507-6
J9 PROC SPIE
PY 2011
VL 7965
AR 79650P
DI 10.1117/12.877679
PG 8
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Imaging Science & Photographic Technology;
Radiology, Nuclear Medicine & Medical Imaging
GA BVF69
UT WOS:000291388700023
ER
PT S
AU Yao, JH
Sussman, DL
Summers, RM
AF Yao, Jianhua
Sussman, Daniel L.
Summers, Ronald M.
BE Weaver, JB
Molthen, RC
TI Fully Automated Adipose Tissue Measurement on Abdominal CT
SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL,
AND FUNCTIONAL IMAGING
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Medical Imaging 2011 - Biomedical Applications in
Molecular, Structural, and Functional Imaging
CY FEB 13-16, 2011
CL Lake Buena Vista, FL
SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc
DE subcutaneous adipose tissue; visceral adipose tissue; abdominal CT
ID BODY-COMPOSITION
AB Obesity has become widespread in America and has been associated as a risk factor for many illnesses. Adipose tissue (AT) content, especially visceral AT (VAT), is an important indicator for risks of many disorders, including heart disease and diabetes. Measuring adipose tissue (AT) with traditional means is often unreliable and inaccurate. CT provides a means to measure AT accurately and consistently. We present a fully automated method to segment and measure abdominal AT in CT. Our method integrates image preprocessing which attempts to correct for image artifacts and inhomogeneities. We use fuzzy c-means to cluster AT regions and active contour models to separate subcutaneous and visceral AT. We tested our method on 50 abdominal CT scans and evaluated the correlations between several measurements.
C1 [Yao, Jianhua; Sussman, Daniel L.; Summers, Ronald M.] NIH, Ctr Clin, Radiol & Imaging Sci Dept, Bethesda, MD 20892 USA.
RP Yao, JH (reprint author), NIH, Ctr Clin, Radiol & Imaging Sci Dept, Bethesda, MD 20892 USA.
EM jyao@cc.nih.gov
NR 13
TC 4
Z9 4
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-507-6
J9 PROC SPIE
PY 2011
VL 7965
AR 79651Z
DI 10.1117/12.878063
PG 6
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Optics; Imaging Science & Photographic Technology;
Radiology, Nuclear Medicine & Medical Imaging
GA BVF69
UT WOS:000291388700067
ER
PT S
AU Ptak, K
Farrell, D
Hinkal, G
Panaro, NJ
Hook, S
Grodzinski, P
AF Ptak, Krzysztof
Farrell, Dorothy
Hinkal, George
Panaro, Nicholas J.
Hook, Sara
Grodzinski, Piotr
BE George, T
Islam, MS
Dutta, AK
TI Cancer Nanotechnology: a new commercialization pipeline for diagnostics,
imaging agents and therapies
SO MICRO- AND NANOTECHNOLOGY SENSORS, SYSTEMS, AND APPLICATIONS III
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Micro- and Nanotechnology Sensors, Systems, and
Applications III
CY APR 25-29, 2011
CL Orlando, FL
SP SPIE
DE nanotechnology; oncology; imaging; diagnostic; treatment;
multidisciplinary research team
ID TARGETED NANOPARTICLES; TOMOSYNTHESIS; DESIGN; FIELD
AB Nanotechnology - the science and engineering of manipulating matter at the molecular scale to create devices with novel chemical, physical and biological properties - has the potential to radically change oncology. Research sponsored by the NCI Alliance for Nanotechnology in Cancer has led to the development of nanomaterials as platforms of increasing complexity and devices of superior sensitivity, speed and multiplexing capability. Input from clinicians has guided researchers in the design of technologies to address specific needs in the areas of cancer therapy and therapeutic monitoring, in vivo imaging, and in vitro diagnostics. The promising output from the Alliance has led to many new companies being founded to commercialize their nanomedical product line. Furthermore, several of these technologies, which are discussed in this paper, have advanced to clinically testing.
C1 [Ptak, Krzysztof; Farrell, Dorothy; Hinkal, George; Hook, Sara; Grodzinski, Piotr] NCI, Off Canc Nanotechnol Res, Ctr Strateg Sci Initiat, Off Director,NIH, Bethesda, MD 20892 USA.
RP Ptak, K (reprint author), NCI, Off Canc Nanotechnol Res, Ctr Strateg Sci Initiat, Off Director,NIH, 31 Ctr Dr, Bethesda, MD 20892 USA.
NR 14
TC 0
Z9 0
U1 1
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-81948-605-9
J9 PROC SPIE
PY 2011
VL 8031
AR 80311S
DI 10.1117/12.884607
PG 11
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Optics
SC Engineering; Science & Technology - Other Topics; Optics
GA BVG10
UT WOS:000291441400056
ER
PT J
AU Niu, SQ
Ichiye, T
AF Niu, Shuqiang
Ichiye, Toshiko
TI Density functional theory calculations of redox properties of
iron-sulphur protein analogues
SO MOLECULAR SIMULATION
LA English
DT Article
DE density functional theory; iron-sulphur protein; reduction potential;
inner-sphere free energy; reorganisation energy
ID EXCHANGE-CORRELATION FUNCTIONALS; ELECTRON-TRANSFER REACTIONS;
TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; CUBANE 4FE-4S
CLUSTER; PHOTOELECTRON-SPECTROSCOPY; ACTIVE-SITES; BASIS-SETS;
MOLECULAR-DYNAMICS; CLOSTRIDIUM-PASTEURIANUM
AB Acentral issue in understanding redox properties of iron-sulphur (Fe-S) proteins is determining the factors that tune the reduction potentials of the Fe-S clusters. Studies of redox site analogues play an important role, particularly because individual factors can be examined independently of the environment by combining calculations and experiments of carefully designed ligands for the analogues. For iron-sulphur analogues, our study has shown that broken-symmetry density functional theory gives good energetics when the geometry is optimised using B3LYP with a double-zeta basis set with polarisation functions, and the energies of these geometries are calculated using B3LYP with additional diffuse functions added to the sulphurs. A comparison of our calculated energies for redox site analogues in the gas phase against electron detachment energies measured by a combination of electrospray ionisation and photoelectron spectroscopy (EI-PES) by Wang and co-workers has been essential because the comparison is for exactly the same molecule with no approximation for the environment. Overall, the correlation of our B3LYP/6-31(++)(S)G**//B3LYP/6-31G** detachment energies with EI-PES experiments is excellent for a wide variety of analogues. Moreover, our calculations at this level have provided insight into a wide variety of properties of iron-sulphur proteins.
C1 [Niu, Shuqiang; Ichiye, Toshiko] Georgetown Univ, Dept Chem, Washington, DC 20057 USA.
[Ichiye, Toshiko] NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA.
RP Ichiye, T (reprint author), Georgetown Univ, Dept Chem, Washington, DC 20057 USA.
EM ti9@georgetown.edu
FU National Institutes of Health [GM-45303]; US DOE Office of Biological
and Environmental Research and located at Pacific Northwest National
Laboratory [GC3565, GC20901, EMSL38793]
FX This study was supported by a grant from the National Institutes of
Health (GM-45303). The calculations were performed at the EMSL, a
national user facility sponsored by the US DOE's Office of Biological
and Environmental Research and located at Pacific Northwest National
Laboratory, operated for DOE by Battelle, under the grant GC3565,
GC20901 and EMSL38793. Additional computational resources were provided
by the William G. McGowan Foundation.
NR 116
TC 8
Z9 8
U1 1
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0892-7022
J9 MOL SIMULAT
JI Mol. Simul.
PY 2011
VL 37
IS 7
BP 572
EP 590
DI 10.1080/08927022.2011.582111
PG 19
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 774YU
UT WOS:000291423500006
ER
PT J
AU Morris, BA
Shakespeare-Finch, J
AF Morris, Bronwyn A.
Shakespeare-Finch, Jane
TI Cancer Diagnostic Group Differences in Posttraumatic Growth: Accounting
for Age, Gender, Trauma Severity, and Distress
SO JOURNAL OF LOSS & TRAUMA
LA English
DT Article
ID BREAST-CANCER; SURVIVORS; STRESS; PREVALENCE; INVENTORY
AB The type of cancer diagnosed can have a differential impact on postdiagnosis adjustment (e. g., coping strategies, likelihood to complete treatment). Investigations examining cancer diagnostic differences in posttraumatic growth (PTG) are yet to be published. The current study examined 235 participants who had been treated at a regional hospital for all forms of cancer. Group differences in PTG were assessed through a cross-sectional design between breast, prostate, hematological, and colorectal cancer survivors. Results demonstrated that breast cancer survivors reported significantly higher levels of PTG than those diagnosed with colorectal and hematological malignancies, but not significantly different from prostate cancer survivors. While cancer diagnostic group differences in PTG were evident, PTG levels were also positively associated with trauma severity and distress. These results are discussed in terms of developing a postdiagnosis care model that can be utilized across all cancer type diagnoses in order to assist adaptation during this challenging time.
C1 [Shakespeare-Finch, Jane] Queensland Univ Technol, Sch Psychol & Counselling, Kelvin Grove, Qld 4059, Australia.
[Morris, Bronwyn A.] NHGRI, NIH, Bethesda, MD 20892 USA.
RP Shakespeare-Finch, J (reprint author), Queensland Univ Technol, Sch Psychol & Counselling, Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia.
EM j.shakespeare-finch@qut.edu.au
OI Shakespeare-Finch, Jane/0000-0003-4237-1320
NR 26
TC 8
Z9 8
U1 2
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1532-5024
J9 J LOSS TRAUMA
JI J. Loss Trauma
PY 2011
VL 16
IS 3
BP 229
EP 242
DI 10.1080/15325024.2010.519292
PG 14
WC Psychology, Social
SC Psychology
GA 766LQ
UT WOS:000290784200003
ER
PT J
AU Airavaara, M
Harvey, BK
Voutilainen, MH
Chou, J
Lindholm, P
Lindahl, M
Tuominen, RK
Saarma, M
Wang, Y
Hoffer, B
AF Airavaara, M.
Harvey, B. K.
Voutilainen, M. H.
Chou, J.
Lindholm, P.
Lindahl, M.
Tuominen, R. K.
Saarma, M.
Wang, Y.
Hoffer, B.
TI CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery
After MPTP Treatment n Mice
SO CELL TRANSPLANTATION
LA English
DT Meeting Abstract
CT 11th International Neural Transplantation and Repair Meeting/18th Annual
Meeting of the American-Society-for-Neural-Therapy-and-Repair
CY MAY 04-08, 2011
CL Clearwater, FL
SP Amer Soc Neural Therapy & Repair
C1 [Airavaara, M.; Harvey, B. K.; Chou, J.; Wang, Y.; Hoffer, B.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA.
[Voutilainen, M. H.; Tuominen, R. K.] Univ Helsinki, Dept Pharmacol & Toxicol, Fac Pharm, FIN-00170 Helsinki, Finland.
[Lindholm, P.; Lindahl, M.; Saarma, M.] Univ Helsinki, Inst Biotechnol, Helsinki, Finland.
OI Airavaara, Mikko/0000-0002-2026-1609
NR 0
TC 0
Z9 0
U1 0
U2 2
PU COGNIZANT COMMUNICATION CORP
PI ELMSFORD
PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA
SN 0963-6897
J9 CELL TRANSPLANT
JI Cell Transplant.
PY 2011
VL 20
IS 4
BP 544
EP 545
PG 2
WC Cell & Tissue Engineering; Medicine, Research & Experimental;
Transplantation
SC Cell Biology; Research & Experimental Medicine; Transplantation
GA 758VZ
UT WOS:000290196600012
ER
PT J
AU Airavaara, M
Harvey, BK
Hinzman, J
Simons, EM
Chiocco, MJ
Howard, DB
Shen, H
Gerhardt, G
Hoffer, BJ
Wang, Y
AF Airavaara, M.
Harvey, B. K.
Hinzman, J.
Simons, E. M.
Chiocco, M. J.
Howard, D. B.
Shen, H.
Gerhardt, G.
Hoffer, B. J.
Wang, Y.
TI Intracortical Delivery of an Adeno-Associated Viral Vector Expressing
the Glutamate Transporter (GLT-1) Decreases Stroke-Induced Extracellular
Glutamate Overflow and Cerebral Infarction After Transient Middle
Cerebral Artery Occlusion in Rats
SO CELL TRANSPLANTATION
LA English
DT Meeting Abstract
CT 11th International Neural Transplantation and Repair Meeting/18th Annual
Meeting of the American-Society-for-Neural-Therapy-and-Repair
CY MAY 04-08, 2011
CL Clearwater, FL
SP Amer Soc Neural Therapy & Repair
C1 [Airavaara, M.; Harvey, B. K.; Simons, E. M.; Chiocco, M. J.; Howard, D. B.; Shen, H.; Hoffer, B. J.; Wang, Y.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA.
[Hinzman, J.; Gerhardt, G.] Univ Kentucky, Dept Anat & Neurobiol, Coll Med, Ctr Microelectrode Technol, Lexington, KY 40536 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU COGNIZANT COMMUNICATION CORP
PI ELMSFORD
PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA
SN 0963-6897
J9 CELL TRANSPLANT
JI Cell Transplant.
PY 2011
VL 20
IS 4
BP 544
EP 544
PG 1
WC Cell & Tissue Engineering; Medicine, Research & Experimental;
Transplantation
SC Cell Biology; Research & Experimental Medicine; Transplantation
GA 758VZ
UT WOS:000290196600011
ER
PT J
AU Subramanian, T
Venkiteswaran, K
Rowlands, A
Ramachandra, R
Lieu, C
Rao, A
Chen, J
Freed, W
AF Subramanian, T.
Venkiteswaran, K.
Rowlands, A.
Ramachandra, R.
Lieu, C.
Rao, A.
Chen, J.
Freed, W.
TI Human Retinal Pigment Epithelial Cell (HRPEC) Cografts Improve Survival
of Xenografted Dopaminergic Human Embryonic Stem Cells (hES), Diminish
Host Inflammation, and Immune Response
SO CELL TRANSPLANTATION
LA English
DT Meeting Abstract
CT 11th International Neural Transplantation and Repair Meeting/18th Annual
Meeting of the American-Society-for-Neural-Therapy-and-Repair
CY MAY 04-08, 2011
CL Clearwater, FL
SP Amer Soc Neural Therapy & Repair
C1 [Subramanian, T.; Venkiteswaran, K.; Rowlands, A.; Ramachandra, R.; Lieu, C.; Rao, A.] Penn State Coll Med, Hershey, PA USA.
[Chen, J.; Freed, W.] NIDA, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU COGNIZANT COMMUNICATION CORP
PI ELMSFORD
PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA
SN 0963-6897
J9 CELL TRANSPLANT
JI Cell Transplant.
PY 2011
VL 20
IS 4
BP 587
EP 588
PG 2
WC Cell & Tissue Engineering; Medicine, Research & Experimental;
Transplantation
SC Cell Biology; Research & Experimental Medicine; Transplantation
GA 758VZ
UT WOS:000290196600132
ER
PT J
AU Zhang, Y
Huh, HKH
Shan, L
Malik, N
Diaz-Ruiz, O
Hoffer, BJ
Granholm, AC
Backman, CM
AF Zhang, Y.
Huh, H. K-H
Shan, L.
Malik, N.
Diaz-Ruiz, O.
Hoffer, B. J.
Granholm, A-C
Baeckman, C. M.
TI Embryonic Dopamine Neurons Genetically Modified to Enhance Akt/PKB
Activation Provide Functional Improvements When Transplanted Into the
Striata of the MitoPark Mouse Model
SO CELL TRANSPLANTATION
LA English
DT Meeting Abstract
CT 11th International Neural Transplantation and Repair Meeting/18th Annual
Meeting of the American-Society-for-Neural-Therapy-and-Repair
CY MAY 04-08, 2011
CL Clearwater, FL
SP Amer Soc Neural Therapy & Repair
C1 [Zhang, Y.; Huh, H. K-H; Shan, L.; Malik, N.; Diaz-Ruiz, O.; Hoffer, B. J.; Baeckman, C. M.] NIDA, NIH, Cellular Neurobiol Branch, Baltimore, MD USA.
[Granholm, A-C] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU COGNIZANT COMMUNICATION CORP
PI ELMSFORD
PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA
SN 0963-6897
J9 CELL TRANSPLANT
JI Cell Transplant.
PY 2011
VL 20
IS 4
BP 591
EP 591
PG 1
WC Cell & Tissue Engineering; Medicine, Research & Experimental;
Transplantation
SC Cell Biology; Research & Experimental Medicine; Transplantation
GA 758VZ
UT WOS:000290196600143
ER
PT S
AU Chow, CC
Ong, KM
Dougherty, EJ
Simons, SS
AF Chow, Carson C.
Ong, Karen M.
Dougherty, Edward J.
Simons, S. Stoney, Jr.
BE Johnson, ML
Brand, L
TI INFERRING MECHANISMS FROM DOSE-RESPONSE CURVES
SO METHODS IN ENZYMOLOGY, VOL 487: COMPUTER METHODS, PT C
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID GLUCOCORTICOID-RECEPTOR TRANSACTIVATION; INDUCTION PROPERTIES; SECONDARY
MEDIATORS; HORMONE-BINDING; GENE INDUCTION; TRANSCRIPTION; SYSTEMS;
REPRESSION; MODULATION; DOMAIN
AB The steady state dose response curve of ligand-mediated gene induction usually appears to precisely follow a first-order Hill equation (Hill coefficient equal to 1). Additionally, various cofactors/reagents can affect both the potency and the maximum activity of gene induction in a gene-specific manner. Recently, we have developed a general theory for which an unspecified sequence of steps or reactions yields a first-order Hill dose response curve (FHDC) for plots of the final product versus initial agonist concentration. The theory requires only that individual reactions "dissociate" from the downstream reactions leading to the final product, which implies that intermediate complexes are weakly bound or exist only transiently. We show how the theory can be utilized to make predictions of previously unidentified mechanisms and the site of action of cofactors/reagents. The theory is general and can be applied to any biochemical reaction that has a FHDC.
C1 [Chow, Carson C.; Ong, Karen M.] NIDDK, Lab Biol Modeling, CEB, NIH, Bethesda, MD 20892 USA.
[Dougherty, Edward J.; Simons, S. Stoney, Jr.] NIDDK, Steroid Hormones Sect, CEB, NIH, Bethesda, MD USA.
RP Chow, CC (reprint author), NIDDK, Lab Biol Modeling, CEB, NIH, Bethesda, MD 20892 USA.
RI Chow, Carson/A-7970-2009;
OI Dougherty, Edward/0000-0001-7664-9779
NR 22
TC 12
Z9 12
U1 0
U2 5
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-381270-4
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2011
BP 465
EP 483
DI 10.1016/S0076-6879(11)87016-3
PG 19
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BTC96
UT WOS:000286532000016
ER
PT S
AU Samuels, Y
Waldman, T
AF Samuels, Yardena
Waldman, Todd
BE Rommel, C
Vanhaesebroeck, B
Vogt, PK
TI Oncogenic Mutations of PIK3CA in Human Cancers
SO PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE, VOL 2
SE Current Topics in Microbiology and Immunology
LA English
DT Review; Book Chapter
ID SQUAMOUS-CELL CARCINOMA; MIDDLE-EASTERN POPULATION; ANAPLASTIC
THYROID-CANCER; BREAST-CANCER; COLORECTAL CANCERS; GENE-MUTATIONS;
HIGH-FREQUENCY; LUNG-CANCER; ENDOMETRIAL CARCINOMA; COLON-CANCER
AB The involvement of the PIK3CA gene product p110 alpha, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support for this proposal had been provided by both genetic and functional studies, including most recently the discovery of common activating missense mutations of PIK3CA in a wide variety of common human tumor types. This chapter will focus on the discovery of these mutations and describes their relevance to a wide range of common human tumor types.
Of note, the identification and functional analysis of the PIK3CA gene are reviewed in other chapters in this book. However, a brief mention will be made here of its general properties as background to our focus on the discovery of its cancer-specific mutations.
C1 [Samuels, Yardena] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
[Waldman, Todd] Georgetown Univ, Sch Med, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC USA.
RP Samuels, Y (reprint author), NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA.
EM samuelsy@mail.nih.gov
FU Intramural NIH HHS [Z01 HG200337-01]; NCI NIH HHS [R01 CA115699, R01
CA115699-05, R01 CA115699-04]
NR 140
TC 11
Z9 12
U1 1
U2 10
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0070-217X
BN 978-3-642-14816-3
J9 CURR TOP MICROBIOL
JI Curr.Top.Microbiol.Immunol.
PY 2011
VL 347
BP 21
EP 41
DI 10.1007/82_2010_68
D2 10.1007/978-3-642-14816-3
PG 21
WC Oncology; Immunology; Medicine, Research & Experimental; Microbiology
SC Oncology; Immunology; Research & Experimental Medicine; Microbiology
GA BSJ47
UT WOS:000284609400002
PM 20535651
ER
PT J
AU Li, G
Xie, HC
Ning, H
Citrin, D
Kaushal, A
Camphausen, K
Miller, RW
AF Li, Guang
Xie, Huchen
Ning, Holly
Citrin, Deborah
Kaushal, Aradhana
Camphausen, Kevin
Miller, Robert W.
TI Correction of motion-induced misalignment in co-registered PET/CT and
MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery
SO JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
LA English
DT Article
DE 3D volumetric image registration; co-registered PET/CT and MRI/MRI
images; head motion; target delineation and localization; high-precision
stereotactic radiosurgery (SRS)
ID POSITRON-EMISSION-TOMOGRAPHY; ACCURACY; CT; SYSTEM; REGISTRATION;
RADIOTHERAPY; ONCOLOGY; SCANNER; VOLUME; BRAIN
AB The purpose was to evaluate and correct the co-registration of diagnostic PET/CT and MRI/MRI images for stereotactic radiosurgery (SRS) using 3D volumetric image registration (3DVIR). The 3DVIR utilizes the homogeneity of color distribution over a volumetric anatomical landmark as the registration criterion with submillimeter accuracy. Fifty-three PET/CT and MRI (T1, T2 and FLAIR) image sets of patients with brain lesions were acquired sequentially from a hybrid PET/CT or an MRI scanner with common diagnostic head holding devices. Twenty-five sets of head (18)F-FDG-PET/CT images were scanned over a 10-minute interval and 14 whole-body sets were scanned over a 30-minute interval. Fourteen sets of MRI images were acquired, and each 3-modal image set (T1, T2 and FLAIR) was scanned in sequence at time 0, similar to 5 and similar to 20 minutes. The misalignments in these "co-registered" images were evaluated and corrected using the 3DVIR. Using the head immobilization devices commonly found in diagnostic PET/CT and MRI/MRI imaging, 80%-100% of these "co-registered" images were identified as misaligned. For PET/CT, the magnitude of misalignment was 0.4 degrees +/- 0.5 degrees and 0.7 +/- 0.4 mm for 10-minute scans, and 0.8 degrees +/- 1.2 degrees and 2.7 +/- 1.7 mm for 30-minute scans. For MRI/MRI, the magnitude was 0.2 degrees +/- 0.4 degrees and 0.3 +/- 0.2 mm for 5-minute scan intervals, and 1.1 degrees +/- 0.7 degrees and 1.2 +/- 1.4 mm for 20-minute intervals. Small, but significant, misalignment is present in the co-registered diagnostic PET/CT and MRI/MRI images and can be corrected in SRS treatment planning using the volumetric image registration for improved target localization within the clinical error tolerance.
C1 [Li, Guang; Xie, Huchen; Ning, Holly; Citrin, Deborah; Kaushal, Aradhana; Camphausen, Kevin; Miller, Robert W.] NCI, Radiat Oncol Branch, Clin Res Ctr, NIH, Bethesda, MD 20892 USA.
RP Li, G (reprint author), Mem Sloan Kettering Canc Ctr, Dept Med Phys, Box 84,Room 112C,1275 York Ave, New York, NY 10065 USA.
EM lig2@mskcc.org
OI Li, Guang/0000-0002-9022-2883
NR 26
TC 1
Z9 1
U1 1
U2 2
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 1526-9914
J9 J APPL CLIN MED PHYS
JI J. Appl. Clin. Med. Phys
PY 2011
VL 12
IS 1
BP 58
EP 67
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 750MO
UT WOS:000289551600007
ER
PT J
AU Hiranita, T
Tanda, G
Kopajtic, T
Katz, J
AF Hiranita, Takato
Tanda, Gianluigi
Kopajtic, Theresa
Katz, Jonathan
TI Cocaine (Coc) self administration (SA) induces the reinforcing effects
of the selective sigma 1-receptor (sigma 1R) agonists
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Meeting Abstract
CT 84th Annual Meeting of the Japanese-Pharmacological-Society/11th
Southeast Asian Western Pacific Regional Meeting of Pharmacologists
CY MAR 22-24, 2011
CL Yokohama, JAPAN
SP Japanese Pharmacolog Soc
C1 [Hiranita, Takato; Tanda, Gianluigi; Kopajtic, Theresa; Katz, Jonathan] NIDA, Medicat Discovery Res Branch, IRP, NIH,DHHS,Biomed Res Ctr, Baltimore, MD 21224 USA.
RI Hiranita, Takato/G-6567-2011; Tanda, Gianluigi/B-3318-2009
OI Tanda, Gianluigi/0000-0001-9526-9878
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PY 2011
VL 115
SU 1
BP 147P
EP 147P
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 743QU
UT WOS:000289034600501
ER
PT J
AU Unno, T
Inasaki, M
Matsuyama, H
Tanahashi, Y
Kitazawa, T
Yamada, M
Wess, Y
Komori, S
AF Unno, Toshihiro
Inasaki, Michiko
Matsuyama, Hayato
Tanahashi, Yasuyuki
Kitazawa, Takio
Yamada, Masahisa
Wess, Yurgen
Komori, Seiichi
TI Role of M3 muscarinic receptor-coupled signalling molecule in the
activation of muscarinic cation channels in mouse ileal smooth muscle
cells
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Meeting Abstract
CT 84th Annual Meeting of the Japanese-Pharmacological-Society/11th
Southeast Asian Western Pacific Regional Meeting of Pharmacologists
CY MAR 22-24, 2011
CL Yokohama, JAPAN
SP Japanese Pharmacolog Soc
C1 [Unno, Toshihiro; Inasaki, Michiko; Matsuyama, Hayato; Komori, Seiichi] Gifu Univ, Dept Vet Med, Pharmacol Lab, Gifu 5011193, Japan.
[Tanahashi, Yasuyuki] Kyoto Sangyo Univ, Dept Anim Med Sci, Kita Ku, Kyoto 6038555, Japan.
[Kitazawa, Takio] Rakuno Gakuen Univ, Dept Pharmacol, Ebetsu, Hokkaido 0698501, Japan.
[Yamada, Masahisa] Okinawa Inst Sci Tech, Common Resources Grp, Onna Son, Okonawa 9040412, Japan.
[Wess, Yurgen] NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PY 2011
VL 115
SU 1
BP 217P
EP 217P
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 743QU
UT WOS:000289034601251
ER
PT J
AU Nemeth, A
Stadler, K
Jakus, J
Vidoczy, T
AF Nemeth, A.
Stadler, K.
Jakus, J.
Vidoczy, T.
TI KINETICS OF PEROXYNITRITE FORMATION AND DECAY IN DIABETIC RAT AORTA
SO OXIDATION COMMUNICATIONS
LA English
DT Article
DE superoxide; nitric oxide; superoxide dismutase (SOD); tyrosine; reaction
mechanism
ID NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; TYROSINE NITRATION;
BIOLOGICAL-SYSTEMS; RADICAL FORMATION; (NO)-N-CENTER-DOT; DECOMPOSITION;
CONSUMPTION; CELLS; ONOO
AB Detailed reaction mechanism compiled from literature was tested on diabetic rat aorta samples for which nitric oxide, superoxide formations and spin clearance rate were measured by electron paramagnetic resonance (EPR) method. The rate of superoxide formation was 1.0x10(-7) M s(-1). Kinetic calculations predicted ranges of nitric oxide formation rate and of nitric oxide, superoxide, peroxynitrite concentrations viable in the investigated biological entity.
C1 [Nemeth, A.; Jakus, J.] Hungarian Acad Sci, Inst Biomol Chem, Chem Res Ctr, H-1025 Budapest, Hungary.
[Stadler, K.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Vidoczy, T.] Hungarian Acad Sci, Inst Struct Chem, Chem Res Ctr, H-1025 Budapest, Hungary.
RP Nemeth, A (reprint author), Hungarian Acad Sci, Inst Biomol Chem, Chem Res Ctr, 59-67 Pusztaszeri St, H-1025 Budapest, Hungary.
EM anemeth@chemres.hu
RI Vidoczy, Tamas/H-6177-2012
NR 30
TC 2
Z9 2
U1 0
U2 1
PU SCIBULCOM LTD
PI SOFIA
PA PO BOX 249, 1113 SOFIA, BULGARIA
SN 0209-4541
J9 OXID COMMUN
JI Oxid. Commun.
PY 2011
VL 34
IS 1
BP 128
EP 135
PG 8
WC Chemistry, Multidisciplinary
SC Chemistry
GA 749FF
UT WOS:000289448500018
ER
PT J
AU Munster, V
Feldmann, H
AF Munster, Vincent
Feldmann, Heinz
TI Ecology of Emerging Viruses: Bridging the Gap Between Field and
Experimental Research
SO ECOHEALTH
LA English
DT Meeting Abstract
C1 [Munster, Vincent; Feldmann, Heinz] NIAID, Virol Lab, Rocky Mt Labs, Div Intramural Res,NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1612-9202
J9 ECOHEALTH
JI EcoHealth
PY 2011
VL 7
SU 1
BP S68
EP S68
PG 1
WC Biodiversity Conservation; Ecology; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 728VB
UT WOS:000287901500114
ER
PT J
AU Huebner, RB
Kantor, LW
AF Huebner, Robert B.
Kantor, Lori Wolfgang
TI Advances in Alcoholism Treatment
SO ALCOHOL RESEARCH & HEALTH
LA English
DT Article
DE Alcohol use disorders; alcohol dependence; alcoholism; treatment;
treatment models; treatment research; treatment issues;
cost-effectiveness; pharmacotherapy; medication therapy; behavior
therapy; emerging technologies; co-treatment; 12-step-model; continuing
care; health care delivery
ID UNITED-STATES; DEPENDENCE; RECOVERY
AB Researchers are working on numerous and varied approaches to improving the accessibility, quality, effectiveness, and cost-effectiveness of treatment for alcohol use disorders (AUDs). This overview article summarizes the approaches reviewed in this issue, including potential future developments for alcoholism treatment, such as medications development, behavioral therapy, advances in technology that are being used to improve treatment, integrated care of patients with AUDs and co-occurring disorders, the role of 12-step programs in the broader realm of treatment, treating patients with recurring and chronic alcohol dependence, strategies to close the gap between treatment need and treatment utilization, and how changes in the health care system may affect the delivery of treatment. This research will not only reveal new medications and behavioral therapies but also will contribute to new ways of approaching current treatment problems.
C1 [Huebner, Robert B.] NIAAA, Div Treatment & Recovery Res, Rockville, MD 20852 USA.
[Kantor, Lori Wolfgang] Alcohol Res & Hlth, Springfield, VA USA.
RP Huebner, RB (reprint author), NIAAA, Div Treatment & Recovery Res, Rockville, MD 20852 USA.
NR 7
TC 7
Z9 7
U1 2
U2 7
PU NATL INST ALCOHOL ABUSE ALCOHOLISM
PI ROCKVILLE
PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA
SN 1535-7414
J9 ALCOHOL RES HEALTH
JI Alcohol Res. Health
PY 2011
VL 33
IS 4
BP 295
EP 299
PG 5
WC Substance Abuse
SC Substance Abuse
GA 731KO
UT WOS:000288105600001
PM 23580014
ER
PT J
AU Xie, HC
Liang, Y
Lao, DQ
Zhang, TY
Ito, Y
AF Xie Huichun
Liang, Yong
Lao, Deqiang
Zhang, Tianyou
Ito, Yoichiro
TI PREPARATIVE SEPARATION OF HIGH-PURITY CORDYCEPIN FROM CORDYCEPS
MILITARIS(L.) LINK BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE Cordyceps militaris(L; ) link; cordycepin; countercurrent
chromatography; preparative chromatography
ID PURIFICATION
AB A high-speed counter-current chromatography (HSCCC) technique in a preparative scale has been applied to separate and purify cordycepin from the extract of Cordyceps militaris(L.) Link by a one-step separation. A high efficiency of HSCCC separation was achieved on a two-phase solvent system of n-hexane-n-butanol-methanol-water (23:80:30:155, v/v/v/v) by eluting the lower mobile phase at a flow rate of 2mL/min under a revolution speed of 850rpm. HSCCC separation of 216.2mg crude sample (contained cordycepin at 44.7% purity after 732 cation-exchange resin clean-up) yielded 64.8mg cordycepin with purity of 98.9% and 91.7% recovery. Identification of the target compound was performed by UV, IR, MS, 1H NMR, and 13C NMR.
C1 [Xie Huichun; Liang, Yong; Lao, Deqiang] S China Normal Univ, Sch Chem & Environm, Guangzhou 510631, Guangdong, Peoples R China.
[Zhang, Tianyou] Beijing Inst New Technol Applicat, Beijing, Peoples R China.
[Ito, Yoichiro] NHLBI, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
RP Liang, Y (reprint author), S China Normal Univ, Sch Chem & Environm, Guangzhou 510631, Guangdong, Peoples R China.
EM liangy@scnu.edu.cn; itoy2@mail.nih.gov
NR 14
TC 0
Z9 0
U1 1
U2 19
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1082-6076
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PY 2011
VL 34
IS 7
BP 491
EP 499
AR PII 935387120
DI 10.1080/10826076.2011.556965
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 742QH
UT WOS:000288959000001
ER
PT J
AU Friedman, A
Danis, M
AF Friedman, Alex
Danis, Marion
TI INTRANSITIVITY AND PRIORITY SETTING
SO JOURNAL OF PHILOSOPHICAL RESEARCH
LA English
DT Article
AB It is a basic and intuitive assumption that the relation of moral preference must be transitive-if A is overall morally preferable to B; and B is overall morally preferably to C; then, if our views are coherent, it better be the case that A is overall morally preferable to C. However, recent work by Temkin and Rachels has undermined that assumption by showing that common-sense ethical distributive principles that we are unlikely to give up generate intransitive sets of moral preferences. The consequences of this for resource allocation are profound-how can we come up with a just way of rationing limited resources if whatever course of action we adopt, there will be other alternatives that are morally preferable to it? However, regardless of the theoretical challenges, practical resource allocation decisions must be made every day! We explore an approach to dealing with some of the pragmatic aspects of the problem, even though the theoretical problem of intransitivity remains unsolved. We begin by considering whether the ways in which counterexamples to transitivity have (of necessity) been oversimplified actually contribute to the intractability of the problem by taking the possibilities of cost sharing, benefit splitting, and compensation (which are often available in real-life tradeoff situations) off the table. The proposal we end up suggesting does not rely on any assumptions or judgments about interpersonal aggregation, and so has a chance of allowing us to work around the most troubling kind of intransitivity.
C1 [Friedman, Alex; Danis, Marion] NIH, Ctr Clin, Bethesda, MD 20892 USA.
RP Friedman, A (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA.
NR 15
TC 1
Z9 1
U1 0
U2 1
PU PHILOSOPHY DOCUMENTATION CENTER
PI CHARLOTTESVILLE
PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA
SN 1053-8364
J9 J PHILOS RES
JI J. Philos. Res.
PY 2011
VL 36
BP 173
EP 189
PG 17
WC Philosophy
SC Philosophy
GA 738GE
UT WOS:000288627500010
ER
PT J
AU Conde-Agudelo, A
Belizan, JM
Diaz-Rossello, J
AF Conde-Agudelo, A.
Belizan, J. M.
Diaz-Rossello, J.
TI Kangaroo mother care to reduce morbidity and mortality in low
birthweight infants
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Infant Mortality; Infant, Low Birth Weight; Infant Care [methods];
Infant, Newborn; Length of Stay; Physical Stimulation [methods];
Randomized Controlled Trials as Topic; Weight Gain; Humans
ID SKIN-TO-SKIN; RANDOMIZED CONTROLLED-TRIAL; CONVENTIONAL INCUBATOR CARE;
PRETERM INFANTS; TRADITIONAL CARE; NEONATAL DEATHS; UTTAR-PRADESH;
CONTACT; GROWTH; ATTACHMENT
AB Background
Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants.
Objectives
To determine whether there is evidence to support the use of KMC in LBW infants as an alternative to conventional neonatal care.
Search strategy
The standard search strategy of the Cochrane Neonatal Group was used. This included searches of MEDLINE, EMBASE, LILACS, POPLINE, CINAHL databases (from inception to January 31, 2011), and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2011). In addition, we searched the web page of the Kangaroo Foundation, conference and symposia proceedings on KMC, and Google scholar. Selection criteria Randomized controlled trials comparing KMC versus conventional neonatal care, or early onset KMC (starting within 24 hours after birth) versus late onset KMC (starting after 24 hours after birth) in LBW infants.
Data collection and analysis
Data collection and analysis were performed according to the methods of the Cochrane Neonatal Review Group.
Main results
Sixteen studies, including 2518 infants, fulfilled inclusion criteria. Fourteen studies evaluated KMC in LBWinfants after stabilization, one evaluated KMC in LBW infants before stabilization, and one compared early onset KMC with late onset KMC in relatively stable LBW infants. Eleven studies evaluated intermittent KMC and five evaluated continuous KMC. At discharge or 40 -41 weeks' postmenstrual age, KMC was associated with a reduction in the risk of mortality (typical risk ratio (RR) 0.60, 95% confidence interval (CI) 0.39 to 0.93; seven trials, 1614 infants), nosocomial infection/sepsis (typical RR 0.42, 95% CI 0.24 to 0.73), hypothermia (typical RR 0.23, 95% CI 0.10 to 0.55), and length of hospital stay (typical mean difference 2.4 days, 95% CI 0.7 to 4.1). At latest follow up, KMC was associated with a decreased risk of mortality (typical RR 0.68, 95% CI 0.48 to 0.96; nine trials, 1952 infants) and severe infection/sepsis (typical RR 0.57, 95% CI 0.40 to 0.80). Moreover, KMC was found to increase some measures of infant growth, breastfeeding, and mother-infant attachment.
Authors' conclusions
The evidence from this updated review supports the use of KMC in LBWinfants as an alternative to conventional neonatal care mainly in resource-limited settings. Further information is required concerning effectiveness and safety of early onset continuous KMC in unstabilized LBW infants, long term neurodevelopmental outcomes, and costs of care.
C1 [Conde-Agudelo, A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Detroit, MI USA.
[Belizan, J. M.] Inst Clin Effectiveness & Hlth Policy IECS, Dept Mother & Child Hlth Res, Buenos Aires, DF, Argentina.
[Diaz-Rossello, J.] Univ Hosp, Dept Neonatol, Montevideo, Uruguay.
RP Conde-Agudelo, A (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Detroit, MI USA.
EM condeagu@hotmail.com
FU Perinatology Research Branch, Eunice Kennedy Shriver National Institute
of Child Health and Human Development/National Institutes of
Health/Department of Health and Human Services, Bethesda, MD and
Detroit, MI, USA; Department of Neonatology, University Hospital,
Montevideo, Uruguay; Department of Mother and Child Health Research,
Institute for Clinical Effectiveness and Health Policy (IECS), Buenos
Aires, Argentina
FX (AC-A) Perinatology Research Branch, Eunice Kennedy Shriver National
Institute of Child Health and Human Development/National Institutes of
Health/Department of Health and Human Services, Bethesda, MD and
Detroit, MI, USA.; (JLD-R) Department of Neonatology, University
Hospital, Montevideo, Uruguay.; (JMB) Department of Mother and Child
Health Research, Institute for Clinical Effectiveness and Health Policy
(IECS), Buenos Aires, Argentina.
NR 75
TC 48
Z9 48
U1 5
U2 27
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2011
IS 3
AR CD002771
DI 10.1002/14651858.CD002771.pub2
PG 117
WC Medicine, General & Internal
SC General & Internal Medicine
GA 735ZB
UT WOS:000288458200016
ER
PT J
AU Bard, KA
Brent, L
Lester, B
Worobey, J
Suomi, SJ
AF Bard, Kim A.
Brent, Linda
Lester, Barry
Worobey, John
Suomi, Stephen J.
TI Neurobehavioural Integrity of Chimpanzee Newborns: Comparisons Across
Groups and Across Species Reveal Gene-Environment Interaction Effects
SO INFANT AND CHILD DEVELOPMENT
LA English
DT Article
DE ape; infant; epigenesis; social cognition; early development; NBAS;
Brazelton test; emotion
ID EFE PYGMY INFANTS; PAN-TROGLODYTES; YOUNG CHIMPANZEES;
COGNITIVE-DEVELOPMENT; NEONATAL IMITATION; SOCIAL COGNITION; LATERAL
BIAS; ORIENTATION; EPIGENESIS; GESTURES
AB The aims of this article are to describe the neurobehavioural integrity of chimpanzee newborns, to investigate how early experiences affect the neurobehavioural organization of chimpanzees, and to explore species differences by comparing chimpanzee newborns with a group of typically developing human newborns. Neurobehavioural integrity related to orientation, motor performance, arousal, and state regulation of 55 chimpanzee (raised in four different settings) and 42 human newborns was measured with the Neonatal Behavioral Assessment Scale (NBAS), a semi-structured 25-min interactive assessment. Thirty-eight chimpanzees were tested every other day from birth, and the analyses revealed significant developmental changes in 19 of 27 NBAS scores. The cross-group and cross-species comparisons were conducted at 2 and 30 days of age. Among the four chimpanzee groups, significant differences were found in 23 of 24 NBAS scores. Surprisingly, the cross-species comparisons revealed that the human group was distinct in only 1 of the 25 NBAS scores (the human group had significantly less muscle tone than all the chimpanzee groups). The human group was indistinguishable from at least one of the chimpanzee groups in the remaining 24 of the 25 NBAS scores. The results of this study support the conclusion that the interplay between genes and environment, rather than genes alone or environment alone, accounts for phenotypic expressions of newborn neurobehavioural integrity in hominids. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Bard, Kim A.] Univ Portsmouth, Ctr Study Emot, Dept Psychol, Portsmouth PO1 2DY, Hants, England.
[Brent, Linda] ChimpHaven, Keithville, LA USA.
[Lester, Barry] Brown Univ, Warren Alpert Med Sch, Women & Infants Hosp, Providence, RI USA.
[Worobey, John] Rutgers State Univ, Dept Nutr Sci, Piscataway, NJ 08855 USA.
[Suomi, Stephen J.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, DHHS, Bethesda, MD USA.
RP Bard, KA (reprint author), Univ Portsmouth, Ctr Study Emot, Dept Psychol, King Henry Bldg, Portsmouth PO1 2DY, Hants, England.
EM kim.bard@port.ac.uk
FU NCRR NIH HHS [U42 RR003591, R24 RR006158, P51 RR000165]; NICHD NIH HHS
[F32 HD007105, R01 HD021013, T32 HD007105]
NR 100
TC 6
Z9 6
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1522-7227
J9 INFANT CHILD DEV
JI Infant Child Dev.
PD JAN-FEB
PY 2011
VL 20
IS 1
SI SI
BP 47
EP 93
DI 10.1002/icd.686
PG 47
WC Psychology, Developmental
SC Psychology
GA 721TN
UT WOS:000287378200005
PM 25110465
ER
PT J
AU Ozarslan, E
Shemesh, N
Koay, CG
Cohen, Y
Basser, PJ
AF Oezarslan, Evren
Shemesh, Noam
Koay, Cheng Guan
Cohen, Yoram
Basser, Peter J.
TI Nuclear magnetic resonance characterization of general compartment size
distributions
SO NEW JOURNAL OF PHYSICS
LA English
DT Article
ID SELF-DIFFUSION COEFFICIENT; RESTRICTED DIFFUSION; FIELD-GRADIENT;
EMULSION SYSTEMS; SPIN ECHOES; PFG-NMR; WATER; TIME; PROPAGATOR; MRI
AB The influence of molecular diffusion on the nuclear magnetic resonance (NMR) signal can be exploited to estimate compartment size distributions in heterogeneous specimens. Theoretical relationships between the NMR signal intensity at long diffusion times and the moments of a general distribution of isolated pores with characteristic shapes (planar, cylindrical or spherical) are established. A numerical method based on expressing a general diffusion-attenuated NMR signal profile in a series of complete orthogonal basis functions is introduced and subsequently used to estimate the moments of the compartment size distribution. The results on simulated and real data obtained from controlled water-filled microcapillaries demonstrate the power of the approach to create contrast based not only on the mean of the compartment size but also on its variance. The technique can be used to address a variety of problems such as characterizing distributions of droplet sizes in emulsions and of apparent axon diameters in nerve fascicles.
C1 [Oezarslan, Evren; Koay, Cheng Guan; Basser, Peter J.] NICHD, Sect Tissue Biophys & Biomimet, NIH, Bethesda, MD 20892 USA.
[Shemesh, Noam; Cohen, Yoram] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, IL-69978 Ramat Aviv, Israel.
RP Ozarslan, E (reprint author), NICHD, Sect Tissue Biophys & Biomimet, NIH, 13 South Dr, Bethesda, MD 20892 USA.
EM evren@helix.nih.gov
RI Ozarslan, Evren/B-4858-2013; Basser, Peter/H-5477-2011;
OI Ozarslan, Evren/0000-0003-0859-1311; Shemesh, Noam/0000-0001-6681-5876
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development
FX This work was supported by the Intramural Research Program of Eunice
Kennedy Shriver National Institute of Child Health and Human
Development.
NR 38
TC 9
Z9 9
U1 0
U2 12
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 1367-2630
J9 NEW J PHYS
JI New J. Phys.
PD JAN
PY 2011
VL 13
AR 015010
DI 10.1088/1367-2630/13/1/015010
PG 17
WC Physics, Multidisciplinary
SC Physics
GA 741YK
UT WOS:000288903600054
PM 21709780
ER
PT J
AU Yuan, M
Xu, JF
Yang, YN
Zheng, G
AF Yuan, Min
Xu, Jinfeng
Yang, Yaning
Zheng, Gang
TI A robust test for multi-ordered 2 x J ordinal contingency tables
SO STATISTICS AND ITS INTERFACE
LA English
DT Article
DE Efficiency robustness; Minimum p-values; Ordered categorical data;
Scoring; Trend tests; Two-locus model
ID CASE-CONTROL ASSOCIATION; GENOME-WIDE SCAN; CATEGORICAL-DATA; TREND
TESTS; MACULAR DEGENERATION; SAMPLE-SIZE; MODELS; DISEASE; SCORES;
POLYMORPHISM
AB Pearson's chi-square test and the Cochran-Armitage trend test are commonly used in the analysis of 2 x J contingency tables. When the J columns are nominal, Pearson's test should be considered. On the other hand, when the J columns are ordinal and the ordering is well defined, the trend test should be used. In practice, however, the columns are often ordered but the ordering may not be uniquely defined, especially the J categories may be ordered in multiple ways according to several different factors. We assume that the columns could be either singly or multi-ordered, either being scientifically plausible, and consequently different scores could be assigned to the columns by the different ordering systems. Then the trend test, if applied, may lose substantial power when the orderings are misspecified. To guard against misspecifications of the scores for the columns, we propose a robust test by combining strengths of both Pearson's test and the trend test. In the trend test, we allow several different score specifications according to different ordering criteria and the scores are chosen to be robust enough. Extensive simulation studies demonstrate the efficiency robustness of the proposed approach. The proposed method is applied to two data sets from the Genetic Association Workshop 15 and an experiment on the use of sulfones and streptomycin drugs in the treatment of leprosy.
C1 [Zheng, Gang] NHLBI, Off Biostat Res, DPPS, Bethesda, MD 20892 USA.
[Yang, Yaning] Univ Sci & Technol China, Dept Stat & Finance, Hefei 230026, Peoples R China.
[Xu, Jinfeng] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117546, Singapore.
[Yuan, Min] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China.
RP Zheng, G (reprint author), NHLBI, Off Biostat Res, DPPS, Bldg 10, Bethesda, MD 20892 USA.
EM myuan@fudan.edu.cn; st.axj@nus.edu.sg; ynyang@ustc.edu.cn;
zhengg@nhlbi.nih.gov
FU China NSF; NUS [R155-000-075-112]; GAW grant [R01 GM031575]
FX The work of Y. Yang is supported by China NSF Grant. The work of J. Xu
is supported by NUS grant R155-000-075-112. We would like to thank both
reviewers, and the editors for helpful comments and suggestions which
improved our presentation. The use of GAW data was approved by the GAW
grant, R01 GM031575.
NR 31
TC 0
Z9 0
U1 1
U2 4
PU INT PRESS BOSTON, INC
PI SOMERVILLE
PA PO BOX 43502, SOMERVILLE, MA 02143 USA
SN 1938-7989
J9 STAT INTERFACE
JI Stat. Interface
PY 2011
VL 4
IS 1
BP 1
EP 10
PG 10
WC Mathematical & Computational Biology; Mathematics, Interdisciplinary
Applications
SC Mathematical & Computational Biology; Mathematics
GA 738ZS
UT WOS:000288681800001
ER
PT J
AU Zhang, H
Ahn, JY
Yu, K
AF Zhang, Hong
Ahn, Jiyoung
Yu, Kai
TI Comparing statistical methods for removing seasonal variation from
vitamin D measurements in case-control studies
SO STATISTICS AND ITS INTERFACE
LA English
DT Article
DE 25-hydroxy vitamin D; Partial linear model; Locally weighted polynomial
regression; Penalized regression splines; Prostate cancer; Seasonal
pattern; Sine curve
ID LOCALLY WEIGHTED REGRESSION
AB Vitamin D deficiency has been shown to be associated with multiple clinical outcomes, including osteoporosis, multiple sclerosis and colorectal cancer. In studies of vitamin D effect on disease outcome, vitamin D status is usually measured by a serum biomarker, namely 25-hydroxy vitamin D [25(OH)D]. Since the circulating 25(OH)D concentration varies from season to season and not all blood samples are collected at the same time, the disease-vitamin D relationship can be obscured if the seasonal variation is not adjusted properly. In the literature, a two-step procedure is usually adopted, with the vitamin D level adjusted for the seasonal variation being obtained in the first step, and the effect of vitamin D being assessed based on the adjusted vitamin D level at the second step. This two-step method can generate misleading results as the estimation variance arising from the first step is not taken into account in the second step analysis. We consider three alternative procedures that unify the two steps into a single model. We conduct an extensive simulation study to evaluate the performance of these methods and demonstrate their applications in a study of 25(OH)D effect on prostate cancer risk.
C1 [Zhang, Hong; Yu, Kai] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Zhang, Hong] Fudan Univ, Inst Biostat, Shanghai, Peoples R China.
[Ahn, Jiyoung] NYU, Dept Environm Med, Sch Med, Div Epidemiol, New York, NY 10016 USA.
RP Yu, K (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
EM zhanghfd@fudan.edu.cn; jiyoung.ahn@nyumc.org; yuka@mail.nih.gov
FU NIH; National Cancer Institute
FX We thank B. J. Stone for her editorial help. This research utilized the
high-performance computational capabilities of the Biowulf PC/Linux
cluster at the National Institutes of Health, Bethesda, Maryland, USA
(http://biowulf.nih.gov). The work of K. Yu and H. Zhang was supported
in part by the Intramural Program of the NIH and the National Cancer
Institute.
NR 14
TC 1
Z9 1
U1 0
U2 5
PU INT PRESS BOSTON, INC
PI SOMERVILLE
PA PO BOX 43502, SOMERVILLE, MA 02143 USA
SN 1938-7989
J9 STAT INTERFACE
JI Stat. Interface
PY 2011
VL 4
IS 1
BP 85
EP 93
PG 9
WC Mathematical & Computational Biology; Mathematics, Interdisciplinary
Applications
SC Mathematical & Computational Biology; Mathematics
GA 738ZS
UT WOS:000288681800009
PM 24089626
ER
PT J
AU Yuan, A
Chen, GJ
Xiong, JA
He, WQ
Jin, W
Rotimi, C
AF Yuan, Ao
Chen, Guanjie
Xiong, Juan
He, Wenqing
Jin, Wen
Rotimi, Charles
TI Bayesian-frequentist hybrid model with application to the analysis of
gene copy number changes
SO JOURNAL OF APPLIED STATISTICS
LA English
DT Article
DE Bayesian; gene copy number; frequentist; hybrid model; prior information
ID COMPARATIVE GENOMIC HYBRIDIZATION; ARRAY-CGH DATA; MAXIMUM-LIKELIHOOD;
LUNG-CANCER; MICROARRAYS; ALGORITHM; REGRESSION; PROGRAM; TUMORS
AB Gene copy number (GCN) changes are common characteristics of many genetic diseases. Comparative genomic hybridization (CGH) is a new technology widely used today to screen the GCN changes in mutant cells with high resolution genome-wide. Statistical methods for analyzing such CGH data have been evolving. Existing methods are either frequentist's or full Bayesian. The former often has computational advantage, while the latter can incorporate prior information into the model, but could be misleading when one does not have sound prior information. In an attempt to take full advantages of both approaches, we develop a Bayesian-frequentist hybrid approach, in which a subset of the model parameters is inferred by the Bayesian method, while the rest parameters by the frequentist's. This new hybrid approach provides advantages over those of the Bayesian or frequentist's method used alone. This is especially the case when sound prior information is available on part of the parameters, and the sample size is relatively small. Spatial dependence and false discovery rate are also discussed, and the parameter estimation is efficient. As an illustration, we used the proposed hybrid approach to analyze a real CGH data.
C1 [Yuan, Ao] Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA.
[Chen, Guanjie; Rotimi, Charles] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA.
[Xiong, Juan; He, Wenqing] Univ Western Ontario, Dept Stat & Actuarial Sci, London, ON, Canada.
[Jin, Wen] Suizhou Cent Hosp, Suizhou 441300, Hubei, Peoples R China.
RP Yuan, A (reprint author), Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA.
EM yuanao@hotmail.com
FU National Center for Research Resources at NIH [2G12RR003048]; Center for
Research on Genomics and Global Health (CRGGH) at NHGRI/NIH
FX This work is supported in part by the National Center for Research
Resources at NIH grant 2G12RR003048, and by the Center for Research on
Genomics and Global Health (CRGGH) at NHGRI/NIH.
NR 35
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U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0266-4763
J9 J APPL STAT
JI J. Appl. Stat.
PY 2011
VL 38
IS 5
BP 987
EP 1005
DI 10.1080/02664761003692449
PG 19
WC Statistics & Probability
SC Mathematics
GA 734WX
UT WOS:000288373500010
PM 24014930
ER
PT J
AU Pearson, LN
Kusanovic, JP
Romero, R
Strauss, JF
Shriver, MD
AF Pearson, Laurel N.
Kusanovic, Juan Pedro
Romero, Roberto
Strauss, Jerome F., III
Shriver, Mark D.
TI Using tests for signatures of selection to validate and prioritize
admixture mapping results
SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
LA English
DT Meeting Abstract
CT 80th Annual Meeting of the
American-Association-of-Physical-Anthropologists
CY APR 11-16, 2011
CL Minneapolis, MN
SP Amer Assoc Phys Anthropol
C1 [Pearson, Laurel N.; Shriver, Mark D.] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
[Kusanovic, Juan Pedro; Romero, Roberto] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Bethesda, MD USA.
[Strauss, Jerome F., III] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23284 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-9483
J9 AM J PHYS ANTHROPOL
JI Am. J. Phys. Anthropol.
PY 2011
VL 144
SU 52
BP 236
EP 236
PG 1
WC Anthropology; Evolutionary Biology
SC Anthropology; Evolutionary Biology
GA 730LE
UT WOS:000288034000643
ER
PT J
AU Schwandt, ML
Nash, LT
Marzke, MW
AF Schwandt, Melanie L.
Nash, Leanne T.
Marzke, Mary W.
TI Growth, behavior, and morphology: lessons from chimpanzees.
SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
LA English
DT Meeting Abstract
CT 80th Annual Meeting of the
American-Association-of-Physical-Anthropologists
CY APR 11-16, 2011
CL Minneapolis, MN
SP Amer Assoc Phys Anthropol
C1 [Schwandt, Melanie L.] NIH, Bethesda, MD 20892 USA.
[Nash, Leanne T.; Marzke, Mary W.] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-9483
J9 AM J PHYS ANTHROPOL
JI Am. J. Phys. Anthropol.
PY 2011
VL 144
SU 52
BP 267
EP 267
PG 1
WC Anthropology; Evolutionary Biology
SC Anthropology; Evolutionary Biology
GA 730LE
UT WOS:000288034000760
ER
PT J
AU Li, Y
Graubard, BI
DiGaetano, R
AF Li, Yan
Graubard, Barry I.
DiGaetano, Ralph
TI Weighting methods for population-based case-control studies with complex
sampling
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
LA English
DT Article
DE Analysis of survey data; Complex survey; Frequency matching;
Post-stratification
ID STRATIFIED CASE-CONTROL; LOGISTIC-REGRESSION; MAXIMUM-LIKELIHOOD; MODELS
AB Complex sample designs, involving stratified and/or multistage sampling with sample weighting, along with frequency matching, are used to select controls or cases for case-control studies. Examples that motivated this paper are the Kaposi sarcoma case-control study that was conducted in Sicily and the US kidney cancer case-control study. Survey design-based approaches can be inefficient for the analysis of case-control studies with frequency matching. We propose a weighting method that post-stratifies control sample weights to the estimated population distribution of the matching variables among cases. This weighting maintains the efficiency of frequency matching. The method proposed is evaluated by using simulation studies and is applied to the two case-control studies.
C1 [Li, Yan] Univ Texas Arlington, Dept Math, Arlington, TX 76019 USA.
[Li, Yan; Graubard, Barry I.] NCI, Bethesda, MD 20892 USA.
[DiGaetano, Ralph] WESTAT Corp, Rockville, MD 20850 USA.
RP Li, Y (reprint author), Univ Texas Arlington, Dept Math, Room 438,Pickard Hall, Arlington, TX 76019 USA.
EM liyanna@uta.edu
NR 33
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Z9 9
U1 2
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0035-9254
J9 J R STAT SOC C-APPL
JI J. R. Stat. Soc. Ser. C-Appl. Stat.
PY 2011
VL 60
BP 165
EP 185
DI 10.1111/j.1467-9876.2010.00731.x
PN 2
PG 21
WC Statistics & Probability
SC Mathematics
GA 730EX
UT WOS:000288017300002
ER
PT J
AU Phillips, KA
Epstein, DH
Vahabzadeh, M
Lin, JL
Preston, KL
AF Phillips, K. A.
Epstein, D. H.
Vahabzadeh, M.
Lin, J. L.
Preston, K. L.
TI Hour-by-Hour Cocaine Use Patterns and the Relationship to Work Status
and Structure
SO SUBSTANCE ABUSE
LA English
DT Meeting Abstract
C1 [Phillips, K. A.; Epstein, D. H.; Preston, K. L.] Natl Inst Drug Abuse, Treatment Sect, Intramural Res Program, NIH, Bethesda, MD USA.
[Vahabzadeh, M.; Lin, J. L.] Natl Inst Drug Abuse, Biomed Informat Sect, Intramural Res Program, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0889-7077
J9 SUBST ABUS
JI Subst. Abus.
PY 2011
VL 32
IS 1
BP 56
EP 56
PG 1
WC Substance Abuse
SC Substance Abuse
GA 717GE
UT WOS:000287030800028
ER
PT J
AU Li, H
He, JT
Liu, Q
Huo, ZH
Liang, S
Liang, Y
Ito, Y
AF Li, Hang
He, Junting
Liu, Qin
Huo, Zhaohui
Liang, Si
Liang, Yong
Ito, Yoichiro
TI Simultaneous Determination of Hydrochlorothiazide and Reserpine in Human
Urine by LC with a Simple Pre-Treatment
SO CHROMATOGRAPHIA
LA English
DT Article
DE Column liquid chromatography; Sample pre-treatment; Hydrochlorothiazide
and reserpine in urine
ID CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY; HUMAN PLASMA;
LIQUID-CHROMATOGRAPHY; SPECTROFLUOROMETRIC DETERMINATION; TABLETS; HPLC
AB A simple, selective and sensitive reversed-phase liquid chromatography method for simultaneous analysis of hydrochlorothiazide and reserpine in human urine was developed and subjected to primary pharmacokinetic study. After a simple protein precipitation using methanol and extraction with ethyl acetate, the analytes were separated on an Elite C(18) column at a flow rate of 0.8 mL min(-1). The mobile phase was composed of acetonitrile (A) and 0.2% ammonium chloride solution (B) for a gradient elution starting at A:B at 30:70, v/v for 0-6 min, linearly raising the percent of A from 30 to 50% (6-9 min) and ending at 50:50, v/v (9-25 min). The standard curves were linear over the range of 0.05-20 mu g mL(-1) for hydrochlorothiazide and 0.02-5.0 mu g mL(-1) for reserpine, respectively (r > 0.999). The limit of detection (LOD) and the limit of quantification (LOQ) were 5.5 and 18.2 ng mL(-1) for hydrochlorothiazide, and 7.1 and 23.6 ng mL(-1) for reserpine, respectively. The recoveries for both analytes were above 89 +/- A 1.35%. The intra-day and inter-day precision for hydrochlorothiazide were less than 1.91 and 1.38%, and those for reserpine were below 1.61 and 2.64%, respectively. The method indicated good performance in terms of specificity, linearity, detection and quantification limits, precision and accuracy, and was employed successfully for the simultaneous determination of hydrochlorothiazide and reserpine in human urine samples.
C1 [Li, Hang; He, Junting; Liu, Qin; Huo, Zhaohui; Liang, Si; Liang, Yong] S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China.
[Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
RP Liang, Y (reprint author), S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China.
EM liangy@scnu.edu.cn
FU Intramural NIH HHS [Z99 HL999999]
NR 17
TC 5
Z9 6
U1 0
U2 9
PU VIEWEG
PI WIESBADEN
PA ABRAHAM-LINCOLN-STRABE 46, POSTFACH 15 47, D-65005 WIESBADEN, GERMANY
SN 0009-5893
J9 CHROMATOGRAPHIA
JI Chromatographia
PD JAN
PY 2011
VL 73
IS 1-2
BP 171
EP 175
DI 10.1007/s10337-010-1821-5
PG 5
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 712MI
UT WOS:000286670500024
PM 21297934
ER
PT J
AU Liu, XD
Sun, LG
Li, D
Wang, YH
AF Liu, Xiaodong
Sun, Liguang
Li, Dan
Wang, Yuhong
TI Rare earth elements in the ornithogenic sediments from the Maritime
Antarctic: A potential new palaeoecology proxy
SO GEOCHEMICAL JOURNAL
LA English
DT Article
DE Antarctica; ornithogenic sediments; rare earth elements; palaeoecology;
penguin population
ID ABANDONED PENGUIN COLONIES; KING-GEORGE-ISLAND; EAST ANTARCTICA;
LAKE-SEDIMENTS; CLIMATE-CHANGE; LATE-HOLOCENE; PENINSULA; GEOCHEMISTRY;
RECORD; ADELIE
AB The ornithogenic sediments in the maritime Antarctic are good archives for studying the changes of historical penguin population. Rare earth elements (REEs) along with biological and lithophile elements in two lacustrine sediment cores (Y2 and Y4) influenced by penguin droppings were analyzed with the aim of evaluating their potential as a new palaeoecological proxy. The relative concentrations of REEs in the two cores show dramatic changes, and the average REE contents are 71.21 +/- 11.56 (n = 37) and 37.18 +/- 10.64 (n = 18) for Y2 and Y4, respectively. The REE light/heavy content ratios (L/H) are 4.48 +/- 0.59 for Y2 and 4.70 +/- 0.62 for Y4, very close to the mean ratio of four pure guano samples. The chondrite-normalized REE patterns in the Y2 and Y4 sediments significantly influenced by penguin droppings are characteristic of more fractionation, obviously negative Ce anomalies and positive Er anomalies, likely imprinting the REE signal of guano input. The total REE concentration has a statistically significant negative correlation with the levels of guano-derived bio- elements and a positive correlation with the levels of Sc and Al mainly originated from weathered soils. The calculated proportion of guano-derived REE based on two-member mixing equation has a change pattern consistent with that of the historical penguin population size, previously reconstructed from bio-element concentrations in the sediments. These results suggest that the non-crustal signature of REE in the ornithogenic sediments may provide a new palaeoecological proxy for studying the palaeoecological processes of Antarctic penguins on a large time scale.
C1 [Liu, Xiaodong; Sun, Liguang; Li, Dan] Univ Sci & Technol China, Inst Polar Environm, Hefei 230026, Anhui, Peoples R China.
[Wang, Yuhong] NIH, Bethesda, MD 20892 USA.
RP Liu, XD (reprint author), Univ Sci & Technol China, Inst Polar Environm, Hefei 230026, Anhui, Peoples R China.
EM ycx@ustc.edu.cn
FU Polar Office of National Oceanic Bureau of China; National Natural
Science Foundation [0876096, 41076123, 40606003, 40730107]; CAAA
[20070202]; SOA Key Laboratory for Polar Science [KP2007002]; CAS
FX We would like to thank Polar Office of National Oceanic Bureau of China
for support and assistance. This study was supported by the National
Natural Science Foundation (Grant Nos. 40876096, 41076123, 40606003 and
40730107), the young fund for strategetic research of Chinese polar
sciences from CAAA (No. 20070202), open research fund from SOA Key
Laboratory for Polar Science (KP2007002) and special fund for excellent
Ph.D. Thesis of CAS. We especially appreciate three anonymous reviewers
for their critical reviews and careful corrections on this manuscript.
NR 48
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U1 4
U2 17
PU GEOCHEMICAL SOC JAPAN
PI TOKYO
PA 358-5 YAMABUKI-CHO, SHINJUKU-KU, TOKYO, 162-0801, JAPAN
SN 0016-7002
EI 1880-5973
J9 GEOCHEM J
JI Geochem. J.
PY 2011
VL 45
IS 1
BP 15
EP 26
PG 12
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 728QY
UT WOS:000287890800002
ER
PT J
AU Specht, A
Fiske, L
Erger, K
Cossette, T
Verstegen, J
Campbell-Thompson, M
Struck, MB
Lee, YM
Chou, JY
Byrne, BJ
Correia, CE
Mah, CS
Weinstein, DA
Conlon, TJ
AF Specht, Andrew
Fiske, Laurie
Erger, Kirsten
Cossette, Travis
Verstegen, John
Campbell-Thompson, Martha
Struck, Maggie B.
Lee, Young Mok
Chou, Janice Y.
Byrne, Barry J.
Correia, Catherine E.
Mah, Cathryn S.
Weinstein, David A.
Conlon, Thomas J.
TI Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic
and Genetic Liver Disease
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID UNCOOKED CORNSTARCH; GLUCOSE-6-PHOSPHATASE GENE; CONTINUOUS GLUCOSE;
CLINICAL COURSE; MUTATIONS; THERAPY; 1A; MANAGEMENT; GROWTH;
IDENTIFICATION
AB A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-alpha. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model are described and compared to those observed in humans. The canine model shows more complete recapitulation of the clinical manifestations seen in humans including "lactic acidosis", larger size, and longer lifespan compared to other animal models. Use of this model in preclinical trials of gene therapy is described and briefly compared to the murine model. Although the canine model offers a number of advantages for evaluating potential therapies for GSDIa, there are also some significant challenges involved in its use. Despite these challenges, the canine model of GSDIa should continue to provide valuable information about the potential for generating curative therapies for GSDIa as well as other genetic hepatic diseases.
C1 [Erger, Kirsten; Cossette, Travis; Byrne, Barry J.; Mah, Cathryn S.; Conlon, Thomas J.] Univ Florida, Powell Gene Therapy Ctr, Gainesville, FL 32610 USA.
[Specht, Andrew] Univ Florida, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
[Fiske, Laurie; Correia, Catherine E.; Weinstein, David A.] Univ Florida, Div Pediat Endocrinol, Dept Pediat, Glycogen Storage Dis Program, Gainesville, FL 32610 USA.
[Verstegen, John] Univ Florida, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA.
[Campbell-Thompson, Martha] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA.
[Struck, Maggie B.] Univ Florida, Anim Care Serv, Gainesville, FL 32610 USA.
[Lee, Young Mok; Chou, Janice Y.] NICHHD, Sect Cellular Differentiat, PDEGEN, NIH, Bethesda, MD 20892 USA.
[Byrne, Barry J.; Mah, Cathryn S.] Univ Florida, Div Cellular & Mol Therapy, Dept Pediat, Gainesville, FL 32610 USA.
[Conlon, Thomas J.] Univ Florida, Dept Pediat, Coll Med, Gainesville, FL 32610 USA.
RP Conlon, TJ (reprint author), Univ Florida, Powell Gene Therapy Ctr, Gainesville, FL 32610 USA.
EM conlon@peds.ufl.edu
OI Campbell-Thompson, Martha/0000-0001-6878-1235
FU Children's Fund for Glycogen Storage Disease Research; Children's
Miracle Network; National Institutes of Health [NHLBI P01 HL59412-06,
NIDDK P01 DK58327-03]; Scott Miller Glycogen Storage Disease Program
Fund; Matthew Ehrman GSD Research Fund; Type Ib Glycogen Storage Disease
Fund; Jonah Pournazarian Type Ib GSD Fund; Green Family Fund for GSD
Research; HLH Fund; Canadian Fund for the Cure of GSD
FX The authors gratefully acknowledge the UF GSD Puppy Care Team and the
University of Florida Animal Care Services and College of Veterinary
Medicine Veterinary Staff for their assistance in animal care; they also
acknowledge the University of Florida Molecular Pathology Core; and the
University of Florida Powell Gene Therapy Center Toxicology Core. This
work was supported by Grants from the Children's Fund for Glycogen
Storage Disease Research, the Children's Miracle Network, and the
National Institutes of Health (nos. NHLBI P01 HL59412-06, NIDDK P01
DK58327-03). Additional philanthropic support was provided from the
Scott Miller Glycogen Storage Disease Program Fund, Matthew Ehrman GSD
Research Fund, the Type Ib Glycogen Storage Disease Fund, the Jonah
Pournazarian Type Ib GSD Fund, Green Family Fund for GSD Research, HLH
Fund, and the Canadian Fund for the Cure of GSD. B. J. Byrne the Johns
Hopkins University, and the University of Florida could be entitled to
patent royalties for inventions described in this paper. D. A. Weinstein
and T. Cossette share senior authorship for this work.
NR 40
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U1 0
U2 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 646257
DI 10.1155/2011/646257
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 728PC
UT WOS:000287885000001
ER
PT J
AU Jia, L
Zhao, YL
Liang, XJ
AF Jia, Lee
Zhao, Yuliang
Liang, Xing-Jie
TI Fast evolving nanotechnology and relevant programs and entities in China
SO NANO TODAY
LA English
DT Article
DE Nanotechnology; Nanomaterials; Nanoscience; Nanosafety
ID SCIENCE; RUSSIA
AB In recent years, facing serious global competition, the Chinese government has focused on accelerating the growth of the advanced technology sector including nanotechnology in order to lift the country's status from manufacturing raw materials and goods up to innovation technology, information economy and green efficient energy. With trillions in tangible monetary reserves, the government has substantially increased its investment in nanotechnology through several major initiatives. These measures comprise tax incentives and low rents for new facilities within economic development parks to stimulate the growth of new nanotechnology-related companies and attract foreign investment. This article outlines some of the current nanotechnology businesses, programs and markets across China, including its technology focus, collaborations, geography, and funding from central and local governments and from the private sector. Efforts are being made in China to increase the number and quality of nanotechnology-related publications and patents, and to pursue industrial-scale production of nanomaterials with the intention of opening up opportunities for new businesses to sprout and grow. Watching China's shift to a nation that promotes innovation will be an exciting time for the global nanotechnology community. It is hoped that R&D and commercial applications of nanomaterials and nanotechnology will provide new impetus for faltering economies. Published by Elsevier Ltd.
C1 [Jia, Lee] NCI, NIH, Rockville, MD 20852 USA.
[Zhao, Yuliang; Liang, Xing-Jie] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
RP Jia, L (reprint author), Dev Therapeut Program, Execut Plaza N,Room 8042,6130 Execut Blvd,MSC 745, Rockville, MD 20852 USA.
EM jiale@mail.nih.gov
NR 16
TC 11
Z9 12
U1 2
U2 28
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-0132
J9 NANO TODAY
JI Nano Today
PY 2011
VL 6
IS 1
BP 6
EP 11
DI 10.1016/j.nantod.2010.11.003
PG 6
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 729NT
UT WOS:000287958200005
ER
PT J
AU Rahbar, A
Rivers, R
Boja, E
Kinsinger, C
Mesri, M
Hiltke, T
Rodriguez, H
AF Rahbar, Amir
Rivers, Robert
Boja, Emily
Kinsinger, Christopher
Mesri, Mehdi
Hiltke, Tara
Rodriguez, Henry
TI Realizing individualized medicine: the road to translating proteomics
from the laboratory to the clinic
SO PERSONALIZED MEDICINE
LA English
DT Review
DE biomarkers; diagnostics; enzyme-linked immunosorbent assay;
individualized medicine; mass spectrometry; proteins; proteomics
ID TANDEM MASS-SPECTROMETRY; CELL LUNG-CANCER; LINKED-IMMUNOSORBENT-ASSAY;
ANTIBODY-BASED PROTEOMICS; LIQUID-CHROMATOGRAPHY; QUANTITATIVE-ANALYSIS;
BIOMARKER DISCOVERY; NEXT-GENERATION; PLASMA PROTEOME; FUTURE FIELDS
AB The sequencing of the human genome has brought great promise and potential for the future of medicine, as well as providing a strong momentum for the burgeoning field of individualized medicine. Tests based on genetic information can be used to allow physicians to target therapies for those patients most likely to benefit from specific therapies and identify potential risk before the onset of disease. While advances in genomics-based molecular diagnostics are progressing, producing some useful US FDA-approved/-cleared diagnostic tests, protein-based molecular diagnostics have not met its promised potential. This article will provide an overview of protein-based analysis technologies, identify their strengths and limitations, discuss barriers to protein-based biomarker development and identify issues which must be addressed in order to successfully transfer the field of proteomics from the laboratory to the clinic.
C1 [Rahbar, Amir; Rivers, Robert; Boja, Emily; Kinsinger, Christopher; Mesri, Mehdi; Hiltke, Tara; Rodriguez, Henry] NCI, Off Canc Clin Proteom Res, Ctr Strateg Sci Initiat, NIH, Bethesda, MD 20892 USA.
RP Rodriguez, H (reprint author), NCI, Off Canc Clin Proteom Res, Ctr Strateg Sci Initiat, NIH, 31 Ctr Dr, Bethesda, MD 20892 USA.
EM rodriguezh@mail.nih.gov
RI Mendez, Pedro /J-8955-2016
OI Mendez, Pedro /0000-0001-6713-7907
NR 91
TC 2
Z9 3
U1 0
U2 1
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1741-0541
J9 PERS MED
JI Pers. Med.
PD JAN
PY 2011
VL 8
IS 1
BP 45
EP 57
DI 10.2217/PME.10.76
PG 13
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 716HY
UT WOS:000286960900011
ER
PT J
AU Amaruchkul, K
Cooper, WL
Gupta, D
AF Amaruchkul, Kannapha
Cooper, William L.
Gupta, Diwakar
TI A Note on Air-Cargo Capacity Contracts
SO PRODUCTION AND OPERATIONS MANAGEMENT
LA English
DT Article
DE capacity contracts; asymmetric information; informational rents
ID SUPPLY CONTRACTS; INFORMATION; ALLOCATION; MECHANISMS; DEMANDS
AB Carriers (airlines) use medium-term contracts to allot bulk cargo capacity to forwarders who deliver consolidated loads for each flight in the contractual period (season). Carriers also sell capacity to direct-ship customers on each flight. We study capacity contracts between a carrier and a forwarder when certain parameters such as the forwarder's demand, operating cost to the carrier, margin, and reservation profit are its private information. We propose contracts in which the forwarder pays a lump sum in exchange for a guaranteed capacity allotment and receives a refund for each unit of unused capacity according to a pre-announced refund rate. We obtain an upper bound on the informational rent paid by the carrier for a menu of arbitrary allotments and identify conditions under which it can eliminate the informational rent and induce the forwarder to choose the overall optimal capacity allotment (i.e., one that maximizes the combined profits of the carrier and the forwarder).
C1 [Amaruchkul, Kannapha] NIDA, Sch Appl Stat, Bangkok 10240, Thailand.
[Cooper, William L.; Gupta, Diwakar] Univ Minnesota, Program Ind & Syst Engn, Minneapolis, MN 55455 USA.
RP Amaruchkul, K (reprint author), NIDA, Sch Appl Stat, Bangkok 10240, Thailand.
EM kamaruchkul@gmail.com; billcoop@me.umn.edu; guptad@me.umn.edu
FU National Science Foundation [DMI-0450359]
FX This material is based on work supported, in part, by the National
Science Foundation under Grant No. DMI-0450359. The authors are grateful
to the referees and the senior editor for their constructive comments on
an earlier version of this paper.
NR 27
TC 8
Z9 9
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1059-1478
J9 PROD OPER MANAG
JI Prod. Oper. Manag.
PD JAN-FEB
PY 2011
VL 20
IS 1
BP 152
EP 162
DI 10.1111/j.1937-5956.2010.01158.x
PG 11
WC Engineering, Manufacturing; Operations Research & Management Science
SC Engineering; Operations Research & Management Science
GA 701PJ
UT WOS:000285832900012
ER
PT J
AU Kirkpatrick, B
Fleming, LE
Bean, JA
Nierenberg, K
Backer, LC
Cheng, YS
Pierce, R
Reich, A
Naar, J
Wanner, A
Abraham, WM
Zhou, Y
Hollenbeck, J
Baden, DG
AF Kirkpatrick, Barbara
Fleming, Lora E.
Bean, Judy A.
Nierenberg, Kate
Backer, Lorraine C.
Cheng, Yung Sung
Pierce, Richard
Reich, Andrew
Naar, Jerome
Wanner, Adam
Abraham, William M.
Zhou, Yue
Hollenbeck, Julie
Baden, Daniel G.
TI Aerosolized red tide toxins (brevetoxins) and asthma: Continued health
effects after 1 h beach exposure
SO HARMFUL ALGAE
LA English
DT Article
DE Coastal; Harmful algal blooms (HABs); Inhalation toxicity; Karenia
brevis
ID MARINE AEROSOL; FLORIDA; BREVIS
AB Blooms of the toxic dinoflagellate. Karenia brevis, produce potent neurotoxins in marine aerosols. Recent studies have demonstrated acute changes in both symptoms and pulmonary function in asthmatics after only 1 h of beach exposure to these aerosols. This study investigated if there were latent and/or sustained effects in asthmatics in the days following the initial beach exposure during periods with and without an active Florida red tide.
Symptom data and spirometry data were collected before and after 1 h of beach exposure. Subjects kept daily symptom diaries and measured their peak flow each morning for 5 days following beach exposure. During non-exposure periods, there were no significant changes in symptoms or pulmonary function either acutely or over 5 days of follow-up. After the beach exposure during an active Florida red tide, subjects had elevated mean symptoms which did not return to the pre-exposure baseline for at least 4 days. The peak flow measurements decreased after the initial beach exposure, decreased further within 24 h, and continued to be suppressed even after 5 days. Asthmatics may continue to have increased symptoms and delayed respiratory function suppression for several days after 1 h of exposure to the Florida red tide toxin aerosols. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Kirkpatrick, Barbara; Nierenberg, Kate; Pierce, Richard] Mote Marine Lab, Sarasota, FL 34236 USA.
[Fleming, Lora E.; Hollenbeck, Julie] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NSF, Miami, FL 33149 USA.
[Fleming, Lora E.; Hollenbeck, Julie] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NIEHS Oceans & Human Hlth Ctr, Miami, FL 33149 USA.
[Fleming, Lora E.; Wanner, Adam] Univ Miami, Sch Med, Miami, FL 33136 USA.
[Bean, Judy A.] Childrens Hosp Med Ctr, Cincinnati, OH USA.
[Bean, Judy A.] Univ Cincinnati, Cincinnati, OH USA.
[Backer, Lorraine C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Cheng, Yung Sung] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA.
[Reich, Andrew] Florida Dept Hlth, Tallahassee, FL 32399 USA.
[Naar, Jerome; Baden, Daniel G.] Univ N Carolina, Ctr Marine Sci, Wilmington, NC 28409 USA.
[Abraham, William M.] Mt Sinai Med Ctr, Miami Beach, FL 33140 USA.
RP Fleming, LE (reprint author), Publ Hlth Univ Miami, Sch Med, Dept Epidemiol, Clin Res Bldg CRB,10th Floor,1120 NW 14th S, Miami, FL 33136 USA.
EM lfleming@med.miami.edu
FU National Institute of Environmental Health Sciences (NIEHS) [P01 ES
10594, 1 P50 ES12736]; Centers for Disease Control and Prevention (CDC);
Florida Department of Health; Florida Dept of Environmental Protection
(FL DEP) Florida Red Tide Control and Mitigation; National Science
Foundation (NSF); National Institute of Environmental Health Sciences
(NIEHS) Oceans and Human Health Center at the University of Miami
Rosenstiel School [NSF] [NSF OCE0432368, NSF OCE0911373]
FX This research was supported by the National Institute of Environmental
Health Sciences (NIEHS) Aerosolized Florida Red Tide PO1 [P01 ES 10594]
with a Minority Supplement, as well as by the Centers for Disease
Control and Prevention (CDC), and the Florida Department of Health.
Additional support was received from the Florida Dept of Environmental
Protection (FL DEP) Florida Red Tide Control and Mitigation; the
National Science Foundation (NSF) and the National Institute of
Environmental Health Sciences (NIEHS) Oceans and Human Health Center at
the University of Miami Rosenstiel School [NSF OCE0432368 and NSF
OCE0911373];[NIEHS 1 P50 ES12736].[SS]
NR 24
TC 11
Z9 11
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-9883
J9 HARMFUL ALGAE
JI Harmful Algae
PD JAN
PY 2011
VL 10
IS 2
BP 138
EP 143
DI 10.1016/j.hal.2010.08.005
PG 6
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 714XP
UT WOS:000286845300003
PM 21499552
ER
PT J
AU Chang, R
Lozier, JN
Horne, MK
AF Chang, R.
Lozier, J. N.
Horne, M. K., III
TI Thrombolytic Therapy with Tissue Plasminogen Activator: Why Prolonged
Continuous Infusion is not the Best Approach
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Meeting Abstract
CT 5th Annual Academic Surgical Congress
CY FEB 03-05, 2010
CL San Antonio, TX
SP Assoc Acad Surg, Soc Univ Surg
C1 [Chang, R.; Lozier, J. N.; Horne, M. K., III] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JAN
PY 2011
VL 53
IS 1
BP 260
EP 260
DI 10.1016/j.jvs.2010.11.027
PG 1
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA 704WB
UT WOS:000286085200067
ER
PT J
AU Mukai, I
Bahadur, K
Kesavabhotla, K
Ungerleider, LG
AF Mukai, Ikuko
Bahadur, Kandy
Kesavabhotla, Kartik
Ungerleider, Leslie G.
TI Exogenous and endogenous attention during perceptual learning
differentially affect post-training target thresholds
SO JOURNAL OF VISION
LA English
DT Article
DE perceptual learning; exogenous attention; endogenous attention; contrast
threshold; Gabor patch
ID PRIMARY VISUAL-CORTEX; CONTRAST RESPONSE FUNCTIONS; SELECTIVE ATTENTION;
STAIRCASE-METHOD; TIME-COURSE; DISCRIMINATION; ORIENTATION;
PSYCHOPHYSICS; SPECIFICITY; MECHANISMS
AB There is conflicting evidence in the literature regarding the role played by attention in perceptual learning. To further examine this issue, we independently manipulated exogenous and endogenous attention and measured the rate of perceptual learning of oriented Gabor patches presented in different quadrants of the visual field. In this way, we could track learning at attended, divided-attended, and unattended locations. We also measured contrast thresholds of the Gabor patches before and after training. Our results showed that, for both exogenous and endogenous attention, accuracy in performing the orientation discrimination improved to a greater extent at attended than at unattended locations. Importantly, however, only exogenous attention resulted in improved contrast thresholds. These findings suggest that both exogenous and endogenous attention facilitate perceptual learning, but that these two types of attention may be mediated by different neural mechanisms.
C1 [Mukai, Ikuko; Bahadur, Kandy; Kesavabhotla, Kartik; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
RP Mukai, I (reprint author), NIMH, Lab Brain & Cognit, NIH, Bldg 10,Room 4C104,10 Ctr Dr, Bethesda, MD 20892 USA.
EM mukaii@mail.nih.gov
FU National Institutes of Health-National Institute of Mental Health
FX This work was supported by the Intramural Research Program of the
National Institutes of Health-National Institute of Mental Health. We
Thank Dr. John Ingeholm for providing technical support for the eye
tracker, Dr. Gang Chen for giving us valuable comments on the
statistical analyses, and Olivia Wu for assistance with data collection.
NR 61
TC 3
Z9 3
U1 0
U2 8
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 1534-7362
J9 J VISION
JI J. Vision
PY 2011
VL 11
IS 1
AR 25
DI 10.1167/11.1.25
PG 15
WC Ophthalmology
SC Ophthalmology
GA 726OI
UT WOS:000287732900025
ER
PT J
AU Helman, LJ
AF Helman, L. J.
TI Targeting the IGF1 Pathway in Pediatric Sarcomas
SO KLINISCHE PADIATRIE
LA English
DT Meeting Abstract
C1 [Helman, L. J.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0300-8630
J9 KLIN PADIATR
JI Klinische Padiatr.
PD JAN
PY 2011
VL 223
IS 1
MA 3
BP 46
EP 46
DI 10.1055/s-0030-1270296
PG 1
WC Pediatrics
SC Pediatrics
GA 725ED
UT WOS:000287627100015
ER
PT J
AU Chen, HL
Gao, XA
Ascherio, A
AF Chen, Honglei
Gao, Xiang
Ascherio, Alberto
TI Prospective Research on Parkinson Nonmotor Symptoms
SO ARCHIVES OF NEUROLOGY
LA English
DT Letter
ID DISEASE; RISK
C1 [Chen, Honglei] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Gao, Xiang; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA.
RP Chen, HL (reprint author), NIEHS, Epidemiol Branch, Mail Drop A3-05,111 TW Alexander Dr,Rall Bldg 101, Res Triangle Pk, NC 27709 USA.
EM chenh2@niehs.nih.gov
OI Chen, Honglei/0000-0003-3446-7779
NR 6
TC 2
Z9 2
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0003-9942
J9 ARCH NEUROL-CHICAGO
JI Arch. Neurol.
PD JAN
PY 2011
VL 68
IS 1
BP 137
EP 137
DI 10.1001/archneurol.2010.332
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 704MO
UT WOS:000286057300026
PM 21220690
ER
PT J
AU Vexler, A
Liu, SL
Schisterman, EF
AF Vexler, Albert
Liu, Shuling
Schisterman, Enrique F.
TI Nonparametric-likelihood inference based on
cost-effectively-sampled-data
SO JOURNAL OF APPLIED STATISTICS
LA English
DT Article
DE confidence interval; cost-efficient design; empirical likelihood;
nonparametric method; pooling design; power; random sampling; Student's
t-test; type-I error
ID ROC CURVE ANALYSIS; EMPIRICAL LIKELIHOOD; POOLED ASSESSMENTS;
DIAGNOSTIC-ACCURACY; BIOMARKERS; BIOSPECIMENS; SUBJECT; LIMIT
AB Costs associated with the evaluation of biomarkers can restrict the number of relevant biological samples to be measured. This common problem has been dealt with extensively in the epidemiologic and biostatistical literature that proposes to apply different cost-efficient procedures, including pooling and random sampling strategies. The pooling design has been widely addressed as a very efficient sampling method under certain parametric assumptions regarding data distribution. When cost is not a main factor in the evaluation of biomarkers but measurement is subject to a limit of detection, a common instrument limitation on the measurement process, the pooling design can partially overcome this instrumental limitation. In certain situations, the pooling design can provide data that is less informative than a simple random sample; however this is not always the case. Pooled-data-based nonparametric inferences have not been well addressed in the literature. In this article, a distribution-free method based on the empirical likelihood technique is proposed to substitute the traditional parametric-likelihood approach, providing the true coverage, confidence interval estimation and powerful tests based on data obtained after the cost-efficient designs. We also consider several nonparametric tests to compare with the proposed procedure. We examine the proposed methodology via a broad Monte Carlo study and a real data example.
C1 [Vexler, Albert; Liu, Shuling] SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA.
[Schisterman, Enrique F.] NICHHD, Div Epidemiol Stat & Prevent Res, NIH, DHHS, Rockville, MD USA.
RP Vexler, A (reprint author), SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA.
EM avexler@buffalo.edu
OI Schisterman, Enrique/0000-0003-3757-641X
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development
FX This work was supported in part with funding from the Intramural
Research Program of the Eunice Kennedy Shriver National Institute of
Child Health and Human Development. The authors thank the reviewers for
their insightful comments that have greatly helped us improve the
article.
NR 19
TC 5
Z9 5
U1 1
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0266-4763
J9 J APPL STAT
JI J. Appl. Stat.
PY 2011
VL 38
IS 4
BP 769
EP 783
DI 10.1080/02664761003692290
PG 15
WC Statistics & Probability
SC Mathematics
GA 717CP
UT WOS:000287020600010
ER
PT J
AU Taylor, J
Mariotti, J
Fowler, DH
AF Taylor, J.
Mariotti, J.
Fowler, D. H.
TI THE PENTOSTATIN PLUS CYCLOPHOSPHAMIDE (PC) NON-MYELOABLATIVE REGIMEN
INDUCES DURABLE HOST T CELL FUNCTIONAL DEFICITS AND PREVENTS MARROW
ALLOGRAFT REJECTION
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
C1 [Taylor, J.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA.
[Taylor, J.; Mariotti, J.; Fowler, D. H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD JAN
PY 2011
VL 59
IS 1
MA 100
BP 116
EP 116
PG 1
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 697TZ
UT WOS:000285542500115
ER
PT J
AU Dolan, JG
Wan, X
Yeung, C
Helman, LJ
AF Dolan, J. G.
Wan, X.
Yeung, C.
Helman, L. J.
TI TARGETING FOXM1 TRANSCRIPTION FACTOR IN RHABDOMYOSARCOMA
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
C1 [Dolan, J. G.] Univ Washington, Sch Med, Seattle, WA USA.
[Wan, X.; Yeung, C.; Helman, L. J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD JAN
PY 2011
VL 59
IS 1
MA 342
BP 183
EP 183
PG 1
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 697TZ
UT WOS:000285542500357
ER
PT J
AU Shinomiya, K
Kobayashi, H
Inokuchi, N
Nakagomi, K
Ito, Y
AF Shinomiya, Kazufusa
Kobayashi, Hiroko
Inokuchi, Norio
Nakagomi, Kazuya
Ito, Yoichiro
TI PARTITION EFFICIENCY OF HIGH-PITCH LOCULAR MULTILAYER COIL FOR
COUNTERCURRENT CHROMATOGRAPHIC SEPARATION OF PROTEINS USING SMALL-SCALE
CROSS-AXIS COIL PLANET CENTRIFUGE AND APPLICATION TO PURIFICATION OF
VARIOUS COLLAGENASES WITH AQUEOUS-AQUEOUS POLYMER PHASE SYSTEMS
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE collagenases; countercurrent chromatography; cross-axis coil planet
centrifuge; high-pitch multilayer coil; locular tubing; polymer phase
system; proteins; purification
ID ROTARY SEALS; APPARATUS; ASSEMBLIES; COLUMNS; DESIGN
AB Partition efficiency of the high-pitch locular multilayer coil was evaluated in countercurrent chromatographic (CCC) separation of proteins with an aqueous-aqueous polymer phase system using the small-scale cross-axis coil planet centrifuge (X-axis CPC) fabricated in our laboratory. The separation column was specially made by high-pitch (ca 5cm) winding of 1.0mm I.D., 2.0mm O.D. locular tubing compressed at 2cm intervals with a total capacity of 29.5mL. The protein separation was performed using a set of stable proteins including cytochrome C, myoglobin, and lysozyme with the 12.5% (w/w) polyethylene glycol (PEG) 1000 and 12.5% (w/w) dibasic potassium phosphate system (pH 9.2) under 1000rpm of column revolution. This high-pitch locular tubing yielded substantially higher stationary phase retention than the normal locular tubing for both lower and upper mobile phases. In order to demonstrate the capability of the high-pitch locular tubing, the purification of collagenase from the crude commercial sample was carried out using an aqueous-aqueous polymer phase system. Using the 16.0% (w/w) PEG 1000-6.3% (w/w) dibasic potassium phosphate-6.3% (w/w) monobasic potassium phosphate system (pH 6.6), collagenase I, II, IV, V, and X derived from Clostridium histolyticum were separated from other proteins and colored small molecular weight compounds present in the crude commercial sample. Collagenase from C. histolyticum well retained its enzymatic activity in the purified fractions. The overall results demonstrated that the high-pitch locular multilayer coil is effectively used for the CCC purification of bioactive compounds without loss of their enzymatic activities.
C1 [Shinomiya, Kazufusa; Kobayashi, Hiroko; Inokuchi, Norio] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan.
[Nakagomi, Kazuya] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa, Japan.
[Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
RP Shinomiya, K (reprint author), Nihon Univ, Sch Pharm, 7-7-1 Narashinodai, Funabashi, Chiba 2748555, Japan.
EM shinomiya.kazufusa@nihon-u.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX This work was supported by a grant from the Ministry of Education,
Culture, Sports, Science, and Technology of Japan. The authors would
like to thank Mr. Kazunori Yoshida and Mr. Kazuhiro Yanagidaira (College
of Science and Technology, Nihon University, Chiba, Japan) for their
technical assistance. The authors are also indebted to Mr. Susumu
Kasahara (Takacho Co., Tokyo, Japan) for his helpful advice.
NR 17
TC 3
Z9 3
U1 1
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1082-6076
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PY 2011
VL 34
IS 3
BP 182
EP 194
AR PII 933012174
DI 10.1080/10826076.2011.546151
PG 13
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 715PA
UT WOS:000286895200003
PM 21869859
ER
PT J
AU Lee, SM
Romero, R
Lee, KA
Yang, HJ
Oh, KJ
Park, CW
Yoon, BH
AF Lee, Seung Mi
Romero, Roberto
Lee, Kyung A.
Yang, Hye Jin
Oh, Kyung Joon
Park, Chan-Wook
Yoon, Bo Hyun
TI The frequency and risk factors of funisitis and histologic
chorioamnionitis in pregnant women at term who delivered after the
spontaneous onset of labor
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE infection; inflammation; nulliparity; duration of labor; prolonged
labour; rupture of membranes; pregnancy
ID AMNIOTIC-FLUID; INTRAAMNIOTIC INFLAMMATION; CEREBRAL-PALSY;
UMBILICAL-CORD; MICROBIAL INVASION; PRETERM LABOR; INTERLEUKIN-6;
INFECTION; PLACENTA; PARTURITION
AB Objective. To examine the frequency and risk factors of funisitis and histologic chorioamnionitis in the placentas of term pregnant women who delivered after the spontaneous onset of labor.
Methods. The frequency of funisitis and histologic chorioamnionitis was examined in consecutive pregnant women at term with singleton pregnancies who delivered after the spontaneous onset of labor. Nonparametric statistics were used for data analysis.
Results. (1) The frequency of funisitis and histologic chorioamnionitis was 6.7% (88/1316) and 23.6% (310/1316), respectively; (2) Patients with funisitis had significantly higher rates of nulliparity, regional analgesia, operative vaginal delivery, longer duration of labor and rupture of membranes (ROM), and higher gestational age and birthweight than those without funisitis (p < 0.05 for each); (3) Patients with histologic chorioamnionitis had significantly higher rates of nulliparity, oxytocin augmentation, regional analgesia, cesarean section or operative vaginal delivery, longer duration of labor and ROM, and higher gestational age and birthweight than those without histologic chorioamnionitis (p < 0.05 for each); (4) Multiple logistic regression analysis indicated that the longer the duration of labor, the higher the risk of funisitis, and that nulliparity and the duration of labor significantly increased the odds of histologic chorioamnionitis (p < 0.05 for each).
Conclusion. The longer the duration of labor, the higher the risk of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor.
C1 [Lee, Seung Mi; Lee, Kyung A.; Yang, Hye Jin; Oh, Kyung Joon; Park, Chan-Wook; Yoon, Bo Hyun] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea.
[Romero, Roberto] NICHD, Perinatol Res Branch, NIH, DHHS, Detroit, MI USA.
RP Yoon, BH (reprint author), Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea.
EM yoonbh@snu.ac.kr
RI Yoon, Bo Hyun/H-6344-2011; Park, Chan-Wook/J-5498-2012
FU Korea government (MEST) [2009-0080429]; Eunice Kennedy Shriver National
Institute of Child Health and Human Development, NIH, DHHS
FX This work was supported by the National Research Foundation of Korea
(NRF) grant funded by the Korea government (MEST) (No. 2009-0080429) and
in part by the Intramural Research Program of the Eunice Kennedy Shriver
National Institute of Child Health and Human Development, NIH, DHHS.
NR 37
TC 16
Z9 16
U1 0
U2 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1476-7058
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD JAN
PY 2011
VL 24
IS 1
BP 37
EP 42
DI 10.3109/14767058.2010.482622
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 717XJ
UT WOS:000287080700004
ER
PT J
AU Flessner, MF
AF Flessner, M. F.
TI No Change in Small Molecule Transport with Prolonged Embedding of
Peritoneal Dialysis Catheters Response
SO PERITONEAL DIALYSIS INTERNATIONAL
LA English
DT Letter
C1 NIDDK, Div Kidney Urol & Hematol Dis, Bethesda, MD 20892 USA.
RP Flessner, MF (reprint author), NIDDK, Div Kidney Urol & Hematol Dis, Bethesda, MD 20892 USA.
EM flessnermf@niddk.nih.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 0896-8608
J9 PERITON DIALYSIS INT
JI Perit. Dial. Int.
PD JAN-FEB
PY 2011
VL 31
IS 1
DI 10.3747/pdi.2010.00179
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 713HN
UT WOS:000286726800023
ER
PT J
AU Starr, JM
Scollon, EJ
Hughes, MF
Graham, SE
Ross, DG
Crofton, KM
Wolansky, M
DeVito, MJ
Tornero-Velez, R
AF Starr, James M.
Scollon, Edward J.
Hughes, Michael F.
Graham, Stephen E.
Ross, David G.
Crofton, Kevin M.
Wolansky, Marcelo
DeVito, Michael J.
Tornero-Velez, Rogelio
TI Using a Chemical Mixture of Pyrethroid Pesticides to Determine Rodent
Tissue Clearance Rates
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Starr, James M.; Tornero-Velez, Rogelio] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Scollon, Edward J.; Hughes, Michael F.; Ross, David G.; Crofton, Kevin M.; Wolansky, Marcelo; DeVito, Michael J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Scollon, Edward J.] US EPA, Div Hlth Effects, Off Pesticide Programs, Arlington, VA USA.
[Graham, Stephen E.] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC USA.
[Wolansky, Marcelo] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Lab Toxicol Mezclas Quim LATOMEQ, Buenos Aires, DF, Argentina.
[DeVito, Michael J.] Natl Inst Environm Hlth Sci, Toxicol Branch, Natl Toxicol Program, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S249
EP S250
DI 10.1097/01.ede.0000392458.01615.b0
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800766
ER
PT J
AU Wang, XH
Liang, Y
Peng, CL
Xie, HC
Pan, M
Zhang, TY
Ito, Y
AF Wang, Xiaohong
Liang, Yong
Peng, Cuilin
Xie, Huichun
Pan, Man
Zhang, Tianyou
Ito, Yoichiro
TI PREPARATIVE ISOLATION AND PURIFICATION OF CHEMICAL CONSTITUENTS OF
BELAMCANDA BY MPLC, HSCCC, AND PREP-HPLC
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE Belamcanda; high-speed countercurrent chromatography; isoflavonoids;
medium-pressure liquid chromatography; preparative high-pressure liquid
chromatography
ID COUNTER-CURRENT CHROMATOGRAPHY; MASS-SPECTROMETRY; SEPARATION; CHINENSIS
AB Combined with medium-pressure liquid chromatography (MPLC) and preparative high-pressure liquid chromatography (Prep-HPLC), high-speed countercurrent chromatography (HSCCC) was successfully applied for separation and purification of isoflavonoids from the extract of belamcanda. HSCCC separation was performed on a two-phase solvent system composed of methyl tert-butyl ether-ethyl acetate-n-butyl alcohol-acetonitrile-0.1% aqueous trifluoroacetic acid at a volume radio of 1:2:1:1:5. Semi-purified peak fractions from HSCCC separation were further purified by Prep-HPLC. Nine well-separated fractions were analyzed by HPLC-UV absorption spectrometry to determine their purities and characterized with ESI-MSn. Except for peaks I and VII (unknown), seven compounds were identified as apocynin (peak II), mangiferin (peak III), 7-O-methylmangiferin (peak IV), hispidulin (peak V), 3'-hydroxyltectoridin (peak VI), iristectorin B (peak VIII), and isoiridin (peak IX).
C1 [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
[Wang, Xiaohong; Liang, Yong; Peng, Cuilin; Xie, Huichun; Pan, Man] S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou, Guangdong, Peoples R China.
[Zhang, Tianyou] Beijing Inst New Technol Applicat, Beijing, Peoples R China.
RP Ito, Y (reprint author), NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bldg 10,Room 8N230,10 Ctr Dr MSC 1762, Bethesda, MD 20892 USA.
EM itoy2@mail.nih.gov
FU Intramural NIH HHS [Z99 HL999999]
NR 12
TC 6
Z9 6
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1082-6076
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PY 2011
VL 34
IS 4
BP 241
EP 257
AR PII 932996606
DI 10.1080/10826076.2011.547058
PG 17
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 715OY
UT WOS:000286895000001
PM 21552369
ER
PT J
AU Loeb, S
Carter, HB
Schaeffer, EM
Kettermann, A
Ferrucci, L
Metter, EJ
AF Loeb, Stacy
Carter, H. Ballentine
Schaeffer, Edward M.
Kettermann, Anna
Ferrucci, Luigi
Metter, E. Jeffrey
TI Distribution of PSA Velocity by Total PSA Levels: Data From the
Baltimore Longitudinal Study of Aging REPLY
SO UROLOGY
LA English
DT Editorial Material
ID ANTIGEN VELOCITY; PROSTATE-CANCER
C1 [Loeb, Stacy; Carter, H. Ballentine; Schaeffer, Edward M.; Kettermann, Anna] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA.
[Ferrucci, Luigi; Metter, E. Jeffrey] NIA, NIH, Baltimore, MD 21224 USA.
RP Loeb, S (reprint author), Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
J9 UROLOGY
JI Urology
PD JAN
PY 2011
VL 77
IS 1
BP 148
EP 148
DI 10.1016/j.urology.2010.06.032
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 700XM
UT WOS:000285778800046
ER
PT J
AU Brzezinski, K
Tomkiel, AM
Lotowski, Z
Morzycki, J
Dauter, Z
AF Brzezinski, Krzysztof
Tomkiel, Aneta M.
Lotowski, Zenon
Morzycki, Jacek
Dauter, Zbigniew
TI Bis[3 alpha,7 alpha,12 alpha-tris(4-nitrobenzoyloxy)-5
beta-cholan-24-yl] disulfide-ethyl acetate-n-hexane (4/4/1)
SO ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
LA English
DT Article
ID BILE-ACIDS; SUPRAMOLECULAR CHEMISTRY; DERIVATIVES; STEROIDS
AB The crystal structure of the title compound, C90H100N6O24S2 center dot C4H8O2 center dot 0.25C(6)H(14), solved and refined against synchrotron diffraction data, contains two formula units in the asymmetric unit with the all-trans n-hexane molecule having half-occupancy and one of the ethyl acetate molecules disordered over two positions. The two symmetry-independent disulfide molecules are assembled by approximate face-to-face and face-to-edge interactions between their 4-nitrobenzoyloxy groups into an intertwined dimer having a double-helix-type structure. The centrally placed disulfide bridges in the two symmetry-independent molecules exhibit different helicity as shown by the C-S-S-C torsion angles of 71.0 (1) and -92.5 (1)degrees.
C1 [Brzezinski, Krzysztof; Dauter, Zbigniew] Argonne Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, Argonne, IL 60439 USA.
[Tomkiel, Aneta M.; Lotowski, Zenon; Morzycki, Jacek] Univ Bialystok, Inst Chem, PL-15443 Bialystok, Poland.
RP Brzezinski, K (reprint author), Argonne Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM kbrzezinski@anl.gov
FU University of Bialystok [BST-124]; NIH, National Cancer Institute,
Center for Cancer Research; US Department of Energy [W-31-109-Eng-38]
FX Financial support from the University of Bialystok within the project
BST-124 is gratefully acknowledged. This work was supported in part by
the Intramural Research Program of the NIH, National Cancer Institute,
Center for Cancer Research. X-ray data were collected at the NECAT
24ID-C beamline of the Advanced Photon Source, Argonne National
Laboratory. Use of the APS was supported by the US Department of Energy
under contract No. W-31-109-Eng-38.
NR 20
TC 0
Z9 0
U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1600-5368
J9 ACTA CRYSTALLOGR E
JI Acta Crystallogr. Sect. E.-Struct Rep. Online
PD JAN
PY 2011
VL 67
BP O74
EP U1990
DI 10.1107/S1600536810050385
PN 1
PG 48
WC Crystallography
SC Crystallography
GA 698XQ
UT WOS:000285628900170
ER
PT J
AU Branch, D
Zhang, J
Troendle, J
Beaver, J
AF Branch, David
Zhang, Jun
Troendle, James
Beaver, Julie
TI Current labor outcomes compared to those when I Want to Hold Your Hand
was # 1
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Branch, David] Intermt Healthcare, Salt Lake City, UT USA.
[Branch, David] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA.
[Zhang, Jun] NICHD, Bethesda, MD USA.
[Troendle, James; Beaver, Julie] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 298
BP S123
EP S123
DI 10.1016/j.ajog.2010.10.316
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500297
ER
PT J
AU Burkman, R
Gregory, K
Hoffman, M
Bailit, JL
Van Veldhusien, P
Liu, L
Branch, W
Haberman, S
Landy, H
Troendle, J
Zhang, J
Reddy, U
Hatjis, C
Wilkins, I
Kominiarek, M
Hibbard, J
Gonzalez, V
Ramirez, M
AF Burkman, Ronald
Gregory, Kimberly
Hoffman, Matthew
Bailit, Jennifer L.
Van Veldhusien, Paul
Liu, Li
Branch, Ware
Haberman, Shoshana
Landy, Helain
Troendle, James
Zhang, Jun
Reddy, Uma
Hatjis, Christos
Wilkins, Isabelle
Kominiarek, Michelle
Hibbard, Judith
Gonzalez, Victor
Ramirez, Mildred
TI Predictors of shoulder dystocia with and without neonatal injury using
multivariable modeling
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Burkman, Ronald] Baystate Med Ctr, Springfield, MA USA.
[Gregory, Kimberly] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Hoffman, Matthew] Christiana Care Hlth Syst, Newark, DE USA.
[Bailit, Jennifer L.] Case Western Reserve Univ, Dept OB GYN, Div Maternal Fetal Med, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
[Van Veldhusien, Paul; Liu, Li] EMMES Corp, Rockville, MD USA.
[Branch, Ware] Univ Utah, Salt Lake City, UT USA.
[Branch, Ware] Intermt Healthcare, Salt Lake City, UT USA.
[Haberman, Shoshana] Maimonides Hosp, Brooklyn, NY 11219 USA.
[Landy, Helain] MedStar Hlth Georgetown Univ Hosp, Washington, DC USA.
[Troendle, James; Zhang, Jun] NICHHD, Bethesda, MD 20892 USA.
[Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA.
[Hatjis, Christos] Summa Hlth Syst, Akron, OH USA.
[Wilkins, Isabelle; Kominiarek, Michelle; Hibbard, Judith] Univ Illinois, Chicago, IL USA.
[Gonzalez, Victor] Univ Miami, Miami, FL USA.
[Ramirez, Mildred] Univ Texas Houston, Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 314
BP S129
EP S130
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500313
ER
PT J
AU Carreno, C
AF Carreno, Carlos
TI Excessive early gestational weight gain and risks of gestational
diabetes and large for gestational age infants in nulliparous women
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Carreno, Carlos] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 803
BP S314
EP S314
DI 10.1016/j.ajog.2010.10.825
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500800
ER
PT J
AU Clark, EAS
AF Clark, Erin A. S.
TI Interleukin 6 receptor haplotype and neurodevelopmental delay at age 2
years in a cohort at risk for early preterm birth
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Clark, Erin A. S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 66
BP S38
EP S38
DI 10.1016/j.ajog.2010.10.079
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500067
ER
PT J
AU Conway, D
Parker, A
Carter, M
Dudley, D
Holden, A
AF Conway, Deborah
Parker, Ashley
Carter, Margaret
Dudley, Donald
Holden, Alan
TI Obesity is an independent risk factor for late preterm birth in San
Antonio, Texas
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Conway, Deborah] Eunice Kennedy Shriver NICHD SCRN, San Antonio, TX USA.
[Parker, Ashley; Carter, Margaret; Dudley, Donald; Holden, Alan] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 101
BP S55
EP S55
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500102
ER
PT J
AU Conway, D
AF Conway, Deborah
TI Estimating Gestational age at stillbirth using clinical and pathologic
data: the stillbirth collaborative research network algorithm
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Conway, Deborah] Eunice Kennedy Shriver NICHD SCRN, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 106
BP S56
EP S56
DI 10.1016/j.ajog.2010.10.122
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500106
ER
PT J
AU Costantine, MM
Clark, EAS
AF Costantine, Maged M.
Clark, Erin A. S.
TI Oxidative stress, neuroprotection candidate gene polymorphisms and
adverse neurodevelopmental outcomes
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Costantine, Maged M.; Clark, Erin A. S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, MFMU Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 67
BP S38
EP S38
DI 10.1016/j.ajog.2010.10.080
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500068
ER
PT J
AU Figueroa, D
AF Figueroa, Dana
TI Relationship between the 1-hour glucose loading test results and
perinatal outcomes
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Figueroa, Dana] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 250
BP S107
EP S107
DI 10.1016/j.ajog.2010.10.268
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500249
ER
PT J
AU Graves, SW
Esplin, MS
AF Graves, Steven W.
Esplin, M. Sean
TI Validation of predictive preterm birth biomarkers obtained by maternal
serum proteomics
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Graves, Steven W.; Esplin, M. Sean] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 3
Z9 3
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 80
BP S46
EP S46
DI 10.1016/j.ajog.2010.10.095
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500081
ER
PT J
AU Harper, M
AF Harper, Margaret
TI Omega-3 fatty acids and cytokine production
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 507
BP S202
EP S203
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500505
ER
PT J
AU Harper, M
AF Harper, Margaret
TI Tumor necrosis factor alpha-308 genetic polymorphism and cytokine
production
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 506
BP S202
EP S202
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500504
ER
PT J
AU Harper, M
AF Harper, Margaret
TI Inflammatory cytokines and recurrent preterm birth
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 508
BP S203
EP S203
DI 10.1016/j.ajog.2010.10.527
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500506
ER
PT J
AU Hauth, JC
AF Hauth, John C.
TI Maternal insulin resistance and preeclampsia
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Hauth, John C.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 2
Z9 2
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 19
BP S12
EP S12
DI 10.1016/j.ajog.2010.10.027
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500020
ER
PT J
AU Hauth, JC
AF Hauth, John C.
TI Insulin resistance in pregnancy and maternal body mass
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Hauth, John C.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 5
Z9 5
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 815
BP S318
EP S318
DI 10.1016/j.ajog.2010.10.837
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500812
ER
PT J
AU Hoffman, M
Sciscione, A
Laughon, SK
Zhang, J
Reddy, U
AF Hoffman, Matthew
Sciscione, Anthony
Laughon, S. Katherine
Zhang, Jun
Reddy, Uma
TI The duration of labor induction and maternal and neonatal outcomes
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Hoffman, Matthew] Christiana Care Hlth Syst, Newark, DE USA.
[Sciscione, Anthony] Christiana Hosp, Newark, DE USA.
[Laughon, S. Katherine] Div Epidemiol Stat & Prevent Res, Bethesda, MD USA.
[Zhang, Jun] NICHHD, Bethesda, MD 20892 USA.
[Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 294
BP S122
EP S122
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500293
ER
PT J
AU Johnson, J
AF Johnson, Julie
TI Outcomes associated with failure to achieve the 2009 Institute of
Medicine (IOM) guidelines for weight gain in pregnancy
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Johnson, Julie] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 582
BP S232
EP S232
DI 10.1016/j.ajog.2010.10.602
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500580
ER
PT J
AU Laughon, SK
Zhang, J
Troendle, J
Reddy, U
AF Laughon, S. Katherine
Zhang, Jun
Troendle, James
Reddy, Uma
TI Simplifying the bishop score
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Laughon, S. Katherine] Div Epidemiol Stat & Prevent Res, Bethesda, MD USA.
[Zhang, Jun; Troendle, James] NICHHD, Bethesda, MD 20892 USA.
[Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 319
BP S131
EP S132
DI 10.1016/j.ajog.2010.10.337
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500318
ER
PT J
AU Makhlouf, M
AF Makhlouf, Michel
TI Adverse pregnancy outcomes among women with prior spontaneous or induced
abortions
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Makhlouf, Michel] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 513
BP S204
EP S205
DI 10.1016/j.ajog.2010.10.532
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500511
ER
PT J
AU Peaceman, A
AF Peaceman, Alan
TI Duration of latency after PPROM by gestational age at time of membrane
rupture
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Peaceman, Alan] NICHHD, Maternal Fetal Med Units Network, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 456
BP S183
EP S183
DI 10.1016/j.ajog.2010.10.475
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500455
ER
PT J
AU Rana, S
Karumanchi, A
Wang, A
Powe, C
Ecker, J
Thadhani, R
Levine, R
AF Rana, Sarosh
Karumanchi, Ananth
Wang, Alice
Powe, Camille
Ecker, Jeffery
Thadhani, Ravi
Levine, Richard
TI Preeclampsia is not independently associated with large for gestational
age infants
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Rana, Sarosh; Karumanchi, Ananth] Harvard Univ, Sch Med, BIDMC, Boston, MA USA.
[Wang, Alice] Boston Med Ctr, Boston, MA USA.
[Powe, Camille; Ecker, Jeffery; Thadhani, Ravi] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Levine, Richard] NICHD, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 244
BP S105
EP S105
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500243
ER
PT J
AU Roberson, R
Kuddo, T
Benassou, I
Spong, C
AF Roberson, Robin
Kuddo, Thea
Benassou, Ines
Spong, Catherine
TI Cytokine alterations in fetal alcohol syndrome
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Roberson, Robin; Kuddo, Thea; Benassou, Ines; Spong, Catherine] NICHD, UPDN, DIR, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 453
BP S182
EP S182
DI 10.1016/j.ajog.2010.10.472
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500452
ER
PT J
AU Roberson, R
Kuddo, T
Benassou, I
Abebe, D
Spong, C
AF Roberson, Robin
Kuddo, Thea
Benassou, Ines
Abebe, Daniel
Spong, Catherine
TI Neuroprotective fractalkine in fetal alcohol syndrome
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Roberson, Robin; Kuddo, Thea; Benassou, Ines; Abebe, Daniel; Spong, Catherine] UPDN DIR NICHD NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 53
BP S32
EP S32
DI 10.1016/j.ajog.2010.10.065
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500054
ER
PT J
AU Saade, G
AF Saade, George
CA Eunice Kennedy Shriver NICHD SCRN
TI Risk of stillbirth according to second trimester aneuploidy screen
result in the Stillbirth Collaborative Research Network: a
population-based study
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Eunice Kennedy Shriver NICHD SCRN] NICHD, Bethesda, MD USA.
[Saade, George] Univ Texas Med Branch, Galveston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 62
BP S37
EP S37
DI 10.1016/j.ajog.2010.10.075
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500063
ER
PT J
AU Stuebe, A
AF Stuebe, Alison
TI Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Stuebe, Alison] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 537
BP S215
EP S215
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500535
ER
PT J
AU Stuebe, A
AF Stuebe, Alison
TI Is there a threshold OGTT value for predicting adverse neonatal outcome?
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Stuebe, Alison] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 538
BP S215
EP S215
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500536
ER
PT J
AU VanVeldhuisen, P
Zhang, J
Troendle, J
Beaver, J
Kominiarek, M
Hibbard, J
AF VanVeldhuisen, Paul
Zhang, Jun
Troendle, James
Beaver, Julie
Kominiarek, Michelle
Hibbard, Judith
TI Contemporary labor patterns: the impact of maternal body mass index
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [VanVeldhuisen, Paul] EMMES Corp, Rockville, MD USA.
[Zhang, Jun; Troendle, James; Beaver, Julie] NICHHD, Bethesda, MD 20892 USA.
[Kominiarek, Michelle; Hibbard, Judith] Univ Illinois, Chicago, IL USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 82
BP S47
EP S47
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500083
ER
PT J
AU Varner, M
AF Varner, Michael
TI Umbilical cord homogenate toxicology and serum cotinine levels in
stillbirths and live births
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Varner, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 591
BP S235
EP S236
DI 10.1016/j.ajog.2010.10.611
PG 4
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500589
ER
PT J
AU Varner, M
AF Varner, Michael
TI Influenza-like illness in hospitalized pregnant and immediately
postpartum women during the 2009-2010 H1N1 influenza pandemic
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Meeting Abstract
CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine
CY FEB 01-06, 2010
CL Chicago, IL
SP Soc Maternal Fetal Med
C1 [Varner, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2011
VL 204
SU 1
MA 75
BP S43
EP S43
DI 10.1016/j.ajog.2010.10.089
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 702WV
UT WOS:000285927500076
ER
PT J
AU Baird, DD
Steiner, AZ
AF Baird, Donna Day
Steiner, Anne Z.
TI Anti-mullerian hormone (AMH) and repetitive oocyte donation
SO FERTILITY AND STERILITY
LA English
DT Letter
C1 [Baird, Donna Day] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Steiner, Anne Z.] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA.
RP Baird, DD (reprint author), NIEHS, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
RI Baird, Donna/D-5214-2017
OI Baird, Donna/0000-0002-5544-2653
NR 2
TC 0
Z9 0
U1 3
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD JAN
PY 2011
VL 95
IS 1
BP E5
EP E5
DI 10.1016/j.fertnstert.2010.09.051
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 695ZL
UT WOS:000285411600005
PM 21074151
ER
PT J
AU Kitamura, K
Farber, J
Kelsall, B
AF Kitamura, K.
Farber, J.
Kelsall, B.
TI Possible role for CCR6+regulatory T cell in the T cell-transfer model of
colitis
SO INFLAMMATORY BOWEL DISEASES
LA English
DT Meeting Abstract
CT Advances in Inflammatory Bowel Diseases Crohns and Colitis Foundations
National Clinical and Research Conference
CY DEC 09-12, 2010
CL Hollywood, FL
C1 [Kitamura, K.] Kanazawa Univ, Kanazawa, Ishikawa, Japan.
[Kitamura, K.; Farber, J.; Kelsall, B.] NIAID, LMI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1078-0998
J9 INFLAMM BOWEL DIS
JI Inflamm. Bowel Dis.
PD JAN
PY 2011
VL 17
SU 1
BP S5
EP S5
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 693WO
UT WOS:000285256300018
ER
PT J
AU Meylan, F
Song, Y
Fuss, I
Villarreal, S
Kahle, E
Malm, I
Acharya, K
Ramos, H
Lo, L
Mentink-Kane, M
Wynn, T
Migone, T
Strober, W
Siegel, R
AF Meylan, F.
Song, Y.
Fuss, I
Villarreal, S.
Kahle, E.
Malm, I
Acharya, K.
Ramos, H.
Lo, L.
Mentink-Kane, M.
Wynn, T.
Migone, T.
Strober, W.
Siegel, R.
TI The TNF-family cytokine TL1A drives IL-13-dependent small intestinal
inflammation.
SO INFLAMMATORY BOWEL DISEASES
LA English
DT Meeting Abstract
CT Advances in Inflammatory Bowel Diseases Crohns and Colitis Foundations
National Clinical and Research Conference
CY DEC 09-12, 2010
CL Hollywood, FL
C1 [Meylan, F.; Song, Y.; Villarreal, S.; Kahle, E.; Malm, I; Acharya, K.; Ramos, H.; Siegel, R.] NIAMS, NIH, Bethesda, MD USA.
[Fuss, I; Strober, W.] NIAID, LHD, NIH, Bethesda, MD 20892 USA.
[Lo, L.; Migone, T.] HGS, Rockville, MD USA.
[Mentink-Kane, M.; Wynn, T.] NIAID, LPD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1078-0998
J9 INFLAMM BOWEL DIS
JI Inflamm. Bowel Dis.
PD JAN
PY 2011
VL 17
SU 1
BP S16
EP S16
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 693WO
UT WOS:000285256300050
ER
PT J
AU Best, AM
Chang, JJ
Dull, AB
Beutler, JA
Martinez, ED
AF Best, Anne M.
Chang, Jianjun
Dull, Angie B.
Beutler, John A.
Martinez, Elisabeth D.
TI Identification of Four Potential Epigenetic Modulators from the NCI
Structural Diversity Library Using a Cell-Based Assay
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Article
ID HISTONE DEACETYLASE INHIBITOR; SMALL-MOLECULE INHIBITOR; REFRACTORY
SOLID TUMORS; CANCER; LYMPHOMA; THERAPY; VORINOSTAT; EXPRESSION; ENZYMES
AB Epigenetic pathways help control the expression of genes. In cancer and other diseases, aberrant silencing or overexpression of genes, such as those that control cell growth, can greatly contribute to pathogenesis. Access to these genes by the transcriptional machinery is largely mediated by chemical modifications of DNA or histones, which are controlled by epigenetic enzymes, making these enzymes attractive targets for drug discovery. Here we describe the characterization of a locus derepression assay, a fluorescence-based mammalian cellular system which was used to screen the NCI structural diversity library for novel epigenetic modulators using an automated imaging platform. Four structurally unique compounds were uncovered that, when further investigated, showed distinct activities. These compounds block the viability of lung cancer and melanoma cells, prevent cell cycle progression, and/or inhibit histone deacetylase activity, altering levels of cellular histone acetylation.
C1 [Best, Anne M.; Chang, Jianjun; Martinez, Elisabeth D.] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.
[Best, Anne M.; Chang, Jianjun; Martinez, Elisabeth D.] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA.
[Dull, Angie B.] NCI, Mol Targets Lab, Ctr SAIC Frederick, Frederick, MD 21702 USA.
[Beutler, John A.] NCI, Mol Targets Lab, Ctr Canc Res, Dallas, TX 75390 USA.
RP Martinez, ED (reprint author), Univ Texas SW Med Ctr Dallas, Dept Pharmacol, 6000 Harry Hines Blvd, Dallas, TX 75390 USA.
EM elisabeth.martinez@utsouthwestern.edu
RI Beutler, John/B-1141-2009
OI Beutler, John/0000-0002-4646-1924
FU NCI [P50-CA70907, K22CA118717-01]; Doctors Cancer Foundation; National
Cancer Institute, National Institutes of Health [HHSN26120080001E]; NIH,
National Cancer Institute, Center for Cancer Research
FX The authors are grateful to Drs. Gordon Hager, John Minna, and Jerry
Niederkorn for the generous gift of cell lines. The authors are indebted
to Dr. George E. Rottinghaus for the kind gift of secalonic acid D and
to Dr. David Schump for providing depsipeptide. This study was partly
supported by the NCI (through a career development Award under
P50-CA70907, University of Texas SPORE in Lung Cancer to E.D. Martinez,
and through K22CA118717-01 Grant to E.D. Martinez) and by the Doctors
Cancer Foundation (Nolan Miller Lung Cancer grant to E.D. Martinez).
This project has been funded in whole or in part with federal funds from
the National Cancer Institute, National Institutes of Health, under
Contract no. HHSN26120080001E. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the U.S. Government.
This Research was supported in part by the Intramural Research Program
of the NIH, National Cancer Institute, Center for Cancer Research.
NR 35
TC 9
Z9 9
U1 1
U2 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 868095
DI 10.1155/2011/868095
PG 11
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 706WI
UT WOS:000286248100001
ER
PT J
AU Smith, HA
Maricque, BB
Eberhardt, J
Petersen, B
Gulley, JL
Schlom, J
McNeel, DG
AF Smith, Heath A.
Maricque, Brett B.
Eberhardt, John
Petersen, Benjamin
Gulley, James L.
Schlom, Jeffrey
McNeel, Douglas G.
TI IgG Responses to Tissue-Associated Antigens as Biomarkers of
Immunological Treatment Efficacy
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Article
ID PROSTATE-CANCER PATIENTS; IMMUNE-RESPONSES; TESTIS ANTIGEN; VACCINE;
IDENTIFICATION; BLOCKADE; PSA
AB We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n = 34), a poxviral vaccine (n = 31), and a DNA vaccine (n = 21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN). We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.
C1 [Smith, Heath A.; Maricque, Brett B.; McNeel, Douglas G.] Univ Wisconsin, Carbone Comprehens Canc Ctr, Madison, WI 53705 USA.
[Eberhardt, John; Petersen, Benjamin] DecisionQ Corp, Washington, DC 20007 USA.
[Gulley, James L.; Schlom, Jeffrey] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[McNeel, Douglas G.] 7007 Wisconsin Inst Med Res, Madison, WI 53705 USA.
RP McNeel, DG (reprint author), Univ Wisconsin, Carbone Comprehens Canc Ctr, 1111 Highland Ave, Madison, WI 53705 USA.
EM dm3@medicine.wisc.edu
RI Gulley, James/K-4139-2016
OI Gulley, James/0000-0002-6569-2912
FU NIH [K23 RR16489]; US Army Medical Research and Materiel Command
[W81XWH-06-1-0184]
FX This work was supported by NIH (K23 RR16489), and by the US Army Medical
Research and Materiel Command Prostate Cancer Research program
(W81XWH-06-1-0184).
NR 23
TC 6
Z9 6
U1 0
U2 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1110-7243
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 454861
DI 10.1155/2011/454861
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 706RX
UT WOS:000286236600001
ER
PT S
AU You, D
Antani, S
Demner-Fushman, D
Govindaraju, V
Thoma, GR
AF You, Daekeun
Antani, Sameer
Demner-Fushman, Dina
Govindaraju, Venu
Thoma, George R.
GP IEEE
TI Detecting Figure-panel Labels in Medical Journal Articles using MRF
SO 11TH INTERNATIONAL CONFERENCE ON DOCUMENT ANALYSIS AND RECOGNITION
(ICDAR 2011)
SE Proceedings of the International Conference on Document Analysis and
Recognition
LA English
DT Proceedings Paper
CT 11th International Conference on Document Analysis and Recognition
(ICDAR)
CY SEP 18-21, 2011
CL Beijing, PEOPLES R CHINA
SP Chinese Acad Sci, FOUNDER, NSFC, FUJITSU, Hanvon Technol, Green Apple Data Ctr, ABBYY, Raytheon BBN Technologies, Nuance, A2iA, ITESOFT, Int Assoc Pattern Recognit, TC10 Graph Recognit & TC11 Reading Syst, CAA, Tsinghua Univ, CASIA, HITACHI
DE image-text detection; Markov Random Field; belief propagation; OCR;
Neural network; image binarization; CBIR; image classification
AB We present a method for figure-panel (subfigure) label detection and recognition in multi-panel figures extracted from biomedical articles. Figures in biomedical articles often comprise several subfigures that are identified by superimposed panel labels (`A', `B', ...) which are referenced in the figure caption and discussion in the article body. Splitting such multi-panel figures into individual subfigures is a necessary step for improved multimodal biomedical information retrieval. Prior to feature extraction for indexing and retrieval of biomedical figures it is necessary to classify image content in each subfigure by its modality (X-ray, MRI, CT, etc.) and other relevant criteria. Subfigure labels are valuable in associating individual panels with relevant text in captions and discussion. We propose a 4-step panel label detection method based on Markov Random Field (MRF). Experiments on 515 multi-panel figures and analysis of the results show promising results. We present the successes and identify critical challenges.
C1 [You, Daekeun; Govindaraju, Venu] SUNY Buffalo, Ctr Unified Biometr & Sensors, Dept Comp Sci & Engn, Buffalo, NY 14260 USA.
[Antani, Sameer; Demner-Fushman, Dina; Thoma, George R.] NIH, Natl Lib Medicine, Bethesda, MD 20894 USA.
RP You, D (reprint author), SUNY Buffalo, Ctr Unified Biometr & Sensors, Dept Comp Sci & Engn, Buffalo, NY 14260 USA.
EM dyou@buffalo.edu; santani@mail.nih.gov; ddemner@mail.nih.gov;
govind@buffalo.edu; gthoma@mail.nih.gov
OI Antani, Sameer/0000-0002-0040-1387
FU Intramural Research Program of the National Institutes of Health (NIH);
National Library of Medicine (NLM); Lister Hill National Center for
Biomedical Communications (LHNCBC)
FX This research is supported by the Intramural Research Program of the
National Institutes of Health (NIH), National Library of Medicine (NLM),
and Lister Hill National Center for Biomedical Communications (LHNCBC).
We would like to thank the CLEF [8] organizers for making the database
available for the experiments.
NR 9
TC 1
Z9 1
U1 0
U2 0
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA
SN 1520-5363
BN 978-0-7695-4520-2
J9 PROC INT CONF DOC
PY 2011
BP 967
EP 971
DI 10.1109/ICDAR.2011.196
PG 5
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
Electronic
SC Computer Science; Engineering
GA BB4XG
UT WOS:000343450700190
ER
PT S
AU Bourbakis, N
Makrogiannis, S
Kapogiannis, D
AF Bourbakis, N.
Makrogiannis, S.
Kapogiannis, D.
GP IEEE
TI A Synergistic Model for Monitoring Brain's Changes: A Case Study
SO 2011 23RD IEEE INTERNATIONAL CONFERENCE ON TOOLS WITH ARTIFICIAL
INTELLIGENCE (ICTAI 2011)
SE Proceedings-International Conference on Tools With Artificial
Intelligence
LA English
DT Proceedings Paper
CT 23rd IEEE International Conference on Tools with Artificial Intelligence
(ICTAI)
CY NOV 07-09, 2011
CL Boca Raton, FL
SP IEEE, IEEE Comp Soc, IEEE Comp Soc Tech Comm Multimedia Comp (TCMC), Bio & Artificial Intelligence Soc (BAIS), Florida Atlant Univ (FAU), Univ Technol, Ctr Quantum Comp & Intelligent Syst (UTS-QCIS), Tsinghua Univ, Arnetminer
ID IMAGES
AB It is known that the early detection of chronic diseases significantly increases the life span of the elderly and improves the quality of life in general. Since the brain is the most valuable part of the human body, it is very important for the physicians to know the stages of aging and changes that take place during these stages and possible implications associated with them in order to more effectively treat their patients. In addition, fMRI provides information (size, density, location, etc) from brain images for the active regions during thinking and/or performing certain tasks. Thus, in this paper a monitoring brain-aging model based on a synergy of methodologies, like image segmentation, registration, local global (L-G) graphs and stochastic Petri net (SPN) graphs is presented. In particular, the synergistic brain-aging model uses fMRI images to detect, extract and associate the way that the brain regions interact regarding thinking and/or executing certain tasks. These brain-region images are extracted and geometrically are represented and associated with the L-G graphs. Then the use of SPN graphs models the regions' functionality. Thus, comparing the L-G and SPN graphs extracted from fMRI images taken in different periods from the same subject, the model has the capability to detect changes and associate them in order the medical expert to monitor the health status and provide a diagnosis or prognosis regarding a human subject. Sets of L-G and SPN graph models generated in time for each particular subject are available in an L-G/SPN graph Database. Here the synergistic model and its proof of concept are presented.
C1 [Bourbakis, N.] Wright State Univ, ATR Ctr, Dayton, OH 45435 USA.
[Bourbakis, N.] AIIS Inc, Centerville, Ohio.
[Makrogiannis, S.; Kapogiannis, D.] NIA, Baltimore, MD 21218 USA.
RP Bourbakis, N (reprint author), Wright State Univ, ATR Ctr, Dayton, OH 45435 USA.
NR 8
TC 0
Z9 0
U1 0
U2 2
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA
SN 1082-3409
BN 978-0-7695-4596-7
J9 PROC INT C TOOLS ART
PY 2011
BP 1093
EP 1098
DI 10.1109/ICTAI.2011.186
PG 6
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
Electronic
SC Computer Science; Engineering
GA BYJ28
UT WOS:000299009900179
ER
PT S
AU Nandy, K
Gudla, PR
Amundsen, R
Meaburn, KJ
Misteli, T
Lockett, SJ
AF Nandy, Kaustav
Gudla, Prabhakar R.
Amundsen, Ryan
Meaburn, Karen J.
Misteli, Tom
Lockett, Stephen J.
GP IEEE
TI Supervised Learning Framework For Screening Nuclei in Tissue Sections
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID AUTOMATIC SEGMENTATION; IMAGES
AB Accurate segmentation of cell nuclei in microscope images of tissue sections is a key step in a number of biological and clinical applications. Often such applications require analysis of large image datasets for which manual segmentation becomes subjective and time consuming. Hence automation of the segmentation steps using fast, robust and accurate image analysis and pattern classification techniques is necessary for high throughput processing of such datasets. We describe a supervised learning framework, based on artificial neural networks (ANNs), to identify well-segmented nuclei in tissue sections from a multistage watershed segmentation algorithm. The successful automation was demonstrated by screening over 1400 well segmented nuclei from 9 datasets of human breast tissue section images and comparing the results to a previously used stacked classifier based analysis framework.
C1 [Nandy, Kaustav; Gudla, Prabhakar R.; Lockett, Stephen J.] NCI Frederick, Opt Microscopy & Anal Lab, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA.
RP Nandy, K (reprint author), NCI Frederick, Opt Microscopy & Anal Lab, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA.
EM nandyk@mail.nih.gov; gudlap@mail.nih.gov; ryan.j.amundsen@gmail.com;
meaburnk@mail.nih.gov; mistelit@mail.nih.gov; locketts@mail.nih.gov
OI Meaburn, Karen/0000-0002-1327-5957
NR 15
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 5989
EP 5992
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810004227
ER
PT S
AU Caban, JJ
Yao, JH
Bagci, U
Mollura, DJ
AF Caban, Jesus J.
Yao, Jianhua
Bagci, Ulas
Mollura, Daniel J.
GP IEEE
TI Monitoring Pulmonary Fibrosis by Fusing Clinical, Physiological, and
Computed Tomography Features
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
AB Advances in medical imaging and screening tests have made possible the detection and diagnosis of many diseases in their early stages. Those advances have enabled more effective planning, execution, and monitoring of a treatment plan. However, early detection has also resulted in an increase of the number of longitudinal radiographs requested for most patients, thus increasing the risk for potential long-term effects of ionizing radiation exposure and increasing the cost associated with a specific treatment plan. The aim of this paper is to study the associations between clinical measurements and quantitative image features in patients with pulmonary fibrosis. The association between these multi-modal features could be used to more accurately determine the state of the disease and could potentially be used to predict many of the longitudinal image features when CT images are not available. Our results show how textural image features are highly correlated with the severity of fibrosis, how clinical variables can be combined to monitor progression, and how simple blood features can be used to predict statistical image attributes of the lungs.
C1 [Caban, Jesus J.] NIH, Natl Lib Med, Bethesda, MD 20894 USA.
RP Caban, JJ (reprint author), NIH, Natl Lib Med, Bethesda, MD 20894 USA.
EM jesus.caban@nih.gov
OI Bagci, Ulas/0000-0001-7379-6829
NR 9
TC 3
Z9 3
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 6216
EP 6219
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810004282
ER
PT S
AU Bagci, U
Yao, JH
Caban, J
Turkbey, E
Aras, O
Mollura, DJ
AF Bagci, Ulas
Yao, Jianhua
Caban, Jesus
Turkbey, Evrim
Aras, Omer
Mollura, Daniel J.
GP IEEE
TI A Graph-Theoretic Approach for Segmentation of PET Images
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID VOLUME
AB Segmentation of positron emission tomography (PET) images is an important objective because accurate measurement of signal from radio-tracer activity in a region of interest is critical for disease treatment and diagnosis. In this study, we present the use of a graph based method for providing robust, accurate, and reliable segmentation of functional volumes on PET images from standardized uptake values (SUVs). We validated the success of the segmentation method on different PET phantoms including ground truth CT simulation, and compared it to two well-known threshold based segmentation methods. Furthermore, we assessed intra- and inter-observer variation in delineation accuracy as well as reproducibility of delineations using real clinical data. Experimental results indicate that the presented segmentation method is superior to the commonly used threshold based methods in terms of accuracy, robustness, repeatability, and computational efficiency.
C1 [Bagci, Ulas; Mollura, Daniel J.] NIH, Ctr Infect Dis Imaging, Bethesda, MD 20892 USA.
[Bagci, Ulas; Yao, Jianhua; Turkbey, Evrim; Aras, Omer; Mollura, Daniel J.] NIH, Dept Radiol & Imag Sci, Bethesda, MD 20892 USA.
[Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
[Aras, Omer] Univ Maryland Med Syst, Dept Radiol Nucl Med, Baltimore, MD USA.
RP Bagci, U (reprint author), NIH, Ctr Infect Dis Imaging, Bethesda, MD 20892 USA.
EM ulas.bagci@nih.gov
OI Bagci, Ulas/0000-0001-7379-6829
NR 11
TC 16
Z9 16
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 8479
EP 8482
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810006150
ER
PT S
AU Kim, J
Park, HS
Damiano, DL
AF Kim, Jonghyun
Park, Hyung-Soon
Damiano, Diane L.
GP IEEE
TI Accuracy and Reliability of Haptic Spasticity Assessment Using HESS
(Haptic Elbow Spasticity Simulator)
SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE
AND BIOLOGY SOCIETY (EMBC)
SE IEEE Engineering in Medicine and Biology Society Conference Proceedings
LA English
DT Proceedings Paper
CT 33rd Annual International Conference of the IEEE
Engineering-in-Medicine-and-Biology-Society (EMBS)
CY AUG 30-SEP 03, 2011
CL Boston, MA
SP IEEE, Engn Med & Biol Soc (EMBS)
ID MODIFIED ASHWORTH SCALE; MODIFIED TARDIEU SCALE; SEVERE BRAIN-INJURY;
INTERRATER RELIABILITY; CEREBRAL-PALSY; CHILDREN
AB Clinical assessment of spasticity tends to be subjective because of the nature of the in-person assessment; severity of spasticity is judged based on the muscle tone felt by a clinician during manual manipulation of a patient's limb. As an attempt to standardize the clinical assessment of spasticity, we developed HESS (Haptic Elbow Spasticity Simulator), a programmable robotic system that can provide accurate and consistent haptic responses of spasticity and thus can be used as a training tool for clinicians. The aim of this study is to evaluate the accuracy and reliability of the recreated haptic responses. Based on clinical data collected from children with cerebral palsy, four levels of elbow spasticity (1, 1+, 2, and 3 in the Modified Ashworth Scale [MAS]) were recreated by HESS. Seven experienced clinicians manipulated HESS to score the recreated haptic responses. The accuracy of the recreation was assessed by the percent agreement between intended and determined MAS scores. The inter-rater reliability among the clinicians was analyzed by using Fleiss's kappa. In addition, the level of realism with the recreation was evaluated by a questionnaire on "how realistic" this felt in a qualitative way. The percent agreement was high (85.7 +/- 11.7%), and for inter-rater reliability, there was substantial agreement (kappa=0.646) among the seven clinicians. The level of realism was 7.71 +/- 0.95 out of 10. These results show that the haptic recreation of spasticity by HESS has the potential to be used as a training tool for standardizing and enhancing reliability of clinical assessment.
C1 [Kim, Jonghyun; Park, Hyung-Soon; Damiano, Diane L.] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA.
EM parkhs@cc.nih.gov
RI Damiano, Diane/B-3338-2010
OI Damiano, Diane/0000-0002-2770-5356
NR 18
TC 2
Z9 2
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1557-170X
BN 978-1-4244-4122-8
J9 IEEE ENG MED BIO
PY 2011
BP 8527
EP 8530
PG 4
WC Engineering, Biomedical; Engineering, Electrical & Electronic
SC Engineering
GA BYH52
UT WOS:000298810006162
ER
PT S
AU Chen, Y
Wierwille, J
Roney, CA
Xu, BY
Griffiths, GL
Summers, RM
AF Chen, Yu
Wierwille, Jeremiah
Roney, Celeste A.
Xu, Biying
Griffiths, Gary L.
Summers, Ronald M.
GP IEEE
TI Combined OCT and Fluorescence Imaging for Cancer Detection and
Therapeutic Monitoring
SO 2011 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
SE Conference on Lasers and Electro-Optics
LA English
DT Proceedings Paper
CT Conference on Lasers and Electro-Optics (CLEO)
CY MAY 01-06, 2011
CL Baltimore, MD
ID OPTICAL COHERENCE TOMOGRAPHY
AB We developed a co-registered optical coherence tomography (OCT) and fluorescence molecular imaging (FMI) system for simultaneous morphological and molecular imaging. This system enables real-time imaging of fluorescence-labeled gold nanoparticles and monitoring photothermal therapy. (C) 2011 Optical Society of America
C1 [Chen, Yu; Wierwille, Jeremiah] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
[Roney, Celeste A.; Summers, Ronald M.] NIH, Dept Radiol & Imaging Sci, Clin Sci, Bethesda, MD 20892 USA.
[Xu, Biying; Griffiths, Gary L.] NIH, Natl Heart Lung & Blood Inst, Imaging Probe Dev Ctr, Bethesda, MD 20892 USA.
RP Chen, Y (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
EM yuchen@umd.edu
NR 5
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2160-9020
BN 978-1-55752-910-7
J9 CONF LASER ELECTR
PY 2011
PG 2
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BXB77
UT WOS:000295612402237
ER
PT S
AU Park, HS
Kim, J
Damiano, DL
AF Park, Hyung-Soon
Kim, Jonghyun
Damiano, Diane L.
GP IEEE
TI Haptic Recreation of Elbow Spasticity
SO 2011 IEEE INTERNATIONAL CONFERENCE ON REHABILITATION ROBOTICS (ICORR)
SE International Conference on Rehabilitation Robotics ICORR
LA English
DT Proceedings Paper
CT IEEE International Conference on Rehabilitation Robotics
(ICORR)/International Neurorehabilitation Symposium (INRS)/International
Conference on Virtual Rehabilitation (ICVR)
CY JUN 27-JUL 01, 2011
CL ETH Zurich, Zurich, SWITZERLAND
SP IEEE, RA, EMB, Hocoma, You Rehab, Int Soc Virtual Rehabil (ISVR), Zentrum Ambulante Rehabil, MUNDUS, RITZ
HO ETH Zurich
DE Elbow spasticity; Haptic device; Modified Ashworth Scale
ID CEREBRAL-PALSY; ASHWORTH SCALE; CHILDREN; PATHOPHYSIOLOGY; RELIABILITY
AB The aim of this paper is to develop a haptic device capable of presenting standardized recreation of elbow spasticity. Using the haptic device, clinicians will be able to repeatedly practice the assessment of spasticity without requiring patient involvement, and these practice opportunities will help improve accuracy and reliability of the assessment itself. Haptic elbow spasticity simulator (HESS) was designed and prototyped according to mechanical requirements to recreate the feel of elbow spasticity. Based on the data collected from subjects with elbow spasticity, a mathematical model representing elbow spasticity is proposed. As an attempt to differentiate the feel of each score in Modified Ashworth Scale (MAS), parameters of the model were obtained respectively for three different MAS scores 1, 1+, and 2. The implemented haptic recreation was evaluated by experienced clinicians who were asked to give MAS scores by manipulating the haptic device. The clinicians who participated in the study were blinded to each other's scores and to the given models. They distinguished the three models and the MAS scores given to the recreated models matched 100% with the original MAS scores from the patients.
C1 [Park, Hyung-Soon; Kim, Jonghyun; Damiano, Diane L.] NIH, Dept Rehabil Med, Ctr Clin, Funct & Appl Biomech Sect, Bethesda, MD 20892 USA.
RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Funct & Appl Biomech Sect, Bethesda, MD 20892 USA.
EM parkhs@cc.nih.gov
RI Damiano, Diane/B-3338-2010
OI Damiano, Diane/0000-0002-2770-5356
NR 20
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1945-7898
BN 978-1-4244-9862-8
J9 INT C REHAB ROBOT
PY 2011
PG 6
WC Robotics; Rehabilitation
SC Robotics; Rehabilitation
GA BYK51
UT WOS:000299169800124
ER
PT S
AU Khwaja, AM
Daruwalla, P
Manseta, K
Sultan, E
Zhou, L
Pourrezaei, K
Najafizadeh, L
Gandjbakhche, A
Daryoush, AS
AF Khwaja, A. M.
Daruwalla, P.
Manseta, K.
Sultan, E.
Zhou, L.
Pourrezaei, K.
Najafizadeh, L.
Gandjbakhche, A.
Daryoush, A. S.
GP IEEE
TI UWB Wireless Link Design and Implementation Challenges in Broadband
Frequency Modulated fNIR Biomedical Imaging
SO 2011 IEEE RADIO AND WIRELESS SYMPOSIUM (RWS)
SE IEEE Radio and Wireless Symposium
LA English
DT Proceedings Paper
CT IEEE Radio and Wireless Symposium (RWS)
CY JAN 16-19, 2011
CL Phoenix, AR
SP IEEE, IEEE Commun Soc (ComSoc), IEEE Microwave Theory & Tech Soc (MTT-S), IEEE Antennas & Propagat Soc (APS), IEEE Vehicle Tech Soc (VTS)
DE Functional Near Infra Red Imaging (fNIR); Ultra Wide Band
Communications; System Architectures; Gilbert Cell Mixer; Fractal
Antenna
AB Functional spectroscopic measurements of brain matter using near IR wavelengths are characterized by absorption coefficient mu(a) and scattering coefficient mu'(s). To increase the accuracy of parameter extraction, a broadband frequency modulated system is proposed and design and implementation challenges of a completely untethered and field deployable unit and a high speed wireless communication system is considered to complement a free space optical communication system.
C1 [Khwaja, A. M.; Daruwalla, P.; Manseta, K.; Sultan, E.; Zhou, L.; Daryoush, A. S.] Drexel Univ, Dept ECE, Philadelphia, PA 19104 USA.
[Pourrezaei, K.] Drexel Univ, Sch Biomed Engn & Hlth Syst, Philadelphia, PA 19104 USA.
[Najafizadeh, L.; Gandjbakhche, A.] NIH, Bethesda, MD 20892 USA.
RP Khwaja, AM (reprint author), Drexel Univ, Dept ECE, Philadelphia, PA 19104 USA.
EM daryoush@ece.drexel.edu
FU Center for Neuroscience and Regenerative Medicine (CNRM); Intramural
Research Program (IRP); National Institute of Child Health and Human
Development (NICHD)
FX This research is partly supported by the Center for Neuroscience and
Regenerative Medicine (CNRM), and the Intramural Research Program (IRP)
of Eunice Shriver National Institute of Child Health and Human
Development (NICHD) of the National Institutes of Health. We also thank
Prathaban Mookiah from Drexel Wireless Systems Laboratory for assisting
us with antenna radiation pattern measurement.
NR 9
TC 1
Z9 1
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2164-2958
BN 978-1-4244-7685-5
J9 IEEE RADIO WIRELESS
PY 2011
BP 394
EP 397
DI 10.1109/RWS.2011.5725495
PG 4
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYM97
UT WOS:000299393600095
ER
PT S
AU Xia, T
Kapoor, A
Kazanzides, P
Taylor, R
AF Xia, Tian
Kapoor, Ankur
Kazanzides, Peter
Taylor, Russell
GP IEEE
TI A Constrained Optimization Approach to Virtual Fixtures for Multi-Robot
Collaborative Teleoperation
SO 2011 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
SE IEEE International Conference on Intelligent Robots and Systems
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
CY SEP 25-30, 2011
CL San Francisco, CA
SP IEEE, Robot Soc Japan (RSJ), BOSCH, HONDA, KUKA, SRI Int, ABB, Willow Garage, ALDEBARAN, Google, INTUITIVE Surg, SCHUNK, IEEE Ind Elect Soc (IES), Soc Instrument & Control Engineers (SICE), New Technol Fdn (NTF), IEEE Robot & Automat Soc (RAS), Inst Control, Robto & Syst (ICROS)
AB This paper presents a constrained optimization framework that enables the implementation of multi-robot constraints, as virtual fixtures, to assist human operators, in a teleoperated scenario. The collaborative constraints guide the motion of multiple robots such that the spatial and temporal relationships are maintained between them, while following human input motion objectives. We demonstrate this control architecture for the task of manipulating a surgical knot to a target point. The teleoperation system uses four arms from a da Vinci Surgical System (R) (two master manipulators and two slave manipulators), with custom electronics and software. It extends previous work, which focused on a cooperatively controlled system where the motions of two robots were directly controlled by user-applied forces. Our current system enables us to effectively evaluate the accuracy of the knot positioning task and completion time in a clinically realistic setup for Minimally Invasive Surgery.
C1 [Xia, Tian; Kazanzides, Peter; Taylor, Russell] Johns Hopkins Univ, Dept Comp Sci, Lab Computat Sensing & Robot, Baltimore, MD 21218 USA.
[Kapoor, Ankur] Natl Inst Hlth, Bethesda, MD USA.
RP Xia, T (reprint author), Johns Hopkins Univ, Dept Comp Sci, Lab Computat Sensing & Robot, Baltimore, MD 21218 USA.
EM txial@jhu.edu
RI Kazanzides, Peter/A-3358-2010;
OI Kazanzides, Peter/0000-0002-6117-5467
FU National Science Foundation Graduate Research Fellowship
FX he authors gratefully acknowledge Balazs Vagvolgyi and Jim Gwilliam for
assistance with robotic calibration and visualization, and MinYang Jung
and Anton Deguet for assistance with network communication and cisst
library. The funding of this research was provided by the National
Science Foundation Graduate Research Fellowship.
NR 11
TC 6
Z9 6
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2153-0858
BN 978-1-61284-455-8
J9 IEEE INT C INT ROBOT
PY 2011
BP 639
EP 644
PG 6
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems; Engineering, Electrical & Electronic; Robotics
SC Computer Science; Engineering; Robotics
GA BXX70
UT WOS:000297477500100
ER
PT J
AU Cheng, RD
Senseney, J
Pandya, N
McCreedy, E
McAuliffe, MJ
Bokinsky, A
AF Cheng, Ruida
Senseney, Justin
Pandya, Nishith
McCreedy, Evan
McAuliffe, Matthew J.
Bokinsky, Alexandra
BE Soda, P
Tortorella, F
TI A flexible Java GPU-enhanced visualization framework and its
applications
SO 2012 25TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS
(CBMS)
LA English
DT Proceedings Paper
CT 25th International Symposium on Computer-Based Medical Systems (CBMS)
CY JUN 20-22, 2012
CL Univ Campus Bio-Medico Rome, Rome, ITALY
SP IEEE, IEEE Comp Soc, Gruppo Italiano Ricercatori Pattern Recognit, EMB, IFIP, Univ degli Studi Cassino Lazio Meridionale
HO Univ Campus Bio-Medico Rome
AB A flexible biomedical visualization framework implemented with Java, OpenGL, and OpenCL performs efficient volume rendering with large, multi-modal datasets. The,framework takes advantage of the parallel processing power on modern graphics hardware with novel Open CL and GLSL shading language implementations. The Java and GPU environment provide portable advanced biomedical image visualization applications. Several applications built on top of the GPU framework are also presented to show the extensibility of the application. These include multi-surface rendering, stereoscopic rendering, image fusion, and diffusion tensor visualization.
C1 [Cheng, Ruida; Senseney, Justin; Pandya, Nishith; McCreedy, Evan; McAuliffe, Matthew J.] Natl Inst Hlth, Imaging Sci Lab, Ctr Informat Technol, Bethesda, MD 20892 USA.
[Bokinsky, Alexandra] Geometr Tools Inc, Chapel Hill, NC USA.
RP Cheng, RD (reprint author), Natl Inst Hlth, Imaging Sci Lab, Ctr Informat Technol, Bethesda, MD 20892 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-2051-1
PY 2011
PG 6
WC Computer Science, Interdisciplinary Applications; Engineering,
Electrical & Electronic; Radiology, Nuclear Medicine & Medical Imaging
SC Computer Science; Engineering; Radiology, Nuclear Medicine & Medical
Imaging
GA BDA86
UT WOS:000312384400010
ER
PT J
AU Resnik, DB
Shamoo, AE
AF Resnik, David B.
Shamoo, Adil E.
TI The Singapore Statement on Research Integrity
SO ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE
LA English
DT Article
DE Singapore Statement; research integrity; ethics; international research
C1 [Resnik, David B.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Shamoo, Adil E.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
RP Resnik, DB (reprint author), NIEHS, NIH, Box 12233,MD CU 03, Res Triangle Pk, NC 27709 USA.
EM resnikd@niehs.nih.gov
FU National Institute of Environmental Health Sciences (NIEHS), National
Institutes of Health (NIH)
FX This research was supported by the National Institute of Environmental
Health Sciences (NIEHS), National Institutes of Health (NIH). It does
not represent the views of the NIEHS, NIH, or U.S. government.
NR 7
TC 10
Z9 10
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0898-9621
J9 ACCOUNT RES
JI Account. Res.
PY 2011
VL 18
IS 2
BP 71
EP 75
AR PII 934341751
DI 10.1080/08989621.2011.557296
PG 5
WC Medical Ethics
SC Medical Ethics
GA 733JN
UT WOS:000288259100001
PM 21390871
ER
PT J
AU Resnik, DB
AF Resnik, David B.
TI Disclosure of Individualized Research Results: A Precautionary Approach
SO ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE
LA English
DT Article
DE autonomy; beneficence; disclosing research results; precautionary
principle; risk
ID CLINICAL-RESEARCH; THERAPEUTIC MISCONCEPTION; PARTICIPATORY RESEARCH;
PRINCIPLE; SCIENCES; ETHICS; TRIALS; CANCER; SAFE
AB Assessing and managing risks to participants is a central point of contention in the debate about disclosing individualized research results. Those who favor disclosure of only clinically significant results think that disclosing clinically insignificant results is risky and costly, and that harm prevention should take precedence over other ethical considerations. Those who favor giving participants the option of full disclosure regard these risks as insubstantial, and think that obligations to benefit participants and promote their autonomy and right to know outweigh the obligation to prevent harm or financial considerations. The risks of disclosing clinically insignificant research results are currently not quantifiable, due to lack of empirical data. The precautionary principle provides some insight into this debate because it applies to decision-making concerning risks that are plausible but not quantifiable. A precautionary approach would favor full disclosure of individualized results with appropriate safeguards to prevent, minimize, or mitigate risks to participants, such as: validating testing methods; informing participants about their options for receiving tests results and the potential benefits and risks related to receiving results; assessing participants' comfort with handling uncertainty; providing counseling and advice to participants; following-up with individuals who receive tests results; and forming community advisory boards to help investigators deal with issues related to disclosure.
C1 NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
RP Resnik, DB (reprint author), NIEHS, NIH, Box 12233,Mail Drop CU 03, Res Triangle Pk, NC 27709 USA.
EM resnikd@niehs.nih.gov
FU Intramural NIH HHS [ZIA ES102646-04, ZIA ES102646-03]
NR 51
TC 3
Z9 3
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0898-9621
J9 ACCOUNT RES
JI Account. Res.
PY 2011
VL 18
IS 6
BP 382
EP 397
DI 10.1080/08989621.2011.622172
PG 16
WC Medical Ethics
SC Medical Ethics
GA 856NE
UT WOS:000297648300002
PM 22011068
ER
PT J
AU Tang, J
Maddali, K
Dreis, CD
Sham, YY
Vince, R
Pommier, Y
Wang, ZQ
AF Tang, Jing
Maddali, Kasthuraiah
Dreis, Christine D.
Sham, Yuk Y.
Vince, Robert
Pommier, Yves
Wang, Zhengqiang
TI N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV
Reverse Transcriptase and Integrase
SO ACS MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE HIV; integrase; reverse transcriptase; dual inhibitor; rational design
ID IMMUNODEFICIENCY-VIRUS TYPE-1; DESIGNED MULTIPLE LIGANDS; NONNUCLEOSIDE
INHIBITORS; ANTI-HIV-1 ACTIVITY; IN-VITRO; ANALOGS; POTENT; RESISTANCE;
DISCOVERY; EMIVIRINE
AB A new molecular scaffold featuring an N-hydroxyimide functionality and capable of inhibiting both reverse transcriptase (RT) and integrase (IN) of human immunodeficiency virus (HIV) was rationally designed based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) non-nucleoside RT inhibitors (NNRTIs). The design involves a minimal 3-N hydroxylation of the pyrimidine ring of HEPT compound to yield a chelating triad which, along with the existing benzyl group, appeared to satisfy major structural requirements for IN binding. In the mean time, this chemical modification did not severely compromise the compound's ability to inhibit RT. A preliminary structure-activity relationship (SAR) study reveals that this N-3 OH is essential for IN inhibition and that the benzyl group on N-1 side chain is more important for IN binding than the one on C-6.
C1 [Tang, Jing; Dreis, Christine D.; Sham, Yuk Y.; Vince, Robert; Wang, Zhengqiang] Univ Minnesota, Ctr Drug Design, Acad Hlth Ctr, Minneapolis, MN 55455 USA.
[Maddali, Kasthuraiah; Pommier, Yves] NCI, Mol Pharmacol Lab, NIH, Bethesda, MD 20892 USA.
RP Wang, ZQ (reprint author), Univ Minnesota, Ctr Drug Design, Acad Hlth Ctr, 516 Delaware St SE, Minneapolis, MN 55455 USA.
EM wangx472@umn.edu
RI Sham, Yuk/A-6472-2011
FU Center for Drug Design at the University of Minnesota; Center for Cancer
Research, National Cancer Institute; IATAP; NIH
FX This research was supported by the Center for Drug Design at the
University of Minnesota, the Center for Cancer Research, National Cancer
Institute and an IATAP grant to Y.P., NIH.
NR 27
TC 30
Z9 33
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-5875
J9 ACS MED CHEM LETT
JI ACS Med. Chem. Lett.
PD JAN
PY 2011
VL 2
IS 1
BP 63
EP 67
DI 10.1021/ml1002162
PG 5
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 707SL
UT WOS:000286306200013
PM 21499541
ER
PT J
AU Gage, JC
Ghosh, A
Borgonovo, S
Follansbee, S
Wentzensen, N
Gravitt, PE
Grabe, N
Lahrmann, B
Castle, PE
AF Gage, Julia C.
Ghosh, Arpita
Borgonovo, Sylvia
Follansbee, Stephen
Wentzensen, Nicolas
Gravitt, Patti E.
Grabe, Niels
Lahrmann, Bernd
Castle, Philip E.
TI A Comparison of Dacron versus Flocked Nylon Swabs for Anal Cytology
Specimen Collection
SO ACTA CYTOLOGICA
LA English
DT Article
DE Cytology; Anal neoplasia; Human papillomavirus testing; Screening;
Cytological techniques
ID HUMAN-PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA; PCR; MEN; SAMPLES;
LESIONS
AB Objectives: We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology. Study Design: From 23 HIV-positive men screened at Kaiser Permanente San Francisco (San Francisco, Calif., USA), 2 anal specimens were collected, 1 with each swab in random order, and placed into liquid cytology medium. Specimens were tested for cellularity by quantifying a genomic DNA (erv-3). The number of cells was assessed from prepared slides by automated image analysis. Performance was compared between swabs using 2-sample t tests and standard crossover trial analysis methods accounting for period effect. Results: Flocked swabs collected slightly more erv-3 cells than Dacron for the first sample although not significantly (p = 0.18) and a similar number of erv-3 cells for the second sample (p = 0.85). Flocked swabs collected slightly more cells per slide than the Dacron swabs at both time periods although this was only significant in the second time period (p = 0.42 and 0.03 for first and second periods, respectively). In crossover trial analysis, flocked swabs outperformed Dacron for cell count per slide based on slide imaging (p = 0.03), but Dacron and flocked swabs performed similarly based on erv-3 quantification (p = 0.14). Conclusions: Further studies should determine whether flocked swabs increase the representation of diagnostically important cells compared to Dacron. Copyright (C) 2011 S. Karger AG, Basel
C1 [Gage, Julia C.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH,DHHS,EPS, Rockville, MD 20852 USA.
[Borgonovo, Sylvia; Follansbee, Stephen] Kaiser Permanente San Francisco, Dept Med, Div Infect Dis, San Francisco, CA USA.
[Gravitt, Patti E.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA.
[Gravitt, Patti E.] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
[Castle, Philip E.] Amer Soc Clin Pathologists, Washington, DC USA.
[Grabe, Niels; Lahrmann, Bernd] Univ Heidelberg Hosp, Inst Med Biometry & Informat, Sect Med Informat, Heidelberg, Germany.
[Grabe, Niels; Lahrmann, Bernd] Hamamatsu Tissue Imaging & Anal Ctr, Heidelberg, Germany.
RP Gage, JC (reprint author), NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH,DHHS,EPS, 6120 Execut Blvd,MSC 7231, Rockville, MD 20852 USA.
EM gagej@mail.nih.gov
NR 13
TC 11
Z9 11
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0001-5547
J9 ACTA CYTOL
JI Acta Cytol.
PY 2011
VL 55
IS 4
BP 364
EP 367
DI 10.1159/000329488
PG 4
WC Pathology
SC Pathology
GA 801OE
UT WOS:000293448700010
PM 21791907
ER
PT J
AU Stewart, DM
Ramanathan, R
Mahanty, S
Fedorko, DP
Janik, JE
Morris, JC
AF Stewart, Donn M.
Ramanathan, Roshan
Mahanty, Siddhartha
Fedorko, Daniel P.
Janik, John E.
Morris, John C.
TI Disseminated Strongyloides stercoralis Infection in HTLV-1-Associated
Adult T-Cell Leukemia/Lymphoma
SO ACTA HAEMATOLOGICA
LA English
DT Article
DE Adult T-cell leukemia; Alemtuzumab; Corticosteroid; Disseminated
Strongyloides; HTLV-1; Human T-cell lymphotropic virus type-1
ID EOSINOPHIL COUNT; DIAGNOSIS; HTLV-1; IVERMECTIN; THIABENDAZOLE;
ALBENDAZOLE; EXPANSION; RESPONSES; CARRIERS; ANTIGEN
AB A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery. Copyright (C) 2011 S. Karger AG, Basel
C1 [Stewart, Donn M.] NCI, Metab Branch, Ctr Canc Res, Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA.
[Ramanathan, Roshan; Mahanty, Siddhartha] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA.
[Fedorko, Daniel P.] NIH, Microbiol Serv, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA.
RP Stewart, DM (reprint author), NCI, Metab Branch, Ctr Canc Res, Mark O Hatfield Clin Res Ctr, Room 4-5330,10 Ctr Dr, Bethesda, MD 20892 USA.
EM stewardo@mail.nih.gov
OI Mahanty, Siddhartha/0000-0003-1068-0524
FU Center for Cancer Research, National Cancer Institute; National
Institute of Allergy and Infectious Diseases, National Institutes of
Health
FX This study was supported in part by the Intramural Research Program of
the Center for Cancer Research, National Cancer Institute, and the
National Institute of Allergy and Infectious Diseases, National
Institutes of Health.
NR 33
TC 12
Z9 12
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0001-5792
J9 ACTA HAEMATOL-BASEL
JI Acta Haematol.
PY 2011
VL 126
IS 2
BP 63
EP 67
DI 10.1159/000324799
PG 5
WC Hematology
SC Hematology
GA 782WW
UT WOS:000292044400001
PM 21474923
ER
PT S
AU Gunzerath, L
Hewitt, BG
Li, TK
Warren, KR
AF Gunzerath, Lorraine
Hewitt, Brenda G.
Li, Ting-Kai
Warren, Kenneth R.
BE Uhl, GR
TI Alcohol research: past, present, and future
SO ADDICTION REVIEWS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE alcohol abuse; alcohol addiction; alcohol dependence; alcohol-use
disorders; alcoholism
ID COMMUNITY-REINFORCEMENT APPROACH; MANDATED COLLEGE-STUDENTS;
COGNITIVE-BEHAVIORAL TREATMENTS; NATIONAL EPIDEMIOLOGIC SURVEY;
EMPIRICALLY DERIVED TYPOLOGY; EVENT-RELATED OSCILLATIONS; SUBSTANCE USE
DISORDERS; SPECTRUM DISORDERS; UNITED-STATES; RECEPTOR GENE
AB Created forty years ago, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has played a major role in the great strides made in the understanding, treatment, prevention, and public acceptance of alcohol-use disorders. Throughout most of U.S. history "habitual drunkenness" was viewed as a problem of moral degeneracy or character flaw inherent in the individual. However, the wealth of scientific evidence amassed throughout NIAAA's history has established alcoholism as a medical condition, that is, as a disease for which affected individuals should feel no shame or be treated with disdain. We look at the developments in alcohol epidemiology, typology, etiology, prevention, and treatment research over the past 40 years. We also discuss how NIAAA addresses alcohol disorders from a life-course framework, affecting all stages of the lifespan, from fetus through child, adolescent, and young adult, to midlife/senior adult, with each stage involving different risks, consequences, prevention efforts, and treatment strategies.
C1 [Gunzerath, Lorraine; Hewitt, Brenda G.; Warren, Kenneth R.] NIAAA, NIH, Rockville, MD 20892 USA.
[Li, Ting-Kai] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA.
RP Gunzerath, L (reprint author), NIAAA, NIH, 5635 Fishers Lane, Rockville, MD 20892 USA.
EM Lg72x@nih.gov
NR 209
TC 15
Z9 17
U1 7
U2 22
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-812-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1216
BP 1
EP 23
DI 10.1111/j.1749-6632.2010.05832.x
PG 23
WC Substance Abuse; Multidisciplinary Sciences
SC Substance Abuse; Science & Technology - Other Topics
GA BTN80
UT WOS:000287434400001
PM 21182533
ER
PT S
AU Hommer, DW
Bjork, JM
Gilman, JM
AF Hommer, Daniel W.
Bjork, James M.
Gilman, Jodi M.
BE Uhl, GR
TI Imaging brain response to reward in addictive disorders
SO ADDICTION REVIEWS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE imaging; addiction; alcohol
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ENVIRONMENTAL RISK-FACTORS;
EVENT-RELATED FMRI; CONDUCT DISORDER; SUBSTANCE USE;
BEHAVIORAL-INHIBITION; ALCOHOL DEPENDENCE; NUCLEUS-ACCUMBENS; DOPAMINE
RELEASE; DETOXIFIED ALCOHOLICS
AB We compare the evidence from human neuroimaging studies for and against two of the major hypotheses of how alterations in the brain's reward system underlie addiction. One of these, the impulsivity hypothesis, proposes that addiction is characterized by excessive sensitivity to reward combined with a failure of inhibition. The other, the reward-deficiency hypothesis, proposes that addicted individuals have a reduced response to nondrug rewards that leads them to seek drugs in preference to more socially acceptable goals. Positron emission tomographic (PET) studies of dopamine receptor density and dopamine release strongly support the reward-deficiency hypothesis, while the more recent and numerous functional magnetic resonance imaging (fMRI) studies of goal-directed behavior provide both support and contradiction for each of the hypotheses. Differences in the time scale on which PET and fMRI make measurements probably account for differences in results, at least in part. It is likely that aspects of brain function described by both the impulsivity and reward-deficiency hypotheses contribute to the pathophysiology of addiction.
C1 [Hommer, Daniel W.] NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA.
[Bjork, James M.] Natl Inst Drug Abuse, Clin Neurosci Branch, Div Clin Neurosci & Behav Res, NIH, Bethesda, MD USA.
RP Hommer, DW (reprint author), NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA.
EM danh@mail.nih.gov
OI Bjork, James/0000-0003-0593-3291
NR 82
TC 72
Z9 73
U1 1
U2 17
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-812-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1216
BP 50
EP 61
DI 10.1111/j.1749-6632.2010.05898.x
PG 12
WC Substance Abuse; Multidisciplinary Sciences
SC Substance Abuse; Science & Technology - Other Topics
GA BTN80
UT WOS:000287434400004
PM 21272010
ER
PT S
AU Eiden, LE
Weihe, E
AF Eiden, Lee E.
Weihe, Eberhard
BE Uhl, GR
TI VMAT2: a dynamic regulator of brain monoaminergic neuronal function
interacting with drugs of abuse
SO ADDICTION REVIEWS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE VMAT2; amphetamine; cocaine; addiction; monoamines; vesicular
transporter
ID VESICULAR AMINE TRANSPORTER; HETEROZYGOTE KNOCKOUT MICE; DOPAMINE
TRANSPORTER; NEUROTRANSMITTER TRANSPORTERS; STRIATAL DOPAMINE;
NERVOUS-SYSTEM; VESICULAR-MONOAMINE-TRANSPORTER-1 GENE; ACETYLCHOLINE
TRANSPORTER; METHAMPHETAMINE USERS; ENDOCRINE-CELLS
AB The monoaminergic neuron, in particular the dopaminergic neuron, is central to mediating the hedonic and addictive properties of drugs of abuse. The effects of amphetamine (AMPH) and cocaine (COC), for example, depend on the ability to increase dopamine in the synapse, by effects on either the plasma membrane transporter DAT or the vesicular transporter for monoamine storage, VMAT2. The potential role of DAT as a target for AMPH and COG has been reviewed extensively. Here, we present VMAT2 as a target that enables the rewarding and addictive actions of these drugs, based on imaging, neurochemical, biochemical, cell biological, genetic, and immunohistochemical evidence. The presence of VMAT2 in noradrenergic, serotoninergic, histaminergic, and potentially trace aminergic neurons invites consideration of a wider role for aminergic neurotransmission in AMPH and COC abuse and addiction.
C1 [Eiden, Lee E.] NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA.
[Weihe, Eberhard] Univ Marburg, Inst Anat & Cell Biol, Marburg, Germany.
RP Eiden, LE (reprint author), Bldg 49,Room 5A-38,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM eidenl@mail.nih.gov
OI Eiden, Lee/0000-0001-7524-944X
FU Intramural NIH HHS [ZIA MH002386-28, Z01 MH002386-21, Z01 MH002386-22,
Z99 MH999999, ZIA MH002386-23, ZIA MH002386-24, ZIA MH002386-25, ZIA
MH002386-26, ZIA MH002386-27]
NR 91
TC 39
Z9 41
U1 2
U2 17
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-812-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1216
BP 86
EP +
DI 10.1111/j.1749-6632.2010.05906.x
PG 4
WC Substance Abuse; Multidisciplinary Sciences
SC Substance Abuse; Science & Technology - Other Topics
GA BTN80
UT WOS:000287434400007
PM 21272013
ER
PT J
AU Marshall, MM
Kirk, GD
Caporaso, NE
McCormack, MC
Merlo, CA
Hague, JC
Mehta, SH
Engels, EA
AF Marshall, Mariah M.
Kirk, Gregory D.
Caporaso, Neil E.
McCormack, Meredith C.
Merlo, Christian A.
Hague, John C.
Mehta, Shruti H.
Engels, Eric A.
TI Tobacco use and nicotine dependence among HIV-infected and uninfected
injection drug users
SO ADDICTIVE BEHAVIORS
LA English
DT Article
DE Injection drug use; HIV infection; Smoking; Nicotine dependence; Tobacco
ID FAGERSTROM TOLERANCE QUESTIONNAIRE; IMMUNODEFICIENCY-VIRUS-INFECTION;
NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; LUNG-CANCER;
ANTIRETROVIRAL THERAPY; SMOKING-CESSATION; CIGARETTE-SMOKING;
UNITED-STATES; RISK
AB Introduction Urban U S populations are burdened by intersecting epidemics of HIV infection injection drug use and cigarette smoking Given the substantial morbidity attributable to tobacco in these populations we characterized smoking behaviors nicotine addiction and tobacco exposure among HIV-infected and HIV uninfected injection drug users (IDUs) in Baltimore Maryland
Methods Smoking behaviors among participants in the ALIVE Study were assessed using interviewer administered questionnaires Smoking history and nicotine dependence (Fagerstrom Index scores) were compared by HIV and drug injecting status Serum cotinine (a nicotine metabolite) was measured for a sample of participants by enzyme immunoassay
Results Among 1052 participants (29 7% HIV-infected 39 8% active injectors) 85 2% were current smokers and 9 3% were former smokers Smoking prevalence age at smoking initiation and cumulative tobacco exposure were similar by HIV status Median Fagerstrom scores of 4 for HIV infected and HIV uninfected smokers indicated moderate nicotine dependence Daily cigarette consumption was identical by HIV status (median 10 cigarettes) although HIV infected participants were less likely to smoke 1+ pack daily compared to HIV-uninfected participants (18 0% vs 26 9% p = 0 001) Compared to former injectors active injectors had higher smoking prevalence (90 5% vs 81 7% p = 0 0001) greater daily cigarette consumption (30 7% vs 19 6% smoked 1+ pack daily p = 0 0001) and slightly higher Fagerstrom scores (median 5 vs 4) Cotinine levels paralleled self reported cigarette consumption
Discussion Tobacco use is extremely common among inner-city IDUs Smoking behavior and nicotine dependence did not materially differ by HIV status but were associated with active drug injection Cessation efforts should target the dual dependence of cigarettes and drugs experienced among this population (C) 2010 Elsevier Ltd All rights reserved
C1 [Marshall, Mariah M.; Kirk, Gregory D.; McCormack, Meredith C.; Hague, John C.; Mehta, Shruti H.] Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Kirk, Gregory D.; McCormack, Meredith C.; Merlo, Christian A.; Engels, Eric A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
[Caporaso, Neil E.; Engels, Eric A.] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA.
RP Marshall, MM (reprint author), Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
FU NIH [R01HL090483, R01DA04334, R01DAl2568]; National Cancer Institute
FX Funding for this study was provided by NIH grants R01HL090483 R01DA04334
and R01DAl2568 and by the Intramural Research Program of the National
Cancer Institute
NR 44
TC 34
Z9 34
U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4603
EI 1873-6327
J9 ADDICT BEHAV
JI Addict. Behav.
PD JAN-FEB
PY 2011
VL 36
IS 1-2
BP 61
EP 67
DI 10.1016/j.addbeh.2010.08.022
PG 7
WC Psychology, Clinical; Substance Abuse
SC Psychology; Substance Abuse
GA 694VK
UT WOS:000285326900009
PM 20875704
ER
PT B
AU Mazaki-Tovi, S
Kusanovic, JP
Vaisbuch, E
Romero, R
AF Mazaki-Tovi, Shali
Kusanovic, Juan Pedro
Vaisbuch, Edi
Romero, Roberto
BE Preedy, VR
Hunter, RJ
TI Resistin in Amniotic Fluid
SO ADIPOKINES
SE Modern Insights into Disease from Molecules to Man
LA English
DT Article; Book Chapter
ID SERUM ADIPONECTIN MULTIMERS; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE;
NORMAL-PREGNANCY; PRETERM LABOR; ADIPOSE-TISSUE; COMPLICATED
PREGNANCIES; INTRAAMNIOTIC INFECTION; INFLAMMATION; ASSOCIATION
AB Resistin, a novel adipocytokine, has been implicated in the regulation of the innate immune response. Specifically, resistin has pro-inflammatory properties that are abrogated by NF-kappa B inhibitor, indicating the importance of NF-kappa B signaling pathway for resistin-induced inflammation. Consistent with this view, circulating plasma resistin concentrations are increased in patients with sepsis, and it has been proposed that plasma concentrations of this adipocytokine can serve as a marker of sepsis severity. Resistin has also been detected in several body fluids, including saliva, urine and synovial fluid. Indeed, resistin accumulates in the inflamed joints of patients with rheumatoid arthritis and its synovial concentrations correlate with other markers of inflammation. Recently, resistin was found to be a physiological constituent of amniotic fluid. In addition, high amniotic fluid resistin concentrations are associated with intra-amniotic infection and/or inflammation, and amniotic fluid resistin concentrations are associated with well-established indices of intra-amniotic inflammation such as amniotic fluid interleukin (IL) 6 concentration and white blood cell count, as well as with amniocentesis-to-delivery interval. The strong association with intra-amniotic infection/inflammation has been corroborated in an unbiased, high-throughput proteomics analysis of amniotic fluid. The aim of this chapter is to present the available evidence regarding amniotic fluid resistin and to discuss their importance and possible implications.
C1 [Mazaki-Tovi, Shali; Kusanovic, Juan Pedro; Vaisbuch, Edi; Romero, Roberto] Wayne State Univ, Dept Obstet & Gynecol, Perinatol Res Branch, Intramural Div,NICHD NIH DHHS,Hutzel Womens Hosp, Detroit, MI 48201 USA.
RP Romero, R (reprint author), Wayne State Univ, Dept Obstet & Gynecol, Perinatol Res Branch, Intramural Div,NICHD NIH DHHS,Hutzel Womens Hosp, 3990 John R, Detroit, MI 48201 USA.
NR 33
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4398-7988-7; 978-1-57808-689-4
J9 MOD INSIGHTS DIS MOL
JI Mod. Insights Dis. Mol. Man
PY 2011
BP 404
EP 418
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BC2ZE
UT WOS:000351460700037
ER
PT J
AU Krueger, F
Grafman, J
AF Krueger, Frank
Grafman, Jordan
BE Wolf, LE
Schreiber, HE
Wasserstein, J
TI Disorders of Mathematics Implications for Adult Functioning
SO ADULT LEARNING DISORDERS: CONTEMPORARY ISSUES
SE Neuropsychologists Handbook
LA English
DT Article; Book Chapter
ID LOW-BIRTH-WEIGHT; OF-PROCESSING DIFFERENCES; COTTON-TOP TAMARINS;
FRAGILE-X-SYNDROME; DEVELOPMENTAL DYSCALCULIA; LEARNING-DISABILITIES;
MENTAL CALCULATION; COGNITIVE NEUROPSYCHOLOGY; CORTICAL ACTIVATION;
BRAIN POTENTIALS
C1 [Krueger, Frank; Grafman, Jordan] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA.
RP Krueger, F (reprint author), Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA.
NR 207
TC 0
Z9 0
U1 3
U2 3
PU TAYLOR & FRANCIS LTD
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-1-84169-419-1
J9 NEUROPSYCHOLOGIST HB
PY 2011
BP 191
EP 218
PG 28
WC Behavioral Sciences; Education, Special; Psychology, Developmental;
Neurosciences; Psychology
SC Behavioral Sciences; Education & Educational Research; Psychology;
Neurosciences & Neurology
GA BUQ06
UT WOS:000290022300009
ER
PT J
AU Amornphimoltham, P
Masedunskas, A
Weigert, R
AF Amornphimoltham, Panomwat
Masedunskas, Andrius
Weigert, Roberto
TI Intravital microscopy as a tool to study drug delivery in preclinical
studies
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Intravital microscopy; Non-linear microscopy; Drug delivery; Cancer
ID RAMAN SCATTERING MICROSCOPY; DORSAL SKINFOLD CHAMBER; CELLS IN-VIVO;
2-PHOTON MICROSCOPY; MULTIPHOTON MICROSCOPY; FLUORESCENCE MICROSCOPY;
DENDRITIC CELLS; QUANTUM DOTS; LYMPH-NODES; 2ND-HARMONIC GENERATION
AB The technical developments in the field of non-linear microscopy have made intravital microscopy one of the most successful techniques for studying physiological and pathological processes in live animals. Intravital microscopy has been utilized to address many biological questions in basic research and is now a fundamental tool for preclinical studies, with an enormous potential for clinical applications. The ability to dynamically image cellular and subcellular structures combined with the possibility to perform longitudinal studies have empowered investigators to use this discipline to study the mechanisms of action of therapeutic agents and assess the efficacy on their targets in vivo. The goal of this review is to provide a general overview of the recent advances in intravital microscopy and to discuss some of its applications in preclinical studies. Published by Elsevier B.V.
C1 [Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto] Natl Inst Dent & Craniofacial Res, Intracellular Membrane Trafficking Unit, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
RP Weigert, R (reprint author), Natl Inst Dent & Craniofacial Res, Intracellular Membrane Trafficking Unit, Oral & Pharyngeal Canc Branch, NIH, 30 Convent Dr,Room 303A, Bethesda, MD 20892 USA.
EM weigertr@mail.nih.gov
OI Masedunskas, Andrius/0000-0002-4533-5467
FU NIH, National Institute of Dental and Craniofacial Research. (NIDCR)
FX This research was supported by the Intramural Research Program of the
NIH, National Institute of Dental and Craniofacial Research. (NIDCR) We
apologize to those whose work could not be cited due to space
limitations.
NR 163
TC 25
Z9 27
U1 2
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-409X
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD JAN-FEB
PY 2011
VL 63
IS 1-2
BP 119
EP 128
DI 10.1016/j.addr.2010.09.009
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 760WC
UT WOS:000290353900008
PM 20933026
ER
PT S
AU Shears, SB
Gokhale, NA
Wang, HC
Zaremba, A
AF Shears, Stephen B.
Gokhale, Nikhil A.
Wang, Huanchen
Zaremba, Angelika
BE Cocco, L
Weber, G
Weber, CEF
TI Diphosphoinositol polyphosphates: What are the mechanisms?
SO ADVANCES IN ENZYME REGULATION, VOL 51
SE Advances in Enzyme Regulation
LA English
DT Proceedings Paper
CT 51st International Symposium on Regulations of Enzyme Activity and
Synthesis in Normal and Neoplastic Tissues
CY OCT 04-05, 2010
CL Univ Bologna, Bologna, ITALY
HO Univ Bologna
ID INOSITOL HEXAKISPHOSPHATE KINASE; ACTIVATED PROTEIN-KINASE; PLECKSTRIN
HOMOLOGY DOMAINS; HYPEROSMOTIC STRESS; SACCHAROMYCES-CEREVISIAE;
CELL-DEATH; GENE-EXPRESSION; HEAT-SHOCK; PYROPHOSPHATES;
TETRAKISPHOSPHATE
C1 [Shears, Stephen B.; Gokhale, Nikhil A.; Wang, Huanchen; Zaremba, Angelika] NIEHS, Inositol Signaling Grp, Lab Signal Transduct, NIH,DHHS, Res Triangle Pk, NC 27709 USA.
RP Shears, SB (reprint author), NIEHS, Inositol Signaling Grp, Lab Signal Transduct, NIH,DHHS, POB 12233, Res Triangle Pk, NC 27709 USA.
EM Shears@niehs.nih.gov
FU Intramural NIH HHS [ZIA ES080046-24]
NR 91
TC 18
Z9 19
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0065-2571
J9 ADV ENZYME REGUL
JI Adv. Enzym. Regul.
PY 2011
VL 51
BP 13
EP 25
DI 10.1016/j.advenzreg.2010.09.008
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BWE12
UT WOS:000293715300002
PM 21035493
ER
PT B
AU Shamir, L
AF Shamir, Lior
BA Zhang, YJ
BF Zhang, YJ
TI Pose and Illumination Invariance with Compound Image Transforms
SO ADVANCES IN FACE IMAGE ANALYSIS: TECHNIQUES AND TECHNOLOGIES
LA English
DT Article; Book Chapter
ID FACE-RECOGNITION; EIGENFACES
AB While current face recognition algorithms have provided convincing performance on frontal face poses, recognition is far less effective when the pose and illumination conditions vary. Here the authors show how compound image transforms can be used for face recognition in various poses and illumination conditions. The method works by first dividing each image into four equal-sized tiles. Then, image features are extracted from the face images, transforms of the images, and transforms of transforms of the images. Finally, each image feature is assigned with a Fisher score, and test images are classified by using a simple Weighted Nearest Neighbor rule such that the Fisher scores are used as weights. Experimental results using the full color FERET dataset show that with no parameter tuning, the accuracy of rank-10 recognition for frontal, quarter-profile, and half-profile images is similar to 98%, similar to 94% and similar to 91%, respectively. The proposed method also achieves perfect accuracy on several other face recognition datasets such as Yale B, ORL and JAFFE. An important feature of this method is that the recognition accuracy improves as the number of subjects in the dataset gets larger.
C1 [Shamir, Lior] NIA, NIH, Bethesda, MD 20892 USA.
RP Shamir, L (reprint author), NIA, NIH, Bethesda, MD 20892 USA.
NR 47
TC 1
Z9 1
U1 0
U2 0
PU IGI GLOBAL
PI HERSEY
PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA
BN 978-1-61520-992-7; 978-1-61520-991-0
PY 2011
BP 301
EP 315
DI 10.4018/978-1-61520-991-0.ch016
D2 10.4018/978-1-61520-991-0
PG 15
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BD7PA
UT WOS:000363412500017
ER
PT S
AU Shevach, EM
AF Shevach, Ethan M.
BE Rudensky, A
Sakaguchi, S
TI Biological Functions of Regulatory T Cells
SO ADVANCES IN IMMUNOLOGY: REGULATORY T-CELLS, VOL 112
SE Advances in Immunology
LA English
DT Review; Book Chapter
ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM;
DENDRITIC CELLS; TGF-BETA; IN-VIVO; CUTTING EDGE; IMMUNE-RESPONSES;
LYMPH-NODE; CD4(+)CD25(+); INDUCTION
AB The subpopulation of CD4(+) T lymphocytes that co-express the transcription factor Foxp3 plays a unique role as regulatory T lymphocytes (Tregs) that modulate many aspects of the immune response. Multiple mechanisms have been proposed for the suppressor function of CD4(+)Foxp3(+) T cells based on in vitro studies, but much less is known about how Tregs suppress immune responses in vivo. Both polyclonal Tregs and antigen-specific Tregs are capable of exerting potent suppressive effects in vivo, and it is likely that they mediate their biologic functions using different mechanisms. Antigen-specific Tregs primarily target dendritic cells and inhibit dendritic cell functions including the expression of costimulatory molecules and the presentation of antigen early during the generation of the immune response. The end result is a complete inhibition of both the expansion and the differentiation of T effector cells. Polyclonal Tregs also act on dendritic cells, but at a later phase, and do not inhibit expansion of T effector cells, but appear to modulate differentiation and cell trafficking. The cell surface molecules involved in the interaction of Tregs with dendritic cells, as well as the biochemical pathways modified by this interaction remain to be fully elucidated. A complete understand of the biological functions of Tregs in vivo should facilitate the development of pharmacologic and biologic agents that can be used to modulate Treg function in a therapeutic setting.
C1 NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
RP Shevach, EM (reprint author), NIAID, Immunol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA.
FU Intramural NIH HHS
NR 71
TC 69
Z9 71
U1 3
U2 10
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2776
BN 978-0-12-387827-4
J9 ADV IMMUNOL
JI Adv.Immunol.
PY 2011
VL 112
BP 137
EP 176
DI 10.1016/B978-0-12-387827-4.00004-8
PG 40
WC Immunology
SC Immunology
GA BYN00
UT WOS:000299395600004
PM 22118408
ER
PT S
AU Liu, ZG
AF Liu, Zhenggang
BE Wallach, D
Kovalenko, A
Feldman, M
TI ATIA, A MULTI-TASK PROTEIN THAT PROTECTS CELLS AGAINST TNF-INDUCED
APOPTOSIS
SO ADVANCES IN TNF FAMILY RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Meeting Abstract
CT 12th Biennial International TNF Conference
CY APR, 2009
CL San Lorenzo del Escorial, SPAIN
C1 [Liu, Zhenggang] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-1-4419-6611-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 691
BP 736
EP 737
PG 2
WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Immunology; Research & Experimental Medicine
GA BVG74
UT WOS:000291501300186
ER
PT J
AU Royall, J
Lyon, B
AF Royall, J.
Lyon, B.
TI Sea-Change or Change Challenge? Health Information access in Developing
Countries: The US National Library of Medicine experience
SO AFRICAN HEALTH SCIENCES
LA English
DT Article
AB Health professionals in developing countries want access to information to help them make changes in health care and contribute to medical research. However, they face challenges of technology limitations, lack of training, and, on the village level, culture and language.
This report focuses on the U. S. National Library of Medicine experience with access: for the international medical/scientific community to health information which has been published by researchers in developing countries; for scientists and clinicians in developing countries to their own literature and to that of their colleagues around the world; for medical librarians who are a critical conduit for students, faculty, researchers, and, increasingly, the general public; and for the front line workers at the health center in the village at the end of the line.
The fundamental question of whether or not information communication technology can make a difference in access and subsequently in health is illustrated by an anecdote regarding an early intervention in Africa in 1992. From that point, we examine programs to improve access involving malaria researchers, medical journal editors, librarians, and medical students working with local health center staff in the village. Although access is a reality, the positive change in health that the information technology intervention might produce often remains a mirage. Information and technology are not static elements in the equation for better access. They must function together, creating a dialectic in which they transform and inform one another and those whom their combination touches. African Health Sciences 2011; 11(3): 457 - 463
C1 [Royall, J.; Lyon, B.] NIH, Natl Lib Med, Bethesda, MD 20894 USA.
RP Royall, J (reprint author), NIH, Natl Lib Med, 8600 Rockville Pike Bldg 38,Room 2S-22, Bethesda, MD 20894 USA.
EM jroyall@nlm.nih.gov
NR 7
TC 6
Z9 6
U1 0
U2 7
PU MAKERERE UNIV, FAC MED
PI KAMPALA
PA PO BOX 7072, KAMPALA, 00000, UGANDA
SN 1680-6905
J9 AFR HEALTH SCI
JI Afr. Health Sci.
PY 2011
VL 11
IS 3
BP 457
EP 463
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 970ZN
UT WOS:000306171400026
PM 22275940
ER
PT J
AU Kamrava, M
Gius, D
Casagrande, G
Kohn, E
AF Kamrava, Mitchell
Gius, David
Casagrande, Giovanna
Kohn, Elise
TI Will targeting insulin growth factor help us or hurt us?: An
oncologist's perspective
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Insulin growth factor; Cancer; Aging
ID FACTOR-I RECEPTOR; IGF-BINDING PROTEIN-3; LIFE-SPAN EXTENSION; CELL-CELL
ADHESION; BREAST-CANCER CELLS; CAENORHABDITIS-ELEGANS; DWARF MICE;
CALORIE RESTRICTION; EXTENDED LONGEVITY; FACTOR (IGF)-I
AB The insulin/insulin growth factor (IGF) pathway is a critical mediator of longevity and aging. Efforts to extend longevity by altering the insulin/IGF pathway may have varying effects on other physiological processes. Reduced insulin/IGF levels may decrease the incidence of certain cancers as well as the risk of developing metastatic disease. However, it may also increase the risk of developing cardiovascular disease as well as cardiovascular related mortality. Pursuing the right insulin/IGF pathway targets will require striking a balance between inhibiting cancer cell development and progression and avoiding damage to tissues under normal insulin/IGF-mediated control. This review will discuss the roles of the insulin/IGF pathway in aging and longevity and the development of cancer cell metastasis and considerations in taking insulin/IGF directed targets to the oncology clinic. Published by Elsevier Ireland Ltd.
C1 [Casagrande, Giovanna; Kohn, Elise] NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Kamrava, Mitchell; Gius, David] NCI, Mol Radiat Oncol Sect, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Kohn, E (reprint author), NCI, Med Oncol Branch, Ctr Canc Res, 10 Ctr Dr,MSC 1906, Bethesda, MD 20892 USA.
EM kohne@mail.nih.gov
FU NIH, National Cancer Institute, Center for Cancer Research
FX This research was supported by the Intramural Research Program of the
NIH, National Cancer Institute, Center for Cancer Research.
NR 99
TC 4
Z9 4
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1568-1637
J9 AGEING RES REV
JI Ageing Res. Rev.
PD JAN
PY 2011
VL 10
IS 1
SI SI
BP 62
EP 70
DI 10.1016/j.arr.2009.10.007
PG 9
WC Cell Biology; Geriatrics & Gerontology
SC Cell Biology; Geriatrics & Gerontology
GA 717SY
UT WOS:000287068900007
PM 19896561
ER
PT J
AU Horikawa, I
Fujita, K
Harris, CC
AF Horikawa, Izumi
Fujita, Kaori
Harris, Curtis C.
TI p53 governs telomere regulation feedback too, via TRF2
SO AGING-US
LA English
DT Article
DE telomere uncapping; p53; ubiquitin ligase; TRF2; feedback regulation
ID CELLULAR SENESCENCE; DNA-DAMAGE; STEM-CELLS; REPLICATIVE SENESCENCE;
HUMAN-CHROMOSOMES; MUTANT P53; ATM; OVERHANG; PATHWAY; CANCER
AB p53 takes critical part in a number of positive and negative feedback loops to regulate carcinogenesis, aging and other biological processes. Uncapped or dysfunctional telomeres are an endogenous DNA damage that activates ATM kinase (ataxia telangiectasia mutated) and then p53 to induce cellular senescence or apoptosis. Our recent study shows that p53, a downstream effector of the telomere damage signaling, also functions upstream of the telomere-capping protein complex by inhibiting one of its components, TRF2 (telomeric repeat binding factor 2). Since TRF2 inhibition leads to ATM activation, a novel positive feedback loop exists to amplify uncapped telomere-induced, p53-mediated cellular responses. Siah1 (seven in absentia homolog 1), a p53-inducible E3 ubiquitin ligase, plays a key role in this feedback regulation by targeting TRF2 for ubiquitination and proteasomal degradation. Biological significance and therapeutic implications of this study are discussed.
C1 [Horikawa, Izumi; Fujita, Kaori; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA.
RP Harris, CC (reprint author), NCI, Human Carcinogenesis Lab, NIH, Bldg 37, Bethesda, MD 20892 USA.
EM Curtis_Harris@nih.gov
NR 49
TC 24
Z9 25
U1 0
U2 4
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JAN
PY 2011
VL 3
IS 1
BP 26
EP 32
PG 7
WC Cell Biology
SC Cell Biology
GA 722FS
UT WOS:000287417900010
PM 21266744
ER
PT J
AU Newman, AB
Glynn, NW
Taylor, CA
Sebastiani, P
Perls, TT
Mayeux, R
Christensen, K
Zmuda, JM
Barral, S
Lee, JH
Simonsick, EM
Walston, JD
Yashin, AI
Hadley, E
AF Newman, Anne B.
Glynn, Nancy W.
Taylor, Christopher A.
Sebastiani, Paola
Perls, Thomas T.
Mayeux, Richard
Christensen, Kaare
Zmuda, Joseph M.
Barral, Sandra
Lee, Joseph H.
Simonsick, Eleanor M.
Walston, Jeremy D.
Yashin, Anatoli I.
Hadley, Evan
TI Health and function of participants in the Long Life Family Study: A
comparison with other cohorts
SO AGING-US
LA English
DT Article
DE longevity; exceptional survival; family studies; genetics; healthy
aging; genome wide association study; multicenter studies; aging
phenotypes
ID CARDIOVASCULAR-DISEASE; PULMONARY-FUNCTION; LIVED PARENTS;
HEART-DISEASE; MORTALITY; AGE; FRAMINGHAM; DISABILITY; LONGEVITY;
CENTENARIANS
AB Individuals from families recruited for the Long Life Family Study (LLFS) (n=4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.
C1 [Newman, Anne B.; Glynn, Nancy W.; Taylor, Christopher A.; Zmuda, Joseph M.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Ctr Aging & Populat Hlth, Pittsburgh, PA 15213 USA.
[Newman, Anne B.] Univ Pittsburgh, Sch Med, Div Geriatr Med, Pittsburgh, PA 15261 USA.
[Sebastiani, Paola] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.
[Perls, Thomas T.] Boston Univ, Med Ctr, Dept Med, Div Geriatr, Boston, MA 02118 USA.
[Mayeux, Richard; Barral, Sandra; Lee, Joseph H.] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA.
[Mayeux, Richard; Barral, Sandra; Lee, Joseph H.] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA.
[Christensen, Kaare] Univ So Denmark, Danish Aging Res Ctr, Odense, Denmark.
[Simonsick, Eleanor M.; Hadley, Evan] NIA, NIH, Bethesda, MD 20892 USA.
[Walston, Jeremy D.] Johns Hopkins Med Inst, Bayview Med Ctr, Baltimore, MD 21224 USA.
[Yashin, Anatoli I.] Duke Univ, Ctr Demog Studies, Durham, NC 27708 USA.
RP Newman, AB (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Ctr Aging & Populat Hlth, Pittsburgh, PA 15213 USA.
EM newmana@edc.pitt.edu
RI Christensen, Kaare/C-2360-2009; Lee, Joseph/D-2441-2012; Newman,
Anne/C-6408-2013;
OI Christensen, Kaare/0000-0002-5429-5292; Lee, Joseph/0000-0002-2000-4821;
Newman, Anne/0000-0002-0106-1150; sebastiani, paola/0000-0001-6419-1545;
Glynn, Nancy/0000-0003-2265-0162
FU National Institute on Aging (NIA) [U01-AG023712, U01-AG23744,
U01-AG023746, U01-AG023749, U01-AG023755, AG-023629, R01 AG-15928, R01
AG-20098, AG-027058, 5K24AG025727]; National Heart, Lung, and Blood
Institute [N01-HC-85079, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01
HC-55222, N01-HC-75150, N01-HC-45133, U01 HL080295, R01 HL-075366];
University of Pittsburgh Claude; NHLBI; FHS
FX LLFS : Sponsored by the National Institute on Aging (NIA cooperative
agreements U01-AG023712, U01-AG23744, U01-AG023746, U01-AG023749 and
U01-AG023755). CHS: The research reported in this article was supported
by the National Institute on Aging AG-023629. CHS was supported by
contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01
HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant number U01
HL080295 from the National Heart, Lung, and Blood Institute, with
additional contribution from the National Institute of Neurological
Disorders and Stroke. Additional support was provided through R01
AG-15928, R01 AG-20098, and AG-027058 from the National Institute on
Aging, R01 HL-075366 from the National Heart, Lung and Blood Institute,
and the University of Pittsburgh Claude. D. Pepper Older Americans
Independence Center P30-AG-024827. A full list of principal CHS
investigators and institutions can be found at
http://www.chs-nhlbi.org/pi.htm. FHS: The Framingham Heart Study is
conducted and supported by the NHLBI in collaboration with the FHS
Investigators. This manuscript was prepared using limited access
datasets obtained from the NHLBI and does not necessarily reflect the
opinions or views of the FHS or the NHLBI. NECS: This research was
supported by the National Institute on Aging (NIA) 5K24AG025727,
Characterizing Human Exceptional Longevity.
NR 32
TC 50
Z9 51
U1 1
U2 4
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JAN
PY 2011
VL 3
IS 1
BP 63
EP 76
PG 14
WC Cell Biology
SC Cell Biology
GA 722FS
UT WOS:000287417900014
PM 21258136
ER
PT J
AU Imamichi, H
DeGray, G
Asmuth, DM
Fischl, MA
Landay, AL
Lederman, MM
Sereti, I
AF Imamichi, Hiromi
DeGray, Gerald
Asmuth, David M.
Fischl, Margaret A.
Landay, Alan L.
Lederman, Michael M.
Sereti, Irini
TI HIV-1 viruses detected during episodic blips following interleukin-7
administration are similar to the viruses present before and after
interleukin-7 therapy
SO AIDS
LA English
DT Article
DE HIV-1; interleukin-7; quasispecies; transient HIV viremia; virus
reservoir
ID IL-7; TYPE-1; EXPRESSION; MACAQUES
AB Background: Administration of recombinant human interleukin (IL)-7 leads to CD4 and CD8 T-cell expansions in HIV-infected individuals, demonstrating promising capacity for immune reconstitution. However, a proportion of patients treated with recombinant human IL-7 experience transient increases in plasma HIV-RNA ('blips'), possibly reflecting 'purging' of a quiescent reservoir that provides a barrier to viral eradication.
Objective: To identify the sources of HIV detected during transient viremic episodes following IL-7 administration, viral quasispecies were analyzed in a total of 281 primary sequences derived from seven patients who experienced the episodic blips following IL-7 therapy.
Method: The C2-V3 regions of the HIV-1 env gene were sequenced from HIV-1 RNA in plasma and HIV DNA from peripheral blood mononuclear cells (PBMCs) obtained at baseline (day 0 of recombinant human IL-7 therapy), during the episode of viral blips (day 4), and at a time when levels of plasma HIV-RNA had returned to less than 50 copies/ml (day 28).
Results: The HIV sequences detected during transient viremia following IL-7 administration were closely related to those of the plasma viruses present before and after cytokine administration. All virus quasispecies detected during blips were also present in proviral sequences in PBMCs.
Conclusion: The low level viremia induced by IL-7 likely reflects predominantly transient induction or release of virus from a preexisting pool rather than activation of silent quasispecies. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Imamichi, Hiromi; Sereti, Irini] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[DeGray, Gerald] NCI, Lab Mol Retrovirol, Clin Serv Program, SAIC Frederick Inc, Frederick, MD USA.
[Asmuth, David M.] Univ Calif, Davis Med Ctr, Sacramento, CA USA.
[Fischl, Margaret A.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
[Landay, Alan L.] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
[Lederman, Michael M.] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA.
RP Imamichi, H (reprint author), NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bldg 550,Room 201-A,POB B, Frederick, MD 21702 USA.
EM himamichi@nih.gov
FU National Institute of Allergy and Infectious Diseases; Individual AIDS
Clinical Trials Units at Case Western Reserve University [AI 25879];
Rush University [AI 68636]; Northwestern University [AI 25915];
University of California; Davis Medical Center [AI 38858]; University of
Miami [AI 27675]; Cytheris; National Cancer Institute, National
Institutes of Health [HHSN261200800001E]; National institute of Allergy
and infectious Disease (NIAID), National Institutes of Health
[HHSN261200800001E]; NIAID
FX The present study was supported in part by the AIDS Clinical Trials
Group funded by the National Institute of Allergy and Infectious
Diseases and the individual AIDS Clinical Trials Units at Case Western
Reserve University (AI 25879), Rush University (AI 68636), Northwestern
University (AI 25915), University of California, Davis Medical Center
(AI 38858), and University of Miami (AI 27675). This work was also
supported in part by the Intramural Research Program of the National
Institutes of Health, National Institute of Allergy and Infectious
Diseases. The authors thank all study participants and the ACTG5214
study team.; M.M.L. has received research support from Cytheris. All
other authors have declared no conflict of interest.; This project has
been funded in part by federal funds from the National Cancer Institute,
National Institutes of Health, under contract HHSN261200800001E, the
National institute of Allergy and infectious Disease (NIAID), National
Institutes of Health, under contract HHSN261200800001E and by the
Intramural Research Program of NIAID. The content of this publication
does not necessarily reflect the views or policies of the Department of
Health and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the US Government.
NR 14
TC 26
Z9 27
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD JAN
PY 2011
VL 25
IS 2
BP 159
EP 164
DI 10.1097/QAD.0b013e328340a270
PG 6
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 697GT
UT WOS:000285501900005
PM 21124203
ER
PT J
AU Booth, RE
Campbell, BK
Mikulich-Gilbertson, SK
Tillotson, CJ
Choi, D
Robinson, J
Calsyn, DA
Mandler, RN
Jenkins, LM
Thompson, LL
Dempsey, CL
Liepman, MR
McCarty, D
AF Booth, Robert E.
Campbell, Barbara K.
Mikulich-Gilbertson, Susan K.
Tillotson, Carrie J.
Choi, Dongseok
Robinson, James
Calsyn, Donald A.
Mandler, Raul N.
Jenkins, Lindsay M.
Thompson, Laetitia L.
Dempsey, Catherine L.
Liepman, Michael R.
McCarty, Dennis
TI Reducing HIV-Related Risk Behaviors Among Injection Drug Users in
Residential Detoxification
SO AIDS AND BEHAVIOR
LA English
DT Article
DE Drug injection; Risk reduction; Treatment entry; Detoxification
ID OUT-OF-TREATMENT; HUMAN-IMMUNODEFICIENCY-VIRUS; GENDER-DIFFERENCES;
HEPATITIS-C; METHADONE-MAINTENANCE; ABUSE TREATMENT; OUTPATIENT
TREATMENT; AIDS-PREVENTION; TREATMENT ENTRY; SAN-FRANCISCO
AB This study of 632 drug injectors enrolled in eight residential detoxification centers within the National Drug Abuse Treatment Clinical Trials Network tested three interventions to reduce drug and sex risk behaviors. Participants were randomized to: (a) a two-session, HIV/HCV counseling and education (C&E) model added to treatment as usual (TAU), (b) a one-session, therapeutic alliance (TA) intervention conducted by outpatient counselors to facilitate treatment entry plus TAU, or (c) TAU. Significant reductions in drug and sex risk behaviors occurred for all three conditions over a 6-month follow-up period. C&E participants reported significantly greater rates of attending an HIV testing appointment, but this was not associated with better risk reduction outcomes. Reporting treatment participation within 2 months after detoxification and self-efficacy to practice safer injection behavior predicted reductions in injection risk behaviors. Findings indicate that participation in detoxification was followed by significant decreases in drug injection and risk behaviors for up to 6-months; interventions added to standard treatment offered no improvement in risk behavior outcomes.
C1 [Campbell, Barbara K.; Choi, Dongseok; McCarty, Dennis] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA.
[Booth, Robert E.; Mikulich-Gilbertson, Susan K.; Thompson, Laetitia L.; Dempsey, Catherine L.] Univ Colorado, Dept Psychiat, Denver, CO 80202 USA.
[Tillotson, Carrie J.] Oregon Hlth & Sci Univ, Oregon Clin & Translat Res Inst, Portland, OR 97239 USA.
[Robinson, James] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
[Calsyn, Donald A.] Univ Washington, Inst Alcohol & Drug Abuse, Seattle, WA 98195 USA.
[Calsyn, Donald A.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Jenkins, Lindsay M.] Recovery Ctr King Cty, Seattle, WA USA.
[Mandler, Raul N.] Natl Inst Drug Abuse, Clin Trials Network, Bethesda, MD USA.
[Liepman, Michael R.] Michigan State Univ, Kalamazoo Ctr Med Studies, Dept Psychiat, Kalamazoo, MI USA.
RP Campbell, BK (reprint author), Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM drbarbaracampbell@earthlink.net
FU NCRR NIH HHS [UL1 RR024140]; NIDA NIH HHS [U10 DA013716, U10 DA013036,
U10 DA013036-08, U10 DA013710, U10 DA013714, U10 DA015831, U10 DA13036,
U10 DA13710, U10 DA13714, U10 DA13716, U10 DA15831]
NR 78
TC 13
Z9 13
U1 1
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS Behav.
PD JAN
PY 2011
VL 15
IS 1
BP 30
EP 44
DI 10.1007/s10461-010-9751-7
PG 15
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 708TM
UT WOS:000286387200005
PM 20652630
ER
PT J
AU Chan, YF
Passetti, LL
Garner, BR
Lloyd, JJ
Dennis, ML
AF Chan, Ya-Fen
Passetti, Lora L.
Garner, Bryan R.
Lloyd, Jacqueline J.
Dennis, Michael L.
TI HIV Risk Behaviors: Risky Sexual Activities and Needle Use Among
Adolescents in Substance Abuse Treatment
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV risk; Sexual risk; Adolescent; Substance use; Mental health
ID PSYCHIATRIC-DISORDERS; PSYCHOLOGICAL DISTRESS; GENDER-DIFFERENCES;
DELINQUENT YOUTH; UNITED-STATES; YOUNG-ADULTS; INFECTION; DRUGS;
COMORBIDITY; PREVALENCE
AB This study estimated prevalence of HIV risk behaviors and its association with substance use and mental health problems among adolescents in treatment. A pooled dataset of 9,519 adolescents admitted to substance abuse treatment programs between 2002 and 2006 was analyzed. HIV risk behaviors, substance use, and mental health problems were assessed at treatment intake. Sixty percent of adolescents were engaged in at least one sexual or needle use risk behavior in the year prior to entering treatment. Sex with multiple partners, sex under the influence of alcohol or drugs, and unprotected sex were the most prevalent HIV risk behaviors. Several gender differences were found for specific types of sexual and needle use behaviors. Adolescents with substance dependence or other comorbid mental health problems were at increased odds for HIV risk. Findings suggest treatment programs may benefit adolescents better by screening them consistently for HIV risk behaviors and incorporating tailored interventions.
C1 [Chan, Ya-Fen; Passetti, Lora L.; Garner, Bryan R.; Dennis, Michael L.] Chestnut Hlth Syst, ML Dennis Lighthouse Inst, Normal, IL 61761 USA.
[Lloyd, Jacqueline J.] Natl Inst Drug Abuse, NIH, Bethesda, MD USA.
RP Chan, YF (reprint author), Chestnut Hlth Syst, ML Dennis Lighthouse Inst, 448 Wylie Dr, Normal, IL 61761 USA.
EM ychan@chestnut.org
FU CSAT SAMHSA HHS [TI13322, TI13344, TI14103, TI14189, TI14196, TI14271,
TI14376, TI15348, TI15421, TI15447, TI15458, TI15461, TI15467, TI15469,
TI15478, TI15481, TI15483, TI15485, TI15489, TI15511, TI15524, TI15562,
TI15577, TI15584, TI15586, TI15670, TI15672, TI15674, TI15678, TI16400,
TI16949, TI16961, TI16992, TI1705, TI17070, TI17119, TI17434, TI18406,
TI3345, TI11894, TI13340, TI17530, TI17484, TI17475, TI17446, TI17433,
TI17334, TI17095, TI17071, TI17046, TI17002, TI16991, TI16984, TI16939,
TI16935, TI16928, TI16915, TI16904, TI16418, TI16414, TI16386, TI15686,
TI15682, TI15677, TI15671, TI15545, TI15527, TI15514, TI15486, TI15479,
TI15475, TI15466, TI15446, TI15433, TI15415, TI15413, TI14355, TI14315,
TI14311, TI14283, TI14272, TI14267, TI14261, TI14254, TI14252, TI14214,
TI14188, TI14090, TI13356, TI13354, TI13323, TI13309, TI13305, TI11888,
TI11871, TI11433, TI11424, TI11422, TI11323, TI11321, TI11892, TI11874,
TI11432, TI11423, TI11324, TI11320, TI11317, TI13308, TI13313]; NIDA NIH
HHS [R37 DA011323]
NR 47
TC 13
Z9 13
U1 2
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS behav.
PD JAN
PY 2011
VL 15
IS 1
BP 114
EP 124
DI 10.1007/s10461-010-9702-3
PG 11
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 708TM
UT WOS:000286387200013
PM 20411413
ER
PT J
AU Nakigozi, G
Makumbi, F
Reynolds, S
Galiwango, R
Kagaayi, J
Nalugoda, F
Ssettuba, A
Sekasanvu, J
Musuuza, J
Serwada, D
Gray, R
Wawer, M
AF Nakigozi, Gertrude
Makumbi, Fredrick
Reynolds, Steven
Galiwango, Ronald
Kagaayi, Joseph
Nalugoda, Fred
Ssettuba, Absalom
Sekasanvu, Joseph
Musuuza, Jackson
Serwada, David
Gray, Ron
Wawer, Maria
TI Non-enrollment for free community HIV care: findings from a
population-based study in Rakai, Uganda
SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
LA English
DT Article
DE HIV; HIV care; enrollment
ID BEHAVIOR
AB Improved understanding of HIV-related health-seeking behavior at a population level is important in informing the design of more effective HIV prevention and care strategies. We assessed the frequency and determinants of failure to seek free HIV care in Rakai, Uganda. HIV-positive participants in a community cohort who accepted VCT were referred for free HIV care (cotrimoxazole prophylaxis, CD4 monitoring, treatment of opportunistic infections, and, when indicated, antiretroviral therapy). We estimated proportion and adjusted Prevalence Risk Ratios (adj. PRR) of non-enrollment into care six months after receipt of VCT using log-binomial regression. About 1145 HIV-positive participants in the Rakai Community Cohort Study accepted VCT and were referred for care. However, 31.5% (361/1145) did not enroll into HIV care six months after referral. Non-enrollment was significantly higher among men (38%) compared to women (29%, p = 0.005). Other factors associated with non-enrollment included: younger age (15-24 years, adj. PRR = 2.22; 95% CI: 1.64, 3.00), living alone (adj. PRR = 2.22; 95% CI: 1.57, 3.15); or in households with 1-2 co-residents (adj. PRR = 1.63; 95% CI: 1.31, 2.03) compared to three or more co-residents, or a CD4 count >250 cells/ul (adj. PRR = 1.81; 95% CI: 1.38, 2.46). Median (IQR) CD4 count was lower among enrolled 388 cells/ul (IQR: 211,589) compared to those not enrolled 509 cells/ul (IQR: 321,754).
About one-third of HIV-positive persons failed to utilize community-based free services. Non-use of services was greatest among men, the young, persons with higher CD4 counts and the more socially isolated, suggesting a need for targeted strategies to enhance service uptake.
C1 [Nakigozi, Gertrude; Galiwango, Ronald; Kagaayi, Joseph; Nalugoda, Fred; Ssettuba, Absalom; Sekasanvu, Joseph; Musuuza, Jackson] Rakai Hlth Sci Program, Kalisizo, Rakai, Uganda.
[Makumbi, Fredrick; Serwada, David] Makerere Univ, Sch Publ Hlth, Kampala, Uganda.
[Reynolds, Steven] NIAID, NIH, Bethesda, MD 20892 USA.
[Gray, Ron; Wawer, Maria] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Nakigozi, G (reprint author), Rakai Hlth Sci Program, Old Bukoba Rd, Kalisizo, Rakai, Uganda.
EM gnakigozi@rhsp.org
FU Intramural NIH HHS [Z99 AI999999]
NR 16
TC 20
Z9 20
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0954-0121
J9 AIDS CARE
JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv
PY 2011
VL 23
IS 6
BP 764
EP 770
DI 10.1080/09540121.2010.525614
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychology, Multidisciplinary; Respiratory System; Social Sciences,
Biomedical
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychology; Respiratory System; Biomedical Social Sciences
GA 764FT
UT WOS:000290615500015
PM 21293989
ER
PT J
AU Malee, KM
Tassiopoulos, K
Huo, YL
Siberry, G
Williams, PL
Hazra, R
Smith, RA
Allison, SM
Garvie, PA
Kammerer, B
Kapetanovic, S
Nichols, S
Van Dyke, R
Seage, GR
Mellins, CA
AF Malee, Kathleen M.
Tassiopoulos, Katherine
Huo, Yanling
Siberry, George
Williams, Paige L.
Hazra, Rohan
Smith, Renee A.
Allison, Susannah M.
Garvie, Patricia A.
Kammerer, Betsy
Kapetanovic, Suad
Nichols, Sharon
Van Dyke, Russell
Seage, George R., III
Mellins, Claude A.
CA Pediat HIV AIDS Cohort Study Team
TI Mental health functioning among children and adolescents with perinatal
HIV infection and perinatal HIV exposure
SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
LA English
DT Article
DE mental health problems; children and adolescents; perinatal HIV
exposure; HIV infection
ID DEPRESSIVE SYMPTOMS; INTELLECTUAL DISABILITY; BEHAVIORAL-PROBLEMS;
PSYCHOPATHOLOGY; DISORDERS; MOTHERS; HIV/AIDS; RISK; PREVALENCE;
PREDICTORS
AB Mental health problems (MHPs) among children with perinatal HIV infection have been described prior to and during the highly active antiretroviral therapy (HAART) era. Yet child, caregiver and socio-demographic factors associated with MHPs are not fully understood. We examined the prevalence of MHPs among older children and adolescents with perinatal HIV exposure, including both perinatally HIV-infected (PHIV+) and perinatally HIV-exposed but uninfected (PHEU) youth. Our aims were to identify the impact of HIV infection by comparing PHIV+ and PHEU youth and to delineate risk factors associated with MHPs, in order to inform development of appropriate prevention and intervention strategies. Youth and their caregivers were interviewed with the Behavior Assessment System for Children, 2nd edition (BASC-2) to estimate rates of at-risk and clinically significant MHPs, including caregiver-reported behavioral problems and youth-reported emotional problems. The prevalence of MHPs at the time of study entry was calculated for the group overall, as well as by HIV status and by demographic, child health, and caregiver characteristics. Logistic regression models were used to identify factors associated with youth MHPs. Among 416 youth enrolled between March 2007 and July 2009 (295 PHIV+, 121 PHEU), the overall prevalence of MHPs at entry was 29% and greater than expected based on recent national surveys of the general population. MHPs were more likely among PHEU than among PHIV+ children (38% versus 25%, p < 0.01). Factors associated with higher odds of MHPs at p < 0.10 included caregiver characteristics (psychiatric disorder, limit-setting problems, health-related functional limitations) and child characteristics (younger age and lower IQ). These findings suggest that PHEU children are at high risk for MHPs, yet current models of care for these youth may not support early diagnosis and treatment. Family-based prevention and intervention programs for HIV affected youth and their caregivers may minimize long-term consequences of MHPs.
C1 [Malee, Kathleen M.] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA.
[Tassiopoulos, Katherine; Seage, George R., III] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Huo, Yanling] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA.
[Siberry, George; Hazra, Rohan] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
[Williams, Paige L.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
[Smith, Renee A.] Univ Illinois, Dept Pediat, Chicago, IL USA.
[Allison, Susannah M.; Kapetanovic, Suad] NIMH, Ctr Mental Hlth Res AIDS, Bethesda, MD 20892 USA.
[Garvie, Patricia A.] St Jude Childrens Hosp, Memphis, TN 38105 USA.
[Kammerer, Betsy] Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA.
[Kammerer, Betsy] Childrens Hosp, Dept Otolaryngol & Commun Disorders, Boston, MA 02115 USA.
[Nichols, Sharon] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
[Van Dyke, Russell] Tulane Univ, Hlth Sci Ctr, Dept Infect Dis, New Orleans, LA 70118 USA.
[Mellins, Claude A.] Columbia Univ, Dept Psychiat & Sociomed Sci, New York, NY USA.
RP Malee, KM (reprint author), Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA.
EM kmalee@childrensmemorial.org
FU NICHD NIH HHS [U01 HD052102-04, U01 HD052102, U01 HD052104, U01
HD052104-01]
NR 59
TC 32
Z9 32
U1 4
U2 11
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0954-0121
J9 AIDS CARE
JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv
PY 2011
VL 23
IS 12
BP 1533
EP 1544
DI 10.1080/09540121.2011.575120
PG 12
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychology, Multidisciplinary; Respiratory System; Social Sciences,
Biomedical
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychology; Respiratory System; Biomedical Social Sciences
GA 881KA
UT WOS:000299481400002
PM 21702707
ER
PT J
AU Larder, BA
Revell, A
Mican, JM
Agan, BK
Harris, M
Torti, C
Izzo, I
Metcalf, JA
Rivera-Goba, M
Marconi, VC
Wang, DC
Coe, D
Gazzard, B
Montaner, J
Lane, HC
AF Larder, Brendan A.
Revell, Andrew
Mican, JoAnn M.
Agan, Brian K.
Harris, Marianne
Torti, Carlo
Izzo, Ilaria
Metcalf, Julia A.
Rivera-Goba, Migdalia
Marconi, Vincent C.
Wang, Dechao
Coe, Daniel
Gazzard, Brian
Montaner, Julio
Lane, H. Clifford
TI Clinical Evaluation of the Potential Utility of Computational Modeling
as an HIV Treatment Selection Tool by Physicians with Considerable HIV
Experience
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID PREDICT VIROLOGICAL RESPONSE; SOCIETY-USA PANEL; DRUG-RESISTANCE;
ANTIRETROVIRAL TREATMENT; VIRTUAL PHENOTYPE; GENOTYPE; THERAPY;
RECOMMENDATIONS; INFECTION; SYSTEMS
AB The HIV Resistance Response Database Initiative (RDI), which comprises a small research team in the United Kingdom and collaborating clinical centers in more than 15 countries, has used antiretroviral treatment and response data from thousands of patients around the world to develop computational models that are highly predictive of virologic response. The potential utility of such models as a tool for assisting treatment selection was assessed in two clinical pilot studies: a prospective study in Canada and Italy, which was terminated early because of the availability of new drugs not covered by the system, and a retrospective study in the United States. For these studies, a Web-based user interface was constructed to provide access to the models. Participating physicians entered baseline data for cases of treatment failure and then registered their treatment intention. They then received a report listing the five alternative regimens that the models predicted would be most effective plus their own selection, ranked in order of predicted virologic response. The physicians then entered their final treatment decision. Twenty-three physicians entered 114 cases (75 unique cases with 39 entered twice by different physicians). Overall, 33% of treatment decisions were changed following review of the report. The final treatment decisions and the best of the RDI alternatives were predicted to produce greater virologic responses and involve fewer drugs than the original selections. Most physicians found the system easy to use and understand. All but one indicated they would use the system if it were available, particularly for highly treatment-experienced cases with challenging resistance profiles. Despite limitations, the first clinical evaluation of this approach by physicians with substantial HIV-experience suggests that it has the potential to deliver clinical and economic benefits.
C1 [Larder, Brendan A.; Revell, Andrew; Wang, Dechao; Coe, Daniel] HIV Resistance RDI, London, England.
[Mican, JoAnn M.; Metcalf, Julia A.; Lane, H. Clifford] NIAID, Bethesda, MD 20892 USA.
[Agan, Brian K.; Marconi, Vincent C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Harris, Marianne; Montaner, Julio] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada.
[Torti, Carlo; Izzo, Ilaria] Univ Brescia, Brescia, Italy.
[Rivera-Goba, Migdalia] NIH, Ctr Clin, Bethesda, MD 20892 USA.
[Gazzard, Brian] Chelsea & Westminster Hosp, London, England.
RP Revell, A (reprint author), RDI, 14 Union Sq, London N1 7DH, England.
EM andrewrevell@hivrdi.org
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669
FU National Cancer Institute, National Institutes of Health
[HHSN261200800001E]; National Institute of Allergy and Infectious
Diseases; Infectious Disease Clinical Research Program (IDCRP), a
Department of Defense (DoD) [IDCRP-000-15]; National Institute of
Allergy and Infectious Diseases, National Institutes of Health (NIH)
[Y1-AI-5072]
FX This project has been funded in whole or in part with federal funds from
the National Cancer Institute, National Institutes of Health, under
Contract No. HHSN261200800001E. This research was supported in whole or
in part by the National Institute of Allergy and Infectious Diseases.;
Support for a portion of this work (IDCRP-000-15) was provided by the
Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) program executed through the Uniformed Services University
of the Health Sciences. This project has been funded in whole, or in
part, with federal funds from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH), under
Inter-Agency Agreement Y1-AI-5072.
NR 21
TC 15
Z9 15
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD JAN
PY 2011
VL 25
IS 1
BP 29
EP 36
DI 10.1089/apc.2010.0254
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 704PW
UT WOS:000286065900005
PM 21214377
ER
PT J
AU Veronese, F
Anton, P
Fletcher, CV
DeGruttola, V
McGowan, I
Becker, S
Zwerski, S
Burns, D
AF Veronese, Fulvia
Anton, Peter
Fletcher, Courtney V.
DeGruttola, Victor
McGowan, Ian
Becker, Stephen
Zwerski, Sheryl
Burns, David
CA Workshop Organizing Comm
TI Implications of HIV PrEP Trials Results
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID INFECTION; IDENTIFICATION; PREVENTION
AB Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and infectious Diseases (NIAID), National Institutes of Health (NTH), and the Bill and Melinda Gates Foundation (BMGF) was held on 'January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop.
C1 [Veronese, Fulvia; Zwerski, Sheryl; Burns, David] NIAID, PSP, DAIDS, NIH, Bethesda, MD 20892 USA.
[Anton, Peter] Univ Calif Los Angeles, Ctr HIV Prevent Res, David Geffen Sch Med, Los Angeles, CA USA.
[Fletcher, Courtney V.] Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE USA.
[DeGruttola, Victor] Harvard Univ, Harvard Sch Publ Hlth, Boston, MA 02115 USA.
[McGowan, Ian] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Magee Womens Res Inst, Pittsburgh, PA USA.
[Becker, Stephen] BMGF, Global Hlth HIV, Seattle, WA USA.
RP Veronese, F (reprint author), NIAID, PSP, DAIDS, NIH, 5th Floor,Room 5122,6700B Rockledge Dr, Bethesda, MD 20892 USA.
EM veronesf@niaid.nih.gov
RI Hendrix, Craig/G-4182-2014
OI Hendrix, Craig/0000-0002-5696-8665
FU BMGF; DAIDS; NIAID; NTH; B L Seamon (BLS) Corporation
FX The authors wish to thank the BMGF and DAIDS, NIAID, NTH [via its
contract for conference planning and support services with B L Seamon
(BLS) Corporation] for sponsoring this consultation. The authors also
wish to extend their thanks to the organizing committee-Dr. Stephen
Becker, BMGF (external member); and Drs. Paul Black, Roberta Black,
David Burns, Diana Finzi, Jim Turpin, Fulvia Veronese, and Mrs. Sheryl
Zwerski [internal (NIH/NIAID/DAIDS) members]-for their critical
contributions in developing the workshop's objectives and agenda.
Furthermore, we wish to thank the facilitators of the breakout sessions,
Drs. Hoosen Coovadia (University of KwaZulu-Natal) and Veronica Miller
(George Washington University), and the rapporteurs, Drs. Victor
DeGruttola (Harvard School of Public Health) and Ian McGowan
(Magee-Women's Research Institute/University of Pittsburgh School of
Medicine) for their outstanding effort in highlighting important issues
to consider for the field. Lastly, we wish to thank Ms. Jennifer Coulter
and Mrs. Jean Morrow, Henry M. Jackson Foundation (HJF), for their
assistance in all aspects of the workshop (in conjunction with BLS), and
Mr. Lester Freeman (HJF) for his meticulous editorial assistance and
contributions to the workshop. The authors are indeed grateful to all
who participated in and supported this workshop in an effort to advance
the field.
NR 17
TC 11
Z9 13
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD JAN
PY 2011
VL 27
IS 1
BP 81
EP 90
DI 10.1089/aid.2010.0226
PG 10
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 708JL
UT WOS:000286358000013
PM 20969483
ER
PT J
AU Sanders-Beer, BE
Spano, YY
Golighty, D
Lara, A
Hebblewaite, D
Nieves-Duran, L
Rhodes, L
Mansfield, KG
AF Sanders-Beer, Brigitte E.
Spano, Yvette Y.
Golighty, Dawn
Lara, Abigail
Hebblewaite, Diane
Nieves-Duran, Lourdes
Rhodes, Lowrey
Mansfield, Keith G.
TI Clinical monitoring and correlates of nephropathy in SIV-infected
macaques during high-dose antiretroviral therapy
SO AIDS RESEARCH AND THERAPY
LA English
DT Article
AB Background: In many preclinical AIDS research studies, antiretroviral therapy (ART) is administered to experimentally simian immunodeficiency (SIV)-infected rhesus macaques for reduction of viral load to undetectable levels. Prolonged treatment of macaques with a high dose of PMPA (9-[2-(r)-(phosphonomethoxy) propyl] adenine or tenofovir; 30 mg/kg of body weight subcutaneously once daily) can result in proximal renal tubular dysfunction, a Fanconi-like syndrome characterized by glucosuria, aminoaciduria, hypophosphatemia, and bone pathology. In contrast, chronic administration of a low dose of PMPA (10 mg/kg subcutaneously once daily) starting at birth does not seem to be associated with any adverse health effects within 3 years of treatment. In contrast to PMPA, limited information on systemic toxicity in rhesus monkeys is available for FTC (5-fluoro-1-(2R,5S)-[2( hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine; emtricitabine) and stavudine (d4T).
Results: In this study, the clinical and biochemical correlates of tubular nephrosis in SIV-infected rhesus macaques associated with systemic administration of high-dose ART consisting of the three nucleoside analog inhibitors PMPA, FTC, and d4T were investigated. It was found that acute renal failure was uncommon (7.1% of treated animals) and that morphologic evidence of nephropathy, which persisted for more than 300 days following discontinuation of the drug cocktail, was more frequent (52.4% of treated animals). While parameters from single time points lacked predictive value, biochemical alterations in Blood Urea Nitrogen (BUN) and phosphorus were frequently identified longitudinally in the blood of ART-treated animals that developed evidence of nephropathy, and these longitudinal changes correlated with disease severity.
Conclusions: Recommendations are proposed to limit the impact of drug-induced renal disease in future SIV macaque studies.
C1 [Sanders-Beer, Brigitte E.; Golighty, Dawn; Lara, Abigail; Hebblewaite, Diane; Nieves-Duran, Lourdes; Rhodes, Lowrey] So Res Inst, Frederick, MD USA.
[Mansfield, Keith G.] Harvard Univ, Sch Med, New England Primate Res Ctr, Southborough, MA 01772 USA.
[Sanders-Beer, Brigitte E.] BIOQUAL Inc, Rockville, MD 20850 USA.
[Spano, Yvette Y.] NIAID, Vaccine Res Program, Div Aids, NIH, Bethesda, MD 20817 USA.
RP Sanders-Beer, BE (reprint author), So Res Inst, Frederick, MD USA.
EM bsanders@bioqual.com
FU NIH/NIAID [N01-AI-15451]
FX This work was supported by NIH/NIAID contract N01-AI-15451. PMPA and FTC
were kindly provided by Gilead Corporation, and Zerit (R) was a gift
from the AIDS Research and Reference Reagent Program, NIAID, NIH. We
would also like to thank Dr. Ron Desrosiers for donating the SIVmac239
challenge stock, and Audra Hachey for tissue processing.
NR 21
TC 4
Z9 4
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-6405
J9 AIDS RES THER
JI Aids Res. Ther.
PY 2011
VL 8
AR 3
DI 10.1186/1742-6405-8-3
PG 11
WC Infectious Diseases
SC Infectious Diseases
GA V27LK
UT WOS:000208614500003
PM 21255437
ER
PT J
AU Warren, KR
Hewitt, BG
Thomas, JD
AF Warren, Kenneth R.
Hewitt, Brenda G.
Thomas, Jennifer D.
TI Fetal Alcohol Spectrum Disorders Research Challenges and Opportunities
SO ALCOHOL RESEARCH & HEALTH
LA English
DT Article
DE Fetal alcohol spectrum disorders; fetal alcohol syndrome; fetal alcohol
effects; maternal alcohol consumption; prenatal alcohol exposure;
pregnancy; alcohol related birth defects; developmental disorders;
diagnosis; research; alcohol-related neurodevelopmental disorder
ID ACID ETHYL-ESTERS; PRENATAL ALCOHOL; BRIEF INTERVENTION; BIRTH-DEFECTS;
UNITED-STATES; ETHANOL; PREGNANCY; EXPOSURE; PREVALENCE; DIAGNOSIS
AB The adverse effects of prenatal alcohol consumption have long been known; however, a formal description and clinical diagnosis of these effects was not introduced until 1973. Since then, the distinction of the wide range of effects that can be induced by prenatal alcohol exposure, and, consequently, the terminology to describe these effects has continued to evolve. Although much progress has been made in understanding the consequences of prenatal alcohol exposure, challenges still remain in properly identifying all affected individuals as well as their individual patterns of alcohol-induced deficits. Also, as the large numbers of women who continue to drink during pregnancy indicate, prevention efforts still require further refinement to enhance their effectiveness. In addition, the mechanisms underlying alcohol-induced damage have not yet been fully elucidated; as knowledge of the mechanisms underlying alcohol-induced deficits continues to grow, the possibility of minimizing potential harm by intervening during prenatal alcohol exposure is enhanced. Finally, researchers are exploring additional ways to improve or fully restore behavioral and cognitive functions disrupted by prenatal alcohol exposure by treating the individuals with fetal alcohol spectrum disorders, thereby reducing the heavy burden for affected individuals and their families.
C1 [Warren, Kenneth R.; Hewitt, Brenda G.] NIAAA, Bethesda, MD USA.
[Thomas, Jennifer D.] San Diego State Univ, Dept Psychol, Ctr Behav Teratol, San Diego, CA 92182 USA.
RP Warren, KR (reprint author), NIAAA, Bethesda, MD USA.
FU NIAAA NIH HHS [AA-014811, R01 AA012446, AA-012446, U24 AA014811]
NR 41
TC 25
Z9 25
U1 2
U2 9
PU NATL INST ALCOHOL ABUSE ALCOHOLISM
PI ROCKVILLE
PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA
SN 1535-7414
J9 ALCOHOL RES HEALTH
JI Alcohol Res. Health
PY 2011
VL 34
IS 1
BP 4
EP 14
PG 11
WC Substance Abuse
SC Substance Abuse
GA 783XJ
UT WOS:000292117900001
PM 23580035
ER
PT J
AU Chen, WJA
Maier, SE
AF Chen, Wei-Jung A.
Maier, Susan E.
TI COMBINATION DRUG USE AND RISK FOR FETAL HARM
SO ALCOHOL RESEARCH & HEALTH
LA English
DT Editorial Material
ID EPIDEMIOLOGIC ANALYSIS; COOCCURRING ALCOHOL; CONCURRENT USE; COCAINE;
EXPOSURE; COCAETHYLENE; DISORDERS; RATS
C1 [Chen, Wei-Jung A.] Texas A&M Hlth Sci Ctr, Coll Med, Dept Neurosci & Expt Therapeut, College Stn, TX USA.
[Maier, Susan E.] NIAID, Off Initiat Dev, Bethesda, MD 20892 USA.
RP Chen, WJA (reprint author), Texas A&M Hlth Sci Ctr, Coll Med, Dept Neurosci & Expt Therapeut, College Stn, TX USA.
NR 19
TC 1
Z9 1
U1 0
U2 0
PU NATL INST ALCOHOL ABUSE ALCOHOLISM
PI ROCKVILLE
PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA
SN 1535-7414
J9 ALCOHOL RES HEALTH
JI Alcohol Res. Health
PY 2011
VL 34
IS 1
BP 27
EP 28
PG 2
WC Substance Abuse
SC Substance Abuse
GA 783XJ
UT WOS:000292117900003
PM 23580037
ER
PT J
AU Dawson, DA
AF Dawson, Deborah A.
TI Defining Risk Drinking
SO ALCOHOL RESEARCH & HEALTH
LA English
DT Article
DE Alcohol consumption; alcohol use disorder; alcohol-related harm; alcohol
and other drug use (AOD) use harm reduction; harm minimization;
prevention of harm from AOD use; problematic AOD use; prevention of
problematic AOD use; AOD induced risk; attributable risk; risk
thresholds; morbidity; AOD risk mortality; AOD risk injury; standard
drink; amount of AOD use; responsible AOD use
ID ALCOHOL-USE DISORDERS; IDENTIFICATION TEST AUDIT; SINGLE SCREENING
QUESTION; ANALYSIS-PROJECT ERCAAP; PRIMARY-CARE VALIDATION; PER-CAPITA
CONSUMPTION; US GENERAL-POPULATION; BINGE DRINKING; EMERGENCY-ROOM;
CASE-CROSSOVER
AB Many efforts to prevent alcohol-related harm are aimed at reducing risk drinking. This article outlines the many conceptual and methodological challenges to defining risk drinking. It summarizes recent evidence regarding associations of various aspects of alcohol consumption with chronic and acute alcohol-related harms, including mortality, morbidity, injury, and alcohol use disorders, and summarizes the study designs most appropriate to defining risk thresholds for these types of harm. In addition, it presents an international overview of low-risk drinking guidelines from more than 20 countries, illustrating the wide range of interpretations of the scientific evidence related to risk drinking. This article also explores the impact of drink size on defining risk drinking and describes variation in what is considered to be a standard drink across populations. Actual and standard drink sizes differ in the United States, and this discrepancy affects definitions of risk drinking and prevention efforts.
C1 [Dawson, Deborah A.] NIAAA, Lab Epidemiol & Biometry, NIH, Bethesda, MD USA.
FU Intramural NIH HHS
NR 119
TC 28
Z9 29
U1 6
U2 17
PU NATL INST ALCOHOL ABUSE ALCOHOLISM
PI ROCKVILLE
PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA
SN 1535-7414
J9 ALCOHOL RES HEALTH
JI Alcohol Res. Health
PY 2011
VL 34
IS 2
BP 144
EP 156
PG 13
WC Substance Abuse
SC Substance Abuse
GA 865IM
UT WOS:000298304600002
PM 22330212
ER
EF