FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Sales, KU
   Friis, S
   Abusleme, L
   Moutsopoulos, NM
   Bugge, TH
AF Sales, K. U.
   Friis, S.
   Abusleme, L.
   Moutsopoulos, N. M.
   Bugge, T. H.
TI Matriptase promotes inflammatory cell accumulation and progression of
   established epidermal tumors
SO ONCOGENE
LA English
DT Article
ID SERINE-PROTEASE MATRIPTASE; HEPATOCYTE GROWTH-FACTOR; FACTOR ACTIVATOR
   INHIBITOR-2; MOUSE SKIN CARCINOGENESIS; CLINICOPATHOLOGICAL PARAMETERS;
   PROSTATE-CANCER; GENE-EXPRESSION; OVARIAN-CANCER; CARCINOMA; RAS
AB Deregulation of matriptase is a consistent feature of human epithelial cancers and correlates with poor disease outcome. We have previously shown that matriptase promotes multi-stage squamous cell carcinogenesis in transgenic mice through dual activation of pro-hepatocyte growth factor-cMet-Akt-mTor proliferation/survival signaling and PAR-2-Gai-NF kappa B inflammatory signaling. Matriptase was congenitally and constitutively deregulated in our prior studies, and therefore it was unclear if aberrant matriptase signaling supports only initiation of tumor formation or if it is also critical for the progression of established tumors. To determine this, we here have generated triple-transgenic mice with constitutive deregulation of matriptase and simultaneous inducible expression of the cognate matriptase inhibitor, hepatocyte growth factor inhibitor (HAI)-2. As expected, constitutive expression of HAI-2 suppressed the formation of matriptase-dependent tumors in 7,12-Dimethylbenz(a)anthracene-treated mouse skin. Interestingly, however, the induction of HAI-2 expression in already established tumors markedly impaired malignant progression and caused regression of individual tumors. Tumor regression correlated with reduced accumulation of tumor-associated inflammatory cells, likely caused by diminished expression of pro-tumorigenic inflammatory cytokines. The data suggest that matriptase-dependent signaling may be a therapeutic target for both squamous cell carcinoma chemoprevention and for the treatment of established tumors.
C1 [Sales, K. U.; Friis, S.; Abusleme, L.; Moutsopoulos, N. M.; Bugge, T. H.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
   [Sales, K. U.] Natl Inst Dent & Craniofacial Res, Clin Res Core, NIH, Bethesda, MD 20892 USA.
   [Sales, K. U.] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Cell & Mol Biol, BR-14049 Ribeirao Preto, Brazil.
   [Friis, S.] Univ Copenhagen, Fac Hlth & Med Sci, Dept Cellular & Mol Med, Copenhagen, Denmark.
RP Bugge, TH (reprint author), Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Room 211,30 Convent Dr, Bethesda, MD 20892 USA.
EM thomas.bugge@nih.gov
FU NIDCR Intramural Research Program; Sao Paulo Research Foundation
   [2014/14311-0]; Harboe Foundation; Lundbeck Foundation;  [17.12.1981]
FX We thank Dr Mary Jo Danton and Dr J Silvio Gutkind for critically
   reviewing this manuscript. We also thank Andrew Cho and Dr Ashok
   Kulkarni, NIDCR Gene Targeting Facility, for generation of transgenic
   mice. Histology was performed by Histoserv, Inc., Germantown, MD, USA.
   The study was supported by the NIDCR Intramural Research Program (THB),
   Sao Paulo Research Foundation 2014/14311-0 (KUS), The Harboe Foundation,
   The Foundation of 17.12.1981 and the Lundbeck Foundation (SF).
NR 47
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U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9232
EI 1476-5594
J9 ONCOGENE
JI Oncogene
PD AUG 27
PY 2015
VL 34
IS 35
BP 4664
EP 4672
DI 10.1038/onc.2014.391
PG 9
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
   Heredity
GA CP9BS
UT WOS:000360189300012
PM 25486433
ER

PT J
AU Bartz, SK
   Karaviti, LP
   Brandt, ML
   Lopez, ME
   Masand, P
   Devaraj, S
   Hicks, J
   Anderson, L
   Lodish, M
   Keil, M
   Stratakis, CA
AF Bartz, Sara K.
   Karaviti, Lefkothea P.
   Brandt, Mary L.
   Lopez, Monica E.
   Masand, Prakash
   Devaraj, Sridevi
   Hicks, John
   Anderson, Lauren
   Lodish, Maya
   Keil, Meg
   Stratakis, Constantine A.
TI Residual manifestations of hypercortisolemia following surgical
   treatment in a patient with Cushing syndrome
SO INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Cushing syndrome; Obesity; PPNAD; Primary pigmented nodular
   adrenocortical disease
ID NODULAR ADRENOCORTICAL DISEASE; CARNEY COMPLEX; DIAGNOSIS; PATHOGENESIS;
   HYPERTENSION; CHILDREN; QUALITY; COHORT
AB Context: Cushing Syndrome is difficult to diagnose, and the comorbidities and persistent late effects of hypercortisolemia after treatment of the primary disease are challenging for the patient and the endocrinologist.
   Objective: To report the case of a girl with obesity and hypertension, ultimately diagnosed with Cushing syndrome due to primary pigmented nodular adrenocortical disease. In this case, the complications of hypercortisolism persisted short term despite surgical intervention.
   Patient: A 4 year old morbidly obese African-American girl with developmental delay presented with hypertensive emergency in the ER and 18-month history of progressive weight gain. Her previous history included premature adrenarche, hypertension, seizures and a random high cortisol with suppressed ACTH. She was subsequently stabilized, and a diagnostic work-up persistently demonstrated elevated cortisol and suppressed ACTH. An abdominal MRI showed bilateral adrenal multinodular disease, consistent with multinodular hyperplasia of the adrenal glands. Based on these findings the patient underwent a bilateral adrenalectomy, which confirmed primary pigmented nodular adrenocortical disease. The patient had a complicated, protracted post-operative course requiring adjustment of therapy for persistent hypertension. Two months after surgery, she was readmitted to the Emergency Department with hyperpyrexia and hypertension and succumbed to the complications of sepsis.
   Conclusions and outcome: This case highlights the significant diagnostic and therapeutic challenges in treating children with Cushing syndrome. Resolution of the source of hypercortisolemia does not imply regression of hypertension or recovery of the immune system. Although the child underwent bilateral adrenalectomy, persistent consequences of prolonged severe hypercortisolism contributed to her death two months later.
C1 [Bartz, Sara K.; Karaviti, Lefkothea P.] Texas Childrens Hosp, Dept Pediat Endocrinol & Metab, Houston, TX 77030 USA.
   [Brandt, Mary L.; Lopez, Monica E.] Texas Childrens Hosp, Baylor Coll Med, Michael E DeBakey Dept Surg, Div Pediat Surg, Houston, TX 77030 USA.
   [Masand, Prakash] Texas Childrens Hosp, Dept Radiol, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Texas Childrens Hosp, Clin Chem & POCT, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Clin Chem & POCT, Houston, TX 77030 USA.
   [Hicks, John] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA.
   [Hicks, John; Anderson, Lauren] Baylor Coll Med, Houston, TX 77030 USA.
   [Lodish, Maya; Keil, Meg; Stratakis, Constantine A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Houston, TX USA.
RP Bartz, SK (reprint author), Texas Childrens Hosp, Dept Pediat Endocrinol & Metab, Houston, TX 77030 USA.
EM klinepet@bcm.edu
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U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1687-9848
EI 1687-9856
J9 INT J PEDIATR ENDOCR
JI Int. J. Pediatr. Endocrinol.
PD AUG 26
PY 2015
AR UNSP 19
DI 10.1186/s13633-015-0014-2
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CU6PE
UT WOS:000363653800002
PM 26322079
ER

PT J
AU Silson, EH
   Chan, AWY
   Reynolds, RC
   Kravitz, DJ
   Baker, CI
AF Silson, Edward Harry
   Chan, Annie Wai-Yiu
   Reynolds, Richard Craig
   Kravitz, Dwight Jacob
   Baker, Chris Ian
TI A Retinotopic Basis for the Division of High-Level Scene Processing
   between Lateral and Ventral Human Occipitotemporal Cortex
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE hierarchy; retinotopy
ID HUMAN VISUAL-CORTEX; PARAHIPPOCAMPAL PLACE AREA; OCCIPITAL COMPLEX;
   INFEROTEMPORAL CORTEX; CORTICAL CONNECTIONS; OBJECT AREAS; ORGANIZATION;
   MACAQUE; REPRESENTATIONS; PERCEPTION
AB In humans, there is a repeated category-selective organization across the lateral and ventral surfaces of the occipitotemporal cortex. This apparent redundancy is often explained as a feedforward hierarchy, with processing within lateral areas preceding the processing within ventral areas. Here, we tested the alternative hypothesis that this structure better reflects distinct high-level representations of the upper (ventral surface) and lower (lateral surface) contralateral quadrants of the visual field, consistent with anatomical projections from early visual areas to these surfaces in monkey. Using complex natural scenes, we provide converging evidence from three independent functional imaging and behavioral studies. First, population receptive field mapping revealed strong biases for the contralateral upper and lower quadrant within the ventral and lateral scene-selective regions, respectively. Second, these same biases were observed in the position information available both in the magnitude and multivoxel response across these areas. Third, behavioral judgments of a scene property strongly represented within the ventral scene-selective area (open/closed), but not another equally salient property (manmade/natural), were more accurate in the upper than the lower field. Such differential representation of visual space poses a substantial challenge to the idea of a strictly hierarchical organization between lateral and ventral scene-selective regions. Moreover, such retinotopic biases seem to extend beyond these regions throughout both surfaces. Thus, the large-scale organization of high-level extrastriate cortex likely reflects the need for both specialized representations of particular categories and constraints from the structure of early vision.
C1 [Silson, Edward Harry; Chan, Annie Wai-Yiu; Kravitz, Dwight Jacob; Baker, Chris Ian] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
   [Reynolds, Richard Craig] NIMH, Sci & Stat Comp Core, Bethesda, MD 20892 USA.
   [Chan, Annie Wai-Yiu] Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA.
   [Kravitz, Dwight Jacob] George Washington Univ, Dept Psychol, Washington, DC 20052 USA.
RP Silson, EH (reprint author), NIMH, Bldg 10,Room 3N228, Bethesda, MD 20892 USA.
EM ed.silson@nih.gov
OI Baker, Chris/0000-0001-6861-8964
FU Intramural Research Program of the National Institutes of
   Health-National Institute of Mental Health Clinical Study Protocol
   [93-M-0170, NCT00001360]
FX This work was supported by the Intramural Research Program of the
   National Institutes of Health-National Institute of Mental Health
   Clinical Study Protocol 93-M-0170, NCT00001360. We thank Sean Marrett,
   Iris Groen, Adam Steel, Marcie King, and Aaron Trefler for helpful
   comments.
NR 55
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U1 3
U2 4
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 26
PY 2015
VL 35
IS 34
BP 11921
EP 11935
DI 10.1523/JNEUROSCI.0137-15.2015
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA CT0QR
UT WOS:000362501900015
PM 26311774
ER

PT J
AU Ampofo, WK
   Azziz-Baumgartner, E
   Bashir, U
   Cox, NJ
   Fasce, R
   Giovanni, M
   Grohmann, G
   Huang, S
   Katz, J
   Mironenko, A
   MokhtariAzad, T
   Sasono, PM
   Rahman, M
   Sawanpanyalert, P
   Siqueira, M
   Waddell, AL
   Waiboci, L
   Wood, J
   Zhang, WQ
   Ziegler, T
AF Ampofo, William K.
   Azziz-Baumgartner, Eduardo
   Bashir, Uzma
   Cox, Nancy J.
   Fasce, Rodrigo
   Giovanni, Maria
   Grohmann, Gary
   Huang, Sue
   Katz, Jackie
   Mironenko, Alla
   MokhtariAzad, Talat
   Sasono, Pretty Multihartina
   Rahman, Mahmudur
   Sawanpanyalert, Pathom
   Siqueira, Marilda
   Waddell, Anthony L.
   Waiboci, Lillian
   Wood, John
   Zhang, Wenqing
   Ziegler, Thedi
CA WHO Writing Grp
TI Strengthening the influenza vaccine virus selection and development
   process Report of the 3rd WHO Informal Consultation for Improving
   Influenza Vaccine Virus Selection held at WHO headquarters, Geneva,
   Switzerland, 1-3 April 2014
SO VACCINE
LA English
DT Article
DE Influenza vaccine viruses; Vaccine virus selection; WHO recommendations
ID SEASONALITY
AB Despite long-recognized challenges and constraints associated with their updating and manufacture, influenza vaccines remain at the heart of public health preparedness and response efforts against both seasonal and potentially pandemic influenza viruses.
   Globally coordinated virological and epidemiological surveillance is the foundation of the influenza vaccine virus selection and development process. Although national influenza surveillance and reporting capabilities are being strengthened and expanded, sustaining and building upon recent gains has become a major challenge.
   Strengthening the vaccine virus selection process additionally requires the continuation of initiatives to improve the timeliness and representativeness of influenza viruses shared by countries for detailed analysis by the WHO Global Influenza Surveillance and Response System (GISRS).
   Efforts are also continuing at the national, regional, and global levels to better understand the dynamics of influenza transmission in both temperate and tropical regions. Improved understanding of the degree of influenza seasonality in tropical countries of the world should allow for the strengthening of national vaccination policies and use of the most appropriate available vaccines.
   There remain a number of limitations and difficulties associated with the use of HAI assays for the antigenic characterization and selection of influenza vaccine viruses by WHOCCs. Current approaches to improving the situation include the more-optimal use of HAI and other assays; improved understanding of the data produced by neutralization assays; and increased standardization of serological testing methods.
   A number of new technologies and associated tools have the potential to revolutionize influenza surveillance and response activities. These include the increasingly routine use of whole genome next-generation sequencing and other high-throughput approaches. Such approaches could not only become key elements in outbreak investigations but could drive a new surveillance paradigm. However, despite the advances made, significant challenges will need to be addressed before next-generation technologies become routine, particularly in low-resource settings.
   Emerging approaches and techniques such as synthetic genomics, systems genetics, systems biology and mathematical modelling are capable of generating potentially huge volumes of highly complex and diverse datasets. Harnessing the currently theoretical benefits of such bioinformatics ("big data") concepts for the influenza vaccine virus selection and development process will depend upon further advances in data generation, integration, analysis and dissemination.
   Over the last decade, growing awareness of influenza as an important global public health issue has been coupled to ever-increasing demands from the global community for more-equitable access to effective and affordable influenza vaccines. The current influenza vaccine landscape continues to be dominated by egg-based inactivated and live attenuated vaccines, with a small number of cell-based and recombinant vaccines. Successfully completing each step in the annual influenza vaccine manufacturing cycle will continue to rely upon timely and regular communication between the WHO GISRS, manufacturers and regulatory authorities.
   While the pipeline of influenza vaccines appears to be moving towards a variety of niche products in the near term, it is apparent that the ultimate aim remains the development of effective "universal" influenza vaccines that offer longer-lasting immunity against a broad range of influenza A subtypes. (C) 2015 The Authors. Published by Elsevier Ltd.
C1 [Ampofo, William K.] Noguchi Mem Inst Med Res, Accra, Ghana.
   [Azziz-Baumgartner, Eduardo; Cox, Nancy J.; Katz, Jackie] Ctr Dis Control & Prevent CDC, Atlanta, GA USA.
   [Bashir, Uzma] NIH, Islamabad, Pakistan.
   [Fasce, Rodrigo] Natl Influenza Ctr, Publ Hlth Inst Chile, Santiago, Chile.
   [Giovanni, Maria] NIH, Bethesda, MD 20892 USA.
   [Grohmann, Gary] Therapeut Goods Adm, Symonston, Australia.
   [Huang, Sue] Natl Influenza Ctr, Upper Hutt, New Zealand.
   [Mironenko, Alla] Reference Influenza Lab, Kiev, Ukraine.
   [MokhtariAzad, Talat] Natl Influenza Ctr, Tehran, Iran.
   [Sasono, Pretty Multihartina] Natl Inst Hlth Res & Dev, Jakarta, Indonesia.
   [Rahman, Mahmudur] Inst Epidemiol, Dis Control & Res, Dhaka, Bangladesh.
   [Sawanpanyalert, Pathom] Natl Inst Hlth, Bangkok, Thailand.
   [Siqueira, Marilda] Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil.
   [Waiboci, Lillian] CDC Kenya, Nairobi, Kenya.
   [Wood, John] Formerly Natl Inst Biol Stand & Control NIBSC, Potters Bar, Herts, England.
   [Zhang, Wenqing] World Hlth Org, Geneva, Switzerland.
   [Ziegler, Thedi] Natl Influenza Ctr, Helsinki, Finland.
RP Zhang, WQ (reprint author), World Hlth Org, Geneva, Switzerland.
EM GISRS-WHOHQ@who.int
OI Laurie, Karen/0000-0001-5186-8342
FU World Health Organization [001]
NR 12
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U1 4
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD AUG 26
PY 2015
VL 33
IS 36
BP 4368
EP 4382
DI 10.1016/j.vaccine.2015.06.090
PG 15
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CQ8OK
UT WOS:000360867500003
PM 26148877
ER

PT J
AU Tyagi, RK
   Garg, NK
   Jadon, R
   Sahu, T
   Katare, OP
   Dalai, SK
   Awasthi, A
   Marepally, SK
AF Tyagi, Rajeev K.
   Garg, Neeraj K.
   Jadon, Rajesh
   Sahu, Tejram
   Katare, Om Prakash
   Dalai, Sarat K.
   Awasthi, Amit
   Marepally, Srujan K.
TI Elastic liposome-mediated transdermal immunization enhanced the
   immunogenicity of P-falciparum surface antigen, MSP-1(19)
SO VACCINE
LA English
DT Article
DE Elastic liposome; Transdermal delivery; MSP-119; Langerhans cells;
   Cellular and humoral immunity; Vaccine; Immunization
ID ULTRADEFORMABLE DRUG CARRIERS; CARBOXYL-TERMINAL FRAGMENT; MOLECULAR
   WEIGHT SOLUTES; BLOOD-STAGE MALARIA; PROTECTIVE IMMUNITY;
   GAMMA-INTERFERON; TRANSCUTANEOUS IMMUNIZATION; DENDRITIC CELLS;
   ELECTRON-MICROSCOPY; DEFICIENT MICE
AB Transdermal immunization results in poor immunogenicity, which can be attributed to poor permeability of antigens through the skin. Therefore, elastic liposome, ultradeformable lipid vesicles, may overcome the challenges faced during transdermal immunization. This versatile carrier proves better vehicle for transcutaneous delivery of protein, peptide and nucleic acid antigens. The present results are suggestive of improved immunogenicity of carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 (PfMSP-1(19)) of Plasmodium falciparum when administered subcutaneously through elastic liposomes. The prepared elastic liposomes were characterized with respect to vesicles shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, stability and in vitro release. Humoral and cell-mediated immune (CMI) response elicited by topically applied PfMSP-1(19)-loaded elastic liposomes, intramuscularly administered alum-adsorbed PfMSP-1(19) solution, and topically applied PfMSP-1(19)-loaded conventional liposomes were compared and normalized with vehicle control. Results suggest greater transcutaneous immunization via elastic liposomes, and induced robust and perdurable IgG-specific antibody and cytophilic isotype responses. We report to have achieved sizeable CMI activating factor (IFN gamma), a crucial player in conferring resistance to asexual blood stage malaria, responses with elastic liposomes when compared with other formulations. The fluorescence microscopy and histopathology results are suggestive of prominent skin permeation and biodistribution, and demonstrate efficient delivery of malaria antigen via elastic liposomes to immunocompetent Langerhans cells (LC) and lymphatics. In conclusion, elastic liposomal formulation provided greater entrapment efficiency, enhanced penetration and heightened and long-lasting immune response. Moreover, effective immunoadjuvant property of this carrier justifies its potential for improved vaccine delivery, and opens new avenues to explore further on the development of malaria vaccine. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Tyagi, Rajeev K.] Georgia Regents Univ, Coll Dent Med, Dept Periodont, Augusta, GA 30912 USA.
   [Garg, Neeraj K.; Katare, Om Prakash] Panjab Univ, Univ Inst Pharmaceut Sci, Drug Delivery Res Grp, Chandigarh 160014, India.
   [Tyagi, Rajeev K.; Garg, Neeraj K.; Jadon, Rajesh] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Drug Delivery Res Lab, Sagar, MP, India.
   [Sahu, Tejram] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA.
   [Dalai, Sarat K.] Nirma Univ, Inst Sci, Ahmadabad 382481, Gujarat, India.
   [Awasthi, Amit] NCR Biotech Sci Cluster, Translat Hlth Sci & Technol Inst, Faridabad 121001, India.
   [Marepally, Srujan K.] Natl Ctr Biol Sci NCBS, Inst Stem Cell Biol & Regenerat Med InStem, Bangalore 560065, Karnataka, India.
RP Tyagi, RK (reprint author), Georgia Regents Univ, Coll Dent Med, Dept Periodont, Augusta, GA 30912 USA.
EM rajeev.dbt@gmail.com
OI Jadon, Rajesh/0000-0002-4109-2701
FU Department of Biotechnology (DBT), New Delhi, India; Council of
   Scientific and Industrial Research (CSIR HRDG) New Delhi, India
FX This work was funded by a grant from Department of Biotechnology (DBT),
   New Delhi, India and Council of Scientific and Industrial Research (CSIR
   HRDG) New Delhi, India. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. No additional external funding was received for this study.
NR 50
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U1 4
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD AUG 26
PY 2015
VL 33
IS 36
BP 4630
EP 4638
DI 10.1016/j.vaccine.2015.06.054
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CQ8OK
UT WOS:000360867500040
PM 26141014
ER

PT J
AU Su, WH
   Chiu, CC
   Shugart, YY
AF Su, Wen-Hui
   Chiu, Chi-Cking
   Shugart, Yin Yao
TI Heterogeneity revealed through meta-analysis might link geographical
   differences with nasopharyngeal carcinoma incidence in Han Chinese
   populations
SO BMC CANCER
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; SAMPLE-SIZE CALCULATIONS; SOUTHERN CHINESE;
   SUSCEPTIBILITY; TAIWAN; POWER; RISK; LOCI
AB Background: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy highly prevalent in southern China, and incidence rates among Han Chinese people vary according to geographic region. Recently, three independent genome-wide association studies (GWASs) confirmed that HLA-A is the main risk gene for NPC. However, the results of studies conducted in regions with dissimilar incidence rates contradicted the claims that HLA-A is the sole risk gene and that the association of rs29232 is independent of the HLA-A effect in the chromosome 6p21.3 region.
   Methods: We performed a meta-analysis, selecting five single-nucleotide polymorphisms (SNPs) in chromosome 6p21.3 mapped in three published GWASs and four case-control studies. The studies involved 8994 patients with NPC and 11,157 healthy controls, all of whom were Han Chinese.
   Results: The rs2517713 SNP located downstream of HLA-A was significantly associated with NPC (P = 1.08 x 10(-91), odds ratio [OR] = 0.58, 95 % confidence interval [CI] = 0.55-0.61). The rs29232 SNP exhibited a moderate level of heterogeneity (I-2 = 47 %) that disappeared (I-2 = 0 %) after stratification by moderate-and high-incidence NPC regions.
   Conclusions: Our results suggested that the HLA-A gene is strongly associated with NPC risk. In addition, the heterogeneity revealed by the meta-analysis of rs29232 might be associated with regional differences in NPC incidence among Han Chinese people. The higher OR of rs29232 and the fact that rs29232 was independent of the HLA-A effect in the moderate-incidence population suggested that rs29232 might have greater relevance to NPC incidence in a moderate-incidence population than in a high-incidence population.
C1 [Su, Wen-Hui] Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Dept Biomed Sci, Taoyuan, Taiwan.
   [Su, Wen-Hui; Chiu, Chi-Cking] Chang Gung Univ, Chang Gung Mol Med Res Ctr, Taoyuan, Taiwan.
   [Shugart, Yin Yao] NIMH, Div Intramural Res Programs, Unit Stat Genom, Bethesda, MD 20892 USA.
   [Shugart, Yin Yao] Johns Hopkins Med Sch, Dept Gastroenterol, Baltimore, MD USA.
RP Su, WH (reprint author), Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Dept Biomed Sci, Taoyuan, Taiwan.
EM whsu@mail.cgu.edu.tw; kay1yao@mail.nih.gov
FU Ministry of Education; National Science Council [NSC
   101-2314-B-182-051-MY3, MOST 104-2314-B-182-033-MY3]; Chang Gung
   Memorial Hospital, Taiwan [CMRPD1A0383, CMRPD3D0121]; Intramural
   Research Program at NIMH [MH002930-04]
FX The authors thank Wan-Lun Hsu for providing detailed data for the
   meta-analysis. This work was supported by the Ministry of Education
   (funding granted to Chang Gung University), the National Science Council
   (NSC 101-2314-B-182-051-MY3, MOST 104-2314-B-182-033-MY3), and Chang
   Gung Memorial Hospital (CMRPD1A0383, CMRPD3D0121), Taiwan. The funders
   played no role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. Dr. Shugart was
   supported by the Intramural Research Program at NIMH (MH002930-04).
NR 34
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD AUG 26
PY 2015
VL 15
AR 598
DI 10.1186/s12885-015-1607-0
PG 8
WC Oncology
SC Oncology
GA CP6FA
UT WOS:000359978900002
PM 26307051
ER

PT J
AU Lubega, M
   Nakyaanjo, N
   Nansubuga, S
   Hiire, E
   Kigozi, G
   Nakigozi, G
   Lutalo, T
   Nalugoda, F
   Serwadda, D
   Gray, R
   Wawer, M
   Kennedy, C
   Reynolds, SJ
AF Lubega, Muhamadi
   Nakyaanjo, Neema
   Nansubuga, Sumaya
   Hiire, Edgar
   Kigozi, Godfrey
   Nakigozi, Gertrude
   Lutalo, Tom
   Nalugoda, Fred
   Serwadda, David
   Gray, Ronald
   Wawer, Maria
   Kennedy, Caitylin
   Reynolds, Steven James
TI Risk Denial and Socio-Economic Factors Related to High HIV Transmission
   in a Fishing Community in Rakai, Uganda: A Qualitative Study
SO PLOS ONE
LA English
DT Article
ID LAKE VICTORIA; FOR-SEX; HIV/AIDS; PREVALENCE; PATTERNS; WOMEN
AB Background
   In Kasensero fishing community, home of the first recorded case of HIV in Uganda, HIV transmission is still very high with an incidence of 4.3 and 3.1 per 100 person-years in women and men, respectively, and an HIV prevalence of 44%, reaching up to 74% among female sex workers. We explored drivers for the high HIV transmission at Kasensero from the perspective of fishermen and other community members to inform future policy and preventive interventions.
   Methods
   20 in-depth interviews including both HIV positive and HIV negative respondents, and 12 focus-group discussions involving a total of 92 respondents from the Kasensero fishing community were conducted during April-September 2014. Content analysis was performed to identify recurrent themes.
   Results
   The socio-economic risk factors for high HIV transmission in Kasensero fishing community cited were multiple and cross-cutting and categorized into the following themes: power of money, risk denial, environmental triggers and a predisposing lifestyle and alcoholism and drug abuse. Others were: peer pressure, poor housing and the search for financial support for both the men and women which made them vulnerable to HIV exposure and or risk behavior.
   Conclusions
   There is a need for context specific combination prevention interventions in Kasensero that includes the fisher folk and other influential community leaders. Such groups could be empowered with the knowledge and social mobilization skills to fight the negative and risky behaviors, perceptions, beliefs, misconceptions and submission attitudes to fate that exposes the community to high HIV transmission. There is also need for government/partners to ensure effective policy implementation, life jackets for all fishermen, improve the poor housing at the community so as to reduce overcrowding and other housing related predispositions to high HIV rates at the community. Work place AIDS-competence teams have been successfully used to address high HIV transmission in similar settings.
C1 [Lubega, Muhamadi; Nakyaanjo, Neema; Hiire, Edgar; Kigozi, Godfrey; Nakigozi, Gertrude; Lutalo, Tom; Nalugoda, Fred; Serwadda, David; Gray, Ronald; Wawer, Maria; Reynolds, Steven James] Rakai Hlth Sci Program, Kalisizo, Uganda.
   [Lubega, Muhamadi] Karolinska Inst, Dept Publ Hlth Sci, Global Hlth IHCAR, S-17177 Stockholm, Sweden.
   [Lubega, Muhamadi] Busoga Univ, Sch Grad Studies & Res, Iganga, Uganda.
   [Lubega, Muhamadi; Reynolds, Steven James] NIAID, Div Intramural Res, NIH, Bethesda, MD 20892 USA.
   [Lubega, Muhamadi; Reynolds, Steven James] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Gray, Ronald; Wawer, Maria; Kennedy, Caitylin; Reynolds, Steven James] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Lubega, M (reprint author), Rakai Hlth Sci Program, Old Bukoba Rd,POB 279, Kalisizo, Uganda.
EM dlmuhamadi@yahoo.co.uk
FU National Institute of Allergy and Infectious Diseases [A1001040]
FX Funding provided by National Institute of Allergy and Infectious
   Diseases, Grant number A1001040. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 44
TC 2
Z9 2
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 26
PY 2015
VL 10
IS 8
AR e0132740
DI 10.1371/journal.pone.0132740
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP7LO
UT WOS:000360069400005
PM 26309179
ER

PT J
AU Pluchino, KM
   Esposito, D
   Moen, JK
   Hall, MD
   Madigan, JP
   Shukla, S
   Procter, LV
   Wall, VE
   Schneider, TD
   Pringle, I
   Ambudkar, SV
   Gill, DR
   Hyde, SC
   Gottesman, MM
AF Pluchino, Kristen M.
   Esposito, Dominic
   Moen, Janna K.
   Hall, Matthew D.
   Madigan, James P.
   Shukla, Suneet
   Procter, Lauren V.
   Wall, Vanessa E.
   Schneider, Thomas D.
   Pringle, Ian
   Ambudkar, Suresh V.
   Gill, Deborah R.
   Hyde, Steven C.
   Gottesman, Michael M.
TI Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a)
   P-Glycoprotein cDNA
SO PLOS ONE
LA English
DT Article
ID DRUG-RESISTANCE PROFILES; ESCHERICHIA-COLI; CYSTIC-FIBROSIS; FUNCTIONAL
   EXPRESSION; MULTIDRUG TRANSPORTER; MOLECULAR-BASIS; ATPASE ACTIVITY;
   BINDING-SITES; GENE; PHARMACOKINETICS
AB The efflux transporter P-glycoprotein (P-gp) is an important mediator of various pharmacokinetic parameters, being expressed at numerous physiological barriers and also in multi-drug-resistant cancer cells. Molecular cloning of homologous cDNAs is an important tool for the characterization of functional differences in P-gp between species. However, plasmids containing mouse mdr1a cDNA display significant genetic instability during cloning in bacteria, indicating that mdr1a cDNA may be somehow toxic to bacteria, allowing only clones containing mutations that abrogate this toxicity to survive transformation. We demonstrate here the presence of a cryptic promoter in mouse mdr1a cDNA that causes mouse P-gp expression in bacteria. This expression may account for the observed toxicity of mdr1a DNA to bacteria. Sigma 70 binding site analysis and GFP reporter plasmids were used to identify sequences in the first 321 bps of mdr1a cDNA capable of initiating bacterial protein expression. An mdr1a M107L cDNA containing a single residue mutation at the proposed translational start site was shown to allow sub-cloning of mdr1a in E. coli while retaining transport properties similar to wild-type P-gp. This mutant mdr1a cDNA may prove useful for efficient cloning of mdr1a in E. coli.
C1 [Pluchino, Kristen M.; Moen, Janna K.; Hall, Matthew D.; Madigan, James P.; Shukla, Suneet; Ambudkar, Suresh V.; Gottesman, Michael M.] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Esposito, Dominic; Procter, Lauren V.; Wall, Vanessa E.] Leidos Biomed Res Inc, Prot Express Lab, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Schneider, Thomas D.] NCI, Gene Regulat & Chromosome Biol Lab, Mol Informat Theory Grp, Frederick, MD 21701 USA.
   [Pringle, Ian; Gill, Deborah R.; Hyde, Steven C.] Univ Oxford, Radcliffe Dept Med, NDCLS, Gene Med Res Grp, Oxford, England.
RP Gottesman, MM (reprint author), NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA.
EM mgottesman@nih.gov
OI Hyde, Stephen/0000-0002-8877-4005; Schneider, Thomas/0000-0002-9841-1531
FU National Institutes of Health [HHSN261200800001E]; NIH, National Cancer
   Institute, Center for Cancer Research; National Cancer Institute
FX This project was funded in part with federal funds from the National
   Cancer Institute, National Institutes of Health, under contract number
   HHSN261200800001E and the by the Intramural Research Program of the NIH,
   National Cancer Institute, Center for Cancer Research.
NR 48
TC 3
Z9 3
U1 3
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 26
PY 2015
VL 10
IS 8
AR e0136396
DI 10.1371/journal.pone.0136396
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP7LO
UT WOS:000360069400120
PM 26309032
ER

PT J
AU Beryozkin, A
   Shevah, E
   Kimchi, A
   Mizrahi-Meissonnier, L
   Khateb, S
   Ratnapriya, R
   Lazar, CH
   Blumenfeld, A
   Ben-Yosef, T
   Hemo, Y
   Pe'er, J
   Averbuch, E
   Sagi, M
   Boleda, A
   Gieser, L
   Zlotogorski, A
   Falik-Zaccai, T
   Alimi-Kasem, O
   Jacobson, SG
   Chowers, I
   Swaroop, A
   Banin, E
   Sharon, D
AF Beryozkin, Avigail
   Shevah, Elia
   Kimchi, Adva
   Mizrahi-Meissonnier, Liliana
   Khateb, Samer
   Ratnapriya, Rinki
   Lazar, Csilla H.
   Blumenfeld, Anat
   Ben-Yosef, Tamar
   Hemo, Yitzhak
   Pe'er, Jacob
   Averbuch, Eduard
   Sagi, Michal
   Boleda, Alexis
   Gieser, Linn
   Zlotogorski, Abraham
   Falik-Zaccai, Tzipora
   Alimi-Kasem, Ola
   Jacobson, Samuel G.
   Chowers, Itay
   Swaroop, Anand
   Banin, Eyal
   Sharon, Dror
TI Whole Exome Sequencing Reveals Mutations in Known Retinal Disease Genes
   in 33 out of 68 Israeli Families with Inherited Retinopathies
SO SCIENTIFIC REPORTS
LA English
DT Article
ID JUVENILE MACULAR DYSTROPHY; NONSYNDROMIC RETINITIS-PIGMENTOSA; LEBER
   CONGENITAL AMAUROSIS; BARDET-BIEDL SYNDROME; ENCODING P-CADHERIN;
   MISSENSE MUTATION; CDH3 MUTATIONS; HYPOTRICHOSIS; PREVALENCE; SPECTRUM
AB Whole exome sequencing (WES) is a powerful technique for identifying sequence changes in the human genome. The goal of this study was to delineate the genetic defects in patients with inherited retinal diseases (IRDs) using WES. WES was performed on 90 patient DNA samples from 68 families and 226 known genes for IRDs were analyzed. Sanger sequencing was used to validate potential pathogenic variants that were also subjected to segregation analysis in families. Thirty-three causative mutations (19 novel and 14 known) in 25 genes were identified in 33 of the 68 families. The vast majority of mutations (30 out of 33) have not been reported in the Israeli and the Palestinian populations. Nine out of the 33 mutations were detected in additional families from the same ethnic population, suggesting a founder effect. In two families, identified phenotypes were different from the previously reported clinical findings associated with the causative gene. This is the largest genetic analysis of IRDs in the Israeli and Palestinian populations to date. We also demonstrate that WES is a powerful tool for rapid analysis of known disease genes in large patient cohorts.
C1 [Beryozkin, Avigail; Shevah, Elia; Kimchi, Adva; Mizrahi-Meissonnier, Liliana; Khateb, Samer; Blumenfeld, Anat; Hemo, Yitzhak; Pe'er, Jacob; Averbuch, Eduard; Chowers, Itay; Banin, Eyal; Sharon, Dror] Hadassah Hebrew Univ, Med Ctr, Dept Ophthalmol, Jerusalem, Israel.
   [Ratnapriya, Rinki; Lazar, Csilla H.; Boleda, Alexis; Gieser, Linn; Swaroop, Anand] NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA.
   [Lazar, Csilla H.] Univ Babes Bolyai, Mol Biol Ctr, Interdisciplinary Res Inst Bionano Sci, Cluj Napoca 400271, Romania.
   [Ben-Yosef, Tamar] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Sagi, Michal] Hadassah Hebrew Univ, Med Ctr, Human Genet, Jerusalem, Israel.
   [Zlotogorski, Abraham] Hadassah Hebrew Univ, Med Ctr, Dermatol, Jerusalem, Israel.
   [Falik-Zaccai, Tzipora] Inst Human Genet, Galilee Med Ctr, Nahariyya, Israel.
   [Falik-Zaccai, Tzipora] Galilee Fac Med, Bar Ilan, Israel.
   [Alimi-Kasem, Ola] Haemek Hosp, Afula, Israel.
   [Jacobson, Samuel G.] Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA.
RP Swaroop, A (reprint author), NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA.
EM swaroopa@nei.nih.gov; banine@cc.huji.ac.il; dror.sharon1@gmail.com
RI Sharon, Dror/P-4539-2015; 
OI Sharon, Dror/0000-0002-1789-5811; Swaroop, Anand/0000-0002-1975-1141
FU Foundation Fighting Blindness USA [BR-GE-0510-0490-HUJ,
   BR-GE-0214-0639]; Binational US-Israel foundation (BSF) [2011202];
   Yedidut 1 research grant; National Eye Institute, National Institutes of
   Health, USA
FX Some of the data were collected by two clinical researchers who passed
   away during the study: Prof. David Ben-Ezra and Prof. Saul Merin. This
   study was supported by the Foundation Fighting Blindness USA
   (BR-GE-0510-0490-HUJ and BR-GE-0214-0639 to DS), Binational US-Israel
   foundation (BSF-grant number 2011202 to DS and AS), the Yedidut 1
   research grant (to EB) and the intramural research program of the
   National Eye Institute, National Institutes of Health, USA (to AS).
NR 39
TC 12
Z9 12
U1 1
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 26
PY 2015
VL 5
AR 13187
DI 10.1038/srep13187
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP7EE
UT WOS:000360049200001
PM 26306921
ER

PT J
AU Manor, U
   Bartholomew, S
   Golani, G
   Christenson, E
   Kozlov, M
   Higgs, H
   Spudich, J
   Lippincott-Schwartz, J
AF Manor, Uri
   Bartholomew, Sadie
   Golani, Gonen
   Christenson, Eric
   Kozlov, Michael
   Higgs, Henry
   Spudich, James
   Lippincott-Schwartz, Jennifer
TI A mitochondria-anchored isoform of the actin-nucleating spire protein
   regulates mitochondrial division
SO ELIFE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM; AXONAL-TRANSPORT; CELL-DIVISION; IN-VIVO;
   FISSION; FORMIN; COMPLEX; MEMBRANES; POLYMERIZATION; MECHANISM
AB Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria. The force for constriction is thought to involve actin polymerization by the ER-anchored isoform of the formin protein inverted formin 2 (INF2). Unknown is the mechanism triggering INF2-mediated actin polymerization at ER-mitochondria intersections. We show that a novel isoform of the formin-binding, actin-nucleating protein Spire, Spire1C, localizes to mitochondria and directly links mitochondria to the actin cytoskeleton and the ER. Spire1C binds INF2 and promotes actin assembly on mitochondrial surfaces. Disrupting either Spire1C actin-or formin-binding activities reduces mitochondrial constriction and division. We propose Spire1C cooperates with INF2 to regulate actin assembly at ER-mitochondrial contacts. Simulations support this model's feasibility and demonstrate polymerizing actin filaments can induce mitochondrial constriction. Thus, Spire1C is optimally positioned to serve as a molecular hub that links mitochondria to actin and the ER for regulation of mitochondrial division.
C1 [Manor, Uri; Lippincott-Schwartz, Jennifer] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, Bethesda, MD USA.
   [Bartholomew, Sadie; Spudich, James] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA.
   [Golani, Gonen; Kozlov, Michael] Tel Aviv Univ, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel.
   [Christenson, Eric] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Struct & Chem Biol Membrane Prot, Bethesda, MD USA.
   [Higgs, Henry] Geisel Sch Med, Dept Biochem, Hanover, NH USA.
RP Lippincott-Schwartz, J (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, Bethesda, MD USA.
EM lippincj@mail.nih.gov
OI Manor, Uri/0000-0002-9802-1955
FU Israel Science Foundation (ISF) [758/11]; National Institutes of Health
   (NIH) [5R01GM106000-03, 5R01GM033289-32, 1ZIAHD001609-21,
   1ZIAHD008928-02]
FX Israel Science Foundation (ISF) 758/11 Gonen Golani, Michael Kozlov;
   National Institutes of Health (NIH) 5R01GM106000-03 Henry Higgs;
   National Institutes of Health (NIH) 5R01GM033289-32 James Spudich;
   National Institutes of Health (NIH) 1ZIAHD001609-21 Uri Manor, Jennifer
   Lippincott-Schwartz; National Institutes of Health (NIH) 1ZIAHD008928-02
   Eric Christenson
NR 68
TC 20
Z9 20
U1 3
U2 4
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 25
PY 2015
VL 4
AR e08828
DI 10.7554/eLife.08828
PG 27
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA DI9JA
UT WOS:000373817500001
ER

PT J
AU Wrobel, K
   Stevens, SR
   Jones, RH
   Selzman, CH
   Lamy, A
   Beaver, TM
   Djokovic, LT
   Wang, N
   Velazquez, EJ
   Sopko, G
   Kron, IL
   DiMaio, JM
   Michler, RE
   Lee, KL
   Yii, M
   Leng, CY
   Zembala, M
   Rouleau, JL
   Daly, RC
   Al-Khalidi, HR
AF Wrobel, Krzysztof
   Stevens, Susanna R.
   Jones, Robert H.
   Selzman, Craig H.
   Lamy, Andre
   Beaver, Thomas M.
   Djokovic, Ljubomir T.
   Wang, Nan
   Velazquez, Eric J.
   Sopko, George
   Kron, Irving L.
   DiMaio, J. Michael
   Michler, Robert E.
   Lee, Kerry L.
   Yii, Michael
   Leng, Chua Yeow
   Zembala, Marian
   Rouleau, Jean L.
   Daly, Richard C.
   Al-Khalidi, Hussein R.
TI y Influence of Baseline Characteristics, Operative Conduct, and
   Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass
   Grafting Among Patients With Left Ventricular Dysfunction Results From
   the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
SO CIRCULATION
LA English
DT Article
DE coronary artery disease; heart failure; myocardial revascularization;
   surgery
ID RISK-EVALUATION EUROSCORE; MITRAL REGURGITATION; EUROPEAN SYSTEM;
   SURGERY; MORTALITY; SURVIVAL; REVASCULARIZATION; PREDICTORS; DISEASE
AB Background Patients with severe left ventricular dysfunction, ischemic heart failure, and coronary artery disease suitable for coronary artery bypass grafting (CABG) are at higher risk for surgical morbidity and mortality. Paradoxically, those patients with the most severe coronary artery disease and ventricular dysfunction who derive the greatest clinical benefit from CABG are also at the greatest operative risk, which makes decision making regarding whether to proceed to surgery difficult in such patients. To better inform such decision making, we analyzed the Surgical Treatment for Ischemic Heart Failure (STICH) CABG population for detailed information on perioperative risk and outcomes.
   Methods and Results In both STICH trials (hypotheses), 2136 patients with a left ventricular ejection fraction of 35% and coronary artery disease were allocated to medical therapy, CABG plus medical therapy, or CABG with surgical ventricular reconstruction. Relationships of baseline characteristics and operative conduct with morbidity and mortality at 30 days were evaluated. There were a total of 1460 patients randomized to and receiving surgery, and 346 (approximate to 25%) of these high-risk patients developed a severe complication within 30 days. Worsening renal insufficiency, cardiac arrest with cardiopulmonary resuscitation, and ventricular arrhythmias were the most frequent complications and those most commonly associated with death. Mortality at 30 days was 5.1% and was generally preceded by a serious complication (65 of 74 deaths). Left ventricular size, renal dysfunction, advanced age, and atrial fibrillation/flutter were significant preoperative predictors of mortality within 30 days. Cardiopulmonary bypass time was the only independent surgical variable predictive of 30-day mortality.
   Conclusions CABG can be performed with relatively low 30-day mortality in patients with left ventricular dysfunction. Serious postoperative complications occurred in nearly 1 in 4 patients and were associated with mortality.
   Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00023595.
C1 [Wrobel, Krzysztof] Allenort Hosp, Warsaw, Poland.
   [Wrobel, Krzysztof] John Paul 2 Hosp, Krakow, Poland.
   [Stevens, Susanna R.; Jones, Robert H.; Velazquez, Eric J.; Lee, Kerry L.; Al-Khalidi, Hussein R.] Duke Clin Res Inst, Durham, NC 27705 USA.
   [Jones, Robert H.; Velazquez, Eric J.; Lee, Kerry L.; Al-Khalidi, Hussein R.] Duke Univ, Sch Med, Durham, NC USA.
   [Selzman, Craig H.] Univ Utah, Salt Lake City, UT USA.
   [Lamy, Andre] McMaster Univ, Hamilton Gen Hosp, Hamilton, ON, Canada.
   [Beaver, Thomas M.] Univ Florida, Shands Hosp, Gainesville, FL USA.
   [Djokovic, Ljubomir T.] Dedinje Cardiovasc Inst, Belgrade, Serbia.
   [Wang, Nan] Loma Linda Univ, Med Ctr, Loma Linda, CA 92350 USA.
   [Sopko, George] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Kron, Irving L.] Univ Virginia, Charlottesville, VA USA.
   [DiMaio, J. Michael] Baylor Univ, Med Ctr, Dallas, TX USA.
   [Michler, Robert E.] Montefiore Med Ctr, New York, NY USA.
   [Michler, Robert E.] Albert Einstein Coll Med, New York, NY USA.
   [Yii, Michael] St Vincents Hosp Melbourne, Melbourne, Vic, Australia.
   [Yii, Michael] Univ Melbourne, Melbourne, Vic 3010, Australia.
   [Leng, Chua Yeow] Natl Heart Ctr Singapore, Singapore, Singapore.
   [Zembala, Marian] Silesian Ctr Heart Dis Zabrze, Silesian, Poland.
   [Rouleau, Jean L.] Univ Montreal, Montreal Heart Inst, Montreal, PQ H3C 3J7, Canada.
   [Daly, Richard C.] Mayo Clin, Rochester, MN USA.
RP Al-Khalidi, HR (reprint author), Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
EM hussein.al-khalidi@duke.edu
FU National Institutes of Health/National Heart, Lung, and Blood Institute
   [U01HL69015, U01HL69013]
FX This work was supported by grants U01HL69015 and U01HL69013 from the
   National Institutes of Health/National Heart, Lung, and Blood Institute.
   This work is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health or National Heart, Lung, and Blood Institute.
NR 29
TC 5
Z9 7
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD AUG 25
PY 2015
VL 132
IS 8
BP 720
EP 730
DI 10.1161/CIRCULATIONAHA.114.014932
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA CP9HN
UT WOS:000360204800009
PM 26304663
ER

PT J
AU Ziats, MN
   Edmonson, C
   Rennert, OM
AF Ziats, Mark N.
   Edmonson, Catherine
   Rennert, Owen M.
TI The autistic brain in the context of normal neurodevelopment
SO FRONTIERS IN NEUROANATOMY
LA English
DT Article
DE autistic disorder; autism spectrum disorder; neurodevelopment;
   microglia; mini-columns; neural networks
ID CEREBRAL CORTICAL DEVELOPMENT; NEURONAL DEVELOPMENT; DEVELOPING
   NEOCORTEX; SPECTRUM DISORDERS; CORTEX; MICROGLIA; CELLS; HINDBRAIN;
   IDENTITY; DISEASE
AB The etiology of autism spectrum disorders (ASDs) is complex and largely unclear. Among various lines of inquiry, many have suggested convergence onto disruptions in both neural circuitry and immune regulation/glial cell function pathways. However, the interpretation of the relationship between these two putative mechanisms has largely focused on the role of exogenous factors and insults, such as maternal infection, in activating immune pathways that in turn result in neural network abnormalities. Yet, given recent insights into our understanding of human neurodevelopment, and in particular the critical role of glia and the immune system in normal brain development, it is important to consider these putative pathological processes in their appropriate normal neurodevelopmental context. In this review, we explore the hypothesis that the autistic brain cellular phenotype likely represents intrinsic abnormalities of glial/immune processes constitutively operant in normal brain development that result in the observed neural network dysfunction. We review recent studies demonstrating the intercalated role of neural circuit development, the immune system, and glial cells in the normal developing brain, and integrate them with studies demonstrating pathological alterations in these processes in autism. By discussing known abnormalities in the autistic brain in the context of normal brain development, we explore the hypothesis that the glial/immune component of ASD may instead be related to intrinsic exaggerated/abnormal constitutive neurodevelopmental processes such as network pruning. Moreover, this hypothesis may be relevant to other neurodevelopmental disorders that share genetic, pathologic, and clinical features with autism.
C1 [Ziats, Mark N.; Edmonson, Catherine; Rennert, Owen M.] NICHHD, NIH, Bethesda, MD 20814 USA.
   [Ziats, Mark N.] Baylor Coll Med, Med Sci Training Program, Houston, TX 77030 USA.
   [Edmonson, Catherine] Univ Florida, Coll Med, Gainesville, FL USA.
RP Ziats, MN (reprint author), NICHHD, NIH, 49 Convent Dr,Bldg 49,Room 2c08, Bethesda, MD 20814 USA.
EM ziats@bcm.edu
FU National Institute of Child Health and Human Development, NIH;
   NIH-Cambridge Biomedical Scholars Program; Baylor College of Medicine
   Medical Scientist Training Program
FX This work was supported by the Intramural Research Program (IRP) of the
   National Institute of Child Health and Human Development, NIH. MNZ was
   also supported by the NIH-Cambridge Biomedical Scholars Program, and the
   Baylor College of Medicine Medical Scientist Training Program.
NR 73
TC 2
Z9 2
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1662-5129
J9 FRONT NEUROANAT
JI Front. Neuroanat.
PD AUG 25
PY 2015
VL 9
AR 115
DI 10.3389/forna.2015.00115
PG 7
WC Anatomy & Morphology; Neurosciences
SC Anatomy & Morphology; Neurosciences & Neurology
GA CQ2MD
UT WOS:000360433600001
PM 26379512
ER

PT J
AU Chew, EY
   Clemons, TE
   Agron, E
   Launer, LJ
   Grodstein, F
   Bernstein, PS
AF Chew, Emily Y.
   Clemons, Traci E.
   Agron, Elvira
   Launer, Lenore J.
   Grodstein, Francine
   Bernstein, Paul S.
CA Age-Related Eye Disease Study 2
TI Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient
   Supplementation on Cognitive Function The AREDS2 Randomized Clinical
   Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID LUTEIN PLUS ZEAXANTHIN; DOCOSAHEXAENOIC ACID; ALZHEIMERS-DISEASE;
   BETA-CAROTENE; EYE DISEASE; MACULAR DEGENERATION; AGE; WOMEN;
   ANTIOXIDANTS; CANCER
AB IMPORTANCE Observational data have suggested that high dietary intake of saturated fat and low intake of vegetables may be associated with increased risk of Alzheimer disease.
   OBJECTIVE To test the effects of oral supplementation with nutrients on cognitive function.
   DESIGN, SETTING, AND PARTICIPANTS In a double-masked randomized clinical trial (the Age-Related Eye Disease Study 2 [AREDS2]), retinal specialists in 82 US academic and community medical centers enrolled and observed participants who were at risk for developing late age-related macular degeneration (AMD) from October 2006 to December 2012. In addition to annual eye examinations, several validated cognitive function tests were administered via telephone by trained personnel at baseline and every 2 years during the 5-year study.
   INTERVENTIONS Long-chain polyunsaturated fatty acids (LCPUFAs) (1 g) and/or lutein (10mg)/zeaxanthin (2mg) vs placebo were tested in a factorial design. All participants were also given varying combinations of vitamins C, E, beta carotene, and zinc.
   MAIN OUTCOMES AND MEASURES The main outcome was the yearly change in composite scores determined from a battery of cognitive function tests from baseline. The analyses, which were adjusted for baseline age, sex, race, history of hypertension, education, cognitive score, and depression score, evaluated the differences in the composite score between the treated vs untreated groups. The composite score provided an overall score for the battery, ranging from -22 to 17, with higher scores representing better function.
   RESULTS A total of 89%(3741/4203) of AREDS2 participants consented to the ancillary cognitive function study and 93.6%(3501/3741) underwent cognitive function testing. The mean (SD) age of the participants was 72.7 (7.7) years and 57.5% were women. There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. The yearly change in the composite cognitive function score was -0.19 (99% CI, -0.25 to -0.13) for participants randomized to receive LCPUFAs vs -0.18 (99% CI, -0.24 to -0.12) for those randomized to no LCPUFAs (difference in yearly change, -0.03 [99% CI, -0.20 to 0.13]; P = .63). Similarly, the yearly change in the composite cognitive function score was -0.18 (99% CI, -0.24 to -0.11) for participants randomized to receive lutein/zeaxanthin vs -0.19 (99% CI, -0.25 to -0.13) for those randomized to not receive lutein/zeaxanthin (difference in yearly change, 0.03 [99% CI, -0.14 to 0.19]; P = .66). Analyses were also conducted to assess for potential interactions between LCPUFAs and lutein/zeaxanthin and none were found to be significant.
   CONCLUSIONS AND RELEVANCE Among older persons with AMD, oral supplementation with LCPUFAs or lutein/zeaxanthin had no statistically significant effect on cognitive function.
C1 [Chew, Emily Y.; Agron, Elvira] NEI, Div Epidemiol & Clin Applicat, Clin Trials Branch, NIH, Bethesda, MD 20892 USA.
   [Clemons, Traci E.] EMMES Corp, Rockville, MD USA.
   [Launer, Lenore J.] NIA, Neuroepidemiol Sect, NIH, Bethesda, MD 20892 USA.
   [Grodstein, Francine] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA.
   [Grodstein, Francine] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Bernstein, Paul S.] Univ Utah, Moran Eye Ctr, Salt Lake City, UT USA.
RP Chew, EY (reprint author), BG 10-CRC Room 3-2531,10 Ctr Dr MSC1204, Bethesda, MD 20892 USA.
EM echew@nei.nih.gov
FU NIH; National Eye Institute (NEI)/NIH, Department of Health and Human
   Services [HHS-N-260-2005-00007-C]; NIH, Office of Dietary Supplements
   (ODS); NIH, National Center for Complementary and Alternative Medicine
   (NCCAM); NIH, National Institute on Aging (NIA); NIH, National Heart,
   Lung, and Blood Institute (NHLBI); NIH, National Institute of
   Neurological Disorders and Stroke (NINDS);  [N01-EY-5-0007]
FX This study was sponsored by the NIH; by the intramural program funds and
   contracts from the National Eye Institute (NEI)/NIH, Department of
   Health and Human Services, contract HHS-N-260-2005-00007-C. ADB and
   contract N01-EY-5-0007. Funds were generously contributed to these
   contracts by the following NIH institutes: Office of Dietary Supplements
   (ODS), National Center for Complementary and Alternative Medicine
   (NCCAM), National Institute on Aging (NIA), National Heart, Lung, and
   Blood Institute (NHLBI), and National Institute of Neurological
   Disorders and Stroke (NINDS).
NR 29
TC 22
Z9 22
U1 8
U2 35
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 25
PY 2015
VL 314
IS 8
BP 791
EP 801
DI 10.1001/jama.2015.9677
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA CP6SA
UT WOS:000360017200019
PM 26305649
ER

PT J
AU Knapper, JT
   Ghasemzadeh, N
   Khayata, M
   Patel, SP
   Quyyumi, AA
   Mendis, S
   Mensah, GA
   Taubert, K
   Sperling, LS
AF Knapper, Joseph T.
   Ghasemzadeh, Nima
   Khayata, Mohamed
   Patel, Sulay P.
   Quyyumi, Arshed A.
   Mendis, Shanthi
   Mensah, George A.
   Taubert, Kathryn
   Sperling, Laurence S.
TI Time to Change Our Focus Defining, Promoting, and Impacting
   Cardiovascular Population Health
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE exercise; prevention; lifestyle; nutrition
ID AMERICAN-HEART-ASSOCIATION; PHYSICAL-ACTIVITY INTERVENTION; STYLE
   BEHAVIOR-CHANGE; NEW-YORK-CITY; PUBLIC-HEALTH; SCIENTIFIC STATEMENT;
   COST-EFFECTIVENESS; LIFE-STYLE; SEDENTARY BEHAVIORS; ALCOHOL-CONSUMPTION
AB Despite numerous groundbreaking advances in the field, cardiovascular disease remains the leading cause of mortality in the United States, accounting for more than 787,000 deaths per year. Already leading the world in per capita healthcare expenditure, U.S. medical costs related to cardiovascular disease are projected to triple by 2030, to over $800 billion annually. The medical community's traditional disproportionate focus on treating cardiovascular disease, relative to promoting cardiovascular health, is an important contributor to these expenses. To ensure continued reductions in the burden of cardiovascular disease, as well as the overall sustainability of the healthcare system, a paradigm shift that places more emphasis on cardiovascular health promotion throughout the life course is required. This review will discuss the current definitions of cardiovascular health, as well as strategies for promoting and impacting cardiovascular health at both the local and national level. (C) 2015 by the American College of Cardiology Foundation.
C1 [Knapper, Joseph T.; Ghasemzadeh, Nima; Khayata, Mohamed; Patel, Sulay P.; Quyyumi, Arshed A.; Sperling, Laurence S.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
   [Mendis, Shanthi] WHO, Chron Dis Prevent & Management, Dept Chron Dis & Hlth Promot, CH-1211 Geneva, Switzerland.
   [Mensah, George A.] NHLBI, Ctr Translat Res & Implementat Sci, Bethesda, MD 20892 USA.
   [Taubert, Kathryn] World Heart Federat, Geneva, Switzerland.
RP Sperling, LS (reprint author), Emory Univ, Sch Med, 1365 Clifton Rd NE,Bldg A,Suite 2200, Atlanta, GA 30322 USA.
EM lsperli@emory.edu
OI KHAYATA, MOHAMED/0000-0001-8116-4311
FU World Health Organization [001]
NR 86
TC 4
Z9 4
U1 4
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD AUG 25
PY 2015
VL 66
IS 8
BP 960
EP 971
DI 10.1016/j.jacc.2015.07.008
PG 12
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA CP5VQ
UT WOS:000359953500012
PM 26293767
ER

PT J
AU Stahl, S
   Seidl, ARDM
   Ducret, A
   van Geijtenbeek, SK
   Michel, S
   Racek, T
   Birzele, F
   Haas, AK
   Rueger, R
   Gerg, M
   Niederfellner, G
   Pastan, I
   Brinkmann, U
AF Stahl, Sebastian
   Seidl, Ana Rita da Silva Mateus
   Ducret, Axel
   van Geijtenbeek, Sabine Kux
   Michel, Sven
   Racek, Tomas
   Birzele, Fabian
   Haas, Alexander K.
   Rueger, Ruediger
   Gerg, Michael
   Niederfellner, Gerhard
   Pastan, Ira
   Brinkmann, Ulrich
TI Loss of diphthamide pre-activates NF-kappa B and death receptor pathways
   and renders MCF7 cells hypersensitive to tumor necrosis factor
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE ADP-ribosylation of eEF2; Pseudomonas exotoxin; diphtheria toxin;
   translation; DPH gene knockout
ID ELONGATION-FACTOR 2; PHASE-I TRIAL; SEGREGATION GENE CSE1; IMMUNOTOXIN
   RFB4(DSFV)-PE38 BL22; DIPHTHERIA-TOXIN; ADP-RIBOSYLATION; TRANSLATION
   ELONGATION; MEDIATED APOPTOSIS; PROTEIN-SYNTHESIS; HUMAN HOMOLOG
AB The diphthamide on human eukaryotic translation elongation factor 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE). This modification is synthesized by seven dipthamide biosynthesis proteins (DPH1-DPH7) and is conserved among eukaryotes and archaea. We generated MCF7 breast cancer cell line-derived DPH gene knockout (ko) cells to assess the impact of complete or partial inactivation on diphthamide synthesis and toxin sensitivity, and to address the biological consequence of diphthamide deficiency. Cells with heterozygous gene inactivation still contained predominantly diphthamide-modified eEF2 and were as sensitive to PE and DT as parent cells. Thus, DPH gene copy number reduction does not affect overall diphthamide synthesis and toxin sensitivity. Complete inactivation of DPH1, DPH2, DPH4, and DPH5 generated viable cells without diphthamide. DPH1ko, DPH2ko, and DPH4ko harbored unmodified eEF2 and DPH5ko ACP-(diphthine-precursor) modified eEF2. Loss of diphthamide prevented ADP ribosylation of eEF2, rendered cells resistant to PE and DT, but does not affect sensitivity toward other protein synthesis inhibitors, such as saporin or cycloheximide. Surprisingly, cells without diphthamide (independent of which the DPH gene compromised) were presensitized toward nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappa B) and death-receptor pathways without crossing lethal thresholds. In consequence, loss of diphthamide rendered cells hypersensitive toward TNF-mediated apoptosis. This finding suggests a role of diphthamide in modulating NF-kappa B, death receptor, or apoptosis pathways.
C1 [Stahl, Sebastian; Haas, Alexander K.; Brinkmann, Ulrich] Roche Innovat Ctr Penzberg, Roche Pharma Res & Early Dev, Large Mol Res, D-82377 Penzberg, Germany.
   [Seidl, Ana Rita da Silva Mateus; Niederfellner, Gerhard] Roche Innovat Ctr Penzberg, Roche Pharma Res & Early Dev, Discovery Oncol, D-82377 Penzberg, Germany.
   [Ducret, Axel; van Geijtenbeek, Sabine Kux; Michel, Sven] Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Pharmaceut Sci Translat Technol & Bioinformat, CH-4070 Basel, Switzerland.
   [Racek, Tomas; Birzele, Fabian; Rueger, Ruediger] Roche Innovat Ctr Penzberg, Roche Pharma Res & Early Dev, Pharmaceut Sci Translat Technol & Bioinformat, D-82377 Penzberg, Germany.
   [Gerg, Michael] Roche Profess Diagnost, Roche Diagnost, Biol Rare Reagents, D-82377 Penzberg, Germany.
   [Pastan, Ira] NCI, Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Pastan, I (reprint author), NCI, Mol Biol Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA.
EM pastani@mail.nih.gov; ulrich.brinkmann@roche.com
FU National Institutes of Health, National Cancer Institute, Center for
   Cancer Research; Roche Pharma Research and Early Development (pRED)
FX We thank Klaus Mayer, Hedda Herrmuth, Claudia Kirstenpfad, Andrea
   Herold, and Beatrix Bahle for excellent operative support. This research
   was supported in part by the Intramural Research Program of the National
   Institutes of Health, National Cancer Institute, Center for Cancer
   Research, and in part by Roche Pharma Research and Early Development
   (pRED). S. S. is a fellow of the Roche Postdoc Fund.
NR 48
TC 2
Z9 2
U1 0
U2 3
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 25
PY 2015
VL 112
IS 34
BP 10732
EP 10737
DI 10.1073/pnas.1512863112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP6NZ
UT WOS:000360005600059
PM 26261303
ER

PT J
AU Cortese-Krott, MM
   Kuhnle, GGC
   Dyson, A
   Fernandez, BO
   Grman, M
   DuMond, JF
   Barrow, MP
   McLeod, G
   Nakagawa, H
   Ondrias, K
   Nagy, P
   King, SB
   Saavedra, JE
   Keefer, LK
   Singer, M
   Kelm, M
   Butler, AR
   Feelisch, M
AF Cortese-Krott, Miriam M.
   Kuhnle, Gunter G. C.
   Dyson, Alex
   Fernandez, Bernadette O.
   Grman, Marian
   DuMond, Jenna F.
   Barrow, Mark P.
   McLeod, George
   Nakagawa, Hidehiko
   Ondrias, Karol
   Nagy, Peter
   King, S. Bruce
   Saavedra, Joseph E.
   Keefer, Larry K.
   Singer, Mervyn
   Kelm, Malte
   Butler, Anthony R.
   Feelisch, Martin
TI Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid
   species, polysulfides, and nitroxyl
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE sulfide; nitric oxide; nitroxyl; redox; gasotransmitter
ID NITROSOHYDROXYLAMINE-N-SULFONATE; NITRIC-OXIDE DONORS; HYDROGEN-SULFIDE;
   S-NITROSOTHIOLS; NITROGEN MONOXIDE; ZUR KENNTNIS; IN-VIVO; CHEMISTRY;
   SULFUR; H2S
AB Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H2S) signaling pathways are intimately intertwined, with mutual attenuation or potentiation of biological responses in the cardiovascular system and elsewhere. The chemical basis of this interaction is elusive. Moreover, polysulfides recently emerged as potential mediators of H2S/sulfide signaling, but their biosynthesis and relationship to NO remain enigmatic. We sought to characterize the nature, chemical biology, and bioactivity of key reaction products formed in the NO/sulfide system. At physiological pH, we find that NO and sulfide form a network of cascading chemical reactions that generate radical intermediates as well as anionic and uncharged solutes, with accumulation of three major products: nitrosopersulfide (SSNO-), polysulfides, and dinitrososulfite [N-nitrosohydroxylamine-N-sulfonate (SULFI/NO)], each with a distinct chemical biology and in vitro and in vivo bioactivity. SSNO- is resistant to thiols and cyanolysis, efficiently donates both sulfane sulfur and NO, and potently lowers blood pressure. Polysulfides are both intermediates and products of SSNO- synthesis/decomposition, and they also decrease blood pressure and enhance arterial compliance. SULFI/NO is a weak combined NO/nitroxyl donor that releases mainly N2O on decomposition; although it affects blood pressure only mildly, it markedly increases cardiac contractility, and formation of its precursor sulfite likely contributes to NO scavenging. Our results unveil an unexpectedly rich network of coupled chemical reactions between NO and H2S/sulfide, suggesting that the bioactivity of either transmitter is governed by concomitant formation of polysulfides and anionic S/N-hybrid species. This conceptual framework would seem to offer ample opportunities for the modulation of fundamental biological processes governed by redox switching and sulfur trafficking.
C1 [Cortese-Krott, Miriam M.; Kelm, Malte] Univ Dusseldorf, Fac Med, Dept Cardiol Pneumol & Angiol, Cardiovasc Res Lab, D-40225 Dusseldorf, Germany.
   [Kuhnle, Gunter G. C.] Univ Reading, Dept Nutr, Reading RG6 6AP, Berks, England.
   [Dyson, Alex; Singer, Mervyn] UCL, Bloomsbury Inst Intens Care Med, London WC1E 6BT, England.
   [Fernandez, Bernadette O.; Feelisch, Martin] Univ Southampton, Southampton Gen Hosp, Fac Med, Clin & Expt Sci, Southampton SO16 6YD, Hants, England.
   [Fernandez, Bernadette O.; Feelisch, Martin] Inst Life Sci, Southampton SO16 6YD, Hants, England.
   [Grman, Marian; Ondrias, Karol] Slovak Acad Sci, Ctr Mol Med, Bratislava 83101, Slovakia.
   [DuMond, Jenna F.; King, S. Bruce] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA.
   [Barrow, Mark P.] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England.
   [McLeod, George] Bruker UK Ltd, Coventry CV4 9GH, W Midlands, England.
   [Nakagawa, Hidehiko] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Organ & Med Chem, Nagoya, Aichi 4678603, Japan.
   [Nagy, Peter] Natl Inst Oncol, Dept Mol Immunol & Toxicol, H-1122 Budapest, Hungary.
   [Saavedra, Joseph E.] NCI, Leidos Biomed Res Inc, Frederick, MD 21702 USA.
   [Keefer, Larry K.] NCI, Frederick, MD 21702 USA.
   [Butler, Anthony R.] Univ St Andrews, Sch Med, St Andrews KY16 9AJ, Fife, Scotland.
RP Feelisch, M (reprint author), Univ Southampton, Southampton Gen Hosp, Fac Med, Clin & Expt Sci, Southampton SO16 6YD, Hants, England.
EM M.Feelisch@soton.ac.uk
RI Nagy, Peter/C-6768-2008; Barrow, Mark/C-3145-2009; 
OI Nagy, Peter/0000-0003-3393-235X; Barrow, Mark/0000-0002-6474-5357;
   Cortese-Krott, Miriam /0000-0002-0593-1192; Kuhnle,
   Gunter/0000-0002-8081-8931; Fernandez, Bernadette/0000-0001-6337-0381;
   Singer, Mervyn/0000-0002-1042-6350
FU German Research Council [DFG CO 1305/2-1, SFB1116 TP B06]; European
   Cooperation in Science and Technology (COST) action [BM1005]; Slovak
   Research & Development Agency [APVV-0074-11]; Marie Curie International
   Reintegration Grant [PIRG08-GA-2010-277006]; Hungarian National Science
   Foundation (OTKA) [K 109843]; Hungarian Academy of Sciences;
   Susanne-Bunnenberg-Stiftung of the Dusseldorf Heart Center; UK Medical
   Research Council [G1001536]; Faculty of Medicine, University of
   Southampton
FX We thank Peter B. O'Connor, J. Derek Woollins, Catherine Botting, and
   many other colleagues for insightful discussions and critical reading of
   our paper. The authors acknowledge support from the German Research
   Council (DFG CO 1305/2-1 to M.M.C.K., SFB1116 TP B06 to M.M.C.K. and
   M.K.); the European Cooperation in Science and Technology (COST) action
   BM1005 (European Network on Gasotransmitters) allowing M.G. to conduct
   experiments in P.N.'s laboratory; the Slovak Research & Development
   Agency (APVV-0074-11 to K.O.), the Marie Curie International
   Reintegration Grant (PIRG08-GA-2010-277006 to P.N.), the Hungarian
   National Science Foundation (OTKA; Grant K 109843 to P.N.), and the
   Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
   (to P.N.); the Susanne-Bunnenberg-Stiftung of the Dusseldorf Heart
   Center (to M.K.); the UK Medical Research Council (G1001536 to M.F.) and
   the Faculty of Medicine, University of Southampton (to M.F.).
NR 64
TC 34
Z9 37
U1 9
U2 31
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 25
PY 2015
VL 112
IS 34
BP E4651
EP E4660
DI 10.1073/pnas.1509277112
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP6NZ
UT WOS:000360005600006
PM 26224837
ER

PT J
AU Kirby, TW
   Gassman, NR
   Smith, CE
   Pedersen, LC
   Gabel, SA
   Sobhany, M
   Wilson, SH
   London, RE
AF Kirby, Thomas W.
   Gassman, Natalie R.
   Smith, Cassandra E.
   Pedersen, Lars C.
   Gabel, Scott A.
   Sobhany, Mack
   Wilson, Samuel H.
   London, Robert E.
TI Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the
   Functional Role of a Bipartite NLS
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BASE EXCISION-REPAIR; STRAND BREAK REPAIR; IMPORTIN-ALPHA; LIGASE-III;
   STRUCTURAL BASIS; POLY(ADP-RIBOSE) POLYMERASE; OXIDATIVE-STRESS;
   PROTEIN; SIGNALS; BINDING
AB We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging. Crystallography and binding studies confirm the bipartite nature of the XRCC1 NLS interaction with Importin alpha (Imp alpha) in which the major and minor binding motifs are separated by >20 residues, and resolve previous inconsistent determinations. Binding studies of peptides corresponding to the bipartite NLS, as well as its major and minor binding motifs, to both wild-type and mutated forms of Imp alpha reveal pronounced cooperative binding behavior that is generated by the proximity effect of the tethered major and minor motifs of the NLS. The cooperativity stems from the increased local concentration of the second motif near its cognate binding site that is a consequence of the stepwise binding behavior of the bipartite NLS. We predict that the stepwise dissociation of the NLS from Impa facilitates unloading by providing a partially complexed intermediate that is available for competitive binding by Nup50 or the Importin beta binding domain. This behavior provides a basis for meeting the intrinsically conflicting high affinity and high flux requirements of an efficient nuclear transport system.
C1 [Kirby, Thomas W.; Gassman, Natalie R.; Smith, Cassandra E.; Pedersen, Lars C.; Gabel, Scott A.; Sobhany, Mack; Wilson, Samuel H.; London, Robert E.] NIEHS, Genome Integr & Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP London, RE (reprint author), NIEHS, Genome Integr & Struct Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM london@niehs.nih.gov
OI Gassman, Natalie/0000-0002-8488-2332
FU Division of Intramural Research of the National Institute of
   Environmental Health Sciences, National Institutes of Health (NIH) [1ZIA
   ES050111-26, Z01-ES050158, Z01-ES050159, 1ZIA ES102645-03]; US
   Department of Energy, Office of Science, Office of Basic Energy Sciences
   [W-31-109-Eng-38];  [1K99ES023813-01]
FX This research was supported by the Division of Intramural Research of
   the National Institute of Environmental Health Sciences, National
   Institutes of Health (NIH), Project numbers: 1ZIA ES050111-26 (R.E.L.);
   Z01-ES050158 and Z01-ES050159 (S.H.W.); and 1ZIA ES102645-03 (L.C.P.).
   N.R.G. is funded by 1K99ES023813-01. Use of the Advanced Photon Source
   was supported by the US Department of Energy, Office of Science, Office
   of Basic Energy Sciences Contract W-31-109-Eng-38. The authors are
   grateful to Dr. R. Scott Williams for allowing use of the POLARstar
   Omega microplate reader, and to C. Jeff Tucker at the NIEHS Fluorescence
   Microscopy and Imaging Center for his expert assistance with imaging and
   quantification methods used in the study, and to Lois Wyrick for help
   with the figures, and to Julie Horton and Bill Beard for helpful
   comments on the manuscript.
NR 64
TC 4
Z9 4
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 25
PY 2015
VL 5
AR 13405
DI 10.1038/srep13405
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP6ZF
UT WOS:000360036300001
PM 26304019
ER

PT J
AU Fang, Q
   Indzhykulian, AA
   Mustapha, M
   Riordan, GP
   Dolan, DF
   Friedman, TB
   Belyantseva, IA
   Frolenkov, GI
   Camper, SA
   Bird, JE
AF Fang, Qing
   Indzhykulian, Artur A.
   Mustapha, Mirna
   Riordan, Gavin P.
   Dolan, David F.
   Friedman, Thomas B.
   Belyantseva, Inna A.
   Frolenkov, Gregory I.
   Camper, Sally A.
   Bird, Jonathan E.
TI The 133-kDa N-terminal domain enables myosin 15 to maintain
   mechanotransducing stereocilia and is essential for hearing
SO ELIFE
LA English
DT Article
ID HAIR-CELL STEREOCILIA; UNCONVENTIONAL MYOSIN; INNER-EAR;
   ACTIN-FILAMENTS; DEAFNESS DFNB3; MOLECULAR TREADMILL; LENGTH REGULATION;
   BIRD COCHLEA; XVA; REVEALS
AB The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical for mechanotransduction and the sense of hearing. Yet, how the lengths of actin-based stereocilia are regulated remains poorly understood. Mutations of the molecular motor myosin 15 stunt stereocilia growth and cause deafness. We found that hair cells express two isoforms of myosin 15 that differ by inclusion of an 133-kDa N-terminal domain, and that these isoforms can selectively traffic to different stereocilia rows. Using an isoform-specific knockout mouse, we show that hair cells expressing only the small isoform remarkably develop normal stereocilia bundles. However, a critical subset of stereocilia with active mechanotransducer channels subsequently retracts. The larger isoform with the 133-kDa N-terminal domain traffics to these specialized stereocilia and prevents disassembly of their actin core. Our results show that myosin 15 isoforms can navigate between functionally distinct classes of stereocilia, and are independently required to assemble and then maintain the intricate hair bundle architecture.
C1 [Fang, Qing; Mustapha, Mirna; Camper, Sally A.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
   [Indzhykulian, Artur A.; Frolenkov, Gregory I.] Univ Kentucky, Dept Physiol, Lexington, KY 40506 USA.
   [Riordan, Gavin P.; Friedman, Thomas B.; Belyantseva, Inna A.; Bird, Jonathan E.] Natl Inst Deafness & Other Commun Disorders, Lab Mol Genet, NIH, Bethesda, MD USA.
   [Dolan, David F.] Univ Michigan, Dept Otolaryngol, Sch Med, Ann Arbor, MI 48109 USA.
RP Bird, JE (reprint author), Natl Inst Deafness & Other Commun Disorders, Lab Mol Genet, NIH, Bethesda, MD USA.
EM jonathan.bird@nih.gov
OI Indzhykulian, Artur/0000-0002-2076-6818; Bird,
   Jonathan/0000-0001-5531-8794; Frolenkov, Gregory/0000-0002-9810-5024;
   Camper, Sally/0000-0001-8556-3379
FU National Institute on Deafness and Other Communication Disorders (NIDCD)
   [DC000039-18, DC000048-18, DC05053, DC008861, DC05188]; Hearing Health
   Foundation (HHF); University of Michigan (U-M)
FX National Institute on Deafness and Other Communication Disorders (NIDCD)
   DC000039-18 Thomas B Friedman, Inna A Belyantseva, Jonathan E Bird;
   National Institute on Deafness and Other Communication Disorders (NIDCD)
   DC000048-18 Thomas B Friedman, Inna A Belyantseva, Jonathan E Bird;
   Hearing Health Foundation (HHF) N/A Mirna Mustapha; University of
   Michigan (U-M) N/A Qing Fang; National Institute on Deafness and Other
   Communication Disorders (NIDCD) DC05053 Qing Fang, Artur A Indzhykulian,
   Mirna Mustapha, Gregory I Frolenkov, Sally A Camper; National Institute
   on Deafness and Other Communication Disorders (NIDCD) DC008861 Artur A
   Indzhykulian, Gregory I Frolenkov; National Institute on Deafness and
   Other Communication Disorders (NIDCD) DC05188 David F Dolan; The funders
   had no role in study design, data collection and interpretation, or the
   decision to submit the work for publication.
NR 60
TC 6
Z9 6
U1 0
U2 2
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 24
PY 2015
VL 4
AR e08627
DI 10.7554/eLife.08627
PG 22
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA DI9IR
UT WOS:000373816600001
ER

PT J
AU Coate, TM
   Spita, NA
   Zhang, KD
   Isgrig, KT
   Kelley, MW
AF Coate, Thomas M.
   Spita, Nathalie A.
   Zhang, Kaidi D.
   Isgrig, Kevin T.
   Kelley, Matthew W.
TI Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell
   innervation by spiral ganglion neurons
SO ELIFE
LA English
DT Article
ID II COCHLEAR AFFERENTS; AXON GUIDANCE; SECRETED SEMAPHORINS;
   NERVOUS-SYSTEM; NEUROPILIN-2; MOUSE; NEUROTROPHINS; EXPRESSION; EAR;
   PROJECTIONS
AB Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-lapse imaging, we visualized for the first time the behaviors of developing SGNs including active retraction of processes from OHCs, suggesting that some type I SGNs contact OHCs before forming synapses with IHCs. In addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs. These results suggest a model in which cochlear innervation patterns by type I SGNs are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes processes from extending beyond the IHC region.
C1 [Coate, Thomas M.; Isgrig, Kevin T.; Kelley, Matthew W.] Natl Inst Deafness & Other Commun Disorders, Lab Cochlear Dev, Bethesda, MD USA.
   [Coate, Thomas M.; Spita, Nathalie A.; Zhang, Kaidi D.] Georgetown Univ, Dept Biol, Washington, DC 20057 USA.
RP Coate, TM (reprint author), Natl Inst Deafness & Other Commun Disorders, Lab Cochlear Dev, Bethesda, MD USA.
EM tmc91@georgetown.edu
FU National Institute on Deafness and Other Communication Disorders (NIDCD)
   [DC13107, DC000059]
FX National Institute on Deafness and Other Communication Disorders (NIDCD)
   DC13107 Thomas M Coate; National Institute on Deafness and Other
   Communication Disorders (NIDCD) DC000059 Matthew W Kelley
NR 53
TC 4
Z9 4
U1 2
U2 3
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 24
PY 2015
VL 4
AR e07830
DI 10.7554/eLife.07830
PG 24
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA DI4AD
UT WOS:000373441500001
ER

PT J
AU Sacks, D
AF Sacks, David
TI Gateway to deLiver: How malaria sporozoites cross the sinusoidal barrier
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Editorial Material
C1 NIAID, NIH, Bethesda, MD 20892 USA.
RP Sacks, D (reprint author), NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM dsacks@nih.gov
NR 1
TC 0
Z9 0
U1 2
U2 6
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA
SN 0022-1007
EI 1540-9538
J9 J EXP MED
JI J. Exp. Med.
PD AUG 24
PY 2015
VL 212
IS 9
BP 1340
EP 1340
DI 10.1084/jem.2129insight1
PG 1
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CQ1SR
UT WOS:000360379800001
PM 26304979
ER

PT J
AU Cha, SJ
   Park, K
   Srinivasan, P
   Schindler, CW
   van Rooijen, N
   Stins, M
   Jacobs-Lorena, M
AF Cha, Sung-Jae
   Park, Kiwon
   Srinivasan, Prakash
   Schindler, Christian W.
   van Rooijen, Nico
   Stins, Monique
   Jacobs-Lorena, Marcelo
TI CD68 acts as a major gateway for malaria sporozoite liver infection
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID HEPARAN-SULFATE PROTEOGLYCANS; KUPFFER CELLS; CIRCUMSPOROZOITE PROTEIN;
   SURFACE EXPRESSION; MOSQUITO MIDGUT; MACROSIALIN; MACROPHAGES;
   HEPATOCYTES; PARASITE; INVASION
AB After being delivered by the bite from an infected mosquito, Plasmodium sporozoites enter the blood circulation and infect the liver. Previous evidence suggests that Kupffer cells, a macrophage-like component of the liver blood vessel lining, are traversed by sporozoites to initiate liver invasion. However, the molecular determinants of sporozoite-Kupffer cell interactions are unknown. Understanding the molecular basis for this specific recognition may lead to novel therapeutic strategies to control malaria. Using a phage display library screen, we identified a peptide, P39, that strongly binds to the Kupffer cell surface and, importantly, inhibits sporozoite Kupffer cell entry. Furthermore, we determined that P39 binds to CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
C1 [Cha, Sung-Jae; Park, Kiwon; Jacobs-Lorena, Marcelo] Johns Hopkins Univ, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
   [Cha, Sung-Jae; Park, Kiwon; Jacobs-Lorena, Marcelo] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Johns Hopkins Malaria Res Inst, Baltimore, MD 21205 USA.
   [Stins, Monique] Johns Hopkins Univ, Dept Neurol, Johns Hopkins Sch Med, Baltimore, MD 21205 USA.
   [Srinivasan, Prakash] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
   [Schindler, Christian W.] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA.
   [Schindler, Christian W.] Columbia Univ, Dept Med, New York, NY 10032 USA.
   [van Rooijen, Nico] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands.
RP Jacobs-Lorena, M (reprint author), Johns Hopkins Univ, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
EM mlorena@jhsph.edu
FU Johns Hopkins Malaria Research Institute; Bloomberg Family Foundation;
   National Institute of Allergy and Infectious Diseases (NIAID)
   [AI080668]; National Institutes of Health [RR00052]
FX Support from the Johns Hopkins Malaria Research Institute and the
   Bloomberg Family Foundation is gratefully acknowledged.; This work was
   supported by grant AI080668 from the National Institute of Allergy and
   Infectious Diseases (NIAID). Supply of human blood was supported by
   National Institutes of Health grant RR00052.
NR 40
TC 11
Z9 11
U1 1
U2 5
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA
SN 0022-1007
EI 1540-9538
J9 J EXP MED
JI J. Exp. Med.
PD AUG 24
PY 2015
VL 212
IS 9
BP 1391
EP 1403
DI 10.1084/jem.20110575
PG 13
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CQ1SR
UT WOS:000360379800009
PM 26216124
ER

PT J
AU Rogena, EA
   Simbiri, KO
   De Falco, G
   Leoncini, L
   Ayers, L
   Nyagol, J
AF Rogena, Emily A.
   Simbiri, Kenneth O.
   De Falco, G.
   Leoncini, L.
   Ayers, Leona
   Nyagol, J.
TI A review of the pattern of AIDS defining, HIV associated neoplasms and
   premalignant lesions diagnosed from 2000-2011 at Kenyatta National
   Hospital, Kenya
SO INFECTIOUS AGENTS AND CANCER
LA English
DT Review
ID RESOURCE-LIMITED SETTINGS; KAPOSIS-SARCOMA; AFRICA; INFECTION; CANCER;
   EPIDEMIOLOGY; MALIGNANCIES; COUNTRIES; LYMPHOMAS; UGANDA
AB Background: Sub-Sahara Africa hosts up to 71 % of all HIV infected people in the world. With this high incidence of Human immunodeficiency virus (HIV) comes the burden of co-morbidities such as malignant and premalignant lesions. Aids defining malignancies have been listed as Kaposi's sarcoma, Non-Hodgkin's lymphoma and invasive squamous cell carcinoma of the cervix. People with HIV/AIDS(PLWAS) have a higher risk of developing these neoplasms than the rest of the population. The pathogenesis of these neoplasms in people with HIV has been linked to immune suppression, persistent antigenic stimulation and cytokine dysregulation.
   Current study analyzes and presents the patterns and trends in the presentation of HIV related malignancies in patients diagnosed through histopathology at Kenyatta National Hospital.
   Aim: To describe the patterns of AIDS-defining and non-AIDS-defining malignancies and premalignant lesions 10 years pre- and post HAART period at Kenyatta National hospital, Kenya.
   Methods and techniques: This was a hospital based descriptive cross sectional study. The Formalin fixed paraffin embedded (FFPE) blocks and histological reports of patients diagnosed between 2000 and 2011 were traced from archives. The patients' demographic data and clinical presentation was entered in an excel spreadsheet and the diagnosis and coding confirmed by a histopathologist. The data was then cleaned and analyzed using SSPS version 17.0 Ink.
   Results: A total of 173 lesions were reviewed and analyzed. Of these 118 (68 %) were from females and 55 from males (32 %). The male to female ratio was 1:2. The age range was from two to 56 years with a median of 36 years. Kaposi sarcoma is the leading AIDS defining malignancy in Kenya while invasive squamous cell carcinoma of the conjunctiva is the leading non-AIDS defining malignancy. This is closely followed by invasive squamous cell carcinoma of the cervix and NHL.
   Conclusion: Kaposi sarcoma is the leading AIDS associated neoplasm in Kenya. Physicians and caretakers managing and following up on HIV/AIDS patients should look out for Kaposi sarcoma as a form of IRIS following the institution of HAART in all HIV/AIDS patients. The incidence of invasive squamous cell carcinoma of the conjunctiva is increasing in PLWAS in Kenya. There is therefore a need to introduce early screening programs for squamous intraepithelial neoplasm of the conjunctiva in HIV/AIDS patients.
C1 [Rogena, Emily A.] Univ Nairobi, Coll Hlth Sci, Dept Human pathol, Themat Unit Anat pathol, Nairobi 00200, Kenya.
   [Simbiri, Kenneth O.] SUNY Upstate Med Univ, Dept Microbiol & Immunol, New York, NY USA.
   [De Falco, G.] Queen Mary Univ London, Sch Biol & Chem Sci, London, England.
   [Leoncini, L.] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy.
   [Ayers, Leona] Ohio State Univ, NCI, Mid Reg AIDS Canc Specimen Resource, Columbus, OH 43240 USA.
   [Nyagol, J.] Univ Nairobi, Coll Hlth Sci, Dept Human Pathol, Themat Unit Immunol, Nairobi 00202, Kenya.
RP Rogena, EA (reprint author), Univ Nairobi, Coll Hlth Sci, Dept Human pathol, Themat Unit Anat pathol, KNH CAMPUS,POB 55050, Nairobi 00200, Kenya.
EM rogena.emily@gmail.com
FU NIH; OSU (of Mid region ACSR); AIDS and Cancer Specimen Resource (ACSR)
   of the National Cancer Institute (NCI) AIDS Malignancy Program
FX We sincerely acknowledge the NIH and OSU (of Mid region ACSR) for
   funding the ACSRK, a tissue archive project from where this data has
   been obtained. The AIDS and Cancer Specimen Resource (ACSR) of the
   National Cancer Institute (NCI) AIDS Malignancy Program provides
   HIV/AIDS-related malignant tissues and data to funded/approved cancer
   researchers to promote a global understanding of the relationships
   between HIV infection and certain cancers. The ACSR Kenya is situated at
   the department of Human Pathology, University if Nairobi, and was
   started as an affiliate of OSU in 2009 and is guided by NCI Best
   Practices for Bio-specimen Resources. The site has a principal task of
   collecting, enhancing, storing, and distributing HIV related, quality
   assured human tumor tissue with associated clinical, pathological,
   visual and demographic data to approved investigators. <SUP>8</SUP>We
   hope that with improved quality of the specimens and availability of
   data, there will be an increase in translational research in area of
   HIV/AIDS-related malignancies from developing countries such as Kenya.
   We also envisage that the research and publications will contribute to
   control and management of HIV/AIDS and support the area of targeted
   therapies in cancer in general.
NR 28
TC 2
Z9 2
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1750-9378
J9 INFECT AGENTS CANCER
JI Infect. Agents Cancer
PD AUG 24
PY 2015
VL 10
AR 28
DI 10.1186/s13027-015-0021-1
PG 7
WC Oncology; Immunology
SC Oncology; Immunology
GA CP5NU
UT WOS:000359930200001
PM 26306097
ER

PT J
AU Grossman, Z
   Avidor, B
   Mor, Z
   Chowers, M
   Levy, I
   Shahar, E
   Riesenberg, K
   Sthoeger, Z
   Maayan, S
   Shao, W
   Lorber, M
   Olstein-Pops, K
   Elbirt, D
   Elinav, H
   Asher, I
   Averbuch, D
   Istomin, V
   Gottesman, BS
   Kedem, E
   Girshengorn, S
   Kra-Oz, Z
   Avni, YS
   Sade, SR
   Turner, D
   Maldarelli, F
AF Grossman, Zehava
   Avidor, Boaz
   Mor, Zohar
   Chowers, Michal
   Levy, Itzchak
   Shahar, Eduardo
   Riesenberg, Klaris
   Sthoeger, Zev
   Maayan, Shlomo
   Shao, Wei
   Lorber, Margalit
   Olstein-Pops, Karen
   Elbirt, Daniel
   Elinav, Hila
   Asher, Ilan
   Averbuch, Diana
   Istomin, Valery
   Gottesman, Bat Sheva
   Kedem, Eynat
   Girshengorn, Shirley
   Kra-Oz, Zipi
   Avni, Yonat Shemer
   Sade, Sara Radian
   Turner, Dan
   Maldarelli, Frank
TI A Population-Structured HIV Epidemic in Israel: Roles of Risk and
   Ethnicity
SO PLOS ONE
LA English
DT Article
ID REVERSE-TRANSCRIPTASE; PROTEASE; INFECTION; SUBTYPE; EUROPE; ADULT; SEX;
   MEN
AB Background
   HIV in Israel started with a subtype-B epidemic among men who have sex with men, followed in the 1980s and 1990s by introductions of subtype C from Ethiopia (predominantly acquired by heterosexual transmission) and subtype A from the former Soviet Union (FSU, most often acquired by intravenous drug use). The epidemic matured over the last 15 years without additional large influx of exogenous infections. Between 2005 and 2013 the number of infected men who have sex with men (MSM) increased 2.9-fold, compared to 1.6-fold and 1.3-fold for intravenous drug users (IVDU) and Ethiopian-origin residents. Understanding contemporary spread is essential for effective public health planning.
   Methods
   We analyzed demographic and virologic data from 1,427 HIV-infected individuals diagnosed with HIV-I during 1998-2012. HIV phylogenies were reconstructed with maximum-likelihood and Bayesian methods.
   Results
   Subtype-B viruses, but not A or C, demonstrated a striking number of large clusters with common ancestors having posterior probability >= 0.95, including some suggesting presence of transmission networks. Transmitted drug resistance was highest in subtype B (13%). MSM represented a frequent risk factor in cross-ethnic transmission, demonstrated by the presence of Israeli-born with non-B virus infections and FSU immigrants with non-A subtypes.
   Conclusions
   Reconstructed phylogenetic trees demonstrated substantial grouping in subtype B, but not in non-MSM subtype-A or in subtype-C, reflecting differences in transmission dynamics linked to HIV transmission categories. Cross-ethnic spread occurred through multiple independent introductions, with MSM playing a prevalent role in the transmission of the virus. Such data provide a baseline to track epidemic trends and will be useful in informing and quantifying efforts to reduce HIV transmission.
C1 [Grossman, Zehava] Tel Aviv Univ, Sch Publ Hlth, IL-69978 Tel Aviv, Israel.
   [Grossman, Zehava; Maldarelli, Frank] NCI, Frederick, MD 21701 USA.
   [Avidor, Boaz; Girshengorn, Shirley; Turner, Dan] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Crusaid Kobler AIDS Ctr, IL-69978 Tel Aviv, Israel.
   [Avidor, Boaz; Girshengorn, Shirley] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Lab Viruses & Mol Biol, IL-69978 Tel Aviv, Israel.
   [Mor, Zohar] Minist Hlth, Ramla Dept Hlth, Ramla, Israel.
   [Chowers, Michal; Gottesman, Bat Sheva] Meir Med Ctr, Kefar Sava, Israel.
   [Levy, Itzchak] Chaim Sheba Med Ctr, Infect Dis Unit, Ramat Gan, Israel.
   [Shahar, Eduardo; Lorber, Margalit; Kedem, Eynat; Kra-Oz, Zipi] Rambam Med Ctr, Haifa, Israel.
   [Riesenberg, Klaris; Avni, Yonat Shemer] Soroka Med Ctr, IL-84101 Beer Sheva, Israel.
   [Sthoeger, Zev; Elbirt, Daniel; Asher, Ilan; Sade, Sara Radian] Kaplan Med Ctr, Rehovot, Israel.
   [Maayan, Shlomo; Olstein-Pops, Karen; Elinav, Hila; Averbuch, Diana] Hadassah Med Ctr, IL-91120 Jerusalem, Israel.
   [Shao, Wei] SAIC Frederick Inc, Adv Biomed Comp Ctr, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
   [Istomin, Valery] Hillel Yaffe Med Ctr, Hadera, Israel.
RP Grossman, Z (reprint author), Tel Aviv Univ, Sch Publ Hlth, IL-69978 Tel Aviv, Israel.
EM Zehava.Grossman@gmail.com
OI Chowers, Michal/0000-0001-6148-254X
FU European Commission [LSHP-CT-2006-518211]; NIH
FX This work was supported in part by a European Commission, Grant number
   LSHP-CT-2006-518211 (ZG) and by a NIH Bench to Bedside Grant (FM). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
NR 37
TC 4
Z9 4
U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 24
PY 2015
VL 10
IS 8
AR e0135061
DI 10.1371/journal.pone.0135061
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP5VA
UT WOS:000359951900013
PM 26302493
ER

PT J
AU Zhao, BM
   Keasey, SL
   Tropea, JE
   Lountos, GT
   Dyas, BK
   Cherry, S
   Raran-Kurussi, S
   Waugh, DS
   Ulrich, RG
AF Zhao, Bryan M.
   Keasey, Sarah L.
   Tropea, Joseph E.
   Lountos, George T.
   Dyas, Beverly K.
   Cherry, Scott
   Raran-Kurussi, Sreejith
   Waugh, David S.
   Ulrich, Robert G.
TI Phosphotyrosine Substrate Sequence Motifs for Dual Specificity
   Phosphatases
SO PLOS ONE
LA English
DT Article
ID PROTEIN-TYROSINE PHOSPHATASES; CELL LUNG-CANCER; CRYSTAL-STRUCTURE;
   KINASE PHOSPHATASE-1; CATALYTIC MECHANISM; ANGSTROM RESOLUTION; CDC25
   PHOSPHATASE; ACTIVATION; INHIBITORS; VIRUS
AB Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P) residues of proteins. The DUSPs are linked to the regulation of many cellular functions and signaling pathways. Though many cellular targets of DUSPs are known, the relationship between catalytic activity and substrate specificity is poorly defined. We investigated the interactions of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C). Phosphatase recognition sites were experimentally determined by measuring dephosphorylation of 6,218 microarrayed Tyr(P) peptides representing confirmed and theoretical phosphorylation motifs from the cellular proteome. A broad continuum of dephosphorylation was observed across the microarrayed peptide substrates for all phosphatases, suggesting a complex relationship between substrate sequence recognition and optimal activity. Further analysis of peptide dephosphorylation by hierarchical clustering indicated that DUSPs could be organized by substrate sequence motifs, and peptide-specificities by phylogenetic relationships among the catalytic domains. The most highly dephosphorylated peptides represented proteins from 29 cell-signaling pathways, greatly expanding the list of potential targets of DUSPs. These newly identified DUSP substrates will be important for examining structure-activity relationships with physiologically relevant targets.
C1 [Zhao, Bryan M.; Keasey, Sarah L.; Dyas, Beverly K.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
   [Zhao, Bryan M.] Geneva Fdn, Tacoma, WA 98402 USA.
   [Tropea, Joseph E.; Lountos, George T.; Cherry, Scott; Raran-Kurussi, Sreejith; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, Frederick, MD 21702 USA.
   [Lountos, George T.] Leidos Biomed Res Inc, Basic Sci Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
RP Ulrich, RG (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU Geneva Foundation; Leidos Biomedical Research, Inc.
FX The Geneva Foundation and Leidos Biomedical Research, Inc. provided
   support in the form of salaries for authors BMZ and GTL, respectively,
   but did not have any additional role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. The specific roles of these authors are articulated in the
   'author contributions' section
NR 61
TC 2
Z9 2
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 24
PY 2015
VL 10
IS 8
AR e0134984
DI 10.1371/journal.pone.0134984
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP5VA
UT WOS:000359951900010
PM 26302245
ER

PT J
AU Quevillon, LE
   Hanks, EM
   Bansal, S
   Hughes, DP
AF Quevillon, Lauren E.
   Hanks, Ephraim M.
   Bansal, Shweta
   Hughes, David P.
TI Social, spatial, and temporal organization in a complex insect society
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TRANSMISSION DYNAMICS; DISEASE TRANSMISSION; COLONY ORGANIZATION;
   HONEY-BEES; IMMUNITY; NETWORKS; ANTS; PATHOGEN; TRACKING; BEHAVIOR
AB High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and inducible defenses termed 'collective immunity'. Here we characterise segregation of carpenter ants that would be most likely to encounter infectious agents (i.e. foragers) using integrated social, spatial, and temporal analyses. Importantly, we do this in the absence of disease to establish baseline colony organization. Behavioural and social network analyses show that active foragers engage in more trophallaxis interactions than their nest worker and queen counterparts and occupy greater area within the nest. When the temporal ordering of social interactions is taken into account, active foragers and inactive foragers are not observed to interact with the queen in ways that could lead to the meaningful transfer of disease. Furthermore, theoretical resource spread analyses show that such temporal segregation does not appear to impact the colony-wide flow of food. This study provides an understanding of a complex society's organization in the absence of disease that will serve as a null model for future studies in which disease is explicitly introduced.
C1 [Quevillon, Lauren E.; Hanks, Ephraim M.; Hughes, David P.] Penn State Univ, Ctr Infect Dis Dynam, University Pk, PA 16802 USA.
   [Quevillon, Lauren E.; Hughes, David P.] Penn State Univ, Dept Biol, University Pk, PA 16802 USA.
   [Hanks, Ephraim M.] Penn State Univ, Dept Stat, University Pk, PA 16802 USA.
   [Bansal, Shweta] Georgetown Univ, Dept Biol, Washington, DC 20057 USA.
   [Bansal, Shweta] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Hughes, David P.] Penn State Univ, Dept Entomol, University Pk, PA 16802 USA.
RP Quevillon, LE (reprint author), Penn State Univ, Ctr Infect Dis Dynam, University Pk, PA 16802 USA.
EM leq103@psu.edu; dph14@psu.edu
OI Bansal, Shweta/0000-0002-1740-5421
FU NSF [DGE1255832]; NSF, joint NSF-NIH-USDA Ecology and Evolution of
   Infectious Diseases program [1414296]
FX We are grateful to the many undergraduate assistants in the Hughes Lab
   that helped in data collection, particularly Mike Wesolowski and Joanne
   Collins. L.E.Q. is supported by a NSF Graduate Research Fellowship under
   Grant No. DGE1255832. This work was funded by NSF Grant No. 1414296 as
   part of the joint NSF-NIH-USDA Ecology and Evolution of Infectious
   Diseases program. Any opinions, findings, and conclusions or
   recommendations expressed in this material are those of the authors and
   do not necessarily reflect the views of the National Science Foundation.
NR 56
TC 3
Z9 3
U1 8
U2 51
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 24
PY 2015
VL 5
AR 13393
DI 10.1038/srep13393
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP5OG
UT WOS:000359931700001
PM 26300390
ER

PT J
AU Vos, T
   Barber, RM
   Bell, B
   Bertozzi-Villa, A
   Biryukov, S
   Bolliger, I
   Charlson, F
   Davis, A
   Degenhardt, L
   Dicker, D
   Duan, L
   Erskine, H
   Feigin, VL
   Ferrari, AJ
   Fitzmaurice, C
   Fleming, T
   Graetz, N
   Guinovart, C
   Haagsma, J
   Hansen, GM
   Hanson, SW
   Heuton, KR
   Higashi, H
   Kassebaum, N
   Kyu, H
   Laurie, E
   Liang, XF
   Lofgren, K
   Lozano, R
   MacIntyre, MF
   Moradi-Lakeh, M
   Naghavi, M
   Nguyen, G
   Odell, S
   Ortblad, K
   Roberts, DA
   Roth, GA
   Sandar, L
   Serina, PT
   Stanaway, JD
   Steiner, C
   Thomas, B
   Vollset, SE
   Whiteford, H
   Wolock, TM
   Ye, PP
   Zhou, MG
   Avila, MA
   Aasvang, GM
   Abbafati, C
   Ozgoren, AA
   Abd-Allah, F
   Aziz, MIA
   Abera, SF
   Aboyans, V
   Abraham, JP
   Abraham, B
   Abubakar, I
   Abu-Raddad, LJ
   Abu-Rmeileh, NME
   Aburto, TC
   Achoki, T
   Ackerman, IN
   Adelekan, A
   Ademi, Z
   Adou, AK
   Adsuar, JC
   Arnlov, J
   Agardh, EE
   Al Khabouri, MJ
   Alam, SS
   Alasfoor, D
   Albittar, MI
   Alegretti, MA
   Aleman, AV
   Alemu, ZA
   Alfonso-Cristancho, R
   Alhabib, S
   Ali, R
   Alla, F
   Allebeck, P
   Allen, PJ
   AlMazroa, MA
   Alsharif, U
   Alvarez, E
   Alvis-Guzman, N
   Ameli, O
   Amini, H
   Ammar, W
   Anderson, BO
   Anderson, HR
   Antonio, CAT
   Anwari, P
   Apfel, H
   Arsenijevic, VSA
   Artaman, A
   Asghar, RJ
   Assadi, R
   Atkins, LS
   Atkinson, C
   Badawi, A
   Bahit, MC
   Bakfalouni, T
   Balakrishnan, K
   Balalla, S
   Banerjee, A
   Barker-Collo, SL
   Barquera, S
   Barregard, L
   Barrero, LH
   Basu, S
   Basu, A
   Baxter, A
   Beardsley, J
   Bedi, N
   Beghi, E
   Bekele, T
   Bell, ML
   Benjet, C
   Bennett, DA
   Bensenor, IM
   Benzian, H
   Bernabe, E
   Beyene, TJ
   Bhala, N
   Bhalla, A
   Bhutta, ZQ
   Bienhoff, K
   Bikbov, B
   Bin Abdulhak, A
   Blore, JD
   Blyth, FM
   Bohensky, MA
   Basara, BB
   Borges, G
   Bornstein, NM
   Bose, D
   Boufous, S
   Bourne, RR
   Boyers, LN
   Brainin, M
   Brauer, M
   Brayne, CEG
   Brazinova, A
   Breitborde, NJK
   Brenner, H
   Briggs, ADM
   Brooks, PM
   Brown, J
   Brugha, TS
   Buchbinder, R
   Buckle, GC
   Bukhman, G
   Bulloch, AG
   Burch, M
   Burnett, R
   Cardenas, R
   Cabral, NL
   Nonato, IRC
   Campuzano, JC
   Carapetis, JR
   Carpenter, DO
   Caso, V
   Castaneda-Orjuela, CA
   Catala-Lopez, F
   Chadha, VK
   Chang, JC
   Chen, HL
   Chen, WQ
   Chiang, PP
   Chimed-Ochir, O
   Chowdhury, R
   Christensen, H
   Christophi, CA
   Chugh, SS
   Cirillo, M
   Coggeshall, M
   Cohen, A
   Colistro, V
   Colquhoun, SM
   Contreras, AG
   Cooper, LT
   Cooper, C
   Cooperrider, K
   Coresh, J
   Cortinovis, M
   Criqui, MH
   Crump, JA
   Cuevas-Nasu, L
   Dandona, R
   Dandona, L
   Dansereau, E
   Dantes, HG
   Dargan, PI
   Davey, G
   Davitoiu, DV
   Dayama, A
   De la Cruz-Gongora, V
   de la Vega, SF
   De Leo, D
   del Pozo-Cruz, B
   Dellavalle, RP
   Deribe, K
   Derrett, S
   Des Jarlais, DC
   Dessalegn, M
   de Veber, GA
   Dharmaratne, SD
   Diaz-Torne, C
   Ding, EL
   Dokova, K
   Dorsey, ER
   Driscoll, TR
   Duber, H
   Durrani, AM
   Edmond, KM
   Ellenbogen, RG
   Endres, M
   Ermakov, SP
   Eshrati, B
   Esteghamati, A
   Estep, K
   Fahimi, S
   Farzadfar, F
   Fay, DFJ
   Felson, DT
   Fereshtehnejad, SM
   Fernandes, JG
   Ferri, CP
   Flaxman, A
   Foigt, N
   Foreman, KJ
   Fowkes, FGR
   Franklin, RC
   Furst, T
   Futran, ND
   Gabbe, BJ
   Gankpe, FG
   Garcia-Guerra, FA
   Geleijnse, JM
   Gessner, BD
   Gibney, KB
   Gillum, RF
   Ginawi, IA
   Giroud, M
   Giussani, G
   Goenka, S
   Goginashvili, K
   Gona, P
   de Cosio, TG
   Gosselin, RA
   Gotay, CC
   Goto, A
   Gouda, HN
   Guerrant, RL
   Gugnani, HC
   Gunnell, D
   Gupta, R
   Gupta, R
   Gutierrez, RA
   Hafezi-Nejad, N
   Hagan, H
   Halasa, Y
   Hamadeh, RR
   Hamavid, H
   Hammami, M
   Hankey, GJ
   Hao, YT
   Harb, HL
   Haro, JM
   Havmoeller, R
   Hay, RJ
   Hay, S
   Hedayati, MT
   Pi, IBH
   Heydarpour, P
   Hijar, M
   Hoek, HW
   Hoffman, HJ
   Hornberger, JC
   Hosgood, HD
   Hossain, M
   Hotez, PJ
   Hoy, DG
   Hsairi, M
   Hu, H
   Hu, GQ
   Huang, JJ
   Huang, C
   Huiart, L
   Husseini, A
   Iannarone, M
   Iburg, KM
   Innos, K
   Inoue, M
   Jacobsen, KH
   Jassal, SK
   Jeemon, P
   Jensen, PN
   Jha, V
   Jiang, G
   Jiang, Y
   Jonas, JB
   Joseph, J
   Juel, K
   Kan, HD
   Karch, A
   Karimkhani, C
   Karthikeyan, G
   Katz, R
   Kaul, A
   Kawakami, N
   Kazi, DS
   Kemp, AH
   Kengne, AP
   Khader, YS
   Khalifa, SEAH
   Khan, EA
   Khan, G
   Khang, YH
   Khonelidze, I
   Kieling, C
   Kim, D
   Kim, S
   Kimokoti, RW
   Kinfu, Y
   Kinge, JM
   Kissela, BM
   Kivipelto, M
   Knibbs, L
   Knudsen, AK
   Kokubo, Y
   Kosen, S
   Kramer, A
   Kravchenko, M
   Krishnamurthi, RV
   Krishnaswami, S
   Defo, BK
   Bicer, BK
   Kuipers, EJ
   Kulkarni, VS
   Kumar, K
   Kumar, GA
   Kwan, GF
   Lai, T
   Lalloo, R
   Lam, H
   Lan, Q
   Lansingh, VC
   Larson, H
   Larsson, A
   Lawrynowicz, AEB
   Leasher, JL
   Lee, JT
   Leigh, J
   Leung, R
   Levi, M
   Li, B
   Li, YC
   Li, YM
   Liang, J
   Lim, S
   Lin, HH
   Lind, M
   Lindsay, MP
   Lipshultz, SE
   Liu, SW
   Lloyd, BK
   Ohno, SL
   Logroscino, G
   Looker, KJ
   Lopez, AD
   Lopez-Olmedo, N
   Lortet-Tieulent, J
   Lotufo, PA
   Low, N
   Lucas, RM
   Lunevicius, R
   Lyons, RA
   Ma, JX
   Ma, S
   Mackay, MT
   Majdan, M
   Malekzadeh, R
   Mapoma, CC
   Marcenes, W
   March, LM
   Margono, C
   Marks, GB
   Marzan, MB
   Masci, JR
   Mason-Jones, AJ
   Matzopoulos, RG
   Mayosi, BM
   Mazorodze, TT
   McGill, NW
   McGrath, JJ
   McKee, M
   McLain, A
   McMahon, BJ
   Meaney, PA
   Mehndiratta, MM
   Mejia-Rodriguez, F
   Mekonnen, W
   Melaku, YA
   Meltzer, M
   Memish, ZA
   Mensah, G
   Meretoja, A
   Mhimbira, FA
   Micha, R
   Miller, TR
   Mills, EJ
   Mitchell, PB
   Mock, CN
   Moffitt, TE
   Ibrahim, NM
   Mohammad, KA
   Mokdad, AH
   Mola, GL
   Monasta, L
   Montico, M
   Montine, TJ
   Moore, AR
   Moran, AE
   Morawska, L
   Mori, R
   Moschandreas, J
   Moturi, WN
   Moyer, M
   Mozaffarian, D
   Mueller, UO
   Mukaigawara, M
   Murdoch, ME
   Murray, J
   Murthy, KS
   Naghavi, P
   Nahas, Z
   Naheed, A
   Naidoo, KS
   Naldi, L
   Nand, D
   Nangia, V
   Narayan, KMV
   Nash, D
   Nejjari, C
   Neupane, SP
   Newman, LM
   Newton, CR
   Ng, M
   Ngalesoni, FN
   Nhung, NT
   Nisar, MI
   Nolte, S
   Norheim, OF
   Norman, RE
   Norrving, B
   Nyakarahuka, L
   Oh, IH
   Ohkubo, T
   Omer, SB
   Opio, JN
   Ortiz, A
   Pandian, JD
   Panelo, CIA
   Papachristou, C
   Park, EK
   Parry, CD
   Caicedo, AJP
   Patten, SB
   Paul, VK
   Pavlin, BI
   Pearce, N
   Pedraza, LS
   Pellegrini, CA
   Pereira, DM
   Perez-Ruiz, FP
   Perico, N
   Pervaiz, A
   Pesudovs, K
   Peterson, CB
   Petzold, M
   Phillips, MR
   Phillips, D
   Phillips, B
   Piel, FB
   Plass, D
   Poenaru, D
   Polanczyk, GV
   Polinder, S
   Pope, CA
   Popova, S
   Poulton, RG
   Pourmalek, F
   Prabhakaran, D
   Prasad, NM
   Qato, D
   Quistberg, DA
   Rafay, A
   Rahimi, K
   Rahimi-Movaghar, V
   Rahman, SU
   Raju, M
   Rakovac, I
   Rana, SM
   Razavi, H
   Refaat, A
   Rehm, J
   Remuzzi, G
   Resnikoff, S
   Ribeiro, AL
   Riccio, PM
   Richardson, L
   Richardus, JH
   Riederer, AM
   Robinson, M
   Roca, A
   Rodriguez, A
   Rojas-Rueda, D
   Ronfani, L
   Rothenbacher, D
   Roy, N
   Ruhago, GM
   Sabin, N
   Sacco, RL
   Ksoreide, K
   Saha, S
   Sahathevan, R
   Sahraian, MA
   Sampson, U
   Sanabria, JR
   Sanchez-Riera, L
   Santos, IS
   Satpathy, M
   Saunders, JE
   Sawhney, M
   Saylan, MI
   Scarborough, P
   Schoettker, B
   Schneider, IJ
   Schwebel, DC
   Scott, JG
   Seedat, S
   Sepanlou, SG
   Serdar, B
   Servan-Mori, EE
   Shackelford, K
   Shaheen, A
   Shahraz, S
   Levy, TS
   Shangguan, S
   She, J
   Sheikhbahaei, S
   Shepard, DS
   Shi, PL
   Shibuya, K
   Shinohara, Y
   Shiri, R
   Shishani, K
   Shiue, I
   Shrime, MG
   Sigfusdottir, ID
   Silberberg, DH
   Simard, EP
   Sindi, S
   Singh, JA
   Singh, L
   Skirbekk, V
   Sliwa, K
   Soljak, M
   Soneji, S
   Soshnikov, SS
   Speyer, P
   Sposato, LA
   Sreeramareddy, CT
   Stoeckl, H
   Stathopoulou, VK
   Steckling, N
   Stein, MB
   Stein, DJ
   Steiner, TJ
   Stewart, A
   Stork, E
   Stovner, LJ
   Stroumpoulis, K
   Sturua, L
   Sunguya, BF
   Swaroop, M
   Sykes, BL
   Tabb, KM
   Takahashi, K
   Tan, F
   Tandon, N
   Tanne, D
   Tanner, M
   Tavakkoli, M
   Taylor, HR
   Ao, BJT
   Temesgen, AM
   Ten Have, M
   Tenkorang, EY
   Terkawi, AS
   Theadom, AM
   Thomas, E
   Thorne-Lyman, AL
   Thrift, AG
   Tleyjeh, IM
   Tonelli, M
   Topouzis, F
   Towbin, JA
   Toyoshima, H
   Traebert, J
   Tran, BX
   Trasande, L
   Trillini, M
   Truelsen, T
   Trujillo, U
   Tsilimbaris, M
   Tuzcu, EM
   Ukwaja, KN
   Undurraga, EA
   Uzun, SB
   van Brakel, WH
   de Vijver, SV
   Van Dingenen, R
   van Gool, CH
   Varakin, YY
   Vasankari, TJ
   Vavilala, MS
   Veerman, LJ
   Velasquez-Melendez, G
   Venketasubramanian, N
   Vijayakumar, L
   Villalpando, S
   Violante, FS
   Vlassov, VV
   Waller, S
   Wallin, MT
   Wan, X
   Wang, LH
   Wang, JL
   Wang, YP
   Warouw, TS
   Weichenthal, S
   Weiderpass, E
   Weintraub, RG
   Werdecker, A
   Wessells, KRR
   Westerman, R
   Wilkinson, JD
   Williams, HC
   Williams, TN
   Woldeyohannes, SM
   Wolfe, CDA
   Wong, JQ
   Wong, HD
   Woolf, AD
   Wright, JL
   Wurtz, B
   Xu, GL
   Yang, GH
   Yano, Y
   Yenesew, MA
   Yentur, GK
   Yip, P
   Yonemoto, N
   Yoon, SJ
   Younis, M
   Yu, CH
   Kim, KY
   Zaki, MES
   Zhang, Y
   Zhao, Z
   Zhao, Y
   Zhu, J
   Zonies, D
   Zunt, JR
   Salomon, JA
   Murray, CJL
AF Vos, Theo
   Barber, Ryan M.
   Bell, Brad
   Bertozzi-Villa, Amelia
   Biryukov, Stan
   Bolliger, Ian
   Charlson, Fiona
   Davis, Adrian
   Degenhardt, Louisa
   Dicker, Daniel
   Duan, Leilei
   Erskine, Holly
   Feigin, Valery L.
   Ferrari, Alize J.
   Fitzmaurice, Christina
   Fleming, Thomas
   Graetz, Nicholas
   Guinovart, Caterina
   Haagsma, Juanita
   Hansen, Gillian M.
   Hanson, Sarah Wulf
   Heuton, Kyle R.
   Higashi, Hideki
   Kassebaum, Nicholas
   Kyu, Hmwe
   Laurie, Evan
   Liang, Xiofeng
   Lofgren, Katherine
   Lozano, Rafael
   MacIntyre, Michael F.
   Moradi-Lakeh, Maziar
   Naghavi, Mohsen
   Nguyen, Grant
   Odell, Shaun
   Ortblad, Katrina
   Roberts, David Allen
   Roth, Gregory A.
   Sandar, Logan
   Serina, Peter T.
   Stanaway, Jeffrey D.
   Steiner, Caitlyn
   Thomas, Bernadette
   Vollset, Stein Emil
   Whiteford, Harvey
   Wolock, Timothy M.
   Ye, Pengpeng
   Zhou, Maigeng
   Avila, Marco A.
   Aasvang, Gunn Marit
   Abbafati, Cristiana
   Ozgoren, Ayse Abbasoglu
   Abd-Allah, Foad
   Aziz, Muna I. Abdel
   Abera, Semaw F.
   Aboyans, Victor
   Abraham, Jerry P.
   Abraham, Biju
   Abubakar, Ibrahim
   Abu-Raddad, Laith J.
   Abu-Rmeileh, Niveen M. E.
   Aburto, Tania C.
   Achoki, Tom
   Ackerman, Ilana N.
   Adelekan, Ademola
   Ademi, Zanfina
   Adou, Arsene K.
   Adsuar, Josef C.
   Arnlov, Johan
   Agardh, Emilie E.
   Al Khabouri, Mazin J.
   Alam, Sayed Saidul
   Alasfoor, Deena
   Albittar, Mohammed I.
   Alegretti, Miguel A.
   Aleman, Alicia V.
   Alemu, Zewdie A.
   Alfonso-Cristancho, Rafael
   Alhabib, Samia
   Ali, Raghib
   Alla, Francois
   Allebeck, Peter
   Allen, Peter J.
   AlMazroa, Mohammad AbdulAziz
   Alsharif, Ubai
   Alvarez, Elena
   Alvis-Guzman, Nelson
   Ameli, Omid
   Amini, Heresh
   Ammar, Walid
   Anderson, Benjamin O.
   Anderson, H. Ross
   Antonio, Carl Abelardo T.
   Anwari, Palwasha
   Apfel, Henry
   Arsenijevic, Valentain S. Arsic
   Artaman, Al
   Asghar, Rana J.
   Assadi, Reza
   Atkins, Lydia S.
   Atkinson, Charles
   Badawi, Alaa
   Bahit, Maria C.
   Bakfalouni, Talal
   Balakrishnan, Kalpana
   Balalla, Shivanthi
   Banerjee, Amitava
   Barker-Collo, Suzanne L.
   Barquera, Simon
   Barregard, Lars
   Barrero, Lope H.
   Basu, Sanjay
   Basu, Arindam
   Baxter, Amanda
   Beardsley, Justin
   Bedi, Neeraj
   Beghi, Ettore
   Bekele, Tolesa
   Bell, Michelle L.
   Benjet, Corina
   Bennett, Derrick A.
   Bensenor, Isabela M.
   Benzian, Habib
   Bernabe, Eduardo
   Beyene, Tariku J.
   Bhala, Neeraj
   Bhalla, Ashish
   Bhutta, Zulfi Qar
   Bienhoff, Kelly
   Bikbov, Boris
   Bin Abdulhak, Aref
   Blore, Jed D.
   Blyth, Fiona M.
   Bohensky, Megan A.
   Basara, Berrak Bora
   Borges, Guilherme
   Bornstein, Natan M.
   Bose, Dipan
   Boufous, Soufiane
   Bourne, Rupert R.
   Boyers, Lindsay N.
   Brainin, Michael
   Brauer, Michael
   Brayne, Carol E. G.
   Brazinova, Alexandra
   Breitborde, Nicholas J. K.
   Brenner, Hermann
   Briggs, Adam D. M.
   Brooks, Peter M.
   Brown, Jonathan
   Brugha, Traolach S.
   Buchbinder, Rachelle
   Buckle, Geoffrey C.
   Bukhman, Gene
   Bulloch, Andrew G.
   Burch, Michael
   Burnett, Richard
   Cardenas, Rosario
   Cabral, Norberto L.
   Nonato, Ismael R. Campos
   Campuzano, Julio C.
   Carapetis, Jonathan R.
   Carpenter, David O.
   Caso, Valeria
   Castaneda-Orjuela, Carlos A.
   Catala-Lopez, Ferran
   Chadha, Vineet K.
   Chang, Jung-Chen
   Chen, Honglei
   Chen, Wanqing
   Chiang, Peggy P.
   Chimed-Ochir, Odgerel
   Chowdhury, Rajiv
   Christensen, Hanne
   Christophi, Costas A.
   Chugh, Sumeet S.
   Cirillo, Massimo
   Coggeshall, Megan
   Cohen, Aaron
   Colistro, Valentina
   Colquhoun, Samantha M.
   Contreras, Alejandra G.
   Cooper, Leslie T.
   Cooper, Cyrus
   Cooperrider, Kimberly
   Coresh, Josef
   Cortinovis, Monica
   Criqui, Michael H.
   Crump, John A.
   Cuevas-Nasu, Lucia
   Dandona, Rakhi
   Dandona, Lalit
   Dansereau, Emily
   Dantes, Hector G.
   Dargan, Paul I.
   Davey, Gail
   Davitoiu, Dragos V.
   Dayama, Anand
   De la Cruz-Gongora, Vanessa
   de la Vega, Shelley F.
   De Leo, Diego
   del Pozo-Cruz, Borja
   Dellavalle, Robert P.
   Deribe, Kebede
   Derrett, Sarah
   Des Jarlais, Don C.
   Dessalegn, Muluken
   de Veber, Gabrielle A.
   Dharmaratne, Samath D.
   Diaz-Torne, Cesar
   Ding, Eric L.
   Dokova, Klara
   Dorsey, E. R.
   Driscoll, Tim R.
   Duber, Herbert
   Durrani, Adnan M.
   Edmond, Karen M.
   Ellenbogen, Richard G.
   Endres, Matthias
   Ermakov, Sergey P.
   Eshrati, Babak
   Esteghamati, Alireza
   Estep, Kara
   Fahimi, Saman
   Farzadfar, Farshad
   Fay, Derek F. J.
   Felson, David T.
   Fereshtehnejad, Seyed-Mohammad
   Fernandes, Jefferson G.
   Ferri, Cluesa P.
   Flaxman, Abraham
   Foigt, Nataliya
   Foreman, Kyle J.
   Fowkes, F. Gerry R.
   Franklin, Richard C.
   Furst, Thomas
   Futran, Neal D.
   Gabbe, Belinda J.
   Gankpe, Fortune G.
   Garcia-Guerra, Francisco A.
   Geleijnse, Johanna M.
   Gessner, Bradford D.
   Gibney, Katherine B.
   Gillum, Richard F.
   Ginawi, Ibrahim A.
   Giroud, Maurice
   Giussani, Giorgia
   Goenka, Shifalika
   Goginashvili, Ketevan
   Gona, Philimon
   de Cosio, Teresita Gonzalez
   Gosselin, Richard A.
   Gotay, Carolyn C.
   Goto, Atsushi
   Gouda, Hebe N.
   Guerrant, Richard L.
   Gugnani, Harish C.
   Gunnell, David
   Gupta, Rajeev
   Gupta, Rahul
   Gutierrez, Reyna A.
   Hafezi-Nejad, Nima
   Hagan, Holly
   Halasa, Yara
   Hamadeh, Randah R.
   Hamavid, Hannah
   Hammami, Mouhanad
   Hankey, Graeme J.
   Hao, Yuantao
   Harb, Hilda L.
   Haro, Josep Maria
   Havmoeller, Rasmus
   Hay, Roderick J.
   Hay, Simon
   Hedayati, Mohammad T.
   Pi, Ileana B. Heredia
   Heydarpour, Pouria
   Hijar, Martha
   Hoek, Hans W.
   Hoffman, Howard J.
   Hornberger, John C.
   Hosgood, H. Dean
   Hossain, Mazeda
   Hotez, Peter J.
   Hoy, Damian G.
   Hsairi, Mohamed
   Hu, Howard
   Hu, Guoqing
   Huang, John J.
   Huang, Cheng
   Huiart, Laetitia
   Husseini, Abdullatif
   Iannarone, Marissa
   Iburg, Kim M.
   Innos, Kaire
   Inoue, Manami
   Jacobsen, Kathryn H.
   Jassal, Simerjot K.
   Jeemon, Panniyammakal
   Jensen, Paul N.
   Jha, Vivekanand
   Jiang, Guohong
   Jiang, Ying
   Jonas, Jost B.
   Joseph, Jonathan
   Juel, Knud
   Kan, Haidong
   Karch, Andre
   Karimkhani, Chante
   Karthikeyan, Ganesan
   Katz, Ronit
   Kaul, Anil
   Kawakami, Norito
   Kazi, Dhruv S.
   Kemp, Andrew H.
   Kengne, Andre P.
   Khader, Yousef S.
   Khalifa, Shams Eldin A. H.
   Khan, Ejaz A.
   Khan, Gulfaraz
   Khang, Young-Ho
   Khonelidze, Irma
   Kieling, Christian
   Kim, Daniel
   Kim, Sungroul
   Kimokoti, Ruth W.
   Kinfu, Yohannes
   Kinge, Jonas M.
   Kissela, Brett M.
   Kivipelto, Miia
   Knibbs, Luke
   Knudsen, Ann Kristin
   Kokubo, Yoshihiro
   Kosen, Soewarta
   Kramer, Alexander
   Kravchenko, Michael
   Krishnamurthi, Rita V.
   Krishnaswami, Sanjay
   Defo, Barthelemy Kuate
   Bicer, Burcu Kucuk
   Kuipers, Ernst J.
   Kulkarni, Veena S.
   Kumar, Kaushalendra
   Kumar, G. Anil
   Kwan, Gene F.
   Lai, Taavi
   Lalloo, Ratilal
   Lam, Hilton
   Lan, Qing
   Lansingh, Van C.
   Larson, Heidi
   Larsson, Anders
   Lawrynowicz, Alicia E. B.
   Leasher, Janet L.
   Lee, Jong-Tae
   Leigh, James
   Leung, Ricky
   Levi, Miriam
   Li, Bin
   Li, Yichong
   Li, Yongmei
   Liang, Juan
   Lim, Stephen
   Lin, Hsien-Ho
   Lind, Margaret
   Lindsay, M. Patrice
   Lipshultz, Steven E.
   Liu, Shiwei
   Lloyd, Belinda K.
   Ohno, Summer Lockett
   Logroscino, Giancarlo
   Looker, Katharine J.
   Lopez, Alan D.
   Lopez-Olmedo, Nancy
   Lortet-Tieulent, Joannie
   Lotufo, Paulo A.
   Low, Nicola
   Lucas, Robyn M.
   Lunevicius, Raimundas
   Lyons, Ronan A.
   Ma, Jixiang
   Ma, Stefan
   Mackay, Mark T.
   Majdan, Marek
   Malekzadeh, Reza
   Mapoma, Christopher C.
   Marcenes, Wagner
   March, Lyn M.
   Margono, Chris
   Marks, Guy B.
   Marzan, Melvin B.
   Masci, Joseph R.
   Mason-Jones, Amanda J.
   Matzopoulos, Richard G.
   Mayosi, Bongani M.
   Mazorodze, Tasara T.
   McGill, Neil W.
   McGrath, John J.
   McKee, Martin
   McLain, Abby
   McMahon, Brian J.
   Meaney, Peter A.
   Mehndiratta, Man Mohan
   Mejia-Rodriguez, Fabiola
   Mekonnen, Wubegzier
   Melaku, Yohannes A.
   Meltzer, Michele
   Memish, Ziad A.
   Mensah, George
   Meretoja, Atte
   Mhimbira, Francis A.
   Micha, Renata
   Miller, Ted R.
   Mills, Edward J.
   Mitchell, Philip B.
   Mock, Charles N.
   Moffitt, Terrie E.
   Ibrahim, Norlinah Mohamed
   Mohammad, Karzan A.
   Mokdad, Ali H.
   Mola, Glen L.
   Monasta, Lorenzo
   Montico, Marcella
   Montine, Thomas J.
   Moore, Ami R.
   Moran, Andrew E.
   Morawska, Lidia
   Mori, Rintaro
   Moschandreas, Joanna
   Moturi, Wilkister N.
   Moyer, Madeline
   Mozaffarian, Dariush
   Mueller, Ulrich O.
   Mukaigawara, Mitsuru
   Murdoch, Michele E.
   Murray, Joseph
   Murthy, Kinnari S.
   Naghavi, Paria
   Nahas, Ziad
   Naheed, Aliya
   Naidoo, Kovin S.
   Naldi, Luigi
   Nand, Devina
   Nangia, Vinay
   Narayan, K. M. Venkat
   Nash, Denis
   Nejjari, Chakib
   Neupane, Sudan P.
   Newman, Lori M.
   Newton, Charles R.
   Ng, Marie
   Ngalesoni, Frida N.
   Nhung, Nguyen T.
   Nisar, Muhammad I.
   Nolte, Sandra
   Norheim, Ole F.
   Norman, Rosana E.
   Norrving, Bo
   Nyakarahuka, Luke
   Oh, In Hwan
   Ohkubo, Takayoshi
   Omer, Saad B.
   Opio, John Nelson
   Ortiz, Alberto
   Pandian, Jeyaraj D.
   Panelo, Carlo Irwin A.
   Papachristou, Christina
   Park, Eun-Kee
   Parry, Charles D.
   Caicedo, Angel J. Paternina
   Patten, Scott B.
   Paul, Vinod K.
   Pavlin, Boris I.
   Pearce, Neil
   Pedraza, Lilia S.
   Pellegrini, Carlos A.
   Pereira, David M.
   Perez-Ruiz, Fernando P.
   Perico, Norberto
   Pervaiz, Aslam
   Pesudovs, Konrad
   Peterson, Carrie B.
   Petzold, Max
   Phillips, Michael R.
   Phillips, David
   Phillips, Bryan
   Piel, Frederic B.
   Plass, Dietrich
   Poenaru, Dan
   Polanczyk, Guilherme V.
   Polinder, Suzanne
   Pope, C. A., III
   Popova, Svetlana
   Poulton, Richie G.
   Pourmalek, Farshad
   Prabhakaran, Dorairaj
   Prasad, Noela M.
   Qato, Dima
   Quistberg, D. A.
   Rafay, Anwar
   Rahimi, Kazem
   Rahimi-Movaghar, Vafa
   Rahman, Sajjad Ur
   Raju, Murugesan
   Rakovac, Ivo
   Rana, Saleem M.
   Razavi, Homie
   Refaat, Amany
   Rehm, Jurgen
   Remuzzi, Giuseppe
   Resnikoff, Serge
   Ribeiro, Antonio L.
   Riccio, Patricia M.
   Richardson, Lee
   Richardus, Jan Hendrik
   Riederer, Anne M.
   Robinson, Margot
   Roca, Anna
   Rodriguez, Alina
   Rojas-Rueda, David
   Ronfani, Luca
   Rothenbacher, Dietrich
   Roy, Nobhojit
   Ruhago, George M.
   Sabin, Nsanzimana
   Sacco, Ralph L.
   Ksoreide, Kjetil
   Saha, Sukanta
   Sahathevan, Ramesh
   Sahraian, Mohammad Ali
   Sampson, Uchechukwu
   Sanabria, Juan R.
   Sanchez-Riera, Lidia
   Santos, Itamar S.
   Satpathy, Maheswar
   Saunders, James E.
   Sawhney, Monika
   Saylan, Mete I.
   Scarborough, Peter
   Schoettker, Ben
   Schneider, Ione J. C.
   Schwebel, David C.
   Scott, James G.
   Seedat, Soraya
   Sepanlou, Sadaf G.
   Serdar, Berrin
   Servan-Mori, Edson E.
   Shackelford, Katya
   Shaheen, Amira
   Shahraz, Saeid
   Levy, Teresa Shamah
   Shangguan, Siyi
   She, Jun
   Sheikhbahaei, Sara
   Shepard, Donald S.
   Shi, Peilin
   Shibuya, Kenji
   Shinohara, Yukito
   Shiri, Rahman
   Shishani, Kawkab
   Shiue, Ivy
   Shrime, Mark G.
   Sigfusdottir, Inga D.
   Silberberg, Donald H.
   Simard, Edgar P.
   Sindi, Shireen
   Singh, Jasvinder A.
   Singh, Lavanya
   Skirbekk, Vegard
   Sliwa, Karen
   Soljak, Michael
   Soneji, Samir
   Soshnikov, Sergey S.
   Speyer, Peter
   Sposato, Luciano A.
   Sreeramareddy, Chandrashekhar T.
   Stoeckl, Heidi
   Stathopoulou, Vasiliki Kalliopi
   Steckling, Nadine
   Stein, Murray B.
   Stein, Dan J.
   Steiner, Timothy J.
   Stewart, Andrea
   Stork, Eden
   Stovner, Lars J.
   Stroumpoulis, Konstantinos
   Sturua, Lela
   Sunguya, Bruno F.
   Swaroop, Mamta
   Sykes, Bryan L.
   Tabb, Karen M.
   Takahashi, Ken
   Tan, Feng
   Tandon, Nikhil
   Tanne, David
   Tanner, Marcel
   Tavakkoli, Mohammad
   Taylor, Hugh R.
   Ao, Braden J. Te
   Temesgen, Awoke Misganaw
   Ten Have, Margreet
   Tenkorang, Eric Yeboah
   Terkawi, Abdullah Sulieman
   Theadom, Alice M.
   Thomas, Elissa
   Thorne-Lyman, Andrew L.
   Thrift, Amanda G.
   Tleyjeh, Imad M.
   Tonelli, Marcello
   Topouzis, Fotis
   Towbin, Jeffrey A.
   Toyoshima, Hideaki
   Traebert, Jefferson
   Tran, Bach X.
   Trasande, Leonardo
   Trillini, Matias
   Truelsen, Thomas
   Trujillo, Ulises
   Tsilimbaris, Miltiadis
   Tuzcu, Emin M.
   Ukwaja, Kingsley N.
   Undurraga, Eduardo A.
   Uzun, Selen B.
   van Brakel, Wim H.
   de Vijver, Steven van
   Van Dingenen, Rita
   van Gool, Coen H.
   Varakin, Yuri Y.
   Vasankari, Tommi J.
   Vavilala, Monica S.
   Veerman, Lennert J.
   Velasquez-Melendez, Gustavo
   Venketasubramanian, Narayanaswamy
   Vijayakumar, Lakshmi
   Villalpando, Salvador
   Violante, Francesco S.
   Vlassov, Vasiliy V.
   Waller, Stephen
   Wallin, Mitchell T.
   Wan, Xia
   Wang, Linhong
   Wang, JianLi
   Wang, Yanping
   Warouw, Tati S.
   Weichenthal, Scott
   Weiderpass, Elisabete
   Weintraub, Robert G.
   Werdecker, Andrea
   Wessells, K. Ryan R.
   Westerman, Ronny
   Wilkinson, James D.
   Williams, Hywel C.
   Williams, Thomas N.
   Woldeyohannes, Solomon M.
   Wolfe, Charles D. A.
   Wong, John Q.
   Wong, Haidong
   Woolf, Anthony D.
   Wright, Jonathan L.
   Wurtz, Brittany
   Xu, Gelin
   Yang, Gonghuan
   Yano, Yuichiro
   Yenesew, Muluken A.
   Yentur, Gokalp K.
   Yip, Paul
   Yonemoto, Naohiro
   Yoon, Seok-Jun
   Younis, Mustafa
   Yu, Chuanhua
   Kim, Kim Yun
   Zaki, Maysaa El Sayed
   Zhang, Yong
   Zhao, Zheng
   Zhao, Yong
   Zhu, Jun
   Zonies, David
   Zunt, Joseph R.
   Salomon, Joshua A.
   Murray, Christopher J. L.
CA Global Burden Dis Study
TI Global, regional, and national incidence, prevalence, and years lived
   with disability for 301 acute and chronic diseases and injuries in 188
   countries, 1990-2013: a systematic analysis for the Global Burden of
   Disease Study 2013
SO LANCET
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ALCOHOL DEPENDENCE; CUTANEOUS
   LEISHMANIASIS; MENTAL-DISORDERS; CONDUCT DISORDER; HEALTH OUTCOMES;
   IRON-DEFICIENCY; OTITIS-MEDIA; WEIGHTS; EPIDEMIOLOGY
AB Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
   Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries.
   Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013.
   Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
C1 [Vos, Theo; Barber, Ryan M.; Bell, Brad; Bertozzi-Villa, Amelia; Biryukov, Stan; Bolliger, Ian; Dicker, Daniel; Fitzmaurice, Christina; Fleming, Thomas; Graetz, Nicholas; Haagsma, Juanita; Hansen, Gillian M.; Hanson, Sarah Wulf; Heuton, Kyle R.; Higashi, Hideki; Kyu, Hmwe; Laurie, Evan; Lofgren, Katherine; Lozano, Rafael; MacIntyre, Michael F.; Moradi-Lakeh, Maziar; Naghavi, Mohsen; Nguyen, Grant; Odell, Shaun; Ortblad, Katrina; Roberts, David Allen; Roth, Gregory A.; Sandar, Logan; Serina, Peter T.; Stanaway, Jeffrey D.; Steiner, Caitlyn; Thomas, Bernadette; Vollset, Stein Emil; Wolock, Timothy M.; Achoki, Tom; Apfel, Henry; Atkinson, Charles; Bienhoff, Kelly; Blore, Jed D.; Brown, Jonathan; Coggeshall, Megan; Cohen, Aaron; Cooperrider, Kimberly; Dandona, Lalit; Dansereau, Emily; Duber, Herbert; Estep, Kara; Flaxman, Abraham; Foreman, Kyle J.; Hamavid, Hannah; Iannarone, Marissa; Joseph, Jonathan; Lim, Stephen; Lind, Margaret; Ohno, Summer Lockett; Lopez, Alan D.; Margono, Chris; McLain, Abby; Mokdad, Ali H.; Moyer, Madeline; Naghavi, Paria; Phillips, David; Phillips, Bryan; Richardson, Lee; Robinson, Margot; Shackelford, Katya; Singh, Lavanya; Speyer, Peter; Stewart, Andrea; Stork, Eden; Thomas, Elissa; Wong, Haidong; Wurtz, Brittany; Murray, Christopher J. L.] Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.
   [Ellenbogen, Richard G.] Harborview Hosp, Seattle, WA USA.
   [Ellenbogen, Richard G.] Childrens Hosp, Dept Med, Seattle, WA USA.
   [Kassebaum, Nicholas] Childrens Hosp, Seattle, WA USA.
   [Katz, Ronit] Kidney Res Inst, Seattle, WA USA.
   [Alfonso-Cristancho, Rafael; Anderson, Benjamin O.; Futran, Neal D.; Jensen, Paul N.; Mock, Charles N.; Montine, Thomas J.; Pellegrini, Carlos A.; Quistberg, D. A.; Riederer, Anne M.; Vavilala, Monica S.; Zunt, Joseph R.] Univ Washington, Sch Med, Seattle, WA USA.
   [Hoy, Damian G.] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia.
   [Scott, James G.] Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia.
   [Charlson, Fiona; Erskine, Holly; Ferrari, Alize J.; Whiteford, Harvey; Gouda, Hebe N.; Knibbs, Luke; McGrath, John J.; Norman, Rosana E.; Veerman, Lennert J.] Publ Hlth England, London, England.
   [Boufous, Soufiane] Univ New S Wales, Transport & Rd Safety TARS Res, Sydney, NSW, Australia.
   [Degenhardt, Louisa; Mitchell, Philip B.; Satpathy, Maheswar] Univ New S Wales, Sydney, NSW, Australia.
   [Duan, Leilei; Liang, Xiofeng; Ye, Pengpeng; Zhou, Maigeng; Li, Yichong; Liu, Shiwei; Ma, Jixiang; Wang, Linhong] Chinese Ctr Dis Control, Natl Centers Chron & Noncommunible Dis Control &, Beijing, Peoples R China.
   [Feigin, Valery L.; Balalla, Shivanthi] Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand.
   [Krishnamurthi, Rita V.; Ao, Braden J. Te; Theadom, Alice M.] Auckland Univ Technol, Auckland, New Zealand.
   [Guinovart, Caterina] PATH, Seattle, WA USA.
   [Lozano, Rafael; Avila, Marco A.; Aburto, Tania C.; Barquera, Simon; Nonato, Ismael R. Campos; Campuzano, Julio C.; Contreras, Alejandra G.; Cuevas-Nasu, Lucia; Dantes, Hector G.; De la Cruz-Gongora, Vanessa; Garcia-Guerra, Francisco A.; de Cosio, Teresita Gonzalez; Pi, Ileana B. Heredia; Lopez-Olmedo, Nancy; Mejia-Rodriguez, Fabiola; Pedraza, Lilia S.; Servan-Mori, Edson E.; Levy, Teresa Shamah; Villalpando, Salvador] Natl Inst Publ Hlth, Mexico City, DF, Mexico.
   [Aasvang, Gunn Marit; Kinge, Jonas M.; Knudsen, Ann Kristin; Skirbekk, Vegard] Norwegian Inst Publ Hlth, Oslo, Norway.
   [Abbafati, Cristiana] Univ Roma La Sapienza, I-00185 Rome, Italy.
   [Ozgoren, Ayse Abbasoglu] Hacettepe Univ, Inst Populat Studies, Ankara, Turkey.
   [Abd-Allah, Foad] Cairo Univ, Fac Med, Cairo, Egypt.
   [Aziz, Muna I. Abdel] Inst Publ Hlth, Khartoum, Sudan.
   [Abera, Semaw F.; Melaku, Yohannes A.] Mekelle Univ, Coll Hlth Sci, Sch Publ Hlth, Mekelle, Ethiopia.
   [Aboyans, Victor] Dupuytren Univ Hosp, Limoges, France.
   [Abraham, Biju] Oslo & Akershus Univ Coll Appl Sci HiOA, Oslo, Norway.
   [Abraham, Jerry P.] Univ Texas Sch Med, San Antonio, TX USA.
   [Benzian, Habib] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Abubakar, Ibrahim] UCL, London, England.
   [Abu-Raddad, Laith J.] Weill Cornell Med Coll Qatar, Doha, Qatar.
   [Abu-Rmeileh, Niveen M. E.] Birzeit Univ, Inst Community & Publ Hlth, Birzeit, Israel.
   [Chiang, Peggy P.] Univ Melbourne, Gen Practice & Primary Hlth Care Acad Ctr, Melbourne, Vic, Australia.
   [Colquhoun, Samantha M.] Univ Melbourne, Ctr Int Child Hlth, Melbourne, Vic, Australia.
   [Taylor, Hugh R.] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
   [Ackerman, Ilana N.; Ademi, Zanfina; Bohensky, Megan A.; Brooks, Peter M.; Lopez, Alan D.; Meretoja, Atte; Weintraub, Robert G.] Univ Melbourne, Melbourne, Vic, Australia.
   [Adelekan, Ademola] Publ Hlth Promot Alliance, Osogbo, Nigeria.
   [Adou, Arsene K.] Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire.
   [Adsuar, Josef C.] Univ Extremadura, Caceres, Spain.
   [Agardh, Emilie E.] Inst Publ Hlth Sci, Stockholm, Sweden.
   [Al Khabouri, Mazin J.; Alasfoor, Deena] Minist Hlth, Muskat, Oman.
   [Alam, Sayed Saidul; Naheed, Aliya] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh.
   [Alegretti, Miguel A.] Univ Republica, Fac Med, Dept Med Prevent & Social, Montevideo, Uruguay.
   [Aleman, Alicia V.] Univ Republica, Sch Med, Montevideo, Uruguay.
   [Colistro, Valentina] Univ Republica, Dept Med, Montevideo, Uruguay.
   [Alemu, Zewdie A.] Debre Markos Univ, Debre Markos, Amhara, Ethiopia.
   [Alhabib, Samia] Natl Guard Hlth Affairs, Riyadh, Saudi Arabia.
   [Ali, Raghib; Bennett, Derrick A.; Briggs, Adam D. M.; Hay, Simon; Piel, Frederic B.; Rahimi, Kazem; Scarborough, Peter] Univ Oxford, Oxford, England.
   [Alla, Francois] Univ Lorraine, Sch Publ Hlth, Nancy, France.
   [Allebeck, Peter] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
   [Fereshtehnejad, Seyed-Mohammad] Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Stockholm, Sweden.
   [Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Kivipelto, Miia] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden.
   [Havmoeller, Rasmus; Sindi, Shireen] Karolinska Inst, Stockholm, Sweden.
   [Allen, Peter J.] Minist Hlth, Belmopan, Belize.
   [AlMazroa, Mohammad AbdulAziz] Saudi Minist Hlth, Riyadh, Saudi Arabia.
   [Alsharif, Ubai; Endres, Matthias; Nolte, Sandra; Papachristou, Christina] Charite, D-13353 Berlin, Germany.
   [Alvarez, Elena] Govt Spain, Madrid, Spain.
   [Alvis-Guzman, Nelson; Caicedo, Angel J. Paternina] Univ Cartagena, Cartagena De Indias, Colombia.
   [Sreeramareddy, Chandrashekhar T.] Univ Groningen, Univ Med Ctr Groningen, Coll Med & Hlth Sci, Dept Epidemiol, Groningen, Netherlands.
   [Yenesew, Muluken A.] Bahir Dar Univ, Bahir Dar, Ethiopia.
   [Ameli, Omid; Felson, David T.] Boston Univ, Boston, MA 02215 USA.
   [Amini, Heresh] Kurdistan Univ Med Sci, Kurdistan Environm Hlth Res Ctr, Sanandaj, Kurdistan, Iran.
   [Amini, Heresh; Tanner, Marcel] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.
   [Amini, Heresh] Univ Basel, Basel, Switzerland.
   [Ammar, Walid; Harb, Hilda L.] Minist Publ Hlth, Beirut, Lebanon.
   [Anderson, H. Ross; Marcenes, Wagner] Univ London, London, England.
   [Antonio, Carl Abelardo T.; Panelo, Carlo Irwin A.] Univ Philippines, Coll Publ Hlth, Manila, Philippines.
   [Anwari, Palwasha] United Nations Populat Fund, Kabul, Afghanistan.
   [Arnlov, Johan; Larsson, Anders] Uppsala Univ, Uppsala, Norway.
   [Arsenijevic, Valentain S. Arsic] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade, Serbia.
   [Artaman, Al] Evidera Inc, Lexington, KY USA.
   [Asghar, Rana J.] South Asian Publ Hlth Forum, Islamabad, Pakistan.
   [Assadi, Reza] Mashhad Univ Med Sci, Mashhad, Iran.
   [Atkins, Lydia S.] Minist Hlth, Wellness Human Serv & Gender Relat, St Lucia, Qld, Australia.
   [Badawi, Alaa] Publ Hlth Agcy Canada, Toronto, ON, Canada.
   [Bahit, Maria C.] INECO Neurociencias, Rosario, Santa Fe, Argentina.
   [Bakfalouni, Talal] Minist Hlth, Damascus, Syria.
   [Balakrishnan, Kalpana] Sri Ramachandra Univ, Madras, Tamil Nadu, India.
   [Banerjee, Amitava] Univ Birmingham, Birmingham, W Midlands, England.
   [Barker-Collo, Suzanne L.] Univ Auckland, Sch Psychol, Auckland 1, New Zealand.
   [del Pozo-Cruz, Borja] Univ Auckland, Auckland 1, New Zealand.
   [Barregard, Lars] Univ Gothenburg, Dept Occupat & Environm Hlth, Gothenburg, Sweden.
   [Petzold, Max] Univ Gothenburg, Hlth Metr Sahlgrenska Acad, Gothenburg, Sweden.
   [Barrero, Lope H.] Pontificia Univ Javeriana, Dept Ind Engn, Bogota, Colombia.
   [Basu, Arindam] Univ Canterbury, Sch Hlth Sci, Christchurch 1, New Zealand.
   [Basu, Sanjay] Stanford Univ, Stanford, CA 94305 USA.
   [Beardsley, Justin] Univ Oxford, Ho Hi Minh City, Vietnam.
   [Bedi, Neeraj] Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia.
   [Beghi, Ettore; Remuzzi, Giuseppe] Mario Negri, Milan, Italy.
   [Ronfani, Luca] Burlo Garofolo, Trieste, Italy.
   IRCCS Ist Ric Farmacol, Milan, Italy.
   [Bekele, Tolesa; Cortinovis, Monica; Giussani, Giorgia; Monasta, Lorenzo; Montico, Marcella; Perico, Norberto; Trillini, Matias] Madawalabu Univ, Bale Robe, Ethiopia.
   [Bell, Brad; Huang, John J.] Yale Univ, New Haven, CT USA.
   [Benjet, Corina; Borges, Guilherme; Gutierrez, Reyna A.] Natl Inst Psychiat Ramon Fuente Muniz, Mexico City, DF, Mexico.
   [Bensenor, Isabela M.] Univ Sao Paulo, Univ Hosp, Sao Paulo, Brazil.
   [Kemp, Andrew H.; Lotufo, Paulo A.; Polanczyk, Guilherme V.; Santos, Itamar S.] Univ Sao Paulo, Sao Paulo, Brazil.
   [Bernabe, Eduardo; Wolfe, Charles D. A.] Kings Coll London, London WC2R 2LS, England.
   [Beyene, Tariku J.; Deribe, Kebede] Univ Addis Ababa, Addis Ababa, Ethiopia.
   [Bhalla, Ashish] Wellington Hosp, Wellington, New Zealand.
   [Bhalla, Ashish] Postgrad Inst Med Educ & Res, Chandigarh, UT, India.
   [Bhutta, Zulfi Qar] Aga Khan Univ, Med Ctr, Karachi, Pakistan.
   [Nisar, Muhammad I.] Aga Khan Univ, Karachi, Pakistan.
   [Bikbov, Boris] I Evdokimov Moscow State Univ Med & Dent, Moscow, Russia.
   [Bin Abdulhak, Aref] Univ Missouri, Kansas City, KS USA.
   [Driscoll, Tim R.] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia.
   [Marks, Guy B.] Univ Sydney, Woolcock Inst Med Res, Sydney, NSW 2006, Australia.
   [Uzun, Selen B.] Minist Hlth, Ankara, Turkey.
   [Basara, Berrak Bora] Gen Directorate Hlth Res, Ankara, Turkey.
   [Bornstein, Natan M.] Tel Aviv Saurasky Med Ctr, Tel Aviv, Israel.
   [Bose, Dipan] World Bank, Washington, DC 20433 USA.
   [Bourne, Rupert R.] Anglia Ruskin Univ, Vis & Eye Res Unit, Cambridge, England.
   [Boyers, Lindsay N.] Georgetown Univ, Sch Med, Washington, DC USA.
   [Wallin, Mitchell T.] Georgetown Univ, Dept Neurol, Washington, DC USA.
   [Brainin, Michael] Danube Univ Krems, Krems An Der Donau, Austria.
   [Brauer, Michael; Gotay, Carolyn C.; Pourmalek, Farshad] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
   [Brayne, Carol E. G.] Cambridge Inst Publ Hlth, Cambridge, England.
   [Brazinova, Alexandra; Majdan, Marek] Trnava Univ, Fac Hlth Sci & Social Work, Trnava, Slovakia.
   [Breitborde, Nicholas J. K.] Univ Arizona, Tucson, AZ USA.
   [Schoettker, Ben] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
   [Brenner, Hermann] German Canc Res Ctr, Heidelberg, Germany.
   [Brugha, Traolach S.] Univ Leicester, Leicester, Leics, England.
   [Buchbinder, Rachelle] Monash Univ, Melbourne, Vic 3004, Australia.
   [Buchbinder, Rachelle] Cabrini Inst, Melbourne, Vic, Australia.
   [Buckle, Geoffrey C.; Gona, Philimon] Univ Massachusetts, Sch Med, Worcester, MA USA.
   [Bukhman, Gene] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
   [Ding, Eric L.; Fahimi, Saman; Shangguan, Siyi] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA.
   [Shrime, Mark G.; Salomon, Joshua A.] Harvard Univ, Cambridge, MA 02138 USA.
   [Bulloch, Andrew G.; Patten, Scott B.; Wang, JianLi] Univ Calgary, Calgary, AB, Canada.
   [Burch, Michael; Burnett, Richard] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Cabral, Norberto L.] Univ Joinville, Joinville, Brazil.
   [Carapetis, Jonathan R.] Telethon Inst Child Hlth Res, Perth, Australia.
   [Cardenas, Rosario] Univ Autonoma Metropolitana, Mexico City, DF, Mexico.
   [Carpenter, David O.] SUNY Albany, Albany, NY 12222 USA.
   [Caso, Valeria] Univ Perugia, Stroke Unit, I-06100 Perugia, Italy.
   [Castaneda-Orjuela, Carlos A.] Inst Nacl Salud, Colombian Natl Hlth Observ, Bogota, Colombia.
   [Catala-Lopez, Ferran] Minist Hlth, Spanish Med & Healthcare Prod Agcy AEMPS, Div Pharmacoepidemiol & Pharmacovigilance, Madrid, Spain.
   [Chadha, Vineet K.] Natl TB Inst, Bangalore, Karnataka, India.
   [Lin, Hsien-Ho] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.
   [Chang, Jung-Chen] Natl Taiwan Univ, Taipei 10764, Taiwan.
   [Chen, Wanqing] Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China.
   [Chen, Honglei] NIEHS, Div Intramural Res, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA.
   [Jiang, Ying; Takahashi, Ken] Univ Occupat & Environm Hlth, Dept Hlth Dev, Inst Ind Ecol Sci, Kitakyushu, Fukuoka 807, Japan.
   [Chimed-Ochir, Odgerel; Jiang, Ying; Takahashi, Ken] Univ Occupat & Environm Hlth, Dept Environm, Dept Environm Epidemiol, Kitakyushu, Fukuoka 807, Japan.
   [Chowdhury, Rajiv; Murray, Joseph] Univ Cambridge, Cambridge, England.
   [Christensen, Hanne] Bispebjerg Hosp, Copenhagen, Denmark.
   [Christophi, Costas A.] Cyprus Univ Technol, Limassol, Cyprus.
   [Chugh, Sumeet S.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   [Cirillo, Massimo] Univ Salerno, I-84100 Salerno, Italy.
   [Cohen, Aaron] Hlth Eff ects Inst, Boston, MA USA.
   [Cooper, Leslie T.; Tleyjeh, Imad M.] Mayo Clin, Rochester, MN USA.
   [Cooper, Cyrus] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Coresh, Josef; Tran, Bach X.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Jassal, Simerjot K.] VA San Diego, San Diego, CA USA.
   [Stein, Murray B.] Univ Calif San Diego, San Diego, CA 92103 USA.
   [Crump, John A.] Univ Otago, Dunedin Sch Med, Ctr Int Hlth, Dunedin, New Zealand.
   [Poulton, Richie G.] Univ Otago, Dunedin, New Zealand.
   [Goenka, Shifalika] Indian Inst Publ Hlth, Delhi, India.
   [Dandona, Rakhi; Kumar, G. Anil; Murthy, Kinnari S.] Publ Hlth Fdn India, Delhi, India.
   [Dargan, Paul I.] Guys & St Thomas NHS Fdn Trust, London, England.
   [Davey, Gail] Brighton & Sussex Med Sch, Brighton, E Sussex, England.
   [Davitoiu, Dragos V.] Univ Med & Pharm Bucharest, Bucharest, Romania.
   [Dayama, Anand] Jacobi Med Ctr, Dept Surg, New York, NY USA.
   [de la Vega, Shelley F.] Natl Inst Hlth, Inst Aging, Manila, Philippines.
   [Lam, Hilton] Natl Inst Hlth, Inst Hlth Policy & Dev Studies, Manila, Philippines.
   [De Leo, Diego] Griffith Univ, Nathan, Qld 4111, Australia.
   [Dellavalle, Robert P.] Eastern Colorado Healthcare Syst, Dept Vet Aff, Denver, CO USA.
   [Derrett, Sarah] Massey Univ, Palmerston North, New Zealand.
   [Des Jarlais, Don C.] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA.
   [Dessalegn, Muluken] Africa Med & Res Fdn Ethiopia, Addis Ababa, Ethiopia.
   [de Veber, Gabrielle A.] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Dharmaratne, Samath D.] Univ Peradeniya, Peradeniya, Sri Lanka.
   [Diaz-Torne, Cesar] Hosp Santa Creu & Sant Pau, Barcelona, Spain.
   [Dokova, Klara] Med Univ Varna, Fac Publ Hlth, Dept Social Med, Varna, Bulgaria.
   [Dorsey, E. R.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
   [Hoffman, Howard J.] NIDCD, Bethesda, MD USA.
   [Durrani, Adnan M.] NIH, Bethesda, MD 20892 USA.
   [Hankey, Graeme J.] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia.
   [Edmond, Karen M.] Univ Western Australia, Crawley, WA, Australia.
   [Ermakov, Sergey P.] Russian Acad Sci, Inst Social & Econ Studies Populat, Chernogolovka 142432, Russia.
   [Eshrati, Babak] Arak Univ Med Sci & Hlth Aff airs, Arak, Markazi, Iran.
   [Esteghamati, Alireza; Farzadfar, Farshad; Hafezi-Nejad, Nima; Sheikhbahaei, Sara] Endocrine & Metab Res Inst, Noncommun Dis Res Ctr, Tehran, Iran.
   [Malekzadeh, Reza; Sepanlou, Sadaf G.] Digest Dis Res Ctr, Tehran, Iran.
   [Rahimi-Movaghar, Vafa] Sina Trauma & Surg Res Ctr, Tehran, Iran.
   [Sahraian, Mohammad Ali] MS Res Ctr, Tehran, Iran.
   [Heydarpour, Pouria] Univ Tehran Med Sci, Tehran, Iran.
   [Fernandes, Jefferson G.] German Hosp Oswaldo Cruz, Inst Educ & Sci, Sao Paulo, Brazil.
   [Ferri, Cluesa P.] Univ Fed Sao Paulo, Sao Paulo, Brazil.
   [Foigt, Nataliya] Ukraine Acad Med Sci, Inst Gerontol, UA-252655 Kiev, Ukraine.
   [Fowkes, F. Gerry R.] Univ Edinburgh, Edinburgh, Midlothian, Scotland.
   [Franklin, Richard C.] James Cook Univ, Townsville, Qld 4811, Australia.
   [Furst, Thomas] Univ London Imperial Coll Sci Technol & Med, Ctr Hlth Policy, London, England.
   [Furst, Thomas] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England.
   [Rodriguez, Alina; Soljak, Michael] Univ London Imperial Coll Sci Technol & Med, London, England.
   [Lloyd, Belinda K.] Monash Univ, Eastern Hlth Clin Sch, Malvern East, Vic, Australia.
   [Gabbe, Belinda J.; Gibney, Katherine B.; Thrift, Amanda G.] Monash Univ, Malvern East, Vic, Australia.
   [Gankpe, Fortune G.] Clin Cooperat Parakou, Parakou, Borgou, Benin.
   [Geleijnse, Johanna M.] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.
   [Gessner, Bradford D.] Agence Med Prevent, Paris, France.
   [Gillum, Richard F.] Howard Univ, Washington, DC 20059 USA.
   [Ginawi, Ibrahim A.] Univ Hail, Coll Med, Hail, Saudi Arabia.
   [Giroud, Maurice] Univ Hosp Dijon, Dijon, France.
   [Goginashvili, Ketevan] Minist Labour Hlth & Social Aff airs, Tbilisi, Rep of Georgia.
   [Gosselin, Richard A.; Kazi, Dhruv S.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Goto, Atsushi] Natl Ctr Global Hlth & Med, Dept Diabet Res, Tokyo, Japan.
   [Guerrant, Richard L.] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA.
   [Terkawi, Abdullah Sulieman] Univ Virginia, Dept Anesthesiol, Charlottesville, VA USA.
   [Gugnani, Harish C.] St James Sch Med, Willemstad, Neth Antilles.
   [Gunnell, David; Looker, Katharine J.] Univ Bristol, Bristol, Avon, England.
   [Gupta, Rahul] Fortis Escorts Hosp, Delhi, India.
   [Gupta, Rajeev] Kanawha Charleston Hlth Dept, Charleston, WV USA.
   [Hagan, Holly; Trasande, Leonardo] NYU, Sch Med, New York, NY USA.
   [Halasa, Yara; Shahraz, Saeid; Shepard, Donald S.; Undurraga, Eduardo A.] Brandeis Univ, Waltham, MA USA.
   [Hamadeh, Randah R.] Arabian Gulf Univ, Manama, Bahrain.
   [Hammami, Mouhanad] Wayne Cty Dept Hlth & Human Serv, Wayne, MI USA.
   [Zhao, Yong] Sun Yae Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China.
   [Haro, Josep Maria] Univ Barcelona, CIBERSAM, Parc Sanitari St Joan de Deu, Barcelona, Spain.
   [Hay, Roderick J.] Int Fdn Dermatol, London, England.
   [Hedayati, Mohammad T.] Mazandaran Univ Med Sci, Sari, Mazandaran, Iran.
   [Hijar, Martha] Fdn Entornos AC, Cuernavaca, Morelos, Mexico.
   [Hoek, Hans W.] Parnassia Psychiat Inst, The Hague, Netherlands.
   [Hornberger, John C.] Cedar Associates, Menlo Pk, CA USA.
   [Hosgood, H. Dean] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Hossain, Mazeda; Larson, Heidi; McKee, Martin; Pearce, Neil; Stoeckl, Heidi] London Sch Hyg & Trop Med, London WC1, England.
   [Hotez, Peter J.] Baylor Coll Med, Waco, TX USA.
   [Hsairi, Mohamed] Minist Hlth, Natl Inst Publ Hlth, Tunis, Tunisia.
   [Hoy, Damian G.] Secretariat Pacific Community, Publ Hlth Div, Noumea, New Caledonia.
   [Hu, Guoqing] Cent S Univ, Changsha, Hunan, Peoples R China.
   [Hu, Howard] Univ Toronto, Toronto, ON, Canada.
   [Huiart, Laetitia] George Washington Univ, Washington, DC USA.
   [Huiart, Laetitia] Ctr Hosp Univ La Reunion, Stanford, CA USA.
   [Husseini, Abdullatif] Qatar Univ, Publ Hlth Program, Doha, Qatar.
   [Iburg, Kim M.] Aarhus Univ, Aarhus, Denmark.
   [Innos, Kaire] Natl Inst Hlth Dev, Tallinn, Estonia.
   [Inoue, Manami] Univ Tokyo, Grad Sch Med, Tokyo, Japan.
   [Kawakami, Norito] Univ Tokyo, Sch Publ Hlth, Tokyo, Japan.
   [Jacobsen, Kathryn H.] George Mason Univ, Fairfax, VA 22030 USA.
   [Jeemon, Panniyammakal; Prabhakaran, Dorairaj] Ctr Chron Dis Control, New Delhi, India.
   [Jha, Vivekanand] Postgrad Inst Med Educ & Res, Chandigarh 160012, India.
   [Jiang, Guohong] Tianjin Ctr Dis Control & Prevent, Tianjin, Peoples R China.
   [Jonas, Jost B.] Heidelberg Univ, Dept Ophthalmol, Med Fac Mannheim, Heidelberg, Germany.
   [Juel, Knud] Natl Inst Publ Hlth, Copenhagen, Denmark.
   [She, Jun] Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China.
   [Kan, Haidong] Fudan Univ, Shanghai 200433, Peoples R China.
   [Karch, Andre] Holtz Ctr Infect Res, Braunschweig, Germany.
   [Karch, Andre] German Ctr Infect Res DZIF, Hannover, Germany.
   [Karimkhani, Chante] Columbia Univ, Coll Phys & Surg, New York, NY USA.
   [Moran, Andrew E.] Columbia Univ, New York, NY USA.
   [Karthikeyan, Ganesan; Paul, Vinod K.; Tandon, Nikhil] All India Inst Med Sci, New Delhi, India.
   [Kaul, Anil] Oklahoma State Univ, Stillwater, OK 74078 USA.
   [Kengne, Andre P.] South African Med Res Council, Cape Town, South Africa.
   [Khader, Yousef S.] Jordan Univ Sci & Technol, Irbid, Jordan.
   [Khalifa, Shams Eldin A. H.] Supreme Council Hlth, Doha, Qatar.
   [Khan, Ejaz A.] Hlth Serv Acad, Islamabad, Punjab, Pakistan.
   [Khan, Gulfaraz] UAE Univ, Abu Dhabi, U Arab Emirates.
   [Khang, Young-Ho] Seoul Natl Univ, Coll Med, Inst Hlth Policy & Management, Seoul, South Korea.
   [Khonelidze, Irma; Sturua, Lela] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia.
   [Kieling, Christian] Univ Fed Rio Grande do Sul, Curitiba, Parana, Brazil.
   [Kim, Daniel] Northeastern Univ, Boston, MA 02115 USA.
   [Kim, Sungroul] Soonchunhyang Univ, Asan, South Korea.
   [Kimokoti, Ruth W.] Simmons Coll, Boston, MA 02115 USA.
   [Kinfu, Yohannes] Univ Canberra, Canberra, ACT 2601, Australia.
   [Kissela, Brett M.] Univ Cincinnati, Cincinnati, OH USA.
   [Kokubo, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan.
   [Kosen, Soewarta] MoH Indonesia, NIHRD, Ctr Community Empowerment Hlth Policy & Human, Jakarta, Indonesia.
   [Warouw, Tati S.] MoH Indonesia, NIHRD, Jakarta, Indonesia.
   [Kramer, Alexander] Univ Bielefeld, Sch Publ Hlth, D-33615 Bielefeld, Germany.
   [Plass, Dietrich] Univ Bielefeld, Dept Publ Hlth Med, D-33615 Bielefeld, Germany.
   [Kravchenko, Michael] Res Ctr Neurol, Moscow, Russia.
   [Krishnaswami, Sanjay] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [Defo, Barthelemy Kuate] Univ Montreal, Montreal, PQ, Canada.
   [Bicer, Burcu Kucuk] Hacettepe Univ, Ankara, Turkey.
   [Polinder, Suzanne] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
   [Kuipers, Ernst J.; Richardus, Jan Hendrik] Erasmus MC, Univ Med Ctr, Rotterdam, Netherlands.
   [Kulkarni, Veena S.] Arkansas State Univ, Jonesboro, AR USA.
   [Kumar, Kaushalendra] Int Inst Populat Sci, Mimbai, India.
   [Kwan, Gene F.] Boston Med Ctr, Boston, MA USA.
   [Lai, Taavi] Fourth View Consulting, Tallinn, Estonia.
   [Lalloo, Ratilal] Univ Adelaide, Sch Dent, ARCPOH, Gold Coast, Qld, Australia.
   [Lan, Qing] NCI, Rockville, MD USA.
   [Lansingh, Van C.] IAPB & Vis 2020 LA, Weston, FL USA.
   [Lawrynowicz, Alicia E. B.] Inst Nacl Epidemiol Dr Juan H Jara, Buenos Aires, DF, Argentina.
   [Leasher, Janet L.] Nova SE Univ, Ft Lauderdale, FL 33314 USA.
   [Lee, Jong-Tae; Yoon, Seok-Jun] Korea Univ, Seoul, South Korea.
   [Leung, Ricky] SUNY Albany, Albany, NY 12222 USA.
   [Levi, Miriam] Tuscany Reg Ctr Occupat Injuries & Dis, Florence, Italy.
   [Li, Yichong] Genentech Inc, San Francisco, CA 94080 USA.
   [Zhang, Yong] Jinan Cent Hosp, Dept Gerontol, Jinan, Shandong, Peoples R China.
   [Liang, Juan] Sichuan Univ, West China Univ Hosp 2, Natl Off Maternal & Child Hlth Surveillance, Chengdu 610064, Sichuan, Peoples R China.
   [Lindsay, M. Patrice] Heart & Stroke Fdn Canada, Ottawa, ON, Canada.
   [Lipshultz, Steven E.] Wayne State Univ, Detroit, MI USA.
   [Lloyd, Belinda K.] Eastern Hlth, Turning Point Alcohol & Drug Ctr, Fitzroy, Vic, Australia.
   [Logroscino, Giancarlo] Univ Bari, Bari, Italy.
   [Lortet-Tieulent, Joannie] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Low, Nicola] Univ Bern, CH-3012 Bern, Switzerland.
   [Lucas, Robyn M.] Australian Natl Univ, Canberra, ACT, Australia.
   [Lunevicius, Raimundas] Aintree Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England.
   [Lyons, Ronan A.] Swansea Univ, Swansea, W Glam, Wales.
   [Ma, Stefan; Zhao, Zheng] Minist Hlth Singapore, Singapore, Singapore.
   [Weintraub, Robert G.] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
   [Mackay, Mark T.] Royal Childrens Hosp Melbourne, Melbourne, Vic, Australia.
   [Mapoma, Christopher C.] Univ Zambia, Lusaka, Zambia.
   [Marzan, Melvin B.] Univ East Ramon Magsaysay Med Ctr, Quezon City, Philippines.
   [Masci, Joseph R.] Elmhurst Hosp Ctr, Mt Sinai Serv, Elmhurst, NY USA.
   [Mason-Jones, Amanda J.] Univ York, York YO10 5DD, N Yorkshire, England.
   [Matzopoulos, Richard G.; Parry, Charles D.] MRC, Cape Town, Western Cape, South Africa.
   [Sliwa, Karen] Univ Cape Town, Fac Hlth Sci, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, South Africa.
   [Mayosi, Bongani M.; Stein, Dan J.] Univ Cape Town, ZA-7925 Cape Town, South Africa.
   [Mazorodze, Tasara T.] AIDC EC, Port Elizabeth, Eastern Cape, South Africa.
   [McGill, Neil W.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA.
   [Meaney, Peter A.] Univ Penn, Pereleman Sch Med, Philadelphia, PA 19104 USA.
   [Silberberg, Donald H.] Univ Penn, Philadelphia, PA 19104 USA.
   [Mehndiratta, Man Mohan] Janakpuri Superspecialty Hosp, Delhi, India.
   [Meltzer, Michele] Thomas Jefferson Univ, Philadelphia, PA 19107 USA.
   [Mensah, George] NIH, Bethesda, MD 20892 USA.
   [Mhimbira, Francis A.] Ifakara Hlth Inst, Dar Es Salaam, Tanzania.
   [Micha, Renata; Mozaffarian, Dariush] Friedman Sch Nutr Sci & Policy, Medford, MA USA.
   [Shi, Peilin] Tufts Univ, Medford, MA 02155 USA.
   [Miller, Ted R.] Pacific Inst Res & Evaluat, Calverton, MD USA.
   [Miller, Ted R.] Curtin Univ, Ctr Populat Hlth Res, Perth, WA 6845, Australia.
   [Mills, Edward J.] Univ Ottawa, Ottawa, ON, Canada.
   [Moffitt, Terrie E.] Duke Univ, Durham, NC USA.
   [Ibrahim, Norlinah Mohamed] Univ Kebangsaan Malaysia, Med Ctr, Dept Med, Kuala Lumpur, Malaysia.
   [Mohammad, Karzan A.] Univ Salahaddin, Erbil, Iraq.
   [Mola, Glen L.] Univ Papua New Guinea, Port Moresby, Papua N Guinea.
   [Moore, Ami R.] Univ N Texas, Denton, TX 76203 USA.
   [Morawska, Lidia] Queensland Univ Technol, Int Lab Air Qual & Hlth, Brisbane, Qld 4001, Australia.
   [Mori, Rintaro] Natl Ctr Child Hlth & Dev, Setagaya Ku, Tokyo, Japan.
   [Moschandreas, Joanna; Tsilimbaris, Miltiadis] Univ Crete, Dept Med, Iraklion, Greece.
   [Moturi, Wilkister N.] Egerton Univ, Egerton, Rift Valley, Kenya.
   [Mueller, Ulrich O.] Univ Marburg, Marburg, Germany.
   [Mukaigawara, Mitsuru] Tokyo Med & Dent Univ, Bunkyo Ku, Tokyo, Japan.
   [Murdoch, Michele E.] West Hertfordshire Hosp NHS Trust, Hempstead, Herts, England.
   [Nahas, Ziad] Amer Univ Beirut, Med Ctr, Beirut, Lebanon.
   [Naidoo, Kovin S.] Univ KwaZulu Natal, Durban, Kwazulu Natal, South Africa.
   [Naldi, Luigi] Azienda Osped Papa Giovanni XXIII, Bergamo, Italy.
   [Nand, Devina] Minist Hlth Fiji, Suva, Fiji.
   [Nangia, Vinay] Suraj Eye Inst, Nagpur, Maharashtra, India.
   [Simard, Edgar P.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Narayan, K. M. Venkat; Omer, Saad B.; Phillips, Michael R.] Emory Univ, Atlanta, GA 30322 USA.
   [Nash, Denis] CUNY, Sch Publ Hlth, New York, NY 10021 USA.
   [Nejjari, Chakib] Fac Med, Fes, Morocco.
   [Neupane, Sudan P.] Univ Oslo, Norwegian Ctr Addict Res SERAF, Oslo, Norway.
   [Rakovac, Ivo] WHO Reg Off Europe, Copenhagen, Denmark.
   [Newman, Lori M.] WHO, CH-1211 Geneva, Switzerland.
   [Newton, Charles R.] KEMRI Wellcome Trust, Kilifi, Kenya.
   [Ngalesoni, Frida N.] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania.
   [Nhung, Nguyen T.] Hanoi Sch Publ Hlth, Hanoi, Vietnam.
   [Norheim, Ole F.] Univ Bergen, Bergen, Norway.
   [Norrving, Bo] Lund Univ, Fac Med, Dept Clin Sci, Lund, Sweden.
   [Nyakarahuka, Luke] Makerere Univ, Kampala, Uganda.
   [Oh, In Hwan] Kyung Hee Univ, Seoul, South Korea.
   [Ohkubo, Takayoshi] Teikyo Univ, Sch Med, Itabashi Ku, Tokyo 173, Japan.
   [Opio, John Nelson] Lira Municipal Council, Lira Dist Local Govt, Northern Uganda, Uganda.
   [Ortiz, Alberto] Fdn Jimenez Diaz, IIS, E-28040 Madrid, Spain.
   [Pandian, Jeyaraj D.] Christian Med Coll Ludhiana, Ludhiana, Punjab, India.
   [Park, Eun-Kee] Kosin Univ, Coll Med, Busan, South Korea.
   [Pereira, David M.] Univ Porto, Fac Farm, REQUIMTE Lab Farmacognosia, Dept Quam, P-4100 Oporto, Portugal.
   [Perez-Ruiz, Fernando P.] Hosp Univ Cruces, Baracaldo, Bizkaia, Spain.
   [Perez-Ruiz, Fernando P.] Biocruces Hlth Res Inst, Baracaldo, Bizkaia, Spain.
   [Pervaiz, Aslam] Postgrad Med Inst, Lahore, Pakistan.
   [Pesudovs, Konrad] Flinders Univ S Australia, Bedford Pk, SA 5042, Australia.
   [Peterson, Carrie B.] Aalborg Univ, Aalborg, Denmark.
   [Petzold, Max] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa.
   [Phillips, Michael R.] Shanghai Jiao Tong Univ, Shanghai 200030, Peoples R China.
   [Poenaru, Dan] McMaster Univ, Hamilton, ON, Canada.
   [Pope, C. A., III] Brigham Young Univ, Provo, UT 84602 USA.
   [Popova, Svetlana; Rehm, Jurgen] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Prasad, Noela M.] Fred Hollows Fdn, Sydney, NSW, Australia.
   [Qato, Dima] Univ Illinois, Coll Pharm, Chicago, IL USA.
   [Rafay, Anwar] Contech Int, Lahore, Pakistan.
   [Rahman, Sajjad Ur] Hamad Med Corp, Doha, Qatar.
   [Raju, Murugesan] Univ Missouri, Columbia, MO USA.
   [Rana, Saleem M.] Univ Punjab, Dept Publ Hlth, Lahore, Pakistan.
   [Razavi, Homie] Ctr Dis Anal, Louisville, CO USA.
   [Refaat, Amany] Walden Univ, Minneapolis, MN USA.
   [Resnikoff, Serge] Int Hlth & Dev, Zurich, Switzerland.
   [Ribeiro, Antonio L.] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil.
   [Velasquez-Melendez, Gustavo] Univ Fed Minas Gerais, Escola Enfermagem, Belo Horizonte, MG, Brazil.
   [Riccio, Patricia M.] Univ Western Ontario, Dept Clin Neurol Sci, London Hlth Sci Ctr, London, ON, Canada.
   [Roca, Anna] MRC Unit, Fajara, Gambia.
   [Rojas-Rueda, David] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
   [Rothenbacher, Dietrich] Univ Ulm, Inst Epidemiol & Med Biometry, D-89069 Ulm, Germany.
   [Roy, Nobhojit] BARC Hosp, Mumbai, Maharashtra, India.
   [Ruhago, George M.; Sunguya, Bruno F.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
   [Sabin, Nsanzimana] Rwanda Biomed Ctr, Kigali, Rwanda.
   [Sacco, Ralph L.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Saha, Sukanta] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld, Australia.
   [Sahathevan, Ramesh] Univ Kebangsaan Malaysia, Med Ctr, Bangi 43600, Selangor, Malaysia.
   [Sampson, Uchechukwu] Vanderbilt Univ, Nashville, TN 37235 USA.
   [Sanabria, Juan R.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [Sanchez-Riera, Lidia] Mafraq Hosp SEHA, Abu Dhabi, U Arab Emirates.
   [Saunders, James E.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA.
   [Sawhney, Monika] Marshall Univ, Huntington, WV USA.
   [Saylan, Mete I.] Novartis, Istanbul, Turkey.
   [Schneider, Ione J. C.] Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
   [Schwebel, David C.; Singh, Jasvinder A.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Seedat, Soraya] Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa.
   [Serdar, Berrin] Univ Colorado, Boulder, CO 80309 USA.
   [Shaheen, Amira] An Najah Univ, Nablus, Israel.
   [Shibuya, Kenji] Univ Tokyo, Tokyo, Japan.
   [Shinohara, Yukito] Tachikawa Hosp, Tokyo, Japan.
   [Shiri, Rahman] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Shishani, Kawkab] Washington State Univ, Pullman, WA 99164 USA.
   [Shiue, Ivy] Heriot Watt Univ, Edinburgh, Midlothian, Scotland.
   [Sigfusdottir, Inga D.] Reykjavik Univ, Reykjavik, Iceland.
   [Soneji, Samir] Dartmouth Coll, Hanover, NH USA.
   [Ksoreide, Kjetil] Stavanger Univ Hosp, Stavanger, Norway.
   [Soshnikov, Sergey S.] Minist Hlth Russian Federat, Fed Res Inst Hlth Org & Informat, Moscow, Russia.
   [Sposato, Luciano A.] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada.
   [Sreeramareddy, Chandrashekhar T.] Univ Tunku Abdul Rahman, Fac Med & Hlth Sci, Selangor, Malaysia.
   [Stathopoulou, Vasiliki Kalliopi] Ctr Hosp Nord Deux Sevres, Bressuire, France.
   [Steckling, Nadine] Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
   [Stovner, Lars J.] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway.
   [Steiner, Timothy J.] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway.
   [Stroumpoulis, Konstantinos] Alexandra Gen Hosp Athens, KEELPNO, Ctr Dis Control, Athens, Greece.
   [Swaroop, Mamta] Northwestern Univ, Evanston, IL USA.
   [Sykes, Bryan L.] Univ Calif Irvine, Dept Criminol Law & Soc & Sociol, Irvine, CA USA.
   [Tabb, Karen M.] Univ Illinois, Urbana, IL 61801 USA.
   [Tan, Feng] China CDC, Natl Inst Occupat Hlth & Poison Control, Beijing, Peoples R China.
   [Tanne, David] Chaim Sheba Med Ctr, Tel Aviv, Israel.
   [Tanne, David] Tel Aviv Univ, IL-69978 Tel Aviv, Israel.
   [Tavakkoli, Mohammad] Westchester Cty Med Ctr, Valhalla, NY 10595 USA.
   [Temesgen, Awoke Misganaw] Jhpiego, Addis Ababa, Ethiopia.
   [Ten Have, Margreet] Netherlands Inst Mental Hlth & Addict, Utrecht, Netherlands.
   [Tenkorang, Eric Yeboah] Mem Univ Newfoundland, St John, NF, Canada.
   [Terkawi, Abdullah Sulieman] King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia.
   [Tleyjeh, Imad M.] King Fahad Med City, Coll Med, Riyadh, Saudi Arabia.
   [Thorne-Lyman, Andrew L.] Saudi Arabial WorldFish, George Town, Malaysia.
   [Tonelli, Marcello] Univ Alberta, Edmonton, AB, Canada.
   [Topouzis, Fotis] Aristotle Univ Thessaloniki, GR-54006 Thessaloniki, Greece.
   [Towbin, Jeffrey A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Toyoshima, Hideaki] Anjo Kosei Hosp, Hlth Care Ctr, Anjo City, Aichi, Japan.
   [Traebert, Jefferson] Univ Southern Santa Catarina, Palhoca, SC, Brazil.
   [Truelsen, Thomas] Copenhagen Univ Hosp Herlev, Dept Neurol, Copenhagen, Denmark.
   [Trujillo, Ulises] Serv Canario Salud, Tenerife, Spain.
   [Tuzcu, Emin M.] Cleveland Clin, Cleveland, OH 44106 USA.
   [Ukwaja, Kingsley N.] Fed Teaching Hosp Abakaliki, Dept Internal Med, Abakaliki, Ebonyi State, Nigeria.
   [van Brakel, Wim H.] Netherlands Leprosy Relief, Delft, Netherlands.
   [de Vijver, Steven van] African Populat & Hlth Res Ctr, Nairobi, Kenya.
   [Van Dingenen, Rita] Commiss European Communities, Joint Res Ctr, I-21020 Ispra, Italy.
   [van Gool, Coen H.] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
   [Varakin, Yuri Y.] Res Ctr Neurol, Moscow, Russia.
   [Vasankari, Tommi J.] UKK Inst Hlth Promot Res, Tampere, Finland.
   [Venketasubramanian, Narayanaswamy] Raffles Hosp, Ctr Neurosci, Singapore, Singapore.
   [Vijayakumar, Lakshmi] Voluntary Hlth Serv, Sneha, India.
   [Violante, Francesco S.] Univ Bologna, Bologna, Italy.
   [Vlassov, Vasiliy V.] Higher Sch Econ, Moscow, Russia.
   [Waller, Stephen] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Wallin, Mitchell T.] VA Med Ctr, Washington, DC USA.
   [Wan, Xia] Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China.
   [Wang, Yanping] Natl Off Maternal & Childs Hlth Surveillance, Chengdu, Peoples R China.
   [Weichenthal, Scott] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
   [Werdecker, Andrea] Inst Med Sociol & Social Med, Berlin, Germany.
   [Wessells, K. Ryan R.] Univ Calif Davis, Davis, CA 95616 USA.
   [Westerman, Ronny] Univ Marburg, Hessen, Germany.
   [Wilkinson, James D.] Univ Miami, Miami, FL USA.
   [Williams, Thomas N.] Univ London Imperial Coll Sci Technol & Med, London, England.
   [Williams, Hywel C.] Univ Nottingham, Nottingham NG7 2RD, England.
   [Woldeyohannes, Solomon M.] Univ Gondar, Inst Publ Hlth, Amhara, Ethiopia.
   [Wong, John Q.] Ateneo Sch Med & Publ Hlth, Manila, Philippines.
   [Woolf, Anthony D.] Royal Cornwall Hosp, Truro, Cornwall, England.
   [Xu, Gelin; Yang, Gonghuan] Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210008, Jiangsu, Peoples R China.
   [Yano, Yuichiro] Jichi Med Univ, Sch Med, Div Cardiovasc Med, Shimotsuke, Tochigi, Japan.
   [Yentur, Gokalp K.] Gen Directorate Hlth Res, Ankara, Turkey.
   [Yip, Paul] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
   [Yonemoto, Naohiro] Natl Ctr Neurol & Psychiat, Kodaira, Tokyo, Japan.
   [Younis, Mustafa] Jackson State Univ, Jackson, MS USA.
   [Yu, Chuanhua] Wuhan Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430072, Hubei, Peoples R China.
   [Yu, Chuanhua] Wuhan Univ, Global Hlth Inst, Wuhan 430072, Hubei, Peoples R China.
   [Kim, Kim Yun] TCM Med TK SDN BHD TCM, Nusajaya, Johor Bahru, Malaysia.
   [Zaki, Maysaa El Sayed] Mansoura Sch Med, Mansoura, Egypt.
   [Zhao, Yong] Chongqing Med Univ, Chongqing, Peoples R China.
   [Zhu, Jun] Natl Off MCH Surveillance China, Beijing, Peoples R China.
   [Zonies, David] Landstuhl Reg Med Ctr, Landstuhl, Germany.
RP Vos, T (reprint author), Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.
EM tvos@uw.edu
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FU Lundbeck and Auckland University of Technology University; Bill &
   Melinda Gates Foundation; Ministry of Health, Labour and Welfare of
   Japan; Australian National health and Medical Research Council (NHMRC)
   [1041742]; Japan Society of Clinical Pharmacology and Therapeutics;
   National Heart Foundation, Australia; Wellcome Trust [091758, 095066,
   089963/Z/09/Z, 099876]; Health Protection Scotland; National Institute
   for Health Research (NIHR) Health Protection Research Unit (HPRU) in
   Evaluation of Interventions, and Sexual Health 24; WHO; University of
   Illinois, Lemann Institute for Brazilian Studies Faculty Research Grant;
   NIHR Oxford BRC; NIHR; CIBERSAM; Instituto de Salud Carlos III; Spanish
   Ministry of Economy and Competitiveness, Madrid, Spain; Qatar National
   Research Fund [NPRP 04-924-3-251]; joint US National Institutes of
   Health-National Science Foundation Ecology and Evolution of Infectious
   Disease program [R01 TW009237]; UK Biotechnology and Biological Sciences
   Research Council (BBSRC) [BB/J010367/1]; UK BBSRC Zoonoses in Emerging
   Livestock Systems awards [BB/L017679, BB/L018926, BB/L018845];
   Queensland Department of Health; VIROPHARMA; EISAI; UCB-Pharma;
   GlaxoSmithKline; Italian Drug Agency; Italian Ministry of Health;
   Sanofi-Aventis; American ALS Association; Wellcome Trust; NIHR
   Biomedical Research Centre at Guy's and St Thomas' National Health
   Service Foundation Trust and King's College London - NIHR; Abbott;
   ABMRF; Astrazeneca; Biocodex; Eli-Lilly; Jazz Pharmaceuticals; Johnson
   Johnson; Lundbeck; National Responsible Gambling Foundation; Novartis;
   Orion; Pfizer; Pharmacia; Roche; Servier; Solvay; Sumitomo; Sun; Takeda;
   Tikvah; Wyeth; Medical Research Council of South Africa; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development of the
   National Institutes of Health [5T32HD057822]; Public Health Foundation
   of India; consortium of UK universities; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo
   a Pesquisa do Estado do Rio Grande do Sul (FAPERGS); Farr Institute at
   CIPHER; Arthritis Research UK; British Heart Foundation; Cancer Research
   UK; Economic and Social Research Council; Engineering and Physical
   Sciences Research Council; Medical Research Council; National Institute
   of Health Research; National Institute for Social Care and Health
   Research (Welsh Assembly Government); Chief Scientist Office (Scottish
   Government Health Directorates); MRC [MR/K006525/1]; Savient; Regeneron;
   Allergan; American College of Rheumatology's Guidelines Subcommittee of
   the Quality of Care Committee; Veterans Affairs Rheumatology Field
   Advisory Committee; National Health and Medical Research of Australia;
   NIH, the National Institute of Environmental Health Sciences; Brien
   Holden Vision Institute; Victorian Articles 56 Government; Korean Health
   Technology research and development project, Ministry of Health and
   Welfare, North Korea [HI13C0729]; NIH; Commonwealth Government of
   Australia; Institute of Bone and Joint Research; Crucell; Merck; Sanofi
   Pasteur; NIH [R01 DA 003574]; Oklahoma Center for the Advancement of
   Science and Technology; NIHR Career Development Fellowship; Wellcome
   Trust Training Fellowship [099876]; South African Medical Research
   Council
FX Bill & Melinda Gates Foundation.; This study was funded by the Bill &
   Melinda Gates Foundation. VF and RK were partly supported by the
   unrestricted educational grant from Lundbeck and Auckland University of
   Technology University. RM received funding from Ministry of Health,
   Labour and Welfare of Japan. LD is supported by an Australian National
   health and Medical Research Council (NHMRC) Principal Research
   Fellowship (#1041742). Work by NY was supported by funding from the
   Japan Society of Clinical Pharmacology and Therapeutics. YK would like
   to thank the National Heart Foundation, Australia, for extending a
   special grant to the University of Canberra that enabled him to
   participate in the GBD 2013 study and more broadly engage in research on
   cardiovascular conditions in Australia. TW would like to acknowledge the
   Wellcome Trust, through whom he is supported through a Senior Research
   Fellowship number 091758. During the study, KJL received funding from
   Health Protection Scotland, the National Institute for Health Research
   (NIHR) Health Protection Research Unit (HPRU) in Evaluation of
   Interventions, and Sexual Health 24. KJL received funding from WHO to
   conduct the review of HSV.2 seroprevalence data that informed this
   study. GR's contribution to this paper has been on behalf of the
   International Society of Nephrology (ISN), as a follow-up of the
   activities of the GBD 2010 Genitourinary Diseases Expert Group. KTD
   would like to acknowledge the following funding source of institutional
   support: University of Illinois, Lemann Institute for Brazilian Studies
   Faculty Research Grant. KR is supported by the NIHR Oxford BRC and an
   NIHR Career Development Fellowship. FC-L would like to thank funding
   support by Spanish Ministry of Economy and Competitiveness, Madrid,
   Spain, Instituto de Salud Carlos III, Spanish Ministry of Economy and
   Competitiveness, Madrid, Spain. LJAR would like to acknowledge the
   support of Qatar National Research Fund (NPRP 04-924-3-251) who provided
   the main funding for generating the data provided to the GBD-IHME
   effort. MBS is a member of the board of directors of the Anxiety and
   Depression Association of America (a non-profit professional and
   consumer organization). He has in the past 24 months been a consultant
   for companies that either market or are conducting research involving
   antidepressant or antianxiety medications: Janssen, Pfizer, and Tonix
   Pharmaceuticals. JAC is supported by the joint US National Institutes of
   Health-National Science Foundation Ecology and Evolution of Infectious
   Disease program (R01 TW009237) and the UK Biotechnology and Biological
   Sciences Research Council (BBSRC) (BB/J010367/1), and by UK BBSRC
   Zoonoses in Emerging Livestock Systems awards BB/L017679, BB/L018926,
   and BB/L018845. HW, AF, FC, and HE are affiliated with the Queensland
   Centre for Mental Health Research, which receives funding from the
   Queensland Department of Health. EB has received money for board
   membership by VIROPHARMA and EISAI; funding for travel and speaker
   honoraria from UCB-Pharma and GlaxoSmithKline and funding for
   educational presentations from GlaxoSmithKline; grants for research
   activities from the Italian Drug Agency, Italian Ministry of Health,
   Sanofi-Aventis, and the American ALS Association. ML would like to
   acknowledge the institutional support received from CeRIMP, Centro
   Regionale Infortuni e Malattie Professionali Regione Toscana (via
   S.Salvi, 12 - 50135 Firenze - Italy). AB would like to acknowledge
   funding from the Wellcome Trust.; CW was supported by the NIHR
   Biomedical Research Centre at Guy's and St Thomas' National Health
   Service Foundation Trust and King's College London, funded by the NIHR.
   DS has received research grants or consultancy honoraria from Abbott,
   ABMRF, Astrazeneca, Biocodex, Eli-Lilly, GlaxoSmithKline, Jazz
   Pharmaceuticals, Johnson & Johnson, Lundbeck, National Responsible
   Gambling Foundation, Novartis, Orion, Pfizer, Pharmacia, Roche, Servier,
   Solvay, Sumitomo, Sun, Takeda, Tikvah, and Wyeth. DS would like to
   acknowledge support by the Medical Research Council of South Africa. DAQ
   was supported by the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development of the National Institutes of Health under
   award number 5T32HD057822. The content of this report is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. PJ is supported by
   a career development fellowship from the Wellcome Trust, Public Health
   Foundation of India and a consortium of UK universities. CK receives
   research grants from Brazilian public funding agencies Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), and Fundacao de
   Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS). He has also
   received authorship royalties from publishers Artmed and Manole. RAL is
   partly funded through the Farr Institute at CIPHER. The Farr Institute
   at CIPHER is supported by a ten-funder consortium: Arthritis Research
   UK, the British Heart Foundation, Cancer Research UK, the Economic and
   Social Research Council, the Engineering and Physical Sciences Research
   Council, the Medical Research Council, the National Institute of Health
   Research, the National Institute for Social Care and Health Research
   (Welsh Assembly Government), the Chief Scientist Office (Scottish
   Government Health Directorates), the Wellcome Trust, (MRC Grant No:
   MR/K006525/1). JAS has received research grants from Takeda and Savient
   and consultant fees from Savient, Takeda, Regeneron and Allergan. JAS is
   a member of the executive of OMERACT, an organisation that develops
   outcome measures in rheumatology and receives arms-length funding from
   36 companies; a member of the American College of Rheumatology's
   Guidelines Subcommittee of the Quality of Care Committee; and a member
   of the Veterans Affairs Rheumatology Field Advisory Committee. SIH is
   funded by a Wellcome Trust Grant (#095066). JM is funded as a Research
   Career Development Fellow from the Wellcome Trust (#089963/Z/09/Z). RL
   is supported by a National Health and Medical Research of Australia
   Fellowship. KK thanks the Director of International Institute for
   Population Sciences (IIPS) for giving KK the opportunity to do PhD at
   the IIPS, during which KK got the chance to become a GBD Study 2013
   collaborator. HC is supported by the Intramural Research Program of the
   NIH, the National Institute of Environmental Health Sciences. The GBD
   Vision Loss Expert Group received additional funding from Brien Holden
   Vision Institute. NP has an honorary position with the University of
   Melbourne, through the Centre for Eye Research Australia (CERA), and is
   employed by the Fred Hollows Foundation (FHF). Access to information on
   population-based prevalence studies from the countries they support work
   in was primarily as a result of her work at FHF, and the review of the
   manuscript and revisions suggested were a part of her position at CERA.;
   CERA receives Operational Infrastructure CERA receives Operational
   Infrastructure Support funding from the Victorian Articles 56
   Government. I-HO and S-JY's work was funded by a grant of the Korean
   Health Technology research and development project, Ministry of Health
   and Welfare, North Korea (grant number HI13C0729). SS is supported by
   grants from the NIH and employed by NRF and has honoraria from
   pharmaceutical companies. KD is supported by a Wellcome Trust Fellowship
   in Public Health and Tropical Medicine (grant number 099876). LM would
   like to acknowledge the Commonwealth Government of Australia and the
   Institute of Bone and Joint Research as funders of this work as all the
   original data collection for musculoskeletal was funded by these
   sources. BDG works for Agence de Medecine Preventive which receives
   grant specific support from Crucell, GlaxoSmithKline, Merck, Novartis,
   and Sanofi Pasteur. None of these sources contributed to the current
   work. MGS previously served as a consultant for Ellicon. DCDJ was
   supported by NIH grant R01 DA 003574. LJA-R would like to acknowledge
   the Qatar National Research Fund (NPRP 04-924-3-251) who provided the
   main funding for generating the data he provided to the GBD-IHME effort.
   The GBD Genitourinary Diseases Expert Group's activities with the GBD
   2013 have been made on behalf of the International Society of
   Nephrology. AK would like to acknowledge funding support from Oklahoma
   Center for the Advancement of Science and Technology. KR is supported by
   the NIHR Oxford BRC and an NIHR Career Development Fellowship. KD is
   supported by a Wellcome Trust Training Fellowship (grant number 099876).
   KS would like to acknowledge funding from the South African Medical
   Research Council. IR and WHO staff acknowledge that the authors alone
   are responsible for the views expressed in this article and they do not
   necessarily represent the views, decisions or policies of the
   institutions with which they are affiliated.
NR 102
TC 573
Z9 586
U1 128
U2 385
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD AUG 22
PY 2015
VL 386
IS 9995
BP 743
EP 800
DI 10.1016/S0140-6736(15)60692-4
PG 58
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ0LR
UT WOS:000360287900025
ER

PT J
AU Yooseph, S
   Kirkness, EF
   Tran, TM
   Harkins, DM
   Jones, MB
   Torralba, MG
   O'Connell, E
   Nutman, TB
   Doumbo, S
   Doumbo, OK
   Traore, B
   Crompton, PD
   Nelson, KE
AF Yooseph, Shibu
   Kirkness, Ewen F.
   Tran, Tuan M.
   Harkins, Derek M.
   Jones, Marcus B.
   Torralba, Manolito G.
   O'Connell, Elise
   Nutman, Thomas B.
   Doumbo, Safiatou
   Doumbo, Ogobara K.
   Traore, Boubacar
   Crompton, Peter D.
   Nelson, Karen E.
TI Stool microbiota composition is associated with the prospective risk of
   Plasmodium falciparum infection
SO BMC GENOMICS
LA English
DT Article
DE Stool microbiota; Gut microbiota; Malaria; 16S rRNA gene sequencing;
   Plasmodium falciparum; Human; Prospective cohort
ID GUT MICROBIOTA; INTESTINAL MICROBIOTA; MILK OLIGOSACCHARIDES; MALARIA;
   IMMUNITY; CHILDREN; MALI; MECHANISMS; PROTECTION; BACTERIA
AB Background: In humans it is unknown if the composition of the gut microbiota alters the risk of Plasmodium falciparum infection or the risk of developing febrile malaria once P. falciparum infection is established. Here we collected stool samples from a cohort composed of 195 Malian children and adults just prior to an intense P. falciparum transmission season. We assayed these samples using massively parallel sequencing of the 16S ribosomal RNA gene to identify the composition of the gut bacterial communities in these individuals. During the ensuing 6-month P. falciparum transmission season we examined the relationship between the stool microbiota composition of individuals in this cohort and their prospective risk of both P. falciparum infection and febrile malaria.
   Results: Consistent with prior studies, stool microbial diversity in the present cohort increased with age, although the overall microbiota profile was distinct from cohorts in other regions of Africa, Asia and North America. Age-adjusted Cox regression analysis revealed a significant association between microbiota composition and the prospective risk of P. falciparum infection; however, no relationship was observed between microbiota composition and the risk of developing febrile malaria once P. falciparum infection was established.
   Conclusions: These findings underscore the diversity of gut microbiota across geographic regions, and suggest that strategic modulation of gut microbiota composition could decrease the risk of P. falciparum infection in malaria-endemic areas, potentially as an adjunct to partially effective malaria vaccines.
C1 [Yooseph, Shibu; Jones, Marcus B.; Nelson, Karen E.] J Craig Venter Inst, La Jolla, CA 92037 USA.
   [Kirkness, Ewen F.; Harkins, Derek M.; Torralba, Manolito G.] J Craig Venter Inst, Rockville, MD 20850 USA.
   [Tran, Tuan M.; Crompton, Peter D.] NIAID, Immunogenet Lab, Div Intramural Res, NIH, Rockville, MD 20852 USA.
   [O'Connell, Elise; Nutman, Thomas B.] NIAID, Lab Parasit Dis, Div Intramural Res, NIH, Rockville, MD 20852 USA.
   [Doumbo, Safiatou; Doumbo, Ogobara K.; Traore, Boubacar] Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Int Ctr Excellence Res, Bamako, Mali.
RP Crompton, PD (reprint author), NIAID, Immunogenet Lab, Div Intramural Res, NIH, Rockville, MD 20852 USA.
EM pcrompton@niaid.nih.gov; kenelson@jcvi.org
RI Crompton, Peter/N-1130-2016
FU National Institute of Allergy and Infectious Diseases, National
   Institutes of Health, Department of Health and Human Services
   [HHSN272200900007C]; Division of Intramural Research, National Institute
   of Allergy and Infectious Diseases, National Institutes of Health [1 ZIA
   AI001126]
FX This project was funded with federal funds from the National Institute
   of Allergy and Infectious Diseases, National Institutes of Health,
   Department of Health and Human Services, under contract number
   HHSN272200900007C (PI: Karen E. Nelson). The cohort study in Mali was
   supported by the Division of Intramural Research, National Institute of
   Allergy and Infectious Diseases, National Institutes of Health, under 1
   ZIA AI001126 (PI: Peter D. Crompton).
NR 46
TC 4
Z9 4
U1 0
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD AUG 22
PY 2015
VL 16
AR 631
DI 10.1186/s12864-015-1819-3
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CP4FN
UT WOS:000359837500004
PM 26296559
ER

PT J
AU Colegate, SM
   Boppre, M
   Monzon, J
   Betz, JM
AF Colegate, Steven M.
   Boppre, Michael
   Monzon, Julio
   Betz, Joseph M.
TI Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean
   herbal medicine "asmachilca"
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Asmachilca; Herbal tea; Aristeguietia gayana; Eupatorium;
   1,2-Dehydropyrrolizidine alkaloids; Pyrrolizidine alkaloids;
   Hepatotoxicity; Rinderine; Supinine; Intermedine; Asmachilcadine;
   Asmachilcadinine
ID PYRROLIZIDINE ALKALOIDS; N-OXIDES; HONEY; EXTRACTION; FOOD; TEA
AB Ethnopharmacological relevance: Asmachilca is a Peruvian medicinal herb preparation ostensibly derived from Aristeguietia gayana (Wedd.) R.M. King & H. Rob. (Asteraceae: Eupatorieae). Decoctions of the plant have a reported bronchodilation effect that is purported to be useful in the treatment of respiratory allergies, common cold and bronchial asthma. However, its attractiveness to pyrrolizidine alkaloid-pharmacophagous insects indicated a potential for toxicity for human consumers.
   Aim of the study: To determine if commercial asmachilca samples, including fully processed herbal teas, contain potentially toxic 1,2-dehydropyrrolizidine alkaloids.
   Materials and methods: Two brands of "Asmachilca" herbal tea bags and four other commercial samples of botanical materials for preparing asmachilca medicine were extracted and analyzed using HPLC-esi (+)MS and MS/MS for the characteristic retention times and mass spectra of known dehydropyrrolizidine alkaloids. Other suspected dehydropyrrolizidine alkaloids were tentatively identified based on MS/MS profiles and high resolution molecular weight determinations. Further structure elucidation of isolated alkaloids was based on 1D and 2D NMR spectroscopy.
   Results: Asmachilca attracted many species of moths which are known to pharmacophagously gather dehydropyrrolizidine alkaloids. Analysis of 5 of the asmachilca samples revealed the major presence of the dehydropyrrolizidine alkaloid monoesters rinderine and supinine, and their N-oxides. The 6th sample was very similar but did not contain supinine or its N-oxide. Small quantities of other dehydropyrrolizidine alkaloid monoesters, including echinatine and intermedine, were also detected. In addition, two major metabolites, previously undescribed, were isolated and identified as dehydropyrrolizidine alkaloid monoesters with two "head-to-tail" linked viridifloric and/or trachelanthic acids. Estimates of total pyrrolizidine alkaloid and N-oxide content in the botanical components of asmachilca varied from 0.4% to 0.9% (w/dw, dry weight) based on equivalents of lycopsamine. The mean pyrrolizidine alkaloid content of a hot water infusion of a commercial asmachilca herbal tea bag was 2.2 +/- 0.5 mg lycopsamine equivalents. Morphological and chemical evidence showed that asmachilca is prepared from different plant species.
   Conclusions: All asmachilca samples and the herbal tea infusions contained toxicologically-relevant concentrations of pro-toxic 1,2-dehydropyrrolizidine alkaloid esters and, therefore, present a risk to the health of humans. This raises questions concerning the ongoing unrestricted availability of such products on the Peruvian and international market. In addition to medical surveys of consumers of asmachilca, in the context of chronic disease potentially associated with ingestion of the dehydropyrrolizidine alkaloids, the botanical origins of asmachilca preparations require detailed elucidation. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Colegate, Steven M.] ARS, USDA, Poisonous Plant Res Lab, Logan, UT 84341 USA.
   [Colegate, Steven M.] Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA.
   [Boppre, Michael; Monzon, Julio] Univ Freiburg, Forstzool & Entomol, D-79085 Freiburg, Germany.
   [Betz, Joseph M.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
RP Colegate, SM (reprint author), ARS, USDA, Poisonous Plant Res Lab, Logan, UT 84341 USA.
EM steven.colegate@usu.edu
RI Boppre, Michael/P-4346-2016
FU Intramural NIH HHS [Z99 OD999999]
NR 49
TC 3
Z9 3
U1 3
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD AUG 22
PY 2015
VL 172
BP 179
EP 194
DI 10.1016/j.jep.2015.06.012
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA CP4TQ
UT WOS:000359875900019
PM 26087231
ER

PT J
AU Gelfand, JM
   Mehta, NN
AF Gelfand, Joel M.
   Mehta, Nehal N.
TI Aortic valve stenosis: a new cardiovascular comorbidity of psoriasis?
SO EUROPEAN HEART JOURNAL
LA English
DT Editorial Material
ID POPULATION-BASED COHORT; VASCULAR INFLAMMATION; RHEUMATOID-ARTHRITIS;
   INCREASED RISK; FDG-PET/CT; MODERATE; SKIN
C1 [Gelfand, Joel M.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Mehta, Nehal N.] NHLBI, NIH, Bethesda, MD 20892 USA.
RP Gelfand, JM (reprint author), Univ Penn, Perelman Sch Med, One Convent Ave,1471 Penn Tower, Philadelphia, PA 19104 USA.
EM Joel.Gelfand@uphs.upenn.edu
FU NHLBI NIH HHS [R01 HL111293]; NIAMS NIH HHS [K24 AR064310]
NR 15
TC 2
Z9 2
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD AUG 21
PY 2015
VL 36
IS 32
BP 2134
EP 2135
DI 10.1093/eurheartj/ehv271
PG 2
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA CQ5CG
UT WOS:000360620300007
PM 26074463
ER

PT J
AU Hinz, JM
   Mao, P
   McNeill, DR
   Wilson, DM
AF Hinz, John M.
   Mao, Peng
   McNeill, Daniel R.
   Wilson, David M., III
TI Reduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (
   APE1)Variants on Nucleosomes IDENTIFICATION OF ACCESS RESIDUES
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID BASE EXCISION-REPAIR; URACIL-DNA GLYCOSYLASE; GLUCOCORTICOID RESPONSE
   ELEMENT; CORE PARTICLES; MAJOR HUMAN; BINDING; APE1; ACCESSIBILITY;
   COORDINATION; PROTEIN
AB Non-coding apurinic/apyrimidinic (AP) sites are generated at high frequency in genomic DNA via spontaneous hydrolytic, damage-induced or enzyme-mediated base release. AP endonuclease 1 (APE1) is the predominant mammalian enzyme responsible for initiating removal of mutagenic and cytotoxic abasic lesions as part of the base excision repair (BER) pathway. We have examined here the ability of wild-type (WT) and a collection of variant/mutant APE1 proteins to cleave at an AP site within a nucleosome core particle. Our studies indicate that, in comparison to the WT protein and other variant/mutant enzymes, the incision activity of the tumor-associated variant R237C and the rare population variant G241R are uniquely hypersensitive to nucleosome complexes in the vicinity of the AP site. This defect appears to stem from an abnormal interaction of R237C and G241R with abasic DNA substrates, but is not simply due to a DNA binding defect, as the site-specific APE1 mutant Y128A, which displays markedly reduced AP-DNA complex stability, did not exhibit a similar hypersensitivity to nucleosome structures. Notably, this incision defect of R237C and G241R was observed on a pre-assembled DNA glycosylase.AP-DNA complex as well. Our results suggest that the BER enzyme, APE1, has acquired distinct surface residues that permit efficient processing of AP sites within the context of protein-DNA complexes independent of classic chromatin remodeling mechanisms.
C1 [Hinz, John M.; Mao, Peng] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA.
   [McNeill, Daniel R.; Wilson, David M., III] NIA, Lab Mol Gerontol, IRP, NIH, Baltimore, MD 21224 USA.
RP Hinz, JM (reprint author), Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA.
EM jmhinz@wsu.edu
RI Regan, Clinton/E-6250-2012
FU National Institutes of Health [ES020955, ES004106, ES002614]; National
   Institute of Environmental Health Sciences; Intramural Research Program
   at the National Institutes of Health, NIA
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants ES020955 (to J. M. H.) and ES004106 and ES002614 (to M.
   Smerdon, Washington State University)), from the National Institute of
   Environmental Health Sciences, and the Intramural Research Program at
   the National Institutes of Health, NIA. The authors declare that they
   have no conflicts of interest with the contents of this article.
NR 43
TC 3
Z9 3
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 21
PY 2015
VL 290
IS 34
BP 21067
EP 21075
DI 10.1074/jbc.M115.665547
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CP6QC
UT WOS:000360011800039
PM 26134573
ER

PT J
AU Berezhkovskii, AM
   Shvartsman, SY
AF Berezhkovskii, Alexander M.
   Shvartsman, Stanislav Y.
TI Dynamics of gradient formation by intracellular shuttling
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
AB A number of important cellular functions rely on the formation of intracellular protein concentration gradients. Experimental studies discovered a number of mechanisms for the formation of such gradients. One of the mechanisms relies on the intracellular shuttling of a protein that interconverts between the two states with different diffusivities, under the action of two enzymes, one of which is localized to the plasma membrane, whereas the second is uniformly distributed in the cytoplasm. Recent work reported an analytical solution for the steady state gradient in this mechanism, obtained in the framework of a one-dimensional reaction-diffusion model. Here, we study the dynamics in this model and derive analytical expressions for the Laplace transforms of the time-dependent concentration profiles in terms of elementary transcendental functions. Inverting these transforms numerically, one can obtain time-dependent concentration profiles of the two forms of the protein. (C) 2015 AIP Publishing LLC.
C1 [Berezhkovskii, Alexander M.] Ctr Informat Technol, NIH, Div Computat Biosci, Math & Stat Comp Lab, Bethesda, MD 20892 USA.
   [Shvartsman, Stanislav Y.] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA.
   [Shvartsman, Stanislav Y.] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
RP Berezhkovskii, AM (reprint author), Ctr Informat Technol, NIH, Div Computat Biosci, Math & Stat Comp Lab, Bethesda, MD 20892 USA.
FU NIH, Center for Information Technology
FX A.M.B. was supported by the Intramural Research Program of the NIH,
   Center for Information Technology. S.Y.S. thanks Henry Mattingly for
   help with numerical inversion of Laplace transforms. S.Y.S. thanks David
   Odde and Erik Griffin for helpful discussions.
NR 7
TC 0
Z9 0
U1 0
U2 1
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD AUG 21
PY 2015
VL 143
IS 7
AR 074116
DI 10.1063/1.4928858
PG 6
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CQ2OJ
UT WOS:000360440400019
PM 26298124
ER

PT J
AU Simmonett, AC
   Pickard, FC
   Shao, YH
   Cheatham, TE
   Brooks, BR
AF Simmonett, Andrew C.
   Pickard, Frank C.
   Shao, Yihan
   Cheatham, Thomas E., III
   Brooks, Bernard R.
TI Efficient treatment of induced dipoles
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; PARTICLE-MESH EWALD; POLARIZABLE
   FORCE-FIELDS; BIOMOLECULAR SIMULATIONS; ELECTRONIC POLARIZATION;
   INTERACTION ENERGIES; ATOMIC INTERACTION; LARGE SYSTEMS; MODEL;
   ELECTROSTATICS
AB Most existing treatments of induced dipoles in polarizable molecular mechanics force field calculations use either the self-consistent variational method, which is solved iteratively, or the "direct" approximation that is non-iterative as a result of neglecting coupling between induced dipoles. The variational method is usually implemented using assumptions that are only strictly valid under tight convergence of the induced dipoles, which can be computationally demanding to enforce. In this work, we discuss the nature of the errors that result from insufficient convergence and suggest a strategy that avoids such problems. Using perturbation theory to reintroduce the mutual coupling into the direct algorithm, we present a computationally efficient method that combines the precision of the direct approach with the accuracy of the variational approach. By analyzing the convergence of this perturbation series, we derive a simple extrapolation formula that delivers a very accurate approximation to the infinite order solution at the cost of only a few iterations. We refer to the new method as extrapolated perturbation theory. Finally, we draw connections to our previously published permanent multipole algorithm to develop an efficient implementation of the electric field and Thole terms and also derive some necessary, but not sufficient, criteria that force field parameters must obey.
C1 [Simmonett, Andrew C.; Pickard, Frank C.; Shao, Yihan; Brooks, Bernard R.] NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA.
   [Shao, Yihan] Q Chem Inc, Pleasanton, CA 94588 USA.
   [Cheatham, Thomas E., III] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA.
RP Simmonett, AC (reprint author), NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA.
EM andrew.simmonett@nih.gov
OI Simmonett, Andrew/0000-0002-5921-9272; Pickard,
   Frank/0000-0002-9608-3466
FU National Heart, Lung and Blood Institute
FX This work was supported by the intramural research program of the
   National Heart, Lung and Blood Institute, and used resources of the
   Center for High Performance Computing at the University of Utah.
NR 57
TC 12
Z9 12
U1 6
U2 27
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD AUG 21
PY 2015
VL 143
IS 7
AR 074115
DI 10.1063/1.4928530
PG 12
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CQ2OJ
UT WOS:000360440400018
PM 26298123
ER

PT J
AU Kitamura, H
   Matsumori, H
   Kalendova, A
   Hozak, P
   Goldberg, IG
   Nakao, M
   Saitoh, N
   Harata, M
AF Kitamura, Hiroshi
   Matsumori, Haruka
   Kalendova, Alzbeta
   Hozak, Pavel
   Goldberg, Ilya G.
   Nakao, Mitsuyoshi
   Saitoh, Noriko
   Harata, Masahiko
TI The actin family protein ARP6 contributes to the structure and the
   function of the nucleolus
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Actin-related protein; ARP6; Histone H2A.Z; Nucleolus; Wndchrm
ID NUCLEAR-ORGANIZATION; RIBOSOME BIOGENESIS; HISTONE VARIANT;
   IMAGE-ANALYSIS; H2A.Z; TRANSCRIPTION; CHROMATIN; P53; HOMEOSTASIS;
   INTERACTS
AB The actin family members, consisting of actin and actin-related proteins (ARPs), are essential components of chromatin remodeling complexes. ARP6, one of the nuclear ARPs, is part of the Snf-2-related CREB-binding protein activator protein (SRCAP) chromatin remodeling complex, which promotes the deposition of the histone variant H2A.Z into the chromatin. In this study, we showed that ARP6 influences the structure and the function of the nucleolus. ARP6 is localized in the central region of the nucleolus, and its knockdown induced a morphological change in the nucleolus. We also found that in the presence of high concentrations of glucose ARP6 contributed to the maintenance of active ribosomal DNA (rDNA) transcription by placing H2A.Z into the chromatin. In contrast, under starvation, ARP6 was required for cell survival through the repression of rDNA transcription independently of H2A.Z. These findings reveal novel pleiotropic roles for the actin family in nuclear organization and metabolic homeostasis. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Kitamura, Hiroshi; Harata, Masahiko] Tohoku Univ, Grad Sch Agr Sci, Mol Biol Lab, Aoka Ku, Sendai, Miyagi 9818555, Japan.
   [Matsumori, Haruka; Nakao, Mitsuyoshi; Saitoh, Noriko] Kumamoto Univ, Inst Mol Embryol & Genet, Dept Med Cell Biol, Chuo Ku, Kumamoto 8600811, Japan.
   [Kalendova, Alzbeta; Hozak, Pavel] Acad Sci Czech Republic, Inst Mol Genet, Dept Biol Cell Nucleus, Vvi, CR-14220 Prague, Czech Republic.
   [Goldberg, Ilya G.] NIA, Image Informat & Computat Biol Unit, Genet Lab, NIH, Baltimore, MD 21224 USA.
   [Nakao, Mitsuyoshi] Japan Sci & Technol Agcy, CREST, Tokyo 1020076, Japan.
RP Harata, M (reprint author), Tohoku Univ, Grad Sch Agr Sci, Mol Biol Lab, Aoka Ku, Tsutsumidori Amamiyamachi 1-1, Sendai, Miyagi 9818555, Japan.
EM mharata@biochem.tohoku.ac.jp
RI Goldberg, Ilya/H-5307-2011
OI Goldberg, Ilya/0000-0001-8514-6110
FU Human Frontier Science Program [RGP0017]; Japan Society for the
   Promotion of Science (JSPS); Human Frontier in Science programe
   [RGP0017/2013]; Ministry of Education, Youth and Sports of the Czech
   Republic [CZ.1.07/2.3.00/30.0050]; project "BIOCEV - Biotechnology and
   Biomedicine Centre of the Academy of Sciences and Charles University"
   [CZ.1.05/1.1.00/02.0109]; European Regional Development Fund; Intramural
   Research Program of the U.S. National Institutes of Health, National
   Institute on Aging;  [25116009]
FX We thank all the members of the laboratory for the discussions. This
   work was supported by Grants-in-Aid for Scientific Research on
   Innovative Areas (25116009) (M.H. and N.S.) and the Human Frontier
   Science Program (RGP0017) (M.H.). H. K. and H. M. thank the Japan
   Society for the Promotion of Science (JSPS) for Young Scientist
   Fellowships.; P. H. was supported by Human Frontier in Science programe
   (RGP0017/2013), A. K. by Ministry of Education, Youth and Sports of the
   Czech Republic (CZ.1.07/2.3.00/30.0050). This publication is supported
   by the project "BIOCEV - Biotechnology and Biomedicine Centre of the
   Academy of Sciences and Charles University" (CZ.1.05/1.1.00/02.0109),
   from the European Regional Development Fund and with institutional
   support (RVO68378050).; IGG is supported by the Intramural Research
   Program of the U.S. National Institutes of Health, National Institute on
   Aging.
NR 36
TC 1
Z9 1
U1 1
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 21
PY 2015
VL 464
IS 2
BP 554
EP 560
DI 10.1016/j.bbrc.2015.07.005
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CO9RS
UT WOS:000359514000030
PM 26164235
ER

PT J
AU Guven-Maiorov, E
   Keskin, O
   Gursoy, A
   VanWaes, C
   Chen, Z
   Tsai, CJ
   Nussinov, R
AF Guven-Maiorov, Emine
   Keskin, Ozlem
   Gursoy, Attila
   VanWaes, Carter
   Chen, Zhong
   Tsai, Chung-Jung
   Nussinov, Ruth
TI The Architecture of the TIR Domain Signalosome in the Toll-like
   Receptor-4 Signaling Pathway
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NF-KAPPA-B; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL BASIS; ADAPTER
   RECRUITMENT; CRYSTAL-STRUCTURE; MOLECULAR-BASIS; CANCER; MYD88; TRAF3;
   INFLAMMATION
AB Activated Toll-like receptors (TLRs) cluster in lipid rafts and induce pro-and anti-tumor responses. The organization of the assembly is critical to the understanding of how these key receptors control major signaling pathways in the cell. Although several models for individual interactions were proposed, the entire TIR-domain signalosome architecture has not been worked out, possibly due to its complexity. We employ a powerful algorithm, crystal structures and experimental data to model the TLR4 and its cluster. The architecture that we obtain with 8 MyD88 molecules provides the structural basis for the MyD88-templated myddosome helical assembly and receptor clustering; it also provides clues to pro-and anti-inflammatory signaling pathways branching at the signalosome level to Mal/MyD88 and TRAM/TRIF pro-and anti-inflammatory pathways. The assembly of MyD88 death domain (DD) with TRAF3 (anti-viral/anti-inflammatory) and TRAF6 (pro-inflammatory) suggest that TRAF3/TRAF6 binding sites on MyD88 DD partially overlap, as do IRAK4 and FADD. Significantly, the organization illuminates mechanisms of oncogenic mutations, demonstrates that almost all TLR4 parallel pathways are competitive and clarifies decisions at pathway branching points. The architectures are compatible with the currently-available experimental data and provide compelling insights into signaling in cancer and inflammation pathways.
C1 [Guven-Maiorov, Emine; Keskin, Ozlem] Koc Univ, Dept Chem & Biol Engn, Istanbul, Turkey.
   [Guven-Maiorov, Emine; Keskin, Ozlem; Gursoy, Attila] Koc Univ, Ctr Computat Biol & Bioinformat, Istanbul, Turkey.
   [Gursoy, Attila] Koc Univ, Dept Comp Engn, Istanbul, Turkey.
   [VanWaes, Carter; Chen, Zhong] NIDCD, Clin Genom Unit, Head & Neck Surg Branch, NIH, Bethesda, MD 20892 USA.
   [Tsai, Chung-Jung; Nussinov, Ruth] NCI, Canc & Inflammat Program, Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
   [Nussinov, Ruth] Tel Aviv Univ, Sackler Sch Med, Dept Human Genet & Mol Med, Sackler Inst Mol Med, IL-69978 Tel Aviv, Israel.
RP Gursoy, A (reprint author), Koc Univ, Ctr Computat Biol & Bioinformat, Istanbul, Turkey.
EM agursoy@ku.edu.tr; nussinor@helix.nih.gov
RI Gursoy, Attila/E-9565-2015; 
OI Gursoy, Attila/0000-0002-2297-2113; Guven Maiorov,
   Emine/0000-0002-7388-9811
FU TUBITAK projects [114M196 and 113E164]; Frederick National Laboratory
   for Cancer Research, National Institutes of Health [HHSN261200800001E];
   Intramural Research Program of NIH, Frederick National Lab, Center for
   Cancer Research; Intramural Research Program of the NIH, National Cancer
   Institute, Center for Cancer Research
FX We acknowledge the funds from TUBITAK projects (in part) (Project No:
   114M196 and 113E164). OK and AG are the members of Science Academy,
   Turkey. This project has been funded in whole or in part with Federal
   funds from the Frederick National Laboratory for Cancer Research,
   National Institutes of Health, under contract HHSN261200800001E. This
   research was supported (in part) by the Intramural Research Program of
   NIH, Frederick National Lab, Center for Cancer Research. The content of
   this publication does not necessarily reflect the views or policies of
   the Department of Health and Human Services, nor does mention of trade
   names, commercial products, or organizations imply endorsement by the
   U.S. Government. This research was supported (in part) by the Intramural
   Research Program of the NIH, National Cancer Institute, Center for
   Cancer Research.
NR 60
TC 7
Z9 7
U1 0
U2 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 21
PY 2015
VL 5
AR 13128
DI 10.1038/srep13128
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP4HE
UT WOS:000359841800001
PM 26293885
ER

PT J
AU Zhou, BR
   Jiang, JS
   Feng, HQ
   Ghirlando, R
   Xiao, TS
   Bai, YW
AF Zhou, Bing-Rui
   Jiang, Jiansheng
   Feng, Hanqiao
   Ghirlando, Rodolfo
   Xiao, T. Sam
   Bai, Yawen
TI Structural Mechanisms of Nucleosome Recognition by Linker Histones
SO MOLECULAR CELL
LA English
DT Article
ID C-TERMINAL DOMAIN; NUCLEAR-MAGNETIC-RESONANCE; CHROMATIN IN-VIVO;
   DNA-BINDING SITES; GLOBULAR DOMAIN; INTERACTION SURFACE;
   CRYSTAL-STRUCTURE; CORE PARTICLE; H1 BINDING; H5
AB Linker histones bind to the nucleosome and regulate the structure of chromatin and gene expression. Despite more than three decades of effort, the structural basis of nucleosome recognition by linker histones remains elusive. Here, we report the crystal structure of the globular domain of chicken linker histone H5 in complex with the nucleosome at 3.5 angstrom resolution, which is validated using nuclear magnetic resonance spectroscopy. The globular domain sits on the dyad of the nucleosome and interacts with both DNA linkers. Our structure integrates results from mutation analyses and previous cross-linking and fluorescence recovery after photobleach experiments, and it helps resolve the long debate on structural mechanisms of nucleosome recognition by linker histones. The on-dyad binding mode of the H5 globular domain is different from the recently reported off-dyad binding mode of Drosophila linker histone H1. We demonstrate that linker histones with different binding modes could fold chromatin to form distinct higher-order structures.
C1 [Zhou, Bing-Rui; Feng, Hanqiao; Bai, Yawen] NCI, Lab Biochem & Mol Biol, NIH, Bethesda, MD 20892 USA.
   [Jiang, Jiansheng; Xiao, T. Sam] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   [Ghirlando, Rodolfo] NIDDK, Lab Mol Biol, NIH, Bethesda, MD 20892 USA.
RP Bai, YW (reprint author), NCI, Lab Biochem & Mol Biol, NIH, Bethesda, MD 20892 USA.
EM yawen@helix.nih.gov
FU National Cancer Institute; National Institute of Allergy and Infectious
   Diseases; National Institute of Diabetes and Digestive and Kidney
   Diseases National Cancer Institute [Y1-CO-1020]; National Institute of
   General Medical Sciences [Y1-GM-1104]; US Department of Energy
   [DE-AC02-06CH11357]
FX We thank Mr. S. Li for protein and DNA purification; the staff at the
   Advanced Photon Source (APS) (23-ID beamline) for technical support; T.
   Richmond and J. Hayes for DNA and H1.0 plasmids; G. Li and P. Zhu for
   coordinates of cryo-EM structural model; W. Yang, D. Xia., R. Wang, and
   F. Wang for discussion; C. Wu, A. Kelly, C. Klee, and G. Felsenfeld for
   commenting on the manuscript; and J. Barrowman for manuscript editing.
   This work is supported by the intramural programs of the National Cancer
   Institute (B.-R.Z., H.F., and Y.B.), the National Institute of Allergy
   and Infectious Diseases (J.J. and T.S.X.), the National Institute of
   Diabetes and Digestive and Kidney Diseases (R. G.) National Cancer
   Institute grant Y1-CO-1020, National Institute of General Medical
   Sciences grant Y1-GM-1104, and US Department of Energy grant
   DE-AC02-06CH11357 (APS).
NR 55
TC 36
Z9 37
U1 2
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
EI 1097-4164
J9 MOL CELL
JI Mol. Cell
PD AUG 20
PY 2015
VL 59
IS 4
BP 628
EP 638
DI 10.1016/j.molcel.2015.06.025
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CT0BE
UT WOS:000362457900013
PM 26212454
ER

PT J
AU Montgomery, DC
   Sorum, AW
   Guasch, L
   Nicklaus, MC
   Meier, JL
AF Montgomery, David C.
   Sorum, Alexander W.
   Guasch, Laura
   Nicklaus, Marc C.
   Meier, Jordan L.
TI Metabolic Regulation of Histone Acetyltransferases by Endogenous
   Acyl-CoA Cofactors
SO CHEMISTRY & BIOLOGY
LA English
DT Article
ID COENZYME-A; ACETYL-COA; RAT-LIVER; PROTEIN ACETYLATION; KINETIC
   MECHANISM; INHIBITORS; ENZYMES; GCN5; ESTERS; PROLIFERATION
AB The finding that chromatin modifications are sensitive to changes in cellular cofactor levels potentially links altered tumor cell metabolism and gene expression. However, the specific enzymes and metabolites that connect these two processes remain obscure. Characterizing these metabolic-epigenetic axes is critical to understanding how metabolism supports signaling in cancer, and developing therapeutic strategies to disrupt this process. Here, we describe a chemical approach to define the metabolic regulation of lysine acetyltransferase (KAT) enzymes. Using a novel chemoproteomic probe, we identify a previously unreported interaction between palmitoyl coenzyme A (palmitoyl-CoA) and KAT enzymes. Further analysis reveals that palmitoyl-CoA is a potent inhibitor of KAT activity and that fatty acyl-CoA precursors reduce cellular histone acetylation levels. These studies implicate fatty acyl-CoAs as endogenous regulators of histone acetylation, and suggest novel strategies for the investigation and metabolic modulation of epigenetic signaling.
C1 [Montgomery, David C.; Sorum, Alexander W.; Guasch, Laura; Nicklaus, Marc C.; Meier, Jordan L.] NCI, Biol Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA.
RP Meier, JL (reprint author), NCI, Biol Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA.
EM jordan.meier@nih.gov
RI Meier, Jordan/N-2608-2014; 
OI Nicklaus, Marc/0000-0002-4775-7030
FU NIH, National Cancer Institute, Center for Cancer Research [ZIA
   BC011488-02]
FX The authors thank Dr. Ming Zhou (Laboratory of Proteomics and Analytical
   Technology) for LC-MS/MS analyses and Dr. Carissa Grose (Protein
   Expression Laboratory) for assisting with cloning and preparation of
   plasmid DNA. Cellular extracts were prepared from HeLa cells grown by
   the National Cell Culture Center (NCCC, Minneapolis, MN). This work was
   supported by the Intramural Research Program of the NIH, National Cancer
   Institute, Center for Cancer Research (ZIA BC011488-02).
NR 50
TC 11
Z9 11
U1 4
U2 21
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-5521
EI 1879-1301
J9 CHEM BIOL
JI Chem. Biol.
PD AUG 20
PY 2015
VL 22
IS 8
BP 1030
EP 1039
DI 10.1016/j.chembiol.2015.06.015
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CS2DY
UT WOS:000361879200009
PM 26190825
ER

PT J
AU O'Sullivan, CC
   Bradbury, I
   Campbell, C
   Spielmann, M
   Perez, EA
   Joensuu, H
   Costantino, JP
   Delaloge, S
   Rastogi, P
   Zardavas, D
   Ballman, KV
   Holmes, E
   de Azambuja, E
   Piccart-Gebhart, M
   Zujewski, JA
   Gelber, RD
AF O'Sullivan, Ciara C.
   Bradbury, Ian
   Campbell, Christine
   Spielmann, Marc
   Perez, Edith A.
   Joensuu, Heikki
   Costantino, Joseph P.
   Delaloge, Suzette
   Rastogi, Priya
   Zardavas, Dimitrios
   Ballman, Karla V.
   Holmes, Eileen
   de Azambuja, Evandro
   Piccart-Gebhart, Martine
   Zujewski, Jo Anne
   Gelber, Richard D.
TI Efficacy of Adjuvant Trastuzumab for Patients With Human Epidermal
   Growth Factor Receptor 2-Positive Early Breast Cancer and Tumors <= 2
   cm: A Meta-Analysis of the Randomized Trastuzumab Trials
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID PLUS TRASTUZUMAB; OPEN-LABEL; PERTUZUMAB; DOCETAXEL; WOMEN; EXPRESSION;
   PACLITAXEL; LAPATINIB; OUTCOMES; SAFETY
AB Purpose
   We compared efficacy of trastuzumab versus no trastuzumab in patients with small (<= 2 cm) human epidermal growth factor receptor 2 (HER2) -positive breast cancer treated in randomized trials.
   Methods
   A meta-analysis was conducted using data from five of the six adjuvant trastuzumab trials. Efficacy end points were disease-free survival (DFS) and overall survival (OS). Separate analyses were prospectively planned for hormone receptor (HR) -positive and HR-negative cohorts. Random effect models and Yusuf-Peto fixed effects models assessed the impact of heterogeneity on baseline hazards and treatment effects across studies. Peto-Pike cumulative incidence estimates were stratified by study and nodal status.
   Results
   Median follow-up time was 8 years. For 2,263 patients with HR-positive disease, 8-year cumulative incidence rates comparing trastuzumab versus no trastuzumab were 17.3% versus 24.3% (P < .001) for DFS and 7.8% versus 11.6% (P = .005) for OS, respectively; for 1,092 HR-positive patients with zero or one positive lymph nodes, results were 12.7% versus 19.4% (P = .005) for DFS and 5.3% versus 7.4% (P = .12) for OS, respectively. For 1,957 patients with HR-negative disease, 8-year cumulative incidence rates were 24.0% versus 33.4% (P < .001) for DFS and 12.4% versus 21.2% (P < .001) for OS, respectively; for 1,040 HR-negative patients with zero or one positive lymph nodes, results were 20.4% versus 26.3% (P = .05) for DFS and 8.2% versus 12.2% (P = .084) for OS, respectively.
   Conclusion
   Women with HER2-positive tumors <= 2 cm in the randomized trastuzumab trials derived substantial DFS and OS benefit from adjuvant trastuzumab. Trastuzumab-treated patients with HR-positive disease and <= one positive lymph node may be candidates for trials assessing less aggressive treatment approaches. (C) 2015 by American Society of Clinical Oncology
C1 [O'Sullivan, Ciara C.; Zujewski, Jo Anne] NCI, Bethesda, MD 20892 USA.
   [Campbell, Christine; Holmes, Eileen] Frontier Sci, Kingussie, Inverness, Scotland.
   [Spielmann, Marc; Delaloge, Suzette] Inst Cancerol Gustave Roussy, Villejuif, France.
   [Perez, Edith A.] Mayo Clin, Jacksonville, FL 32224 USA.
   [Joensuu, Heikki] Helsinki Univ Hosp, Helsinki, Finland.
   [Joensuu, Heikki] Univ Helsinki, Helsinki, Finland.
   [Costantino, Joseph P.; Rastogi, Priya] Univ Pittsburgh, Pittsburgh, PA USA.
   [Zardavas, Dimitrios] Breast Int Grp, Rochester, MN USA.
   [Ballman, Karla V.] Mayo Clin, Rochester, MN USA.
   [de Azambuja, Evandro; Piccart-Gebhart, Martine] Inst Jules Bordet, B-1000 Brussels, Belgium.
   [de Azambuja, Evandro; Piccart-Gebhart, Martine] Univ Libre Bruxelles, Brussels, Belgium.
   [Gelber, Richard D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
   [Gelber, Richard D.] Frontier Sci & Technol Res Fdn Inc, Boston, MA USA.
RP O'Sullivan, CC (reprint author), NCI, Room 12N226,10 Ctr Dr, Bethesda, MD 20892 USA.
EM ciara.o'sullivan@nih.gov
FU NCI NIH HHS [P30 CA015083, U10 CA180844]
NR 36
TC 14
Z9 14
U1 0
U2 4
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 20
PY 2015
VL 33
IS 24
BP 2600
EP U37
DI 10.1200/JCO.2015.60.8620
PG 11
WC Oncology
SC Oncology
GA CR9EB
UT WOS:000361655000007
PM 26101239
ER

PT J
AU Ciprotti, M
   Tebbutt, NC
   Lee, FT
   Lee, ST
   Gan, HK
   McKee, DC
   O'Keefe, GJ
   Gong, SJ
   Chong, G
   Hopkins, W
   Chappell, B
   Scott, FE
   Brechbiel, MW
   Tse, AN
   Jansen, M
   Matsumura, M
   Kotsuma, M
   Watanabe, R
   Venhaus, R
   Beckman, RA
   Greenberg, J
   Scott, AM
AF Ciprotti, Marika
   Tebbutt, Niall C.
   Lee, Fook-Thean
   Lee, Sze-Ting
   Gan, Hui K.
   McKee, David C.
   O'Keefe, Graeme J.
   Gong, Sylvia J.
   Chong, Geoffrey
   Hopkins, Wendie
   Chappell, Bridget
   Scott, Fiona E.
   Brechbiel, Martin W.
   Tse, Archie N.
   Jansen, Mendel
   Matsumura, Manabu
   Kotsuma, Masakatsu
   Watanabe, Rira
   Venhaus, Ralph
   Beckman, Robert A.
   Greenberg, Jonathan
   Scott, Andrew M.
TI Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With
   Metastatic Colorectal Cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID DEATH RECEPTOR 5; PLACEBO-CONTROLLED PHASE-2; HUMAN MONOCLONAL-ANTIBODY;
   TRAIL-INDUCED APOPTOSIS; ADVANCED SOLID TUMORS; CELL LUNG-CANCER;
   1ST-LINE TREATMENT; ATTENUATION CORRECTION; TIGATUZUMAB CS-1008;
   PANCREATIC-CANCER
AB Purpose
   CS-1008 (tigatuzumab) is a humanized, monoclonal immunoglobulin G1 (IgG1) agonistic antibody to human death receptor 5. The purpose of this study was to investigate the impact of CS-1008 dose on the biodistribution, quantitative tumor uptake, and antitumor response in patients with metastatic colorectal cancer (mCRC).
   Patients and Methods
   Patients with mCRC who had received at least one course of chemotherapy were assigned to one of five dosage cohorts and infused with a weekly dose of CS-1008. Day 1 and day 36 doses were trace-labeled with indium-111 (In-111), followed by whole-body planar and regional single-photon emission computed tomography (SPECT) imaging at several time points over the course of 10 days.
   Results
   Nineteen patients were enrolled. In-111-CS-1008 uptake in tumor was observed in only 12 patients (63%). In-111-CS-1008 uptake and pharmacokinetics were not affected by dose or repeated drug administration. In-111-CS-1008 biodistribution showed gradual blood-pool clearance and no abnormal uptake in normal tissue. No anti-CS-1008 antibody development was detected. One patient achieved partial response (3.7 months duration), eight patients had stable disease, and 10 patients had progressive disease. Clinical benefit rate (stable disease + partial response) in patients with In-111-CS-1008 uptake in tumor was 58% versus 28% in patients with no uptake. An analysis of individual lesions showed that lesions with antibody uptake were one third as likely to progress as those without antibody uptake (P = .07). Death-receptor-5 expression in archived tumor samples did not correlate with In-111-CS-1008 uptake (P = .5) or tumor response (P = .6).
   Conclusion
   Death-receptor-5 imaging with In-111-CS-1008 reveals interpatient and intrapatient heterogeneity of uptake in tumor, is not dose dependent, and is predictive of clinical benefit in the treatment of patients who have mCRC. (C) 2015 by American Society of Clinical Oncology
C1 [Ciprotti, Marika; Tebbutt, Niall C.; Lee, Fook-Thean; Lee, Sze-Ting; Gan, Hui K.; Hopkins, Wendie; Scott, Fiona E.; Scott, Andrew M.] Ludwig Inst Canc Res, Melbourne, Vic 3050, Australia.
   [McKee, David C.; O'Keefe, Graeme J.; Gong, Sylvia J.; Chong, Geoffrey; Chappell, Bridget; Scott, Andrew M.] Austin Hlth, Melbourne, Vic, Australia.
   [Brechbiel, Martin W.] NCI, Bethesda, MD 20892 USA.
   [Tse, Archie N.; Greenberg, Jonathan] Daiichi Sankyo Co Ltd, Parsippany, NJ USA.
   [Jansen, Mendel] Daiichi Sankyo Dev Ltd, Gerrards Cross, Bucks, England.
   [Matsumura, Manabu; Kotsuma, Masakatsu; Watanabe, Rira] Daiichi Sankyo Co Ltd, Tokyo, Japan.
   [Beckman, Robert A.] Georgetown Univ Med Ctr, New York, NY USA.
   [Venhaus, Ralph] Ludwig Inst Canc Res, New York, NY USA.
RP Scott, AM (reprint author), Austin Hosp, Olivia Newton John Canc Res Inst, Level 5 ONJCWC,145 Studley Rd, Heidelberg, Vic 3084, Australia.
EM andrew.scott@onjcri.org.au
RI Scott, Fiona/K-8106-2013
FU Daiichi Sankyo Co., Ltd.
FX Supported by Daiichi Sankyo Co., Ltd.
NR 43
TC 5
Z9 5
U1 0
U2 4
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 20
PY 2015
VL 33
IS 24
BP 2609
EP U49
DI 10.1200/JCO.2014.60.4256
PG 12
WC Oncology
SC Oncology
GA CR9EB
UT WOS:000361655000008
PM 26124477
ER

PT J
AU Robinson, GW
   Orr, BA
   Wu, G
   Gururangan, S
   Lin, T
   Qaddoumi, I
   Packer, RJ
   Goldman, S
   Prados, MD
   Desjardins, A
   Chintagumpala, M
   Takebe, N
   Kaste, SC
   Rusch, M
   Allen, SJ
   Onar-Thomas, A
   Stewart, CF
   Fouladi, M
   Boyett, JM
   Gilbertson, RJ
   Curran, T
   Ellison, DW
   Gajjar, A
AF Robinson, Giles W.
   Orr, Brent A.
   Wu, Gang
   Gururangan, Sridharan
   Lin, Tong
   Qaddoumi, Ibrahim
   Packer, Roger J.
   Goldman, Stewart
   Prados, Michael D.
   Desjardins, Annick
   Chintagumpala, Murali
   Takebe, Naoko
   Kaste, Sue C.
   Rusch, Michael
   Allen, Sariah J.
   Onar-Thomas, Arzu
   Stewart, Clinton F.
   Fouladi, Maryam
   Boyett, James M.
   Gilbertson, Richard J.
   Curran, Tom
   Ellison, David W.
   Gajjar, Amar
TI Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic
   Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain
   Tumor Consortium Studies PBTC-025B and PBTC-032
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID PATHWAY INHIBITOR; TP53 MUTATIONS; SUPPRESSOR; RESISTANCE; CHILDREN;
   MICE
AB Purpose
   Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB).
   Patients and Methods
   Adult patients enrolled onto PBTC-025B and pediatric patients enrolled onto PBTC-032 were treated with vismodegib (150 to 300 mg/d). Protocol-defined response, which had to be sustained for 8 weeks, was confirmed by central neuroimaging review. Molecular tests to identify patterns of response and insensitivity were performed when tissue was available.
   Results
   A total of 31 patients were enrolled onto PBTC-025B, and 12 were enrolled onto PBTC-032. Three patients in PBTC-025B and one in PBTC-032, all with SHH-subgroup MB (SHH-MB), exhibited protocol-defined responses. Progression-free survival (PFS) was longer in those with SHH-MB than in those with non-SHH-MB, and prolonged disease stabilization occurred in 41% of patient cases of SHH-MB. Among those with SHH-MB, loss of heterozygosity of PTCH1 was associated with prolonged PFS, and diffuse staining of P53 was associated with reduced PFS. Whole-exome sequencing identified mutations in SHH genes downstream from SMO in four of four tissue samples from nonresponders and upstream of SMO in two of four patients with favorable responses.
   Conclusion
   Vismodegib exhibits activity against adult recurrent SHH-MB but not against recurrent non-SHH-MB. Inadequate accrual of pediatric patients precluded conclusions in this population. Molecular analyses support the hypothesis that SMO inhibitor activity depends on the genomic aberrations within the tumor. Such inhibitors should be advanced in SHH-MB studies; however, molecular and genomic work remains imperative to identify target populations that will truly benefit. (C) 2015 by American Society of Clinical Oncology
C1 [Robinson, Giles W.; Orr, Brent A.; Wu, Gang; Lin, Tong; Qaddoumi, Ibrahim; Kaste, Sue C.; Rusch, Michael; Allen, Sariah J.; Onar-Thomas, Arzu; Stewart, Clinton F.; Boyett, James M.; Gilbertson, Richard J.; Ellison, David W.; Gajjar, Amar] St Jude Childrens Res Hosp, Memphis, TN 38104 USA.
   [Gururangan, Sridharan; Desjardins, Annick] Duke Univ, Med Ctr, Durham, NC USA.
   [Packer, Roger J.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
   [Goldman, Stewart] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA.
   [Prados, Michael D.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Chintagumpala, Murali] Texas Childrens Canc Ctr, Houston, TX USA.
   [Takebe, Naoko] NCI, Bethesda, MD 20892 USA.
   [Fouladi, Maryam] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Curran, Tom] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
RP Robinson, GW (reprint author), St Jude Childrens Res Hosp, Dept Oncol, MS 260,262 Danny Thomas Pl, Memphis, TN 38104 USA.
EM giles.robinson@stjude.org
RI Curran, Tom/D-7515-2011
FU National Institutes of Health [U01 CA81457]; Cancer Center Core [CA
   21765]; Noyes Brain Tumor Foundation; Musicians Against Childhood
   Cancer; American Lebanese Syrian Associated Charities
FX Supported in part by National Institutes of Health Grant No. U01 CA81457
   to the Pediatric Brain Tumor Consortium, Cancer Center Core Grant No. CA
   21765, the Noyes Brain Tumor Foundation, Musicians Against Childhood
   Cancer, and the American Lebanese Syrian Associated Charities.
NR 33
TC 31
Z9 31
U1 2
U2 11
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 20
PY 2015
VL 33
IS 24
BP 2646
EP U106
DI 10.1200/JCO.2014.60.1591
PG 16
WC Oncology
SC Oncology
GA CR9EB
UT WOS:000361655000013
PM 26169613
ER

PT J
AU Kent, EE
   Mitchell, SA
   Castro, KM
   DeWalt, DA
   Kaluzny, AD
   Hautala, JA
   Grad, O
   Ballard, RM
   McCaskill-Stevens, WJ
   Kramer, BS
   Clauser, SB
AF Kent, Erin E.
   Mitchell, Sandra A.
   Castro, Kathleen M.
   DeWalt, Darren A.
   Kaluzny, Arnold D.
   Hautala, Judith A.
   Grad, Oren
   Ballard, Rachel M.
   McCaskill-Stevens, Worta J.
   Kramer, Barnett S.
   Clauser, Steven B.
TI Cancer Care Delivery Research: Building the Evidence Base to Support
   Practice Change in Community Oncology
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID COLONY-STIMULATING FACTORS; PREVENTIVE SERVICE DELIVERY; RANDOMIZED
   CONTROLLED-TRIAL; BREAST-CONSERVING SURGERY; CLINICAL ONCOLOGY; AMERICAN
   SOCIETY; COLORECTAL-CANCER; CONSENSUS GUIDELINE; FOLLOW-UP; IMPROVEMENT
AB Understanding how health care system structures, processes, and available resources facilitate and/or hinder the delivery of quality cancer care is imperative, especially given the rapidly changing health care landscape. The emerging field of cancer care delivery research (CCDR) focuses on how organizational structures and processes, care delivery models, financing and reimbursement, health technologies, and health care provider and patient knowledge, attitudes, and behaviors influence cancer care quality, cost, and access and ultimately the health outcomes and well-being of patients and survivors. In this article, we describe attributes of CCDR, present examples of studies that illustrate those attributes, and discuss the potential impact of CCDR in addressing disparities in care. We conclude by emphasizing the need for collaborative research that links academic and community-based settings and serves simultaneously to accelerate the translation of CCDR results into practice. The National Cancer Institute recently launched its Community Oncology Research Program, which includes a focus on this area of research. (C) 2015 by American Society of Clinical Oncology
C1 [Kent, Erin E.; Mitchell, Sandra A.; Castro, Kathleen M.; McCaskill-Stevens, Worta J.; Kramer, Barnett S.; Clauser, Steven B.] NCI, NIH, Bethesda, MD 20892 USA.
   [Ballard, Rachel M.] NIH, Off Dis Prevent, Bethesda, MD 20892 USA.
   [DeWalt, Darren A.; Kaluzny, Arnold D.] Univ N Carolina, Chapel Hill, NC USA.
   [Hautala, Judith A.; Grad, Oren] Inst Def Anal Sci & Technol Policy Inst, Alexandria, VA USA.
RP Mitchell, SA (reprint author), 9609 Med Ctr Dr, Rockville, MD 20850 USA.
EM mitchlls@mail.nih.gov
OI DeWalt, Darren/0000-0003-2270-751X
NR 52
TC 9
Z9 9
U1 1
U2 2
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 20
PY 2015
VL 33
IS 24
BP 2705
EP U183
DI 10.1200/JCO.2014.60.6210
PG 9
WC Oncology
SC Oncology
GA CR9EB
UT WOS:000361655000021
PM 26195715
ER

PT J
AU Ciurea, SO
   Zhang, MJ
   Bacigalupo, AA
   Bashey, A
   Appelbaum, FR
   Aljitawi, OS
   Armand, P
   Antin, JH
   Chen, JF
   Devine, SM
   Fowler, DH
   Luznik, L
   Nakamura, R
   O'Donnell, PV
   Perales, MA
   Pingali, SR
   Porter, DL
   Riches, MR
   Ringden, OTH
   Rocha, V
   Vij, R
   Weisdorf, DJ
   Champlin, RE
   Horowitz, MM
   Fuchs, EJ
   Eapen, M
AF Ciurea, Stefan O.
   Zhang, Mei-Jie
   Bacigalupo, Andrea A.
   Bashey, Asad
   Appelbaum, Frederick R.
   Aljitawi, Omar S.
   Armand, Philippe
   Antin, Joseph H.
   Chen, Junfang
   Devine, Steven M.
   Fowler, Daniel H.
   Luznik, Leo
   Nakamura, Ryotaro
   O'Donnell, Paul V.
   Perales, Miguel-Angel
   Pingali, Sai Ravi
   Porter, David L.
   Riches, Marcie R.
   Ringden, Olle T. H.
   Rocha, Vanderson
   Vij, Ravi
   Weisdorf, Daniel J.
   Champlin, Richard E.
   Horowitz, Mary M.
   Fuchs, Ephraim J.
   Eapen, Mary
TI Haploidentical transplant with posttransplant cyclophosphamide vs
   matched unrelated donor transplant for acute myeloid leukemia
SO BLOOD
LA English
DT Article
ID STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION;
   HLA-MISMATCHED/HAPLOIDENTICAL BLOOD; RISK HEMATOLOGIC MALIGNANCIES;
   GRAFT FAILURE; INTERNATIONAL BLOOD; COMPLETE REMISSION; OUTCOMES;
   ADULTS; FLUDARABINE
AB We studied adults with acute myeloid leukemia (AML) after haploidentical (n = 192) and 8/8 HLA-matched unrelated donor (n = 1982) transplantation. Haploidentical recipients received calcineurin inhibitor (CNI), mycophenolate, and posttransplant cyclophosphamide for graft-versus-host disease (GVHD) prophylaxis; 104 patients received myeloablative and 88 received reduced intensity conditioning regimens. Matched unrelated donor transplant recipients received CNI with mycophenolate or methotrexate for GVHD prophylaxis; 1245 patients received myeloablative and 737 received reduced intensity conditioning regimens. In the myeloablative setting, day 30 neutrophil recovery was lower after haploidentical compared with matched unrelated donor transplants (90% vs 97%, P = .02). Corresponding rates after reduced intensity conditioning transplants were 93% and 96% (P = .25). In the myeloablative setting, 3-month acute grade 2-4 (16% vs 33%, P < .0001) and 3-year chronic GVHD (30% vs 53%, P < .0001) were lower after haploidentical compared with matched unrelated donor transplants. Similar differences were observed after reduced intensity conditioning transplants, 19% vs 28% (P = .05) and 34% vs 52% (P = .002). Among patients receiving myeloablative regimens, 3-year probabilities of overall survival were 45% (95% CI, 36-54) and 50% (95% CI, 47-53) after haploidentical and matched unrelated donor transplants (P5.38). Corresponding rates after reduced intensity conditioning transplants were 46%(95% CI, 35-56) and 44% (95% CI, 0.40-47) (P = .71). Although statistical poweris limited, these data suggests that survival for patients with AML after haploidentical transplantation with posttransplant cyclophosphamide is comparable with matched unrelated donor transplantation.
C1 [Ciurea, Stefan O.; Pingali, Sai Ravi; Champlin, Richard E.] Univ Texas MD Anderson Canc Ctr, Dept Med, Houston, TX 77030 USA.
   [Zhang, Mei-Jie; Chen, Junfang; Horowitz, Mary M.; Eapen, Mary] Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
   [Zhang, Mei-Jie] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
   [Bacigalupo, Andrea A.] IRCCS Azienda Osped Univ AOU San Martino IST, Dept Hematol, Genoa, Italy.
   [Bashey, Asad] Northside Hosp, Dept Med, Atlanta, GA USA.
   [Appelbaum, Frederick R.; O'Donnell, Paul V.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
   [Aljitawi, Omar S.] Univ Kansas, Med Ctr, Dept Med, Kansas City, KS 66103 USA.
   [Armand, Philippe; Antin, Joseph H.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.
   [Devine, Steven M.] Ohio State Univ, Dept Internal Med, Arthur C James Canc Hosp, Ctr Comprehens Canc, Columbus, OH 43210 USA.
   [Fowler, Daniel H.] NCI, Expt Transplantat & Immunobiol, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA.
   [Luznik, Leo; Fuchs, Ephraim J.] Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Dept Med Hematol, Baltimore, MD USA.
   [Nakamura, Ryotaro] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA.
   [Perales, Miguel-Angel] Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, New York, NY 10021 USA.
   [Porter, David L.] Univ Penn, Abramson Canc Ctr, Hematol Oncol, Philadelphia, PA 19104 USA.
   [Riches, Marcie R.] H Lee Moffitt Canc Ctr & Res Inst, Dept Med, Tampa, FL USA.
   [Ringden, Olle T. H.] Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
   [Rocha, Vanderson] Churchill Hosp, Oxford OX3 7LJ, England.
   [Vij, Ravi] Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.
   [Weisdorf, Daniel J.] Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
RP Ciurea, SO (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, 1515 Holcombe Blvd,Unit 423, Houston, TX 77030 USA.
EM sciurea@mdanderson.org
FU National Institutes of Health National Cancer Institute, National Heart,
   Lung, and Blood Institute [U24-CA076518]; National Heart, Lung, and
   Blood Institute [5U10HL069294]; National Cancer Institute; Health
   Resources and Services Administration [HHSH250201200016C]; Office of
   Naval Research [N00014-13-1-0039, N00014-14-1-0028]; Actinium
   Pharmaceuticals; Allos Therapeutics, Inc.; Amgen, Inc.; Shield
   Association; Celgene Corporation; Chimerix, Inc.; Fred Hutchinson Cancer
   Research Center; Fresenius Biotech North America, Inc.; Gamida Cell Teva
   Joint Venture Ltd.; Genentech, Inc.; Gentium SpA; Genzyme Corporation;
   GlaxoSmithKline; Health Research, Inc.; Roswell Park Cancer Institute;
   HistoGenetics, Inc.; Incyte Corporation; Jeff Gordon Children's
   Foundation; Kiadis Pharma; Medac GmbH; Medical College of Wisconsin;
   MerckCo,Inc.; Millennium: The Takeda Oncology Co.; Milliman USA, Inc.;
   Miltenyi Biotec, Inc.; National Marrow Donor Program; Onyx
   Pharmaceuticals; Optum Healthcare Solutions, Inc.; Osiris Therapeutics,
   Inc.; Otsuka America Pharmaceutical, Inc.; PerkinElmer, Inc.; Remedy
   Informatics; Sanofi US; Seattle Genetics; Sigma-Tau Pharmaceuticals;
   Soligenix, Inc.; St. Baldrick's Foundation; StemCyte; Stemsoft Software,
   Inc.; Swedish Orphan Biovitrum; Tarix Pharmaceuticals; TerumoBCT; Teva
   Neuroscience, Inc.; THERAKOS, Inc.; University of Minnesota; University
   of Utah; Wellpoint, Inc.
FX The CIBMTR is supported by a Public Health Service grant/cooperative
   agreement (U24-CA076518) from the National Institutes of Health National
   Cancer Institute, the National Heart, Lung, and Blood Institute, and the
   National Institute of Allergy and Infectious Diseases; a
   grant/cooperative agreement from the National Heart, Lung, and Blood
   Institute (5U10HL069294) and National Cancer Institute; a contract with
   Health Resources and Services Administration (HHSH250201200016C); grants
   from the Office of Naval Research (N00014-13-1-0039 and
   N00014-14-1-0028); and grants from the following: Actinium
   Pharmaceuticals; Allos Therapeutics, Inc.; Amgen, Inc.; anonymous
   donation to the Medical College of Wisconsin; Ariad; Be the Match
   Foundation; Blue Cross and Blue Shield Association; Celgene Corporation;
   Chimerix, Inc.; Fred Hutchinson Cancer Research Center; Fresenius
   Biotech North America, Inc.; Gamida Cell Teva Joint Venture Ltd.;
   Genentech, Inc.; Gentium SpA; Genzyme Corporation; GlaxoSmithKline;
   Health Research, Inc., Roswell Park Cancer Institute; HistoGenetics,
   Inc.; Incyte Corporation; Jeff Gordon Children's Foundation; Kiadis
   Pharma; Medac GmbH; The Medical College of Wisconsin; Merck & Co,Inc.;
   Millennium: The Takeda Oncology Co.; Milliman USA, Inc.; Miltenyi
   Biotec, Inc.; National Marrow Donor Program; Onyx Pharmaceuticals; Optum
   Healthcare Solutions, Inc.; Osiris Therapeutics, Inc.; Otsuka America
   Pharmaceutical, Inc.; PerkinElmer, Inc.; Remedy Informatics; Sanofi US;
   Seattle Genetics; Sigma-Tau Pharmaceuticals; Soligenix, Inc.; St.
   Baldrick's Foundation; StemCyte; Stemsoft Software, Inc.; Swedish Orphan
   Biovitrum; Tarix Pharmaceuticals; TerumoBCT; Teva Neuroscience, Inc.;
   THERAKOS, Inc.; University of Minnesota; University of Utah; and
   Wellpoint, Inc. The views expressed in this article do not reflect the
   official policy or position of the National Institutes of Health, the
   Department of the Navy, the Department of Defense, Health Resources and
   Services Administration, or any other agency of the US government.
NR 36
TC 71
Z9 74
U1 0
U2 3
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD AUG 20
PY 2015
VL 126
IS 8
BP 1033
EP 1040
DI 10.1182/blood-2015-04-639831
PG 8
WC Hematology
SC Hematology
GA CQ3WU
UT WOS:000360535700023
PM 26130705
ER

PT J
AU Riestra, P
   Gebreab, SY
   Xu, RH
   Khan, RJ
   Bidulescu, A
   Correa, A
   Tekola-Ayele, F
   Davis, SK
AF Riestra, Pia
   Gebreab, Samson Y.
   Xu, Ruihua
   Khan, Rumana J.
   Bidulescu, Aurelian
   Correa, Adolfo
   Tekola-Ayele, Fasil
   Davis, Sharon K.
TI Gender-specific associations between ADIPOQ gene polymorphisms and
   adiponectin levels and obesity in the Jackson Heart Study cohort
SO BMC MEDICAL GENETICS
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; GENOME-WIDE ASSOCIATION; PLASMA
   ADIPONECTIN; AFRICAN-AMERICANS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PROMOTER VARIANTS; IRAS FAMILY; RISK; ATHEROSCLEROSIS
AB Background: Despite the important role of adiponectin in regulating general metabolic homeostasis, analysis of genetic determinants of adiponectin and the related cardio-metabolic traits in African American population has been limited and inconsistent.
   Considering the high genetic admixture of African Americans and thus the important population stratification that may confound the genetic-trait associations, the objective of this work was to perform a comprehensive analysis of the associations between ADIPOQ variants and adiponectin levels and obesity phenotypes in a large African American population from the Jackson Heart Study (JHS) cohort.
   Methods: Genotype data was available for 2968 JHS participants (1131men; 1837women). Single Nucleotide Polymorphisms (SNPs) were selected by a Tag-SNP Approach and literature review. The genotype imputation was performed using IMPUTE2 software and reference phased data from the 1000G project. PLINK software was used for the genetic analysis. Plasma specimens were analyzed by ELISA for adiponectin levels. All analyses were controlled for population stratification assessed by Individual Proportions of European Ancestry (PEA) estimates calculated in HAPMIX using ancestry informative markers (AIMs).
   Results: We found a gender-dependent association of some ADIPOQ variants and adiponectin levels. In women four of the studied polymorphisms (rs6444174, rs16861205, rs1403697, rs7641507) were associated with adiponectin levels after Bonferroni correction and controlling for the percentage of PEA, age, annual household income and smoking. These results were consistent with the haplotype analysis. The association between the rs12495941 variant and obesity is modulated by the PEA, so that the relationship between the G allele and a higher incidence of obesity was present in those individuals within the lower PEA group. In addition we found an effect modification of obesity on the association between the ADIPOQ rs6444174 SNP and BMI so that the presence of the T allele was negatively and significantly associated with BMI only in participants with a normal weight.
   Conclusions: In this large African American cohort, ADIPOQ variants were associated with adiponectin levels in a gender-dependent manner and the relationship of some of these variants with obesity and BMI was modulated by the PEA and obesity status respectively. This suggests that the effects of these polymorphisms on adiponectin and obesity phenotypes are subject to a strong interaction with genetic and environmental factors in African American population.
C1 [Riestra, Pia; Gebreab, Samson Y.; Xu, Ruihua; Khan, Rumana J.; Davis, Sharon K.] NHGRI, Genom Metab Cardiovasc & Inflammatory Dis Branch, Social Epidemiol Res Unit, NIH, Bethesda, MD 20892 USA.
   [Bidulescu, Aurelian] Indiana Univ, Sch Publ Hlth, Bloomington, IN 47405 USA.
   [Correa, Adolfo] Jackson Heart Study, Jackson, MS 39217 USA.
   [Tekola-Ayele, Fasil] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA.
RP Riestra, P (reprint author), NHGRI, Genom Metab Cardiovasc & Inflammatory Dis Branch, Social Epidemiol Res Unit, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM Teresa.riestra@nih.gov
OI Tekola-Ayele, Fasil/0000-0003-4194-9370
FU National Heart, Lung, and Blood Institute [HHSN268201300046C,
   HHSN268201300047C, HHSN268201300048C, HHSN268201300049C,
   HHSN268201300050C]; National Institute on Minority Health and Health
   Disparities; PHS from the National Institutes of Health, National Center
   for Research Resources [UL1 RR025008]; NIH, National Heart, Lung and
   Blood Institute [UH1 HL073461]; intramural program of the National Human
   Genome Research Institute, National Institutes of Health
FX The Jackson Heart Study is supported by contracts HHSN268201300046C,
   HHSN268201300047C, HHSN268201300048C, HHSN268201300049C,
   HHSN268201300050C from the National Heart, Lung, and Blood Institute and
   the National Institute on Minority Health and Health Disparities.; The
   adiponectin measurements were partially supported by PHS Award UL1
   RR025008 from the National Institutes of Health, National Center for
   Research Resources and by the NIH grant UH1 HL073461 provided by the
   National Heart, Lung and Blood Institute.; Pia Riestra, Sharon K Davis,
   Samson Gebreab, Ruihua Xu, Rumana Khan and Fasil Tekola-Ayele are
   supported by the intramural program of the National Human Genome
   Research Institute, National Institutes of Health.
NR 58
TC 7
Z9 7
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD AUG 20
PY 2015
VL 16
AR 65
DI 10.1186/s12881-015-0214-x
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA CP7GW
UT WOS:000360056200001
PM 26290432
ER

PT J
AU Liao, CY
   Selvan, ME
   Zhao, J
   Slimovitch, JL
   Schneebeli, ST
   Shelley, M
   Shelley, JC
   Li, JN
AF Liao, Chenyi
   Selvan, Myvizhi Esai
   Zhao, Jun
   Slimovitch, Jonathan L.
   Schneebeli, Severin T.
   Shelley, Mee
   Shelley, John C.
   Li, Jianing
TI Melittin Aggregation in Aqueous Solutions: Insight from Molecular
   Dynamics Simulations
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID HIGH-RESOLUTION H-1-NMR; CIRCULAR-DICHROISM; SECONDARY STRUCTURE;
   MONOMERIC MELITTIN; SELF-ASSOCIATION; LIPID-BILAYERS; MEMBRANES;
   TETRAMER; BINDING; LYSIS
AB Melittin is a natural peptide that aggregates in aqueous solutions with paradigmatic monomer-to-tetramer and coil-to-helix transitions. Since little is known about the molecular mechanisms of melittin aggregation in solution, we simulated its self-aggregation process under various conditions. After confirming the stability of a melittin tetramer in solution, we observed-for the first time in atomistic detail that four separated melittin monomers aggregate into a tetramer. Our simulated dependence of melittin aggregation on peptide concentration, temperature, and ionic strength is in good agreement with prior experiments. We propose that melittin mainly self-aggregates via a mechanism involving the sequential addition of monomers, which is supported by both qualitative and quantitative evidence obtained from unbiased and metadynainics simulations. Moreover, by combining computer simulations and a theory of the electrical double layer, we provide evidence to suggest why melittin aggregation in solution likely stops at the tetramer, rather than forming higher-order oligomers. Overall, our study not only explains prior experimental results at the molecular level but also provides quantitative mechanistic information that may guide the engineering of melittin for higher efficacy and safety.
C1 [Liao, Chenyi; Slimovitch, Jonathan L.; Schneebeli, Severin T.; Li, Jianing] Univ Vermont, Dept Chem, Burlington, VT 05405 USA.
   [Selvan, Myvizhi Esai] Schrodinger Inc, New York, NY 10036 USA.
   [Zhao, Jun] NIDCD, Bethesda, MD 20892 USA.
   [Shelley, Mee; Shelley, John C.] Schrodinger Inc, Portland, OR 97204 USA.
RP Li, JN (reprint author), Univ Vermont, Dept Chem, Burlington, VT 05405 USA.
EM jianing.li@uvm.edu
FU National Science Foundation [ACI-1053575]
FX This work used computational resources provided by Vermont Advanced
   Computing Core (VACC), as well as Black light from the Extreme Science
   and Engineering Discovery Environment (XSEDE) supported by National
   Science Foundation Grant No. ACI-1053575.
NR 48
TC 1
Z9 1
U1 4
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD AUG 20
PY 2015
VL 119
IS 33
BP 10390
EP 10398
DI 10.1021/acs.jpcb.5b03254
PG 9
WC Chemistry, Physical
SC Chemistry
GA CP6VN
UT WOS:000360026400002
PM 26208115
ER

PT J
AU Qi, RX
   Luo, Y
   Wei, GH
   Nussinov, R
   Ma, BY
AF Qi, Ruxi
   Luo, Yin
   Wei, Guanghong
   Nussinov, Ruth
   Ma, Buyong
TI A beta "Stretching-and-Packing" Cross-Seeding Mechanism Can Trigger Tau
   Protein Aggregation
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; DOCK-LOCK MECHANISM; AMYLOID-BETA;
   ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASES; FIBRIL ELONGATION;
   TRANSGENIC MICE; MOUSE-BRAIN; PATHOLOGY; OLIGOMERS
AB There are synergistic effects of A beta and tau protein in Alzheimer's disease. A beta(1-42) protofibril seeds induce conversion of human tau protein into beta-sheet-rich toxic tau oligomers. However, the molecular mechanisms underlying such a conformational conversion are unclear. Here, we use extensive all atom replica exchange molecular dynamics simulations to investigate the effects of preformed A beta(1-42) protofibril on two monomeric tau constructs: K18 and K19. We found that A beta oligomer stretches tau conformation and drastically reduces the metastable secondary structures/hydrogen bonding/salt-bridge networks in tau monomers and exposes their fibril nucleating motifs (275)VQIINK(280) and (306)VQIVYK(311). A beta interacting patches around Tyr10/Ile41 contribute significantly to the interactions with K18 and K19. A beta cross-seeded tau aggregation can adopt a "stretching-and-packing" mechanism, paving the way for the next, prion-like growth step. The results provide a mechanism on the atomic level to experimental observations that tau pathogenesis is promoted by A beta(1-42) but not by A beta(1-40).
C1 [Qi, Ruxi; Luo, Yin; Wei, Guanghong] Fudan Univ, State Key Lab Surface Phys, Key Lab Computat Phys Sci MOE, Shanghai 200433, Peoples R China.
   [Qi, Ruxi; Luo, Yin; Wei, Guanghong] Fudan Univ, Dept Phys, Shanghai 200433, Peoples R China.
   [Nussinov, Ruth; Ma, Buyong] NCI, Leidos Biomed Res Inc, Basic Sci Program, Canc & Inflammat Program, Frederick, MD 21702 USA.
   [Nussinov, Ruth] Tel Aviv Univ, Sackler Inst Mol Med, Dept Human Genet & Mol Med, Sadder Sch Med, IL-69978 Tel Aviv, Israel.
RP Wei, GH (reprint author), Fudan Univ, State Key Lab Surface Phys, Key Lab Computat Phys Sci MOE, Shanghai 200433, Peoples R China.
EM ghwei@fudan.edu.cn; mabuyong@mail.nih.gov
RI Ma, Buyong/F-9491-2011
OI Ma, Buyong/0000-0002-7383-719X
FU NSF of China [91227102, 11274075]; NCI, NIH [HHSN261200800001E]; NIH,
   National Cancer Institute, Center for Cancer Research
FX G.W. acknowledges the financial support from the NSF of China (Grant
   No.: 91227102 and 11274075). RN. and B.M. thank the financial support
   from NCI, NIH, under contract number HHSN261200800001E. This research
   was supported (in part) by the Intramural Research Program of the NIH,
   National Cancer Institute, Center for Cancer Research. Simulations were
   performed at the NIH Biowulf supercomputer cluster.
NR 43
TC 7
Z9 7
U1 3
U2 33
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD AUG 20
PY 2015
VL 6
IS 16
BP 3276
EP 3282
DI 10.1021/acs.jpclett.5b01447
PG 7
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
   Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA CP6VT
UT WOS:000360027000016
ER

PT J
AU Goo, L
   Pierson, TC
AF Goo, Leslie
   Pierson, Theodore C.
TI DENGUE VIRUS Bumps in the road to therapeutic antibodies
SO NATURE
LA English
DT Editorial Material
ID NEUTRALIZING ANTIBODIES
C1 [Goo, Leslie; Pierson, Theodore C.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Goo, L (reprint author), NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
EM piersontc@mail.nih.gov
NR 15
TC 0
Z9 0
U1 1
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD AUG 20
PY 2015
VL 524
IS 7565
BP 295
EP 296
PG 3
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2NN
UT WOS:000359714000021
PM 26289200
ER

PT J
AU Lazarou, M
   Sliter, DA
   Kane, LA
   Sarraf, SA
   Wang, CX
   Burman, JL
   Sideris, DP
   Fogel, AI
   Youle, RJ
AF Lazarou, Michael
   Sliter, Danielle A.
   Kane, Lesley A.
   Sarraf, Shireen A.
   Wang, Chunxin
   Burman, Jonathon L.
   Sideris, Dionisia P.
   Fogel, Adam I.
   Youle, Richard J.
TI The ubiquitin kinase PINK1 recruits autophagy receptors to induce
   mitophagy
SO NATURE
LA English
DT Article
ID PARKIN-MEDIATED MITOPHAGY; OPEN-ANGLE GLAUCOMA; DEPOLARIZED
   MITOCHONDRIA; SELECTIVE AUTOPHAGY; ACTIVATE PARKIN; PHOSPHORYLATION;
   OPTINEURIN; P62/SQSTM1; COMPLEX; BINDING
AB Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains on mitochondrial outer membrane proteins, where they act to recruit autophagy receptors. Using genome editing to knockout five autophagy receptors in HeLa cells, here we show that two receptors previously linked to xenophagy, NDP52 and optineurin, are the primary receptors for PINK1- and parkin-mediated mitophagy. PINK1 recruits NDP52 and optineurin, but not p62, to mitochondria to activate mitophagy directly, independently of parkin. Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and WIPI1 to focal spots proximal to mitochondria, revealing a function for these autophagy receptors upstream of LC3. This supports a new model in which PINK1-generated phospho-ubiquitin serves as the autophagy signal on mitochondria, and parkin then acts to amplify this signal. This work also suggests direct and broader roles for ubiquitin phosphorylation in other autophagy pathways.
C1 [Lazarou, Michael; Sliter, Danielle A.; Kane, Lesley A.; Sarraf, Shireen A.; Wang, Chunxin; Burman, Jonathon L.; Sideris, Dionisia P.; Fogel, Adam I.; Youle, Richard J.] NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
RP Youle, RJ (reprint author), NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM youler@ninds.nih.gov
RI Wang, Chunxin/B-9312-2016; 
OI Wang, Chunxin/0000-0001-6015-6806; Lazarou, Michael/0000-0003-2150-5545
FU NIH, NINDS; National Health and Medical Research Council [GNT1063781]
FX We thank C. Nezich and S. Banerjee in the Youle laboratory, C. Smith and
   the NINDS and NHLBI Flow Cytometry Core Facilities. This work was
   supported by the Intramural Research Program of the NIH, NINDS and the
   National Health and Medical Research Council (GNT1063781).
NR 42
TC 177
Z9 179
U1 28
U2 95
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD AUG 20
PY 2015
VL 524
IS 7565
BP 309
EP +
DI 10.1038/nature14893
PG 22
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2NN
UT WOS:000359714000027
PM 26266977
ER

PT J
AU Ledgerwood, JE
   Sullivan, NJ
   Graham, BS
AF Ledgerwood, Julie E.
   Sullivan, Nancy J.
   Graham, Barney S.
TI Chimpanzee Adenovirus Vector Ebola Vaccine - Preliminary Report Reply
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Ledgerwood, Julie E.; Sullivan, Nancy J.; Graham, Barney S.] NIAID, Bethesda, MD 20892 USA.
RP Ledgerwood, JE (reprint author), NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM ledgerwood@mail.nih.gov
NR 4
TC 10
Z9 10
U1 0
U2 4
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD AUG 20
PY 2015
VL 373
IS 8
BP 776
EP 776
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CP2LU
UT WOS:000359709400021
PM 26287857
ER

PT J
AU Chien, YH
   Abdenur, JE
   Baronio, F
   Bannick, AA
   Corrales, F
   Couce, M
   Donner, MG
   Ficicioglu, C
   Freehauf, C
   Frithiof, D
   Gotway, G
   Hirabayashi, K
   Hofstede, F
   Hoganson, G
   Hwu, WL
   James, P
   Kim, S
   Korman, SH
   Lachmann, R
   Levy, H
   Lindner, M
   Lykopoulou, L
   Mayatepek, E
   Muntau, A
   Okano, Y
   Raymond, K
   Rubio-Gozalbo, E
   Scholl-Buergi, S
   Schulze, A
   Singh, R
   Stabler, S
   Stuy, M
   Thomas, J
   Wagner, C
   Wilson, WG
   Wortmann, S
   Yamamoto, S
   Pao, M
   Blom, HJ
AF Chien, Yin-Hsiu
   Abdenur, Jose E.
   Baronio, Federico
   Bannick, Allison Anne
   Corrales, Fernando
   Couce, Maria
   Donner, Markus G.
   Ficicioglu, Can
   Freehauf, Cynthia
   Frithiof, Deborah
   Gotway, Garrett
   Hirabayashi, Koichi
   Hofstede, Floris
   Hoganson, George
   Hwu, Wuh-Liang
   James, Philip
   Kim, Sook
   Korman, Stanley H.
   Lachmann, Robin
   Levy, Harvey
   Lindner, Martin
   Lykopoulou, Lilia
   Mayatepek, Ertan
   Muntau, Ania
   Okano, Yoshiyuki
   Raymond, Kimiyo
   Rubio-Gozalbo, Estela
   Scholl-Buergi, Sabine
   Schulze, Andreas
   Singh, Rani
   Stabler, Sally
   Stuy, Mary
   Thomas, Janet
   Wagner, Conrad
   Wilson, William G.
   Wortmann, Saskia
   Yamamoto, Shigenori
   Pao, Maryland
   Blom, Henk J.
TI Mudd's disease (MAT I/III deficiency): a survey of data for MAT1A
   homozygotes and compound heterozygotes
SO ORPHANET JOURNAL OF RARE DISEASES
LA English
DT Article
ID METHIONINE ADENOSYLTRANSFERASE-I/III; S-ADENOSYLMETHIONINE SYNTHETASE;
   PLASMA TOTAL HOMOCYSTEINE; BLOOD-BRAIN-BARRIER; CEREBROSPINAL-FLUID;
   PERSISTENT HYPERMETHIONINEMIA; DOMINANT INHERITANCE; MESSENGER-RNA;
   EXPRESSION; MUTATION
AB Background: This paper summarizes the results of a group effort to bring together the worldwide available data on patients who are either homozygotes or compound heterozygotes for mutations in MAT1A. MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). Subnormal MAT I/III activity leads to hypermethioninemia. Individuals, with hypermethioninemia due to one of the MAT1A mutations that in heterozygotes cause relatively mild and clinically benign hypermethioninemia are currently often being flagged in screening programs measuring methionine elevation to identify newborns with defective cystathionine beta-synthase activity. Homozygotes or compound heterozygotes for MAT1A mutations are less frequent. Some but not all, such individuals have manifested demyelination or other CNS abnormalities.
   Purpose of the study: The goals of the present effort have been to determine the frequency of such abnormalities, to find how best to predict whether they will occur, and to evaluate the outcomes of the variety of treatment regimens that have been used. Data have been gathered for 64 patients, of whom 32 have some evidence of CNS abnormalities (based mainly on MRI findings), and 32 do not have such evidence.
   Results and Discussion: The results show that mean plasma methionine concentrations provide the best indication of the group into which a given patient will fall: those with means of 800 mu M or higher usually have evidence of CNS abnormalities, whereas those with lower means usually do not. Data are reported for individual patients for MAT1A genotypes, plasma methionine, total homocysteine (tHcy), and AdoMet concentrations, liver function studies, results of 15 pregnancies, and the outcomes of dietary methionine restriction and/or AdoMet supplementation. Possible pathophysiological mechanisms that might contribute to CNS damage are discussed, and tentative suggestions are put forth as to optimal management.
C1 [Chien, Yin-Hsiu; Hwu, Wuh-Liang] Natl Taiwan Univ Hosp, Dept Med Genet & Pediat, Taipei, Taiwan.
   [Abdenur, Jose E.] CHOC Childrens, Div Metab Disorders, Orange, CA USA.
   [Baronio, Federico] Univ Bologna, Newborn Screening & Inborn Errors Metab Reg Ctr, Pediat Endocrinol Program, Pediat Unit,S Orsola Malpighi Hosp, Bologna, Italy.
   [Bannick, Allison Anne] Childrens Hosp Michigan Metab Clin, Detroit Med Ctr, Detroit, MI USA.
   [Corrales, Fernando] Univ Navarra, Ctr Appl Med Res CIMA, Dept Hepatol, Prote Lab,IdiSNA, E-31080 Pamplona, Spain.
   [Couce, Maria] Univ Santiago, Head Metab Unit, Dept Pediat, Hosp Clin, Santiago De Compostela, Spain.
   [Donner, Markus G.] Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Dusseldorf, Germany.
   [Ficicioglu, Can] Univ Penn, Childrens Hosp Philadelphia, Div Metab, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Freehauf, Cynthia; Thomas, Janet] Univ Colorado, Dept Pediat, Aurora, CO USA.
   [Frithiof, Deborah] Umea Univ, Dept Clin Sci Pediat, SE-90185 Umea, Sweden.
   [Gotway, Garrett] Univ Texas SW Med Ctr Dallas, Dept Pediat, Div Genet & Metab, Dept Internal Med,Div Clin Genet, Dallas, TX 75390 USA.
   [Gotway, Garrett] Univ Texas SW Med Ctr Dallas, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA.
   [Hirabayashi, Koichi] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 390, Japan.
   [Hofstede, Floris] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Div Paediat, Dept Metab Dis, Utrecht, Netherlands.
   [Hoganson, George] Univ Illinois, Coll Med, Dept Pediat, Chicago, IL USA.
   [James, Philip; Levy, Harvey] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA.
   [Kim, Sook] KSZ Childrens Hosp, Korea Genet Res Ctr, Cheng Ju City, Chung Buk, South Korea.
   [Korman, Stanley H.] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Genet, Jerusalem, Israel.
   [Korman, Stanley H.] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Metab Dis, Jerusalem, Israel.
   [Lachmann, Robin] Natl Hosp Neurol & Neurosurg, Charles Dent Metab Unit, London, England.
   [Lindner, Martin] Univ Heidelberg Hosp, Dept Gen Pediat, Div Pediat Metab Med & Neuropediat, Heidelberg, Germany.
   [Lindner, Martin] Univ Childrens Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.
   [Lykopoulou, Lilia] Univ Athens, Dept Pediat 1, Agia Sofia Childrens Hosp, Athens, Greece.
   [Mayatepek, Ertan] Univ Childrens Hosp Duesseldorf, Dept Gen Pediat Neonatol & Pediat Cardiol, Dusseldorf, Germany.
   [Muntau, Ania] Univ Med Ctr Hamburg Eppendorf, Univ Childrens Hosp, Hamburg, Germany.
   [Okano, Yoshiyuki] Hyogo Coll Med, Dept Genet, Nishinomiya, Hyogo 6638501, Japan.
   [Raymond, Kimiyo] Mayo Clin, Coll Med, Dept Med & Pathol, Biochem Genet Lab, Rochester, MN USA.
   [Rubio-Gozalbo, Estela] Maastricht Univ, Med Ctr, Dept Pediat, Maastricht, Netherlands.
   [Rubio-Gozalbo, Estela] Maastricht Univ, Med Ctr, Lab Genet Metab Dis, Maastricht, Netherlands.
   [Scholl-Buergi, Sabine] Med Univ Innsbruck, Clin Pediat Inherited Metab Disorders, Innsbruck, Austria.
   [Schulze, Andreas] Hosp Sick Children, Genet & Genome Biol, Peter Gilgan Ctr Res & Learning, Toronto, ON M5G 1X8, Canada.
   [Singh, Rani] Emory Univ, Dept Human Genet & Pediat, Atlanta, GA 30322 USA.
   [Stabler, Sally] Univ Colorado, Sch Med, Dept Med, Aurora, CO USA.
   [Stuy, Mary] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
   [Wagner, Conrad] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA.
   [Wilson, William G.] Univ Virginia, Sch Med, Div Genet, Charlottesville, VA 22908 USA.
   [Wortmann, Saskia] Amalia Childrens Hosp, Nijmegen Ctr Mitochondrial Disorders, RadboudUMC, Nijmegen, Netherlands.
   [Yamamoto, Shigenori] Natl Shimoshizu Hosp, Dept Pediat, Chiba, Japan.
   [Pao, Maryland] NIMH, Mol Biol Lab, Bethesda, MD 20892 USA.
   [Blom, Henk J.] Univ Hosp Freiburg, Lab Clin Biochem & Metab, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany.
RP Blom, HJ (reprint author), Univ Hosp Freiburg, Ctr Pediat & Adolescent Med, Lab Clin Biochem & Metab, D-79106 Freiburg, Germany.
EM henk.blom@uniklinik-freiburg.de
RI rubio, estela/H-1833-2011; BARONIO, FEDERICO/C-1468-2017; 
OI BARONIO, FEDERICO/0000-0003-3470-6880; HWU,
   WUH-LIANG/0000-0001-6690-4879; Ficicioglu, Can/0000-0002-8331-9804
FU National Institute of Mental Health Intramural Research Program; E-HOD
   project of the European Union [2012_12_02]
FX This research was supported in part by National Institute of Mental
   Health Intramural Research Program and the E-HOD project (No.
   2012_12_02) of the European Union in the framework of the Health
   Program. The opinions expressed in the article are the views of the
   authors and do not necessarily reflect the views of the Department of
   Health and Human Services or the United States government.
NR 82
TC 4
Z9 5
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1750-1172
J9 ORPHANET J RARE DIS
JI Orphanet J. Rare Dis.
PD AUG 20
PY 2015
VL 10
AR 99
DI 10.1186/s13023-015-0321-y
PG 21
WC Genetics & Heredity; Medicine, Research & Experimental
SC Genetics & Heredity; Research & Experimental Medicine
GA CP2UZ
UT WOS:000359734000002
PM 26289392
ER

PT J
AU Hiyoshi, M
   Okuma, K
   Tateyama, S
   Takizawa, K
   Saito, M
   Kuramitsu, M
   Araki, K
   Morishita, K
   Okada, S
   Yamamoto, N
   Biragyn, A
   Yamaguchi, K
   Hamaguchi, I
AF Hiyoshi, Masateru
   Okuma, Kazu
   Tateyama, Seiji
   Takizawa, Kazuya
   Saito, Masumichi
   Kuramitsu, Madoka
   Araki, Kumiko
   Morishita, Kazuhiro
   Okada, Seiji
   Yamamoto, Naoki
   Biragyn, Arya
   Yamaguchi, Kazunari
   Hamaguchi, Isao
TI Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection
   by targeting and eliminating infected CCR4-expressing cells in vitro and
   in vivo
SO RETROVIROLOGY
LA English
DT Article
DE HTLV-1; CCR4; CCL17/TARC; Pseudomonas exotoxin; Furin
ID VIRUS TYPE-I; PSEUDOMONAS EXOTOXIN-A; CHEMOKINE RECEPTOR 4;
   MACROPHAGE-DERIVED CHEMOKINE; MONOCLONAL-ANTIBODY KW-0761; REGULATORY
   T-CELLS; HEPATITIS-B-VIRUS; NF-KAPPA-B; LEUKEMIA-VIRUS; HEMATOLOGIC
   MALIGNANCIES
AB Background: Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express CCR4 frequently, we tested whether truncated Pseudomonas exotoxin (PE38) fused to a CCR4 ligand, CCL17/thymus and activation-regulated chemokine (TARC), selectively eliminates such cells.
   Results: Our data show that TARC-PE38 efficiently killed HTLV-1-infected cell lines. It also shrank HTLV-1-associated solid tumors in an infected-cell-engrafted mouse model. In HTLV-1-positive humanized mice, TARC-PE38 markedly inhibited the proliferation of HTLV-1-infected human CD4(+)CD25(+) or CD4(+)CD25(+)CCR4(+) cells and reduced the proviral loads (PVLs) in peripheral blood mononuclear cells (PBMCs). Importantly, TARC-PE38 significantly reduced the PVLs in PBMCs obtained from asymptomatic carriers. We show that the cytotoxicity of TARC-PE38 is mediated by the expression of the proprotein convertase, furin. The expression of furin was enhanced in HTLV-1-infected cells and correlated positively with PVLs in HTLV-1-infected individuals, suggesting that infected cells are more susceptible to TARC-PE38 than normal cells.
   Conclusions: TARC-PE38 robustly controls HTLV-1 infection by eliminating infected cells in both a CCR4- and furindependent manner, indicating the excellent therapeutic potential of TARC-PE38.
C1 [Hiyoshi, Masateru; Okuma, Kazu; Tateyama, Seiji; Takizawa, Kazuya; Saito, Masumichi; Kuramitsu, Madoka; Araki, Kumiko; Yamaguchi, Kazunari; Hamaguchi, Isao] Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo 2080011, Japan.
   [Tateyama, Seiji] Micron Inc, Med Facil Support Dept, Chiyoda Ku, Tokyo 1000005, Japan.
   [Morishita, Kazuhiro] Miyazaki Univ, Fac Med, Dept Med Sci, Div Tumor & Cellular Biochem, Kiyotake, Miyazaki 8891692, Japan.
   [Okada, Seiji] Kumamoto Univ, Ctr AIDS Res, Div Hematopoiesis, Kumamoto 8600811, Japan.
   [Yamamoto, Naoki] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Singapore 117599, Singapore.
   [Biragyn, Arya] NIA, Immunoregulat Sect, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA.
RP Okuma, K (reprint author), Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo 2080011, Japan.
EM kokuma@niid.go.jp; 130hama@niid.go.jp
FU Ministry of Health, Labour and Welfare of Japan [H23-sinkou-ippan-016];
   Japan Agency for Medical Research and Development, AMED; Japanese
   Society for the Promotion of Science (JSPS) [24591414, 15K09462,
   15K08439]
FX The authors thank N. Arima for providing the S1T cells, K. Sugamura for
   providing the TL-Om1 and JPX-9 cells, J. Fujisawa for providing the
   JET35 and JEX22 cells, and K. Hirose for helpful discussions. We also
   acknowledge the technical support by Y. Takahama and Y. Hamaguchi. This
   work was supported by a Health Labour Sciences Research Grant from the
   Ministry of Health, Labour and Welfare of Japan (Grant number
   H23-sinkou-ippan-016 to IH), Research Program on Emerging and
   Re-emerging Infectious Diseases from Japan Agency for Medical Research
   and Development, AMED to IH, and the Japanese Society for the Promotion
   of Science (JSPS) KAKENHI (grant number 24591414, 15K09462 to IH, and
   15K08439 to KO).
NR 64
TC 0
Z9 0
U1 2
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-4690
J9 RETROVIROLOGY
JI Retrovirology
PD AUG 20
PY 2015
VL 12
AR 73
DI 10.1186/s12977-015-0199-8
PG 14
WC Virology
SC Virology
GA CP2CT
UT WOS:000359685800001
PM 26289727
ER

PT J
AU Abeuova, LS
   Scholthof, HB
   Ramankulov, EM
   Manabayeva, SA
AF Abeuova, Laura S.
   Scholthof, Herman B.
   Ramankulov, Erlan M.
   Manabayeva, Shuga A.
TI Tomato bushy stunt virus-based vector for transient expression of human
   G-CSF in Nicotiana benthamiana plants
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Abeuova, Laura S.; Ramankulov, Erlan M.; Manabayeva, Shuga A.] Natl Ctr Biotechnol Republ Kazakhstan, Astana, Kazakhstan.
   [Scholthof, Herman B.] Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX 77843 USA.
EM manabayeva@biocenter.kz
NR 0
TC 0
Z9 0
U1 1
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S29
EP S29
DI 10.1016/j.jbiotec.2015.06.079
PG 1
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000079
ER

PT J
AU Ayupova, AZ
   Sarsenova, AS
   Sharipov, RS
   Yagofarova, AY
   Sharipova, GZ
   Moldagulova, NB
   Kurmanbayev, AA
AF Ayupova, A. Zh.
   Sarsenova, A. S.
   Sharipov, R. S.
   Yagofarova, A. Ya.
   Sharipova, G. Zn.
   Moldagulova, N. B.
   Kurmanbayev, A. A.
TI Screening of oil oxidizing microorganisms for bioremediation of
   contaminated ecosystems
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Ayupova, A. Zh.; Sarsenova, A. S.; Yagofarova, A. Ya.; Sharipova, G. Zn.; Moldagulova, N. B.; Kurmanbayev, A. A.] Natl Ctr Biotechnol SC MES RK, Lab Environm Biotechnol, Astana, Kazakhstan.
   [Sharipov, R. S.] Forens Ctr MU RK, Astana, Kazakhstan.
EM a.ibraeva@mail.ru
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S61
EP S61
DI 10.1016/j.jbiotec.2015.06.183
PG 1
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000183
ER

PT J
AU Kanayev, DB
   Moldagulova, NB
   Abdrashitov, AA
   Khassenova, EZ
   Silayev, DV
   Kurmanbayev, AA
AF Kanayev, Darkhan Babanovich
   Moldagulova, Nazira Baltabayevna
   Abdrashitov, Ardak Ardovich
   Khassenova, Elmira Zheksembayevna
   Silayev, Dmitriy Vitalyevich
   Kurmanbayev, Askar Abylaikhanovich
TI Utilization of sewage sludge with native microflora
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Kanayev, Darkhan Babanovich; Moldagulova, Nazira Baltabayevna; Abdrashitov, Ardak Ardovich; Khassenova, Elmira Zheksembayevna; Silayev, Dmitriy Vitalyevich; Kurmanbayev, Askar Abylaikhanovich] Natl Biotechnol Ctr, Astana, Kazakhstan.
EM dake_2008z@mail.ru
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S61
EP +
DI 10.1016/j.jbiotec.2015.06.184
PG 2
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000184
ER

PT J
AU Khassenova, E
   Kurmanbayev, A
   Makhatova, A
   Abdrashitov, A
   Yagofarova, A
   Moldagulova, N
AF Khassenova, Elmira
   Kurmanbayev, Askar
   Makhatova, Aigerim
   Abdrashitov, Ardak
   Yagofarova, Almira
   Moldagulova, Nazira
TI Biodegradation of oil hydrocarbons with psychrophilic strain
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Khassenova, Elmira; Kurmanbayev, Askar; Makhatova, Aigerim; Abdrashitov, Ardak; Yagofarova, Almira; Moldagulova, Nazira] Natl Biotechnol Ctr, Astana, Kazakhstan.
EM elmira_alta@mail.ru
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S62
EP +
DI 10.1016/j.jbiotec.2015.06.187
PG 2
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000187
ER

PT J
AU Makenova, AT
   Scholthof, HB
   Ramankulov, EM
   Manabayeva, SA
AF Makenova, Aiganym T.
   Scholthof, Herman B.
   Ramankulov, Erlan M.
   Manabayeva, Shuga A.
TI Transient expression of Acidothermus cellulolyticus endoglucanase E1 by
   a Tomato bushy stunt virus-based plant expression vector
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Makenova, Aiganym T.; Ramankulov, Erlan M.; Manabayeva, Shuga A.] Natl Biotechnol Ctr, Astana, Kazakhstan.
   [Scholthof, Herman B.] Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX 77843 USA.
EM manabayeva@biocenter.kz
NR 0
TC 0
Z9 0
U1 2
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S29
EP +
DI 10.1016/j.jbiotec.2015.06.080
PG 2
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000080
ER

PT J
AU Turganbayeva, A
   Kakimzhanova, A
   Sheck, G
AF Turganbayeva, Assiya
   Kakimzhanova, Almagul
   Sheck, Galina
TI Evaluation of regenerated lines of wheat for drought tolerance
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Turganbayeva, Assiya; Kakimzhanova, Almagul; Sheck, Galina] Natl Biotechnol Ctr, Astana, Kazakhstan.
EM ass.turg@gmail.com
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S30
EP S30
DI 10.1016/j.jbiotec.2015.06.082
PG 1
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000082
ER

PT J
AU Yessimseitova, A
   Ahmetollaev, I
   Shustov, A
   Krassavin, V
   Kochieva, E
   Zhanybekova, Z
   Kakimzhanova, A
AF Yessimseitova, Assel
   Ahmetollaev, Ilyas
   Shustov, Alexander
   Krassavin, Valery
   Kochieva, Elena
   Zhanybekova, Zhanargul
   Kakimzhanova, Almagul
TI Molecular identification of potato varieties on the basis of DNA
   technology
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Meeting Abstract
CT European Biotechnology Congress
CY MAY 07-09, 2015
CL Bucharest, ROMANIA
C1 [Yessimseitova, Assel; Ahmetollaev, Ilyas; Shustov, Alexander; Zhanybekova, Zhanargul; Kakimzhanova, Almagul] Natl Biotechnol Ctr, Astana, Kazakhstan.
   [Krassavin, Valery] Kazakh Res Inst Potato & Vegetable, Almaty Oblast, Almaty Region, Kazakhstan.
   [Kochieva, Elena] Ctr Bioengn, Moscow, Russia.
EM kakimzhanova@mail.ru
NR 0
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD AUG 20
PY 2015
VL 208
SU S
BP S30
EP +
DI 10.1016/j.jbiotec.2015.06.083
PG 2
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CO3UW
UT WOS:000359087000083
ER

PT J
AU Ceko, M
   Gracely, JL
   Fitzcharles, MA
   Seminowicz, DA
   Schweinhardt, P
   Bushnell, MC
AF Ceko, Marta
   Gracely, John L.
   Fitzcharles, Mary-Ann
   Seminowicz, David A.
   Schweinhardt, Petra
   Bushnell, M. Catherine
TI Is a Responsive Default Mode Network Required for Successful Working
   Memory Task Performance?
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE chronic pain; default mode; external-task-positive; FMRI; task
   performance; working memory
ID N-BACK TASK; PREFRONTAL CORTEX; BRAIN NETWORKS; CHRONIC PAIN; FUNCTIONAL
   CONNECTIVITY; NEUROIMAGING DATA; FMRI; ACTIVATION; COGNITION; ATTENTION
AB In studies of cognitive processing using tasks with externally directed attention, regions showing increased (external-task-positive) and decreased or "negative" [default-mode network (DMN)] fMRI responses during task performance are dynamically responsive to increasing task difficulty. Responsiveness (modulation of fMRI signal by increasing load) has been linked directly to successful cognitive task performance in external-task-positive regions but not in DMN regions. To investigate whether a responsive DMN is required for successful cognitive performance, we compared healthy human subjects (n = 23) with individuals shown to have decreased DMN engagement (chronic pain patients, n = 28). Subjects performed a multilevel working-memory task (N-back) during fMRI. If a responsive DMN is required for successful performance, patients having reduced DMN responsiveness should show worsened performance; if performance is not reduced, their brains should show compensatory activation in external-task-positive regions or elsewhere. All subjects showed decreased accuracy and increased reaction times with increasing task level, with no significant group differences on either measure at any level. Patients had significantly reduced negative fMRI response (deactivation) of DMN regions (posterior cingulate/precuneus, medial prefrontal cortex). Controls showed expected modulation of DMN deactivation with increasing task difficulty. Patients showed significantly reduced modulation of DMN deactivation by task difficulty, despite their successful task performance. We found no evidence of compensatory neural recruitment in external-task-positive regions or elsewhere. Individual responsiveness of the external-task-positive ventrolateral prefrontal cortex, but not of DMN regions, correlated with task accuracy. These findings suggest that a responsive DMN may not be required for successful cognitive performance; a responsive external-task-positive network may be sufficient.
C1 [Ceko, Marta; Gracely, John L.; Bushnell, M. Catherine] NIH, Natl Ctr Complementary & Integrat Hlth, Bethesda, MD 20892 USA.
   [Schweinhardt, Petra] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ H3A 0G4, Canada.
   [Schweinhardt, Petra] McGill Univ, Dent, Montreal, PQ H3A 0G4, Canada.
   [Schweinhardt, Petra] McGill Univ, Neurol & Neurosurg, Montreal, PQ H3A 0G4, Canada.
   [Fitzcharles, Mary-Ann] McGill Univ, Rheumatol, Montreal, PQ H3A 0G4, Canada.
   [Seminowicz, David A.] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA.
RP Bushnell, MC (reprint author), Bldg 35A,Room 1D822,35A Convent Dr, Bethesda, MD 20892 USA.
EM mary.bushnell@nih.gov
FU Intramural Research Program of the National Institutes of Health,
   National Center for Complementary and Integrative Health; American
   Fibromyalgia Syndrome Association
FX This research was supported in part by the Intramural Research Program
   of the National Institutes of Health, National Center for Complementary
   and Integrative Health. We thank the team at the McConnell Brain Imaging
   Centre of the Montreal Neurological Institute for expert MRI data
   acquisition. We also acknowledge the American Fibromyalgia Syndrome
   Association for financial support. We thank Valerie Cotton, Marissa
   Lapedis, and Carl Frechette for subject recruitment. Finally, we thank
   the anonymous reviewers whose constructive comments improved this
   manuscript.
NR 53
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Z9 6
U1 3
U2 12
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 19
PY 2015
VL 35
IS 33
BP 11595
EP 11605
DI 10.1523/JNEUROSCI.0264-15.2015
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CT0PW
UT WOS:000362499700011
PM 26290236
ER

PT J
AU Sewal, AS
   Patzke, H
   Perez, EJ
   Park, P
   Lehrmann, E
   Zhang, YQ
   Becker, KG
   Fletcher, BR
   Long, JM
   Rapp, PR
AF Sewal, Angila S.
   Patzke, Holger
   Perez, Evelyn J.
   Park, Pul
   Lehrmann, Elin
   Zhang, Yongqing
   Becker, Kevin G.
   Fletcher, Bonnie R.
   Long, Jeffrey M.
   Rapp, Peter R.
TI Experience Modulates the Effects of Histone Deacetylase Inhibitors on
   Gene and Protein Expression in the Hippocampus: Impaired Plasticity in
   Aging
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE cognitive aging; epigenetics; histone acetylation; microarray; synaptic
   protein
ID LONG-TERM-MEMORY; FACILITATES FEAR EXTINCTION; SYNAPTIC PLASTICITY; HDAC
   INHIBITION; COGNITIVE DECLINE; RAT HIPPOCAMPUS; ACETYLATION;
   TRANSCRIPTION; MODEL; MICE
AB The therapeutic potential of histone deacetylase inhibitor (HDACi) treatment has attracted considerable attention in the emerging area of cognitive neuroepigenetics. The possibility that ongoing cognitive experience importantly regulates the cell biological effects of HDACi administration, however, has not been systematically examined. In an initial experiment addressing this issue, we tested whether water maze training influences the gene expression response to acute systemic HDACi administration in the young adult rat hippocampus. Training powerfully modulated the response to HDACi treatment, increasing the total number of genes regulated to nearly 3000, including many not typically linked to neural plasticity, compared with <300 following HDACi administration alone. Although water maze training itself also regulated nearly 1800 genes, the specific mRNAs, gene networks, and biological pathways involved were largely distinct when the same experience was provided together with HDACi administration. Next, we tested whether the synaptic protein response to HDACi treatment is similarly dependent on recent cognitive experience, and whether this plasticity is altered in aged rats with memory impairment. Whereas synaptic protein labeling in the young hippocampus was selectively increased when HDACi administration was provided in conjunction with water maze training, combined treatment had no effect on synaptic proteins in the aged hippocampus. Our findings indicate that ongoing experience potently regulates the molecular consequences of HDACi treatment and that the interaction of recent cognitive experience with histone acetylation dynamics is disrupted in the aged hippocampus.
C1 [Sewal, Angila S.; Perez, Evelyn J.; Park, Pul; Fletcher, Bonnie R.; Long, Jeffrey M.; Rapp, Peter R.] NIA, Neurocognit Aging Sect, Baltimore, MD 21224 USA.
   [Sewal, Angila S.] Icahn Sch Med Mt Sinai, Grad Program Neurosci, New York, NY 10029 USA.
   [Patzke, Holger] FORUM Pharmaceut, Waltham, MA 02451 USA.
   [Lehrmann, Elin; Zhang, Yongqing; Becker, Kevin G.] NIA, Gene Express & Genom Unit, Baltimore, MD 21224 USA.
RP Rapp, PR (reprint author), NIA, Lab Behav Neurosci, 251 Bayview Blvd,Suite 100, Baltimore, MD 21224 USA.
EM rappp@mail.nih.gov
FU Intramural Research Program of the National Institute on Aging
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging. We thank Mia Tarley for early discussions
   on experimental design, Wafae Driwech for technical assistance on the
   synaptic protein quantification, Rebecca Haberman for discussions on
   microarray data analytic strategies, and members of the Neurocognitive
   Aging Section for helpful discussions.
NR 55
TC 7
Z9 8
U1 0
U2 6
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 19
PY 2015
VL 35
IS 33
BP 11729
EP 11742
DI 10.1523/JNEUROSCI.4339-14.2015
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA CT0PW
UT WOS:000362499700024
PM 26290249
ER

PT J
AU Jang, AI
   Costa, VD
   Rudebeck, PH
   Chudasama, Y
   Murray, EA
   Averbeck, BB
AF Jang, Anthony I.
   Costa, Vincent D.
   Rudebeck, Peter H.
   Chudasama, Yogita
   Murray, Elisabeth A.
   Averbeck, Bruno B.
TI The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in
   Learning a Bayesian Prior Belief on Reversals
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE amygdala; Bayesian prior; learning set; medial prefrontal cortex;
   orbitofrontal cortex; reversal learning
ID ORBITAL PREFRONTAL CORTEX; RHESUS-MONKEYS; ORBITOFRONTAL CORTEX;
   PERIRHINAL CORTEX; REWARD-VALUE; LESIONS; AMYGDALA; BEHAVIOR; ABLATIONS;
   OBJECT
AB Reversal learning has been extensively studied across species as a task that indexes the ability to flexibly make and reverse deterministic stimulus-reward associations. Although various brain lesions have been found to affect performance on this task, the behavioral processes affected by these lesions have not yet been determined. This task includes at least two kinds of learning. First, subjects have to learn and reverse stimulus-reward associations in each block of trials. Second, subjects become more proficient at reversing choice preferences as they experience more reversals. We have developed a Bayesian approach to separately characterize these two learning processes. Reversal of choice behavior within each block is driven by a combination of evidence that a reversal has occurred, and a prior belief in reversals that evolves with experience across blocks. We applied the approach to behavior obtained from 89 macaques, comprising 12 lesion groups and a control group. We found that animals from all of the groups reversed more quickly as they experienced more reversals, and correspondingly they updated their prior beliefs about reversals at the same rate. However, the initial values of the priors that the various groups of animals brought to the task differed significantly, and it was these initial priors that led to the differences in behavior. Thus, by taking a Bayesian approach we find that variability in reversal-learning performance attributable to different neural systems is primarily driven by different prior beliefs about reversals that each group brings to the task.
C1 [Jang, Anthony I.; Costa, Vincent D.; Rudebeck, Peter H.; Chudasama, Yogita; Murray, Elisabeth A.; Averbeck, Bruno B.] NIMH, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA.
RP Averbeck, BB (reprint author), NIMH, Neuropsychol Lab, NIH, Bldg 49 Room 1B80,49 Convent Dr MSC 4415, Bethesda, MD 20892 USA.
EM bruno.averbeck@nih.gov
OI Rudebeck, Peter/0000-0002-1411-7555; Costa, Vincent/0000-0002-5412-8945
FU Intramural Research Program of the National Institute of Mental Health
FX This work was supported by the Intramural Research Program of the
   National Institute of Mental Health. We thank Alicia Izquierdo, Dawn
   Anuszkiewicz-Lundgren, Katherine Wright, Wendy Hadfield, Robin Suda, and
   Anna Prescott for behavioral testing.
NR 34
TC 7
Z9 7
U1 3
U2 11
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 19
PY 2015
VL 35
IS 33
BP 11751
EP 11760
DI 10.1523/JNEUROSCI.1594-15.2015
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA CT0PW
UT WOS:000362499700026
PM 26290251
ER

PT J
AU Bondy, A
   Cumming, B
AF Bondy, Adrian
   Cumming, Bruce
TI Synchronous Spikes Are More Effective (but Not for Long)
SO NEURON
LA English
DT Editorial Material
ID ACTIVITY PROPAGATION; CORTICAL CIRCUITS; SPIKING ACTIVITY; CORTEX;
   SYNCHRONIZATION; COMPUTATION; INTEGRATION; NEURONS; GAMMA
AB The efficacy of spiking synchrony in corticocortical communication is poorly understood. A new study (Zandvakili and Kohn, 2015) in this issue provides compelling evidence that synchrony in a source population is not efficacious beyond the input layers of the target population.
C1 [Bondy, Adrian; Cumming, Bruce] NEI, NIH, Sensorimotor Res Lab, Bethesda, MD 20892 USA.
   [Bondy, Adrian] Brown Univ, Brown NIH Neurosci Grad Partnership Program, Providence, RI 02912 USA.
RP Bondy, A (reprint author), NEI, NIH, Sensorimotor Res Lab, 49 Convent Dr,2A50, Bethesda, MD 20892 USA.
EM adrian.bondy@gmail.com
NR 16
TC 0
Z9 0
U1 1
U2 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD AUG 19
PY 2015
VL 87
IS 4
BP 676
EP 678
DI 10.1016/j.neuron.2015.08.011
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA CR2GW
UT WOS:000361145600002
PM 26291152
ER

PT J
AU Choy, DF
   Hart, KM
   Borthwick, LA
   Shikotra, A
   Nagarkar, DR
   Siddiqui, S
   Jia, GQ
   Ohri, CM
   Doran, E
   Vannella, KM
   Butler, CA
   Hargadon, B
   Sciurba, JC
   Gieseck, RL
   Thompson, RW
   White, S
   Abbas, AR
   Jackman, J
   Wu, LC
   Egen, JG
   Heaney, LG
   Ramalingam, TR
   Arron, JR
   Wynn, TA
   Bradding, P
AF Choy, David F.
   Hart, Kevin M.
   Borthwick, Lee A.
   Shikotra, Aarti
   Nagarkar, Deepti R.
   Siddiqui, Salman
   Jia, Guiquan
   Ohri, Chandra M.
   Doran, Emma
   Vannella, Kevin M.
   Butler, Claire A.
   Hargadon, Beverley
   Sciurba, Joshua C.
   Gieseck, Richard L.
   Thompson, Robert W.
   White, Sandra
   Abbas, Alexander R.
   Jackman, Janet
   Wu, Lawren C.
   Egen, Jackson G.
   Heaney, Liam G.
   Ramalingam, Thirumalai R.
   Arron, Joseph R.
   Wynn, Thomas A.
   Bradding, Peter
TI T(H)2 and T(H)17 inflammatory pathways are reciprocally regulated in
   asthma
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; THYMIC STROMAL LYMPHOPOIETIN; AIRWAY
   HYPERRESPONSIVENESS; T-CELLS; ALLERGIC INFLAMMATION; EOSINOPHILIC
   ASTHMA; BIOLOGIC THERAPIES; DEPENDENT ASTHMA; CLUSTER-ANALYSIS;
   MAST-CELLS
AB Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: T(H)2-high, T(H)17-high, and T(H)2/17-low. T(H)2-high and T(H)17-high patterns were mutually exclusive in individual patient samples, and their gene signatures were inversely correlated and differentially regulated by interleukin-13 (IL-13) and IL-17A. To understand this dichotomous pattern of T helper 2 (T(H)2) and T(H)17 signatures, we investigated the potential of type 2 cytokine suppression in promoting T(H)17 responses in a preclinical model of allergen-induced asthma. Neutralization of IL-4 and/or IL-13 resulted in increased T(H)17 cells and neutrophilic inflammation in the lung. However, neutralization of IL-13 and IL-17 protected mice from eosinophilia, mucus hyperplasia, and airway hyperreactivity and abolished the neutrophilic inflammation, suggesting that combination therapies targeting both pathways may maximize therapeutic efficacy across a patient population comprising both T(H)2 and T(H)17 endotypes.
C1 [Choy, David F.; Nagarkar, Deepti R.; Jia, Guiquan; Doran, Emma; Abbas, Alexander R.; Jackman, Janet; Wu, Lawren C.; Egen, Jackson G.; Arron, Joseph R.] Genentech Inc, San Francisco, CA 94080 USA.
   [Hart, Kevin M.; Vannella, Kevin M.; Sciurba, Joshua C.; Gieseck, Richard L.; Thompson, Robert W.; White, Sandra; Ramalingam, Thirumalai R.; Wynn, Thomas A.] NIAID, Program Tissue Immun & Repair, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
   [Borthwick, Lee A.] Newcastle Univ, Inst Cellular Med, Tissue Fibrosis & Repair Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
   [Shikotra, Aarti; Siddiqui, Salman; Ohri, Chandra M.; Hargadon, Beverley; Bradding, Peter] Univ Leicester, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester LE3 9QP, Leics, England.
   [Doran, Emma; Butler, Claire A.; Heaney, Liam G.] Queens Univ Belfast, Ctr Infect & Immun, Belfast BT9 7AB, Antrim, North Ireland.
RP Arron, JR (reprint author), Genentech Inc, San Francisco, CA 94080 USA.
EM arron.joseph@gene.com; arron.joseph@gene.com
OI Borthwick, Lee/0000-0003-2885-3382; Bradding, Peter/0000-0001-8403-0319
FU Intramural Research Program of the NIH; NIAID; Asthma UK
   [AUK-PG-2013-208]; Genentech Inc.; National Institute for Health
   Research (NIHR) Leicester Respiratory Biomedical Research Unit
FX Funding: Supported in part by the Intramural Research Program of the
   NIH, NIAID. Work in Leicester was supported by grants from the Asthma UK
   project grant AUK-PG-2013-208 and a grant-in-aid from Genentech Inc.,
   and was supported by the National Institute for Health Research (NIHR)
   Leicester Respiratory Biomedical Research Unit. The views expressed are
   those of the author(s) and not necessarily those of the National Health
   Service (NHS), the NIHR, or the Department of Health.
NR 63
TC 44
Z9 44
U1 5
U2 13
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD AUG 19
PY 2015
VL 7
IS 301
AR 301ra129
DI 10.1126/scitranslmed.aab3142
PG 10
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA CQ9NK
UT WOS:000360941700003
PM 26290411
ER

PT J
AU Muthumani, K
   Falzarano, D
   Reuschel, EL
   Tingey, C
   Flingai, S
   Villarreal, DO
   Wise, M
   Patel, A
   Izmirly, A
   Aljuaid, A
   Seliga, AM
   Soule, G
   Morrow, M
   Kraynyak, KA
   Khan, AS
   Scott, DP
   Feldmann, F
   LaCasse, R
   Meade-White, K
   Okumura, A
   Ugen, KE
   Sardesai, NY
   Kim, JJ
   Kobinger, G
   Feldmann, H
   Weiner, DB
AF Muthumani, Karuppiah
   Falzarano, Darryl
   Reuschel, Emma L.
   Tingey, Colleen
   Flingai, Seleeke
   Villarreal, Daniel O.
   Wise, Megan
   Patel, Ami
   Izmirly, Abdullah
   Aljuaid, Abdulelah
   Seliga, Alecia M.
   Soule, Geoff
   Morrow, Matthew
   Kraynyak, Kimberly A.
   Khan, Amir S.
   Scott, Dana P.
   Feldmann, Friederike
   LaCasse, Rachel
   Meade-White, Kimberly
   Okumura, Atsushi
   Ugen, Kenneth E.
   Sardesai, Niranjan Y.
   Kim, J. Joseph
   Kobinger, Gary
   Feldmann, Heinz
   Weiner, David B.
TI A synthetic consensus anti-spike protein DNA vaccine induces protective
   immunity against Middle East respiratory syndrome coronavirus in
   nonhuman primates
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID MERS-COV; NEUTRALIZING ANTIBODIES; RHESUS MACAQUES; SARS CORONAVIRUS;
   INFECTIONS; RECEPTOR; VIRUS; MICE; STRATEGIES; EVOLUTION
AB First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging human coronavirus, which is distinct from the severe acute respiratory syndrome coronavirus (SARS-CoV), and represents a novel member of the lineage C betacoronoviruses. Since its identification, MERS coronavirus (MERS-CoV) has been linked to more than 1372 infections manifesting with severe morbidity and, often, mortality (about 495 deaths) in the Arabian Peninsula, Europe, and, most recently, the United States. Human-to-human transmission has been documented, with nosocomial transmission appearing to be an important route of infection. The recent increase in cases of MERS in the Middle East coupled with the lack of approved antiviral therapies or vaccines to treat or prevent this infection are causes for concern. We report on the development of a synthetic DNA vaccine against MERS-CoV. An optimized DNA vaccine encoding the MERS spike protein induced potent cellular immunity and antigen-specific neutralizing antibodies in mice, macaques, and camels. Vaccinated rhesus macaques seroconverted rapidly and exhibited high levels of virus-neutralizing activity. Upon MERS viral challenge, all of the monkeys in the control-vaccinated group developed characteristic disease, including pneumonia. Vaccinated macaques were protected and failed to demonstrate any clinical or radiographic signs of pneumonia. These studies demonstrate that a consensus MERS spike protein synthetic DNA vaccine can induce protective responses against viral challenge, indicating that this strategy may have value as a possible vaccine modality against this emerging pathogen.
C1 [Muthumani, Karuppiah; Reuschel, Emma L.; Tingey, Colleen; Flingai, Seleeke; Villarreal, Daniel O.; Wise, Megan; Patel, Ami; Izmirly, Abdullah; Aljuaid, Abdulelah; Seliga, Alecia M.; Weiner, David B.] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
   [Falzarano, Darryl; Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, Rocky Mt Labs,NIH, Hamilton, MT 59840 USA.
   [Soule, Geoff] Univ Manitoba, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada.
   [Soule, Geoff; Kobinger, Gary] Publ Hlth Agcy Canada, Winnipeg, MB R3E 3R2, Canada.
   [Morrow, Matthew; Kraynyak, Kimberly A.; Khan, Amir S.; Sardesai, Niranjan Y.; Kim, J. Joseph] Inovio Pharmaceut Inc, Plymouth Meeting, PA 19462 USA.
   [Scott, Dana P.; Feldmann, Friederike; LaCasse, Rachel; Meade-White, Kimberly] NIAID, Rocky Mt Vet Branch, Div Intramural Res, NIH, Hamilton, MT 59840 USA.
   [Okumura, Atsushi] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA.
   [Ugen, Kenneth E.] Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33612 USA.
RP Weiner, DB (reprint author), Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
EM dbweiner@mail.med.upenn.edu
RI Muthumani, Karuppiah/D-1092-2009; Ugen, Kenneth/H-6544-2011; Okumura,
   Atsushi/E-8012-2015
OI Okumura, Atsushi/0000-0002-7779-3059
FU Intramural Research Program of the National Institute of Allergy and
   Infectious Diseases of NIH [R01-AI092843]; Inovio Pharmaceuticals Inc.
FX Funding: This work was partially funded by the Intramural Research
   Program of the National Institute of Allergy and Infectious Diseases of
   NIH and R01-AI092843 to D.B.W. D.B.W. and K.M. also note funding by
   Inovio Pharmaceuticals Inc.
NR 53
TC 5
Z9 6
U1 0
U2 5
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD AUG 19
PY 2015
VL 7
IS 301
AR 301ra132
DI 10.1126/scitranslmed.aac7462
PG 14
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA CQ9NK
UT WOS:000360941700006
PM 26290414
ER

PT J
AU Wang, Y
   Li, Y
   Cao, HB
   Xiong, MM
   Shugart, YY
   Jin, L
AF Wang, Yi
   Li, Yi
   Cao, Hongbao
   Xiong, Momiao
   Shugart, Yin Yao
   Jin, Li
TI Efficient test for nonlinear dependence of two continuous variables
SO BMC BIOINFORMATICS
LA English
DT Article
DE CANOVA; Linear/nonlinear correlation; Neighborhood; Power; Kidney cancer
ID MAXIMAL INFORMATION COEFFICIENT; EQUITABILITY; REGRESSION; DISTANCES;
   CANCER; GENE
AB Background: Testing dependence/correlation of two variables is one of the fundamental tasks in statistics. In this work, we proposed a new way of testing nonlinear dependence between two continuous variables (X and Y).
   Results: We addressed this research question by using CANOVA (continuous analysis of variance, software available at https://sourceforge.net/projects/canova/). In the CANOVA framework, we first defined a neighborhood for each data point related to its X value, and then calculated the variance of the Y value within the neighborhood. Finally, we performed permutations to evaluate the significance of the observed values within the neighborhood variance. To evaluate the strength of CANOVA compared to six other methods, we performed extensive simulations to explore the relationship between methods and compared the false positive rates and statistical power using both simulated and real datasets (kidney cancer RNA-seq dataset).
   Conclusions: We concluded that CANOVA is an efficient method for testing nonlinear correlation with several advantages in real data applications.
C1 [Wang, Yi; Li, Yi; Jin, Li] Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Key Lab Contemporary Anthropol, Sch Life Sci,Minist Educ, Shanghai 200433, Peoples R China.
   [Cao, Hongbao; Shugart, Yin Yao] NIMH, Unit Stat Genom, Div Intramural Div Programs, NIH, Bethesda, MD 20892 USA.
   [Xiong, Momiao] Univ Texas Houston Hlth Sci Ctr, Sch Publ Hlth, Ctr Human Genet, Houston, TX USA.
   [Shugart, Yin Yao] NIMH, Div Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Jin, Li] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China.
RP Shugart, YY (reprint author), NIMH, Unit Stat Genom, Div Intramural Div Programs, NIH, Bethesda, MD 20892 USA.
EM yin.yao@nih.gov; lijin@fudan.edu.cn
RI Jin, Li/C-1468-2009
OI Jin, Li/0000-0002-4546-2415
FU National Science Foundation of China [31330038]; National Basic Research
   Program [2012CB944600]; 111 Project [B13016]; IRP [MH002930-04]; Fudan
   University High-End Computing Center
FX This research was supported by National Science Foundation of China
   (31330038), the National Basic Research Program (2012CB944600), and the
   111 Project (B13016). Shugart was supported by IRP (Project number
   MH002930-04). The computations involved in this study were supported by
   Fudan University High-End Computing Center.
NR 43
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U2 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD AUG 19
PY 2015
VL 16
AR 260
DI 10.1186/s12859-015-0697-7
PG 8
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
   Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Mathematical & Computational Biology
GA CP1EQ
UT WOS:000359619500003
PM 26283601
ER

PT J
AU Hahnke, VD
   Bolton, EE
   Bryant, SH
AF Haehnke, Volker D.
   Bolton, Evan E.
   Bryant, Stephen H.
TI PubChem atom environments
SO JOURNAL OF CHEMINFORMATICS
LA English
DT Article
DE Molecular graph; PubChem; Fragment; Standardization; SMARTS
ID DESCRIPTOR LANGUAGE MCDL; COMPUTER-BASED FILE; LINE NOTATION SLN;
   CHEMICAL-STRUCTURES; STRUCTURAL CHARACTERISTICS; QUANTUM CONTRIBUTIONS;
   BENZENE PROBLEM; MDL KEYS; SIMILARITY; SYSTEM
AB Background: Atom environments and fragments find wide-spread use in chemical information and cheminformatics. They are the basis of prediction models, an integral part in similarity searching, and employed in structure search techniques. Most of these methods were developed and evaluated on the relatively small sets of chemical structures available at the time. An analysis of fragment distributions representative of most known chemical structures was published in the 1970s using the Chemical Abstracts Service data system. More recently, advances in automated synthesis of chemicals allow millions of chemicals to be synthesized by a single organization. In addition, open chemical databases are readily available containing tens of millions of chemical structures from a multitude of data sources, including chemical vendors, patents, and the scientific literature, making it possible for scientists to readily access most known chemical structures. With this availability of information, one can now address interesting questions, such as: what chemical fragments are known today? How do these fragments compare to earlier studies? How unique are chemical fragments found in chemical structures?
   Results: For our analysis, after hydrogen suppression, atoms were characterized by atomic number, formal charge, implicit hydrogen count, explicit degree (number of neighbors), valence (bond order sum), and aromaticity. Bonds were differentiated as single, double, triple or aromatic bonds. Atom environments were created in a circular manner focused on a central atom with radii from 0 (atom types) up to 3 (representative of ECFP_6 fragments). In total, combining atom types and atom environments that include up to three spheres of nearest neighbors, our investigation identified 28,462,319 unique fragments in the 46 million structures found in the PubChem Compound database as of January 2013. We could identify several factors inflating the number of environments involving transition metals, with many seemingly due to erroneous interpretation of structures from patent data. Compared to fragmentation statistics published 40 years ago, the exponential growth in chemistry is mirrored in a nearly eightfold increase in the number of unique chemical fragments; however, this result is clearly an upper bound estimate as earlier studies employed structure sampling approaches and this study shows that a relatively high rate of atom fragments are found in only a single chemical structure (singletons). In addition, the percentage of singletons grows as the size of the chemical fragment is increased.
   Conclusions: The observed growth of the numbers of unique fragments over time suggests that many chemically possible connections of atom types to larger fragments have yet to be explored by chemists. A dramatic drop in the relative rate of increase of atom environments from smaller to larger fragments shows that larger fragments mainly consist of diverse combinations of a limited subset of smaller fragments. This is further supported by the observed concomitant increase of singleton atom environments. Combined, these findings suggest that there is considerable opportunity for chemists to combine known fragments to novel chemical compounds. The comparison of PubChem to an older study of known chemical structures shows noticeable differences. The changes suggest advances in synthetic capabilities of chemists to combine atoms in new patterns. Log-log plots of fragment incidence show small numbers of fragments are found in many structures and that large numbers of fragments are found in very few structures, with nearly half being novel using the methods in this work. The relative decrease in the count of new fragments as a function of size further suggests considerable opportunity for more novel chemicals exists. Lastly, the differences in atom environment diversity between PubChem Substance and Compound showcase the effect of PubChem standardization protocols, but also indicate that a normalization procedure for atom types, functional groups, and tautomeric/resonance forms based on atom environments is possible. The complete sets of atom types and atom environments are supplied as supporting information.
C1 [Haehnke, Volker D.; Bolton, Evan E.; Bryant, Stephen H.] Natl Lib Med, Dept Hlth & Human Serv, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.
RP Bolton, EE (reprint author), Natl Lib Med, Dept Hlth & Human Serv, Natl Ctr Biotechnol Informat, NIH, 8600 Rockville Pike, Bethesda, MD 20894 USA.
EM bolton@ncbi.nlm.nih.gov
FU Intramural Research Program of the National Library of Medicine,
   National Institutes of Health, US Department of Health and Human
   Services
FX We thank the anonymous reviewers for their careful reading of our
   manuscript and their constructive comments, which helped us to improve
   the manuscript. This research was supported in part by the Intramural
   Research Program of the National Library of Medicine, National
   Institutes of Health, US Department of Health and Human Services.
NR 79
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U1 2
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-2946
J9 J CHEMINFORMATICS
JI J. Cheminformatics
PD AUG 19
PY 2015
VL 7
AR 41
DI 10.1186/s13321-015-0076-4
PG 37
WC Chemistry, Multidisciplinary; Computer Science, Information Systems;
   Computer Science, Interdisciplinary Applications
SC Chemistry; Computer Science
GA CP2EN
UT WOS:000359690400003
PM 26300985
ER

PT J
AU Denniston, AK
   Holland, GN
   Kidess, A
   Nussenblatt, RB
   Okada, AA
   Rosenbaum, JT
   Dick, AD
AF Denniston, Alastair K.
   Holland, Gary N.
   Kidess, Andrej
   Nussenblatt, Robert B.
   Okada, Annabelle A.
   Rosenbaum, James T.
   Dick, Andrew D.
TI Heterogeneity of primary outcome measures used in clinical trials of
   treatments for intermediate, posterior, and panuveitis
SO ORPHANET JOURNAL OF RARE DISEASES
LA English
DT Review
DE Uveitis; Clinical trials; Outcome measures; Endpoints; Composite
   endpoints
ID OPTICAL COHERENCE TOMOGRAPHY; STEROID-TREATMENT-TRIAL; DEXAMETHASONE
   INTRAVITREAL IMPLANT; CYSTOID MACULAR EDEMA; QUALITY-OF-LIFE; VISUAL
   FUNCTION; NONINFECTIOUS INTERMEDIATE; UVEITIS; DISEASE; STANDARDIZATION
AB Background: Uveitis describes a heterogeneous group of conditions characterized by intraocular inflammation. Since most of the sight-threatening forms of uveitis are individually rare, there has been an increasing tendency for clinical trials to group distinct uveitis syndromes together despite clear variations in phenotype which may reflect real aetiological and pathogenetic differences. Furthermore this grouping of distinct syndromes, and the range of manifestations within each uveitis syndrome, leads to a wide range of possible outcome measures. In this study we wished to review the degree of consensus or otherwise in the choice of primary outcome measures for registered clinical trials related to uveitis.
   Methods: Systematic review of data provided in clinical trial registries describing clinical trials dealing with medical treatment of intermediate, posterior, or panuveitis through 01 October 2013. We reviewed 15 on-line clinical trial registries approved by the International Committee of Medical Journal Editors. We identified all that met the following inclusion criteria: prospective, interventional design; target populations with intermediate, posterior or panuveitis; and one or more pre-specified outcome measures that were related to uveitis. Primary outcome measures were classified in terms of type (efficacy or safety or both; single, composite, or multiple); dimension (disease activity, disease damage, measured or patient-reported visual function); and domain (the specific study variable being measured).
   Results: Of 195 registered uveitis studies, we identified 104 clinical trials that met inclusion criteria. There were 14 different domains used as primary outcome measures. Among clinical trials that utilized primary outcome measures of treatment efficacy (n = 94), 70 (74 %) used a measure of disease activity (vitreous haze in 40/70 [57 %]; macular oedema in 19/70 [27 %]) and 49 (70 %) used a measure of visual function (visual acuity in all cases). Multiple primary outcome measures were used in 23 (22 %) of 104 clinical trials. With regard to quality, in 12 (12 %) of 104 clinical trials, outcome measures were poorly defined. No clinical trial utilized a patient-reported study variable as primary outcome measure.
   Conclusions: This systematic review highlights the heterogeneity of outcome measures used in recent clinical trials for intermediate, posterior, and panuveitis. Current designs prioritize clinician-observed measures of disease activity and measurement of visual function as outcome measures. This apparent lack of consensus regarding outcome measures for the study of uveitis is a concern, as it prevents comparison of studies and meta-analyses, and weakens the evidence available to stake-holders, from patients to clinicians to regulators, regarding the efficacy and value of a given treatment.
C1 [Denniston, Alastair K.; Kidess, Andrej] Univ Birmingham, Inst Translat Med, Birmingham Hlth Partners, Birmingham, W Midlands, England.
   [Denniston, Alastair K.] Queen Elizabeth Hosp, Queen Univ Hosp Birmingham, Dept Ophthalmol, Birmingham B15 2TH, W Midlands, England.
   [Holland, Gary N.] Univ Calif Los Angeles, Stein Eye Inst, Los Angeles, CA 90095 USA.
   [Holland, Gary N.] Univ Calif Los Angeles, David Geffen Sch Med, Ocular Inflammatory Dis Ctr, Dept Ophthalmol, Los Angeles, CA 90095 USA.
   [Nussenblatt, Robert B.] NEI, NIH, Bethesda, MD 20892 USA.
   [Okada, Annabelle A.] Kyorin Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan.
   [Rosenbaum, James T.] Oregon Hlth & Sci Univ, Casey Eye Inst, USA Legacy Devers Eye Inst, Dept Ophthalmol, Portland, OR 97201 USA.
   [Dick, Andrew D.] Univ Hosp Bristol NHS Fdn Trust, Bristol Eye Hosp, Bristol, Avon, England.
   [Dick, Andrew D.] Univ Bristol, Acad Unit Ophthalmol, Bristol, Avon, England.
   [Dick, Andrew D.] Moorfields Eye Hosp NHS Fdn, NIHR Biomed Res Ctr Ophthalmol, London, England.
   [Dick, Andrew D.] Inst Ophthalmol, London, England.
RP Denniston, AK (reprint author), Univ Birmingham, Inst Translat Med, Birmingham Hlth Partners, Birmingham, W Midlands, England.
EM a.denniston@bham.ac.uk
OI Denniston, Alastair/0000-0001-7849-0087
FU Novartis Pharma K.K. (Japan); Bayer Yakuhin, Ltd. (Japan); Mitsubishi
   Tanabe Pharma Corporation; Pfizer Japan, Inc.; Santen Pharmaceutical
   Co., Ltd.; NIH; Spondylitis Association of America
FX Dr. Okada has received lecture fees from the following companies:
   Novartis Pharma K.K. (Japan); Bayer Yakuhin, Ltd. (Japan); Mitsubishi
   Tanabe Pharma Corporation; Pfizer Japan, Inc.; and Santen Pharmaceutical
   Co., Ltd. She has also served on Advisory Boards or provided
   consultation for the following companies: Novartis AG; Novartis Pharma
   K.K. (Japan); Bayer Healthcare AG; and Xoma Corporation.; Dr Rosenbaum
   has received clinical trial support from Genentech, Lux, Abbvie,
   Celgene, Xoma, Eyegate and Bristol-Myers Squibb. He has also served as a
   consultant for Genentech, Allergan, Santen, Xoma, Regeneron, Sanofi,
   Teva, EMD Serono, Novartis, UCB and Abbvie. He also receives financial
   support from the NIH and the Spondylitis Association of America. Prof.
   Dick has served on Advisory Boards for the following companies:
   Novartis, Abbvie and Qchips.
NR 36
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U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1750-1172
J9 ORPHANET J RARE DIS
JI Orphanet J. Rare Dis.
PD AUG 19
PY 2015
VL 10
AR 97
DI 10.1186/s13023-015-0318-6
PG 11
WC Genetics & Heredity; Medicine, Research & Experimental
SC Genetics & Heredity; Research & Experimental Medicine
GA CP2UW
UT WOS:000359733700002
PM 26286265
ER

PT J
AU Handel, A
   Rohani, P
AF Handel, Andreas
   Rohani, Pejman
TI Crossing the scale from within-host infection dynamics to between-host
   transmission fitness: a discussion of current assumptions and knowledge
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE multi-scale; infectious disease; computational models
ID A VIRUS-INFECTION; EXPERIMENTAL HUMAN INFLUENZA; VIRAL LOAD; TRADE-OFF;
   HOUSEHOLD TRANSMISSION; ZANAMIVIR TREATMENT; PANDEMIC INFLUENZA; HIV-1
   TRANSMISSION; DISEASE DYNAMICS; BRIDGING SCALES
AB The progression of an infection within a host determines the ability of a pathogen to transmit to new hosts and to maintain itself in the population. While the general connection between the infection dynamics within a host and the population-level transmission dynamics of pathogens is widely acknowledged, a comprehensive and quantitative understanding that would allow full integration of the two scales is still lacking. Here, we provide a brief discussion of both models and data that have attempted to provide quantitative mappings from within-host infection dynamics to transmission fitness. We present a conceptual framework and provide examples of studies that have taken first steps towards development of a quantitative framework that scales from within-host infections to population-level fitness of different pathogens. We hope to illustrate some general themes, summarize some of the recent advances and maybe most importantly discuss gaps in our ability to bridge these scales, and to stimulate future research on this important topic.
C1 [Handel, Andreas] Univ Georgia, Coll Publ Hlth, Dept Epidemiol & Biostat, Athens, GA 30602 USA.
   [Rohani, Pejman] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
   [Rohani, Pejman] Univ Michigan, Ctr Study Complex Syst, Ann Arbor, MI 48109 USA.
   [Rohani, Pejman] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Handel, A (reprint author), Univ Georgia, Coll Publ Hlth, Dept Epidemiol & Biostat, Athens, GA 30602 USA.
EM ahandel@uga.edu
FU RAPIDD programme of the Science and Technology Directorate, Department
   of Homeland Security; MIDAS, National Institute of General Medical
   Sciences [U54-GM111274, U01-GM110744]; NSF
FX P.R. was supported by the RAPIDD programme of the Science and Technology
   Directorate, Department of Homeland Security, and by MIDAS, National
   Institute of General Medical Sciences U54-GM111274 and U01-GM110744. The
   opinions expressed herein are those of the author(s) and do not
   necessarily reflect the views of any of the funding agencies.
   Discussions and the invitation to submit this article, arose from a
   NESCent working group and the NSF supported Research Coordination
   Network on Infectious Disease Evolution across Scales.
NR 119
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U1 3
U2 31
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD AUG 19
PY 2015
VL 370
IS 1675
AR 20140302
DI 10.1098/rstb.2014.0302
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA CN9HU
UT WOS:000358758700016
ER

PT J
AU Jabbi, M
   Chen, Q
   Turner, N
   Kohn, P
   White, M
   Kippenhan, JS
   Dickinson, D
   Kolachana, B
   Mattay, V
   Weinberger, DR
   Berman, KF
AF Jabbi, M.
   Chen, Q.
   Turner, N.
   Kohn, P.
   White, M.
   Kippenhan, J. S.
   Dickinson, D.
   Kolachana, B.
   Mattay, V.
   Weinberger, D. R.
   Berman, K. F.
TI Variation in the Williams syndrome GTF2I gene and anxiety proneness
   interactively affect prefrontal cortical response to aversive stimuli
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID SEPARATION ANXIETY; AMYGDALA; DISORDERS; CONNECTIVITY; DUPLICATION;
   CHILDHOOD; HUMANS; CORTEX; LOCUS; FACES
AB Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for behavioral neuroscience. Copy-number variation (CNV) in the general transcription factor gene, GTF2I, located in the 7q11.23 chromosomal region that is hemideleted in Williams syndrome and duplicated in the 7q11.23 duplication syndrome (Dup7), is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7. Because of this recent preclinical and clinical identification of a genetic influence on anxiety, we examined whether sequence variation in GTF2I, specifically the single-nucleotide polymorphism rs2527367, interacts with trait and state anxiety to collectively impact neural response to anxiety-laden social stimuli. Two hundred and sixty healthy adults completed the Tridimensional Personality Questionnaire Harm Avoidance (HA) subscale, a trait measure of anxiety proneness, and underwent functional magnetic resonance imaging (fMRI) while matching aversive (fearful or angry) facial identity. We found an interaction between GTF2I allelic variations and HA that affects brain response: in individuals homozygous for the major allele, there was no correlation between HA and whole-brain response to aversive cues, whereas in heterozygotes and individuals homozygous for the minor allele, there was a positive correlation between HA sub-scores and a selective dorsolateral prefrontal cortex (DLPFC) responsivity during the processing of aversive stimuli. These results demonstrate that sequence variation in the GTF2I gene influences the relationship between trait anxiety and brain response to aversive social cues in healthy individuals, supporting a role for this neurogenetic mechanism in anxiety.
C1 [Jabbi, M.; Turner, N.; Kohn, P.; Kippenhan, J. S.; Berman, K. F.] NIMH, Sect Integrat Neuroimaging, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Jabbi, M.; Turner, N.; Kohn, P.; Kippenhan, J. S.; Dickinson, D.; Kolachana, B.; Berman, K. F.] NIMH, Clin & Translat Neurosci Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Chen, Q.; White, M.; Mattay, V.; Weinberger, D. R.] Lieber Inst Brain Dev, Baltimore, MD USA.
   [Mattay, V.] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA.
   [Weinberger, D. R.] Johns Hopkins Sch Med, Dept Psychiat, Baltimore, MD USA.
   [Weinberger, D. R.] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA.
   [Weinberger, D. R.] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA.
   [Weinberger, D. R.] Johns Hopkins Sch Med, McKusick Nathans Inst Genom Med, Baltimore, MD USA.
RP Jabbi, M (reprint author), NIMH, Clin & Translat Neurosci Branch, Intramural Res Program, NIH, 9000 Rockville Pike,Room 3C113, Bethesda, MD 20892 USA.
EM jabbim@gmail.com; karen.berman@nih.gov
FU Intramural Research Program of the National Institute of Mental Health,
   National Institutes of Health
FX We thank our colleagues at the NIH NMR center for their support. We
   thank Dr Joseph Callicott for his guidance on the genotyping approach.
   The Intramural Research Program of the National Institute of Mental
   Health, National Institutes of Health, funded this work.
NR 34
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U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG 18
PY 2015
VL 5
AR e622
DI 10.1038/tp.2015.98
PG 5
WC Psychiatry
SC Psychiatry
GA DA2YB
UT WOS:000367662000004
PM 26285132
ER

PT J
AU Jaswal, DS
   Eichacker, PQ
AF Jaswal, Dharmvir S.
   Eichacker, Peter Q.
TI In early septic shock, early goal-directed therapy did not reduce 90-day
   mortality
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Editorial Material
ID SEVERE SEPSIS
C1 [Jaswal, Dharmvir S.; Eichacker, Peter Q.] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Jaswal, DS (reprint author), NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD AUG 18
PY 2015
VL 163
IS 4
BP JC10
EP JC10
DI 10.7326/ACPJC-2015-163-4-010
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CW0IT
UT WOS:000364673500016
ER

PT J
AU Sylvetsky, AC
   Gardner, AL
   Bauman, V
   Blau, JE
   Garraffo, HM
   Walter, PJ
   Rother, KI
AF Sylvetsky, Allison C.
   Gardner, Alexandra L.
   Bauman, Viviana
   Blau, Jenny E.
   Garraffo, H. Martin
   Walter, Peter J.
   Rother, Kristina I.
TI NONNUTRITIVE SWEETENERS IN BREAST MILK
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID ENVIRONMENTAL CHEMICALS; SURVEILLANCE; PREGNANCY; LACTATION; EXPOSURE;
   LIFE
AB Nonnutritive sweeteners (NNS), including saccharin, sucralose, aspartame, and acesulfame-potassium, are commonly consumed in the general population, and all except for saccharin are considered safe for use during pregnancy and lactation. Sucralose (Splenda) currently holds the majority of the NNS market share and is often combined with acesulfame-potassium in a wide variety of foods and beverages. To date, saccharin is the only NNS reported to be found in human breast milk after maternal consumption, while there is no apparent information on the other NNS. Breast milk samples were collected from 20 lactating volunteers, irrespective of their habitual NNS intake. Saccharin, sucralose, and acesulfame-potassium were present in 65% of participants' milk samples, whereas aspartame was not detected. These data indicate that NNS are frequently ingested by nursing infants, and thus prospective clinical studies are necessary to determine whether early NNS exposure via breast milk may have clinical implications.
C1 [Sylvetsky, Allison C.; Gardner, Alexandra L.; Bauman, Viviana; Blau, Jenny E.; Rother, Kristina I.] Natl Inst Diabet & Digest & Kidney Dis, Sect Pediat Diabet & Metab, NIH, Bethesda, MD USA.
   [Sylvetsky, Allison C.] George Washington Univ, Milken Inst Sch Publ Hlth, Dept Exercise & Nutr Sci, Washington, DC USA.
   [Garraffo, H. Martin; Walter, Peter J.] Natl Inst Diabet & Digest & Kidney Dis, Clin Mass Spectrometry Core, NIH, Bethesda, MD USA.
RP Rother, KI (reprint author), Bldg 10,Room 8C-432A,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM kristina.rother@nih.gov
FU National Institute of Diabetes, Digestive and Kidney Diseases at the
   National Institutes of Health (Bethesda, MD)
FX This work was supported by the intramural research program at the
   National Institute of Diabetes, Digestive and Kidney Diseases at the
   National Institutes of Health (Bethesda, MD).
NR 17
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U1 1
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD AUG 18
PY 2015
VL 78
IS 16
BP 1029
EP 1032
DI 10.1080/15287394.2015.1053646
PG 4
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA CW4KB
UT WOS:000364959100001
PM 26267522
ER

PT J
AU Tewari, S
   Spouge, JL
AF Tewari, Susanta
   Spouge, John L.
TI Coalescent: an open-science framework for importance sampling in
   coalescent theory
SO PEERJ
LA English
DT Article
DE Framework; Population genetics; Open-science; Importance sampling;
   Likelihood; Infinite sites model; Coalescent theory
ID POPULATION-GENETICS; RECOMBINATION; INFERENCE; NUMBER; SITES
AB Background. In coalescent theory, computer programs often use importance sampling to calculate likelihoods and other statistical quantities. An importance sampling scheme can exploit human intuition to improve statistical efficiency of computations, but unfortunately, in the absence of general computer frameworks on importance sampling, researchers often struggle to translate new sampling schemes computationally or benchmark against different schemes, in a manner that is reliable and maintainable. Moreover, most studies use computer programs lacking a convenient user interface or the flexibility to meet the current demands of open science. In particular, current computer frameworks can only evaluate the efficiency of a single importance sampling scheme or compare the efficiencies of different schemes in an ad hoc manner.
   Results. We have designed a general framework (http://coalescent.sourceforge.net; language: Java; License: GPLv3) for importance sampling that computes likelihoods under the standard neutral coalescent model of a single, well-mixed population of constant size over time following infinite sites model of mutation. The framework models the necessary core concepts, comes integrated with several data sets of varying size, implements the standard competing proposals, and integrates tightly with our previous framework for calculating exact probabilities. For a given dataset, it computes the likelihood and provides the maximum likelihood estimate of the mutation parameter. Well-known benchmarks in the coalescent literature validate the accuracy of the framework. The framework provides an intuitive user interface with minimal clutter. For performance, the framework switches automatically to modern multicore hardware, if available. It runs on three major platforms (Windows, Mac and Linux). Extensive tests and coverage make the framework reliable and maintainable.\
   Conclusions. In coalescent theory, many studies of computational efficiency consider only effective sample size. Here, we evaluate proposals in the coalescent literature, to discover that the order of efficiency among the three importance sampling schemes changes when one considers running time as well as effective sample size. We also describe a computational technique called "just-in-time delegation" available to improve the trade-off between running time and precision by constructing improved importance sampling schemes from existing ones. Thus, our systems approach is a potential solution to the "2(8) programs problem" highlighted by Felsenstein, because it provides the flexibility to include or exclude various features of similar coalescent models or importance sampling schemes.
C1 [Tewari, Susanta; Spouge, John L.] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
RP Tewari, S (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
EM statsusant@gmail.com
FU National Institutes of Health (NIH); Intramural Research Program of the
   NIH, National Library of Medicine
FX This research was funded in part by National Institutes of Health (NIH);
   Intramural Research Program of the NIH, National Library of Medicine.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD AUG 18
PY 2015
VL 3
AR e1203
DI 10.7717/peerj.1203
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CQ8HC
UT WOS:000360846700013
PM 26312189
ER

PT J
AU Ma, J
   Metrick, M
   Ghirlando, R
   Zhao, HY
   Schuck, P
AF Ma, Jia
   Metrick, Michael
   Ghirlando, Rodolfo
   Zhao, Huaying
   Schuck, Peter
TI Variable-Field Analytical Ultracentrifugation: I. Time-Optimized
   Sedimentation Equilibrium
SO BIOPHYSICAL JOURNAL
LA English
DT Article
ID RAYLEIGH INTERFERENCE OPTICS; SYSTEMATIC NOISE DECOMPOSITION; PROTEIN
   INTERACTIONS; MOLECULAR-WEIGHT; RAPID-DETERMINATION; LAMM EQUATION;
   MASS; CONSERVATION; ASSOCIATION; CONSTRAINTS
AB Sedimentation equilibrium (SE) analytical ultracentrifugation (AUC) is a gold standard for the rigorous determination of macromolecular buoyant molar masses and the thermodynamic study of reversible interactions in solution. A significant experimental drawback is the long time required to attain SE, which is usually on the order of days. We have developed a method for time-optimized SE (toSE) with defined time-varying centrifugal fields that allow SE to be attained in a significantly (up to 10-fold) shorter time than is usually required. To achieve this, numerical Lamm equation solutions for sedimentation in time-varying fields are computed based on initial estimates of macromolecular transport properties. A parameterized rotor-speed schedule is optimized with the goal of achieving a minimal time to equilibrium while limiting transient sample preconcentration at the base of the solution column. The resulting rotor-speed schedule may include multiple over- and underspeeding phases, balancing the formation of gradients from strong sedimentation fluxes with periods of high diffusional transport. The computation is carried out in a new software program called TOSE, which also facilitates convenient experimental implementation. Further, we extend AUG data analysis to sedimentation processes in such time-varying centrifugal fields. Due to the initially high centrifugal fields in toSE and the resulting strong migration, it is possible to extract sedimentation coefficient distributions from the early data. This can provide better estimates of the size of macromolecular complexes and report on sample homogeneity early on, which may be used to further refine the prediction of the rotor-speed schedule. In this manner, the toSE experiment can be adapted in real time to the system under study, maximizing both the information content and the time efficiency of SE experiments.
C1 [Ma, Jia; Metrick, Michael; Zhao, Huaying; Schuck, Peter] NIBIB, Dynam Macromol Assembly Sect, Lab Cellular Imaging & Macromol Biophys, Bethesda, MD USA.
   [Ghirlando, Rodolfo] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD USA.
RP Schuck, P (reprint author), NIBIB, Dynam Macromol Assembly Sect, Lab Cellular Imaging & Macromol Biophys, Bethesda, MD USA.
EM schuckp@mail.nih.gov
OI Schuck, Peter/0000-0002-8859-6966
FU National Institute of Biomedical Imaging and Bioengineering; National
   Institute of Diabetes and Digestive and Kidney Diseases
FX This work was supported by the Intramural Research Program of the
   National Institute of Biomedical Imaging and Bioengineering, and the
   National Institute of Diabetes and Digestive and Kidney Diseases.
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PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
EI 1542-0086
J9 BIOPHYS J
JI Biophys. J.
PD AUG 18
PY 2015
VL 109
IS 4
BP 827
EP 837
DI 10.1016/j.bpj.2015.07.015
PG 11
WC Biophysics
SC Biophysics
GA CP4WA
UT WOS:000359882100018
PM 26287634
ER

PT J
AU Sckisel, GD
   Bouchlaka, MN
   Monjazeb, AM
   Crittenden, M
   Curti, BD
   Wilkins, DEC
   Alderson, KA
   Sungur, CM
   Ames, E
   Mirsoian, A
   Reddy, A
   Alexander, W
   Soulika, A
   Blazar, BR
   Longo, DL
   Wiltrout, RH
   Murphy, WJ
AF Sckisel, Gail D.
   Bouchlaka, Myriam N.
   Monjazeb, Arta M.
   Crittenden, Marka
   Curti, Brendan D.
   Wilkins, Danice E. C.
   Alderson, Kory A.
   Sungur, Can M.
   Ames, Erik
   Mirsoian, Annie
   Reddy, Abhinav
   Alexander, Warren
   Soulika, Athena
   Blazar, Bruce R.
   Longo, Dan L.
   Wiltrout, Robert H.
   Murphy, William J.
TI Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent
   Immunity
SO IMMUNITY
LA English
DT Article
ID PERSISTENT LCMV INFECTION; ANTITUMOR RESPONSES; MEMORY; INTERLEUKIN-2;
   ACTIVATION; INTERFERON; EXPRESSION; BLOCKADE; NAIVE; HELP
AB Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) costimulation, and (3) cytokine-mediated differentiation and expansion. Strong immunostimulatory events such as immunotherapy or infection induce profound cytokine release causing "bystander" T cell activation, thereby increasing the potential for autoreactivity and need for control. We show that during strong stimulation, a profound suppression of primary CD4(+) T-cell-mediated immune responses ensued and was observed across preclinical models and patients undergoing high-dose interleukin-2 (IL-2) therapy. This suppression targeted naive CD4(+) but not CD8(+) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b transcription factor signaling pathway. These events resulted in complete paralysis of primary CD4(+) T cell activation, affecting memory generation and induction of autoimmunity as well as impaired viral clearance. These data highlight the critical regulation of naive CD4(+) T cells during inflammatory conditions.
C1 [Sckisel, Gail D.; Bouchlaka, Myriam N.; Sungur, Can M.; Ames, Erik; Mirsoian, Annie; Reddy, Abhinav; Soulika, Athena; Murphy, William J.] Univ Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA 95817 USA.
   [Monjazeb, Arta M.] Univ Calif Davis, Sch Med, Dept Radiat Oncol, Sacramento, CA 95817 USA.
   [Crittenden, Marka; Curti, Brendan D.] Providence Portland Med Ctr, Robert W Franz Canc Ctr, Earle A Chiles Res Inst, Portland, OR 97213 USA.
   [Crittenden, Marka; Curti, Brendan D.] Oregon Clin, Portland, OR 97220 USA.
   [Wilkins, Danice E. C.; Alderson, Kory A.] Univ Nevada, Reno Sch Med, Dept Microbiol & Immunol, Reno, NV 89557 USA.
   [Alexander, Warren] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia.
   [Soulika, Athena] Shriners Hosp Children Northern Calif, Inst Pediat Regenerat Med, Sacramento, CA 95817 USA.
   [Blazar, Bruce R.] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA.
   [Blazar, Bruce R.] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA.
   [Longo, Dan L.] NIA, Genet Lab, Baltimore, MD 21224 USA.
   [Wiltrout, Robert H.] NCI, Canc & Inflammat Program, Frederick, MD 21702 USA.
   [Murphy, William J.] Univ Calif Davis, Sch Med, Dept Internal Med, Sacramento, CA 95817 USA.
RP Murphy, WJ (reprint author), Univ Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA 95817 USA.
EM wmjmurphy@ucdavis.edu
OI Bouchlaka, Myriam/0000-0003-2865-0817
FU NIH [R01 CA 095572, R01 CA 072669]
FX We would like to thank Monja Metcalf and Weihong Ma for excellent
   technical assistance with these studies. We would also like to thank Dr.
   Jonathan Weiss for helpful discussions with the manuscript. We would
   also like to thank Dr. Fu-Tong Liu for donating his OT-II Tg mouse
   colony, which was further propagated for studies in this manuscript.
   This work was funded by grants from the NIH (R01 CA 095572 and R01 CA
   072669). Samples from patients undergoing systemic high-dose IL-2
   therapy were part of a larger study evaluating combination of
   radiotherapy with systemic IL-2. This trial is supported in part by
   Prometheus Laboratories, Inc.
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PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD AUG 18
PY 2015
VL 43
IS 2
BP 240
EP 250
DI 10.1016/j.immuni.2015.06.023
PG 11
WC Immunology
SC Immunology
GA CP7WW
UT WOS:000360101200008
PM 26231116
ER

PT J
AU Yang, RL
   Qu, CY
   Zhou, Y
   Konkel, JE
   Shi, SH
   Liu, Y
   Chen, CD
   Liu, SY
   Liu, DW
   Chen, YB
   Zandi, E
   Chen, WJ
   Zhou, YH
   Shi, ST
AF Yang, Ruili
   Qu, Cunye
   Zhou, Yu
   Konkel, Joanne E.
   Shi, Shihong
   Liu, Yi
   Chen, Chider
   Liu, Shiyu
   Liu, Dawei
   Chen, Yibu
   Zandi, Ebrahim
   Chen, Wanjun
   Zhou, Yanheng
   Shi, Songtao
TI Hydrogen Sulfide Promotes Tet1-and Tet2-Mediated Foxp3 Demethylation to
   Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis
SO IMMUNITY
LA English
DT Article
ID CYSTATHIONINE-BETA-SYNTHASE; TRANSCRIPTION FACTOR FOXP3; EMBRYONIC
   STEM-CELLS; DNA METHYLATION; GENE-EXPRESSION; TARGET GENES; CIS-ELEMENT;
   MOUSE MODEL; TET2; 5-HYDROXYMETHYLCYTOSINE
AB Regulatory T (Treg) cells are essential for maintenance of immune homeostasis. Here we found that hydrogen sulfide (H2S) was required for Foxp3(+) Treg cell differentiation and function and that H2S deficiency led to systemic autoimmune disease. H2S maintained expression of methylcytosine dioxygenases Tet1 and Tet2 by sulfhydrating nuclear transcription factor Y subunit beta (NFYB) to facilitate its binding to Tet1 and Tet2 promoters. Transforming growth factor-beta (TGF-beta)-activated Smad3 and interleukin-2 (IL-2)-activated Stat5 facilitated Tet1 and Tet2 binding to Foxp3. Tet1 and Tet2 catalyzed conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) in Foxp3 to establish a Treg-cell-specific hypomethylation pattern and stable Foxp3 expression. Consequently, Tet1 and Tet2 deletion led to Foxp3 hypermethylation, impaired Treg cell differentiation and function, and autoimmune disease. Thus, H2S promotes Tet1 and Tet2 expression, which are recruited to Foxp3 by TGF-beta and IL-2 signaling to maintain Foxp3 demethylation and Treg-cell-associated immune homeostasis.
C1 [Yang, Ruili; Liu, Dawei; Zhou, Yanheng] Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China.
   [Yang, Ruili; Chen, Chider; Shi, Songtao] Univ Penn, Sch Dent Med, Dept Anat & Cell Biol, Philadelphia, PA 19104 USA.
   [Yang, Ruili; Qu, Cunye; Shi, Shihong; Chen, Chider; Liu, Shiyu; Shi, Songtao] Univ So Calif, Ostrow Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA.
   [Zhou, Yu; Zandi, Ebrahim] Univ So Calif, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA.
   [Konkel, Joanne E.; Chen, Wanjun] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA.
   [Liu, Yi] Capital Med Univ, Sch Stomatol, Lab Tissue Regenerat & Immunol, Beijing 100050, Peoples R China.
   [Liu, Yi] Capital Med Univ, Sch Stomatol, Dept Periodont, Beijing 100050, Peoples R China.
   [Chen, Yibu] Univ So Calif, Keck Sch Med, Norris Med Lib, Los Angeles, CA 90033 USA.
RP Zhou, YH (reprint author), Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China.
EM yanhengzhou@gmail.com; songtaos@dental.upenn.edu
RI Zhou, Yu/M-7975-2014; Chen, Chider/L-9880-2016
OI Chen, Chider/0000-0003-2899-1208
FU National Institute of Dental and Craniofacial Research, NIH, Department
   of Health and Human Services [R01DE017449, R01DE019932]; Ministry of
   Science and Technology, China [2010DFB32980]; Intramural Research
   Program of NIDCR, NIH
FX This work was supported by grants from the National Institute of Dental
   and Craniofacial Research, NIH, Department of Health and Human Services
   (R01DE017449 and R01DE019932 to Songao Shi), the Ministry of Science and
   Technology, China (2010DFB32980 to Yanheng Zhou), and the Intramural
   Research Program of NIDCR, NIH (for W.C.).
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PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD AUG 18
PY 2015
VL 43
IS 2
BP 251
EP 263
DI 10.1016/j.immuni.2015.07.017
PG 13
WC Immunology
SC Immunology
GA CP7WW
UT WOS:000360101200009
PM 26275994
ER

PT J
AU Bunin, A
   Sisirak, V
   Ghosh, HS
   Grajkowska, LT
   Hou, ZE
   Miron, M
   Yang, C
   Ceribelli, M
   Uetani, N
   Chaperot, L
   Plumas, J
   Hendriks, W
   Tremblay, ML
   Hacker, H
   Staudt, LM
   Green, PH
   Bhagat, G
   Reizis, B
AF Bunin, Anna
   Sisirak, Vanja
   Ghosh, Hiyaa S.
   Grajkowska, Lucja T.
   Hou, Z. Esther
   Miron, Michelle
   Yang, Cliff
   Ceribelli, Michele
   Uetani, Noriko
   Chaperot, Laurence
   Plumas, Joel
   Hendriks, Wiljan
   Tremblay, Michel L.
   Haecker, Hans
   Staudt, Louis M.
   Green, Peter H.
   Bhagat, Govind
   Reizis, Boris
TI Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human
   and Murine Plasmacytoid Dendritic Cells
SO IMMUNITY
LA English
DT Article
ID INTERFERON-PRODUCING CELLS; TRANSCRIPTION FACTOR E2-2; IFN-ALPHA
   PRODUCTION; VIRAL-INFECTION; CPG-DNA; SIGMA; LAR; SUBSETS; AUTOIMMUNITY;
   ACTIVATION
AB Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyrosine phosphatase sigma (PTPRS) is expressed specifically on pDCs. Surface PTPRS was rapidly downregulated after pDC activation, and only PTPRS- pDCs produced IFN-alpha. Antibody-mediated PTPRS crosslinking inhibited pDC activation, whereas PTPRS knockdown enhanced IFN response in a pDC cell line. Similarly, murine Ptprs and the homologous receptor phosphatase Ptprf were specifically co-expressed in murine pDCs. Haplodeficiency or DC-specific deletion of Ptprs on Ptprf-deficient background were associated with enhanced IFN response of pDCs, leukocyte infiltration in the intestine and mild colitis. Thus, PTPRS represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation.
C1 [Bunin, Anna; Sisirak, Vanja; Ghosh, Hiyaa S.; Grajkowska, Lucja T.; Hou, Z. Esther; Miron, Michelle; Yang, Cliff; Reizis, Boris] Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA.
   [Bunin, Anna; Green, Peter H.; Bhagat, Govind] Columbia Univ, Med Ctr, Dept Med, Celiac Dis Ctr, New York, NY 10032 USA.
   [Sisirak, Vanja; Grajkowska, Lucja T.; Reizis, Boris] NYU, Langone Med Ctr, Dept Pathol, New York, NY 10016 USA.
   [Sisirak, Vanja; Grajkowska, Lucja T.; Reizis, Boris] NYU, Langone Med Ctr, Dept Med, New York, NY 10016 USA.
   [Ceribelli, Michele; Staudt, Louis M.] NCI, Lymphoid Malignancy Branch, Ctr Canc Res, Rockville, MD 20852 USA.
   [Uetani, Noriko; Tremblay, Michel L.] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3A 1A3, Canada.
   [Chaperot, Laurence; Plumas, Joel] EFS Rhone Alpes Grenoble, R&D Lab, F-38701 La Tronche, France.
   [Hendriks, Wiljan] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Cell Biol, NL-6525 GA Nijmegen, Netherlands.
   [Haecker, Hans] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA.
   [Bhagat, Govind] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA.
RP Reizis, B (reprint author), Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA.
EM boris.reizis@nyumc.org
RI Hendriks, Wiljan/A-5214-2013; Sisirak, Vanja/O-9393-2016; 
OI Hendriks, Wiljan/0000-0001-9481-8281; Sisirak,
   Vanja/0000-0003-3070-6533; Bhagat, Govind/0000-0001-6250-048X; Reizis,
   Boris/0000-0003-1140-7853
FU NIH [AI072571]; Irvington Institute Fellowship of the Cancer Research
   Institute; American Society of Hematology; NIH training grant [CA009503]
FX We thank Dr. Ivaylo Ivanov for advice, Alexei Kartashov for help with
   statistical analysis, and T. and E. Reizis for help in scoring IRF7
   translocation. Supported by NIH grant AI072571 (B.R.), Irvington
   Institute Fellowship of the Cancer Research Institute (V.S.), American
   Society of Hematology (H.S.G.) and NIH training grant CA009503 (C.Y.).
NR 50
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PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD AUG 18
PY 2015
VL 43
IS 2
BP 277
EP 288
DI 10.1016/j.immuni.2015.07.009
PG 12
WC Immunology
SC Immunology
GA CP7WW
UT WOS:000360101200011
PM 26231120
ER

PT J
AU Horai, R
   Zarate-Blades, CR
   Dillenburg-Pilla, P
   Chen, J
   Kielczewski, JL
   Silver, PB
   Jittayasothorn, Y
   Chan, CC
   Yamane, H
   Honda, K
   Caspi, RR
AF Horai, Reiko
   Zarate-Blades, Carlos R.
   Dillenburg-Pilla, Patricia
   Chen, Jun
   Kielczewski, Jennifer L.
   Silver, Phyllis B.
   Jittayasothorn, Yingyos
   Chan, Chi-Chao
   Yamane, Hidehiro
   Honda, Kenya
   Caspi, Rachel R.
TI Microbiota-Dependent Activation of an Autoreactive T Cell Receptor
   Provokes Autoimmunity in an Immunologically Privileged Site
SO IMMUNITY
LA English
DT Article
ID RETINOID-BINDING PROTEIN; GUT MICROBIOTA; IMMUNE-SYSTEM; DISEASE;
   UVEITIS; TH17; INFLAMMATION; RECOGNITION; EXPRESSION; INDUCTION
AB Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune uveitis, a major cause of human blindness. It is unclear where these autoreactive T cells first become activated, given that their cognate antigens are sequestered within the immune-privileged eye. We demonstrate in a novel mouse model of spontaneous uveitis that activation of retina-specific T cells is dependent on gut commensal microbiota. Retina-specific T cell activation involved signaling through the autoreactive T cell receptor (TCR) in response to non-cognate antigen in the intestine and was independent of the endogenous retinal autoantigen. Our findings not only have implications for the etiology of human uveitis, but also raise the possibility that activation of autoreactive TCRs by commensal microbes might be a more common trigger of autoimmune diseases than is currently appreciated.
C1 [Horai, Reiko; Zarate-Blades, Carlos R.; Chen, Jun; Kielczewski, Jennifer L.; Silver, Phyllis B.; Jittayasothorn, Yingyos; Chan, Chi-Chao; Caspi, Rachel R.] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   [Dillenburg-Pilla, Patricia] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA.
   [Chen, Jun] Sun Yat Sen Univ, State Key Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China.
   [Yamane, Hidehiro] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   [Honda, Kenya] Keio Univ, Sch Med, Tokyo 1608582, Japan.
   [Honda, Kenya] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan.
RP Caspi, RR (reprint author), NEI, Immunol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA.
EM caspir@mail.nih.gov
RI Zarate-Blades, Carlos/C-9663-2015; Honda, Kenya/N-5297-2015; 
OI Zarate-Blades, Carlos/0000-0002-7728-7869; Caspi,
   Rachel/0000-0002-7140-7671
FU NEI intramural funding [EY000184]; CREST, Japan Science and Technology
   Agency (Tokyo, Japan)
FX The authors thank Drs. Koji Atarashi (RIKEN) and Ivan Fuss (NIAID, NIH)
   for sharing protocols, Dr. Kristin Hogquist (University of Minnesota)
   for Nr4a1<SUP>GFP</SUP> reporter mice, Dr. Gregory Liou (Medical College
   of Georgia) for Rbp3<SUP>-/-</SUP> mice, all members of the R.R.C. lab
   for help and advice, NEI Flow Cytometry Core for assistance in cell
   sorting and analysis, NEI Genetic Engineering Core for the assistance in
   antibiotics treatment and mouse colony maintenance, NEI Histology Core
   for processing of histology specimens, and NIH-DVR Pathology and
   Bacteriology labs for bacteriological analysis. We thank Drs. Silvio
   Gutkind (NIDCR), William E. Paul (NIAID), Katsuko Sudo (Tokyo Medical
   University), and Kikuji Itoh (Japan SLC) for support and useful
   discussions. R.R.C. is supported by NEI intramural funding (project #
   EY000184) and K.H. is supported by CREST, Japan Science and Technology
   Agency (Tokyo, Japan).
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PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD AUG 18
PY 2015
VL 43
IS 2
BP 343
EP 353
DI 10.1016/j.immuni.2015.07.014
PG 11
WC Immunology
SC Immunology
GA CP7WW
UT WOS:000360101200016
PM 26287682
ER

PT J
AU Califano, D
   Cho, JJ
   Uddin, MN
   Lorentsen, KJ
   Yang, Q
   Bhandoola, A
   Li, HM
   Avram, D
AF Califano, Danielle
   Cho, Jonathan J.
   Uddin, Mohammad N.
   Lorentsen, Kyle J.
   Yang, Qi
   Bhandoola, Avinash
   Li, Hongmin
   Avram, Dorina
TI Transcription Factor Bcl11b Controls Identity and Function of Mature
   Type 2 Innate Lymphoid Cells
SO IMMUNITY
LA English
DT Article
ID DOUBLE-POSITIVE THYMOCYTES; ROR-GAMMA-T; INTESTINAL INFLAMMATION;
   ALLERGIC INFLAMMATION; COMMENSAL BACTERIA; REGULATORY CELLS; FACTOR
   GATA3; LYMPHOCYTES; NOTCH; SPECIFICATION
AB Type 2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Here, we report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature ILC2s. Consequently, Bcl11b(-/-) ILC2s downregulated Gata3 and downstream genes, including Il1rl1 (encoding IL-33 receptor), and upregulated Rorc and type 3 ILC (ILC3) genes. Additionally, independent of Gfi1, Bcl11b directly repressed expression of the gene encoding the ILC3 transcription factor Ahr, further contributing to silencing of ILC3 genes in ILC2s. Thus, Bcl11b(-/-) ILC2s lost their functions and gained ILC3 functions, and although they expanded in response to the protease allergen papain, they produced ILC3 but not ILC2 cytokines and caused increased airway infiltration of neutrophils instead of eosinophils. Our results demonstrate that Bcl11b is more than just a T-cell-only transcription factor and establish that Bcl11b sustains mature ILC2 genetic and functional programs and lineage fidelity.
C1 [Califano, Danielle; Cho, Jonathan J.; Uddin, Mohammad N.; Lorentsen, Kyle J.; Avram, Dorina] Albany Med Ctr, Ctr Immunol & Microbial Dis, Albany, NY 12208 USA.
   [Cho, Jonathan J.; Uddin, Mohammad N.; Lorentsen, Kyle J.; Avram, Dorina] Univ Florida, Dept Med, Coll Med, Gainesville, FL 32610 USA.
   [Yang, Qi] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
   [Bhandoola, Avinash] NCI, T Cell Biol & Dev Sect, Lab Genome Integr, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
   [Li, Hongmin] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA.
RP Avram, D (reprint author), Albany Med Ctr, Ctr Immunol & Microbial Dis, 47 New Scotland Ave,MC 165, Albany, NY 12208 USA.
EM dorina.avram@medicine.ufl.edu
FU NIH [RO1AI067846, R21AI112492]; University of Florida startup funds
FX We greatly acknowledge Drs. Kate MacNamara, Jon Harton, and Bill
   O'Connor (Albany Medical College) for valuable suggestions and exciting
   discussions. We further acknowledge Dr. Renjie Song (Wadsworth Center)
   for assistance with cell sorting. We greatly acknowledge Dr. Douglas
   Cohn, Ms. Victoria Boppert, and Ms. Hattie Wang for care of the mice.
   Financial support was provided by NIH grants RO1AI067846 and R21AI112492
   and by University of Florida startup funds to Dorina Avram.
NR 46
TC 21
Z9 21
U1 1
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD AUG 18
PY 2015
VL 43
IS 2
BP 354
EP 368
DI 10.1016/j.immuni.2015.07.005
PG 15
WC Immunology
SC Immunology
GA CP7WW
UT WOS:000360101200017
PM 26231117
ER

PT J
AU Bittner, V
   Bertolet, M
   Felix, RB
   Farkouh, ME
   Goldberg, S
   Ramanathan, KB
   Redmon, JB
   Sperling, L
   Rutter, MK
AF Bittner, Vera
   Bertolet, Marnie
   Felix, Rafael Barraza
   Farkouh, Michael E.
   Goldberg, Suzanne
   Ramanathan, Kodangudi B.
   Redmon, J. Bruce
   Sperling, Laurence
   Rutter, Martin K.
CA BARI 2D Study Grp
TI Comprehensive Cardiovascular Risk Factor Control Improves Survival The
   BARI 2D Trial
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE blood pressure; cholesterol; coronary heart disease; diabetes mellitus;
   glycosylated hemoglobin A; smoking
ID BLOOD-PRESSURE; MULTIFACTORIAL INTERVENTION; CORONARY-DISEASE; OUTCOMES;
   REVASCULARIZATION
AB BACKGROUND It is unclear whether achieving multiple risk factor (RF) goals through protocol-guided intensive medical therapy is feasible or improves outcomes in type 2 diabetes mellitus.
   OBJECTIVES This study sought to quantify the relationship between achieved RF goals in the BARI 2D (Bypass Angioplasty Investigation Revascularization 2 Diabetes) trial and cardiovascular events/survival.
   METHODS We performed a nonrandomized analysis of survival/cardiovascular events and control of 6 RFs (no smoking, non-high-density lipoprotein cholesterol <130 mg/dl, triglycerides <150 mg/dl, blood pressure [systolic <130 mm Hg; diastolic <80 mm Hg], glycosylated hemoglobin <7%) in BARI 2D. Cox models with time-varying number of RFs in control were adjusted for baseline number of RFs in control, clinical characteristics, and trial randomization assignments.
   RESULTS In 2,265 patients (mean age 62 years, 29% women) followed up for 5 years, the mean +/- SD number of RFs in control improved from 3.5 perpendicular to 1.4 at baseline to 4.2 perpendicular to 1.3 at 5 years (p <0.0001). The number of RFs in control during the trial was strongly related to death (global p = 0.0010) and the composite of death, myocardial infarction, and stroke (global p = 0.0035) in fully adjusted models. Participants with 0 to 2 RFs in control during follow-up had a 2-fold higher risk of death (hazard ratio: 2.0; 95% confidence interval: 1.3 to 3.3; p = 0.0031) and a 1.7-fold higher risk of the composite endpoint (hazard ratio: 1.7; 95% confidence interval: 1.2 to 2.5; p = 0.0043), compared with those with 6 RFs in control.
   CONCLUSIONS Simultaneous control of multiple RFs through protocol-guided intensive medical therapy is feasible and relates to cardiovascular morbidity and mortality in patients with coronary disease and type 2 diabetes mellitus. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes [BARI 2D]; NCT00006305) (J Am Coll Cardiol 2015; 66: 765-73) (C) 2015 by the American College of Cardiology Foundation.
C1 [Bittner, Vera] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA.
   [Bertolet, Marnie] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Felix, Rafael Barraza] Mexican Inst Social Secur, Mexico City, DF, Mexico.
   [Farkouh, Michael E.] Mt Sinai Sch Med, New York, NY USA.
   [Goldberg, Suzanne] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Ramanathan, Kodangudi B.] VA Med Ctr Memphis, Memphis, TN USA.
   [Redmon, J. Bruce] Univ Minnesota, Dept Med & Urol Surg, Minneapolis, MN USA.
   [Sperling, Laurence] Emory Univ, Atlanta, GA 30322 USA.
   [Rutter, Martin K.] Univ Manchester, Inst Human Dev, Fac Med & Human Sci, Endocrinol & Diabet Res Grp, Manchester, Lancs, England.
   [Rutter, Martin K.] Manchester Acad Hlth Sci Ctr, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Diabet Ctr, Manchester, Lancs, England.
RP Bittner, V (reprint author), Univ Alabama Birmingham, 701 19th St South,LHRB 310, Birmingham, AL 35294 USA.
EM vbittner@uab.edu
OI Bertolet, Marnie/0000-0002-5799-9033; Rutter, Martin/0000-0001-6380-539X
FU NHLBI NIH HHS [R21 HL121495, U01 HL061744, U01 HL061746, U01 HL061748,
   U01 HL063804]
NR 14
TC 24
Z9 24
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD AUG 18
PY 2015
VL 66
IS 7
BP 765
EP 773
DI 10.1016/j.jacc.2015.06.019
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA CP5VK
UT WOS:000359952900001
PM 26271057
ER

PT J
AU Khan, W
   Aguilar, C
   Kiddle, SJ
   Doyle, O
   Thambisetty, M
   Muehlboeck, S
   Sattlecker, M
   Newhouse, S
   Lovestone, S
   Dobson, R
   Giampietro, V
   Westman, E
   Simmons, A
AF Khan, Wasim
   Aguilar, Carlos
   Kiddle, Steven J.
   Doyle, Orla
   Thambisetty, Madhav
   Muehlboeck, Sebastian
   Sattlecker, Martina
   Newhouse, Stephen
   Lovestone, Simon
   Dobson, Richard
   Giampietro, Vincent
   Westman, Eric
   Simmons, Andrew
CA Alzheimer's Dis Neuroimaging Initi
TI A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel
   Associated with Brain Atrophy, Disease Classification and Prediction in
   Alzheimer's Disease
SO PLOS ONE
LA English
DT Article
ID MILD COGNITIVE IMPAIRMENT; NEUROIMAGING INITIATIVE SUBJECTS;
   ACID-BINDING PROTEIN; CHROMOGRANIN-A; CSF BIOMARKERS; OLDER-ADULTS; MCI
   PATIENTS; MRI MEASURES; PATTERNS; NEURODEGENERATION
AB In this exploratory neuroimaging-proteomic study, we aimed to identify CSF proteins associated with AD and test their prognostic ability for disease classification and MCI to AD conversion prediction. Our study sample consisted of 295 subjects with CSF multi-analyte panel data and MRI at baseline downloaded from ADNI. Firstly, we tested the statistical effects of CSF proteins (n = 83) to measures of brain atrophy, CSF biomarkers, ApoE genotype and cognitive decline. We found that several proteins (primarily CgA and FABP) were related to either brain atrophy or CSF biomarkers. In relation to ApoE genotype, a unique biochemical profile characterised by low CSF levels of Apo E was evident in epsilon 4 carriers compared to epsilon 3 carriers. In an exploratory analysis, 3/83 proteins (SGOT, MCP-1, IL6r) were also found to be mildly associated with cognitive decline in MCI subjects over a 4-year period. Future studies are warranted to establish the validity of these proteins as prognostic factors for cognitive decline. For disease classification, a subset of proteins (n = 24) combined with MRI measurements and CSF biomarkers achieved an accuracy of 95.1% (Sensitivity 87.7%; Specificity 94.3%; AUC 0.95) and accurately detected 94.1% of MCI subjects progressing to AD at 12 months. The subset of proteins included FABP, CgA, MMP-2, and PPP as strong predictors in the model. Our findings suggest that the marker of panel of proteins identified here may be important candidates for improving the earlier detection of AD. Further targeted proteomic and longitudinal studies would be required to validate these findings with more generalisability.
C1 [Khan, Wasim; Kiddle, Steven J.; Doyle, Orla; Muehlboeck, Sebastian; Sattlecker, Martina; Newhouse, Stephen; Dobson, Richard; Giampietro, Vincent; Westman, Eric; Simmons, Andrew] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Khan, Wasim; Kiddle, Steven J.; Muehlboeck, Sebastian; Sattlecker, Martina; Newhouse, Stephen; Dobson, Richard; Simmons, Andrew] NIHR Biomed Res Ctr Mental Hlth, London, England.
   [Khan, Wasim; Muehlboeck, Sebastian; Dobson, Richard; Simmons, Andrew] NIHR Biomed Res Unit Dementia, London, England.
   [Aguilar, Carlos; Westman, Eric] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Thambisetty, Madhav] NIA, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Lovestone, Simon] Univ Oxford, Dept Psychiat, Oxford, England.
RP Khan, W (reprint author), Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
EM wasim.khan@kcl.ac.uk
RI Simmons, Andrew/B-8848-2008; Westman, Eric/H-5771-2011; Giampietro,
   Vincent/D-1279-2011; 
OI Simmons, Andrew/0000-0003-2306-5811; Giampietro,
   Vincent/0000-0002-9381-8201; Doyle, Orla/0000-0002-6964-0140; Kiddle,
   Steven/0000-0003-4350-7437; Westman, Eric/0000-0002-3115-2977
FU ADNI from National Institutes of Health [U01 393 AG024904]; NIHR
   Biomedical Research Centre for Mental Health; NIHR Biomedical Research
   Unit for Dementia at the South London and Maudsley NHS Foundation Trust;
   Institute of Psychiatry, Kings College London; Alzheimer's Research UK;
   National Institutes of Health [P30 AG010129, K01 AG030514]; Dana
   Foundation
FX Data collection and sharing for this project were funded by the ADNI
   (grant U01 393 AG024904 from the National Institutes of Health). This
   study was supported by funds from the NIHR Biomedical Research Centre
   for Mental Health and NIHR Biomedical Research Unit for Dementia at the
   South London and Maudsley NHS Foundation Trust and Institute of
   Psychiatry, Kings College London, and Alzheimer's Research UK. This
   research was also supported by grants P30 AG010129 and K01 AG030514 from
   the National Institutes of Health and by the Dana Foundation.
NR 48
TC 2
Z9 2
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 18
PY 2015
VL 10
IS 8
AR e0134368
DI 10.1371/journal.pone.0134368
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP1VY
UT WOS:000359666100009
PM 26284520
ER

PT J
AU Sun, Y
   Liu, CH
   SanGiovanni, JP
   Evans, LP
   Tian, KT
   Zhang, B
   Stahl, A
   Pu, WT
   Kamenecka, TM
   Solt, LA
   Chen, J
AF Sun, Ye
   Liu, Chi-Hsiu
   SanGiovanni, John Paul
   Evans, Lucy P.
   Tian, Katherine T.
   Zhang, Bing
   Stahl, Andreas
   Pu, William T.
   Kamenecka, Theodore M.
   Solt, Laura A.
   Chen, Jing
TI Nuclear receptor ROR alpha regulates pathologic retinal angiogenesis by
   modulating SOCS3-dependent inflammation
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE ROR alpha; neovascularization; retinopathy; inflammation; SOCS3
ID PROLIFERATIVE DIABETIC-RETINOPATHY; LIGAND-BINDING DOMAIN; MOUSE MODEL;
   ORPHAN; NEOVASCULARIZATION; CELLS; GENE; MICE; INTERLEUKIN-1-BETA;
   DIFFERENTIATION
AB Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor-related orphan receptor alpha (ROR alpha) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism and inflammation; however, its role in pathologic retinal angiogenesis remains poorly understood. Using a mouse model of oxygen-induced proliferative retinopathy, we showed that ROR alpha expression was significantly increased and genetic deficiency of ROR alpha substantially suppressed pathologic retinal neovascularization. Loss of ROR alpha led to decreased levels of proinflammatory cytokines and increased levels of antiinflammatory cytokines in retinopathy. ROR alpha directly suppressed the gene transcription of suppressors of cytokine signaling 3 (SOCS3), a critical negative regulator of inflammation. Inhibition of SOCS3 abolished the antiinflammatory and vasoprotective effects of ROR alpha deficiency in vitro and in vivo. Moreover, treatment with a ROR alpha inverse agonist SR1001 effectively protected against pathologic neovascularization in both oxygen-induced retinopathy and another angiogenic model of very-low-density lipoprotein receptor (Vldlr)-deficient (Vldlr(-/-)) mice with spontaneous subretinal neovascularization, whereas a ROR alpha agonist worsened oxygen-induced retinopathy. Our data demonstrate that ROR alpha is a novel regulator of pathologic retinal neovascularization, and ROR alpha inhibition may represent a new way to treat ocular neovascularization.
C1 [Sun, Ye; Liu, Chi-Hsiu; Evans, Lucy P.; Tian, Katherine T.; Chen, Jing] Harvard Univ, Boston Childrens Hosp, Dept Ophthalmol, Sch Med, Boston, MA 02115 USA.
   [SanGiovanni, John Paul] NIAAA, Sect Nutr Neurosci, Bethesda, MD 20892 USA.
   [Zhang, Bing; Pu, William T.] Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA.
   [Stahl, Andreas] Univ Freiburg, Ctr Eye, D-79106 Freiburg, Germany.
   [Kamenecka, Theodore M.; Solt, Laura A.] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA.
RP Chen, J (reprint author), Harvard Univ, Boston Childrens Hosp, Dept Ophthalmol, Sch Med, Boston, MA 02115 USA.
EM jing.chen@childrens.harvard.edu
FU NIH/National Eye Institute [R01 EY024963]; BrightFocus Foundation;
   Boston Children's Hospital (BCH) Career Development Award; BCH
   Ophthalmology Foundation; Massachusetts Lions Eye Research Fund Inc.;
   Alcon Research Institute; Deutsche Forschungsgemeinschaft [DFG STA
   1102/5-1]; Deutsche Ophthalmologische Gesellschaft
FX We thank Drs. Lois Smith, Thomas Burris, Przemyslaw Sapieha, and Zhuo
   Shao for expert advice and/or critical review of the manuscript; Aimee
   Juan, Dorothy Pei, Ricky Cui, Christian Hurst, and Roberta Dennison for
   technical assistance; Drs. Xi He and Xinjun Zhang for providing
   reagents; and Drs. Martin Friedlander, Edith Aguilar, and Yoshihiko Usui
   for providing CX3CR1-GFP retinas. This work was supported by
   NIH/National Eye Institute (R01 EY024963), BrightFocus Foundation,
   Boston Children's Hospital (BCH) Career Development Award, BCH
   Ophthalmology Foundation, Massachusetts Lions Eye Research Fund Inc.,
   and Alcon Research Institute (J.C.). A.S. was supported by Deutsche
   Forschungsgemeinschaft (DFG STA 1102/5-1) and Deutsche Ophthalmologische
   Gesellschaft.
NR 42
TC 4
Z9 5
U1 1
U2 6
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 18
PY 2015
VL 112
IS 33
BP 10401
EP 10406
DI 10.1073/pnas.1504387112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2WL
UT WOS:000359738300074
PM 26243880
ER

PT J
AU Cho, KJ
   Walseng, E
   Ishido, S
   Roche, PA
AF Cho, Kyung-Jin
   Walseng, Even
   Ishido, Satoshi
   Roche, Paul A.
TI Ubiquitination by March-I prevents MHC class II recycling and promotes
   MHC class II turnover in antigen-presenting cells
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE MHC class II; antigen processing and presentation; ubiquitination;
   recycling; March-I
ID DENDRITIC CELLS; PEPTIDE COMPLEXES; PLASMA-MEMBRANE; B-CELLS; TRANSPORT;
   DEGRADATION; MATURATION; SURFACE; GLYCOPROTEINS; ENDOCYTOSIS
AB MHC class II (MHC-II)-dependent antigen presentation by antigen-presenting cells (APCs) is carefully controlled to achieve specificity of immune responses; the regulated assembly and degradation of antigenic peptide-MHC-II complexes (pMHC-II) is one aspect of such control. In this study, we have examined the role of ubiquitination in regulating pMHC-II biosynthesis, endocytosis, recycling, and turnover in APCs. By using APCs obtained from MHC-II ubiquitination mutant mice, we find that whereas ubiquitination does not affect pMHC-II formation in dendritic cells (DCs), it does promote the subsequent degradation of newly synthesized pMHC-II. Acute activation of DCs or B cells terminates expression of the MHC-II E3 ubiquitin ligase March-I and prevents pMHC-II ubiquitination. Most importantly, this change results in very efficient pMHC-II recycling from the surface of DCs and B cells, thereby preventing targeting of internalized pMHC-II to lysosomes for degradation. Biochemical and functional assays confirmed that pMHC-II turnover is suppressed in MHC-II ubiquitin mutant DCs or by acute activation of wild-type DCs. These studies demonstrate that acute APC activation blocks the ubiquitin-dependent turnover of pMHC-II by promoting efficient pMHC-II recycling and preventing lysosomal targeting of internalized pMHC-II, thereby enhancing pMHC-II stability for efficient antigen presentation to CD4 T cells.
C1 [Cho, Kyung-Jin; Walseng, Even; Roche, Paul A.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
   [Ishido, Satoshi] Showa Pharmaceut Univ, Lab Integrat Infect Immun, Machida, Tokyo 1948543, Japan.
RP Roche, PA (reprint author), NCI, Expt Immunol Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.
EM paul.roche@nih.gov
FU Intramural Research Program of the National Institutes of Health;
   Ministry of Education, Culture, Sports, Science and Technology; Japan
   Society for the Promotion of Science
FX This work was supported by the Intramural Research Program of the
   National Institutes of Health (to P.A.R.); the Ministry of Education,
   Culture, Sports, Science and Technology (to S.I.); and the Japan Society
   for the Promotion of Science (to S.I.).
NR 36
TC 8
Z9 8
U1 3
U2 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 18
PY 2015
VL 112
IS 33
BP 10449
EP 10454
DI 10.1073/pnas.1507981112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2WL
UT WOS:000359738300082
PM 26240324
ER

PT J
AU Fedeles, BI
   Freudenthal, BD
   Yau, E
   Singh, V
   Chang, SC
   Li, DY
   Delaney, JC
   Wilson, SH
   Essigmann, JM
AF Fedeles, Bogdan I.
   Freudenthal, Bret D.
   Yau, Emily
   Singh, Vipender
   Chang, Shiou-chi
   Li, Deyu
   Delaney, James C.
   Wilson, Samuel H.
   Essigmann, John M.
TI Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic
   connection between chronic inflammation and cancer
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE 5-chloro-deoxycytidine; hypochlorite; myeloperoxidase; inflammatory
   bowel disease; carcinogenesis
ID DNA-POLYMERASE-BETA; TEMPLATING 8-OXOGUANINE LESION; HYPOCHLOROUS ACID;
   CYTOSINE METHYLATION; MUTATIONAL PROCESSES; SOMATIC MUTATIONS;
   ESCHERICHIA-COLI; CPG DINUCLEOTIDE; ACTIVE-SITE; IN-VIVO
AB During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a mutagenic outcome within the cell. The present work shows that 5ClC is intrinsically mutagenic, both in vitro and, at a level of a single molecule per cell, in vivo. Using biochemical and genetic approaches, we have quantified the mutagenic and toxic properties of 5ClC, showing that this lesion caused C -> T transitions at frequencies ranging from 3-9% depending on the polymerase traversing the lesion. X-ray crystallographic studies provided a molecular basis for the mutagenicity of 5ClC; a snapshot of human polymerase beta replicating across a primed 5ClC-containing template uncovered 5ClC engaged in a nascent base pair with an incoming dATP analog. Accommodation of the chlorine substituent in the template major groove enabled a unique interaction between 5ClC and the incoming dATP, which would facilitate mutagenic lesion bypass. The type of mutation induced by 5ClC, the C -> T transition, has been previously shown to occur in substantial amounts both in tissues under inflammatory stress and in the genomes of many inflammation-associated cancers. In fact, many sequence-specific mutational signatures uncovered in sequenced cancer genomes feature C -> T mutations. Therefore, the mutagenic ability of 5ClC documented in the present study may constitute a direct functional link between chronic inflammation and the genetic changes that enable and promote malignant transformation.
C1 [Fedeles, Bogdan I.; Singh, Vipender; Li, Deyu; Delaney, James C.; Essigmann, John M.] MIT, Dept Chem, Cambridge, MA 02139 USA.
   [Fedeles, Bogdan I.; Yau, Emily; Singh, Vipender; Chang, Shiou-chi; Li, Deyu; Delaney, James C.; Essigmann, John M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA.
   [Fedeles, Bogdan I.; Yau, Emily; Singh, Vipender; Chang, Shiou-chi; Li, Deyu; Delaney, James C.; Essigmann, John M.] MIT, Ctr Environm Hlth Sci, Cambridge, MA 02139 USA.
   [Freudenthal, Bret D.; Wilson, Samuel H.] NIEHS, Genome Integr & Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Essigmann, JM (reprint author), MIT, Dept Chem, Cambridge, MA 02139 USA.
EM jessig@mit.edu
OI Chang, Shiou-chi/0000-0002-2494-7763
FU NIH [P01 CA26731, R37 CA080024]; NIH Center [P30 ES002109]; NIH,
   National Institute of Environmental Health Sciences [Z01-ES050158]
FX We thank Allison Simi, Maria Kulikova, and Nicole Zatorski for their
   assistance; Koli Taghizadeh for technical advice; and Charles Knutson,
   Steven Tannenbaum, and Gerald Wogan for valuable feedback on the
   manuscript. We also thank the MIT Center for Environmental Health
   Sciences (MIT CEHS) for providing access to the Instrumentation Core
   facility. This work was supported by NIH Grants P01 CA26731 and R37
   CA080024 (both to J.M.E), NIH Center Grant P30 ES002109 (to the MIT
   CEHS), and by the Intramural Research Program of the NIH, National
   Institute of Environmental Health Sciences, Project Nos. Z01-ES050158
   (S.H.W.).
NR 65
TC 8
Z9 8
U1 2
U2 15
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 18
PY 2015
VL 112
IS 33
BP E4571
EP E4580
DI 10.1073/pnas.1507709112
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2WL
UT WOS:000359738300010
PM 26243878
ER

PT J
AU Moon, AF
   Gosavi, RA
   Kunkel, TA
   Pedersen, LC
   Bebenek, K
AF Moon, Andrea F.
   Gosavi, Rajendrakumar A.
   Kunkel, Thomas A.
   Pedersen, Lars C.
   Bebenek, Katarzyna
TI Creative template-dependent synthesis by human polymerase mu
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE DNA polymerase mu; DNA polymerase lambda; DNA repair; nonhomologous end
   joining
ID HUMAN DNA-POLYMERASE; GAP-FILLING SYNTHESIS; BREAK REPAIR; POL-MU;
   LAMBDA; STRAND; FIDELITY; BETA; POLYMERIZATION; COMPLEXES
AB Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol. and Pol ae. Which of these two polymerases is preferentially used for filling DNA gaps during NHEJ partly depends on sequence complementarity at the break, with Pol lambda and Pol mu repairing complementary and noncomplementary ends, respectively. To better understand these substrate preferences, we present crystal structures of Pol mu on a 2-nt gapped DNA substrate, representing three steps of the catalytic cycle. In striking contrast to Pol lambda, Pol mu "skips" the first available template nucleotide, instead using the template base at the 5' end of the gap to direct nucleotide binding and incorporation. This remarkable divergence from canonical 3'-end gap filling is consistent with data on end-joining substrate specificity in cells, and provides insights into polymerase substrate choices during NHEJ.
C1 [Moon, Andrea F.; Gosavi, Rajendrakumar A.; Kunkel, Thomas A.; Pedersen, Lars C.; Bebenek, Katarzyna] NIEHS, Genome Integr & Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Pedersen, LC (reprint author), NIEHS, Genome Integr & Struct Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM pederse2@niehs.nih.gov
FU Division of Intramural Research of the National Institute of
   Environmental Health Sciences, National Institutes of Health [1ZIA
   ES102645-03, Z01 ES065070]
FX We thank R. Williams and W. Beard for critical reading of the
   manuscript. This research was supported by Division of Intramural
   Research of the National Institute of Environmental Health Sciences,
   National Institutes of Health Grants 1ZIA ES102645-03 (to L.C.P.) and
   Z01 ES065070 (to T.A.K.).
NR 38
TC 2
Z9 2
U1 0
U2 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 18
PY 2015
VL 112
IS 33
BP E4530
EP E4536
DI 10.1073/pnas.1505798112
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP2WL
UT WOS:000359738300005
PM 26240373
ER

PT J
AU Khan, SY
   Ali, S
   Naeem, MA
   Khan, SN
   Husnain, T
   Butt, NH
   Qazi, ZA
   Akram, J
   Riazuddin, S
   Ayyagari, R
   Hejtmancik, JF
   Riazuddin, SA
AF Khan, Shahid Y.
   Ali, Shahbaz
   Naeem, Muhammad Asif
   Khan, Shaheen N.
   Husnain, Tayyab
   Butt, Nadeem H.
   Qazi, Zaheeruddin A.
   Akram, Javed
   Riazuddin, Sheikh
   Ayyagari, Radha
   Hejtmancik, J. Fielding
   Riazuddin, S. Amer
TI Splice-site mutations identified in PDE6A responsible for retinitis
   pigmentosa in consanguineous Pakistani families
SO MOLECULAR VISION
LA English
DT Article
ID PHOSPHODIESTERASE ALPHA-SUBUNIT; ROD CGMP-PHOSPHODIESTERASE; GATED
   CHANNEL; HUMAN GENE; PHOTORECEPTOR; DISEASES; DNA; DYSTROPHIES; MICE
AB Purpose: This study was conducted to localize and identify causal mutations associated with autosomal recessive retinitis pigmentosa (RP) in consanguineous familial cases of Pakistani origin.
   Methods: Ophthalmic examinations that included funduscopy and electroretinography (ERG) were performed to confirm the affectation status. Blood samples were collected from all participating individuals, and genomic DNA was extracted. A genome-wide scan was performed, and two-point logarithm of odds (LOD) scores were calculated. Sanger sequencing was performed to identify the causative variants. Subsequently, we performed whole exome sequencing to rule out the possibility of a second causal variant within the linkage interval. Sequence conservation was performed with alignment analyses of PDE6A orthologs, and in silico splicing analysis was completed with Human Splicing Finder version 2.4.1.
   Results: A large multigenerational consanguineous family diagnosed with early-onset RP was ascertained. An ophthalmic clinical examination consisting of fundus photography and electroretinography confirmed the diagnosis of RP. A genome-wide scan was performed, and suggestive two-point LOD scores were observed with markers on chromosome 5q. Haplotype analyses identified the region; however, the region did not segregate with the disease phenotype in the family. Subsequently, we performed a second genome-wide scan that excluded the entire genome except the chromosome 5q region harboring PDE6A. Next-generation whole exome sequencing identified a splice acceptor site mutation in intron 16: c.2028-1G>A, which was completely conserved in PDE6A orthologs and was absent in ethnically matched 350 control chromosomes, the 1000 Genomes database, and the NHLBI Exome Sequencing Project. Subsequently, we investigated our entire cohort of RP familial cases and identified a second family who harbored a splice acceptor site mutation in intron 10: c.1408-2A>G. In silico analysis suggested that these mutations will result in the elimination of wild-type splice acceptor sites that would result in either skipping of the respective exon or the creation of a new cryptic splice acceptor site; both possibilities would result in retinal photoreceptor cells that lack PDE6A wild-type protein.
   Conclusions: we report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal symptoms of RP. Taken together with our previously published work, our data suggest that mutations in PDE6A account for about 2% of the total genetic load of RP in our cohort and possibly in the Pakistani population as well.
C1 [Khan, Shahid Y.; Riazuddin, S. Amer] Johns Hopkins Univ Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA.
   [Ali, Shahbaz; Naeem, Muhammad Asif; Khan, Shaheen N.; Husnain, Tayyab; Riazuddin, Sheikh] Univ Punjab, Natl Ctr Excellence Mol Biol, Lahore, Pakistan.
   [Butt, Nadeem H.; Akram, Javed; Riazuddin, Sheikh] Univ Hlth Sci, Allama Iqbal Med Coll, Lahore, Pakistan.
   [Qazi, Zaheeruddin A.] Layton Rahmatulla Benevolent Trust Hosp, Lahore, Pakistan.
   [Akram, Javed; Riazuddin, Sheikh] Shaheed Zulfiqar Ali Bhutto Med Univ, Natl Ctr Genet Dis, Islamabad, Pakistan.
   [Ayyagari, Radha] Univ Calif San Diego, Shiley Eye Inst, La Jolla, CA 92093 USA.
   [Hejtmancik, J. Fielding] NEI, Ophthalm Genet & Visual Funct Branch, NIH, Bethesda, MD 20892 USA.
RP Riazuddin, SA (reprint author), Johns Hopkins Univ Sch Med, Wilmer Eye Inst, 600 N Wolfe St,Maumenee 840, Baltimore, MD 21287 USA.
EM riazuddin@jhmi.edu
FU Higher Education Commission (HEC), Islamabad Pakistan; Ministry of
   Science and Technology, Islamabad, Pakistan; National Eye Institute
   [R01EY021237-01]
FX We are thankful to all family members for their participation in this
   study. This study was supported in part by Higher Education Commission
   (HEC), Islamabad Pakistan and Ministry of Science and Technology,
   Islamabad, Pakistan, and by the National Eye Institute Grant
   R01EY021237-01 (RA and SAR).
NR 26
TC 1
Z9 1
U1 2
U2 4
PU MOLECULAR VISION
PI ATLANTA
PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E,
   ATLANTA, GA 30322 USA
SN 1090-0535
J9 MOL VIS
JI Mol. Vis.
PD AUG 18
PY 2015
VL 21
BP 871
EP 882
PG 12
WC Biochemistry & Molecular Biology; Ophthalmology
SC Biochemistry & Molecular Biology; Ophthalmology
GA CP1KS
UT WOS:000359635300002
PM 26321862
ER

PT J
AU Huang, ZH
   Myhr, C
   Bathgate, RAD
   Ho, BA
   Bueno, A
   Hu, X
   Xiao, JB
   Southall, N
   Barnaeva, E
   Agoulnik, IU
   Marugan, JJ
   Ferrer, M
   Agoulnik, AI
AF Huang, Zaohua
   Myhr, Courtney
   Bathgate, Ross A. D.
   Ho, Brian A.
   Bueno, Amaya
   Hu, Xin
   Xiao, Jingbo
   Southall, Noel
   Barnaeva, Elena
   Agoulnik, Irina U.
   Marugan, Juan J.
   Ferrer, Marc
   Agoulnik, Alexander I.
TI Activation of relaxin family receptor 1 from different mammalian species
   by relaxin peptide and small-molecule agonist ML290
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE relaxin; G protein-coupled receptor; RXFP1; receptor structure-function;
   small-molecule allosteric agonist
ID PROTEIN-COUPLED RECEPTOR-7; LEUCINE-RICH REPEAT; RABBIT PLACENTAL
   RELAXIN; CLASS-A MODULE; SPLICE VARIANTS; PHYSIOLOGICAL ROLES;
   IDENTIFICATION; RXFP1; HORMONE; GENE
AB Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial. We have identified a small-molecule agonist of human RXFP1, ML290; however, it does not activate the mouse receptor. To find a suitable animal model for ML290 testing and to gain mechanistic insights into the interaction of various ligands with RXFP1, we have cloned rhesus macaque, pig, rabbit, and guinea pig RXFP1s and analyzed their activation by RLN and ML290. HEK293T cells expressing macaque or pig RXFP1 responded to relaxin and ML290 treatment as measured by an increase of cAMP production. Guinea pig RXFP1 responded to relaxin but had very low response to ML290 treatment only at highest concentrations used. The rabbit RXFP1 amino acid sequence was the most divergent, with a number of unique substitutions within the ectodomain and the seven-transmembrane domain (7TM). Two splice variants of rabbit RXFP1 derived through alternative splicing of the fourth exon were identified. In contrast to the other species, rabbit RXFP1s were activated by ML290, but not with human, pig, mouse, or rabbit RLNs. Using FLAG-tagged constructs, we have shown that both rabbit RXFP1 variants are expressed on the cell surface. No binding of human Eu-labeled RLN to rabbit RXFP1 was detected, suggesting that in this species, RXFP1 might be non-functional. We used chimeric rabbit human and guinea pig human constructs to identify regions important for RLN or ML290 receptor activation. Chimeras with the human ectodomain and rabbit 7TM domain were activated by RLN, whereas substitution of part of the guinea pig 7TM domain with the human sequence only partially restored ML290 activation, confirming the allosteric mode of action for the two ligands. Our data demonstrate that macaque and pig models can be used for ML290 testing.
C1 [Huang, Zaohua; Myhr, Courtney; Ho, Brian A.; Bueno, Amaya; Agoulnik, Alexander I.] Florida Int Univ, Herbert Wertheim Coll Med, Dept Human & Mol Genet, 11200 SW 8th St,AHCI 419B, Miami, FL 33199 USA.
   [Bathgate, Ross A. D.] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Dept Biochem & Mol Biol, Melbourne, Vic, Australia.
   [Hu, Xin; Xiao, Jingbo; Southall, Noel; Barnaeva, Elena; Marugan, Juan J.; Ferrer, Marc] NIH, Chem Genom Ctr, Natl Ctr Advancing Translat Sci, Rockville, MD USA.
   [Agoulnik, Irina U.] Florida Int Univ, Herbert Wertheim Coll Med, Dept Cellular Biol & Pharmacol, 11200 SW 8th St,AHCI 419B, Miami, FL 33199 USA.
RP Agoulnik, AI (reprint author), Florida Int Univ, Herbert Wertheim Coll Med, Dept Human & Mol Genet, 11200 SW 8th St,AHCI 419B, Miami, FL 33199 USA.
EM aagoulni@fiu.edu
OI Southall, Noel/0000-0003-4500-880X; Agoulnik,
   Alexander/0000-0001-6587-6845
FU Florida Department of Health; James and Esther King Biomedical Research
   Program [3KFO1]; National Cancer Institute grant [1U01CA177711];
   National Health and Medical Research Council of Australia [628427,
   1043750]; Victorian Government Operational Infrastructure Support
   Program; NHMRC; MARC U*STAR program fellowship at the Florida
   International University
FX The authors thank Dr. O. David Sherwood, University of Illinois, for
   providing porcine relaxin; Prof. John D. Wade, Florey Institute of
   Neuroscience and Mental Health, Melbourne, VIC, Australia, for providing
   mouse relaxin peptide; Corthera, Inc. (San Mateo, CA, USA) for providing
   recombinant human relaxin and Sharon Layfield and Tania Ferraro for
   technical assistance with studies at the Florey and Shashank Pawitwar
   and Supurna Dhar for their help in cloning rabbit and guinea pig
   receptors. This research was supported by Florida Department of Health,
   James and Esther King Biomedical Research Program grant 3KFO1, and
   National Cancer Institute grant 1U01CA177711 (AA). Research at the
   Florey was supported by National Health and Medical Research Council of
   Australia project grants 628427 and 1043750 and by the Victorian
   Government Operational Infrastructure Support Program. RADB is a
   recipient of an NHMRC Research Fellowship. BH is a recipient of a MARC
   U*STAR program fellowship at the Florida International University.
NR 29
TC 2
Z9 2
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 17
PY 2015
VL 6
AR 128
DI 10.3389/fendo.2015.00128
PG 12
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA DP3MQ
UT WOS:000378398700001
PM 26347712
ER

PT J
AU Ott, C
   Lippincott-Schwartz, J
AF Ott, Carolyn
   Lippincott-Schwartz, Jennifer
TI Cytokinetic Abscission: Timing the Separation
SO CURRENT BIOLOGY
LA English
DT Editorial Material
ID ESCRT-III; PATHWAY; CHECKPOINT; MITD1
AB New work identifies components of the abscission checkpoint that prevent premature severing of the bridge connecting cells at the end of cell division. Kinase activities allow the membrane remodeling machinery to take their mark, but prevent them from leaving the starting block.
C1 [Ott, Carolyn; Lippincott-Schwartz, Jennifer] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
RP Lippincott-Schwartz, J (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA.
EM lippincj@mail.nih.gov
NR 16
TC 0
Z9 0
U1 0
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0960-9822
EI 1879-0445
J9 CURR BIOL
JI Curr. Biol.
PD AUG 17
PY 2015
VL 25
IS 16
BP R722
EP R724
DI 10.1016/j.cub.2015.06.069
PG 3
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP4WB
UT WOS:000359882200014
PM 26294187
ER

PT J
AU Thomas, DG
   Yenepalli, A
   Denais, CM
   Rape, A
   Beach, JR
   Wang, YL
   Schiemann, WP
   Baskaran, H
   Lammerding, J
   Egelhoff, TT
AF Thomas, Dustin G.
   Yenepalli, Aishwarya
   Denais, Celine Marie
   Rape, Andrew
   Beach, Jordan R.
   Wang, Yu-li
   Schiemann, William P.
   Baskaran, Harihara
   Lammerding, Jan
   Egelhoff, Thomas T.
TI Non-muscle myosin IIB is critical for nuclear translocation during 3D
   invasion
SO JOURNAL OF CELL BIOLOGY
LA English
DT Article
ID EPITHELIAL-MESENCHYMAL TRANSITION; MIGRATING CELLS; ADHESION DYNAMICS;
   FOCAL ADHESIONS; SUN PROTEINS; ACTIN FLOW; ENVELOPE; FIBROBLASTS;
   ISOFORMS; NESPRINS
AB Non-muscle myosin II (NMII) is reported to play multiple roles during cell migration and invasion. However, the exact biophysical roles of different NMII isoforms during these processes remain poorly understood. We analyzed the contributions of NMIIA and NMIIB in three-dimensional (3D) migration and in generating the forces required for efficient invasion by mammary gland carcinoma cells. Using traction force microscopy and microfluidic invasion devices, we demonstrated that NMIIA is critical for generating force during active protrusion, and NMIIB plays a major role in applying force on the nucleus to facilitate nuclear translocation through tight spaces. We further demonstrate that the nuclear membrane protein nesprin-2 is a possible linker coupling NMIIB-based force generation to nuclear translocation. Together, these data reveal a central biophysical role for NMIIB in nuclear translocation during 3D invasive migration, a result with relevance not only to cancer metastasis but for 3D migration in other settings such as embryonic cell migration and wound healing.
C1 [Thomas, Dustin G.; Yenepalli, Aishwarya; Egelhoff, Thomas T.] Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA.
   [Thomas, Dustin G.; Egelhoff, Thomas T.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Dept Mol Med, Cleveland, OH 44195 USA.
   [Denais, Celine Marie; Lammerding, Jan] Cornell Univ, Weill Inst Cell & Mol Biol, Dept Biomed Engn, Ithaca, NY 14853 USA.
   [Rape, Andrew] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA.
   [Beach, Jordan R.] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA.
   [Wang, Yu-li] Carnegie Melon Univ, Dept Biomed Engn, Pittsburgh, PA 15219 USA.
   [Schiemann, William P.] Case Western Reserve Univ, Case Comprehens Canc Ctr, Gen Med Sci Oncol, Cleveland, OH 44106 USA.
   [Baskaran, Harihara] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
RP Egelhoff, TT (reprint author), Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA.
EM egelhot@ccf.org
FU National Institute of General Medical Sciences [GM50009]; National
   Institutes of Health Training program in Cancer Pharmacology
   [R25CA1485052-02]; National Science Foundation [ECCS-0335765]; National
   Institutes of Health awards [R01 HL082792]; Department of Defense Breast
   Cancer Idea Award [BC102152]; National Science Foundation CAREER award
   [CBET-1254846]; Cornell Center on the Microenvironment and Metastasis
   from National Cancer Institute [U54CA143876]; National Cancer Institute
   [CA129359]
FX This work was supported by National Institute of General Medical
   Sciences grant GM50009 to T.T. Egelhoff. D.G. Thomas was supported by
   National Institutes of Health Training program in Cancer Pharmacology
   (R25CA1485052-02). This work was performed in part at the Cornell Nano
   Scale Facility, a member of the National Nanotechnology Infrastructure
   Network, which is supported by the National Science Foundation (grant
   ECCS-0335765). This work was supported by National Institutes of Health
   awards (R01 HL082792) to J. Lammerding; the Department of Defense Breast
   Cancer Idea Award (BC102152) to J. Lammerding; a National Science
   Foundation CAREER award (CBET-1254846) to J. Lammerding; and a Pilot
   Project Award by the Cornell Center on the Microenvironment and
   Metastasis through award number U54CA143876 from the National Cancer
   Institute. This work was also supported by National Cancer Institute
   grant CA129359 to W.P. Schiemann.
NR 49
TC 18
Z9 18
U1 3
U2 18
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA
SN 0021-9525
EI 1540-8140
J9 J CELL BIOL
JI J. Cell Biol.
PD AUG 17
PY 2015
VL 210
IS 4
BP 583
EP 594
DI 10.1083/jcb.201502039
PG 12
WC Cell Biology
SC Cell Biology
GA CP3BD
UT WOS:000359750900009
PM 26261182
ER

PT J
AU Hernandez, L
   Noonan, AM
   Sagher, E
   Kohlhammer, H
   Wright, G
   Reed, LT
   Steeg, PS
   Anver, M
   Bowtell, DD
   Annunziata, CM
AF Hernandez, Lidia
   Noonan, Anne M.
   Sagher, Ethan
   Kohlhammer, Holger
   Wright, George
   Reed, L. Tiffany
   Steeg, Patricia S.
   Anver, Miriam
   Bowtell, David D.
   Annunziata, Christina M.
TI Caspase 8 cooperates with IKK beta to protect ovarian cancer cells from
   necroptosis
SO CLINICAL CANCER RESEARCH
LA English
DT Meeting Abstract
CT 10th Biennial Ovarian Cancer Research Symposium
CY SEP 08-09, 2014
CL Seattle, WA
C1 [Hernandez, Lidia; Noonan, Anne M.; Sagher, Ethan; Reed, L. Tiffany; Steeg, Patricia S.; Annunziata, Christina M.] NCI, Womens Malignancies Branch, Bethesda, MD 20892 USA.
   [Kohlhammer, Holger] NCI, Ctr Canc Res, Metab Branch, Bethesda, MD 20892 USA.
   [Wright, George] NCI, Div Canc, Biometr Res Branch, Bethesda, MD 20892 USA.
   [Anver, Miriam] Leidos Biomed Res Inc, LASP, Pathol Histotechnol Lab, Frederick, MD 21702 USA.
   [Bowtell, David D.] Peter MacCallum Canc Ctr, Ctr Canc Genom & Predict Med, East Melbourne, Vic, Australia.
   [Bowtell, David D.] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
EI 1557-3265
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD AUG 15
PY 2015
VL 21
SU 16
MA TECH-1102
DI 10.1158/1557-3265.OVCASYMP14-POSTER-TECH-1102
PG 1
WC Oncology
SC Oncology
GA CR5MD
UT WOS:000361386100032
ER

PT J
AU Noonan, AM
   Hernandez, L
   Herrmann, M
   Chen, JQ
   Annunziata, CM
AF Noonan, Anne M.
   Hernandez, Lidia
   Herrmann, Michelle
   Chen, Jinqui
   Annunziata, Christina M.
TI Development of proteomic biomarkers for the apoptosis pathway in ovarian
   cancer cell lines and determination of the appropriate sequence of the
   SMAC-mimetic birinapant (TL32711) and docetaxel for optimal therapeutic
   effect
SO CLINICAL CANCER RESEARCH
LA English
DT Meeting Abstract
CT 10th Biennial Ovarian Cancer Research Symposium
CY SEP 08-09, 2014
CL Seattle, WA
C1 [Noonan, Anne M.] Ohio State Univ, Columbus, OH 43210 USA.
   [Noonan, Anne M.; Hernandez, Lidia; Herrmann, Michelle; Chen, Jinqui; Annunziata, Christina M.] NCI, NIH, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
EI 1557-3265
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD AUG 15
PY 2015
VL 21
SU 16
MA THER-1422
DI 10.1158/1557-3265.OVCASYMP14-POSTER-THER-1422
PG 1
WC Oncology
SC Oncology
GA CR5MD
UT WOS:000361386100123
ER

PT J
AU Tworoger, SS
   Poole, EM
   Arslan, AA
   Butler, LM
   Kirsh, V
   Lacey, JV
   Lee, IM
   Patel, AV
   Robien, K
   Rohan, T
   Sandler, DP
   Schouten, LJ
   Setiawan, VW
   Visvanathan, K
   Weiderpass, E
   White, E
   Wentzensen, N
AF Tworoger, Shelley S.
   Poole, Elizabeth M.
   Arslan, Alan A.
   Butler, Lesley M.
   Kirsh, Victoria
   Lacey, James V., Jr.
   Lee, I-Min
   Patel, Alpa V.
   Robien, Kim
   Rohan, Thomas
   Sandler, Dale P.
   Schouten, Leo J.
   Setiawan, V. Wendy
   Visvanathan, Kala
   Weiderpass, Elisabete
   White, Emily
   Wentzensen, Nicolas
CA OC3
TI Ovarian cancer risk factor associations by tumor aggressiveness in the
   ovarian cancer cohort consortium (OC3)
SO CLINICAL CANCER RESEARCH
LA English
DT Meeting Abstract
CT 10th Biennial Ovarian Cancer Research Symposium
CY SEP 08-09, 2014
CL Seattle, WA
C1 Brigham & Womens Hosp, Boston, MA 02115 USA.
   Harvard Univ, Cambridge, MA 02138 USA.
   NYU, New York, NY 10003 USA.
   Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   Canc Care Ontario, Toronto, ON, Canada.
   City Hope Natl Med Ctr, London, England.
   Amer Canc Soc, Atlanta, GA 30329 USA.
   George Washington Univ, Washington, DC 20052 USA.
   Albert Einstein Coll Med, Bronx, NY USA.
   NIEHS, Res Triangle Pk, NC USA.
   Maastricht Univ, Maastricht, Netherlands.
   Univ Hawaii, Honolulu, HI 96822 USA.
   Johns Hopkins Bloomberg Sch Publ Hlth & Med, Baltimore, MD USA.
   Karolinska Inst, S-10401 Stockholm, Sweden.
   Fred Hutchinson Canc Res Ctr, Seattle, WA USA.
   NCI, Bethesda, MD 20892 USA.
RI Weiderpass, Elisabete/M-4029-2016
OI Weiderpass, Elisabete/0000-0003-2237-0128
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
EI 1557-3265
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD AUG 15
PY 2015
VL 21
SU 16
MA AS10
DI 10.1158/1557-3265.OVCASYMP14-AS10
PG 2
WC Oncology
SC Oncology
GA CR5MD
UT WOS:000361386100009
ER

PT J
AU Yang, L
   Satpathy, M
   Wang, LY
   Zielinski, R
   Qian, WP
   Lipowska, M
   Capala, J
   Wang, A
   Mao, H
AF Yang, Lily
   Satpathy, Minati
   Wang, Liya
   Zielinski, Rafal
   Qian, Weiping
   Lipowska, Malgorzata
   Capala, Jacek
   Wang, Andrew
   Mao, Hui
TI Image-guided and targeted therapy of advanced ovarian cancer using
   theranostic nanoparticles
SO CLINICAL CANCER RESEARCH
LA English
DT Meeting Abstract
CT 10th Biennial Ovarian Cancer Research Symposium
CY SEP 08-09, 2014
CL Seattle, WA
C1 [Yang, Lily; Satpathy, Minati; Qian, Weiping] Emory Univ, Dept Surg, Atlanta, GA 30322 USA.
   [Wang, Liya; Lipowska, Malgorzata; Mao, Hui] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA.
   [Zielinski, Rafal] Emory Univ, Atlanta, GA 30322 USA.
   [Zielinski, Rafal] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Wang, Andrew] NIH, Radiat Oncol, Bethesda, MD 20892 USA.
   [Wang, Andrew] Ocean Nanotech LLC, San Diego, CA USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
EI 1557-3265
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD AUG 15
PY 2015
VL 21
SU 16
MA THER-1436
DI 10.1158/1557-3265.OVCASYMP14-POSTER-THER-1436
PG 1
WC Oncology
SC Oncology
GA CR5MD
UT WOS:000361386100133
ER

PT J
AU Nettleton, JA
   Follis, JL
   Ngwa, JS
   Smith, CE
   Ahmad, S
   Tanaka, T
   Wojczynski, MK
   Voortman, T
   Lemaitre, RN
   Kristiansson, K
   Nuotio, ML
   Houston, DK
   Perala, MM
   Qi, QB
   Sonestedt, E
   Manichaikul, A
   Kanoni, S
   Ganna, A
   Mikkila, V
   North, KE
   Siscovick, DS
   Harald, K
   Mckeown, NM
   Johansson, I
   Rissanen, H
   Liu, YM
   Lahti, J
   Hu, FB
   Bandinelli, S
   Rukh, G
   Rich, S
   Booij, L
   Dmitriou, M
   Ax, E
   Raitakari, O
   Mukamal, K
   Mannisto, S
   Hallmans, G
   Jula, A
   Ericson, U
   Jacobs, DR
   Van Rooij, FJA
   Deloukas, P
   Sjogren, P
   Kahonen, M
   Djousse, L
   Perola, M
   Barroso, I
   Hofman, A
   Stirrups, K
   Viikari, J
   Uitterlinden, AG
   Kalafati, IP
   Franco, OH
   Mozaffarian, D
   Salomaa, V
   Borecki, IB
   Knekt, P
   Kritchevsky, SB
   Eriksson, JG
   Dedoussis, GV
   Qi, L
   Ferrucci, L
   Orho-Melander, M
   Zillikens, MC
   Ingelsson, E
   Lehtimaki, T
   Renstrom, F
   Cupples, LA
   Loos, RJF
   Franks, PW
AF Nettleton, Jennifer A.
   Follis, Jack L.
   Ngwa, Julius S.
   Smith, Caren E.
   Ahmad, Shafqat
   Tanaka, Toshiko
   Wojczynski, Mary K.
   Voortman, Trudy
   Lemaitre, Rozenn N.
   Kristiansson, Kati
   Nuotio, Marja-Liisa
   Houston, Denise K.
   Perala, Mia-Maria
   Qi, Qibin
   Sonestedt, Emily
   Manichaikul, Ani
   Kanoni, Stavroula
   Ganna, Andrea
   Mikkila, Vera
   North, Kari E.
   Siscovick, David S.
   Harald, Kennet
   Mckeown, Nicola M.
   Johansson, Ingegerd
   Rissanen, Harri
   Liu, Yongmei
   Lahti, Jari
   Hu, Frank B.
   Bandinelli, Stefania
   Rukh, Gull
   Rich, Stephen
   Booij, Lisanne
   Dmitriou, Maria
   Ax, Erika
   Raitakari, Olli
   Mukamal, Kenneth
   Mannisto, Satu
   Hallmans, Goran
   Jula, Antti
   Ericson, Ulrika
   Jacobs, David R., Jr.
   Van Rooij, Frank J. A.
   Deloukas, Panos
   Sjogren, Per
   Kahonen, Mika
   Djousse, Luc
   Perola, Markus
   Barroso, Ines
   Hofman, Albert
   Stirrups, Kathleen
   Viikari, Jorma
   Uitterlinden, Andre G.
   Kalafati, Ioanna P.
   Franco, Oscar H.
   Mozaffarian, Dariush
   Salomaa, Veikko
   Borecki, Ingrid B.
   Knekt, Paul
   Kritchevsky, Stephen B.
   Eriksson, Johan G.
   Dedoussis, George V.
   Qi, Lu
   Ferrucci, Luigi
   Orho-Melander, Marju
   Zillikens, M. Carola
   Ingelsson, Erik
   Lehtimaki, Terho
   Renstrom, Frida
   Cupples, L. Adrienne
   Loos, Ruth J. F.
   Franks, Paul W.
TI Gene x dietary pattern interactions in obesity: analysis of up to 68 317
   adults of European ancestry
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID BODY-MASS INDEX; DIABETES PREVENTION PROGRAM; PHYSICAL-ACTIVITY;
   ENVIRONMENT INTERACTIONS; GLUCOSE-HOMEOSTASIS; FASTING GLUCOSE;
   WEIGHT-LOSS; LOCI; METAANALYSIS; INDIVIDUALS
AB Obesity is highly heritable. Genetic variants showing robust associationswith obesity traits have been identified through genome wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphismswere genotyped, and genetic risk scores (GRS) were calculated in 18 cohorts of European ancestry (n = 68 317). Diet score was calculated based on self-reported intakes of whole grains, fish, fruits, vegetables, nuts/seeds (favorable) and red/processed meats, sweets, sugar-sweetened beverages and fried potatoes (unfavorable). Multivariable adjusted, linear regression within each cohort followed by inverse variance-weighted, fixed-effects meta-analysis was used to characterize: (a) associations of each GRS with BMI and BMI-adjustedWHR and (b) diet score modification of genetic associations with BMI and BMI-adjusted WHR. Nominally significant interactions (P = 0.006-0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjustedWHR or BMI outcomes. Although the magnitudes of these select interactions were small, our data indicated that associations between genetic predisposition and obesity traits were stronger with a healthier diet. Our findings generate interesting hypotheses; however, experimental and functional studies are needed to determine their clinical relevance.
C1 [Nettleton, Jennifer A.] Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA.
   [Follis, Jack L.] Univ St Thomas, Dept Math, Houston, TX 77006 USA.
   [Ngwa, Julius S.; Cupples, L. Adrienne] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.
   [Smith, Caren E.; Mckeown, Nicola M.] Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA USA.
   [Smith, Caren E.; Mckeown, Nicola M.; Mozaffarian, Dariush] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
   [Ahmad, Shafqat; Renstrom, Frida; Franks, Paul W.] Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.
   [Sonestedt, Emily; Rukh, Gull; Ericson, Ulrika; Orho-Melander, Marju] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
   [Tanaka, Toshiko; Ferrucci, Luigi] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   [Wojczynski, Mary K.; Borecki, Ingrid B.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
   [Voortman, Trudy; Van Rooij, Frank J. A.; Hofman, Albert; Franco, Oscar H.] Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
   [Voortman, Trudy; Booij, Lisanne; Van Rooij, Frank J. A.; Hofman, Albert; Uitterlinden, Andre G.; Franco, Oscar H.; Zillikens, M. Carola] NCHA, Netherlands Genom Initiat NGI Sponsored Netherlan, Leiden, Netherlands.
   [Lemaitre, Rozenn N.] Univ Washington, Dept Med, Seattle, WA 98195 USA.
   [Kristiansson, Kati; Nuotio, Marja-Liisa; Perola, Markus] Natl Inst Hlth & Welf, Unit Publ Hlth Genom, Helsinki 00290, Finland.
   [Perala, Mia-Maria; Mannisto, Satu; Eriksson, Johan G.] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00290, Finland.
   [Nuotio, Marja-Liisa; Perola, Markus] Univ Helsinki, Inst Mol Med Finland FIMM, FIN-00290 Helsinki, Finland.
   [Houston, Denise K.; Kritchevsky, Stephen B.] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC USA.
   [Liu, Yongmei] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
   [Qi, Qibin; Hu, Frank B.; Qi, Lu; Franks, Paul W.] Harvard Univ, Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Qi, Qibin] Albert Einstein Coll Med, Dept Epidemiol & Publ Hlth, Bronx, NY 10467 USA.
   [Manichaikul, Ani; Rich, Stephen] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
   [Manichaikul, Ani] Univ Virginia, Dept Publ Hlth Sci, Div Biostat & Epidemiol, Charlottesville, VA USA.
   [Kanoni, Stavroula; Stirrups, Kathleen] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
   [Ganna, Andrea] Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.
   [Mikkila, Vera] Univ Helsinki, Dept Food & Environm Sci, Helsinki, Finland.
   [Lahti, Jari] Univ Helsinki, Inst Behav Sci, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Inst Clin Med, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Mikkila, Vera; Raitakari, Olli] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [North, Kari E.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
   [North, Kari E.] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.
   [Siscovick, David S.] New York Acad Med, New York, NY USA.
   [Harald, Kennet; Rissanen, Harri; Jula, Antti; Salomaa, Veikko; Knekt, Paul] THL Natl Inst Hlth & Welf, Helsinki 00300, Finland.
   [Johansson, Ingegerd] Umea Univ, Dept Odontol, Umea, Sweden.
   [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden.
   [Renstrom, Frida] Umea Univ, Dept Biobank Res, Umea, Sweden.
   [Franks, Paul W.] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Lahti, Jari; Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Bandinelli, Stefania] ASF, Geriatr Unit, Florence, Italy.
   [Booij, Lisanne; Uitterlinden, Andre G.; Zillikens, M. Carola] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Dmitriou, Maria; Kalafati, Ioanna P.; Dedoussis, George V.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Ax, Erika; Sjogren, Per] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, Uppsala, Sweden.
   [Ingelsson, Erik] Uppsala Univ, Dept Med Sci Mol Epidemiol, Uppsala, Sweden.
   [Ingelsson, Erik] Uppsala Univ, Sci Life Lab, Uppsala, Sweden.
   [Raitakari, Olli] Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland.
   [Viikari, Jorma] Univ Turku, Dept Med, Turku, Finland.
   [Viikari, Jorma] Turku Univ Hosp, Div Med, FIN-20520 Turku, Finland.
   [Mukamal, Kenneth] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
   [Jacobs, David R., Jr.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Deloukas, Panos] Wellcome Trust Sanger Inst, Hinxton, Cambs, England.
   [Kahonen, Mika] Univ Tampere, Dept Clin Physiol, FIN-33101 Tampere, Finland.
   [Kahonen, Mika] Tampere Univ Hosp, Tampere, Finland.
   [Djousse, Luc] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA.
   [Djousse, Luc] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Djousse, Luc] Boston VA Healthcare Syst, Boston, MA USA.
   [Perola, Markus] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
   [Barroso, Ines] Wellcome Trust Sanger Inst, Metab Dis Grp, Hinxton, Cambs, England.
   [Barroso, Ines] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 2QQ, England.
   [Eriksson, Johan G.] Helsinki Univ Cent Hosp, Unit Gen Practice, Helsinki, Finland.
   [Lehtimaki, Terho] Univ Tampere, Dept Clin Chem, Fimlab Labs, FIN-33101 Tampere, Finland.
   [Lehtimaki, Terho] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.
   [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.
   [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP Franks, PW (reprint author), Skane Univ Hosp Malmo, CRC, Dept Clin Sci Genet & Mol Epidemiol, Bldg 91,Level 10,Jan Waldenstroms Gata 35, SE-20502 Malmo, Sweden.
EM paul.franks@med.lu.se
RI Sonestedt, Emily/I-3814-2016; Voortman, Trudy/C-2963-2015; Deloukas,
   Panos/B-2922-2013; Djousse, Luc/F-5033-2017
OI Sonestedt, Emily/0000-0002-0747-4562; Voortman,
   Trudy/0000-0003-2830-6813; Deloukas, Panos/0000-0001-9251-070X; Djousse,
   Luc/0000-0002-9902-3047
FU National Heart, Lung, and Blood Institute [R01HL105756]; Nutrition
   Working Group within CHARGE; career development award from the National
   Institutes of Health, National Institute of Diabetes and Digestive and
   Kidney Diseases [5K01DK082729-04]; Distinguished Young Research Award in
   Medicine from the Swedish Research Council; EXODIAB; Swedish Research
   Council
FX Infrastructure for the Cohorts for Heart and Aging Research in Genomic
   Epidemiology (CHARGE) consortium was supported in part by the National
   Heart, Lung, and Blood Institute Grant No. R01HL105756. Each cohort
   participating in the present investigation, conducted by the Nutrition
   Working Group within CHARGE, was independently funded. J.A.N. was funded
   by a career development award from the National Institutes of Health,
   National Institute of Diabetes and Digestive and Kidney Diseases
   (5K01DK082729-04). P.W.F. was funded by a Distinguished Young Research
   Award in Medicine from the Swedish Research Council and EXODIAB. Funding
   to pay the Open Access publication charges for this article was provided
   by the Swedish Research Council. Cohort-specific funding and
   acknowledgments follow in the sections below.
NR 33
TC 10
Z9 11
U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD AUG 15
PY 2015
VL 24
IS 16
BP 4728
EP 4738
DI 10.1093/hmg/ddv186
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CR4OU
UT WOS:000361315400020
PM 25994509
ER

PT J
AU Gerasimova, T
   Guo, CY
   Ghosh, A
   Qiu, X
   Montefiori, L
   Verma-Gaur, J
   Choi, NM
   Feeney, AJ
   Sen, R
AF Gerasimova, Tatiana
   Guo, Changying
   Ghosh, Amalendu
   Qiu, Xiang
   Montefiori, Lindsey
   Verma-Gaur, Jiyoti
   Choi, Nancy M.
   Feeney, Ann J.
   Sen, Ranjan
TI A structural hierarchy mediated by multiple nuclear factors establishes
   IgH locus conformation
SO GENES & DEVELOPMENT
LA English
DT Article
DE chromosome conformation; looping; architectural proteins
ID HEAVY-CHAIN LOCUS; PRO-B CELLS; CCCTC-BINDING FACTOR; V(D)J
   RECOMBINATION; INTRONIC ENHANCER; CHROMOSOMAL TRANSLOCATIONS; LYMPHOCYTE
   DEVELOPMENT; GENOMIC INTERACTIONS; IMMUNOGLOBULIN LOCI; GENE
   AMPLIFICATION
AB Conformation of antigen receptor gene loci spatially juxtaposes rearranging gene segments in the appropriate cell lineage and developmental stage. We describe a three-step pathway that establishes the structure of the 2.8-Mb immunoglobulin heavy chain gene (IgH) locus in pro-B cells. Each step uses a different transcription factor and leads to increasing levels of structural organization. CTCF mediates one level of compaction that folds the locus into several 250- to 400-kb subdomains, and Pax5 further compacts the 2-Mb region that encodes variable (V-H) gene segments. The 5' and 3' domains are brought together by the transcription factor YY1 to establish the configuration within which gene recombination initiates. Such stepwise mechanisms may apply more generally to establish regulatory fine structure within megabase-sized topologically associated domains.
C1 [Gerasimova, Tatiana; Guo, Changying; Ghosh, Amalendu; Qiu, Xiang; Montefiori, Lindsey; Sen, Ranjan] NIA, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA.
   [Verma-Gaur, Jiyoti; Choi, Nancy M.; Feeney, Ann J.] Scripps Res Inst, La Jolla, CA 92037 USA.
RP Sen, R (reprint author), NIA, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA.
EM senra@mail.nih.gov
FU Intramural Research Program of the National Institutes of Health;
   National Institute on Aging; National Institutes of Health [R01 AI
   082918]
FX E<SUP>-</SUP>P<SUP>-</SUP> mice and Abelson virus transformed cell lines
   lacking E mu were generously provided by Eugene Oltz (Washington
   University School of Medicine, St. Louis, MO) and Fred Alt (Boston
   Children's Hospital, Boston, MA), respectively. Pax-5-deficient pro-B
   cells and S17 stromal cells were provided by Jagan Pongubala (University
   of Hyderabad, India), and Pax5<SUP>-</SUP>RAG2<SUP>-</SUP> pro-B cells
   were the gift of Meinrad Busslinger (Institute of Molecular Pathology,
   Vienna). We thank Dinah Singer (National Cancer Institute) for critical
   reading of the manuscript. This work was supported in part by the
   Intramural Research Program of the National Institutes of Health, by the
   National Institute on Aging, and in part by National Institutes of
   Health grant R01 AI 082918 to A.J.F. T.G., C.G., and R.S. designed the
   study. T.G. carried out all of the FISH experiments and C.G. and X.Q.
   carried out all ChIP and 3C experiments. L.M. assisted in FISH studies,
   and A.G. provided pro-B cells after expansion in culture on OP9 or S17
   stromal cells. J.V.-G., N.M.C., and A.J.F. generated the CTCF-deficient
   and YY1-deficient primary pro-B cells used in these studies. R.S. wrote
   the manuscript, and all of the authors, especially A.J.F., provided
   essential comments.
NR 45
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Z9 8
U1 3
U2 5
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 0890-9369
EI 1549-5477
J9 GENE DEV
JI Genes Dev.
PD AUG 15
PY 2015
VL 29
IS 16
BP 1683
EP 1695
DI 10.1101/gad.263871.115
PG 13
WC Cell Biology; Developmental Biology; Genetics & Heredity
SC Cell Biology; Developmental Biology; Genetics & Heredity
GA CQ1RP
UT WOS:000360376600002
PM 26302788
ER

PT J
AU Mateus, R
   Lourenco, R
   Fang, Y
   Brito, G
   Farinho, A
   Valerio, F
   Jacinto, A
AF Mateus, Rita
   Lourenco, Raquel
   Fang, Yi
   Brito, Goncalo
   Farinho, Ana
   Valerio, Fabio
   Jacinto, Antonio
TI Control of tissue growth by Yap relies on cell density and F-actin in
   zebrafish fin regeneration
SO DEVELOPMENT
LA English
DT Article
DE Zebrafish; Fin regeneration; Hippo/Yap; F-actin; Cell density
ID HIPPO SIGNALING PATHWAY; TRANSCRIPTIONAL COACTIVATOR; CONTACT
   INHIBITION; PROTEIN YAP; PROLIFERATION; EXPRESSION; DROSOPHILA;
   INDUCTION; APOPTOSIS; CATENIN
AB Caudal fin regeneration is characterized by a proliferation boost in the mesenchymal blastema that is controlled precisely in time and space. This allows a gradual and robust restoration of original fin size. However, how this is established and regulated is not well understood. Here, we report that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating Yap during regeneration dramatically affects cell proliferation and expression of key signaling pathways, impacting regenerative growth. The intracellular location of Yap is tightly associated with different cell densities along the blastema proximal-distal axis, which correlate with alterations in cell morphology, cytoskeleton and cell-cell contacts in a gradient-like manner. Importantly, Yap inactivation occurs in high cell density areas, conditional to F-actin distribution and polymerization. We propose that Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
C1 [Mateus, Rita; Lourenco, Raquel; Farinho, Ana; Valerio, Fabio; Jacinto, Antonio] NOVA Univ Lisbon, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal.
   [Fang, Yi] NIEHS, Durham, NC 27709 USA.
   [Brito, Goncalo; Farinho, Ana] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal.
   [Jacinto, Antonio] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal.
RP Jacinto, A (reprint author), NOVA Univ Lisbon, NOVA Med Sch, CEDOC, Campo Martires Patria 130, P-1169056 Lisbon, Portugal.
EM antonio.jacinto@fcm.unl.pt
RI Jacinto, Antonio/F-5729-2013; Faculdade de Ciencias Medicas, Nova
   Medical School/K-6209-2013
OI Jacinto, Antonio/0000-0002-4193-6089; 
FU Fundacao para a Ciencia e Tecnologia [SFRH/BD/62126/2009,
   PTDC/BEX-BID/1176/2012]; Agence Nationale de la Recherche
   [ANR-11-BSV5-0021]
FX This work was supported by funding from Fundacao para a Ciencia e
   Tecnologia [SFRH/BD/62126/2009, PTDC/BEX-BID/1176/2012]; and Agence
   Nationale de la Recherche [ANR-11-BSV5-0021].
NR 61
TC 6
Z9 6
U1 1
U2 15
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 0950-1991
EI 1477-9129
J9 DEVELOPMENT
JI Development
PD AUG 15
PY 2015
VL 142
IS 16
BP 2752
EP +
DI 10.1242/dev.119701
PG 32
WC Developmental Biology
SC Developmental Biology
GA CP5VT
UT WOS:000359953800005
PM 26209644
ER

PT J
AU Kim, SH
   Burton, J
   Yu, CR
   Sun, L
   He, C
   Wang, HS
   Morse, HC
   Egwuagu, CE
AF Kim, Sung-Hye
   Burton, Jenna
   Yu, Cheng-Rong
   Sun, Lin
   He, Chang
   Wang, Hongsheng
   Morse, Herbert C., III
   Egwuagu, Charles E.
TI Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis:
   Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in
   the Retina Confers Protection
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID INTERFERON REGULATORY FACTOR-8; SEQUENCE BINDING-PROTEIN;
   GENE-EXPRESSION; B-CELLS; DIFFERENTIATION; INFLAMMATION; MECHANISMS;
   ENCEPHALOMYELITIS; INTERLEUKIN-27; SPECIFICATION
AB IFN regulatory factor 8 (IRF8) is constitutively expressed in monocytes and B cells and plays a critical role in the functional maturation of microglia cells. It is induced in T cells following Ag stimulation, but its functions are less well understood. However, recent studies in mice with T cell-specific Irf8 disruption under direction of the Lck promoter (LCK-IRF8KO) suggest that IRF8 directs a silencing program for Th17 differentiation, and IL-17 production is markedly increased in IRF8-deficient T cells. Paradoxically, loss of IRF8 in T cells has no effect on the development or severity of experimental autoimmune encephalomyelitis (EAE), although exacerbating colitis in a mouse colitis model. In contrast, mice with a macrophage/microglia-specific Irf8 disruption are resistant to EAE, further confounding our understanding of the roles of IRF8 in host immunity and autoimmunity. To clarify the role of IRF8 in autoimmune diseases, we have generated two mouse strains with targeted deletion of Irf8 in retinal cells, including microglial cells and a third mouse strain with targeted Irf8 deletion in T cells under direction of the nonpromiscuous, CD4 promoter (CD4-IRF8KO). In contrast to the report that IRF8 deletion in T cells has no effect on EAE, experimental autoimmune uveitis is exacerbated in CD4-IRF8KO mice and disease enhancement correlates with significant expansion of Th17 cells and a reduction in T regulatory cells. In contrast to CD4-IRF8KO mice, Irf8 deletion in retinal cells confers protection from uveitis, underscoring divergent and tissue-specific roles of IRF8 in host immunity. These results raise a cautionary note in the context of therapeutic targeting of IRF8.
C1 [Kim, Sung-Hye; Burton, Jenna; Yu, Cheng-Rong; Sun, Lin; He, Chang; Egwuagu, Charles E.] NEI, Mol Immunol Sect, NIH, Bethesda, MD 20892 USA.
   [Wang, Hongsheng; Morse, Herbert C., III] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
RP Egwuagu, CE (reprint author), NEI, Mol Immunol Sect, NIH, Bldg 10,Room 10N109A,10 Ctr Dr, Bethesda, MD 20892 USA.
EM egwuaguc@nei.nih.gov
RI Sun, Lin/I-3146-2016
FU Intramural NIH HHS [ZIA EY000350-15, ZIA EY000280-23, ZIA EY000315-23]
NR 46
TC 4
Z9 4
U1 0
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD AUG 15
PY 2015
VL 195
IS 4
BP 1480
EP 1488
DI 10.4049/jimmunol.1500653
PG 9
WC Immunology
SC Immunology
GA CP6QO
UT WOS:000360013200018
PM 26163590
ER

PT J
AU Alhajjat, AM
   Strong, BS
   Lee, AE
   Turner, LE
   Wadhwani, RK
   Ortaldo, JR
   Heusel, JW
   Shaaban, AF
AF Alhajjat, Amir M.
   Strong, Beverly S.
   Lee, Amanda E.
   Turner, Lucas E.
   Wadhwani, Ram K.
   Ortaldo, John R.
   Heusel, Jonathan W.
   Shaaban, Aimen F.
TI Prenatal Allospecific NK Cell Tolerance Hinges on Instructive
   Allorecognition through the Activating Receptor during Development
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID NATURAL-KILLER-CELLS; MHC CLASS-I; ALLOGENEIC BONE-MARROW; INHIBITORY
   RECEPTORS; SELF-TOLERANCE; EXPRESSION; EDUCATION; REPERTOIRE; MOLECULES;
   LIGAND
AB Little is known about how the prenatal interaction between NK cells and alloantigens shapes the developing NK cell repertoire toward tolerance or immunity. Specifically, the effect on NK cell education arising from developmental corecognition of alloantigens by activating and inhibitory receptors with shared specificity is uncharacterized. Using a murine prenatal transplantation model, we examined the manner in which this seemingly conflicting input affects NK cell licensing and repertoire formation in mixed hematopoietic chimeras. We found that prenatal NK cell tolerance arose from the elimination of phenotypically hostile NK cells that express an allospecific activating receptor without coexpressing any allospecific inhibitory receptors. Importantly, the checkpoint for the system appeared to occur centrally within the bone marrow during the final stage of NK cell maturation and hinged on the instructive recognition of allogeneic ligand by the activating receptor rather than through the inhibitory receptor as classically proposed. Residual nondeleted hostile NK cells expressing only the activating receptor exhibited an immature, anergic phenotype, but retained the capacity to upregulate inhibitory receptor expression in peripheral sites. However, the potential for this adaptive change to occur was lost in developmentally mature chimeras. Collectively, these findings illuminate the intrinsic process in which developmental allorecognition through the activating receptor regulates the emergence of durable NK cell tolerance and establishes a new paradigm to fundamentally guide future investigations of prenatal NK cell-allospecific education.
C1 [Alhajjat, Amir M.] Univ Iowa, Carver Coll Med, Dept Surg, Iowa City, IA 52242 USA.
   [Strong, Beverly S.; Lee, Amanda E.; Turner, Lucas E.; Wadhwani, Ram K.; Shaaban, Aimen F.] Cincinnati Childrens Hosp Med Ctr, Dept Surg, Cincinnati, OH 45229 USA.
   [Strong, Beverly S.; Lee, Amanda E.; Turner, Lucas E.; Wadhwani, Ram K.; Shaaban, Aimen F.] Univ Cincinnati, Coll Med, Cincinnati, OH 45229 USA.
   [Ortaldo, John R.] NCI, Expt Therapeut Sect, Frederick, MD 21702 USA.
   [Heusel, Jonathan W.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
   [Heusel, Jonathan W.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
RP Shaaban, AF (reprint author), Cincinnati Childrens Hosp Med Ctr, Dept Surg, Ctr Fetal Cellular & Mol Therapy, 3333 Burnet Ave,MLC 11025, Cincinnati, OH 45229 USA.
EM aimen.shaaban@cchmc.org
OI Shaaban, Aimen/0000-0002-9459-107X
FU National Institutes of Health [AR47363, DK78392, DK90971]; Carver
   College of Medicine; Holden Comprehensive Cancer Center; Iowa City
   Veteran's Administration Medical Center
FX We appreciate the skillful technical assistance of Tess Newkold, Bhavana
   Makkapati, and George Tzanetakos. We thank Drs. Zuhair Ballas and Kasper
   Hoebe for helpful discussions and reading of the manuscript. We would
   like to acknowledge the assistance of the Research Flow Cytometry Core
   in the Division of Rheumatology at Cincinnati Children's Hospital
   Medical Center (supported in part by National Institutes of Health
   Grants AR47363, DK78392 and DK90971) and the Flow Cytometry Facility of
   the University of Iowa Carver College of Medicine (funded through user
   fees and the generous financial support of the Carver College of
   Medicine, the Holden Comprehensive Cancer Center, and the Iowa City
   Veteran's Administration Medical Center).
NR 46
TC 2
Z9 2
U1 0
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD AUG 15
PY 2015
VL 195
IS 4
BP 1506
EP 1516
DI 10.4049/jimmunol.1500463
PG 11
WC Immunology
SC Immunology
GA CP6QO
UT WOS:000360013200021
PM 26136432
ER

PT J
AU Hunsberger, JG
   Efthymiou, AG
   Malik, N
   Behl, M
   Mead, IL
   Zeng, XM
   Simeonov, A
   Rao, M
AF Hunsberger, Joshua G.
   Efthymiou, Anastasia G.
   Malik, Nasir
   Behl, Mamta
   Mead, Ivy L.
   Zeng, Xianmin
   Simeonov, Anton
   Rao, Mahendra
TI Induced Pluripotent Stem Cell Models to Enable In Vitro Models for
   Screening in the Central Nervous System
SO STEM CELLS AND DEVELOPMENT
LA English
DT Review
ID HUMAN BRAIN-DEVELOPMENT; DRUG DISCOVERY; PARKINSONS-DISEASE;
   ALZHEIMERS-DISEASE; MOTOR-NEURONS; PC12 CELLS; TOXICITY; NEUROTOXICITY;
   GENERATION; CULTURE
AB There is great need to develop more predictive drug discovery tools to identify new therapies to treat diseases of the central nervous system (CNS). Current nonpluripotent stem cell-based models often utilize non-CNS immortalized cell lines and do not enable the development of personalized models of disease. In this review, we discuss why in vitro models are necessary for translational research and outline the unique advantages of induced pluripotent stem cell (iPSC)-based models over those of current systems. We suggest that iPSC-based models can be patient specific and isogenic lines can be differentiated into many neural cell types for detailed comparisons. iPSC-derived cells can be combined to form small organoids, or large panels of lines can be developed that enable new forms of analysis. iPSC and embryonic stem cell-derived cells can be readily engineered to develop reporters for lineage studies or mechanism of action experiments further extending the utility of iPSC-based systems. We conclude by describing novel technologies that include strategies for the development of diversity panels, novel genomic engineering tools, new three-dimensional organoid systems, and modified high-content screens that may bring toxicology into the 21st century. The strategic integration of these technologies with the advantages of iPSC-derived cell technology, we believe, will be a paradigm shift for toxicology and drug discovery efforts.
C1 [Hunsberger, Joshua G.; Mead, Ivy L.] Wake Forest Inst Regenerat Med, Winston Salem, NC 27101 USA.
   [Efthymiou, Anastasia G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Malik, Nasir] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Behl, Mamta] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
   [Zeng, Xianmin] Buck Inst Age Res, Novato, CA USA.
   [Simeonov, Anton] NIH, NCATS, Rockville, MD USA.
   [Rao, Mahendra] New York Stem Cell Fdn, New York, NY USA.
RP Hunsberger, JG (reprint author), Wake Forest Inst Regenerat Med, Richard H Dean Biomed Bldg,391 Technol Way, Winston Salem, NC 27101 USA.
EM jhunsber@wakehealth.edu
OI Efthymiou, Anastasia/0000-0002-1769-5078
NR 102
TC 2
Z9 2
U1 5
U2 29
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1547-3287
EI 1557-8534
J9 STEM CELLS DEV
JI Stem Cells Dev.
PD AUG 15
PY 2015
VL 24
IS 16
BP 1852
EP 1864
DI 10.1089/scd.2014.0531
PG 13
WC Cell & Tissue Engineering; Hematology; Medicine, Research &
   Experimental; Transplantation
SC Cell Biology; Hematology; Research & Experimental Medicine;
   Transplantation
GA CP4JM
UT WOS:000359847800002
PM 25794298
ER

PT J
AU Kondo, S
   Fujiki, K
   Ko, SBH
   Yamamoto, A
   Nakakuki, M
   Ito, Y
   Shcheynikov, N
   Kitagawa, M
   Naruse, S
   Ishiguro, H
AF Kondo, Shiho
   Fujiki, Kotoyo
   Ko, Shigeru B. H.
   Yamamoto, Akiko
   Nakakuki, Miyuki
   Ito, Yasutomo
   Shcheynikov, Nikolay
   Kitagawa, Motoji
   Naruse, Satoru
   Ishiguro, Hiroshi
TI Functional characteristics of L1156F-CFTR associated with alcoholic
   chronic pancreatitis in Japanese
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE CFTR gene; L1156F; alcoholic chronic pancreatitis; Japanese
ID FIBROSIS TRANSMEMBRANE CONDUCTANCE; IDIOPATHIC CHRONIC-PANCREATITIS;
   REGULATOR CFTR GENE; CYSTIC-FIBROSIS; MOLECULAR-MECHANISM; DUCT CELLS;
   MUTATION; SWEAT; DISEASES; POLYMORPHISM
AB Although cystic fibrosis is rare in Japanese, measurement of sweat Cl- has suggested mild dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR) in some patients with chronic pancreatitis. In the present study, we have investigated the association of CFTR variants and chronic pancreatitis in Japanese and the functional characteristics of a Japanese- and pancreatitis-specific CFTR variant, L1156F. Seventy patients with alcoholic chronic pancreatitis, 18 patients with idiopathic chronic pancreatitis, and 180 normal subjects participated. All exons and their boundaries and promoter region of the CFTR gene were sequenced. Human embryonic kidney-293 cells were transfected with three CFTR variants (M470V, L1156F, and M470V + L1156F), and the protein expression was examined. Xenopus laevis oocytes were injected with the CFTR variants, and bicarbonate (HCO3-) transport activity was examined. CFPAC-1 cells were transfected with the CFTR variants and Cl-/HCO3- exchange activity was examined. Six variants (E217G, I556V, M470V, L1156F, Q1352H, and R1453W) were identified in the coding region of the CFTR gene. Cystic fibrosis-causing mutations were not found. The allele frequencies of L1156F and Q1352H in alcoholic chronic pancreatitis (5.0 and 7.9%) were significantly (P < 0.01) higher than those in normal subjects (0.6 and 1.9%). L1156F was linked with a worldwide CFTR variant, M470V. Combination of M470V and L1156F significantly reduced CFTR expression to similar to 60%, impaired CFTR-mediated HCO3-/Cl- transport activity to 50-60%, and impaired CFTR-coupled Cl-/HCO3- exchange activity to 20-30%. The data suggest that the Japanese-specific CFTR variant L1156F causes mild dysfunction of CFTR and increases the risk of alcoholic chronic pancreatitis in Japanese.
C1 [Kondo, Shiho; Yamamoto, Akiko; Nakakuki, Miyuki; Ishiguro, Hiroshi] Nagoya Univ, Grad Sch Med, Dept Human Nutr, Nagoya, Aichi 4648601, Japan.
   [Fujiki, Kotoyo; Kitagawa, Motoji] Nagoya Univ Arts & Sci, Dept Nutr, Nisshin, Japan.
   [Ko, Shigeru B. H.] Keio Univ, Sch Med, Dept Syst Med, Tokyo, Japan.
   [Ito, Yasutomo] Nagoya Univ, Grad Sch Med, Div Med Res Engn, Nagoya, Aichi 4648601, Japan.
   [Shcheynikov, Nikolay] Natl Inst Dent & Craniofacial Res, Epithelial Signaling & Transport Sect, Bethesda, MD USA.
   [Naruse, Satoru] Miyoshi Municipal Hosp, Miyoshi, Japan.
RP Ishiguro, H (reprint author), Nagoya Univ, Human Nutr, Grad Sch Med, Res Ctr Hlth Phys Fitness & Sports,Chikusa Ku, Furo Cho E5-2 130, Nagoya, Aichi 4648601, Japan.
EM ishiguro@htc.nagoya-u.ac.jp
RI YAMAMOTO, Akiko/M-8932-2014; ISHIGURO, Hiroshi/M-8851-2014
FU Pancreas Research Foundation of Japan; Japan Society for the Promotion
   of Science; Research Committee of Intractable Pancreatic Diseases
FX This work was supported by Pancreas Research Foundation of Japan and
   grants from the Japan Society for the Promotion of Science and the
   Research Committee of Intractable Pancreatic Diseases (principal
   investigators: Tooru Shimosegawa, Yoshifumi Takeyama) provided by the
   Ministry of Health, Labour, and Welfare of Japan.
NR 48
TC 1
Z9 1
U1 1
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD AUG 15
PY 2015
VL 309
IS 4
BP G260
EP G269
DI 10.1152/ajpgi.00015.2014
PG 10
WC Gastroenterology & Hepatology; Physiology
SC Gastroenterology & Hepatology; Physiology
GA CP2WC
UT WOS:000359737300006
PM 26089335
ER

PT J
AU Vuong, H
   Che, A
   Ravichandran, S
   Luke, BT
   Collins, JR
   Mudunuri, US
AF Vuong, Hue
   Che, Anney
   Ravichandran, Sarangan
   Luke, Brian T.
   Collins, Jack R.
   Mudunuri, Uma S.
TI AVIA v2.0: annotation, visualization and impact analysis of genomic
   variants and genes
SO BIOINFORMATICS
LA English
DT Article
ID INTEGRATION
AB As sequencing becomes cheaper and more widely available, there is a greater need to quickly and effectively analyze large-scale genomic data. While the functionality of AVIA v1.0, whose implementation was based on ANNOVAR, was comparable with other annotation web servers, AVIA v2.0 represents an enhanced web-based server that extends genomic annotations to cell-specific transcripts and protein-level functional annotations. With AVIA's improved interface, users can better visualize their data, perform comprehensive searches and categorize both coding and non-coding variants.
C1 [Vuong, Hue; Che, Anney; Ravichandran, Sarangan; Luke, Brian T.; Collins, Jack R.; Mudunuri, Uma S.] Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Frederick, MD 21702 USA.
RP Vuong, H (reprint author), Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Frederick, MD 21702 USA.
EM Hue.Vuong@fnlcr.nih.gov
FU National Cancer Institute, National Institutes of Health
   [HHSN261200800001E]
FX This work was supported with federal funds from the National Cancer
   Institute, National Institutes of Health [contract HHSN261200800001E].
   The content of this publication does not necessarily reflect the views
   of policies of the Department of Health and Human Services, nor does
   mention of trade names, commercial products or organizations imply
   endorsement by the U.S. government.
NR 9
TC 4
Z9 4
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1367-4803
EI 1460-2059
J9 BIOINFORMATICS
JI Bioinformatics
PD AUG 15
PY 2015
VL 31
IS 16
BP 2748
EP 2750
DI 10.1093/bioinformatics/btv200
PG 3
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
   Computer Science, Interdisciplinary Applications; Mathematical &
   Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Computer Science; Mathematical & Computational Biology; Mathematics
GA CP1WC
UT WOS:000359666600022
PM 25861966
ER

PT J
AU Grapov, D
   Wanichthanarak, K
   Fiehn, O
AF Grapov, Dmitry
   Wanichthanarak, Kwanjeera
   Fiehn, Oliver
TI MetaMapR: pathway independent metabolomic network analysis incorporating
   unknowns
SO BIOINFORMATICS
LA English
DT Article
ID INFORMATION; SIMILARITY; CYTOSCAPE; METSCAPE
AB Metabolic network mapping is a widely used approach for integration of metabolomic experimental results with biological domain knowledge. However, current approaches can be limited by biochemical domain or pathway knowledge which results in sparse disconnected graphs for real world metabolomic experiments. MetaMapR integrates enzymatic transformations with metabolite structural similarity, mass spectral similarity and empirical associations to generate richly connected metabolic networks. This open source, web-based or desktop software, written in the R programming language, leverages KEGG and PubChem databases to derive associations between metabolites even in cases where biochemical domain or molecular annotations are unknown. Network calculation is enhanced through an interface to the Chemical Translation System, which allows metabolite identifier translation between >200 common biochemical databases. Analysis results are presented as interactive visualizations or can be exported as high-quality graphics and numerical tables which can be imported into common network analysis and visualization tools.
C1 [Grapov, Dmitry; Wanichthanarak, Kwanjeera; Fiehn, Oliver] Univ Calif Davis, NIH, West Coast Metabol Ctr, Davis, CA 95616 USA.
   [Grapov, Dmitry; Wanichthanarak, Kwanjeera; Fiehn, Oliver] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA.
   [Fiehn, Oliver] King Abdulaziz Univ, Dept Biochem, Jeddah 21413, Saudi Arabia.
RP Fiehn, O (reprint author), Univ Calif Davis, NIH, West Coast Metabol Ctr, Davis, CA 95616 USA.
EM ofiehn@ucdavis.edu
FU National Institutes of Health [NIH 1 U24 DK097154, NIH P20 HL113452]
FX This project was funded by the National Institutes of Health, NIH 1 U24
   DK097154 for the West Coast Metabolomics Center (OF, DG) and NIH P20
   HL113452 (OF).
NR 14
TC 16
Z9 16
U1 6
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1367-4803
EI 1460-2059
J9 BIOINFORMATICS
JI Bioinformatics
PD AUG 15
PY 2015
VL 31
IS 16
BP 2757
EP 2760
DI 10.1093/bioinformatics/btv194
PG 4
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
   Computer Science, Interdisciplinary Applications; Mathematical &
   Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Computer Science; Mathematical & Computational Biology; Mathematics
GA CP1WC
UT WOS:000359666600025
PM 25847005
ER

PT J
AU Burbach, JPH
   Hellemons, AJCGM
   Grant, P
   Pant, HC
AF Burbach, J. Peter H.
   Hellemons, Anita J. C. G. M.
   Grant, Philip
   Pant, Harish C.
TI The homeodomain transcription factor Phox2 in the stellate ganglion of
   the squid Loligo pealei
SO BIOLOGY OPEN
LA English
DT Article
DE Homeodomain transcription factors; Squid; Phox2; FMRFamide; Stellate
   ganglion; Squid giant axon; Brain development
ID DOPAMINE-BETA-HYDROXYLASE; GIANT NERVE-FIBERS; GENE-EXPRESSION; HOX
   GENES; NEURONS; SYSTEM; SPECIFICATION; ELEGANS; ORIGIN; DIFFERENTIATION
AB Homeodomain transcription factors regulate development of embryos and cellular physiology in adult systems. Paired-type homeodomain genes constitute a subclass that has been particularly implicated in establishment of neuronal identity in the mammalian nervous system. We isolated fragments of eight homeodomain genes of this subclass expressed in the stellate ganglion of the North Atlantic long finned squid Loligo pealei (lp) [Note: Loligo pealei has been officially renamed Doryteuthis pealei. For reasons of uniformity and clarity Loligo pealei (lp) is used here]. Of the most abundant ones, we cloned a full length cDNA which encoded the squid ortholog of the paired-type homeodomain proteins Phox2a/b. The homology of lpPhox2 to invertebrate and mammalian Phox2 was limited to the homeodomain. In contrast to mouse Phox2b, lpPhox2 was unable to transactivate the dopamine beta-hydroxylase (DBH) promoter in a heterologous mammalian transfection system. In vivo, lpPhox2 was expressed in the developing stellate ganglion of stage 27 squid embryos and continued to be expressed in the adult stellate neurons where expression was confined to the giant fiber lobe containing the neurons that form the giant axons. The expression of lpPhox was similarly timed and distributed as the Fmrf gene. Furthermore, the Fmrf upstream region contained putative Phox2a/b binding sites. These results suggest a role of lpPhox2 in the developmental specification of neuronal identity and regulation of neurons of the squid giant axon.
C1 [Burbach, J. Peter H.; Hellemons, Anita J. C. G. M.] Univ Utrecht, Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, NL-3584 CG Utrecht, Netherlands.
   [Burbach, J. Peter H.; Hellemons, Anita J. C. G. M.; Grant, Philip; Pant, Harish C.] Marine Biol Lab, Woods Hole, MA 02543 USA.
   [Grant, Philip; Pant, Harish C.] NINDS, Lab Neurochem, Bethesda, MD 20892 USA.
RP Burbach, JPH (reprint author), Univ Utrecht, Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, NL-3584 CG Utrecht, Netherlands.
EM j.p.h.burbach@umcutrecht.nl
FU David de Wied Foundation; Marine Biological Laboratory (MBL) Fellowships
   - Baxter Postdoctoral Fellowship Fund; MBL Associates Fund; James A. and
   Faith Miller Memorial Fund; H.B. Steinbach Fund; Hersenstichting
   Nederland; U.S. National Institutes of Health (NIH), NINDS. USA
FX This research was supported by the David de Wied Foundation and by two
   Marine Biological Laboratory (MBL) Fellowships (J.P.H.B.) sponsored by
   the Baxter Postdoctoral Fellowship Fund, MBL Associates Fund, James A.
   and Faith Miller Memorial Fund, the H.B. Steinbach Fund, the
   Hersenstichting Nederland (J.P.H.B.) and by the intramural research
   program of the U.S. National Institutes of Health (NIH), NINDS. USA.
NR 43
TC 0
Z9 0
U1 0
U2 0
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 2046-6390
J9 BIOL OPEN
JI Biol. Open
PD AUG 15
PY 2015
VL 4
IS 8
BP 954
EP 960
DI 10.1242/bio.012476
PG 7
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA CP1AM
UT WOS:000359608200003
PM 26116657
ER

PT J
AU Chandran, SS
   Paria, BC
   Srivastava, AK
   Rothermel, LD
   Stephens, DJ
   Kammula, US
AF Chandran, Smita S.
   Paria, Biman C.
   Srivastava, Abhishek K.
   Rothermel, Luke D.
   Stephens, Daniel J.
   Kammula, Udai S.
TI Tumor-Specific Effector CD8(+) T Cells That Can Establish Immunological
   Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7
   Receptor and c-myc
SO CANCER RESEARCH
LA English
DT Article
ID IN-VIVO; CANCER REGRESSION; TRANSFER THERAPY; STEM-CELLS;
   DIFFERENTIATION; IMMUNOTHERAPY; PROLIFERATION; PERSISTENCE; GENERATION;
   LYMPHOCYTES
AB The optimal T-cell attributes for adoptive cancer immunotherapy are unclear. Recent clinical trials of ex vivo-expanded tumor-infiltrating lymphocytes indicated that differentiated T effector cells can elicit durable antitumor responses in some patients with cancer, with their antitumor activity tightly correlated with their persistence in the host. Thus, there is great interest in the definition of intrinsic biomarkers that can predict the conversion of short-lived tumor antigen-specific T effector cells into long-lived T memory cells. Long-term persistence of ex vivo-expanded tumor-specific CD8(+) T effector clones has been reported in refractory metastatic melanoma patients after adoptive T-cell transfer. By using highly homogeneous clone populations from these preparations, we performed a comparative transcriptional profiling to define pre-infusion molecular attributes that can be ascribed to an effector-to-memory transition. Through this route, we discovered that preinfusion T-cell clones that expressed the IL7 receptor (IL7R) and c-myc were more likely to persist longer after adoptive transfer to patients. The predictive value of these two biomarkers was strengthened by using IL7R protein, IL7-induced pSTAT5, and c-myc mRNA expression to prospectively identify human tumor-specific T effector clones capable of engraftment into immunodeficient mice. Overall, our findings reveal IL7R and c-myc expression as intrinsic biomarkers that can predict the fate of CD8(+) T effector cells after adoptive transfer. (C) 2015 AACR.
C1 [Chandran, Smita S.; Paria, Biman C.; Srivastava, Abhishek K.; Rothermel, Luke D.; Stephens, Daniel J.; Kammula, Udai S.] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Kammula, US (reprint author), NCI, Surg Branch, Ctr Canc Res, 10 Ctr Dr,Bldg 10 Hatfield CRC,Room 3-5930, Bethesda, MD 20892 USA.
EM udai_kammula@nih.gov
RI Srivastava, Abhishek/M-7577-2014
FU Intramural Research Program of the NIH, NCI, Center for Cancer Research
FX This research was supported by the Intramural Research Program of the
   NIH, NCI, Center for Cancer Research.
NR 41
TC 4
Z9 4
U1 0
U2 5
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 15
PY 2015
VL 75
IS 16
BP 3216
EP 3226
DI 10.1158/0008-5472.CAN-15-0584
PG 11
WC Oncology
SC Oncology
GA CP0JR
UT WOS:000359562100004
PM 26100671
ER

PT J
AU Weinberger, DM
   Warren, JL
   Steiner, CA
   Charu, V
   Viboud, C
   Pitzer, VE
AF Weinberger, Daniel M.
   Warren, Joshua L.
   Steiner, Claudia A.
   Charu, Vivek
   Viboud, Cecile
   Pitzer, Virginia E.
TI Reduced-Dose Schedule of Prophylaxis Based on Local Data Provides
   Near-Optimal Protection Against Respiratory Syncytial Virus
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE RSV; respiratory syncytial virus; prophylaxis; palivizumab; spatial
   variation
ID UNITED-STATES; NATIONAL-SURVEILLANCE; COST-EFFECTIVENESS; PALIVIZUMAB;
   CHILDREN; INFANTS; RISK; HOSPITALIZATION; INFECTION; SEASON
AB Background. Respiratory syncytial virus (RSV) is a major cause of respiratory infections among young children and can lead to severe disease among some infants. Infants at high risk for severe RSV infection receive monthly injections of a prophylactic monoclonal antibody during the RSV season based on national guidelines. We considered whether a reduced-dose schedule tailored to the local RSV season in the continental United States would provide adequate protection.
   Methods. Hospitalization data for 1942 counties across 38 states from 1997 to 2009 were obtained from the State Inpatient Databases (Agency for Healthcare Research and Quality). We assessed the timing of RSV epidemics at the county and state levels using a 2-stage hierarchical Bayesian change point model. We used a simple summation approach to estimate the fraction of RSV cases that occur during the window of protection provided by initiating RSV prophylaxis during different weeks of the year.
   Results. The timing of RSV epidemic onset varied significantly at the local level. Nevertheless, the national recommendations for initiation of prophylaxis provided near-optimal coverage of the RSV season in most of the continental United States. Reducing from 5 to 4 monthly doses (with a later initiation) provides near-optimal coverage (<5% decrease in coverage) in most settings. Earlier optimal dates for initiating 4 doses of prophylaxis were associated with being farther south and east, higher population density, and having a higher percentage of the population that was black or Hispanic.
   Conclusions. A 4-dose schedule of prophylactic injections timed with local RSV epidemics could provide
C1 [Weinberger, Daniel M.; Pitzer, Virginia E.] Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06520 USA.
   [Warren, Joshua L.] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT 06520 USA.
   [Steiner, Claudia A.] Agcy Healthcare Res & Qual, Healthcare Cost & Utilizat Project, Ctr Delivery Org & Markets, Rockville, MD USA.
   [Charu, Vivek; Viboud, Cecile] NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Weinberger, DM (reprint author), Yale Univ, Dept Epidemiol Microbial Dis, POB 208034, New Haven, CT 06520 USA.
EM daniel.weinberger@yale.edu
OI Pitzer, Virginia/0000-0003-1015-2289; Weinberger,
   Daniel/0000-0003-1178-8086
FU Bill & Melinda Gates Foundation; Pfizer; Division of International
   Epidemiology and Population Studies; Fogarty International Center,
   National Institutes of Health (NIH); RAPIDD program of the Science and
   Technology Directorate, Department of Homeland Security;  [UL1TR000142]
FX C. V. was supported by the Division of International Epidemiology and
   Population Studies, Fogarty International Center, National Institutes of
   Health (NIH). V. E. P. was supported by the Bill & Melinda Gates
   Foundation and the RAPIDD program of the Science and Technology
   Directorate, Department of Homeland Security, and the Fogarty
   International Center, NIH. D. M. W. is a Pepper Scholar with support
   from the Claude D. Pepper Older Americans Independence Center at Yale
   University School of Medicine (grant number P30AG021342 NIH/National
   Institute on Aging), and acknowledges support from UL1TR000142 as well
   as support from the Bill & Melinda Gates Foundation and Pfizer.
NR 23
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 15
PY 2015
VL 61
IS 4
BP 506
EP 514
DI 10.1093/cid/civ331
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CO7MT
UT WOS:000359344200005
PM 25904370
ER

PT J
AU Kadri, SS
   Rhee, C
   Fortna, GS
   O'Grady, NP
AF Kadri, Sameer S.
   Rhee, Chanu
   Fortna, Gregory S.
   O'Grady, Naomi P.
TI Critical Care Medicine and Infectious Diseases: An Emerging Combined
   Subspecialty in the United States
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Editorial Material
DE critical care; infectious disease; fellowship
ID STAPHYLOCOCCUS-AUREUS BACTEREMIA; EBOLA-VIRUS DISEASE; ANTIMICROBIAL
   THERAPY; SEVERE SEPSIS; SEPTIC SHOCK; CONSULTATION; MANAGEMENT;
   OUTCOMES; IMPACT; APPROPRIATENESS
AB The recent rise in unfilled training positions among infectious diseases (ID) fellowship programs nationwide indicates that ID is declining as a career choice among internal medicine residency graduates. Supplementing ID training with training in critical care medicine (CCM) might be a way to regenerate interest in the specialty. Hands-on patient care and higher salaries are obvious attractions. High infection prevalence and antibiotic resistance in intensive care units, expanding immunosuppressed host populations, and public health crises such as the recent Ebola outbreak underscore the potential synergy of CCM-ID training. Most intensivists receive training in pulmonary medicine and only 1% of current board-certified intensivists are trained in ID. While still small, this cohort of CCM-ID certified physicians has continued to rise over the last 2 decades. ID and CCM program leadership nationwide must recognize these trends and the merits of the CCM-ID combination to facilitate creation of formal dual-training opportunities.
C1 [Kadri, Sameer S.; O'Grady, Naomi P.] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA.
   [Rhee, Chanu] Harvard Univ, Sch Med, Dept Populat Med, Cambridge, MA 02138 USA.
   [Rhee, Chanu] Harvard Pilgrim Hlth Care Inst, Boston, MA USA.
   [Rhee, Chanu] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA.
   [Fortna, Gregory S.] Amer Board Internal Med, Philadelphia, PA USA.
RP Kadri, SS (reprint author), NIH, Ctr Clin, Dept Crit Care Med, 10 Ctr Dr,Bldg 10,2C-145, Bethesda, MD 20892 USA.
EM sameer.kadri@nih.gov
FU Intramural NIH HHS; NIAID NIH HHS [T32 AI007061]
NR 39
TC 4
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U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 15
PY 2015
VL 61
IS 4
BP 609
EP 614
DI 10.1093/cid/civ360
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CO7MT
UT WOS:000359344200019
PM 25944345
ER

PT J
AU Sidharthan, S
   Kohli, A
   Kottilil, S
AF Sidharthan, Sreetha
   Kohli, Anita
   Kottilil, Shyam
TI Hepatitis C Virus RNA Levels During Interferon-Free Combination
   Direct-Acting Antiviral Treatment in Registrational Trials Reply
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Letter
ID GENOTYPE 1 INFECTION; RIBAVIRIN
C1 [Sidharthan, Sreetha; Kohli, Anita] NIH, Crit Care Med Dept, Natl Inst Hlth Clin Ctr, Bethesda, MD 20892 USA.
   [Kottilil, Shyam] Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA.
   [Kottilil, Shyam] NIH, Lab Immunoregulat, Natl Inst Allergy & Infect Dis, Bethesda, MD 20892 USA.
RP Kottilil, S (reprint author), Inst Human Virol, Rm S222,725 Lombard St, Baltimore, MD 21201 USA.
EM skottilil@ihv.umaryland.edu
NR 5
TC 1
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U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 15
PY 2015
VL 61
IS 4
BP 667
EP 668
DI 10.1093/cid/civ403
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CO7MT
UT WOS:000359344200032
PM 26002847
ER

PT J
AU Perkins, MR
   Bartha, I
   Timmer, JK
   Liebner, JC
   Wollinsky, D
   Gunthard, HF
   Hauser, C
   Bernasconi, E
   Hoffmann, M
   Calmy, A
   Battegay, M
   Telenti, A
   Douek, DC
   Fellay, J
AF Perkins, Molly R.
   Bartha, Istvan
   Timmer, J. Katherina
   Liebner, Julia C.
   Wollinsky, David
   Guenthard, Huldrych F.
   Hauser, Christoph
   Bernasconi, Enos
   Hoffmann, Matthias
   Calmy, Alexandra
   Battegay, Manuel
   Telenti, Amalio
   Douek, Daniel C.
   Fellay, Jacques
CA Swiss HIV Cohort Study
TI The Interplay Between Host Genetic Variation, Viral Replication, and
   Microbial Translocation in Untreated HIV-Infected Individuals
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE HIV; host genomics; genome-wide association study; immune activation;
   microbial translocation; sCD14; I-FABP
ID GENOME-WIDE ASSOCIATION; IMMUNE ACTIVATION; PREDICT MORTALITY;
   PATHOGENESIS; POLYMORPHISM; PROGRESSION; HAPLOTYPES; AIDS
AB Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal damage. Although human genetic variants influencing HIV load have been identified, it is unknown how much the host genetic background contributes to interindividual differences in other determinants of HIV pathogenesis such as gut damage and microbial translocation. Using samples and data from 717 untreated participants in the Swiss HIV Cohort Study and a genome-wide association study design, we searched for human genetic determinants of plasma levels of intestinal fatty acid-binding protein (I-FABP/FABP2), a marker of gut damage, and of soluble CD14 (sCD14), a marker of lipopolysaccharide bioactivity and microbial translocation. We also assessed the correlations between HIV load, sCD14, and I-FABP. Although we found no genome-wide significant determinant of the tested plasma markers, we observed strong associations between sCD14 and both HIV load and I-FABP, shedding new light on the relationships between processes that drive progression of untreated HIV infection.
C1 [Perkins, Molly R.; Timmer, J. Katherina; Liebner, Julia C.; Wollinsky, David; Douek, Daniel C.] NIAID, Vaccine Res Ctr, Human Immunol Sect, NIH, Bethesda, MD 20892 USA.
   [Bartha, Istvan; Fellay, Jacques] Ecole Polytech Fed Lausanne, Sch Life Sci, Global Hlth Inst, CH-1015 Lausanne, Switzerland.
   [Perkins, Molly R.; Fellay, Jacques] Swiss Inst Bioinformat, Lausanne, Switzerland.
   [Bartha, Istvan; Telenti, Amalio] Univ Lausanne, CH-1015 Lausanne, Switzerland.
   [Guenthard, Huldrych F.] Univ Zurich Hosp, Div Infect Dis, Zurich, Switzerland.
   [Guenthard, Huldrych F.] Univ Zurich Hosp, Hosp Epidemiol, Zurich, Switzerland.
   [Guenthard, Huldrych F.] Univ Zurich, CH-8006 Zurich, Switzerland.
   [Hauser, Christoph] Univ Hosp Bern, Univ Clin Infect Dis, Bern, Switzerland.
   [Hauser, Christoph] Univ Bern, CH-3012 Bern, Switzerland.
   [Bernasconi, Enos] Reg Hosp Lugano, Div Infect Dis, Lugano, Switzerland.
   [Hoffmann, Matthias] Cantonal Hosp St Gallen, Div Infect Dis, St Gallen, Switzerland.
   [Hoffmann, Matthias] Cantonal Hosp St Gallen, Hosp Epidemiol, St Gallen, Switzerland.
   [Calmy, Alexandra] Univ Hosp Geneva, Dept Internal Med, HIV Unit, Geneva, Switzerland.
   [Battegay, Manuel] Univ Basel, Univ Basel Hosp, Div Infect Dis, CH-4003 Basel, Switzerland.
   [Battegay, Manuel] Univ Basel, Univ Basel Hosp, Hosp Epidemiol, Dept Clin, CH-4003 Basel, Switzerland.
   [Battegay, Manuel] Univ Basel, Univ Basel Hosp, Dept Biomed Res, CH-4003 Basel, Switzerland.
RP Fellay, J (reprint author), Ecole Polytech Fed Lausanne, Sch Life Sci, Stn 19, CH-1015 Lausanne, Switzerland.
EM jacques.fellay@epfl.ch
RI SHCS, all/G-4072-2011; SHCS, only/G-4080-2011; SHCS, ch/G-4077-2011;
   Infektiologie, USZ/A-6921-2011; Pantaleo, Giuseppe/K-6163-2016;
   gunthard, huldrych/F-1724-2011; Fellay, Jacques/A-6681-2009; 
OI gunthard, huldrych/0000-0002-1142-6723; Fellay,
   Jacques/0000-0002-8240-939X; Hauser, Christoph/0000-0002-2413-8931
FU SHCS - Swiss National Science Foundation [134277, 148522]; SHCS [617];
   Swiss National Science Foundation [PP00P3_133703]
FX This work was financed within the framework of the SHCS, supported by
   the Swiss National Science Foundation (grants 134277 and 148522) and by
   SHCS project 617. J. F. is also supported by the Swiss National Science
   Foundation (professorship grant PP00P3_133703).
NR 25
TC 6
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U1 1
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 15
PY 2015
VL 212
IS 4
BP 578
EP 584
DI 10.1093/infdis/jiv089
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CP1ZW
UT WOS:000359677600010
PM 25701868
ER

PT J
AU von Stockenstrom, S
   Odevall, L
   Lee, E
   Sinclair, E
   Bacchetti, P
   Killian, M
   Epling, L
   Shao, W
   Hoh, R
   Ho, T
   Faria, NR
   Lemey, P
   Albert, J
   Hunt, P
   Loeb, L
   Pilcher, C
   Poole, L
   Hatano, H
   Somsouk, M
   Douek, D
   Boritz, E
   Deeks, SG
   Hecht, FM
   Palmer, S
AF von Stockenstrom, Susanne
   Odevall, Lina
   Lee, Eunok
   Sinclair, Elizabeth
   Bacchetti, Peter
   Killian, Maudi
   Epling, Lorrie
   Shao, Wei
   Hoh, Rebecca
   Ho, Terence
   Faria, Nuno R.
   Lemey, Philippe
   Albert, Jan
   Hunt, Peter
   Loeb, Lisa
   Pilcher, Christopher
   Poole, Lauren
   Hatano, Hiroyu
   Somsouk, Ma
   Douek, Daniel
   Boritz, Eli
   Deeks, Steven G.
   Hecht, Frederick M.
   Palmer, Sarah
TI Longitudinal Genetic Characterization Reveals That Cell Proliferation
   Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE HIV-1 persistence; HIV-1 reservoir; memory T cells
ID SUPPRESSIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; MEMORY; SITES;
   INTENSIFICATION; INFECTION; RESERVOIR; SURVIVAL; MULTIPLE; DRIVEN
AB Background. The stability of the human immunodeficiency virus type 1 (HIV-1) reservoir and the contribution of cellular proliferation to the maintenance of the reservoir during treatment are uncertain. Therefore, we conducted a longitudinal analysis of HIV-1 in T-cell subsets in different tissue compartments from subjects receiving effective antiretroviral therapy (ART).
   Methods. Using single-proviral sequencing, we isolated intracellular HIV-1 genomes derived from defined subsets of CD4+ T cells from peripheral blood, gut-associated lymphoid tissue and lymph node tissue specimens from 8 subjects with virologic suppression during long-term ART at 2 time points (time points 1 and 2) separated by 7-9 months.
   Results. DNA integrant frequencies were stable over time (<4-fold difference) and highest in memory T cells. Phylogenetic analyses showed that subjects treated during chronic infection contained viral populations with up to 73% identical sequence expansions, only 3 of which were observed in specimens obtained before therapy. At time points 1 and 2, such clonally expanded populations were found predominantly in effector memory T cells from peripheral blood and lymph node tissue specimens.
   Conclusions. Memory T cells maintained a relatively constant HIV-1 DNA integrant pool that was genetically stable during long-term effective ART. These integrants appear to be maintained by cellular proliferation and longevity of infected cells, rather than by ongoing viral replication.
C1 [von Stockenstrom, Susanne; Odevall, Lina; Albert, Jan; Palmer, Sarah] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.
   [von Stockenstrom, Susanne; Albert, Jan] Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
   [Lee, Eunok; Palmer, Sarah] Westmead Millennium Inst Med Res, Westmead, NSW, Australia.
   [Lee, Eunok; Palmer, Sarah] Univ Sydney, Westmead, NSW 2145, Australia.
   [Sinclair, Elizabeth; Killian, Maudi; Epling, Lorrie; Hoh, Rebecca; Ho, Terence; Hunt, Peter; Loeb, Lisa; Pilcher, Christopher; Poole, Lauren; Hatano, Hiroyu; Somsouk, Ma; Deeks, Steven G.; Hecht, Frederick M.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Bacchetti, Peter] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Shao, Wei] Leidos Biomedical Res INC, Frederick Natl Lab Canc Res, Bethesda, MD USA.
   [Douek, Daniel; Boritz, Eli] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Faria, Nuno R.; Lemey, Philippe] Univ Leuven, KU Leuven, Rega Inst, Dept Microbiol & Immunol, Leuven, Belgium.
RP von Stockenstrom, S (reprint author), Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.
EM susanne.vonstockenstrom@ki.se
OI Faria, Nuno/0000-0001-8839-2798
FU Foundation for AIDS Research (amfAR Research Consortium on HIV
   Eradication Collaborative research grant) [108074-50-RGRL]; Delaney AIDS
   Research Enterprise [U19 AI096109]; Australian National Health and
   Medical Research Council [AAP1061681]; Erik and Edith Fernstrom
   Foundation for Medical Research; Karolinska Institutet
FX This work was supported by the Foundation for AIDS Research (amfAR
   Research Consortium on HIV Eradication Collaborative research grant
   108074-50-RGRL), Delaney AIDS Research Enterprise (U19 AI096109), the
   Australian National Health and Medical Research Council (AAP1061681),
   the Erik and Edith Fernstrom Foundation for Medical Research (to S. v.
   S.), and the Karolinska Institutet (alumni funds to S. v. S.).
NR 18
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U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 15
PY 2015
VL 212
IS 4
BP 596
EP 607
DI 10.1093/infdis/jiv092
PG 12
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CP1ZW
UT WOS:000359677600012
PM 25712966
ER

PT J
AU Sonden, K
   Doumbo, S
   Hammar, U
   Homann, MV
   Ongoiba, A
   Traore, B
   Bottai, M
   Crompton, PD
   Farnert, A
AF Sonden, Klara
   Doumbo, Safiatou
   Hammar, Ulf
   Homann, Manijeh Vafa
   Ongoiba, Aissata
   Traore, Boubacar
   Bottai, Matteo
   Crompton, Peter D.
   Farnert, Anna
TI Asymptomatic Multiclonal Plasmodium falciparum Infections Carried
   Through the Dry Season Predict Protection Against Subsequent Clinical
   Malaria
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE immunity; P. falciparum; msp2; genotyping; malaria; children
ID SICKLE-CELL TRAIT; ANTIBODY-RESPONSES; PYROGENIC THRESHOLD; TANZANIAN
   CHILDREN; GENETIC DIVERSITY; REDUCED RISK; ENDEMIC AREA; TRANSMISSION;
   DISEASE; PARASITEMIA
AB Background. Immunity to the antigenically diverse parasite Plasmodium falciparum is acquired gradually after repeated exposure. Studies in areas of high malaria transmission have shown that asymptomatic individuals infected with multiclonal infections are at reduced risk of febrile malaria during follow-up.
   Methods. We assessed the relationship between the genetic diversity of clones in P. falciparum infections that persist through the dry season and the subsequent risk of febrile malaria in 225 individuals aged 2-25 years in Mali, where the 6-month malaria and dry seasons are sharply demarcated. Polymerase chain reaction-based genotyping of the highly polymorphic merozoite surface protein 2 gene was performed on blood samples collected at 5 cross-sectional surveys.
   Results. In an age-adjusted analysis, individuals with multiclonal P. falciparum infections before the rainy season were at reduced risk of febrile malaria, compared with individuals who were uninfected (hazard ratio [HR], 0.28; 95% confidence interval [CI], .11-.69). In contrast, there was no significant association between risk of malaria and having 1 clone at baseline (HR, 0.71; 95% CI, .36-1.40).
   Conclusions. The results suggest that persistent multiclonal infections carried through the dry season contribute to protection against subsequent febrile malaria, possibly by maintaining protective immune responses that depend on ongoing parasite infection.
C1 [Sonden, Klara; Homann, Manijeh Vafa; Farnert, Anna] Karolinska Inst, Unit Infect Dis, Dept Med Solna, Inst Environm, S-17176 Stockholm, Sweden.
   [Hammar, Ulf; Ongoiba, Aissata; Bottai, Matteo] Karolinska Inst, Inst Environm Med, Dept Epidemiol, Unit Biostat, S-17176 Stockholm, Sweden.
   [Doumbo, Safiatou; Ongoiba, Aissata; Traore, Boubacar] Univ Sci Tech & Technol Bamako, Mali Int Ctr Excellence Res, Bamako, Mali.
   [Crompton, Peter D.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
RP Sonden, K (reprint author), Karolinska Inst, Unit Infect Dis, Dept Med, S-17176 Stockholm, Sweden.
EM klara.sonden@ki.se
RI Crompton, Peter/N-1130-2016
FU Marianne and Marcus Wallenberg Foundation; Swedish Research Council;
   Karolinska University Hospital; Division of Intramural Research,
   National Institute of Allergy and Infectious Diseases, National
   Institutes of Health
FX This work was supported by the Marianne and Marcus Wallenberg
   Foundation, the Swedish Research Council, Karolinska University Hospital
   (research/clinical internship to K. S.), and the Division of Intramural
   Research, National Institute of Allergy and Infectious Diseases,
   National Institutes of Health (for the cohort study in Mali).
NR 38
TC 4
Z9 4
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 15
PY 2015
VL 212
IS 4
BP 608
EP 616
DI 10.1093/infdis/jiv088
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CP1ZW
UT WOS:000359677600013
PM 25712968
ER

PT J
AU Burotto, M
   Prasad, V
AF Burotto, Mauricio
   Prasad, Vinay
TI Emphasizing Unique Strengths and Eliminating Redundancy for Research in
   Low-Income and Middle-Income Countries: Lessons From a South American
   Country
SO CANCER
LA English
DT Editorial Material
C1 [Burotto, Mauricio; Prasad, Vinay] NCI, Med Oncol Serv, NIH, Bethesda, MD 20892 USA.
RP Burotto, M (reprint author), NCI, Med Oncol Serv, NIH, 10 Ctr Dr,10-12N226, Bethesda, MD 20892 USA.
EM mauricioburotto@yahoo.com
OI Prasad, Vinay/0000-0002-6110-8221
NR 8
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD AUG 15
PY 2015
VL 121
IS 16
BP 2668
EP 2670
DI 10.1002/cncr.29408
PG 3
WC Oncology
SC Oncology
GA CO5HO
UT WOS:000359190400004
PM 25903222
ER

PT J
AU Kenzik, KM
   Ganz, PA
   Martin, MY
   Petersen, L
   Hays, RD
   Arora, N
   Pisu, M
AF Kenzik, Kelly M.
   Ganz, Patricia A.
   Martin, Michelle Y.
   Petersen, Laura
   Hays, Ron D.
   Arora, Neeraj
   Pisu, Maria
TI How Much Do Cancer-Related Symptoms Contribute to Health-Related Quality
   of Life in Lung and Colorectal Cancer Patients? A Report From the Cancer
   Care Outcomes Research and Surveillance (CanCORS) Consortium
SO CANCER
LA English
DT Article
DE cancer; colorectal; lung; health-related quality of life; symptoms
ID RANDOMIZED CONTROLLED-TRIALS; PALLIATIVE-CARE; CLINICAL-TRIALS;
   ONCOLOGY; CONSTRUCTION; SURVIVORS; SOCIETY; QLQ-C30; ISSUES
AB BACKGROUND: The objective of this study was to examine associations of symptoms with physical and mental health-related quality of life (HRQOL) in patients with colorectal cancer (CRC) and in patients with lung cancer. METHODS: Patients with newly diagnosed CRC (n=3040) or lung cancer (n=2297) who were participating in the Cancer Care Outcomes Research and Surveillance Consortium study completed surveys on general HRQOL and symptoms. HRQOL was measured by using physical component summary (PCS) and mental component summary (MCS) scores on the Medical Outcomes Study 12-item short-form heath survey. Nonspecific cancer symptoms were measured using items from the European Organization for Research and Treatment of Cancer core quality-oflife questionnaire. Cancer type-specific modules developed by the European Organization for Research and Treatment of Cancer were used to assess CRC-specific and lung cancer-specific symptoms. For both cancer types, linear regression models that were controlled for demographic and clinical information were used to examine correlations of nonspecific and cancer-specific symptoms with PCS and MCS scores. RESULTS: PCS scores for patients with CRC and lung cancer were below the general population norm of 50 (43 and 37, respectively), and MCS scores were at the population norm. For the CRC sample, in the model that included both symptom indices, an increase in nonspecific symptoms was more strongly associated with lower PCS and MCS scores than an increase in CRC-specific symptoms (PCS, standardized coefficient [beta] = -0.41 vs -0.09; MCS, beta = -0.38 vs -0.08). In a similar model for lung cancer, increases in lung cancer-specific symptoms were more strongly associated with lower PCS scores (beta = -0.34 vs -0.20), whereas nonspecific symptoms were more strongly associated with lower MCS scores (beta = -0.34 vs -0.14). CONCLUSIONS: Symptoms were associated with HRQOL impairments in recently diagnosed patients. Additional supportive care implemented early in cancer care, regardless of cancer stage, may provide symptom relief and improve HRQOL (C) 2015 American Cancer Society.
C1 [Kenzik, Kelly M.; Martin, Michelle Y.; Pisu, Maria] Univ Alabama Birmingham, Sch Med, Birmingham, AL 35233 USA.
   [Ganz, Patricia A.; Petersen, Laura; Hays, Ron D.] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Los Angeles, CA USA.
   [Ganz, Patricia A.; Hays, Ron D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Hays, Ron D.] RAND Corp, Santa Monica, CA USA.
   [Arora, Neeraj] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
RP Kenzik, KM (reprint author), Univ Alabama Birmingham, Ctr Outcomes & Effectiveness Res, MT521, Birmingham, AL 35233 USA.
EM kellykenzik@uabmc.edu
FU National Cancer Institute [U01 CA093344]; Primary Data Collection and
   Research Centers at Harvard Medical School and Northern California
   Cancer Center [U01 CA093324]; Dana-Farber Cancer Institute and Cancer
   Research Network [U01 CA093332]; RAND and the University of California,
   Los Angeles [U01 CA093348]; University of Alabama at Birmingham [U01
   CA093329]; University of Iowa [U01 CA01013]; University of North
   Carolina [U01 CA093326]; Department of Veterans Affairs (VA) grant [U01
   CDA093344[MOU], HARQ 03-438MO-03]; National Institute on Aging
   [P30AG021684]; National Institute for Minority Health and Health
   Disparities [2P20MD000182]; Agency for Healthcare Research and Quality
   [2 T32 HS013852]
FX The Cancer Care Outcomes Research and Surveillance (Can-CORS) Consortium
   was supported by grants from the National Cancer Institute to the
   Statistical Coordinating Center at Dana-Farber Cancer Institute (U01
   CA093344) and the Primary Data Collection and Research Centers at
   Harvard Medical School and Northern California Cancer Center (U01
   CA093324); Dana-Farber Cancer Institute and Cancer Research Network (U01
   CA093332); RAND and the University of California, Los Angeles(U01
   CA093348); the University of Alabama at Birmingham (U01 CA093329); the
   University of Iowa (U01 CA01013); and the University of North Carolina
   (U01 CA093326); and by a Department of Veterans Affairs (VA) grant to
   Durham VA Medical Center (U01 CDA093344[ MOU] and HARQ 03-438MO-03). Dr.
   Hays was supported in part by funding from the National Institute on
   Aging (P30AG021684) and the National Institute for Minority Health and
   Health Disparities (2P20MD000182). Dr. Kenzik was supported by grant 2
   T32 HS013852 from the Agency for Healthcare Research and Quality.
NR 31
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U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD AUG 15
PY 2015
VL 121
IS 16
BP 2831
EP 2839
DI 10.1002/cncr.29415
PG 9
WC Oncology
SC Oncology
GA CO5HO
UT WOS:000359190400025
PM 25891437
ER

PT J
AU Souza, PS
   Madigan, JP
   Gillet, JP
   Kapoor, K
   Ambudkar, SV
   Maia, RC
   Gottesman, MM
   Fung, KL
AF Souza, Paloma S.
   Madigan, James P.
   Gillet, Jean-Pierre
   Kapoor, Khyati
   Ambudkar, Suresh V.
   Maia, Raquel C.
   Gottesman, Michael M.
   Fung, King Leung
TI Expression of the multidrug transporter P-glycoprotein is inversely
   related to that of apoptosis-associated endogenous TRAIL
SO EXPERIMENTAL CELL RESEARCH
LA English
DT Article
DE ABCB1; MDR1; TRAIL; apoptosis; TET-Off; multidrug resistance; TNESF10
ID CANCER-CELLS; TRANSCRIPTIONAL REGULATION; DEFICIENT MICE; LIGAND TRAIL;
   RESISTANCE; DEATH; GENE; NEUTROPHILS; TUMORS; ABCB1
AB Multidrug resistance (MDR) has been associated with expression of ABC transporter genes including P-glycoprotein (Pgp, MDR1, ABCB1). However, deregulation of apoptotic pathways also renders cells resistant to chemotherapy. To discover apoptosis-related genes affected by Pgp expression, we used the HeLa MDR-off system. We found that using doxycycline to control Pgp expression has a significant advantage over tetracycline, in that doxycycline caused less endogenous gene expression modification/ perturbation, and was more potent than tetracycline in suppressing Pgp expression. Cells overexpressing Pgp have lower TNFSF10 (TRAIL) expression than their parental cells. Controlled downregulation of Pgp increased endogenous TRAIL protein expression. Also, ectopic overexpression of TRAIL in Pgp-positive cells was associated with a reduction in Pgp levels. However, cells expressing a functionally defective mutant Pgp showed an increase in TRAIL expression, suggesting that Pgp function is required for TRAIL suppression. Cells in which Pgp is knocked down by upregulation of TRAIL expression are less susceptible to TRAIL ligand (sTRAIL)-induced apoptosis. Our findings reveal an inverse correlation between functional Pgp and endogenous TRAIL expression. Pgp function plays an important role in the TRAIL-mediated apoptosis pathway by regulating endogenous TRAIL expression and the TRAIL-mediated apoptosis pathway in MDR cancer cells. Published by Elsevier Inc.
C1 [Souza, Paloma S.; Madigan, James P.; Gillet, Jean-Pierre; Kapoor, Khyati; Ambudkar, Suresh V.; Gottesman, Michael M.; Fung, King Leung] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Souza, Paloma S.; Maia, Raquel C.] Inst Nacl Canc INCA, Lab Hematooncol Celular & Mol, Programa Pesquisa Hematooncol Mol, Rio De Janeiro, Brazil.
RP Gottesman, MM (reprint author), NCI, Cell Biol Lab, Ctr Canc Res, NIH, 37 Convent Dr,Room 2108, Bethesda, MD 20892 USA.
EM mgottesman@nih.gov
RI maia, raquel/L-4869-2015; Silva  de Souza, Paloma/C-3091-2015
OI maia, raquel/0000-0003-0225-471X; Silva  de Souza,
   Paloma/0000-0002-1360-1134
FU Intramural Research Program of the National Institutes of Health
   (National Cancer Institute); CNPq; Fundacao de Amparo a Pesquisa do Rio
   de Janeiro (FAPERJ)
FX This research was supported by the Intramural Research Program of the
   National Institutes of Health (National Cancer Institute), CNPq, and
   Fundacao de Amparo a Pesquisa do Rio de Janeiro (FAPERJ). We thank Dr.
   Matthew Hall for constructive criticism of the manuscript and George
   Leiman for editorial assistance.
NR 42
TC 5
Z9 5
U1 3
U2 8
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4827
EI 1090-2422
J9 EXP CELL RES
JI Exp. Cell Res.
PD AUG 15
PY 2015
VL 336
IS 2
BP 318
EP 328
DI 10.1016/j.yexcr.2015.06.005
PG 11
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA CO5ET
UT WOS:000359183100015
PM 26101157
ER

PT J
AU Zhao, X
   Ueda, Y
   Kajigaya, S
   Alaks, G
   Desierto, MJ
   Townsley, DM
   Dumitriu, B
   Chen, JC
   Lacy, RC
   Young, NS
AF Zhao, Xin
   Ueda, Yasutaka
   Kajigaya, Sachiko
   Alaks, Glen
   Desierto, Marie J.
   Townsley, Danielle M.
   Dumitriu, Bogdan
   Chen, Jichun
   Lacy, Robert C.
   Young, Neal S.
TI Cloning and molecular characterization of telomerase reverse
   transcriptase (TERT) and telomere length analysis of Peromyscus leucopus
SO GENE
LA English
DT Article
DE TERT mutation; Ribosomal protein; Large; PO (RPLPO); Cloning
ID RIBOSOMAL P-PROTEINS; CATALYTIC SUBUNIT; MOUSE TELOMERASE;
   CELL-DIFFERENTIATION; GENES; IDENTIFICATION; EXPRESSION; MICE; RAT;
   PROLIFERATION
AB Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase complex that regulates telomerase activity to maintain telomere length for all animals with linear chromosomes. As the Mus musculus (MM) laboratory mouse has very long telomeres compared to humans, a potential alternative animal model for telomere research is the Peromyscus leucopus (PL) mouse that has telomere lengths close to the human range and has the wild counterparts for comparison. We report the full TERT coding sequence (pTERT) from PL mice to use in the telomere research. Comparative analysis with eight other mammalian TERTs revealed a pTERT protein considerably homologous to other TERTs and preserved all TERT specific-sequence signatures, yet with some distinctive features. pTERT displayed the highest nucleotide and amino acid sequence homology with hamster TERT. Unlike human but similar to MM mice, pTERT expression was detected in various adult somatic tissues of PL mice, with the highest expression in testes. Four different captive stocks of PL mice and wild-captured PL mice each displayed group-specific average telomere lengths, with the longest and shortest telomeres in inbred and outbred stock mice, respectively. pTERT showed considerable numbers of synonymous and nonsynonymous mutations. A pTERT proximal promoter region cloned was homologous among PL and MM mice and rat, but with species-specific features. From PL mice, we further cloned and characterized ribosomal protein, large, PO (pRPLPO) to use as an internal control for various assays. Peromyscus mice have been extensively used for various studies, including human diseases, for which pTERT and pRPLPO would be useful tools. Published by Elsevier B.V.
C1 [Zhao, Xin; Ueda, Yasutaka; Kajigaya, Sachiko; Desierto, Marie J.; Townsley, Danielle M.; Dumitriu, Bogdan; Chen, Jichun; Young, Neal S.] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA.
   [Alaks, Glen; Lacy, Robert C.] Chicago Zool Soc, Dept Conservat Sci, Brookfield, IL USA.
RP Zhao, X (reprint author), NHLBI, Hematol Branch, NIH, Bldg 10-CRC,Rm 3E-5232,10 Ctr Dr,9000 Rockville, Bethesda, MD 20892 USA.
EM zhaox10@nhlbi.nih.gov
FU National Heart, Lung, and Blood Institute
FX This research was supported by the Intramural Research Program of
   National Heart, Lung, and Blood Institute.
NR 48
TC 0
Z9 0
U1 1
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD AUG 15
PY 2015
VL 568
IS 1
BP 8
EP 18
DI 10.1016/j.gene.2015.05.013
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA CM1KE
UT WOS:000357439000002
PM 25962353
ER

PT J
AU Pfeiffer, RM
   Riedl, R
AF Pfeiffer, R. M.
   Riedl, R.
TI On the use and misuse of scalar scores of confounders in design and
   analysis of observational studies
SO STATISTICS IN MEDICINE
LA English
DT Article
DE misspecified models; matched case-control study; summary scores;
   confounder scores; balancing scores; treatment effect
ID MAXIMUM-LIKELIHOOD-ESTIMATION; DISEASE RISK SCORES; PROPENSITY-SCORE;
   REGRESSION; STRATIFICATION; MULTIVARIATE; POPULATION; COHORT
AB We assess the asymptotic bias of estimates of exposure effects conditional on covariates when summary scores of confounders, instead of the confounders themselves, are used to analyze observational data. First, we study regression models for cohort data that are adjusted for summary scores. Second, we derive the asymptotic bias for case-control studies when cases and controls are matched on a summary score, and then analyzed either using conditional logistic regression or by unconditional logistic regression adjusted for the summary score. Two scores, the propensity score (PS) and the disease risk score (DRS) are studied in detail. For cohort analysis, when regression models are adjusted for the PS, the estimated conditional treatment effect is unbiased only for linear models, or at the null for non-linear models. Adjustment of cohort data for DRS yields unbiased estimates only for linear regression; all other estimates of exposure effects are biased. Matching cases and controls on DRS and analyzing them using conditional logistic regression yields unbiased estimates of exposure effect, whereas adjusting for the DRS in unconditional logistic regression yields biased estimates, even under the null hypothesis of no association. Matching cases and controls on the PS yield unbiased estimates only under the null for both conditional and unconditional logistic regression, adjusted for the PS. We study the bias for various confounding scenarios and compare our asymptotic results with those from simulations with limited sample sizes. To create realistic correlations among multiple confounders, we also based simulations on a real dataset. Copyright (c) 2015John Wiley & Sons, Ltd.
C1 [Pfeiffer, R. M.] NCI, Bethesda, MD 20892 USA.
   [Riedl, R.] Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria.
RP Pfeiffer, RM (reprint author), NCI, Bethesda, MD 20892 USA.
EM pfeiffer@mail.nih.gov
NR 31
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-6715
EI 1097-0258
J9 STAT MED
JI Stat. Med.
PD AUG 15
PY 2015
VL 34
IS 18
BP 2618
EP 2635
DI 10.1002/sim.6467
PG 18
WC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Medicine, Research &
   Experimental; Statistics & Probability
SC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Research & Experimental
   Medicine; Mathematics
GA CM1GE
UT WOS:000357428500003
PM 25781579
ER

PT J
AU Ma, J
   Zhao, HY
   Schuck, P
AF Ma, Jia
   Zhao, Huaying
   Schuck, Peter
TI A histogram approach to the quality of fit in sedimentation velocity
   analyses
SO ANALYTICAL BIOCHEMISTRY
LA English
DT Article
DE Sedimentation velocity; Analytical ultracentrifugation
ID PROTEIN-PROTEIN INTERACTIONS; ANALYTICAL ULTRACENTRIFUGATION; LAMM
   EQUATION; COEFFICIENT DISTRIBUTIONS; SYSTEMS; MACROMOLECULES;
   EQUILIBRIUM; CONSTANTS; BOUNDARY
AB The quality of fit of sedimentation velocity data is critical to judge the veracity of the sedimentation model and accuracy of the derived macromolecular parameters. Absolute statistical measures are usually complicated by the presence of characteristic systematic errors and run-to-run variation in the stochastic noise of data acquisition. We present a new graphical approach to visualize systematic deviations between data and model in the form of a histogram of residuals. In comparison with the ideally expected Gaussian distribution, it can provide a robust measure of fit quality and be used to flag poor models. Published by Elsevier Inc.
C1 [Ma, Jia; Zhao, Huaying; Schuck, Peter] Natl Inst Biomed Imaging & Bioengn, Dynam Macromol Assembly Sect, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD 20892 USA.
RP Schuck, P (reprint author), Natl Inst Biomed Imaging & Bioengn, Dynam Macromol Assembly Sect, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD 20892 USA.
EM schuckp@mail.nih.gov
OI Schuck, Peter/0000-0002-8859-6966
FU Intramural Research Program of the National Institute of Biomedical
   Imaging and Bioengineering, National Institutes of Health
FX We thank Dr. Rodolfo Ghirlando for critical reading of the manuscript.
   This work was supported by the Intramural Research Program of the
   National Institute of Biomedical Imaging and Bioengineering, National
   Institutes of Health.
NR 31
TC 4
Z9 4
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0003-2697
EI 1096-0309
J9 ANAL BIOCHEM
JI Anal. Biochem.
PD AUG 15
PY 2015
VL 483
BP 1
EP 3
DI 10.1016/j.ab.2015.04.029
PG 3
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA CK7FP
UT WOS:000356398500001
PM 25959995
ER

PT J
AU Campos, NG
   Maza, M
   Alfaro, K
   Gage, JC
   Castle, PE
   Felix, JC
   Cremer, ML
   Kim, JJ
AF Campos, Nicole G.
   Maza, Mauricio
   Alfaro, Karla
   Gage, Julia C.
   Castle, Philip E.
   Felix, Juan C.
   Cremer, Miriam L.
   Kim, Jane J.
TI The comparative and cost-effectiveness of HPV-based cervical cancer
   screening algorithms in El Salvador
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE cancer screening; human papillomavirus (HPV); HPV DNA tests; uterine
   cervical neoplasms; decision analysis; mathematical model; El Salvador
ID NATURAL-HISTORY MODEL; HUMAN-PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA;
   WOMEN; METAANALYSIS; VACCINATION; CRYOTHERAPY; PREVALENCE; COUNTRIES;
   ACCURACY
AB Cervical cancer is the leading cause of cancer death among women in El Salvador. Utilizing data from the Cervical Cancer Prevention in El Salvador (CAPE) demonstration project, we assessed the health and economic impact of HPV-based screening and two different algorithms for the management of women who test HPV-positive, relative to existing Pap-based screening. We calibrated a mathematical model of cervical cancer to epidemiologic data from El Salvador and compared three screening algorithms for women aged 30-65 years: (i) HPV screening every 5 years followed by referral to colposcopy for HPV-positive women (Colposcopy Management [CM]); (ii) HPV screening every 5 years followed by treatment with cryotherapy for eligible HPV-positive women (Screen and Treat [ST]); and (iii) Pap screening every 2 years followed by referral to colposcopy for Pap-positive women (Pap). Potential harms and complications associated with overtreatment were not assessed. Under base case assumptions of 65% screening coverage, HPV-based screening was more effective than Pap, reducing cancer risk by similar to 60% (Pap: 50%). ST was the least costly strategy, and cost $2,040 per year of life saved. ST remained the most attractive strategy as visit compliance, costs, coverage, and test performance were varied. We conclude that a screen-and-treat algorithm within an HPV-based screening program is very cost-effective in El Salvador, with a cost-effectiveness ratio below per capita GDP.
C1 [Campos, Nicole G.; Kim, Jane J.] Harvard Univ, TH Chan Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Hlth Decis Sci, Boston, MA 02115 USA.
   [Maza, Mauricio; Alfaro, Karla; Cremer, Miriam L.] Basic Hlth Int, San Salvador, El Salvador.
   [Gage, Julia C.] NCI, Dept Canc Epidemiol & Genet, Rockville, MD USA.
   [Castle, Philip E.] Global Coalit Cerv Canc, Arlington, VA USA.
   [Castle, Philip E.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Felix, Juan C.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA.
   [Cremer, Miriam L.] Cleveland Clin, Obstet Gynecol & Womens Hlth Inst, Cleveland, OH 44106 USA.
RP Campos, NG (reprint author), Ctr Hlth Decis Sci, 718 Huntington Ave, Boston, MA 02115 USA.
EM ncampos@hsph.harvard.edu
FU Basic Health International; Einhorn Family Charitable Trust
FX Grant sponsors: Basic Health International; Einhorn Family Charitable
   Trust
NR 28
TC 6
Z9 6
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD AUG 15
PY 2015
VL 137
IS 4
BP 893
EP 902
DI 10.1002/ijc.29438
PG 10
WC Oncology
SC Oncology
GA CK7QY
UT WOS:000356428400015
PM 25639903
ER

PT J
AU Pugacheva, EM
   Rivero-Hinojosa, S
   Espinoza, CA
   Mendez-Catala, CF
   Kang, S
   Suzuki, T
   Kosaka-Suzuki, N
   Robinson, S
   Nagarajan, V
   Ye, Z
   Boukaba, A
   Rasko, JEJ
   Strunnikov, AV
   Loukinov, D
   Ren, B
   Lobanenkov, VV
AF Pugacheva, Elena M.
   Rivero-Hinojosa, Samuel
   Espinoza, Celso A.
   Mendez-Catala, Claudia Fabiola
   Kang, Sungyun
   Suzuki, Teruhiko
   Kosaka-Suzuki, Natsuki
   Robinson, Susan
   Nagarajan, Vijayaraj
   Ye, Zhen
   Boukaba, Abdelhalim
   Rasko, John E. J.
   Strunnikov, Alexander V.
   Loukinov, Dmitri
   Ren, Bing
   Lobanenkov, Victor V.
TI Comparative analyses of CTCF and BORIS occupancies uncover two distinct
   classes of CTCF binding genomic regions
SO GENOME BIOLOGY
LA English
DT Article
ID MOUSE SPERM CHROMATIN; THYROID-HORMONE RECEPTOR; CANCER-TESTIS GENE;
   ZINC-FINGER FACTOR; REGULATORY SEQUENCES; ENHANCER BLOCKING;
   TRANSCRIPTION FACTORS; LINEAGE COMMITMENT; CELL IDENTITY; PROTEIN CTCF
AB Background: CTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation.
   Results: Here we show that these two proteins co-occupy a specific subset of regulatory elements consisting of clustered CTCF binding motifs (termed 2xCTSes). BORIS occupancy at 2xCTSes is largely invariant in BORIS-positive cancer cells, with the genomic pattern recapitulating the germline-specific BORIS binding to chromatin. In contrast to the single-motif CTCF target sites (1xCTSes), the 2xCTS elements are preferentially found at active promoters and enhancers, both in cancer and germ cells. 2xCTSes are also enriched in genomic regions that escape histone to protamine replacement in human and mouse sperm. Depletion of the BORIS gene leads to altered transcription of a large number of genes and the differentiation of K562 cells, while the ectopic expression of this CTCF paralog leads to specific changes in transcription in MCF7 cells.
   Conclusions: We discover two functionally and structurally different classes of CTCF binding regions, 2xCTSes and 1xCTSes, revealed by their predisposition to bind BORIS. We propose that 2xCTSes play key roles in the transcriptional program of cancer and germ cells.
C1 [Pugacheva, Elena M.; Rivero-Hinojosa, Samuel; Mendez-Catala, Claudia Fabiola; Kang, Sungyun; Suzuki, Teruhiko; Kosaka-Suzuki, Natsuki; Robinson, Susan; Loukinov, Dmitri; Lobanenkov, Victor V.] NIAID, Mol Pathol Sect, Immunogenet Lab, NIH, Rockville, MD 20852 USA.
   [Espinoza, Celso A.; Ye, Zhen; Ren, Bing] Ludwig Inst Canc Res, La Jolla, CA 92093 USA.
   [Espinoza, Celso A.; Ren, Bing] Univ Calif San Diego, San Diego Sch Med, Dept Cellular & Mol Med, Inst Genom Med,Moores Canc Ctr, La Jolla, CA 92093 USA.
   [Nagarajan, Vijayaraj] NIAID, Bioinformat & Computat Biosci Branch, Off Cyber Infrastruct & Computat Biol, NIH, Bethesda, MD 20892 USA.
   [Suzuki, Teruhiko] Tokyo Metropolitan Inst Med Sci, Stem Cell Project, Setagaya Ku, Tokyo 113, Japan.
   [Boukaba, Abdelhalim; Strunnikov, Alexander V.] Guangzhou Inst Biomed & Hlth, Mol Epigenet Lab, Guangzhou 510530, Guangdong, Peoples R China.
   [Rasko, John E. J.] Centenary Inst, Gene & Stem Cell Therapy Program, Camperdown, NSW 2050, Australia.
   [Rasko, John E. J.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Rasko, John E. J.] Royal Prince Alfred Hosp, Cell & Mol Therapies, Camperdown, NSW 2050, Australia.
RP Ren, B (reprint author), Ludwig Inst Canc Res, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM biren@ucsd.edu; vlobanenkov@mail.nih.gov
OI Lobanenkov, Victor/0000-0001-6665-3635; Strunnikov,
   Alexander/0000-0002-9058-2256
FU Intramural Research Program of the National Institute of Allergy and
   Infectious Diseases, National Institutes of Health; Ludwig Institute for
   Cancer Research; California Institute of Regenerative Medicine
   [RN2-00905]; US National Institutes of Health [P50 GM085764-03, U01
   ES017166]; NIH/NCI [T32 CA009523-27S1]; PRC; Cancer Council NSW
   [RG11-12, RG14-05, RG14-09]; Tour de Cure; Cure the Future (Cell and
   Gene Trust)
FX This work was supported by the Intramural Research Program of the
   National Institute of Allergy and Infectious Diseases, National
   Institutes of Health. Work in the BR lab was supported by funds from the
   Ludwig Institute for Cancer Research, the California Institute of
   Regenerative Medicine (RN2-00905) and US National Institutes of Health
   (P50 GM085764-03 and U01 ES017166). The work of CAE was supported by
   training grant NIH/NCI T32 CA009523-27S1. The work of AVS was supported
   by the 1000 Talents Award from the PRC. JEJR acknowledges generous
   funding from the Cancer Council NSW (RG11-12; RG14-05; RG14-09), Tour de
   Cure and Cure the Future (Cell and Gene Trust). This study used the
   Office of Cyber Infrastructure and Computational Biology (OCICB) High
   Performance Computing (HPC) cluster at the National Institute of Allergy
   and Infectious Diseases (NIAID), Bethesda, MD. This work utilized the
   high-performance computational capabilities of the Biowulf Linux cluster
   at the National Institutes of Health, Bethesda, MD.
NR 82
TC 10
Z9 11
U1 6
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1474-760X
J9 GENOME BIOL
JI Genome Biol.
PD AUG 14
PY 2015
VL 16
DI 10.1186/s13059-015-0736-8
PG 24
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CQ5YW
UT WOS:000360682600001
PM 26268681
ER

PT J
AU Sato, K
   Nagaya, T
   Nakamura, Y
   Harada, T
   Choyke, PL
   Kobayashi, H
AF Sato, Kazuhide
   Nagaya, Tadanobu
   Nakamura, Yuko
   Harada, Toshiko
   Choyke, Peter L.
   Kobayashi, Hisataka
TI Near infrared photoimmunotherapy prevents lung cancer metastases in a
   murine model
SO ONCOTARGET
LA English
DT Article
DE near infrared photoimmunotherapy; metastasis prevention; targeted
   metastasis treatment; HER2 receptor
ID IN-VIVO; DISSEMINATION; THERAPEUTICS; GROWTH; CELLS
AB Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies with the acute toxicity induced by photosensitizers after exposure to NIR-light. Herein, we evaluate the efficacy of NIR-PIT in preventing lung metastases in a mouse model. Lung is one of the most common sites for developing metastases, but it also has the deepest tissue light penetration. Thus, lung is the ideal site for treating early metastases by using a light-based strategy. In vitro NIR-PIT cytotoxicity was assessed with dead cell staining, luciferase activity, and a decrease in cytoplasmic GFP fluorescence in 3T3/HER2-luc-GFP cells incubated with an anti-HER2 antibody photosensitizer conjugate. Cell-specific killing was demonstrated in mixed 2D/3D cell cultures of 3T3/HER2-lucGFP (target) and 3T3-RFP (non-target) cells. In vivo NIR-PIT was performed in the left lung in a mouse model of lung metastases, and the number of metastasis nodules, tumor fluorescence, and luciferase activity were all evaluated. All three evaluations demonstrated that the NIR-PIT-treated lung had significant reductions in metastatic disease (*p < 0.0001, Mann-Whitney U-test) and that NIR-PIT did not damage nontarget tumors or normal lung tissue. Thus, NIR-PIT can specifically prevent early metastases and is a promising anti-metastatic therapy.
C1 [Sato, Kazuhide; Nagaya, Tadanobu; Nakamura, Yuko; Harada, Toshiko; Choyke, Peter L.; Kobayashi, Hisataka] NCI, Ctr Canc Res, Mol Imaging Program, Bethesda, MD 20892 USA.
RP Kobayashi, H (reprint author), NCI, Ctr Canc Res, Mol Imaging Program, Bethesda, MD 20892 USA.
EM Kobayash@mail.nih.gov
FU Intramural Research Program of National Institutes of Health; National
   Cancer Institute, Center for Cancer Research; JSPS Research Fellowship
   for Japanese Biomedical and Behavioral Researchers at NIH
FX This research was supported by the Intramural Research Program of the
   National Institutes of Health, National Cancer Institute, Center for
   Cancer Research. K.S. is supported with JSPS Research Fellowship for
   Japanese Biomedical and Behavioral Researchers at NIH.
NR 28
TC 7
Z9 7
U1 0
U2 0
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD AUG 14
PY 2015
VL 6
IS 23
BP 19747
EP 19758
PG 12
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA CP8HY
UT WOS:000360135300043
PM 25992770
ER

PT J
AU Dou, WF
   Xu, YM
   Pagadala, V
   Pedersen, LC
   Liu, J
AF Dou, Wenfang
   Xu, Yongmei
   Pagadala, Vijayakanth
   Pedersen, Lars C.
   Liu, Jian
TI Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in
   Forming N-Sulfated Domain in Heparan Sulfate
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID MOLECULAR-WEIGHT HEPARINS; SUBSTRATE-SPECIFICITY; CHEMOENZYMATIC
   SYNTHESIS; BIOSYNTHESIS; NDST-1; CELLS; MOUSE; MICE;
   2-O-SULFOTRANSFERASE; GLYCOSAMINOGLYCANS
AB Heparan sulfate (HS) is a highly sulfated polysaccharide that plays important physiological roles. The biosynthesis of HS involves a series of enzymes, including glycosyltransferases (or HS polymerase), epimerase, and sulfotransferases. N-Deacetylase/N-Sulfotransferase isoform 1 (NDST-1) is a critical enzyme in this pathway. NDST-1, a bifunctional enzyme, displays N-deacetylase and N-sulfotransferase activities to convert an N-acetylated glucosamine residue to an N-sulfo glucosamine residue. Here, we report the cooperative effects between N-deacetylase and N-sulfotransferase activities. Using baculovirus expression in insect cells, we obtained three recombinant proteins: full-length NDST-1 and the individual N-deacetylase and N-sulfotransferase domains. Structurally defined oligosaccharide substrates were synthesized to test the substrate specificities of the enzymes. We discovered that N-deacetylation is the limiting step and that interplay between the N-sulfotransferase and N-deacetylase accelerates the reaction. Furthermore, combining the individually expressed N-deacetylase and N-sulfotransferase domains produced different sulfation patterns when compared with that made by the NDST-1 enzyme. Our data demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures.
C1 [Dou, Wenfang; Xu, Yongmei; Pagadala, Vijayakanth; Liu, Jian] Univ N Carolina, Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA.
   [Dou, Wenfang] Jiangnan Univ, Sch Pharmaceut Sci, Lab Pharmaceut Engn, Wuxi 214122, Peoples R China.
   [Pedersen, Lars C.] NIEHS, Genome Integr & Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Liu, J (reprint author), Univ N Carolina, Rm 1044,Genet Med Bldg,120 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM jian_liu@unc.edu
RI Regan, Clinton/E-6250-2012
FU National Institutes of Health [GM102137, HL094463]; Division of
   Intramural Research of the NIEHS, National Institutes of Health Research
   [ZIA ES102645]; China Scholarship Council
FX This work was supported in part by National Institutes of Health Grants
   GM102137 and HL094463 and by the Division of Intramural Research of the
   NIEHS, National Institutes of Health Research Project number ZIA
   ES102645 (to L. C. P.). The authors declare that they have no conflicts
   of interest with the contents of this article.; Partially supported by a
   fellowship from the China Scholarship Council.
NR 46
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U1 3
U2 12
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 14
PY 2015
VL 290
IS 33
BP 20427
EP 20437
DI 10.1074/jbc.M115.664409
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CP1AT
UT WOS:000359608900040
PM 26109066
ER

PT J
AU Cokic, VP
   Mossuz, P
   Han, J
   Socoro, N
   Beleslin-Cokic, BB
   Mitrovic, O
   Suboticki, T
   Diklic, M
   Lekovic, D
   Gotic, M
   Puri, RK
   Noguchi, CT
   Schechter, AN
AF Cokic, Vladan P.
   Mossuz, Pascal
   Han, Jing
   Socoro, Nuria
   Beleslin-Cokic, Bojana B.
   Mitrovic, Olivera
   Suboticki, Tijana
   Diklic, Milos
   Lekovic, Danijela
   Gotic, Mirjana
   Puri, Raj K.
   Noguchi, Constance Tom
   Schechter, Alan N.
TI Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a
   Highlight on the mTOR Signaling Pathway
SO PLOS ONE
LA English
DT Article
ID GENE-EXPRESSION; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; MAMMALIAN
   TARGET; BREAST-CANCER; MEGAKARYOCYTE PROGENITORS; HEMATOPOIETIC STEM;
   RHEB GTPASE; CELLS; PROLIFERATION
AB The gene and protein expression profiles in myeloproliferative neoplasms (MPNs) may reveal gene and protein markers of a potential clinical relevance in diagnosis, treatment and prediction of response to therapy. Using cDNA microarray analysis of 25,100 unique genes, we studied the gene expression profile of CD34(+) cells and granulocytes obtained from peripheral blood of subjects with essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). The microarray analyses of the CD34(+) cells and granulocytes were performed from 20 de novo MPN subjects: JAK2 positive ET, PV, PMF subjects, and JAK2 negative ET/PMF subjects. The granulocytes for proteomic studies were pooled in 4 groups: PV with JAK2 mutant allele burden above 80%, ET with JAK2 mutation, PMF with JAK2 mutation and ET/PMF with no JAK2 mutation. The number of differentially regulated genes was about two fold larger in CD34(+) cells compared to granulocytes. Thirty-six genes (including RUNX1, TNFRSF19) were persistently highly expressed, while 42 genes (including FOXD4, PDE4A) were underexpressed both in CD34(+) cells and granulocytes. Using proteomic studies, significant up-regulation was observed for MAPK and PI3K/AKT signaling regulators that control myeloid cell apoptosis and proliferation: RAC2, MNDA, S100A8/9, CORO1A, and GNAI2. When the status of the mTOR signaling pathway related genes was analyzed, PI3K/AKT regulators were preferentially up-regulated in CD34(+) cells of MPNs, with down-regulated major components of the protein complex EIF4F. Molecular profiling of CD34(+) cells and granulocytes of MPN determined gene expression patterns beyond their recognized function in disease pathogenesis that included dominant up-regulation of PI3K/AKT signaling.
C1 [Cokic, Vladan P.; Mitrovic, Olivera; Suboticki, Tijana; Diklic, Milos] Univ Belgrade, Inst Med Res, Belgrade, Serbia.
   [Mossuz, Pascal] CHU Grenoble, Inst Biol & Pathol, Dept Hematol, F-38043 Grenoble, France.
   [Han, Jing; Puri, Raj K.] US FDA, Tumor Vaccines & Biotechnol Branch, Div Cellular & Gene Therapies, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA.
   [Socoro, Nuria] Fac Med Grenoble, Lab TIMC IMAG, Grenoble, France.
   [Beleslin-Cokic, Bojana B.] Clin Ctr Serbia, Clin Endocrinol Diabet & Dis Metab, Belgrade, Serbia.
   [Lekovic, Danijela; Gotic, Mirjana] Clin Ctr Serbia, Clin Hematol, Belgrade, Serbia.
   [Gotic, Mirjana] Univ Belgrade, Fac Med, Belgrade, Serbia.
   [Noguchi, Constance Tom; Schechter, Alan N.] Natl Inst Diabet & Digest & Kidney Dis, Mol Med Branch, NIH, Bethesda, MD USA.
RP Cokic, VP (reprint author), Univ Belgrade, Inst Med Res, Belgrade, Serbia.
EM vl@imi.bg.ac.rs
FU Intramural Research Program of the National Institute of Diabetes and
   Digestive and Kidney Diseases; National Institutes of Health; Serbian
   Ministry of Education, Science and Technological Development [175053]
FX This work was supported by the Intramural Research Program of the
   National Institute of Diabetes and Digestive and Kidney Diseases and the
   National Institutes of Health and by a grant from the Serbian Ministry
   of Education, Science and Technological Development [175053].
NR 41
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U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2015
VL 10
IS 8
AR e0135463
DI 10.1371/journal.pone.0135463
PG 23
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9KD
UT WOS:000359493600068
PM 26275051
ER

PT J
AU Marzi, A
   Robertson, SJ
   Haddock, E
   Feldmann, F
   Hanley, PW
   Scott, DP
   Strong, JE
   Kobinger, G
   Best, SM
   Feldmann, H
AF Marzi, Andrea
   Robertson, Shelly J.
   Haddock, Elaine
   Feldmann, Friederike
   Hanley, Patrick W.
   Scott, Dana P.
   Strong, James E.
   Kobinger, Gary
   Best, Sonja M.
   Feldmann, Heinz
TI VSV-EBOV rapidly protects macaques against infection with the 2014/15
   Ebola virus outbreak strain
SO SCIENCE
LA English
DT Article
ID NONHUMAN-PRIMATES; VACCINE; CHALLENGE; VECTORS
AB The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated vector with marked preclinical efficacy. Here, we provide the preclinical proof that VSV-EBOV completely protects macaques against lethal challenge with the West African EBOV-Makona strain. Complete and partial protection was achieved with a single dose given as late as 7 and 3 days before challenge, respectively. This indicates that VSV-EBOV may protect humans against EBOV infections in West Africa with relatively short time to immunity, promoting its use for immediate public health responses.
C1 [Marzi, Andrea; Robertson, Shelly J.; Haddock, Elaine; Best, Sonja M.; Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA.
   [Feldmann, Friederike; Hanley, Patrick W.; Scott, Dana P.] NIAID, Rocky Mt Vet Branch, Div Intramural Res, NIH, Hamilton, MT 59840 USA.
   [Strong, James E.; Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada.
RP Feldmann, H (reprint author), NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA.
EM feldmannh@niaid.nih.gov
FU Rocky Mountain Veterinary Branch [NIH, National Institute of Allergy and
   Infectious Diseases (NIAID)]; Division of Intramural Research, NIAID,
   NIH; Public Health Agency of Canada; Center for Security Science
   Program, Canada
FX We thank the Rocky Mountain Veterinary Branch [NIH, National Institute
   of Allergy and Infectious Diseases (NIAID)] for its support of this
   study. This work was jointly funded by the Division of Intramural
   Research, NIAID, NIH; the Public Health Agency of Canada; and the Center
   for Security Science Program, Canada. Use of the GMP-produced vaccine
   material is regulated through the Public Health Agency of Canada. The
   authors declare no competing financial interests. H.F. is a co-applicant
   on two patents regarding VSV-EBOV (U.S. patent application nos.
   PCT/CA03/01125US and 61/014,626). The data are available via figshare:
   http://dx.doi.org/10.6084/m9.figshare.1456239.
NR 24
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U1 3
U2 35
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD AUG 14
PY 2015
VL 349
IS 6249
BP 739
EP 742
DI 10.1126/science.aab3920
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO8JO
UT WOS:000359415100037
PM 26249231
ER

PT J
AU Williams, WB
   Liao, HX
   Moody, MA
   Kepler, TB
   Alam, SM
   Gao, F
   Wiehe, K
   Trama, AM
   Jones, K
   Zhang, RJ
   Song, HS
   Marshall, DJ
   Whitesides, JF
   Sawatzki, K
   Hua, AX
   Liu, PH
   Tay, MZ
   Seaton, KE
   Shen, XY
   Foulger, A
   Lloyd, KE
   Parks, R
   Pollara, J
   Ferrari, G
   Yu, JS
   Vandergrift, N
   Montefiori, DC
   Sobieszczyk, ME
   Hammer, S
   Karuna, S
   Gilbert, P
   Grove, D
   Grunenberg, N
   McElrath, MJ
   Mascola, JR
   Koup, RA
   Corey, L
   Nabel, GJ
   Morgan, C
   Churchyard, G
   Maenza, J
   Keefer, M
   Graham, BS
   Baden, LR
   Tomaras, GD
   Haynes, BF
AF Williams, Wilton B.
   Liao, Hua-Xin
   Moody, M. Anthony
   Kepler, Thomas B.
   Alam, S. Munir
   Gao, Feng
   Wiehe, Kevin
   Trama, Ashley M.
   Jones, Kathryn
   Zhang, Ruijun
   Song, Hongshuo
   Marshall, Dawn J.
   Whitesides, John F.
   Sawatzki, Kaitlin
   Hua, Axin
   Liu, Pinghuang
   Tay, Matthew Z.
   Seaton, Kelly E.
   Shen, Xiaoying
   Foulger, Andrew
   Lloyd, Krissey E.
   Parks, Robert
   Pollara, Justin
   Ferrari, Guido
   Yu, Jae-Sung
   Vandergrift, Nathan
   Montefiori, David C.
   Sobieszczyk, Magdalena E.
   Hammer, Scott
   Karuna, Shelly
   Gilbert, Peter
   Grove, Doug
   Grunenberg, Nicole
   McElrath, M. Juliana
   Mascola, John R.
   Koup, Richard A.
   Corey, Lawrence
   Nabel, Gary J.
   Morgan, Cecilia
   Churchyard, Gavin
   Maenza, Janine
   Keefer, Michael
   Graham, Barney S.
   Baden, Lindsey R.
   Tomaras, Georgia D.
   Haynes, Barton F.
TI Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota
   cross-reactive antibodies
SO SCIENCE
LA English
DT Article
ID BROADLY NEUTRALIZING ANTIBODIES; DNA CANDIDATE VACCINE; AFFINITY
   B-CELLS; NONNEUTRALIZING ANTIBODIES; IMMUNOGENICITY EVALUATION; ENVELOPE
   GLYCOPROTEIN; GP41-GP120 INTERFACE; DEPENDENT EPITOPE; GERMINAL-CENTERS;
   PHASE-1 SAFETY
AB An HIV-1 DNA prime vaccine, with a recombinant adenovirus type 5 (rAd5) boost, failed to protect from HIV-1 acquisition. We studied the nature of the vaccine-induced antibody (Ab) response to HIV-1 envelope (Env). HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41. Vaccine-induced gp41-reactive monoclonal antibodies were non-neutralizing and frequently polyreactive with host and environmental antigens, including intestinal microbiota (IM). Next-generation sequencing of an immunoglobulin heavy chain variable region repertoire before vaccination revealed an Env-IM cross-reactive Ab that was clonally related to a subsequent vaccine-induced gp41-reactive Ab. Thus, HIV-1 Env DNA-rAd5 vaccine induced a dominant IM-polyreactive, non-neutralizing gp41-reactive Ab repertoire response that was associated with no vaccine efficacy.
C1 [Williams, Wilton B.; Liao, Hua-Xin; Moody, M. Anthony; Alam, S. Munir; Gao, Feng; Wiehe, Kevin; Trama, Ashley M.; Jones, Kathryn; Zhang, Ruijun; Song, Hongshuo; Marshall, Dawn J.; Whitesides, John F.; Liu, Pinghuang; Tay, Matthew Z.; Seaton, Kelly E.; Shen, Xiaoying; Foulger, Andrew; Lloyd, Krissey E.; Parks, Robert; Pollara, Justin; Ferrari, Guido; Yu, Jae-Sung; Vandergrift, Nathan; Montefiori, David C.; Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA.
   [Kepler, Thomas B.; Sawatzki, Kaitlin; Hua, Axin] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
   [Sobieszczyk, Magdalena E.; Hammer, Scott] Columbia Univ, Med Ctr, Dept Med, New York, NY USA.
   [Karuna, Shelly; Grunenberg, Nicole; McElrath, M. Juliana; Corey, Lawrence; Maenza, Janine] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Gilbert, Peter; Grove, Doug; Morgan, Cecilia] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA.
   [Mascola, John R.; Koup, Richard A.; Nabel, Gary J.; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Churchyard, Gavin] Aurum Inst, Johannesburg, South Africa.
   [Keefer, Michael] Univ Rochester, Sch Med, Rochester, NY USA.
   [Baden, Lindsey R.] Brigham & Womens Hosp, Boston, MA 02115 USA.
RP Williams, WB (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA.
EM wilton.williams@duke.edu; barton.haynes@duke.edu
RI Tomaras, Georgia/J-5041-2016
FU NIH, NIAID UM-1 grant Center for HIV/AIDS Vaccine Immunology-Immunogen
   Discovery (CHAVI-ID) [UM1 AI100645]; NIH NIAID Duke University Center
   for AIDS Research (CFAR) [P30-AI-64518]; NIH NIAID HVTN Laboratory
   Center [UM1AI068618]; Vaccine Research Center, National Institute of
   Allergy and Infectious Diseases, NIH
FX The authors thank G. Kelsoe for manuscript review, L. Armand for
   production of fluorophore-labeled reagents, and C. Stolarchuk, S.
   Stewart, A. Wang, R. Duffy, A. Deal, J. Eudailey, T. Von Holle, J. Alin,
   L. Oliver, F. Jaeger, and S. Arora for technical assistance. The data
   presented in this manuscript are tabulated in the main paper and in the
   supplementary materials. Research materials used in this study are
   available from Duke University upon request and subsequent execution of
   an appropriate materials transfer agreement. Supported by NIH, NIAID
   UM-1 grant Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery
   (CHAVI-ID; UM1 AI100645), NIH NIAID Duke University Center for AIDS
   Research (CFAR; P30-AI-64518), the NIH NIAID HVTN Laboratory Center
   UM1AI068618, and the intramural research program of the Vaccine Research
   Center, National Institute of Allergy and Infectious Diseases, NIH.
   W.B.W. designed and performed experiments, analyzed data, and co-wrote
   the paper; H.-X. L., K.J., M.A.M., D.J.M., and J.F.W. performed
   isolation of Abs, reviewed data, and edited the paper; T.B.K., A.H.,
   K.W., K.S., and A.M.T. performed computational analysis of Ab sequences;
   F. G., R.Z., and H.S. sequenced Abs and performed NGS; S.M.A., P.L.,
   M.Z.T., K.E.S., X.S., A. F., K.E.L., R.P., and J.-S.Y. performed Ab
   binding and functional assays; J.P. and G. F. performed ADCC assays;
   N.V., D.G., and P.G. performed statistical analysis; D.C.M. performed
   neutralization assays; M.E.S., S.H., S.K., N.G., M.J.M., J.R.M., R.A.K.,
   L.C, G.J.N., C.M., G.C., J.M., M.K., B.S.G., and L.R.B. were members of
   the VRC or HVTN teams that carried out the clinical trials; G.D.T.
   analyzed data, designed experiments, reviewed data, and edited the
   paper; and B.F.H. conceived and designed the study, performed ANA
   analysis, reviewed all data, and cowrote the paper. GenBank accession
   numbers for sequences of the 221 Abs isolated via flow cytometry memory
   B cell single-cell sorting: immunoglobulin heavy chains,
   KT304331-KT304551; immunoglobulin light chains, KT304552-KT304772.
NR 72
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U1 3
U2 16
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD AUG 14
PY 2015
VL 349
IS 6249
AR aab1253
DI 10.1126/science.aab1253
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO8JO
UT WOS:000359415100028
PM 26229114
ER

PT J
AU Takeda, K
   Adhikari, R
   Yamada, KM
   Dhawan, S
AF Takeda, Kazuyo
   Adhikari, Rewati
   Yamada, Kenneth M.
   Dhawan, Subhash
TI Hemin activation of innate cellular response blocks human
   immunodeficiency virus type-1-induced osteoclastogenesis
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE HIV-1; Hemin; Heme oxygenase-1; Osteoclasts
ID BONE-MINERAL DENSITY; MULTINUCLEATED GIANT-CELLS; HIV-INFECTION;
   OXYGENASE-1 INDUCTION; PROTEASE INHIBITORS; RISK-FACTORS; DISEASE;
   OSTEOPOROSIS; RANKL; PATHOGENESIS
AB The normal skeletal developmental and homeostatic process termed osteoclastogenesis is exacerbated in numerous pathological conditions and causes excess bone loss. In cancer and HIV-1-infected patients, this disruption of homeostasis results in osteopenia and eventual osteoporesis. Counteracting the factors responsible for these metabolic disorders remains a challenge for preventing or minimizing this comorbidity associated with these diseases. In this report, we demonstrate that a hemin-induced host protection mechanism not only suppresses HIV-1 associated osteoclastogenesis, but it also exhibits anti-osteoclastogenic activity for non-infected cells. Since the mode of action of hemin is both physiological and pharmacological through induction of heme oxygenase-1 (HO-1), an endogenous host protective response to an FDA-licensed therapeutic used to treat another disease, our study suggests an approach to developing novel, safe and effective therapeutic strategies for treating bone disorders, because hemin administration in humans has previously met required FDA safety standards. Published by Elsevier Inc.
C1 [Adhikari, Rewati; Dhawan, Subhash] US FDA, Ctr Biol Evaluat & Res, Div Transfus Transmitted Dis, Bethesda, MD 20993 USA.
   [Takeda, Kazuyo] US FDA, Ctr Biol Evaluat & Res, Microscopy & Imaging Core Facil, Silver Spring, MD USA.
   [Yamada, Kenneth M.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA.
RP Dhawan, S (reprint author), US FDA, Ctr Biol Evaluat & Res, Div Transfus Transmitted Dis, Bethesda, MD 20993 USA.
EM subhash.dhawan@fda.hhs.gov
FU FDA; NIDCR Intramural Research Programs
FX S.D.: conceptualized, designed, performed, analyzed experiments, and
   wrote the paper; K.T. performed confocal microscopy and analyzed
   experiments; R.A. performed TRAP activity experiments; K.M.Y. analyzed
   experiments. We thank Dr. Zu-Xi Yu, National Heart, Lung and Blood
   Institute, NIH, for his expertise in microscopy. The findings and
   conclusions in this paper have not been formally disseminated by the
   Food and Drug Administration and should not be construed to represent
   any Agency determination or policy. This work was supported by FDA and
   NIDCR Intramural Research Programs.
NR 49
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U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 14
PY 2015
VL 464
IS 1
BP 7
EP 12
DI 10.1016/j.bbrc.2015.05.037
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CO5AY
UT WOS:000359173200002
PM 25998388
ER

PT J
AU Liese, AD
   Crandell, JL
   Tooze, JA
   Kipnis, V
   Bell, R
   Couch, SC
   Dabelea, D
   Crume, TL
   Mayer-Davis, EJ
AF Liese, Angela D.
   Crandell, Jamie L.
   Tooze, Janet A.
   Kipnis, Victor
   Bell, Ronny
   Couch, Sarah C.
   Dabelea, Dana
   Crume, Tessa L.
   Mayer-Davis, Elizabeth J.
TI Sugar-sweetened beverage intake and cardiovascular risk factor profile
   in youth with type 1 diabetes: application of measurement error
   methodology in the SEARCH Nutrition Ancillary Study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE FFQ validation; Reliability; Youth; Diabetes mellitus
ID EPISODICALLY CONSUMED FOODS; DIETARY MEASUREMENT ERROR; GLUCOSE CONTROL;
   BLOOD-PRESSURE; UNITED-STATES; SERUM-LIPIDS; CHILDHOOD; ADULTS;
   CONSUMPTION; ADOLESCENTS
AB The SEARCH Nutrition Ancillary Study aims to investigate the role of dietary intake on the development of long-term complications of type 1 diabetes in youth, and capitalise on measurement error (ME) adjustment methodology. Using the National Cancer Institute (NCI) method for episodically consumed foods, we evaluated the relationship between sugar-sweetened beverage (SSB) intake and cardiovascular risk factor profile, with the application of ME adjustment methodology. The calibration sample included 166 youth with two FFQ and three 24 h dietary recall data within 1 month. The full sample included 2286 youth with type 1 diabetes. SSB intake was significantly associated with higher TAG, total and LDL-cholesterol concentrations, after adjusting for energy, age, diabetes duration, race/ethnicity, sex and education. The estimated effect size was larger (model coefficients increased approximately 3-fold) after the application of the NCI method than without adjustment for ME. Compared with individuals consuming one serving of SSB every 2 weeks, those who consumed one serving of SSB every 2 d had 3.7 mg/dl (0.04 mmol/l) higher TAG concentrations and 4.0 mg/dl (0.10 mmol/l) higher total cholesterol and LDL-cholesterol concentrations, after adjusting for ME and covariates. SSB intake was not associated with measures of adiposity and blood pressure. Our findings suggest that SSB intake is significantly related to increased lipid levels in youth with type 1 diabetes, and that estimates of the effect size of SSB on lipid levels are severely attenuated in the presence of ME. Future studies in youth with diabetes should consider a design that will allow for the adjustment for ME when studying the influence of diet on health status.
C1 [Liese, Angela D.] Univ S Carolina, Arnold Sch Publ Hlth, Ctr Res Nutr & Hlth Dispar, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Crandell, Jamie L.] Univ N Carolina, Sch Nursing & Dept Biostat, Chapel Hill, NC USA.
   [Tooze, Janet A.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA.
   [Kipnis, Victor] NCI, Biometry, Canc Prevent Div, Rockville, MD USA.
   [Bell, Ronny] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
   [Couch, Sarah C.] Univ Cincinnati, Med Ctr, Dept Nutr Sci, Cincinnati, OH 45267 USA.
   [Dabelea, Dana; Crume, Tessa L.] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO 80202 USA.
   [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA.
   [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
RP Liese, AD (reprint author), Univ S Carolina, Arnold Sch Publ Hlth, Ctr Res Nutr & Hlth Dispar, Dept Epidemiol & Biostat, 915 Greene St, Columbia, SC 29208 USA.
EM liese@sc.edu
FU Centers for Disease Control and Prevention [00097, DP-05-069,
   DP-10-001]; National Institute of Diabetes and Digestive and Kidney
   Diseases; NIH/NCRR [UL1RR029882]; NIH CTSA Grant of University of
   Washington [UL1 TR00423]; DERC NIH [P30 DK57516];  [5R01DK077949];  [UL1
   TR000154];  [8 UL1 TR000077]
FX The SNAS was funded by 5R01DK077949 (Mayer-Davis, principal
   investigator). The authors also acknowledge the staff at the UNC
   Nutrition Obesity Research Center - Diet, Physical Activity and Body
   Composition Core (DK-56350) who conducted the 24h dietary recall
   interviews. The SEARCH for Diabetes in Youth Study is indebted to the
   many youth and their families, and their health care providers, whose
   participation made this study possible.; The SEARCH for Diabetes in
   Youth Study was funded by the Centers for Disease Control and Prevention
   (PA no. 00097, DP-05-069 and DP-10-001) and supported by the National
   Institute of Diabetes and Digestive and Kidney Diseases.; Site contract
   numbers are as follows: Kaiser Permanente Southern California
   (U48/CCU919219, U01 DP000246 and U18DP002714); University of Colorado
   Denver (U48/CCU819241-3, U01 DP000247 and U18DP000247-06A1); Kuakini
   Medical Center (U58CCU919256 and U01 DP000245); Children's Hospital
   Medical Center (Cincinnati) (U48/CCU519239, U01 DP000248 and
   1U18DP002709); University of North Carolina at Chapel Hill
   (U48/CCU419249, U01 DP000254 and U18DP002708); University of Washington
   School of Medicine (U58/CCU019235-4, U01 DP000244 and U18DP002710-01);
   Wake Forest University School of Medicine (U48/CCU919219, U01 DP000250
   and 200-2010-35171).; The authors acknowledge the involvement of General
   Clinical Research Centers at the South Carolina Clinical and
   Translational Research Institute, at the Medical University of South
   Carolina (NIH/NCRR grant no. UL1RR029882); Seattle Children's Hospital
   (NIH CTSA Grant UL1 TR00423 of the University of Washington); University
   of Colorado Pediatric Clinical and Translational Research Center (grant
   no. UL1 TR000154); the Barbara Davis Center at the University of
   Colorado at Denver (DERC NIH P30 DK57516); the National Center for
   Research Resources and the National Center for Advancing Translational
   Sciences, National Institutes of Health (through Grant 8 UL1 TR000077);
   and the Children with Medical Handicaps Program managed by the Ohio
   Department of Health.
NR 31
TC 1
Z9 1
U1 2
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 14
PY 2015
VL 114
IS 3
BP 430
EP 438
DI 10.1017/S0007114515002160
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CO6JM
UT WOS:000359263000010
PM 26177613
ER

PT J
AU Zhao, XL
   Chen, WJ
   Zhou, ZY
   Wang, QQ
   Liu, ZH
   Moaddel, R
   Jiang, ZJ
AF Zhao, XiangLong
   Chen, WeiJia
   Zhou, ZhengYin
   Wang, QiQin
   Liu, ZhengHua
   Moaddel, Ruin
   Jiang, ZhengJin
TI Preparation of a biomimetic polyphosphorylcholine monolithic column for
   immobilized artificial membrane chromatography
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Immobilized artificial membrane; Monolithic columns; Phosphatidylcholine
ID HYDROPHILIC INTERACTION CHROMATOGRAPHY; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; DRUG ABSORPTION; PURIFICATION;
   SURFACES; SEPARATION; SILICA; HPLC; PHOSPHATIDYLCHOLINE
AB The present work aims to prepare a novel phosphatidylcholine functionalized monolithic stationary phase by in situ co-polymerization of 12-methacryloyl dodecylphosphocholine (MDPC) and ethylene dimethacrylate (EDMA) for immobilized artificial membrane chromatography. Scanning electron microscopy, energy dispersive X-ray spectroscopy, FT-IR spectroscopy, pore size distribution analysis, zeta-potential analysis and micro-HPLC were used to evaluate the monolithic structure and physicochemical properties. Satisfactory morphology, high mechanical stability, good permeability and chromatographic performance were obtained on the optimized monolithic columns. A typical reverse-phase retention mechanism was observed over a wide range of organic solvent content (acetonitrile< 80%). The optimized poly(MDPC-co-EDMA) monolith exhibited good selectivity for proteins and basic drugs. Good correlation was observed between the retention on commercial IAM column (IAM.PC.DD2) and poly(MDPC-co-EDMA) monolith. This novel poly(MDPC-co-EDMA) monolith exhibited good potential for studying the drug-membrane interaction. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Zhao, XiangLong; Chen, WeiJia; Zhou, ZhengYin; Wang, QiQin; Liu, ZhengHua; Moaddel, Ruin; Jiang, ZhengJin] Jinan Univ, Dept Pharm, Guangzhou 510632, Guangdong, Peoples R China.
   [Zhao, XiangLong; Chen, WeiJia; Zhou, ZhengYin; Wang, QiQin; Liu, ZhengHua; Moaddel, Ruin; Jiang, ZhengJin] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China.
   [Moaddel, Ruin] NIA, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.
RP Jiang, ZJ (reprint author), Jinan Univ, Dept Pharm, Guangzhou 510632, Guangdong, Peoples R China.
EM jzjjackson@hotmail.com
FU National Natural Science Foundation of China [81273477]; 111 Project
   [B13038]; Jinan University; Intramural Research Program of the National
   Institute on Aging/NIH
FX We gratefully appreciate the financial support by the program from the
   National Natural Science Foundation of China (Grant: 81273477) and the
   111 Project (No. B13038). Qiqin Wang gratefully acknowledges funding
   from "Excellent doctoral climb program" within the Jinan University.
   This work was supported in part by funding from the Intramural Research
   Program of the National Institute on Aging/NIH(RM).
NR 39
TC 4
Z9 4
U1 3
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD AUG 14
PY 2015
VL 1407
BP 176
EP 183
DI 10.1016/j.chroma.2015.06.056
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA CN9YU
UT WOS:000358807900018
PM 26152527
ER

PT J
AU Fatima, N
   Cohen, DC
   Sukumar, G
   Sissung, TM
   Schooley, JF
   Haigney, MC
   Claycomb, WC
   Cox, RT
   Dalgard, CL
   Bates, SE
   Flagg, TP
AF Fatima, Naheed
   Cohen, Devin C.
   Sukumar, Gauthaman
   Sissung, Tristan M.
   Schooley, James F., Jr.
   Haigney, Mark C.
   Claycomb, William C.
   Cox, Rachel T.
   Dalgard, Clifton L.
   Bates, Susan E.
   Flagg, Thomas P.
TI Histone deacetylase inhibitors modulate K-ATP subunit transcription in
   HL-1 cardiomyocytes through effects on cholesterol homeostasis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE epigenetics; Abcc8; Abcc9; romidepsin; cholesterol; SREBP
ID SENSITIVE POTASSIUM CHANNEL; ST-SEGMENT ELEVATION; T-CELL LYMPHOMA;
   CARDIAC-HYPERTROPHY; SULFONYLUREA RECEPTOR; PHASE-II;
   ISCHEMIA/REPERFUSION INJURY; HDAC INHIBITORS; DEPSIPEPTIDE; HEART
AB Histone deacetylase inhibitors (HDIs) are under investigation for the treatment of a number of human health problems. HDIs have proven therapeutic value in refractory cases of cutaneous T-cell lymphoma. Electrocardiographic ST segment morphological changes associated with HDIs were observed during development. Because ST segment morphology is typically linked to changes in ATP sensitive potassium (K-ATP) channel activity, we tested the hypothesis that HDIs affect cardiac K-ATP channel subunit expression. Two different HDIs, romidepsin and trichostatin A, caused similar to 20-fold increase in SUR2 (Abcc9) subunit mRNA expression in HL-1 cardiomyocytes. The effect was specific for the SUR2 subunit as neither compound causes a marked change in SUR1 (Abcc8) expression. Moreover, the effect was cell specific as neither HDI markedly altered K-ATP subunit expression in MIN6 pancreatic We observe significant enrichment of the H3K9Ac histone mark specifically at the SUR2 promoter consistent with the conclusion that chromatin remodeling at this locus plays a role in increasing SUR2 gene expression. Unexpectedly, however, we also discovered that HDI-dependent depletion of cellular cholesterol is required for the observed effects on SUR2 expression. Taken together, the data in the present study demonstrate that K-ATP subunit expression can be epigenetically regulated in cardiomyocytes, defines a role for cholesterol homeostasis in mediating epigenetic regulation and suggests a potential molecular basis for the cardiac effects of the HDIs.
C1 [Fatima, Naheed; Cohen, Devin C.; Sukumar, Gauthaman; Schooley, James F., Jr.; Dalgard, Clifton L.; Flagg, Thomas P.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
   [Sissung, Tristan M.; Bates, Susan E.] NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA.
   [Haigney, Mark C.] Uniformed Serv Univ Hlth Sci, Dept Med, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
   [Claycomb, William C.] LSU Hlth Sci Ctr, Dept Biochem & Mol Biol, New Orleans, LA USA.
   [Cox, Rachel T.] Uniformed Serv Univ Hlth Sci, Dept Biochem, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
RP Flagg, TP (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, 4301 Jones Bridge Rd,Rm C-2114, Bethesda, MD 20814 USA.
EM thomas.flagg@usuhs.edu
FU Biomedical Instrumentation Center at USUHS; American Heart Association
   Scientist Development Grant [11SDG7210070]; Department of Defense
   [R0702O]
FX The authors thank the Biomedical Instrumentation Center at USUHS for
   providing advanced microscope technology and support for imaging
   experiments. This work was supported by awards from the American Heart
   Association Scientist Development Grant (11SDG7210070 to TF) and the
   Department of Defense (R0702O to TF).
NR 60
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U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 13
PY 2015
VL 6
AR 168
DI 10.3389/fphar.2015.00168
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CX1EM
UT WOS:000365439200001
PM 26321954
ER

PT J
AU Nicolae, A
   Pittaluga, S
   Abdullah, S
   Steinberg, SM
   Pham, TA
   Davies-Hill, T
   Xi, LQ
   Raffeld, M
   Jaffe, ES
AF Nicolae, Alina
   Pittaluga, Stefania
   Abdullah, Shahed
   Steinberg, Seth M.
   Thu Anh Pham
   Davies-Hill, Theresa
   Xi, Liqiang
   Raffeld, Mark
   Jaffe, Elaine S.
TI EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma
   with evidence for a tolerogenic immune environment
SO BLOOD
LA English
DT Article
ID EPSTEIN-BARR-VIRUS; GRAY-ZONE LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS;
   INDOLEAMINE 2,3-DIOXYGENASE; ELDERLY-PATIENTS; WESTERN COUNTRIES;
   HODGKINS LYMPHOMA; EXPRESSION; RITUXIMAB; ENTITY
AB Few studies have reported Epstein-Barr virus-positive (EBV+) large B-cell lymphomas (LBCLs) in young patients without immunodeficiency. We identified 46 such cases in patients <= 45 years of age and analyzed the clinical and pathological characteristics. EBV+ LBCLs affected predominantly males (male: female = 3.6:1), with a median age of 23 years (range, 4-45 years). All patients presented with lymphadenopathy and 11% also had extranodal disease. Morphologically, 3 patterns were identified: T-cell/histiocyte-rich large B-cell lymphoma-like (n = 36), gray zone lymphoma (n = 7), and diffuse LBCL-not otherwise specified (n = 3). Tumor cells (EBV+ in >90% of cells) expressed B-cell antigens, were often CD30 and PD-L1 positive, and showed a nongerminal center immunophenotype. A total of 93% expressed EBV latency type II and 7% latency type III. Indoleamine 2,3-dioxygenase was expressed on background accessory cells. The most common treatment regimen was rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (58%), with local radiation therapy added in 21%. With a median follow-up of 22 months, 82% of patients are in clinical remission and only 8% died of disease. Younger patients achieved a significantly higher overall survival than prior series of EBV 1 LBCLs reported in the elderly (P < .0001). In conclusion, EBV 1 LBCLs are not restricted to the elderly. Young patients present with nodal disease and have a good prognosis.
C1 [Nicolae, Alina; Pittaluga, Stefania; Abdullah, Shahed; Davies-Hill, Theresa; Jaffe, Elaine S.] NCI, Hematopathol Sect, Pathol Lab, Bethesda, MD 20892 USA.
   [Steinberg, Seth M.] NCI, Biostat & Data Management Sect, Off Clin Director, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Thu Anh Pham; Xi, Liqiang; Raffeld, Mark] NCI, Mol Diagnost Unit, Pathol Lab, Bethesda, MD 20892 USA.
RP Jaffe, ES (reprint author), NCI, Hematopathol Sect, Pathol Lab, 10 Ctr Dr,Bldg 10,MSC 1500, Bethesda, MD 20892 USA.
EM elainejaffe@nih.gov
FU Center for Cancer Research, National Cancer Institute, National
   Institutes of Health
FX This study was supported by the intramural research program of the
   Center for Cancer Research, National Cancer Institute, National
   Institutes of Health.
NR 46
TC 21
Z9 23
U1 1
U2 5
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD AUG 13
PY 2015
VL 126
IS 7
BP 863
EP 872
DI 10.1182/blood-2015-02-630632
PG 10
WC Hematology
SC Hematology
GA CQ3VC
UT WOS:000360530800009
PM 25999451
ER

PT J
AU Aiden, EL
   Casellas, R
AF Aiden, Erez Lieberman
   Casellas, Rafael
TI Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics
SO CELL
LA English
DT Review
ID V(D)J RECOMBINATION; HUMAN GENOME; DNA BREAKS; REVEALS; TRANSLOCATIONS;
   MECHANISMS; LYMPHOCYTES; PRINCIPLES; LOCUS
AB We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.
C1 [Aiden, Erez Lieberman] Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
   [Casellas, Rafael] NIAMS, Genom & Immun, Bethesda, MD 20892 USA.
   [Casellas, Rafael] NCI, NIH, Bethesda, MD 20892 USA.
RP Casellas, R (reprint author), NIAMS, Genom & Immun, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM rafael.casellas@nih.gov
FU Intramural NIH HHS [Z01 AR041148-04]
NR 17
TC 3
Z9 3
U1 2
U2 13
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 708
EP 711
DI 10.1016/j.cell.2015.07.034
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400006
PM 26276627
ER

PT J
AU Volkow, ND
   Morales, M
AF Volkow, Nora D.
   Morales, Marisela
TI The Brain on Drugs: From Reward to Addiction
SO CELL
LA English
DT Review
ID VENTRAL TEGMENTAL AREA; DOPAMINE D2 RECEPTORS;
   POSITRON-EMISSION-TOMOGRAPHY; COCAINE-INDUCED PLASTICITY; MEDIAL
   PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS SHELL; DORSAL STRIATUM; SYNAPTIC
   PLASTICITY; LATERAL HABENULA; ORBITOFRONTAL CORTEX
AB Advances in neuroscience identified addiction as a chronic brain disease with strong genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit-and cell-level mechanisms of this condition and its co-option of pathways regulating reward, self-control, and affect. Drugs of abuse exert their initial reinforcing effects by triggering supraphysiologic surges of dopamine in the nucleus accumbens that activate the direct striatal pathway via D1 receptors and inhibit the indirect striato-cortical pathway via D2 receptors. Repeated drug administration triggers neuroplastic changes in glutamatergic inputs to the striatum and midbrain dopamine neurons, enhancing the brain's reactivity to drug cues, reducing the sensitivity to non-drug rewards, weakening self-regulation, and increasing the sensitivity to stressful stimuli and dysphoria. Drug-induced impairments are long lasting; thus, interventions designed to mitigate or even reverse them would be beneficial for the treatment of addiction.
C1 [Volkow, Nora D.; Morales, Marisela] NIDA, NIH, Bethesda, MD 20892 USA.
RP Volkow, ND (reprint author), NIDA, NIH, Bethesda, MD 20892 USA.
EM nvolkow@nida.nih.gov
NR 170
TC 55
Z9 55
U1 14
U2 117
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 712
EP 725
DI 10.1016/j.cell.2015.07.046
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400007
PM 26276628
ER

PT J
AU Robbiani, DF
   Deroubaix, S
   Feldhahn, N
   Oliveira, TY
   Callen, E
   Wang, Q
   Jankovic, M
   Silva, IT
   Rommel, PC
   Bosque, D
   Eisenreich, T
   Nussenzweig, A
   Nussenzweig, MC
AF Robbiani, Davide F.
   Deroubaix, Stephanie
   Feldhahn, Niklas
   Oliveira, Thiago Y.
   Callen, Elsa
   Wang, Qiao
   Jankovic, Mila
   Silva, Israel T.
   Rommel, Philipp C.
   Bosque, David
   Eisenreich, Tom
   Nussenzweig, Andre
   Nussenzweig, Michel C.
TI Plasmodium Infection Promotes Genomic Instability and AID-Dependent B
   Cell Lymphoma
SO CELL
LA English
DT Article
ID INDUCED CYTIDINE DEAMINASE; CLASS SWITCH RECOMBINATION; C-MYC ONCOGENE;
   BURKITT-LYMPHOMA; CHROMOSOMAL TRANSLOCATIONS; SEQUENCING REVEALS;
   GERMINAL-CENTERS; IMMUNE-RESPONSE; TRANSGENIC MICE; FRAGILE SITES
AB Chronic infection with Plasmodium falciparum was epidemiologically associated with endemic Burkitt's lymphoma, a mature B cell cancer characterized by chromosome translocation between the c-myc oncogene and Igh, over 50 years ago. Whether infection promotes B cell lymphoma, and if so by which mechanism, remains unknown. To investigate the relationship between parasitic disease and lymphomagenesis, we used Plasmodium chabaudi (Pc) to produce chronic malaria infection in mice. Pc induces prolonged expansion of germinal centers (GCs), unique compartments in which B cells undergo rapid clonal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator. GC B cells elicited during Pc infection suffer widespread DNA damage, leading to chromosome translocations. Although infection does not change the overall rate, it modifies lymphomagenesis to favor mature B cell lymphomas that are AID dependent and show chromosome translocations. Thus, malaria infection favors mature B cell cancers by eliciting protracted AID expression in GC B cells.
C1 [Robbiani, Davide F.; Deroubaix, Stephanie; Feldhahn, Niklas; Oliveira, Thiago Y.; Wang, Qiao; Jankovic, Mila; Silva, Israel T.; Rommel, Philipp C.; Bosque, David; Eisenreich, Tom; Nussenzweig, Michel C.] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA.
   [Nussenzweig, Michel C.] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA.
   [Callen, Elsa; Nussenzweig, Andre] NCI, Lab Genome Integr, NIH, Bethesda, MD 20892 USA.
RP Robbiani, DF (reprint author), Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA.
EM drobbiani@rockefeller.edu; nussen@rockefeller.edu
RI Silva, Israel/N-3858-2014; 
OI Silva, Israel/0000-0002-4687-1499; Rommel, Philipp/0000-0002-9790-4086
FU Worldwide Cancer Research [11-0022]; Fondazione Ettore e Valeria Rossi;
   NIH [AI112602, AI037526, AI072529]; NIH, the National Cancer Institute,
   the Center for Cancer Research; Department of Defense grant (BCRP DOD
   Idea Expansion Award) [11557134]
FX The authors thank members of the lab for discussions and suggestions,
   the MR4 for providing the malaria parasites contributed by Drs. W.
   Peters, B. Robinson, and I. Landau, Dr. Frank Costantini for providing
   the ROSA26-targeting plasmids, and Dr. Rafael Casellas for
   AID<SUP>GFP</SUP> mice. A particular thank you goes to Klara Velinzon
   and Yelena Shatalina for FACS sorting and one goes to Ariel
   Halper-Stromberg for help with Figure 2. Moreover, the authors are
   thankful to Dr. Julie White (Laboratory of Comparative Pathology,
   Memorial Sloan-Kettering Cancer Center) for histopathological
   evaluation. This work was supported by a grant (11-0022) from Worldwide
   Cancer Research (formerly known as Association for International Cancer
   Research), by the Fondazione Ettore e Valeria Rossi, and by an NIH grant
   (AI112602) (to D.F.R.). This work was also supported in part by NIH
   grants (AI037526 and AI072529) (to M.C.N.). A.N. and E.C. are supported
   by the Intramural Research Program of the NIH, the National Cancer
   Institute, the Center for Cancer Research, and a Department of Defense
   grant (BCRP DOD Idea Expansion Award, grant 11557134). N.F. is a Bennett
   Fellow of Leukaemia and Lymphoma Research. M.C.N. is an HHMI
   Investigator. This manuscript is dedicated to Georg Klein on the
   occasion of his 90th birthday.
NR 73
TC 29
Z9 29
U1 3
U2 26
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 727
EP 737
DI 10.1016/j.cell.2015.07.019
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400008
PM 26276629
ER

PT J
AU Andersen, KG
   Shapiro, BJ
   Matranga, CB
   Sealfon, R
   Lin, AE
   Moses, LM
   Folarin, OA
   Goba, A
   Odia, I
   Ehiane, PE
   Momoh, M
   England, EM
   Winnicki, S
   Branco, LM
   Gire, SK
   Phelan, E
   Tariyal, R
   Tewhey, R
   Omoniwa, O
   Fullah, M
   Fonnie, R
   Fonnie, M
   Kanneh, L
   Jalloh, S
   Gbakie, M
   Saffa, S
   Karbo, K
   Gladden, AD
   Qu, J
   Stremlau, M
   Nekoui, M
   Finucane, HK
   Tabrizi, S
   Vitti, JJ
   Birren, B
   Fitzgerald, M
   McCowan, C
   Ireland, A
   Berlin, AM
   Bochicchio, J
   Tazon-Vega, B
   Lennon, NJ
   Ryan, EM
   Bjornson, Z
   Milner, DA
   Lukens, AK
   Broodie, N
   Rowland, M
   Heinrich, M
   Akdag, M
   Schieffelin, JS
   Levy, D
   Akpan, H
   Bausch, DG
   Rubins, K
   McCormick, JB
   Lander, ES
   Gunther, S
   Hensley, L
   Okogbenin, S
   Schaffner, SF
   Okokhere, PO
   Khan, SH
   Grant, DS
   Akpede, GO
   Asogun, DA
   Gnirke, A
   Levin, JZ
   Happi, CT
   Garry, RF
   Sabeti, PC
AF Andersen, Kristian G.
   Shapiro, B. Jesse
   Matranga, Christian B.
   Sealfon, Rachel
   Lin, Aaron E.
   Moses, Lina M.
   Folarin, Onikepe A.
   Goba, Augustine
   Odia, Ikponmwonsa
   Ehiane, Philomena E.
   Momoh, Mambu
   England, Eleina M.
   Winnicki, Sarah
   Branco, Luis M.
   Gire, Stephen K.
   Phelan, Eric
   Tariyal, Ridhi
   Tewhey, Ryan
   Omoniwa, Omowunmi
   Fullah, Mohammed
   Fonnie, Richard
   Fonnie, Mbalu
   Kanneh, Lansana
   Jalloh, Simbirie
   Gbakie, Michael
   Saffa, Sidiki
   Karbo, Kandeh
   Gladden, Adrianne D.
   Qu, James
   Stremlau, Matthew
   Nekoui, Mahan
   Finucane, Hilary K.
   Tabrizi, Shervin
   Vitti, Joseph J.
   Birren, Bruce
   Fitzgerald, Michael
   McCowan, Caryn
   Ireland, Andrea
   Berlin, Aaron M.
   Bochicchio, James
   Tazon-Vega, Barbara
   Lennon, Niall J.
   Ryan, Elizabeth M.
   Bjornson, Zach
   Milner, Danny A., Jr.
   Lukens, Amanda K.
   Broodie, Nisha
   Rowland, Megan
   Heinrich, Megan
   Akdag, Marjan
   Schieffelin, John S.
   Levy, Danielle
   Akpan, Henry
   Bausch, Daniel G.
   Rubins, Kathleen
   McCormick, Joseph B.
   Lander, Eric S.
   Guenther, Stephan
   Hensley, Lisa
   Okogbenin, Sylvanus
   Schaffner, Stephen F.
   Okokhere, Peter O.
   Khan, S. Humarr
   Grant, Donald S.
   Akpede, George O.
   Asogun, Danny A.
   Gnirke, Andreas
   Levin, Joshua Z.
   Happi, Christian T.
   Garry, Robert F.
   Sabeti, Pardis C.
CA Viral Hemorrhagic Fever Consortium
TI Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
SO CELL
LA English
DT Article
ID WEST-AFRICA; CODON USAGE; PURIFYING SELECTION; DENGUE VIRUS; L-RNA;
   FEVER; BIAS; ADAPTATION; ANCIENT; EBOLA
AB The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics.
C1 [Andersen, Kristian G.; Shapiro, B. Jesse; Lin, Aaron E.; Winnicki, Sarah; Gire, Stephen K.; Tewhey, Ryan; Stremlau, Matthew; Nekoui, Mahan; Tabrizi, Shervin; Vitti, Joseph J.; Sabeti, Pardis C.] Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA.
   [Andersen, Kristian G.; Shapiro, B. Jesse; Matranga, Christian B.; Sealfon, Rachel; Lin, Aaron E.; England, Eleina M.; Winnicki, Sarah; Gire, Stephen K.; Phelan, Eric; Tariyal, Ridhi; Tewhey, Ryan; Gladden, Adrianne D.; Qu, James; Stremlau, Matthew; Nekoui, Mahan; Finucane, Hilary K.; Tabrizi, Shervin; Birren, Bruce; Fitzgerald, Michael; McCowan, Caryn; Ireland, Andrea; Berlin, Aaron M.; Bochicchio, James; Tazon-Vega, Barbara; Lennon, Niall J.; Ryan, Elizabeth M.; Lander, Eric S.; Schaffner, Stephen F.; Gnirke, Andreas; Levin, Joshua Z.; Sabeti, Pardis C.] Broad Inst, Cambridge, MA 02142 USA.
   [Andersen, Kristian G.] Scripps Translat Sci Inst, Scripps Res Inst, La Jolla, CA 92037 USA.
   [Shapiro, B. Jesse] Univ Montreal, Dept Biol Sci, Montreal, PQ H2V 2S9, Canada.
   [Sealfon, Rachel] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
   [Moses, Lina M.; Schieffelin, John S.; Levy, Danielle; Bausch, Daniel G.; Garry, Robert F.] Tulane Univ, Tulane Hlth Sci Ctr, New Orleans, LA 70118 USA.
   [Folarin, Onikepe A.; Odia, Ikponmwonsa; Ehiane, Philomena E.; Omoniwa, Omowunmi; Okogbenin, Sylvanus; Okokhere, Peter O.; Akpede, George O.; Asogun, Danny A.; Happi, Christian T.] Irrua Specialist Teaching Hosp, Inst Lassa Fever Res & Control, Irrua, Edo State, Nigeria.
   [Folarin, Onikepe A.; Happi, Christian T.] Redeemers Univ, Coll Nat Sci, Dept Biol Sci, Redemption City, Osun State, Nigeria.
   [Goba, Augustine; Momoh, Mambu; Fullah, Mohammed; Fonnie, Richard; Fonnie, Mbalu; Kanneh, Lansana; Jalloh, Simbirie; Gbakie, Michael; Saffa, Sidiki; Karbo, Kandeh; Khan, S. Humarr; Grant, Donald S.] Kenema Govt Hosp, Lassa Fever Lab, Kenema, Eastern Provinc, Sierra Leone.
   [Momoh, Mambu; Fullah, Mohammed] Eastern Polytech Coll, Kenema, Eastern Provinc, Sierra Leone.
   [Branco, Luis M.; Rowland, Megan; Heinrich, Megan; Akdag, Marjan] Zalgen Labs, Germantown, MD 20876 USA.
   [Bjornson, Zach] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94304 USA.
   [Milner, Danny A., Jr.; Lukens, Amanda K.; Sabeti, Pardis C.] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
   [Broodie, Nisha] Columbia Univ, Coll Med, New York, NY 10032 USA.
   [Akpan, Henry] Nigerian Fed Minist Hlth, Abuja, Fed Capital Ter, Nigeria.
   [Rubins, Kathleen] NASA, Johnson Space Ctr, Houston, TX 77058 USA.
   [McCormick, Joseph B.] Univ Texas Sch Publ Hlth, Brownsville, TX 77030 USA.
   [Guenther, Stephan] Bernhard Nocht Inst Trop Med, Dept Virol, D-20259 Hamburg, Germany.
   [Hensley, Lisa] NIAID Integrated Res Facil, Frederick, MD 21702 USA.
   [Viral Hemorrhagic Fever Consortium] Tulane Univ, New Orleans, LA 70118 USA.
RP Sabeti, PC (reprint author), Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA.
RI Tazon Vega, Barbara/J-6739-2015; Schaffner, Stephen/D-1189-2011; 
OI Tazon Vega, Barbara/0000-0003-4513-5104; Shapiro, B.
   Jesse/0000-0001-6819-8699; Broodie, Nisha/0000-0001-6911-328X; Branco,
   Luis/0000-0001-8161-0182
FU NIH; Department of Health and Human Services [1DP2OD006514-01]; NIAID
   [HHSN272200900049C, HHSN272201000022C, HHSN272200900018C, U19AI110818];
   USAMRAA [W81XWH-10-1-0098]; Packard Foundation Fellowship for Science
   and Engineering; Broad Institute SPARC award; German Research Foundation
   [GU 883/1-1]; Carlsberg Foundation; Harvard MIDAS CCDD postdoctoral
   fellowship; Canada Research Chair; NSF [DGE 1122374, 1144152]
FX The authors thank C. Edwards, X. Yang, M. Zody, B. Han, A. Andersen, I.
   Shlyakhter, D. Park, M. Henn, M. Busby, M. Kellis, C. Bishop, A.
   Haislip, L. Burchfield, A. Matthews, and F. Viloria for their help and
   advice. We also thank the Ministry of Health and Sanitation Government
   of Sierra Leone, Oyo State Ministry of Health, and the Federal Ministry
   of Health, Nigeria. A full list of members of the Viral Hemorrhagic
   Fever Consortium can be found at www.vhfc.org. This project was funded
   with federal funds from the NIH, Department of Health and Human Services
   (1DP2OD006514-01) and NIAID Contracts (HHSN272200900049C,
   HHSN272201000022C, HHSN272200900018C, and U19AI110818). The authors
   received additional support from USAMRAA (W81XWH-10-1-0098), a Packard
   Foundation Fellowship for Science and Engineering, a Broad Institute
   SPARC award, and the German Research Foundation (GU 883/1-1). K.G.A. was
   supported by a fellowship from the Carlsberg Foundation; B.J.S. was
   supported by a Harvard MIDAS CCDD postdoctoral fellowship and Canada
   Research Chair; and R.S. and A.E.L. received NSF GRFP fellowships (DGE
   1122374 and 1144152). Tulane University and industry partners have filed
   patent applications for several Lassa-related technologies and may
   receive royalties or profits if commercial products are developed.
NR 51
TC 21
Z9 21
U1 5
U2 62
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 738
EP 750
DI 10.1016/j.cell.2015.07.020
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400009
PM 26276630
ER

PT J
AU Teng, G
   Maman, Y
   Resch, W
   Kim, M
   Yamane, A
   Qian, J
   Kieffer-Kwon, KR
   Mandal, M
   Ji, YH
   Meffre, E
   Clark, MR
   Cowell, LG
   Casellas, R
   Schatz, DG
AF Teng, Grace
   Maman, Yaakov
   Resch, Wolfgang
   Kim, Min
   Yamane, Arito
   Qian, Jason
   Kieffer-Kwon, Kyong-Rim
   Mandal, Malay
   Ji, Yanhong
   Meffre, Eric
   Clark, Marcus R.
   Cowell, Lindsay G.
   Casellas, Rafael
   Schatz, David G.
TI RAG Represents a Widespread Threat to the Lymphocyte Genome
SO CELL
LA English
DT Article
ID ILLEGITIMATE V(D)J RECOMBINATION; HISTONE H3; CHROMOSOMAL
   TRANSLOCATIONS; INTRAGENIC DELETIONS; THYMIC LYMPHOMAS; B-CELL;
   REARRANGEMENT; GENE; MECHANISMS; MOUSE
AB The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic'' recombination signals near RAG1 binding sites. This depletion operates specifically on the RSS heptamer, whereas nonamers are enriched at RAG1 binding sites. Reversing this RAG-driven depletion of cleavage sites by insertion of strong recombination signals creates an ectopic hub of RAG-mediated V(D)J recombination and chromosomal translocations. Our findings delineate rules governing RAG binding in the genome, identify areas at risk of RAG-mediated damage, and highlight the evolutionary struggle to accommodate programmed DNA damage in developing lymphocytes.
C1 [Teng, Grace; Maman, Yaakov; Meffre, Eric; Schatz, David G.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA.
   [Resch, Wolfgang; Yamane, Arito; Qian, Jason; Kieffer-Kwon, Kyong-Rim; Casellas, Rafael] NCI, Genom & Immun, NIAMS, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
   [Kim, Min; Cowell, Lindsay G.] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Div Biomed Informat, Dallas, TX 75390 USA.
   [Mandal, Malay; Clark, Marcus R.] Univ Chicago, Rheumatol Sect, Dept Med, Chicago, IL 60637 USA.
   [Mandal, Malay; Clark, Marcus R.] Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA.
   [Ji, Yanhong] Xi An Jiao Tong Univ, Coll Med, Dept Immunol & Microbiol, Xian 710061, Shaanxi, Peoples R China.
   [Schatz, David G.] Howard Hughes Med Inst, New Haven, CT 06511 USA.
RP Casellas, R (reprint author), NCI, Genom & Immun, NIAMS, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
EM casellar@mail.nih.gov; david.schatz@yale.edu
FU NIH NRSA Institutional Postdoctoral Training Grant [T32 AI007019];
   Cancer Research Institute Irvington Postdoctoral Fellowship; NIAMS, NIH;
   Burroughs Wellcome Fund Career Award;  [R37 AI32524];  [R01 GM0888847]
FX The authors thank S. Zhou for assistance with mice, E. Corbett for
   antibody production, Y. Zhang and F. Alt for the Atm<SUP>-/-</SUP>
   I-SceI v-abl cell line, J. Henao-Meija for the CRISPR/Cas9 guide RNA
   sequence for Hprt, and S. Smale and J. Langermann for valuable advice.
   This work was supported in part by an NIH NRSA Institutional
   Postdoctoral Training Grant (T32 AI007019) and a Cancer Research
   Institute Irvington Postdoctoral Fellowship (G.T.), R37 AI32524
   (D.G.S.), R01 GM0888847 (M.C.), by the Intramural Research Program of
   NIAMS, NIH (R.C.), and by a Burroughs Wellcome Fund Career Award
   (L.G.C.). D.G.S. is an investigator of the Howard Hughes Medical
   Institute. This study used high-performance computational capabilities
   of the NIH Biowulf Linux cluster.
NR 47
TC 27
Z9 27
U1 1
U2 10
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 751
EP 765
DI 10.1016/j.cell.2015.07.009
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400010
PM 26234156
ER

PT J
AU Young, DJ
   Guydosh, NR
   Zhang, F
   Hinnebusch, AG
   Green, R
AF Young, David J.
   Guydosh, Nicholas R.
   Zhang, Fan
   Hinnebusch, Alan G.
   Green, Rachel
TI Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation
   Reinitiation in 3 ' UTRs In Vivo
SO CELL
LA English
DT Article
ID EUKARYOTIC TRANSLATION; MESSENGER-RNA; DISSOCIATION; INITIATION;
   COMPLEXES; SUBUNITS; BINDING; BIOSYNTHESIS; RECOGNITION; RESOLUTION
AB To study the function of Rli1/ABCE1 in vivo, we used ribosome profiling and biochemistry to characterize its contribution to ribosome recycling. When Rli1 levels were diminished, 80S ribosomes accumulated both at stop codons and in the adjoining 3'UTRs of most mRNAs. Frequently, these ribosomes reinitiated translation without the need for a canonical start codon, as small peptide products predicted by 3'UTR ribosome occupancy in all three reading frames were confirmed by western analysis and mass spectrometry. Eliminating the ribosome-rescue factor Dom34 dramatically increased 3'UTR ribosome occupancy in Rli1 depleted cells, indicating that Dom34 clears the bulk of unrecycled ribosomes. Thus, Rli1 is crucial for ribosome recycling in vivo and controls ribosome homeostasis. 3'UTR translation occurs in wild-type cells as well, and observations of elevated 3'UTR ribosomes during stress suggest that modulating recycling and reinitiation is involved in responding to environmental changes.
C1 [Young, David J.; Zhang, Fan; Hinnebusch, Alan G.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA.
   [Guydosh, Nicholas R.; Green, Rachel] Johns Hopkins Univ, Howard Hughes Med Inst, Sch Med, Baltimore, MD 21205 USA.
RP Hinnebusch, AG (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA.
EM ahinnebusch@nih.gov; ragreen@jhmi.edu
FU Intramural Research Program of the NIH; HHMI
FX Proteomics data and analysis were performed by Susan Fishbain, Paige
   Gottlieb, Ioanna Ntai, and Paul Thomas of the Proteomics Center of
   Excellence at Northwestern University. We thank Tom Dever, Jon Lorsch,
   and members of our laboratories for many helpful suggestions during the
   course of this work. This study was funded in part by the Intramural
   Research Program of the NIH (A.G.H.) and by HHMI (R.G.).
NR 40
TC 22
Z9 22
U1 7
U2 29
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 872
EP 884
DI 10.1016/j.cell.2015.07.041
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400019
PM 26276635
ER

PT J
AU Shachar, S
   Voss, TC
   Pegoraro, G
   Sciascia, N
   Misteli, T
AF Shachar, Sigal
   Voss, Ty C.
   Pegoraro, Gianluca
   Sciascia, Nicholas
   Misteli, Tom
TI Identification of Gene Positioning Factors Using High-Throughput Imaging
   Mapping
SO CELL
LA English
DT Article
ID RECURRENT CHROMOSOMAL TRANSLOCATIONS; SPATIAL GENOME ORGANIZATION;
   NUCLEAR LAMINA INTERACTIONS; HUMAN-CELLS; EARLY G1; CHROMATIN;
   REORGANIZATION; ARCHITECTURE; MITOSIS; LOCUS
AB Genomes are arranged non-randomly in the 3D space of the cell nucleus. Here, we have developed HIPMap, a high-precision, high-throughput, automated fluorescent in situ hybridization imaging pipeline, for mapping of the spatial location of genome regions at large scale. High-throughput imaging position mapping (HIPMap) enabled an unbiased siRNA screen for factors involved in genome organization in human cells. We identify 50 cellular factors required for proper positioning of a set of functionally diverse genomic loci. Positioning factors include chromatin remodelers, histone modifiers, and nuclear envelope and pore proteins. Components of the replication and post-replication chromatin reassembly machinery are prominently represented among positioning factors, and timely progression of cells through replication, but not mitosis, is required for correct gene positioning. Our results establish a method for the large-scale mapping of genome locations and have led to the identification of a compendium of cellular factors involved in spatial genome organization.
C1 [Shachar, Sigal; Sciascia, Nicholas; Misteli, Tom] NCI, NIH, Bethesda, MD 20892 USA.
   [Voss, Ty C.; Pegoraro, Gianluca] NCI, High Throughput Imaging Facil HiTIF, NIH, Bethesda, MD 20892 USA.
RP Misteli, T (reprint author), NCI, NIH, Bethesda, MD 20892 USA.
EM mistelit@mail.nih.gov
OI Pegoraro, Gianluca/0000-0003-2843-9464
FU Intramural Research Program of the National Institutes of Health (NIH),
   NCI; Center for Cancer Research
FX We thank Karen Meaburn for insightful suggestions for developing hiFISH,
   members of the Misteli laboratory for helpful discussions and comments,
   Laurent Ozbun from the NCI HiTIF for technical assistance with the
   screen, and Murali Palangat for help with polymerase II activity assays.
   This research was supported by the Intramural Research Program of the
   National Institutes of Health (NIH), NCI, and Center for Cancer
   Research. T.C.V. is an employee of Perkin Elmer Cooperation.
NR 53
TC 29
Z9 30
U1 1
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD AUG 13
PY 2015
VL 162
IS 4
BP 911
EP 923
DI 10.1016/j.cell.2015.07.035
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CP2XP
UT WOS:000359741400022
PM 26276637
ER

PT J
AU La Regina, G
   Bai, RL
   Coluccia, A
   Farniglini, V
   Pelliccia, S
   Passacantilli, S
   Mazzoccoli, C
   Ruggieri, V
   Verrico, A
   Miele, A
   Monti, L
   Nalli, M
   Alfonsi, R
   Di Marcotullio, L
   Gulino, A
   Ricci, B
   Soriani, A
   Santoni, A
   Caraglia, M
   Porto, S
   Da Pozzo, E
   Martini, C
   Brancale, A
   Marinelli, L
   Novellino, E
   Vultaggio, S
   Varasi, M
   Mercurio, C
   Bigogno, C
   Dondio, G
   Hamel, E
   Lavia, P
   Silvestri, R
AF La Regina, Giuseppe
   Bai, Ruoli
   Coluccia, Antonio
   Farniglini, Valeria
   Pelliccia, Sveva
   Passacantilli, Sara
   Mazzoccoli, Carmela
   Ruggieri, Vitalba
   Verrico, Annalisa
   Miele, Andrea
   Monti, Ludovica
   Nalli, Marianna
   Alfonsi, Romina
   Di Marcotullio, Lucia
   Gulino, Alberto
   Ricci, Biancamaria
   Soriani, Alessandra
   Santoni, Angela
   Caraglia, Michele
   Porto, Stefania
   Da Pozzo, Eleonora
   Martini, Claudia
   Brancale, Andrea
   Marinelli, Luciana
   Novellino, Ettore
   Vultaggio, Stefania
   Varasi, Mario
   Mercurio, Ciro
   Bigogno, Chiara
   Dondio, Giulio
   Hamel, Ernest
   Lavia, Patrizia
   Silvestri, Romano
TI New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic
   Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic
   Activity, and Repression of Hedgehog-Dependent Cancer
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID POTENT INHIBITORS; ANTICANCER AGENTS; COLCHICINE SITE; MICROTUBULE;
   POLYMERIZATION; DERIVATIVES; ANALOGS; LINES; ARYLTHIOINDOLES;
   CYCLIZATION
AB We designed 39 new 2-phenylindole derivatives as potential anticancer agents bearing the 3,4,5-trimethoxyphenyl moiety with a sulfur, ketone, or methylene bridging group at position 3 of the indole and with halogen or methoxy substituent(s) at positions 4-7. Compounds 33 and 44 strongly inhibited the growth of the P-glycoprotein-overexpressing multi-drug-resistant cell lines NCI/ADR-RES and Messa/Dx5. At 10 nM, 33 and 44 stimulated the cytotoxic activity of NK cells. At 20-50 nM, 33 and 44 arrested >80% of HeLa cells in the G2/M phase of the cell cycle, with stable arrest of mitotic progression. Cell cycle arrest was followed by cell death. Indoles 33, 44, and 81 showed strong inhibition of the SAG-induced Hedgehog signaling activation in NIH3T3 Shh-Light II cells with IC50 values of 19, 72, and 38 nM, respectively. Compounds of this class potently inhibited tubulin polymerization and cancer cell growth, including stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer.
C1 [La Regina, Giuseppe; Coluccia, Antonio; Farniglini, Valeria; Passacantilli, Sara; Monti, Ludovica; Nalli, Marianna; Silvestri, Romano] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, Fdn Cenci Bolognetti, Ist Pasteur, I-00185 Rome, Italy.
   [Bai, Ruoli; Hamel, Ernest] NCI, Screening Technol Branch, Dev Therapeut Program,NIH, Div Canc Treatment & Diag,Frederick Natl Lab Canc, Ft Detrick, MD 21702 USA.
   [Pelliccia, Sveva; Marinelli, Luciana; Novellino, Ettore] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy.
   [Mazzoccoli, Carmela; Ruggieri, Vitalba] IRCCS, Ctr Riferimento Oncol Basilicata, Lab Ric Preclin Traslaz, I-85028 Rionero In Vulture, Italy.
   [Verrico, Annalisa; Miele, Andrea; Santoni, Angela; Lavia, Patrizia] Univ Roma La Sapienza, CNR, Inst Mol Biol & Pathol, I-00185 Rome, Italy.
   [Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Ricci, Biancamaria; Soriani, Alessandra; Santoni, Angela] Univ Roma La Sapienza, Fdn Cenci Bolognetti, Ist Pasteur, Dept Mol Med, I-00161 Rome, Italy.
   [Di Marcotullio, Lucia] Ist Italian Tecnol, Ctr Life NanoSci Sapienza, I-00161 Rome, Italy.
   [Caraglia, Michele; Porto, Stefania] Univ Naples 2, Dept Biochem Biophys & Gen Pathol, I-80138 Naples, Italy.
   [Da Pozzo, Eleonora; Martini, Claudia] Univ Pisa, Dept Pharm, I-56126 Pisa, Italy.
   [Brancale, Andrea] Cardiff Univ, Cardiff Sch Pharm & Pharmaceut Sci, Cardiff CF10 3NB, S Glam, Wales.
   [Vultaggio, Stefania; Varasi, Mario] European Inst Oncol, I-20139 Milan, Italy.
   [Mercurio, Ciro] DAC SRL, Genextra Grp, I-20139 Milan, Italy.
   [Bigogno, Chiara; Dondio, Giulio] APHAD Srl, I-20090 Buccinasco, Italy.
RP Silvestri, R (reprint author), Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, Fdn Cenci Bolognetti, Ist Pasteur, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM romano.silvestri@uniroma1.it
RI La Regina, Giuseppe/I-2161-2012; Da Pozzo, Eleonora/M-2215-2015;
   Caraglia, Michele/N-5670-2015; santoni, angela/K-8997-2016; Alfonsi,
   Romina/C-2641-2017; 
OI La Regina, Giuseppe/0000-0003-3252-1161; Da Pozzo,
   Eleonora/0000-0003-4762-8949; Caraglia, Michele/0000-0003-2408-6091;
   santoni, angela/0000-0003-1206-7731; /0000-0002-7940-8206; SORIANI,
   Alessandra/0000-0001-5461-9026; Martini, Claudia/0000-0001-9379-3027;
   Passacantilli, Sara/0000-0001-9781-0621; Nalli,
   Marianna/0000-0003-2774-6868; Silvestri, Romano/0000-0003-2489-0178;
   Alfonsi, Romina/0000-0001-5100-5491; Lavia, Patrizia/0000-0003-3310-6701
FU PRIN [2010W7YRLZ_001, 2010W7YRLZ_001006, 2012C5YJSK002]; Bando Futuro in
   Ricerca [RBFR10ZJQT]; Progetti di Ricerca di Universita; Sapienza
   Universita di Roma [C26H135FL5, C26A14TLFT]; Istituto Pasteur-Fondazione
   Cenci Bolognetti;  [AIRC IG 14534];  [AIRC IG 14723]; Associazione
   Italiana per la Ricerca sul Cancro
FX This research was supported by grants from PRIN 2010-2011
   (2010W7YRLZ_001 and 2010W7YRLZ_001006), PRIN 2012-2013 (2012C5YJSK002),
   Bando Futuro in Ricerca 2010 (RBFR10ZJQT), Progetti di Ricerca di
   Universita, Sapienza Universita di Roma (C26H135FL5 and C26A14TLFT), and
   the Istituto Pasteur-Fondazione Cenci Bolognetti and Grants AIRC IG
   14534 (P.L.) and AIRC IG 14723 (L.D.M.). We are grateful to Giulia
   Guarguaglini and Italia Anna Asteriti for microscopy analysis. We also
   thank Professor Claudia Piccoli and Dr. Matteo Landriscina, University
   of Foggia, Italy, for providing the cell lines. We are grateful to Dr.
   Enrico Cundari for help with the flow cytometric analysis.
NR 68
TC 10
Z9 10
U1 4
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD AUG 13
PY 2015
VL 58
IS 15
BP 5789
EP 5807
DI 10.1021/acs.jmedchem.5b00310
PG 19
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CP2BY
UT WOS:000359683700008
PM 26132075
ER

PT J
AU Cioffi, CL
   Racz, B
   Freeman, EE
   Conlon, MP
   Chen, P
   Stafford, DG
   Schwarz, DMC
   Zhu, L
   Kitchen, DB
   Barnes, KD
   Dobri, N
   Michelotti, E
   Cywin, CL
   Martin, WH
   Pearson, PG
   Johnson, G
   Petrukhin, K
AF Cioffi, Christopher L.
   Racz, Boglarka
   Freeman, Emily E.
   Conlon, Michael P.
   Chen, Ping
   Stafford, Douglas G.
   Schwarz, Daniel M. C.
   Zhu, Lei
   Kitchen, Douglas B.
   Barnes, Keith D.
   Dobri, Nicoleta
   Michelotti, Enrique
   Cywin, Charles L.
   Martin, William H.
   Pearson, Paul G.
   Johnson, Graham
   Petrukhin, Konstantin
TI Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol
   Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular
   Degeneration and Stargardt Disease
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID PIGMENT EPITHELIAL-CELLS; FUNDUS AUTOFLUORESCENCE; GEOGRAPHIC ATROPHY;
   VITAMIN-A; LIPOFUSCIN ACCUMULATION; SERUM RETINOL; MOUSE MODEL; IN-VIVO;
   A2E; TRANSTHYRETIN
AB Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of serum all-trans retinol (1) and have been shown to reduce cytotoxic bisretinoid formation in the retinal pigment epithelium (RPE), which is associated with the pathogenesis of both dry age-related macular degeneration (AIVID) and Stargardt disease. Thus, these agents show promise as a potential pharmacotherapy by which to stem further neurodegeneration and concomitant -vision loss associated with geographic atrophy of the macula. We previously disdosed the discovery of a novel series of nonretinoid RBP4 antagonists, represented by bicyclic [3.3.0]-octahydrocydopenta[c]pyrrolo analogue 4. We describe herein the utilization of a pyrimidine-4-carboxylic acid fragment as a suitable isostere for the anthranilic acid appendage of 4, which led to the discovery of standout antagonist 33. Analogue 33 possesses exquisite in vitro RBP4 binding affinity and favorable drug-like characteristics and was found to reduce circulating plasma RBP4 levels in vivo in a robust manner (>90%).
C1 [Cioffi, Christopher L.; Freeman, Emily E.; Conlon, Michael P.; Chen, Ping; Stafford, Douglas G.; Schwarz, Daniel M. C.; Barnes, Keith D.] AMRI, Dept Med Chem, Rensselaer, NY 12144 USA.
   [Zhu, Lei; Kitchen, Douglas B.] AMRI, Comp Assisted Drug Discovery, Rensselaer, NY 12144 USA.
   [Racz, Boglarka; Dobri, Nicoleta; Petrukhin, Konstantin] Columbia Univ, Med Ctr, Dept Ophthalmol, New York, NY 10032 USA.
   [Pearson, Paul G.; Johnson, Graham] iCuraVision LLC, Westlake Village, CA 91362 USA.
   [Martin, William H.] WHM Consulting LLC, Lyme, CT 06371 USA.
   [Michelotti, Enrique] NIMH, NIH, Bethesda, MD 20892 USA.
   [Cywin, Charles L.] NINDS, NIH, Bethesda, MD 20892 USA.
RP Cioffi, CL (reprint author), AMRI, Dept Med Chem, East Campus,3 Univ Pl, Rensselaer, NY 12144 USA.
EM christopher.cioffi@amriglobal.com; kep4@cumc.columbia.edu;
   kep4@cumc.columbia.edu
OI Kitchen, Douglas/0000-0001-8988-759X
FU NIH [U01 NS074476, P30 EY019007]; Research to Prevent Blindness (New
   York, NY); National Institute of Neurological Disorders and Stroke, the
   National Eye Institute, the NIH Blueprint Neurotherapeutics Network,
   Blueprint for Neuroscience Research Program, National Institutes of
   Health, Department of Health and Human Services [HHSN271201100013C]
FX This study was supported by NIH Grants U01 NS074476 (to K.P.), P30
   EY019007 (Core Support for Vision Research), and unrestricted funds from
   Research to Prevent Blindness (New York, NY) to the Department of
   Ophthalmology, Columbia University. We thank The Burch Family
   Foundation, the Mary Jaharis-John Catsimatidis Scholarship Fund, the
   Kaplen Foundation, and the Eye Surgery Fund for gifts supporting this
   study. This project has also been funded in whole or in part with
   Federal funds from the National Institute of Neurological Disorders and
   Stroke, the National Eye Institute, the NIH Blueprint Neurotherapeutics
   Network, Blueprint for Neuroscience Research Program, National
   Institutes of Health, Department of Health and Human Services, under
   Contract No. HHSN271201100013C.
NR 51
TC 3
Z9 3
U1 2
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD AUG 13
PY 2015
VL 58
IS 15
BP 5863
EP 5888
DI 10.1021/acs.jmedchem.5b00423
PG 26
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CP2BY
UT WOS:000359683700013
PM 26181715
ER

PT J
AU Yang, SM
   Yasgar, A
   Miller, B
   Lal-Nag, M
   Brimacombe, K
   Hu, X
   Sun, HM
   Wang, A
   Xu, X
   Nguyen, K
   Oppermann, U
   Ferrer, M
   Vasiliou, V
   Simeonov, A
   Jadhav, A
   Maloney, DJ
AF Yang, Shyh-Ming
   Yasgar, Adam
   Miller, Bettina
   Lal-Nag, Madhu
   Brimacombe, Kyle
   Hu, Xin
   Sun, Hongmao
   Wang, Amy
   Xu, Xin
   Nguyen, Kimloan
   Oppermann, Udo
   Ferrer, Marc
   Vasiliou, Vasilis
   Simeonov, Anton
   Jadhav, Ajit
   Maloney, David J.
TI Discovery of NCT-501, a Potent and Selective Theophylline-Based
   Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID CANCER STEM-CELLS; MOLECULAR-CLONING; HUMAN-MELANOMA; ALCOHOL;
   SUPERFAMILY; METABOLISM; DAIDZIN; DISEASE; ENZYMES; SEEKING
AB Aldehyde dehydrogenases (ALDHs) metabolize reactive aldehydes and possess important physiological and toxicological functions in areas such as CNS, metabolic disorders, and cancers. Increased ALDH (e.g., ALDH1A1) gene expression and catalytic activity are vital biomarkers in a number of malignancies and cancer stem cells, highlighting the need for the identification and development of small molecule ALDH inhibitors. A new series of theophylline-based analogs as potent ALDH1A1 inhibitors is described. The optimization of hits identified from a quantitative high throughput screening (qHTS) campaign led to analogs with improved potency and early ADME properties. This chemotype exhibits highly selective inhibition against ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as HPGD and HSD17 beta 4. Moreover, the pharrnacokinetic evaluation of selected analog 64 (NCT-501) is also highlighted.
C1 [Yang, Shyh-Ming; Yasgar, Adam; Lal-Nag, Madhu; Brimacombe, Kyle; Hu, Xin; Sun, Hongmao; Wang, Amy; Xu, Xin; Nguyen, Kimloan; Ferrer, Marc; Simeonov, Anton; Jadhav, Ajit; Maloney, David J.] NIH, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA.
   [Miller, Bettina; Vasiliou, Vasilis] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO 80045 USA.
   [Oppermann, Udo] NIHR Oxford Biomed Res Unit, Botnar Res Ctr, Oxford OX3 7LD, England.
   [Oppermann, Udo] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England.
   [Vasiliou, Vasilis] Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06510 USA.
RP Maloney, DJ (reprint author), NIH, Natl Ctr Adv Translat Sci, 9800 Med Ctr Dr, Rockville, MD 20850 USA.
EM yangs9@mail.nih.gov; maloneyd@mail.nih.gov
FU National Center for Advancing Translational Sciences; Molecular
   Libraries Initiative of the National Institutes of Health Roadmap for
   Medical Research [U54MH084681]; National Institutes of Health [AA022057,
   AA021724]
FX S.-M.Y, A.Y, M.L.-N., K.N., K.B., A.W., X.X., M.P., A.S., A.J, and
   D.J.M. were supported the intramural research program of the National
   Center for Advancing Translational Sciences and the Molecular Libraries
   Initiative of the National Institutes of Health Roadmap for Medical
   Research (Grant U54MH084681). The authors thank Sam Michael and Richard
   Jones for automation support; Paul Shinn, Danielle van Leer, Crystal
   McKnight, and Misha Itkin for the assistance with compound management;
   William Leister, Heather Baker, Elizabeth Fernandez, Burchelle Blackman,
   and Christopher Leclair for analytical chemistry and purification
   support; and Emma Hughes for preparing plasma samples for bioanalytical
   characterization. This research was also supported in part by National
   Institutes of Health Grants AA022057 (V.V.) and AA021724 (V.V.).
NR 32
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U1 1
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD AUG 13
PY 2015
VL 58
IS 15
BP 5967
EP 5978
DI 10.1021/acs.jmedchem.5b00577
PG 12
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CP2BY
UT WOS:000359683700020
PM 26207746
ER

PT J
AU Boateng, CA
   Bakare, OM
   Zhan, J
   Banala, AK
   Burzynski, C
   Pommier, E
   Keck, TM
   Donthamsetti, P
   Javitch, JA
   Rais, R
   Slusher, BS
   Xi, ZX
   Newman, AH
AF Boateng, Comfort A.
   Bakare, Oluyomi M.
   Zhan, Jia
   Banala, Ashwini K.
   Burzynski, Caitlin
   Pommier, Elie
   Keck, Thomas M.
   Donthamsetti, Prashant
   Javitch, Jonathan A.
   Rais, Rana
   Slusher, Barbara S.
   Xi, Zheng-Xiong
   Newman, Amy Hauck
TI High Affinity Dopamine D-3 Receptor (D3R)-Selective Antagonists
   Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout
   Mice
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID FUNCTIONALIZED LINKING CHAINS; POSITRON-EMISSION-TOMOGRAPHY; CHRONIC
   BUSPIRONE TREATMENT; COCAINE-SEEKING BEHAVIOR; ABUSE THERAPEUTIC AGENTS;
   NUCLEUS-ACCUMBENS; INTRAVENOUS HEROIN; PARTIAL AGONISTS; BRAIN REWARD;
   ADDICTION
AB The dopamine D-3 receptor (D3R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D3R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailability, metabolic instability, and/or predicted toxicity have impeded success in translating these drug candidates to clinical use. Herein, we report a series of D3R-selective 4-phenylpiperazines with improved metabolic stability. A subset of these compounds was evaluated for D3R functional efficacy and off-target binding at selected 5-HT receptor subtypes, where significant overlap in SAR with D3R has been observed. Several high affinity D3R antagonists, including compounds 16 (K-i = 0.12 nM) and 32 (K-i = 0.35 nM), showed improved metabolic stability compared to the parent compound, PG648 (6). Notably, 16 and the classic D3R antagonist SB277011A (2) were effective in reducing selfadministration of heroin in wild-type but not D3R knockout mice.
C1 [Boateng, Comfort A.; Bakare, Oluyomi M.; Zhan, Jia; Banala, Ashwini K.; Burzynski, Caitlin; Pommier, Elie; Keck, Thomas M.; Xi, Zheng-Xiong; Newman, Amy Hauck] NIDA, Mol Targets & Medicat Discovery Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
   [Keck, Thomas M.] Rowan Univ, Sch Biomed Sci & Hlth Profess, Dept Biomed & Translat Sci, Dept Chem & Biochem,Coll Sci & Math, Glassboro, NJ 08028 USA.
   [Rais, Rana; Slusher, Barbara S.] Johns Hopkins Univ, Sch Med, Brain Sci Inst, Dept Neurol, Baltimore, MD 21205 USA.
   [Donthamsetti, Prashant; Javitch, Jonathan A.] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA.
   [Donthamsetti, Prashant; Javitch, Jonathan A.] Columbia Univ Coll Phys & Surg, Dept Pharmacol, New York, NY 10032 USA.
   [Donthamsetti, Prashant; Javitch, Jonathan A.] New York State Psychiat Inst & Hosp, Div Mol Therapeut, New York, NY 10032 USA.
RP Newman, AH (reprint author), NIDA, Mol Targets & Medicat Discovery Branch, Intramural Res Program, NIH, 333 Cassell Dr, Baltimore, MD 21224 USA.
EM anewrnan@intra.nida.nih.gov
RI Keck, Thomas/G-9798-2012; 
OI Keck, Thomas/0000-0003-1845-9373; Boateng, Comfort/0000-0003-1907-431X
FU National Institute on Drug Abuse-Intramural Research Program; Johns
   Hopkins Brain Science Institute [DA022413, MH54137]
FX Support for this research was provided by the National Institute on Drug
   Abuse-Intramural Research Program C.A.B., J.Z., A.K.B., C.B., E.P.,
   T.M.K., Z.-X.X., and A.H.N.) and the Johns Hopkins Brain Science
   Institute (R.R. and B.S.), DA022413, and MH54137 (P.D. and J.A.J.). We
   acknowledge Alessandro Bonifazi and Catherine Schweppe for their
   technical assistance with the binding assays and Rachel Slack for a
   critical reading of an earlier version of this manuscript.
NR 70
TC 7
Z9 7
U1 3
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD AUG 13
PY 2015
VL 58
IS 15
BP 6195
EP 6213
DI 10.1021/acs.jmedchem.5b00776
PG 19
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CP2BY
UT WOS:000359683700034
PM 26203768
ER

PT J
AU Belfort, MA
   Saade, GR
   Thom, E
   Blackwell, SC
   Reddy, UM
   Thorp, JM
   Tita, ATN
   Miller, RS
   Peaceman, AM
   McKenna, DS
   Chien, EKS
   Rouse, DJ
   Gibbs, RS
   El-Sayed, YY
   Sorokin, Y
   Caritis, SN
   VanDorsten, JP
AF Belfort, Michael A.
   Saade, George R.
   Thom, Elizabeth
   Blackwell, Sean C.
   Reddy, Uma M.
   Thorp, John M. J.
   Tita, Alan T. N.
   Miller, Russell S.
   Peaceman, Alan M.
   McKenna, David S.
   Chien, Edward K. S.
   Rouse, Dwight J.
   Gibbs, Ronald S.
   El-Sayed, Yasser Y.
   Sorokin, Yoram
   Caritis, Steve N.
   VanDorsten, J. Peter
CA Eunice Kennedy Shriver Natl Inst C
TI A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID GRADED HYPOXIA; ELECTROCARDIOGRAM; CARDIOTOCOGRAPHY; ENCEPHALOPATHY;
   WOMEN; SHEEP
AB BACKGROUND
   It is unclear whether using fetal electrocardiographic (ECG) ST-segment analysis as an adjunct to conventional intrapartum electronic fetal heart-rate monitoring modifies intrapartum and neonatal outcomes.
   METHODS
   We performed a multicenter trial in which women with a singleton fetus who were attempting vaginal delivery at more than 36 weeks of gestation and who had cervical dilation of 2 to 7 cm were randomly assigned to "open" or "masked" monitoring with fetal ST-segment analysis. The masked system functioned as a normal fetal heart-rate monitor. The open system displayed additional information for use when uncertain fetal heart-rate patterns were detected. The primary outcome was a composite of intrapartum fetal death, neonatal death, an Apgar score of 3 or less at 5 minutes, neonatal seizure, an umbilical-artery blood pH of 7.05 or less with a base deficit of 12 mmol per liter or more, intubation for ventilation at delivery, or neonatal encephalopathy.
   RESULTS
   A total of 11,108 patients underwent randomization; 5532 were assigned to the open group, and 5576 to the masked group. The primary outcome occurred in 52 fetuses or neonates of women in the open group (0.9%) and 40 fetuses or neonates of women in the masked group (0.7%) (relative risk, 1.31; 95% confidence interval, 0.87 to 1.98; P = 0.20). Among the individual components of the primary outcome, only the frequency of a 5-minute Apgar score of 3 or less differed significantly between neonates of women in the open group and those in the masked group (0.3% vs. 0.1%, P = 0.02). There were no significant between-group differences in the rate of cesarean delivery (16.9% and 16.2%, respectively; P = 0.30) or any operative delivery (22.8% and 22.0%, respectively; P = 0.31). Adverse events were rare and occurred with similar frequency in the two groups.
   CONCLUSIONS
   Fetal ECG ST-segment analysis used as an adjunct to conventional intrapartum electronic fetal heart-rate monitoring did not improve perinatal outcomes or decrease operative-delivery rates. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and Neoventa Medical; ClinicalTrials.gov number, NCT01131260.)
C1 [Belfort, Michael A.] Med Univ S Carolina, Charleston, SC 29425 USA.
   [Saade, George R.] Univ Texas Med Branch, Galveston, TX 77555 USA.
   [Thom, Elizabeth] George Washington Univ, Ctr Biostat, Washington, DC USA.
   [Blackwell, Sean C.] Univ Texas Hlth Sci Ctr Houston, Childrens Mem Hermann Hosp, Houston, TX 77030 USA.
   [Reddy, Uma M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD 20892 USA.
   [Thorp, John M. J.] Univ N Carolina, Chapel Hill, NC USA.
   [Tita, Alan T. N.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Miller, Russell S.] Columbia Univ, New York, NY USA.
   [Peaceman, Alan M.] Northwestern Univ, Chicago, IL 60611 USA.
   [McKenna, David S.] Ohio State Univ, Columbus, OH 43210 USA.
   [Chien, Edward K. S.] Case Western Reserve Univ, Metrohlth Med Ctr, Cleveland, OH 44106 USA.
   [Rouse, Dwight J.] Brown Univ, Providence, RI 02912 USA.
   [Gibbs, Ronald S.] Univ Colorado, Sch Med, Aurora, CO USA.
   [El-Sayed, Yasser Y.] Stanford Univ, Stanford, CA 94305 USA.
   [Sorokin, Yoram] Wayne State Univ, Detroit, MI USA.
   [Caritis, Steve N.] Univ Pittsburgh, Pittsburgh, PA USA.
   [VanDorsten, J. Peter] Med Univ S Carolina, Charleston, SC USA.
RP Belfort, MA (reprint author), Med Univ S Carolina, Charleston, SC 29425 USA.
EM belfort@bcm.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development; Neoventa Medical
FX Funded by the Eunice Kennedy Shriver National Institute of Child Health
   and Human Development and Neoventa Medical; ClinicalTrials.gov number,
   NCT01131260.
NR 24
TC 23
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U1 1
U2 7
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD AUG 13
PY 2015
VL 373
IS 7
BP 632
EP 641
DI 10.1056/NEJMoa1500600
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CP2LE
UT WOS:000359707700008
PM 26267623
ER

PT J
AU Kang, SY
   Im, CH
   Shim, M
   Nahab, FB
   Park, J
   Kim, DW
   Kakareka, J
   Miletta, N
   Hallett, M
AF Kang, Suk Yun
   Im, Chang-Hwan
   Shim, Miseon
   Nahab, Fatta B.
   Park, Jihye
   Kim, Do-Won
   Kakareka, John
   Miletta, Nathanial
   Hallett, Mark
TI Brain Networks Responsible for Sense of Agency: An EEG Study
SO PLOS ONE
LA English
DT Article
ID ALPHA-BAND OSCILLATIONS; NEURONAL SYNCHRONIZATION; SPATIAL ATTENTION;
   CORTICAL NETWORKS; OCCIPITAL CORTEX; TOP-DOWN; SELF; PERFORMANCE;
   MOVEMENT; ELECTROENCEPHALOGRAPHY
AB Background
   Self-agency (SA) is a person's feeling that his action was generated by himself. The neural substrates of SA have been investigated in many neuroimaging studies, but the functional connectivity of identified regions has rarely been investigated. The goal of this study is to investigate the neural network related to SA.
   Methods
   SA of hand movements was modulated with virtual reality. We examined the cortical network relating to SA modulation with electroencephalography (EEG) power spectrum and phase coherence of alpha, beta, and gamma frequency bands in 16 right-handed, healthy volunteers.
   Results
   In the alpha band, significant relative power changes and phase coherence of alpha band were associated with SA modulation. The relative power decrease over the central, bilateral parietal, and right temporal regions (C4, Pz, P3, P4, T6) became larger as participants more effectively controlled the virtual hand movements. The phase coherence of the alpha band within frontal areas (F7-FP2, F7-Fz) was directly related to changes in SA. The functional connectivity was lower as the participants felt that they could control their virtual hand. In the other frequency bands, significant phase coherences were observed in the frontal (or central) to parietal, temporal, and occipital regions during SA modulation (Fz-O1, F3-O1, Cz-O1, C3-T4L in beta band; FP1-T6, FP1-O2, F7-T4L, F8-Cz in gamma band).
   Conclusions
   Our study suggests that alpha band activity may be the main neural oscillation of SA, which suggests that the neural network within the anterior frontal area may be important in the generation of SA.
C1 [Kang, Suk Yun] Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Dept Neurol, Hwaseong Si, Gyeonggi Do, South Korea.
   [Kang, Suk Yun; Nahab, Fatta B.; Miletta, Nathanial; Hallett, Mark] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA.
   [Im, Chang-Hwan; Shim, Miseon; Kim, Do-Won] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea.
   [Nahab, Fatta B.] Univ Calif San Diego, Dept Neurol, San Diego, CA 92103 USA.
   [Park, Jihye; Kim, Do-Won] Yonsei Univ, Dept Biomed Engn, Wonju, Kangwon Do, South Korea.
   [Kakareka, John] NIH, Signal Proc & Instrumentat Sect, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
RP Hallett, M (reprint author), NINDS, Human Motor Control Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM hallettm@ninds.nih.gov
OI Kakareka, John/0000-0003-0072-0035
FU National Institute of Neurological Disorders and Stroke (NINDS) at the
   NIH; Public Welfare and Safety Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future
   Planning [NRF-2011-0027859]
FX This work was supported by the intramural research program of the
   National Institute of Neurological Disorders and Stroke (NINDS) at the
   NIH and in part by the Public Welfare and Safety Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Science, ICT & Future Planning (No. NRF-2011-0027859).
NR 66
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U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 13
PY 2015
VL 10
IS 8
AR e0135261
DI 10.1371/journal.pone.0135261
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9JX
UT WOS:000359492800046
PM 26270552
ER

PT J
AU Mushemi-Blake, S
   Melikian, N
   Drasar, E
   Bhan, A
   Lunt, A
   Desai, SR
   Greenough, A
   Monaghan, MJ
   Thein, SL
   Shah, AM
AF Mushemi-Blake, Sitali
   Melikian, Narbeh
   Drasar, Emma
   Bhan, Amit
   Lunt, Alan
   Desai, Sujal R.
   Greenough, Anne
   Monaghan, Mark J.
   Thein, Swee Lay
   Shah, Ajay M.
TI Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly
   by a High-Output State Rather Than Elevated Pulmonary Vascular
   Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study
SO PLOS ONE
LA English
DT Article
ID EXERCISE CAPACITY; OF-CARDIOLOGY; UNITED-STATES; TASK-FORCE;
   HYPERTENSION; ANEMIA; HEART; RECOMMENDATIONS; ASSOCIATION; SOCIETY
AB Aims
   Patients with sickle cell disease have significant morbidity and mortality. Pulmonary hypertension is suggested to be an important contributor but its nature and severity in these patients and how best to non-invasively assess it are controversial. We hypothesised that a high-output state rather than primary pulmonary vascular pathology may be the major abnormality in sickle cell disease. This study aimed to evaluate the characteristics and severity of pulmonary hypertension in patients with sickle cell disease using detailed echocardiography.
   Methods and Results
   We undertook a prospective study in 122 consecutive stable outpatients with sickle cell disease and 30 age, gender and ethnicity-matched healthy controls. Echocardiographic evaluation included 3D ventricular volumes, sphericity, tissue Doppler, and non-invasive estimation of pulmonary vascular resistance. 36% of patients had a tricuspid regurgitant velocity >= 2.5 m.s(-1) but only 2% had elevated pulmonary vascular resistance and the prevalence of right ventricular dysfunction was very low. Patients with raised tricuspid regurgitant velocity had significantly elevated biventricular volumes and globular left ventricular remodelling, related primarily to anaemia. In a subgroup of patients who underwent cardiac catheterization, invasive pulmonary haemodynamics confirmed the echocardiographic findings.
   Conclusions
   Elevated cardiac output and left ventricular volume overload secondary to chronic anaemia may be the dominant factor responsible for abnormal cardiopulmonary haemodynamics in patients with sickle cell disease. 3D echocardiography with non-invasive estimation of pulmonary vascular resistance represents a valuable approach for initial evaluation of cardiopulmonary haemodynamics in sickle cell disease.
C1 [Mushemi-Blake, Sitali; Melikian, Narbeh; Monaghan, Mark J.; Shah, Ajay M.] Kings Coll London, British Heart Fdn Ctr, Div Cardiovasc, London WC2R 2LS, England.
   [Mushemi-Blake, Sitali; Melikian, Narbeh; Bhan, Amit; Monaghan, Mark J.; Shah, Ajay M.] Kings Coll Hosp London, Dept Cardiol, London, England.
   [Drasar, Emma; Thein, Swee Lay] Kings Coll Hosp London, Dept Haematol Med, London, England.
   [Lunt, Alan; Greenough, Anne] Kings Coll Hosp London, Dept Paediat, London, England.
   [Desai, Sujal R.] Kings Coll Hosp London, Dept Radiol, London, England.
   [Thein, Swee Lay] Natl Inst Heart Lung & Blood Dis, NIH, Sickle Cell Branch, Bethesda, MD USA.
RP Shah, AM (reprint author), Kings Coll London, British Heart Fdn Ctr, Div Cardiovasc, London WC2R 2LS, England.
EM ajay.shah@kcl.ac.uk
OI Shah, Ajay/0000-0002-6547-0631
FU Department of Health via a National Institute for Health Research (NIHR)
   Biomedical Research Centre; British Heart Foundation [RE/13/2/30182]
FX SMB was funded by the Department of Health via a National Institute for
   Health Research (NIHR) Biomedical Research Centre award to Guy's & St
   Thomas' NHS Foundation Trust in partnership with King's College London
   and King's College Hospital NHS Foundation Trust. AMS is supported by
   research grants from the British Heart Foundation (RE/13/2/30182). The
   funders had no role in study design, data collection, decision to
   publish, or preparation off the manuscript.
NR 25
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Z9 3
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 13
PY 2015
VL 10
IS 8
AR e0135472
DI 10.1371/journal.pone.0135472
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9JX
UT WOS:000359492800080
PM 26270484
ER

PT J
AU Hauser, W
   Ablin, J
   Fitzcharles, MA
   Littlejohn, G
   Luciano, JV
   Usui, C
   Walitt, B
AF Haeuser, Winfried
   Ablin, Jacob
   Fitzcharles, Mary-Ann
   Littlejohn, Geoffrey
   Luciano, Juan V.
   Usui, Chie
   Walitt, Brian
TI Fibromyalgia
SO NATURE REVIEWS DISEASE PRIMERS
LA English
DT Article
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; PRELIMINARY
   DIAGNOSTIC-CRITERIA; INTRINSIC BRAIN CONNECTIVITY; FUNCTIONAL SOMATIC
   SYNDROMES; CHRONIC-FATIGUE-SYNDROME; CHRONIC WIDESPREAD PAIN;
   HEART-RATE-VARIABILITY; GENERAL-POPULATION; CEREBROSPINAL-FLUID
AB Fibromyalgia is a common illness characterized by chronic widespread pain, sleep problems (including unrefreshing sleep), physical exhaustion and cognitive difficulties. The definition, pathogenesis and treatment are controversial, and some even contest the existence of this disorder. In 1990, the American College of Rheumatology (ACR) defined classification criteria that required multiple tender points (areas of tenderness occurring in muscles and muscle-tendon junctions) and chronic widespread pain. In 2010, the ACR preliminary diagnostic criteria excluded tender points, allowed less extensive pain and placed reliance on patient-reported somatic symptoms and cognitive difficulties. Fibromyalgia occurs in all populations worldwide, and symptom prevalence ranges between 2% and 4% in the general population. The prevalence of people who are actually diagnosed with fibromyalgia ('administrative prevalence') is much lower. A model of fibromyalgia pathogenesis has been suggested in which biological and psychosocial variables interact to influence the predisposition, triggering and aggravation of a chronic disease, but the details are unclear. Diagnosis requires the history of a typical cluster of symptoms and the exclusion of a somatic disease that sufficiently explains the symptoms by medical examination. Current evidence-based guidelines emphasize the value of multimodal treatments, which encompass both non-pharmacological and selected pharmacological treatments tailored to individual symptoms, including pain, fatigue, sleep problems and mood problems. For an illustrated summary of this Primer, visit: http://go.nature.com/LIBdDX
C1 [Haeuser, Winfried] Klinikum Saarbrucken, Dept Internal Med 1, Winterberg 1, D-66119 Saarbrucken, Germany.
   [Haeuser, Winfried] Tech Univ Munich, Dept Psychosomat Med & Psychotherapy, D-81675 Munich, Germany.
   [Ablin, Jacob] Tel Aviv Univ, Inst Rheumatol, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
   [Ablin, Jacob] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Fitzcharles, Mary-Ann] McGill Univ, Ctr Hlth, Montreal, PQ, Canada.
   [Littlejohn, Geoffrey] Monash Hlth, Dept Rheumatol, Clayton, Vic, Australia.
   [Littlejohn, Geoffrey] Monash Hlth, Dept Med, Clayton, Vic, Australia.
   [Littlejohn, Geoffrey] Monash Univ, Clayton, Vic, Australia.
   [Luciano, Juan V.] Parc Sanitari St Joan de Deu, Teaching Res & Innovat Unit, Barcelona, Spain.
   [Usui, Chie] Juntendo Univ, Dept Psychiat, Sch Med, Tokyo, Japan.
   [Walitt, Brian] NIH, Natl Ctr Complementary & Integrat Hlth, Bethesda, MD 20892 USA.
   [Walitt, Brian] NINR, NIH, Bethesda, MD 20892 USA.
RP Hauser, W (reprint author), Klinikum Saarbrucken, Dept Internal Med 1, Winterberg 1, D-66119 Saarbrucken, Germany.
EM whaeuser@klinikum-saarbruecken.de
FU Intramural Research Program of the US NIH, National Center for
   Complementary and Integrative Health (NCCIH); National Institute of
   Nursing Research (NINR); Institute of Health Carlos III (ISCIII, Madrid,
   Spain) [CP14/00087]
FX D. Clauw provided useful discussions and contributions to the writing
   and editing process but chose not to be credited with authorship. This
   manuscript was supported (in part) by the Intramural Research Program of
   the US NIH, National Center for Complementary and Integrative Health
   (NCCIH) and National Institute of Nursing Research (NINR). J.V.L. has a
   Miguel Servet research contract awarded by the Institute of Health
   Carlos III (CP14/00087; ISCIII, Madrid, Spain).
NR 181
TC 12
Z9 12
U1 4
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2056-676X
J9 NAT REV DIS PRIMERS
JI Nat. Rev. Dis. Primers
PD AUG 13
PY 2015
VL 1
AR 15022
DI 10.1038/nrdp.2015.22
PG 16
WC Medicine, General & Internal
SC General & Internal Medicine
GA DT2LM
UT WOS:000381311800001
PM 27189527
ER

PT J
AU Flores, R
   Shi, JX
   Yu, GQ
   Ma, B
   Ravel, J
   Goedert, JJ
   Sinha, R
AF Flores, Roberto
   Shi, Jianxin
   Yu, Guoqin
   Ma, Bing
   Ravel, Jacques
   Goedert, James J.
   Sinha, Rashmi
TI Collection media and delayed freezing effects on microbial composition
   of human stool
SO MICROBIOME
LA English
DT Article
ID HUMAN GUT MICROBIOME; STORAGE-CONDITIONS; BACTERIAL COMMUNITIES;
   COLORECTAL-CANCER; DISEASE; HEALTH; RNA; SAMPLES; FECES; TUMOR
AB Background: Different bacteria in stool have markedly varied growth and survival when stored at ambient temperature. It is paramount to develop optimal biostabilization of stool samples during collection and assess long-term storage for clinical specimens and epidemiological microbiome studies. We evaluated the effect of collection media and delayed freezing up to 7 days on microbial composition. Ten participants collected triplicate stool samples each into no media as well as RNAlater (R) with and without kanamycin or ciprofloxacin. For each set of conditions, triplicate samples were frozen on dry ice immediately (time = 0) or frozen at -80 degrees C after 3-days and 7-days incubation at 25 degrees C. Microbiota metrics were estimated from Illumina MiSeq sequences of 16S rRNA gene fragments (V3-V4 region). Intraclass correlation coefficients (ICC) across triplicates, collection media, and incubation time were estimated for taxonomy and alpha and beta diversity metrics.
   Results: RNAlater (R) alone yielded the highest ICCs for diversity metrics at time = 0 [ICC median 0.935 (range 0.89-0.97)], but ICCs varied greatly (range 0.44-1.0) for taxa with relative abundances <1 %. The 3- and 7-day freezing delays were generally associated with stable beta diversity for all three media conditions. Freezing delay caused increased variance for Shannon index (median ICC 0.77) and especially for observed species abundance (median ICC 0.47). Variance in observed species abundance and in phylogenetic distance whole tree was similarly increased with a 7-day delay. Antibiotics did not mitigate variance. No media had inferior ICCs at time 0 and differed markedly from any media in microbiome composition (e.g., P = 0.01 for relative abundance of Bacteroidetes).
   Conclusion: Bacterial community composition was stable for 7 days at room temperature in RNAlater (R) alone. RNAlater (R) provides some stability for beta diversity analyses, but analyses of rare taxa will be inaccurate if specimens are not frozen immediately. RNAlater (R) could be used as collection media with minimal change in the microbiota composition.
C1 [Flores, Roberto] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA.
   [Shi, Jianxin] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
   [Yu, Guoqin; Goedert, James J.] NCI, Infect & Immunoepidemiol Branch, DCEG, NIH, Bethesda, MD 20892 USA.
   [Ma, Bing; Ravel, Jacques] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
   [Sinha, Rashmi] NCI, Nutr Epidemiol Branch, DCEG, NIH, Bethesda, MD 20892 USA.
RP Flores, R (reprint author), NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH, 9609 Med Ctr Dr RM5E554 MSC9788, Bethesda, MD 20892 USA.
EM floresr2@mail.nih.gov
OI Ravel, Jacques/0000-0002-0851-2233
FU Intramural Research Program, National Cancer Institute, National
   Institutes of Health
FX Supported by the Intramural Research Program, National Cancer Institute,
   National Institutes of Health.
NR 42
TC 14
Z9 14
U1 2
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2049-2618
J9 MICROBIOME
JI Microbiome
PD AUG 12
PY 2015
VL 3
AR 33
DI 10.1186/s40168-015-0092-7
PG 11
WC Microbiology
SC Microbiology
GA CU0WB
UT WOS:000363238500001
PM 26269741
ER

PT J
AU Murphy, AP
AF Murphy, Aidan P.
TI Mapping Functional Topography in the Macaque Ventral Visual Pathway
SO JOURNAL OF NEUROSCIENCE
LA English
DT Editorial Material
ID INFERIOR TEMPORAL CORTEX; 3D SHAPE; DISPARITY; FACES; DEPTH; AREAS
C1 [Murphy, Aidan P.] NIMH, Sect Cognit Neurophysiol & Imaging, Neuropsychol Lab, Bethesda, MD 20832 USA.
RP Murphy, AP (reprint author), Room B1C60,49 Convent Dr, Bethesda, MD 20832 USA.
EM murphyap@mail.nih.gov
NR 14
TC 0
Z9 0
U1 0
U2 10
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 12
PY 2015
VL 35
IS 32
BP 11171
EP 11173
DI 10.1523/JNEUROSCI.2108-15.2015
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA CR2DD
UT WOS:000361134300001
PM 26269627
ER

PT J
AU Doona, CJ
   Feeherry, FE
   Kustin, K
   Olinger, GG
   Setlow, P
   Malkin, AJ
   Leighton, T
AF Doona, Christopher J.
   Feeherry, Florence E.
   Kustin, Kenneth
   Olinger, Gene G.
   Setlow, Peter
   Malkin, Alexander J.
   Leighton, Terrance
TI Fighting Ebola with novel spore decontamination technologies for the
   military
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Ebola; decontamination technologies; spores; chrloine dioxide; military
   medicine
ID BACILLUS-SUBTILIS SPORES; DRINKING-WATER TREATMENT; CHLORINE DIOXIDE
   GAS; BACTERIAL-SPORES; HIGH-PRESSURE; DIPICOLINIC ACID;
   CLOSTRIDIUM-PERFRINGENS; ENDOSPORE INACTIVATION; STRUCTURAL DYNAMICS;
   CORTEX HYDROLYSIS
AB Recently, global public health organizations such as Doctors without Borders (MSF), the World Health Organization (WHO), Public Health Canada, National Institutes of Health (NIH), and the U.S. government developed and deployed Field Decontamination Kits (FDKs), a novel, lightweight, compact, reusable decontamination technology to sterilize Ebola-contaminated medical devices at remote clinical sites lacking infrastructure in crisis-stricken regions of West Africa (medical waste materials are placed in bags and burned). The basis for effectuating sterilization with FDKs is chlorine dioxide (CIO2) produced from a patented invention developed by researchers at the US Army Natick Soldier RD&E Center (NSRDEC) and commercialized as a dry mixed-chemical for bacterial spore decontamination. In fact, the NSRDEC research scientists developed an ensemble of ClO2 technologies designed for different applications in decontaminating fresh produce; food contact and handling surfaces; personal protective equipment; textiles used in clothing, uniforms, tents, and shelters; graywater recycling; airplanes; surgical instruments; and hard surfaces in latrines, laundries, and deployable medical facilities. These examples demonstrate the far-reaching impact, adaptability, and versatility of these innovative technologies. We present herein the unique attributes of NSRDEC's novel decontamination technologies and a Case Study of the development of FDKs that were deployed in West Africa by international public health organizations to sterilize Ebola-contaminated medical equipment. FDKs use bacterial spores as indicators of sterility. We review the properties and structures of spores and the mechanisms of bacterial spore inactivation by ClO2. We also review mechanisms of bacterial spore inactivation by novel, emerging, and established non-thermal technologies for food preservation, such as high pressure processing, irradiation, cold plasma, and chemical sanitizers, using an array of Bacillus subtilis mutants to probe mechanisms of spore germination and inactivation. We employ techniques of high-resolution atomic force microscopy and phase contrast microscopy to examine the effects of 'y-irradiation on bacterial spores of Bacillus anthracis, Bacillus thuringiensis, and Bacillus atrophaeus spp. and of ClO2 on B. subtilis spores, and present in detail assays using spore bio-indicators to ensure sterility when decontaminating with ClO2.
C1 [Doona, Christopher J.; Feeherry, Florence E.] US Army Natick, Soldier RD&E Ctr, Warfighter Directorate, Natick, MA 01760 USA.
   [Kustin, Kenneth] Brandeis Univ, Dept Chem, Waltham, MA 02254 USA.
   [Olinger, Gene G.] NIAID, Integrated Res Facil, Div Clin Res, Ft Detrick, MD USA.
   [Setlow, Peter] Univ Connecticut, Ctr Hlth, Dept Mol Biol & Biophys, Farmington, CT USA.
   [Malkin, Alexander J.] Lawrence Livermore Natl Lab, Biosci & Biotechnol Div, Phys & Life Sci Directorate, Livermore, CA USA.
   [Leighton, Terrance] Univ Calif San Francisco Benioff, Childrens Hosp, Oakland Res Inst, Oakland, CA USA.
RP Doona, CJ (reprint author), US Army Natick, Soldier RD&E Ctr, Warfighter Directorate, Kansas St, Natick, MA 01760 USA.
EM christopher.j.doona.civ@mail.mil
FU Army Research Office; Defense Threat Reduction Agency; NIH; U.S.
   Department of Energy by Lawrence Livermore National Laboratory
   [DE-AC52-07NA27344]; Federal Bureau of Investigation; Lawrence Livermore
   National Laboratory through Laboratory Directed Research and Development
   [04-ERD-002]; Defense Advanced Research Projects Agency (DARPA)
FX Work carried out in the Set low laboratory on spore resistance and
   killing has received generous support over many years from the Army
   Research Office, the Defense Threat Reduction Agency, and the NIH.; The
   AFM work in the Malkin laboratory was performed under the auspices of
   the U.S. Department of Energy by Lawrence Livermore National Laboratory
   under Contract DE-AC52-07NA27344 and supported by a grant from the
   Federal Bureau of Investigation and by Lawrence Livermore National
   Laboratory through Laboratory Directed Research and Development Grant
   04-ERD-002. The authors are grateful to Marco Plomp for his critical
   contributions in the AFM characterization and data analysis.; Work in
   the Leighton laboratory was funded by The Defense Advanced Research
   Projects Agency (DARPA). We acknowledge with pleasure and gratitude the
   contributions of Katie Wheeler and Gordon Eggum to the study of
   ClO<INF>2</INF> bioindicators.
NR 92
TC 1
Z9 1
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD AUG 12
PY 2015
VL 6
AR 663
DI 10.3389/fmicb.2015.00663
PG 25
WC Microbiology
SC Microbiology
GA CP3XF
UT WOS:000359815400001
PM 26322021
ER

PT J
AU Garaicoechea, L
   Aguilar, A
   Parra, GI
   Bok, M
   Sosnovtsev, SV
   Canziani, G
   Green, KY
   Bok, K
   Parreno, V
AF Garaicoechea, Lorena
   Aguilar, Andrea
   Parra, Gabriel I.
   Bok, Marina
   Sosnovtsev, Stanislav V.
   Canziani, Gabriela
   Green, Kim Y.
   Bok, Karin
   Parreno, Viviana
TI Llama Nanoantibodies with Therapeutic Potential against Human Norovirus
   Diarrhea
SO PLOS ONE
LA English
DT Article
ID VIRUS-LIKE PARTICLES; BLOOD GROUP ANTIGENS; BIOSPECIFIC INTERACTION
   ANALYSIS; REACTIVE MONOCLONAL-ANTIBODY; RESPIRATORY SYNCYTIAL VIRUS;
   RECOMBINANT CAPSID PROTEIN; ROTAVIRUS-INDUCED DIARRHEA; SURFACE-PLASMON
   RESONANCE; SINGLE-DOMAIN ANTIBODIES; NORWALK VIRUS
AB Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages over conventional antibodies. The aim of this study was to generate recombinant monoclonal VHH specific for the two major norovirus (NoV) genogroups (GI and GII) in order to investigate their potential as immunotherapy for the treatment of NoV diarrhea. To accomplish this objective, two llamas were immunized with either GI.1 (Norwalk-1968) or GII. 4 (MD2004) VLPs. After immunization, peripheral blood lymphocytes were collected and used to generate two VHH libraries. Using phage display technology, 10 VHH clones specific for GI.1, and 8 specific for GII.4 were selected for further characterization. All VHH recognized conformational epitopes in the P domain of the immunizing VP1 capsid protein, with the exception of one GII. 4 VHH that recognized a linear P domain epitope. The GI.1 VHHs were highly specific for the immunizing GI.1 genotype, with only one VHH cross-reacting with GI. 3 genotype. The GII.4 VHHs reacted with the immunizing GII.4 strain and showed a varying reactivity profile among different GII genotypes. One VHH specific for GI.1 and three specific for GII.4 could block the binding of homologous VLPs to synthetic HBGA carbohydrates, saliva, and pig gastric mucin, and in addition, could inhibit the hemagglutination of red blood cells by homologous VLPs. The ability of Nov-specific VHHs to perform well in these surrogate neutralization assays supports their further development as immunotherapy for NoV treatment and immunoprophylaxis.
C1 [Garaicoechea, Lorena; Aguilar, Andrea; Bok, Marina; Parreno, Viviana] INTA, Inst Virol, Buenos Aires, DF, Argentina.
   [Parra, Gabriel I.; Sosnovtsev, Stanislav V.; Green, Kim Y.; Bok, Karin] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
   [Canziani, Gabriela] Inst Leloir, Buenos Aires, DF, Argentina.
RP Parreno, V (reprint author), INTA, Inst Virol, Buenos Aires, DF, Argentina.
EM parreno.viviana@inta.gob.ar
OI Parra, Gabriel/0000-0002-1102-4740
FU FONARSEC department of the Argentinean Ministry of Science [INTA BIO AF
   03]; INTA specific project [PNBIO-1131033]; Division of Intramural
   Research in NIAID, NIH, USA; INTA; CONICET
FX This project was financially supported by the FONARSEC department of the
   Argentinean Ministry of Science, with a Grant on Fuctional Food, "INTA
   BIO AF 03" (VP)
   (http://www.agencia.mincyt.gob.ar/frontend/agencia/fondo/fonarsec), the
   INTA specific project No PNBIO-1131033 (VP) (www.inta.gob.ar), and the
   Division of Intramural Research in NIAID, NIH, USA (KG) (www.nih.gov).
   The salaries of VP and LG were supported by INTA. Salaries of AA and MB
   were supported by CONICET. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 95
TC 4
Z9 4
U1 2
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2015
VL 10
IS 8
AR e0133665
DI 10.1371/journal.pone.0133665
PG 33
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9JT
UT WOS:000359492300021
PM 26267898
ER

PT J
AU Huang, YM
   Merkatz, RB
   Hillier, SL
   Roberts, K
   Blithe, DL
   Sitruk-Ware, R
   Creinin, MD
AF Huang, Yongmei
   Merkatz, Ruth B.
   Hillier, Sharon L.
   Roberts, Kevin
   Blithe, Diana L.
   Sitruk-Ware, Regine
   Creinin, Mitchell D.
TI Effects of a One Year Reusable Contraceptive Vaginal Ring on Vaginal
   Microflora and the Risk of Vaginal Infection: An Open-Label Prospective
   Evaluation
SO PLOS ONE
LA English
DT Article
ID BACTERIAL VAGINOSIS; ORAL-CONTRACEPTIVES; FLORA; ACCEPTABILITY;
   ETHINYLESTRADIOL; EFFICACY; WOMEN; TRIAL; CYCLE
AB Background
   A contraceptive vaginal ring (CVR) containing Nestorone (R) (NES) and ethinyl estradiol (EE) that is reusable for 1-year (13 cycles) is under development. This study assessed effects of this investigational CVR on the incidence of vaginal infections and change in vaginal microflora.
   Methods
   There were 120 women enrolled into a NES/EE CVR Phase III trial and a microbiology sub-study for up to 1-year of cyclic product use. Gynecological examinations were conducted at baseline, the first week of cycle 6 and last week of cycle 13 (or during early discontinuation visits). Vaginal swabs were obtained for wet mount microscopy, Gram stain and culture. The CVR was removed from the vagina at the last study visit and cultured. Semi-quantitative cultures for Lactobacillus, Gardnerella vaginalis, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, anaerobic gram negative rods (GNRs), Candida albicans and other yeasts were performed on vaginal and CVR samples. Vaginal infections were documented throughout the study.
   Results
   Over 1-year of use, 3.3% of subjects were clinically diagnosed with bacterial vaginosis, 15.0% with vulvovaginal candidiasis, and 0.8% with trichomoniasis. The detection rate of these three infections did not change significantly from baseline to either Cycle 6 or 13. Nugent scores remained stable. H2O2-positive Lactobacillus dominated vaginal flora with a non-significant prevalence increase from 76.7% at baseline to 82.7% at cycle 6 and 90.2% at cycle 13, and a median concentration of 10(7) colony forming units (cfu) per gram. Although anaerobic GNRs prevalence increased significantly, the median concentration decreased slightly (10(4) to 10(3) cfu per gram). There were no significant changes in frequency or concentrations of other pathogens. High levels of agreement between vaginal and ring surface microbiota were observed.
   Conclusion
   Sustained use of the NES/EE CVR did not increase the risk of vaginal infection and was not disruptive to the vaginal ecosystem.
C1 [Huang, Yongmei; Merkatz, Ruth B.; Roberts, Kevin; Sitruk-Ware, Regine] Populat Council, Ctr Biomed Res, New York, NY 10021 USA.
   [Hillier, Sharon L.] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA.
   [Hillier, Sharon L.] Magee Womens Res Inst, Pittsburgh, PA USA.
   [Blithe, Diana L.] NICHHD, Contracept Discovery & Dev Branch, Bethesda, MD 20892 USA.
   [Creinin, Mitchell D.] Univ Calif Davis, Dept Obstet & Gynecol, Sacramento, CA 95817 USA.
RP Merkatz, RB (reprint author), Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA.
EM RMerkatz@popcouncil.org
FU National Institute of Child Health and Human Development of the National
   Institutes of Health (NICHD) [HHSN27500403372]; US Aid for International
   Development (USAID) [GPO-A-00-04-00019]; Population Council
FX This study was supported by the National Institute of Child Health and
   Human Development of the National Institutes of Health (NICHD, Contract
   Number: HHSN27500403372; URL-http://www.nichd.nih.gov). Diana Blithe, as
   project officer from NICHD for this study, did review the study protocol
   for contractual purposes. However, NICHD had no other role in study
   design, data collection, or analysis. Dr. Diana Blithe participated in
   the decision to publish, and the preparation of the manuscript. Drs.
   Ruth Merkatz, Regine Stiruk Ware, and Kevin Roberts were supported by US
   Aid for International Development (USAID GPO-A-00-04-00019;
   www.usaid.gov) for work associated with the conduct of this trial and
   analysis of data. USAID had no role in the design of this clinical
   trial, the conduct of the study, collection of data, or in the decision
   to publish results. Dr. Yongmei Huang was supported by the Fred H. Bixby
   fellowship program of the Population Council.
NR 37
TC 3
Z9 3
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2015
VL 10
IS 8
AR e0134460
DI 10.1371/journal.pone.0134460
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9JT
UT WOS:000359492300047
PM 26267119
ER

PT J
AU Galvani, S
   Sanson, M
   Blaho, VA
   Swendeman, SL
   Conger, H
   Dahlback, B
   Kono, M
   Proia, RL
   Smith, JD
   Hla, T
AF Galvani, Sylvain
   Sanson, Marie
   Blaho, Victoria A.
   Swendeman, Steven L.
   Conger, Heather
   Dahlback, Bjorn
   Kono, Mari
   Proia, Richard L.
   Smith, Jonathan D.
   Hla, Timothy
TI HDL-bound sphingosine 1-phosphate acts as a biased agonist for the
   endothelial cell receptor S1P(1) to limit vascular inflammation
SO SCIENCE SIGNALING
LA English
DT Article
ID NF-KAPPA-B; PROTEIN-COUPLED RECEPTOR; SPHINGOSINE-1-PHOSPHATE ANALOG;
   CARDIOVASCULAR-DISEASE; LEUKOCYTE ADHESION; DEFICIENT MICE;
   ATHEROSCLEROSIS; TRAFFICKING; ACTIVATION; FTY720
AB The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function. In investigating the role of endothelial cell S1P(1) in adult mice, we found that the endothelial S1P(1) signal was enhanced in regions of the arterial vasculature experiencing inflammation. The abundance of proinflammatory adhesion proteins, such as ICAM-1, was enhanced in mice with endothelial cell-specific deletion of S1pr1 and suppressed in mice with endothelial cell-specific overexpression of S1pr1, suggesting a protective function of S1P(1) in vascular disease. The chaperones ApoM(+)HDL (HDL) or albumin bind to sphingosine 1-phosphate (S1P) in the circulation; therefore, we tested the effects of S1P bound to each chaperone on S1P(1) signaling in cultured human umbilical vein endothelial cells (HUVECs). Exposure of HUVECs to ApoM(+)HDL-S1P, but not to albumin-S1P, promoted the formation of a cell surface S1P(1)-beta-arrestin 2 complex and attenuated the ability of the proinflammatory cytokine TNF alpha to activate NF-kappa B and increase ICAM-1 abundance. Although S1P bound to either chaperone induced MAPK activation, albumin-S1P triggered greater G(i) activation and receptor endocytosis. Endothelial cell-specific deletion of S1pr1 in the hypercholesterolemic Apoe(-/-) mouse model of atherosclerosis enhanced atherosclerotic lesion formation in the descending aorta. We propose that the ability of ApoM+ HDL to act as a biased agonist on S1P(1) inhibits vascular inflammation, which may partially explain the cardiovascular protective functions of HDL.
C1 [Galvani, Sylvain; Sanson, Marie; Blaho, Victoria A.; Swendeman, Steven L.; Hla, Timothy] Cornell Univ, Dept Pathol & Lab Med, Weill Cornell Med Coll, Ctr Vasc Biol, New York, NY 10065 USA.
   [Conger, Heather; Smith, Jonathan D.] Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44195 USA.
   [Dahlback, Bjorn] Lund Univ, Skane Univ Hosp, Dept Translat Med, S-21428 Malmo, Sweden.
   [Kono, Mari; Proia, Richard L.] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA.
RP Hla, T (reprint author), Cornell Univ, Dept Pathol & Lab Med, Weill Cornell Med Coll, Ctr Vasc Biol, New York, NY 10065 USA.
EM tih2002@med.cornell.edu
RI Hla, Timothy/G-5873-2012
OI Hla, Timothy/0000-0001-8355-4065
FU NIH [PO1-HL70694, RO1-HL89934, F32-CA142117]; Lipidomics Shared
   Resource, Hollings Cancer Center, Medical University of South Carolina
   [P30 CA138313]; Lipidomics Core in the South Carolina Lipidomics and
   Pathobiology Centers of Biomedical Research Excellence (COBRE) [P20
   RR017677]
FX This work was supported by NIH grants (PO1-HL70694 and RO1-HL89934 to
   T.H. and F32-CA142117 to V.A.B.). V.A.B. is a Leon Levy Research Fellow
   of the Weill Cornell Medical College Brain and Mind Research Institute.
   Sphingolipid measurements are supported in part by Lipidomics Shared
   Resource, Hollings Cancer Center, Medical University of South Carolina
   (P30 CA138313) and the Lipidomics Core in the South Carolina Lipidomics
   and Pathobiology Centers of Biomedical Research Excellence (COBRE) (P20
   RR017677).
NR 52
TC 27
Z9 27
U1 2
U2 12
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1945-0877
EI 1937-9145
J9 SCI SIGNAL
JI Sci. Signal.
PD AUG 11
PY 2015
VL 8
IS 389
AR ra79
DI 10.1126/scisignal.aaa2581
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CQ7TR
UT WOS:000360807900001
PM 26268607
ER

PT J
AU Kieffer-Kwon, P
   Happel, C
   Uldrick, TS
   Ramalingam, D
   Ziegelbauer, JM
AF Kieffer-Kwon, Philippe
   Happel, Christine
   Uldrick, Thomas S.
   Ramalingam, Dhivya
   Ziegelbauer, Joseph M.
TI KSHV MicroRNAs Repress Tropomyosin 1 and Increase Anchorage-Independent
   Growth and Endothelial Tube Formation
SO PLOS ONE
LA English
DT Article
ID SARCOMA-ASSOCIATED HERPESVIRUS; MOLECULAR-WEIGHT KININOGEN;
   TUMOR-SUPPRESSOR; INDUCED APOPTOSIS; GENE-EXPRESSION; ACTIN DYNAMICS;
   MESSENGER-RNA; DNA-SEQUENCES; BREAST-CANCER; CELL-LINE
AB Kaposi's sarcoma (KS) is characterized by highly vascularized spindle-cell tumors induced after infection of endothelial cells by Kaposi's sarcoma-associated herpesvirus (KSHV). In KS tumors, KSHV expresses only a few latent proteins together with 12 pre-microRNAs. Previous microarray and proteomic studies predicted that multiple splice variants of the tumor suppressor protein tropomyosin 1 (TPM1) were targets of KSHV microRNAs. Here we show that at least two microRNAs of KSHV, miR-K2 and miR-K5, repress protein levels of specific isoforms of TPM1. We identified a functional miR-K5 binding site in the 3' untranslated region (UTR) of one TPM1 isoform. Furthermore, the inhibition or loss of miR-K2 or miR-K5 restores expression of TPM1 in KSHV-infected cells. TPM1 protein levels were also repressed in KSHV-infected clinical samples compared to uninfected samples. Functionally, miR-K2 increases viability of unanchored human umbilical vein endothelial cells (HUVEC) by inhibiting anoikis (apoptosis after cell detachment), enhances tube formation of HUVECs, and enhances VEGFA expression. Taken together, KSHV miR-K2 and miR-K5 may facilitate KSHV pathogenesis.
C1 [Kieffer-Kwon, Philippe; Happel, Christine; Uldrick, Thomas S.; Ramalingam, Dhivya; Ziegelbauer, Joseph M.] NCI, NIH, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA.
RP Ziegelbauer, JM (reprint author), NCI, NIH, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA.
EM ziegelbauerjm@mail.nih.gov
OI Ziegelbauer, Joseph/0000-0001-6464-6941
FU Center for Cancer Research, National Cancer Institute, National
   Institutes of Health [1ZIABC011176-06]
FX This work was supported by the Intramural Research Program of the Center
   for Cancer Research, National Cancer Institute, National Institutes of
   Health (1ZIABC011176-06 nih.gov).
NR 66
TC 4
Z9 4
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 11
PY 2015
VL 10
IS 8
AR e0135560
DI 10.1371/journal.pone.0135560
PG 22
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO7PP
UT WOS:000359353300092
PM 26263384
ER

PT J
AU Nagy-Smith, K
   Moore, E
   Schneider, J
   Tycko, R
AF Nagy-Smith, Katelyn
   Moore, Eric
   Schneider, Joel
   Tycko, Robert
TI Molecular structure of monomorphic peptide fibrils within a kinetically
   trapped hydrogel network
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE polymorphis; amyloi; beta-hairpin; cross-beta structure; peptide design
ID BETA-AMYLOID FIBRILS; SOLID-STATE NMR; RESOLUTION 3-DIMENSIONAL
   STRUCTURE; CHEMICAL-SHIFTS; SHEET STRUCTURE; MODEL; CONSTRAINTS;
   RESONANCE; PROTEINS; DYNAMICS
AB Most, if not all, peptide- and protein-based hydrogels formed by self-assembly can be characterized as kinetically trapped 3D networks of fibrils. The propensity of disease-associated amyloid-forming peptides and proteins to assemble into polymorphic fibrils suggests that cross-beta fibrils comprising hydrogels may also be polymorphic. We use solid-state NMR to determine the molecular and supramolecular structure of MAX1, a de novo designed gel-forming peptide, in its fibrillar state. We find that MAX1 adopts a beta-hairpin conformation and self-assembles with high fidelity into a double-layered cross-beta structure. Hairpins assemble with an in-register Syn orientation within each beta-sheet layer and with an Anti orientation between layers. Surprisingly, although the MAX1 fibril network is kinetically trapped, solid-state NMR data show that fibrils within this network are monomorphic and most likely represent the thermodynamic ground state. Intermolecular interactions not available in alternative structural arrangements apparently dictate this monomorphic behavior.
C1 [Nagy-Smith, Katelyn; Schneider, Joel] NCI, Chem Biol Lab, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
   [Nagy-Smith, Katelyn] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA.
   [Moore, Eric; Tycko, Robert] NIDDK, Lab Chem Phys, NIH, Bethesda, MD 20892 USA.
RP Tycko, R (reprint author), NIDDK, Lab Chem Phys, NIH, Bethesda, MD 20892 USA.
EM robertty@mail.nih.gov
FU Intramural Research Programs of National Institute of Diabetes and
   Digestive and Kidney Diseases; National Cancer Institute of National
   Institutes of Health
FX This work was supported by the Intramural Research Programs of the
   National Institute of Diabetes and Digestive and Kidney Diseases and the
   National Cancer Institute of the National Institutes of Health.
   Structure calculations were aided by the high-performance computational
   capabilities of the Biowulf Linux cluster at the NIH.
NR 40
TC 12
Z9 12
U1 7
U2 76
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 11
PY 2015
VL 112
IS 32
BP 9816
EP 9821
DI 10.1073/pnas.1509313112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO6RY
UT WOS:000359285100035
PM 26216960
ER

PT J
AU Helb, DA
   Tetteh, KKA
   Felgner, PL
   Skinner, J
   Hubbard, A
   Arinaitwe, E
   Mayanja-Kizza, H
   Ssewanyana, I
   Kamya, MR
   Beeson, JG
   Tappero, J
   Smith, DL
   Crompton, PD
   Rosenthal, PJ
   Dorsey, G
   Drakeley, CJ
   Greenhouse, B
AF Helb, Danica A.
   Tetteh, Kevin K. A.
   Felgner, Philip L.
   Skinner, Jeff
   Hubbard, Alan
   Arinaitwe, Emmanuel
   Mayanja-Kizza, Harriet
   Ssewanyana, Isaac
   Kamya, Moses R.
   Beeson, James G.
   Tappero, Jordan
   Smith, David L.
   Crompton, Peter D.
   Rosenthal, Philip J.
   Dorsey, Grant
   Drakeley, Christopher J.
   Greenhouse, Bryan
TI Novel serologic biomarkers provide accurate estimates of recent
   Plasmodium falciparum exposure for individuals and communities
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE Plasmodium falciparum malaria; antigen discovery; serology;
   immunoepidemiology; epidemiology
ID MALARIA TRANSMISSION INTENSITY; ENTOMOLOGICAL INOCULATION RATE;
   SPOROZOITE SURFACE-ANTIGENS; ANTIBODY-RESPONSES; MEROZOITE ANTIGENS;
   YOUNG-CHILDREN; WESTERN KENYA; CONTROL PROGRAMS; RECOVERY RATES;
   NORTHERN GHANA
AB Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and communities are needed to guide and evaluate malaria control interventions. Serologic assays can potentially produce precise exposure estimates at low cost; however, current approaches based on responses to a few characterized antigens are not designed to estimate exposure in individuals. Pf-specific antibody responses differ by antigen, suggesting that selection of antigens with defined kinetic profiles will improve estimates of Pf exposure. To identify novel serologic biomarkers of malaria exposure, we evaluated responses to 856 Pf antigens by protein microarray in 186 Ugandan children, for whom detailed Pf exposure data were available. Using data-adaptive statistical methods, we identified combinations of antibody responses that maximized information on an individual's recent exposure. Responses to three novel Pf antigens accurately classified whether an individual had been infected within the last 30, 90, or 365 d (cross-validated area under the curve = 0.86-0.93), whereas responses to six antigens accurately estimated an individual's malaria incidence in the prior year. Cross-validated incidence predictions for individuals in different communities provided accurate stratification of exposure between populations and suggest that precise estimates of community exposure can be obtained from sampling a small subset of that community. In addition, serologic incidence predictions from cross-sectional samples characterized heterogeneity within a community similarly to 1 y of continuous passive surveillance. Development of simple ELISA-based assays derived from the successful selection strategy outlined here offers the potential to generate rich epidemiologic surveillance data that will be widely accessible to malaria control programs.
C1 [Helb, Danica A.; Rosenthal, Philip J.; Dorsey, Grant; Greenhouse, Bryan] Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA.
   [Helb, Danica A.] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis, Berkeley, CA 94720 USA.
   [Helb, Danica A.] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94158 USA.
   [Tetteh, Kevin K. A.; Drakeley, Christopher J.] Univ London London Sch Hyg & Trop Med, Dept Immunol & Infect, London WC1E 7HT, England.
   [Felgner, Philip L.] Univ Calif Irvine, Dept Med, Div Infect Dis, Irvine, CA 92697 USA.
   [Skinner, Jeff; Crompton, Peter D.] NIAID, Lab Immunogenet, NIH, Rockville, MD 20852 USA.
   [Hubbard, Alan] Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, Berkeley, CA 94720 USA.
   [Arinaitwe, Emmanuel; Ssewanyana, Isaac] Infect Dis Res Collaborat, Kampala, Uganda.
   [Mayanja-Kizza, Harriet; Kamya, Moses R.] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda.
   [Beeson, James G.] Burnet Inst Med Res & Publ Hlth, Ctr Biomed Res, Melbourne, VIC 3004, Canada.
   [Tappero, Jordan] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30333 USA.
   [Smith, David L.] Univ Oxford, Dept Zool, Spatial Ecol & Epidemiol Grp, Oxford OX1 3PS, England.
   [Smith, David L.] Sanaria Inst Global Hlth & Trop Med, Rockville, MD 20850 USA.
RP Greenhouse, B (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA.
EM bryan.greenhouse@ucsf.edu
RI Crompton, Peter/N-1130-2016; 
OI Mayanja-Kizza, Harriet/0000-0002-9297-6208; Skinner,
   Jeff/0000-0001-5697-0442
FU President's Emergency Plan for AIDS Relief through Centers for Disease
   Control and Prevention Cooperative [OCCU024421]; NIH as part of
   International Centers of Excellence in Malaria Research Program
   [U19AI089674]; Doris Duke Charitable Foundation; Division of Intramural
   Research, National Institute of Allergy and Infectious Diseases, NIH;
   National Health and Medical Research Council of Australia; Doris Duke
   Clinical Scientist Development Award; National Health and Medical
   Research Council Independent Research Institutes Infrastructure Support
   Scheme; Victoria State Government Operational Infrastructure
FX We thank the individuals who participated in this study and their
   families. We also thank Rie Sasaki, Li Liang, and Jozelyn Pablo for
   cloning and generating the microarray data, Robin Anders and Christine
   Langer for providing recombinant proteins, and Nathan Woody for image
   production. We thank the study team and the Makerere
   University-University of California, San Francisco Research
   Collaboration and Infectious Diseases Research Collaboration for
   administrative and technical support. This research has been supported
   by the President's Emergency Plan for AIDS Relief through Centers for
   Disease Control and Prevention Cooperative Agreement Number OCCU024421,
   the NIH as part of International Centers of Excellence in Malaria
   Research Program U19AI089674, and the Doris Duke Charitable Foundation.
   J.S. and P.D.C. are supported by the Division of Intramural Research,
   National Institute of Allergy and Infectious Diseases, NIH. J.G.B. was
   supported by the National Health and Medical Research Council of
   Australia. B.G. is the recipient of a Doris Duke Clinical Scientist
   Development Award. The Burnet Institute is supported by National Health
   and Medical Research Council Independent Research Institutes
   Infrastructure Support Scheme and a Victoria State Government
   Operational Infrastructure Support Grant.
NR 109
TC 24
Z9 24
U1 0
U2 7
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 11
PY 2015
VL 112
IS 32
BP E4438
EP E4447
DI 10.1073/pnas.1501705112
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO6RY
UT WOS:000359285100015
PM 26216993
ER

PT J
AU Li, JJ
   Cao, CN
   Fixsen, SM
   Young, JM
   Ono, C
   Bando, H
   Elde, NC
   Katsuma, S
   Dever, TE
   Sicheri, F
AF Li, John J.
   Cao, Chune
   Fixsen, Sarah M.
   Young, Janet M.
   Ono, Chikako
   Bando, Hisanori
   Elde, Nels C.
   Katsuma, Susumu
   Dever, Thomas E.
   Sicheri, Frank
TI Baculovirus protein PK2 subverts eIF2 alpha kinase function by mimicry
   of its kinase domain C-lobe
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE viral mimicry; lobe-swap; HRI; eIF2 alpha kinase inhibition; PKR
ID DOUBLE-STRANDED-RNA; VACCINIA VIRUS E3; SUBSTRATE RECOGNITION;
   BINDING-SITE; K3L PROTEIN; MOTIF; DIMERIZATION; INHIBITOR; REVEALS;
   ELF2-ALPHA
AB Phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by eIF2 alpha family kinases is a conserved mechanism to limit protein synthesis under specific stress conditions. The baculovirus-encoded protein PK2 inhibits eIF2 alpha family kinases in vivo, thereby increasing viral fitness. However, the precise mechanism by which PK2 inhibits eIF2 alpha kinase function remains an enigma. Here, we probed the mechanism by which PK2 inhibits the model eIF2 alpha kinase human RNA-dependent protein kinase (PKR) as well as native insect eIF2 alpha kinases. Although PK2 structurally mimics the C-lobe of a protein kinase domain and possesses the required docking infrastructure to bind eIF2 alpha, we show that PK2 directly binds the kinase domain of PKR (PKRKD) but not eIF2 alpha. The PKRKD-PK2 interaction requires a 22-residue N-terminal extension preceding the globular PK2 body that we term the "eIF2 alpha kinase C-lobe mimic" (EKCM) domain. The functional insufficiency of the N-terminal extension of PK2 implicates a role for the adjacent EKCM domain in binding and inhibiting PKR. Using a genetic screen in yeast, we isolated PK2-activating mutations that cluster to a surface of the EKCM domain that in bona fide protein kinases forms the catalytic cleft through sandwiching interactions with a kinase N-lobe. Interaction assays revealed that PK2 associates with the N-but not the C-lobe of PKRKD. We propose an inhibitory model whereby PK2 engages the N-lobe of an eIF2 alpha kinase domain to create a nonfunctional pseudokinase domain complex, possibly through a lobe-swapping mechanism. Finally, we show that PK2 enhances baculovirus fitness in insect hosts by targeting the endogenous insect heme-regulated inhibitor (HRI)-like eIF2 alpha kinase.
C1 [Li, John J.; Sicheri, Frank] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Program Syst Biol, Toronto, ON M5G 1X5, Canada.
   [Li, John J.; Sicheri, Frank] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.
   [Cao, Chune; Dever, Thomas E.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA.
   [Fixsen, Sarah M.; Elde, Nels C.] Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84112 USA.
   [Young, Janet M.] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA.
   [Ono, Chikako; Bando, Hisanori] Hokkaido Univ, Grad Sch Agr, Div Agrobiol, Lab Appl Mol Entomol, Sapporo, Hokkaido 0608589, Japan.
   [Katsuma, Susumu] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Agr & Environm Biol, Tokyo 1138657, Japan.
   [Sicheri, Frank] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.
RP Katsuma, S (reprint author), Univ Tokyo, Grad Sch Agr & Life Sci, Dept Agr & Environm Biol, Tokyo 1138657, Japan.
EM katsuma@ss.ab.a.u-tokyo.ac.jp; tdever@nih.gov; sicheri@lunenfeld.ca
RI Sicheri, Frank/F-8856-2013; 
OI Dever, Thomas/0000-0001-7120-9678
FU Canadian Institutes of Health [MOP-84370]; Japan Society for the
   Promotion of Science [19688004, 25292196]; NIH [GM090042, P50 GM107632];
   Intramural Research Program of the NIH; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development; Pew Charitable Trusts
FX We thank Keisuke Shoji for siRNA design, Dr. Harmit Malik for
   discussions and insights into the evolutionary analysis of PK2, Ines
   Drinnenberg for access to lepidopteran transcriptome assemblies, and
   Neroshan Thevakumaran and Dr. Daniel Mao for technical and advisory
   support. This work was supported in part by Canadian Institutes of
   Health Research Grant MOP-84370 (to F.S.), by Japan Society for the
   Promotion of Science Grants-in-Aid for Scientific Research 19688004 and
   25292196 (to S.K.), by NIH Grant GM090042 (to N.C.E.), by the Intramural
   Research Program of the NIH, Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (T.E.D.), by NIH Grant P50
   GM107632 (to J.M.Y.), and by an award from the Pew Charitable Trusts (to
   N.C.E.).
NR 35
TC 2
Z9 2
U1 0
U2 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 11
PY 2015
VL 112
IS 32
BP E4364
EP E4373
DI 10.1073/pnas.1505481112
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO6RY
UT WOS:000359285100007
PM 26216977
ER

PT J
AU Dunn, DM
   Woodford, MR
   Truman, AW
   Jensen, SM
   Schulman, J
   Caza, T
   Remillard, TC
   Loiselle, D
   Wolfgeher, D
   Blagg, BSJ
   Franco, L
   Haystead, TA
   Daturpalli, S
   Mayer, MP
   Trepel, JB
   Morgan, RML
   Prodromou, C
   Kron, SJ
   Panaretou, B
   Stetler-Stevenson, WG
   Landas, SK
   Neckers, L
   Bratslavsky, G
   Bourboulia, D
   Mollapour, M
AF Dunn, Diana M.
   Woodford, Mark R.
   Truman, Andrew W.
   Jensen, Sandra M.
   Schulman, Jacqualyn
   Caza, Tiffany
   Remillard, Taylor C.
   Loiselle, David
   Wolfgeher, Donald
   Blagg, Brian S. J.
   Franco, Lucas
   Haystead, Timothy A.
   Daturpalli, Soumya
   Mayer, Matthias P.
   Trepel, Jane B.
   Morgan, Rhodri M. L.
   Prodromou, Chrisostomos
   Kron, Stephen J.
   Panaretou, Barry
   Stetler-Stevenson, William G.
   Landas, Steve K.
   Neckers, Len
   Bratslavsky, Gennady
   Bourboulia, Dimitra
   Mollapour, Mehdi
TI c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its
   Co-chaperone Function in Cancer Cells
SO CELL REPORTS
LA English
DT Article
ID ATP-BINDING; IN-VIVO; STEROID-RECEPTOR; COCHAPERONE AHA1; HSP90
   FUNCTION; BCR-ABL; INHIBITORS; PROTEINS; HYDROLYSIS; YEAST
AB The ability ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity, tailoring the chaperone function to specific "client'' proteins. The intracellular signaling mechanisms directly regulating Aha1 association with Hsp90 remain unknown. Here, we show that c-Abl kinase phosphorylates Y223 in human Aha1 (hAha1), promoting its interaction with Hsp90. This, consequently, results in an increased Hsp90 ATPase activity, enhances Hsp90 interaction with kinase clients, and compromises the chaperoning of non-kinase clients such as glucocorticoid receptor and CFTR. Suggesting a regulatory paradigm, we also find that Y223 phosphorylation leads to ubiquitination and degradation of hAha1 in the proteasome. Finally, pharmacologic inhibition of c-Abl prevents hAha1 interaction with Hsp90, thereby hypersensitizing cancer cells to Hsp90 inhibitors both in vitro and ex vivo.
C1 [Dunn, Diana M.; Woodford, Mark R.; Schulman, Jacqualyn; Remillard, Taylor C.; Bratslavsky, Gennady; Bourboulia, Dimitra; Mollapour, Mehdi] SUNY Upstate Med Univ, Dept Urol, Syracuse, NY 13210 USA.
   [Dunn, Diana M.; Bourboulia, Dimitra; Mollapour, Mehdi] SUNY Upstate Med Univ, Dept Biochem & Mol Biol, Syracuse, NY 13210 USA.
   [Dunn, Diana M.; Woodford, Mark R.; Schulman, Jacqualyn; Remillard, Taylor C.; Bratslavsky, Gennady; Bourboulia, Dimitra; Mollapour, Mehdi] SUNY Upstate Med Univ, Canc Res Inst, Syracuse, NY 13210 USA.
   [Truman, Andrew W.] Univ N Carolina, Dept Biol Sci, Charlotte, NC 28223 USA.
   [Truman, Andrew W.; Wolfgeher, Donald; Kron, Stephen J.] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA.
   [Jensen, Sandra M.; Stetler-Stevenson, William G.] NCI, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Caza, Tiffany; Landas, Steve K.] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA.
   [Loiselle, David; Haystead, Timothy A.] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA.
   [Blagg, Brian S. J.; Franco, Lucas] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA.
   [Daturpalli, Soumya; Mayer, Matthias P.] Heidelberg Univ, DKFZ ZMBH Alliance, Zentrum Mol Biol, D-69120 Heidelberg, Germany.
   [Trepel, Jane B.] NCI, Dev Therapeut Branch, Bethesda, MD 20892 USA.
   [Morgan, Rhodri M. L.; Prodromou, Chrisostomos] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England.
   [Panaretou, Barry] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England.
   [Neckers, Len] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Mollapour, M (reprint author), SUNY Upstate Med Univ, Dept Urol, 750 E Adams St, Syracuse, NY 13210 USA.
EM mollapom@upstate.edu
OI Woodford, Mark/0000-0002-6737-2832; Dunn, Diana/0000-0003-3244-0599;
   Prodromou, Chrisostomos/0000-0003-4320-1147
FU NCI [R01 CA164492]; Deutsche Forschungsgemeinschaft [SFB638]; Wellcome
   Trust [095605/Z11/Z]; SUNY Up-state Medical University; One Square Mile
   of Hope Foundation
FX We thank Dr. J. Johnson (University of Idaho) for STE11 Delta N plasmid,
   Dr. J.L. Brodsky (University of Pittsburgh) for CFTR-HA plasmid, Dr.
   S.P. Goff (Columbia University) for c-Abl-/- MEF cell line, Dr. G.
   Chiosis (Memorial Sloan-Kettering Cancer Center) for PU-H71, and Dr.
   Weiwen Ying (Synta Pharmaceuticals) for ganetespib. This work was
   supported with funds from NCI R01 CA164492 (A.W.T., D.W., and S.J.K.),
   Deutsche Forschungsgemeinschaft SFB638 (M.P.M.), Wellcome Trust
   095605/Z11/Z (C.P.), and the SUNY Up-state Medical University and One
   Square Mile of Hope Foundation (M.M. and D.B.).
NR 36
TC 7
Z9 7
U1 1
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD AUG 11
PY 2015
VL 12
IS 6
BP 1006
EP 1018
DI 10.1016/j.celrep.2015.07.004
PG 13
WC Cell Biology
SC Cell Biology
GA CO8LW
UT WOS:000359421900010
PM 26235616
ER

PT J
AU Liu, R
   Li, X
   Zhang, ZY
   Zhou, M
   Sun, Y
   Su, DL
   Feng, XB
   Gao, X
   Shi, ST
   Chen, WJ
   Sun, LY
AF Liu, Rui
   Li, Xia
   Zhang, Zhuoya
   Zhou, Min
   Sun, Yue
   Su, Dinglei
   Feng, Xuebing
   Gao, Xiang
   Shi, Songtao
   Chen, Wanjun
   Sun, Lingyun
TI Allogeneic mesenchymal stem cells inhibited T follicular helper cell
   generation in rheumatoid arthritis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
   INTERFERON-GAMMA; DISEASE-ACTIVITY; DENDRITIC CELLS; MRL/LPR MICE;
   B-CELL; TRANSPLANTATION; DIFFERENTIATION; TRYPTOPHAN
AB T follicular helper (Tfh) cells provide help for antigen-specific B cells. We have previously shown that Tfh cell frequency was increased and associated with auto-antibodies in patients with rheumatoid arthritis (RA), suggesting a possible involvement of Tfh cells in its pathogenesis. Mesenchymal stem cells (MSCs) represent a promising alternative cell therapy for RA by modulating T and B cell activation and proliferation. However, it remains unknown whether MSCs have immunoregulation on Tfh cells. In this paper, we have demonstrated that allogeneic MSCs could suppress Tfh cell differentiation in RA patients partly via the production of indoleamine 2,3-dioxygenase (IDO). IFN gamma generated from Tfh cell differentiation system induced IDO expression on MSCs. MSCs transplantation (MSCT) into collagen-induced arthritis (CIA) mice prevented arthritis progression by inhibiting both the number and function of Tfh cells in vivo. These findings reveal a novel suppressive function of MSCs in Tfh cells, which has implication in understanding the underlying mechanisms of the immunotherapeutic effects of MSCs on RA patients.
C1 [Liu, Rui; Zhou, Min; Su, Dinglei; Feng, Xuebing; Sun, Lingyun] Nanjing Med Univ, Dept Immunol & Rheumatol, Drum Tower Clin Med Coll, Nanjing 210008, Jiangsu, Peoples R China.
   [Li, Xia] Dalian Med Univ, Dept Immunol, Coll Basic Med Sci, Dalian 116044, Liaoning, Peoples R China.
   [Zhang, Zhuoya; Sun, Yue] Nanjing Univ, Dept Immunol & Rheumatol, Affliated Drum Tower Hosp, Sch Med, Nanjing 210008, Jiangsu, Peoples R China.
   [Gao, Xiang] Nanjing Univ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210000, Jiangsu, Peoples R China.
   [Shi, Songtao] Univ So Calif, Ostrow Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA.
   [Chen, Wanjun] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, NIH, Bethesda, MD USA.
RP Li, X (reprint author), Dalian Med Univ, Dept Immunol, Coll Basic Med Sci, Dalian 116044, Liaoning, Peoples R China.
EM lixia416@163.com; lingyunsun@nju.edu.cn
FU Major International (Regional) Joint Research Project [81120108021];
   National Natural Science Foundation of China [81172847, 81373214];
   Jiangsu Province Kejiao Xingwei Program; Natural Science Foundation of
   Liaoning [2014022013]; China Postdoctoral Science Foundation
   [2012M510073]; Intramural Research Program of NIH, NIDCR
FX This work was supported by the Major International (Regional) Joint
   Research Project (No. 81120108021), National Natural Science Foundation
   of China (No. 81172847, 81373214); Jiangsu Province Kejiao Xingwei
   Program; Natural Science Foundation of Liaoning (No. 2014022013), China
   Postdoctoral Science Foundation the First Class (2012M510073). W.C. is
   supported by the Intramural Research Program of NIH, NIDCR.
NR 45
TC 4
Z9 5
U1 5
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 11
PY 2015
VL 5
AR 12777
DI 10.1038/srep12777
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO6TD
UT WOS:000359288300001
PM 26259824
ER

PT J
AU Puhl, HL
   Won, YJ
   Lu, V
   Ikeda, SR
AF Puhl, Henry L., III
   Won, Yu-Jin
   Lu, Van B.
   Ikeda, Stephen R.
TI Human GPR42 is a transcribed multisite variant that exhibits copy number
   polymorphism and is functional when heterologously expressed
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PROTEIN-COUPLED RECEPTOR; RAT SYMPATHETIC NEURONS; CHAIN FATTY-ACIDS;
   VOLTAGE-DEPENDENT MODULATION; CALCIUM-CHANNELS; GUT MICROBIOTA;
   SEGMENTAL DUPLICATIONS; GENOME; SUBUNITS; DISEASE
AB FFAR3 (GPR41) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands. The receptor is found on gut enteroendocrine L-cells, pancreatic beta-cells, and sympathetic neurons, and is implicated in obesity, diabetes, allergic airway disease, and altered immune function. In primates, FFAR3 is segmentally duplicated resulting in GPR42, a gene currently classified as a suspected pseudogene. In this study, we sequenced FFAR3 and GPR42 open reading frames from 56 individuals and found an unexpectedly high frequency of polymorphisms contributing to several complex haplotypes. We also identified a frequent (18.8%) structural variation that results in GPR42 copy number polymorphism. Finally, sequencing revealed that 50.6% of GPR42 haplotypes differed from FFAR3 by only a single non-synonymous substitution and that the GPR42 reference sequence matched only 4.4% of the alleles. Sequencing of cDNA from human sympathetic ganglia and colon revealed processed transcripts matching the GPR42 genotype. Expression of several GPR42 haplotypes in rat sympathetic neurons revealed diverse pharmacological phenotypes that differed in potency and efficacy. Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.
C1 [Puhl, Henry L., III; Won, Yu-Jin; Lu, Van B.; Ikeda, Stephen R.] NIAAA, Sect Transmitter Signaling, Lab Mol Physiol, NIA, Bethesda, MD 20892 USA.
RP Ikeda, SR (reprint author), NIAAA, Sect Transmitter Signaling, Lab Mol Physiol, NIA, Bethesda, MD 20892 USA.
EM sikeda@mail.nih.gov
FU intramural program at the National Institutes of Health, National
   Institute on Alcohol Abuse and Alcoholism
FX We thank Dr. David Goldman, Dr. Colin Hodgkinson, Dr. Mary-Anne Enoch,
   and Ms. Cheryl Marietta (NIH/NIAAA) for providing human genomic DNA
   samples and valuable discussion. Dr. Arjun Prasad (NIH/NHGRI) provided
   valuable insight and advice during the project. We thank Dr. Kathy Grant
   and Dr. Betsy Ferguson (OHSU, Portland, OR) for supplying Rhesus macaque
   genomic DNA samples. This work was supported by the intramural program
   at the National Institutes of Health, National Institute on Alcohol
   Abuse and Alcoholism.
NR 51
TC 3
Z9 3
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 11
PY 2015
VL 5
AR 12880
DI 10.1038/srep12880
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO6TM
UT WOS:000359289200001
PM 26260360
ER

PT J
AU Murphy, CC
   Harlan, LC
   Warren, JL
   Geiger, AM
AF Murphy, Caitlin C.
   Harlan, Linda C.
   Warren, Joan L.
   Geiger, Ann M.
TI Race and Insurance Differences in the Receipt of Adjuvant Chemotherapy
   Among Patients With Stage III Colon Cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID COLORECTAL-CANCER; UNITED-STATES; RACIAL DISPARITIES; AFRICAN-AMERICANS;
   ECONOMIC BURDEN; MEDICAL-CARE; RISK-FACTORS; PHASE-III; FLUOROURACIL;
   THERAPY
AB Purpose
   Although the incidence and mortality of colon cancer in the United States has declined over the past two decades, blacks have worse outcomes than whites. Variations in treatment may contribute to mortality differentials.
   Methods
   Patients diagnosed with stage III colon cancer were randomly sampled from the SEER program from the years 1990, 1991, 1995, 2000, 2005, and 2010. Patients were categorized as non-Hispanic white (n = 835) or black (n = 384). Treatment data were obtained from a review of the medical records, and these data were verified through contact with the original treating physicians. Log-binomial regression models were used to estimate the association between race and receipt of adjuvant chemotherapy. Effect modification by insurance was assessed with use of single referent models.
   Results
   Receipt of adjuvant chemotherapy among both white and black patients increased from the period encompassing the years 1990 and 1991 (white, 58%; black, 45%) to the year 2005 (white, 72%; black, 71%) and then decreased in the year 2010 (white, 66%; black, 57%). There were marked racial disparities in the time period of 1990 to 1991 and again in 2010, with black patients less likely to receive adjuvant chemotherapy as compared with white patients (risk ratio [RR], .82; 95% CI, .72 to .93). For black patients, receipt of adjuvant chemotherapy did not differ across insurance categories (RR for private insurance, .80; 95% CI, .69 to .93; RR for Medicare, .84; 95% CI, .69 to 1.02; and RR for Medicaid, .84; 95% CI, .69 to 1.02), although a larger proportion had Medicaid in all years of the study as compared with white patients.
   Conclusion
   The chemotherapy differential narrowed after the time period of 1990 to 1991, but our findings suggest that the disparity reemerged in 2010. Recent decreases in chemotherapy use may be due, in part, to the economic downturn and an increase in Medicaid coverage.
C1 [Murphy, Caitlin C.] Univ N Carolina, Chapel Hill, NC 27599 USA.
   [Harlan, Linda C.; Warren, Joan L.; Geiger, Ann M.] NCI, Div Canc Control & Populat Sci, Rockville, MD USA.
RP Murphy, CC (reprint author), Univ N Carolina, Gillings Sch Publ Hlth, Dept Epidemiol, 135 Dauer Dr,2101 McGavran Greenberg Hall,CB 7435, Chapel Hill, NC 27599 USA.
EM caitlin_murphy@med.unc.edu
FU National Institutes of Health [T32 DK07634]; National Cancer Institute
   [HHSN261201000024C, HSN261201000025C, HHSN261201000032C,
   HHSN261201000027C, HHSN261201000026C, HHSN261201000140C,
   HHSN261201000037C, HHSN261201000033C, HSN261201000034C,
   HHSN261201000035C, HHSN261201000029C, HHSN261201000031C,
   HSN261201000028C, HHSN261201000030C]
FX Supported by National Institutes of Health Grant No. T32 DK07634
   (C.C.M.) and National Cancer Institute Contracts No. HHSN261201000024C,
   HSN261201000025C, HHSN261201000032C, HHSN261201000027C,
   HHSN261201000026C, HHSN261201000140C, HHSN261201000037C,
   HHSN261201000033C, HSN261201000034C, HHSN261201000035C,
   HHSN261201000029C, HHSN261201000031C, HSN261201000028C, and
   HHSN261201000030C.
NR 61
TC 13
Z9 13
U1 1
U2 2
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 10
PY 2015
VL 33
IS 23
BP 2530
EP U72
DI 10.1200/JCO.2015.61.3026
PG 9
WC Oncology
SC Oncology
GA CR9DY
UT WOS:000361654600009
PM 26150445
ER

PT J
AU Prasad, PK
   Hardy, KK
   Zhang, N
   Edelstein, K
   Srivastava, D
   Zeltzer, L
   Stovall, M
   Seibel, NL
   Leisenring, W
   Armstrong, GT
   Robison, LL
   Krull, K
AF Prasad, Pinki K.
   Hardy, Kristina K.
   Zhang, Nan
   Edelstein, Kim
   Srivastava, Deokumar
   Zeltzer, Lonnie
   Stovall, Marilyn
   Seibel, Nita L.
   Leisenring, Wendy
   Armstrong, Gregory T.
   Robison, Leslie L.
   Krull, Kevin
TI Psychosocial and Neurocognitive Outcomes in Adult Survivors of
   Adolescent and Early Young Adult Cancer: A Report From the Childhood
   Cancer Survivor Study
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; BRAIN; CHILDREN; PUBERTY; COHORT; RISK
AB Purpose
   To characterize psychological and neurocognitive function in long-term cancer survivors diagnosed during adolescence and early young adulthood (AeYA).
   Methods
   Six thousand one hundred ninety-two survivors and 390 siblings in the Childhood Cancer Survivor Study completed the Brief Symptom Inventory-18 and a Neurocognitive Questionnaire. Treatment and demographic predictors were examined, and associations with social attainment (employment, education, and living independently) were evaluated. Logistic regression models were used to compute odds ratios (ORs) and corresponding 95% CIs.
   Results
   Among survivors, 2,589 were diagnosed when AeYA (11 to 21 years old). Adjusted for current age and sex, these survivors, compared with siblings, self-reported higher rates of depression (11.7% v 8.0%, respectively; OR, 1.55; 95% CI, 1.04 to 2.30) and anxiety (7.4% v 4.4%, respectively; OR, 2.00; 95% CI, 1.17 to 3.43) and more problems with task efficiency (17.2% v 10.8%, respectively; OR, 1.72; 95% CI, 1.21 to 2.43), emotional regulation (19.1% v 14.1%, respectively; OR, 1.74; 95% CI, 1.26 to 2.40), and memory (25.9% v 19.0%, respectively; OR, 1.44; 95% CI, 1.09 to 1.89). Few differences were noted between survivors diagnosed with leukemia or CNS tumor before 11 years old versus during later adolescence, although those diagnosed with lymphoma or sarcoma during AeYA were at reduced risk for self-reported psychosocial and neurocognitive problems. Unemployment was associated with self-reports of impaired task efficiency (OR, 2.93; 95% CI, 2.28 to 3.77), somatization (OR, 2.29; 95% CI, 1.77 to 2.98), and depression (OR, 1.94; 95% CI, 1.43 to 2.63).
   Conclusion
   We demonstrated that risk for poor functional outcome is not limited to survivors' diagnoses in early childhood. AeYA is a critical period of development, and cancer during this period can impact neurocognitive and emotional function and disrupt vocational attainment. (C) 2015 by American Society of Clinical Oncology
C1 [Prasad, Pinki K.] Louisiana State Univ, Sch Med, New Orleans, LA 70018 USA.
   [Hardy, Kristina K.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
   [Zhang, Nan; Srivastava, Deokumar; Armstrong, Gregory T.; Robison, Leslie L.; Krull, Kevin] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Zeltzer, Lonnie] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Stovall, Marilyn] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Seibel, Nita L.] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
   [Leisenring, Wendy] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Edelstein, Kim] Princess Margaret Canc Ctr, Toronto, ON, Canada.
RP Prasad, PK (reprint author), Louisiana State Univ, Sch Hlth Sci Ctr, 200 Henry Clay Ave, New Orleans, LA 70018 USA.
EM pprasa@lsuhsc.edu
FU National Cancer Institute, Bethesda, MD [CA55727]
FX Supported by Grant No. CA55727 from the National Cancer Institute,
   Bethesda, MD (G. T. A.).
NR 30
TC 9
Z9 9
U1 2
U2 19
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 10
PY 2015
VL 33
IS 23
BP 2545
EP U91
DI 10.1200/JCO.2014.57.7528
PG 10
WC Oncology
SC Oncology
GA CR9DY
UT WOS:000361654600011
PM 26150441
ER

PT J
AU Baker, SG
   Kramer, BS
AF Baker, Stuart G.
   Kramer, Barnett S.
TI Evaluating Prognostic Markers Using Relative Utility Curves and Test
   Tradeoffs
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID BREAST-CANCER RISK; PREDICTION MODELS; VALIDATION; PERFORMANCE; ACCURACY
C1 [Baker, Stuart G.; Kramer, Barnett S.] NCI, Bethesda, MD 20892 USA.
RP Baker, SG (reprint author), 9609 Med Ctr Dr,MSC 9789, Bethesda, MD 20892 USA.
EM sb16i@nih.gov
FU Division of Cancer Prevention of the National Cancer Institute
FX Supported by the Division of Cancer Prevention of the National Cancer
   Institute.
NR 20
TC 2
Z9 2
U1 1
U2 4
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD AUG 10
PY 2015
VL 33
IS 23
BP 2578
EP U150
DI 10.1200/JCO.2014.58.0092
PG 4
WC Oncology
SC Oncology
GA CR9DY
UT WOS:000361654600014
PM 26124476
ER

PT J
AU Park, C
   Arthos, J
   Cicala, C
   Kehrl, JH
AF Park, Chung
   Arthos, James
   Cicala, Claudia
   Kehrl, John H.
TI The HIV-1 envelope protein gp120 is captured and displayed for B cell
   recognition by SIGN-R1(+) lymph node macrophages
SO ELIFE
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; DENDRITIC CELLS; MEDIATES UPTAKE; MARGINAL
   ZONE; T-CELLS; ANTIGEN; TYPE-1; POLYSACCHARIDE; INDIVIDUALS; EXPRESSION
AB The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown. Here, we show that following local gp120 injection lymph node (LN) SIGN-R1(+) sinus macrophages located in interfollicular pockets and underlying SIGN-R1(+) macrophages form a cellular network that rapidly captures gp120 from the afferent lymph. In contrast, two other antigens, phycoerythrin and hen egg lysozyme, were not captured by these cells. Intravital imaging of mouse LNs revealed persistent, but transient interactions between gp120 bearing interfollicular network cells and both trafficking and LN follicle resident gp120 specific B cells. The gp120 specific, but not the control B cells repetitively extracted gp120 from the network cells. Our findings reveal a specialized LN antigen delivery system poised to deliver gp120 and likely other pathogen derived glycoproteins to B cells.
C1 [Park, Chung; Kehrl, John H.] NIAID, B Cell Mol Immunol Sect, Immunoregulat Lab, Bethesda, MD 20892 USA.
   [Arthos, James; Cicala, Claudia] NIAID, Immunopathogenesis Sect, Immunoregulat Lab, Bethesda, MD 20892 USA.
RP Kehrl, JH (reprint author), NIAID, B Cell Mol Immunol Sect, Immunoregulat Lab, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM jkehrl@niaid.nih.gov
FU Division of Intramural Research, National Institute of Allergy and
   Infectious Diseases (Division of Intramural Research of the NIAID)
FX Division of Intramural Research, National Institute of Allergy and
   Infectious Diseases (Division of Intramural Research of the NIAID)
NR 39
TC 2
Z9 2
U1 0
U2 3
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 10
PY 2015
VL 4
AR e06467
DI 10.7554/eLife.06467
PG 23
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA CQ0KC
UT WOS:000360283000001
ER

PT J
AU Wieczfinska, J
   Sokolowska, M
   Pawliczak, R
AF Wieczfinska, Joanna
   Sokolowska, Milena
   Pawliczak, Rafal
TI NOX Modifiers-Just a Step Away from Application in the Therapy of Airway
   Inflammation?
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID NADPH-OXIDASE ACTIVITY; CHRONIC GRANULOMATOUS-DISEASE;
   SMOOTH-MUSCLE-CELLS; ACUTE LUNG INJURY; IDIOPATHIC PULMONARY-FIBROSIS;
   EXHALED BREATH CONDENSATE; SUPEROXIDE-GENERATING ENZYME; GP91(PHOX)
   GENE-EXPRESSION; MUC5AC MUCIN EXPRESSION; OXIDATIVE STRESS
AB Significance: NADPH oxidase (NOX) enzymes, which are widely expressed in different airway cell types, not only contribute to the maintenance of physiological processes in the airways but also participate in the pathogenesis of many acute and chronic diseases. Therefore, the understanding of NOX isoform regulation, expression, and the manner of their potent inhibition might lead to effective therapeutic approaches. Recent Advances: The study of the role of NADPH oxidases family in airway physiology and pathophysiology should be considered as a work in progress. While key questions still remain unresolved, there is significant progress in terms of our understanding of NOX importance in airway diseases as well as a more efficient way of using NOX modifiers in human settings. Critical Issues: Agents that modify the activity of NADPH enzyme components would be considered useful tools in the treatment of various airway diseases. Nevertheless, profound knowledge of airway pathology, as well as the mechanisms of NOX regulation is needed to develop potent but safe NOX modifiers. Future Directions: Many compounds seem to be promising candidates for development into useful therapeutic agents, but their clinical potential is yet to be demonstrated. Further analysis of basic mechanisms in human settings, high-throughput compound scanning, clinical trials with new and existing molecules, and the development of new drug delivery approaches are the main directions of future studies on NOX modifiers. In this article, we discuss the current knowledge with regard to NOX isoform expression and regulation in airway inflammatory diseases as well as the aptitudes and therapeutic potential of NOX modifiers. Antioxid. Redox Signal. 23, 428-445.
C1 [Wieczfinska, Joanna; Pawliczak, Rafal] Med Univ Lodz, Dept Immunopathol, Fac Biomed Sci & Postgrad Training, PL-90752 Lodz, Poland.
   [Sokolowska, Milena] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Pawliczak, R (reprint author), Med Univ Lodz, Dept Immunopathol, Fac Biomed Sci & Postgrad Training, 7-9 Zeligowskiego St, PL-90752 Lodz, Poland.
EM rafal.pawliczak@csk.umed.lodz.pl
RI Wieczfinska, Joanna/S-9723-2016; Pawliczak, Rafal/S-9649-2016
NR 178
TC 0
Z9 0
U1 2
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG 10
PY 2015
VL 23
IS 5
BP 428
EP 445
DI 10.1089/ars.2013.5783
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CP0YA
UT WOS:000359601600005
PM 24383678
ER

PT J
AU Akbari, M
   Sykora, P
   Bohr, VA
AF Akbari, Mansour
   Sykora, Peter
   Bohr, Vilhelm A.
TI Slow mitochondrial repair of 5 '-AMP renders mtDNA susceptible to damage
   in APTX deficient cells
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BASE EXCISION-REPAIR; STRAND BREAK REPAIR; ATAXIA-OCULOMOTOR APRAXIA-1;
   DNA-LIGASE III; PROTEIN APRATAXIN; GENOME INTEGRITY; POLYMERASE-BETA;
   RIBONUCLEOTIDES; REPLICATION; DISEASE
AB Aborted DNA ligation events in eukaryotic cells can generate 5'-adenylated (5'-AMP) DNA termini that can be removed from DNA by aprataxin (APTX). Mutations in APTX cause an inherited human disease syndrome characterized by early-onset progressive ataxia with ocular motor apraxia (AOA1). APTX is found in the nuclei and mitochondria of eukaryotic cells. Depletion of APTX causes mitochondrial dysfunction and renders the mitochondrial genome, but not the nuclear genome susceptible to damage. The biochemical processes that link APTX deficiency to mitochondrial dysfunction have not been well elucidated. Here, we monitored the repair of 5'-AMP DNA damage in nuclear and mitochondrial extracts from human APTX(+/+) and APTX(-/-) cells. The efficiency of repair of 5'-AMP DNA was much lower in mitochondrial than in nuclear protein extracts, and resulted in persistent DNA repair intermediates in APTX deficient cells. Moreover, the removal of 5'-AMP from DNA was significantly slower in the mitochondrial extracts from human cell lines and mouse tissues compared with their corresponding nuclear extracts. These results suggest that, contrary to nuclear DNA repair, mitochondrial DNA repair is not able to compensate for APTX deficiency resulting in the accumulation of mitochondrial DNA damage.
C1 [Akbari, Mansour; Bohr, Vilhelm A.] Univ Copenhagen, SUND, Ctr Hlth Aging, DK-1168 Copenhagen, Denmark.
   [Sykora, Peter; Bohr, Vilhelm A.] NIA, Lab Mol Gerontol, Baltimore, MD 21224 USA.
RP Bohr, VA (reprint author), Univ Copenhagen, SUND, Ctr Hlth Aging, DK-1168 Copenhagen, Denmark.
EM vbohr@nih.gov
OI Akbari, Mansour/0000-0002-6490-7766
FU Intramural Program of The National Institutes on Aging, National
   Institutes of Health, USA; NORDEA Foundation, Denmark
FX We would like to thank Dr. Daniel R. McNeill for C3ABR and L938 cell
   lines. We acknowledge Dr. Morten Scheibye-Knudsen for the development of
   the mitochondrial disease database, www.Mitodb.com. Support received
   from the Intramural Program of The National Institutes on Aging,
   National Institutes of Health, USA. This work was funded by the NORDEA
   Foundation, Denmark.
NR 47
TC 4
Z9 4
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 10
PY 2015
VL 5
AR 12876
DI 10.1038/srep12876
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO5KC
UT WOS:000359197000002
PM 26256098
ER

PT J
AU Nayak, KS
   Nielsen, JF
   Bernstein, MA
   Markl, M
   Gatehouse, PD
   Botnar, RM
   Saloner, D
   Lorenz, C
   Wen, H
   Hu, BS
   Epstein, FH
   Oshinski, JN
   Raman, SV
AF Nayak, Krishna S.
   Nielsen, Jon-Fredrik
   Bernstein, Matt A.
   Markl, Michael
   Gatehouse, Peter D.
   Botnar, Rene M.
   Saloner, David
   Lorenz, Christine
   Wen, Han
   Hu, Bob S.
   Epstein, Frederick H.
   Oshinski, John N.
   Raman, Subha V.
TI Cardiovascular magnetic resonance phase contrast imaging
SO JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
LA English
DT Review
DE CMR flow imaging; Phase contrast; Valvular disease; Congenital defects
ID WALL SHEAR-STRESS; BLOOD-FLOW-VELOCITY; K-T BLAST; PRINCIPAL COMPONENT
   ANALYSIS; MYOCARDIAL MOTION TRACKING; TURBULENT STENOTIC JETS; BASE-LINE
   CORRECTION; PULSE-WAVE VELOCITY; CORONARY-ARTERY; IN-VIVO
AB Cardiovascular magnetic resonance (CMR) phase contrast imaging has undergone a wide range of changes with the development and availability of improved calibration procedures, visualization tools, and analysis methods. This article provides a comprehensive review of the current state-of-the-art in CMR phase contrast imaging methodology, clinical applications including summaries of past clinical performance, and emerging research and clinical applications that utilize today's latest technology.
C1 [Nayak, Krishna S.] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
   [Nielsen, Jon-Fredrik] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA.
   [Bernstein, Matt A.] Mayo Clin, Rochester, MN USA.
   [Markl, Michael] Northwestern Univ, Dept Radiol, Chicago, IL 60611 USA.
   [Gatehouse, Peter D.] Royal Brompton Hosp, Cardiovasc Biomed Res Unit, London SW3 6LY, England.
   [Botnar, Rene M.] Kings Coll London, Cardiovasc Imaging, Div Imaging Sci, London, England.
   [Saloner, David] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA.
   [Lorenz, Christine] Siemens Corp, Ctr Appl Med Imaging, Baltimore, MD USA.
   [Wen, Han] Natl Heart Lung & Blood Inst, Imaging Phys Lab, Bethesda, MD USA.
   [Hu, Bob S.] Palo Alto Med Fdn, Palo Alto, CA USA.
   [Epstein, Frederick H.] Univ Virginia, Dept Radiol, Charlottesville, VA USA.
   [Epstein, Frederick H.] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA.
   [Oshinski, John N.] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA.
   [Oshinski, John N.] Emory Univ, Dept Biomed Engn, Atlanta, GA 30322 USA.
   [Raman, Subha V.] Ohio State Univ, Div Cardiovasc Med, Columbus, OH 43210 USA.
RP Nayak, KS (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, 3740 McClintock Ave,EEB 406, Los Angeles, CA 90089 USA.
EM knayak@usc.edu
RI Markl, Michael/F-7436-2011; Wen, Han/G-3081-2010; 
OI Wen, Han/0000-0001-6844-2997; Nielsen, Jon-Fredrik/0000-0002-2058-3579;
   Bernstein, Matt/0000-0003-3770-0441
FU GE; Siemens
FX KSN and BSH receive research support from GE. SVR, PDG, and FHE receive
   research support from Siemens. CL is an employee of Siemens. BSH has
   equity interest in HeartVista Inc. The authors declare that they have no
   competing interests.
NR 259
TC 11
Z9 12
U1 3
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1097-6647
EI 1532-429X
J9 J CARDIOVASC MAGN R
JI J. Cardiov. Magn. Reson.
PD AUG 9
PY 2015
VL 17
AR 71
DI 10.1186/s12968-015-0172-7
PG 26
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA CO4UH
UT WOS:000359155700001
PM 26254979
ER

PT J
AU Altman, MO
   Bennink, JR
   Yewdell, JW
   Herrin, BR
AF Altman, Meghan O.
   Bennink, Jack R.
   Yewdell, Jonathan W.
   Herrin, Brantley R.
TI Lamprey VLRB response to influenza virus supports universal rules of
   immunogenicity and antigenicity
SO ELIFE
LA English
DT Article
ID VARIABLE LYMPHOCYTE RECEPTORS; MONOCLONAL-ANTIBODIES; RECOGNITION;
   DIVERSITY; EVOLUTION; BINDING; DIVERSIFICATION; FEATURES; SURFACE; SITES
AB Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies (Abs) to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses similar to 80% of the response on hemagglutinin (HA), mainly through recognition of the major antigenic sites in the HA globular head domain. Our findings predict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal models for understanding human Ab responses to viruses and protein immunogens.
C1 [Altman, Meghan O.; Bennink, Jack R.; Yewdell, Jonathan W.] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA.
   [Herrin, Brantley R.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
RP Yewdell, JW (reprint author), NIAID, Viral Dis Lab, Bethesda, MD 20892 USA.
EM jyewdell@nih.gov
OI Herrin, Brantley/0000-0002-1842-6806
FU Division of Intramural Research, National Institute of Allergy and
   Infectious Diseases; National Institutes of Health [R01 AI072435];
   Georgia Research Alliance [R01 GM100151]
FX Division of Intramural Research, National Institute of Allergy and
   Infectious Diseases Meghan O Altman, Jack R Bennink, Jonathan W Yewdell;
   National Institutes of Health R01 AI072435 Brantley R Herrin; Georgia
   Research Alliance R01 GM100151 Brantley R Herrin
NR 31
TC 1
Z9 1
U1 0
U2 11
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 7
PY 2015
VL 4
AR e07467
DI 10.7554/eLife.07467
PG 13
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA CQ0KE
UT WOS:000360283200001
ER

PT J
AU Wang, SB
   Awad, KS
   Elinoff, JM
   Dougherty, EJ
   Ferreyra, GA
   Wang, JY
   Cai, RM
   Sun, JF
   Ptasinska, A
   Danner, RL
AF Wang, Shuibang
   Awad, Keytam S.
   Elinoff, Jason M.
   Dougherty, Edward J.
   Ferreyra, Gabriela A.
   Wang, Jennifer Y.
   Cai, Rongman
   Sun, Junfeng
   Ptasinska, Anetta
   Danner, Robert L.
TI G Protein-coupled Receptor 40 (GPR40) and Peroxisome
   Proliferator-activated Receptor gamma (PPAR gamma) AN INTEGRATED
   TWO-RECEPTOR SIGNALING PATHWAY
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID FREE FATTY-ACIDS; P38 MAPK; COACTIVATOR PGC-1-ALPHA; GLUCOSE-METABOLISM;
   INSULIN-SECRETION; DIABETES-MELLITUS; ENDOTHELIAL-CELLS; DEPENDENT
   MANNER; RETINOIC ACID; KINASE
AB Peroxisome proliferator-activated receptor gamma (PPAR gamma) ligands have been widely used to treat type 2 diabetes mellitus. However, knowledge of PPAR gamma signaling remains incomplete. In addition to PPAR gamma, these drugs also activate G protein-coupled receptor 40 (GPR40), a G alpha(q)-coupled free fatty acid receptor linked to MAPK networks and glucose homeostasis. Notably, p38 MAPK activation has been implicated in PPAR gamma signaling. Here, rosiglitazone (RGZ) activation of GPR40 and p38 MAPK was found to boost PPAR gamma-induced gene transcription in human endothelium. Inhibition or knockdown of p38 MAPK or expression of a dominant negative (DN) p38 MAPK mutant blunted RGZ-induced PPAR gamma DNA binding and reporter activity in EA.hy926 human endothelial cells. GPR40 inhibition or knockdown, or expression of a DN-G(alpha)q mutant likewise blocked activation of both p38 MAPK and PPAR gamma reporters. Importantly, RGZ induction of PPAR gamma target genes in primary human pulmonary artery endothelial cells (PAECs) was suppressed by knockdown of either p38 MAPK or GPR40. GPR40/PPAR gamma signal transduction was dependent on p38 MAPK activation and induction of PPAR gamma co-activator-1 (PGC1 alpha). Silencing of p38 MAPK or GPR40 abolished the ability of RGZ to induce phosphorylation and expression of PGC1 alpha in PAECs. Knockdown of PGC1 alpha, its essential activator SIRT1, or its binding partner/co-activator EP300 inhibited RGZ induction of PPAR gamma-regulated genes in PAECs. RGZ/GPR40/p38 MAPK signaling also led to EP300 phosphorylation, an event that enhances PPAR gamma target gene transcription. Thus, GPR40 and PPAR gamma can function as an integrated two-receptor signal transduction pathway, a finding with implications for rational drug development.
C1 [Wang, Shuibang; Awad, Keytam S.; Elinoff, Jason M.; Dougherty, Edward J.; Ferreyra, Gabriela A.; Wang, Jennifer Y.; Cai, Rongman; Sun, Junfeng; Ptasinska, Anetta; Danner, Robert L.] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Danner, RL (reprint author), NIH, Dept Crit Care Med, 10 Ctr Dr,Rm 2C145, Bethesda, MD 20892 USA.
EM rdanner@nih.gov
RI Regan, Clinton/E-6250-2012
FU National Institutes of Health
FX This work was supported, in whole or in part, by National Institutes of
   Health intramural funds. The authors declare that they have no conflicts
   of interest with the contents of this article.
NR 66
TC 5
Z9 5
U1 2
U2 8
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 7
PY 2015
VL 290
IS 32
BP 19544
EP 19557
DI 10.1074/jbc.M115.638924
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CO7TL
UT WOS:000359364600018
PM 26105050
ER

PT J
AU Hyman, DM
   Eaton, AA
   Gounder, MM
   Pamer, EG
   Pettiford, J
   Carvajal, RD
   Ivy, SP
   Iasonos, A
   Spriggs, DR
AF Hyman, David M.
   Eaton, Anne A.
   Gounder, Mrinal M.
   Pamer, Erika G.
   Pettiford, Jasmine
   Carvajal, Richard D.
   Ivy, S. Percy
   Iasonos, Alexia
   Spriggs, David R.
TI Predictors of early treatment discontinuation in patients enrolled on
   Phase I oncology trials
SO ONCOTARGET
LA English
DT Article
DE Phase I trials; Early Discontinuation; Drug Development
ID CANCER CLINICAL-TRIALS; PROGNOSTIC SCORE; VALIDATION; EXPERIENCE;
   INSTITUTE; PROGRAM; CONTEXT
AB Purpose
   Patients who do not complete one cycle of therapy on Phase I trials for reasons other than dose limiting toxicity (DLT) are considered inevaluable for toxicity and must be replaced.
   Methods
   Individual records from patients enrolled to NCI-sponsored Phase I trials activated between 2000 and 2010 were used. Early discontinuation was defined as the failure to begin cycle 2 for reasons other than a DLT during cycle 1. A multinomial logistic regression with a 3-level nominal outcome (early discontinuation, DLT during cycle 1, and continuation to cycle 2) was used with continuation to cycle 2 serving as the reference category. The final model was used to create two risk scores. An independent external cohort was used to validate these models.
   Results
   Data from 3079 patients on 127 Phase I trials were analyzed. ECOG performance status (1, = 2, two-sided P =.0315 and P =.0007), creatinine clearance (< 60 ml/min, P =.0455), alkaline phosphatase (> 2.5xULN, P =.0026), AST (> ULN, P =.0076), hemoglobin (< 10 g/dL, P <.0001), albumin (< 3.5 g/dL, P <.0001), and platelets (< 400x109/L, P =.0732) were predictors of early discontinuation. The c-index of the final model was 0.63.
   Conclusion
   Knowledge of risk factors for early treatment discontinuation in conjunction with clinical judgment can help guide Phase I patient selection.
C1 [Hyman, David M.; Gounder, Mrinal M.; Pamer, Erika G.; Pettiford, Jasmine; Carvajal, Richard D.; Spriggs, David R.] Mem Sloan Kettering Canc Ctr, Dept Med, Dev Therapeut, New York, NY 10065 USA.
   [Eaton, Anne A.; Iasonos, Alexia] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA.
   [Ivy, S. Percy] NCI, Bethesda, MD 20892 USA.
   [Hyman, David M.; Gounder, Mrinal M.; Carvajal, Richard D.; Iasonos, Alexia; Spriggs, David R.] Weill Cornell Med Coll, New York, NY 10065 USA.
RP Hyman, DM (reprint author), Mem Sloan Kettering Canc Ctr, Dept Med, Dev Therapeut, New York, NY 10065 USA.
EM hymand@mskcc.org
FU Cancer Center core grant [P30 CA008748]
FX Funded in part by the Cancer Center core grant P30 CA008748. The core
   grant provides funding to institutional cores, such as Biostatistics,
   which was used in this study.
NR 23
TC 0
Z9 0
U1 0
U2 2
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD AUG 7
PY 2015
VL 6
IS 22
BP 19316
EP 19327
PG 12
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA CO7RS
UT WOS:000359360000048
PM 25682870
ER

PT J
AU Chatterjee, A
   Ratner, DM
   Ryan, CM
   Johnson, PJ
   O'Keefe, BR
   Secor, WE
   Anderson, DJ
   Robbins, PW
   Samuelson, J
AF Chatterjee, Aparajita
   Ratner, Daniel M.
   Ryan, Christopher M.
   Johnson, Patricia J.
   O'Keefe, Barry R.
   Secor, W. Evan
   Anderson, Deborah J.
   Robbins, Phillips W.
   Samuelson, John
TI Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas
   vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas
   foetus in a Mouse Vaginal Model
SO PLOS ONE
LA English
DT Article
ID MANNOSE-BINDING LECTIN; CHLAMYDIA-TRACHOMATIS; INNATE IMMUNITY; LINKED
   GLYCANS; CYANOVIRIN-N; INFECTION; EXPRESSION; HIV-1; GRIFFITHSIN;
   VACCINE
AB Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus causes premature abortion in cattle. Our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of HIV, on adherence of Trichomonas to ectocervical cells and on Tritrichomonas infections in a mouse model. We show that Trichomonas Asn-linked glycans (N-glycans), like those of HIV, bind the mannose-binding lectin (MBL) that is part of the innate immune system. N-glycans of Trichomonas and Tritrichomonas bind anti-retroviral lectins (cyanovirin-N and griffithsin) and the 2G12 monoclonal antibody, each of which binds HIV N-glycans. Binding of cyanovirin-N appears to be independent of susceptibility to metronidazole, the major drug used to treat Trichomonas. Anti-retroviral lectins, MBL, and galectin-1 cause Trichomonas to self-aggregate and precipitate. The anti-retroviral lectins also increase adherence of ricin-resistant mutants, which are less adherent than parent cells, to ectocervical cell monolayers and to organotypic EpiVaginal tissue cells. Topical application of either anti-retroviral lectins or yeast N-glycans decreases by 40 to 70% the recovery of Tritrichomonas from the mouse vagina. These results, which are explained by a few simple models, suggest that the anti-retroviral lectins have a modest potential for preventing or treating human infections with Trichomonas.
C1 [Chatterjee, Aparajita; Ratner, Daniel M.; Robbins, Phillips W.; Samuelson, John] Boston Univ, Dept Mol & Cell Biol, Sch Dent Med, Boston, MA 02215 USA.
   [Ryan, Christopher M.; Johnson, Patricia J.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA.
   [O'Keefe, Barry R.] Frederick Natl Lab Canc Res, Ctr Canc Res, Mol Targets Lab, Frederick, MD USA.
   [Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA.
   [Anderson, Deborah J.] Boston Med Ctr, Dept Obstet & Gynecol, Boston, MA USA.
RP Samuelson, J (reprint author), Boston Univ, Dept Mol & Cell Biol, Sch Dent Med, Boston, MA 02215 USA.
EM jsamuels@bu.edu
FU Boston University Flow Cytometry Core Facility; National Institutes of
   Health, General Medical Science; National Institutes of Allergy and
   Infectious Diseases [GM031318, AI105779]
FX This work was supported by the Boston University Flow Cytometry Core
   Facility, the National Institutes of Health, General Medical Science,
   GM031318 National Institutes of Allergy and Infectious Diseases,
   AI105779. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
NR 60
TC 1
Z9 1
U1 1
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2015
VL 10
IS 8
AR e0135340
DI 10.1371/journal.pone.0135340
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO4HF
UT WOS:000359121100154
PM 26252012
ER

PT J
AU Thomson, S
   Edin, ML
   Lih, FB
   Davies, M
   Yaqoob, MM
   Hammock, BD
   Gilroy, D
   Zeldin, DC
   Bishop-Bailey, D
AF Thomson, Scott
   Edin, Matthew L.
   Lih, Fred B.
   Davies, Michael
   Yaqoob, Muhammad M.
   Hammock, Bruce D.
   Gilroy, Derek
   Zeldin, Darryl C.
   Bishop-Bailey, David
TI Intimal smooth muscle cells are a source but not a sensor of
   anti-inflammatory CYP450 derived oxylipins
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Smooth muscle cell; LPS; Oxylipin; Epoxygenase; Soluble epoxide
   hydrolase
ID SOLUBLE EPOXIDE HYDROLASE; NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY;
   IN-VITRO; RAT AORTA; CYTOCHROME-P450; OMEGA-3-FATTY-ACIDS;
   HETEROGENEITY; EICOSANOIDS; METABOLISM
AB Vascular pathologies are associated with changes in the presence and expression of morphologically distinct vascular smooth muscle cells. In particular, in complex human vascular lesions and models of disease in pigs and rodents, an intimal smooth muscle cell (iSMC) which exhibits a stable epithelioid or rhomboid phenotype in culture is often found to be present in high numbers, and may represent the reemergence of a distinct developmental vascular smooth muscle cell phenotype. The CYP450-oxylipin - soluble epoxide hydrolase (sEH) pathway is currently of great interest in targeting for cardiovascular disease. sEH inhibitors limit the development of hypertension, diabetes, atherosclerosis and aneurysm formation in animal models. We have investigated the expression of CYP450-oxylipin-sEH pathway enzymes and their metabolites in paired intimal (iSMC) and medial (mSMC) cells isolated from rat aorta. iSMC basally released significantly larger amounts of epoxy-oxylipin CYP450 products from eicosapentaenoic acid > docosahexaenoic acid > arachidonic acid > linoleic acid, and expressed higher levels of CYP2C12, CYP2B1, but not CYP2J mRNA compared to mSMC. When stimulated with the proinflammatory TLR4 ligand LPS, epoxy-oxylipin production did not change greatly in iSMC. In contrast, LPS induced epoxy-oxylipin products in mSMC and induced CYP2J4. iSMC and mSMC express sEH which metabolizes primary epoxy-oxylipins to their dihydroxy-counterparts. The sEH inhibitors TPPU or AUDA inhibited LPS-induced NF kappa B activation and iNOS induction in mSMC, but had no effect on NF kappa B nuclear localization or inducible nitric oxide synthase in iSMC; effects which were recapitulated in part by addition of authentic epoxy-oxylipins. iSMCs are a rich source but not a sensor of anti-inflammatory epoxy-oxylipins. Complex lesions that contain high levels of iSMCs may be more resistant to the protective effects of sEH inhibitors. (C) 2015 The Authors. Published by Elsevier Inc.
C1 [Thomson, Scott; Davies, Michael; Bishop-Bailey, David] Univ London Royal Vet Coll, Comparat Biomed Sci, London NW1 0TU, England.
   [Edin, Matthew L.; Lih, Fred B.; Zeldin, Darryl C.] NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA.
   [Yaqoob, Muhammad M.] Queen Mary Univ, London EC1M 6BQ, England.
   [Hammock, Bruce D.] Univ Calif, Dept Entomol, Davies, CA 95616 USA.
   [Hammock, Bruce D.] Univ Calif, Ctr Comprehens Canc, Davies, CA 95616 USA.
   [Gilroy, Derek] UCL, London, England.
RP Bishop-Bailey, D (reprint author), Univ London Royal Vet Coll, Comparat Biomed Sci, Royal Coll St, London NW1 0TU, England.
EM dbishopbailey@rvc.ac.uk
OI Edin, Matthew/0000-0002-7042-500X
FU British Heart Foundation [PG/11/39/28890]; National Institutes of
   Health, National Institute of Environmental Health Sciences [Z01
   ES025034, R01 ES002710]
FX This work was supported by funding from the British Heart Foundation
   (PG/11/39/28890 to DBB and DWG), and in part, by funds from the
   Intramural Research Program of the National Institutes of Health,
   National Institute of Environmental Health Sciences Z01 ES025034 to DCZ
   and R01 ES002710 to BDH.
NR 42
TC 2
Z9 2
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 7
PY 2015
VL 463
IS 4
BP 774
EP 780
DI 10.1016/j.bbrc.2015.06.012
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CN5FN
UT WOS:000358455300049
PM 26086108
ER

PT J
AU Hou, Y
   Wu, K
   Shi, XL
   Li, FQ
   Song, LT
   Wu, HJ
   Dean, M
   Li, GB
   Tsang, S
   Jiang, RZ
   Zhang, XL
   Li, B
   Liu, G
   Bedekar, N
   Lu, N
   Xie, GY
   Liang, H
   Chang, L
   Wang, T
   Chen, JH
   Li, YR
   Zhang, XQ
   Yang, HM
   Xu, X
   Wang, L
   Wang, J
AF Hou, Yong
   Wu, Kui
   Shi, Xulian
   Li, Fuqiang
   Song, Luting
   Wu, Hanjie
   Dean, Michael
   Li, Guibo
   Tsang, Shirley
   Jiang, Runze
   Zhang, Xiaolong
   Li, Bo
   Liu, Geng
   Bedekar, Niharika
   Lu, Na
   Xie, Guoyun
   Liang, Han
   Chang, Liao
   Wang, Ting
   Chen, Jianghao
   Li, Yingrui
   Zhang, Xiuqing
   Yang, Huanming
   Xu, Xun
   Wang, Ling
   Wang, Jun
TI Comparison of variations detection between whole-genome amplification
   methods used in single-cell resequencing
SO GIGASCIENCE
LA English
DT Article
DE Whole genome amplification; Single-cell resequencing; Variations
   detection; DOP-PCR; MDA; MALBAC; Next-generation sequencing
ID MULTIPLE DISPLACEMENT AMPLIFICATION; STRUCTURAL VARIATION; SEQUENCING
   DATA; DNA; EVOLUTION; ALIGNMENT; MUTATION; RECOMBINATION; NUCLEOTIDE;
   TOOLKIT
AB Background: Single-cell resequencing (SCRS) provides many biomedical advances in variations detection at the single-cell level, but it currently relies on whole genome amplification (WGA). Three methods are commonly used for WGA: multiple displacement amplification (MDA), degenerate-oligonucleotide-primed PCR (DOP-PCR) and multiple annealing and looping-based amplification cycles (MALBAC). However, a comprehensive comparison of variations detection performance between these WGA methods has not yet been performed.
   Results: We systematically compared the advantages and disadvantages of different WGA methods, focusing particularly on variations detection. Low-coverage whole-genome sequencing revealed that DOP-PCR had the highest duplication ratio, but an even read distribution and the best reproducibility and accuracy for detection of copy-number variations (CNVs). However, MDA had significantly higher genome recovery sensitivity (similar to 84 %) than DOP-PCR (similar to 6 %) and MALBAC (similar to 52 %) at high sequencing depth. MALBAC and MDA had comparable single-nucleotide variations detection efficiency, false-positive ratio, and allele drop-out ratio. We further demonstrated that SCRS data amplified by either MDA or MALBAC from a gastric cancer cell line could accurately detect gastric cancer CNVs with comparable sensitivity and specificity, including amplifications of 12p11.22 (KRAS) and 9p24.1 (JAK2, CD274, and PDCD1LG2).
   Conclusions: Our findings provide a comprehensive comparison of variations detection performance using SCRS amplified by different WGA methods. It will guide researchers to determine which WGA method is best suited to individual experimental needs at single-cell level.
C1 [Hou, Yong; Wu, Kui; Shi, Xulian; Li, Fuqiang; Song, Luting; Wu, Hanjie; Li, Guibo; Jiang, Runze; Zhang, Xiaolong; Li, Bo; Liu, Geng; Lu, Na; Xie, Guoyun; Liang, Han; Chang, Liao; Li, Yingrui; Yang, Huanming; Xu, Xun; Wang, Jun] BGI Shenzhen, Shenzhen 518083, Peoples R China.
   [Shi, Xulian; Lu, Na] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.
   [Dean, Michael] NCI, Canc & Inflammat Program, Frederick, MD 21702 USA.
   [Tsang, Shirley] BioMatrix LLC, Rockville, MD 20850 USA.
   [Zhang, Xiaolong] Univ Chinese Acad Sci Coll, Coll Life Sci, Beijing 100049, Peoples R China.
   [Bedekar, Niharika] Stanford Univ, Stanford, CA 94305 USA.
   [Wang, Ting; Chen, Jianghao; Wang, Ling] Fourth Mil Med Univ, Xijing Hosp, Dept Vasc & Endocrine Surg, Xian 710032, Peoples R China.
   [Zhang, Xiuqing] BGI Shenzhen, Guangdong Enterprise Key Lab Human Dis Genom, Shenzhen 518083, Peoples R China.
   [Yang, Huanming; Wang, Jun] King Abdulaziz Univ, Princess Al Jawhara Ctr Excellence Res Hereditary, Jeddah 21589, Saudi Arabia.
   [Yang, Huanming] Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wang, Jun] Univ Copenhagen, Dept Biol, DK-1599 Copenhagen, Denmark.
   [Wang, Jun] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, DK-1599 Copenhagen, Denmark.
RP Xu, X (reprint author), BGI Shenzhen, Shenzhen 518083, Peoples R China.
EM xuxun@genomics.cn; vascular@fmmu.edu.cn; wangj@genomics.cn
RI Li, Yingrui/K-1064-2015; Wang, Jun/C-8434-2016; Wang, Jun/B-9503-2016; 
OI Wang, Jun/0000-0002-8540-8931; Wang, Jun/0000-0002-2113-5874; hou,
   yong/0000-0002-0420-0726
FU National High Technology Research and Development Program of China - 863
   Program [2012AA02A201]; Guangdong Innovative Research Team Program
   [2009010016]; Guangdong Enterprise Key Laboratory of Human Disease
   Genomics [2011A060906007]; National Basic Research Program of China (973
   program) [2011CB809202, 2011CB809203]; Major Industrial Technology
   Research Program of Shenzhen [BGI20100001]; Shenzhen City
   [CXB201108250096A, ZDSYS20140509153457495]; Shenzhen Key Laboratory of
   China National GeneBank-Shenzhen; National Natural Science Fund
   [81272899, 81172510]; Discipline booster plan of Xi Jing Hospital
   [XJZT12Z07]; Danish Natural Science Research Council; Danish National
   Research Foundation; National Natural Science Foundation of China;
   Shenzhen Municipal Government; Local Government of Yantian District of
   Shenzhen
FX We thank L Goodman for revising the manuscript and Youyong Lv for
   providing the BGC823 gastric cancer cell line. This work was supported
   by the National High Technology Research and Development Program of
   China - 863 Program (NO. 2012AA02A201), the Guangdong Innovative
   Research Team Program (2009010016), the Guangdong Enterprise Key
   Laboratory of Human Disease Genomics (No. 2011A060906007), National
   Basic Research Program of China (973 program No. 2011CB809202 and
   2011CB809203), the Major Industrial Technology Research Program of
   Shenzhen (program number BGI20100001), the Key Laboratory Project
   Supported by Shenzhen City (grants CXB201108250096A and
   ZDSYS20140509153457495) and the Shenzhen Key Laboratory of China
   National GeneBank-Shenzhen. This project was also supported by the
   National Natural Science Fund (81272899 and 81172510) and Discipline
   booster plan of Xi Jing Hospital (XJZT12Z07). We also acknowledge the
   Ole Romer grant from the Danish Natural Science Research Council, the
   Danish National Research Foundation, National Natural Science Foundation
   of China, and funds from the Shenzhen Municipal Government and the Local
   Government of Yantian District of Shenzhen.
NR 40
TC 9
Z9 12
U1 5
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2047-217X
J9 GIGASCIENCE
JI GigaScience
PD AUG 6
PY 2015
VL 4
AR 37
DI 10.1186/s13742-015-0068-3
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CX4JV
UT WOS:000365667100001
PM 26251698
ER

PT J
AU Llacer, JL
   Hussain, T
   Marler, L
   Aitken, CE
   Thakur, A
   Lorsch, JR
   Hinnebusch, AG
   Ramakrishnan, V
AF Llacer, Jose L.
   Hussain, Tanweer
   Marler, Laura
   Aitken, Colin Echeverria
   Thakur, Anil
   Lorsch, Jon R.
   Hinnebusch, Alan G.
   Ramakrishnan, V.
TI Conformational Differences between Open and Closed States of the
   Eukaryotic Translation Initiation Complex
SO MOLECULAR CELL
LA English
DT Article
ID 40S RIBOSOMAL-SUBUNIT; START-SITE SELECTION; EM STRUCTURE DETERMINATION;
   RNA RECOGNITION MOTIF; PREINITIATION COMPLEX; MESSENGER-RNA;
   CRYSTAL-STRUCTURE; IN-VIVO; ELECTRON CRYOMICROSCOPY; MULTIFACTOR COMPLEX
AB Translation initiation in eukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal subunit, eIF1, eIF1A, eIF3, ternary complex (eIF2-GTP-Met-tRNA(i)), and eIF5. The PIC, in an open conformation, attaches to the 5' end of the mRNA and scans to locate the start codon, whereupon it closes to arrest scanning. We present single particle cryo-electron microscopy (cryo-EM) reconstructions of 48S PICs from yeast in these open and closed states, at 6.0 angstrom and 4.9 angstrom, respectively. These reconstructions show eIF2 beta as well as a configuration of eIF3 that appears to encircle the 40S, occupying part of the subunit interface. Comparison of the complexes reveals a large conformational change in the 40S head from an open mRNA latch conformation to a closed one that constricts the mRNA entry channel and narrows the P site to enclose tRNA(i), thus elucidating key events in start codon recognition.
C1 [Llacer, Jose L.; Hussain, Tanweer; Ramakrishnan, V.] MRC, Mol Biol Lab, Cambridge CB2 0QH, England.
   [Marler, Laura; Thakur, Anil; Hinnebusch, Alan G.] Eunice K Shriver Natl Inst Child Hlth & Human Dev, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA.
   [Aitken, Colin Echeverria; Lorsch, Jon R.] Eunice K Shriver Natl Inst Child Hlth & Human Dev, Lab Mech & Regulat Prot Synth, NIH, Bethesda, MD 20892 USA.
RP Ramakrishnan, V (reprint author), MRC, Mol Biol Lab, Cambridge CB2 0QH, England.
EM ramak@mrc-lmb.cam.ac.uk
OI Lorsch, Jon/0000-0002-4521-4999; Ramakrishnan, V/0000-0002-4699-2194
FU FEBS; EMBO; UK Medical Research Council [MC_U105184332]; Wellcome Trust
   [WT096570]; Agouron Institute; Jeantet Foundation; NIH [GM62128]; Human
   Frontiers in Science Program [RGP-0028/2009]; Intramural Research
   Program of the NIH
FX We are grateful to S. Chen, C.G. Savva, K.R. Vinothkumar, G. McMullan,
   and the staff of FEI for technical support with cryo-EM; T. Darling and
   J. Grimmett for help with computing; X.C. Bai and S.H.W. Scheres for
   advice with EM data processing; and G. Murshudov for help with
   refinement of the atomic coordinates. We also thank A. Kelley and I.S.
   Fernandez for providing reagents. J.L.L. and T.H. were, respectively,
   supported by postdoctoral fellowships from FEBS and EMBO. This work was
   funded by grants to from the UK Medical Research Council
   (MC_U105184332), Wellcome Trust Senior Investigator award (WT096570),
   the Agouron Institute and the Jeantet Foundation to V.R.; from the NIH
   (GM62128) formerly to J.R.L.; the Human Frontiers in Science Program
   (RGP-0028/2009) to A.G.H., J.R.L., and V.R.; and by the Intramural
   Research Program of the NIH (A.G.H., J.R.L., and C.E.A.).
NR 54
TC 25
Z9 25
U1 1
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
EI 1097-4164
J9 MOL CELL
JI Mol. Cell
PD AUG 6
PY 2015
VL 59
IS 3
BP 399
EP 412
DI 10.1016/j.molcel.2015.06.033
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CT0BB
UT WOS:000362457600007
PM 26212456
ER

PT J
AU Somannavar, MS
   Goudar, SS
   Revankar, AP
   Moore, JL
   McClure, EM
   Destefanis, P
   DeCain, M
   Goco, N
   Wright, LL
AF Somannavar, Manjunath S.
   Goudar, Shivaprasad S.
   Revankar, Amit P.
   Moore, Janet L.
   McClure, Elizabeth M.
   Destefanis, Pablo
   DeCain, Martha
   Goco, Norman
   Wright, Linda L.
TI Evaluating time between birth to cry or bag and mask ventilation using
   mobile delivery room timers in India: the NICHD Global Network's Helping
   Babies Breathe Trial
SO BMC PEDIATRICS
LA English
DT Article
DE Resuscitation; Golden minute; Asphyxia; India; Helping babies breathe
ID NEONATAL RESUSCITATION; NEWBORN MORTALITY; STILLBIRTH; TANZANIA
AB Background: The Golden Minute (R), the first minute following birth of a newborn, is a critical period for establishing ventilation after delivery, as emphasized in the Helping Babies Breather and other resuscitation training programs. Previous studies have reinforced training through observers' evaluation of this time period; although observation is useful for research, it may not be a sustainable method to support resuscitation practice in low-resource settings where few birth attendants are available. In order to reinforce resuscitation within The Golden Minute (R), we sought to develop a simple mobile delivery-room timer on an Android cell phone platform for birth attendants to use at the time of delivery.
   Methods: We developed and evaluated a mobile delivery room timer to document the time interval from birth to the initiation of newborn crying/spontaneous respiration or bag and mask ventilation in a convenience sample of women who delivered in five hospitals in Karnataka, India. The mobile delivery room timer is an Android cell phone-based application that recorded key events including crowning, delivery, and crying/spontaneous respiration or bag and mask ventilation. The mobile delivery room timer recorded the birth attendant verbally indicating the time of crowning, birth-(defined as when the entire baby was delivered), crying/spontaneous respiration or bag and mask ventilation. The mobile delivery room timer results were validated in a subsample by a trained observer (nurse) who independently recorded the time between delivery and initiation of crying/spontaneous respiration or bag and mask ventilation.
   Results: Of the total 4,597 deliveries, 2,107 (46 %) were timed; a sample (n = 438) of these deliveries was also observed by a trained nurse. There was high concordance between the mobile delivery room timer and observed time elapsed between birth and crying/spontaneous respiration or ventilation (correlation = 0.94, p < 0.0001). The majority of neonates in both groups cried/breathed spontaneously or received bag and mask ventilation by 1 min (430/438 by the timer vs. 433/438 for observer).
   Conclusions: We demonstrated that a simple mobile delivery room timer application was feasible to use during delivery and provided valid observations of the time to crying/spontaneous respiration or bag and mask ventilation. This type of tool may be useful in reinforcing neonatal resuscitation training and the need to ensure spontaneous or assisted ventilation by The Golden Minute (R).
C1 [Somannavar, Manjunath S.; Goudar, Shivaprasad S.; Revankar, Amit P.] KLE Univ Jawaharlal Nehru Med Coll, Belgaum, Karnataka, India.
   [Moore, Janet L.; McClure, Elizabeth M.; Destefanis, Pablo; DeCain, Martha; Goco, Norman] RTI Int, Durham, NC USA.
   [Wright, Linda L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
RP Somannavar, MS (reprint author), KLE Univ Jawaharlal Nehru Med Coll, Belgaum, Karnataka, India.
EM manjunathsomannavar@gmail.com
OI Somannavar, Manjunath/0000-0002-8871-5072
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development; Norwegian Agency for Development Cooperation (Norad);
   Laerdal Foundation [U01HD042372, U01HD40636]
FX This study was funded by grants from The Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, The Norwegian Agency
   for Development Cooperation (Norad), and the Laerdal Foundation (grant
   numbers U01HD042372, U01HD40636).
NR 13
TC 0
Z9 0
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD AUG 6
PY 2015
VL 15
AR 93
DI 10.1186/s12887-015-0408-6
PG 9
WC Pediatrics
SC Pediatrics
GA CO2JC
UT WOS:000358981100001
PM 26245688
ER

PT J
AU Khamsy, L
   Constanthin, PE
   Sadowski, SM
   Triponez, F
AF Khamsy, Lilly
   Constanthin, Paul E.
   Sadowski, Samira M.
   Triponez, Frederic
TI Loss of neuromonitoring signal during bilateral thyroidectomy: no
   systematic change in operative strategy according to a survey of the
   French Association of Endocrine Surgeons (AFCE)
SO BMC SURGERY
LA English
DT Article
DE Intraoperative neuromonitoring; Bilateral thyroidectomy; Recurrent
   laryngeal nerve injury
ID RECURRENT LARYNGEAL NERVE; PARATHYROID SURGERY; RISK-FACTORS; INJURY;
   PARALYSIS; OUTCOMES
AB Background: Total thyroidectomy presents a risk of bilateral vocal cord paralysis, which can lead to compromised airway. Visual Recurrent Laryngeal Nerve (RLN) identification significantly decreases this risk of RLN lesion. Yet, an anatomically intact nerve is not always functional. Intraoperative neuromonitoring (IONM) allows to test in real time the function of the RLN. In case of loss of signal (LOS) on the first operated side, some authors recommend to stop the intervention. The purpose of this study was to characterize the operative strategy of the French-speaking surgeons in case of LOS on the first side in planned bilateral thyroidectomies.
   Methods: An online questionnaire was sent to the surgeons of the French Association of Endocrine Surgeons (AFCE).
   Results: We collected 69 responses (response rate: 42 %). Forty-six surgeons (66 %) used IONM. After a signal loss, 22 % (N = 10) stopped the operation in all cases, 24 % (N = 11) continued the operation in case of malignant disease and stopped in cases of benign disease, and 54 % (N = 25) continued the operation contralaterally.
   Conclusions: The majority of surgeons continued the operation contralaterally as originally planned despite a loss of IONM signal at the end of the first side.
C1 [Khamsy, Lilly; Constanthin, Paul E.; Triponez, Frederic] Univ Geneva, Fac Med, Geneva, Switzerland.
   [Khamsy, Lilly; Constanthin, Paul E.; Sadowski, Samira M.; Triponez, Frederic] Univ Hosp Geneva, Thorac & Endocrine Surg, Geneva, Switzerland.
   [Sadowski, Samira M.] NCI, Endocrine Oncol Branch, NIH, Bethesda, MD 20892 USA.
RP Triponez, F (reprint author), Univ Geneva, Fac Med, Geneva, Switzerland.
EM Frederic.triponez@hcuge.ch
NR 25
TC 0
Z9 0
U1 1
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD AUG 6
PY 2015
VL 15
AR 95
DI 10.1186/s12893-015-0082-5
PG 6
WC Surgery
SC Surgery
GA CO2LK
UT WOS:000358987500001
PM 26245329
ER

PT J
AU Vella, S
   Pomella, S
   Leoncini, PP
   Colletti, M
   Conti, B
   Marquez, VE
   Strillacci, A
   Roma, J
   Gallego, S
   Milano, GM
   Capogrossi, MC
   Bertaina, A
   Ciarapica, R
   Rota, R
AF Vella, Serena
   Pomella, Silvia
   Leoncini, Pier Paolo
   Colletti, Marta
   Conti, Beatrice
   Marquez, Victor E.
   Strillacci, Antonio
   Roma, Josep
   Gallego, Soledad
   Milano, Giuseppe M.
   Capogrossi, Maurizio C.
   Bertaina, Alice
   Ciarapica, Roberta
   Rota, Rossella
TI MicroRNA-101 is repressed by EZH2 and its restoration inhibits
   tumorigenic features in embryonal rhabdomyosarcoma
SO CLINICAL EPIGENETICS
LA English
DT Article
DE MiR-101; EZH2; Histone methyltransferases; Polycomb proteins;
   Rhabdomyosarcoma; Cell motility; Cell proliferation;
   Anchorage-independent growth; Chromatin immunoprecipitation
ID HUMAN HEPATOCELLULAR-CARCINOMA; ZESTE HOMOLOG 2; CANCER-CELLS;
   TUMOR-SUPPRESSOR; DOWN-REGULATION; PROTEIN EZH2; ALVEOLAR
   RHABDOMYOSARCOMA; MYOGENIC DIFFERENTIATION; SKELETAL-MUSCLE;
   GENE-EXPRESSION
AB Background: Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 histone H3 methyltransferase that regulates the balance between cell proliferation and differentiation by epigenetically silencing muscle-specific genes. EZH2 is often over-expressed in several human cancers acting as an oncogene. We previously reported that EZH2 inhibition induces cell cycle arrest followed by myogenic differentiation of RMS cells of the embryonal subtype (eRMS). MiR-101 is a microRNA involved in a negative feedback circuit with EZH2 in different normal and tumor tissues. To that, miR-101 can behave as a tumor suppressor in several cancers by repressing EZH2 expression. We, therefore, evaluated whether miR-101 is de-regulated in eRMS and investigated its interplaying with EZH2 as well as its role in the in vitro tumorigenic potential of these tumor cells.
   Results: Herein, we report that miR-101 is down-regulated in eRMS patients and in tumor cell lines compared to their controls showing an inverse pattern of expression with EZH2. We also show that miR-101 is up-regulated in eRMS cells following both genetic and pharmacological inhibition of EZH2. In turn, miR-101 forced expression reduces EZH2 levels as well as restrains the migratory potential of eRMS cells and impairs their clonogenic and anchorage-independent growth capabilities. Finally, EZH2 recruitment to regulatory region of miR-101-2 gene decreases in EZH2-silenced eRMS cells. This phenomenon is associated to reduced H3K27me3 levels at the same regulatory locus, indicating that EZH2 directly targets miR-101 for repression in eRMS cells.
   Conclusions: Altogether, our data show that, in human eRMS, miR-101 is involved in a negative feedback loop with EZH2, whose targeting has been previously shown to halt eRMS tumorigenicity. They also demonstrate that the re-induction of miR-101 hampers the tumor features of eRMS cells. In this scenario, epigenetic dysregulations confirm their crucial role in the pathogenesis of this soft tissue sarcoma.
C1 [Vella, Serena; Leoncini, Pier Paolo; Colletti, Marta; Conti, Beatrice; Rota, Rossella] Osped Pediat Bambino Gesu, Dept Oncohematol, Lab Angiogenesis, IRCCS, I-00165 Rome, Italy.
   [Pomella, Silvia; Capogrossi, Maurizio C.; Ciarapica, Roberta] IRCCS, Ist Dermopat Immacolata, Lab Patol Vasc, Rome, Italy.
   [Marquez, Victor E.] NCI, Biol Chem Lab, Frederick Natl Lab Canc Res, CCR,NIH, Frederick, MD 21701 USA.
   [Strillacci, Antonio] Univ Bologna, Biol Unit, Dept Biol Geol & Environm Sci, Bologna, Italy.
   [Roma, Josep; Gallego, Soledad] Univ Autonoma Barcelona, Vall Hebron Res Inst, Lab Translat Res Paediat Canc, E-08193 Barcelona, Spain.
   [Roma, Josep; Gallego, Soledad] Univ Autonoma Barcelona, Vall Hebron Hosp, E-08193 Barcelona, Spain.
   [Milano, Giuseppe M.; Bertaina, Alice] Osped Pediat Bambino Gesu, IRCCS, Clin Unit, Dept Oncohematol, I-00165 Rome, Italy.
RP Rota, R (reprint author), Osped Pediat Bambino Gesu, Dept Oncohematol, Lab Angiogenesis, IRCCS, Piazza S Onofrio 4, I-00165 Rome, Italy.
EM alice.bertaina@opbg.net; roberta.ciarapica@yahoo.com;
   rossella.rota@opbg.net
RI Vella, Serena/K-6451-2016; Colletti, Marta/K-6926-2016; 
OI Gallego, Soledad/0000-0002-4712-9624; Vella, Serena/0000-0001-9477-9294;
   Colletti, Marta/0000-0002-9433-4903; Rota, Rossella/0000-0002-9408-7711;
   Leoncini, Pier Paolo/0000-0002-1708-7291; Roma,
   Josep/0000-0001-7692-6123
FU NIH Intramural Research Program, National Cancer Institute, CCR; Italian
   Ministry of Health Ricerca Corrente; Associazione Italiana per la
   Ricerca sul Cancro (AIRC)
FX This work was supported by grants from the NIH Intramural Research
   Program, National Cancer Institute, CCR (to VEM); Italian Ministry of
   Health Ricerca Corrente (to MCC and AB); and Associazione Italiana per
   la Ricerca sul Cancro (AIRC) and Italian Ministry of Health Ricerca
   Corrente (to RR).
NR 37
TC 7
Z9 9
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD AUG 6
PY 2015
VL 7
AR 82
DI 10.1186/s13148-015-0107-z
PG 13
WC Oncology
SC Oncology
GA CO4BI
UT WOS:000359104600001
PM 26251675
ER

PT J
AU Carroll, MW
   Matthews, DA
   Hiscox, JA
   Elmore, MJ
   Pollakis, G
   Rambaut, A
   Hewson, R
   Garcia-Dorival, I
   Bore, JA
   Koundouno, R
   Abdellati, S
   Afrough, B
   Aiyepada, J
   Akhilomen, P
   Asogun, D
   Atkinson, B
   Badusche, M
   Bah, A
   Bate, S
   Baumann, J
   Becker, D
   Becker-Ziaja, B
   Bocquin, A
   Borremans, B
   Bosworth, A
   Boettcher, JP
   Cannas, A
   Carletti, F
   Castilletti, C
   Clark, S
   Colavita, F
   Diederich, S
   Donatus, A
   Duraffour, S
   Ehichioya, D
   Ellerbrok, H
   Fernandez-Garcia, MD
   Fizet, A
   Fleischmann, E
   Gryseels, S
   Hermelink, A
   Hinzmann, J
   Hopf-Guevara, U
   Ighodalo, Y
   Jameson, L
   Kelterbaum, A
   Kis, Z
   Kloth, S
   Kohl, C
   Korva, M
   Kraus, A
   Kuisma, E
   Kurth, A
   Liedigk, B
   Logue, CH
   Ludtke, A
   Maes, P
   McCowen, J
   Mely, S
   Mertens, M
   Meschi, S
   Meyer, B
   Michel, J
   Molkenthin, P
   Munoz-Fontela, C
   Muth, D
   Newman, ENC
   Ngabo, D
   Oestereich, L
   Okosun, J
   Olokor, T
   Omiunu, R
   Omomoh, E
   Pallasch, E
   Palyi, B
   Portmann, J
   Pottage, T
   Pratt, C
   Priesnitz, S
   Quartu, S
   Rappe, J
   Repits, J
   Richter, M
   Rudolf, M
   Sachse, A
   Schmidt, KM
   Schudt, G
   Strecker, T
   Thom, R
   Thomas, S
   Tobin, E
   Tolley, H
   Trautner, J
   Vermoesen, T
   Vitoriano, I
   Wagner, M
   Wolff, S
   Yue, C
   Capobianchi, MR
   Kretschmer, B
   Hall, Y
   Kenny, JG
   Rickett, NY
   Dudas, G
   Coltart, CEM
   Kerber, R
   Steer, D
   Wright, C
   Senyah, F
   Keita, S
   Drury, P
   Diallo, B
   de Clerck, H
   Van Herp, M
   Sprecher, A
   Traore, A
   Diakite, M
   Konde, MK
   Koivogui, L
   Magassouba, N
   Avsic-Zupanc, T
   Nitsche, A
   Strasser, M
   Ippolito, G
   Becker, S
   Stoecker, K
   Gabriel, M
   Raoul, H
   Di Caro, A
   Wolfel, R
   Formenty, P
   Gunther, S
AF Carroll, Miles W.
   Matthews, David A.
   Hiscox, Julian A.
   Elmore, Michael J.
   Pollakis, Georgios
   Rambaut, Andrew
   Hewson, Roger
   Garcia-Dorival, Isabel
   Bore, Joseph Akoi
   Koundouno, Raymond
   Abdellati, Said
   Afrough, Babak
   Aiyepada, John
   Akhilomen, Patience
   Asogun, Danny
   Atkinson, Barry
   Badusche, Marlis
   Bah, Amadou
   Bate, Simon
   Baumann, Jan
   Becker, Dirk
   Becker-Ziaja, Beate
   Bocquin, Anne
   Borremans, Benny
   Bosworth, Andrew
   Boettcher, Jan Peter
   Cannas, Angela
   Carletti, Fabrizio
   Castilletti, Concetta
   Clark, Simon
   Colavita, Francesca
   Diederich, Sandra
   Donatus, Adomeh
   Duraffour, Sophie
   Ehichioya, Deborah
   Ellerbrok, Heinz
   Fernandez-Garcia, Maria Dolores
   Fizet, Alexandra
   Fleischmann, Erna
   Gryseels, Sophie
   Hermelink, Antje
   Hinzmann, Julia
   Hopf-Guevara, Ute
   Ighodalo, Yemisi
   Jameson, Lisa
   Kelterbaum, Anne
   Kis, Zoltan
   Kloth, Stefan
   Kohl, Claudia
   Korva, Misa
   Kraus, Annette
   Kuisma, Eeva
   Kurth, Andreas
   Liedigk, Britta
   Logue, Christopher H.
   Luedtke, Anja
   Maes, Piet
   McCowen, James
   Mely, Stephane
   Mertens, Marc
   Meschi, Silvia
   Meyer, Benjamin
   Michel, Janine
   Molkenthin, Peter
   Munoz-Fontela, Cesar
   Muth, Doreen
   Newman, Edmund N. C.
   Ngabo, Didier
   Oestereich, Lisa
   Okosun, Jennifer
   Olokor, Thomas
   Omiunu, Racheal
   Omomoh, Emmanuel
   Pallasch, Elisa
   Palyi, Bernadett
   Portmann, Jasmine
   Pottage, Thomas
   Pratt, Catherine
   Priesnitz, Simone
   Quartu, Serena
   Rappe, Julie
   Repits, Johanna
   Richter, Martin
   Rudolf, Martin
   Sachse, Andreas
   Schmidt, Kristina Maria
   Schudt, Gordian
   Strecker, Thomas
   Thom, Ruth
   Thomas, Stephen
   Tobin, Ekaete
   Tolley, Howard
   Trautner, Jochen
   Vermoesen, Tine
   Vitoriano, Ines
   Wagner, Matthias
   Wolff, Svenja
   Yue, Constanze
   Capobianchi, Maria Rosaria
   Kretschmer, Birte
   Hall, Yper
   Kenny, John G.
   Rickett, Natasha Y.
   Dudas, Gytis
   Coltart, Cordelia E. M.
   Kerber, Romy
   Steer, Damien
   Wright, Callum
   Senyah, Francis
   Keita, Sakoba
   Drury, Patrick
   Diallo, Boubacar
   de Clerck, Hilde
   Van Herp, Michel
   Sprecher, Armand
   Traore, Alexis
   Diakite, Mandiou
   Konde, Mandy Kader
   Koivogui, Lamine
   Magassouba, N'Faly
   Avsic-Zupanc, Tatjana
   Nitsche, Andreas
   Strasser, Marc
   Ippolito, Giuseppe
   Becker, Stephan
   Stoecker, Kilian
   Gabriel, Martin
   Raoul, Herve
   Di Caro, Antonino
   Woelfel, Roman
   Formenty, Pierre
   Guenther, Stephan
TI Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in
   West Africa
SO NATURE
LA English
DT Article
ID INFERENCE; MODEL; VP24
AB West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded(1-3). Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref. 2). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak.
C1 [Carroll, Miles W.; Elmore, Michael J.; Hewson, Roger; Afrough, Babak; Atkinson, Barry; Bate, Simon; Bosworth, Andrew; Clark, Simon; Jameson, Lisa; Kuisma, Eeva; Logue, Christopher H.; McCowen, James; Newman, Edmund N. C.; Ngabo, Didier; Pottage, Thomas; Pratt, Catherine; Thom, Ruth; Thomas, Stephen; Tolley, Howard; Vitoriano, Ines; Hall, Yper; Senyah, Francis] Publ Hlth England, Porton Down SP4 0JG, Wilts, England.
   [Carroll, Miles W.; Hewson, Roger; Bore, Joseph Akoi; Koundouno, Raymond; Abdellati, Said; Afrough, Babak; Aiyepada, John; Akhilomen, Patience; Asogun, Danny; Atkinson, Barry; Badusche, Marlis; Bah, Amadou; Bate, Simon; Baumann, Jan; Becker, Dirk; Becker-Ziaja, Beate; Bocquin, Anne; Borremans, Benny; Bosworth, Andrew; Boettcher, Jan Peter; Cannas, Angela; Carletti, Fabrizio; Castilletti, Concetta; Clark, Simon; Colavita, Francesca; Diederich, Sandra; Donatus, Adomeh; Duraffour, Sophie; Ehichioya, Deborah; Ellerbrok, Heinz; Fernandez-Garcia, Maria Dolores; Fizet, Alexandra; Fleischmann, Erna; Gryseels, Sophie; Hermelink, Antje; Hinzmann, Julia; Hopf-Guevara, Ute; Ighodalo, Yemisi; Jameson, Lisa; Kelterbaum, Anne; Kis, Zoltan; Kloth, Stefan; Kohl, Claudia; Korva, Misa; Kraus, Annette; Kuisma, Eeva; Kurth, Andreas; Liedigk, Britta; Logue, Christopher H.; Luedtke, Anja; Maes, Piet; McCowen, James; Mely, Stephane; Mertens, Marc; Meschi, Silvia; Meyer, Benjamin; Michel, Janine; Molkenthin, Peter; Munoz-Fontela, Cesar; Muth, Doreen; Newman, Edmund N. C.; Ngabo, Didier; Oestereich, Lisa; Okosun, Jennifer; Olokor, Thomas; Omiunu, Racheal; Omomoh, Emmanuel; Pallasch, Elisa; Palyi, Bernadett; Portmann, Jasmine; Pottage, Thomas; Pratt, Catherine; Priesnitz, Simone; Quartu, Serena; Rappe, Julie; Repits, Johanna; Richter, Martin; Rudolf, Martin; Sachse, Andreas; Schmidt, Kristina Maria; Schudt, Gordian; Strecker, Thomas; Thom, Ruth; Thomas, Stephen; Tobin, Ekaete; Tolley, Howard; Trautner, Jochen; Vermoesen, Tine; Vitoriano, Ines; Wagner, Matthias; Wolff, Svenja; Yue, Constanze; Capobianchi, Maria Rosaria; Kerber, Romy; Avsic-Zupanc, Tatjana; Nitsche, Andreas; Strasser, Marc; Ippolito, Giuseppe; Becker, Stephan; Stoecker, Kilian; Gabriel, Martin; Raoul, Herve; Di Caro, Antonino; Woelfel, Roman; Guenther, Stephan] Bernhard Nocht Inst Trop Med, European Mobile Lab Consortium, D-20359 Hamburg, Germany.
   [Carroll, Miles W.] Univ Southampton, South Gen Hosp, Southampton SO16 6YD, Hants, England.
   [Matthews, David A.] Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England.
   [Hiscox, Julian A.; Pollakis, Georgios; Garcia-Dorival, Isabel; Bosworth, Andrew; Rickett, Natasha Y.] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 2BE, Merseyside, England.
   [Rambaut, Andrew; Dudas, Gytis] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 2FL, Midlothian, Scotland.
   [Rambaut, Andrew] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Rambaut, Andrew] Univ Edinburgh, Ctr Immunol Infect & Evolut, Edinburgh EH9 2FL, Midlothian, Scotland.
   [Hewson, Roger] London Sch Hyg & Trop Med, London WC1E 7HT, England.
   [Bore, Joseph Akoi; Koundouno, Raymond; Magassouba, N'Faly] Univ Gamal Abdel Nasser Conakry, Lab Fievres Hemorrag Guinee, Conakry, Guinea.
   [Bore, Joseph Akoi; Koundouno, Raymond; Koivogui, Lamine] Inst Nacl Sante Publ, Conakry, Guinea.
   [Abdellati, Said; Vermoesen, Tine] Inst Trop Med, B-2000 Antwerp, Belgium.
   [Aiyepada, John; Akhilomen, Patience; Asogun, Danny; Donatus, Adomeh; Ighodalo, Yemisi; Okosun, Jennifer; Olokor, Thomas; Omiunu, Racheal; Omomoh, Emmanuel; Tobin, Ekaete] Irrua Specialist Teaching Hosp, Inst Lassa Fever Res & Control, Irrua, Edo State, Nigeria.
   [Badusche, Marlis; Baumann, Jan; Becker-Ziaja, Beate; Duraffour, Sophie; Ehichioya, Deborah; Liedigk, Britta; Oestereich, Lisa; Pallasch, Elisa; Rudolf, Martin; Kerber, Romy; Gabriel, Martin; Guenther, Stephan] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany.
   [Badusche, Marlis; Becker, Dirk; Becker-Ziaja, Beate; Diederich, Sandra; Fleischmann, Erna; Kelterbaum, Anne; Liedigk, Britta; Luedtke, Anja; Mertens, Marc; Meyer, Benjamin; Molkenthin, Peter; Munoz-Fontela, Cesar; Muth, Doreen; Oestereich, Lisa; Pallasch, Elisa; Rudolf, Martin; Schudt, Gordian; Strecker, Thomas; Wagner, Matthias; Wolff, Svenja; Kerber, Romy; Becker, Stephan; Stoecker, Kilian; Gabriel, Martin; Woelfel, Roman; Guenther, Stephan] German Ctr Infect Res DZIF, D-38124 Braunschweig, Germany.
   [Bah, Amadou] Univ Basel, Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland.
   [Becker, Dirk; Kelterbaum, Anne; Schudt, Gordian; Strecker, Thomas; Wolff, Svenja; Becker, Stephan] Philipps Univ Marburg, Inst Virol, D-35043 Marburg, Germany.
   [Bocquin, Anne; Fizet, Alexandra; Mely, Stephane] Natl Reference Ctr Viral Hemorrhag Fevers, F-69365 Lyon, France.
   [Bocquin, Anne; Mely, Stephane; Raoul, Herve] US003 Inserm, Inserm Jean Merieux, Lab P4, F-69365 Lyon, France.
   [Borremans, Benny; Gryseels, Sophie] Univ Antwerp, Dept Biol, B-2020 Antwerp, Belgium.
   [Boettcher, Jan Peter; Ellerbrok, Heinz; Hermelink, Antje; Hinzmann, Julia; Hopf-Guevara, Ute; Kloth, Stefan; Kohl, Claudia; Kurth, Andreas; Michel, Janine; Richter, Martin; Sachse, Andreas; Schmidt, Kristina Maria; Yue, Constanze; Nitsche, Andreas] Robert Koch Inst, D-13353 Berlin, Germany.
   [Cannas, Angela; Carletti, Fabrizio; Castilletti, Concetta; Colavita, Francesca; Meschi, Silvia; Quartu, Serena; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Di Caro, Antonino] Natl Inst Infect Dis INMI Lazzaro Spallanzani, I-00149 Rome, Italy.
   [Diederich, Sandra; Mertens, Marc] Fed Res Inst Anim Hlth, Friedrich Loeffler Inst, D-17493 Greifswald, Insel Riems, Germany.
   [Duraffour, Sophie; Maes, Piet] Katholieke Univ Leuven, Rega Inst, B-3000 Leuven, Belgium.
   [Ehichioya, Deborah] Redeemers Univ, Mowe, Osun State, Nigeria.
   [Fernandez-Garcia, Maria Dolores] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid 28029, Spain.
   [Fizet, Alexandra] Inst Pasteur, Unite Biol Infect Virales Emergentes, F-69365 Lyon, France.
   [Fleischmann, Erna; Molkenthin, Peter; Wagner, Matthias; Stoecker, Kilian; Woelfel, Roman] Bundeswehr Inst Microbiol, D-80937 Munich, Germany.
   [Kis, Zoltan; Palyi, Bernadett] Natl Ctr Epidemiol, Natl Biosafety Lab, H-1097 Budapest, Hungary.
   [Korva, Misa; Avsic-Zupanc, Tatjana] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, SI-1000 Ljubljana, Slovenia.
   [Kraus, Annette] Publ Hlth Agcy Sweden, S-17182 Solna, Sweden.
   [Luedtke, Anja; Munoz-Fontela, Cesar] Leibniz Inst Expt Virol, Heinrich Pette Inst, D-20251 Hamburg, Germany.
   [Meyer, Benjamin; Muth, Doreen] Univ Bonn, Inst Virol, D-53127 Bonn, Germany.
   [Portmann, Jasmine; Strasser, Marc] Fed Off Civil Protect, Spiez Lab, CH-3700 Spiez, Switzerland.
   [Priesnitz, Simone] Bundeswehr Hosp, D-22049 Hamburg, Germany.
   [Rappe, Julie] Inst Virol & Immunol, CH-3147 Mittelhausern, Switzerland.
   [Repits, Johanna] Janssen Cilag, SE-19207 Sollentuna, Sweden.
   [Trautner, Jochen] Thunen Inst, D-22767 Hamburg, Germany.
   [Kretschmer, Birte] Eurice European Res & Project Off GmbH, D-10115 Berlin, Germany.
   [Kenny, John G.] Univ Liverpool, Inst Integrat Biol, Ctr Genom Res, Liverpool L69 7ZB, Merseyside, England.
   [Coltart, Cordelia E. M.] UCL, Dept Infect & Populat Hlth, London WC1E 6JB, England.
   [Steer, Damien] Univ Bristol, Res IT, Bristol BS8 1HH, Avon, England.
   [Wright, Callum] Univ Bristol, Adv Comp Res Ctr, Bristol BS8 1HH, Avon, England.
   [Keita, Sakoba] Minist Hlth Guinea, Conakry, Guinea.
   [Drury, Patrick; Formenty, Pierre] WHO, CH-1211 Geneva 27, Switzerland.
   [Diallo, Boubacar] World Hlth Org, Conakry, Guinea.
   [de Clerck, Hilde; Van Herp, Michel; Sprecher, Armand] Med Sans Frontieres, B-1050 Brussels, Belgium.
   [Traore, Alexis] Direct Prefectorale Sante Gueckedou, Sect Prevent & Lutte Malad, Gueckedou, Guinea.
   [Diakite, Mandiou] Univ Gamal Abdel Nasser Conakry, Conakry, Guinea.
   [Konde, Mandy Kader] Hlth & Sustainable Dev Fdn, Conakry, Guinea.
RP Carroll, MW (reprint author), Publ Hlth England, Porton Down SP4 0JG, Wilts, England.
EM miles.carroll@phe.gov.uk
RI Borremans, Benny/D-2241-2009; Di Caro, Antonino/K-6854-2016; Meyer,
   Bernhard/Q-9413-2016; Castilletti, Concetta/B-6545-2016; 
OI meschi, silvia/0000-0003-0924-993X; Borremans,
   Benny/0000-0002-7779-4107; Di Caro, Antonino/0000-0001-6027-3009;
   Gryseels, Sophie/0000-0002-4851-9384; Ngabo, Didier/0000-0003-1818-1439;
   Dudas, Gytis/0000-0002-0227-4158; Capobianchi, Maria
   Rosaria/0000-0003-3465-0071; Hiscox, Julian/0000-0002-6582-0275;
   Castilletti, Concetta/0000-0001-9819-236X; Rappe, Julie Christiane
   FranAoise/0000-0001-9230-0219; Pollakis, Georgios/0000-0002-9659-5461;
   Matthews, David/0000-0003-4611-8795
FU European Union [666100]; Directorate-General for International
   Cooperation and Development [IFS/2011/272-372]
FX The authors would like to acknowledge that the EMLab response and the
   subsequent EBOV genome sequencing study would not have been possible
   without the extensive support from the many different agencies and
   organisations working in the West African EBOV disease outbreak region.
   EMLab worked with WHO, MSF and the Guinean authorities to tackle the
   outbreak in the Gueckedou area where the samples from this study were
   collected. We thank those who helped make this possible and the Guinean
   authorities for their decision to release the diagnostic samples to
   EMLab for shipment to Europe to undergo further analysis, including
   sequencing. We acknowledge Air France, Brussels Airlines and Virgin
   Airlines for transporting EMLab personnel and equipment in and out of
   West Africa during the outbreak period; World Courier for shipping our
   EBOV-positive samples out of Guinea to Europe; and the logistics support
   units and pilots and drivers of WHO/United Nations in West Africa for
   transporting our people and equipment throughout the region, and
   especially the drivers who made the 28h round trip journey from Conakry
   to enable the EMLab unit to be established and resupplied in Gueckedou.
   We appreciate the work of the numerous European Embassies operating in
   West Africa who provided emergency support to our personnel at times of
   need. We thank M. Bull, J. Lewis, P. Payne and S. Leach from the
   Microbial Risk Assessment and Behavioural Science Team, Emergency
   Response Department, Public Health England; J. Tree from Public Health
   England for help with GenBank submission; and S. Price and I. Stewart
   for helping with the running of our software on BlueCrystal, University
   of Bristol. We thank the people of West Africa for their gratitude and
   optimism, and for their positive attitude to our presence that we
   encountered on the daily journey to the Ebola Treatment Centre in
   Gueckedou. We acknowledge the efforts of the late Dr Lamine Ouendeno,
   who was one of the first healthcare workers to die during the current
   EBVD outbreak. We also thank Isabel and Maurice Ouendeno for providing
   us with food and shelter whilst delivering our Ebola response duties.
   This work was carried out in the context of the project EVIDENT (Ebola
   virus disease: correlates of protection, determinants of outcome, and
   clinical management) that received funding from the European Union's
   Horizon 2020 research and innovation programme under grant agreement No
   666100 and in the context of service contract IFS/2011/272-372 funded by
   Directorate-General for International Cooperation and Development. The
   EMLab is a technical partner in the WHO Emerging and Dangerous Pathogens
   Laboratory Network (EDPLN), and the Global Outbreak Alert and Response
   Network (GOARN) and the deployments in West Africa have been coordinated
   and supported by the GOARN Operational Support Team at WHO/HQ.
NR 20
TC 81
Z9 83
U1 16
U2 97
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD AUG 6
PY 2015
VL 524
IS 7563
BP 97
EP U201
DI 10.1038/nature14594
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO2QS
UT WOS:000359002300039
PM 26083749
ER

PT J
AU Mattila, JP
   Shnyrova, AV
   Sundborger, AC
   Hortelano, ER
   Fuhrmans, M
   Neumann, S
   Muller, M
   Hinshaw, JE
   Schmid, SL
   Frolov, VA
AF Mattila, Juha-Pekka
   Shnyrova, Anna V.
   Sundborger, Anna C.
   Rodriguez Hortelano, Eva
   Fuhrmans, Marc
   Neumann, Sylvia
   Mueller, Marcus
   Hinshaw, Jenny E.
   Schmid, Sandra L.
   Frolov, Vadim A.
TI A hemi-fission intermediate links two mechanistically distinct stages of
   membrane fission
SO NATURE
LA English
DT Article
ID DEPENDENT CONFORMATIONAL-CHANGES; DISSIPATIVE PARTICLE DYNAMICS;
   CRYSTAL-STRUCTURE; FUSION; MECHANICS; GTPASE; DOMAIN; SIMULATIONS;
   BILAYERS; BINDING
AB Fusion and fission drive all vesicular transport. Although topologically opposite, these reactions pass through the same hemi-fusion/fission intermediate1,2, characterized by a 'stalk' in which only the outer membrane monolayers of the two compartments have merged to form a localized non-bilayer connection(1-3). Formation of the hemi-fission intermediate requires energy input from proteins catalysing membrane remodelling; however, the relationship between protein conformational rearrangements and hemi-fusion/fission remains obscure. Here we analysed how the GTPase cycle of human dynamin 1, the prototypical membrane fission catalyst(4-6), is directly coupled to membrane remodelling. We used intramolecular chemical crosslinking to stabilize dynamin in its GDP.AlF4--bound transition state. In the absence of GTP this conformer produced stable hemi-fission, but failed to progress to complete fission, even in the presence of GTP. Further analysis revealed that the pleckstrin homology domain (PHD) locked in its membrane-inserted state facilitated hemi-fission. A second mode of dynamin activity, fuelled by GTP hydrolysis, couples dynamin disassembly with cooperative diminishing of the PHD wedging, thus destabilizing the hemi-fission intermediate to complete fission. Molecular simulations corroborate the bimodal character of dynamin action and indicate radial and axial forces as dominant, although not independent, drivers of hemi-fission and fission transformations, respectively. Mirrored in the fusion reaction(7,8), the force bimodality might constitute a general paradigm for leakage-free membrane remodelling.
C1 [Mattila, Juha-Pekka; Schmid, Sandra L.] UT Southwestern Med Ctr, Dept Cell Biol, Dallas, TX 75201 USA.
   [Shnyrova, Anna V.; Rodriguez Hortelano, Eva; Frolov, Vadim A.] Univ Basque Country, Biophys Unit, CSIC, Leioa 48940, Spain.
   [Shnyrova, Anna V.; Rodriguez Hortelano, Eva; Frolov, Vadim A.] Univ Basque Country, Dept Biochem & Mol Biol, Leioa 48940, Spain.
   [Sundborger, Anna C.; Hinshaw, Jenny E.] NIDDK, Lab Cell & Mol Biol, NIH, Bethesda, MD 20892 USA.
   [Fuhrmans, Marc; Mueller, Marcus] Univ Gottingen, Inst Theoret Phys, D-37077 Gottingen, Germany.
   [Neumann, Sylvia] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA.
   [Frolov, Vadim A.] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain.
RP Schmid, SL (reprint author), UT Southwestern Med Ctr, Dept Cell Biol, Dallas, TX 75201 USA.
EM jennyh@helix.nih.gov; sandra.schmid@utsouthwestern.edu;
   vadim.frolov@ehu.eus
RI Muller, Marcus/B-9898-2009; Fuhrmans, Marc/E-2800-2015; Sundborger,
   Anna/J-6590-2014
OI Muller, Marcus/0000-0002-7472-973X; Fuhrmans, Marc/0000-0002-9826-018X;
   Sundborger, Anna/0000-0003-4696-7543
FU National Institutes of Health [R01-GM42455]; Welch Foundation [I-1823];
   Spanish Ministry of Economy and Competitiveness [BFU2012-34885]; Basque
   Government Program Etortek [IE12-332]; European FEDER; National
   Institute of Diabetes and Digestive and Kidney Diseases Intramural
   Research Program; Volkswagen foundation; Academy of Finland; 
   [DFG-CRC803]
FX We thank J. Chappie for helpful discussions, A. Mohanakrishnan and D.
   Reed for technical assistance. S.L.S. was supported by National
   Institutes of Health grant R01-GM42455 and the Welch Foundation Grant
   I-1823. V.A.F. was supported by grants from the Spanish Ministry of
   Economy and Competitiveness BFU2012-34885, the Basque Government Program
   Etortek IE12-332 and European FEDER funds. J.E.H. was supported by the
   National Institute of Diabetes and Digestive and Kidney Diseases
   Intramural Research Program. M.F. and M.M. were supported by the
   Volkswagen foundation and the DFG-CRC803 "Functionality controlled by
   organization in and between membranes" (B03). Simulations were performed
   at the Julich Supercomputing Center and the North-German Supercomputer
   Alliance Hannover/Berlin. J.-P.M. was supported by a postdoctoral
   research grant from the Academy of Finland.
NR 39
TC 11
Z9 11
U1 8
U2 43
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD AUG 6
PY 2015
VL 524
IS 7563
BP 109
EP U243
DI 10.1038/nature14509
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO2QS
UT WOS:000359002300042
PM 26123023
ER

PT J
AU Lee, DH
   Zhang, Y
   Kassam, AB
   Park, MJ
   Gardner, P
   Prevedello, D
   Henry, S
   Horbinski, C
   Beumer, JH
   Tawbi, H
   Williams, BJ
   Shaffrey, ME
   Egorin, MJ
   Abounader, R
   Park, DM
AF Lee, Dae-Hee
   Zhang, Ying
   Kassam, Amin B.
   Park, Myung-Jin
   Gardner, Paul
   Prevedello, Daniel
   Henry, Stephanie
   Horbinski, Craig
   Beumer, Jan H.
   Tawbi, Hussein
   Williams, Brian J.
   Shaffrey, Mark E.
   Egorin, Merrill J.
   Abounader, Roger
   Park, Deric M.
TI Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma
SO PLOS ONE
LA English
DT Article
ID TUMOR-SUPPRESSOR PTEN; PHASE-II; CANCER PROGRESSION; SIGNALING PATHWAY;
   GENE-EXPRESSION; PROSTATE-CANCER; CELL-SURVIVAL; AKT; HIF-1-ALPHA;
   BRACHYURY
AB Background
   The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR). Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypothesized that chordomas resistant to PDGFR inhibition may possess downstream activation of the pathway.
   Methods
   Molecular profiling was performed on 23 consecutive chordoma primary tissue specimens. Primary cultures established from 20 of the 23 specimens, and chordoma cell lines, UCH-1 and UCH-2, were used for in vitro experiments.
   Results
   Loss of heterozygosity (LOH) at the phosphatase and tensin homolog (PTEN) locus was observed in 6 specimens (26%). PTEN disruption statistically correlated with increased Ki-67 proliferation index, an established marker of poor outcome for chordoma. Compared to wild type, PTEN deficient chordomas displayed increased proliferative rate, and responded less favorably to PDGFR inhibition. PTEN gene restoration abrogated this growth advantage. Chordomas are characterized by intratumoral hypoxia and local invasion, and histone deacetylase (HDAC) inhibitors are capable of attenuating both hypoxic signaling and cell migration. The combination of PDGFR and HDAC inhibition effectively disrupted growth and invasion of PTEN deficient chordoma cells.
   Conclusions
   Loss of heterozygosity of the PTEN gene seen in a subset of chordomas is associated with aggressive in vitro behavior and strongly correlates with increased Ki-67 proliferative index. Combined inhibition of PDGFR and HDAC attenuates proliferation and invasion in chordoma cells deficient for PTEN.
C1 [Lee, Dae-Hee; Williams, Brian J.; Shaffrey, Mark E.; Park, Deric M.] Univ Virginia, Dept Neurol Surg, Charlottesville, VA 22908 USA.
   [Zhang, Ying; Abounader, Roger] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA.
   [Kassam, Amin B.; Park, Myung-Jin; Gardner, Paul; Prevedello, Daniel; Henry, Stephanie] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15213 USA.
   [Horbinski, Craig] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15213 USA.
   [Beumer, Jan H.; Tawbi, Hussein; Egorin, Merrill J.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15232 USA.
   [Park, Deric M.] NCI, Neurooncol Branch, NIH, Bethesda, MD 20892 USA.
RP Park, DM (reprint author), Univ Virginia, Dept Neurol Surg, POB 800212, Charlottesville, VA 22908 USA.
EM deric.park@nih.gov
OI Beumer, Jan/0000-0002-8978-9401
FU NCI [U01-CA099168]; ASCO Career Development Award; Novartis
FX This work was funded by U01-CA099168 from the NCI to Jan Beumer, ASCO
   Career Development Award to Deric M. Park and Merrill J. Egorin
   (mentor), and by research support to Deric M. Park, Jan Beumer, and
   Merrill J. Egorin from Novartis. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 46
TC 3
Z9 3
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 6
PY 2015
VL 10
IS 8
AR e0134426
DI 10.1371/journal.pone.0134426
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO3MQ
UT WOS:000359062300036
PM 26247786
ER

PT J
AU Lico, DTP
   Lopes, GS
   Brusco, J
   Rosa, JC
   Gould, RM
   De Giorgis, JA
   Larson, RE
AF Lico, D. T. P.
   Lopes, G. S.
   Brusco, J.
   Rosa, J. C.
   Gould, R. M.
   De Giorgis, J. A.
   Larson, R. E.
TI A NOVEL SDS-STABLE DIMER OF A HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN AT
   PRESYNAPTIC TERMINALS OF SQUID NEURONS
SO NEUROSCIENCE
LA English
DT Article
DE hnRNP; ribonucleoprotein; presynaptic terminus; synaptosome; ELAV; squid
ID LOCAL PROTEIN-SYNTHESIS; MESSENGER-RNAS; SYNAPTOSOMAL FRACTION; SYNAPTIC
   PLASTICITY; BINDING PROTEIN; LOLIGO-PEALEI; GIANT-AXON; TRANSLATION;
   BRAIN; TRAFFICKING
AB The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation. Defects in these processes and mutations in components of the hnRNP complexes have been related to the formation of cytoplasmic inclusion bodies and neurodegenerative diseases. Despite much data on mRNA localization and evidence for protein synthesis, as well as the presence of translation machinery, in axons and presynaptic terminals, the identity of RNA-binding proteins involved in RNA transport and function in presynaptic regions is lacking. We previously characterized a strongly basic RNA-binding protein (p65), member of the hnRNPA/B subfamily, in squid presynaptic terminals. Intriguingly, in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), p65 migrated as a 65-kDa protein, whereas members of the hnRNPA/B family typically have molecular masses ranging from 35 to 42 kDa. In this report we present further biochemical and molecular characterization that shows endogenous p65 to be an SDS-stable dimer composed of similar to 37-kDa hnRNPA/B-like subunits. We cloned and expressed a recombinant protein corresponding to squid hnRNPA/B-like protein and showed its propensity to aggregate and form SDS-stable dimers in vitro. Our data suggest that this unique hnRNPA/B-like protein colocalizes with synaptic vesicle protein 2 and RNA-binding protein ELAV and thus may serve as a link between local mRNA processing and presynaptic function and regulation. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Lico, D. T. P.; Lopes, G. S.; Brusco, J.; Rosa, J. C.; Larson, R. E.] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Cellular & Mol Biol, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Gould, R. M.] Marine Biol Lab, Program Sensory Physiol & Behav, Woods Hole, MA 02543 USA.
   [De Giorgis, J. A.] Providence Coll, Dept Biol, Providence, RI 02918 USA.
   [De Giorgis, J. A.] NINDS, NIH, Bethesda, MD 20892 USA.
   [Lico, D. T. P.; Lopes, G. S.; Brusco, J.; De Giorgis, J. A.; Larson, R. E.] Marine Biol Lab, Woods Hole, MA 02543 USA.
RP Larson, RE (reprint author), Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Cellular & Mol Biol, BR-14049900 Ribeirao Preto, SP, Brazil.
EM ditplico@usp.br; gabrielsl@usp.br; janabrusco@gmail.com;
   jcrosa@fmrp.usp.br; rmgould48@gmail.com; joe_degiorgis@hotmail.com;
   relarson@fmrp.usp.br
RI Rosa, Jose /A-1966-2013
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Fundacao de
   Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da
   FMRP-USP (FAEPA); National Institute of General Medical Sciences, NIH,
   Bethesda, MD [8 P20 GM103430-12]; FAPESP; CNPq
FX Research was supported by grants to REL from the Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP), the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) and the Fundacao de
   Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da
   FMRP-USP (FAEPA). JAD received financial support from the RI-INBRE
   Program Grant #8 P20 GM103430-12 from the National Institute of General
   Medical Sciences, NIH, Bethesda, MD. DTPL and GSL received research
   fellowships from FAPESP and CNPq. REL and JCR received the
   Productivity-in-Research fellowship from CNPq. Special thanks to Jeff
   Gross and Kristen Koenig, University of Texas at Austin for making
   available their squid embryo RNA library for data mining. Also thanks to
   Silvia Andrade for expert technical help. The authors declare no
   competing financial interests.
NR 49
TC 0
Z9 0
U1 2
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD AUG 6
PY 2015
VL 300
BP 381
EP 392
DI 10.1016/j.neuroscience.2015.05.040
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA CL2IQ
UT WOS:000356767400036
PM 26012490
ER

PT J
AU Levy, JM
   Chen, XB
   Reese, TS
   Nicoll, RA
AF Levy, Jonathan M.
   Chen, Xiaobing
   Reese, Thomas S.
   Nicoll, Roger A.
TI Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK
   Loss
SO NEURON
LA English
DT Article
ID LONG-TERM POTENTIATION; PROTEIN-KINASE KINASE; POSTSYNAPTIC DENSITY;
   EXCITATORY SYNAPSES; DENDRITIC SPINES; HIPPOCAMPAL SYNAPSES; RECEPTOR
   TRAFFICKING; SCAFFOLDING PROTEINS; NMDA RECEPTORS; IN-VIVO
AB The mechanisms controlling synapse growth and maintenance are of critical importance for learning and memory. The MAGUK family of synaptic scaffolding proteins is abundantly expressed at glutamatergic central synapses, but their importance in controlling the synaptic content of glutamate receptors is poorly understood. Here, we use a chained RNA-imediated knockdown approach to simultaneously remove PSD-93, PSD-95, and SAP102, the MAGUKs previously shown to be responsible for synaptic localization of glutamate receptors. We find that MAGUKs are specifically responsible for creating functional synapses after initial spine formation by filling functionally silent spines with glutamate receptors. Removal of the MAGUKs causes a transient reduction in AMPA receptor quantal size followed by synaptic consolidation resulting in a normalization of quantal size at the few remaining functional synapses. Consolidation requires signaling through L-type calcium channels, CaM kinase kinase, and the GluA2 AMPA receptor subunit, akin to a homeostatic process.
C1 [Levy, Jonathan M.] Univ Calif San Francisco, Neurosci Grad Program, San Francisco, CA 94158 USA.
   [Levy, Jonathan M.; Nicoll, Roger A.] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA.
   [Chen, Xiaobing; Reese, Thomas S.] NINDS, Neurobiol Lab, NIH, Bethesda, MD 20892 USA.
RP Nicoll, RA (reprint author), Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA.
EM roger.nicoll@ucsf.edu
FU U.S. National Institute of Mental Health
FX We thank W. Swat for the SAP97 mice, D. Julius for the human CaV 1.2
   cDNA, and T. Soderling for the CaMKK cDNA. We thank K. Bjorgan and M.
   Cerpas for technical assistance, and all members of the Nicoll
   laboratory for discussion of and comments on the manuscript. This work
   was supported by grants from the U.S. National Institute of Mental
   Health.
NR 59
TC 10
Z9 10
U1 2
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD AUG 5
PY 2015
VL 87
IS 3
BP 534
EP 548
DI 10.1016/j.neuron.2015.07.015
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA CR2GR
UT WOS:000361145000008
PM 26247861
ER

PT J
AU Serchov, T
   Clement, HW
   Schwarz, MK
   Iasevoli, F
   Tosh, DK
   Idzko, M
   Jacobson, KA
   de Bartolomeis, A
   Normann, C
   Biber, K
   van Calker, D
AF Serchov, Tsvetan
   Clement, Hans-Willi
   Schwarz, Martin K.
   Iasevoli, Felice
   Tosh, Dilip K.
   Idzko, Marco
   Jacobson, Kenneth A.
   de Bartolomeis, Andrea
   Normann, Claus
   Biber, Knut
   van Calker, Dietrich
TI Increased Signaling via Adenosine A(1) Receptors, Sleep Deprivation,
   Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction
   of Homer1a
SO NEURON
LA English
DT Article
ID PYRAMIDAL CELL EXCITABILITY; PHOSPHOLIPASE-C; MICE LACKING; ECONOMIC
   BURDEN; HUMAN BRAIN; RAT-BRAIN; ACTIVATION; STIMULATION; MECHANISMS;
   EXPRESSION
AB Major depressive disorder is among the most commonly diagnosed disabling mental diseases. Several non-pharmacological treatments of depression upregulate adenosine concentration and/or adenosine A(1) receptors (A(1)R) in the brain. To test whether enhanced A(1)R signaling mediates antidepressant effects, we generated a transgenic mouse with enhanced doxycycline-regulated A(1)R expression, specifically in forebrain neurons. Upregulating A(1)R led to pronounced acute and chronic resilience toward depressive-like behavior in various tests. Conversely, A(1)R knockout mice displayed an increased depressive-like behavior and were resistant to the antidepressant effects of sleep deprivation (SD). Various antidepressant treatments increase homer1a expression in medial prefrontal cortex (mPFC). Specific siRNA knockdown of homer1a in mPFC enhanced depressive-like behavior and prevented the antidepressant effects of A(1)R up-regulation, SD, imipramine, and ketamine treatment. In contrast, viral overexpression of homer1a in the mPFC had antidepressant effects. Thus, increased expression of homer1a is a final common pathway mediating the antidepressant effects of different antidepressant treatments.
C1 [Serchov, Tsvetan; Normann, Claus; Biber, Knut; van Calker, Dietrich] Univ Med Ctr Freiburg, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
   [Clement, Hans-Willi] Univ Med Ctr Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
   [Schwarz, Martin K.] Univ Bonn, Sch Med, Dept Epileptol, Funct Neuroconnect Grp, D-53105 Bonn, Germany.
   [Iasevoli, Felice; de Bartolomeis, Andrea] Univ Naples Federico II, Dept Neurosci, Lab Mol & Translat Psychiat, I-80131 Naples, Italy.
   [Tosh, Dilip K.; Jacobson, Kenneth A.] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Idzko, Marco] Univ Med Ctr, Dept Pneumol, D-79104 Freiburg, Germany.
   [Biber, Knut] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AV Groningen, Netherlands.
RP Biber, K (reprint author), Univ Med Ctr Freiburg, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
EM knut.biber@uniklinik-freiburg.de; dietrich.calker@uniklinik-freiburg.de
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU German Research Council (DFG) [CA 115/5-4]; European Union; German
   Ministry for Research and Education (DMBF) [B: 031 6174A]
FX We thank I. Schwarz for the preparation and purification of the rAAVs,
   K.-P. Knobeloch for sharing plasmids, and A.-L. Baumann, D. Paul, and L.
   Funer for the excellent technical support. Imaging experiments were done
   at the Imaging unit of the ZBSA Freiburg. The study was funded by grants
   from the German Research Council (DFG) (CA 115/5-4) to D.v.C. and K.B.,
   the European Union FP7 program "MoodInflame'' to D.v.C., and German
   Ministry for Research and Education (DMBF) grant e:bio - Modul I -
   ReelinSys (Project B: 031 6174A) to K.B.
NR 58
TC 15
Z9 15
U1 2
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD AUG 5
PY 2015
VL 87
IS 3
BP 549
EP 562
DI 10.1016/j.neuron.2015.07.010
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA CR2GR
UT WOS:000361145000009
PM 26247862
ER

PT J
AU Rosenberg, AS
   Puig, M
   Nagaraju, K
   Hoffman, EP
   Villalta, SA
   Rao, VA
   Wakefield, LM
   Woodcock, J
AF Rosenberg, Amy S.
   Puig, Montserrat
   Nagaraju, Kanneboyina
   Hoffman, Eric P.
   Villalta, S. Armando
   Rao, V. Ashutosh
   Wakefield, Lalage M.
   Woodcock, Janet
TI Immune-mediated pathology in Duchenne muscular dystrophy
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Review
ID REGULATORY T-CELLS; GROWTH-FACTOR-BETA; MDX MOUSE MODEL; TOLL-LIKE
   RECEPTORS; SKELETAL-MUSCLE; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1;
   INFLAMMATORY RESPONSE; DISEASE PROGRESSION; DEFICIENT SKELETAL
AB Immunological and inflammatory processes downstream of dystrophin deficiency as well asmetabolic abnormalities, defective autophagy, and loss of regenerative capacity all contribute to muscle pathology in Duchenne muscular dystrophy (DMD). These downstream cascades offer potential avenues for pharmacological intervention. Modulating the inflammatory response and inducing immunological tolerance to de novo dystrophin expression will be critical to the success of dystrophin-replacement therapies. This Review focuses on the role of the inflammatory response in DMD pathogenesis and opportunities for clinical intervention.
C1 [Rosenberg, Amy S.; Puig, Montserrat; Rao, V. Ashutosh; Woodcock, Janet] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA.
   [Nagaraju, Kanneboyina; Hoffman, Eric P.] Childrens Natl Med Ctr, Ctr Genet Med Res, Washington, DC 20010 USA.
   [Villalta, S. Armando] Univ Calif Irvine, Dept Physiol & Biophys, Inst Immunol, Irvine, CA 92697 USA.
   [Wakefield, Lalage M.] NCI, Lab Canc Biol & Genet, Bethesda, MD 20892 USA.
RP Rosenberg, AS (reprint author), US FDA, Ctr Drug Evaluat & Res, Bldg 71-2238, Silver Spring, MD 20993 USA.
EM amy.rosenberg@fda.hhs.gov
FU NINDS NIH HHS [R01 NS029525]
NR 109
TC 8
Z9 9
U1 3
U2 12
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD AUG 5
PY 2015
VL 7
IS 299
AR 299rv4
DI 10.1126/scitranslmed.aaa7322
PG 12
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA CQ9MX
UT WOS:000360940300006
PM 26246170
ER

PT J
AU Jablonka, W
   Kotsyfakis, M
   Mizurini, DM
   Monteiro, RQ
   Lukszo, J
   Drake, SK
   Ribeiro, JMC
   Andersen, JF
AF Jablonka, Willy
   Kotsyfakis, Michalis
   Mizurini, Daniella M.
   Monteiro, Robson Q.
   Lukszo, Jan
   Drake, Steven K.
   Ribeiro, Jose M. C.
   Andersen, John F.
TI Identification and Mechanistic Analysis of a Novel Tick-Derived
   Inhibitor of Thrombin
SO PLOS ONE
LA English
DT Article
ID HAEMAPHYSALIS-LONGICORNIS; BINDING INHIBITOR; CRYSTAL-STRUCTURE;
   SALIVARY-GLAND; COMPLEX; ACTIVATION; IXODIDAE; PROTEIN
AB A group of peptides from the salivary gland of the tick Hyalomma marginatum rufipes, a vector of Crimean Congo hemorrhagic fever show weak similarity to the madanins, a group of thrombin-inhibitory peptides from a second tick species, Haemaphysalis longicornis. We have evaluated the anti-serine protease activity of one of these H. marginatum peptides that has been given the name hyalomin-1. Hyalomin-1 was found to be a selective inhibitor of thrombin, blocking coagulation of plasma and inhibiting S2238 hydrolysis in a competitive manner with an inhibition constant (Ki) of 12 nM at an ionic strength of 150 mM. It also blocks the thrombin-mediated activation of coagulation factor XI, thrombin-mediated platelet aggregation, and the activation of coagulation factor V by thrombin. Hyalomin-1 is cleaved at a canonical thrombin cleavage site but the cleaved products do not inhibit coagulation. However, the C-terminal cleavage product showed non-competitive inhibition of S2238 hydrolysis. A peptide combining the N-terminal parts of the molecule with the cleavage region did not interact strongly with thrombin, but a 24-residue fragment containing the cleavage region and the C-terminal fragment inhibited the enzyme in a competitive manner and also inhibited coagulation of plasma. These results suggest that the peptide acts by binding to the active site as well as exosite I or the autolysis loop of thrombin. Injection of 2.5 mg/kg of hyalomin-1 increased arterial occlusion time in a mouse model of thrombosis, suggesting this peptide could be a candidate for clinical use as an antithrombotic.
C1 [Jablonka, Willy; Ribeiro, Jose M. C.; Andersen, John F.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20892 USA.
   [Kotsyfakis, Michalis] Acad Sci Czech Republic, Inst Parasitol, CR-37005 Ceske Budejovice, Czech Republic.
   [Mizurini, Daniella M.; Monteiro, Robson Q.] Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo de Meis, Rio De Janeiro, Brazil.
   [Lukszo, Jan] NIAID, Res Technol Branch, NIH, Rockville, MD USA.
   [Drake, Steven K.] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA.
RP Andersen, JF (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20892 USA.
EM jandersen@niaid.nih.gov
RI Monteiro, Robson/B-8007-2014; Kotsyfakis, Michail/G-9525-2014; Jablonka,
   Willy/D-2333-2017; 
OI Kotsyfakis, Michail/0000-0002-7526-1876; Ribeiro,
   Jose/0000-0002-9107-0818
FU NIAID, National Institutes of Health; Brazilian National Council for
   Scientific and Technological Development (CNPq); State of Rio de Janeiro
   Research Foundation (FAPERJ); Grant Agency of the Czech Republic (GACR)
   [P502/12/2409]; Academy of Sciences of the Czech Republic
FX This work was supported by the intramural research program of the NIAID,
   National Institutes of Health, the Brazilian National Council for
   Scientific and Technological Development (CNPq) for WJ, RQM and DMM, The
   State of Rio de Janeiro Research Foundation (FAPERJ) for RQM and DM, the
   Grant Agency of the Czech Republic (GACR grant P502/12/2409 to MK) and
   by the Academy of Sciences of the Czech Republic (Jan Evangelista
   Purkyne Fellowship and Intramural support to MK).
NR 26
TC 2
Z9 3
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 5
PY 2015
VL 10
IS 8
AR e0133991
DI 10.1371/journal.pone.0133991
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO3MH
UT WOS:000359061400061
PM 26244557
ER

PT J
AU Xiong, Y
   Kotian, S
   Zeiger, MA
   Zhang, L
   Kebebew, E
AF Xiong, Yin
   Kotian, Shweta
   Zeiger, Martha A.
   Zhang, Lisa
   Kebebew, Electron
TI miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is
   Associated with Aggressive Thyroid Cancer
SO PLOS ONE
LA English
DT Article
ID CANDIDATE DIAGNOSTIC MICRORNAS; AMINO-ACID TRANSPORTER-1; HUMAN
   BREAST-CANCER; LUNG-CANCER; PANCREATIC-CANCER; TUMOR-SUPPRESSOR;
   PROSTATE-CANCER; MESSENGER-RNA; EXPRESSION; ADAM9
AB Background
   Previous studies have shown that microRNAs are dysregulated in thyroid cancer and play important roles in the post-transcriptional regulation of target oncogenes and/or tumor suppressor genes.
   Methodology/Principal Findings
   We studied the function of miR-126-3p in thyroid cancer cells, and as a marker of disease aggressiveness. We found that miR-126-3p expression was significantly lower in larger tumors, in tumor samples with extrathyroidal invasion, and in higher risk group thyroid cancer in 496 papillary thyroid cancer samples from The Cancer Genome Atlas study cohort. In an independent sample set, lower miR-126-3p expression was observed in follicular thyroid cancers (which have capsular and angioinvasion) as compared to follicular adenomas. Mechanistically, ectopic overexpression of miR-126-3p significantly inhibited thyroid cancer cell proliferation, in vitro (p<0.01) and in vivo (p<0.01), colony formation (p<0.01), tumor spheroid formation (p<0.05), cellular migration (p<0.05), VEGF secretion and endothelial tube formation, and lung metastasis in vivo. We found 14 predicted target genes, which were significantly altered upon miR-126-3p transfection in thyroid cancer cells, and which are involved in cancer biology. Of these 14 genes, SLC7A5 and ADAM9 were confirmed to be inhibited by miR-126-3p overexpression and to be direct targets of miR-136-3p.
   Conclusions/Significance
   To our knowledge, this is the first study to demonstrate that miR-126-3p has a tumor-suppressive function in thyroid cancer cells, and is associated with aggressive disease phenotype.
C1 [Xiong, Yin; Kotian, Shweta; Zhang, Lisa; Kebebew, Electron] NCI, Endocrine Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Zeiger, Martha A.] Johns Hopkins Univ, Dept Surg, Baltimore, MD USA.
RP Kebebew, E (reprint author), NCI, Endocrine Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
EM kebebewe@mail.nih.gov
FU intramural research program of the Center for Cancer Research, National
   Cancer Institute, National Institutes of Health
FX This research was supported by the intramural research program of the
   Center for Cancer Research, National Cancer Institute, National
   Institutes of Health. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. The authors have no conflicts of interests to disclose.
NR 50
TC 12
Z9 12
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 5
PY 2015
VL 10
IS 8
AR e0130496
DI 10.1371/journal.pone.0130496
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO3MH
UT WOS:000359061400005
PM 26244545
ER

PT J
AU Henry, H
   Naujokas, MF
   Attanayake, C
   Basta, NT
   Cheng, ZQ
   Hettiarachchi, GM
   Maddaloni, M
   Schadt, C
   Scheckel, KG
AF Henry, Heather
   Naujokas, Marisa F.
   Attanayake, Chammi
   Basta, Nicholas T.
   Cheng, Zhongqi
   Hettiarachchi, Ganga M.
   Maddaloni, Mark
   Schadt, Christopher
   Scheckel, Kirk G.
TI Bioavailability-Based In Situ Remediation To Meet Future Lead (Pb)
   Standards in Urban Soils and Gardens
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Review
ID FIRING RANGE SOILS; SMELTER-CONTAMINATED SOIL; ZERO-VALENT IRON; BLOOD
   LEAD; RELATIVE BIOAVAILABILITY; MANGANESE OXIDE; CHEMICAL
   IMMOBILIZATION; ORAL BIOACCESSIBILITY; PHOSPHORUS AMENDMENTS; METAL
   IMMOBILIZATION
AB Recently the Centers for Disease Control and Prevention lowered the blood Pb reference value to 5 mu g/dL. The lower reference value combined with increased repurposing of postindustrial lands are heightening concerns and driving interest in reducing soil Pb exposures. As a result, regulatory decision makers may lower residential soil screening levels (SSLs), used in setting Pb cleanup levels, to levels that may be difficult to achieve, especially in urban areas. This paper discusses challenges in remediation and bioavailability assessments of Pb in urban soils in the context of lower SSLs and identifies research needs to better address those challenges. Although in situ remediation with phosphate amendments is a viable option, the scope of the problem and conditions in urban settings may necessitate that SSLs be based on bioavailable rather than total Pb concentrations. However, variability in soil composition can influence bioavailability testing and soil amendment effectiveness. More urgently needed to better understand this variability and increase confidence in using these approaches in risk-based making, particularly in urban areas. data are decision
C1 [Naujokas, Marisa F.] MDB Inc, Durham, NC 27713 USA.
   [Basta, Nicholas T.] Ohio State Univ, Sch Environm & Nat Resources, Columbus, OH 43210 USA.
   [Cheng, Zhongqi] CUNY Brooklyn Coll, Brooklyn, NY 11210 USA.
   [Hettiarachchi, Ganga M.] Kansas State Univ, Dept Agron, Manhattan, KS 66506 USA.
   [Maddaloni, Mark] US EPA Reg 2, New York, NY 10007 USA.
   [Schadt, Christopher] Oak Ridge Natl Lab, Biosci Div, Oak Ridge, TN 37831 USA.
   [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
   [Attanayake, Chammi] Univ Peradeniya, Dept Soil Sci, Peradeniya 20400, Sri Lanka.
   [Henry, Heather] NIEHS, Hazardous Subst Res Branch, Res Triangle Pk, NC 27709 USA.
RP Naujokas, MF (reprint author), MDB Inc, 2525 Meridian Pkwy,Suite 50, Durham, NC 27713 USA.
EM mnaujokas@michaeldbaker.com
RI Schadt, Christopher/B-7143-2008; 
OI Schadt, Christopher/0000-0001-8759-2448; Scheckel,
   Kirk/0000-0001-9326-9241
FU National Institutes of Health's National Institute of Environmental
   Health Sciences (NIEHS); U.S. Department of Defense/Department of
   Energy/EPA Strategic Environmental Research and Development Program
   (SERDP); Kansas Agricultural Experimental Station [14-296-J]; Ohio
   Agricultural Research and Development Center of The Ohio State
   University
FX This work was supported in part by the National Institutes of Health's
   National Institute of Environmental Health Sciences (NIEHS); and the
   joint U.S. Department of Defense/Department of Energy/EPA Strategic
   Environmental Research and Development Program (SERDP). This work was
   also supported in part through Contribution Number 14-296-J from the
   Kansas Agricultural Experimental Station. Partial salary support for N.
   Basta was provided by the Ohio Agricultural Research and Development
   Center of The Ohio State University. Although researchers from the EPA
   contributed to this article, the research presented was not subject to
   EPA's quality system requirements. Consequently, the views,
   interpretations, and conclusions expressed in this article are solely
   those of the authors and do not necessarily reflect or represent views
   or policies of EPA, NIH, NIEHS, or the United States Government, nor
   does mention of trade names, commercial products, or organizations imply
   endorsement by the U.S. Government.
NR 146
TC 13
Z9 14
U1 27
U2 109
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 4
PY 2015
VL 49
IS 15
BP 8948
EP 8958
DI 10.1021/acs.est.5b01693
PG 11
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CO6PK
UT WOS:000359278400004
PM 26140328
ER

PT J
AU Tian, Y
   Schwieters, CD
   Opella, SJ
   Marassi, FM
AF Tian, Ye
   Schwieters, Charles D.
   Opella, Stanley J.
   Marassi, Francesca M.
TI A Practical Implicit Membrane Potential for NMR Structure Calculations
   of Membrane Proteins
SO BIOPHYSICAL JOURNAL
LA English
DT Article
ID SOLID-STATE NMR; MOLECULAR-STRUCTURE DETERMINATION; EFFECTIVE ENERGY
   FUNCTION; STRUCTURE VALIDATION; LIPID-BILAYERS; EXPLICIT MEMBRANES;
   CONFORMATIONAL DATABASE; BIOMOLECULAR SIMULATION; 3-DIMENSIONAL
   STRUCTURE; STRUCTURE REFINEMENT
AB The highly anisotropic environment of the lipid bilayer membrane imposes significant constraints on the structures and functions of membrane proteins. However, NMR structure calculations typically use a simple repulsive potential that neglects the effects of solvation and electrostatics, because explicit atomic representation of the solvent and lipid molecules is computationally expensive and impractical for routine NMR-restrained calculations that start from completely extended polypeptide templates. Here, we describe the extension of a previously described implicit solvation potential, eefxPot, to include a membrane model for NMR-restrained calculations of membrane protein structures in XPLOR-NIH. The key components of eefxPot are an energy term for solvation free energy that works together with other nonbonded energy functions, a dedicated force field for conformational and nonbonded protein interaction parameters, and a membrane function that modulates the solvation free energy and dielectric screening as a function of the atomic distance from the membrane center, relative to the membrane thickness. Initial results obtained for membrane proteins with structures determined experimentally in lipid bilayer membranes show that eefxPot affords significant improvements in structural quality, accuracy, and precision. Calculations with eefxPot are straightforward to implement and can be used to both fold and refine structures, as well as to run unrestrained molecular-dynamics simulations. The potential is entirely compatible with the full range of experimental restraints measured by various techniques. Overall, it provides a useful and practical way to calculate membrane protein structures in a physically realistic environment.
C1 [Tian, Ye; Marassi, Francesca M.] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA.
   [Tian, Ye; Opella, Stanley J.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA.
   [Schwieters, Charles D.] NIH, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
RP Marassi, FM (reprint author), Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA.
EM fmarassi@sbmri.org
FU National Institutes of Health [R01 GM110658, P41 EB002031]; NIH
   Intramural Research Program of the Center for Information Technology
FX This research was supported by grants from the National Institutes of
   Health (R01 GM110658 and P41 EB002031). C.D.S. was supported by funds
   from the NIH Intramural Research Program of the Center for Information
   Technology.
NR 78
TC 1
Z9 1
U1 2
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
EI 1542-0086
J9 BIOPHYS J
JI Biophys. J.
PD AUG 4
PY 2015
VL 109
IS 3
BP 574
EP 585
DI 10.1016/j.bpj.2015.06.047
PG 12
WC Biophysics
SC Biophysics
GA CO5DS
UT WOS:000359180400014
PM 26244739
ER

PT J
AU Roy, A
   Jana, M
   Kundu, M
   Corbett, GT
   Rangaswamy, SB
   Mishra, RK
   Luan, CH
   Gonzalez, FJ
   Pahan, K
AF Roy, Avik
   Jana, Malabendu
   Kundu, Madhuchhanda
   Corbett, Grant T.
   Rangaswamy, Suresh B.
   Mishra, Rama K.
   Luan, Chi-Hao
   Gonzalez, Frank J.
   Pahan, Kalipada
TI HMG-CoA Reductase Inhibitors Bind to PPAR alpha to Upregulate
   Neurotrophin Expression in the Brain and Improve Memory in Mice
SO CELL METABOLISM
LA English
DT Article
ID CHOLESTEROL-METABOLISM; ALZHEIMERS-DISEASE; HUNTINGTON-DISEASE;
   NITRIC-OXIDE; MOUSE MODEL; T-CELLS; BDNF; NEURONS; ACTIVATION; STATINS
AB Neurotrophins are important for neuronal health and function. Here, statins, inhibitors of HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of neurotrophins in brain cells independent of the mevalonate pathway. Time-resolved fluorescence resonance energy transfer (FRET) analyses, computer-derived simulation, site-directed mutagenesis, thermal shift assay, and de novo binding followed by electrospray ionization tandem mass spectrometry (ESI-MS) demonstrates that statins serve as ligands of PPAR alpha and that Leu331 and Tyr 334 residues of PPARa are important for statin binding. Upon binding, statins upregulate neurotrophins via PPAR alpha-mediated transcriptional activation of cAMP-response element binding protein (CREB). Accordingly, simvastatin increases CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus of Ppara null mice receiving full-length lentiviral PPARa, but not L331M/Y334D statin-binding domain-mutated lentiviral PPARa. This study identifies statins as ligands of PPARa, describes neurotrophic function of statins via the PPAR alpha-CREB pathway, and analyzes the importance of PPARa in the therapeutic success of simvastatin in an animal model of Alzheimer's disease.
C1 [Roy, Avik; Jana, Malabendu; Kundu, Madhuchhanda; Corbett, Grant T.; Rangaswamy, Suresh B.; Pahan, Kalipada] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
   [Mishra, Rama K.] Northwestern Univ, Ctr Mol Innovat & Drug Discovery, Evanston, IL 60208 USA.
   [Luan, Chi-Hao] Northwestern Univ, Weinberg Coll Arts & Sci, Evanston, IL 60208 USA.
   [Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Pahan, Kalipada] Jesse Brown Vet Affairs Med Ctr, Div Res & Dev, Chicago, IL 60612 USA.
RP Pahan, K (reprint author), Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
EM kalipada_pahan@rush.edu
FU NIH [AT6681, NS83054]; Alzheimer's Association [IIRG-12-241179]; Chicago
   Biomedical Consortium
FX This study was supported by grants from NIH (AT6681 and NS83054) and
   Alzheimer's Association (IIRG-12-241179). The authors would like to
   thank ChemCore at the Center for Molecular Innovation and Drug
   Discovery, Northwestern University, funded by the Chicago Biomedical
   Consortium.
NR 37
TC 14
Z9 14
U1 3
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD AUG 4
PY 2015
VL 22
IS 2
BP 253
EP 265
DI 10.1016/j.cmet.2015.05.022
PG 13
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA CO2QA
UT WOS:000359000500011
PM 26118928
ER

PT J
AU Lomash, RM
   Gu, XL
   Youle, RJ
   Lu, W
   Roche, KW
AF Lomash, Richa Madan
   Gu, Xinglong
   Youle, Richard J.
   Lu, Wei
   Roche, Katherine W.
TI Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and
   Spine Density
SO CELL REPORTS
LA English
DT Article
ID SMITH-MAGENIS-SYNDROME; UBIQUITIN LIGASE; FINGER PROTEIN; DENDRITIC
   SPINES; ENDOCYTOSIS; PLASTICITY; ZNF179; UBIQUITYLATION; DIMERIZATION;
   EXPRESSION
AB Membrane trafficking and spinogenesis contribute significantly to changes in synaptic strength during development and in various paradigms of synaptic plasticity. GTPases of the dynamin family are key players regulating membrane trafficking. Here, we identify a brain-specific dynamin family GTPase, neurolastin (RNF112/Znf179), with closest homology to atlastin. We demonstrate that neurolastin has functional GTPase and RING domains, making it a unique protein identified with this multi-enzymatic domain organization. We also show that neurolastin is a peripheral membrane protein that localizes to endosomes and affects endosomal membrane dynamics via its RING domain. In addition, neurolastin knockout mice have fewer dendritic spines, and rescue of the wild-type phenotype requires both the GTPase and RING domains. Furthermore, we find fewer functional synapses and reduced paired pulse facilitation in neurolastin knockout mice. Thus, we identify neurolastin as a dynamin family GTPase that affects endosome size and spine density.
C1 [Lomash, Richa Madan; Roche, Katherine W.] NINDS, Receptor Biol Sect, NIH, Bethesda, MD 20892 USA.
   [Gu, Xinglong; Lu, Wei] NINDS, Synapse & Neural Circuit Res Unit, NIH, Bethesda, MD 20892 USA.
   [Youle, Richard J.] NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
RP Roche, KW (reprint author), NINDS, Receptor Biol Sect, NIH, Bethesda, MD 20892 USA.
EM rochek@ninds.nih.gov
RI gu, xinglong/A-3054-2011; 
OI gu, xinglong/0000-0002-0437-5606; Roche, Katherine/0000-0001-7282-6539
FU NINDS Intramural Research Program
FX We thank Stephanie McNeil who initiated this study as part of her
   doctoral thesis at Johns Hopkins University. We also thank John D.
   Badger II and Kai Chang for their technical assistance. We are grateful
   to Dr. James Pickel and the NIMH transgenic facility for their help in
   the generation of the KO mouse. We thank the NINDS sequencing, imaging,
   and animal facility for their assistance. We would like to thank the
   members of the K.W.R., C. Blackstone, and R.J.Y. laboratories for their
   helpful discussions. This research was supported by the NINDS Intramural
   Research Program (to R.M.L., X.G., W.L., R.J.Y., and K.W.R.).
NR 31
TC 2
Z9 2
U1 0
U2 4
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD AUG 4
PY 2015
VL 12
IS 5
BP 743
EP 751
DI 10.1016/j.celrep.2015.06.064
PG 9
WC Cell Biology
SC Cell Biology
GA CO2PT
UT WOS:000358999800004
PM 26212327
ER

PT J
AU Di Giovanni, J
   Sheng, ZH
AF Di Giovanni, Jerome
   Sheng, Zu-Hang
TI Regulation of synaptic activity by snapin-mediated endolysosomal
   transport and sorting
SO EMBO JOURNAL
LA English
DT Article
DE BLOC-1; dynein motor; dysbindin; endosomal sorting and transport; snapin
ID LYSOSOME-RELATED ORGANELLES; SCHIZOPHRENIA SUSCEPTIBILITY GENE; CULTURED
   HIPPOCAMPAL-NEURONS; READILY RELEASABLE POOL; RECYCLING VESICLE POOL;
   TRANSMITTER RELEASE; NEUROTRANSMITTER RELEASE; CA2+ CHANNELS; EXCITATORY
   SYNAPSES; ENDOCYTIC PATHWAYS
AB Recycling synaptic vesicles (SVs) transit through early endosomal sorting stations, which raises a fundamental question: are SVs sorted toward endolysosomal pathways? Here, we used snapin mutants as tools to assess how endolysosomal sorting and trafficking impact presynaptic activity in wild-type and snapin(-/-) neurons. Snapin acts as a dynein adaptor that mediates the retrograde transport of late endosomes (LEs) and interacts with dysbindin, a subunit of the endosomal sorting complex BLOC-1. Expressing dynein-binding defective snapin mutants induced SV accumulation at presynaptic terminals, mimicking the snapin(-/-) phenotype. Conversely, over-expressing snapin reduced SV pool size by enhancing SV trafficking to the endolysosomal pathway. Using a SV-targeted Ca2+ sensor, we demonstrate that snapin-dysbindin interaction regulates SV positional priming through BLOC-1/AP-3-dependent sorting. Our study reveals a bipartite regulation of presynaptic activity by endolysosomal trafficking and sorting: LE transport regulates SV pool size, and BLOC-1/AP-3-dependent sorting fine-tunes the Ca2+ sensitivity of SV release. Therefore, our study provides new mechanistic insights into the maintenance and regulation of SV pool size and synchronized SV fusion through snapin-mediated LE trafficking and endosomal sorting.
C1 [Di Giovanni, Jerome; Sheng, Zu-Hang] NINDS, Synapt Funct Sect, Porter Neurosci Res Ctr, NIH, Bethesda, MD 20892 USA.
RP Sheng, ZH (reprint author), NINDS, Synapt Funct Sect, Porter Neurosci Res Ctr, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM shengz@ninds.nih.gov
FU Intramural Research Program of NINDS, NIH [ZIA HS003029, ZIA NS002946]
FX The authors would like to thank the following people for their help:
   Timothy Ryan for the kind gift of VGluT-mCherry-pHluorin and
   VGluT-mOrange plasmids; Kevin Staras for dendra-synaptophysin; Wei Li
   for dysbindin antibody and constructs; Susan Cheng and Virginia Crocker
   at the NINDS facility for electron microscopy; D. Krepkiy in the Swartz
   laboratory for help with CD spectra acquisitions; members of the Sheng
   laboratory for helpful discussions; and Devera Schoenberg for proof
   editing. The work was supported by the Intramural Research Program of
   NINDS, NIH ZIA HS003029, and ZIA NS002946 (Z-H. Sheng).
NR 92
TC 7
Z9 7
U1 4
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-4189
EI 1460-2075
J9 EMBO J
JI Embo J.
PD AUG 4
PY 2015
VL 34
IS 15
BP 2059
EP 2077
DI 10.15252/embj.201591125
PG 19
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CO1XY
UT WOS:000358950800007
PM 26108535
ER

PT J
AU Hao, J
   de Renty, C
   Li, YM
   Xiao, HJ
   Kemp, MG
   Han, ZY
   DePamphilis, ML
   Zhu, WG
AF Hao, Jing
   de Renty, Christelle
   Li, Yongming
   Xiao, Haijie
   Kemp, Michael G.
   Han, Zhiyong
   DePamphilis, Melvin L.
   Zhu, Wenge
TI And-1 coordinates with Claspin for efficient Chk1 activation in response
   to replication stress
SO EMBO JOURNAL
LA English
DT Article
DE And-1; ATR; Chk1; Claspin; replication stress
ID SISTER-CHROMATID COHESION; DNA-POLYMERASE-ALPHA; XENOPUS EGG EXTRACTS;
   CHECKPOINT RESPONSE; HUMAN-CELLS; KINASE-ACTIVITIES; BINDING PROTEIN;
   S-PHASE; ATR; COMPLEX
AB The replisome is important for DNA replication checkpoint activation, but how specific components of the replisome coordinate with ATR to activate Chk1 in human cells remains largely unknown. Here, we demonstrate that And-1, a replisome component, acts together with ATR to activate Chk1. And-1 is phosphorylated at T826 by ATR following replication stress, and this phosphorylation is required for And-1 to accumulate at the damage sites, where And-1 promotes the interaction between Claspin and Chk1, thereby stimulating efficient Chk1 activation by ATR. Significantly, And-1 binds directly to ssDNA and facilitates the association of Claspin with ssDNA. Furthermore, And-1 associates with replication forks and is required for the recovery of stalled forks. These studies establish a novel ATR-And-1 axis as an important regulator for efficient Chk1 activation and reveal a novel mechanism of how the replisome regulates the replication checkpoint and genomic stability.
C1 [Hao, Jing; Li, Yongming; Xiao, Haijie; Han, Zhiyong; Zhu, Wenge] George Washington Univ, Sch Med, Dept Biochem & Mol Med, Washington, DC 20052 USA.
   [de Renty, Christelle; DePamphilis, Melvin L.] NICHHD, Bethesda, MD 20892 USA.
   [Kemp, Michael G.] Florida Inst Technol, Dept Biol Sci, Melbourne, FL 32901 USA.
RP Zhu, WG (reprint author), George Washington Univ, Sch Med, Dept Biochem & Mol Med, Washington, DC 20052 USA.
EM wz6812@gwu.edu
FU National Institutes of Health [CA177898, CA184717]; American Cancer
   Society [RSG-13-214-01-DMC]; NICHD/NINDS [2R24HD050846-06]; NICHD
   [5P30HD040677-10]; NIH NCATS [UL1RR031988]
FX We thank Drs. A. Dutta, J. Chen, E. Noguchi, and A. Sancar for reagents.
   This work was partially supported by funding from the National
   Institutes of Health (CA177898 and CA184717). Wenge Zhu was supported by
   a Research Scholar Grant, RSG-13-214-01-DMC, from the American Cancer
   Society. This work was partially supported by core grants NICHD/NINDS
   2R24HD050846-06 (National Center for Medical Rehabilitation Research),
   NICHD 5P30HD040677-10 (Intellectual and Developmental Disabilities
   Research Center), and NIH NCATS UL1RR031988 (CTSI-CN). The authors would
   like to thank Dr. Kristy J. Brown for her kind assistance in collection
   and processing of the mass spectrometry samples.
NR 59
TC 4
Z9 4
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-4189
EI 1460-2075
J9 EMBO J
JI Embo J.
PD AUG 4
PY 2015
VL 34
IS 15
BP 2096
EP 2110
DI 10.15252/embj.201488016
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CO1XY
UT WOS:000358950800009
PM 26082189
ER

PT J
AU Spronken, MI
   Short, KR
   Herfst, S
   Bestebroer, TM
   Vaes, VP
   van der Hoeven, B
   Koster, AJ
   Kremers, GJ
   Scott, DP
   Gultyaev, AP
   Sorell, EM
   de Graaf, M
   Barcena, M
   Rimmelzwaan, GF
   Fouchier, RA
AF Spronken, Monique I.
   Short, Kirsty R.
   Herfst, Sander
   Bestebroer, Theo M.
   Vaes, Vincent P.
   van der Hoeven, Barbara
   Koster, Abraham J.
   Kremers, Gert-Jan
   Scott, Dana P.
   Gultyaev, Alexander P.
   Sorell, Erin M.
   de Graaf, Miranda
   Barcena, Montserrat
   Rimmelzwaan, Guus F.
   Fouchier, Ron A.
TI Optimisations and Challenges Involved in the Creation of Various
   Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro
   and In Vivo Applications
SO PLOS ONE
LA English
DT Article
ID NEUTRALIZING ANTIBODIES; ELECTRON-MICROSCOPY; PACKAGING SIGNALS;
   REPORTER VIRUS; INFECTION; GENERATION; REPLICATION; EXPRESSION; VECTORS;
   PROTEIN
AB Bioluminescent and fluorescent influenza A viruses offer new opportunities to study influenza virus replication, tropism and pathogenesis. To date, several influenza A reporter viruses have been described. These strategies typically focused on a single reporter gene (either bioluminescent or fluorescent) in a single virus backbone. However, whilst bioluminescence is suited to in vivo imaging, fluorescent viruses are more appropriate for microscopy. Therefore, the ideal reporter virus varies depending on the experiment in question, and it is important that any reporter virus strategy can be adapted accordingly. Herein, a strategy was developed to create five different reporter viruses in a single virus backbone. Specifically, enhanced green fluorescent protein (eGFP), far-red fluorescent protein (fRFP), near-infrared fluorescent protein (iRFP), Gaussia luciferase (gLUC) and firefly luciferase (fLUC) were inserted into the PA gene segment of A/PR/8/34 (H1N1). This study provides a comprehensive characterisation of the effects of different reporter genes on influenza virus replication and reporter activity. In vivo reporter gene expression, in lung tissues, was only detected for eGFP, fRFP and gLUC expressing viruses. In vitro, the eGFP-expressing virus displayed the best reporter stability and could be used for correlative light electron microscopy (CLEM). This strategy was then used to create eGFP-expressing viruses consisting entirely of pandemic H1N1, highly pathogenic avian influenza (HPAI) H5N1 and H7N9. The HPAI H5N1 eGFP-expressing virus infected mice and reporter gene expression was
C1 [Spronken, Monique I.; Short, Kirsty R.; Herfst, Sander; Bestebroer, Theo M.; Vaes, Vincent P.; Gultyaev, Alexander P.; Sorell, Erin M.; de Graaf, Miranda; Rimmelzwaan, Guus F.; Fouchier, Ron A.] Erasmus MC, Dept Virosci, Rotterdam, Netherlands.
   [Short, Kirsty R.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [van der Hoeven, Barbara; Koster, Abraham J.; Barcena, Montserrat] Leiden Univ, Med Ctr, Sect Electron Microscopy, Dept Mol Cell Biol, Leiden, Netherlands.
   [Kremers, Gert-Jan] Erasmus Univ, Dept Pathol, Med Ctr, Erasmus Opt Imaging Ctr, NL-3000 DR Rotterdam, Netherlands.
   [Scott, Dana P.] NIAID, Rocky Mt Vet Branch, Div Intramural Res, NIH, Hamilton, MT USA.
   [Gultyaev, Alexander P.] Leiden Univ, Leiden Inst Adv Comp Sci, Leiden, Netherlands.
   [Sorell, Erin M.] George Washington Univ, Dept Hlth Policy & Management, Milken Inst Sch Publ Hlth, Washington, DC USA.
RP Fouchier, RA (reprint author), Erasmus MC, Dept Virosci, Rotterdam, Netherlands.
EM r.fouchier@erasmusmc.nl
RI Barcena, Montserrat/B-5823-2012; Fouchier, Ron/A-1911-2014
OI Barcena, Montserrat/0000-0002-7719-4443; Fouchier,
   Ron/0000-0001-8095-2869
FU NIAID/NIH [HHSN266200700010C, HSN272201400008C]; European Union
   [278976]; NHMRC CJ Martin post-doctoral fellowship [1054081];
   NWO-MEERVOUD grant [836.10.003]
FX RF is supported by NIAID/NIH contract HHSN266200700010C,
   HSN272201400008C and Framework Seven program ANTIGONE (278976) of the
   European Union. KRS is supported by an NHMRC CJ Martin post-doctoral
   fellowship (1054081). MB is supported by an NWO-MEERVOUD grant
   (836.10.003).
NR 54
TC 4
Z9 5
U1 2
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 4
PY 2015
VL 10
IS 8
AR e0133888
DI 10.1371/journal.pone.0133888
PG 30
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO1VB
UT WOS:000358942700027
PM 26241861
ER

PT J
AU Tieu, HV
   Liu, TY
   Hussen, S
   Connor, M
   Wang, L
   Buchbinder, S
   Wilton, L
   Gorbach, P
   Mayer, K
   Griffith, S
   Kelly, C
   Elharrar, V
   Phillips, G
   Cummings, V
   Koblin, B
   Latkin, C
AF Tieu, Hong-Van
   Liu, Ting-Yuan
   Hussen, Sophia
   Connor, Matthew
   Wang, Lei
   Buchbinder, Susan
   Wilton, Leo
   Gorbach, Pamina
   Mayer, Kenneth
   Griffith, Sam
   Kelly, Corey
   Elharrar, Vanessa
   Phillips, Gregory
   Cummings, Vanessa
   Koblin, Beryl
   Latkin, Carl
CA HPTN061
TI Sexual Networks and HIV Risk among Black Men Who Have Sex with Men in 6
   US Cities
SO PLOS ONE
LA English
DT Article
ID OLDER PARTNER SELECTION; AFRICAN-AMERICAN MEN; TRANSMITTED INFECTIONS;
   UNITED-STATES; TRANSMISSION; DISPARITIES; BEHAVIORS; METAANALYSIS;
   PATTERNS; HEALTH
AB Background
   Sexual networks may place U.S. Black men who have sex with men (MSM) at increased HIV risk.
   Methods
   Self-reported egocentric sexual network data from the prior six months were collected from 1,349 community-recruited Black MSM in HPTN 061, a multi-component HIV prevention intervention feasibility study. Sexual network composition, size, and density (extent to which members are having sex with one another) were compared by self-reported HIV serostatus and age of the men. GEE models assessed network and other factors associated with having a Black sex partner, having a partner with at least two age category difference (age difference between participant and partner of at least two age group categories), and having serodiscordant/serostatus unknown unprotected anal/vaginal intercourse (SDUI) in the last six months.
   Results
   Over half had exclusively Black partners in the last six months, 46% had a partner of at least two age category difference, 87% had <= 5 partners. Nearly 90% had sex partners who were also part of their social networks. Among HIV-negative men, not having anonymous/exchange/trade partners and lower density were associated with having a Black partner; larger sexual network size and having non-primary partners were associated with having a partner with at least two age category difference; and having anonymous/exchange/trade partners was associated with SDUI. Among HIV-positive men, not having non-primary partners was associated with having a Black partner; no sexual network characteristics were associated with having a partner with at least two age category difference and SDUI.
   Conclusions
   Black MSM sexual networks were relatively small and often overlapped with the social networks. Sexual risk was associated with having non-primary partners and larger network size. Network interventions that engage the social networks of Black MSM, such as interventions utilizing peer influence, should be developed to address stable partnerships, number of partners, and serostatus disclosure.
C1 [Tieu, Hong-Van; Koblin, Beryl] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA.
   [Tieu, Hong-Van] Columbia Univ, Dept Med, Med Ctr, Div Infect Dis, New York, NY USA.
   [Liu, Ting-Yuan; Connor, Matthew; Wang, Lei; Kelly, Corey] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Hussen, Sophia] Emory Sch Med, Div Infect Dis, Atlanta, GA USA.
   [Buchbinder, Susan] San Francisco Dept Publ Hlth, Bridge HIV, San Francisco, CA USA.
   [Wilton, Leo] SUNY Binghamton, Dept Human Dev, Binghamton, NY USA.
   [Wilton, Leo] Univ Johannesburg, Fac Humanities, Johannesburg, South Africa.
   [Gorbach, Pamina] Univ Calif Los Angeles, David Geffen Sch Med, Dept Epidemiol, Sch Publ Hlth,Div InfectiousDis, Los Angeles, CA 90095 USA.
   [Mayer, Kenneth] Fenway Community Hlth Ctr, Boston, MA USA.
   [Griffith, Sam] FHI 360, Res Triangle Pk, NC USA.
   [Elharrar, Vanessa] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
   [Phillips, Gregory] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Epidemiol & Biostat, Washington, DC USA.
   [Cummings, Vanessa] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Latkin, Carl] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Tieu, HV (reprint author), New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA.
EM htieu@nybloodcenter.org
OI Phillips II, Gregory/0000-0001-8396-1170
FU National Institute of Allergy and Infectious Disease (NIAID); National
   Institute on Drug Abuse (NIDA); National Institute of Mental Health
   (NIMH) [UM1 AI068619, UM1 AI068617, UM1 AI068613]; Fenway Institute
   Clinical Research Site (CRS): Harvard University CFAR [P30 AI060354];
   CTU for HIV Prevention and Microbicide Research [UM1 AI069480]; George
   Washington University CRS: District of Columbia Developmental CFAR [P30
   AI087714]; Harlem Prevention Center CRS and NY Blood Center/Union Square
   CRS: Columbia University CTU [5U01 AI069466]; ARRA [3U01 AI069466-03S1];
   Hope Clinic of the Emory Vaccine Center CRS; Ponce de Leon Center CRS:
   Emory University HIV/AIDS CTU [5U01 AI069418]; CFAR [P30 AI050409]; CTSA
   [UL1 RR025008]; San Francisco Vaccine and Prevention CRS: ARRA [3U01
   AI069496-03S1, 3U01 AI069496-03S2]; UCLA Vine Street CRS: UCLA
   Department of Medicine, Division of Infectious Diseases CTU [U01
   AI069424]
FX HPTN 061 grant support was provided by the National Institute of Allergy
   and Infectious Disease (NIAID), National Institute on Drug Abuse (NIDA)
   and National Institute of Mental Health (NIMH): Cooperative Agreements
   UM1 AI068619, UM1 AI068617, and UM1 AI068613. Additional site funding -
   Fenway Institute Clinical Research Site (CRS): Harvard University CFAR
   (P30 AI060354) and CTU for HIV Prevention and Microbicide Research (UM1
   AI069480); George Washington University CRS: District of Columbia
   Developmental CFAR (P30 AI087714); Harlem Prevention Center CRS and NY
   Blood Center/Union Square CRS: Columbia University CTU (5U01 AI069466)
   and ARRA funding (3U01 AI069466-03S1); Hope Clinic of the Emory Vaccine
   Center CRS and The Ponce de Leon Center CRS: Emory University HIV/AIDS
   CTU (5U01 AI069418), CFAR (P30 AI050409) and CTSA (UL1 RR025008); San
   Francisco Vaccine and Prevention CRS: ARRA funding (3U01 AI069496-03S1,
   3U01 AI069496-03S2); UCLA Vine Street CRS: UCLA Department of Medicine,
   Division of Infectious Diseases CTU (U01 AI069424). The funder had a
   role in the design of the study by providing input into the design. The
   funder did not have a role in the data collection and analysis, decision
   to publish, or preparation of the manuscript.
NR 65
TC 2
Z9 2
U1 2
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 4
PY 2015
VL 10
IS 8
AR e0134085
DI 10.1371/journal.pone.0134085
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO1VB
UT WOS:000358942700034
PM 26241742
ER

PT J
AU Fellahi, S
   El Harrak, M
   Ducatez, M
   Loutfi, C
   Koraichi, SI
   Kuhn, JH
   Khayi, S
   EL Houadfi, M
   Ennaji, MM
AF Fellahi, Siham
   EL Harrak, Mehdi
   Ducatez, Mariette
   Loutfi, Chafiqa
   Koraichi, Saad Ibn Souda
   Kuhn, Jens H.
   Khayi, Slimane
   EL Houadfi, Mohammed
   Ennaji, My Mustapha
TI Phylogenetic analysis of avian infectious bronchitis virus S1
   glycoprotein regions reveals emergence of a new genotype in Moroccan
   broiler chicken flocks
SO VIROLOGY JOURNAL
LA English
DT Article
DE Infectious bronchitis virus; Phylogenetic analysis; New genotype;
   Morocco
ID CORONAVIRUS-IBV; MOLECULAR CHARACTERIZATION; HYPERVARIABLE REGION; SPIKE
   GLYCOPROTEIN; AMINO-ACIDS; SEQUENCE; GENE; SEROTYPES; PROTEIN;
   IDENTIFICATION
AB Background: Infectious bronchitis virus (IBV), a major pathogen of commercial poultry flocks, circulates in the form of several serotypes/genotypes. Only a few amino-acid changes in the S1 subunit of wild-type IBVS proteins may result in mutants unaffected by current vaccines.
   Methods: Partial S1 gene sequences of 3 IBV isolates of the Moroccan Italy 02 genotype from vaccinated and unvaccinated broiler chicken flocks, located in southern and central regions of Morocco, were amplified by RT PCR, sequenced, and aligned for phylogenetic and amino-acid similarity analyses.
   Results: The three isolates were found genetically highly distant from known avian IBV based on partial sequences of their S1 genes: gammaCoV/chicken/Morocco/101/2011(IBV/ Morocco/01), gammaCoV/chicken/Morocco/130/2010 (IBV/Morocco/30), and gammaCoV/chicken/Morocco/138/2013 (IBV/Morocco/38), nucleotide sequence identities reached 89.5 % to 90.9 % among the three isolates. The deduced protein sequence identities ranged from 29.7 % (between IBV/ Morocco/38 and Egypt SCU-14/2013-1) to 78.2 % (between IBV/ Morocco/01 and Spain/05/866). Amino acid sequence comparison and phylogenetic analysis indicated the emergence of a new Moroccan genotype, clustering with regionally related isolates from Spain (Spain/05/866) and belonging to a new sub-genotype.
   Conclusion: Our sequencing results demonstrate a co-circulation of wild-type infectious bronchitis viruses in broiler chickens. These results justify permanent monitoring of circulating strains in order to rationally modify vaccination strategies to make them appropriate to the evolving field situation.
C1 [Fellahi, Siham; EL Houadfi, Mohammed] Inst Agron & Vet Hassan II, Dept Pathol & Sante Publ Vet, Unite Pathol Aviaire, Rabat 10000, Morocco.
   [EL Harrak, Mehdi; Loutfi, Chafiqa] Soc Prod Biol & Pharmaceut Vet, Rabat 10000, Morocco.
   [Ducatez, Mariette] INRA, Unite Mixte Rech Interact Hotes Agents Pathogenes, F-31076 Toulouse, France.
   [Ducatez, Mariette] Univ Toulouse, Inst Natl Polytech, Ecole Natl Vet Toulouse, Unite Mixte Rech Interact Hotes Agents Pathogenes, F-31076 Toulouse, France.
   [Koraichi, Saad Ibn Souda] Univ Sidi Mohamed Ben Abdellah, Lab Biotechnol Microbienne, Fes 30000, Morocco.
   [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
   [Khayi, Slimane] Univ Moulay Ismail, Genom Cellulaire & Tech Mol Invest, Meknes 50000, Morocco.
   [Ennaji, My Mustapha] Univ Hassan II Casablanca, ETB, Lab Virol Microbiol & Qual, Fac Sci & Tech, Mohammadia 20650, Morocco.
RP Ennaji, MM (reprint author), Univ Hassan II Casablanca, ETB, Lab Virol Microbiol & Qual, Fac Sci & Tech, Mohammadia 20650, Morocco.
EM m.ennaji@yahoo.fr
FU Battelle Memorial Institute's prime; US National Institute of Allergy
   and Infectious Diseases (NIAID) [HHSN272200700016I]
FX We thank Laura Bollinger (Integrated Research Facility at Fort Detrick)
   for providing Technical Writing Services in critically editing this
   manuscript on behalf of Battelle Memorial Institute. The content of this
   publication does not necessarily reflect the views or policies of the US
   Department of Health and Human Services (DHHS) or of the institutions
   and companies affiliated with the authors. This work was funded in part
   through Battelle Memorial Institute's prime contract with the US
   National Institute of Allergy and Infectious Diseases (NIAID) under
   Contract No. HHSN272200700016I. A subcontractor to Battelle Memorial
   Institute who performed this work is J.H.K., an employee of Tunnell
   Government Services, Inc.
NR 34
TC 0
Z9 0
U1 1
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD AUG 4
PY 2015
VL 12
AR 116
DI 10.1186/s12985-015-0347-8
PG 8
WC Virology
SC Virology
GA CO1FQ
UT WOS:000358900100003
PM 26239707
ER

PT J
AU Forlani, G
   Makarova, KS
   Ruszkowski, M
   Bertazzini, M
   Nocek, B
AF Forlani, Giuseppe
   Makarova, Kira S.
   Ruszkowski, Milosz
   Bertazzini, Michele
   Nocek, Boguslaw
TI Evolution of plant delta(1)-pyrroline-5-carboxylate reductases from
   phylogenetic and structural perspectives
SO FRONTIERS IN PLANT SCIENCE
LA English
DT Article
DE P5C reductase; phylogenetic analysis; 3-D structures of P5CRs; oligomer
   structure prediction; cofactor preference
ID PROTEIN-PROTEIN INTERACTIONS; PYRROLINE-5-CARBOXYLATE REDUCTASE; PROLINE
   BIOSYNTHESIS; STREPTOCOCCUS-PYOGENES; ESCHERICHIA-COLI; COFACTOR
   BINDING; P5C REDUCTASE; AMINO-ACID; PURIFICATION; SEQUENCE
AB Proline plays a crucial role in cell growth and stress responses, and its accumulation is essential for the tolerance of adverse environmental conditions in plants. Two routes are used to biosynthesize proline in plants. The main route uses glutamate as a precursor, while in the other route proline is derived from ornithine. The terminal step of both pathways, the conversion of delta(1)-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by P5C reductase (P5CR) using NADH or NADPH as a cofactor. Since P5CRs are important housekeeping enzymes, they are conserved across all domains of life and appear to be relatively unaffected throughout evolution. However, global analysis of these enzymes unveiled significant functional diversity in the preference for cofactors (NADPH vs. NADH), variation in metal dependence and the differences in the oligomeric state. In our study we investigated evolutionary patterns through phylogenetic and structural analysis of P5CR representatives from all kingdoms of life, with emphasis on the plant species. We also attempted to correlate local sequence/structure variation among the functionally and structurally characterized members of the family.
C1 [Forlani, Giuseppe; Bertazzini, Michele] Univ Ferrara, Dept Life Sci & Biotechnol, I-44100 Ferrara, Italy.
   [Makarova, Kira S.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
   [Ruszkowski, Milosz] NCI, Synchrotron Radiat Res Sect, Macromol Crystallog Lab, Argonne Natl Lab, Argonne, IL USA.
   [Nocek, Boguslaw] Argonne Natl Lab, Biosci Div, Argonne, IL 60439 USA.
RP Nocek, B (reprint author), Argonne Natl Lab, Biosci Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM bnocek@anl.gov
RI Forlani, Giuseppe/B-7869-2009
OI Forlani, Giuseppe/0000-0003-2598-5718
FU Intramural Research Program of the NCI, Center for Cancer Research
FX We are grateful to Rory Mulligan, Cathy Hatzos-Skintges, Magdalena
   Makowska-Grzyska, Jurek Osipiuk, and Zbyszek Dauter for their comments
   and critical reading of the manuscript. Project was partially supported
   by the Intramural Research Program of the NCI, Center for Cancer
   Research.
NR 70
TC 4
Z9 4
U1 4
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-462X
J9 FRONT PLANT SCI
JI Front. Plant Sci.
PD AUG 3
PY 2015
VL 6
AR 567
DI 10.3389/fpls.2015.00567
PG 15
WC Plant Sciences
SC Plant Sciences
GA CP5DJ
UT WOS:000359901200001
PM 26284089
ER

PT J
AU Oliver, VF
   Jaffe, AE
   Song, J
   Wang, GH
   Zhang, PW
   Branham, KE
   Swaroop, A
   Eberhart, CG
   Zack, DJ
   Qian, J
   Merbs, SL
AF Oliver, Verity F.
   Jaffe, Andrew E.
   Song, Jin
   Wang, Guohua
   Zhang, Pingwu
   Branham, Kari E.
   Swaroop, Anand
   Eberhart, Charles G.
   Zack, Donald J.
   Qian, Jiang
   Merbs, Shannath L.
TI Differential DNA methylation identified in the blood and retina of AMD
   patients
SO EPIGENETICS
LA English
DT Article
DE age-related macular degeneration; DNA methylation; genome-wide
   methylation; methyl-QTL; peripheral blood leukocytes; retina
ID EPIGENOME-WIDE ASSOCIATION; MACULAR DEGENERATION; GENE-EXPRESSION;
   IL17RC PROMOTER; SMOKING; DISEASE; GENOME; TSP50; CELLS; RISK
AB Age-related macular degeneration (AMD) is a major cause of blindness in the western world. While genetic studies have linked both common and rare variants in genes involved in regulation of the complement system to increased risk of development of AMD, environmental factors, such as smoking and nutrition, can also significantly affect the risk of developing the disease and the rate of disease progression. Since epigenetics has been implicated in mediating, in part, the disease risk associated with some environmental factors, we investigated a possible epigenetic contribution to AMD. We performed genome-wide DNA methylation profiling of blood from AMD patients and controls. No differential methylation site reached genome-wide significance; however, when epigenetic changes in and around known GWAS-defined AMD risk loci were explored, we found small but significant DNA methylation differences in the blood of neovascular AMD patients near age-related maculopathy susceptibility 2 (ARMS2), a top-ranked GWAS locus preferentially associated with neovascular AMD. The methylation level of one of the CpG sites significantly correlated with the genotype of the risk SNP rs10490924, suggesting a possible epigenetic mechanism of risk. Integrating genome-wide DNA methylation analysis of retina samples with and without AMD together with blood samples, we further identified a consistent, replicable change in DNA methylation in the promoter region of protease serine 50 (PRSS50). These methylation changes may identify sites in novel genes that are susceptible to non-genetic factors known to contribute to AMD development and progression.
C1 [Oliver, Verity F.; Song, Jin; Wang, Guohua; Zhang, Pingwu; Eberhart, Charles G.; Zack, Donald J.; Qian, Jiang; Merbs, Shannath L.] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA.
   [Jaffe, Andrew E.] Lieber Inst Brain Dev, Baltimore, MD USA.
   [Jaffe, Andrew E.] Johns Hopkins Univ, Johns Hopkins Computat Biol Ctr, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA.
   [Jaffe, Andrew E.] Johns Hopkins Univ, Johns Hopkins Computat Biol Ctr, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA.
   [Branham, Kari E.] Univ Michigan, Dept Ophthalmol & Visual Sci, Kellogg Eye Ctr, Ann Arbor, MI 48109 USA.
   [Swaroop, Anand] NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA.
   [Eberhart, Charles G.; Merbs, Shannath L.] Johns Hopkins Univ, Sch Med, Oncol, Baltimore, MD USA.
   [Eberhart, Charles G.] Johns Hopkins Univ, Sch Med, Pathol, Baltimore, MD USA.
   [Zack, Donald J.] Johns Hopkins Univ, Sch Med, Mol Biol & Genet, Baltimore, MD USA.
   [Zack, Donald J.] Johns Hopkins Univ, Sch Med, Neurosci, Baltimore, MD USA.
   [Zack, Donald J.] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD USA.
   [Zack, Donald J.] Inst Vis, Paris, France.
RP Qian, J (reprint author), Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA.
EM jiang.qian@jhmi.edu; smerbs@jhmi.edu
RI Jaffe, Andrew/L-3089-2016; 
OI Jaffe, Andrew/0000-0001-6886-1454; Swaroop, Anand/0000-0002-1975-1141
FU National Institutes of Health [R01EY020406, R01EY023188, R01EY024580];
   National Eye Institute [P30EY001765, EY016862]; Foundation Fighting
   Blindness; generosity of Agnes Nixon; Center for Inherited Disease
   Research (CIDR) through the NEI grant [X01HG006605]
FX This work was supported by the National Institutes of Health
   [R01EY020406 to SLM, R01EY023188 to SLM and JQ, R01EY024580 to JQ]; the
   National Eye Institute Core Grant [P30EY001765]; the Intramural Research
   Program of the National Eye Institute (to AS); Foundation Fighting
   Blindness (to KEB); the generosity of Agnes Nixon (SLM). The collection
   of the Michigan AMD-MMAP cohort was funded by the National Eye Institute
   [EY016862 to AS]. Illumina Human Methylation 450K profiling was
   performed by the Center for Inherited Disease Research (CIDR) through
   the NEI grant X01HG006605.
NR 41
TC 3
Z9 5
U1 0
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1559-2294
EI 1559-2308
J9 EPIGENETICS-US
JI Epigenetics
PD AUG 3
PY 2015
VL 10
IS 8
BP 698
EP 707
DI 10.1080/15592294.2015.1060388
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CP1AH
UT WOS:000359607700004
PM 26067391
ER

PT J
AU Li, JY
   Valentin, A
   Beach, RK
   Alicea, C
   Felber, BK
   Pavlakis, GN
AF Li, Jinyao
   Valentin, Antonio
   Beach, Rachel Kelly
   Alicea, Candido
   Felber, Barbara K.
   Pavlakis, George N.
TI DNA is an efficient booster of dendritic cell-based vaccine
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article; Proceedings Paper
CT DNA Vaccine 2014 Conference
CY JUL 21-23, 2014
CL San Diego, CA
DE DNA vaccine; mice; dendritic cells; peptide
ID CANCER-IMMUNOTHERAPY; IMMUNE-RESPONSES; ELECTROPORATION; IMMUNIZATION;
   MATURATION; MELANOMA; DELIVERY; HIV-1; DIFFERENTIATION; STRATEGIES
AB DC-based therapeutic vaccines as a promising strategy against chronic infections and cancer have been validated in several clinical trials. However, DC-based vaccines are complex and require many in vitro manipulations, which makes this a personalized and expensive therapeutic approach. In contrast, DNA-based vaccines have many practical advantages including simplicity, low cost of manufacturing and potent immunogenicity already proven in non-human primates and humans. In this study, we explored whether DC-based vaccines can be simplified by the addition of plasmid DNA as prime or boost to achieve robust CD8-mediated immune responses. We compared the cellular immunity induced in BALB/c and C57BL/6mice by DC vaccines, loaded either with peptides or optimized SIV Env DNA, and plasmid DNA-based vaccines delivered by electroporation (EP). We found that mature DC loaded with peptides (P-mDC) induced the highest CD8(+) T cell responses in both strains of mice, but those responses were significantly higher in the C57BL/6model. A heterologous prime-boost strategy (P-DC prime-DNA boost) induced CD8(+) T cell responses similar to those obtained by the P-DC vaccine. Importantly, this strategy elicited robust polyfunctional T cells as well as highest antigen-specific central memory CD8+ T cells in C57BL/6mice, suggesting long-term memory responses. These results indicate that a DC-based vaccine in combination with DNA in a heterologous DC prime-DNA boost strategy has potential as a repeatedly administered vaccine.
C1 [Li, Jinyao; Valentin, Antonio; Beach, Rachel Kelly; Pavlakis, George N.] NCI, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
   [Beach, Rachel Kelly; Alicea, Candido; Felber, Barbara K.] NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
RP Pavlakis, GN (reprint author), NCI, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
EM george.pavlakis@nih.gov
FU Intramural Research Program of the National Cancer Institute, National
   Institutes of Health (NCI/NIH)
FX This work was supported by the Intramural Research Program of the
   National Cancer Institute, National Institutes of Health (NCI/NIH) (BKF,
   GNP).
NR 36
TC 1
Z9 1
U1 3
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD AUG 3
PY 2015
VL 11
IS 8
BP 1927
EP 1935
DI 10.1080/21645515.2015.1020265
PG 9
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA CP1AQ
UT WOS:000359608600017
PM 26125100
ER

PT J
AU Valentin, A
   Li, JY
   Rosati, M
   Kulkarni, V
   Patel, V
   Jalah, R
   Alicea, C
   Reed, S
   Sardesai, N
   Berkower, I
   Pavlakis, GN
   Felber, BK
AF Valentin, Antonio
   Li, Jinyao
   Rosati, Margherita
   Kulkarni, Viraj
   Patel, Vainav
   Jalah, Rashmi
   Alicea, Candido
   Reed, Steven
   Sardesai, Niranjan
   Berkower, Ira
   Pavlakis, George N.
   Felber, Barbara K.
TI Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA
   vaccinated macaques
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article; Proceedings Paper
CT DNA Vaccine 2014 Conference
CY JUL 21-23, 2014
CL San Diego, CA
DE cellular immunity; DNA electroporation; HIV vaccines; humoral immunity;
   vaccine optimization
ID IMMUNODEFICIENCY-VIRUS TYPE-1; RHESUS MACAQUES; CO-IMMUNIZATION;
   SIVMAC251 CHALLENGE; PLASMID IL-12; VIRAL LOAD; T-CELLS; RESPONSES;
   ELECTROPORATION; INTERLEUKIN-12
AB The induction of a balanced immune response targeting the major structural proteins, Gag and Env of HIV, is important for the development of an efficacious vaccine. The use of DNA plasmids expressing different antigens offers the opportunity to test in a controlled manner the influence of different vaccine components on the magnitude and distribution of the vaccine-induced cellular and humoral immune responses. Here, we show that increasing amounts of env DNA results in greatly enhanced Env antibody titers without significantly affecting the levels of anti-Env cellular immune responses. Co-immunization with Env protein further increased antibody levels, indicating that vaccination with DNA only is not sufficient for eliciting maximal humoral responses against Env. In contrast, under high env:gag DNA plasmid ratio, the development of Gag cellular responses was significantly reduced by either SIV or HIV Env, whereas Gag humoral responses were not affected. Our data indicate that a balanced ratio of the 2 key HIV/SIV vaccine components, Gag and Env, is important to avoid immunological interference and to achieve both maximal humoral responses against Env to prevent virus acquisition and maximal cytotoxic T cell responses against Gag to prevent virus spread.
C1 [Valentin, Antonio; Li, Jinyao; Rosati, Margherita; Patel, Vainav; Pavlakis, George N.] NCI, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
   [Kulkarni, Viraj; Jalah, Rashmi; Alicea, Candido; Felber, Barbara K.] NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
   [Reed, Steven] Infect Dis Res Inst, Seattle, WA USA.
   [Sardesai, Niranjan] Inovio Pharmaceut, Plymouth Meeting, PA USA.
   [Berkower, Ira] US FDA, Lab Immunoregulat, Div Viral Prod, Off Vaccines,Ctr Biol, Silver Spring, MD USA.
RP Felber, BK (reprint author), NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21701 USA.
EM Barbara.felber@nih.gov
FU Intramural Research Program of the National Cancer Institute, National
   Institutes of Health (NCI/NIH); Bill and Melinda Gates Foundation
   [42387]
FX This work was supported in part by the Intramural Research Program of
   the National Cancer Institute, National Institutes of Health (NCI/NIH)
   (BKF, GNP), and Bill and Melinda Gates Foundation Grant #42387 (SGR).
NR 43
TC 1
Z9 1
U1 1
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD AUG 3
PY 2015
VL 11
IS 8
BP 2005
EP 2011
DI 10.1080/21645515.2015.1016671
PG 7
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA CP1AQ
UT WOS:000359608600025
PM 26125521
ER

PT J
AU Nezich, CL
   Wang, CX
   Fogel, AI
   Youle, RJ
AF Nezich, Catherine L.
   Wang, Chunxin
   Fogel, Adam I.
   Youle, Richard J.
TI MiT/TFE transcription factors are activated during mitophagy downstream
   of Parkin and Atg5
SO JOURNAL OF CELL BIOLOGY
LA English
DT Article
ID ACETYL-COA CARBOXYLASE; P70 S6 KINASE; LYSOSOMAL BIOGENESIS;
   AUTOPHAGOSOME FORMATION; PROTEIN-KINASE; MITOCHONDRIAL DEPOLARIZATION;
   CELLULAR CLEARANCE; REGULATE AUTOPHAGY; FACTOR EB; IN-VIVO
AB The kinase PINK1 and ubiquitin ligase Parkin can regulate the selective elimination of damaged mitochondria through autophagy (mitophagy). Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in this process. We show that during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1- and Parkin-dependent manner. MITF and TFE3, homologues of TFEB belonging to the same microphthalmia/transcription factor E (MiT/TFE) family, are similarly regulated during mitophagy. Unlike TFEB translocation after starvation-induced mammalian target of rapamycin complex 1 inhibition, Parkin-mediated TFEB relocalization required At99A and At95 activity. However, constitutively active Rag guanosine triphosphatases prevented TFEB translocation during mitophagy, suggesting cross talk between these two MiT/TFE activation pathways. Analysis of clustered regularly interspaced short palindromic repeats generated TFEB/MITF/TFE3/TFEC single, double, and triple knockout cell lines revealed that these proteins partly facilitate Parkin-mediated mitochondrial clearance. These results illuminate a pathway leading to MiT/TFE transcription factor activation, distinct from starvation-induced autophagy, which occurs during mitophagy.
C1 [Nezich, Catherine L.; Wang, Chunxin; Fogel, Adam I.; Youle, Richard J.] NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
RP Youle, RJ (reprint author), NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA.
EM youler@ninds.nih.gov
RI Wang, Chunxin/B-9312-2016; di Ronza, Alberto/H-7674-2016
OI Wang, Chunxin/0000-0001-6015-6806; di Ronza, Alberto/0000-0002-9813-5143
FU National Institute of Neurological Disorders and Stroke intramural
   program
FX This work was supported by the National Institute of Neurological
   Disorders and Stroke intramural program.
NR 77
TC 24
Z9 25
U1 3
U2 12
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA
SN 0021-9525
EI 1540-8140
J9 J CELL BIOL
JI J. Cell Biol.
PD AUG 3
PY 2015
VL 210
IS 3
BP 435
EP 450
DI 10.1083/jcb.201501002
PG 16
WC Cell Biology
SC Cell Biology
GA CO5ES
UT WOS:000359183000007
PM 26240184
ER

PT J
AU Burman, B
   Misteli, T
   Pegoraro, G
AF Burman, Bharat
   Misteli, Tom
   Pegoraro, Gianluca
TI Quantitative detection of rare interphase chromosome breaks and
   translocations by high-throughput imaging
SO GENOME BIOLOGY
LA English
DT Article
ID LARGE-CELL LYMPHOMA; IN-SITU HYBRIDIZATION; ANAPLASTIC LYMPHOMA;
   SEQUENCING REVEALS; GENE FUSIONS; REARRANGEMENTS; ABNORMALITIES;
   MECHANISMS; MICROSCOPY; CANCER
AB We report a method for the sensitive detection of rare chromosome breaks and translocations in interphase cells. HiBA-FISH (High-throughput break-apart FISH) combines high-throughput imaging with the measurement of the spatial separation of FISH probes flanking target genome regions of interest. As proof-of-principle, we apply hiBA-FISH to detect with high sensitivity and specificity rare chromosome breaks and translocations in the anaplastic large cell lymphoma breakpoint regions of NPM1 and ALK. This method complements existing approaches to detect translocations by overcoming the need for precise knowledge of translocation breakpoints and it extends traditional FISH by its quantitative nature.
C1 [Burman, Bharat; Misteli, Tom] NCI, Cell Biol Genomes, NIH, Bethesda, MD 20892 USA.
   [Burman, Bharat] Tufts Univ, Sackler Sch Biomed Sci, Program Cell Mol & Dev Biol, Boston, MA 02111 USA.
   [Pegoraro, Gianluca] NCI, High Throughput Imaging Facil, NIH, Bethesda, MD 20892 USA.
RP Misteli, T (reprint author), NCI, Cell Biol Genomes, NIH, Bethesda, MD 20892 USA.
EM mistelit@mail.nih.gov; gianluca.pegoraro@nih.gov
OI Pegoraro, Gianluca/0000-0003-2843-9464
FU Intramural Research Program of the National Institutes of Health (NIH),
   NCI, Center for Cancer Research; HHMI-NIH
FX We thank members of the Misteli Lab for helpful feedback. This research
   was supported by the Intramural Research Program of the National
   Institutes of Health (NIH), NCI, Center for Cancer Research, and by a
   HHMI-NIH fellowship to BB.
NR 26
TC 4
Z9 4
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-6906
EI 1474-760X
J9 GENOME BIOL
JI Genome Biol.
PD AUG 3
PY 2015
VL 16
AR 146
DI 10.1186/s13059-015-0718-x
PG 14
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CN9JL
UT WOS:000358763000001
PM 26313373
ER

PT J
AU Sjuvarsson, E
   Marquez, VE
   Eriksson, S
AF Sjuvarsson, Elena
   Marquez, Victor E.
   Eriksson, Staffan
TI Selective Phosphorylation of South and North-Cytidine and Adenosine
   Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases
   Correlates with Their Growth Inhibitory Effects on Cultured Cells
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article
DE nucleoside and nucleotide kinases; mechanism of action studies; Modified
   nucleosides
ID HUMAN DEOXYCYTIDINE KINASE; CELLULAR DEOXYRIBONUCLEOSIDE KINASES;
   MITOCHONDRIAL DEOXYGUANOSINE KINASE; SUGAR RING CONFORMATION; SUBSTRATE
   SPECIFICITIES; CARBOCYCLIC THYMIDINE; ANALOG MONOPHOSPHATES;
   BIOLOGICAL-ACTIVITY; PURINE NUCLEOSIDES; DIPHOSPHATE KINASE
AB Here bicyclo[3.1.0]hexane locked deoxycytidine (S-MCdC, N-MCdC), and deoxyadenosine analogs (S-MCdA and N-MCdA) were examined as substrates for purified preparations of human deoxynucleoside kinases: dCK, dGK, TK2, TK1, the ribonucleoside kinase UCK2, two NMP kinases (CMPK1, TMPK) and a NDP kinase.
   dCK can be important for the first step of phosphorylation of S-MCdC in cells, but S-MCdCMP was not a substrate for CMPK1, TMPK, or NDPK.
   dCK and dGK had a preference for the S-MCdA whereas N-MCdA was not a substrate for dCK, TK1, UCK2, TK2, dGK nucleoside kinases. The cell growth experiments suggested that N-MCdC and S-MCdA could be activated in cells by cellular kinases so that a triphosphate metabolite was formed.
   List of abbreviations: ddC, 2 ', 3 '-didioxycytosine, Zalcitabine; 3TC, beta-L-(-)-2 ',3 '-dideoxy-3 '-thiacytidine, Lamivudine; CdA, 2-cloro-2 '-deoxyadenosine, Cladribine; AraA, 9-beta-D-arabinofuranosyladenine; hCNT 1-3, human Concentrative Nucleoside Transporter type 1, 2 and 3; hENT 1-4, human Equilibrative Nucleoside Transporter type 1, 2, 3, and 4.
C1 [Sjuvarsson, Elena; Eriksson, Staffan] Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, VHC, S-75651 Uppsala, Sweden.
   [Marquez, Victor E.] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21701 USA.
RP Sjuvarsson, E (reprint author), Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, VHC, Almas Alle 4c, S-75651 Uppsala, Sweden.
EM elena.sjuvarsson@slu.se
FU Swedish Research Council; National Institutes of Health, National Cancer
   Institute
FX This study was supported by the Swedish Research Council and in part by
   the National Institutes of Health, National Cancer Institute.
NR 51
TC 2
Z9 2
U1 1
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PD AUG 3
PY 2015
VL 34
IS 8
BP 544
EP 564
DI 10.1080/15257770.2015.1031248
PG 21
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CM8GJ
UT WOS:000357936300002
PM 26167664
ER

PT J
AU Imoto, S
   Kohgo, S
   Tokuda, R
   Kumamoto, H
   Aoki, M
   Amano, M
   Kuwata-Higashi, N
   Mitsuya, H
   Haraguchi, K
AF Imoto, Shuhei
   Kohgo, Satoru
   Tokuda, Ryoh
   Kumamoto, Hiroki
   Aoki, Manabu
   Amano, Masayuki
   Kuwata-Higashi, Nobuyo
   Mitsuya, Hiroaki
   Haraguchi, Kazuhiro
TI Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid
   Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine
   Nucleosides and Their Monophosphate Derivatives
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article
DE adefovir; acyclonucleoside; Nucleoside; anti-HBV activity; pro-drug;
   hybrid; nucleoside phosphonate; entecavir
ID HEPATITIS-B-VIRUS; ANALOGS; POTENT
AB Exomethylene acycloguanine nucleosides 4, 6 and its monophosphate derivatives 5, 7, and 8 have been synthesized. Mitsunobu-type coupling of 2-N-acetyl-6-O-diphenylcarbamoylguanine (11) with primary alcohols proceeded regioselectively to furnish the desired N-9-substituted products in moderate yield. Evaluation of 4-8 for anti-HBV activity in HepG2 cells revealed that the phosphonate derivative 8 was found to exhibit moderated activity (EC50 value of 0.29 mu M), but cytotoxicity (CC50 value of 39 mu M) against the host cells was also observed.
C1 [Imoto, Shuhei; Tokuda, Ryoh] Sojo Univ, Fac Pharmaceut Sci, Nishi Ku, Kumamoto, Japan.
   [Kohgo, Satoru; Haraguchi, Kazuhiro] Nihon Pharmaceut Univ, Dept Pharmaceut Sci, Ina, Saitama 3620806, Japan.
   [Kohgo, Satoru; Mitsuya, Hiroaki] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Shinju Ku, Tokyo, Japan.
   [Kumamoto, Hiroki] Showa Univ, Sch Pharm, Shinagawa Ku, Tokyo, Japan.
   [Aoki, Manabu] Kumamoto Hlth Sci Univ, Dept Med Technol, Kumamoto, Japan.
   [Amano, Masayuki; Kuwata-Higashi, Nobuyo; Mitsuya, Hiroaki] Kumamoto Univ, Sch Med, Dept Infect Dis, Kumamoto 860, Japan.
   [Amano, Masayuki; Kuwata-Higashi, Nobuyo; Mitsuya, Hiroaki] Kumamoto Univ, Sch Med, Dept Hematol, Kumamoto 860, Japan.
   [Mitsuya, Hiroaki] NCI, Expt Retrovirol Sect, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA.
RP Haraguchi, K (reprint author), Nihon Pharmaceut Univ, Dept Pharmaceut Sci, 10281 Komuro, Ina, Saitama 3620806, Japan.
EM harakazu@nichiyaku.ac.jp
RI Amano, Masayuki/N-7407-2016
OI Amano, Masayuki/0000-0003-0516-9502
FU Health and Labor Sciences Research Grant [Practical Research on
   Hepatitis (Research on the innovative development and the practical
   application of new drugs for hepatitis B)]
FX Financial support from a Health and Labor Sciences Research Grant
   [Practical Research on Hepatitis (Research on the innovative development
   and the practical application of new drugs for hepatitis B)] is
   gratefully acknowledged.
NR 14
TC 0
Z9 0
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PD AUG 3
PY 2015
VL 34
IS 8
BP 590
EP 602
DI 10.1080/15257770.2015.1037456
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CM8GJ
UT WOS:000357936300005
PM 26167667
ER

PT J
AU Anizan, S
   Huestis, MA
AF Anizan, Sebastien
   Huestis, Marilyn A.
TI The potential role of oral fluid in anti-doping testing
SO BIOCHIMICA CLINICA
LA Italian
DT Article
ID CHROMATOGRAPHY-MASS-SPECTROMETRY; ATHLETE BIOLOGICAL PASSPORT;
   CONTROLLED SMOKED CANNABIS; GROWTH-FACTOR-I; HUMAN URINE; ENDOGENOUS
   STEROIDS; SALIVARY TESTOSTERONE; SERUM TESTOSTERONE; DETECTION TIMES;
   METABOLITES
AB Currently, urine and blood are the only matrices authorized for antidoping testing by the World Anti-Doping Agency (WADA). Although the usefulness of urine and blood is proven, issues remain for monitoring some drug classes and for drugs prohibited only in competition. The alternative matrix oral fluid (OF) may offer solutions to some of these issues. OF collection is easy, noninvasive, and sex neutral and is directly observed, limiting potential adulteration, a major problem for urine testing. OF is used to monitor drug intake in workplace, clinical toxicology, criminal justice, and driving under the influence of drugs programs and potentially could complement urine and blood for antidoping testing in sports. This review outlines the present state of knowledge and the advantages and limitations of OF testing for each of the WADA drug classes and the research needed to advance OF testing as a viable alternative for antidoping testing. Doping agents are either prohibited at all times or prohibited in competition only. Few OF data from controlled drug administration studies are available for substances banned at all times, whereas for some agents prohibited only in competition, sufficient data may be available to suggest appropriate analytes and cutoffs (analytical threshold concentrations) to identify recent drug use. Additional research is needed to characterize the disposition of many banned substances into OF; OF collection methods and doping agent stability in OF also require investigation to allow the accurate interpretation of OF tests for antidoping monitoring.
C1 [Anizan, Sebastien; Huestis, Marilyn A.] NIDA, Chem & Drug Metab, Intramural Res Program, NIH, Baltimore, MD USA.
RP Anizan, S (reprint author), NIDA, Chem & Drug Metab, Intramural Res Program, NIH, Baltimore, MD USA.
NR 78
TC 0
Z9 0
U1 4
U2 4
PU ITALIAN SOC CLINICAL BIOCHEMISTRY
PI MILAN
PA VIA C FARINI, 81, MILAN, 20159, ITALY
SN 0393-0564
J9 BIOCHIM CLIN
JI Biochim. Clin.
PD AUG
PY 2015
VL 39
IS 4
BP 281
EP 300
PG 20
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA DM7SV
UT WOS:000376561200009
ER

PT J
AU Varoquaux, A
   le Fur, Y
   Imperiale, A
   Reyre, A
   Montava, M
   Fakhry, N
   Namer, IJ
   Moulin, G
   Pacak, K
   Guye, M
   Taieb, D
AF Varoquaux, Arthur
   le Fur, Yann
   Imperiale, Alessio
   Reyre, Antony
   Montava, Marion
   Fakhry, Nicolas
   Namer, Izzie-Jacques
   Moulin, Guy
   Pacak, Karel
   Guye, Maxime
   Taieb, David
TI Magnetic resonance spectroscopy of paragangliomas: new insights into in
   vivo metabolomics
SO ENDOCRINE-RELATED CANCER
LA English
DT Article
DE MR-spectroscopy; paraganglioma; positron-emission tomography;
   metabolomics
ID PROTON MR SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; NECK
   PARAGANGLIOMAS; INITIAL-EXPERIENCE; GERMLINE MUTATIONS; IMAGING DATA;
   HEAD; PHEOCHROMOCYTOMAS; SUCCINATE; CANCER
AB Paragangliomas (PGLs) can be associated with mutations in genes of the tricarboxylic acid(TCA) cycle. Succinate dehydrogenase (SDHx) mutations are the prime examples of genetically determined TCA cycle defects with accumulation of succinate. Succinate, which acts as an oncometabolite, can be detected by ex vivo metabolomics approaches. The aim of this study was to evaluate the potential role of proton magnetic resonance (MR) spectroscopy (H-1-MRS) for identifying SDHx-related PGLs in vivo and noninvasively. Eight patients were prospectively evaluated with single voxel H-1-MRS. MR spectra from eight tumors (four SDHx-related PGLs, two sporadic PGLs, one cervical schwannoma, and one cervical neurofibroma) were acquired and interpreted qualitatively. Compared to other tumors, a succinate resonance peak was detected only in SDHx-related tumor patients. Spectra quality was considered good in three cases, medium in two cases, poor in two cases, and uninterpretable in the latter case. Smaller lesions had lower spectra quality compared to larger lesions. Jugular PGLs also exhibited a poorer spectra quality compared to other locations. H-1-MRS has always been challenging in terms of its technical requisites. This is even more true for the evaluation of head and neck tumors. However, H-1-MRS might be added to the classical MR sequences for metabolomic characterization of PGLs. In vivo detection of succinate might guide genetic testing, characterize SDHx variants of unknown significance (in the absence of available tumor sample), and even optimize a selection of appropriate therapies.
C1 [Varoquaux, Arthur; Reyre, Antony; Moulin, Guy; Guye, Maxime] Aix Marseille Univ, La Timone Univ Hosp, Dept Med Imaging, F-13385 Marseille, France.
   [le Fur, Yann; Guye, Maxime] Aix Marseille Univ, CNRS, CRMBM, UMR 7339, F-13385 Marseille, France.
   [Imperiale, Alessio; Namer, Izzie-Jacques] Univ Hosp Strasbourg, Dept Biophys & Nucl Med, Strasbourg, France.
   [Imperiale, Alessio; Namer, Izzie-Jacques] Univ Strasbourg, CNRS, Fac Med, ICube,UMR 7357, Strasbourg, France.
   [Imperiale, Alessio; Namer, Izzie-Jacques] FMTS, Strasbourg, France.
   [Montava, Marion] Aix Marseille Univ, North Hosp, Dept Otorhinolaryngol Head & Neck Surg, F-13385 Marseille, France.
   [Fakhry, Nicolas] Aix Marseille Univ, La Timone Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, F-13385 Marseille, France.
   [Pacak, Karel] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Taieb, David] Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, F-13385 Marseille, France.
   [Taieb, David] Aix Marseille Univ, La Timone Univ Hosp, European Ctr Res Med Imaging, Biophys & Nucl Med, F-13385 Marseille, France.
   [Taieb, David] INSERM, Marseille Cancerol Res Ctr, Inst Paoli Calmettes, UMR1068, F-13258 Marseille, France.
RP Taieb, D (reprint author), Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, F-13385 Marseille, France.
EM VAROQUAUX@ap-hm.fr; david.taieb@ap-hm.fr
FU Intramural NIH HHS [ZIA HD008735-14]
NR 48
TC 4
Z9 4
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1351-0088
EI 1479-6821
J9 ENDOCR-RELAT CANCER
JI Endocr.-Relat. Cancer
PD AUG
PY 2015
VL 22
IS 4
BP M1
EP M8
DI 10.1530/ERC-15-0246
PG 8
WC Oncology; Endocrinology & Metabolism
SC Oncology; Endocrinology & Metabolism
GA DJ0LX
UT WOS:000373896400002
PM 26115958
ER

PT J
AU Castinetti, F
   Kroiss, A
   Kumar, R
   Pacak, K
   Taieb, D
AF Castinetti, Frederic
   Kroiss, Alexander
   Kumar, Rakesh
   Pacak, Karel
   Taieb, David
TI Imaging and imaging-based treatment of pheochromocytoma and
   paraganglioma
SO ENDOCRINE-RELATED CANCER
LA English
DT Review
DE positron-emission tomography; gallium radioisotopes; somatostatin;
   F-18-DOPA; F-18-FDG
ID POSITRON-EMISSION-TOMOGRAPHY; RECEPTOR RADIONUCLIDE THERAPY; NECK
   PARAGANGLIOMAS; MALIGNANT PHEOCHROMOCYTOMAS;
   FUNCTIONAL-CHARACTERIZATION; EXTRAADRENAL PARAGANGLIOMA;
   URINARY-EXCRETION; I-123-MIBG SPECT; F-18-FDG PET/CT; MR-ANGIOGRAPHY
AB Although anatomic imaging to assess the precise localization of pheochromocytomas/paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these tumors, functional imaging is becoming an inseparable portion of the imaging algorithm for these tumors. This review article presents applications of the most up-to-date functional imaging modalities and image-based treatment to PHEOs/PGLs patients. Functional imaging techniques provide whole-body localization (number of tumors present along with metastatic deposits) together with genetic-specific imaging approaches to PHEOs/PGLs, thus enabling highly specific and sensitive PHEO/PGL detection and delineation that now greatly impact the management of patients. Radionuclide imaging techniques also play a crucial role in the prediction of possible radioactive treatment options for PHEO/PGL. In contrast to previous imaging algorithms used for either assessement of these patients or their follow-up, endocrinologists, surgeons, oncologists, pediatricians, and other specialists require functional imaging before any therapeutic plan is outlined to the patient, and follow-up, especially in patients with metastatic disease, is based on the periodic use of functional imaging, often reducing or substituting for anatomical imaging. In similar specific indications, this will be further powered by using PET/MR in the assessment of these tumors. In the near future, it is expected that PHEO/PGL patients will benefit even more from an assessement of the functional characteristics of these tumors and new imaging-based treatment options. Finally, due to the use of new targeting moieties, gene-targeted radiotherapeutics and nanobodies-based theranostic approaches are expected to become a reality in the near future.
C1 [Castinetti, Frederic] Aix Marseille Univ, La Timone Univ Hosp, Dept Endocrinol, F-13385 Marseille, France.
   [Kroiss, Alexander] Med Univ Innsbruck, Dept Biophys & Nucl Med, A-6020 Innsbruck, Austria.
   [Kumar, Rakesh] All India Inst Med Sci, Dept Nucl Med, Diagnost Nucl Med Div, New Delhi, India.
   [Pacak, Karel] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
   [Taieb, David] Aix Marseille Univ, La Timone Univ Hosp, European Ctr Res Med Imaging CERIMED, Dept Nucl Med, F-13385 Marseille, France.
   [Taieb, David] INSERM, Marseille Cancerol Res Ctr, Inst Paoli Calmettes, UMR1068, F-13258 Marseille, France.
RP Taieb, D (reprint author), Aix Marseille Univ, La Timone Univ Hosp, European Ctr Res Med Imaging CERIMED, Dept Nucl Med, F-13385 Marseille, France.
EM david.taieb@ap-hm.fr
NR 59
TC 10
Z9 10
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1351-0088
EI 1479-6821
J9 ENDOCR-RELAT CANCER
JI Endocr.-Relat. Cancer
PD AUG
PY 2015
VL 22
IS 4
BP T135
EP T145
DI 10.1530/ERC-15-0175
PG 11
WC Oncology; Endocrinology & Metabolism
SC Oncology; Endocrinology & Metabolism
GA DJ0LX
UT WOS:000373896400006
PM 26045470
ER

PT J
AU O'Toole, SM
   Denes, J
   Robledo, M
   Stratakis, CA
   Korbonits, M
AF O'Toole, Samuel M.
   Denes, Judit
   Robledo, Mercedes
   Stratakis, Constantine A.
   Korbonits, Marta
TI The association of pituitary adenomas and phaeochromocytomas or
   paragangliomas
SO ENDOCRINE-RELATED CANCER
LA English
DT Review
DE pituitary; phaeochromocytoma; paraganglioma; SDH; pathogenesis
ID MULTIPLE ENDOCRINE NEOPLASIA; HIPPEL-LINDAU-DISEASE;
   RECEPTOR-INTERACTING PROTEIN; PAPILLARY THYROID-CARCINOMA;
   RET-GENE-EXPRESSION; GERM-LINE MUTATIONS; ISLET-CELL TUMOR;
   SUCCINATE-DEHYDROGENASE; BILATERAL PHEOCHROMOCYTOMA; ADRENAL INVOLVEMENT
AB The combination of pituitary adenomas (PA) and phaeochromocytomas (phaeo) or paragangliomas (PGL) is a rare event. Although these endocrine tumours may occur together by coincidence, there is mounting evidence that, in at least some cases, classical phaeo/PGL-predisposing genes may also play a role in pituitary tumorigenesis. A new condition that we termed '3Pas' for the association of PA with phaeo and/or PGL was recently described in patients with succinate dehydrogenase mutations and PAs. It should also be noted that the classical tumour suppressor gene, MEN1 that is the archetype of the PA-predisposing genes, is also rarely associated with phaeos in both mice and humans with MEN1 defects. In this report, we review the data leading to the discovery of 3PAs, other associations linking PAs with phaeos and/or PGLs, and the corresponding clinical and molecular genetics.
C1 [O'Toole, Samuel M.; Denes, Judit; Korbonits, Marta] Queen Mary Univ London, Barts & London Sch Med, Dept Endocrinol, London EC1M 6BQ, England.
   [Robledo, Mercedes] Spanish Natl Canc Ctr, Hereditary Endocrine Canc Grp, Madrid, Spain.
   [Robledo, Mercedes] ISCIII Ctr Biomed Res Rare Dis CIBERER, Madrid, Spain.
   [Stratakis, Constantine A.] Eunice Kennedy Shriver Inst Child Hlth & Human De, Sect Endocrinol & Genet, NIH, Bethesda, MD USA.
RP Korbonits, M (reprint author), Queen Mary Univ London, Barts & London Sch Med, Dept Endocrinol, London EC1M 6BQ, England.
EM m.korbonits@qmul.ac.uk
RI Robledo, Mercedes/O-2230-2013; 
OI Robledo, Mercedes/0000-0001-6256-5902; Korbonits,
   Marta/0000-0002-4101-9432
NR 132
TC 5
Z9 6
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1351-0088
EI 1479-6821
J9 ENDOCR-RELAT CANCER
JI Endocr.-Relat. Cancer
PD AUG
PY 2015
VL 22
IS 4
BP T105
EP T122
DI 10.1530/ERC-15-0241
PG 18
WC Oncology; Endocrinology & Metabolism
SC Oncology; Endocrinology & Metabolism
GA DJ0LX
UT WOS:000373896400004
PM 26113600
ER

PT J
AU Agalliu, I
   Chen, ZG
   Wang, T
   Ludvigsen, R
   Teras, L
   Kreimer, AR
   Hayes, RB
   Gapstur, S
   Burk, RD
AF Agalliu, Ilir
   Chen, Zigui
   Wang, Tao
   Ludvigsen, Rebecca
   Teras, Lauren
   Kreimer, Aimee R.
   Hayes, Richard B.
   Gapstur, Susan
   Burk, Robert D.
TI Oral HPV DNA detection and subsequent risk of head and neck cancers in
   two prospective cohorts
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Agalliu, Ilir; Chen, Zigui; Wang, Tao; Burk, Robert D.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Ludvigsen, Rebecca; Teras, Lauren; Gapstur, Susan] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Kreimer, Aimee R.] NCI, NIH, Bethesda, MD 20892 USA.
   [Hayes, Richard B.] NYU, New York, NY USA.
RI Chen, Zigui/E-8490-2017
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-181
DI 10.1158/1538-7445.AM2015-LB-181
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100281
ER

PT J
AU Ali-Rahmani, FG
   Fitzgerald, D
   Martin, S
   Patel, P
   Thomas, C
   Pastan, I
AF Ali-Rahmani, Fatima G.
   Fitzgerald, David
   Martin, Scott
   Patel, Paresma
   Thomas, Craig
   Pastan, Ira
TI Inhibition of collagen receptor discoidin domain receptor-1 (DDR1)
   tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin for
   cancer therapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ali-Rahmani, Fatima G.; Fitzgerald, David; Pastan, Ira] NCI, NIH, Bethesda, MD 20892 USA.
   [Martin, Scott; Patel, Paresma; Thomas, Craig] NIH, Natl Ctr Adv Translat Sci, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5357
DI 10.1158/1538-7445.AM2015-5357
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106018
ER

PT J
AU Amzallag, A
   Yuan, TL
   Bagni, R
   Yi, M
   Stephens, R
   Ramawamy, S
   McCormick, F
   Benes, CH
AF Amzallag, Arnaud
   Yuan, Tina L.
   Bagni, Rachel
   Yi, Ming
   Stephens, Robert
   Ramawamy, Sridhar
   McCormick, Frank
   Benes, Cyril H.
TI Querying the RAS genomic network with siRNAs and and flow cytometry:
   Automatic, multidimensional phenotyping of 135 cancer cell lines by
   Gaussian mixture fitting and expectation maximization
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Amzallag, Arnaud; Ramawamy, Sridhar; Benes, Cyril H.] Massachusetts Gen Hosp, Charlestown, MA USA.
   [Yuan, Tina L.; McCormick, Frank] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Bagni, Rachel; Yi, Ming; Stephens, Robert] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-247
DI 10.1158/1538-7445.AM2015-LB-247
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100341
ER

PT J
AU Anreddy, N
   Patel, A
   Zhang, YK
   Wang, YJ
   Shukla, S
   Kathawala, RJ
   Kumar, P
   Gupta, P
   Ambudkar, SV
   Wurpel, JND
   Chen, ZS
AF Anreddy, Nagaraju
   Patel, Atish
   Zhang, Yun-Kai
   Wang, Yi-Jun
   Shukla, Suneet
   Kathawala, Rishil J.
   Kumar, Priyank
   Gupta, Pranav
   Ambudkar, Suresh V.
   Wurpel, John N. D.
   Chen, Zhe-Sheng
TI A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates
   ABCG2-mediated MDR in vitro and in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Anreddy, Nagaraju; Patel, Atish; Zhang, Yun-Kai; Wang, Yi-Jun; Kathawala, Rishil J.; Kumar, Priyank; Gupta, Pranav; Wurpel, John N. D.; Chen, Zhe-Sheng] St Johns Univ, Queens, NY USA.
   [Shukla, Suneet; Ambudkar, Suresh V.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4432
DI 10.1158/1538-7445.AM2015-4432
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104063
ER

PT J
AU Ashktorab, H
   Nickerson, M
   Varma, S
   Mokarram, P
   Naghibalhossaini, F
   Moore, L
   Boland, J
   Bass, S
   Yeager, M
   Haung, WY
   Brim, H
AF Ashktorab, Hassan
   Nickerson, Michael
   Varma, Sudhir
   Mokarram, Pooneh
   Naghibalhossaini, Fakhraddin
   Moore, Lee
   Boland, Joseph
   Bass, Sara
   Yeager, Meredith
   Haung, Wen-Yi
   Brim, Hassan
TI Targeted cancer gene sequencing identifies potential causative novel
   candidate mutations among Caucasian colon carcinogenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ashktorab, Hassan; Brim, Hassan] Howard Univ, Washington, DC 20059 USA.
   [Nickerson, Michael; Moore, Lee] NCI, Frederick, MD 21701 USA.
   [Varma, Sudhir] Hithru, Iural, MD USA.
   [Mokarram, Pooneh; Naghibalhossaini, Fakhraddin] Shiraz Univ, Shiraz, Iran.
   [Boland, Joseph; Bass, Sara; Yeager, Meredith; Haung, Wen-Yi] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3930
DI 10.1158/1538-7445.AM2015-3930
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103027
ER

PT J
AU Banday, AR
   Paquin, A
   Middlebrooks, C
   Kiss, E
   Prokunina-Olsson, L
AF Banday, A. Rouf
   Paquin, Ashley
   Middlebrooks, Candace
   Kiss, Eniko
   Prokunina-Olsson, Ludmila
TI An alternatively spliced isoform of TMEM129 shows association with
   bladder cancer GWAS marker rs798766
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Banday, A. Rouf; Paquin, Ashley; Middlebrooks, Candace; Kiss, Eniko; Prokunina-Olsson, Ludmila] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4617
DI 10.1158/1538-7445.AM2015-4617
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104245
ER

PT J
AU Barry, KH
   Moore, LE
   Sampson, J
   Koutros, S
   Yan, LY
   Meyer, A
   Reddy, M
   Cook, MB
   Fraumeni, JF
   Yeager, M
   Amundadottir, L
   Berndt, SI
AF Barry, Kathryn Hughes
   Moore, Lee E.
   Sampson, Joshua
   Koutros, Stella
   Yan, Liying
   Meyer, Ann
   Reddy, Mahitha
   Cook, Michael B.
   Fraumeni, Joseph F.
   Yeager, Meredith
   Amundadottir, Laufey
   Berndt, Sonja I.
TI DNA methylation at chromosome 8q24 in peripheral blood and prostate
   cancer risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Barry, Kathryn Hughes; Moore, Lee E.; Sampson, Joshua; Koutros, Stella; Cook, Michael B.; Fraumeni, Joseph F.; Yeager, Meredith; Amundadottir, Laufey; Berndt, Sonja I.] NCI, DCEG, Bethesda, MD 20892 USA.
   [Yan, Liying; Meyer, Ann; Reddy, Mahitha] EpigenDx Inc, Hopkinton, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4604
DI 10.1158/1538-7445.AM2015-4604
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104232
ER

PT J
AU Beachler, DC
   Kreimer, AR
   Schiffman, M
   Herrero, R
   Wacholder, S
   Rodriguez, AC
   Lowy, DR
   Porras, C
   Schiller, JT
   Jimenez, S
   Struijk, L
   Schussler, J
   Hildesheim, A
   Gonzalez, P
AF Beachler, Daniel C.
   Kreimer, Aimee R.
   Schiffman, Mark
   Herrero, Rolando
   Wacholder, Sholom
   Rodriguez, Ana Cecilia
   Lowy, Douglas R.
   Porras, Carolina
   Schiller, John T.
   Jimenez, Silvia
   Struijk, Linda
   Schussler, John
   Hildesheim, Allan
   Gonzalez, Paula
CA Costa Rica Vaccine Trial Grp
TI Efficacy of the HPV16/18 vaccine against cervical, anal, and oral HPV
   infection among women with and without previous HPV16/18 exposure
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Beachler, Daniel C.; Kreimer, Aimee R.; Schiffman, Mark; Wacholder, Sholom; Lowy, Douglas R.; Schiller, John T.; Hildesheim, Allan] NCI, Bethesda, MD 20892 USA.
   [Herrero, Rolando] Int Agcy Res Canc, Lyon, France.
   [Rodriguez, Ana Cecilia; Porras, Carolina; Jimenez, Silvia; Gonzalez, Paula] Fdn INCINSA, Guanacaste, Costa Rica.
   [Struijk, Linda] DDL Diagnost Lab, Rijswijk, Netherlands.
   [Schussler, John] Informat Management Serv Inc, Calverton, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4680
DI 10.1158/1538-7445.AM2015-4680
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104308
ER

PT J
AU Biike, S
   Meltzer, P
AF Biike, Sven
   Meltzer, Paul
TI A single catastrophic genomic event is required for the development of
   osteosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Biike, Sven; Meltzer, Paul] NCI, Bethesda, MD 20892 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-192
DI 10.1158/1538-7445.AM2015-LB-192
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100291
ER

PT J
AU Biswas, K
   Chang, S
   Philip, S
   Sharan, SK
AF Biswas, Kajal
   Chang, Suhwan
   Philip, Subha
   Sharan, Shyam K.
TI BRE: a genetic interactor of BRCA2
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Biswas, Kajal; Chang, Suhwan; Philip, Subha; Sharan, Shyam K.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3952
DI 10.1158/1538-7445.AM2015-3952
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103048
ER

PT J
AU Bodelon, C
   Untereiner, M
   Vinokurova, S
   Machiela, MJ
   Wentzensen, N
AF Bodelon, Clara
   Untereiner, Micahel
   Vinokurova, Svetlana
   Machiela, Mitchell J.
   Wentzensen, Nicolas
TI Characterization of HPV integration sites in the human genome
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bodelon, Clara; Untereiner, Micahel; Machiela, Mitchell J.; Wentzensen, Nicolas] NCI, DCEG, Rockville, MD USA.
   [Vinokurova, Svetlana] Univ Hildelberg, Hilderberg, Germany.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5580
DI 10.1158/1538-7445.AM2015-5580
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106238
ER

PT J
AU Brafman, A
   Gudla, P
   Nandy, K
   Columbus, J
   Chen, D
   Worthy, K
   Lockett, S
   Turbyville, T
AF Brafman, Alla
   Gudla, Prabhakar
   Nandy, Kaustav
   Columbus, John
   Chen, De
   Worthy, Karen
   Lockett, Stephen
   Turbyville, Thomas
TI Targeting KRAS4b plasma membrane localization in cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Brafman, Alla; Gudla, Prabhakar; Nandy, Kaustav; Columbus, John; Chen, De; Worthy, Karen; Lockett, Stephen; Turbyville, Thomas] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4542
DI 10.1158/1538-7445.AM2015-4542
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104169
ER

PT J
AU Brown, AM
   Sankineni, S
   Bernardo, M
   Daar, D
   Weaver, J
   McKinney, Y
   Couvillon, A
   Gulley, JL
   Wood, BJ
   Pinto, PA
   Dahut, WL
   Madan, RA
   Choyke, PL
   Turkbey, B
AF Brown, Anna M.
   Sankineni, Sandeep
   Bernardo, Marcelino
   Daar, Dagane
   Weaver, Juanita
   McKinney, Yolanda
   Couvillon, Anna
   Gulley, James L.
   Wood, Bradford J.
   Pinto, Peter A.
   Dahut, William L.
   Madan, Ravi Amrit
   Choyke, Peter L.
   Turkbey, Baris
TI Ferumoxytol enhanced MRI for lymph node staging in genitourinary cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Brown, Anna M.; Sankineni, Sandeep; Bernardo, Marcelino; Daar, Dagane; Weaver, Juanita; McKinney, Yolanda; Choyke, Peter L.; Turkbey, Baris] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA.
   [Couvillon, Anna] NCI, Genitourinary Malignancies Branch, NIH, Bethesda, MD 20892 USA.
   [Gulley, James L.; Dahut, William L.; Madan, Ravi Amrit] NCI, NIH, Bethesda, MD 20892 USA.
   [Wood, Bradford J.] NCI, Ctr Intervent Oncol, NIH, Bethesda, MD 20892 USA.
   [Pinto, Peter A.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016
OI Gulley, James/0000-0002-6569-2912
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA CT222
DI 10.1158/1538-7445.AM2015-CT222
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100057
ER

PT J
AU Brown, KM
   Fang, J
   Jia, JP
   Wang, ZM
   Makowski, M
   Zhang, TW
   Hoskins, J
   Choi, J
   Han, YH
   Zhang, MF
   Xu, M
   Kanetsky, P
   Thorkell, A
   Petersen, GM
   Nathanson, KL
   Amos, CI
   Landi, MT
   Chanock, SJ
   Vermeulen, M
   Amundadottir, LT
AF Brown, Kevin M.
   Fang, Jun
   Jia, Jinping
   Wang, Zhaoming
   Makowski, Matthew
   Zhang, Tongwu
   Hoskins, Jason
   Choi, Jiyeon
   Han, Younghun
   Zhang, Mingfeng
   Xu, Mai
   Kanetsky, Peter
   Thorkell, Andresson
   Petersen, Gloria M.
   Nathanson, Katherine L.
   Amos, Christopher I.
   Landi, Maria T.
   Chanock, Stephen J.
   Vermeulen, Michiel
   Amundadottir, Laufey T.
TI Functional characterization of a multicancer risk locus on chr5p15.33
   reveals regulation of TERT by ZNF148
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Brown, Kevin M.; Fang, Jun; Jia, Jinping; Wang, Zhaoming; Zhang, Tongwu; Hoskins, Jason; Choi, Jiyeon; Zhang, Mingfeng; Xu, Mai; Landi, Maria T.; Chanock, Stephen J.; Amundadottir, Laufey T.] NCI, Bethesda, MD 20892 USA.
   [Makowski, Matthew; Vermeulen, Michiel] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Han, Younghun; Amos, Christopher I.] Dartmouth Coll, Hanover, NH 03755 USA.
   [Kanetsky, Peter] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
   [Thorkell, Andresson] Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Petersen, Gloria M.] Mayo Clin, Rochester, MD USA.
   [Nathanson, Katherine L.] Univ Penn, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4610
DI 10.1158/1538-7445.AM2015-4610
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104238
ER

PT J
AU Bunch, K
   Goldlust, I
   Thomas, C
   Hernandez, L
   Guha, R
   Annunziata, C
AF Bunch, Kristen
   Goldlust, Ian
   Thomas, Craig
   Hernandez, Lidia
   Guha, Rajarshi
   Annunziata, Christina
TI High-throughput drug matrix screen with SMAC (second
   mitochondria-derived activator of caspases)-mimetic birinapant in
   high-grade serous ovarian cancer cell lines identifies synergism
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bunch, Kristen] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
   [Goldlust, Ian; Thomas, Craig; Guha, Rajarshi] NIH, Natl Ctr Adv Translat Sci, Bethesda, MD 20892 USA.
   [Hernandez, Lidia; Annunziata, Christina] NCI, Womens Malignancies Branch, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-254
DI 10.1158/1538-7445.AM2015-LB-254
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100348
ER

PT J
AU Camargo, MC
   Bowlby, R
   Chu, A
   Pedamallu, CS
   Thorsson, V
   Elmore, S
   Mungall, A
   Bass, A
   Gulley, ML
   Rabkin, CS
AF Camargo, M. Constanza
   Bowlby, Reanne
   Chu, Andy
   Pedamallu, Chandra S.
   Thorsson, Vesteinn
   Elmore, Sandra
   Mungall, Andrew
   Bass, Adam
   Gulley, Margaret L.
   Rabkin, Charles S.
TI Validation and calibration of next-generation sequencing to identify
   Epstein-Barr Virus-positive gastric cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Camargo, M. Constanza; Rabkin, Charles S.] NCI, Bethesda, MD 20892 USA.
   [Bowlby, Reanne; Chu, Andy; Mungall, Andrew] BC Canc Agcy, Vancouver, BC, Canada.
   [Pedamallu, Chandra S.] Broad Inst, Cambridge, MA USA.
   [Thorsson, Vesteinn] Inst Syst Biol, Seattle, WA USA.
   [Elmore, Sandra; Gulley, Margaret L.] Univ N Carolina, Chapel Hill, NC USA.
   [Bass, Adam] Dana Farber Canc Inst, Boston, MA 02115 USA.
RI Camargo, M. Constanza/R-9891-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4621
DI 10.1158/1538-7445.AM2015-4621
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104249
ER

PT J
AU Carlson, S
   Eytan, D
   Snow, G
   Schiltz, S
   Mohan, S
   Saleh, A
   Cornelius, S
   Coupar, J
   Van Waes, C
   Chen, Z
AF Carlson, Sophie
   Eytan, Danielle
   Snow, Grace
   Schiltz, Stephen
   Mohan, Suresh
   Saleh, Anthony
   Cornelius, Shaleeka
   Coupar, Jamie
   Van Waes, Carter
   Chen, Zhong
TI Novel SMAC-mimetic birinapant demonstrates antitumor activity in human
   head and neck cancer models exhibiting alterations in cell death
   pathways
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Carlson, Sophie; Saleh, Anthony; Cornelius, Shaleeka; Coupar, Jamie; Van Waes, Carter; Chen, Zhong] NIH, Bethesda, MD 20892 USA.
   [Eytan, Danielle] Cleveland Clin, Cleveland, OH 44106 USA.
   [Snow, Grace; Schiltz, Stephen] Univ Maryland, Bethesda, MD USA.
   [Mohan, Suresh] Brown Univ, Providence, RI 02912 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3622
DI 10.1158/1538-7445.AM2015-3622
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102162
ER

PT J
AU Cecchi, F
   Liao, WL
   Thyparambil, S
   Darfler, M
   Krizman, D
   Hembrough, T
   Burrows, J
   Bottaro, D
   Catenacci, DVT
AF Cecchi, Fabiola
   Liao, Wei-Li
   Thyparambil, Sheeno
   Darfler, Marlene
   Krizman, David
   Hembrough, Todd
   Burrows, Jon
   Bottaro, Don
   Catenacci, Daniel V. T.
TI A novel clinical tool that provides quantitative and accurate
   measurement of Met protein
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Cecchi, Fabiola; Liao, Wei-Li; Thyparambil, Sheeno; Darfler, Marlene; Krizman, David; Hembrough, Todd; Burrows, Jon] Oncoplex Diagnost, Rockville, MD USA.
   [Bottaro, Don] NCI, Bethesda, MD 20892 USA.
   [Catenacci, Daniel V. T.] Univ Chicago, Chicago, IL 60637 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3397
DI 10.1158/1538-7445.AM2015-3397
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101425
ER

PT J
AU Chaisaingmongkol, J
   Budhu, A
   Dang, H
   Rabibhadana, S
   Pupacdi, B
   Forgues, M
   Bhudhisawasdi, V
   Lertprasertsuke, N
   Chotirosniramit, A
   Pairojkul, C
   Auewarakul, CU
   Sricharunrat, T
   Phornphutkul, K
   Sangrajrang, S
   Cam, M
   He, P
   Hewitt, SM
   Wu, XL
   Thorgeirsson, SS
   Meltzer, PS
   Loffredo, CA
   Wiltrout, RH
   Harris, CC
   Mahidol, C
   Ruchirawat, M
   Wang, XW
AF Chaisaingmongkol, Jittiporn
   Budhu, Anuradha
   Dang, Hien
   Rabibhadana, Siritida
   Pupacdi, Benjarath
   Forgues, Marshonna
   Bhudhisawasdi, Vajarabhongsa
   Lertprasertsuke, Nirush
   Chotirosniramit, Anon
   Pairojkul, Chawalit
   Auewarakul, Chirayu U.
   Sricharunrat, Thaniya
   Phornphutkul, Kannika
   Sangrajrang, Suleeporn
   Cam, Maggie
   He, Ping
   Hewitt, Stephen M.
   Wu, Xiaolin
   Thorgeirsson, Snorri S.
   Meltzer, Paul S.
   Loffredo, Christopher A.
   Wiltrout, Robert H.
   Harris, Curtis C.
   Mahidol, Chulabhorn
   Ruchirawat, Mathuros
   Wang, Xin W.
TI The Thailand initiative in genomics and expression research for liver
   cancer (TIGER-LC): Defining novel subtypes of hepatocellular carcinoma
   and cholangiocarcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chaisaingmongkol, Jittiporn; Budhu, Anuradha; Dang, Hien; Forgues, Marshonna; Cam, Maggie; Hewitt, Stephen M.; Wu, Xiaolin; Thorgeirsson, Snorri S.; Meltzer, Paul S.; Wiltrout, Robert H.; Harris, Curtis C.; Wang, Xin W.] NCI, Bethesda, MD 20892 USA.
   [Rabibhadana, Siritida; Pupacdi, Benjarath; Mahidol, Chulabhorn; Ruchirawat, Mathuros] Chulabhorn Res Inst, Bangkok, Thailand.
   [Bhudhisawasdi, Vajarabhongsa; Pairojkul, Chawalit] Khon Kaen Univ, Khon Kaen, Thailand.
   [Lertprasertsuke, Nirush; Chotirosniramit, Anon] Chiang Mai Univ, Chiang Mai 50000, Thailand.
   [Auewarakul, Chirayu U.; Sricharunrat, Thaniya] Chulabhorn Hosp, Bangkok, Thailand.
   [Phornphutkul, Kannika] Rajavej Hosp, Chiang Mai, Thailand.
   [Sangrajrang, Suleeporn] Natl Canc Inst, Bangkok, Thailand.
   [He, Ping] US FDA, Bethesda, MD 20014 USA.
   [Loffredo, Christopher A.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-173
DI 10.1158/1538-7445.AM2015-LB-173
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100273
ER

PT J
AU Chang, WI
   Brohl, AS
   Patidar, R
   Shern, JF
   Wei, JS
   Song, YK
   Liao, HL
   Lin, J
   Sindiri, S
   Chen, L
   Gryder, B
   Yohe, ME
   Zhang, SL
   Merchant, MS
   Widemann, BC
   Khan, J
AF Chang, Wen-I
   Brohl, Andrew S.
   Patidar, Rajesh
   Shern, Jack F.
   Wei, Jun S.
   Song, Young K.
   Liao, Hongling
   Lin, Jimmy
   Sindiri, Sivasish
   Chen, Li
   Gryder, Berkley
   Yohe, Marielle E.
   Zhang, Shile
   Merchant, Melinda S.
   Widemann, Brigitte C.
   Khan, Javed
TI Clinical exome and transcriptome sequencing for identification of
   actionable cancer targets: A pilot study for children and young adults
   with relapsed or refractory solid tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chang, Wen-I; Yohe, Marielle E.] Johns Hopkins NCI, Baltimore, MD USA.
   [Brohl, Andrew S.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Patidar, Rajesh; Shern, Jack F.; Wei, Jun S.; Song, Young K.; Liao, Hongling; Lin, Jimmy; Sindiri, Sivasish; Chen, Li; Gryder, Berkley; Zhang, Shile; Merchant, Melinda S.; Widemann, Brigitte C.; Khan, Javed] NCI, Bethesda, MD 20892 USA.
RI Khan, Javed/P-9157-2014
OI Khan, Javed/0000-0002-5858-0488
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3882
DI 10.1158/1538-7445.AM2015-3882
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102406
ER

PT J
AU Chelluri, R
   Agarwal, PK
   Neckers, LM
   Smith, AK
AF Chelluri, Raju
   Agarwal, Piyush K.
   Neckers, Leonard M.
   Smith, Armine K.
TI Synergistic effect of targeted combination therapy in bladder cancer
   model using HSP90 inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chelluri, Raju; Agarwal, Piyush K.; Neckers, Leonard M.] NCI, Bethesda, MD 20892 USA.
   [Smith, Armine K.] Johns Hopkins Univ, Brady Urol Inst, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3796
DI 10.1158/1538-7445.AM2015-3796
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102325
ER

PT J
AU Chen, J
   Chen, JS
   Zhang, JP
   Phan, L
   Munoz, NM
   Katz, LH
   Gi, YJ
   Menon, VK
   Shin, JH
   Jeong, YS
   Jogunoori, W
   Farci, P
   Shetty, K
   Su, XP
   Pandita, TK
   White, J
   Mishra, B
   Zamboni, F
   Wu, XF
   Rashid, A
   Li, SL
   Javle, M
   Hung, MC
   Herlong, F
   Davila, M
   Stroehlein, J
   Shaw, KR
   Wang, XM
   Morris, JS
   Akbani, R
   Mishra, L
AF Chen, Jian
   Chen, Jiun-Sheng
   Zhang, Jianping
   Phan, Liem
   Munoz, Nina M.
   Katz, Lior H.
   Gi, YoungJin
   Menon, Vipin Kumar
   Shin, Ji-Hyun
   Jeong, Yun Seong
   Jogunoori, Wilma
   Farci, Patrizia
   Shetty, Kirti
   Su, Xiaoping
   Pandita, Tej K.
   White, Jon
   Mishra, Bibhuti
   Zamboni, Fausto
   Wu, Xifeng
   Rashid, Asif
   Li, Shulin
   Javle, Milind
   Hung, Mien-Chie
   Herlong, Franklin
   Davila, Marta
   Stroehlein, John
   Shaw, Kenna R.
   Wang, Xuemei
   Morris, Jeffrey S.
   Akbani, Rehan
   Mishra, Lopa
TI Genomic landscape of human cancer reveals dysregulated TGF-beta
   signaling with prognostic significance
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chen, Jian; Chen, Jiun-Sheng; Zhang, Jianping; Phan, Liem; Munoz, Nina M.; Katz, Lior H.; Gi, YoungJin; Menon, Vipin Kumar; Shin, Ji-Hyun; Jeong, Yun Seong; Su, Xiaoping; Wu, Xifeng; Rashid, Asif; Li, Shulin; Javle, Milind; Hung, Mien-Chie; Herlong, Franklin; Davila, Marta; Stroehlein, John; Shaw, Kenna R.; Wang, Xuemei; Morris, Jeffrey S.; Akbani, Rehan; Mishra, Lopa] UT MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Jogunoori, Wilma; White, Jon; Mishra, Bibhuti] Vet Affairs Med Ctr, Inst Clin Res, Washington, DC 20422 USA.
   [Farci, Patrizia] NIAID, NIH, Bethesda, MD 20892 USA.
   [Shetty, Kirti] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA.
   [Pandita, Tej K.] Houston Methodist Res Inst, Houston, TX USA.
   [Zamboni, Fausto] Brotzu Hosp, Liver & Pancreas Transplantat, Cagliari, Italy.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3900
DI 10.1158/1538-7445.AM2015-3900
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102424
ER

PT J
AU Cheng, H
   Yang, XP
   Si, H
   Saleh, A
   Coupar, J
   Ferris, RL
   Yarbrough, WG
   Prince, ME
   Carey, TE
   Van Waes, C
   Chen, Z
AF Cheng, Hui
   Yang, Xinping
   Si, Han
   Saleh, Anthony
   Coupar, Jamie
   Ferris, Robert L.
   Yarbrough, Wendell G.
   Prince, Mark E.
   Carey, Thomas E.
   Van Waes, Carter
   Chen, Zhong
TI High throughput whole exome DNA and transcriptome RNA sequencing to
   identify genetic drivers and alterations in HPV-negative and
   HPV-positive HNSCC cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Cheng, Hui; Yang, Xinping; Si, Han; Saleh, Anthony; Coupar, Jamie; Van Waes, Carter; Chen, Zhong] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD USA.
   [Ferris, Robert L.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Yarbrough, Wendell G.] Yale Univ, Sch Med, Yale Canc Ctr, Smilow Canc Hosp, New Haven, CT USA.
   [Prince, Mark E.; Carey, Thomas E.] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4804
DI 10.1158/1538-7445.AM2015-4804
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104429
ER

PT J
AU Chiou, VL
   Annunziata, C
   Lipkowitz, S
   Minasian, L
   Gordon, N
   Yu, MS
   Steinberg, S
   Houston, N
   Kohn, E
   Lee, JM
AF Chiou, Victoria L.
   Annunziata, Christina
   Lipkowitz, Stanley
   Minasian, Lori
   Gordon, Nicolas
   Yu, Minshu
   Steinberg, Seth
   Houston, Nicole
   Kohn, Elise
   Lee, Jung-min
TI Pharmacokinetic/pharmacodynamic study of sequence specificity of the
   PARP inhibitor, olaparib and carboplatin in recurrent women's cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chiou, Victoria L.; Annunziata, Christina; Lipkowitz, Stanley; Minasian, Lori; Gordon, Nicolas; Yu, Minshu; Houston, Nicole; Kohn, Elise; Lee, Jung-min] NCI, Womens Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Steinberg, Seth] NCI, Biostat & Data Management Sect, Off Clin Director, Ctr Canc Res, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA CT326
DI 10.1158/1538-7445.AM2015-CT326
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100098
ER

PT J
AU Chung, YJ
   Kim, S
   Aplan, P
AF Chung, Yang Jo
   Kim, Suntae
   Aplan, Peter
TI De-differentiation of CD45+hematopoietic cells to CD45-stromal cells in
   vitro
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chung, Yang Jo; Kim, Suntae; Aplan, Peter] NCI, NIH, Bethesda, MD 20892 USA.
RI Aplan, Peter/K-9064-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5086
DI 10.1158/1538-7445.AM2015-5086
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105264
ER

PT J
AU Crawford, C
   Caga-Anan, C
   Kaufman, D
   Lee, A
   Mcewen, J
   Schully, S
   Hutter, C
   Hindorff, L
AF Crawford, Catherine
   Caga-Anan, Charlisse
   Kaufman, Dave
   Lee, Alexander
   Mcewen, Jean
   Schully, Sheri
   Hutter, Carolyn
   Hindorff, Lucia
TI Clinical sequencing in the National Institute of Health's Clinical
   Sequencing Exploratory Research (CSER) Program
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Crawford, Catherine; Kaufman, Dave; Lee, Alexander; Mcewen, Jean; Hutter, Carolyn; Hindorff, Lucia] NHGRI, Bethesda, MD 20892 USA.
   [Caga-Anan, Charlisse; Schully, Sheri] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4888
DI 10.1158/1538-7445.AM2015-4888
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105073
ER

PT J
AU Crystal, JS
   Prickett, T
   Lu, YC
   Gartner, JJ
   Parkhurst, M
   Gros, A
   Li, YF
   El-Gamil, M
   Rosenberg, SA
   Robbins, PF
AF Crystal, Jessica S.
   Prickett, Todd
   Lu, Yong-Chen
   Gartner, Jared J.
   Parkhurst, Maria
   Gros, Alena
   Li, Yong F.
   El-Gamil, Mona
   Rosenberg, Steven A.
   Robbins, Paul F.
TI Diversity of tumor infiltrating lymphocyte recognition of diverse
   mutated antigens in cutaneous melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Crystal, Jessica S.; Prickett, Todd; Lu, Yong-Chen; Gartner, Jared J.; Parkhurst, Maria; Gros, Alena; Li, Yong F.; El-Gamil, Mona; Rosenberg, Steven A.; Robbins, Paul F.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-221
DI 10.1158/1538-7445.AM2015-LB-221
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100317
ER

PT J
AU Czikora, A
   Lundberg, DJ
   Lewin, NE
   Kedei, N
   Blumberg, PM
AF Czikora, Agnes
   Lundberg, Daniel J.
   Lewin, Nancy E.
   Kedei, Noemi
   Blumberg, Peter M.
TI Structural basis for the failure of the C1 domain of RasGRP2 to bind
   phorbol ester
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Czikora, Agnes; Lewin, Nancy E.; Kedei, Noemi; Blumberg, Peter M.] NCI, LCBG, Bethesda, MD 20892 USA.
   [Lundberg, Daniel J.] Gallaudet Univ, Washington, DC 20002 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3928
DI 10.1158/1538-7445.AM2015-3928
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103025
ER

PT J
AU Das, R
   Cheng, TF
   Coupar, J
   Saleh, A
   Yang, XP
   Zhang, JL
   Cornelius, S
   Van Waes, C
   Chen, Z
AF Das, Rita
   Cheng, Tsu-Fang
   Coupar, Jamie
   Saleh, Anthony
   Yang, Xingping
   Zhang, Jialing
   Cornelius, Shaleeka
   Van Waes, Carter
   Chen, Zhong
TI LT beta receptor and NIK signaling activates the alternative NF-kB
   pathway in head and neck squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Das, Rita; Cheng, Tsu-Fang; Coupar, Jamie; Saleh, Anthony; Yang, Xingping; Zhang, Jialing; Cornelius, Shaleeka; Van Waes, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5253
DI 10.1158/1538-7445.AM2015-5253
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105422
ER

PT J
AU Ding, X
   Sharan, SK
AF Ding, Xia
   Sharan, Shyam K.
TI GIPC high expression rescues BRCA2 deficiency and promotes tumorigenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ding, Xia; Sharan, Shyam K.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3019
DI 10.1158/1538-7445.AM2015-3019
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101069
ER

PT J
AU Divi, RL
   Verma, M
   Dickherber, A
AF Divi, Rao L.
   Verma, Mukesh
   Dickherber, Anthony
TI Technologies for molecular epidemiology in cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Divi, Rao L.; Verma, Mukesh] NCI, DCCPS, Bethesda, MD 20892 USA.
   [Dickherber, Anthony] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5571
DI 10.1158/1538-7445.AM2015-5571
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106230
ER

PT J
AU Dobi, A
   Degon, M
   Farrell, J
   Baptiste, W
   Young, D
   Chen, YM
   Petrovics, G
   Cullen, J
   Kagan, J
   Srivastava, S
   Rosner, I
   McLeod, DG
   Srivastava, S
   Sesterhenn, I
AF Dobi, Albert
   Degon, Michael
   Farrell, James
   Baptiste, Wagner
   Young, Denise
   Chen, Yongmei
   Petrovics, Gyorgy
   Cullen, Jennifer
   Kagan, Jacob
   Srivastava, Sudir
   Rosner, Inger
   McLeod, David G.
   Srivastava, Shiv
   Sesterhenn, Isabel
TI ERG-based stratification of prostate cancer highlights ethnicity
   associated biological differences
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Dobi, Albert; Degon, Michael; Farrell, James; Baptiste, Wagner; Young, Denise; Chen, Yongmei; Petrovics, Gyorgy; Cullen, Jennifer; Rosner, Inger; McLeod, David G.; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA.
   [Kagan, Jacob; Srivastava, Sudir] NCI, Canc Prevent Div, Canc Biomarkers Res Grp, Bethesda, MD 20892 USA.
   [Sesterhenn, Isabel] Joint Pathol Ctr, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5277
DI 10.1158/1538-7445.AM2015-5277
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105444
ER

PT J
AU Doci, CL
   Mikelis, CM
   Lionakis, MS
   Molinolo, AA
   Gutkind, JS
AF Doci, Colleen L.
   Mikelis, Constantinos M.
   Lionakis, Michail S.
   Molinolo, Alfredo A.
   Gutkind, J. Silvio
TI Recurrent 3p21 deletion in head and neck squamous cell carcinoma
   identifies SEMA3F as an anti-lymphangiogenic metastasis suppressor gene
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Doci, Colleen L.; Mikelis, Constantinos M.; Lionakis, Michail S.; Molinolo, Alfredo A.; Gutkind, J. Silvio] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3249
DI 10.1158/1538-7445.AM2015-3249
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101278
ER

PT J
AU Dominguez, C
AF Dominguez, Charli
TI Short-term blockade of EGF signaling improves immune-mediated
   cytotoxicity of NSCLC cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Dominguez, Charli] NIH, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5016
DI 10.1158/1538-7445.AM2015-5016
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105196
ER

PT J
AU Eiseman, JL
   Holleran, J
   McCormick, DL
   Muzzio, M
   Covey, JM
   Khanna, C
   Mazcko, C
   Pommier, Y
   Paolini, M
   Leblanc, A
   Burton, JH
   Doroshow, JH
   Tomaszewski, JE
   Beumer, JH
AF Eiseman, Julie L.
   Holleran, Julianne
   McCormick, David L.
   Muzzio, Miguel
   Covey, Joseph M.
   Khanna, Chand
   Mazcko, Christina
   Pommier, Yves
   Paolini, Melissa
   Leblanc, Amy
   Burton, Jenna H.
   Doroshow, James H.
   Tomaszewski, Joseph E.
   Beumer, Jan H.
TI Plasma and tumor pharmacokinetics of IV LMP744, a novel
   indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Eiseman, Julie L.; Holleran, Julianne; Beumer, Jan H.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [McCormick, David L.; Muzzio, Miguel] ITT Res Inst, Chicago, IL USA.
   [Covey, Joseph M.; Khanna, Chand; Mazcko, Christina; Pommier, Yves; Paolini, Melissa; Leblanc, Amy; Doroshow, James H.; Tomaszewski, Joseph E.] NCI, Bethesda, MD 20892 USA.
   [Burton, Jenna H.] Univ Calif Davis, Sacramento, CA USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4517
DI 10.1158/1538-7445.AM2015-4517
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104144
ER

PT J
AU Ellis, NA
   Yang, WC
   Yagle, M
   Zhu, JM
   Huang, J
   Seidman, M
   Matunis, MJ
AF Ellis, Nathan A.
   Yang, Wei-Chih
   Yagle, Mary
   Zhu, Jianmei
   Huang, Jing
   Seidman, Michael
   Matunis, Michael J.
TI The SUMO-targeted ubiquitin ligase RNF4 regulates BLM helicase's
   function in dormant origin firing
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ellis, Nathan A.; Yagle, Mary] Univ Arizona, Tucson, AZ USA.
   [Yang, Wei-Chih; Zhu, Jianmei; Matunis, Michael J.] Johns Hopkins Univ, Baltimore, MD USA.
   [Huang, Jing; Seidman, Michael] NIA, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3036
DI 10.1158/1538-7445.AM2015-3036
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101085
ER

PT J
AU Emerling, BM
   Yang, ZW
   Loughran, R
   Yang, TJ
   Johnson, J
   Pragani, R
   Davis, M
   Shen, M
   Boxer, M
   Simeonov, A
   Cantley, LC
AF Emerling, Brooke M.
   Yang, Zhiwei
   Loughran, Ryan
   Yang, T. Jonathan
   Johnson, Jared
   Pragani, Rajan
   Davis, Mindy
   Shen, Min
   Boxer, Matthew
   Simeonov, Anton
   Cantley, Lewis C.
TI Targeting p53 mutant cancers through inhibition of the
   phosphatidylinositol-5-phosphate 4-kinases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Emerling, Brooke M.; Yang, Zhiwei; Loughran, Ryan; Johnson, Jared; Cantley, Lewis C.] Weill Cornell Med Coll, New York Presbyterian, New York, NY USA.
   [Yang, T. Jonathan] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Pragani, Rajan; Davis, Mindy; Shen, Min; Boxer, Matthew; Simeonov, Anton] NIH, Natl Ctr Adv Translat Sci, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4714
DI 10.1158/1538-7445.AM2015-4714
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104342
ER

PT J
AU Evans, J
   Giles, A
   Reid, C
   Kaplan, R
AF Evans, Justin
   Giles, Amber
   Reid, Caitlin
   Kaplan, Rosandra
TI CSF-1R inhibition blocks rhabdomyoscarcoma metastasis by polarizing
   macrophage differentiation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Evans, Justin; Giles, Amber; Reid, Caitlin; Kaplan, Rosandra] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4126
DI 10.1158/1538-7445.AM2015-4126
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103214
ER

PT J
AU Ferry-Galow, KV
   Lawrence, SM
   Navas, T
   Makhlouf, HR
   Butcher, DO
   Gouker, BA
   Yutzy, WH
   Ji, JP
   Kinders, R
   Parchment, RE
   Kummar, S
   Tomaszewski, JE
   Doroshow, JH
AF Ferry-Galow, Katherine V.
   Lawrence, Scott M.
   Navas, Tony
   Makhlouf, Hala R.
   Butcher, Donna O.
   Gouker, Brad A.
   Yutzy, William H.
   Ji, Jiuping
   Kinders, Robert
   Parchment, Ralph E.
   Kummar, Shivaani
   Tomaszewski, Joseph E.
   Doroshow, James H.
TI Establishing robust pharmacodynamic (PD) immunofluorescence assays of
   clinical biopsies at the National Cancer Institute: Optimized quality
   control procedures for the evaluation of DNA damage response and
   epithelial-mesenchymal transition (EMT) biomarkers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ferry-Galow, Katherine V.; Lawrence, Scott M.; Navas, Tony; Butcher, Donna O.; Gouker, Brad A.; Yutzy, William H.; Ji, Jiuping; Kinders, Robert; Parchment, Ralph E.] Leidos Biomed Res Inc, Frederick, MD USA.
   [Makhlouf, Hala R.] Div Canc Treatment & Diag, Canc Diag Program, Rockville, MD USA.
   [Kummar, Shivaani; Doroshow, James H.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5279
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105446
ER

PT J
AU Figueroa, JD
   Pfeiffer, R
   Palakal, M
   Degnim, AC
   Radisky, D
   Hartmann, LC
   Frost, M
   Mann, MLS
   Brinton, LA
   Papathomas, D
   Visscher, D
   Sherman, ME
AF Figueroa, Jonine D.
   Pfeiffer, Ruth
   Palakal, Maya
   Degnim, Amy C.
   Radisky, Derek
   Hartmann, Lynn C.
   Frost, Marlene
   Mann, Melody L. Stallings
   Brinton, Louise A.
   Papathomas, Daphne
   Visscher, Daniel
   Sherman, Mark E.
TI Standardized measures of lobular involution and subsequent breast cancer
   risk among women with benign breast disease
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Figueroa, Jonine D.; Pfeiffer, Ruth; Palakal, Maya; Brinton, Louise A.; Papathomas, Daphne] NCI DCEG, Bethesda, MD USA.
   [Degnim, Amy C.; Radisky, Derek; Hartmann, Lynn C.; Frost, Marlene; Mann, Melody L. Stallings; Visscher, Daniel] Mayo Clin, Ctr Canc, Rochester, MN USA.
   [Sherman, Mark E.] NCI DCP, Bethesda, MD USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4682
DI 10.1158/1538-7445.AM2015-4682
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104310
ER

PT J
AU Fujita, M
   Imadome, K
   Shoji, Y
   Cheng, R
   Kesarwala, AH
   Wink, DA
   Imai, T
AF Fujita, Mayumi
   Imadome, Kaori
   Shoji, Yoshimi
   Cheng, Robert
   Kesarwala, Aparna H.
   Wink, David A.
   Imai, Takashi
TI Role of nitric oxide in invasiveness of tumor cells irradiated with
   carbon-ion beams
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Fujita, Mayumi; Imadome, Kaori; Shoji, Yoshimi; Imai, Takashi] Natl Inst Radiol Sci, Chiba 260, Japan.
   [Cheng, Robert; Kesarwala, Aparna H.; Wink, David A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4140
DI 10.1158/1538-7445.AM2015-4140
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103228
ER

PT J
AU Gao, SJ
   Cultraro, C
   Blswas, R
   Carter, CA
   Maity, TK
   Thomas, A
   Rajan, A
   Meltzer, P
   Schrump, D
   Giaccone, G
   Khan, J
   Guha, U
AF Gao, Shaojian
   Cultraro, Constance
   Blswas, Romi
   Carter, Corey A.
   Maity, Tapan K.
   Thomas, Anish
   Rajan, Arun
   Meltzer, Paul
   Schrump, David
   Giaccone, Giuseppe
   Khan, Javed
   Guha, Udayan
TI Whole genome sequencing of sequentially acquired lung and lymph node
   metastatic sites from a never smoker lung adenocarcinoma patient
   revealed extensive genomic heterogeneity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Gao, Shaojian; Cultraro, Constance; Blswas, Romi; Maity, Tapan K.; Thomas, Anish; Rajan, Arun; Meltzer, Paul; Schrump, David; Giaccone, Giuseppe; Khan, Javed; Guha, Udayan] NCI, Bethesda, MD 20892 USA.
   [Carter, Corey A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4759
DI 10.1158/1538-7445.AM2015-4759
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104386
ER

PT J
AU Gavin, PG
   Song, N
   Johnson, NL
   Lipchik, C
   Kim, SR
   Finnigan, M
   Bandos, H
   Jeong, JH
   Costantino, JP
   Rastogi, P
   Romond, EH
   Fehrenbacher, L
   Mamounas, EP
   Swain, SM
   Wickerham, DL
   Geyer, CE
   Wolmark, N
   Paik, S
   Pogue-Geile, KL
AF Gavin, Patrick G.
   Song, Nan
   Johnson, Nicole L.
   Lipchik, Corey
   Kim, Seong-Rim
   Finnigan, Melanie
   Bandos, Hanna
   Jeong, Jong-Hyeon
   Costantino, Joseph P.
   Rastogi, Priya
   Romond, Edward H.
   Fehrenbacher, Louis
   Mamounas, Eleftherios P.
   Swain, Sandra M.
   Wickerham, D. Lawrence
   Geyer, Charles E., Jr.
   Wolmark, Norman
   Paik, Soonmyung
   Pogue-Geile, Katherine L.
TI Association of the FCGR2A and FCGR3A genotypes with trastuzumab benefit
   in NSABP B-31
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Gavin, Patrick G.; Song, Nan; Johnson, Nicole L.; Lipchik, Corey; Kim, Seong-Rim; Finnigan, Melanie; Bandos, Hanna; Jeong, Jong-Hyeon; Costantino, Joseph P.; Rastogi, Priya; Romond, Edward H.; Fehrenbacher, Louis; Mamounas, Eleftherios P.; Swain, Sandra M.; Wickerham, D. Lawrence; Geyer, Charles E., Jr.; Wolmark, Norman; Paik, Soonmyung; Pogue-Geile, Katherine L.] NSABP, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA CT129
DI 10.1158/1538-7445.AM2015-CT129
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100025
ER

PT J
AU Giles, AJ
   Murgai, M
   Vicioso, Y
   Hightfill, S
   Kasai, M
   Vandat, L
   Wexler, L
   Mackall, C
   Lyden, D
   Kaplan, R
AF Giles, Amber J.
   Murgai, Meera
   Vicioso, Yorleny
   Hightfill, Steven
   Kasai, Miki
   Vandat, Linda
   Wexler, Leonard
   Mackall, Crystal
   Lyden, David
   Kaplan, Rosandra
TI Hematopoietic stem cell niche activation and progenitor mobilization
   mediate cancer-associated immunosuppression and metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Giles, Amber J.; Murgai, Meera; Vicioso, Yorleny; Hightfill, Steven; Kasai, Miki; Mackall, Crystal; Kaplan, Rosandra] NIH, Bethesda, MD 20892 USA.
   [Vandat, Linda] Weill Cornell Breast Canc, New York, NY USA.
   [Wexler, Leonard] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Lyden, David] Weill Cornell Med Coll, New York, NY USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4725
DI 10.1158/1538-7445.AM2015-4725
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104353
ER

PT J
AU Goey, AKL
   Sissung, TM
   Peer, CJ
   Ehrlich, S
   Bryla, C
   Berman, AW
   Balasubramaniam, S
   Rajan, A
   Giaccone, G
   Bates, SE
   Figg, WD
AF Goey, Andrew K. L.
   Sissung, Tristan M.
   Peer, Cody J.
   Ehrlich, Sheryl
   Bryla, Christina
   Berman, Arlene W.
   Balasubramaniam, Sanjeeve
   Rajan, Arun
   Giaccone, Giuseppe
   Bates, Susan E.
   Figg, William D.
TI Effects of UGT1A1 genotype on pharmacokinetics and toxicities of
   belinostat administered by continuous infusion in two clinical trials
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Goey, Andrew K. L.; Sissung, Tristan M.; Peer, Cody J.; Ehrlich, Sheryl; Bryla, Christina; Berman, Arlene W.; Balasubramaniam, Sanjeeve; Rajan, Arun; Giaccone, Giuseppe; Bates, Susan E.; Figg, William D.] NCI, Bethesda, MD 20892 USA.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5480
DI 10.1158/1538-7445.AM2015-5480
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106138
ER

PT J
AU Greer, YE
   Gao, B
   Yang, YZ
   Lipkowitz, S
   Rubin, JS
AF Greer, Yoshimi E.
   Gao, Bo
   Yang, Yingzi
   Lipkowitz, Stanley
   Rubin, Jeff S.
TI Lack of CK1 delta increases DNA damage and genomic instability due to
   defects in DNA repair and mitotic checkpoints
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Greer, Yoshimi E.; Lipkowitz, Stanley; Rubin, Jeff S.] NCI, Bethesda, MD 20892 USA.
   [Gao, Bo; Yang, Yingzi] NHGRI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3024
DI 10.1158/1538-7445.AM2015-3024
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101073
ER

PT J
AU Haque, I
   Banerjee, S
   Beutler, JA
   Banerjee, SK
AF Haque, Inamul
   Banerjee, Snigdha
   Beutler, John A.
   Banerjee, Sushanta K.
TI Englerin-A prevents invasive phenotypes of renal cell carcinoma by
   reprogramming mesenchymal to epithelial transition: A key mechanism of
   its anticancer properties
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Haque, Inamul; Banerjee, Snigdha; Banerjee, Sushanta K.] Univ Kansas, Med Ctr, VA Med Ctr Kansas City, Kansas City, KS 66103 USA.
   [Beutler, John A.] NCI, Mol Target Lab, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5322
DI 10.1158/1538-7445.AM2015-5322
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105459
ER

PT J
AU Hernandez, LS
   Bradley, A
   Gaiser, T
   Andersson, S
   Gertz, EM
   Chowdhury, SA
   Schwartz, R
   Schaffer, A
   Heselmeyer-Haddad, K
   Ried, T
AF Hernandez, Leanora S.
   Bradley, Amanda
   Gaiser, Timo
   Andersson, Sonia
   Gertz, E. Michael
   Chowdhury, Salim A.
   Schwartz, Russel
   Schaeffer, Alejandro
   Heselmeyer-Haddad, Kerstin
   Ried, Thomas
TI Single-cell genetic analysis reveals insights into clonal development of
   cervical cancer and confirms TERC as an early and dominant aberration
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Hernandez, Leanora S.; Bradley, Amanda; Heselmeyer-Haddad, Kerstin; Ried, Thomas] NCI, Genet Branch, CCR, NIH, Bethesda, MD 20892 USA.
   [Gaiser, Timo] Univ Hosp Mannheim, Mannheim, Germany.
   [Andersson, Sonia] Karolinska Inst, Karolinska Univ Hosp Solna, Stockholm, Sweden.
   [Gertz, E. Michael; Schaeffer, Alejandro] NIH, NCBI, Bethesda, MD 20892 USA.
   [Chowdhury, Salim A.] Carnegie Mellon Univ, Joint Carnegie Mellon Univ Pittsburgh PhD Program, Pittsburgh, PA 15213 USA.
   [Schwartz, Russel] Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA.
RI Schwartz, Russell/A-1998-2016
OI Schwartz, Russell/0000-0002-4970-2252
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4833
DI 10.1158/1538-7445.AM2015-4833
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105020
ER

PT J
AU Ignatius, M
   Lobbardi, R
   Hayes, M
   Chen, E
   McCarthy, K
   Nielsen, GP
   Beleyea, B
   Linardic, C
   Khan, J
   Keller, C
   Langenau, DM
AF Ignatius, Myron
   Lobbardi, Riadh
   Hayes, Madeline
   Chen, Eleanor
   McCarthy, Karin
   Nielsen, G. Petur
   Beleyea, Brian
   Linardic, Corinne
   Khan, Javed
   Keller, Charles
   Langenau, David M.
TI Notch signaling increases the number of relapse-driving tumor
   propagating cells in embryonal rhabdomyosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ignatius, Myron; Lobbardi, Riadh; Hayes, Madeline; Chen, Eleanor; McCarthy, Karin; Nielsen, G. Petur; Langenau, David M.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Charlestown, MA USA.
   [Beleyea, Brian; Linardic, Corinne] Duke Univ, Dept Pharmacol & Canc Biol, Med Ctr, Durham, NC USA.
   [Khan, Javed] NCI, Oncogen Sect, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
   [Keller, Charles] Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, Pediat Canc Biol Program, Portland, OR 97201 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4733
DI 10.1158/1538-7445.AM2015-4733
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104360
ER

PT J
AU Iyer, J
   Peel, N
   O'Rourke, S
   Bowerman, B
   O'Connell, K
AF Iyer, Jyoti
   Peel, Neena
   O'Rourke, Sean
   Bowerman, Bruce
   O'Connell, Kevin
TI Protein phosphatase 1 and the RNA-binding protein CSTL2 function to
   constrain daughter centriole number
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Iyer, Jyoti; O'Connell, Kevin] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Peel, Neena] Coll New Jersey, Ewing, NJ USA.
   [O'Rourke, Sean; Bowerman, Bruce] Univ Oregon, Eugene, OR 97403 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-085
DI 10.1158/1538-7445.AM2015-LB-085
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100188
ER

PT J
AU Jacoby, E
   Yang, YM
   Chien, CD
   Haso, W
   Qin, HY
   Fry, TJ
AF Jacoby, Elad
   Yang, Yinmeng
   Chien, Chris D.
   Haso, Waleed
   Qin, Haiying
   Fry, Terry J.
TI Late ALL relapse following CD19 CAR immune-pressure demonstrates
   reversible pan-antigen loss
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Jacoby, Elad; Yang, Yinmeng; Chien, Chris D.; Haso, Waleed; Qin, Haiying; Fry, Terry J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4705
DI 10.1158/1538-7445.AM2015-4705
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104333
ER

PT J
AU Jeong, W
   Do, K
   Chen, A
   Zlott, J
   Juwara, L
   Horneffer, Y
   Kinders, R
   Wang, LH
   Balasubramanian, P
   Anderson, L
   Sharon, E
   Streicher, H
   Piekarz, R
   Conley, B
   Collins, J
   Doroshow, JH
   Kummar, S
AF Jeong, Woondong
   Do, Khanh
   Chen, Alice
   Zlott, Jennifer
   Juwara, Lamin
   Horneffer, Yvonne
   Kinders, Robert
   Wang, Lihua
   Balasubramanian, Priya
   Anderson, Larry
   Sharon, Elad
   Streicher, Howard
   Piekarz, Richard
   Conley, Barbara
   Collins, Jerry
   Doroshow, James H.
   Kummar, Shivaani
TI A phase I trial of oral TRC102 (methoxyamine HCl) in combination with
   temozolomide (TMZ) in patients with relapsed solid tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Jeong, Woondong; Do, Khanh; Chen, Alice; Horneffer, Yvonne; Anderson, Larry; Sharon, Elad; Streicher, Howard; Piekarz, Richard; Conley, Barbara; Collins, Jerry; Doroshow, James H.; Kummar, Shivaani] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Zlott, Jennifer] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Juwara, Lamin; Kinders, Robert; Wang, Lihua; Balasubramanian, Priya] Leidos Frederick Inc, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA CT316
DI 10.1158/1538-7445.AM2015-CT316
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100088
ER

PT J
AU Jessup, JM
   Mattoo, AR
   Korokhov, N
AF Jessup, J. Milburn
   Mattoo, Abid R.
   Korokhov, Nikolay
TI Targeting NANOG: genes, proteins and response to viral RNAi in
   preclinical models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Jessup, J. Milburn; Mattoo, Abid R.; Korokhov, Nikolay] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4216
DI 10.1158/1538-7445.AM2015-4216
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103300
ER

PT J
AU Kallio, HML
   Annala, M
   Kivinummi, K
   Hognas, G
   Gundem, G
   Wedge, DC
   Van Loo, P
   Heyn, H
   Emmert-Buck, MR
   Isaacs, WB
   Esteller, M
   McDermott, U
   Nykter, M
   Visakorpi, T
   Bova, GS
AF Kallio, Heini M. L.
   Annala, Matti
   Kivinummi, Kati
   Hognas, Gunilla
   Gundem, Gunes
   Wedge, David C.
   Van Loo, Peter
   Heyn, Holger
   Emmert-Buck, Michael R.
   Isaacs, William B.
   Esteller, Manel
   McDermott, Ultan
   Nykter, Matti
   Visakorpi, Tapio
   Bova, G. Steven
TI Clonal evolution of a lethal prostate cancer: Integrated whole genome
   analysis case study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kallio, Heini M. L.; Annala, Matti; Kivinummi, Kati; Hognas, Gunilla; Nykter, Matti; Visakorpi, Tapio; Bova, G. Steven] Univ Tampere, Inst Biosci & Med Technol, BioMediTech, FIN-33101 Tampere, Finland.
   [Kallio, Heini M. L.; Annala, Matti; Kivinummi, Kati; Hognas, Gunilla; Nykter, Matti; Visakorpi, Tapio; Bova, G. Steven] Tampere Univ Hosp, Fimlab Labs, Tampere, Finland.
   [Gundem, Gunes; Wedge, David C.; Van Loo, Peter; McDermott, Ultan] Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton, Cambs, England.
   [Heyn, Holger; Esteller, Manel] Hosp Duran & Reynals, Bellvitge Inst Biomed Res IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona, Spain.
   [Emmert-Buck, Michael R.] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
   [Isaacs, William B.] Johns Hopkins Univ, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3883
DI 10.1158/1538-7445.AM2015-3883
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102407
ER

PT J
AU Karami, S
   Han, YH
   Schumacher, FR
   Kote-Jarai, Z
   Lindstrom, S
   Witte, JS
   Cheng, I
   Fang, SY
   Han, JL
   Kraft, P
   Song, FJ
   Hung, RJ
   McKay, J
   Chanock, SJ
   Pande, M
   Risch, A
   Shen, HB
   Haiman, CA
   Boardman, L
   Ulrich, CM
   Casey, G
   Peters, U
   Chatterjee, N
   Pierce, B
   Zheng, W
   Amos, CI
   Doherty, JA
AF Karami, Sara
   Han, Younghun
   Schumacher, Fredrick R.
   Kote-Jarai, Zsofia
   Lindstrom, Sara
   Witte, John S.
   Cheng, Iona
   Fang, Shenying
   Han, Jiali
   Kraft, Peter
   Song, Fengju
   Hung, Rayjean J.
   McKay, James
   Chanock, Stephen J.
   Pande, Mala
   Risch, Angela
   Shen, Hongbing
   Haiman, Christopher A.
   Boardman, Lisa
   Ulrich, Cornelia M.
   Casey, Graham
   Peters, Ulrike
   Chatterjee, Nilanjan
   Pierce, Brandon
   Zheng, Wei
   Amos, Christopher I.
   Doherty, Jennifer A.
TI Risk loci in telomere structure and maintenance genes across five cancer
   types: GAME-ON Consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Karami, Sara; Han, Younghun; Amos, Christopher I.; Doherty, Jennifer A.] Geisel Sch Med Dartmouth, Dept Epidemiol, Dartmouth, NS, Lebanon.
   [Schumacher, Fredrick R.; Witte, John S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Kote-Jarai, Zsofia] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England.
   [Lindstrom, Sara] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, 665 Huntington Ave, Boston, MA 02115 USA.
   [Cheng, Iona] Canc Prevent Inst Calif, Fremont, CA USA.
   [Fang, Shenying] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
   [Han, Jiali] Indiana Univ, Dept Epidemiol, Richard M Fairbanks Sch Publ Hlth, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA.
   [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Song, Fengju] Tianjin Med Univ, Dept Epidemiol & Biostat, Key Lab Canc Prevent & Therapy, Natl Clin Res Ctr Canc,Canc Inst & Hosp, Tianjin, Peoples R China.
   [Hung, Rayjean J.] Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
   [McKay, James] IARC, Genet Canc Susceptibil Grp, Lyon, France.
   [Chanock, Stephen J.; Chatterjee, Nilanjan] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
   [Pande, Mala] Univ Texas MD Anderson Canc Ctr, Div Internal Med, Houston, TX 77030 USA.
   [Risch, Angela] Salzburg Univ, Div Mol Genet, Dept Mol Biol, A-5020 Salzburg, Austria.
   [Shen, Hongbing] Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China.
   [Haiman, Christopher A.] Univ So Calif, Dept Publ Hlth & Clin Med Nutr Res, Keck Sch Med, Los Angeles, CA USA.
   [Boardman, Lisa] Mayo Clin, Coll Med, Rochester, MN USA.
   [Ulrich, Cornelia M.; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
   [Casey, Graham] Univ So Calif, USC Norris Comprehensve Canc Ctr, Los Angeles, CA USA.
   [Pierce, Brandon] Univ Chicago Biol Sci, Dept Publ Hlth Sci, Chicago, IL USA.
   [Zheng, Wei] Vanderbilt Epidemiol Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.
   [Zheng, Wei] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA.
NR 0
TC 0
Z9 0
U1 4
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4609
DI 10.1158/1538-7445.AM2015-4609
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104237
ER

PT J
AU Kaur, G
   Polley, E
   Morris, J
   Silvers, T
   Selby, M
   Delosh, R
   Laudeman, J
   Ogle, C
   Reinhart, R
   Monks, A
   Rapisarda, A
   Evans, D
   Teicher, BA
AF Kaur, Gurmeet
   Polley, Eric
   Morris, Joel
   Silvers, Thomas
   Selby, Michael
   Delosh, Rene
   Laudeman, Julie
   Ogle, Chad
   Reinhart, Russell
   Monks, Anne
   Rapisarda, Annamaria
   Evans, David
   Teicher, Beverly A.
TI Osteosarcoma cell lines response to approved and investigational
   anticancer agents and statins along with gene and microRNA expression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kaur, Gurmeet] NCI, FNLCR, Frederick, MD 21701 USA.
   [Polley, Eric; Morris, Joel; Teicher, Beverly A.] NCI, Gaithersburg, MD USA.
   [Silvers, Thomas; Selby, Michael; Delosh, Rene; Laudeman, Julie; Ogle, Chad; Reinhart, Russell; Monks, Anne; Rapisarda, Annamaria; Evans, David] Leidos Biomed Res Inc, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5406
DI 10.1158/1538-7445.AM2015-5406
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106065
ER

PT J
AU Kedei, N
   Chen, JQ
   Herrmann, M
   Hu, T
   Chang, K
   Blumberg, PM
AF Kedei, Noemi
   Chen, Jin-Qiu
   Herrmann, Michelle
   Hu, Tiffany
   Chang, Karina
   Blumberg, Peter M.
TI Dramatic differences in the extents and patterns of PKC delta
   modification among the different members of the NCI-60 cancer cell line
   panel
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kedei, Noemi; Chen, Jin-Qiu; Herrmann, Michelle; Hu, Tiffany; Chang, Karina; Blumberg, Peter M.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4977
DI 10.1158/1538-7445.AM2015-4977
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105158
ER

PT J
AU Kim, MKH
   James, J
   Annunziata, C
AF Kim, Marianne K. H.
   James, Jana
   Annunziata, Christina
TI Topotecan synergizes with CHEK1 inhibitor to induce apoptosis in ovarian
   cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kim, Marianne K. H.; James, Jana; Annunziata, Christina] NCI, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3490
DI 10.1158/1538-7445.AM2015-3490
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102031
ER

PT J
AU Kim, S
   Varticoyski, L
   Lao, QZ
   Baek, S
   Sung, MH
   Grontved, L
   Nickerson, ML
   Thompson, B
   Theodorescu, D
   Dean, M
   Hager, GH
AF Kim, Sohyoung
   Varticoyski, Lyuba
   Lao, Qizong
   Baek, Songjoon
   Sung, Myong-Hee
   Grontved, Lars
   Nickerson, Michael L.
   Thompson, Bethtrice
   Theodorescu, Dan
   Dean, Michael
   Hager, Gordon H.
TI Genome-wide chromatin profiling in bladder and prostate cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kim, Sohyoung; Varticoyski, Lyuba; Lao, Qizong; Baek, Songjoon; Sung, Myong-Hee; Nickerson, Michael L.; Dean, Michael; Hager, Gordon H.] NCI, Bethesda, MD 20892 USA.
   [Grontved, Lars] Univ Southern Denmark, Odense M, Denmark.
   [Thompson, Bethtrice] Clarke Atlanta Univ, Atlanta, GA USA.
   [Theodorescu, Dan] Univ Colorado, Dept Pathol, Aurora, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4782
DI 10.1158/1538-7445.AM2015-4782
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104408
ER

PT J
AU Kitano, H
   Chung, JY
   Hanaoka, J
   Inoue, S
   Yoshinori, D
   Fukuoka, J
   Hewitt, SM
AF Kitano, Haruhisa
   Chung, Joon-Yong
   Hanaoka, Jun
   Inoue, Shuhei
   Yoshinori, Doki
   Fukuoka, Junya
   Hewitt, Stephen M.
TI Synaptonemal complex protein 3 is associated with lymphangiogenesis in
   non-small cell lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kitano, Haruhisa; Hanaoka, Jun] Shiga Univ Med Sci, Otsu, Shiga 52021, Japan.
   [Chung, Joon-Yong; Hewitt, Stephen M.] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
   [Inoue, Shuhei] Natl Hosp Org, Higashi Ohmi Gen Med Ctr, Dept Thorac Surg, Higashi Oumi, Japan.
   [Yoshinori, Doki] Toyama Univ, Dept Surg 1, Toyama 930, Japan.
   [Fukuoka, Junya] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki 852, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5184
DI 10.1158/1538-7445.AM2015-5184
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105358
ER

PT J
AU Kumar, S
AF Kumar, Sarvesh
TI Characterization of a novel TIMP-2 deficient mouse model of experimental
   lung metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kumar, Sarvesh] NIH, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4113
DI 10.1158/1538-7445.AM2015-4113
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103202
ER

PT J
AU Lam, C
   Curtis, R
   Dores, G
   Engels, E
   Caporaso, N
   Polliack, A
   Warren, J
   Young, H
   Levine, P
   Elmi, A
   Fraumeni, J
   Tucker, M
   Morton, L
AF Lam, Clara
   Curtis, Rochelle
   Dores, Graca
   Engels, Eric
   Caporaso, Neil
   Polliack, Aaron
   Warren, Joan
   Young, Heather
   Levine, Paul
   Elmi, Angelo
   Fraumeni, Joseph
   Tucker, Margaret
   Morton, Lindsay
TI Risk factors for lung cancer among survivors of non-Hodgkin lymphoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lam, Clara; Curtis, Rochelle; Engels, Eric; Caporaso, Neil; Warren, Joan; Fraumeni, Joseph; Tucker, Margaret; Morton, Lindsay] NCI, Rockville, MD USA.
   [Dores, Graca] Oklahoma City Vet Affairs Hlth Care Syst, Oklahoma City, OK USA.
   [Polliack, Aaron] Hadassah Univ Hosp, IL-91120 Jerusalem, Israel.
   [Young, Heather; Levine, Paul; Elmi, Angelo] George Washington Univ, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-184
DI 10.1158/1538-7445.AM2015-LB-184
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100284
ER

PT J
AU Lane, C
   Kennedy, A
   Brotzman, M
   Miller, A
   Lai, G
   Khoury, M
   Seminara, D
AF Lane, Crystal
   Kennedy, Amy
   Brotzman, Michelle
   Miller, Amy
   Lai, Gabriel
   Khoury, Muin
   Seminara, Daniela
TI Supporting cancer epidemiology research through cohort registration:
   NCI's cancer epidemiology cohort descriptive database
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lane, Crystal; Kennedy, Amy; Lai, Gabriel; Seminara, Daniela] NCI, Rockville, MD USA.
   [Brotzman, Michelle; Miller, Amy] WESTAT Corp, Rockville, MD 20850 USA.
   [Khoury, Muin] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-195
DI 10.1158/1538-7445.AM2015-LB-195
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100294
ER

PT J
AU Le, L
   Schairer, C
   Hablas, A
   Ramadan, M
   Merajver, S
   Seifeldein, I
   Soliman, A
AF Le, Lynne
   Schairer, Catherine
   Hablas, Ahmed
   Ramadan, Mohamed
   Merajver, Sofia
   Seifeldein, Ibrahim
   Soliman, Amr
TI Reliability of medical records in diagnosing inflammatory breast cancer
   in Egypt
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Le, Lynne; Soliman, Amr] Univ Nebraska Med Ctr, Omaha, NE USA.
   [Schairer, Catherine] NCI, Bethesda, MD 20892 USA.
   [Hablas, Ahmed; Ramadan, Mohamed; Seifeldein, Ibrahim] Gharbiah Canc Soc, Giza, Egypt.
   [Merajver, Sofia] Univ Michigan, Ann Arbor, MI 48109 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5590
DI 10.1158/1538-7445.AM2015-5590
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106247
ER

PT J
AU Leikin, JD
   Zingone, A
   Brown, D
   Mitchell, K
   Khan, M
   Vidal, O
   Ryan, B
AF Leikin, Jennie D.
   Zingone, Adriana
   Brown, Derek
   Mitchell, Khadijah
   Khan, Mohammed
   Vidal, Oscar
   Ryan, Brid
TI Analysis of miR-21 isomiRs in lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Leikin, Jennie D.; Zingone, Adriana; Brown, Derek; Mitchell, Khadijah; Khan, Mohammed; Vidal, Oscar; Ryan, Brid] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-295
DI 10.1158/1538-7445.AM2015-LB-295
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100387
ER

PT J
AU Li, HT
   Zhu, F
   Chen, HY
   Cheng, KW
   Zykova, T
   Oi, N
   Lubet, RA
   Bode, AM
   Wang, MF
   Dong, ZG
AF Li, Haitao
   Zhu, Feng
   Chen, Hanyong
   Cheng, Ka Wing
   Zykova, Tatyana
   Oi, Naomi
   Lubet, Ronald A.
   Bode, Ann M.
   Wang, Mingfu
   Dong, Zigang
TI 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by
   inhibiting cyclooxygenase-1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Li, Haitao; Zhu, Feng; Chen, Hanyong; Zykova, Tatyana; Oi, Naomi; Bode, Ann M.; Dong, Zigang] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA.
   [Cheng, Ka Wing; Wang, Mingfu] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
   [Lubet, Ronald A.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 1
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4573
DI 10.1158/1538-7445.AM2015-4573
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104201
ER

PT J
AU Li, HZ
   Chen, Y
   Liu, WL
   Zhu, JQ
   Kay, C
   Wang, XJ
   Rodgers, GP
AF Li, Hongzhen
   Chen, Ye
   Liu, Wenli
   Zhu, Jianqiong
   Kay, Chin
   Wang, Xujing
   Rodgers, Griffin P.
TI Olfactomedin 4 plays a tumor-suppressor role and is a novel candidate
   biomarker in the prostate cancer progression and independent of PSA
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Li, Hongzhen; Chen, Ye; Liu, Wenli; Zhu, Jianqiong; Kay, Chin; Wang, Xujing; Rodgers, Griffin P.] NHLBI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4344
DI 10.1158/1538-7445.AM2015-4344
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103426
ER

PT J
AU Lian, M
   Liu, XQ
   Han, DM
   Fang, JG
   Chen, Z
AF Lian, Meng
   Liu, Xiaoqin
   Han, Demin
   Fang, Jugao
   Chen, Zhong
TI Array profiling identified upregulated miRNAs and target genes and
   pathways in laryngeal squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lian, Meng; Han, Demin; Fang, Jugao] Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China.
   [Liu, Xiaoqin] Peoples Hosp, Dept Otolaryngol, Shanghai, Inner Mongolia, Peoples R China.
   [Chen, Zhong] Natl Inst Deafness & Commun Disorders, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4001
DI 10.1158/1538-7445.AM2015-4001
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103095
ER

PT J
AU Liu, F
   Xie, W
   Liu, ZX
   Roy, T
   Bae, E
   Wakefield, LM
   Kim, SJ
   Ooshima, A
   Reiss, M
   Matsuura, I
AF Liu, Fang
   Xie, Wen
   Liu, Zhengxue
   Roy, Tanima
   Bae, Eunjin
   Wakefield, Lalage M.
   Kim, Seong-Jin
   Ooshima, Akira
   Reiss, Michael
   Matsuura, Isao
TI Role of Smad3 linker phosphorylation in breast cancer progression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Liu, Fang; Liu, Zhengxue; Roy, Tanima] Rutgers State Univ, Piscataway, NJ USA.
   [Xie, Wen; Reiss, Michael] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA.
   [Bae, Eunjin; Kim, Seong-Jin; Ooshima, Akira] CHA Canc Res Inst, Seoul, South Korea.
   [Wakefield, Lalage M.] NCI, Bethesda, MD 20892 USA.
   [Matsuura, Isao] Natl Hlth Res Inst, Taipei, Taiwan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4940
DI 10.1158/1538-7445.AM2015-4940
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105121
ER

PT J
AU Liu, JJ
   Morton, LM
   de Gonzalez, AB
   Inskip, PD
   Curtis, RE
AF Liu, Jason J.
   Morton, Lindsay M.
   de Gonzalez, Amy Berrington
   Inskip, Peter D.
   Curtis, Rochelle E.
TI Subsequent gastrointestinal cancer risks of childhood and early
   adulthood cancer survivors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Liu, Jason J.; Morton, Lindsay M.; de Gonzalez, Amy Berrington; Inskip, Peter D.; Curtis, Rochelle E.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3725
DI 10.1158/1538-7445.AM2015-3725
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102262
ER

PT J
AU Liu, YH
   Kheradmand, F
   Scheurer, M
   Davis, C
   Wheeler, D
   Silverman, E
   Sanjay, S
   Tsavachidis, S
   Armstrong, G
   Kupert, E
   Anderson, M
   Li, YF
   Pikielny, C
   Bailey-Wilson, JE
   You, M
   Gaba, C
   DeAndrade, M
   Mandal, D
   Simpson, C
   Pinney, S
   Amos, C
   Spitz, M
AF Liu, Yanhong
   Kheradmand, Farrah
   Scheurer, Michael
   Davis, Caleb
   Wheeler, David
   Silverman, Edwin
   Sanjay, Shete
   Tsavachidis, Spiridon
   Armstrong, Georgina
   Kupert, Elena
   Anderson, Marshall
   Li, Yafang
   Pikielny, Claudio
   Bailey-Wilson, Joan E.
   You, Ming
   Gaba, Colette
   DeAndrade, Mariza
   Mandal, Diptasri
   Simpson, Claire
   Pinney, Susan
   Amos, Christopher
   Spitz, Margaret
TI Target exome sequencing for disease-causing rare mutations in familial
   and sporadic lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Liu, Yanhong; Kheradmand, Farrah; Scheurer, Michael; Davis, Caleb; Wheeler, David; Tsavachidis, Spiridon; Armstrong, Georgina; Spitz, Margaret] Baylor Coll Med, Houston, TX 77030 USA.
   [Silverman, Edwin] Harvard Univ, Sch Med, Boston, MA USA.
   [Sanjay, Shete] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Kupert, Elena; Pinney, Susan] Univ Cincinnati, Cincinnati, OH USA.
   [Anderson, Marshall; You, Ming] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Li, Yafang; Amos, Christopher] Dartmouth Hitchcock Norris Cotton Canc Ctr, Manchester, NH USA.
   [Pikielny, Claudio] Dartmouth Med Sch, Hanover, NH 03755 USA.
   [Bailey-Wilson, Joan E.] NHGRI, Bethesda, MD 20892 USA.
   [Gaba, Colette] Univ Toledo, Toledo, OH 43606 USA.
   [DeAndrade, Mariza] Mayo Clin, Rochester, MN 55905 USA.
   [Mandal, Diptasri] Louisiana State Univ, Hlth Sci Ctr, Baton Rouge, LA 70803 USA.
   [Simpson, Claire] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4600
DI 10.1158/1538-7445.AM2015-4600
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104228
ER

PT J
AU Long, AH
   Haso, WM
   Smith, JP
   Walker, AJ
   Fry, TJ
   Orentas, RJ
   Mackall, CL
AF Long, Adrienne H.
   Haso, Waleed M.
   Smith, Jillian P.
   Walker, Alec J.
   Fry, Terry J.
   Orentas, Rimas J.
   Mackall, Crystal L.
TI 4-1BB costimulation ameliorates exhaustion and prolongs in vivo
   persistence of chimeric antigen receptor (CAR) expressing T cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Long, Adrienne H.] Northwestern Univ, NIH, Bethesda, MD USA.
   [Haso, Waleed M.; Smith, Jillian P.; Walker, Alec J.; Fry, Terry J.; Orentas, Rimas J.; Mackall, Crystal L.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4702
DI 10.1158/1538-7445.AM2015-4702
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104330
ER

PT J
AU LoRusso, PM
   Tolaney, SM
   Wong, S
   Parchment, RE
   Kinders, RJ
   Wang, LH
   Aldrich, J
   Chen, A
   Durecki, D
   Boerner, SA
   Guthrie, T
   Bowditch, A
   Heilbrun, LK
   Pilat, MJ
   Craig, D
   Cai, DP
   Bell, T
   Carpten, J
   Shapiro, G
AF LoRusso, Patricia M.
   Tolaney, Sara M.
   Wong, Shukmei
   Parchment, Ralph E.
   Kinders, Robert J.
   Wang, Lihua
   Aldrich, Jessica
   Chen, Alice
   Durecki, Diane
   Boerner, Scott A.
   Guthrie, Tina
   Bowditch, Adam
   Heilbrun, Lance K.
   Pilat, Mary Jo
   Craig, David
   Cai, Dongpo
   Bell, Tracy
   Carpten, John
   Shapiro, Geoffrey
TI Combination of the PARP inhibitor veliparib (ABT888) with irinotecan in
   patients with triple negative breast cancer: Preliminary activity and
   signature of response
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [LoRusso, Patricia M.; Durecki, Diane; Boerner, Scott A.] Yale Canc Ctr, New Haven, CT USA.
   [Tolaney, Sara M.; Cai, Dongpo; Bell, Tracy; Shapiro, Geoffrey] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Wong, Shukmei; Aldrich, Jessica; Craig, David; Carpten, John] Translat Genom Res Inst, Phoenix, AZ USA.
   [Parchment, Ralph E.; Kinders, Robert J.; Wang, Lihua] Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Chen, Alice] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Guthrie, Tina; Bowditch, Adam; Heilbrun, Lance K.] Karmanos Canc Inst, Detroit, MI USA.
   [Pilat, Mary Jo] Wayne State Univ, Detroit, MI USA.
NR 0
TC 3
Z9 3
U1 4
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA CT325
DI 10.1158/1538-7445.AM2015-CT325
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100097
ER

PT J
AU LoVerso, PR
   Zhurki, VB
   Cui, F
AF LoVerso, Peter R.
   Zhurki, Victor B.
   Cui, Feng
TI Nucleosome organization and accessibility of p53 response elements in
   the chromatin context
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [LoVerso, Peter R.; Cui, Feng] Rochester Inst Technol, Rochester, NY 14623 USA.
   [Zhurki, Victor B.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4780
DI 10.1158/1538-7445.AM2015-4780
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104406
ER

PT J
AU Lowy, DR
AF Lowy, Douglas R.
TI Drastically reducing HPV-associated cancers through etiologically-based
   primary and secondary prevention
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lowy, Douglas R.] NCI, Cellular Oncol Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA PL02-04
DI 10.1158/1538-7445.AM2015-PL02-04
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100410
ER

PT J
AU Ma, C
   Felsher, D
   Greten, T
AF Ma, Chi
   Felsher, Dean
   Greten, Tim
TI The role of CD4 T cells in murine model of NASH-promoted HCC
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ma, Chi; Greten, Tim] NCI, NIH, Bethesda, MD 20892 USA.
   [Felsher, Dean] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3166
DI 10.1158/1538-7445.AM2015-3166
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101201
ER

PT J
AU Ma, K
   Ryan, P
   Klevit, R
   Lipkowitz, S
AF Ma, Ke
   Ryan, Philip
   Klevit, Rachel
   Lipkowitz, Stanley
TI Multiple ubiquitin-conjugating enzymes modulate the ubiquitination and
   downregulation of the EGFR by the Cbl RING finger ubiquitin ligase
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ma, Ke; Ryan, Philip; Lipkowitz, Stanley] NCI, NIH, Bethesda, MD 20892 USA.
   [Klevit, Rachel] Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4965
DI 10.1158/1538-7445.AM2015-4965
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105146
ER

PT J
AU Madka, V
   Mohammed, A
   Li, Q
   Zhang, YT
   Biddick, L
   Patlolla, JMR
   Lightfoot, S
   Wu, XR
   Steele, V
   Kopelovich, L
   Rao, CV
AF Madka, Venkateshwar
   Mohammed, Altaf
   Li, Qian
   Zhang, Yuting
   Biddick, Laura
   Patlolla, Jagan M. R.
   Lightfoot, Stanley
   Wu, Xue-Ru
   Steele, Vernon
   Kopelovich, Levy
   Rao, Chinthalapally V.
TI Modulation of mTOR and p53 signaling using rapamycin plus CP-31398
   inhibits growth and progression of urothelial carcinoma in-vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Madka, Venkateshwar; Mohammed, Altaf; Li, Qian; Zhang, Yuting; Biddick, Laura; Patlolla, Jagan M. R.; Lightfoot, Stanley; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Wu, Xue-Ru] NYU Langone Med Ctr, New York, NY USA.
   [Steele, Vernon] NCI, Rockville, MD USA.
   [Kopelovich, Levy] Cornell Univ, Weill Cornell Med Coll, Ithaca, NY 14853 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4653
DI 10.1158/1538-7445.AM2015-4653
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104281
ER

PT J
AU Mani, R
   Chiang, CL
   Frissora, FW
   Yan, RB
   Mo, XK
   Baskar, S
   Rader, C
   Phelps, M
   Chen, CS
   Lee, R
   Byrd, J
   Baiocchi, R
   Lee, LJ
   Muthusamy, N
AF Mani, Rajeswaran
   Chiang, Chi-Ling
   Frissora, Frank W.
   Yan, Ribai
   Mo, Xiaokui
   Baskar, Sivasubramanian
   Rader, Christoph
   Phelps, Mitch
   Chen, Ching-Shih
   Lee, Robert
   Byrd, John
   Baiocchi, Robert
   Lee, L. James
   Muthusamy, Natarajan
TI ROR1 targeted delivery of OSU-2S, a non-immunosuppressive FTY720
   derivative, exerts potent cytotoxicity in mantle cell lymphoma in-vitro
   and in-vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mani, Rajeswaran; Chiang, Chi-Ling; Frissora, Frank W.; Yan, Ribai; Mo, Xiaokui; Phelps, Mitch; Chen, Ching-Shih; Lee, Robert; Byrd, John; Baiocchi, Robert; Lee, L. James; Muthusamy, Natarajan] Ohio State Univ, Columbus, OH 43210 USA.
   [Baskar, Sivasubramanian] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Rader, Christoph] Scripps Res Inst, Jupiter, FL USA.
RI Chiang, Chi-Ling/O-3038-2016
OI Chiang, Chi-Ling/0000-0002-0275-9673
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4406
DI 10.1158/1538-7445.AM2015-4406
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104038
ER

PT J
AU Masuda, J
   Kitani, A
   Fuss, I
   Seno, M
   Strober, W
AF Masuda, Junko
   Kitani, Atsuhi
   Fuss, Ivan
   Seno, Masaharu
   Strober, Warren
TI Dextran sodium sulfate-induced colitis in dendritic cell deletion mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Masuda, Junko; Seno, Masaharu] Okayama Univ, Okayama 7008530, Japan.
   [Kitani, Atsuhi; Fuss, Ivan; Strober, Warren] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4296
DI 10.1158/1538-7445.AM2015-4296
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103380
ER

PT J
AU McMaster, ML
   Goldin, LR
   Caporaso, NE
AF McMaster, Mary L.
   Goldin, Lynn R.
   Caporaso, Neil E.
TI Second cancers following Waldenstrom macroglobulinemia/lymphoplasmacytic
   lymphoma in the United States: analysis of Surveillance, Epidemiology
   and End Results (SEER) registry data, 1992-2011
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [McMaster, Mary L.; Goldin, Lynn R.; Caporaso, Neil E.] NCI DCEG, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3709
DI 10.1158/1538-7445.AM2015-3709
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102247
ER

PT J
AU Mehta, M
   Griffith, J
   Basalingappa, K
   Babu, A
   Amreddy, N
   Muralidharan, R
   Gorospe, M
   Herman, T
   Ding, WQ
   Ramesh, R
   Munshi, A
AF Mehta, Meghna
   Griffith, James
   Basalingappa, Kanthesh
   Babu, Anish
   Amreddy, Narsireddy
   Muralidharan, Ranganayaki
   Gorospe, Myriam
   Herman, Terence
   Ding, Wei-Qun
   Ramesh, Rajagopal
   Munshi, Anupama
TI The RNA-binding protein HuR radiosensitizes human TNBC cells by
   modulating the cellular response to DNA damage and oxidative stress
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mehta, Meghna; Griffith, James; Basalingappa, Kanthesh; Babu, Anish; Amreddy, Narsireddy; Muralidharan, Ranganayaki; Herman, Terence; Ding, Wei-Qun; Ramesh, Rajagopal; Munshi, Anupama] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Gorospe, Myriam] NIA, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3306
DI 10.1158/1538-7445.AM2015-3306
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101335
ER

PT J
AU Merchant, MS
   D'Angelo, SP
   Zhang, H
   Bernstein, D
   Binder-Scholl, G
   Holdich, T
   Melchiori, L
   Williams, D
   Fortin, M
   Peretz, Y
   Howe, J
   Mehler, M
   Hug, BA
   Wright, M
   Grupp, S
   Meyers, PA
   Tap, W
   Jakobsen, B
   Mackall, CL
AF Merchant, Melinda S.
   D'Angelo, Sandra P.
   Zhang, Hua
   Bernstein, Donna
   Binder-Scholl, Gwen
   Holdich, Tom
   Melchiori, Luca
   Williams, Dan
   Fortin, Marylene
   Peretz, Yoav
   Howe, Jason
   Mehler, Michael
   Hug, Bruce A.
   Wright, Matthew
   Grupp, Stephen
   Meyers, Paul A.
   Tap, William
   Jakobsen, Bent
   Mackall, Crystal L.
TI Genetically engineered NY-ESO-1-specific T cells in HLA-A2+patients with
   synovial sarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Merchant, Melinda S.; Zhang, Hua; Bernstein, Donna; Wright, Matthew; Mackall, Crystal L.] NCI, Bethesda, MD 20892 USA.
   [D'Angelo, Sandra P.; Meyers, Paul A.; Tap, William] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Binder-Scholl, Gwen; Holdich, Tom; Melchiori, Luca; Williams, Dan; Jakobsen, Bent] Adaptimmune, Oxford, England.
   [Fortin, Marylene; Peretz, Yoav] Immunecarta, Montreal, PQ, Canada.
   [Howe, Jason; Mehler, Michael] Adaptimmune, Philadelphia, PA USA.
   [Hug, Bruce A.] GSK, Collegeville, PA USA.
   [Grupp, Stephen] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
NR 0
TC 1
Z9 1
U1 2
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4707
DI 10.1158/1538-7445.AM2015-4707
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104335
ER

PT J
AU Mertins, P
   Mani, DR
   Clauser, K
   Gillette, M
   Wang, P
   Qiao, JN
   Fenyo, D
   Ruggles, K
   Davies, S
   Zhang, B
   Gatza, M
   Wang, SA
   Yan, P
   Lin, CW
   McLellan, M
   Townsend, R
   Ding, L
   Cao, S
   Rodriguez, H
   Paulovich, A
   Ellis, M
   Carr, SA
AF Mertins, Philipp
   Mani, D. R.
   Clauser, Karl
   Gillette, Michael
   Wang, Pei
   Qiao, Jana
   Fenyo, David
   Ruggles, Kelly
   Davies, Sherri
   Zhang, Bing
   Gatza, Michael
   Wang, Sean
   Yan, Ping
   Lin, Chenwei
   McLellan, Michael
   Townsend, Reid
   Ding, Li
   Cao, Song
   Rodriguez, Henry
   Paulovich, Amanda
   Ellis, Matthew
   Carr, Steven A.
CA CPTAC
TI Proteogenomic and phosphoproteomic analysis of breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mertins, Philipp; Mani, D. R.; Clauser, Karl; Gillette, Michael; Qiao, Jana; Carr, Steven A.] Broad Inst MIT & Harvard, Cambridge, MA USA.
   [Wang, Pei] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Fenyo, David; Ruggles, Kelly] NYU, Langone Med Ctr, New York, NY USA.
   [Davies, Sherri; McLellan, Michael; Townsend, Reid; Ding, Li; Cao, Song] Washington Univ, St Louis, MO USA.
   [Zhang, Bing] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Gatza, Michael] Univ N Carolina, Chapel Hill, NC USA.
   [Wang, Sean; Yan, Ping; Lin, Chenwei; Paulovich, Amanda] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Rodriguez, Henry] NCI, Bethesda, MD 20892 USA.
   [Ellis, Matthew] Baylor Coll Med, Houston, TX 77030 USA.
OI Fenyo, David/0000-0001-5049-3825; Ruggles, Kelly/0000-0002-0152-0863
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA SY44-02
DI 10.1158/1538-7445.AM2015-SY44-02
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101036
ER

PT J
AU Mirabello, LJ
   Yeager, M
   Mai, PL
   Gastier-Foster, J
   Gorlick, R
   Khanna, C
   Patino-Garcia, A
   Sierrasesumaga, L
   Lecanda, F
   Andrulis, IL
   Wunder, JS
   Gokgoz, N
   Barkauskas, DA
   Zhang, XJ
   Vogt, A
   Jones, K
   Boland, JF
   Chanock, SJ
   Savage, SA
AF Mirabello, Lisa J.
   Yeager, Meredith
   Mai, Phuong L.
   Gastier-Foster, Julie
   Gorlick, Richard
   Khanna, Chand
   Patino-Garcia, Ana
   Sierrasesumaga, Luis
   Lecanda, Fernando
   Andrulis, Irene L.
   Wunder, Jay S.
   Gokgoz, Nalan
   Barkauskas, Donald A.
   Zhang, Xijun
   Vogt, Aurelie
   Jones, Kristine
   Boland, Joseph F.
   Chanock, Stephen J.
   Savage, Sharon A.
TI High prevalence of germline TP53 mutations in young osteosarcoma cases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mirabello, Lisa J.; Mai, Phuong L.; Chanock, Stephen J.; Savage, Sharon A.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
   [Yeager, Meredith; Zhang, Xijun; Vogt, Aurelie; Jones, Kristine; Boland, Joseph F.] Leidos Biomed Res, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Gastier-Foster, Julie] Nationwide Childrens Hosp, Columbus, OH USA.
   [Gastier-Foster, Julie] Ohio State Univ, Dept Pathol & Pediat, Columbus, OH 43210 USA.
   [Gorlick, Richard] Childrens Hosp, Albert Einstein Coll Med, Montefiore, NY USA.
   [Khanna, Chand] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Patino-Garcia, Ana; Sierrasesumaga, Luis; Lecanda, Fernando] Univ Navarra, Univ Navarra Clin, Dept Pediat, E-31080 Pamplona, Spain.
   [Andrulis, Irene L.; Wunder, Jay S.; Gokgoz, Nalan] Univ Toronto, Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst, Mt Sinai Hosp, Toronto, ON M5S 1A1, Canada.
   [Barkauskas, Donald A.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5574
DI 10.1158/1538-7445.AM2015-5574
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106233
ER

PT J
AU Mohan, R
   Gangjee, A
   Bai, RL
   Hamel, E
AF Mohan, Rishabh
   Gangjee, Aleem
   Bai, Ruoli
   Hamel, Ernest
TI Substituted monocyclic pyrimidines as potent tubulin inhibitors that
   circumvent P-glycoprotein mediated resistance
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mohan, Rishabh; Gangjee, Aleem] Duquesne Univ, Pittsburgh, PA 15219 USA.
   [Bai, Ruoli; Hamel, Ernest] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,Frederick Natl Lab Canc, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4553
DI 10.1158/1538-7445.AM2015-4553
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104180
ER

PT J
AU Moody, TW
   Jensen, RT
   Thomas, K
   Fairfull-Smith, KE
   Bottle, SE
   Ridnour, L
   Wink, DA
AF Moody, Terry W.
   Jensen, Robert T.
   Thomas, Komba
   Fairfull-Smith, Kathryn E.
   Bottle, Steven E.
   Ridnour, Lisa
   Wink, David A.
TI Nitroxide-aspirin conjugates: A new class of NSAIDs
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Moody, Terry W.] NCI, CCR, Bethesda, MD 20892 USA.
   [Jensen, Robert T.] NIDDK, Bethesda, MD 20892 USA.
   [Thomas, Komba; Fairfull-Smith, Kathryn E.; Bottle, Steven E.] Queensland Univ Technol, Brisbane, Qld 4001, Australia.
   [Ridnour, Lisa; Wink, David A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4539
DI 10.1158/1538-7445.AM2015-4539
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104166
ER

PT J
AU Mueller, F
   Liu, XF
   Wayne, A
   Pastan, I
AF Mueller, Fabian
   Liu, XiuFen
   Wayne, Alan
   Pastan, Ira
TI Optimized treatment schedule with the new generation CD22-targeting
   immunotoxin LMB11 induces near MRD-negativity in an ALL mouse model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mueller, Fabian; Liu, XiuFen; Pastan, Ira] NIH, Bethesda, MD 20892 USA.
   [Wayne, Alan] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3277
DI 10.1158/1538-7445.AM2015-3277
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101306
ER

PT J
AU Mullendore, M
   Stockwin, LH
   Bonomi, C
   Dougherty, K
   Stotler, H
   Kimmel, A
   Das, B
   Datta, V
   Lih, J
   Williams, M
   Doroshow, J
   Hollingshead, M
   Newton, DL
AF Mullendore, Michael
   Stockwin, Luke H.
   Bonomi, Carrie
   Dougherty, Kelly
   Stotler, Howard
   Kimmel, Adrienne
   Das, Biswajit
   Datta, Vivekananda
   Lih, Jason
   Williams, Mickie
   Doroshow, James
   Hollingshead, Melinda
   Newton, Dianne Lynn
TI Clonal heterogeneity in patient-derived xenografts: The SCLC model
   LG0904F1496M23 contains stable clones with epithelial or mesenchymal
   characteristics and differential drug sensitivities
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mullendore, Michael; Stockwin, Luke H.; Bonomi, Carrie; Dougherty, Kelly; Stotler, Howard; Kimmel, Adrienne; Das, Biswajit; Datta, Vivekananda; Lih, Jason; Williams, Mickie; Newton, Dianne Lynn] Leidos Biomed Res Inc, Frederick, MD USA.
   [Doroshow, James; Hollingshead, Melinda] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3236
DI 10.1158/1538-7445.AM2015-3236
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101267
ER

PT J
AU Nakagawa, M
   Schmitz, R
   Xiao, WM
   Goldman, CK
   Xu, WH
   Yang, YD
   Yu, X
   Waldmann, TA
   Staudt, LM
AF Nakagawa, Masao
   Schmitz, Roland
   Xiao, Wenming
   Goldman, Carolyn K.
   Xu, Weihong
   Yang, Yandan
   Yu, Xin
   Waldmann, Thomas A.
   Staudt, Louis M.
TI Frequent gain-of-function CCR4 mutations in adult T-cell
   leukemia/lymphoma (ATLL)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Nakagawa, Masao; Schmitz, Roland; Xiao, Wenming; Goldman, Carolyn K.; Xu, Weihong; Yang, Yandan; Yu, Xin; Waldmann, Thomas A.; Staudt, Louis M.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3936
DI 10.1158/1538-7445.AM2015-3936
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103033
ER

PT J
AU Navas, T
   Pfister, TD
   Lawrence, SM
   Srivastava, AK
   Kinders, RJ
   Borgel, S
   Alcoser, S
   Hollingshead, MG
   Dutko, LM
   Gouker, BA
   Butcher, D
   Ng-Eaton, E
   Takebe, N
   Lee, YH
   Bottaro, DP
   Parchment, RE
   Tomaszewski, JE
   Doroshow, JH
AF Navas, Tony
   Pfister, Thomas D.
   Lawrence, Scott M.
   Srivastava, Apurva K.
   Kinders, Robert J.
   Borgel, Suzanne
   Alcoser, Sergio
   Hollingshead, Melinda G.
   Dutko, Lindsay M.
   Gouker, Brad A.
   Butcher, Donna
   Ng-Eaton, Elinor
   Takebe, Naoko
   Lee, Young H.
   Bottaro, Donald P.
   Parchment, Ralph E.
   Tomaszewski, Joseph E.
   Doroshow, James H.
TI Impact of HGF knockin microenvironment on epithelial-mesenchymal
   transition and cancer stem cells in a non-small cell lung cancer
   xenograft model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Navas, Tony; Pfister, Thomas D.; Lawrence, Scott M.; Srivastava, Apurva K.; Kinders, Robert J.; Parchment, Ralph E.] Frederick Natl Labs, Lab Human Toxicol & Pharmacol, Appl Dev Directorate, Leidos Biomed Res, Frederick, MD USA.
   [Borgel, Suzanne; Alcoser, Sergio; Hollingshead, Melinda G.] NCI, Biol Testing Branch, Dev Therapeut Program, Frederick Natl Labs, Frederick, MD 21701 USA.
   [Dutko, Lindsay M.; Gouker, Brad A.; Butcher, Donna] Leidos Biomed Res, Pathol Histotechnol Lab, Lab Anim Sci Program, Frederick, MD USA.
   [Ng-Eaton, Elinor] MIT, Dept Biol, Ludwig Ctr Mol Oncol, Whitehead Inst, Cambridge, MA USA.
   [Takebe, Naoko; Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Takebe, Naoko; Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Lee, Young H.; Bottaro, Donald P.] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5082
DI 10.1158/1538-7445.AM2015-5082
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105260
ER

PT J
AU Nayar, U
   Reichel, J
   Sadek, J
   Hernandez-Hopkins, D
   Akar, G
   Zhou, HF
   Sahai, MA
   Barelli, P
   Guasparri, I
   Totonchy, J
   Hassane, D
   Sei, S
   Shoemaker, RH
   Warren, JD
   Elemento, O
   Kaye, KM
   Cesarman, E
AF Nayar, Utthara
   Reichel, Jonathan
   Sadek, Jouliana
   Hernandez-Hopkins, Denise
   Akar, Gunkut
   Zhou, Hufeng
   Sahai, Michelle A.
   Barelli, Peter
   Guasparri, Ilaria
   Totonchy, Jennifer
   Hassane, Duane
   Sei, Shizuko
   Shoemaker, Robert H.
   Warren, J. David
   Elemento, Olivier
   Kaye, Kenneth M.
   Cesarman, Ethel
TI Genomics-based resistome analysis revealed endogenous adenosine kinase
   levels as a chief determinant of specificity for a novel nucleoside
   analog lymphoma inhibitor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Nayar, Utthara; Reichel, Jonathan; Sadek, Jouliana; Hernandez-Hopkins, Denise; Akar, Gunkut; Barelli, Peter; Guasparri, Ilaria; Totonchy, Jennifer; Hassane, Duane; Warren, J. David; Elemento, Olivier; Cesarman, Ethel] Weill Cornell Med Coll, New York, NY USA.
   [Zhou, Hufeng; Kaye, Kenneth M.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Sahai, Michelle A.] Univ Roehampton, London, England.
   [Sei, Shizuko; Shoemaker, Robert H.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4496
DI 10.1158/1538-7445.AM2015-4496
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104124
ER

PT J
AU Olanich, ME
   Sun, WY
   Hewitt, SM
   Abdullaev, Z
   Pack, SD
   Barr, FG
AF Olanich, Mary E.
   Sun, Wenyue
   Hewitt, Stephen M.
   Abdullaev, Zied
   Pack, Svetlana D.
   Barr, Frederic G.
TI CDK4 amplification reduces sensitivity to CDK4/6 inhibition in
   fusion-positive rhabdomyosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Olanich, Mary E.; Sun, Wenyue; Hewitt, Stephen M.; Abdullaev, Zied; Pack, Svetlana D.; Barr, Frederic G.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3093
DI 10.1158/1538-7445.AM2015-3093
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101137
ER

PT J
AU Pan, P
   Skaer, C
   Stirdivant, S
   Young, MR
   Stoner, G
   Lechner, J
   Huang, YW
   Wang, LS
AF Pan, Pan
   Skaer, Chad
   Stirdivant, Steven
   Young, Matthew R.
   Stoner, Gary
   Lechner, John
   Huang, Yi-Wen
   Wang, Li-Shu
TI Beneficial regulation of metabolic profiles by black raspberries in
   human colorectal cancer patients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pan, Pan; Skaer, Chad; Stoner, Gary; Lechner, John; Huang, Yi-Wen; Wang, Li-Shu] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Stirdivant, Steven] Metabolon Inc, Durham, NC USA.
   [Young, Matthew R.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-275
DI 10.1158/1538-7445.AM2015-LB-275
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100368
ER

PT J
AU Pandey, PR
   Hewitt, SM
   Miettinen, MM
   Barr, FG
AF Pandey, Puspa R.
   Hewitt, Stephen M.
   Miettinen, Markku M.
   Barr, Frederic G.
TI PAX3-FOXO1 is essential for initiation but not for recurrence during
   rhabdomyosarcoma tumorigenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pandey, Puspa R.; Hewitt, Stephen M.; Miettinen, Markku M.; Barr, Frederic G.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3273
DI 10.1158/1538-7445.AM2015-3273
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101302
ER

PT J
AU Pandya, H
   Ichikawa, DM
   Shen, MJ
   Sedlock, AB
   Johnson, KR
   Maric, D
   McGavern, DB
   Malech, HL
   Park, JK
AF Pandya, Hetal
   Ichikawa, David M.
   Shen, Michael J.
   Sedlock, Andrea B.
   Johnson, Kory R.
   Maric, Dragan
   McGavern, Dorian B.
   Malech, Harry L.
   Park, John K.
TI Microglia differentiated from induced pluripotent stem cells treat
   glioma tumors in mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pandya, Hetal; Ichikawa, David M.; Shen, Michael J.; Sedlock, Andrea B.; Johnson, Kory R.; Maric, Dragan; McGavern, Dorian B.; Malech, Harry L.; Park, John K.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5029
DI 10.1158/1538-7445.AM2015-5029
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105209
ER

PT J
AU Patel, AS
   Li, TW
   Anreddy, N
   Zhao, YF
   Kathawala, RJ
   Wang, YJ
   Ambudkar, SV
   Chen, ZS
   Cheng, CM
AF Patel, Atish S.
   Li, Tianwen
   Anreddy, Nagaraju
   Zhao, Yufen
   Kathawala, Rishil J.
   Wang, Yijun
   Ambudkar, Suresh V.
   Chen, Zhe-Sheng
   Cheng, Changmei
TI Design, synthesis and biological evaluation of
   N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide analog as a
   promising inhibitor of the multidrug resistance-linked ABCG2 transporter
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Patel, Atish S.; Ambudkar, Suresh V.] NCI, Bethesda, MD 20892 USA.
   [Li, Tianwen; Zhao, Yufen; Cheng, Changmei] Tsinghua Univ, Beijing, Peoples R China.
   [Anreddy, Nagaraju; Kathawala, Rishil J.; Wang, Yijun; Chen, Zhe-Sheng] St Johns Univ, Quenns, NY USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4419
DI 10.1158/1538-7445.AM2015-4419
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104050
ER

PT J
AU Percy-Laurry, A
AF Percy-Laurry, Antoinette
TI Socioeconomic status and the aggressiveness of prostate cancer among
   black males
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Percy-Laurry, Antoinette] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-277
DI 10.1158/1538-7445.AM2015-LB-277
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100370
ER

PT J
AU Pine, PS
   Sorbara, LR
   Srivastava, S
   Salit, M
AF Pine, P. Scott
   Sorbara, Lynn R.
   Srivastava, Sudhir
   Salit, Marc
TI miRNA reference samples for interlaboratory study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pine, P. Scott; Salit, Marc] NIST JIMB, Stanford, CA USA.
   [Sorbara, Lynn R.; Srivastava, Sudhir] NCI, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3967
DI 10.1158/1538-7445.AM2015-3967
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103061
ER

PT J
AU Porter, BE
   Moore, JE
   Miller, MS
   Tallant, EA
   Gallagher, PE
AF Porter, Brooke E.
   Moore, Joseph E.
   Miller, Mark S.
   Tallant, E. Ann
   Gallagher, Patricia E.
TI Muscadine grape extract reduces lung carcinogenesis in female mice
   exposed to 3-methylcholanthrene in utero
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Porter, Brooke E.; Moore, Joseph E.; Tallant, E. Ann; Gallagher, Patricia E.] Wake Forest Sch Med, Winston Salem, NC USA.
   [Miller, Mark S.] NCI, Div Canc Prevent, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4563
DI 10.1158/1538-7445.AM2015-4563
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104191
ER

PT J
AU Qadir, XV
   Clyne, M
   Lam, TK
   Khoury, MJ
   Schully, SD
AF Qadir, Ximena V.
   Clyne, Mindy
   Lam, Tram K.
   Khoury, Muin J.
   Schully, Sheri D.
TI The landscape of published cancer meta-analyses: a descriptive look from
   2008-2013
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Qadir, Ximena V.; Clyne, Mindy; Lam, Tram K.; Schully, Sheri D.] NCI, NIH, Div Canc Control & Populat Sci, Epidemiol & Genom Res Program, Rockville, MD USA.
   [Khoury, Muin J.] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3698
DI 10.1158/1538-7445.AM2015-3698
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102236
ER

PT J
AU Quintanilla, I
   Wangsa, D
   Brown, M
   Ercilla, A
   Kius, G
   Vila, M
   Lozano, JJ
   Szallsi, Z
   Agell, N
   Castells, A
   Ried, T
   Camps, J
AF Quintanilla, Isabel
   Wangsa, Darawalee
   Brown, Markus
   Ercilla, Amaia
   Kius, Greg
   Vila, Maria
   Jose Lozano, Juan
   Szallsi, Zoltan
   Agell, Neus
   Castells, Antoni
   Ried, Thomas
   Camps, Jordi
TI Replication stress and DNA damage promote genomic instability in
   near-tetraploid colorectal cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Quintanilla, Isabel; Castells, Antoni; Camps, Jordi] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain.
   [Wangsa, Darawalee; Brown, Markus; Kius, Greg; Ried, Thomas] NCI, NIH, Bethesda, MD 20892 USA.
   [Ercilla, Amaia; Agell, Neus] Univ Barcelona, Barcelona, Spain.
   [Vila, Maria; Jose Lozano, Juan] CIBERehd, Bioinformat Platform, Barcelona, Spain.
   [Szallsi, Zoltan] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3031
DI 10.1158/1538-7445.AM2015-3031
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101080
ER

PT J
AU Railkar, R
   Li, QT
   Vourganti, S
   Brancato, SJ
   Choyke, PL
   Kobayashi, H
   Agarwal, PK
AF Railkar, Reema
   Li, Quentin
   Vourganti, Srinivas
   Brancato, Sam J.
   Choyke, Peter L.
   Kobayashi, Hisataka
   Agarwal, Piyush K.
TI Molecular targeted photoimmunotherapy as a treatment for bladder cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Railkar, Reema; Li, Quentin; Vourganti, Srinivas; Brancato, Sam J.; Choyke, Peter L.; Kobayashi, Hisataka; Agarwal, Piyush K.] NCI, NIH, Bethesda, MD 20892 USA.
RI Brancato, Sam/K-3266-2014
OI Brancato, Sam/0000-0002-3760-5818
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3311
DI 10.1158/1538-7445.AM2015-3311
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101340
ER

PT J
AU Rand, KA
   Song, C
   Dean, E
   Serie, D
   Curtin, K
   Hazelett, D
   Hwang, AE
   Sheng, X
   Stram, A
   Van Den Berg, DJ
   Huff, CA
   Bernal-Mizrachi, L
   Tomasson, MH
   Ailawadhi, S
   De Roos, A
   Singhal, S
   Pawlish, K
   Peters, E
   Bock, C
   Conti, DV
   Colditz, G
   Zimmerman, T
   Huntsman, S
   Graff, J
   Chanock, SJ
   Lieber, M
   Mehta, J
   Klein, EA
   Janakiraman, N
   Severson, RK
   Brooks-Wilson, AR
   Rajkumar, V
   Brown, EE
   Kolonel, L
   Slager, S
   Henderson, BE
   Giles, GG
   Spinelli, JJ
   Chiu, B
   Anderson, KC
   Zonder, J
   Orlowski, RZ
   Lonial, S
   Camp, N
   Vachon, C
   Ziv, E
   Stram, DO
   Haiman, CA
   Cozen, W
AF Rand, Kristin A.
   Song, Chi
   Dean, Eric
   Serie, Daniel
   Curtin, Karen
   Hazelett, Dennis
   Hwang, Arnie E.
   Sheng, Xin
   Stram, Alex
   Van Den Berg, David J.
   Huff, Carol Ann
   Bernal-Mizrachi, Leon
   Tomasson, Michael H.
   Ailawadhi, Sikander
   De Roos, Anneclaire
   Singhal, Seema
   Pawlish, Karen
   Peters, Edward
   Bock, Catherine
   Conti, David V.
   Colditz, Graham
   Zimmerman, Todd
   Huntsman, Scott
   Graff, John
   Chanock, Stephen J.
   Lieber, Michael
   Mehta, Jayesh
   Klein, Eric A.
   Janakiraman, Nalini
   Severson, Richard K.
   Brooks-Wilson, Angela R.
   Rajkumar, Vincent
   Brown, Elizabeth E.
   Kolonel, Laurence
   Slager, Susan
   Henderson, Brian E.
   Giles, Graham G.
   Spinelli, John J.
   Chiu, Brian
   Anderson, Kenneth C.
   Zonder, Jeffrey
   Orlowski, Robert Z.
   Lonial, Sagar
   Camp, Nicola
   Vachon, Celine
   Ziv, Elad
   Stram, Dan O.
   Haiman, Christopher A.
   Cozen, Wendy
CA African Ancestry Prostate Canc GWA
   African Ancestry Breast Canc GWAS
TI Multiple myeloma susceptibility loci examined in African and European
   ancestry populations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Rand, Kristin A.; Song, Chi; Hazelett, Dennis; Hwang, Arnie E.; Sheng, Xin; Stram, Alex; Van Den Berg, David J.; Conti, David V.; Lieber, Michael; Henderson, Brian E.; Stram, Dan O.; Haiman, Christopher A.; Cozen, Wendy] Keck Sch Med USC, Los Angeles, CA USA.
   [Rand, Kristin A.; Song, Chi; Hazelett, Dennis; Hwang, Arnie E.; Sheng, Xin; Stram, Alex; Van Den Berg, David J.; Conti, David V.; Lieber, Michael; Henderson, Brian E.; Stram, Dan O.; Haiman, Christopher A.; Cozen, Wendy] Norris Comprehens Canc Ctr, Los Angeles, CA USA.
   [Dean, Eric; Huntsman, Scott; Ziv, Elad] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Serie, Daniel; Ailawadhi, Sikander] Mayo Clin, Jacksonville, FL 32224 USA.
   [Curtin, Karen; Camp, Nicola] Univ Utah, Sch Med, Salt Lake City, UT USA.
   [Huff, Carol Ann] Johns Hopkins Sch Med, Baltimore, MD USA.
   [Bernal-Mizrachi, Leon; Lonial, Sagar] Emory Univ, Sch Med, Atlanta, GA USA.
   [Tomasson, Michael H.; Colditz, Graham] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO USA.
   [De Roos, Anneclaire] Drexel Univ, Philadelphia, PA 19104 USA.
   [Singhal, Seema; Mehta, Jayesh] Northwestern Univ, Robert H Lurie Canc Ctr, Chicago, IL 60611 USA.
   [Pawlish, Karen] New Jersey Dept Hlth, New Jersey State Canc Registry, Trenton, NJ USA.
   [Peters, Edward] Louisiana State Univ, Sch Publ Hlth, New Orleans, LA USA.
   [Bock, Catherine; Severson, Richard K.; Zonder, Jeffrey] Wayne State Univ Med, Karmanos Canc Inst, Detroit, MI USA.
   [Zimmerman, Todd; Chiu, Brian] Univ Chicago, Chicago, IL 60637 USA.
   [Graff, John] Rutgers State Univ, Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ 08903 USA.
   [Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Klein, Eric A.] Cleveland Clin, Cleveland, OH 44106 USA.
   [Janakiraman, Nalini] Henry Ford Hosp, Detroit, MI 48202 USA.
   [Brooks-Wilson, Angela R.] BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada.
   [Rajkumar, Vincent; Slager, Susan; Vachon, Celine] Mayo Clin, Rochester, MN USA.
   [Brown, Elizabeth E.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Kolonel, Laurence] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
   [Giles, Graham G.] Univ Melbourne, Canc Council Victoria, Melbourne, Vic, Australia.
   [Giles, Graham G.] Monash Univ, Melbourne, Vic 3004, Australia.
   [Spinelli, John J.] Univ British Columbia, Canc Control Res, Vancouver, BC V5Z 1M9, Canada.
   [Spinelli, John J.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada.
   [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Orlowski, Robert Z.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
RI Brooks-Wilson, Angela/E-9399-2012
OI Brooks-Wilson, Angela/0000-0003-1009-6408
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4629
DI 10.1158/1538-7445.AM2015-4629
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104257
ER

PT J
AU Reilly, KM
   Tuskan, RG
   Widemann, BC
AF Reilly, Karlyne M.
   Tuskan, Robert G.
   Widemann, Brigitte C.
TI Developing therapies for rare tumors: Using mouse models of malignant
   peripheral nerve sheath tumors to complement rare human samples in drug
   screens
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Reilly, Karlyne M.; Tuskan, Robert G.; Widemann, Brigitte C.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4199
DI 10.1158/1538-7445.AM2015-4199
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103284
ER

PT J
AU Reinhold, WC
   Sunshine, M
   Varma, S
   Rajapakse, V
   Doroshow, J
   Morris, J
   Pmmier, Y
AF Reinhold, William C.
   Sunshine, Margot
   Varma, Sudir
   Rajapakse, Vinodh
   Doroshow, James
   Morris, Joel
   Pmmier, Yves
TI Uses and update for CellMiner, a tool for access to and comparison of
   molecular data and pharmacological response for the NCI-60
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Reinhold, William C.; Sunshine, Margot; Varma, Sudir; Rajapakse, Vinodh; Doroshow, James; Morris, Joel; Pmmier, Yves] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3749
DI 10.1158/1538-7445.AM2015-3749
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102283
ER

PT J
AU Ren, NS
AF Ren, Natalie Shunxiang
TI The role of Sirt1 in tumorigenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ren, Natalie Shunxiang] NIEHS, NIH, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-167
DI 10.1158/1538-7445.AM2015-LB-167
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100267
ER

PT J
AU Rosenberg, PS
   Barker, KA
   Anderson, WF
AF Rosenberg, Philip S.
   Barker, Kimberly A.
   Anderson, William F.
TI Estrogen receptor status and the future burden of invasive and in-situ
   breast cancers in the United States
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Rosenberg, Philip S.; Barker, Kimberly A.; Anderson, William F.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3699
DI 10.1158/1538-7445.AM2015-3699
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102237
ER

PT J
AU Rota, CM
   Tschernia, N
   Feldman, S
   Mackall, C
   Lee, DW
AF Rota, Christopher M.
   Tschernia, Nicholas
   Feldman, Steven
   Mackall, Crystal
   Lee, Daniel W.
TI T cells engineered to express a chimeric antigen receptor targeting
   chondroitin sulfate proteoglycan 4 (CSPG4) specifically kill
   medulloblastoma and produce inflammatory cytokines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Rota, Christopher M.; Mackall, Crystal; Lee, Daniel W.] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.
   [Tschernia, Nicholas] Univ Nevada, Sch Med, Reno, NV 89557 USA.
   [Feldman, Steven] NCI, Surg Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3151
DI 10.1158/1538-7445.AM2015-3151
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101188
ER

PT J
AU Rothman, N
   Bassig, BA
   Cerhan, JR
   Au, WY
   Kim, HN
   Sangrajrang, S
   Hu, W
   Tse, J
   Berndt, S
   Zheng, TZ
   Zhang, HP
   Pornsopone, P
   Lee, JJ
   Kim, HJ
   Skibola, CF
   Vijai, J
   Burdette, L
   Yeager, M
   Brennan, P
   Shin, MH
   Liang, R
   Chanock, S
   Lan, Q
AF Rothman, Nathaniel
   Bassig, Bryan A.
   Cerhan, James R.
   Au, Wing-Yan
   Kim, Hee Nam
   Sangrajrang, Suleeporn
   Hu, Wei
   Tse, Jovic
   Berndt, Sonja
   Zheng, Tongzhang
   Zhang, Heping
   Pornsopone, Pattarapong
   Lee, Je-Jung
   Kim, Hyeoung-Joon
   Skibola, Christine F.
   Vijai, Joseph
   Burdette, Laurie
   Yeager, Meredith
   Brennan, Paul
   Shin, Min-Ho
   Liang, Raymond
   Chanock, Stephen
   Lan, Qing
TI Genetic susceptibility to diffuse large B-cell lymphoma in a pooled
   study of three Eastern Asian populations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Rothman, Nathaniel; Bassig, Bryan A.; Hu, Wei; Berndt, Sonja; Burdette, Laurie; Yeager, Meredith; Chanock, Stephen; Lan, Qing] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Cerhan, James R.] Mayo Clin, Rochester, MN USA.
   [Au, Wing-Yan; Tse, Jovic; Liang, Raymond] Univ Hong Kong, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China.
   [Kim, Hee Nam] Chonnam Natl Univ, Hwasun Hosp, Gwangju, South Korea.
   [Sangrajrang, Suleeporn; Pornsopone, Pattarapong] Natl Canc Inst, Bangkok, Thailand.
   [Zheng, Tongzhang; Zhang, Heping] Yale Univ, New Haven, CT 06520 USA.
   [Lee, Je-Jung; Kim, Hyeoung-Joon] Chonnam Natl Univ, Sch Med, Gwangju, South Korea.
   [Skibola, Christine F.] Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA.
   [Vijai, Joseph] Mem Sloan Kettering Canc Ctr, New York, NY USA.
   [Brennan, Paul] Int Agcy Res Canc, Paris, France.
   [Shin, Min-Ho] Chonnam Natl Univ, Gwangju, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4626
DI 10.1158/1538-7445.AM2015-4626
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104254
ER

PT J
AU Sato, K
   Nagaya, T
   Choyke, PL
   Kobayashi, H
AF Sato, Kazuhide
   Nagaya, Tadanobu
   Choyke, Peter L.
   Kobayashi, Hisataka
TI Near infrared photoimmunotherapy for lung metastases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sato, Kazuhide; Nagaya, Tadanobu; Choyke, Peter L.; Kobayashi, Hisataka] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4118
DI 10.1158/1538-7445.AM2015-4118
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103207
ER

PT J
AU Seabloom, D
   Galbraith, A
   Wuertz, B
   Haynes, A
   Miller, MS
   Steele, V
   Wattenberg, L
   Ondrey, FG
AF Seabloom, Donna
   Galbraith, Art
   Wuertz, Beverly
   Haynes, Anna
   Miller, Mark S.
   Steele, Vernon
   Wattenberg, Lee
   Ondrey, Frank G.
TI Effects of dietary metformin/pioglitazone on lung adenoma formation in
   A/J mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Seabloom, Donna; Galbraith, Art; Wuertz, Beverly; Haynes, Anna; Wattenberg, Lee; Ondrey, Frank G.] Univ Minnesota, Minneapolis, MN USA.
   [Miller, Mark S.; Steele, Vernon] NCI, Div Canc Prevent, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-264
DI 10.1158/1538-7445.AM2015-LB-264
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100357
ER

PT J
AU Sheldon, KL
   Sackett, DL
AF Sheldon, Kely L.
   Sackett, Dan L.
TI The ability of tubulin to close mitochondrial VDAC pores depends on beta
   tubulin isotype
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sheldon, Kely L.; Sackett, Dan L.] NICHD, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3044
DI 10.1158/1538-7445.AM2015-3044
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101092
ER

PT J
AU Shoemaker, RH
   Lovell, MW
   Whalen, JJ
   Moeinpour, F
   Grubbs, CJ
AF Shoemaker, Robert H.
   Lovell, Michael W.
   Whalen, John J.
   Moeinpour, Fariba
   Grubbs, Clinton J.
TI Targeting STAT3 for mammary cancer prevention in MMTV/Neu mice employing
   the antagonist GLG-302
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Shoemaker, Robert H.] NCI, Bethesda, MD 20892 USA.
   [Lovell, Michael W.; Whalen, John J.] GLG Pharma LLC, Jupiter, FL USA.
   [Moeinpour, Fariba; Grubbs, Clinton J.] Univ Alabama Birmingham, Birmingham, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4657
DI 10.1158/1538-7445.AM2015-4657
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104285
ER

PT J
AU Shukla, A
   Bai, L
   Yang, H
   Doran, A
   Hu, Y
   Geiger, T
   Lee, M
   Keane, T
   Hunter, KW
AF Shukla, Anjali
   Bai, Ling
   Yang, Howard
   Doran, Anthony
   Hu, Ying
   Geiger, Thomas
   Lee, Maxwell
   Keane, Thomas
   Hunter, Kent W.
TI Integrating SNPs, epigenetics and transcriptomics to better understand
   the inherited predisposition to breast cancer metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Shukla, Anjali; Bai, Ling; Yang, Howard; Hu, Ying; Geiger, Thomas; Lee, Maxwell; Hunter, Kent W.] NCI, Bethesda, MD 20892 USA.
   [Doran, Anthony; Keane, Thomas] Welcome Trust Sanger Ctr, Hinxton, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4138
DI 10.1158/1538-7445.AM2015-4138
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103226
ER

PT J
AU Skaer, CW
   Pan, P
   Young, M
   Wang, HT
   Oshima, K
   Huang, YW
   Stoner, GD
   Lechner, J
   Wang, LS
AF Skaer, Chad W.
   Pan, Pan
   Young, Matthew
   Wang, Hsin Tzu
   Oshima, Kiyoko
   Huang, Yi-Wen
   Stoner, Gary D.
   Lechner, John
   Wang, Li-Shu
TI Effects of black raspberry diet on the metabolomic profile of C57BL/6J
   mouse tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Skaer, Chad W.; Pan, Pan; Wang, Hsin Tzu; Oshima, Kiyoko; Huang, Yi-Wen; Stoner, Gary D.; Lechner, John; Wang, Li-Shu] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Young, Matthew] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-263
DI 10.1158/1538-7445.AM2015-LB-263
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100356
ER

PT J
AU Stephen, AG
   Gillette, WK
   Grose, C
   Esposito, D
AF Stephen, Andrew G.
   Gillette, William K.
   Grose, Carissa
   Esposito, Dominic
TI Production and biochemical characterization of farnesylated and
   methylated KRAS4b using engineered baculovirus
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Stephen, Andrew G.; Gillette, William K.; Grose, Carissa; Esposito, Dominic] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3925
DI 10.1158/1538-7445.AM2015-3925
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103022
ER

PT J
AU Stephens, SH
   Fleming, PJ
   Mitchell, BD
   Ambulos, N
   Bailey-Wilson, JE
   Chang, C
   Feliciano, JL
   Sausville, EA
   Edelman, MJ
AF Stephens, Sarah H.
   Fleming, Patrice J.
   Mitchell, Braxton D.
   Ambulos, Nicholas
   Bailey-Wilson, Joan E.
   Chang, Christy
   Feliciano, Josephine L.
   Sausville, Edward A.
   Edelman, Martin J.
TI Somatic mutation profile differences of "driver" mutations in 26
   oncogenic lung cancer genes between African American and European
   American non-small cell lung cancer patients
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Stephens, Sarah H.; Fleming, Patrice J.; Mitchell, Braxton D.; Ambulos, Nicholas; Chang, Christy; Feliciano, Josephine L.; Sausville, Edward A.; Edelman, Martin J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Bailey-Wilson, Joan E.] NHGRI, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4599
DI 10.1158/1538-7445.AM2015-4599
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104227
ER

PT J
AU Stockwin, LH
   Mullendore, M
   Bonomi, C
   Dougherty, K
   Doroshaw, JH
   Hollingshead, MG
   Newton, DL
AF Stockwin, Luke H.
   Mullendore, Michael
   Bonomi, Carrie
   Dougherty, Kelly
   Doroshaw, James H.
   Hollingshead, Melinda G.
   Newton, Dianne L.
TI Cell sorting strategies for the isolation of cancer cells and associated
   fibroblasts from tumor biopsies, surgical resections, and
   patient-derived xenografts
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Stockwin, Luke H.; Mullendore, Michael; Bonomi, Carrie; Dougherty, Kelly; Newton, Dianne L.] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Frederick, MD USA.
   [Doroshaw, James H.] NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
   [Hollingshead, Melinda G.] NCI, Biol Testing Branch, Dev Therapeut Program, Frederick, MD 21701 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5139
DI 10.1158/1538-7445.AM2015-5139
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105317
ER

PT J
AU Su, WH
   Chiu, CC
   Shugart, YY
AF Su, Wen-Hui
   Chiu, Chi-Cking
   Shugart, Yin Yao
TI Heterogeneity revealed through meta-analysis might link geographical
   differences with nasopharyngeal carcinoma incidence in Han Chinese
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Su, Wen-Hui; Chiu, Chi-Cking] Chang Gung Univ, Taoyuan, Taiwan.
   [Shugart, Yin Yao] NIMH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4630
DI 10.1158/1538-7445.AM2015-4630
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104258
ER

PT J
AU Sun, WY
   Chatterjee, B
   Wang, YH
   Stevenson, HS
   Edelman, DC
   Meltzer, PS
   Barr, FG
AF Sun, Wenyue
   Chatterjee, Bishwanath
   Wang, Yonghong
   Stevenson, Holly S.
   Edelman, Daniel C.
   Meltzer, Paul S.
   Barr, Frederic G.
TI Distinct methylation profiles characterize fusion-positive and
   fusion-negative rhabdomyosarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sun, Wenyue; Chatterjee, Bishwanath; Barr, Frederic G.] NCI, Canc Mol Pathol Sect, Pathol Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Wang, Yonghong; Stevenson, Holly S.; Edelman, Daniel C.; Meltzer, Paul S.] NCI, Clin Mol Profiling Core, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3278
DI 10.1158/1538-7445.AM2015-3278
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101307
ER

PT J
AU Sung, H
   Chang-Claude, J
   Figueroa, J
   Nevanlinna, H
   Giles, GG
   Cox, A
   Cross, SS
   Southey, MC
   McLean, C
   Bolla, MK
   Shah, M
   Dunning, AM
   Dennis, J
   Wang, Q
   Michailidou, K
   Easton, DF
   Pharoah, PDP
   Sherman, ME
   Garcia-Closas, M
   Yang, XHR
AF Sung, Hyuna
   Chang-Claude, Jenny
   Figueroa, Jonine
   Nevanlinna, Heli
   Giles, Graham G.
   Cox, Angelia
   Cross, Simon S.
   Southey, Melissa C.
   McLean, Catriona
   Bolla, Manjeet K.
   Shah, Mitul
   Dunning, Alison M.
   Dennis, Joe
   Wang, Qin
   Michailidou, Kyriaki
   Easton, Douglas F.
   Pharoah, Paul D. P.
   Sherman, Mark E.
   Garcia-Closas, Montserrat
   Yang, Xiaohong R.
TI Heterogeneity of luminal breast cancer characterized by
   immunohistochemical expression of basal markers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sung, Hyuna; Figueroa, Jonine; Sherman, Mark E.; Yang, Xiaohong R.] NCI, Rockville, MD USA.
   [Chang-Claude, Jenny] German Canc Res Ctr, Heidelberg, Germany.
   [Nevanlinna, Heli] Univ Helsinki, Helsinki, Finland.
   [Nevanlinna, Heli] Univ Helsinki, Cent Hosp, Helsinki, Finland.
   [Giles, Graham G.] Canc Epidemiol Centrer, Melbourne, Vic, Australia.
   [Cox, Angelia; Cross, Simon S.] Univ Sheffield, Sheffield Canc Res Ctr, Sheffield, S Yorkshire, England.
   [Southey, Melissa C.] Univ Melbourne, Melbourne, Vic, Australia.
   [McLean, Catriona] Alfred Hosp, Malbourne, Australia.
   [Bolla, Manjeet K.; Shah, Mitul; Dunning, Alison M.; Dennis, Joe; Wang, Qin; Michailidou, Kyriaki; Easton, Douglas F.; Pharoah, Paul D. P.] Univ Cambridge, Cambridge, England.
   [Garcia-Closas, Montserrat] Inst Canc Res, London SW3 6JB, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5570
DI 10.1158/1538-7445.AM2015-5570
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106229
ER

PT J
AU Sung, H
   Yang, HH
   Zhang, H
   Yang, Q
   Hu, N
   Tang, ZZ
   Su, H
   Wang, LM
   Wang, CY
   Ding, T
   Fan, JH
   Qiao, YL
   Wheeler, W
   Giffen, C
   Burdett, L
   Wang, ZM
   Lee, MP
   Chanock, SJ
   Dawsey, SM
   Freedman, ND
   Abnet, CC
   Goldstein, AM
   Yu, K
   Taylor, PR
   Hyland, PL
AF Sung, Hyuna
   Yang, Howard H.
   Zhang, Han
   Yang, Qi
   Hu, Nan
   Tang, Ze-Zhong
   Su, Hua
   Wang, Lemin
   Wang, Chaoyu
   Ding, Ti
   Fan, Jin-Hu
   Qiao, You-Lin
   Wheeler, William
   Giffen, Carol
   Burdett, Laurie
   Wang, Zhaoming
   Lee, Maxwell P.
   Chanock, Stephen J.
   Dawsey, Sanford M.
   Freedman, Neal D.
   Abnet, Christian C.
   Goldstein, Alisa M.
   Yu, Kai
   Taylor, Philip R.
   Hyland, Paula L.
TI Common genetic variants in epigenetic machinery genes and risk of upper
   gastrointestinal cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sung, Hyuna; Yang, Howard H.; Zhang, Han; Yang, Qi; Hu, Nan; Su, Hua; Wang, Lemin; Wang, Chaoyu; Burdett, Laurie; Wang, Zhaoming; Lee, Maxwell P.; Chanock, Stephen J.; Dawsey, Sanford M.; Freedman, Neal D.; Abnet, Christian C.; Goldstein, Alisa M.; Yu, Kai; Taylor, Philip R.; Hyland, Paula L.] NCI DCEG, Bethesda, MD USA.
   [Tang, Ze-Zhong; Ding, Ti] Shanxi Canc Hosp, Taiyuan, Peoples R China.
   [Fan, Jin-Hu; Qiao, You-Lin] Chinese Acad Med Sci, Dept Epidemiol, Canc Inst Hosp, Beijing 100730, Peoples R China.
   [Wheeler, William; Giffen, Carol] Informat Management Serv Inc, Silver Spring, MD USA.
RI Qiao, You-Lin/B-4139-2012
OI Qiao, You-Lin/0000-0001-6380-0871
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4622
DI 10.1158/1538-7445.AM2015-4622
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104250
ER

PT J
AU Suryani, S
   Evans, K
   Richmond, J
   Robbins, A
   Bracken, L
   Kurmasheva, R
   Houghton, PJ
   Smith, MA
   Lock, RB
AF Suryani, Santi
   Evans, Kathryn
   Richmond, Jennifer
   Robbins, Alissa
   Bracken, Lauryn
   Kurmasheva, Raushan
   Houghton, Peter J.
   Smith, Malcolm A.
   Lock, Richard B.
TI Evaluation of the Bcl-2 inhibitor ABT-199 in xenograft models of acute
   lymphoblastic leukemia by the pediatric preclinical testing program
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Suryani, Santi; Evans, Kathryn; Richmond, Jennifer; Robbins, Alissa; Bracken, Lauryn; Lock, Richard B.] Childrens Canc Inst, Leukaemia Biol, Sydney, NSW, Australia.
   [Kurmasheva, Raushan; Houghton, Peter J.] Nationwide Childrens Hosp, Ctr Childhood Canc, Columbus, OH 43205 USA.
   [Smith, Malcolm A.] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3276
DI 10.1158/1538-7445.AM2015-3276
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101305
ER

PT J
AU Terabe, M
   Robertson, F
   Kato, S
   De Ravin, E
   Clark, K
   Mizra, AM
   Berzofsky, JA
AF Terabe, Masaki
   Robertson, Faith
   Kato, Shingo
   De Ravin, Emma
   Clark, Katharine
   Mizra, Amer M.
   Berzofsky, Jay A.
TI Blockade of TGF-beta1 and 2 without TGF-beta3 blockade is sufficient to
   facilitate tumor vaccine efficacy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Terabe, Masaki; Robertson, Faith; Kato, Shingo; De Ravin, Emma; Clark, Katharine; Berzofsky, Jay A.] NCI, NIH, Bethesda, MD 20892 USA.
   [Mizra, Amer M.] Xoma Corp, Berkeley, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-233
DI 10.1158/1538-7445.AM2015-LB-233
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100328
ER

PT J
AU Tingle, S
   Carrick, D
   Schully, S
   Clyne, M
   Nelson, SA
AF Tingle, Sharna
   Carrick, Danielle
   Schully, Sheri
   Clyne, Mindy
   Nelson, Stefanie A.
TI Tracking the functional analysis of cancer risk variants
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Tingle, Sharna; Carrick, Danielle; Schully, Sheri; Nelson, Stefanie A.] NCI, Rockville, MD USA.
   [Clyne, Mindy] Kelly Serv, Troy, MI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5572
DI 10.1158/1538-7445.AM2015-5572
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106231
ER

PT J
AU Toledo, DM
   Pinney, SM
   Mandal, D
   de Andrade, M
   Kupert, E
   Franks, J
   Gaba, C
   Simpson, CL
   You, M
   Anderson, MW
   Bailey-Wilson, JE
   Amos, CI
   Schwartz, A
AF Toledo, Diana M.
   Pinney, Susan M.
   Mandal, Diptasri
   de Andrade, Mariza
   Kupert, Elena
   Franks, Jennifer
   Gaba, Colette
   Simpson, Claire L.
   You, Ming
   Anderson, Marshall W.
   Bailey-Wilson, Joan E.
   Amos, Christopher I.
   Schwartz, Ann
TI Genetic Epidemiology of Lung Cancer Consortium: genome-wide association
   study of familial lung cancer cases
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Toledo, Diana M.; Franks, Jennifer; Simpson, Claire L.; Amos, Christopher I.] Dartmouth Coll, Hanover, NH 03755 USA.
   [Pinney, Susan M.; Kupert, Elena; Anderson, Marshall W.] Univ Cincinnati, Cincinnati, OH USA.
   [Mandal, Diptasri] LSU Med Sch, New Orleans, LA USA.
   [de Andrade, Mariza] Mayo Clin, Rochester, MN USA.
   [Gaba, Colette] Univ Toledo, Toledo, OH 43606 USA.
   [You, Ming] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Bailey-Wilson, Joan E.] NHGRI, Baltimore, MD USA.
   [Schwartz, Ann] Karmanos Canc Ctr, Detroit, MI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-189
DI 10.1158/1538-7445.AM2015-LB-189
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100288
ER

PT J
AU Uygur, B
   Leikina, E
   Chernomordik, LV
AF Uygur, Berna
   Leikina, Evgenia
   Chernomordik, Leonid V.
TI Interactions between co-cultured myoblasts and prostate cancer cells
   kill myoblasts but promote cancer cell proliferation and fusion:
   implications for cachexia and metastasis to skeletal muscle
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Uygur, Berna; Leikina, Evgenia; Chernomordik, Leonid V.] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4030
DI 10.1158/1538-7445.AM2015-4030
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103123
ER

PT J
AU Varticoyski, L
   Kim, S
   Nickerson, ML
   Thompson, B
   Lao, QZ
   Grontved, L
   Baek, S
   Sung, MH
   Theodorescu, D
   Dean, M
   Hager, GL
AF Varticoyski, Lyuba
   Kim, Sohyoung
   Nickerson, Michael L.
   Thompson, Bethtrice
   Lao, Qizong
   Grontved, Lars
   Baek, Songjoon
   Sung, Myong-Hee
   Theodorescu, Dan
   Dean, Michael
   Hager, Gordon L.
TI Novel molecular markers of bladder cancer progression identified by
   global chromatin profiling
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Varticoyski, Lyuba; Kim, Sohyoung; Nickerson, Michael L.; Lao, Qizong; Baek, Songjoon; Sung, Myong-Hee; Hager, Gordon L.] NCI, CCR, Bethesda, MD 20892 USA.
   [Thompson, Bethtrice] Clark Atlanta Univ, Atlanta, GA 30314 USA.
   [Grontved, Lars] Univ Southern Denmark, Odense M, Denmark.
   [Theodorescu, Dan] Univ Colorado, Denver, CO 80202 USA.
   [Dean, Michael] NCI, CCR, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4783
DI 10.1158/1538-7445.AM2015-4783
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104409
ER

PT J
AU Violet, PC
   Parrow, NL
   Oscar, SL
   Yang, J
   Levine, MA
AF Violet, Pierre-Christian
   Parrow, Nermi L.
   Oscar, Serrano L.
   Yang, Jacqueline
   Levine, Mark A.
TI Pharmaceutical effect of vitamin C (ascorbate) on B16 melanoma in vitro
   and in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Violet, Pierre-Christian; Parrow, Nermi L.; Oscar, Serrano L.; Yang, Jacqueline; Levine, Mark A.] NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5134
DI 10.1158/1538-7445.AM2015-5134
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105312
ER

PT J
AU Vodnala, SK
AF Vodnala, Suman K.
TI MicroRNA-mediated reprogramming of myeloid cells by targeting TGF beta
   signaling and its associated molecular network
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Vodnala, Suman K.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3128
DI 10.1158/1538-7445.AM2015-3128
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101171
ER

PT J
AU Wahba, A
   Rath, BH
   Camphausen, K
   Tofilon, PJ
AF Wahba, Amy
   Rath, Barbara H.
   Camphausen, Kevin
   Tofilon, Philip J.
TI Radiation-induced translational control of gene expression in
   glioblastoma stem-like cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wahba, Amy; Rath, Barbara H.; Camphausen, Kevin; Tofilon, Philip J.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3332
DI 10.1158/1538-7445.AM2015-3332
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101361
ER

PT J
AU Walia, V
   Prickett, T
   Kim, JS
   Gartner, JJ
   Lin, JC
   Rosenberg, SA
   Elble, RC
   Solomon, DA
   Waldman, T
   Samuels, Y
AF Walia, Vijay
   Prickett, Todd
   Kim, Jung-Sik
   Gartner, Jared J.
   Lin, Jimmy C.
   Rosenberg, Steven A.
   Elble, Randolph C.
   Solomon, David A.
   Waldman, Todd
   Samuels, Yardena
TI Mutational and functional analysis of the tumor suppressor PTPRD in
   human melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Walia, Vijay; Prickett, Todd; Gartner, Jared J.; Lin, Jimmy C.] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Kim, Jung-Sik; Solomon, David A.; Waldman, Todd] Georgetown Univ, Sch Med, Lombardi Canc Ctr, Washington, DC USA.
   [Rosenberg, Steven A.] NCI, Surg Branch, Bethesda, MD 20892 USA.
   [Elble, Randolph C.] So Illinois Univ, Springfield, IL USA.
   [Samuels, Yardena] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-065
DI 10.1158/1538-7445.AM2015-LB-065
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100169
ER

PT J
AU Walker, AJ
   Zhang, L
   Long, AH
   Orentas, RJ
   Mackall, CL
AF Walker, Alec J.
   Zhang, Ling
   Long, Adrienne H.
   Orentas, Rimas J.
   Mackall, Crystal L.
TI Antigen-induced downmodulation is associated with diminished efficacy of
   a novel chimeric antigen receptor targeting anaplastic lymphoma kinase
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Walker, Alec J.; Zhang, Ling; Long, Adrienne H.; Orentas, Rimas J.; Mackall, Crystal L.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3140
DI 10.1158/1538-7445.AM2015-3140
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101180
ER

PT J
AU Walsh, N
   Alberts, DS
   Brown, P
   Limburg, P
   Sherman, M
   Szabo, E
AF Walsh, Naomi
   Alberts, David S.
   Brown, Powel
   Limburg, Paul
   Sherman, Mark
   Szabo, Eva
TI Framework for clinical evaluation of chemopreventive agents: Defining
   criteria for future assessment
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Walsh, Naomi; Sherman, Mark; Szabo, Eva] NCI, Rockville, MD USA.
   [Alberts, David S.] Univ Arizona, Ctr Canc, Arizona, AZ USA.
   [Brown, Powel] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Limburg, Paul] Mayo Clin, Ctr Canc, Rochester, MN USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4662
DI 10.1158/1538-7445.AM2015-4662
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104290
ER

PT J
AU Walters, IB
   Bender, LH
   Terabe, M
   Berzofsky, JA
AF Walters, Ian B.
   Bender, Lewis H.
   Terabe, Masaki
   Berzofsky, Jay A.
TI INT230-6, a novel intratumoral anticancer agent, is able to eradicate
   large established tumors and stimulate potent anti tumor immunity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Walters, Ian B.; Bender, Lewis H.] Intens Therapeut, Westport, CT USA.
   [Terabe, Masaki; Berzofsky, Jay A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4295
DI 10.1158/1538-7445.AM2015-4295
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103379
ER

PT J
AU Wang, C
   Frankowski, K
   Yaroslav, T
   Patnaik, S
   Schoenen, F
   Southall, N
   Sun, W
   Titus, S
   Griner, L
   Dextras, C
   Sultan, J
   Kandela, I
   Lewandowska, M
   Wen, YP
   Norton, J
   Kang, JS
   Mazar, A
   Zhang, W
   Aube, J
   Ferrer, M
   Rudloff, U
   Marugan, JJ
   Huang, S
AF Wang, Chen
   Frankowski, Kevin
   Yaroslav, Teper
   Patnaik, Samarjit
   Schoenen, Frank
   Southall, Noel
   Sun, Wei
   Titus, Steve
   Griner, Lesley
   Dextras, Christopher
   Sultan, Jamey
   Kandela, Irawati
   Lewandowska, Marzena
   Wen, Yi-Ping
   Norton, John
   Kang, Jin Sol
   Mazar, Andrew
   Zhang, Wei
   Aube, Jeffrey
   Ferrer, Marc
   Rudloff, Udo
   Marugan, Juan Jose
   Huang, Sui
TI Metarrestin effectively disassembles PNCs and inhibits metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wang, Chen; Lewandowska, Marzena; Wen, Yi-Ping; Norton, John; Huang, Sui] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Frankowski, Kevin; Schoenen, Frank; Aube, Jeffrey] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66045 USA.
   [Yaroslav, Teper; Rudloff, Udo] NCI, Thorac & GI Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Patnaik, Samarjit; Southall, Noel; Sun, Wei; Titus, Steve; Griner, Lesley; Dextras, Christopher; Sultan, Jamey; Zhang, Wei; Ferrer, Marc; Marugan, Juan Jose] NIH, Natl Ctr Adv Translat Sci, Rockville, MD USA.
   [Kandela, Irawati; Kang, Jin Sol; Mazar, Andrew] Northwestern Univ, Evanston, IL USA.
RI Lewandowska, Marzena/F-6757-2015
OI Lewandowska, Marzena/0000-0002-7360-7810
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5368
DI 10.1158/1538-7445.AM2015-5368
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106029
ER

PT J
AU Wang, YJ
   Anreddy, N
   Patel, BA
   Chufan, EE
   Singh, S
   Zhang, GN
   Zhang, YK
   Barbuti, AM
   Ambudkar, SV
   Talele, TT
   Chen, ZS
AF Wang, Yi-Jun
   Anreddy, Nagaraju
   Patel, Bhargav A.
   Chufan, Eduardo E.
   Singh, Satyakam
   Zhang, Guan-Nan
   Zhang, Yun-Kai
   Barbuti, Anna Maria
   Ambudkar, Suresh V.
   Talele, Tanaji T.
   Chen, Zhe-Sheng
TI TTT-28, a newly synthesized thiazole-valine peptide, antagonizes
   multidrug resistance by inhibiting the efflux activity of the ABCB1
   transporter
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wang, Yi-Jun; Anreddy, Nagaraju; Patel, Bhargav A.; Singh, Satyakam; Zhang, Guan-Nan; Zhang, Yun-Kai; Barbuti, Anna Maria; Ambudkar, Suresh V.; Talele, Tanaji T.; Chen, Zhe-Sheng] St Johns Univ, Queens, NY USA.
   [Chufan, Eduardo E.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4422
DI 10.1158/1538-7445.AM2015-4422
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104053
ER

PT J
AU Waterfall, J
   Killian, JK
   Zhu, YJ
   Lau, CC
   Miettinen, M
   Heiman, LJ
   Meltzer, PS
AF Waterfall, Joshua
   Killian, J. Keith
   Zhu, Yuelin Jack
   Lau, C. Christopher
   Miettinen, Markku
   Heiman, Lee J.
   Meltzer, Paul S.
TI Collaborating mutations in gastrointestinal stromal tumor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Waterfall, Joshua; Killian, J. Keith; Zhu, Yuelin Jack; Lau, C. Christopher; Miettinen, Markku; Heiman, Lee J.; Meltzer, Paul S.] NCI, NIH, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-171
DI 10.1158/1538-7445.AM2015-LB-171
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100271
ER

PT J
AU Wei, QY
   Liu, HL
   Liu, ZS
   Amos, CI
   Doherty, JA
   Bickeboller, H
   Hung, RJ
   Brennan, P
   Houlston, R
   Landi, MT
   Caporaso, NE
   Christiani, D
AF Wei, Qingyi
   Liu, Hongliang
   Liu, Zhensheng
   Amos, Christopher I.
   Doherty, Jennifer A.
   Bickeboller, Heike
   Hung, Rayjean J.
   Brennan, Paul
   Houlston, Richard
   Landi, Maria Teresa
   Caporaso, Neil E.
   Christiani, David
TI A novel variant in DNA repair gene GTF2H4 is associated with lung cancer
   risk: A reanalysis of GWAS datasets from the TRICL consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wei, Qingyi; Liu, Hongliang; Liu, Zhensheng] Duke Canc Inst, Durham, NC USA.
   [Amos, Christopher I.; Doherty, Jennifer A.] Norris Cotton Canc Ctr, Lebanon, NH USA.
   [Bickeboller, Heike] Univ Gottingen, Humboldtallee, Germany.
   [Hung, Rayjean J.] Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.
   [Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
   [Houlston, Richard] Inst Canc Res, Sutton, Surrey, England.
   [Landi, Maria Teresa; Caporaso, Neil E.] NCI, Bethesda, MD 20892 USA.
   [Christiani, David] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
OI Houlston, Richard/0000-0002-5268-0242
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4597
DI 10.1158/1538-7445.AM2015-4597
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104225
ER

PT J
AU Weyemi, SU
   Redon, CE
   Choudhuri, R
   Maeda, D
   Kasoji, M
   Abrams, N
   Bonner, WM
AF Weyemi, Sossou U.
   Redon, Christophe E.
   Choudhuri, Rohini
   Maeda, Daisuke
   Kasoji, Manjula
   Abrams, Natalie
   Bonner, William M.
TI Histone H2AX is a novel regulator of epithelial to mesenchymal
   transition
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Weyemi, Sossou U.; Redon, Christophe E.; Choudhuri, Rohini; Maeda, Daisuke; Kasoji, Manjula; Abrams, Natalie; Bonner, William M.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4774
DI 10.1158/1538-7445.AM2015-4774
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104401
ER

PT J
AU Winchester, DA
   Till, C
   Goodman, PJ
   Tangen, CM
   Santella, RM
   Johnson-Pais, TL
   Leach, RJ
   Xu, JF
   Zheng, SL
   Thompson, IM
   Lucia, MS
   Lippmann, SM
   Parnes, HL
   Dluzniewski, PJ
   Isaacs, WB
   De Marzo, AM
   Drake, CG
   Platz, EA
AF Winchester, Danyelle A.
   Till, Cathee
   Goodman, Phyllis J.
   Tangen, Catherine M.
   Santella, Regina M.
   Johnson-Pais, Teresa L.
   Leach, Robin J.
   Xu, Jianfeng
   Zheng, S. Lilly
   Thompson, Ian M.
   Lucia, M. Scott
   Lippmann, Scott M.
   Parnes, Howard L.
   Dluzniewski, Paul J.
   Isaacs, William B.
   De Marzo, Angelo M.
   Drake, Charles G.
   Platz, Elizabeth A.
TI Variation in genes involved in the immune response and prostate cancer
   risk in the placebo arm of the Prostate Cancer Prevention Trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Winchester, Danyelle A.; Dluzniewski, Paul J.; Platz, Elizabeth A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Till, Cathee; Goodman, Phyllis J.; Tangen, Catherine M.] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98104 USA.
   [Santella, Regina M.] Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA.
   [Johnson-Pais, Teresa L.; Leach, Robin J.; Thompson, Ian M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA.
   [Xu, Jianfeng] NorthShore Univ Hlth Syst, Program Personalized Canc Care, Evanston, IL USA.
   [Xu, Jianfeng] NorthShore Univ Hlth Syst, Dept Surg, Evanston, IL USA.
   [Zheng, S. Lilly] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA.
   [Lucia, M. Scott] Univ Colorado, Dept Pathol, Aurora, CO USA.
   [Lippmann, Scott M.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
   [Parnes, Howard L.] NCI, Prostate & Urol Canc Res Grp, Canc Prevent Div, NIH,Dept Hlth & Human Serv, Rockville, MD USA.
   [Isaacs, William B.; De Marzo, Angelo M.; Drake, Charles G.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4605
DI 10.1158/1538-7445.AM2015-4605
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104233
ER

PT J
AU Xiao, CL
   Yaschenko, E
   Sherry, S
AF Xiao, Chunlin
   Yaschenko, Eugene
   Sherry, Stephen
TI Cloud-based variant analysis solution using control-accessed sequencing
   data
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Xiao, Chunlin; Yaschenko, Eugene; Sherry, Stephen] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4858
DI 10.1158/1538-7445.AM2015-4858
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597105043
ER

PT J
AU Yamade, M
   Pommier, Y
   Kohn, KW
AF Yamade, Mihoko
   Pommier, Yves
   Kohn, Kurt W.
TI LIX1L, an EMT-correlated gene that behaves as if it inhibits the EMT
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yamade, Mihoko; Pommier, Yves; Kohn, Kurt W.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4104
DI 10.1158/1538-7445.AM2015-4104
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103193
ER

PT J
AU Yan, HHY
   Pang, YL
   Hunter, K
   Khanna, C
   Yang, L
AF Yan, Hannah H. Y.
   Pang, Yanli
   Hunter, Kent
   Khanna, Chand
   Yang, Li
TI CCL9 induction in myeloid cells of the premetastatic niche enhances
   tumor cell survival and metastatic colonization
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yan, Hannah H. Y.; Pang, Yanli; Hunter, Kent; Khanna, Chand; Yang, Li] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3172
DI 10.1158/1538-7445.AM2015-3172
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101207
ER

PT J
AU Yang, CZ
   Wang, HR
   Pacak, K
   Zhuang, ZP
AF Yang, Chunzhang
   Wang, Herui
   Pacak, Karel
   Zhuang, Zhengping
TI Genetic abnormalites in hypoxia sensing regulators cause human
   pheochromocytoma/paraganglioma and plolycythemia syndrome
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Chunzhang; Wang, Herui; Zhuang, Zhengping] NINDS, Bethesda, MD 20892 USA.
   [Pacak, Karel] NICHD, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3943
DI 10.1158/1538-7445.AM2015-3943
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103040
ER

PT J
AU Yang, HP
   Anderson, WF
   Trabert, B
   Rosenberg, PS
   Gierach, GL
   Bodelon, C
   Wentzensen, N
   Cronin, KA
   Sherman, ME
AF Yang, Hannah P.
   Anderson, William F.
   Trabert, Britton
   Rosenberg, Philip S.
   Gierach, Gretchen L.
   Bodelon, Clara
   Wentzensen, Nicolas
   Cronin, Kathleen A.
   Sherman, Mark E.
TI Incidence trends of breast, endometrial, and ovarian cancer among US
   women in relation to changing patterns of menopausal hormone therapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Hannah P.; Anderson, William F.; Trabert, Britton; Rosenberg, Philip S.; Gierach, Gretchen L.; Bodelon, Clara; Wentzensen, Nicolas; Cronin, Kathleen A.; Sherman, Mark E.] NCI, Bethesda, MD 20892 USA.
RI Gierach, Gretchen/E-1817-2016
OI Gierach, Gretchen/0000-0002-0165-5522
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3700
DI 10.1158/1538-7445.AM2015-3700
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597102238
ER

PT J
AU Yang, YA
   Flanders, KC
   Tang, BW
   Anver, MR
   Merchant, A
   Yang, H
   Lee, M
   Lonning, S
   McPherson, JM
   Wakefield, LM
AF Yang, Yu-an
   Flanders, Kathleen C.
   Tang, Binwu
   Anver, Miriam R.
   Merchant, Anand
   Yang, Howard
   Lee, Maxwell
   Lonning, Scott
   McPherson, John M.
   Wakefield, Lalage M.
TI Neutralizing anti-TGF-beta antibodies elicit heterogeneous therapeutic
   responses in a panel of murine metastatic breast cancer models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Yu-an; Flanders, Kathleen C.; Tang, Binwu; Anver, Miriam R.; Merchant, Anand; Yang, Howard; Lee, Maxwell; Wakefield, Lalage M.] NCI, Bethesda, MD 20892 USA.
   [Lonning, Scott; McPherson, John M.] Genzyme Corp, Framingham, MA 01701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4094
DI 10.1158/1538-7445.AM2015-4094
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597103183
ER

PT J
AU Yokoyama, T
   Gordon, N
   Yu, MS
   Kohn, EC
   Lee, JM
AF Yokoyama, Takuhei
   Gordon, Nicolas
   Yu, Minshu
   Kohn, Elise C.
   Lee, Jung-Min
TI Navitoclax (Nav) and BMN 673 yield cytotoxicity with lower doses than
   used for single agents in high-grade serous ovarian cancer (HGSOC)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yokoyama, Takuhei; Gordon, Nicolas; Yu, Minshu; Kohn, Elise C.; Lee, Jung-Min] NIH, Bldg 10, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 5363
DI 10.1158/1538-7445.AM2015-5363
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597106024
ER

PT J
AU Yuan, TL
   Bagni, R
   Yi, M
   Amzallag, A
   Afghani, S
   Beam, K
   Burgan, W
   Fer, N
   Garvey, L
   Smith, B
   Waters, A
   Stephens, R
   Benes, C
   McCormick, F
AF Yuan, Tina L.
   Bagni, Rachel
   Yi, Ming
   Amzallag, Arnaud
   Afghani, Shervin
   Beam, Katie
   Burgan, William
   Fer, Nicole
   Garvey, Leslie
   Smith, Brian
   Waters, Andrew
   Stephens, Robert
   Benes, Cyril
   McCormick, Frank
TI Next-generation screen for integrative subtyping and target discovery
   for KRAS-mutant cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yuan, Tina L.; Afghani, Shervin; McCormick, Frank] UCSF Helen Diller Comprehens Canc Ctr, San Francisco, CA USA.
   [Bagni, Rachel; Yi, Ming; Beam, Katie; Burgan, William; Fer, Nicole; Garvey, Leslie; Smith, Brian; Waters, Andrew; Stephens, Robert] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Res Technol Program, Frederick, MD USA.
   [Amzallag, Arnaud; Benes, Cyril] Massachusetts Gen Hosp, Ctr Canc, Dept Med, Boston, MA USA.
   [Amzallag, Arnaud; Benes, Cyril] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4690
DI 10.1158/1538-7445.AM2015-4690
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104318
ER

PT J
AU Zhang, SL
   Wei, JS
   Patidar, R
   Song, YK
   Sindiri, S
   Wen, XY
   Asgharzadeh, S
   Seeger, RC
   Maris, JM
   Auvil, JMG
   Gerhard, DS
   Khan, J
AF Zhang, Shile
   Wei, Jun S.
   Patidar, Rajesh
   Song, Young K.
   Sindiri, Sivasish
   Wen, Xinyu
   Asgharzadeh, Shahab
   Seeger, Robert C.
   Maris, John M.
   Auvil, Jamie M. Guidry
   Gerhard, Daniela S.
   Khan, Javed
TI Transcriptome characterization by RNA sequencing identifies molecular
   and clinical subgroups in high risk neuroblastoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Zhang, Shile; Wei, Jun S.; Patidar, Rajesh; Song, Young K.; Sindiri, Sivasish; Wen, Xinyu; Auvil, Jamie M. Guidry; Gerhard, Daniela S.; Khan, Javed] NCI, Bethesda, MD 20892 USA.
   [Asgharzadeh, Shahab; Seeger, Robert C.] Univ So Calif, Los Angeles, CA USA.
   [Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 3218
DI 10.1158/1538-7445.AM2015-3218
PG 1
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597101251
ER

PT J
AU Zhou, CK
   Levine, PH
   Cleary, SD
   Hoffman, HJ
   Graubard, BI
   Cook, MB
AF Zhou, Cindy Ke
   Levine, Paul H.
   Cleary, Sean D.
   Hoffman, Heather J.
   Graubard, Barry I.
   Cook, Michael B.
TI Male pattern baldness in relation to prostate cancer-specific mortality:
   A prospective analysis in the NHANES I Epidemiologic Followup Study
   (NHEFS)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Zhou, Cindy Ke; Graubard, Barry I.; Cook, Michael B.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Levine, Paul H.; Cleary, Sean D.; Hoffman, Heather J.] George Washington Univ, Dept Epidemiol & Biostat, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4603
DI 10.1158/1538-7445.AM2015-4603
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104231
ER

PT J
AU Zingone, A
   Brown, D
   Bowman, E
   Vidal, O
   Neal, J
   Sage, J
   Ryan, BM
AF Zingone, Adriana
   Brown, Derek
   Bowman, Elise
   Vidal, Oscar
   Neal, Joel
   Sage, Julien
   Ryan, Brid M.
TI Improved survival among lung cancer patients taking antidepressants
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Zingone, Adriana; Brown, Derek; Bowman, Elise; Vidal, Oscar; Ryan, Brid M.] NCI, Bethesda, MD 20892 USA.
   [Neal, Joel; Sage, Julien] Stanford Univ, Stanford, CA 94305 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA LB-182
DI 10.1158/1538-7445.AM2015-LB-182
PG 3
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597100282
ER

PT J
AU Aggarwal, M
   Sinclair, E
   Jacobs, A
   Fu, Y
   Dyba, M
   Wang, XT
   Cruz, IM
   Berry, D
   Bhaskar, K
   Mueller, SC
   Avantaggiati, ML
   Chung, FL
AF Aggarwal, Monika
   Sinclair, Elizabeth
   Jacobs, Anna
   Fu, Ying
   Dyba, Marcin
   Wang, Xiantao
   Cruz, Idalia M.
   Berry, Deborah
   Bhaskar, Kallakury
   Mueller, Susette C.
   Avantaggiati, Maria Laura
   Chung, Fung-Lung
TI Reactivation of p53R175 mutant by dietary phenethyl isothiocyanate
   (PEITC) impairs tumor growth in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Aggarwal, Monika; Sinclair, Elizabeth; Jacobs, Anna; Fu, Ying; Dyba, Marcin; Cruz, Idalia M.; Berry, Deborah; Mueller, Susette C.; Avantaggiati, Maria Laura; Chung, Fung-Lung] Gerogetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC USA.
   [Wang, Xiantao] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Bhaskar, Kallakury] MedStar Georgetown Univ Hosp, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1910
DI 10.1158/1538-7445.AM2015-1910
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504020
ER

PT J
AU Agrawal, L
   McAlister, F
   Roy, S
   Unger, F
   David, K
   Juhl, H
   Chelsky, D
   Moore, H
AF Agrawal, Lokesh
   McAlister, Fiona
   Roy, Sushmita
   Unger, Florian
   David, Kerstin
   Juhl, Harmut
   Chelsky, Daniel
   Moore, Helen
TI Proteomic changes observed in colon cancer tumors by label-free
   differential profiling of paired tumor versus normal FFPE samples
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Agrawal, Lokesh; Moore, Helen] NCI, Rockville, MD USA.
   [McAlister, Fiona; Roy, Sushmita; Chelsky, Daniel] Caprion Prote, Menlo Pk, CA USA.
   [Unger, Florian; David, Kerstin; Juhl, Harmut] Indivumed, Hamburg, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1562
DI 10.1158/1538-7445.AM2015-1562
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503056
ER

PT J
AU Al Abo, M
   Liu, XJ
   Plunkett, W
   Pommier, Y
AF Al Abo, Muthana
   Liu, Xiaojun
   Plunkett, William
   Pommier, Yves
TI Tyrosyl-DNA phosphodiesterase 1 (TDP1) is critical for the repair of DNA
   breaks induced by sapacitabine, a nucleoside antimetabolite in clinical
   trials targeted to ATM- and BRCA-deficient tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Al Abo, Muthana; Pommier, Yves] NCI, Dev Therapeut Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Al Abo, Muthana; Pommier, Yves] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Liu, Xiaojun; Plunkett, William] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2549
DI 10.1158/1538-7445.AM2015-2549
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505141
ER

PT J
AU Alan, BD
   Henrich, CJ
   Erickson, KL
   Thomas, CL
   Bokesch, HR
   Tewary, P
   Thompson, CR
   Pompei, RJ
   Gustafson, KR
   McMahon, JB
   Sayers, TJ
AF Alan, Brooks D.
   Henrich, Curtis J.
   Erickson, Karen L.
   Thomas, Cheryl L.
   Bokesch, Heidi R.
   Tewary, Poonam
   Thompson, Candace R.
   Pompei, Richard J.
   Gustafson, Kirk R.
   McMahon, James B.
   Sayers, Thomas J.
TI Withanolide E sensitizes renal carcinoma cells to TRAIL-induced
   apoptosis by increasing cFLIP degradation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Alan, Brooks D.; Henrich, Curtis J.; Bokesch, Heidi R.; Tewary, Poonam; Sayers, Thomas J.] NCI, Leidos Biomed Res Inc, Frederick, MD 21701 USA.
   [Erickson, Karen L.] Clark Univ, Worcester, MA 01610 USA.
   [Thomas, Cheryl L.; Thompson, Candace R.; Pompei, Richard J.; Gustafson, Kirk R.; McMahon, James B.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2928
DI 10.1158/1538-7445.AM2015-2928
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506074
ER

PT J
AU Alewine, CC
   Kolyvas, E
   Boslett, K
   Pastan, I
AF Alewine, Christine Campo
   Kolyvas, Emily
   Boslett, Klaus
   Pastan, Ira
TI Combination of taxanes with mesothelin-targeted immunotoxin RG7787
   induces synergistic killing of pancreatic cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Alewine, Christine Campo; Kolyvas, Emily; Pastan, Ira] NCI, Bethesda, MD 20892 USA.
   [Boslett, Klaus] Roche Pharma Res & Early Dev pRED, Penzburg, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2566
DI 10.1158/1538-7445.AM2015-2566
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505158
ER

PT J
AU Ameri, AH
   Yin, JJI
   Jansen, K
   Wang, SM
   Snyder, J
   Hynes, P
   Kelly, K
AF Ameri, Amir H.
   Yin, Juan Juan Ivy
   Jansen, Keith
   Wang, Simeng
   Snyder, Jessica
   Hynes, Paul
   Kelly, Kathleen
TI EGR1 is a mediator of TWEAK-Fn14 pathway induced prostate cancer bone
   metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ameri, Amir H.; Yin, Juan Juan Ivy; Jansen, Keith; Wang, Simeng; Snyder, Jessica; Hynes, Paul; Kelly, Kathleen] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 388
DI 10.1158/1538-7445.AM2015-388
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500369
ER

PT J
AU Andrade, KC
   Leite, AC
   Nobrega, A
   Savage, S
   Achatz, MI
AF Andrade, Kelvin Cesar
   Leite, Ana Carolina
   Nobrega, Amanda
   Savage, Sharon
   Achatz, Maria Isabel
TI The germline TP53 p.R337H mutation: a putative selective advantage
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Andrade, Kelvin Cesar; Nobrega, Amanda; Achatz, Maria Isabel] AC Camargo Canc Ctr, Sao Paulo, Brazil.
   [Leite, Ana Carolina] Inst Canc Ceara, Fortaleza, Ceara, Brazil.
   [Savage, Sharon] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2753
DI 10.1158/1538-7445.AM2015-2753
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505339
ER

PT J
AU Antony, S
   Wu, YZ
   Jiang, GJ
   Meitzler, JL
   Liu, H
   Juhasz, A
   Lu, JM
   Anver, MR
   Roy, KK
   Doroshow, JH
AF Antony, Smitha
   Wu, Yongzhong
   Jiang, Guojian
   Meitzler, Jennifer L.
   Liu, Han
   Juhasz, Agnes
   Lu, Jiamo
   Anver, Miriam R.
   Roy, Krishnendu K.
   Doroshow, James H.
TI Expression of NADPH oxidase 5 (Nox5) modulates cellular morphology,
   proliferation and invasiveness of human melanoma UACC-257 cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Antony, Smitha; Wu, Yongzhong; Jiang, Guojian; Meitzler, Jennifer L.; Juhasz, Agnes; Lu, Jiamo] NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA.
   [Liu, Han; Roy, Krishnendu K.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
   [Anver, Miriam R.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1251
DI 10.1158/1538-7445.AM2015-1251
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502291
ER

PT J
AU Antwi, S
   Steck, SE
   Su, LJ
   Hebert, JR
   Zhang, HM
   Fontham, ETH
   Bensen, JT
   Mohler, JL
   Arab, L
AF Antwi, Samuel
   Steck, Susan E.
   Su, L. Joseph
   Hebert, James R.
   Zhang, Hongmei
   Fontham, Elizabeth T. H.
   Bensen, Jeannette T.
   Mohler, James L.
   Arab, Lenore
TI Dietary, supplement, and adipose tissue tocopherol levels in relation to
   prostate cancer aggressiveness among African- and European-Americans
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Antwi, Samuel; Steck, Susan E.; Hebert, James R.] Univ S Carolina, Columbia, SC 29208 USA.
   [Su, L. Joseph] NCI, NIH, Rockville, MD USA.
   [Zhang, Hongmei] Univ Memphis, Memphis, TN 38152 USA.
   [Fontham, Elizabeth T. H.] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, New Orleans, LA USA.
   [Bensen, Jeannette T.] Univ N Carolina, Chapel Hill, NC USA.
   [Mohler, James L.] Roswell Pk Canc Inst, Dept Urol, Buffalo, NY 14263 USA.
   [Arab, Lenore] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1881
DI 10.1158/1538-7445.AM2015-1881
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503366
ER

PT J
AU Arem, H
   Park, Y
   Felix, A
   Zervoudakis, A
   Brinton, LA
   Matthews, CE
   Gunter, MJ
AF Arem, Hannah
   Park, Yikyung
   Felix, Ashley
   Zervoudakis, Alice
   Brinton, Louise A.
   Matthews, Charles E.
   Gunter, Marc J.
TI Reproductive and hormonal factors and mortality risk among women with
   colorectal cancer in the NIH-AARP Diet and Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Arem, Hannah; Felix, Ashley; Brinton, Louise A.; Matthews, Charles E.] NCI, Bethesda, MD 20892 USA.
   [Park, Yikyung] Washington Univ, Sch Med, Publ Hlth Serv, St Louis, MO USA.
   [Zervoudakis, Alice] Winthrop Univ Hosp, Mineola, NY 11501 USA.
   [Gunter, Marc J.] Univ London Imperial Coll Sci Technol & Med, London, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 888
DI 10.1158/1538-7445.AM2015-888
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501340
ER

PT J
AU Bae, WK
   Shim, HJ
   Cho, SH
   Chung, IJ
   Park, IK
   Hennighausen, L
AF Bae, Woo Kyun
   Shim, Hyun Jeong
   Cho, Sang Hee
   Chung, Ik-Joo
   Park, In-Kyu
   Hennighausen, Lothar
TI The role of methyltransferase, enhancer of zeste homolog 2 (EZH2) in
   mouse hepatocyte and human hepatocellular carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bae, Woo Kyun; Shim, Hyun Jeong; Cho, Sang Hee; Chung, Ik-Joo; Park, In-Kyu] Chonnam Natl Univ, Hwasun Hosp, Hwasun Gun, South Korea.
   [Hennighausen, Lothar] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2304
DI 10.1158/1538-7445.AM2015-2304
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504406
ER

PT J
AU Bailey-Wilson, JE
   Simpson, CL
   Pinney, SM
   de Andrade, M
   Gaba, C
   Yang, P
   You, M
   Kupert, EY
   Schwartz, AG
   Mandal, D
   Amos, CI
   Anderson, MW
AF Bailey-Wilson, Joan E.
   Simpson, Claire L.
   Pinney, Susan M.
   de Andrade, Mariza
   Gaba, Colette
   Yang, Ping
   You, Ming
   Kupert, Elena Y.
   Schwartz, Ann G.
   Mandal, Diptasri
   Amos, Christopher I.
   Anderson, Marshall W.
TI Evaluation of EYA4 as a candidate risk locus in familial lung cancer
   families linked to 6q
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bailey-Wilson, Joan E.; Simpson, Claire L.] NHGRI, NIH, Baltimore, MD USA.
   [Pinney, Susan M.] Univ Cincinnati, Coll Med, Cincinnati, OH USA.
   [de Andrade, Mariza; Yang, Ping] Mayo Clin, Rochester, MN USA.
   [Gaba, Colette] Univ Toledo, Dana Canc Ctr, Toledo, OH 43606 USA.
   [You, Ming; Kupert, Elena Y.; Anderson, Marshall W.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Schwartz, Ann G.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA.
   [Mandal, Diptasri] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
   [Amos, Christopher I.] Dartmouth Coll, Geisel Sch Med, Lebanon, NH 03756 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2757
DI 10.1158/1538-7445.AM2015-2757
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505343
ER

PT J
AU Basseville, A
   Sourbier, C
   Robey, RW
   Sackett, DL
   Linehan, WM
   Bates, SE
AF Basseville, Agnes
   Sourbier, Carole
   Robey, Robert W.
   Sackett, Dan L.
   Linehan, W. Marston
   Bates, Susan E.
TI Metabolic reprogramming in KRAS mutant cancer cells may cause
   sensitivity to the histone deacetylase (HDAC) inhibitor romidepsin
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Basseville, Agnes; Sourbier, Carole; Robey, Robert W.; Linehan, W. Marston; Bates, Susan E.] NCI, NIH, Bethesda, MD 20892 USA.
   [Sackett, Dan L.] NICHD, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1771
DI 10.1158/1538-7445.AM2015-1771
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503256
ER

PT J
AU Bassig, BA
   Shu, XO
   Koh, WP
   Gao, YT
   Purdue, MP
   Butler, LM
   Adams-Haduch, J
   Xiang, YB
   Kemp, TJ
   Wang, RW
   Pinto, LA
   Zheng, TZ
   Ji, BT
   Hosgood, HD
   Hui, W
   Yang, G
   Zhang, HP
   Chow, WH
   Kim, C
   Seow, WJ
   Zheng, W
   Yuan, JM
   Lan, Q
   Rothman, N
AF Bassig, Bryan A.
   Shu, Xiao-Ou
   Koh, Woon-Puay
   Gao, Yu-Tang
   Purdue, Mark P.
   Butler, Lesley M.
   Adams-Haduch, Jennifer
   Xiang, Yong-Bing
   Kemp, Troy J.
   Wang, Renwei
   Pinto, Ligia A.
   Zheng, Tongzhang
   Ji, Bu-Tian
   Hosgood, H. Dean
   Hui, Wei
   Yang, Gong
   Zhang, Heping
   Chow, Wong-Ho
   Kim, Christopher
   Seow, Wei Jie
   Zheng, Wei
   Yuan, Jian-Min
   Lan, Qing
   Rothman, Nathaniel
TI Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin
   lymphoma in a pooled analysis of three prospective cohorts of Chinese
   men and women in Shanghai and Singapore
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bassig, Bryan A.; Ji, Bu-Tian; Hui, Wei; Kim, Christopher; Seow, Wei Jie; Lan, Qing; Rothman, Nathaniel] NCI DCEG, Rockville, MD USA.
   [Shu, Xiao-Ou; Yang, Gong; Zheng, Wei] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Koh, Woon-Puay] Duke NUS Grad Med Sch, Singapore, Singapore.
   [Gao, Yu-Tang] Shanghai Canc Inst, Shanghai, Peoples R China.
   [Purdue, Mark P.] Ontario Inst Canc Res, Toronto, ON, Canada.
   [Butler, Lesley M.; Adams-Haduch, Jennifer; Wang, Renwei; Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Xiang, Yong-Bing] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, Sch Med, Shanghai 200030, Peoples R China.
   [Kemp, Troy J.; Pinto, Ligia A.] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Frederick, MD USA.
   [Zheng, Tongzhang; Zhang, Heping] Yale Univ, New Haven, CT USA.
   [Hosgood, H. Dean] Albent Einstein Coll Med, Bronx, NY USA.
   [Chow, Wong-Ho] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 846
DI 10.1158/1538-7445.AM2015-846
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501299
ER

PT J
AU Boudreau, HE
   Park, JJ
   Leto, TL
AF Boudreau, Howard E.
   Park, Jonathan J.
   Leto, Thomas L.
TI Transcriptional co-regulation of Nox4 by p53 and SMAD3
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Boudreau, Howard E.; Park, Jonathan J.; Leto, Thomas L.] NIAID, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2215
DI 10.1158/1538-7445.AM2015-2215
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504320
ER

PT J
AU Bradley, MC
   Black, A
   Freedman, AN
   Hoover, RN
   Visvanathan, KV
   Barron, TI
AF Bradley, Marie C.
   Black, Amanda
   Freedman, Andrew N.
   Hoover, Robert N.
   Visvanathan, Kala Visvanathan
   Barron, Thomas I.
TI Pre-diagnostic aspirin use, lymph node involvement and mortality in
   women with stage I-III breast cancer: A study in the Prostate Lung
   Colorectal and Ovarian cancer screening trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Bradley, Marie C.; Black, Amanda; Freedman, Andrew N.; Hoover, Robert N.] NCI, Rockville, MD USA.
   [Visvanathan, Kala Visvanathan; Barron, Thomas I.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 878
DI 10.1158/1538-7445.AM2015-878
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501330
ER

PT J
AU Castro, NP
   Rangel, CM
   Salomon, D
   Saylor, K
   Kim, YS
AF Castro, Nadia P.
   Rangel, Cristina M.
   Salomon, David
   Saylor, Karen
   Kim, Young S.
TI Sulforaphane suppresses the growth of triple-negative breast cancer
   stem-like cells in vitro and in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Castro, Nadia P.; Rangel, Cristina M.; Salomon, David; Saylor, Karen] NCI, Frederick, MD 21701 USA.
   [Kim, Young S.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 912
DI 10.1158/1538-7445.AM2015-912
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501363
ER

PT J
AU Chang, WCL
   Kaunga, E
   Cooper, HS
   Vanderveer, L
   Peng, J
   Zhang, Y
   Suen, CS
   Clapper, ML
AF Chang, Wen-Chi L.
   Kaunga, Esther
   Cooper, Harry S.
   Vanderveer, Lisa
   Peng, Jing
   Zhang, Yongchao
   Suen, Chen S.
   Clapper, Margie L.
TI Effect of ED-71, an analogue of Vitamin D3, on intestinal neoplasia in
   the Apc plus /Min-FCCC mouse model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chang, Wen-Chi L.; Kaunga, Esther; Cooper, Harry S.; Vanderveer, Lisa; Peng, Jing; Zhang, Yongchao; Clapper, Margie L.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
   [Suen, Chen S.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2806
DI 10.1158/1538-7445.AM2015-2806
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505390
ER

PT J
AU Chen, ZS
   Shojaee, S
   Buchner, M
   Geng, HM
   Lee, JW
   Klemm, L
   Park, E
   Tan, YX
   Satterthwaite, A
   Paietta, E
   Hunger, SP
   Loh, ML
   Jung, JU
   Coligan, JE
   Bolland, S
   Mak, TW
   Limnander, A
   Jumaa, H
   Reth, M
   Weiss, A
   Lowell, CA
   Muschen, M
AF Chen, Zhengshan
   Shojaee, Seyedmehdi
   Buchner, Maike
   Geng, Huimin
   Lee, Jae Woong
   Klemm, Lars
   Park, Eugene
   Tan, Ying Xim
   Satterthwaite, Anne
   Paietta, Elisabeth
   Hunger, Stephen P.
   Loh, Mignon L.
   Jung, Jae U.
   Coligan, John E.
   Bolland, Silvia
   Mak, Tak W.
   Limnander, Andre
   Jumaa, Hassan
   Reth, Michael
   Weiss, Arthur
   Lowell, Clifford A.
   Mueschen, Markus
TI Signaling thresholds and negative B cell selection in acute
   lymphoblastic leukemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chen, Zhengshan; Shojaee, Seyedmehdi; Buchner, Maike; Geng, Huimin; Lee, Jae Woong; Klemm, Lars; Park, Eugene; Tan, Ying Xim; Loh, Mignon L.; Limnander, Andre; Weiss, Arthur; Lowell, Clifford A.; Mueschen, Markus] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Satterthwaite, Anne] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Paietta, Elisabeth] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Hunger, Stephen P.] Univ Colorado, Sch Med, Aurora, CO USA.
   [Hunger, Stephen P.] Childrens Hosp Colorado, Aurora, CO USA.
   [Jung, Jae U.] Univ So Calif, Los Angeles, CA USA.
   [Coligan, John E.; Bolland, Silvia] NIAID, Rockville, MD USA.
   [Mak, Tak W.] Campbell Family Inst Canc Res, Toronto, ON, Canada.
   [Mak, Tak W.] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada.
   [Jumaa, Hassan] Univ Ulm, D-89069 Ulm, Germany.
   [Reth, Michael] Univ Freiburg, D-79106 Freiburg, Germany.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2075
DI 10.1158/1538-7445.AM2015-2075
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504181
ER

PT J
AU Chien, CD
   Nguyen, S
   Qin, HY
   Fry, TJ
AF Chien, Christopher D.
   Nguyen, Sang
   Qin, Haiying
   Fry, Terry J.
TI Inflammatory cytokine induced TSLP from bone marrow niches contributes
   to relapse of high risk TSLPR overexpressing acute lymphoblastic
   leukemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chien, Christopher D.; Nguyen, Sang; Qin, Haiying; Fry, Terry J.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2372
DI 10.1158/1538-7445.AM2015-2372
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504473
ER

PT J
AU Chowdhury, SA
   Gertz, EM
   Wangsa, D
   Heselmeyer-Haddad, K
   Ried, T
   Schaeffer, A
   Schwartz, R
AF Chowdhury, Salim A.
   Gertz, E. Michael
   Wangsa, Darawalee
   Heselmeyer-Haddad, Kerstin
   Ried, Thomas
   Schaeffer, Alejandro
   Schwartz, Russell
TI Reconstructing evolutionary models of tumor progression from single-cell
   heterogeneity data
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chowdhury, Salim A.; Schwartz, Russell] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
   [Gertz, E. Michael; Schaeffer, Alejandro] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA.
   [Wangsa, Darawalee; Heselmeyer-Haddad, Kerstin; Ried, Thomas] NCI, NIH, Bethesda, MD 20892 USA.
RI Schwartz, Russell/A-1998-2016
OI Schwartz, Russell/0000-0002-4970-2252
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2182
DI 10.1158/1538-7445.AM2015-2182
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504287
ER

PT J
AU Chung, E
   White, A
   Scroggins, BT
   McKay-Corkum, GB
   Mulligan-Kehoe, MJ
   Citrin, DE
AF Chung, Eunjoo
   White, Ayla
   Scroggins, Bradley T.
   McKay-Corkum, Grace B.
   Mulligan-Kehoe, Mary Jo
   Citrin, Deborah E.
TI A truncated Plasminogen Activator Inhibitor-1 protein protects from
   pulmonary fibrosis mediated by irradiation in a murine model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Chung, Eunjoo; White, Ayla; Scroggins, Bradley T.; McKay-Corkum, Grace B.; Citrin, Deborah E.] NIH, Bethesda, MD 20892 USA.
   [Mulligan-Kehoe, Mary Jo] Geisel Sch Med Dartmouth, Lebanon, NH USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1803
DI 10.1158/1538-7445.AM2015-1803
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503288
ER

PT J
AU Conkrite, K
   Ferraro, N
   McDaniel, L
   Oldridge, DA
   Attiyeh, E
   Asgharzadeh, S
   Diamond, M
   Auvil, JG
   Davidsen, T
   Smith, M
   London, WB
   Seeger, R
   Khan, J
   Gerhard, DS
   Maris, JM
   Diskin, SJ
AF Conkrite, Karina
   Ferraro, Nicole
   McDaniel, Lee
   Oldridge, Derek A.
   Attiyeh, Edward
   Asgharzadeh, Shahab
   Diamond, Maura
   Auvil, Jaime Guidry
   Davidsen, Tanja
   Smith, Malcom
   London, Wendy B.
   Seeger, Robert
   Khan, Javed
   Gerhard, Daniela S.
   Maris, John M.
   Diskin, Sharon J.
TI Identification of SHANK2 as a tumor suppressor disrupted by recurrent
   somatic structural variation (SV) in neuroblastoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Conkrite, Karina; Ferraro, Nicole; McDaniel, Lee; Oldridge, Derek A.; Attiyeh, Edward; Diamond, Maura; Maris, John M.; Diskin, Sharon J.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Asgharzadeh, Shahab; Seeger, Robert] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
   [Auvil, Jaime Guidry; Davidsen, Tanja; Smith, Malcom; Khan, Javed; Gerhard, Daniela S.] NCI, Bethesda, MD 20892 USA.
   [London, Wendy B.] Boston Childrens Hosp, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 475
DI 10.1158/1538-7445.AM2015-475
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500453
ER

PT J
AU Conley, BA
   Ivy, SP
   Tricoli, JV
   Zenklusen, JC
   Tarnuzzer, R
   Lubensky, I
   Takebe, N
   Williams, PM
   Zujewski, J
   Little, R
   White, J
   Kohn, E
   Malik, S
   Kim, B
   Souhan, E
   Staudt, L
AF Conley, Barbara A.
   Ivy, S. Percy
   Tricoli, James V.
   Zenklusen, Jean-Claude
   Tarnuzzer, Roy
   Lubensky, Irina
   Takebe, Naoko
   Williams, Paul M.
   Zujewski, JoAnne
   Little, Richard
   White, Jeffrey
   Kohn, Elise
   Malik, Shakun
   Kim, Ben
   Souhan, Erin
   Staudt, Lou
TI The NCI exceptional responders initiatives: Initial feasibility result
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Conley, Barbara A.; Ivy, S. Percy; Tricoli, James V.; Lubensky, Irina; Takebe, Naoko; Zujewski, JoAnne; Little, Richard; White, Jeffrey; Kohn, Elise; Malik, Shakun; Kim, Ben; Souhan, Erin] NCI, DCTD, Rockville, MD USA.
   [Zenklusen, Jean-Claude; Tarnuzzer, Roy] NCI, Bethesda, MD 20892 USA.
   [Williams, Paul M.] NCI, FNLCR, Frederick, MD 21701 USA.
   [Staudt, Lou] NCI, DCTD, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 612
DI 10.1158/1538-7445.AM2015-612
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501069
ER

PT J
AU Cook, MB
   Drahos, J
   Wood, S
   Enewold, L
   Parsons, R
   Freedman, ND
   Taylor, PR
   Ricker, W
   Abnet, CC
AF Cook, Michael B.
   Drahos, Jennifer
   Wood, Shannon
   Enewold, Lindsey
   Parsons, Ruth
   Freedman, Neal D.
   Taylor, Philip R.
   Ricker, Winnie
   Abnet, Christian C.
TI Pathogenesis and progression of esophageal adenocarcinoma by prior
   diagnosis of Barrett's esophagus
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Cook, Michael B.; Drahos, Jennifer; Wood, Shannon; Enewold, Lindsey; Freedman, Neal D.; Taylor, Philip R.; Abnet, Christian C.] NCI, Rockville, MD USA.
   [Parsons, Ruth; Ricker, Winnie] IMS, Rockville, MD USA.
RI Abnet, Christian/C-4111-2015
OI Abnet, Christian/0000-0002-3008-7843
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 837
DI 10.1158/1538-7445.AM2015-837
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501290
ER

PT J
AU Dai, YF
   Zhang, R
   Niu, Y
   Duan, HW
   Meng, T
   Ye, M
   Shen, ML
   Bin, P
   Yu, SF
   Vermeulen, R
   Rothman, N
   Lan, Q
   Zheng, YX
AF Dai, Yufei
   Zhang, Rong
   Niu, Yong
   Duan, Huawei
   Meng, Tao
   Ye, Meng
   Shen, Meili
   Bin, Ping
   Yu, Shanfa
   Vermeulen, Roel
   Rothman, Nathaniel
   Lan, Qing
   Zheng, Yuxin
TI Effects of occupational exposure to carbon black on peripheral white
   blood cell counts
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Dai, Yufei; Niu, Yong; Duan, Huawei; Meng, Tao; Ye, Meng; Shen, Meili; Bin, Ping; Zheng, Yuxin] China CDC, Natl Inst Occupat Hlth & Poison Control, Beijing, Peoples R China.
   [Zhang, Rong] Hebei Med Univ, Sch Publ Hlth, Dept Toxicol, Shijiazhuang, Peoples R China.
   [Yu, Shanfa] Henan Prov Inst Occupat Hlth, Zhengzhou, Peoples R China.
   [Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
   [Rothman, Nathaniel; Lan, Qing] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 839
DI 10.1158/1538-7445.AM2015-839
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501292
ER

PT J
AU de Magalhaes, N
   Murakami, T
   Heim, R
   Makings, L
   Garcia-Guzman, M
   Kobayashi, H
   Hoffman, RM
   Bouvet, M
AF de Magalhaes, Nzola
   Murakami, Takashi
   Heim, Roger
   Makings, Lew
   Garcia-Guzman, Miguel
   Kobayashi, Hisataka
   Hoffman, Robert M.
   Bouvet, Michael
TI Photoimmunotherapy with an anti-EGFR antibody conjugated to an IRDye700
   results in extensive and rapid cell death in vitro and in vivo in human
   pancreatic cancer cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [de Magalhaes, Nzola; Hoffman, Robert M.; Bouvet, Michael] UCSD Med Ctr, San Diego, CA USA.
   [Murakami, Takashi] Yokohama City Grad Sch Med, Yokohama, Kanagawa, Japan.
   [Heim, Roger; Makings, Lew; Garcia-Guzman, Miguel] Aspyrian Therapeut Inc, San Diego, CA USA.
   [Kobayashi, Hisataka] NIH, Bethesda, MD 20892 USA.
   [Hoffman, Robert M.] AntiCancer Inc, San Diego, CA USA.
OI De Magalhaes, Nzola/0000-0001-7912-1072
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2019
DI 10.1158/1538-7445.AM2015-2019
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504126
ER

PT J
AU Dine, JL
   Garimella, SV
   Gehlhaus, K
   Grandin, M
   Letwin, D
   Caplen, N
   Lipkowitz, S
AF Dine, Jennifer L.
   Garimella, Sireesha V.
   Gehlhaus, Kristie
   Grandin, Magda
   Letwin, Daniel
   Caplen, Natasha
   Lipkowitz, Stanley
TI gp78 is a negative regulator of TRAIL-induced apoptosis in breast cancer
   cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Dine, Jennifer L.; Garimella, Sireesha V.; Letwin, Daniel; Lipkowitz, Stanley] NCI, Womens Malignancies Branch, NIH, Bethesda, MD 20892 USA.
   [Dine, Jennifer L.] NINR, Div Intramural Res, NIH, Bethesda, MD 20892 USA.
   [Gehlhaus, Kristie; Grandin, Magda; Caplen, Natasha] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 15
DI 10.1158/1538-7445.AM2015-15
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500014
ER

PT J
AU Downey, R
   Murillo, L
   McHale, T
   Wallace, T
   Seufert, C
   Schetter, A
   Dorsey, T
   Johnson, C
   Goldman, R
   Loffredo, C
   Yan, PS
   Sullivan, F
   Giles, F
   Wang-Johanning, F
   Ambs, S
   Glynn, S
AF Downey, Ronan
   Murillo, Laura
   McHale, Teresa
   Wallace, Tiffany
   Seufert, Caleb
   Schetter, Aaron
   Dorsey, Tiffany
   Johnson, Carol
   Goldman, Radoslav
   Loffredo, Christopher
   Yan, Peisha
   Sullivan, Francis
   Giles, Francis
   Wang-Johanning, Feng
   Ambs, Stefan
   Glynn, Sharon
TI Human endogenous retrovirus K expression as a possible adjunct to PSA in
   the diagnosis of prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Downey, Ronan; Johnson, Carol; Sullivan, Francis; Giles, Francis; Glynn, Sharon] NUI Galway, Prostate Canc Inst, Galway, Ireland.
   [Murillo, Laura; McHale, Teresa] NUI Galway, Galway, Ireland.
   [Wallace, Tiffany; Seufert, Caleb; Schetter, Aaron; Dorsey, Tiffany; Ambs, Stefan] NCI, Bethesda, MD 20892 USA.
   [Goldman, Radoslav; Loffredo, Christopher] Georgetown Univ, Washington, DC USA.
   [Yan, Peisha] Univ Texas Houston, Houston, TX USA.
   [Wang-Johanning, Feng] SRI Int, Menlo Pk, CA 94025 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 536
DI 10.1158/1538-7445.AM2015-536
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500511
ER

PT J
AU Dunn, BK
   Steele, VE
   Fagerstrom, RM
   Topp, CF
   Kramer, BS
AF Dunn, Barbara K.
   Steele, Vernon E.
   Fagerstrom, Richard M.
   Topp, Carol F.
   Kramer, Barnett S.
TI Chemoprevention of mammary cancer: Modeling predictive values of
   short-term morphologic assays for efficacy in animal tumor assays
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Dunn, Barbara K.; Steele, Vernon E.; Fagerstrom, Richard M.; Kramer, Barnett S.] NCI, Bethesda, MD 20892 USA.
   [Topp, Carol F.] CCS Associates, Mclean, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2813
DI 10.1158/1538-7445.AM2015-2813
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505397
ER

PT J
AU Eggert, T
   Ji, JL
   Zender, L
   Wang, XW
   Greten, TF
AF Eggert, Tobias
   Ji, Juling
   Zender, Lars
   Wang, Xin Wei
   Greten, Tim F.
TI Senescent hepatocytes secrete CCL2 to accelerate liver cancer growth via
   accumulation of immunosuppressive myeloid cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Eggert, Tobias; Wang, Xin Wei; Greten, Tim F.] NCI, Bethesda, MD 20892 USA.
   [Ji, Juling] Nantong Univ, Sch Med, Nantong, Peoples R China.
   [Zender, Lars] Univ Tubingen, Tubingen, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 360
DI 10.1158/1538-7445.AM2015-360
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500341
ER

PT J
AU Eldridge, RC
   Pawlita, M
   Wilson, L
   Castle, PE
   Waterboer, T
   Gravitt, PE
   Schiffman, M
   Wentzensen, N
AF Eldridge, Ronald C.
   Pawlita, Michael
   Wilson, Lauren
   Castle, Philip E.
   Waterboer, Tim
   Gravitt, Patti E.
   Schiffman, Mark
   Wentzensen, Nicolas
TI Smoking and HPV antibodies, a mediation analysis of HPV re-infection
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Eldridge, Ronald C.; Schiffman, Mark; Wentzensen, Nicolas] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Pawlita, Michael; Waterboer, Tim] German Canc Res Ctr, Heidelberg, Germany.
   [Wilson, Lauren] NIEHS, Res Triangle Pk, NC 27709 USA.
   [Castle, Philip E.] Global Coalit Cerv Canc, Arlington, VA USA.
   [Gravitt, Patti E.] Univ New Mexico, Albuquerque, NM 87131 USA.
RI Waterboer, Tim/G-1252-2010
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 852
DI 10.1158/1538-7445.AM2015-852
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501305
ER

PT J
AU Esposito, D
AF Esposito, Dominic
TI Development of reference reagents to accelerate research on the RAS
   pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Esposito, Dominic] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 4
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2151
DI 10.1158/1538-7445.AM2015-2151
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504256
ER

PT J
AU Falk, RT
   Staff, AC
   Bradwin, G
   Karumanchi, A
   Troisi, R
AF Falk, Roni T.
   Staff, Annetine C.
   Bradwin, Gary
   Karumanchi, Ananth
   Troisi, Rebecca
TI Angiogenic profile in postmenopausal women is not associated with breast
   cancer risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Falk, Roni T.; Troisi, Rebecca] NCI, Bethesda, MD 20892 USA.
   [Staff, Annetine C.] Oslo Univ Hosp, N-0450 Oslo, Norway.
   [Bradwin, Gary] Childrens Hosp, Boston, MA 02115 USA.
   [Karumanchi, Ananth] Harvard Univ, Sch Med, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2769
DI 10.1158/1538-7445.AM2015-2769
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505355
ER

PT J
AU Fanidi, A
   Muller, D
   Prentice, R
   Demetrius, A
   Yuan, JM
   Stevens, V
   Weinstein, SJ
   Johansson, M
   Brennan, P
AF Fanidi, Anouar
   Muller, David.
   Prentice, Ross
   Demetrius, Albanes
   Yuan, Jian-Min
   Stevens, Victoria
   Weinstein, Stephanie J.
   Johansson, Mattias
   Brennan, Paul
CA Lung Canc Cohort Consortium LC3
TI Circulating biomarkers of B vitamins in relation to lung cancer risk in
   the Lung Cancer Cohort Consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Fanidi, Anouar; Muller, David.; Johansson, Mattias; Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
   [Prentice, Ross] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Demetrius, Albanes; Weinstein, Stephanie J.] NCI, NIH, Bethesda, MD 20892 USA.
   [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Stevens, Victoria] Amer Canc Soc, Epidemiol Res, Atlanta, GA 30329 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 933
DI 10.1158/1538-7445.AM2015-933
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501384
ER

PT J
AU Felix, AS
   Lenz, P
   Pfeiffer, RM
   Hewitt, SM
   Morris, J
   Patel, D
   Geller, B
   Vacek, PM
   Weaver, DL
   Chicoine, RE
   Shepherd, J
   Mahmoudzadeh, AP
   Wang, J
   Fan, B
   Herschorn, S
   Johnson, J
   Brinton, LA
   Sherman, ME
   Gierach, GL
AF Felix, Ashley S.
   Lenz, Petra
   Pfeiffer, Ruth M.
   Hewitt, Stephen M.
   Morris, Jennifer
   Patel, Deesha
   Geller, Berta
   Vacek, Pamela M.
   Weaver, Donald L.
   Chicoine, Rachael E.
   Shepherd, John
   Mahmoudzadeh, Amir P.
   Wang, Jeff
   Fan, Bo
   Herschorn, Sally
   Johnson, Jason
   Brinton, Louise A.
   Sherman, Mark E.
   Gierach, Gretchen L.
TI Relationships between mammographic density, microvessel density, and
   breast biopsy diagnosis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Felix, Ashley S.; Pfeiffer, Ruth M.; Hewitt, Stephen M.; Morris, Jennifer; Patel, Deesha; Brinton, Louise A.; Sherman, Mark E.; Gierach, Gretchen L.] NCI, Bethesda, MD 20892 USA.
   [Lenz, Petra] Leidos Biomed Res Inc, Clin Res Directorate, Clin Monitoring Res Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Geller, Berta; Vacek, Pamela M.; Weaver, Donald L.; Chicoine, Rachael E.; Herschorn, Sally] Univ Vermont, Burlington, VT USA.
   [Shepherd, John; Mahmoudzadeh, Amir P.; Fan, Bo] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA.
   [Wang, Jeff] Hokkaido Univ, Sapporo, Hokkaido, Japan.
   [Johnson, Jason] Univ Texas Houston, MD Anderson Canc Ctr, Dept Diagnost Radiol, Neuroradiol Sect, Houston, TX 77030 USA.
RI Gierach, Gretchen/E-1817-2016
OI Gierach, Gretchen/0000-0002-0165-5522
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2768
DI 10.1158/1538-7445.AM2015-2768
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505354
ER

PT J
AU Finnberg, NK
   Gokare, P
   Navaraj, A
   Kuhs, KAL
   Cerniglia, G
   Yagita, H
   Takeda, K
   Motoyama, N
   El-Deiry, WS
AF Finnberg, Niklas K.
   Gokare, Prashanth
   Navaraj, Arunasalam
   Kuhs, Krystle A. Lang
   Cerniglia, George
   Yagita, Hideo
   Takeda, Kazuyoshi
   Motoyama, Noboru
   El-Deiry, Wafik S.
TI DR5-targeting sensitizes Lgr5+stem cells to p53 and Chk2-dependent
   chemotherapy-induced cell death and produces dose-limiting
   gastrointestinal toxicity (GIT)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Finnberg, Niklas K.; Gokare, Prashanth; El-Deiry, Wafik S.] Fox Chase Canc Ctr, Dept Med Oncol, Lab Translat Oncol & Expt Canc Therapeut, Philadelphia, PA 19111 USA.
   [Finnberg, Niklas K.; Gokare, Prashanth; El-Deiry, Wafik S.] Fox Chase Canc Ctr, Mol Therapeut Program, Philadelphia, PA 19111 USA.
   [Navaraj, Arunasalam] Penn State Hershey Canc Inst, Hershey, PA USA.
   [Kuhs, Krystle A. Lang] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Infect, Bethesda, MD 20892 USA.
   [Cerniglia, George] Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA.
   [Yagita, Hideo; Takeda, Kazuyoshi] Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan.
   [Motoyama, Noboru] Natl Ctr Geriatr & Gerontol, Res Inst, Dept Cognit Brain Sci, Obu, Aichi, Japan.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2926
DI 10.1158/1538-7445.AM2015-2926
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506072
ER

PT J
AU Gangjee, A
   Xiang, WG
   Mooberry, SL
   Hamel, E
AF Gangjee, Aleem
   Xiang, Weiguo
   Mooberry, Susan L.
   Hamel, Ernest
TI Design, synthesis, biological evaluation of cyclopenta[d]pyrimidines as
   antitubulin agents and discovery of N-(4-methylthiophenyl) and
   N-(4-dimethylaminophenyl) substituted
   N,2-dimethyl-cyclopenta[d]pyrimidines as long acting and poten
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Gangjee, Aleem; Xiang, Weiguo] Duquesne Univ, Pittsburgh, PA 15219 USA.
   [Mooberry, Susan L.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
   [Hamel, Ernest] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1665
DI 10.1158/1538-7445.AM2015-1665
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503156
ER

PT J
AU Gary, JM
   Xu, JF
   Simmons, J
   Zhang, SL
   Gamache, B
   Zhang, K
   Kovalchuk, A
   Michalowski, A
   Chen, JQ
   Herrmann, M
   Dubois, W
   Testa, J
   Mock, BA
AF Gary, Joy M.
   Xu, Jinfei
   Simmons, John
   Zhang, Shuling
   Gamache, Benjamin
   Zhang, Ke
   Kovalchuk, Alexander
   Michalowski, Aleksandra
   Chen, Jin-Qiu
   Herrmann, Michelle
   Dubois, Wendy
   Testa, Joseph
   Mock, Beverly A.
TI Murine model of dual mTORC kinase inhibition identifies CDK6 as a
   synergistic target in T-ALL
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Gary, Joy M.; Simmons, John; Zhang, Shuling; Gamache, Benjamin; Zhang, Ke; Michalowski, Aleksandra; Chen, Jin-Qiu; Herrmann, Michelle; Dubois, Wendy; Mock, Beverly A.] NCI, Bethesda, MD 20892 USA.
   [Xu, Jinfei] Univ Penn, Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA.
   [Kovalchuk, Alexander] NIAID, Rockville, MD USA.
   [Testa, Joseph] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2309
DI 10.1158/1538-7445.AM2015-2309
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504411
ER

PT J
AU Grohar, PJ
   Kim, S
   Haddock, S
   Rivera, GR
   Harlow, M
   Maloney, NK
   Huppi, K
   Gehlhaus, K
   Grandin, M
   Klumpp-Thomas, C
   Buehler, E
   Helman, LJ
   Martin, SE
   Caplen, NJ
AF Grohar, Patrick J.
   Kim, Suntae
   Haddock, Sara
   Rivera, Guillermo Rangel
   Harlow, Matt
   Maloney, Nichole K.
   Huppi, Konrad
   Gehlhaus, Kristen
   Grandin, Magdalena
   Klumpp-Thomas, Carleen
   Buehler, Eugen
   Helman, Lee J.
   Martin, Scott E.
   Caplen, Natasha J.
TI Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses
   EWS-FLI1 driven oncogenic expression in Ewing sarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Grohar, Patrick J.; Harlow, Matt; Maloney, Nichole K.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
   [Kim, Suntae; Haddock, Sara; Rivera, Guillermo Rangel; Huppi, Konrad; Gehlhaus, Kristen; Grandin, Magdalena; Caplen, Natasha J.] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Klumpp-Thomas, Carleen; Buehler, Eugen; Martin, Scott E.] NIH, Trans NIH RNAi Screening Facil, Div Preclin Innovat, Natl Ctr Adv Translat Sci, Rockville, MD USA.
   [Helman, Lee J.] NCI, Pediat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 479
DI 10.1158/1538-7445.AM2015-479
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500457
ER

PT J
AU Grubbs, CJ
   Miller, MS
   Steele, VE
   Moeinpour, F
   Seifried, H
   Heckman-Stoddard, BM
   Lubet, RA
AF Grubbs, Clinton J.
   Miller, Mark S.
   Steele, Vernon E.
   Moeinpour, Fariba
   Seifried, Harold
   Heckman-Stoddard, Brandy M.
   Lubet, Ronald A.
TI Chemopreventive studies of multiple agents in the
   methylnitrosourea-induced ER+ mammary cancer model in animals on
   standard and Western diets
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Grubbs, Clinton J.; Moeinpour, Fariba] Univ Alabama Birmingham, Comp Canc Ctr, Birmingham, AL USA.
   [Miller, Mark S.; Steele, Vernon E.; Seifried, Harold; Heckman-Stoddard, Brandy M.; Lubet, Ronald A.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2809
DI 10.1158/1538-7445.AM2015-2809
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505393
ER

PT J
AU Gundem, G
   Van Loo, P
   Kremeyer, B
   Alexandrov, LB
   Tubio, JMC
   Papaemmanuil, E
   Brewer, DS
   Kallio, H
   Hognas, G
   Annala, M
   Kivinummi, K
   Goody, V
   Latimer, C
   O'Meara, S
   Dawson, KJ
   Isaacs, W
   Emmert-Buck, MR
   Nykter, M
   Foster, C
   Kote-Jarai, Z
   Easton, D
   Whitaker, HC
   Neal, DE
   Cooper, CS
   Eeles, RA
   Visakorpi, T
   Campbell, PJ
   McDermott, U
   Wedge, DC
   Bova, GS
AF Gundem, Gunes
   Van Loo, Peter
   Kremeyer, Barbara
   Alexandrov, Ludmil B.
   Tubio, Jose M. C.
   Papaemmanuil, Elli
   Brewer, Daniel S.
   Kallio, Heini
   Hognas, Gunilla
   Annala, Math
   Kivinummi, Kati
   Goody, Victoria
   Latimer, Calli
   O'Meara, Sarah
   Dawson, Kevin J.
   Isaacs, William
   Emmert-Buck, Michael R.
   Nykter, Matti
   Foster, Christopher
   Kote-Jarai, Zsofia
   Easton, Douglas
   Whitaker, Hayley C.
   Neal, David E.
   Cooper, Colin S.
   Eeles, Rosalind A.
   Visakorpi, Tapio
   Campbell, Peter J.
   McDermott, Ultan
   Wedge, David C.
   Bova, G. S.
TI The evolutionary history of lethal metastatic prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Gundem, Gunes; Van Loo, Peter; Kremeyer, Barbara; Alexandrov, Ludmil B.; Tubio, Jose M. C.; Papaemmanuil, Elli; Goody, Victoria; Latimer, Calli; O'Meara, Sarah; Dawson, Kevin J.; Campbell, Peter J.; McDermott, Ultan; Wedge, David C.] Wellcome Trust Sanger Inst, Hinxton, England.
   [Brewer, Daniel S.; Cooper, Colin S.] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England.
   [Brewer, Daniel S.; Cooper, Colin S.] Univ E Anglia, Dept Biol Sci, Norwich NR4 7TJ, Norfolk, England.
   [Kallio, Heini; Hognas, Gunilla; Annala, Math; Kivinummi, Kati; Nykter, Matti; Visakorpi, Tapio; Bova, G. S.] Univ Tampere, BioMediTech, Inst Biosci & Med Technol, FIN-33101 Tampere, Finland.
   [Isaacs, William] Johns Hopkins Univ, Baltimore, MD USA.
   [Emmert-Buck, Michael R.] NCI, Lab Pathol, NIH, Avoneaux Med Inst, Oxford, MD USA.
   [Foster, Christopher] Univ Liverpool, London, England.
   [Foster, Christopher] HCA Pathol Labs, London, England.
   [Kote-Jarai, Zsofia; Cooper, Colin S.; Eeles, Rosalind A.] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England.
   [Easton, Douglas] Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
   [Whitaker, Hayley C.; Neal, David E.] Canc Res UK Cambridge Res Inst, Urooncol Res Grp, Cambridge, England.
   [Eeles, Rosalind A.] Royal Marsden NHS Fdn Trust, Sutton, Surrey, England.
NR 0
TC 0
Z9 0
U1 5
U2 5
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 956
DI 10.1158/1538-7445.AM2015-956
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502004
ER

PT J
AU Harenza, JL
   Parikh, HM
   Wei, JS
   Wen, XY
   Sindiri, S
   Patidar, R
   Salit, M
   Meltzer, PS
   Khan, J
   Zook, J
AF Harenza, Jo Lynne
   Parikh, Hemang M.
   Wei, Jun S.
   Wen, Xinyu
   Sindiri, Sivasish
   Patidar, Rajesh
   Salit, Marc
   Meltzer, Paul S.
   Khan, Javed
   Zook, Justin
TI Use of the SVClassify algorithm to classify pediatric solid tumor
   translocation variant calls as likely true or false positives
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Harenza, Jo Lynne] NIST, Appl Genet Grp, Gaithersburg, MD 20899 USA.
   [Parikh, Hemang M.; Salit, Marc; Zook, Justin] NIST, Genome Scale Measurements Grp, Gaithersburg, MD 20899 USA.
   [Wei, Jun S.; Wen, Xinyu; Sindiri, Sivasish; Patidar, Rajesh; Khan, Javed] NCI, Oncogen Sect, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Meltzer, Paul S.] NCI, Mol Genet Sect, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1077
DI 10.1158/1538-7445.AM2015-1077
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502120
ER

PT J
AU Haznadar, M
   Cai, QY
   Krausz, KW
   Bowman, ED
   Blot, WJ
   Gonzalez, FJ
   Harris, CC
AF Haznadar, Majda
   Cai, Qiuyin
   Krausz, Kristopher W.
   Bowman, Elise D.
   Blot, William J.
   Gonzalez, Frank J.
   Harris, Curtis C.
TI Lung cancer metabolomics identifies metabolites as robust risk
   biomarkers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Haznadar, Majda; Krausz, Kristopher W.; Bowman, Elise D.; Gonzalez, Frank J.; Harris, Curtis C.] NCI, Bethesda, MD 20892 USA.
   [Cai, Qiuyin; Blot, William J.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 935
DI 10.1158/1538-7445.AM2015-935
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501386
ER

PT J
AU He, JT
   Schepmoes, A
   Rastogi, A
   Tan, SH
   Yan, WS
   Huang, W
   Banerjee, S
   Shi, TJ
   Wu, CC
   Fillmore, T
   Gao, YQ
   Kagan, J
   Srivastava, S
   Smith, R
   Qian, WJ
   McLeod, D
   Petrovics, G
   Dobi, A
   Srinivasan, A
   Srivastava, S
   Rodland, K
   Liu, T
   Camp, D
AF He, Jintang
   Schepmoes, Athena
   Rastogi, Anshu
   Tan, Shyh-Han
   Yan, Wusheng
   Huang, Wei
   Banerjee, Sreedatta
   Shi, Tujin
   Wu, Chaochao
   Fillmore, Thomas
   Gao, Yuqian
   Kagan, Jacob
   Srivastava, Sudhir
   Smith, Richard
   Qian, Wei-Jun
   McLeod, David
   Petrovics, Gyorgy
   Dobi, Albert
   Srinivasan, Alagarsamy
   Srivastava, Shiv
   Rodland, Karin
   Liu, Tao
   Camp, David
TI Analytical platform evaluation for quantification of ERG oncoprotein in
   prostate cancer using protein and mRNA detection methods
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [He, Jintang; Schepmoes, Athena; Shi, Tujin; Wu, Chaochao; Fillmore, Thomas; Gao, Yuqian; Smith, Richard; Qian, Wei-Jun; Rodland, Karin; Liu, Tao; Camp, David] Pacific NW Natl Lab, Richland, WA 99352 USA.
   [Rastogi, Anshu; Tan, Shyh-Han; Yan, Wusheng; Huang, Wei; Banerjee, Sreedatta; Petrovics, Gyorgy; Dobi, Albert; Srinivasan, Alagarsamy; Srivastava, Shiv] Ctr Prostate Dis Res, Bethesda, MD USA.
   [Kagan, Jacob; Srivastava, Sudhir] NCI, Bethesda, MD 20892 USA.
   [McLeod, David] Walter Reed Natl Mil Med Ctr, Ctr Prostate Dis Res, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1818
DI 10.1158/1538-7445.AM2015-1818
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503303
ER

PT J
AU Heitzeneder, S
   Shem, JF
   Khan, J
   Mackall, CL
AF Heitzeneder, Sabine
   Shem, John F.
   Khan, Javed
   Mackall, Crystal L.
TI Preferential expression of CD99 isoform variant 5 (CD99v005) in Ewing
   sarcoma compared to normal tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Heitzeneder, Sabine; Mackall, Crystal L.] NCI, NIH, Pediat Oncol Branch, Bethesda, MD 20892 USA.
   [Shem, John F.; Khan, Javed] NCI, NIH, Canc Genet Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1357
DI 10.1158/1538-7445.AM2015-1357
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502395
ER

PT J
AU Hofmann, JN
   Birmann, BM
   Teras, LR
   Wang, Y
   Albanes, D
   Baris, D
   Colditz, GA
   De Roos, AJ
   Giles, GG
   Morton, LM
   Hosgood, HD
   Lan, Q
   Landgren, O
   Liao, LM
   Pfeiffer, RM
   Rothman, N
   Weinstein, SJ
   Pollak, MN
   Neuhouser, ML
   Purdue, MP
AF Hofmann, Jonathan N.
   Birmann, Brenda M.
   Teras, Lauren R.
   Wang, Ye
   Albanes, Demetrius
   Baris, Dalsu
   Colditz, Graham A.
   De Roos, Anneclaire J.
   Giles, Graham G.
   Morton, Lindsay M.
   Hosgood, H. Dean
   Lan, Qing
   Landgren, Ola
   Liao, Linda M.
   Pfeiffer, Ruth M.
   Rothman, Nathaniel
   Weinstein, Stephanie J.
   Pollak, Michael N.
   Neuhouser, Marian L.
   Purdue, Mark P.
TI A pooled investigation of circulating adiponectin levels and risk of
   multiple myeloma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Hofmann, Jonathan N.; Albanes, Demetrius; Baris, Dalsu; Morton, Lindsay M.; Lan, Qing; Liao, Linda M.; Pfeiffer, Ruth M.; Rothman, Nathaniel; Weinstein, Stephanie J.] NCI, DCEG, Bethesda, MD 20892 USA.
   [Birmann, Brenda M.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Teras, Lauren R.] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Wang, Ye; Pollak, Michael N.] McGill Univ, Montreal, PQ, Canada.
   [Wang, Ye; Pollak, Michael N.] McGill Univ, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada.
   [Colditz, Graham A.] Washington Univ, Sch Med, St Louis, MO USA.
   [Colditz, Graham A.] Barnes Jewish Hosp, St Louis, MO 63110 USA.
   [De Roos, Anneclaire J.] Drexel Univ, Philadelphia, PA 19104 USA.
   [Giles, Graham G.] Canc Council Victoria, Melbourne, Vic, Australia.
   [Hosgood, H. Dean] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Landgren, Ola] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Neuhouser, Marian L.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Purdue, Mark P.] Ontario Inst Canc Res, Toronto, ON, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 934
DI 10.1158/1538-7445.AM2015-934
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501385
ER

PT J
AU House, C
   Grajales, V
   Wubneh, H
   Kimble, D
   Kim, M
   Annunziata, C
AF House, Carrie
   Grajales, Valentina
   Wubneh, Helmae
   Kimble, Danielle
   Kim, Marianne
   Annunziata, Christina
TI IKK epsilon maintains MEK activation and suppresses non-canonical
   NF-kappa B signaling in triple-negative breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [House, Carrie; Grajales, Valentina; Wubneh, Helmae; Kimble, Danielle; Kim, Marianne; Annunziata, Christina] NCI, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1955
DI 10.1158/1538-7445.AM2015-1955
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504064
ER

PT J
AU Hsu, I
   Railkar, R
   Li, QT
   Agarwal, P
AF Hsu, Iawen
   Railkar, Reema
   Li, Quentin
   Agarwal, Piyush
TI Y chromosome genes contribute to higher male bladder cancer incidence
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Hsu, Iawen; Railkar, Reema; Li, Quentin; Agarwal, Piyush] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 109
DI 10.1158/1538-7445.AM2015-109
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500102
ER

PT J
AU Hu, W
   Zhang, LP
   Kim, C
   Tang, XJ
   Kim, S
   Bassig, B
   Seow, WJ
   Shen, M
   Qiu, CY
   Ge, YC
   Reiss, B
   Purdue, M
   Moore, L
   Li, LY
   Yue, F
   Huang, HL
   Smith, MT
   Vermeulen, R
   Rothman, N
   Lan, Q
AF Hu, Wei
   Zhang, Luoping
   Kim, Christopher
   Tang, Xiaojiang
   Kim, Sungkyoon
   Bassig, Bryan
   Seow, Wei-Jie
   Shen, Min
   Qiu, Chuangyi
   Ge, Yechen
   Reiss, Boris
   Purdue, Mark
   Moore, Lee
   Li, Laiyu
   Yue, Fei
   Huang, Hanlin
   Smith, Martyn T.
   Vermeulen, Roel
   Rothman, Nathaniel
   Lan, Qing
TI Occupational exposure to trichloroethylene and LINE-1 methylation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Hu, Wei; Kim, Christopher; Bassig, Bryan; Seow, Wei-Jie; Shen, Min; Purdue, Mark; Moore, Lee; Rothman, Nathaniel; Lan, Qing] NCI DCEG, Bethesda, MD USA.
   [Zhang, Luoping; Smith, Martyn T.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
   [Tang, Xiaojiang; Qiu, Chuangyi; Ge, Yechen; Li, Laiyu; Yue, Fei; Huang, Hanlin] Guangdong Poison Control Ctr, Guangzhou, Guangdong, Peoples R China.
   [Kim, Sungkyoon] Seoul Natl Univ, Dept Environm Hlth, Seoul, South Korea.
   [Reiss, Boris; Vermeulen, Roel] Univ Utrecht, Utrecht, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 840
DI 10.1158/1538-7445.AM2015-840
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501293
ER

PT J
AU Hu, Y
AF Hu, Yue
TI Genomic analysis of 207 rectal cancer samples
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Hu, Yue] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2169
DI 10.1158/1538-7445.AM2015-2169
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504274
ER

PT J
AU Inoue-Choi, M
   Sinha, R
   Gierach, GL
   Ward, MH
AF Inoue-Choi, Maki
   Sinha, Rashmi
   Gierach, Gretchen L.
   Ward, Mary H.
TI Dietary nitrate and nitrite, micronutrients, and postmenopausal breast
   cancer risk in the NIH-AARP Diet and Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Inoue-Choi, Maki; Sinha, Rashmi; Gierach, Gretchen L.; Ward, Mary H.] NCI, Rockville, MD USA.
RI Gierach, Gretchen/E-1817-2016
OI Gierach, Gretchen/0000-0002-0165-5522
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1883
DI 10.1158/1538-7445.AM2015-1883
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503368
ER

PT J
AU Irizarry-Caro, JA
   Ernst, M
   Court, C
   Rattray, A
   Bubunenko, M
   Jin, D
   Court, D
   Strathern, J
AF Irizarry-Caro, Jorge A.
   Ernst, Mary
   Court, Carolyn
   Rattray, Alison
   Bubunenko, Mikhail
   Jin, Ding
   Court, Donald
   Strathern, Jeffrey
TI Development of an assay to detect transcription misincorporation errors
   in Escherichia coli
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Irizarry-Caro, Jorge A.] NIAMSD, Bethesda, MD 20892 USA.
   [Ernst, Mary; Court, Carolyn; Rattray, Alison; Bubunenko, Mikhail; Jin, Ding; Court, Donald; Strathern, Jeffrey] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2219
DI 10.1158/1538-7445.AM2015-2219
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504324
ER

PT J
AU Jang, H
   Abraham, SJ
   Chavan, TS
   Hitchinson, B
   Khavrutskii, L
   Tarasova, NI
   Nussinov, R
   Gaponenko, V
AF Jang, Hyunbum
   Abraham, Sherwin J.
   Chavan, Tanmay S.
   Hitchinson, Ben
   Khavrutskii, Lyuba
   Tarasova, Nadya I.
   Nussinov, Ruth
   Gaponenko, Vadim
TI Mechanisms of membrane binding of K-Ras4B farnesylated hypervariable
   region
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Jang, Hyunbum; Khavrutskii, Lyuba; Tarasova, Nadya I.; Nussinov, Ruth] NCI, Frederick, MD 21701 USA.
   [Abraham, Sherwin J.; Chavan, Tanmay S.] Stanford Univ, Stanford, CA 94305 USA.
   [Hitchinson, Ben; Gaponenko, Vadim] Univ Illinois, Chicago, IL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2457
DI 10.1158/1538-7445.AM2015-2457
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505058
ER

PT J
AU Kang, ZG
   Goldstein, DS
   Yu, YK
   Meltzer, PS
   Loeb, DM
   Gao, L
AF Kang, Zhigang
   Goldstein, D. Seth
   Yu, Yunkai
   Meltzer, Paul S.
   Loeb, David M.
   Gao, Liang
TI Caspase-8 expression is predictive of tumor response to death receptor 5
   agonist antibody conatumumab in Ewing's sarcoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kang, Zhigang; Yu, Yunkai; Meltzer, Paul S.; Gao, Liang] NCI, Bethesda, MD 20892 USA.
   [Goldstein, D. Seth; Loeb, David M.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2917
DI 10.1158/1538-7445.AM2015-2917
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506063
ER

PT J
AU Kang, ZG
   Shah, A
   Yu, YK
   Zhu, YL
   Bhagat, AA
   Zhao, K
   Wu, A
   Gao, J
   Madan, R
   Gulley, J
   Dahut, W
   Meltzer, P
   Cao, L
AF Kang, Zhigang
   Shah, Avani
   Yu, Yunkai
   Zhu, Yuelin
   Bhagat, Ali Asgar
   Zhao, Kyra
   Wu, Andrew
   Gao, James
   Madan, Ravi
   Gulley, James
   Dahut, William
   Meltzer, Paul
   Cao, Liang
TI A novel transcript variant of androgen receptor identified in
   circulating tumor cells from castration-resistant prostate cancer
   patients as a potentially prognostic biomarker
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kang, Zhigang; Shah, Avani; Yu, Yunkai; Zhu, Yuelin; Gao, James; Madan, Ravi; Gulley, James; Dahut, William; Meltzer, Paul; Cao, Liang] NCI, Bethesda, MD 20892 USA.
   [Bhagat, Ali Asgar; Wu, Andrew] Clearbridge BioMed, Singapore, Singapore.
   [Zhao, Kyra] Clearbridge BioMed, Bethesda, Singapore.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 366
DI 10.1158/1538-7445.AM2015-366
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500347
ER

PT J
AU Katsube, R
   Noma, K
   Watanabe, S
   Urano, S
   Ninomiya, T
   Ohara, T
   Tazawa, H
   Kagawa, S
   Kobayashi, H
   Fujiwara, T
AF Katsube, Ryoichi
   Noma, Kazuhiro
   Watanabe, Shinichiro
   Urano, Shinichi
   Ninomiya, Takayuki
   Ohara, Toshiaki
   Tazawa, Hiroshi
   Kagawa, Shunsuke
   Kobayashi, Hisataka
   Fujiwara, Toshiyoshi
TI A novel photoimmunotherapy targeting cancer-associated fibroblasts
   (CAFs) overcomes therapeutic resistance in human esophageal cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Katsube, Ryoichi; Noma, Kazuhiro; Watanabe, Shinichiro; Urano, Shinichi; Ninomiya, Takayuki; Ohara, Toshiaki; Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, Toshiyoshi] Okayama Univ, Okayama 7008530, Japan.
   [Kobayashi, Hisataka] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 401
DI 10.1158/1538-7445.AM2015-401
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500381
ER

PT J
AU Kim, JH
   Kim, T
   Qu, A
   Gonzalez, FJ
AF Kim, Jung-Hwan
   Kim, Taehyeong
   Qu, Aijuan
   Gonzalez, Frank J.
TI Nuclear receptor PPAR alpha activation triggers hepatic cell death in
   Ikk beta-deficient mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kim, Jung-Hwan] Gyeongsang Natl Univ, Jinju, South Korea.
   [Kim, Taehyeong; Qu, Aijuan; Gonzalez, Frank J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 23
DI 10.1158/1538-7445.AM2015-23
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500022
ER

PT J
AU Kinyamu, HK
   Yang, J
   Bennett, B
   Grimm, S
   Bushel, P
   Archer, T
AF Kinyamu, Harriet K.
   Yang, Jun
   Bennett, Brian
   Grimm, Sara
   Bushel, Pierre
   Archer, Trevor
TI LIN28 gene targets are key mediators of breast cancer disease processes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kinyamu, Harriet K.; Yang, Jun; Bennett, Brian; Grimm, Sara; Bushel, Pierre; Archer, Trevor] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1972
DI 10.1158/1538-7445.AM2015-1972
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504081
ER

PT J
AU Kuhn, E
   Whiteaker, JR
   Martinez, M
   Holderfield, M
   Kennedy, J
   Jaffe, J
   Yan, P
   Lin, CW
   Whiteley, G
   Carr, SA
   Paulovich, AG
   Koomen, JM
AF Kuhn, Eric
   Whiteaker, Jeffrey R.
   Martinez, Melissa
   Holderfield, Matthew
   Kennedy, Jacob
   Jaffe, Jacob
   Yan, Ping
   Lin, ChenWei
   Whiteley, Gordon
   Carr, Steven A.
   Paulovich, Amanda G.
   Koomen, John M.
TI Assembling test points for quantitative proteomics to elucidate RAS
   signaling
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kuhn, Eric; Jaffe, Jacob; Carr, Steven A.] Broad Inst, Cambridge, MA USA.
   [Whiteaker, Jeffrey R.; Kennedy, Jacob; Yan, Ping; Lin, ChenWei; Paulovich, Amanda G.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Martinez, Melissa; Koomen, John M.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
   [Holderfield, Matthew; Whiteley, Gordon] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2002
DI 10.1158/1538-7445.AM2015-2002
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504109
ER

PT J
AU Kwilas, AR
   Ardiani, A
   Gameiro, SR
   Hodge, JW
AF Kwilas, Anna R.
   Ardiani, Andressa
   Gameiro, Sofia R.
   Hodge, James W.
TI Endocrine deprivation therapy increases the sensitivity of breast cancer
   cells to T cell-mediated lysis independently of estrogen receptor or
   androgen receptor status
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Kwilas, Anna R.; Ardiani, Andressa; Gameiro, Sofia R.; Hodge, James W.] NIH, Bethesda, MD 20892 USA.
RI Hodge, James/D-5518-2015
OI Hodge, James/0000-0001-5282-3154
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1341
DI 10.1158/1538-7445.AM2015-1341
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502379
ER

PT J
AU Lan, Q
   Seow, WJ
   Zhang, LP
   Vermeulen, RL
   Tang, XJ
   Hu, W
   Bassig, BA
   Ji, ZY
   Shiels, MS
   Kemp, TJ
   Shen, M
   Qiu, CY
   Reiss, B
   Freeman, LB
   Blair, A
   Kim, C
   Guo, WH
   Wen, CJ
   Li, LY
   Pinto, LA
   Huang, HL
   Smith, MT
   Hildesheim, A
   Rothman, N
AF Lan, Qing
   Seow, Wei Jie
   Zhang, Luoping
   Vermeulen, Roe L.
   Tang, Xiaojiang
   Hu, Wei
   Bassig, Bryan A.
   Ji, Zhiying
   Shiels, Meredith S.
   Kemp, Troy J.
   Shen, Min
   Qiu, Chuangyi
   Reiss, Boris
   Freeman, Laura Beane
   Blair, Aaron
   Kim, Christopher
   Guo, Weihong
   Wen, Cuiju
   Li, Laiyu
   Pinto, Ligia A.
   Huang, Hanlin
   Smith, Martyn T.
   Hildesheim, Allan
   Rothman, Nathaniel
TI Circulating immune/inflammation markers in Chinese workers
   occupationally exposed to formaldehyde
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lan, Qing; Seow, Wei Jie; Hu, Wei; Bassig, Bryan A.; Shiels, Meredith S.; Shen, Min; Freeman, Laura Beane; Blair, Aaron; Kim, Christopher; Wen, Cuiju; Hildesheim, Allan; Rothman, Nathaniel] NCI, Rockville, MD USA.
   [Zhang, Luoping; Ji, Zhiying; Guo, Weihong; Smith, Martyn T.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
   [Vermeulen, Roe L.; Reiss, Boris] Univ Utrecht, NL-3508 TC Utrecht, Netherlands.
   [Tang, Xiaojiang; Qiu, Chuangyi; Li, Laiyu; Huang, Hanlin] Guangdong Poison Control Ctr, Guangzhou, Guangdong, Peoples R China.
   [Kemp, Troy J.; Pinto, Ligia A.] Frederick Natl Lab Canc Res, Frederick, MD USA.
RI Beane Freeman, Laura/C-4468-2015
OI Beane Freeman, Laura/0000-0003-1294-4124
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 829
DI 10.1158/1538-7445.AM2015-829
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501282
ER

PT J
AU Lee, J
   Yan, WS
   Young, D
   Song, YJ
   Chen, YM
   Katta, S
   Mohamed, A
   Ravindranath, L
   Srinivasan, A
   Cullen, J
   Kagan, J
   Srivastava, S
   Dobi, A
   Rosner, I
   McLeod, DG
   Sesterhenn, IA
   Srivastava, S
   Petrovics, G
AF Lee, Jocelyn
   Yan, Wusheng
   Young, Denise
   Song, Yingjie
   Chen, Yongmei
   Katta, Shilpa
   Mohamed, Ahmed
   Ravindranath, Lakshmi
   Srinivasan, Alagarsamy
   Cullen, Jennifer
   Kagan, Jacob
   Srivastava, Sudhir
   Dobi, Albert
   Rosner, Inger
   McLeod, David G.
   Sesterhenn, Isabell A.
   Srivastava, Shiv
   Petrovics, Gyorgy
TI Evaluation of prostate cancer biomarkers and therapeutic targets in FFPE
   specimens using the NanoString platform
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lee, Jocelyn; Yan, Wusheng; Young, Denise; Song, Yingjie; Chen, Yongmei; Katta, Shilpa; Mohamed, Ahmed; Ravindranath, Lakshmi; Srinivasan, Alagarsamy; Cullen, Jennifer; Dobi, Albert; Rosner, Inger; McLeod, David G.; Sesterhenn, Isabell A.; Srivastava, Shiv; Petrovics, Gyorgy] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA.
   [Kagan, Jacob; Srivastava, Sudhir] NCI, Canc Biomarkers Res Grp, Canc Prevent Div, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2016
DI 10.1158/1538-7445.AM2015-2016
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504123
ER

PT J
AU Lee, M
   Williams, KA
   Hu, Y
   Andreas, J
   Patel, SJ
   Zhang, SY
   Crawford, NPS
AF Lee, Minnkyong
   Williams, Kendra A.
   Hu, Ying
   Andreas, Jonathan
   Patel, Shashankkumar J.
   Zhang, Suiyuan
   Crawford, Nigel P. S.
TI DLGAP5, MAT1A, SKA3, and ZMYM5 are novel susceptibility genes for
   aggressive prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lee, Minnkyong; Williams, Kendra A.; Andreas, Jonathan; Patel, Shashankkumar J.; Zhang, Suiyuan; Crawford, Nigel P. S.] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Hu, Ying] NCI, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2261
DI 10.1158/1538-7445.AM2015-2261
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504364
ER

PT J
AU Lee, YH
   Wong, TK
   Apolo, AB
   Agarwal, PK
   Bottaro, DP
AF Lee, Young H.
   Wong, Tiffany K.
   Apolo, Andrea B.
   Agarwal, Piyush K.
   Bottaro, Donald P.
TI Oncogenic signaling by MET and other cabozantinib targets in cells
   derived from urothelial carcinoma of the bladder
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lee, Young H.; Wong, Tiffany K.; Apolo, Andrea B.; Agarwal, Piyush K.; Bottaro, Donald P.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 140
DI 10.1158/1538-7445.AM2015-140
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500132
ER

PT J
AU Lepone, LM
   Donahue, RN
   Farsaci, B
   Grenga, I
   Boyerinas, B
   Jochems, C
   Tsang, KY
   Heery, CR
   Madan, RA
   Coyne, GO
   Singh, H
   Gulley, JL
   Schlom, J
AF Lepone, Lauren M.
   Donahue, Renee N.
   Farsaci, Benedetto
   Grenga, Italia
   Boyerinas, Benjamin
   Jochems, Caroline
   Tsang, Kwong-Yok
   Heery, Christopher R.
   Madan, Ravi A.
   Coyne, Geraldine O'Sullivan
   Singh, Harpreet
   Gulley, James L.
   Schlom, Jeffrey
TI Evaluation of immune cell subsets of cancer patients treated with a
   fully human IgG1 anti-PD-L1 MAb (MSB0010718C) capable of mediating ADCC
   of human tumor cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lepone, Lauren M.; Donahue, Renee N.; Farsaci, Benedetto; Grenga, Italia; Boyerinas, Benjamin; Jochems, Caroline; Tsang, Kwong-Yok; Heery, Christopher R.; Madan, Ravi A.; Coyne, Geraldine O'Sullivan; Singh, Harpreet; Gulley, James L.; Schlom, Jeffrey] NCI, NIH, Bethesda, MD 20892 USA.
RI Farsaci, Benedetto/L-9837-2014; Gulley, James/K-4139-2016
OI Farsaci, Benedetto/0000-0001-8275-2561; Gulley,
   James/0000-0002-6569-2912
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1316
DI 10.1158/1538-7445.AM2015-1316
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502354
ER

PT J
AU Liu, YN
   Lou, GH
   Norton, J
   Wang, C
   Kandela, I
   Tang, S
   Huang, M
   Avram, M
   Green, R
   Mazar, A
   Appella, D
   Chen, Z
   Huang, S
AF Liu, Yanning
   Lou, Guohua
   Norton, John
   Wang, Chen
   Kandela, Irawati
   Tang, Shuai
   Huang, Min
   Avram, Michael
   Green, Richard
   Mazar, Andrew
   Appella, Daniel
   Chen, Zhi
   Huang, Sui
TI 6-Methoxyethylamino-numonafide (MEAN) inhibits hepatocellular carcinoma
   as a single agent or in combination with sorafenib
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Liu, Yanning; Lou, Guohua; Chen, Zhi] Zhejiang Univ, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Norton, John; Wang, Chen; Avram, Michael; Green, Richard; Huang, Sui] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Kandela, Irawati; Mazar, Andrew] Northwestern Univ, Chicago, IL 60611 USA.
   [Tang, Shuai; Huang, Min] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China.
   [Appella, Daniel] NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1752
DI 10.1158/1538-7445.AM2015-1752
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503237
ER

PT J
AU Lofffield, E
   Shiels, MS
   Graubard, BI
   Katki, HA
   Chaturvedi, A
   Trabert, B
   Pinto, L
   Kemp, T
   Shebi, FM
   Mayne, ST
   Wentzensen, N
   Purdue, MP
   Hildesheim, A
   Sinha, R
   Freedman, ND
AF Lofffield, Erikka
   Shiels, Meredith S.
   Graubard, Barry I.
   Katki, Hormuzd A.
   Chaturvedi, Anil
   Trabert, Britton
   Pinto, Ligia
   Kemp, Troy
   Shebi, Fatma M.
   Mayne, Susan T.
   Wentzensen, Nicolas
   Purdue, Mark P.
   Hildesheim, Allan
   Sinha, Rashmi
   Freedman, Neal D.
TI Associations of coffee drinking with systemic immune and inflammatory
   markers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lofffield, Erikka; Shiels, Meredith S.; Graubard, Barry I.; Katki, Hormuzd A.; Chaturvedi, Anil; Trabert, Britton; Wentzensen, Nicolas; Hildesheim, Allan; Sinha, Rashmi; Freedman, Neal D.] NCI, Rockville, MD USA.
   [Pinto, Ligia; Kemp, Troy] Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Shebi, Fatma M.; Mayne, Susan T.] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
   [Purdue, Mark P.] Ontario Inst Canc Res, Toronto, ON, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1880
DI 10.1158/1538-7445.AM2015-1880
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503365
ER

PT J
AU Lu, D
   Harvey, M
   Madan, R
   Heery, C
   Marte, J
   Beasley, S
   Landers, M
   Krupa, R
   Louw, J
   Wahl, J
   Bales, N
   Marrinucci, D
   Schlom, J
   Gulley, J
   Dittamore, R
AF Lu, David
   Harvey, Melissa
   Madan, Ravi
   Heery, Christopher
   Marte, Jennifer
   Beasley, Sharon
   Landers, Mark
   Krupa, Rachel
   Louw, Jessica
   Wahl, Justin
   Bales, Natalee
   Marrinucci, Dena
   Schlom, Jeffrey
   Gulley, James
   Dittamore, Ryan
TI Recovery and characterization of circulating tumor cells (CTCs) in
   cryopreserved metastatic castrate-resistant prostate cancer (mCRPC)
   patient samples
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Lu, David; Harvey, Melissa; Beasley, Sharon; Landers, Mark; Krupa, Rachel; Louw, Jessica; Wahl, Justin; Bales, Natalee; Marrinucci, Dena; Dittamore, Ryan] Ep Sci, San Diego, CA USA.
   [Madan, Ravi; Heery, Christopher; Marte, Jennifer; Schlom, Jeffrey; Gulley, James] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1586
DI 10.1158/1538-7445.AM2015-1586
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503079
ER

PT J
AU Maachani, UB
   Tandle, A
   Shankavaram, U
   Kramp, T
   Camphausen, KA
AF Maachani, Uday Bhanu
   Tandle, Anita
   Shankavaram, Uma
   Kramp, Tamalee
   Camphausen, Kevin A.
TI Modulation of MiR-21 signaling by MPS1 in human glioblastoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Maachani, Uday Bhanu; Tandle, Anita; Shankavaram, Uma; Kramp, Tamalee; Camphausen, Kevin A.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 190
DI 10.1158/1538-7445.AM2015-190
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500180
ER

PT J
AU Mai, PL
   Rosenberg, PS
   Peter, JA
   DeCastro, R
   Khincha, PP
   Loud, JT
   Bremer, R
   Savage, SA
AF Mai, Phuong L.
   Rosenberg, Philip S.
   Peter, June A.
   DeCastro, Rosamma
   Khincha, Payal P.
   Loud, Jennifer T.
   Bremer, Renee
   Savage, Sharon A.
TI Cumulative cancer risk in the NCI Li-Fraumeni Syndrome Cohort
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mai, Phuong L.; Rosenberg, Philip S.; Peter, June A.; DeCastro, Rosamma; Khincha, Payal P.; Loud, Jennifer T.; Bremer, Renee; Savage, Sharon A.] NCI, Rockville, MD USA.
RI Savage, Sharon/B-9747-2015
OI Savage, Sharon/0000-0001-6006-0740
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2749
DI 10.1158/1538-7445.AM2015-2749
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505335
ER

PT J
AU Majzner, RG
   Simon, JS
   Grosso, JF
   Martinez, D
   Pawel, B
   Santi-Vincini, M
   Merchant, MS
   Sorensen, P
   Mackall, CL
   Maris, JM
AF Majzner, Robbie G.
   Simon, Jason S.
   Grosso, Joseph F.
   Martinez, Daniel
   Pawel, Bruce
   Santi-Vincini, Mariarita
   Merchant, Melinda S.
   Sorensen, Poul
   Mackall, Crystal L.
   Maris, John M.
TI Assessment of PD-L1 expression and tumor-associated lymphocytes in
   pediatric cancer tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Majzner, Robbie G.; Merchant, Melinda S.; Mackall, Crystal L.] NCI, Bethesda, MD 20892 USA.
   [Simon, Jason S.; Grosso, Joseph F.] Bristol Myers Squibb Co, Princeton, NJ USA.
   [Martinez, Daniel; Pawel, Bruce; Santi-Vincini, Mariarita; Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Sorensen, Poul] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada.
NR 0
TC 1
Z9 2
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 249
DI 10.1158/1538-7445.AM2015-249
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500235
ER

PT J
AU Makarova-Rusher, OV
   Altekruse, SF
   McNeel, TS
   Graubard, BI
   Duffy, AG
   Ulahannan, SV
   Greten, TF
   McGlynn, KA
AF Makarova-Rusher, Oxana V.
   Altekruse, Sean F.
   McNeel, Timothy S.
   Graubard, Barry I.
   Duffy, Austin G.
   Ulahannan, Susanna V.
   Greten, Tim F.
   McGlynn, Katherine A.
TI Risk factors for hepatocellular carcinoma (HCC) by race/ethnicity in the
   United States
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Makarova-Rusher, Oxana V.; Duffy, Austin G.; Ulahannan, Susanna V.; Greten, Tim F.] NCI, CCR, Bathesda, MD USA.
   [Altekruse, Sean F.] NCI, DCCPS, Bathesda, MD USA.
   [McNeel, Timothy S.] IMS Inc, Calverton, MD USA.
   [Graubard, Barry I.; McGlynn, Katherine A.] NCI, DCEG, Bathesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 875
DI 10.1158/1538-7445.AM2015-875
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501327
ER

PT J
AU McAllister, FE
   Agarwal, R
   Nguyen, B
   Zhou, YY
   Roy, S
   Chelsky, D
   Guan, P
   Barcus, M
   Odeh, H
   Carithers, L
   Moore, H
AF McAllister, Fiona E.
   Agarwal, Rachana
   Nguyen, Bich
   Zhou, Yiyong
   Roy, Sushmita
   Chelsky, Daniel
   Guan, Ping
   Barcus, Mary
   Odeh, Hana
   Carithers, Lararsha
   Moore, Helen
TI FFPE preanalytical variables: Investigating the effect of delayed times
   to fixation on the proteome and phosphoproteome for FFPE kidney tumor
   samples and a comparison of tumor versus normal for matching FFPE and
   OCT frozen tissue
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [McAllister, Fiona E.; Nguyen, Bich; Zhou, Yiyong; Roy, Sushmita; Chelsky, Daniel] Capr Prote, Menlo Pk, CA USA.
   [Agarwal, Rachana; Barcus, Mary] Leidos Biomed Res Inc, Frederick, MD USA.
   [Guan, Ping; Odeh, Hana; Carithers, Lararsha; Moore, Helen] NCI, Biorepositories & Biospecimen Res Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1821
DI 10.1158/1538-7445.AM2015-1821
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503306
ER

PT J
AU McGlynn, KA
   Hagberg, K
   Chen, J
   Jick, S
   Sahasrabuddhe, VV
AF McGlynn, Katherine A.
   Hagberg, Katrina
   Chen, Jie
   Jick, Susan
   Sahasrabuddhe, Vikrant V.
TI Menopausal hormone therapy and risk of primary liver cancer in the UK
   Clinical Practice Research Datalink
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [McGlynn, Katherine A.; Chen, Jie; Sahasrabuddhe, Vikrant V.] NCI DCEG, Bethesda, MD USA.
   [Hagberg, Katrina] Boston Univ, Sch Publ Hlth, Boston, MA USA.
   [Jick, Susan] Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 879
DI 10.1158/1538-7445.AM2015-879
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501331
ER

PT J
AU Meerzaman, D
   Finney, R
   Chen, QR
   Nguyen, C
   Hsu, CH
   Dunn, B
AF Meerzaman, Daoud
   Finney, Richard
   Chen, Qing-Rong
   Cu Nguyen
   Hsu, Chih Hao
   Dunn, Barbra
TI Alview (ALignment VIEWer): A software tool to visualize next generation
   sequencing (NGS) data
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Meerzaman, Daoud; Finney, Richard; Chen, Qing-Rong; Cu Nguyen; Hsu, Chih Hao; Dunn, Barbra] NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 63
DI 10.1158/1538-7445.AM2015-63
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500059
ER

PT J
AU Meier, JL
   Montgomery, DC
   Sorum, AW
   Kulkarni, RA
AF Meier, Jordan L.
   Montgomery, David C.
   Sorum, Alexander W.
   Kulkarni, Rhushikesh A.
TI Defining the metabolic regulation of epigenetics using chemical
   proteomics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Meier, Jordan L.; Montgomery, David C.; Sorum, Alexander W.; Kulkarni, Rhushikesh A.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 113
DI 10.1158/1538-7445.AM2015-113
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500106
ER

PT J
AU Mohammed, A
   Janakiram, NB
   Madka, V
   Brewer, M
   Ritchie, RL
   Lightfoot, S
   Kumar, G
   Sadeghi, M
   Patlolla, JMR
   Yamada, H
   Cruz-Monserrate, Z
   Houchen, CW
   Steele, VE
   Rao, CV
AF Mohammed, Altaf
   Janakiram, Naveena B.
   Madka, Venkateshwar
   Brewer, Misty
   Ritchie, Rebekah L.
   Lightfoot, Stan
   Kumar, Gaurav
   Sadeghi, Michael
   Patlolla, Jagan Mohan R.
   Yamada, Hiroshi
   Cruz-Monserrate, Zobeida
   Houchen, Courtney W.
   Steele, Vernon E.
   Rao, Chinthalapally V.
TI Targeting inflammation and pancreatitis blocks tumor-initiating stem
   cells and pancreatic cancer progression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mohammed, Altaf; Janakiram, Naveena B.; Madka, Venkateshwar; Brewer, Misty; Ritchie, Rebekah L.; Lightfoot, Stan; Kumar, Gaurav; Sadeghi, Michael; Patlolla, Jagan Mohan R.; Yamada, Hiroshi; Houchen, Courtney W.; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Cruz-Monserrate, Zobeida] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2819
DI 10.1158/1538-7445.AM2015-2819
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505402
ER

PT J
AU Mohammed, A
   Patlolla, JMR
   Zhang, YT
   Biddick, L
   Madka, V
   Li, Q
   Lightfoot, S
   Lubel, R
   Suen, CS
   Steele, VE
   Rao, CV
AF Mohammed, Altaf
   Patlolla, Jagan M. R.
   Zhang, Yuting
   Biddick, Laura
   Madka, Venkateshwar
   Li, Qian
   Lightfoot, Stan
   Lubel, Ronald
   Suen, Chen S.
   Steele, Vernon E.
   Rao, Chinthalapally V.
TI Omeprazole alone, or in combination with Aspirin inhibits
   azoxymethane-induced colon adenoma progression to adenocarcinoma and
   carcinoma invasion in F344 rat model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mohammed, Altaf; Patlolla, Jagan M. R.; Zhang, Yuting; Biddick, Laura; Madka, Venkateshwar; Li, Qian; Lightfoot, Stan; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Lubel, Ronald; Suen, Chen S.; Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2820
DI 10.1158/1538-7445.AM2015-2820
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505403
ER

PT J
AU Mondul, A
   Moore, S
   Sampson, J
   Weinstein, S
   Albanes, D
AF Mondul, Alison
   Moore, Steven
   Sampson, Joshua
   Weinstein, Stephanie
   Albanes, Demetrius
TI Serum lipid metabolites and alpha-ketoglutarate are inversely associated
   with aggressive prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mondul, Alison; Moore, Steven; Sampson, Joshua; Weinstein, Stephanie; Albanes, Demetrius] NCI, DCEG, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 936
DI 10.1158/1538-7445.AM2015-936
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501387
ER

PT J
AU Moshkovich, N
   Sato, M
   Tang, BW
   Yang, YA
   Flanders, KC
   Kadota, M
   Yang, H
   Lee, MP
   Wakefield, LM
AF Moshkovich, Nellie
   Sato, Misako
   Tang, Binwu
   Yang, Yu-an
   Flanders, Kathleen C.
   Kadota, Mitsutaka
   Yang, Howard
   Lee, Maxwell P.
   Wakefield, Lalage M.
TI Functional interactions between estrogen-related-receptor beta (ESRRB)
   and transforming growth factor-beta (TGF-beta) in the regulation of
   breast cancer stem cell dynamics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Moshkovich, Nellie; Sato, Misako; Tang, Binwu; Yang, Yu-an; Flanders, Kathleen C.; Yang, Howard; Lee, Maxwell P.; Wakefield, Lalage M.] NCI, Bethesda, MD 20892 USA.
   [Kadota, Mitsutaka] RIKEN Ctr Life Sci Technol, Kobe, Hyogo, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2244
DI 10.1158/1538-7445.AM2015-2244
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504347
ER

PT J
AU Moy, KA
   Potischman, N
   Thompson, FE
   Subar, A
   Ruder, EH
   Thiebaut, ACM
   Stolzenberg-Solomon, RZ
AF Moy, Kristin A.
   Potischman, Nancy
   Thompson, Frances E.
   Subar, Amy
   Ruder, Elizabeth H.
   Thiebaut, Anne C. M.
   Stolzenberg-Solomon, Rachael Z.
TI Adolescent and mid-life diet: risk of pancreatic cancer in the NIH-AARP
   Diet and Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Moy, Kristin A.; Potischman, Nancy; Thompson, Frances E.; Subar, Amy; Stolzenberg-Solomon, Rachael Z.] NCI, Rockville, MD USA.
   [Ruder, Elizabeth H.] Univ Pittsburgh, Pittsburgh, PA USA.
   [Thiebaut, Anne C. M.] Inst Pasteur, Unite Pharmacoepidemiol & Malad Infect, Paris, France.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1876
DI 10.1158/1538-7445.AM2015-1876
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503361
ER

PT J
AU Mullooly, M
   Yang, HP
   Falk, RT
   Nyante, S
   Cora, R
   Pfeiffer, RM
   Radisky, DC
   Visscher, DW
   Hartmann, LC
   Degnim, AC
   Stanczyk, FZ
   Figueroa, JF
   Garcia-Closas, M
   Lissowska, J
   Troester, MT
   Brinton, LA
   Sherman, ME
   Gierach, GL
AF Mullooly, Maeve
   Yang, Hannah P.
   Falk, Roni T.
   Nyante, Sarah
   Cora, Renata
   Pfeiffer, Ruth M.
   Radisky, Derek C.
   Visscher, Daniel W.
   Hartmann, Lynn C.
   Degnim, Amy C.
   Stanczyk, Frank Z.
   Figueroa, Jonine F.
   Garcia-Closas, Montserrat
   Lissowska, Jolanta
   Troester, Melissa T.
   Brinton, Louise A.
   Sherman, Mark E.
   Gierach, Gretchen L.
TI Investigation of the relationship between crown-like structures and
   adipose tissue hormone levels among postmenopausal women with breast
   cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Mullooly, Maeve; Yang, Hannah P.; Falk, Roni T.; Nyante, Sarah; Figueroa, Jonine F.; Brinton, Louise A.; Gierach, Gretchen L.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Mullooly, Maeve] NCI, Canc Prevent Fellowship Program, Canc Prevent Div, Bethesda, MD 20892 USA.
   [Cora, Renata] MB ASCP, CT ASCP, Stamford, CT USA.
   [Pfeiffer, Ruth M.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Radisky, Derek C.; Visscher, Daniel W.; Hartmann, Lynn C.; Degnim, Amy C.] Mayo Clin, Ctr Canc, Jacksonville, FL 32224 USA.
   [Stanczyk, Frank Z.] Univ So Calif, Keck Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA.
   [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England.
   [Lissowska, Jolanta] Ctr Canc, Dept Canc Epidemiol & Prevent, Warsaw, Poland.
   [Lissowska, Jolanta] M Sklodowska Curie Inst Oncol, Warsaw, Poland.
   [Troester, Melissa T.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
   [Troester, Melissa T.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
   [Sherman, Mark E.] NCI, Breast & Gynecol Canc Res Grp, Canc Prevent Div, Bethesda, MD 20892 USA.
RI Gierach, Gretchen/E-1817-2016
OI Gierach, Gretchen/0000-0002-0165-5522
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2767
DI 10.1158/1538-7445.AM2015-2767
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505353
ER

PT J
AU Murai, J
   Pommier, Y
AF Murai, Junko
   Pommier, Yves
TI The combination of the PARP inhibitor talazoparib (BMN 673) with the ATR
   inhibitor VE-821 overcomes the drug resistance of Schlafen 11-deficient
   cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Murai, Junko] Kyoto Univ, Kyoto, Japan.
   [Pommier, Yves] NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2849
DI 10.1158/1538-7445.AM2015-2849
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505432
ER

PT J
AU Murphy, B
   Yin, H
   Maris, JM
   Koib, AE
   Gorlick, R
   Reynolds, PC
   Kang, M
   Keir, ST
   Kurmasheva, R
   Dvorchik, I
   Wu, JR
   Billups, C
   Smith, MA
   Houghton, PJ
AF Murphy, Brendan
   Yin, Han
   Maris, John M.
   Koib, Anders E.
   Gorlick, Richard
   Reynolds, Patrick C.
   Kang, Min
   Keir, Stephen T.
   Kurmasheva, Raushan
   Dvorchik, Igor
   Wu, Jianrong
   Billups, Catherine
   Smith, Malcolm A.
   Houghton, Peter J.
TI Analysis of single mouse tumor response results from the Pediatric
   Preclinical Testing Program (PPTP)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Murphy, Brendan; Yin, Han; Keir, Stephen T.; Kurmasheva, Raushan; Dvorchik, Igor; Houghton, Peter J.] Nationwide Childrens Hosp, Ctr Childhood Canc, Columbus, OH USA.
   [Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Koib, Anders E.] Alfred I DuPont Hosp Children, Wilmington, DE USA.
   [Gorlick, Richard] Montefiore Med Ctr, Dept Pediat, Bronx, NY 10467 USA.
   [Reynolds, Patrick C.; Kang, Min] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Wu, Jianrong; Billups, Catherine] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Smith, Malcolm A.] NCI, CTEP, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1617
DI 10.1158/1538-7445.AM2015-1617
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503110
ER

PT J
AU Nickerson, ML
   Im, KM
   Turan, S
   Moore, LE
   Dean, M
   Theodorescu, D
AF Nickerson, Michael L.
   Im, Kate M.
   Turan, Sevilay
   Moore, Lee E.
   Dean, Michael
   Theodorescu, Dan
TI Clinical associations between altered bladder cancer genes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Nickerson, Michael L.; Turan, Sevilay; Dean, Michael] NCI, Frederick, MD 21701 USA.
   [Im, Kate M.] Data Sci Genom, Ellicott City, MD USA.
   [Moore, Lee E.] NCI, Rockville, MD USA.
   [Theodorescu, Dan] Univ Colorado, Aurora, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1105
DI 10.1158/1538-7445.AM2015-1105
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502147
ER

PT J
AU O'hayre, M
   Inoue, A
   Sales, K
   Kufareva, I
   Valera, JLC
   Guo, FK
   Mikelis, C
   DiPasquale, G
   Finkel, K
   Aoki, J
   Zheng, Y
   Bugge, TH
   Gutkind, JS
AF O'hayre, Morgan
   Inoue, Asuka
   Sales, Katiuchia
   Kufareva, Irina
   Valera, Juan Luis Callejas
   Guo, Fukun
   Mikelis, Constantinos
   DiPasquale, Giovanni
   Finkel, Kira
   Aoki, Junken
   Zheng, Yi
   Bugge, Thomas H.
   Gutkind, J. Silvio
TI Novel roles for GNA13 and RHOA as tumor suppressor genes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [O'hayre, Morgan; Sales, Katiuchia; Valera, Juan Luis Callejas; Mikelis, Constantinos; DiPasquale, Giovanni; Finkel, Kira; Bugge, Thomas H.; Gutkind, J. Silvio] NIH, Bethesda, MD 20892 USA.
   [Inoue, Asuka; Aoki, Junken] Tohoku Univ, Sendai, Miyagi 980, Japan.
   [Kufareva, Irina] Univ Calif San Diego, La Jolla, CA 92093 USA.
   [Guo, Fukun; Zheng, Yi] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2059
DI 10.1158/1538-7445.AM2015-2059
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504165
ER

PT J
AU Oldridge, DA
   Eleveld, TF
   Bernard, V
   Koster, J
   Daage, LC
   Diskin, SJ
   Schild, L
   Bentahar, NB
   Bellini, A
   Chicard, M
   Lapouble, E
   Combaret, V
   Legoix-Ne, P
   Michon, J
   Pugh, TJ
   Hart, LS
   Rader, J
   Attiyeh, EF
   Wei, JS
   Zhang, SL
   Naranjo, A
   Gastier-Foster, JM
   Hogarty, MD
   Smith, MA
   Auvil, JG
   Watkins, TBK
   Zwijnenburg, DA
   Ebus, ME
   van Sluis, P
   Hakkert, A
   van Wezel, E
   van der Schoot, CE
   Westerhout, EM
   Schulte, JH
   Tytgat, GA
   Dolman, MEM
   Janoueix-Lerosey, I
   Gerhard, DS
   Caron, HN
   Delattre, O
   Khan, J
   Versteeg, R
   Schleiermacher, G
   Maris, JM
   Molenaar, JJ
AF Oldridge, Derek A.
   Eleveld, Thomas F.
   Bernard, Virginie
   Koster, Jan
   Daage, Leo C.
   Diskin, Sharon J.
   Schild, Linda
   Bentahar, Nadia B.
   Bellini, Angela
   Chicard, Mathieu
   Lapouble, Eve
   Combaret, Valerie
   Legoix-Ne, Patricia
   Michon, Jean
   Pugh, Trevor J.
   Hart, Lori S.
   Rader, JulieAnn
   Attiyeh, Edward F.
   Wei, Jun S.
   Zhang, Shile
   Naranjo, Arlene
   Gastier-Foster, Julie M.
   Hogarty, Michael D.
   Smith, Malcolm A.
   Auvil, Jaime G.
   Watkins, Thomas B. K.
   Zwijnenburg, Danny A.
   Ebus, Marli E.
   van Sluis, Peter
   Hakkert, Anne
   van Wezel, Esther
   van der Schoot, C. Ellen
   Westerhout, Ellen M.
   Schulte, Johannes H.
   Tytgat, Godelieve A.
   Dolman, M. Emmy M.
   Janoueix-Lerosey, Isabelle
   Gerhard, Daniela S.
   Caron, Huib N.
   Delattre, Olivier
   Khan, Javed
   Versteeg, Rogier
   Schleiermacher, Gudrun
   Maris, John M.
   Molenaar, Jan J.
TI Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Oldridge, Derek A.; Diskin, Sharon J.; Hart, Lori S.; Rader, JulieAnn; Attiyeh, Edward F.; Hogarty, Michael D.; Maris, John M.] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA.
   [Oldridge, Derek A.; Diskin, Sharon J.; Hart, Lori S.; Rader, JulieAnn; Attiyeh, Edward F.; Hogarty, Michael D.; Maris, John M.] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA.
   [Eleveld, Thomas F.; Koster, Jan; Schild, Linda; Zwijnenburg, Danny A.; Ebus, Marli E.; van Sluis, Peter; Hakkert, Anne; Westerhout, Ellen M.; Dolman, M. Emmy M.; Versteeg, Rogier; Molenaar, Jan J.] Univ Amsterdam, Acad Med Ctr, Dept Oncogen, NL-1105 AZ Amsterdam, Netherlands.
   [Bernard, Virginie; Daage, Leo C.; Bentahar, Nadia B.; Legoix-Ne, Patricia] Inst Curie, Plateforme Sequencage ICGex, Paris, France.
   [Bellini, Angela; Chicard, Mathieu] Inst Curie, Lab SiRIC Rech Translat Oncol Pediat, Dept Transfert, Paris, France.
   [Lapouble, Eve] Inst Curie, Unite Genet Somat, Paris, France.
   [Combaret, Valerie] Ctr Leon Berard, Lab Oncol Mol, F-69373 Lyon, France.
   [Michon, Jean] Inst Curie, Dept Pediat, Paris, France.
   [Pugh, Trevor J.] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Pugh, Trevor J.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
   [Wei, Jun S.; Zhang, Shile; Smith, Malcolm A.; Auvil, Jaime G.; Gerhard, Daniela S.; Khan, Javed] NCI, Bethesda, MD 20892 USA.
   [Naranjo, Arlene] Univ Florida, Gainesville, FL USA.
   [Gastier-Foster, Julie M.] Nationwide Childrens Hosp, Columbus, OH USA.
   [Watkins, Thomas B. K.] Canc Res UK, Translat Canc Therapeut Lab, London, England.
   [van Wezel, Esther; van der Schoot, C. Ellen] Sanquin Res, Dept Expt Immunohematol, Amsterdam, Netherlands.
   [van Wezel, Esther; van der Schoot, C. Ellen] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
   [Schulte, Johannes H.] Childrens Hosp Essen, Dept Pediat Oncol & Haematol, Essen, Germany.
   [Tytgat, Godelieve A.; Caron, Huib N.] Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Oncol, NL-1105 AZ Amsterdam, Netherlands.
   [Janoueix-Lerosey, Isabelle; Delattre, Olivier; Schleiermacher, Gudrun] Inst Curie, Lab Genet & Biol Canc, INSERM U830, Paris, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2980
DI 10.1158/1538-7445.AM2015-2980
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506124
ER

PT J
AU Osgood, C
   Maloney, N
   Kidd, CG
   Gebregiorgis, M
   Nunez, LE
   Gonzalez-Sabin, J
   Helman, LJ
   Moris, F
   Grohar, PJ
AF Osgood, Christy
   Maloney, Nichole
   Kidd, Christopher G.
   Gebregiorgis, Meti
   Nunez, Luz E.
   Gonzalez-Sabin, Javier
   Helman, Lee J.
   Moris, Francisco
   Grohar, Patrick J.
TI Identification of mithramycin analogs with improved targeting of the
   EWS/FLI1 transcription factor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Osgood, Christy; Maloney, Nichole; Kidd, Christopher G.; Grohar, Patrick J.] Vanderbilt Univ, Nashville, TN 37235 USA.
   [Gebregiorgis, Meti; Helman, Lee J.] NCI, Bethesda, MD 20892 USA.
   [Nunez, Luz E.; Gonzalez-Sabin, Javier; Moris, Francisco] EntreChem Ls, Oviedo, Spain.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1612
DI 10.1158/1538-7445.AM2015-1612
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503105
ER

PT J
AU Pal, R
   Song, N
   Srinivasan, A
   Jacobs, SA
   Paik, S
   Pogue-Geile, KL
AF Pal, Rekha
   Song, Nan
   Srinivasan, Ashok
   Jacobs, Samuel A.
   Paik, Soonmyung
   Pogue-Geile, Katherine L.
TI Inflammatory and stem-like colorectal cell lines show differential
   response to MEK-162 and neratinib in combination
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pal, Rekha; Song, Nan; Srinivasan, Ashok; Jacobs, Samuel A.; Paik, Soonmyung; Pogue-Geile, Katherine L.] NSABP, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 706
DI 10.1158/1538-7445.AM2015-706
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501161
ER

PT J
AU Patel, S
   Sukumar, M
   Palmer, D
   Roychoudhari, R
   Roy, R
   Nussenzweig, A
   Restifo, N
AF Patel, Shashank
   Sukumar, Madhusudhanan
   Palmer, Douglas
   Roychoudhari, Rahul
   Roy, Rabindra
   Nussenzweig, Andre
   Restifo, Nicholas
TI Genomic stress in antigen experienced T-Iymphocytes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Patel, Shashank; Sukumar, Madhusudhanan; Palmer, Douglas; Roychoudhari, Rahul; Nussenzweig, Andre; Restifo, Nicholas] NCI, NIH, Bethesda, MD 20892 USA.
   [Roy, Rabindra] Georgetown Univ, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1347
DI 10.1158/1538-7445.AM2015-1347
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502385
ER

PT J
AU Pathak, A
   Seipel, K
   Pemov, A
   Dewan, R
   Brown, C
   Ravichandran, S
   Luke, BT
   Yeager, M
   Gatti, RA
   Caporaso, N
   Mulvihill, JJ
   Goldin, L
   Pabst, TM
   McMaster, ML
   Stewart, DR
AF Pathak, Anand
   Seipel, Katja
   Pemov, Alexander
   Dewan, Ramita
   Brown, Christina
   Ravichandran, Sarangan
   Luke, Brian T.
   Yeager, Meredith
   Gatti, Richard A.
   Caporaso, Neil
   Mulvihill, John J.
   Goldin, Lynn
   Pabst, Thomas Muller
   McMaster, Mary Lou
   Stewart, Douglas R.
TI Whole-exome sequencing reveals a novel germline variant in
   CEBPA-associated familial acute myeloid leukemia: 45-year follow-up of a
   large family
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Pathak, Anand; Pemov, Alexander; Dewan, Ramita; Caporaso, Neil; Goldin, Lynn; McMaster, Mary Lou; Stewart, Douglas R.] NIH, Bethesda, MD 20892 USA.
   [Seipel, Katja; Pabst, Thomas Muller] Univ Hosp Bern, CH-3010 Bern, Switzerland.
   [Seipel, Katja; Pabst, Thomas Muller] Univ Bern, Bern, Switzerland.
   [Brown, Christina; Gatti, Richard A.] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Ravichandran, Sarangan; Luke, Brian T.] NIH, Frederick, MD USA.
   [Yeager, Meredith] NIH, Rockville, MD USA.
   [Mulvihill, John J.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2756
DI 10.1158/1538-7445.AM2015-2756
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505342
ER

PT J
AU Rath, BH
   Wahba, A
   Camphausen, K
   Tofilon, P
AF Rath, Barbara Helen
   Wahba, Amy
   Camphausen, Kevin
   Tofilon, Philip
TI The normal brain microenvironment reduces the radiosensitivity of
   glioblastoma stem-like cells and identifies additional targets for
   radiosensitization
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Rath, Barbara Helen; Wahba, Amy; Camphausen, Kevin; Tofilon, Philip] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2390
DI 10.1158/1538-7445.AM2015-2390
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504489
ER

PT J
AU Richmond, J
   Evans, K
   Robbins, A
   Kurmasheva, RT
   Houghton, PJ
   Smith, MA
   Lock, RB
AF Richmond, Jennifer
   Evans, Kathryn
   Robbins, Alissa
   Kurmasheva, Raushan T.
   Houghton, Peter J.
   Smith, Malcolm A.
   Lock, Richard B.
TI In vivo and in vitro efficacy of birinapant in preclinical models of
   Ph-like pediatric acute lymphoblastic leukemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Richmond, Jennifer; Evans, Kathryn; Robbins, Alissa; Lock, Richard B.] Childrens Canc Inst, Randwick, NSW, Australia.
   [Kurmasheva, Raushan T.; Houghton, Peter J.] Nationwide Childrens Hosp, Ctr Childhood Canc, Columbus, OH USA.
   [Smith, Malcolm A.] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1620
DI 10.1158/1538-7445.AM2015-1620
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503113
ER

PT J
AU Russell, MR
   Penikis, A
   Oldridge, D
   Alvarez-Dominguez, JR
   McDaniel, L
   Diamond, M
   Padovan, O
   Raman, P
   Li, YM
   Wei, J
   Zhang, SL
   Gnanachandran, J
   Seeger, R
   Asgharzadeh, S
   Khan, J
   Diskin, S
   Maris, J
   Cole, K
AF Russell, Mike R.
   Penikis, Annalise
   Oldridge, Derek
   Alvarez-Dominguez, Juan R.
   McDaniel, Lee
   Diamond, Maura
   Padovan, Olivia
   Raman, Pichai
   Li, Yimei
   Wei, Jun
   Zhang, Shile
   Gnanachandran, Janahan
   Seeger, Robert
   Asgharzadeh, Shahab
   Khan, Javed
   Diskin, Sharon
   Maris, John
   Cole, Kristina
TI CASC15 is a tumor suppressor lncRNA at the 6p22 neuroblastoma
   susceptibility locus
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Russell, Mike R.; Penikis, Annalise; Oldridge, Derek; McDaniel, Lee; Diamond, Maura; Raman, Pichai; Li, Yimei; Diskin, Sharon; Maris, John; Cole, Kristina] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Alvarez-Dominguez, Juan R.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA.
   [Padovan, Olivia] Univ Penn, Philadelphia, PA 19104 USA.
   [Wei, Jun; Zhang, Shile; Khan, Javed] NCI, Bethesda, MD 20892 USA.
   [Gnanachandran, Janahan; Seeger, Robert; Asgharzadeh, Shahab] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 144
DI 10.1158/1538-7445.AM2015-144
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500136
ER

PT J
AU Saleh, A
   Cornelius, S
   Martin, S
   Ormanoglu, P
   Cheng, H
   Das, R
   Yang, XP
   Chen, Z
   Van Waes, C
AF Saleh, Anthony
   Cornelius, Shaleeka
   Martin, Scott
   Ormanoglu, Pinar
   Cheng, Hui
   Das, Rita
   Yang, Xinping
   Chen, Zhong
   Van Waes, Carter
TI Integrated functional RNAi screening and structural genomics identify
   inverse co-modulators of TP53 family and NF-kappa B transitional
   activation as potential therapeutic targets in head and neck squamous
   cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Saleh, Anthony; Cornelius, Shaleeka; Cheng, Hui; Das, Rita; Yang, Xinping; Chen, Zhong; Van Waes, Carter] NIDCD, NIH, Bethesda, MD USA.
   [Martin, Scott; Ormanoglu, Pinar] NCATS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1724
DI 10.1158/1538-7445.AM2015-1724
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503211
ER

PT J
AU Schonbach, M
   Danesh, A
   Bruce, J
   Woodburn, T
   Davidsen, T
   Hermida, L
   Gesuwan, P
   Auvil, JG
   Hampton, O
   Wheeler, D
   Gastier-Foster, J
   Smith, M
   Gerhard, D
   Maris, JM
   Reynolds, P
   Pugh, TJ
AF Schonbach, Maya
   Danesh, Arnavaz
   Bruce, Jeff
   Woodburn, Tito
   Davidsen, Tanja
   Hermida, Leandro
   Gesuwan, Patee
   Auvil, Jaime Guidry
   Hampton, Oliver
   Wheeler, David
   Gastier-Foster, Julie
   Smith, Malcolm
   Gerhard, Daniela
   Maris, John M.
   Reynolds, Patrick
   Pugh, Trevor J.
TI Fidelity of subclonal representation in human neuroblastoma-derived cell
   line and patient-derived xenograft models: A report from the NCI-TARGET
   project
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Schonbach, Maya; Danesh, Arnavaz; Bruce, Jeff; Pugh, Trevor J.] Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Woodburn, Tito; Reynolds, Patrick] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Davidsen, Tanja; Hermida, Leandro; Gesuwan, Patee; Auvil, Jaime Guidry; Smith, Malcolm; Gerhard, Daniela] NCI, Bethesda, MD 20892 USA.
   [Hampton, Oliver; Wheeler, David] Baylor Coll Med, Houston, TX 77030 USA.
   [Gastier-Foster, Julie] Nationwide Childrens Hosp, Columbus, OH USA.
   [Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 484
DI 10.1158/1538-7445.AM2015-484
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500461
ER

PT J
AU Schwentner, R
   Papamarkou, T
   Kauer, M
   Stathopoulos, V
   Yang, F
   Bilke, S
   Meltzer, PS
   Girolami, M
   Kovar, H
AF Schwentner, Raphaela
   Papamarkou, Theodore
   Kauer, Maximilian
   Stathopoulos, Vassilios
   Yang, Fan
   Bilke, Sven
   Meltzer, Paul S.
   Girolami, Mark
   Kovar, Heinrich
TI Evidence for E2F/EWS-FLI1 oncoprotein synergism using systems biology
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Schwentner, Raphaela; Kauer, Maximilian; Kovar, Heinrich] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria.
   [Papamarkou, Theodore; Stathopoulos, Vassilios; Girolami, Mark] Univ Warwick, Coventry CV4 7AL, W Midlands, England.
   [Yang, Fan; Bilke, Sven; Meltzer, Paul S.] NCI, Bethesda, MD 20892 USA.
RI Papamarkou, Theodore/A-2958-2012
OI Papamarkou, Theodore/0000-0002-9689-543X
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2104
DI 10.1158/1538-7445.AM2015-2104
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504209
ER

PT J
AU Scroggins, BT
   Burkeen, JF
   Chung, EJ
   White, AO
   Chung, SI
   Hudak, KE
   Citrin, DE
AF Scroggins, Bradley T.
   Burkeen, Jeffery F.
   Chung, Eun Joo
   White, Ayla O.
   Chung, Su I.
   Hudak, Kathryn E.
   Citrin, Deborah E.
TI Mithramycin A as a radiation sensitizer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Scroggins, Bradley T.; Burkeen, Jeffery F.; Chung, Eun Joo; White, Ayla O.; Chung, Su I.; Hudak, Kathryn E.; Citrin, Deborah E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1799
DI 10.1158/1538-7445.AM2015-1799
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503284
ER

PT J
AU Senkevitch, E
   Hixon, J
   Li, WQ
   Durum, S
AF Senkevitch, Emilee
   Hixon, Julie
   Li, Wenqing
   Durum, Scott
TI A model system to treat T-cell acute lymphoblastic leukemia with JAK
   inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Senkevitch, Emilee; Hixon, Julie; Li, Wenqing; Durum, Scott] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2287
DI 10.1158/1538-7445.AM2015-2287
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504390
ER

PT J
AU Seow, WJ
   Li, WQ
   Chapman, RS
   Hu, W
   Vermeulen, R
   He, XZ
   Bassig, BA
   Kim, C
   Rothman, N
   Lan, Q
AF Seow, Wei Jie
   Li, Wen-Qing
   Chapman, Robert S.
   Hu, Wei
   Vermeulen, Roel
   He, Xingzhou
   Bassig, Bryan A.
   Kim, Christopher
   Rothman, Nathaniel
   Lan, Qing
TI Household stove improvement and lung cancer mortality in Xuanwei, China:
   A 33-years' follow-up study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Seow, Wei Jie; Li, Wen-Qing; Hu, Wei; Bassig, Bryan A.; Kim, Christopher; Rothman, Nathaniel; Lan, Qing] NCI, Rockville, MD USA.
   [Chapman, Robert S.] Chulalongkorn Univ, Bangkok 10330, Thailand.
   [Vermeulen, Roel] Univ Utrecht, Utrecht, Netherlands.
   [He, Xingzhou] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 838
DI 10.1158/1538-7445.AM2015-838
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501291
ER

PT J
AU Sharma, K
   Beam, K
   Fer, N
   Holderfield, M
AF Sharma, Kanika
   Beam, Katie
   Fer, Nicole
   Holderfield, Matthew
TI Correlating RAS oncogenic allele dependence with drug sensitivity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sharma, Kanika; Beam, Katie; Fer, Nicole; Holderfield, Matthew] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2147
DI 10.1158/1538-7445.AM2015-2147
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504252
ER

PT J
AU Sheth, M
   Zhang, JS
   Zenklusen, JC
AF Sheth, Margi
   Zhang, Jiashan
   Zenklusen, Jean C.
TI A comprehensive guide for managing large-scale collaborative genomics
   research projects
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Sheth, Margi; Zhang, Jiashan; Zenklusen, Jean C.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1634
DI 10.1158/1538-7445.AM2015-1634
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503127
ER

PT J
AU Shimbo, T
   Lavender, C
   Grimm, SA
   Doi, MI
   Henriques, T
   Cannady, KR
   Murphy, KJ
   Gilchrist, DA
   Burkholder, A
   Hayes, JJ
   Adelman, K
   Archer, TK
   Zaret, KS
   Wade, PA
AF Shimbo, Takashi
   Lavender, Christopher
   Grimm, Sara A.
   Doi, Makiko I.
   Henriques, Telmo
   Cannady, Kimberly R.
   Murphy, Kevin J.
   Gilchrist, Daniel A.
   Burkholder, Adam
   Hayes, Jeffrey J.
   Adelman, Karen
   Archer, Trevor K.
   Zaret, Kenneth S.
   Wade, Paul A.
TI MBD3 regulates chromatin accessibility at active promoters
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Shimbo, Takashi; Lavender, Christopher; Grimm, Sara A.; Henriques, Telmo; Cannady, Kimberly R.; Gilchrist, Daniel A.; Burkholder, Adam; Adelman, Karen; Archer, Trevor K.; Wade, Paul A.] NIEHS, NIH, Res Triangle Pk, NC USA.
   [Doi, Makiko I.; Zaret, Kenneth S.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Murphy, Kevin J.; Hayes, Jeffrey J.] Univ Rochester, Dept Biochem & Biophys, Rochester, NY 14627 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2862
DI 10.1158/1538-7445.AM2015-2862
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506009
ER

PT J
AU Singh, NS
   Catazaro, J
   Bernier, M
   Powers, R
   Wainer, I
AF Singh, Nagendra S.
   Catazaro, Jonathan
   Bernier, Michel
   Powers, Robert
   Wainer, Irving
TI (R,R ')-4 '-Methoxy-1-naphthylfenoterol decreases glycolytic activity in
   the PANC-1 pancreatic cancer cell line
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Singh, Nagendra S.; Bernier, Michel] NIA, NIH, Baltimore, MD 21224 USA.
   [Catazaro, Jonathan; Powers, Robert] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA.
   [Wainer, Irving] Mitchell Woods Pharmaceut, Shelton, CT USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1172
DI 10.1158/1538-7445.AM2015-1172
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502214
ER

PT J
AU Skates, SJ
   Anderson, KS
   Liu, T
   Kulasingam, V
   Rabideau, D
   Wu, CC
   Gillette, M
   Godwin, AK
   Urban, N
   Lokshin, A
   Marks, J
   Diamandis, E
   Zhang, Z
   Srivastava, S
   Kagan, J
   Patriotis, C
   Rodland, K
AF Skates, Steven J.
   Anderson, Karen S.
   Liu, Tao
   Kulasingam, Vathany
   Rabideau, Dustin
   Wu, Chaochao
   Gillette, Michael
   Godwin, Andrew K.
   Urban, Nicole
   Lokshin, Anna
   Marks, Jeffrey
   Diamandis, Eleftherios
   Zhang, Zhen
   Srivastava, Sudhir
   Kagan, Jacob
   Patriotis, Christos
   Rodland, Karin
TI Early Detection Research Network (EDRN) validation of circulating
   ovarian cancer biomarkers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Skates, Steven J.; Rabideau, Dustin; Gillette, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Anderson, Karen S.] Arizona State Univ, Phoenix, AZ USA.
   [Liu, Tao; Wu, Chaochao; Rodland, Karin] Pacific NW Natl Lab, Richland, WA 99352 USA.
   [Kulasingam, Vathany; Diamandis, Eleftherios] Univ Toronto, Toronto, ON, Canada.
   [Gillette, Michael] Broad Inst, Cambridge, MA USA.
   [Godwin, Andrew K.] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA.
   [Urban, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Lokshin, Anna] Univ Pittsburgh, Pittsburgh, PA USA.
   [Marks, Jeffrey] Duke Univ, Durham, NC USA.
   [Zhang, Zhen] Johns Hopkins Univ, Baltimore, MD USA.
   [Srivastava, Sudhir; Kagan, Jacob; Patriotis, Christos] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1570
DI 10.1158/1538-7445.AM2015-1570
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503064
ER

PT J
AU Smith, MA
   Lock, R
   Carol, H
   Maris, JM
   Gorlick, R
   Kolb, EA
   Keir, ST
   Wu, JR
   Landesman, Y
   Shacham, S
   Lyalin, D
   Kurmasheva, RT
   Houghton, PJ
AF Smith, Malcolm A.
   Lock, Richard
   Carol, Hernan
   Maris, John M.
   Gorlick, Richard
   Kolb, E. Anders
   Keir, Stephen T.
   Wu, Jianrong
   Landesman, Yosef
   Shacham, Sharon
   Lyalin, Dmitry
   Kurmasheva, Raushan T.
   Houghton, Peter J.
TI Pharmacodynamic and genomic markers associated with response to the
   XPO1/CRM1 inhibitor selinexor (KPT-330): a report from the Pediatric
   Preclinical Testing Program
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Smith, Malcolm A.] NCI, Bethesda, MD 20892 USA.
   [Lock, Richard; Carol, Hernan] Childrens Canc Inst Australia Med Res, Randwick, NSW, Australia.
   [Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Gorlick, Richard] Childrens Hosp Montefiore, Bronx, NY USA.
   [Kolb, E. Anders] Alfred I DuPont Hosp Children, Wilmington, DE USA.
   [Keir, Stephen T.] Duke Univ, Med Ctr, Durham, NC USA.
   [Wu, Jianrong] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Landesman, Yosef; Shacham, Sharon] Karyopharm Therapeut, Newton, MA USA.
   [Lyalin, Dmitry; Kurmasheva, Raushan T.; Houghton, Peter J.] Nationwide Childrens Hosp, Columbus, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1616
DI 10.1158/1538-7445.AM2015-1616
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503109
ER

PT J
AU Smith, MA
   Kang, M
   Reynolds, PC
   Lock, RB
   Carol, H
   Gorlick, R
   Kolb, AE
   Maris, JM
   Keir, ST
   Billups, CA
   Kurmasheva, R
   Houghton, PJ
AF Smith, Malcolm A.
   Kang, Min
   Reynolds, Patrick C.
   Lock, Richard B.
   Carol, Hernan
   Gorlick, Richard
   Kolb, Anders E.
   Maris, John M.
   Keir, Stephen T.
   Billups, Catherine A.
   Kurmasheva, Raushan
   Houghton, Peter J.
TI Initial testing (stage 1) of the Curaxin, CBL0137, by the Pediatric
   Preclinical Testing Program (PPTP)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Smith, Malcolm A.] NCI, CTEP, Bethesda, MD 20892 USA.
   [Kang, Min; Reynolds, Patrick C.] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Lock, Richard B.; Carol, Hernan] Childrens Canc Inst, Randwick, NSW, Australia.
   [Gorlick, Richard] Montefiore Med Ctr, Dept Pediat, Bronx, NY 10467 USA.
   [Kolb, Anders E.] Alfred I DuPont Hosp Children, Wilmington, DE USA.
   [Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Keir, Stephen T.] Duke Univ, Med Ctr, Durham, NC USA.
   [Billups, Catherine A.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Kurmasheva, Raushan; Houghton, Peter J.] Nationwide Childrens Hosp, Ctr Childhood Canc, Columbus, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1615
DI 10.1158/1538-7445.AM2015-1615
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503108
ER

PT J
AU Song, JS
   Gonzales, NR
   Yamashita, RA
   Marchler-Bauer, A
   Bryant, SH
AF Song, James S.
   Gonzales, Noreen R.
   Yamashita, Roxanne A.
   Marchler-Bauer, Aron
   Bryant, Stephen H.
TI Evolutionary, structural, and functional insights into the
   seven-transmembrane GPCR superfamily through NCBI's Conserved Domain
   Database
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Song, James S.; Gonzales, Noreen R.; Yamashita, Roxanne A.; Marchler-Bauer, Aron; Bryant, Stephen H.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1090
DI 10.1158/1538-7445.AM2015-1090
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502132
ER

PT J
AU Song, NY
   Willette-Brown, J
   Dalta, M
   Hu, YL
AF Song, Na-Young
   Willette-Brown, Jami
   Dalta, Mahesh
   Hu, Yinling
TI IKK alpha at the crossroad between inflammation, oxidative stress and
   lung carcinogenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Song, Na-Young; Willette-Brown, Jami; Dalta, Mahesh; Hu, Yinling] NCI Frederick, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 801
DI 10.1158/1538-7445.AM2015-801
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501254
ER

PT J
AU Soto-Pantoja, DR
   Sipes, JM
   Morris, N
   Emmenaker, NJ
   Roberts, DD
AF Soto-Pantoja, David R.
   Sipes, John M.
   Morris, Nicole
   Emmenaker, Nancy J.
   Roberts, David D.
TI Thrombospondin-1 regulates energy metabolism to increase carcinogenesis
   in an in vivo model of colorectal cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Soto-Pantoja, David R.; Sipes, John M.; Roberts, David D.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Morris, Nicole] NCI, Lab Anim Sci Program, Bethesda, MD 20892 USA.
   [Emmenaker, Nancy J.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1202
DI 10.1158/1538-7445.AM2015-1202
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502242
ER

PT J
AU Spehalski, EI
   Saito, K
   Kramp, T
   Tandle, A
   Rath, B
   Cherukuri, M
   Camphausen, K
AF Spehalski, Elizabeth I.
   Saito, Keita
   Kramp, Tamalee
   Tandle, Anita
   Rath, Barbara
   Cherukuri, Murali
   Camphausen, Kevin
TI Exploiting glioma stem cell metabolism to abrogate radioresistance in
   glioblastomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Spehalski, Elizabeth I.; Saito, Keita; Kramp, Tamalee; Tandle, Anita; Rath, Barbara; Cherukuri, Murali; Camphausen, Kevin] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1174
DI 10.1158/1538-7445.AM2015-1174
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502216
ER

PT J
AU Takaku, M
   Grimm, SA
   Shimbo, T
   Perera, L
   Machida, S
   Kurumizaka, H
   Wade, PA
AF Takaku, Motoki
   Grimm, Sara A.
   Shimbo, Takashi
   Perera, Lalith
   Machida, Shinichi
   Kurumizaka, Hitoshi
   Wade, Paul A.
TI GATA3 modulates chromatin structure to establish active enhancers in
   breast cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Takaku, Motoki; Grimm, Sara A.; Shimbo, Takashi; Perera, Lalith; Wade, Paul A.] NIEHS, POB 12233, Res Triangle Pk, NC 27709 USA.
   [Machida, Shinichi; Kurumizaka, Hitoshi] Waseda Univ, Tokyo, Japan.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 964
DI 10.1158/1538-7445.AM2015-964
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502011
ER

PT J
AU Tang, BW
   Raviv, A
   Esposito, D
   Daniel, C
   Flanders, KC
   Yang, YA
   Wakefield, LM
AF Tang, Binwu
   Raviv, Asaf
   Esposito, Dominic
   Daniel, Catherine
   Flanders, Kathleen C.
   Yang, Yu-an
   Wakefield, Lalage M.
TI Transforming Growth Factor-beta (TGF-beta) directly regulates breast
   cancer stem cell dynamics in vitro and in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Tang, Binwu; Raviv, Asaf; Daniel, Catherine; Flanders, Kathleen C.; Yang, Yu-an; Wakefield, Lalage M.] NCI, Bethesda, MD 20892 USA.
   [Esposito, Dominic] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2221
DI 10.1158/1538-7445.AM2015-2221
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504326
ER

PT J
AU Tangrea, MA
   Rosenberg, AZ
   Fetsch, PA
   Armani, MD
   Xi, LQ
   Raffeld, M
   Pham, TT
   Chen, Y
   O'Flaherty, N
   Stussman, R
   Blackler, AR
   Du, Q
   Hanson, JC
   Roth, MJ
   Filie, AC
   Roh, MH
   Hipp, JD
   Emmert-Buck, MR
AF Tangrea, Michael A.
   Rosenberg, Avi Z.
   Fetsch, Patricia A.
   Armani, Michael D.
   Xi, Liqiang
   Raffeld, Mark
   Tina Thu Pham
   Chen, Yun
   O'Flaherty, Neil
   Stussman, Rebecca
   Blackler, Adele R.
   Du, Qiang
   Hanson, Jeffrey C.
   Roth, Mark J.
   Filie, Armando C.
   Roh, Michael H.
   Hipp, Jason D.
   Emmert-Buck, Michael R.
TI Do-It-Yourself expression microdissection (DIY xMD): A low-cost,
   high-throughput cell and organelle isolation system
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Tangrea, Michael A.] Sinai Hosp, Alvin & Lois Lapidus Canc Inst, 2401 W Belvedere Ave, Baltimore, MD 21215 USA.
   [Rosenberg, Avi Z.] Johns Hopkins Univ, Baltimore, MD USA.
   [Fetsch, Patricia A.; Armani, Michael D.; Xi, Liqiang; Raffeld, Mark; Tina Thu Pham; Chen, Yun; O'Flaherty, Neil; Stussman, Rebecca; Blackler, Adele R.; Du, Qiang; Hanson, Jeffrey C.; Roth, Mark J.; Filie, Armando C.; Hipp, Jason D.] NCI, NIH, Bethesda, MD 20892 USA.
   [Roh, Michael H.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Emmert-Buck, Michael R.] Avoneaux Med Inst, Oxford, MD USA.
OI Chen, Yun/0000-0001-6917-7814
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 230
DI 10.1158/1538-7445.AM2015-230
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500218
ER

PT J
AU Thiele, CJ
   Liu, ZH
   Veschi, V
   Buehler, E
   Martin, S
AF Thiele, Carol J.
   Liu, Zhihui
   Veschi, Veronica
   Buehler, Eugene
   Martin, Scott
TI Whole genome screen to identify genes targeting MYCN-driven embryonal
   tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Thiele, Carol J.; Liu, Zhihui; Veschi, Veronica] NCI, Bethesda, MD 20892 USA.
   [Buehler, Eugene; Martin, Scott] Natl Ctr Adv Translat Sci, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 487
DI 10.1158/1538-7445.AM2015-487
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578500464
ER

PT J
AU Tripathi, BK
   Qian, XL
   Grant, T
   Mertins, P
   Wang, DR
   Papageorge, AG
   Carr, SA
   Lowy, DR
AF Tripathi, Brajendra K.
   Qian, Xiaolan
   Grant, Tiera
   Mertins, Philipp
   Wang, Dunrui
   Papageorge, Alex G.
   Carr, Steven A.
   Lowy, Douglas R.
TI Inactivation of the tumor suppressor DLC1 by the oncogenes SRC and ERK1
   in lung adenocarcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Tripathi, Brajendra K.; Qian, Xiaolan; Grant, Tiera; Wang, Dunrui; Papageorge, Alex G.; Lowy, Douglas R.] NCI, NIH, Bethesda, MD 20892 USA.
   [Mertins, Philipp; Carr, Steven A.] Broad Inst MIT & Harvard, Cambridge, MA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2155
DI 10.1158/1538-7445.AM2015-2155
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578504260
ER

PT J
AU Vanpouille-Box, CI
   Aryankalayil, M
   Pilones, KA
   Formenti, SC
   Coleman, N
   Demaria, S
AF Vanpouille-Box, Claire Isabelle
   Aryankalayil, Molykutty
   Pilones, Karsten A.
   Formenti, Silvia C.
   Coleman, Norman
   Demaria, Sandra
TI Fractionated but not single dose radiation is an optimal adjuvant for in
   situ tumor vaccination
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Vanpouille-Box, Claire Isabelle; Pilones, Karsten A.; Formenti, Silvia C.; Demaria, Sandra] NYU, Sch Med, New York, NY USA.
   [Aryankalayil, Molykutty; Coleman, Norman] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
OI Vanpouille-Box, Claire/0000-0001-7213-0670
NR 0
TC 1
Z9 1
U1 1
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2493
DI 10.1158/1538-7445.AM2015-2493
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505086
ER

PT J
AU Wang, J
   He, PJ
   Gaida, MM
   Yang, SH
   Schetter, A
   Gaedcke, J
   Ghadimi, M
   Ried, T
   Yfantis, HG
   Lee, DH
   Weiss, JM
   Hanna, N
   Alexander, HR
   Hussain, SP
AF Wang, Jian
   He, Peijun
   Gaida, Matthias M.
   Yang, Shouhui
   Schetter, Aaron
   Gaedcke, Jochen
   Ghadimi, Michael
   Ried, Thomas
   Yfantis, Harris G.
   Lee, Dong H.
   Weiss, Jonathan M.
   Hanna, Nadar
   Alexander, H. Richard
   Hussain, S. Perwez
TI Nitric oxide signaling pathway as a pathogenic driver in pancreatic
   cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wang, Jian; He, Peijun; Yang, Shouhui; Schetter, Aaron; Ried, Thomas; Weiss, Jonathan M.; Hussain, S. Perwez] NCI, Bethesda, MD 20892 USA.
   [Gaida, Matthias M.] CCR, Bethesda, MD USA.
   [Yfantis, Harris G.; Lee, Dong H.] Baltimore Vet Affairs Med Ctr, Baltimore, MD USA.
   [Hanna, Nadar] Univ Maryland, Baltimore, MD 21201 USA.
   [Alexander, H. Richard] Univ Maryland, Sch Med, College Pk, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 923
DI 10.1158/1538-7445.AM2015-923
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501374
ER

PT J
AU Wang, Z
   Kanetsky, PA
   McGlynn, KA
   Bishop, DT
   Chung, CC
   Dalgaard, MD
   Grotmol, T
   Greene, MH
   Gupta, R
   Haugen, TB
   Litchfield, K
   Loud, JT
   Mitra, N
   Nielsen, K
   Turnbull, C
   Rajpert-DeMeyts, E
   Vardhanabhuti, S
   Wiklund, F
   Schwartz, S
   Chanock, SJ
   Nathanson, KL
AF Wang, Zhaoming
   Kanetsky, Peter A.
   McGlynn, Katherine A.
   Bishop, D. Timothy
   Chung, Charles C.
   Dalgaard, Marlene D.
   Grotmol, Tom
   Greene, Mark H.
   Gupta, Ramneek
   Haugen, Trine B.
   Litchfield, Kevin
   Loud, Jennifer T.
   Mitra, Nandita
   Nielsen, Kasper
   Turnbull, Clare
   Rajpert-DeMeyts, Ewa
   Vardhanabhuti, Saran
   Wiklund, Fredrik
   Schwartz, Stephen
   Chanock, Stephen J.
   Nathanson, Katherine L.
CA TECAC Consortium
TI Imputation and meta-analysis of five genome-wide association studies
   identify multiple new loci associated with testicular germ cell tumor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wang, Zhaoming; McGlynn, Katherine A.; Chung, Charles C.; Loud, Jennifer T.; Schwartz, Stephen] NCI, Bethesda, MD 20892 USA.
   [Kanetsky, Peter A.] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA.
   [Bishop, D. Timothy] Univ Leeds, Leeds LS2 9JT, W Yorkshire, England.
   [Dalgaard, Marlene D.; Rajpert-DeMeyts, Ewa] Copenhagen Univ Hosp, Copenhagen, Denmark.
   [Grotmol, Tom] Canc Registry Norway, Oslo, Norway.
   [Gupta, Ramneek; Nielsen, Kasper] Tech Univ Denmark, Lyngby, Denmark.
   [Haugen, Trine B.] Oslo & Akershus Univ, Coll Appl Sci, Oslo, Norway.
   [Litchfield, Kevin] Royal Canc Hosp, Inst Canc Res, London, England.
   [Mitra, Nandita; Nathanson, Katherine L.] Univ Penn, Philadelphia, PA 19104 USA.
   [Turnbull, Clare] Inst Canc Res, London, England.
   [Vardhanabhuti, Saran] Harvard Univ, Cambridge, MA 02138 USA.
   [Wiklund, Fredrik] Karolinska Inst, S-10401 Stockholm, Sweden.
   [Chanock, Stephen J.] Fred Hutchinson Canc Res Ctr, Seattle, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 843
DI 10.1158/1538-7445.AM2015-843
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501296
ER

PT J
AU Watson, IR
   Wu, CJ
   Zou, LH
   Gershenwald, JE
   Chin, L
AF Watson, Ian R.
   Wu, Chang-Jiun
   Zou, Lihua
   Gershenwald, Jeffrey E.
   Chin, Lynda
CA Melanoma Anal Working Grp
   Canc Genome Anal Res Network
TI Genomic classification of cutaneous melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Watson, Ian R.; Wu, Chang-Jiun; Gershenwald, Jeffrey E.; Chin, Lynda] MD Anderson, Houston, TX USA.
   [Zou, Lihua] Eli & Edythe L Broad Inst, Boston, MA USA.
   [Canc Genome Anal Res Network] NCI, NHGRI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2972
DI 10.1158/1538-7445.AM2015-2972
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506116
ER

PT J
AU Wen, B
   Zhang, ML
   Dilillo, D
   Ravetch, JV
   Waldmann, TA
AF Wen, Bernard
   Zhang, Meili
   Dilillo, David
   Ravetch, Jeffrey V.
   Waldmann, Thomas A.
TI Interleukin-15 enhances rituximab-dependent cytotoxicity ex vivo and in
   vivo against a mouse lymphoma expressing human CD20
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wen, Bernard; Zhang, Meili; Waldmann, Thomas A.] NCI, Bethesda, MD 20892 USA.
   [Dilillo, David; Ravetch, Jeffrey V.] Rockefeller Univ, New York, NY 10021 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1332
DI 10.1158/1538-7445.AM2015-1332
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502370
ER

PT J
AU Weng, DY
   Chen, JG
   Taslim, C
   Hsu, PC
   Marian, C
   David, SP
   Loffredo, CA
   Shields, PG
AF Weng, Daniel Y.
   Chen, Jinguo
   Taslim, Cenny
   Hsu, Ping-Ching
   Marian, Catalin
   David, Sean P.
   Loffredo, Christopher A.
   Shields, Peter G.
TI Persistent alterations of gene expression profiling of human peripheral
   blood mononuclear cells from smokers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Weng, Daniel Y.; Taslim, Cenny; Hsu, Ping-Ching; Marian, Catalin; Shields, Peter G.] Ohio State Univ, Columbus, OH 43210 USA.
   [Chen, Jinguo] NIH, Bethesda, MD 20892 USA.
   [David, Sean P.] Stanford Univ, Stanford, CA 94305 USA.
   [Loffredo, Christopher A.] Georgetown Univ, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 833
DI 10.1158/1538-7445.AM2015-833
PG 3
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501286
ER

PT J
AU Wentzensen, NA
   Poole, E
   Arslan, AA
   Patel, AV
   Setiawan, VW
   Visvanathan, K
   Weiderpass, E
   White, E
   Adami, HO
   Brinton, LA
   Bernstein, L
   Buring, J
   Butler, LM
   Chamosa, S
   Clendenen, TV
   Dossus, L
   Fortner, R
   Gapstur, SM
   Gaudet, MM
   Gram, IT
   Hartge, P
   Hoffman-Bolton, J
   Idahl, A
   Jones, M
   Kaaks, R
   Kirsh, V
   Koh, WP
   Lacey, JV
   Lee, IM
   Lundin, E
   Merritt, M
   Peters, U
   Poynter, J
   Rinaldi, S
   Robien, K
   Rohan, T
   Sandler, DP
   Schouten, LJ
   Sjoholm, L
   Sieri, S
   Swerdlow, A
   Tjonneland, A
   Trabert, B
   Wilkens, L
   Wolk, A
   Yang, HP
   Zeleniuch-Jacquotte, A
   Tworoger, SS
AF Wentzensen, Nicolas A.
   Poole, Elizabeth
   Arslan, Alan A.
   Patel, Alpa V.
   Setiawan, V. Wendy
   Visvanathan, Kala
   Weiderpass, Elisabete
   White, Emily
   Adami, Hans-Olov
   Brinton, Louise A.
   Bernstein, Leslie
   Buring, Julie
   Butler, Lesley M.
   Chamosa, Saioa
   Clendenen, Tess V.
   Dossus, Laure
   Fortner, Renee
   Gapstur, Susan M.
   Gaudet, Mia M.
   Gram, Inger Torhild
   Hartge, Patricia
   Hoffman-Bolton, Judith
   Idahl, Annika
   Jones, Michael
   Kaaks, Rudolf
   Kirsh, Vivki
   Koh, Woon-Puay
   Lacey, James V.
   Lee, I-Min
   Lundin, Eva
   Merritt, Melissa
   Peters, Ulrike
   Poynter, Jenny
   Rinaldi, Sabina
   Robien, Kim
   Rohan, Thomas
   Sandler, Dale P.
   Schouten, Leo J.
   Sjoholm, Louise
   Sieri, Sabina
   Swerdlow, Anthony
   Tjonneland, Anne
   Trabert, Britton
   Wilkens, Lynne
   Wolk, Alicja
   Yang, Hannah P.
   Zeleniuch-Jacquotte, Anne
   Tworoger, Shelley S.
TI Ovarian cancer risk factors by histologic subtypes: evidence for
   etiologic heterogeneity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Wentzensen, Nicolas A.; Brinton, Louise A.; Hartge, Patricia; Trabert, Britton; Yang, Hannah P.] NCI, Bethesda, MD 20892 USA.
   [Poole, Elizabeth] Harvard Univ, Sch Med, Boston, MA USA.
   [Poole, Elizabeth; Buring, Julie; Lee, I-Min; Tworoger, Shelley S.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Arslan, Alan A.; Clendenen, Tess V.; Zeleniuch-Jacquotte, Anne] NYU, Langone Med Ctr, New York, NY USA.
   [Patel, Alpa V.; Gapstur, Susan M.; Gaudet, Mia M.] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Setiawan, V. Wendy] Univ So Calif, Los Angeles, CA USA.
   [Visvanathan, Kala] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA.
   [Weiderpass, Elisabete; Sjoholm, Louise; Wolk, Alicja] Karolinska Inst, Stockholm, Sweden.
   [White, Emily; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Adami, Hans-Olov] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Bernstein, Leslie; Lacey, James V.] City Hope Natl Med Ctr, Duarte, CA USA.
   [Buring, Julie; Lee, I-Min; Tworoger, Shelley S.] Harvard Univ, Sch Publ Hlth, Harvard Med Sch, Boston, MA 02115 USA.
   [Butler, Lesley M.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Butler, Lesley M.] Univ Pittsburgh, Pittsburgh, PA USA.
   [Chamosa, Saioa] BioDonostia Res Inst, San Sebastian, Spain.
   [Dossus, Laure] INSERM, F-75654 Paris 13, France.
   [Fortner, Renee; Kaaks, Rudolf] German Canc Res Ctr, Heidelberg, Germany.
   [Gram, Inger Torhild] Univ Tromso, Tromso, Norway.
   [Hoffman-Bolton, Judith] Johns Hopkins Sch Publ Hlth, Hagerstown, MD USA.
   [Idahl, Annika; Lundin, Eva] Umea Univ, Umea, Sweden.
   [Jones, Michael; Swerdlow, Anthony] Inst Canc Res, London SW3 6JB, England.
   [Kirsh, Vivki] Canc Care Ontario, Toronto, ON, Canada.
   [Kirsh, Vivki] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
   [Koh, Woon-Puay] Duke NUS Grad Med Sch Singapore, Singapore, Singapore.
   [Koh, Woon-Puay] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore.
   [Merritt, Melissa] Univ London Imperial Coll Sci Technol & Med, London, England.
   [Poynter, Jenny] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
   [Rinaldi, Sabina] Int Agcy Res Canc, Lyon, France.
   [Robien, Kim] George Washington Univ, Washington, DC USA.
   [Rohan, Thomas] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Sandler, Dale P.] NIEHS, Res Triangle Pk, NC 27709 USA.
   [Schouten, Leo J.] Maastricht Univ, NL-6200 MD Maastricht, Netherlands.
   [Sieri, Sabina] Fdn IRCCS Ist Nazl Tumori, Milan, Italy.
   [Tjonneland, Anne] Ctr Canc Res, Copenhagen, Denmark.
   [Wilkens, Lynne] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
RI Sieri, Sabina/K-4667-2016; Weiderpass, Elisabete/M-4029-2016
OI Sieri, Sabina/0000-0001-5201-172X; Weiderpass,
   Elisabete/0000-0003-2237-0128
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 854
DI 10.1158/1538-7445.AM2015-854
PG 4
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501307
ER

PT J
AU Yang, HH
   Liu, HT
   Lubet, R
   Grubbs, CJ
   Nicastro, H
   Lee, MP
AF Yang, Howard H.
   Liu, Huaitian
   Lubet, Ronald
   Grubbs, Clinton J.
   Nicastro, Holly
   Lee, Maxwell P.
TI Correlation between modulation of RNA expression and the preventive and
   therapeutic efficacy of Tamoxifen in an ER plus model of breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Howard H.; Liu, Huaitian; Lubet, Ronald; Lee, Maxwell P.] NIH, Rockville, MD USA.
   [Grubbs, Clinton J.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Nicastro, Holly] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 896
DI 10.1158/1538-7445.AM2015-896
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501348
ER

PT J
AU Yang, SH
   He, PJ
   Wang, J
   Schetter, A
   Tang, W
   Funamizu, N
   Gaedcke, J
   Ghadimi, M
   Gaida, M
   Ried, T
   Hannah, N
   Alexander, HR
   Hussain, SP
AF Yang, Shouhui
   He, Peijun
   Wang, Jian
   Schetter, Aaron
   Tang, Wei
   Funamizu, Naotake
   Gaedcke, Jochen
   Ghadimi, Michael
   Gaida, Matthias
   Ried, Thomas
   Hannah, Nader
   Alexander, H. Richard
   Hussain, S. Perwez
TI Macrophage migration inhibitory factor (MIF) and miR-301b interactively
   enhance disease aggressiveness by targeting NR3C2 (nuclear receptor
   subfamily group c member 2) in human pancreatic cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Shouhui; He, Peijun; Wang, Jian; Schetter, Aaron; Tang, Wei; Gaida, Matthias; Ried, Thomas; Hussain, S. Perwez] NCI, Bethesda, MD 20892 USA.
   [Funamizu, Naotake] Jikei Univ, Sch Med, Tokyo, Japan.
   [Gaedcke, Jochen] Univ Med Ctr Gottingen, Gottingen, Germany.
   [Ghadimi, Michael] Univ Med Ctr Gottingen, Dept Gen Visceral & Pediat Surg, Gottingen, Germany.
   [Hannah, Nader; Alexander, H. Richard] Univ Maryland, Sch Med, College Pk, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 922
DI 10.1158/1538-7445.AM2015-922
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578501373
ER

PT J
AU Yang, XH
   Shi, JX
   Bennett, H
   Burke, L
   Dagnall, C
   Burdette, L
   Hicks, B
   Tucker, M
   Goldstein, A
AF Yang, Xiaohong (Rose)
   Shi, Jianxin
   Bennett, Hunter
   Burke, Laura
   Dagnall, Casey
   Burdette, Laurie
   Hicks, Belynda
   Tucker, Margaret
   Goldstein, Alisa
TI Germline copy number variations in melanoma families with/without
   CDKN2A/CDK4 mutations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Xiaohong (Rose); Shi, Jianxin; Bennett, Hunter; Burke, Laura; Dagnall, Casey; Burdette, Laurie; Hicks, Belynda; Tucker, Margaret; Goldstein, Alisa] NCI, NIH, DHHS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2755
DI 10.1158/1538-7445.AM2015-2755
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578505341
ER

PT J
AU Yang, XP
   Cheng, H
   Saleh, A
   Cornelius, S
   Guven-Maiorov, E
   Nussinov, R
   Van Weas, C
   Chen, Z
   Keskin, O
   Gursoy, A
AF Yang, Xinping
   Cheng, Hui
   Saleh, Anthony
   Cornelius, Shaleeka
   Guven-Maiorov, Emine
   Nussinov, Ruth
   Van Weas, Carter
   Chen, Zhong
   Keskin, Ozlem
   Gursoy, Attila
TI Altered inflammatory and death pathways in head and neck cell lines
   model genomic and expression signatures identified in The Cancer Genome
   Atlas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yang, Xinping; Cheng, Hui; Saleh, Anthony; Cornelius, Shaleeka; Van Weas, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
   [Guven-Maiorov, Emine; Keskin, Ozlem; Gursoy, Attila] Koc Univ, Ctr Computat Biol & Bioinformat, Istanbul, Turkey.
   [Nussinov, Ruth] NCI, Canc & Inflammat Program, Leidos Biomed Res Inc, Frederick, MD 21701 USA.
RI Gursoy, Attila/E-9565-2015
OI Gursoy, Attila/0000-0002-2297-2113
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1111
DI 10.1158/1538-7445.AM2015-1111
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502153
ER

PT J
AU Ye, XY
   Turbyville, TJ
   Bagni, R
   McCormick, F
   Whiteley, G
   Blonder, J
AF Ye, Xiaoying
   Turbyville, Thomas J.
   Bagni, Rachel
   McCormick, Franck
   Whiteley, Gordon
   Blonder, Josip
TI Comparative surface proteomics of NCI-H2122 cells reveals distinct cell
   surface phenotype of a metastatic NSCLC cell line expressing oncogenic
   KRASG12C
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Ye, Xiaoying; Turbyville, Thomas J.; Bagni, Rachel; McCormick, Franck; Whiteley, Gordon; Blonder, Josip] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1829
DI 10.1158/1538-7445.AM2015-1829
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578503314
ER

PT J
AU Yi, M
   Kessing, B
   Stephens, R
AF Yi, Ming
   Kessing, Bailey
   Stephens, Robert
TI Interpreting and navigating the TCGA in the context of the RAS pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Yi, Ming; Kessing, Bailey; Stephens, Robert] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 1092
DI 10.1158/1538-7445.AM2015-1092
PG 1
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578502134
ER

PT J
AU Zheng, S
   Cherniack, AD
   Dewal, N
   Moffitt, RA
   Danilova, L
   Murray, BA
   Lerario, AM
   Else, T
   Knijnenburg, TA
   Ciriello, G
   Kim, S
   Assie, G
   Morozova, O
   Akbani, R
   Shih, J
   Hoadley, KA
   Choueiri, TK
   Choueiril, TK
   Mete, O
   Robertson, GA
   Meyerson, M
   Demeure, MJ
   Beuschlein, F
   Gill, A
   Latronico, AC
   Fragosa, MC
   Cope, L
   Kebebew, E
   Habra, MA
   Whitsett, TG
   Bussey, KJ
   Rainey, WE
   Asa, S
   Bertherat, J
   Fassnacht, M
   Wheeler, DA
   Hammer, GD
   Giordano, TJ
   Verhaak, R
AF Zheng, Siyuan
   Cherniack, Andrew D.
   Dewal, Ninad
   Moffitt, Richard A.
   Danilova, Ludmila
   Murray, Bradley A.
   Lerario, Antonio M.
   Else, Tobias
   Knijnenburg, Theo A.
   Ciriello, Giovanni
   Kim, Seungchan
   Assie, Guillaume
   Morozova, Olena
   Akbani, Rehan
   Shih, Juliann
   Hoadley, Katherine A.
   Choueiri, Toni K.
   Waldmann, Jens
   Mete, Ozgur
   Robertson, Gordon A.
   Meyerson, Matthew
   Demeure, Michael J.
   Beuschlein, Felix
   Gill, Anthony
   Latronico, Ana C.
   Fragosa, Maria C.
   Cope, Leslie
   Kebebew, Electron
   Habra, Mouhammed A.
   Whitsett, Timothy G.
   Bussey, Kimberly J.
   Rainey, William E.
   Asa, Sylvia
   Bertherat, Jerome
   Fassnacht, Martin
   Wheeler, David A.
   Hammer, Gary D.
   Giordano, Thomas J.
   Verhaak, Roel
CA Canc Genome Atlas Res Network
TI Comprehensive Pan-Genomic characterization of adrenocortical carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Zheng, Siyuan; Akbani, Rehan; Habra, Mouhammed A.; Verhaak, Roel] UT MD Anderson Canc Ctr, Houston, TX USA.
   [Cherniack, Andrew D.; Murray, Bradley A.; Shih, Juliann] Broad Inst Harvard & MIT, Cambridge, MA USA.
   [Dewal, Ninad; Wheeler, David A.] Baylor Coll Med, Houston, TX 77030 USA.
   [Moffitt, Richard A.; Hoadley, Katherine A.] Univ N Carolina, Chapel Hill, NC USA.
   [Danilova, Ludmila; Cope, Leslie] Johns Hopkins Univ, Baltimore, MD USA.
   [Lerario, Antonio M.; Else, Tobias; Rainey, William E.; Hammer, Gary D.; Giordano, Thomas J.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Knijnenburg, Theo A.] Inst Syst Biol, Seattle, WA USA.
   [Ciriello, Giovanni] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Kim, Seungchan; Demeure, Michael J.; Whitsett, Timothy G.; Bussey, Kimberly J.] Translat Genom Res Inst, Phoenix, AZ USA.
   [Assie, Guillaume; Bertherat, Jerome] Inst Cochin Genet Mol, F-75014 Paris, France.
   [Morozova, Olena] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA.
   [Choueiri, Toni K.; Meyerson, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Waldmann, Jens] Univ Hosp Marburg, Marburg, Germany.
   [Mete, Ozgur; Asa, Sylvia] Univ Hlth Network, Toronto, ON, Canada.
   [Robertson, Gordon A.] Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada.
   [Beuschlein, Felix] Univ Munich, Munich, Germany.
   [Gill, Anthony] Univ Sydney, Sydney, NSW 2006, Australia.
   [Latronico, Ana C.; Fragosa, Maria C.] Univ Sao Paulo, Sao Paulo, Brazil.
   [Kebebew, Electron] NCI, Bethesda, MD 20892 USA.
   [Fassnacht, Martin] Univ Hosp Wuerzburg, Wurzburg, Germany.
NR 0
TC 1
Z9 1
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 2976
DI 10.1158/1538-7445.AM2015-2976
PG 2
WC Oncology
SC Oncology
GA DF8AH
UT WOS:000371578506120
ER

PT J
AU Lui, JC
   Garrison, P
   Baron, J
AF Lui, Julian C.
   Garrison, Presley
   Baron, Jeffrey
TI Regulation of body growth
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE body size; endocrine; genetic program; growth plate; proliferation
ID GENOME-WIDE ASSOCIATION; ESTROGEN-RECEPTOR-ALPHA; YES-ASSOCIATED
   PROTEIN; CAUSE WEAVER SYNDROME; ADULT HUMAN HEIGHT; FACTOR 21 FGF21; I
   IGF-I; CELL-PROLIFERATION; POSTNATAL-GROWTH; SHORT STATURE
AB Purpose of review
   Recent basic studies have yielded important new insights into the molecular mechanisms that regulate growth locally. Simultaneously, clinical studies have identified new molecular defects that cause growth failure and overgrowth, and genome-wide association studies have elucidated the genetic basis for normal human height variation.
   Recent findings
   The Hippo pathway has emerged as one of the major mechanisms controlling organ size. In addition, an extensive genetic program has been described that allows rapid body growth in the fetus and infant but then causes growth to slow with age in multiple tissues. In human genome-wide association studies, hundreds of loci associated with adult stature have been identified; many appear to involve genes that function locally in the growth plate. Clinical genetic studies have identified a new genetic abnormality, microduplication of Xq26.3, that is responsible for growth hormone excess, and a gene, DNMT3A, in which mutations cause an overgrowth syndrome through epigenetic mechanisms.
   Summary
   These recent advances in our understanding of somatic growth not only provide insight into childhood growth disorders but also have broader medical applications because disruption of these regulatory systems contributes to oncogenesis.
C1 [Lui, Julian C.; Garrison, Presley; Baron, Jeffrey] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, NIH, Bethesda, MD USA.
RP Baron, J (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Dev, NIH, CRC, Room 1-3330,10 Ctr Dr,MSC 1103, Bethesda, MD 20892 USA.
EM jeffrey.baron@nih.gov
RI Lui, Chun Kin Julian/E-2253-2012
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, NIH
FX This work was supported by the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, NIH.
NR 88
TC 2
Z9 2
U1 3
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8703
EI 1531-698X
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD AUG
PY 2015
VL 27
IS 4
BP 502
EP 510
DI 10.1097/MOP.0000000000000235
PG 9
WC Pediatrics
SC Pediatrics
GA DD2AL
UT WOS:000369724600016
PM 26087427
ER

PT J
AU Gordon, CM
   Kanaoka, T
   Nelson, LM
AF Gordon, Catherine M.
   Kanaoka, Tsuzuki
   Nelson, Lawrence M.
TI Update on primary ovarian insufficiency in adolescents
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE adolescence; amenorrhea; genetic origins; premature menopause; premature
   ovarian failure; primary ovarian insufficiency
ID HORMONE RECEPTOR GENE; RANDOMIZED CONTROLLED-TRIAL; FRAGILE-X
   PREMUTATION; BONE-MINERAL DENSITY; YOUNG-WOMEN; POSTMENOPAUSAL WOMEN;
   REPLACEMENT THERAPY; CHROMOSOMAL INSTABILITY; VENOUS THROMBOEMBOLISM;
   CLINICAL-FEATURES
AB Purpose of review
   We provide an overview of new insights into the genetic causes of primary ovarian insufficiency (POI) and address the challenges faced by clinicians who care for adolescents with this condition.
   Recent findings
   In most cases, the cause of POI remains a mystery after appropriate clinical testing has been completed. Large-scale genomic sequencing approaches are uncovering new mechanisms underlying the disorder. Gene variants that affect the normal processes of primordial germ-cell proliferation and migration, oocyte meiosis, and ovarian follicle formation/activation are plausible mechanisms. Whole exome sequencing has been used to associate many of these variants with human POI. POI is a serious chronic condition with no cure. It qualifies as a rare disease and as such presents special challenges to patients, parents, and clinicians. Although the diagnosis of POI is often delayed because of the assumption that irregular menses are common among adolescents, early detection is critical for the maintenance of bone and cardiovascular health. Treatment options have focused on hormonal therapy and fertility preservation. However, many studies prove the increasing need to incorporate mental health support and a family systems approach into the management plan.
   Summary
   Large-scale genomic sequencing has recently identified new mechanisms of POI. However, at present this testing is not clinically indicated as routine. Practice will change as genomic medicine is integrated into standard care. Adolescents with POI are best served by an integrated personal care approach centered on the patient and provided by a primary care clinician who has support from a multidisciplinary team.
C1 [Gordon, Catherine M.; Kanaoka, Tsuzuki] Brown Univ, Alpert Med Sch, Hasbro Childrens Hosp, Div Adolescent Med & Endocrinol,Dept Pediat, Potter 200-8,593 Eddy St, Providence, RI 02903 USA.
   [Kanaoka, Tsuzuki] Brown Univ, Dept Hlth & Human Biol, Providence, RI 02912 USA.
   [Nelson, Lawrence M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
RP Gordon, CM (reprint author), Brown Univ, Alpert Med Sch, Hasbro Childrens Hosp, Div Adolescent Med & Endocrinol,Dept Pediat, Potter 200-8,593 Eddy St, Providence, RI 02903 USA.
EM catherine_gordon@brown.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Bethesda, MD, USA
FX The authors thank the Intramural Research Program of the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development,
   National Institutes of Health, Bethesda, MD, USA, for support of the
   research effort on primary ovarian insufficiency and for making the
   preparation of this manuscript possible.
NR 75
TC 2
Z9 2
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8703
EI 1531-698X
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD AUG
PY 2015
VL 27
IS 4
BP 511
EP 519
DI 10.1097/MOP.0000000000000236
PG 9
WC Pediatrics
SC Pediatrics
GA DD2AL
UT WOS:000369724600017
PM 26087426
ER

PT J
AU Pollack, MM
   Holubkov, R
   Funai, T
   Berger, JT
   Clark, AE
   Meert, K
   Berg, RA
   Carcillo, J
   Wessel, DL
   Moler, F
   Dalton, H
   Newth, CJL
   Shanley, T
   Harrison, RE
   Doctor, A
   Jenkins, TL
   Tamburro, R
   Dean, JM
AF Pollack, Murray M.
   Holubkov, Richard
   Funai, Tomohiko
   Berger, John T.
   Clark, Amy E.
   Meert, Kathleen
   Berg, Robert A.
   Carcillo, Joseph
   Wessel, David L.
   Moler, Frank
   Dalton, Heidi
   Newth, Christopher J. L.
   Shanley, Thomas
   Harrison, Rick E.
   Doctor, Allan
   Jenkins, Tammara L.
   Tamburro, Robert
   Dean, J. Michael
CA Eunice Kennedy Shriver Natl Inst C
TI Simultaneous Prediction of New Morbidity, Mortality, and Survival
   Without New Morbidity From Pediatric Intensive Care: A New Paradigm for
   Outcomes Assessment
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE critical care; functional status; functional status score; intensive
   care; morbidity; outcome prediction; pediatric critical care; pediatric
   intensive care; pediatrics; severity of illness
ID CHRONIC HEALTH EVALUATION; MULTIPLE ORGAN DYSFUNCTION; NEONATAL ACUTE
   PHYSIOLOGY; HOSPITAL-WIDE MORTALITY; FUNCTIONAL STATUS SCALE;
   CRITICALLY-ILL PATIENTS; VERMONT OXFORD NETWORK; TRAUMATIC BRAIN-INJURY;
   CARDIAC-ARREST; PERFORMANCE CATEGORY
AB Objectives: Assessments of care including quality assessments adjusted for physiological status should include the development of new morbidities as well as mortalities. We hypothesized that morbidity, like mortality, is associated with physiological dysfunction and could be predicted simultaneously with mortality.
   Design: Prospective cohort study from December 4, 2011, to April 7, 2013.
   Setting: General and cardiac/cardiovascular PICUs at seven sites.
   Patients: Randomly selected PICU patients from their first PICU admission.
   Interventions: None.
   Measurements and Main Results: Among 10,078 admissions, the unadjusted morbidity rates (measured with the Functional Status Scale and defined as an increase of >= 3 from preillness to hospital discharge) were 4.6% (site range, 2.6-7.7%) and unadjusted mortality rates were 2.7% (site range, 1.3-5.0%). Morbidity and mortality were significantly (p < 0.001) associated with physiological instability (measured with the Pediatric Risk of Mortality III score) in dichotomous (survival and death) and trichotomous (survival without new morbidity, survival with new morbidity, and death) models without covariate adjustments. Morbidity risk increased with increasing Pediatric Risk of Mortality III scores and then decreased at the highest Pediatric Risk of Mortality III values as potential morbidities became mortalities. The trichotomous model with covariate adjustments included age, admission source, diagnostic factors, baseline Functional Status Scale, and the Pediatric Risk of Mortality III score. The three-level goodness-of-fit test indicated satisfactory performance for the derivation and validation sets (p > 0.20). Predictive ability assessed with the volume under the surface was 0.50 +/- 0.019 (derivation) and 0.50 +/- 0.034 (validation) (vs chance performance = 0.17). Site-level standardized morbidity ratios were more variable than standardized mortality ratios.
   Conclusions: New morbidities were associated with physiological status and can be modeled simultaneously with mortality. Trichotomous outcome models including both morbidity and mortality based on physiological status are suitable for research studies and quality and other outcome assessments. This approach may be applicable to other assessments presently based only on mortality.
C1 [Pollack, Murray M.; Berger, John T.; Wessel, David L.] Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USA.
   [Pollack, Murray M.] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA.
   [Pollack, Murray M.; Dalton, Heidi] Phoenix Childrens Hosp, Dept Child Hlth, Phoenix, AZ USA.
   [Pollack, Murray M.] Univ Arizona, Sch Med, Phoenix, AZ USA.
   [Holubkov, Richard; Funai, Tomohiko; Clark, Amy E.; Dean, J. Michael] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA.
   [Meert, Kathleen] Childrens Hosp Michigan, Dept Pediat, Washington, DC USA.
   [Berg, Robert A.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
   [Carcillo, Joseph] Childrens Hosp Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15213 USA.
   [Moler, Frank; Shanley, Thomas] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Dalton, Heidi] Univ Arizona, Coll Med, Phoenix, AZ USA.
   [Newth, Christopher J. L.] Childrens Hosp Los Angeles, Dept Anesthesiol & Crit Care Med, Los Angeles, CA 90027 USA.
   [Harrison, Rick E.] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA.
   [Doctor, Allan] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
   [Doctor, Allan] Washington Univ, Sch Med, Dept Biochem, St Louis, MO 63110 USA.
   [Jenkins, Tammara L.; Tamburro, Robert] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Trauma & Crit Illness Branch, NIH, Bethesda, MD USA.
RP Pollack, MM (reprint author), Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USA.
EM mpollack@childrensnational.org
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Department of Health and
   Human Services [U10HD050096, U10HD049981, U10HD049983, U10HD050012,
   U10HD063108, U10HD063106, U10HD063114, U01HD049934]; National Institute
   of Child Health and Human Development (NICHD); National Institutes of
   Health (NIH); Association for Pediatric Pulmonary Hypertension; NICHD;
   NIH/NICHD (Collaborative Pediatric Critical Care Research Network);
   NICHD (Collaborative Pediatric Critical Care Research Network [CPCCRN]
   grant); NIH (Clinical and Translational Science Award grant); NICHD
   (CPCCRN grant); NIH (CPCCRN); NIH (Therapeutic Hypothermia for Pediatric
   Cardiac Arrest); American Hospital Association; Children's Discovery
   Institute; U.S. Food and Drug Administration Office of Orphan Product
   Development Grant; Health Services and Resources Administration
FX Supported, in part, by the following cooperative agreements from the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Department of Health and
   Human Services: U10HD050096, U10HD049981, U10HD049983, U10HD050012,
   U10HD063108, U10HD063106, U10HD063114, and U01HD049934.; Dr. Pollack
   received grant support from the National Institute of Child Health and
   Human Development (NICHD), has planned patents through Children's
   National Medical Center (his not-for-profit employer), and received
   support for article research from the National Institutes of Health
   (NIH). Dr. Holubkov served as a board member for Pfizer, the National
   Burn Association, and Fibrocell (Data Safety Board Membership);
   consulted for St. Jude Medical, Physicians Committee for Responsible
   Medicine, and Covidien (Biostatistical Consulting); received support for
   article research from the NIH. Dr. Holubkov and his institution received
   grant support (Salary support [biostatistician]) and support for travel
   (Steering Committee Meeting Travel) from the NIH. Dr. Funai received
   support for article research from the NIH. Dr. Funai and his institution
   received grant support from the NIH (salaries support Biostatistician).
   Dr. Berger received support for article research from the NIH. His
   institution received grant support from the NIH and the Association for
   Pediatric Pulmonary Hypertension. Dr. Clark received support for article
   research from the NIH. Her institution received grant support from the
   NIH. Dr. Meert received support for article research from the NIH. Her
   institution received grant support from the NIH. Dr. Berg received grant
   support from the NICHD and received support for article research from
   the NIH. Dr. Carcillo received support for article research from the
   NIH. His institution received grant support and support for travel. Dr.
   Wessel received support for article research from the NIH. His
   institution received grant support from the NIH (ongoing). Dr. Moler
   received support for article research from the NIH. His institution
   received grant support and support for travel from the NICHD. Dr. Dalton
   lectured for rEVO Biologics, received royalties from the Society of
   Critical Care Medicine (SCCM) for Pediatric Multidisciplinary Board
   Review Book, and received support for article research from the NIH. Her
   institution received grant support from the NIH. Dr. Newth received
   support for article research from the NIH. His institution received
   grant support from the NIH/NICHD (Collaborative Pediatric Critical Care
   Research Network). Dr. Shanley received support for article research
   from the NIH and served as a board member for International Pediatric
   Research Foundation (Society for Pediatric Research Representative on
   Executive Committee). His institution received grant support from the
   NICHD (Collaborative Pediatric Critical Care Research Network [CPCCRN]
   grant) and the NIH (Clinical and Translational Science Award grant) and
   received support for travel from the NICHD (CPCCRN grant). Dr. Harrison
   lectured for the SCCM (board review lectures for my professional
   society) and received support for article research from the NIH. His
   institution received grant support from the NIH (CPCCRN funding and
   Therapeutic Hypothermia for Pediatric Cardiac Arrest trial funding via
   NIH). Dr. Doctor consulted for the NICHD/CPCCRN (honorarium to serve as
   Steering Committee chairperson), Terumo, BCT, iNO Therapeutics,
   Novartis, and Galleon Pharmaceuticals; received support for travel from
   the NICHD/CPCCRN; and lectured for Terumo, BCT. His institution received
   grant support from the NIH, the American Hospital Association, and the
   Children's Discovery Institute. Dr. Jenkins received support for article
   research from the NIH and disclosed government work. Dr. Tamburro
   received grant support from the U.S.; Food and Drug Administration
   Office of Orphan Product Development Grant to study calfactant in
   pediatric stem cell transplant patients (No longer co-principal
   investigator on the trial secondary to accepting a new position),
   received royalties from Springer Publisher (received royalties for
   serving as an associate editor on a pediatric critical care textbook and
   study guide), received support for article research from the NIH, and
   disclosed government work. Dr. Dean received support for article
   research from the NIH. His institution received grant support from the
   NIH and Health Services and Resources Administration.
NR 58
TC 21
Z9 21
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD AUG
PY 2015
VL 43
IS 8
BP 1699
EP 1709
DI 10.1097/CCM.0000000000001081
PG 11
WC Critical Care Medicine
SC General & Internal Medicine
GA DC5JA
UT WOS:000369256100036
PM 25985385
ER

PT J
AU Chen, I
   Connor, MB
   Clarke, W
   Marzinke, MA
   Cummings, V
   Breaud, A
   Fogel, JM
   Laeyendecker, O
   Fields, SD
   Donnell, D
   Griffith, S
   Scott, HM
   Shoptaw, S
   del Rio, C
   Magnus, M
   Mannheimer, S
   Wheeler, DP
   Mayer, KH
   Koblin, BA
   Eshleman, SH
AF Chen, Iris
   Connor, Matthew B.
   Clarke, William
   Marzinke, Mark A.
   Cummings, Vanessa
   Breaud, Autumn
   Fogel, Jessica M.
   Laeyendecker, Oliver
   Fields, Sheldon D.
   Donnell, Deborah
   Griffith, Sam
   Scott, Hyman M.
   Shoptaw, Steven
   del Rio, Carlos
   Magnus, Manya
   Mannheimer, Sharon
   Wheeler, Darrell P.
   Mayer, Kenneth H.
   Koblin, Beryl A.
   Eshleman, Susan H.
TI Antiretroviral Drug Use and HIV Drug Resistance Among HIV-Infected Black
   Men Who Have Sex With Men: HIV Prevention Trials Network 061
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV; drug resistance; antiretroviral drug; black; men who have sex with
   men
ID POPULATIONS; TRANSCRIPTASE; MANAGEMENT; MUTATIONS; TROPISM; RISK
AB Background: HIV Prevention Trials Network (HPTN) 061 enrolled black men who have sex with men in the United States. Some men with low/undetectable HIV RNA had unusual patterns of antiretroviral (ARV) drug use or had drugs detected in the absence of viral suppression. This report includes a comprehensive analysis of ARV drug use and drug resistance among men in HPTN 061 who were not virally suppressed.
   Methods: The analysis included 169 men who had viral loads >400 copies per milliliter at enrollment, including 3 with acute infection and 13 with recent infection. By self-report, 88 were previously diagnosed, including 31 in care; 137 men reported no ARV drug use. Samples from these 169 men and 23 seroconverters were analyzed with HIV genotyping and ARV drug assays.
   Results: Forty-eight (28%) of the 169 men had >= 1 drug resistance mutation (DRM); 19 (11%) had multiclass resistance. Sixty men (36%) had >= ARV drug detected, 42 (70%) of whom reported no ARV drug use. Nine (23%) of 39 newly infected men had >= 1 DRM; 10 had >= 1 ARV drug detected. Unusual patterns of ARV drugs were detected more frequently in newly diagnosed men than previously diagnosed men. The rate of transmitted drug resistance was 23% based on HIV genotyping and self-reported ARV drug use but was 12% after adjusting for ARV drug detection.
   Conclusions: Many men in HPTN 061 had drug-resistant HIV, and many were at risk of acquiring additional DRMs. ARV drug testing revealed unusual patterns of ARV drug use and provided a more accurate estimate of transmitted drug resistance.
C1 [Chen, Iris; Clarke, William; Marzinke, Mark A.; Cummings, Vanessa; Breaud, Autumn; Fogel, Jessica M.; Eshleman, Susan H.] Johns Hopkins Univ, Sch Med, Dept Pathol, Ross Bldg,Room 646,720 Rutland Ave, Baltimore, MD 21205 USA.
   [Connor, Matthew B.; Donnell, Deborah] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Laeyendecker, Oliver] NIAID, Immunoregulat Lab, NIH, Baltimore, MD USA.
   [Laeyendecker, Oliver] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Fields, Sheldon D.] Florida Int Univ, Coll Nursing & Hlth Sci, Miami, FL 33199 USA.
   [Donnell, Deborah] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
   [Griffith, Sam] FHI 360, Sci Facilitat Dept, Durham, NC USA.
   [Scott, Hyman M.] San Francisco Dept Publ Hlth, Bridge HIV, San Francisco, CA USA.
   [Shoptaw, Steven] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA.
   [del Rio, Carlos] Emory Univ, Rollins Sch Publ Hlth, Dept Global Hlth, Atlanta, GA 30322 USA.
   [Magnus, Manya] George Washington Univ, Dept Epidemiol & Biostat, Washington, DC USA.
   [Mannheimer, Sharon] Columbia Univ, Mailman Sch Publ Hlth, Harlem Hosp, Dept Med, New York, NY USA.
   [Wheeler, Darrell P.] Loyola Univ, Grad Sch Social Work, Chicago, IL 60611 USA.
   [Mayer, Kenneth H.] Fenway Inst, Div Fenway Hlth, Boston, MA USA.
   [Mayer, Kenneth H.] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA.
   [Mayer, Kenneth H.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA.
   [Koblin, Beryl A.] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA.
RP Eshleman, SH (reprint author), Johns Hopkins Univ, Sch Med, Dept Pathol, Ross Bldg,Room 646,720 Rutland Ave, Baltimore, MD 21205 USA.
EM seshlem@jhmi.edu
RI del Rio, Carlos/B-3763-2012; 
OI del Rio, Carlos/0000-0002-0153-3517; Donnell,
   Deborah/0000-0002-0587-7480
FU National Institute of Allergy and Infectious Diseases (NIAID); National
   Institutes of Child Health and Human Development (NICH/HD); National
   Institute of Drug Abuse (NIDA); National Institute of Mental Health
   (NIMH), Office of AIDS Research, National Institutes of Health (NIH),
   Department of Health and Human Services [UM1-AI068613, R01-AI095068,
   UM1-AI068617]; Division of Intramural Research, NIAID; Abbott
   Laboratories; Thermo Fisher Scientific
FX The HIV Prevention Trials Network (HPTN) is funded by the National
   Institute of Allergy and Infectious Diseases (NIAID), National
   Institutes of Child Health and Human Development (NICH/HD), National
   Institute of Drug Abuse (NIDA), and the National Institute of Mental
   Health (NIMH), Office of AIDS Research, National Institutes of Health
   (NIH), Department of Health and Human Services (UM1-AI068613 and
   R01-AI095068-S.H.E.; UM1-AI068617-D.D.). Additional support was provided
   by the Division of Intramural Research, NIAID.; S.H.E. has collaborated
   on research studies with investigators from Abbott Laboratories
   (distributor of the ViroSeq HIV-1 Genotyping System). Abbott
   Laboratories has provided reagents and performed testing for some
   collaborative studies. S.H.E. received an honorarium in 2009 for a
   presentation at a symposium sponsored by Abbott Laboratories. W.C.
   receives research support from Thermo Fisher Scientific, including
   monetary support, instrument placement, and reagents. W.C. also acts as
   a consultant for Thermo Fisher Scientific. The remaining authors have no
   conflicts of interest to disclose.
NR 36
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 1
PY 2015
VL 69
IS 4
BP 446
EP 452
DI 10.1097/QAI.0000000000000633
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DC5HK
UT WOS:000369251900013
PM 25861015
ER

PT J
AU Coutinho-Abreu, IV
   Guimaraes-Costa, AB
   Valenzuela, JG
AF Coutinho-Abreu, Iliano V.
   Guimaraes-Costa, Anderson B.
   Valenzuela, Jesus G.
TI Impact of insect salivary proteins in blood feeding, host immunity,
   disease, and in the development of biomarkers for vector exposure
SO CURRENT OPINION IN INSECT SCIENCE
LA English
DT Article
ID AEDES-AEGYPTI SALIVA; FLY LUTZOMYIA-LONGIPALPIS; DENGUE VIRUS-INFECTION;
   ANTIBODY-RESPONSE; PHLEBOTOMUS-PAPATASI; ANOPHELES-GAMBIAE; GLAND GENES;
   PLATELET-AGGREGATION; HUMAN KERATINOCYTES; BINDING PROTEIN
AB Functional genomic approaches based on expression of recombinant proteins linked to biochemical and disease model approaches resulted in the discovery of novel biological activities and the role some of these proteins play in disease transmission. Importantly, the expression of salivary proteins was recently shown to be affected by environmental factors and by the presence of the pathogen in the salivary gland. A practical application resulting from insect saliva research is the use of insect antigenic salivary protein as biomarkers of vector exposure in humans and animal reservoirs, an approach that is yielding interesting results in the field.
C1 [Coutinho-Abreu, Iliano V.; Guimaraes-Costa, Anderson B.; Valenzuela, Jesus G.] NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20878 USA.
RP Valenzuela, JG (reprint author), NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20878 USA.
EM jvalenzuela@niaid.nih.gov
FU Intramural Research Program of NIH, National Institute of Allergy and
   Infectious Diseases; CNPq-Brasil
FX We want to thank Dr. Jose M.C. Ribeiro for suggestions and critical
   reading of this manuscript. This work was supported by the Intramural
   Research Program of NIH, National Institute of Allergy and Infectious
   Diseases (IVCA, ABGC, JGV). ABGC fellowship is sponsored by CNPq-Brasil.
   This funding source had no involvement in the preparation of the
   manuscript and decision to publish this review.
NR 49
TC 3
Z9 3
U1 2
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2214-5745
EI 2214-5753
J9 CURR OPIN INSECT SCI
JI Curr. Opin. Insect Sci.
PD AUG
PY 2015
VL 10
BP 98
EP 103
DI 10.1016/j.cois.2015.04.014
PG 6
WC Biology; Ecology; Entomology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
   Ecology; Entomology
GA DC1ZR
UT WOS:000369017500015
PM 26339571
ER

PT J
AU Eckhoff, PA
   Bever, CA
   Gerardin, J
   Wenger, EA
   Smith, DL
AF Eckhoff, Philip A.
   Bever, Caitlin A.
   Gerardin, Jaline
   Wenger, Edward A.
   Smith, David L.
TI From puddles to planet: modeling approaches to vector-borne diseases at
   varying resolution and scale
SO CURRENT OPINION IN INSECT SCIENCE
LA English
DT Article
ID MALARIA TRANSMISSION; MATHEMATICAL-MODELS; DENGUE; POPULATION;
   INFECTION; MOSQUITOS; DYNAMICS; VACCINES; ECOLOGY; SIMULATION
AB Since the original Ross-Macdonald formulations of vector-borne disease transmission, there has been a broad proliferation of mathematical models of vector-borne disease, but many of these models retain most to all of the simplifying assumptions of the original formulations. Recently, there has been a new expansion of mathematical frameworks that contain explicit representations of the vector life cycle including aquatic stages, multiple vector species, host heterogeneity in biting rate, realistic vector feeding behavior, and spatial heterogeneity. In particular, there are now multiple frameworks for spatially explicit dynamics with movements of vector, host, or both. These frameworks are flexible and powerful, but require additional data to take advantage of these features. For a given question posed, utilizing a range of models with varying complexity and assumptions can provide a deeper understanding of the answers derived from models.
C1 [Eckhoff, Philip A.; Bever, Caitlin A.; Gerardin, Jaline; Wenger, Edward A.] Inst Dis Modeling, 1555 132nd Ave NE, Bellevue, WA 98005 USA.
   [Smith, David L.] Univ Oxford, Dept Zool, Spatial Ecol & Epidemiol Grp, Oxford OX1 3PS, England.
   [Smith, David L.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Eckhoff, PA (reprint author), Inst Dis Modeling, 1555 132nd Ave NE, Bellevue, WA 98005 USA.
EM peckhoff@Intven.com
RI Smith, David/L-8850-2013
OI Smith, David/0000-0003-4367-3849
FU Global Good Fund of Bellevue, WA; Bill & Melinda Gates Foundation
   [OPP1110495]; RAPIDD program of the Science & Technology Directorate,
   Department of Homeland Security; Fogarty International Center, National
   Institutes of Health
FX PAE, CAB, JG, and EAW are funded by the Global Good Fund of Bellevue, WA
   and would like to acknowledge many helpful discussions with colleagues
   at the Institute for Disease Modeling and other collaborators. DLS
   acknowledges funding from the Bill & Melinda Gates Foundation
   [#OPP1110495] and support from the RAPIDD program of the Science &
   Technology Directorate, Department of Homeland Security, and the Fogarty
   International Center, National Institutes of Health
   (http://www.fic.nih.gov).
NR 50
TC 1
Z9 1
U1 2
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2214-5745
EI 2214-5753
J9 CURR OPIN INSECT SCI
JI Curr. Opin. Insect Sci.
PD AUG
PY 2015
VL 10
BP 118
EP 123
DI 10.1016/j.cois.2015.05.002
PG 6
WC Biology; Ecology; Entomology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
   Ecology; Entomology
GA DC1ZR
UT WOS:000369017500018
ER

PT J
AU Baker, EH
   Levin, SW
   Zhang, ZJ
   Mukherjee, AB
AF Baker, Eva H.
   Levin, Sondra W.
   Zhang, Zhongjian
   Mukherjee, Anil B.
TI Evaluation of disease progression in INCL by MR spectroscopy
SO ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
LA English
DT Article
ID NEURONAL CEROID-LIPOFUSCINOSIS; MAGNETIC-RESONANCE-SPECTROSCOPY;
   LOCALIZED PROTON MRS; NIEMANN-PICK-DISEASE; N-ACETYLCYSTEINE; HUMAN
   BRAIN; METABOLITE; NCL; DISORDERS; CHILDHOOD
AB Objective: Infantile neuronal ceroid lipofuscinosis (INCL) is a devastating neurodegenerative storage disease caused by palmitoyl-protein thioesterase-1 deficiency, which impairs degradation of palmitoylated proteins (constituents of ceroid) by lysosomal hydrolases. Consequent lysosomal ceroid accumulation leads to neuronal injury. As part of a pilot study to evaluate treatment benefits of cysteamine bitartrate and N-acetylcysteine, we quantitatively measured brain metabolite levels using magnetic resonance spectroscopy (MRS). Methods: A subset of two patients from a larger treatment and follow-up study underwent serial quantitative single-voxel MRS examinations of five anatomical sites. Three echo times were acquired in order to estimate metabolite T2. Measured metabolite levels included correction for partial volume of cerebrospinal fluid. Comparison of INCL patients was made to a reference group composed of asymptomatic and minimally symptomatic Niemann-Pick disease type C patients. Results: In INCL patients, N-acetylaspartate (NAA) was abnormally low at all locations upon initial measurement, and further declined throughout the follow-up period. In the cerebrum (affected early in the disease course), choline and myo-inositol were initially elevated and fell during the follow-up period, whereas in the cerebellum and brainstem (affected later), choline and myo-inositol were initially normal and rose subsequently. Interpretation: Choline and myo-inositol levels in our patients are consistent with patterns of neuroinflammation observed in two INCL mouse models. Low, persistently declining NAA was expected based on the progressive, irreversible nature of the disease. Progression of metabolite levels in INCL has not been previously quantified; therefore the results of this study serve as a reference for quantitative evaluation of future therapeutic interventions.
C1 [Baker, Eva H.] NIH, Dept Radiol & Imaging Sci, Ctr Clin, Bethesda, MD 20892 USA.
   [Levin, Sondra W.; Zhang, Zhongjian; Mukherjee, Anil B.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, NIH, Bethesda, MD 20892 USA.
   [Levin, Sondra W.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD 20889 USA.
RP Baker, EH (reprint author), Bldg 10,Room 1C351,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bakere@mail.nih.gov
NR 43
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2328-9503
J9 ANN CLIN TRANSL NEUR
JI Ann. Clin. Transl. Neurol.
PD AUG
PY 2015
VL 2
IS 8
BP 797
EP 809
DI 10.1002/acn3.222
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CZ6UW
UT WOS:000367237500002
PM 26339674
ER

PT J
AU Huang, X
   Qiu, J
   Zhang, YQ
   Qiu, WT
   He, XC
   Wang, YX
   Sun, QM
   Zhao, N
   Cui, HM
   Liu, SF
   Tang, ZF
   Chen, Y
   Yue, L
   Da, ZQ
   Lv, L
   Lin, XJ
   Zhang, C
   Zhang, HH
   Xu, RF
   Zhu, DL
   Xu, XY
   Lin, R
   Yao, TT
   Su, J
   Dang, Y
   Han, XD
   Zhang, HR
   Bai, HY
   Wang, WD
   Wang, YY
   Liu, XH
   Ma, B
   Huang, H
   Liang, JX
   Jiang, M
   Ma, SG
   Bell, ML
   Kim, C
   Liu, Q
   Zhang, YW
AF Huang, Xin
   Qiu, Jie
   Zhang, Yaqun
   Qiu, Weitao
   He, Xiaochun
   Wang, Yixuan
   Sun, Qingmei
   Zhao, Nan
   Cui, Hongmei
   Liu, Sufen
   Tang, Zhongfeng
   Chen, Ya
   Yue, Li
   Da, Zhenqiang
   Lv, Ling
   Lin, Xiaojuan
   Zhang, Chong
   Zhang, Honghong
   Xu, Ruifeng
   Zhu, Daling
   Xu, Xiaoying
   Lin, Ru
   Yao, Tingting
   Su, Jie
   Dang, Yun
   Han, Xudong
   Zhang, Hanru
   Bai, Haiya
   Wang, Wendi
   Wang, Yueyuan
   Liu, Xiaohui
   Ma, Bin
   Huang, Huang
   Liang, Jiaxin
   Jiang, Min
   Ma, Shuangge
   Bell, Michelle L.
   Kim, Christopher
   Liu, Qing
   Zhang, Yawei
TI Ambient air pollutant PM10 and risk of pregnancy-induced hypertension in
   urban China
SO ENVIRONMENTAL RESEARCH LETTERS
LA English
DT Article
DE PM10; pregnancy-induced hypertension; birth cohort; epidemiology; China
ID PRETERM BIRTH; PREECLAMPSIA; MORTALITY; EXPOSURE; DISEASE
AB Background: The relationship between air borne particulatematter <= 10 mu m(PM10) exposure and pregnancy-induced hypertension (PIH) is inconclusive. Few studies have been conducted, and fewer were conducted in areas with high levels of PM10. Methods: To examine the association between PM10 and PIH by different exposure time windows during pregnancy, we analyzed data from a birth cohort study conducted in Lanzhou, China including 8 745 pregnant women with available information on air pollution during pregnancy. A total of 333 PIH cases (127 gestational hypertension (GH) and 206 preeclampsia (PE)) were identified. PM10 daily average concentrations of each subject were calculated according to the distance between home/work addresses and monitor stations using an inverse-distance weighting approach. Results: Average PM10 concentration over the duration of entire pregnancy was significantly associated with PIH(OR = 1.12, 95% CI: 1.02, 1.23 per 10 mu gm(-3) increase), PE (OR = 1.16, 95% CI: 1.03, 1.30 per 10 mu gm(-3) increase), late onset PE (OR = 1.17, 95% CI: 1.03, 1.32 per10 mu gm(-3) increase), and severe PE (OR = 1.25, 95% CI: 1.06, 1.48 per 10 mu gm(-3) increase). Average PM10 during the first 12 gestational weeks was associated with the risk of GH(OR = 1.10, 95% CI: 1.00, 1.21 per 10 mu gm(-3) increase), and PM10 exposure before 20 gestational weeks was associated with the risk of severe PE (OR = 1.14, 95% CI: 1.01, 1.30 per 10 mu gm(-3) increase). Conclusions: We found that high level exposure to ambient PM10 during pregnancy was associated with an increased risk of PIH, GH and PE and that the strength of the association varied by timing of exposure during pregnancy.
C1 [Huang, Xin] Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.
   [Huang, Xin; Zhao, Nan; Huang, Huang; Liang, Jiaxin; Ma, Shuangge; Zhang, Yawei] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
   [Qiu, Jie; Qiu, Weitao; He, Xiaochun; Wang, Yixuan; Sun, Qingmei; Cui, Hongmei; Liu, Sufen; Tang, Zhongfeng; Chen, Ya; Yue, Li; Da, Zhenqiang; Lv, Ling; Lin, Xiaojuan; Zhang, Chong; Zhang, Honghong; Xu, Ruifeng; Zhu, Daling; Xu, Xiaoying; Lin, Ru; Yao, Tingting; Su, Jie; Dang, Yun; Han, Xudong; Zhang, Hanru; Bai, Haiya; Wang, Wendi; Wang, Yueyuan; Liu, Xiaohui; Ma, Bin; Liu, Qing] Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China.
   [Zhang, Yaqun] Gansu Acad Environm Sci, Lanzhou, Gansu, Peoples R China.
   [Jiang, Min] Sichuan Univ, Sch Publ Hlth, Chengdu 610064, Sichuan, Peoples R China.
   [Bell, Michelle L.] Yale Univ, Sch Forestry & Environm Studies, New Haven, CT 06511 USA.
   [Kim, Christopher] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
RP Huang, X (reprint author), Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.
EM 2305470816@qq.com; yawei.zhang@yale.edu
FU Gansu Provincial Maternity and Child Care Hospital, Gansu Provincial
   Science and Technology Department Grant [1204WCGA021]; National
   Institutes of Health grant [K02HD70324]; China Medical Board
FX The study was supported by internal funding from the Gansu Provincial
   Maternity and Child Care Hospital, Gansu Provincial Science and
   Technology Department Grant (1204WCGA021), and the National Institutes
   of Health grant (K02HD70324). The first author Xin Huang was a visiting
   scholar at Yale School of Public Health and was funded by the China
   Medical Board.
NR 24
TC 0
Z9 0
U1 7
U2 11
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-9326
J9 ENVIRON RES LETT
JI Environ. Res. Lett.
PD AUG
PY 2015
VL 10
IS 8
AR 084025
DI 10.1088/1748-9326/10/8/084025
PG 8
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA CZ3JD
UT WOS:000366999400026
ER

PT J
AU Shah, MR
AF Shah, Monica R.
TI The Broad Spectrum of HIV-Related Cardiovascular Disease
SO JACC-HEART FAILURE
LA English
DT Editorial Material
DE clinical research; heart failure; HIV; HIV-related cardiovascular
   disease; pulmonary hypertension
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-HEART-DISEASE; SUDDEN CARDIAC DEATH; INFECTION; RISK; FAILURE;
   DYSFUNCTION; IMPACT
C1 [Shah, Monica R.] NHLBI, Div Cardiovasc Sci, Bethesda, MD 20892 USA.
   [Shah, Monica R.] NHLBI, AIDS Program, Bethesda, MD 20892 USA.
RP Shah, MR (reprint author), NHLBI, Div Cardiovasc Sci, 6701 Rockledge Dr,Room 8174, Bethesda, MD 20892 USA.
EM shahmr@nhlbi.nih.gov
NR 19
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1779
EI 2213-1787
J9 JACC-HEART FAIL
JI JACC-Heart Fail.
PD AUG
PY 2015
VL 3
IS 8
BP 600
EP 602
DI 10.1016/j.jchf.2015.04.007
PG 3
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA CX4FM
UT WOS:000365654400003
PM 26164680
ER

PT J
AU Spielberg, JM
   Jarcho, JM
   Dahl, RE
   Pine, DS
   Ernst, M
   Nelson, EE
AF Spielberg, Jeffrey M.
   Jarcho, Johanna M.
   Dahl, Ronald E.
   Pine, Daniel S.
   Ernst, Monique
   Nelson, Eric E.
TI Anticipation of peer evaluation in anxious adolescents: divergence in
   neural activation and maturation
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE anxiety; adolescence; anticipation; amygdala; nucleus accumbens
ID ANTERIOR CINGULATE CORTEX; HUMAN AMYGDALA; NUCLEUS-ACCUMBENS; ANXIETY;
   BRAIN; EMOTION; CONNECTIVITY; DEPRESSION; DISORDERS; CHILDHOOD
AB Adolescence is the time of peak onset for many anxiety disorders, particularly Social Anxiety Disorder. Research using simulated social interactions consistently finds differential activation in several brain regions in anxious (vs non-anxious) youth, including amygdala, striatum and medial prefrontal cortex. However, few studies examined the anticipation of peer interactions, a key component in the etiology and maintenance of anxiety disorders. Youth completed the Chatroom Task while undergoing functional magnetic resonance imaging. Patterns of neural activation were assessed in anxious and non-anxious youth as they were cued to anticipate social feedback from peers. Anxious participants evidenced greater amygdala activation and rostral anterior cingulate (rACC)<-> amygdala coupling than non-anxious participants during anticipation of feedback from peers they had previously rejected; anxious participants also evidenced less nucleus accumbens activation during anticipation of feedback from selected peers. Finally, anxiety interacted with age in rACC: in anxious participants, age was positively associated with activation to anticipated feedback from rejected peers and negatively for selected peers, whereas the opposite pattern emerged for non-anxious youth. Overall, anxious youth showed greater reactivity in anticipation of feedback from rejected peers and thus may ascribe greater salience to these potential interactions and increase the likelihood of avoidance behavior.
C1 [Spielberg, Jeffrey M.] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA.
   [Spielberg, Jeffrey M.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Jarcho, Johanna M.; Pine, Daniel S.; Ernst, Monique; Nelson, Eric E.] NIMH, Bethesda, MD 20814 USA.
   [Dahl, Ronald E.] Univ Calif Berkeley, Inst Human Dev, Berkeley, CA 94720 USA.
RP Spielberg, JM (reprint author), VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, 150 South Huntington Ave 182 JP, Boston, MA 02130 USA.
EM spielbergjm@gmail.com
OI Jarcho, Johanna/0000-0001-9075-6968; Nelson, Eric/0000-0002-3376-2453
FU National Institute of Mental Health
FX This study was supported by the intramural research program of the
   National Institute of Mental Health.
NR 51
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U1 6
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2015
VL 10
IS 8
BP 1084
EP 1091
DI 10.1093/scan/nsu165
PG 8
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA CX2PW
UT WOS:000365540100009
PM 25552568
ER

PT J
AU Kozlov, MM
   Chernomordik, LV
AF Kozlov, Michael M.
   Chernomordik, Leonid V.
TI Membrane tension and membrane fusion
SO CURRENT OPINION IN STRUCTURAL BIOLOGY
LA English
DT Article
ID CLATHRIN-MEDIATED ENDOCYTOSIS; PORE EXPANSION; ACTIN-FILAMENTS; MOTILITY
   DRIVEN; CELL FUSION; MYOSIN-II; CURVATURE; DYNAMIN; HEMIFUSION;
   MECHANICS
AB Diverse cell biological processes that involve shaping and remodeling of cell membranes are regulated by membrane lateral tension. Here we focus on the role of tension in driving membrane fusion. We discuss the physics of membrane tension, forces that can generate the tension in plasma membrane of a cell, and the hypothesis that tension powers expansion of membrane fusion pores in late stages of cell-to-cell and exocytotic fusion. We propose that fusion pore expansion can require unusually large membrane tensions or, alternatively, low line tensions of the pore resulting from accumulation in the pore rim of membrane-bending proteins. Increase of the inter-membrane distance facilitates the reaction.
C1 [Kozlov, Michael M.] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel.
   [Chernomordik, Leonid V.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Membrane Biol, Program Phys Biol, NIH, Bethesda, MD 20892 USA.
RP Kozlov, MM (reprint author), Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel.
EM michk@post.tau.ac.il; chernoml@mail.nih.gov
FU Israel Science Foundation (ISF); Intramural Research Program of the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health
FX M.M.K. is supported by the Israel Science Foundation (ISF), and holds
   the Joseph Klafter Chair in Biophysics. The research of L.V.C. is
   supported by the Intramural Research Program of the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development,
   National Institutes of Health.
NR 54
TC 9
Z9 9
U1 5
U2 21
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-440X
EI 1879-033X
J9 CURR OPIN STRUC BIOL
JI Curr. Opin. Struct. Biol.
PD AUG
PY 2015
VL 33
BP 61
EP 67
DI 10.1016/j.sbi.2015.07.010
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CX0BR
UT WOS:000365362400009
PM 26282924
ER

PT J
AU Nieman, LK
   Biller, BMK
   Findling, JW
   Murad, MH
   Newell-Price, J
   Savage, MO
   Tabarin, A
AF Nieman, Lynnette K.
   Biller, Beverly M. K.
   Findling, James W.
   Murad, M. Hassan
   Newell-Price, John
   Savage, Martin O.
   Tabarin, Antoine
TI Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice
   Guideline
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID QUALITY-OF-LIFE; LONG-TERM REMISSION; MACRONODULAR ADRENAL-HYPERPLASIA;
   ADRENOCORTICOTROPIC HORMONE SYNDROME; GLUCOCORTICOID-INDUCED
   OSTEOPOROSIS; DOPAMINE-RECEPTOR EXPRESSION; MEDULLARY-THYROID CARCINOMA;
   MCCUNE-ALBRIGHT SYNDROME; LOW-DOSE ETOMIDATE; TRANSSPHENOIDAL SURGERY
AB Objective: The objective is to formulate clinical practice guidelines for treating Cushing's syndrome.
   Participants: Participants include an Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer. The European Society for Endocrinology co-sponsored the guideline.
   Evidence: The Task Force used the Grading of Recommendations, Assessment, Development, and Evaluation system to describe the strength of recommendations and the quality of evidence. The Task Force commissioned three systematic reviews and used the best available evidence from other published systematic reviews and individual studies.
   Consensus Process: The Task Force achieved consensus through one group meeting, several conference calls, and numerous e-mail communications. Committees and members of The Endocrine Society and the European Society of Endocrinology reviewed and commented on preliminary drafts of these guidelines.
   Conclusions: Treatment of Cushing's syndrome is essential to reduce mortality and associated comorbidities. Effective treatment includes the normalization of cortisol levels or action. It also includes the normalization of comorbidities via directly treating the cause of Cushing's syndrome and by adjunctive treatments (eg, antihypertensives). Surgical resection of the causal lesion(s) is generally the first-line approach. The choice of second-line treatments, including medication, bilateral adrenalectomy, and radiation therapy (for corticotrope tumors), must be individualized to each patient.
C1 [Nieman, Lynnette K.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Biller, Beverly M. K.] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA.
   [Findling, James W.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Murad, M. Hassan] Mayo Clin, Div Prevent Med, Rochester, MN 55905 USA.
   [Newell-Price, John] Univ Sheffield, Dept Human Metab, Sch Med & Biomed Sci, Sheffield S10 2RX, S Yorkshire, England.
   [Savage, Martin O.] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England.
   [Tabarin, Antoine] Ctr Hosp Univ Bordeaux, Dept Endocrinol, F-33077 Bordeaux, France.
   Univ Bordeaux, Inserm 862, F-33077 Bordeaux, France.
RP Nieman, LK (reprint author), Endocrine Soc, 2055 L St NW,Suite 600, Washington, DC 20036 USA.
EM govt-prof@endocrine.org
FU Intramural Research Program of the Eunice Kennedy Shriver Institute of
   Child Health and Human Development
FX The Intramural Research Program of the Eunice Kennedy Shriver Institute
   of Child Health and Human Development provided salary support to Dr
   Nieman for her work on this manuscript.
NR 212
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Z9 62
U1 6
U2 11
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 2807
EP 2831
DI 10.1210/jc.2015-1818
PG 25
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900019
PM 26222757
ER

PT J
AU Taylor, SI
   Blau, JE
   Rother, KI
AF Taylor, Simeon I.
   Blau, Jenny E.
   Rother, Kristina I.
TI SGLT2 Inhibitors May Predispose to Ketoacidosis
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID COTRANSPORTER 2 INHIBITION; DIABETES-MELLITUS; DOUBLE-BLIND; GLUCOSE;
   DAPAGLIFLOZIN; TRANSPORTER; OXIDATION; SECRETION; BRAIN; RATS
AB Context: Sodium glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic drugs that increase urinary excretion of glucose, thereby improving glycemic control and promoting weight loss. Since approval of the first-in-class drug in 2013, data have emerged suggesting that these drugs increase the risk of diabetic ketoacidosis. In May 2015, the Food and Drug Administration issued a warning that SGLT2 inhibitors may lead to ketoacidosis.
   Evidence Acquisition: Using PubMed and Google, we conducted Boolean searches including terms related to ketone bodies or ketoacidosis with terms for SGLT2 inhibitors or phlorizin. Priority was assigned to publications that shed light on molecular mechanisms whereby SGLT2 inhibitors could affect ketone body metabolism.
   Evidence Synthesis: SGLT2 inhibitors trigger multiple mechanisms that could predispose to diabetic ketoacidosis. When SGLT2 inhibitors are combined with insulin, it is often necessary to decrease the insulin dose to avoid hypoglycemia. The lower dose of insulin may be insufficient to suppress lipolysis and ketogenesis. Furthermore, SGLT2 is expressed in pancreatic alpha-cells, and SGLT2 inhibitors promote glucagon secretion. Finally, phlorizin, a nonselective inhibitor of SGLT family transporters decreases urinary excretion of ketone bodies. A decrease in the renal clearance of ketone bodies could also increase the plasma ketone body levels.
   Conclusions: Based on the physiology of SGLT2 and the pharmacology of SGLT2 inhibitors, there are several biologically plausible mechanisms whereby this class of drugs has the potential to increase the risk of developing diabetic ketoacidosis. Future research should be directed toward identifying which patients are at greatest risk for this side effect and also to optimizing pharmacotherapy to minimize the risk to patients.
C1 [Taylor, Simeon I.; Blau, Jenny E.; Rother, Kristina I.] NIDDK, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD 20892 USA.
   [Taylor, Simeon I.] Univ Maryland, Sch Med, Div Diabet Endocrinol & Nutr, Dept Med, Baltimore, MD 21201 USA.
RP Taylor, SI (reprint author), NIDDK, Diabet Endocrinol & Obes Branch, NIH, Mail Stop 1453,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM simeon.taylor@nih.gov
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [2P30DK072488, 1R21DK105401]; Intramural Research Programs of the
   National Institute of Diabetes and Digestive and Kidney Diseases; Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
FX Dr. Taylor acknowledges support from the following two grants from the
   National Institute of Diabetes and Digestive and Kidney Diseases to the
   University of Maryland School of Medicine: 2P30DK072488 and
   1R21DK105401.; This work was supported by the Intramural Research
   Programs of the National Institute of Diabetes and Digestive and Kidney
   Diseases and the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development.
NR 16
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Z9 71
U1 3
U2 14
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 2849
EP 2852
DI 10.1210/jc.2015-1884
PG 4
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900023
PM 26086329
ER

PT J
AU Sjaarda, LA
   Schisterman, EF
   Schliep, KC
   Plowden, T
   Zarek, SM
   Yeung, E
   Wactawski-Wende, J
   Mumford, SL
AF Sjaarda, Lindsey A.
   Schisterman, Enrique F.
   Schliep, Karen C.
   Plowden, Torie
   Zarek, Shvetha M.
   Yeung, Edwina
   Wactawski-Wende, Jean
   Mumford, Sunni L.
TI Dietary Carbohydrate Intake Does Not Impact Insulin Resistance or
   Androgens in Healthy, Eumenorrheic Women
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; LIFE-STYLE MODIFICATION; LOW-GLYCEMIC-LOAD;
   LOW-FAT DIET; MENSTRUAL-CYCLE; PREMENOPAUSAL WOMEN; SYNDROME PCOS; OBESE
   WOMEN; SENSITIVITY; METFORMIN
AB Context: Diet is proposed to contribute to androgen-related reproductive dysfunction.
   Objective: This study evaluated the association between dietary macronutrient intake, carbohydrate fraction intake, and overall diet quality on androgens and related hormones, including anti-Mullerian (AMH) and insulin, in healthy, regularly menstruating women.
   Design: This was a prospective cohort study from 2005 and 2007.
   Setting: The study was conducted at the University at Buffalo, western New York State, USA.
   Participants: Participants were 259 eumenorrheic women without a self-reported history of infertility, polycystic ovary syndrome (PCOS), or other endocrine disorder.
   Main Outcome Measures: A 24-hour dietary recall was administered 4 times per menstrual cycle, and hormones were measured 5 to 8 times per cycle for 1 (n = 9) or 2 (n = 250) cycles per woman (n = 509 cycles). Associations between the dietary intake of carbohydrates (starch, sugar, sucrose, and fiber), macronutrients, overall diet quality and hormones (insulin, AMH, and total and free testosterone), as well as the relationship of dietary intake with occurrences of high total testosterone combined with high AMH (fourth quartile of each), ie, the "PCOS-like phenotype," were assessed.
   Results: No significant relationships were identified between dietary intake of carbohydrates, percent calories from any macronutrient or overall diet quality (ie, Mediterranean diet score) and relevant hormones (insulin, AMH, and total and free testosterone). Likewise, no significant relationships were identified between dietary factors and the occurrence of a subclinical PCOS-like phenotype.
   Conclusions: Despite evidence of a subclinical continuum of a PCOS-related phenotype of elevated androgens and AMH related to sporadic anovulation identified in previous studies, dietary carbohydrate and diet quality do not appear to relate to these subclinical endocrine characteristics in women without overt PCOS.
C1 [Sjaarda, Lindsey A.; Schisterman, Enrique F.; Schliep, Karen C.; Plowden, Torie; Zarek, Shvetha M.; Yeung, Edwina; Mumford, Sunni L.] Eunice Kennedy Sbriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, NIH, Bethesda, MD 20892 USA.
   [Plowden, Torie; Zarek, Shvetha M.] Eunice Kennedy Sbriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Wactawski-Wende, Jean] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14214 USA.
RP Sjaarda, LA (reprint author), Eunice Kennedy Sbriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, 6100 Execut Blvd Room 71103, Bethesda, MD 20892 USA.
EM lindsey.sjaarda@nih.gov
RI Yeung, Edwina/F-5992-2015; 
OI Yeung, Edwina/0000-0002-3851-2613; Sjaarda, Lindsey/0000-0003-0539-8110;
   Schisterman, Enrique/0000-0003-3757-641X
FU Intramural Research Program of the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, National Institutes of
   Health [HHSN275200403394C, HHSN275201100002I Task 1 HHSN27500001]
FX This work was supported by the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health (Contract HHSN275200403394C
   and Contract HHSN275201100002I Task 1 HHSN27500001). The funding source
   had no role in the study design, data gathering, analysis and
   interpretation, writing of the report, or the decision to submit the
   report for publication. The corresponding author had full access to all
   of the data and the final responsibility to submit the report for
   publication.
NR 37
TC 3
Z9 3
U1 2
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 2979
EP 2986
DI 10.1210/jc.2015-1957
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900040
PM 26066675
ER

PT J
AU Piaggi, P
   Thearle, MS
   Krakoff, J
   Votruba, SB
AF Piaggi, Paolo
   Thearle, Marie S.
   Krakoff, Jonathan
   Votruba, Susanne B.
TI Higher Daily Energy Expenditure and Respiratory Quotient, Rather Than
   Fat-Free Mass, Independently Determine Greater ad Libitum Overeating
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID RESTING METABOLIC-RATE; BODY-COMPOSITION; FOOD-INTAKE; WEIGHT
   REGULATION; APPETITE CONTROL; FUEL UTILIZATION; OXIDATION RATE; MEAL
   SIZE; CARBOHYDRATE; BALANCE
AB Context: Body fat-free mass (FFM), energy expenditure (EE), and respiratory quotient (RQ) are known predictors of daily food intake. Because FFM largely determines EE, it is unclear whether body composition per se or the underlying metabolism drives dietary intake.
   Objective: The objective of the study was to test whether 24-hour measures of EE and RQ and their components influence ad libitum food intake independently of FFM.
   Design and Participants: One hundred seven healthy individuals (62 males/45 females, 84 Native Americans/23 whites; age 33 +/- 8 y; body mass index 33 +/- 8 kg/m(2); body fat 31% +/- 8%) had 24-hour measures of EE in a whole-room indirect calorimeter during energy balance, followed by 3 days of ad libitum food intake using computerized vending machine systems. Body composition was estimated by dual-energy x-ray absorptiometry.
   Main Outcome Measures: FFM, 24-hour EE, RQ, spontaneous physical activity, sleeping EE (sleeping metabolic rate), awake and fed thermogenesis, and ad libitum food intake (INTAKE) were measured.
   Results: Higher 24-hour RQ (P < .001, partial R-2 = 16%) and EE (P = .01, partial R-2 = 7%), but not FFM (P = .65), were independent predictors of INTAKE. Mediation analysis demonstrated that 24-hour EE is responsible for 80% of the FFM effect on INTAKE (44.5 +/- 16.9 kcal ingested per kilogram of FFM, P = .01), whereas the unique effect due to solely FFM was negligible (10.6 +/- 23.2, P = .65). Spontaneous physical activity (r = 0.33, P = .001), but not sleeping metabolic rate (P = .71), positively predicted INTAKE, whereas higher awake and fed thermogenesis determined greater INTAKE only in subjects with a body mass index of 29 kg/m(2) or less (r = 0.44, P = .01).
   Conclusions: EE and RQ, rather than FFM, independently determine INTAKE, suggesting that competitive energy-sensing mechanisms driven by the preferential macronutrient oxidation and total energy demands may regulate food intake.
C1 [Piaggi, Paolo; Thearle, Marie S.; Krakoff, Jonathan; Votruba, Susanne B.] NIDDKD, Obes & Diabet Clin Res Sect, NIH, Phoenix, AZ 85016 USA.
   [Piaggi, Paolo] Univ Hosp Pisa, Endocrinol Unit, Obes Res Ctr, I-56124 Pisa, Italy.
RP Piaggi, P (reprint author), NIDDKD, Phoenix Epidemiol & Clin Res Branch, NIH, 4212 N 16th St, Phoenix, AZ 85016 USA.
EM paolo.piaggi@gmail.com
OI Piaggi, Paolo/0000-0003-2774-9161
FU National Institutes of Health, National Institute of Diabetes and
   Digestive and Kidney Diseases; National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institutes of Health
FX This work was supported by the Intramural Research Program of the
   National Institutes of Health, National Institute of Diabetes and
   Digestive and Kidney Diseases. P.P. was supported by a visiting
   fellowship award of the National Institute of Diabetes and Digestive and
   Kidney Diseases, National Institutes of Health.
NR 30
TC 3
Z9 3
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 3011
EP 3020
DI 10.1210/jc.2015-2164
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900044
PM 26086330
ER

PT J
AU Muniyappa, R
   Noureldin, R
   Ouwerkerk, R
   Liu, EY
   Madan, R
   Abel, BS
   Mullins, K
   Walter, MF
   Skarulis, MC
   Gharib, AM
AF Muniyappa, Ranganath
   Noureldin, Radwa
   Ouwerkerk, Ronald
   Liu, Elizabeth Y.
   Madan, Ritu
   Abel, Brent S.
   Mullins, Katherine
   Walter, Mary F.
   Skarulis, Monica C.
   Gharib, Ahmed M.
TI Myocardial Fat Accumulation Is Independent of Measures of Insulin
   Sensitivity
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID METABOLIC SYNDROME; DIABETES-MELLITUS; EPICARDIAL FAT;
   RESONANCE-SPECTROSCOPY; DIASTOLIC DYSFUNCTION; TRIGLYCERIDE CONTENT;
   CARDIAC STEATOSIS; ACID-METABOLISM; HEART-FAILURE; LIPID-CONTENT
AB Background: Myocardial steatosis, an independent predictor of diastolic dysfunction, is frequently present in type 2 diabetes mellitus. High free fatty acid flux, hyperglycemia, and hyperinsulinemia may play a role in myocardial steatosis. There are no prior studies examining the relationship between insulin sensitivity (antilipolytic and glucose disposal actions of insulin) and cardiac steatosis.
   Objective: Using a cross-sectional study design of individuals with and without metabolic syndrome (MetSyn), we examined the relationships between cardiac steatosis and the sensitivity of the antilipolytic and glucose disposal actions of insulin.
   Methods: Pericardial fat (PF) volume, intramyocardial and hepatic fat (MF and HF) content, visceral fat (VF) and sc fat content were assessed by magnetic resonance imaging in 77 subjects (49 without MetSyn and 28 with MetSyn). In a subset of the larger cohort (n = 52), peripheral insulin sensitivity index (S-I) and adipocyte insulin sensitivity (Adipo-S-I) were determined from an insulin-modified frequently sampled iv glucose tolerance test. The Quantitative Insulin Sensitivity Check Index was used as a surrogate for hepatic insulin sensitivity.
   Results: Individuals with the MetSyn had significantly higher body mass index, total body fat, and MF, PF, HF, and VF content. HF and VF, but not MF, were negatively correlated with the Quantitative Insulin Sensitivity Check Index, Adipo-S-I, and S-I. Stepwise regression revealed that waist circumference and serum triglyceride levels independently predicted MF and PF, respectively. Adipo-S-I and serum triglyceride levels independently predict HF.
   Conclusion: Myocardial steatosis is unrelated to hepatic, adipocyte, or peripheral insulin sensitivity. Although it is frequently observed in insulin-resistant subjects, further studies are necessary to identify and delineate pathogenic mechanisms that differentially affect cardiac and hepatic steatosis.
C1 [Muniyappa, Ranganath; Liu, Elizabeth Y.; Madan, Ritu; Abel, Brent S.; Mullins, Katherine; Walter, Mary F.; Skarulis, Monica C.] NIDDKD, Diabet Endocrinol & Obes Branch, Bethesda, MD 20892 USA.
   [Noureldin, Radwa; Ouwerkerk, Ronald; Gharib, Ahmed M.] NIDDKD, Biomed & Metab Imaging Branch, Bethesda, MD 20892 USA.
RP Muniyappa, R (reprint author), NIDDKD, Clin Endocrine Sect, Diabet Endocrinol & Obes Branch, NIH,CRC, 10 Ctr Dr,MSC 1613,Bldg 10,Room 5-3672, Bethesda, MD 20892 USA.
EM muniyapr@mail.nih.gov
RI Gharib, Ahmed/O-2629-2016
OI Gharib, Ahmed/0000-0002-2476-481X
FU Intramural Research Program of the National Institute of Diabetes and
   Digestive and Kidney Diseases
FX This work was supported by the Intramural Research Program of the
   National Institute of Diabetes and Digestive and Kidney Diseases.
NR 42
TC 2
Z9 2
U1 0
U2 0
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 3060
EP 3068
DI 10.1210/jc.2015-1139
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900049
PM 26020762
ER

EF