FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Kaur, G
   Reinhart, RA
   Monks, A
   Evans, D
   Morris, J
   Teicher, BA
AF Kaur, Gurmeet
   Reinhart, Russell A.
   Monks, Anne
   Evans, David
   Morris, Joel
   Teicher, Beverly A.
TI Bromodomain and hegdehog pathway targets in small cell lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kaur, Gurmeet] NCI, Frederick, MD 21701 USA.
   [Reinhart, Russell A.; Monks, Anne; Evans, David] Leidos Biomed Res Inc, Frederick, MD USA.
   [Morris, Joel; Teicher, Beverly A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5508
DI 10.1158/1538-7445.AM2014-5508
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204424
ER

PT J
AU Kawabata, S
   Chiang, CT
   Memmott, RM
   Komiya, T
   Gills, JJ
   Dennis, PA
AF Kawabata, Shigeru
   Chiang, Chun-Te
   Memmott, Regan M.
   Komiya, Takefumi
   Gills, Joell J.
   Dennis, Phillip A.
TI Rapamycin decreases expression of thymidylate synthase and enhances the
   response to pemetrexed in preclinical studies and a Phase I/II clinical
   study of subjects with non-small cell lung cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kawabata, Shigeru; Memmott, Regan M.; Gills, Joell J.; Dennis, Phillip A.] Johns Hopkins Univ, Baltimore, MD USA.
   [Chiang, Chun-Te; Komiya, Takefumi] NCI, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2927
DI 10.1158/1538-7445.AM2014-2927
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904196
ER

PT J
AU Kedei, N
   Michalowski, AM
   Blumberg, PM
AF Kedei, Noemi
   Michalowski, Aleksandra M.
   Blumberg, Peter M.
TI Transient duration of action is the primary mechanism responsible for
   the unique biology of bryostatin 1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kedei, Noemi; Michalowski, Aleksandra M.; Blumberg, Peter M.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3195
DI 10.1158/1538-7445.AM2014-3195
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200199
ER

PT J
AU Keeley, BR
   Islami, F
   Pourshams, A
   Poustchi, H
   Pak, JS
   Brennan, P
   Khademi, H
   Chen, SH
   Genden, EM
   Abnet, CC
   Dawsey, SM
   Boffetta, P
   Malekzadeh, R
   Sikora, AG
AF Keeley, Brieze R.
   Islami, Farhad
   Pourshams, Akram
   Poustchi, Hossein
   Pak, Jamie S.
   Brennan, Paul
   Khademi, Hooman
   Chen, Shu-hsia
   Genden, Eric M.
   Abnet, Christian C.
   Dawsey, Sanford M.
   Boffetta, Paolo
   Malekzadeh, Reza
   Sikora, Andrew G.
TI Serum inflammatory biomarkers predict esophageal and lung cancer risk
   two years prior to diagnosis in a prospective cohort
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Keeley, Brieze R.; Islami, Farhad; Pak, Jamie S.; Chen, Shu-hsia; Genden, Eric M.; Boffetta, Paolo; Sikora, Andrew G.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Pourshams, Akram; Poustchi, Hossein; Khademi, Hooman; Malekzadeh, Reza] Univ Tehran Med Sci, Tehran, Iran.
   [Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
   [Abnet, Christian C.; Dawsey, Sanford M.] NCI, Bethesda, MD 20892 USA.
RI Abnet, Christian/C-4111-2015
OI Abnet, Christian/0000-0002-3008-7843
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 890
DI 10.1158/1538-7445.AM2014-890
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905350
ER

PT J
AU Kelly, PN
   Chaudhary, D
   Young, RM
   Shaffer, A
   Robinson, S
   Romero, DL
   Kapeller, R
   Staudt, LM
AF Kelly, Priscilla N.
   Chaudhary, Divya
   Young, Ryan M.
   Shaffer, Art
   Robinson, Shaughnessy
   Romero, Donna L.
   Kapeller, Rosana
   Staudt, Louis M.
TI Highly potent and selective interleukin-1 receptor-associated kinase 4
   inhibitors for the therapy of lymphoid malignancies
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kelly, Priscilla N.; Young, Ryan M.; Shaffer, Art; Staudt, Louis M.] Natl Canc Inst, Bethesda, MD USA.
   [Chaudhary, Divya; Romero, Donna L.; Kapeller, Rosana] Nimbus Discovery, Cambridge, MA USA.
   [Robinson, Shaughnessy] Schrodinger, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-112
DI 10.1158/1538-7445.AM2014-LB-112
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205148
ER

PT J
AU Kelsey, J
   Kedei, N
   Cataisson, C
   Petersen, M
   Yuspa, S
   Keck, G
   Blumberg, P
AF Kelsey, Jessica
   Kedei, Noemi
   Cataisson, Christophe
   Petersen, Mark
   Yuspa, Stuart
   Keck, Gary
   Blumberg, Peter
TI Bryostatin 1 and the simplified analog Merle 23 have similar and
   opposing properties on mouse epidermal cells and mouse skin
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kelsey, Jessica; Kedei, Noemi; Cataisson, Christophe; Yuspa, Stuart; Blumberg, Peter] NCI, Bethesda, MD 20892 USA.
   [Petersen, Mark; Keck, Gary] Univ Utah, Salt Lake City, UT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1642
DI 10.1158/1538-7445.AM2014-1642
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901364
ER

PT J
AU Kiesel, B
   Parise, R
   Lin, Y
   Allen, D
   Reddy, G
   Chawla, S
   Piekarz, R
   Ivy, P
   Kumar, S
   Beumer, JH
AF Kiesel, Brian
   Parise, Robert
   Lin, Yan
   Allen, Deborah
   Reddy, Guru
   Chawla, Shanta
   Piekarz, Richard
   Ivy, Percy
   Kumar, Shivaani
   Beumer, Jan H.
TI Pharmacokinetic analysis of the HDAC inhibitor belinostat (PXD-101) and
   metabolites in patients with hepatic dysfunction
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kiesel, Brian; Parise, Robert; Lin, Yan; Beumer, Jan H.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Allen, Deborah; Kumar, Shivaani] NCI, NIH, Bethesda, MD 20892 USA.
   [Reddy, Guru; Chawla, Shanta] Spectrum Pharmaceut, Irvine, CA USA.
   [Piekarz, Richard; Ivy, Percy] NCI, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA CT207
DI 10.1158/1538-7445.AM2014-CT207
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205036
ER

PT J
AU Kim, C
   Shu, XO
   Hosgood, HD
   Bassig, BA
   Seow, WJ
   Xiang, YB
   Ji, BT
   Hu, W
   Chow, WH
   Gao, YT
   Rothman, N
   Lan, Q
AF Kim, Christopher
   Shu, Xiao-Ou
   Hosgood, H. Dean
   Bassig, Bryan A.
   Seow, Wei Jie
   Xiang, Yongbin
   Ji, Bu-Tian
   Hu, Wei
   Chow, Wong-Ho
   Gao, Yutang
   Rothman, Nathaniel
   Lan, Qing
TI Past use of coal for cooking is associated with all-cause mortality in
   the prospective Shanghai Women's Health Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Christopher; Bassig, Bryan A.; Seow, Wei Jie; Ji, Bu-Tian; Hu, Wei; Rothman, Nathaniel; Lan, Qing] NCI, Bethesda, MD 20892 USA.
   [Shu, Xiao-Ou] Vanderbilt Univ, Nashville, TN 37235 USA.
   [Hosgood, H. Dean] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Xiang, Yongbin; Gao, Yutang] Shanghai Canc Inst, Shanghai, Peoples R China.
   [Chow, Wong-Ho] Univ Texas Houston, Houston, TX USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2184
DI 10.1158/1538-7445.AM2014-2184
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902395
ER

PT J
AU Kim, JH
   Qu, A
   Reddy, JK
   Gao, B
   Gonzalez, FJ
AF Kim, Jung-Hwan
   Qu, Aijuan
   Reddy, Janardan K.
   Gao, Bin
   Gonzalez, Frank J.
TI Hepatic oxidative stress activates the Gadd45b gene via degradation of
   the transcriptional repressor STAT3
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Jung-Hwan; Qu, Aijuan; Gonzalez, Frank J.] NCI, Bethesda, MD 20892 USA.
   [Reddy, Janardan K.] Northwestern Univ, Feiberg Sch Med, Evanston, IL 60208 USA.
   [Gao, Bin] NIAAA, Lab Liver Dis, Rockville, MD 20852 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 492
DI 10.1158/1538-7445.AM2014-492
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904456
ER

PT J
AU Kim, MKH
   Min, DJ
   Wright, G
   Annunziata, CM
AF Kim, Marianne K. H.
   Min, Dong Joon
   Wright, George
   Annunziata, Christina M.
TI Context-specific dependence of ovarian cancer on IKK epsilon and CHEK1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Marianne K. H.; Min, Dong Joon; Wright, George; Annunziata, Christina M.] NCI, Bethesda, MD 20892 USA.
RI Annunziata, Christina/L-3219-2016
OI Annunziata, Christina/0000-0003-2033-6532
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5179
DI 10.1158/1538-7445.AM2014-5179
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204130
ER

PT J
AU Kim, PS
   Jochems, C
   Grenga, I
   Donahue, RN
   Tsang, KY
   Gulley, JL
   Schlom, J
   Farsaci, B
AF Kim, Peter S.
   Jochems, Caroline
   Grenga, Italia
   Donahue, Renee N.
   Tsang, Kwong Y.
   Gulley, James L.
   Schlom, Jeffrey
   Farsaci, Benedetto
TI Pan-Bcl-2 inhibitor, GX15-070 (Obatoclax), decreases human T regulatory
   lymphocytes while preserving effector T Lymphocytes: A rationale for its
   use in combination immunotherapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Peter S.; Jochems, Caroline; Grenga, Italia; Donahue, Renee N.; Tsang, Kwong Y.; Gulley, James L.; Schlom, Jeffrey; Farsaci, Benedetto] NCI, NIH, Bethesda, MD 20892 USA.
RI Farsaci, Benedetto/L-9837-2014; Gulley, James/K-4139-2016
OI Farsaci, Benedetto/0000-0001-8275-2561; Gulley,
   James/0000-0002-6569-2912
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 628
DI 10.1158/1538-7445.AM2014-628
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905090
ER

PT J
AU Kim, S
   Varticovski, L
   Grontved, L
   Baek, S
   Thompson, B
   Dean, M
   Theodoresco, D
   Nickerson, ML
   Hager, GL
AF Kim, Sohyoung
   Varticovski, Lyuba
   Grontved, Lars
   Baek, Songjoon
   Thompson, Bethrice
   Dean, Michael
   Theodoresco, Daniel
   Nickerson, Michael L.
   Hager, Gordon L.
TI Changes in global chromatin landscape identify bladder cancer
   progression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Sohyoung; Varticovski, Lyuba; Grontved, Lars; Baek, Songjoon; Dean, Michael; Nickerson, Michael L.; Hager, Gordon L.] NCI CCR, Bethesda, MD USA.
   [Thompson, Bethrice] Howard Univ, Washington, DC 20059 USA.
   [Theodoresco, Daniel] UC Denver, Denver, CO USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 474
DI 10.1158/1538-7445.AM2014-474
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904438
ER

PT J
AU Kim, S
   Grohar, PJ
   Klumpp, C
   Lal, A
   Martin, SE
   Helman, LJ
   Caplen, NJ
AF Kim, Suntae
   Grohar, Patrick J.
   Klumpp, Carleen
   Lal, Ashish
   Martin, Scott E.
   Helman, Lee J.
   Caplen, Natasha J.
TI Functional genomic screens identify microRNA regulators of the oncogenic
   fusion transcription factor EWS-FLI1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kim, Suntae; Caplen, Natasha J.] NCI, Gene Silencing Sect, Genet Branch, CCR,NIH, Bethesda, MD 20892 USA.
   [Grohar, Patrick J.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
   [Klumpp, Carleen; Martin, Scott E.] NIH, Trans NIH RNAi Facil, NCATS, Bethesda, MD 20892 USA.
   [Lal, Ashish] NCI, Regulatory RNAs & Canc Sect, Genet Branch, CCR,NIH, Bethesda, MD 20892 USA.
   [Helman, Lee J.] NCI, Pediat Oncol Branch, CCR, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 520
DI 10.1158/1538-7445.AM2014-520
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904483
ER

PT J
AU Kinders, RJ
   Hollingshead, M
   Thottassery, J
   Parker, WB
   Pfister, TD
   Anderson, LW
   Tomaszewski, JE
   Collins, JM
   Doroshow, JH
AF Kinders, Robert J.
   Hollingshead, Melinda
   Thottassery, Jaideep
   Parker, William B.
   Pfister, Thomas D.
   Anderson, Lawrence W.
   Tomaszewski, Joseph E.
   Collins, Jerry M.
   Doroshow, James H.
TI Pre-clinical development of 4 '-thio-2 '-deoxycytidine (TdCyd) as a
   DNA-demethylating agent for use in treating solid tissue tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kinders, Robert J.; Pfister, Thomas D.] Frederick Natl Lab Canc Res, LHTP, ADRD, Leidos Biomed Res Inc, Frederick, MD USA.
   [Hollingshead, Melinda] Frederick Natl Lab Canc Res, Biol Testing Branch, Frederick, MD USA.
   [Thottassery, Jaideep; Parker, William B.] So Res Inst, Birmingham, AL 35255 USA.
   [Anderson, Lawrence W.; Collins, Jerry M.] NCI, Dev Therapeut Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2306
DI 10.1158/1538-7445.AM2014-2306
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903025
ER

PT J
AU Kines, R
   Bhattacharya, D
   MacDougall, JR
   Milenic, D
   Brechbiel, MW
   de los Pinos, E
   Schiller, JT
AF Kines, Rhonda
   Bhattacharya, Debaditya
   MacDougall, John R.
   Milenic, Diane
   Brechbiel, Martin W.
   de los Pinos, Elisabet
   Schiller, John T.
TI Viral-based nanoparticles: a new therapeutic approach for anticancer
   therapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kines, Rhonda; Bhattacharya, Debaditya; MacDougall, John R.; de los Pinos, Elisabet] Aura Biosci, Cambridge, MA USA.
   [Milenic, Diane; Brechbiel, Martin W.] NCI, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA.
   [Schiller, John T.] NCI, Cellular Oncol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1770
DI 10.1158/1538-7445.AM2014-1770
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901490
ER

PT J
AU Kobayashi, H
   Sano, K
   Nakajima, T
   Sato, K
   Choyke, PL
AF Kobayashi, Hisataka
   Sano, Kohei
   Nakajima, Takahito
   Sato, Kazuhide
   Choyke, Peter L.
TI Photoimmunotherapy (PIT) combined with a nanosized cancer agent
   successfully treated heterogenous antigen-expressing tumors based on
   super-enhanced permeability and retention (SUPR) effect
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kobayashi, Hisataka; Sano, Kohei; Nakajima, Takahito; Sato, Kazuhide; Choyke, Peter L.] NCI, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 3
U2 5
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5400
DI 10.1158/1538-7445.AM2014-5400
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204318
ER

PT J
AU Kocarnik, JM
   Passarelli, MN
   Phipps, AI
   Chan, AT
   Gala, M
   Joshi, A
   Campbell, PT
   Slattery, ML
   Potter, J
   White, E
   Berndt, S
   Peters, U
   Newcomb, PA
AF Kocarnik, Jonathan M.
   Passarelli, Michael N.
   Phipps, Amanda I.
   Chan, Andrew T.
   Gala, Manish
   Joshi, Amit
   Campbell, Peter T.
   Slattery, Martha L.
   Potter, John
   White, Emily
   Berndt, Sonja
   Peters, Ulrike
   Newcomb, Polly A.
TI Colorectal cancer survival is not associated with genetic variants
   related to risk of other cancers: The GECCO study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kocarnik, Jonathan M.; Passarelli, Michael N.; Phipps, Amanda I.; Potter, John; White, Emily; Peters, Ulrike; Newcomb, Polly A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Chan, Andrew T.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Gala, Manish] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Joshi, Amit] Harvard Univ, Boston, MA 02115 USA.
   [Campbell, Peter T.] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Slattery, Martha L.] Univ Utah Hlth Sci Ctr, Salt Lake City, UT USA.
   [Berndt, Sonja] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2187
DI 10.1158/1538-7445.AM2014-2187
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902398
ER

PT J
AU Kuo, CT
   Wang, HT
   Chen, JH
   Siddiqui, J
   Young, MR
   Saud, S
   Stoner, G
   Wang, LS
AF Kuo, Chieh-Ti
   Wang, Hsin-Tzu
   Chen, Jo-Hsin
   Siddiqui, Jibran
   Young, Matthew R.
   Saud, Shakir
   Stoner, Gary
   Wang, Li-Shu
TI Black raspberries and protocatechuic acid protectively alter gut
   bacteria and bile acid metabolism in Apc(Min/+) mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Kuo, Chieh-Ti; Wang, Hsin-Tzu; Chen, Jo-Hsin; Siddiqui, Jibran; Stoner, Gary; Wang, Li-Shu] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Young, Matthew R.; Saud, Shakir] NCI, NIH, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2134
DI 10.1158/1538-7445.AM2014-2134
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902346
ER

PT J
AU Lam, TK
   Chang, CQ
   Rogers, SD
   Khoury, MJ
   Schully, SD
AF Lam, Tram K.
   Chang, Christine Q.
   Rogers, Scott D.
   Khoury, Muin J.
   Schully, Sheri D.
TI How can epidemiology become more effective in reducing the burden of
   cancer in the 21st century? An analysis of NCI-funded grants and the
   scientific literature
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lam, Tram K.; Chang, Christine Q.; Rogers, Scott D.; Khoury, Muin J.; Schully, Sheri D.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 254
DI 10.1158/1538-7445.AM2014-254
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903277
ER

PT J
AU Landi, MT
   Wang, YF
   Mckay, JD
   Rafnar, T
   Wang, ZM
   Timofeeva, M
   Broderick, P
   Stefansson, K
   Risch, A
   Chanock, SJ
   Christiani, DC
   Hung, RJ
   Brennan, P
   Houlston, RS
   Amos, CI
AF Landi, Maria Teresa
   Wang, Yufei
   Mckay, James D.
   Rafnar, Thorunn
   Wang, Zhaoming
   Timofeeva, Maria
   Broderick, Peter
   Stefansson, Kari
   Risch, Angela
   Chanock, Stephen J.
   Christiani, David C.
   Hung, Rayjean J.
   Brennan, Paul
   Houlston, Richard S.
   Amos, Christopher I.
TI Imputation from The 1000 Genomes Project identifies rare large effect
   variants of BRCA2-K3326X and CHEK2-I157T as risk factors for lung
   cancer; a study from the TRICL consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Landi, Maria Teresa; Wang, Zhaoming; Chanock, Stephen J.] NCI, DCEG, Bethesda, MD 20892 USA.
   [Wang, Yufei; Broderick, Peter; Houlston, Richard S.] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.
   [Mckay, James D.; Timofeeva, Maria; Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France.
   [Rafnar, Thorunn; Stefansson, Kari] Amgen Inc, deCODE Genet, Reykjavik, Iceland.
   [Risch, Angela] German Canc Res Ctr, Div Epigen & Canc Risk Factors, Heidelberg, Germany.
   [Christiani, David C.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Hung, Rayjean J.] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
   [Amos, Christopher I.] Dartmouth Coll, Geisel Sch Med, Dept Community & Family Med, Ctr Genom Med, Hanover, NH USA.
OI Houlston, Richard/0000-0002-5268-0242
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 942
DI 10.1158/1538-7445.AM2014-942
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905406
ER

PT J
AU Lane, AA
   Chapuy, B
   Lin, CY
   Tivey, T
   Li, HB
   Townsend, E
   van Bodegom, D
   Day, TA
   Wu, SC
   Liu, HY
   Yoda, A
   Alexe, G
   Schinzel, A
   Sullivan, TJ
   Malinge, S
   Taylor, J
   Stegmaier, K
   Jaffe, J
   Bustin, M
   te Kronnie, G
   Izraeli, S
   Harris, M
   Stevenson, K
   Neuberg, D
   Silverman, LB
   Sallan, SE
   Bradner, JE
   Hahn, WC
   Crispino, JD
   Pellman, D
   Weinstock, DM
AF Lane, Andrew A.
   Chapuy, Bjoern
   Lin, Charles Y.
   Tivey, Trevor
   Li, Hubo
   Townsend, Elizabeth
   van Bodegom, Diederik
   Day, Tovah A.
   Wu, Shuo-Chieh
   Liu, Huiyun
   Yoda, Akinori
   Alexe, Gabriela
   Schinzel, Anna
   Sullivan, Timothy J.
   Malinge, Sebastien
   Taylor, Jordan
   Stegmaier, Kimberly
   Jaffe, Jacob
   Bustin, Michael
   te Kronnie, Geertruy
   Izraeli, Shai
   Harris, Marian
   Stevenson, Kristen
   Neuberg, Donna
   Silverman, Lewis B.
   Sallan, Steven E.
   Bradner, James E.
   Hahn, William C.
   Crispino, John D.
   Pellman, David
   Weinstock, David M.
TI Triplication of HMGN1 promotes B cell acute lymphoblastic leukemia
   (B-ALL) through suppression of H3K27me3
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lane, Andrew A.; Chapuy, Bjoern; Lin, Charles Y.; Tivey, Trevor; Li, Hubo; Townsend, Elizabeth; van Bodegom, Diederik; Day, Tovah A.; Wu, Shuo-Chieh; Liu, Huiyun; Yoda, Akinori; Alexe, Gabriela; Schinzel, Anna; Sullivan, Timothy J.; Stegmaier, Kimberly; Stevenson, Kristen; Neuberg, Donna; Silverman, Lewis B.; Sallan, Steven E.; Bradner, James E.; Hahn, William C.; Pellman, David; Weinstock, David M.] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Malinge, Sebastien] Inst Gustave Roussy, INSERM, U985, F-94805 Villejuif, France.
   [Taylor, Jordan; Jaffe, Jacob] Broad Inst, Cambridge, MA USA.
   [Bustin, Michael] NCI, Bethesda, MD 20892 USA.
   [te Kronnie, Geertruy] Univ Padua, Padua, Italy.
   [Izraeli, Shai] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel.
   [Izraeli, Shai] Tel Aviv Univ, Tel Hashomer, Israel.
   [Harris, Marian] Childrens Hosp, Boston, MA 02115 USA.
   [Crispino, John D.] Northwestern Univ, Chicago, IL 60611 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 433
DI 10.1158/1538-7445.AM2014-433
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904398
ER

PT J
AU Lee, M
   Dworkin, AM
   Lichtenberg, J
   Patel, SJ
   Gildea, D
   Bodine, DM
   Crawford, NPS
AF Lee, Minnkyong
   Dworkin, Amy M.
   Lichtenberg, Jens
   Patel, Shashank J.
   Gildea, Derek
   Bodine, David M.
   Crawford, Nigel P. S.
TI The breast cancer metastasis suppressor RRP1B modulates metastasis
   through regulation of histone methylation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lee, Minnkyong; Dworkin, Amy M.; Lichtenberg, Jens; Patel, Shashank J.; Gildea, Derek; Bodine, David M.; Crawford, Nigel P. S.] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 123
DI 10.1158/1538-7445.AM2014-123
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900122
ER

PT J
AU Lee, YH
   Apolo, A
   Agarwal, PK
   Bottaro, DP
AF Lee, Young H.
   Apolo, Andrea
   Agarwal, Piyush K.
   Bottaro, Donald P.
TI Characterization of Met signaling in urothelial cancer of the bladder
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lee, Young H.; Apolo, Andrea; Agarwal, Piyush K.; Bottaro, Donald P.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4670
DI 10.1158/1538-7445.AM2014-4670
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203143
ER

PT J
AU Lee, YH
   Bottaro, DP
AF Lee, Young H.
   Bottaro, Donald P.
TI Hypoxia-mediated ROS enhances HGF-induced cancer cell invasion and
   suppresses cell cycle progression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lee, Young H.; Bottaro, Donald P.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 489
DI 10.1158/1538-7445.AM2014-489
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904453
ER

PT J
AU Li, HT
   Zhu, F
   Chen, HY
   Cheng, KW
   Zykova, T
   Oi, N
   Lubet, RA
   Bode, AM
   Wang, MF
   Dong, ZG
AF Li, Haitao
   Zhu, Feng
   Chen, Hanyong
   Cheng, Ka Wing
   Zykova, Tatyana
   Oi, Naomi
   Lubet, Ronald A.
   Bode, Ann M.
   Wang, Mingfu
   Dong, Zigang
TI 6-c-(e-phenylethenyl)-naringenin suppresses colorectal cancer growth by
   inhibiting cyclooxygenase-1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
DE colon cancer; natural product; cyclooxygenases; signal transduction
C1 [Li, Haitao; Zhu, Feng; Chen, Hanyong; Zykova, Tatyana; Oi, Naomi; Bode, Ann M.; Dong, Zigang] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA.
   [Cheng, Ka Wing; Wang, Mingfu] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
   [Lubet, Ronald A.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1252
DI 10.1158/1538-7445.AM2014-1252
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900490
ER

PT J
AU Li, HZ
   Liu, WL
   Chen, WP
   Zhu, JQ
   Deng, CX
   Rodgers, GP
AF Li, Hongzhen
   Liu, Wenli
   Chen, Weiping
   Zhu, Jianqiong
   Deng, Chu-Xia
   Rodgers, Griffin P.
TI Olfactomedin 4 inhibits prostate stem/progenitor cells growth through
   regulating the hedgehog signaling pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Li, Hongzhen; Liu, Wenli; Zhu, Jianqiong] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Chen, Weiping; Deng, Chu-Xia; Rodgers, Griffin P.] NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 604
DI 10.1158/1538-7445.AM2014-604
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905066
ER

PT J
AU Li, SR
   Hyland, PL
   Freedman, ND
   Hu, N
   Su, H
   Wang, LM
   Wang, CY
   Ding, T
   Wang, Y
   Fan, JH
   Qiao, YL
   Xiong, XQ
   Yu, K
   Goldstein, AM
   Dawsey, SM
   Taylor, PR
   Abnet, CC
   Lin, SW
AF Li, Sharon
   Hyland, Paula L.
   Freedman, Neal D.
   Hu, Nan
   Su, Hua
   Wang, Lemin
   Wang, Chaoyu
   Ding, Ti
   Wang, Yuan
   Fan, Jin-Hu
   Qiao, You-Lin
   Xiong, Xiaoqin
   Yu, Kai
   Goldstein, Alisa M.
   Dawsey, Sanford M.
   Taylor, Philip R.
   Abnet, Christian C.
   Lin, Shih-Wen
TI Genetic variants in selenoprotein genes and risk of esophageal squamous
   cell carcinoma and gastric cancer in a Chinese population
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Li, Sharon] NIH, Bethesda, MD 20892 USA.
   [Li, Sharon; Hyland, Paula L.; Freedman, Neal D.; Hu, Nan; Su, Hua; Wang, Lemin; Wang, Chaoyu; Yu, Kai; Goldstein, Alisa M.; Dawsey, Sanford M.; Taylor, Philip R.; Abnet, Christian C.; Lin, Shih-Wen] NCI, Bethesda, MD 20892 USA.
   [Ding, Ti; Wang, Yuan] Shanxi Canc Hosp & Inst, Taiyuan, Peoples R China.
   [Fan, Jin-Hu; Qiao, You-Lin] Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China.
   [Xiong, Xiaoqin] Informat Management Serv Inc, Silver Spring, MD USA.
RI Abnet, Christian/C-4111-2015; Qiao, You-Lin/B-4139-2012
OI Abnet, Christian/0000-0002-3008-7843; Qiao, You-Lin/0000-0001-6380-0871
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2206
DI 10.1158/1538-7445.AM2014-2206
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902417
ER

PT J
AU Li, WQ
   Shi, JX
   Wheeler, W
   Caporaso, N
   Laird-Offspringa, I
   Landi, MT
AF Li, Wen-Qing
   Shi, Jianxin
   Wheeler, William
   Caporaso, Neil
   Laird-Offspringa, Ite
   Landi, Maria Teresa
TI Epigenome-wide association study of normal lung tissues identifies
   hypomethylation of multiple CpG sites associated with cigarette smoking
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Li, Wen-Qing; Shi, Jianxin; Caporaso, Neil; Landi, Maria Teresa] NCI, Rockville, MD USA.
   [Wheeler, William] Informat Management Serv Inc, Rockville, MD USA.
   [Laird-Offspringa, Ite] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 286
DI 10.1158/1538-7445.AM2014-286
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904123
ER

PT J
AU Liu, JSJ
   Doody, MM
   Little, MP
   Freedman, DM
   Alexander, BH
   Kitahara, CM
   Sigurdson, AJ
   Lee, T
   Rajaraman, P
   Miller, JS
   Kampa, DM
   Simon, SL
   Preston, DL
   Linet, MS
AF Liu, Jason J.
   Doody, Michele M.
   Little, Mark P.
   Freedman, D. Michal
   Alexander, Bruce H.
   Kitahara, Cari M.
   Sigurdson, Alice J.
   Lee, Terrence
   Rajaraman, Preetha
   Miller, Jeremy S.
   Kampa, Diane M.
   Simon, Steven L.
   Preston, Dale L.
   Linet, Martha S.
TI Work history and cancer mortality risks in 90,268 United States
   radiologic technologists
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Liu, Jason J.; Doody, Michele M.; Little, Mark P.; Freedman, D. Michal; Kitahara, Cari M.; Sigurdson, Alice J.; Lee, Terrence; Rajaraman, Preetha; Simon, Steven L.; Linet, Martha S.] NCI, Rockville, MD USA.
   [Alexander, Bruce H.; Kampa, Diane M.] Univ Minnesota Sch Publ Hlth, Minneapolis, MN USA.
   [Miller, Jeremy S.] Informat Management Serv Inc, Rockville, MD USA.
   [Preston, Dale L.] Hirosoft Int, Eureka, CA USA.
RI Kitahara, Cari/R-8267-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 281
DI 10.1158/1538-7445.AM2014-281
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904068
ER

PT J
AU Liu, Z
   Christudass, C
   Zhang, H
   Chung, JY
   Hewitt, S
   Epstein, J
   Veltri, RW
AF Liu, Zhi
   Christudass, Christhunesa
   Zhang, Hui
   Chung, Joon-Yong
   Hewitt, Stephen
   Epstein, Jonathan
   Veltri, Robert W.
TI A novel quantitative histomorphological tool to assess multiple
   biomarkers to predict prostate cancer aggression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Liu, Zhi; Christudass, Christhunesa; Zhang, Hui; Epstein, Jonathan; Veltri, Robert W.] Johns Hopkins Univ Sch Med, Baltimore, MD USA.
   [Chung, Joon-Yong; Hewitt, Stephen] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4013
DI 10.1158/1538-7445.AM2014-4013
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201497
ER

PT J
AU Loftfield, E
   Mayne, S
   Shebl, F
   Freedman, N
   Graubard, B
   Sinha, R
AF Loftfield, Erikka
   Mayne, Susan
   Shebl, Fatma
   Freedman, Neal
   Graubard, Barry
   Sinha, Rashmi
TI Prospective study of coffee drinking and risk of melanoma in the United
   States
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Loftfield, Erikka; Freedman, Neal; Graubard, Barry; Sinha, Rashmi] NCI, Rockville, MD USA.
   [Mayne, Susan; Shebl, Fatma] Yale Univ, New Haven, CT USA.
RI Sinha, Rashmi/G-7446-2015
OI Sinha, Rashmi/0000-0002-2466-7462
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-280
DI 10.1158/1538-7445.AM2014-LB-280
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205312
ER

PT J
AU Long, A
   Orentas, RJ
   Mackall, CL
AF Long, Adrienne
   Orentas, Rimas J.
   Mackall, Crystal L.
TI 14g2a-based GD2-specific chimeric antigen receptors (CARs)
   constitutively signal, leading to rapidly induced T-cell exhaustion and
   poor antitumor efficacy in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Long, Adrienne] Northwestern Univ, NCI, Bethesda, MD USA.
   [Orentas, Rimas J.; Mackall, Crystal L.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2943
DI 10.1158/1538-7445.AM2014-2943
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904214
ER

PT J
AU Lu, H
   Yan, CH
   Bian, YS
   Chen, Z
   Van Waes, C
AF Lu, Hai
   Yan, Carol H.
   Bian, Yansong
   Chen, Zhong
   Van Waes, Carter
TI CK2 phosphorylates and inhibits tumor suppressor TAp73 function to
   promote cancer stem cell gene expression and phenotype in head and neck
   cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lu, Hai] Southern Med Univ, Orthopaed Ctr, Zhujiang Hosp, Guangzhou, Guangdong, Peoples R China.
   [Yan, Carol H.] Howard Hughes Med Inst NIH Res Scholars Program, Bethesda, MD 20817 USA.
   [Bian, Yansong; Chen, Zhong; Van Waes, Carter] NIDCD, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1925
DI 10.1158/1538-7445.AM2014-1925
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902140
ER

PT J
AU Lu, JM
   Risbood, P
   Kane, CT
   Hossain, MT
   Wu, YZ
   Antony, S
   Meitzler, JL
   Juhasz, A
   Liu, H
   Jiang, GJ
   Roy, K
   Doroshow, JH
AF Lu, Jiamo
   Risbood, Prabhakar
   Kane, Charles T.
   Hossain, Md Tafazzal
   Wu, Yongzhong
   Antony, Smitha
   Meitzler, Jennifer L.
   Juhasz, Agnes
   Liu, Han
   Jiang, Guojian
   Roy, Krishnendu
   Doroshow, James H.
TI Development of potent NADPH oxidase inhibitors with significant activity
   against colon cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Lu, Jiamo; Risbood, Prabhakar; Wu, Yongzhong; Antony, Smitha; Meitzler, Jennifer L.; Juhasz, Agnes; Liu, Han; Jiang, Guojian; Roy, Krishnendu; Doroshow, James H.] NCI, Bethesda, MD 20892 USA.
   [Kane, Charles T.; Hossain, Md Tafazzal] Starks Associates, Buffalo, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4750
DI 10.1158/1538-7445.AM2014-4750
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203223
ER

PT J
AU Luo, JF
   Teng, Y
   Li, MH
   Johnson, TS
   Cuttitta, F
   Chu, ZT
   Qi, XY
   Cowell, JK
   Rixe, O
AF Luo, Junfeng
   Teng, Yong
   Li, Minghui
   Johnson, Theodore S.
   Cuttitta, Franck
   Chu, Zhengtao
   Qi, Xiaoyang
   Cowell, John K.
   Rixe, Olivier
TI NOV C-ter: A novel preclinical anti-angiogenic agent
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Luo, Junfeng; Teng, Yong; Li, Minghui; Johnson, Theodore S.; Cowell, John K.; Rixe, Olivier] GRU Canc Ctr, Augusta, GA USA.
   [Luo, Junfeng; Rixe, Olivier] Georgia Regents Univ, Dept Med, Augusta, GA USA.
   [Teng, Yong; Cowell, John K.] Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA.
   [Li, Minghui; Johnson, Theodore S.] Med Coll Georgia, Dept Pediat, Augusta, GA 30912 USA.
   [Cuttitta, Franck] NCI, Angiogenesis Core Facil, Gaithersburg, MD USA.
   [Chu, Zhengtao; Qi, Xiaoyang] Univ Cincinnati, Coll Med, Cincinnati Canc Ctr, Div Hematol Oncol, Cincinnati, OH USA.
RI Cuttitta, Frank/B-4758-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1023
DI 10.1158/1538-7445.AM2014-1023
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900251
ER

PT J
AU Ma, K
   Lipkowitz, S
   Klevit, R
   Liyasova, MS
AF Ma, Ke
   Lipkowitz, Stanley
   Klevit, Rachel
   Liyasova, Mariya Sergeyevna
TI Ube2e inhibits the ubiquitination and degradation of EGFR mediated by
   Cbl and Ube2d
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Ma, Ke; Lipkowitz, Stanley; Liyasova, Mariya Sergeyevna] NCI, NIH, Bethesda, MD 20892 USA.
   [Klevit, Rachel] Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4441
DI 10.1158/1538-7445.AM2014-4441
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202414
ER

PT J
AU Ma, XT
   Loh, ML
   Rusch, M
   Edmonson, M
   Harvey, RC
   Wheeler, DA
   Hampton, OA
   Easton, J
   Yergeau, D
   Vadodaria, B
   Wu, G
   Carroll, WL
   Chen, IM
   Gerhard, DS
   Gastier-Foster, JM
   Relling, MV
   Smith, MA
   Devidas, M
   Auvil, JMG
   Downing, JR
   Willman, CL
   Mullighan, CG
   Hunger, SP
   Zhang, JH
AF Ma, Xiaotu
   Loh, Mignon L.
   Rusch, Michael
   Edmonson, Michael
   Harvey, Richard C.
   Wheeler, David A.
   Hampton, Oliver A.
   Easton, John
   Yergeau, Donald
   Vadodaria, Bhavin
   Wu, Gang
   Carroll, William L.
   Chen, I-Ming
   Gerhard, Daniela S.
   Gastier-Foster, Julie M.
   Relling, Mary V.
   Smith, Malcolm A.
   Devidas, Meenakshi
   Auvil, Jaime M. Guidry
   Downing, James R.
   Willman, Cheryl L.
   Mullighan, Charles G.
   Hunger, Stephen P.
   Zhang, Jinghui
TI Rise and fall of subclones from diagnosis to relapse in pediatric
   B-acute lymphoblastic leukemia (B-ALL): A report from the children's
   oncology group (COG) - Target - St. Jude Pediatric Cancer Genome Project
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Ma, Xiaotu; Rusch, Michael; Edmonson, Michael; Easton, John; Yergeau, Donald; Vadodaria, Bhavin; Wu, Gang; Relling, Mary V.; Downing, James R.; Mullighan, Charles G.; Zhang, Jinghui] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Loh, Mignon L.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Harvey, Richard C.; Chen, I-Ming; Willman, Cheryl L.] Univ New Mexico, Albuquerque, NM 87131 USA.
   [Wheeler, David A.; Hampton, Oliver A.] Baylor Coll Med, Human Genome Sequencing Ctr, Canc Genom, Houston, TX 77030 USA.
   [Carroll, William L.] NYU, Inst Canc, New York, NY USA.
   [Gerhard, Daniela S.; Smith, Malcolm A.; Auvil, Jaime M. Guidry] NCI, Bethesda, MD 20892 USA.
   [Gastier-Foster, Julie M.] Nationwide Childrens Hosp, Columbus, OH USA.
   [Gastier-Foster, Julie M.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
   [Devidas, Meenakshi] Univ Florida, Gainesville, FL USA.
   [Hunger, Stephen P.] Univ Colorado, Sch Med, Aurora, CO USA.
   [Hunger, Stephen P.] Childrens Hosp Colorado, Aurora, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 998
DI 10.1158/1538-7445.AM2014-998
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900224
ER

PT J
AU Maachani, UB
   Tandle, AT
   Shankavaram, U
   Meushaw, T
   Tofilon, PJ
   Camphausen, KA
AF Maachani, Uday Bhanu
   Tandle, Anita T.
   Shankavaram, Uma
   Meushaw, Tamalee
   Tofilon, Philip J.
   Camphausen, Kevin A.
TI Profiling signaling networks using reverse phase protein arrays:
   validating FOXM1 as a potential target to radiosensitize glioblastoma
   (GBM) stem cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Maachani, Uday Bhanu; Tandle, Anita T.; Shankavaram, Uma; Meushaw, Tamalee; Tofilon, Philip J.; Camphausen, Kevin A.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 849
DI 10.1158/1538-7445.AM2014-849
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905308
ER

PT J
AU Madera, D
   Vitale-Cross, L
   Martin, D
   Schneider, A
   Molinolo, A
   Gutkind, JS
AF Madera, Dmitriy
   Vitale-Cross, Lynn
   Martin, Daniel
   Schneider, Abraham
   Molinolo, Alfredo
   Gutkind, J. Silvio
TI Targeting the PI3K-mTOR signaling with metformin for the prevention of
   HPV-associated malignancies in HIV- and HIV plus individuals
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Madera, Dmitriy; Vitale-Cross, Lynn; Martin, Daniel; Molinolo, Alfredo; Gutkind, J. Silvio] Natl Inst Dent Craniofacial Res, NIH, Bethesda, MD USA.
   [Schneider, Abraham] Univ Maryland, Baltimore, MD 21201 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-243
DI 10.1158/1538-7445.AM2014-LB-243
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205274
ER

PT J
AU Madka, V
   Mohammed, A
   Li, Q
   Zhang, YT
   Biddick, L
   Lightfoot, S
   Wu, XR
   Kopelovich, L
   Steele, V
   Rao, CV
AF Madka, Venkateshwar
   Mohammed, Altaf
   Li, Qian
   Zhang, Yuting
   Biddick, Laura
   Lightfoot, Stanley
   Wu, Xue-Re
   Kopelovich, Levy
   Steele, Vernon
   Rao, Chinthallapally V.
TI Licofelone, a dual COX-LOX inhibitor prevents transitional cell
   carcinoma of urinary bladder in UPII-SV40T transgenic mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Madka, Venkateshwar; Mohammed, Altaf; Li, Qian; Zhang, Yuting; Biddick, Laura; Lightfoot, Stanley; Rao, Chinthallapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Wu, Xue-Re] NY Med Ctr, New York, NY USA.
   [Kopelovich, Levy; Steele, Vernon] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1244
DI 10.1158/1538-7445.AM2014-1244
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900482
ER

PT J
AU Manning, ML
   Mason-Osann, E
   Onda, M
   Pastan, I
AF Manning, Michael L.
   Mason-Osann, Emily
   Onda, Masanori
   Pastan, Ira
TI Bortezomib reduces preexisting antibodies to recombinant immunotoxins in
   mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Manning, Michael L.; Mason-Osann, Emily; Onda, Masanori; Pastan, Ira] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2586
DI 10.1158/1538-7445.AM2014-2586
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903328
ER

PT J
AU Mattoo, AR
   Zhang, JY
   Espinoza, LA
   Thorgeirsson, SS
   Jessup, JM
AF Mattoo, Abid R.
   Zhang, Jingyu
   Espinoza, Luis A.
   Thorgeirsson, Snorri S.
   Jessup, J. M.
TI Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer
   (CRC) cells, enhances the efficacy of BH3 mimetics and inhibits
   clonogenicity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mattoo, Abid R.; Zhang, Jingyu; Espinoza, Luis A.; Thorgeirsson, Snorri S.] NCI, Bethesda, MD 20892 USA.
   [Jessup, J. M.] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 339
DI 10.1158/1538-7445.AM2014-339
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904307
ER

PT J
AU Maxwell, KN
   Guidugli, L
   Schrader, K
   Hart, S
   Joseph, V
   Thomas, T
   Wang, XS
   Wubbenhorst, B
   Klein, R
   Domchek, SM
   Szabo, C
   Neuhausen, S
   Weitzel, J
   Nathanson, KL
   Offit, K
   Couch, F
AF Maxwell, Kara N.
   Guidugli, Lucia
   Schrader, Kasmintan
   Hart, Steven
   Joseph, Vijai
   Thomas, Tinu
   Wang, Xianshu
   Wubbenhorst, Bradley
   Klein, Robert
   Domchek, Susan M.
   Szabo, Csilla
   Neuhausen, Susan
   Weitzel, Jeffrey
   Nathanson, Katherine L.
   Offit, Kenneth
   Couch, Fergus
TI High and moderate penetrance germline mutations in a number of genes are
   responsible for a small proportion of familial breast cancer risk in
   BRCAx families
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Maxwell, Kara N.; Wubbenhorst, Bradley; Domchek, Susan M.; Nathanson, Katherine L.] Univ Penn, Philadelphia, PA 19104 USA.
   [Guidugli, Lucia; Hart, Steven; Wang, Xianshu; Couch, Fergus] Mayo Clin, Rochester, MN USA.
   [Schrader, Kasmintan; Joseph, Vijai; Thomas, Tinu; Klein, Robert; Offit, Kenneth] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Szabo, Csilla] NIH, Bethesda, MD 20892 USA.
   [Neuhausen, Susan; Weitzel, Jeffrey] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1291
DI 10.1158/1538-7445.AM2014-1291
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901026
ER

PT J
AU McMaster, ML
   Goldin, LR
   Rotunno, M
   He, J
   Burdette, L
   Hutchinson, A
   Boland, J
   Yeager, M
   Tucker, MA
   Chanock, SJ
   Caporaso, NE
AF McMaster, Mary L.
   Goldin, Lynn R.
   Rotunno, Melissa
   He, Ji
   Burdette, Laurie
   Hutchinson, Amy
   Boland, Joseph
   Yeager, Meredith
   Tucker, Margaret A.
   Chanock, Stephen J.
   Caporaso, Neil E.
TI Exploration of rare variants from exome sequencing in families with
   Waldenstrom macroglobulinemia (WM)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [McMaster, Mary L.; Goldin, Lynn R.; Rotunno, Melissa; He, Ji; Burdette, Laurie; Hutchinson, Amy; Boland, Joseph; Yeager, Meredith; Tucker, Margaret A.; Chanock, Stephen J.; Caporaso, Neil E.] NCI, DCEG, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1300
DI 10.1158/1538-7445.AM2014-1300
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901035
ER

PT J
AU Meskini, RE
   Iacovelli, A
   Kulaga, A
   Gumprecht, M
   Martin, P
   Baran, M
   Householder, D
   Van Dyke, T
   Ohler, ZW
AF Meskini, Rajaa E.
   Iacovelli, Anthony
   Kulaga, Alan
   Gumprecht, Michelle
   Martin, Philip
   Baran, Maureen
   Householder, Deborah
   Van Dyke, Terry
   Ohler, Zoe Weaver
TI Combined inhibition of MEK and PI3 kinase signaling results in improved
   survival in a preclinical orthotopic model for human glioblastoma
   multiforme
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Meskini, Rajaa E.; Iacovelli, Anthony; Kulaga, Alan; Gumprecht, Michelle; Martin, Philip; Baran, Maureen; Ohler, Zoe Weaver] Leidos Biomed Res NCI Frederick, Frederick, MD USA.
   [Householder, Deborah; Van Dyke, Terry] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3137
DI 10.1158/1538-7445.AM2014-3137
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200142
ER

PT J
AU Mishra, P
AF Mishra, Prachi
TI Aberrant accumulation of 2-hydroxyglutarate in human breast cancer with
   myc activation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mishra, Prachi] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2952
DI 10.1158/1538-7445.AM2014-2952
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904224
ER

PT J
AU Mishra, PJ
   Guo, T
   Zaidi, R
   Davis, S
   Michalowski, A
   Michael, H
   Reinhold, W
   Arnheiter, H
   Meltzer, P
   Merlino, G
AF Mishra, Pravin J.
   Guo, Theresa
   Zaidi, Raza
   Davis, Sean
   Michalowski, Aleksandra
   Michael, Helen
   Reinhold, William
   Arnheiter, Heinz
   Meltzer, Paul
   Merlino, Glenn
TI Integrated embryonic transcriptome analyses identify key melanoma
   metastasis regulator
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mishra, Pravin J.; Guo, Theresa; Zaidi, Raza; Michalowski, Aleksandra; Michael, Helen; Merlino, Glenn] NCI, Lab Canc Biol & Genet, NIH, Bethesda, MD 20892 USA.
   [Davis, Sean; Meltzer, Paul] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Reinhold, William] NCI, Lab Mol Pharmacol, NIH, Bethesda, MD 20892 USA.
   [Arnheiter, Heinz] NINDS, NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 994
DI 10.1158/1538-7445.AM2014-994
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905462
ER

PT J
AU Mitra, D
   Li, B
   Zhang, QH
   Mitchell, JB
   Wang, XJ
AF Mitra, Doyel
   Li, Bian
   Zhang, Qinghong
   Mitchell, James B.
   Wang, Xiao-Jing
TI Tempol diet provides chemoprotection against UV-induced skin cancer in
   mice with epidermal Smad4 deletion
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mitra, Doyel; Zhang, Qinghong; Wang, Xiao-Jing] Univ Colorado Denver, Aurora, CO USA.
   [Li, Bian] Kunming Univ, Affiliated Hosp 1, Kunming, Peoples R China.
   [Mitchell, James B.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2258
DI 10.1158/1538-7445.AM2014-2258
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902472
ER

PT J
AU Miyajima, N
   Akino, T
   Tsuchiya, K
   Maruyama, S
   Abe, T
   Shinohara, N
   Nonomura, K
   Neckers, L
AF Miyajima, Naoto
   Akino, Tomoshige
   Tsuchiya, Kunihiko
   Maruyama, Satoru
   Abe, Takashige
   Shinohara, Nobuo
   Nonomura, Katsuya
   Neckers, Len
TI The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor
   crizotinib in both crizotinib-sensitive and crizotinib-resistant
   MET-driven renal tumor models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Miyajima, Naoto; Akino, Tomoshige; Tsuchiya, Kunihiko; Maruyama, Satoru; Abe, Takashige; Shinohara, Nobuo; Nonomura, Katsuya] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan.
   [Neckers, Len] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3722
DI 10.1158/1538-7445.AM2014-3722
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201213
ER

PT J
AU Mizutani, A
   Matsuda, S
   Yan, T
   Prieto-Vila, M
   Chen, L
   Satoh, A
   Kasai, T
   Masuda, J
   Kudoh, T
   Murakami, H
   Fu, L
   Salomon, DS
   Seno, M
AF Mizutani, Akifumi
   Matsuda, Shuichi
   Yan, Ting
   Prieto-Vila, Marta
   Chen, Ling
   Satoh, Ayano
   Kasai, Tomonari
   Masuda, Junko
   Kudoh, Takyuki
   Murakami, Hiroshi
   Fu, Li
   Salomon, David S.
   Seno, Masaharu
TI Cancer stem cells maintain a hierarchy of differentiation by creating
   their niche
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mizutani, Akifumi; Matsuda, Shuichi; Yan, Ting; Prieto-Vila, Marta; Satoh, Ayano; Kasai, Tomonari; Masuda, Junko; Kudoh, Takyuki; Murakami, Hiroshi; Seno, Masaharu] Okayama Univ, Okayama 7008530, Japan.
   [Chen, Ling; Fu, Li] Tianjin Cent Hosp Gynecol Obstet, Tianjin, Peoples R China.
   [Salomon, David S.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3026
DI 10.1158/1538-7445.AM2014-3026
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200033
ER

PT J
AU Mohammed, A
   Janakiram, NB
   Ritchie, RL
   Biddick, L
   Brewer, M
   Lightfoot, S
   Steele, VE
   Rao, CV
AF Mohammed, Altaf
   Janakiram, Naveena B.
   Ritchie, Rebekah L.
   Biddick, Laura
   Brewer, Misty
   Lightfoot, Stan
   Steele, Vernon E.
   Rao, Chinthalapally V.
TI Combinational Targeting of EGFR and ODC pathways by Gefitinib and DFMO
   lead to complete blockade of PanIN progression to pancreatic ductal
   adenocarcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mohammed, Altaf; Janakiram, Naveena B.; Ritchie, Rebekah L.; Biddick, Laura; Brewer, Misty; Lightfoot, Stan; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2969
DI 10.1158/1538-7445.AM2014-2969
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904241
ER

PT J
AU Mohan, S
   Broek, RJV
   Saleh, AD
   Pierce, ML
   Coupar, JF
   Eytan, DF
   Chen, Z
   Van Waes, C
AF Mohan, Suresh
   Broek, Robert J. Vander
   Saleh, Anthony D.
   Pierce, Matthew L.
   Coupar, Jamie F.
   Eytan, Danielle F.
   Chen, Zhong
   Van Waes, Carter
TI PI3K/mTOR dual inhibitor PF-5212384 inhibits aberrant NF-kB activation
   and exhibits activity in combination with MEK inhibitor PD-325901 and
   docetaxel in human head and neck squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mohan, Suresh; Broek, Robert J. Vander; Saleh, Anthony D.; Pierce, Matthew L.; Coupar, Jamie F.; Eytan, Danielle F.; Chen, Zhong; Van Waes, Carter] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2623
DI 10.1158/1538-7445.AM2014-2623
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903369
ER

PT J
AU Moiola, CP
   Luca, PD
   Zalazar, F
   Segui, SR
   Cotignola, J
   Meiss, R
   Vazquez, E
   Dalton, N
   Labanca, E
   Gardner, K
   Siervi, AD
AF Moiola, Cristian P.
   Luca, Paola D.
   Zalazar, Florencia
   Rodriguez Segui, Santiago
   Cotignola, Javier
   Meiss, Roberto
   Vazquez, Elba
   Dalton, Nicolas
   Labanca, Estefania
   Gardner, Kevin
   Siervi, Adriana D.
TI CtBP1 is implicated in prostate tumor development in a metabolic
   syndrome-like disease in vivo model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Moiola, Cristian P.; Luca, Paola D.; Zalazar, Florencia; Dalton, Nicolas; Labanca, Estefania; Siervi, Adriana D.] Consejo Nacl Invest Cient & Tecn, Inst Biol & Expt Med IByME, RA-1033 Buenos Aires, DF, Argentina.
   [Rodriguez Segui, Santiago; Cotignola, Javier; Vazquez, Elba] Univ Buenos Aires, IQUIBICEN, Buenos Aires, DF, Argentina.
   [Meiss, Roberto] Univ Buenos Aires, Fac Med, Natl Acad Med, Buenos Aires, DF, Argentina.
   [Gardner, Kevin] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 247
DI 10.1158/1538-7445.AM2014-247
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903201
ER

PT J
AU Mondul, AM
   Moore, S
   Weinstein, S
   Mannisto, S
   Sampson, J
   Albanes, D
AF Mondul, Alison M.
   Moore, Steven
   Weinstein, Stephanie
   Mannisto, Satu
   Sampson, Johsua
   Albanes, Demetrius
TI 1-stearoylglycerol is associated with risk of prostate cancer: Results
   from serum metabolomic profiling
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Mondul, Alison M.; Moore, Steven; Weinstein, Stephanie; Sampson, Johsua; Albanes, Demetrius] NCI DCEG, Rockville, MD USA.
   [Mannisto, Satu] Natl Inst Hlth & Welf, Helsinki, Finland.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5068
DI 10.1158/1538-7445.AM2014-5068
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204023
ER

PT J
AU Moody, TW
   Lee, SH
   Perez, PM
   Jensen, RT
AF Moody, Terry W.
   Lee, Suk Hee
   Perez, Paola Moreno
   Jensen, Robert T.
TI G-protein coupled receptors for cholecystokinin regulate transactivation
   of EGF receptors in lung cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Moody, Terry W.] NCI CCR, Bethesda, MD USA.
   [Lee, Suk Hee; Perez, Paola Moreno; Jensen, Robert T.] NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2125
DI 10.1158/1538-7445.AM2014-2125
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902338
ER

PT J
AU Moon, BH
   Suman, S
   Li, HH
   Yang, Q
   Strawn, SJ
   LoBello, J
   Mazur, SJ
   Appella, E
   Chen, S
   Fornace, AJ
AF Moon, Bo-Hyun
   Suman, Shubhankar
   Li, Henghong
   Yang, Qian
   Strawn, Steven J.
   LoBello, Janine
   Mazur, Sharlyn J.
   Appella, Ettore
   Chen, Suzie
   Fornace, Albert J.
TI Deficient expression of oncogenic Wip1 (PPM1D) negatively regulates
   melanoma progression and metastasis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Moon, Bo-Hyun; Fornace, Albert J.] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA.
   [Suman, Shubhankar; Li, Henghong; Yang, Qian; Strawn, Steven J.] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA.
   [LoBello, Janine] Translat Genom Res Inst, Phoenix, AZ USA.
   [Mazur, Sharlyn J.; Appella, Ettore] NCI, Chem Immunol Sect, Cell Biol Lab, Bethesda, MD 20892 USA.
   [Chen, Suzie] Rutgers State Univ, Susan Lehman Cullen Lab Canc Res, Dept Biol Chem, Ernest Mario Sch Pharm, New Brunswick, NJ 08903 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1998
DI 10.1158/1538-7445.AM2014-1998
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902212
ER

PT J
AU Morris, J
   Kunkel, M
   Polley, E
   Holbeck, S
   Monks, A
   Evans, D
   Rapisarda, A
   Collins, J
   Teicher, B
AF Morris, Joel
   Kunkel, Mark
   Polley, Eric
   Holbeck, Susan
   Monks, Anne
   Evans, David
   Rapisarda, Annamaria
   Collins, Jerry
   Teicher, Beverly
TI Interrogation of NCI-60 patterns of growth inhibition in conjunction
   with investigational oncology agents kinase profiling for the
   elucidation of mechanistic targets
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Morris, Joel; Kunkel, Mark; Polley, Eric; Holbeck, Susan; Collins, Jerry; Teicher, Beverly] NCI, Rockville, MD USA.
   [Monks, Anne; Evans, David; Rapisarda, Annamaria] NCI, Frederick, MD 21701 USA.
NR 0
TC 1
Z9 1
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5475
DI 10.1158/1538-7445.AM2014-5475
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204393
ER

PT J
AU Morrison, BL
   Whiting, AL
   Bernal, F
AF Morrison, Bethanie L.
   Whiting, Amanda L.
   Bernal, Federico
TI SAH-p53-mediated inhibition of cell migration via alteration of actin
   dynamics
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Morrison, Bethanie L.; Whiting, Amanda L.; Bernal, Federico] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4071
DI 10.1158/1538-7445.AM2014-4071
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202054
ER

PT J
AU Moy, KA
   Weinstein, S
   Mannisto, S
   Albanes, D
AF Moy, Kristin A.
   Weinstein, Stephanie
   Mannisto, Satu
   Albanes, Demetrius
TI 2183: Serum alpha-tocopherol, beta carotene and cancer survival in the
   ATBC Study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Moy, Kristin A.; Weinstein, Stephanie; Albanes, Demetrius] NCI, Rockville, MD USA.
   [Mannisto, Satu] Natl Inst Hlth & Welf, Helsinki, Finland.
NR 0
TC 1
Z9 1
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2183
DI 10.1158/1538-7445.AM2014-2183
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902394
ER

PT J
AU Murai, J
   Josse, R
   Doroshow, JH
   Pommier, Y
AF Murai, Junko
   Josse, Rozenn
   Doroshow, James H.
   Pommier, Yves
TI Schlafen 11 (SLFN11) is a critical determinant of cellular sensitivity
   to PARP inhibitors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Murai, Junko] Kyoto Univ, Kyoto, Japan.
   [Josse, Rozenn; Doroshow, James H.; Pommier, Yves] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1718
DI 10.1158/1538-7445.AM2014-1718
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901440
ER

PT J
AU Murgai, M
   Giles, A
   Kasai, M
   Vicioso, Y
   Mackall, C
   Kaplan, R
AF Murgai, Meera
   Giles, Amber
   Kasai, Miki
   Vicioso, Yorleny
   Mackall, Crystal
   Kaplan, Rosandra
TI Metastasis prevention using fibroblast activation protein-targeting
   prodrugs at the pre-metastatic niche
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Murgai, Meera; Giles, Amber; Kasai, Miki; Vicioso, Yorleny; Mackall, Crystal; Kaplan, Rosandra] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2074
DI 10.1158/1538-7445.AM2014-2074
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902287
ER

PT J
AU Murthy, SRK
   Lee, TK
   Cawley, NX
   Hewitt, SM
   Loh, PY
AF Murthy, Saravana R. K.
   Lee, Terence K.
   Cawley, Niamh X.
   Hewitt, Stephen M.
   Loh, Peng Y.
TI CPE-delta-N promotes metastasis by regulating Nedd9 and Yap1 expression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Murthy, Saravana R. K.; Cawley, Niamh X.; Loh, Peng Y.] NIH NI CHD, Bethesda, MD USA.
   [Lee, Terence K.] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
   [Hewitt, Stephen M.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2003
DI 10.1158/1538-7445.AM2014-2003
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902216
ER

PT J
AU Muscarella, LA
   La Torre, A
   Sparaneo, A
   Palumbo, O
   Storlazzi, CT
   Balsamo, T
   Trombetta, D
   Pellegrini, F
   Barbano, R
   Pasculli, B
   Graziano, P
   Sanchez-Cespedes, M
   Landi, MT
   Parrella, P
   Fazio, VM
AF Muscarella, Lucia Anna
   La Torre, Annamaria
   Sparaneo, Angelo
   Palumbo, Orazio
   Storlazzi, Clelia Tiziana
   Balsamo, Teresa
   Trombetta, Domenico
   Pellegrini, Fabio
   Barbano, Raffaela
   Pasculli, Barbara
   Graziano, Paolo
   Sanchez-Cespedes, Montse
   Landi, Maria Teresa
   Parrella, Paola
   Fazio, Vito Michele
TI nrf2-keap1 axis molecular profile in small cell lung cancer cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Muscarella, Lucia Anna; La Torre, Annamaria; Sparaneo, Angelo; Palumbo, Orazio; Balsamo, Teresa; Trombetta, Domenico; Pellegrini, Fabio; Barbano, Raffaela; Pasculli, Barbara; Graziano, Paolo; Parrella, Paola; Fazio, Vito Michele] IRCCS Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.
   [Storlazzi, Clelia Tiziana] Univ Bari, Dept Biol, Bari, Italy.
   [Sanchez-Cespedes, Montse] Bellvitge Biomed Res Insititute IDIBELL, Barcelona, Spain.
   [Landi, Maria Teresa] NCI, NIH, Bethesda, MD 20892 USA.
RI Barbano, Raffaela/H-3640-2016; Trombetta, Domenico/K-6344-2016;
   Sparaneo, Angelo/B-4689-2017; PALUMBO, ORAZIO/C-1133-2014
OI Barbano, Raffaela/0000-0002-4533-4157; Trombetta,
   Domenico/0000-0002-6156-8500; PALUMBO, ORAZIO/0000-0001-6583-3482
NR 0
TC 0
Z9 0
U1 2
U2 5
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2251
DI 10.1158/1538-7445.AM2014-2251
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902465
ER

PT J
AU Myung, K
AF Myung, Kyungjae
TI Identification of a small molecule selectively kill mismatch repair
   deficient tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Myung, Kyungjae] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2732
DI 10.1158/1538-7445.AM2014-2732
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903485
ER

PT J
AU Navas, T
   Lawrence, SL
   Butcher, D
   Dutko, LM
   Hollingshead, MG
   Kinders, RJ
   Parchment, RE
   Bottaro, DP
   Linehan, WM
   Tomaszewski, JE
   Srivastava, AK
   Doroshow, JH
AF Navas, Tony
   Lawrence, Scott L.
   Butcher, Donna
   Dutko, Lindsay M.
   Hollingshead, Melinda G.
   Kinders, Robert J.
   Parchment, Ralph E.
   Bottaro, Donald P.
   Linehan, W. Marston
   Tomaszewski, Joseph E.
   Srivastava, Apurva K.
   Doroshow, James H.
TI Quantitative immunofluorescence assessment of MET and epithelial to
   mesenchymal transition (EMT) biomarker modulation by antiangiogenic
   inhibitors in xenograft tumor tissues
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Navas, Tony; Lawrence, Scott L.; Kinders, Robert J.; Parchment, Ralph E.; Srivastava, Apurva K.] Leidos Biomed Res Inc, Lab Human Toxicol & Pharmacol, Appl Dev Directorate, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Butcher, Donna; Dutko, Lindsay M.] Leidos Biomed Res Inc, Pathol Histotechnol Lab, Lab Anim Sci Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Hollingshead, Melinda G.] NCI, Biol Testing Branch, Dev Therapeut Program, Frederick, MD 21701 USA.
   [Bottaro, Donald P.; Linehan, W. Marston] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Tomaszewski, Joseph E.] Div Canc Treatment & Diag, Bethesda, MD USA.
   [Tomaszewski, Joseph E.] Ctr Canc Res, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1049
DI 10.1158/1538-7445.AM2014-1049
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900279
ER

PT J
AU Nguyen, D
   Rubinstein, L
   Sherman, ME
   Tomaszewski, JE
   Takebe, N
   Ivy, P
   Doroshow, JH
   Yang, SX
AF Nguyen, Dat
   Rubinstein, Larry
   Sherman, Mark E.
   Tomaszewski, Joseph E.
   Takebe, Naoko
   Ivy, Percy
   Doroshow, James H.
   Yang, Sherry X.
TI Differential expression of Notch1 in lung, ovarian and breast cancers
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Nguyen, Dat; Rubinstein, Larry; Tomaszewski, Joseph E.; Takebe, Naoko; Ivy, Percy; Doroshow, James H.; Yang, Sherry X.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Sherman, Mark E.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3838
DI 10.1158/1538-7445.AM2014-3838
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201327
ER

PT J
AU Nickerson, ML
   Das, S
   Lou, H
   Li, HC
   Turan, S
   Im, K
   Anderson, S
   Andresson, T
   Dean, M
AF Nickerson, Michael L.
   Das, Sudipto
   Lou, Hong
   Li, Hongchuan
   Turan, Sevilay
   Im, Kate
   Anderson, Stephen
   Andresson, Thorkell
   Dean, Michael
TI TET2 alterations facilitate progression of metastatic prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Nickerson, Michael L.; Das, Sudipto; Lou, Hong; Li, Hongchuan; Turan, Sevilay; Im, Kate; Anderson, Stephen; Andresson, Thorkell; Dean, Michael] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 454
DI 10.1158/1538-7445.AM2014-454
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904418
ER

PT J
AU Niederfellner, G
   Bauss, F
   Imhof-Jung, S
   Hesse, F
   Kronenberg, S
   Staak, R
   Lechmann, M
   Krippendorff, B
   Richter, W
   Mateus, R
   Kollmorgen, G
   Brinkmann, U
   Onda, M
   Pastan, I
   Bosslet, K
AF Niederfellner, Gerhard
   Bauss, Frieder
   Imhof-Jung, Sabine
   Hesse, Friederike
   Kronenberg, Sven
   Staak, Roland
   Lechmann, Martin
   Krippendorff, Ben
   Richter, Wolfgang
   Mateus, Rita
   Kollmorgen, Gwendlyn
   Brinkmann, Ulli
   Onda, Masanori
   Pastan, Ira
   Bosslet, Klaus
TI RG7787-a novel de-immunized PE based fusion protein for therapy of
   mesothelin-positive solid tumors
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Niederfellner, Gerhard; Bauss, Frieder; Imhof-Jung, Sabine; Hesse, Friederike; Staak, Roland; Lechmann, Martin; Krippendorff, Ben; Richter, Wolfgang; Mateus, Rita; Kollmorgen, Gwendlyn; Brinkmann, Ulli; Bosslet, Klaus] Roche Diagnost GmbH, Penzberg, Germany.
   [Kronenberg, Sven] F Hoffmann La Roche & Cie AG, Basel, Switzerland.
   [Onda, Masanori; Pastan, Ira] NIH, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4510
DI 10.1158/1538-7445.AM2014-4510
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202482
ER

PT J
AU Niemann, CU
   Montraveta, A
   Herman, SEM
   Ingallinera, T
   Barf, T
   Colomer, D
   Wiestner, A
AF Niemann, Carsten U.
   Montraveta, Arnau
   Herman, Sarah E. M.
   Ingallinera, Tim
   Barf, Tjeerd
   Colomer, Dolors
   Wiestner, Adrian
TI The novel Bruton's tyrosine kinase inhibitor ACP-196 shows in vivo
   efficacy against human chronic lymphocytic leukemia cells xenografted to
   the NSG mouse model
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Niemann, Carsten U.; Herman, Sarah E. M.; Wiestner, Adrian] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Montraveta, Arnau; Colomer, Dolors] IDIBAPS, Barcelona, Spain.
   [Ingallinera, Tim] Acerta Pharma, San Carlos, CA USA.
   [Barf, Tjeerd] Acerta Pharma, Oss, Netherlands.
RI Niemann, Carsten/P-3497-2015
OI Niemann, Carsten/0000-0001-9880-5242
NR 0
TC 2
Z9 2
U1 0
U2 6
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2624
DI 10.1158/1538-7445.AM2014-2624
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903370
ER

PT J
AU Nogales, V
   Moutinho, C
   Martinez-Cardus, A
   Varma, S
   Killian, JK
   Reinhold, WC
   Meltzer, PS
   Pommier, Y
   Esteller, M
AF Nogales, Vanesa
   Moutinho, Catia
   Martinez-Cardus, Anna
   Varma, Sudhir
   Killian, J. Keith
   Reinhold, William C.
   Meltzer, Paul S.
   Pommier, Yves
   Esteller, Manel
TI Discovery of biomarkers for antitumor drug resistance using 450K
   methylation data of NCI60
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Nogales, Vanesa; Moutinho, Catia; Martinez-Cardus, Anna; Esteller, Manel] Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain.
   [Varma, Sudhir; Killian, J. Keith; Reinhold, William C.; Meltzer, Paul S.; Pommier, Yves] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1366
DI 10.1158/1538-7445.AM2014-1366
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901098
ER

PT J
AU Nogueira, LM
   Stolzenberg-Solomon, R
   Gamborg, M
   Sorensen, T
   Baker, J
AF Nogueira, Leticia M.
   Stolzenberg-Solomon, Rachael
   Gamborg, Michael
   Sorensen, Thorkild
   Baker, Jennifer
TI Childhood BMI is associated with risk of adult pancreatic cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Nogueira, Leticia M.; Stolzenberg-Solomon, Rachael] NCI, Rockville, MD USA.
   [Gamborg, Michael; Sorensen, Thorkild; Baker, Jennifer] Inst Prevent Med, Copenhagen, Denmark.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2916
DI 10.1158/1538-7445.AM2014-2916
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904184
ER

PT J
AU O'Hayre, ML
   Kufareva, I
   Vaque, JP
   Piris, MA
   Gutkind, JS
AF O'Hayre, Morgan L.
   Kufareva, Irina
   Vaque, Jose P.
   Piris, Miguel A.
   Gutkind, J. Silvio
TI Deciphering the effects of GNA13 mutations in B-cell lymphomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [O'Hayre, Morgan L.; Gutkind, J. Silvio] NIH, Bethesda, MD 20892 USA.
   [Kufareva, Irina] UCSD, La Jolla, CA USA.
   [Vaque, Jose P.; Piris, Miguel A.] IFIMAV, Santander, Spain.
RI Piris, Miguel/B-7067-2008
OI Piris, Miguel/0000-0001-5839-3634
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4202
DI 10.1158/1538-7445.AM2014-4202
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202179
ER

PT J
AU Panagiotou, OA
   Gu, FY
   Reyes-Guzman, C
   Landi, MT
   Bloch, M
   Caporaso, NE
   Wacholder, S
AF Panagiotou, Orestis A.
   Gu, Fangyi
   Reyes-Guzman, Carolyn
   Landi, Maria-Teresa
   Bloch, Michele
   Caporaso, Neil E.
   Wacholder, Sholom
TI Causal effects of delaying smoking initiation on subsequent lung cancer
   risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Panagiotou, Orestis A.; Gu, Fangyi; Reyes-Guzman, Carolyn; Landi, Maria-Teresa; Bloch, Michele; Caporaso, Neil E.; Wacholder, Sholom] NCI, Bethesda, MD 20892 USA.
RI Panagiotou, Orestis/I-5934-2015
OI Panagiotou, Orestis/0000-0001-9604-8380
NR 0
TC 1
Z9 1
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2157
DI 10.1158/1538-7445.AM2014-2157
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902369
ER

PT J
AU Parpart, ST
   Roessler, S
   Dong, F
   Rao, V
   Ji, JF
   Qin, LX
   Ye, QH
   Tang, ZY
   Jia, HL
   Wang, XW
AF Parpart, Sonya T.
   Roessler, Stephanie
   Dong, Fei
   Rao, Vinay
   Ji, Junfang
   Qin, Lun-Xiu
   Ye, Qing-Hai
   Tang, Zhao-You
   Jia, Hu-Liang
   Wang, Xin Wei
TI Modulation of miR-29 expression by alpha-fetoprotein is linked to the
   hepatocellular carcinoma epigenome
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Parpart, Sonya T.; Wang, Xin Wei] NIH, Bethesda, MD USA.
   [Roessler, Stephanie] Heidelberg Univ, Inst Pathol, Heidelberg, Germany.
   [Dong, Fei] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.
   [Rao, Vinay] UConn Hlth Ctr, Dept Internal Med, Farmington, CT USA.
   [Ji, Junfang] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
   [Qin, Lun-Xiu; Ye, Qing-Hai; Tang, Zhao-You; Jia, Hu-Liang] Fudan Univ, Liver Canc Inst, Shanghai 200032, Peoples R China.
   [Qin, Lun-Xiu; Ye, Qing-Hai; Tang, Zhao-You; Jia, Hu-Liang] Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5183
DI 10.1158/1538-7445.AM2014-5183
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204134
ER

PT J
AU Pasqualini, L
   Bu, HJ
   Narisu, N
   Rainer, J
   Schweiger, MR
   Chines, PS
   Fuchsberger, C
   Klocker, H
AF Pasqualini, Lorenza
   Bu, Huajie
   Narisu, Narisu
   Rainer, Johannes
   Schweiger, Michal R.
   Chines, Peter S.
   Fuchsberger, Christian
   Klocker, Helmut
TI miRNAs and androgen receptor interplay in prostate cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Pasqualini, Lorenza; Bu, Huajie; Klocker, Helmut] Med Univ Innsbruck, Dept Urol, A-6020 Innsbruck, Austria.
   [Narisu, Narisu; Chines, Peter S.] NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA.
   [Rainer, Johannes] Med Univ Innsbruck, Bioctr Innsbruck, Sect Mol Pathophysiol, A-6020 Innsbruck, Austria.
   [Schweiger, Michal R.] Max Planck Inst Mol Genet, D-14195 Berlin, Germany.
   [Fuchsberger, Christian] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
RI Schweiger, Michal/H-5270-2015
OI Schweiger, Michal/0000-0002-4672-0623
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3549
DI 10.1158/1538-7445.AM2014-3549
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201045
ER

PT J
AU Pastan, I
   Hollevoet, K
   Mason-Osann, E
   Alewine, C
   Liu, XF
AF Pastan, Ira
   Hollevoet, Kevin
   Mason-Osann, Emily
   Alewine, Christine
   Liu, Xiu-Fen
TI Anti-tumor activity in pancreatic cancer of a low immunogenic and
   clinically optimized anti-mesothelin immunotoxin RG7787
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Pastan, Ira; Mason-Osann, Emily; Alewine, Christine; Liu, Xiu-Fen] NCI, Bethesda, MD 20892 USA.
   [Hollevoet, Kevin] Dept Pharmaceut & Pharmacol Sci, Lab Therapeut & Diagnost Antibodies, Leuven, Belgium.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4505
DI 10.1158/1538-7445.AM2014-4505
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202477
ER

PT J
AU Patlolla, JMR
   Kopelovich, L
   Qian, L
   Biddick, L
   Zhang, YT
   Sadeghi, MK
   Desai, D
   Amin, S
   Lightfoot, S
   Steele, VE
   Rao, CV
AF Patlolla, Jagan Mohan Reddy
   Kopelovich, Levy
   Qian, Li
   Biddick, Laura
   Zhang, Yuting
   Sadeghi, Michael K.
   Desai, Dhimant
   Amin, Shantu
   Lightfoot, Stan
   Steele, Vernon E.
   Rao, Chinthalapally V.
TI Chemoprevention of tobacco carcinogen-induced lung cancer by DFMO and
   Licofelone administered individually or in combination in female A/J
   mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Patlolla, Jagan Mohan Reddy; Qian, Li; Biddick, Laura; Zhang, Yuting; Sadeghi, Michael K.; Lightfoot, Stan; Rao, Chinthalapally V.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Kopelovich, Levy; Steele, Vernon E.] NCI, Bethesda, MD 20892 USA.
   [Desai, Dhimant; Amin, Shantu] Hershey Med Ctr, Hershey, PA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2135
DI 10.1158/1538-7445.AM2014-2135
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902347
ER

PT J
AU Paul, RK
   Wnorowski, A
   Bernier, M
   Wainer, IW
AF Paul, Rajib K.
   Wnorowski, Artur
   Bernier, Michel
   Wainer, Irving W.
TI Inhibition of cell proliferation by (R,R ')-4
   '-methoxy-1-naphthylfenoterol in breast cancer cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Paul, Rajib K.; Wnorowski, Artur; Bernier, Michel; Wainer, Irving W.] NIA, NIH, Baltimore, MD 21224 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4535
DI 10.1158/1538-7445.AM2014-4535
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203009
ER

PT J
AU Peng, HZ
   Farrooji, MTZ
   Osborne, MJ
   Prokop, JW
   McDonald, PC
   Karar, J
   Hou, ZY
   He, M
   Kebebew, E
   Orntoft, T
   Herlyn, M
   Caton, AJ
   Fredericks, W
   Malkowicz, B
   Paterno, CS
   Carolin, AS
   Speicher, DW
   Skordalakes, E
   Huang, QH
   Dedhar, SS
   Borden, KLB
   Rauscher, FJ
AF Peng, Hongzhuang
   Farrooji, Mehdi Taleb Zadeh
   Osborne, Michael J.
   Prokop, Jeremy W.
   McDonald, Paul C.
   Karar, Jayashree
   Hou, Zhaoyuan
   He, Mei
   Kebebew, Electron
   Orntoft, Torben
   Herlyn, Meenhard
   Caton, Andrew J.
   Fredericks, William
   Malkowicz, Bruce
   Paterno, Christopher S.
   Carolin, Alexandra S.
   Speicher, David W.
   Skordalakes, Emmanuel
   Huang, Qihong
   Dedhar, Shoukat S.
   Borden, Katherine L. B.
   Rauscher, Frank J.
TI LIMD2 is a small LIM-only protein overexpressed in metastatic lesions
   which regulates cell motility and tumor progression by directly binding
   to and activating the integrin-linked-kinase
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Peng, Hongzhuang; Karar, Jayashree; Hou, Zhaoyuan; Herlyn, Meenhard; Caton, Andrew J.; Paterno, Christopher S.; Carolin, Alexandra S.; Speicher, David W.; Skordalakes, Emmanuel; Huang, Qihong; Rauscher, Frank J.] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA.
   [Farrooji, Mehdi Taleb Zadeh; Osborne, Michael J.] Univ Montreal, Inst Res Immunol & Canc, Dept Pathol & Cell Biol, Montreal, PQ, Canada.
   [Prokop, Jeremy W.] Med Coll Wisconsin, Human Mol & Genet Ctr, Milwaukee, WI USA.
   [McDonald, Paul C.; Dedhar, Shoukat S.] British Columbia Canc Res Ctr, Dept Integrat Oncol, Vancouver, BC V5Z 1L3, Canada.
   [He, Mei; Kebebew, Electron] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Orntoft, Torben] Aarhus Univ Hosp, Skejby, Denmark.
   [Fredericks, William; Malkowicz, Bruce] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA.
   [Fredericks, William; Malkowicz, Bruce] Vet Affairs Med Ctr, Philadelphia, PA USA.
   [Borden, Katherine L. B.] Univ Montreal, Inst Res Immunol & Canc, Dept Pathol & Cell Biol, Vancouver, PQ, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 992
DI 10.1158/1538-7445.AM2014-992
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905460
ER

PT J
AU Pieczykolan, JS
   Pieczykolan, A
   Rozga, P
   Pawlak, S
   Zerek, B
   Teska-Kaminska, M
   Michal, S
   Jaworski, A
   Erlemann, KR
   Capala, J
AF Pieczykolan, Jerzy S.
   Pieczykolan, Anna
   Rozga, Piotr
   Pawlak, Sebastian
   Zerek, Bartlomiej
   Teska-Kaminska, Malgorzata
   Michal, Szymanik
   Jaworski, Albert
   Erlemann, Karl R.
   Capala, Jacek
TI Preclinical evaluation of the novel fusion molecule with high dual
   antiangiogenic and anticancer potential
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Pieczykolan, Jerzy S.; Pieczykolan, Anna; Rozga, Piotr; Pawlak, Sebastian; Zerek, Bartlomiej; Teska-Kaminska, Malgorzata; Michal, Szymanik; Jaworski, Albert] Adamed Ltd, Warsaw, Poland.
   [Erlemann, Karl R.] InSymbiosis, Montreal, PQ, Canada.
   [Capala, Jacek] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2600
DI 10.1158/1538-7445.AM2014-2600
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903344
ER

PT J
AU Poruchynsky, MS
   Komlodi-Pasztor, E
   Wilkerson, J
   Trostel, S
   Burroto-Pichun, M
   Fojo, T
AF Poruchynsky, Marianne S.
   Komlodi-Pasztor, Edina
   Wilkerson, Julia
   Trostel, Shana
   Burroto-Pichun, Mauricio
   Fojo, Tito
TI Microtubule-targeting agents (MTAs) disrupt intracellular trafficking of
   DNA repair proteins and augment the toxicity of DNA damaging agents
   (DDAs)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Poruchynsky, Marianne S.; Komlodi-Pasztor, Edina; Wilkerson, Julia; Trostel, Shana; Burroto-Pichun, Mauricio; Fojo, Tito] NCI CCR, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-106
DI 10.1158/1538-7445.AM2014-LB-106
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205141
ER

PT J
AU Price, DK
   Chau, CH
   Figg, WD
   Till, CA
   Goodman, PJ
   Cho, Y
   Garcia, M
   Reichardt, J
   Tangen, CM
   Leach, RJ
   van Bokhoven, A
   Kristal, AR
   Thompson, IM
   Lucia, MS
AF Price, Douglas K.
   Chau, Cindy H.
   Figg, William D.
   Till, Catherine A.
   Goodman, Phyllis J.
   Cho, Yonggon
   Garcia, Marileila
   Reichardt, Juergen
   Tangen, Catherine M.
   Leach, Robin J.
   van Bokhoven, Adrie
   Kristal, Alan R.
   Thompson, Ian M.
   Lucia, M. Scott
TI Androgen receptor CAG repeat length and TMPRSS2: ETS prostate cancer
   risk: results from the Prostate Cancer Prevention Trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Price, Douglas K.; Chau, Cindy H.; Figg, William D.] NCI, Bethesda, MD 20892 USA.
   [Till, Catherine A.; Goodman, Phyllis J.; Tangen, Catherine M.; Kristal, Alan R.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Cho, Yonggon] Chonbuk Natl Univ, Sch Med, Jeonju 561756, South Korea.
   [Garcia, Marileila; van Bokhoven, Adrie; Lucia, M. Scott] Univ Colorado, Denver, CO 80202 USA.
   [Reichardt, Juergen] James Cook Univ, Townsville, Qld, Australia.
   [Leach, Robin J.; Thompson, Ian M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
RI Figg Sr, William/M-2411-2016; Cho, Yong Gon/Q-9924-2016
OI Cho, Yong Gon/0000-0003-3011-6875
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1863
DI 10.1158/1538-7445.AM2014-1863
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902080
ER

PT J
AU Purdue, MP
   Lan, Q
   Kemp, TJ
   Hildesheim, A
   Weinstein, SJ
   Albanes, D
   Pinto, LA
   Rothman, N
AF Purdue, Mark P.
   Lan, Qing
   Kemp, Troy J.
   Hildesheim, Allan
   Weinstein, Stephanie J.
   Albanes, Demetrius
   Pinto, Ligia A.
   Rothman, Nathaniel
TI Serum sCD23 and sCD30 associated with non-Hodgkin lymphoma risk as far
   as 15 to 23 years after blood collection
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Purdue, Mark P.; Lan, Qing; Hildesheim, Allan; Weinstein, Stephanie J.; Albanes, Demetrius; Rothman, Nathaniel] NCI, Rockville, MD USA.
   [Kemp, Troy J.; Pinto, Ligia A.] Frederick Natl Lab Canc Res, Frederick, MD USA.
RI Hildesheim, Allan/B-9760-2015; Purdue, Mark/C-9228-2016
OI Hildesheim, Allan/0000-0003-0257-2363; Purdue, Mark/0000-0003-1177-3108
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5073
DI 10.1158/1538-7445.AM2014-5073
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204028
ER

PT J
AU Quan, XX
   Voong, N
   Chen, WP
   Coupar, J
   Lee, S
   Petersen, DW
   Edelman, DC
   Meltzer, PS
   Montemarano, A
   Braun, M
   Vogel, J
   Van Waes, C
   Chen, Z
AF Quan, Xinxin
   Voong, Nga
   Chen, Weiping
   Coupar, Jamie
   Lee, Steven
   Petersen, David W.
   Edelman, Daniel C.
   Meltzer, Paul S.
   Montemarano, Andrew
   Braun, Martin
   Vogel, Jonathan
   Van Waes, Carter
   Chen, Zhong
TI Aberrant NF-kappa B and Notch pathways promote CD133+cancer stem cells
   in human primary cutaneous squamous cell carcinoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Quan, Xinxin; Coupar, Jamie; Lee, Steven; Van Waes, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
   [Voong, Nga; Petersen, David W.; Edelman, Daniel C.; Meltzer, Paul S.; Vogel, Jonathan] NCI, NIH, Bethesda, MD 20892 USA.
   [Chen, Weiping] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Montemarano, Andrew] Skin Canc Surg Ctr, Bethesda, MD USA.
   [Braun, Martin] Braun Dermatol Associates, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3019
DI 10.1158/1538-7445.AM2014-3019
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200026
ER

PT J
AU Rao, A
   Carithers, L
   Moore, H
AF Rao, Abhi
   Carithers, Latarsha
   Moore, Helen
TI The Biospecimen Methodological Study (BMS): Identifying best practices
   for tissue preservation and maintenance of RNA integrity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Rao, Abhi; Carithers, Latarsha; Moore, Helen] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2236
DI 10.1158/1538-7445.AM2014-2236
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902447
ER

PT J
AU Reid, JM
   Goetz, MP
   Kumar, S
   McGovern, RM
   Buhrow, SA
   Safgren, SL
   Suman, VJ
   Docktor, TJ
   Erlichman, C
   Streicher, H
   Doroshow, JH
   Collins, J
   Ames, MM
AF Reid, Joel M.
   Goetz, Matthew P.
   Kumar, Shivaani
   McGovern, Renee M.
   Buhrow, Sarah A.
   Safgren, Stephanie L.
   Suman, Vera J.
   Docktor, Travis J.
   Erlichman, Charles
   Streicher, Howard
   Doroshow, James H.
   Collins, Jerry
   Ames, Matthew M.
TI Pharmacokinetics and in vivo metabolism of Z-endoxifen: Results from two
   phase I studies in women with ER plus breast cancer, gynecologic
   malignancies and desmoids
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Reid, Joel M.; McGovern, Renee M.; Buhrow, Sarah A.; Safgren, Stephanie L.; Ames, Matthew M.] Mayo Clin, Oncol Res, Rochester, MN USA.
   [Goetz, Matthew P.; Erlichman, Charles] Mayo Clin, Med Oncol, Rochester, MN USA.
   [Kumar, Shivaani; Streicher, Howard; Collins, Jerry] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Suman, Vera J.; Docktor, Travis J.] Mayo Clin, Canc Ctr Stat, Rochester, MN USA.
   [Doroshow, James H.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4631
DI 10.1158/1538-7445.AM2014-4631
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203105
ER

PT J
AU Reinhold, WC
   Sunshine, M
   Varma, S
   Morris, J
   Kohn, K
   Doroshow, J
   Pommier, Y
AF Reinhold, William C.
   Sunshine, Margot
   Varma, Sudir
   Morris, Joel
   Kohn, Kurt
   Doroshow, James
   Pommier, Yves
TI Using CellMiner for gene expression, DNA copy number, microRNA
   transcript levels, variant status, drug activity, and their integration
   for systems pharmacology for the NCI-60
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Reinhold, William C.; Kohn, Kurt; Pommier, Yves] NCI, Bethesda, MD 20892 USA.
   [Sunshine, Margot] Syst Res & Applicat Corp, Fairfax, VA USA.
   [Varma, Sudir] HiThru Analyt, Laurel, MD USA.
   [Morris, Joel; Doroshow, James] NCI, Dev Therapeut Program, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5327
DI 10.1158/1538-7445.AM2014-5327
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204247
ER

PT J
AU Restifo, NP
AF Restifo, Nicholas P.
TI Building highly effective anti-tumor T cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Restifo, Nicholas P.] NCI, Bethesda, MD 20892 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA SY31-02
DI 10.1158/1538-7445.AM2014-SY31-02
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205469
ER

PT J
AU Roberts, KG
   Li, YJ
   Payne-Turner, D
   Zhang, JH
   Harvey, RC
   Yang, YL
   Song, GC
   Ma, J
   Chen, SC
   Cheng, JJ
   Santiago-Morales, N
   Iacobucci, I
   Devidas, M
   Chen, IM
   Reshmi, S
   Rusch, M
   Gupta, P
   Winick, NJ
   Carroll, WL
   Heerema, NA
   Carroll, AJ
   Raetz, EA
   Marcucci, G
   Bloomfield, CD
   Stock, W
   Kornblau, SM
   Paietta, E
   Pui, CH
   Jeha, S
   Downing, J
   Gerhard, DS
   Gastier-Foster, JM
   Loh, ML
   Willman, C
   Hunger, SP
   Mullighan, CG
AF Roberts, Kathryn G.
   Li, Yongjin
   Payne-Turner, Debbie
   Zhang, Jinghui
   Harvey, Richard C.
   Yang, Yung-Li
   Song, Guangchun
   Ma, Jing
   Chen, Shann-Ching
   Cheng, Jinjun
   Santiago-Morales, Natalia
   Iacobucci, Ilaria
   Devidas, Meenakshi
   Chen, I-Ming
   Reshmi, Shalini
   Rusch, Michael
   Gupta, Pankaj
   Winick, Naomi J.
   Carroll, William L.
   Heerema, Nyla A.
   Carroll, Andrew J.
   Raetz, Elizabeth A.
   Marcucci, Guido
   Bloomfield, Clara D.
   Stock, Wendy
   Kornblau, Steven M.
   Paietta, Elisabeth
   Pui, Ching-Hon
   Jeha, Sima
   Downing, James
   Gerhard, Daniela S.
   Gastier-Foster, Julie M.
   Loh, Mignon L.
   Willman, Cheryl
   Hunger, Stephen P.
   Mullighan, Charles G.
TI The genetic landscape of Ph-like acute lymphoblastic leukemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Roberts, Kathryn G.; Li, Yongjin; Payne-Turner, Debbie; Zhang, Jinghui; Yang, Yung-Li; Song, Guangchun; Ma, Jing; Chen, Shann-Ching; Cheng, Jinjun; Santiago-Morales, Natalia; Iacobucci, Ilaria; Rusch, Michael; Gupta, Pankaj; Pui, Ching-Hon; Jeha, Sima; Downing, James; Mullighan, Charles G.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
   [Harvey, Richard C.; Chen, I-Ming; Willman, Cheryl] Univ New Mexico, Albuquerque, NM 87131 USA.
   [Devidas, Meenakshi] Univ Florida, Gainesville, FL USA.
   [Reshmi, Shalini; Heerema, Nyla A.; Marcucci, Guido; Bloomfield, Clara D.; Gastier-Foster, Julie M.] Ohio State Univ, Columbus, OH 43210 USA.
   [Winick, Naomi J.] UT Southwestern Med Ctr, Dallas, TX USA.
   [Carroll, William L.; Raetz, Elizabeth A.] NYU, Inst Canc, New York, NY USA.
   [Carroll, Andrew J.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Stock, Wendy] Univ Chicago, Chicago, IL 60637 USA.
   [Kornblau, Steven M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Paietta, Elisabeth] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Gerhard, Daniela S.] NCI, Bethesda, MD 20892 USA.
   [Loh, Mignon L.] Univ Calif San Fransisco, San Francisco, CA USA.
   [Hunger, Stephen P.] Univ Colorado, Aurora, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3083
DI 10.1158/1538-7445.AM2014-3083
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200089
ER

PT J
AU Saleh, AD
   Cornelius, S
   Cheng, H
   Martin, S
   Ormanoglu, P
   Yang, XP
   Chen, Z
   VanWaes, C
AF Saleh, Anthony D.
   Cornelius, Shaleeka
   Cheng, Hui
   Martin, Scott
   Ormanoglu, Pinar
   Yang, Xinping
   Chen, Zhong
   VanWaes, Carter
TI Integrated functional RNAi screening and structural genomics identifies
   inverse co-modulators of TP53 family and NF-kB transitional activation
   as potential therapeutic targets in head and neck
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Saleh, Anthony D.; Cornelius, Shaleeka; Cheng, Hui; Yang, Xinping; Chen, Zhong; VanWaes, Carter] Natl Inst Deafness & Other Commun Disorders, Bethesda, MD USA.
   [Martin, Scott; Ormanoglu, Pinar] Natl Ctr Adv Translat Sci, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3400
DI 10.1158/1538-7445.AM2014-3400
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200400
ER

PT J
AU Santana, MC
   Kumar, A
   Kumar, V
   Alegria, AE
   Malhotra, SV
AF Santana, Michael Concepcion
   Kumar, Ajay
   Kumar, Vineet
   Alegria, Antonio E.
   Malhotra, Sanjay V.
TI Structural activity relationship studies of aza-podophyllotoxin
   derivatives on breast cancer cell line
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Santana, Michael Concepcion; Kumar, Ajay] Univ Metropolitana, San Juan, PR USA.
   [Kumar, Vineet; Malhotra, Sanjay V.] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21701 USA.
   [Alegria, Antonio E.] Univ Puerto Rico, Dept Chem, Humacao, PR USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1631
DI 10.1158/1538-7445.AM2014-1631
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901353
ER

PT J
AU Sato, N
   Asiedu, K
   Choyke, PL
AF Sato, Noriko
   Asiedu, Kingsley
   Choyke, Peter L.
TI Differential trafficking of dendritic cells after immunization
   determines establishment of systemic anti-tumor responses
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sato, Noriko; Asiedu, Kingsley; Choyke, Peter L.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2541
DI 10.1158/1538-7445.AM2014-2541
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903279
ER

PT J
AU Saud, SM
   Dzutsev, A
   Trinchieri, G
   Colburn, N
   Young, MR
   Kim, Y
AF Saud, Shakir M.
   Dzutsev, Amiran
   Trinchieri, Giorgio
   Colburn, Nancy
   Young, Matthew R.
   Kim, Young
TI To dine with red wine: Systems approach to studying resveratrol's
   protection against inflammatory colorectal cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Saud, Shakir M.; Dzutsev, Amiran; Trinchieri, Giorgio; Colburn, Nancy; Young, Matthew R.] NCI, NIH, Frederick, MD 21701 USA.
   [Kim, Young] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4118
DI 10.1158/1538-7445.AM2014-4118
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202100
ER

PT J
AU Sayers, TJ
   de Kluyver, R
   Kaddoura, M
   Stauffer, J
   Tewary, P
   Brooks, AD
AF Sayers, Thomas J.
   de Kluyver, Rachel
   Kaddoura, Marcella
   Stauffer, Jim
   Tewary, Poonam
   Brooks, Alan D.
TI Can Nanog activity identify aggressive breast cancer stem cell
   populations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sayers, Thomas J.; Tewary, Poonam; Brooks, Alan D.] Leidos Biomed Res Inc, Frederick, MD USA.
   [de Kluyver, Rachel; Kaddoura, Marcella; Stauffer, Jim] NCI, Frederick, MD 21701 USA.
RI Sayers, Thomas/G-4859-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3876
DI 10.1158/1538-7445.AM2014-3876
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201364
ER

PT J
AU Seabloom, D
   Galbraith, A
   Wuertz, B
   Haynes, A
   Antonides, J
   Fujita, A
   Steele, V
   Wattenberg, L
   Ondrey, FG
AF Seabloom, Donna
   Galbraith, Art
   Wuertz, Beverly
   Haynes, Anna
   Antonides, Jenny
   Fujita, Alisha
   Steele, Vernon
   Wattenberg, Lee
   Ondrey, Frank G.
TI Efficacy of aerosolized pioglitazone in lung carcinogenesis in A/J mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Seabloom, Donna; Galbraith, Art; Wuertz, Beverly; Haynes, Anna; Antonides, Jenny; Fujita, Alisha; Wattenberg, Lee; Ondrey, Frank G.] Univ Minnesota, Minneapolis, MN USA.
   [Steele, Vernon] NCI, Div Canc Prevent, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2140
DI 10.1158/1538-7445.AM2014-2140
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902352
ER

PT J
AU Seabloom, D
   Galbraith, A
   Haynes, A
   Antonides, J
   Fujita, A
   Wuertz, BR
   Steele, V
   Ondrey, F
   Wattenberg, L
AF Seabloom, Donna
   Galbraith, Arthur
   Haynes, Anna
   Antonides, Jenny
   Fujita, Alisha
   Wuertz, Beverly R.
   Steele, Vernon
   Ondrey, Frank
   Wattenberg, Lee
TI Effects of talactoferrin on lung adenoma prevention in A/J mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Seabloom, Donna; Galbraith, Arthur; Haynes, Anna; Antonides, Jenny; Fujita, Alisha; Wuertz, Beverly R.; Ondrey, Frank; Wattenberg, Lee] Univ Minnesota, Minneapolis, MN USA.
   [Steele, Vernon] NCI, Div Canc Prevent, NIH, Rockford, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2129
DI 10.1158/1538-7445.AM2014-2129
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902342
ER

PT J
AU Seow, WJ
   Cawthon, R
   Purdue, M
   Hu, W
   Gao, YT
   Huang, WY
   Weinstein, SJ
   Ji, BT
   Virtamo, J
   Hosgood, D
   Bassig, B
   Shu, XO
   Cai, QY
   Xiang, YB
   Min, S
   Chow, WH
   Berndt, S
   Kim, C
   Lim, U
   Albanes, D
   Caporaso, NE
   Chanock, S
   Zheng, W
   Rothman, N
   Lan, Q
AF Seow, Wei Jie
   Cawthon, Richard
   Purdue, Mark
   Hu, Wei
   Gao, Yu-Tang
   Huang, Wen-Yi
   Weinstein, Stephanie J.
   Ji, Bu-Tian
   Virtamo, Jarmo
   Hosgood, Dean
   Bassig, Bryan
   Shu, Xiaoou
   Cai, Qiuyin
   Xiang, Yongbin
   Min, Shen
   Chow, Wong-Ho
   Berndt, Sonja
   Kim, Christopher
   Lim, Unhee
   Albanes, Demetrius
   Caporaso, Neil E.
   Chanock, Stephen
   Zheng, Wei
   Rothman, Nathaniel
   Lan, Qing
TI Telomere length in white blood cell DNA and lung cancer: a pooled
   analysis of three prospective cohorts
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Seow, Wei Jie; Purdue, Mark; Hu, Wei; Huang, Wen-Yi; Weinstein, Stephanie J.; Ji, Bu-Tian; Bassig, Bryan; Berndt, Sonja; Kim, Christopher; Albanes, Demetrius; Caporaso, Neil E.; Chanock, Stephen; Rothman, Nathaniel; Lan, Qing] NCI, Rockville, MD USA.
   [Cawthon, Richard] Univ Utah, Salt Lake City, UT USA.
   [Gao, Yu-Tang; Xiang, Yongbin] Shanghai Canc Inst, Shanghai, Peoples R China.
   [Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Hosgood, Dean] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Shu, Xiaoou; Cai, Qiuyin] Vanderbilt Univ Sch Med, Nashville, TN USA.
   [Shu, Xiaoou; Cai, Qiuyin] Vanderbilt Ingram Canc Ctr, Nashville, TN USA.
   [Min, Shen] Caromont Hlth, Gastonia, NC USA.
   [Chow, Wong-Ho] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Lim, Unhee] Univ Hawaii Canc Ctr, Honolulu, HI USA.
   [Zheng, Wei] Vanderbilt Univ Sch Med, Nashville, TN USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4160
DI 10.1158/1538-7445.AM2014-4160
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202140
ER

PT J
AU Sherman, ME
   Ichikawa, L
   Miglioretti, D
   Vacek, P
   Tice, J
   Pfeiffer, R
   Kerlikowske, K
   Gierach, G
AF Sherman, Mark E.
   Ichikawa, Laura
   Miglioretti, Diana
   Vacek, Pamela
   Tice, Jeffrey
   Pfeiffer, Ruth
   Kerlikowske, Karla
   Gierach, Gretchen
TI Absolute breast cancer risk according to three risk prediction models:
   Inverse associations with risk of death and poor prognostic features
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sherman, Mark E.] NCI, DCP, Bethesda, MD 20892 USA.
   [Ichikawa, Laura] Grp Hlth Res Inst, Seattle, WA USA.
   [Miglioretti, Diana] UC Davis Sch Med, Bethesda, MD USA.
   [Vacek, Pamela] Univ Vermont, Coll Med, Burlington, VT USA.
   [Tice, Jeffrey; Kerlikowske, Karla] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Pfeiffer, Ruth; Gierach, Gretchen] NCI, DCEG, Bethesda, MD 20892 USA.
RI Gierach, Gretchen/E-1817-2016
OI Gierach, Gretchen/0000-0002-0165-5522
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 268
DI 10.1158/1538-7445.AM2014-268
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903429
ER

PT J
AU Shi, JX
   Yang, XHR
   Ballew, B
   Rotunno, M
   Calista, D
   Fargnoli, MC
   Ghiorzo, P
   Bressac-de Paillerets, B
   Nagore, E
   Hua, X
   Hyland, P
   Yin, JH
   Vallabhaneni, H
   Chai, WH
   Ravichandran, S
   Eggermont, A
   Lathrop, M
   Peris, K
   Bianchi-Scarra, G
   Landi, G
   Savage, S
   Sampson, J
   He, J
   Yeager, M
   Goldin, L
   Demenais, F
   Chanock, S
   Tucker, M
   Goldstein, A
   Liu, Y
   Landi, MT
AF Shi, Jianxin
   Yang, Xiaohong R.
   Ballew, Bari
   Rotunno, Melissa
   Calista, Donato
   Fargnoli, Maria C.
   Ghiorzo, Paola
   Bressac-de Paillerets, Brigitte
   Nagore, Eduardo
   Hua, Xing
   Hyland, Paula
   Yin, Jinhu
   Vallabhaneni, Haritha
   Chai, Weihang
   Ravichandran, Sarangan
   Eggermont, Alexander
   Lathrop, Mark
   Peris, Ketty
   Bianchi-Scarra, Giovanna
   Landi, Giorgio
   Savage, Sharon
   Sampson, Joshua
   He, Ji
   Yeager, Meredith
   Goldin, Lynn
   Demenais, Florence
   Chanock, Stephen
   Tucker, Margaret
   Goldstein, Alisa
   Liu, Yie
   Landi, Maria T.
CA NCI DCEG Canc Sequencing Working
TI Exome sequencing identified POT1, a telomere shelterin gene, as a major
   susceptibility gene for familial cutaneous malignant melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shi, Jianxin; Yang, Xiaohong R.; Ballew, Bari; Rotunno, Melissa; Hua, Xing; Hyland, Paula; Savage, Sharon; Sampson, Joshua; Goldin, Lynn; Chanock, Stephen; Tucker, Margaret; Goldstein, Alisa; Landi, Maria T.] NCI, NIH, DHHS, Bethesda, MD 20892 USA.
   [Calista, Donato; Landi, Giorgio] Maurizio Bufalini Hosp, Cesena, Italy.
   [Fargnoli, Maria C.; Peris, Ketty] Univ Aquila, I-67100 Laquila, Italy.
   [Ghiorzo, Paola; Bianchi-Scarra, Giovanna] Univ Genoa, I-16126 Genoa, Italy.
   [Bressac-de Paillerets, Brigitte; Eggermont, Alexander] Gustave Roussy, Villejuif, France.
   [Nagore, Eduardo] Inst Valenciano Oncol, Valencia, Spain.
   [Yin, Jinhu; Vallabhaneni, Haritha; Liu, Yie] NIA, NIH, DHHS, Bethesda, MD 20892 USA.
   [Chai, Weihang] Washington State Univ, Spokane, WA USA.
   [Ravichandran, Sarangan; He, Ji; Yeager, Meredith] NCI, NIH, DHHS, Frederick, MD 21701 USA.
   [Lathrop, Mark] McGill Univ, Montreal, PQ, Canada.
   [Demenais, Florence] INSERM, F-75654 Paris 13, France.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 941
DI 10.1158/1538-7445.AM2014-941
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905405
ER

PT J
AU Shi, JX
   Marconett, C
   Duan, JB
   Hyland, P
   Li, P
   Wang, ZM
   Wheeler, W
   Campan, M
   Huang, J
   Zhou, WY
   Triche, T
   Amundadottir, L
   Hutchinson, A
   Chen, PH
   Zhou, BY
   Chung, B
   Bertazzi, PA
   Bergen, AW
   Freedman, M
   Lee, D
   Siegmund, K
   Warner, AC
   Berman, B
   Pesatori, AC
   Borok, Z
   Consonni, D
   Chatterjee, N
   Tucker, M
   Caporaso, N
   Chanock, SJ
   Laird-Offringa, IA
   Landi, MT
AF Shi, Jianxin
   Marconett, Crystal
   Duan, Jubao
   Hyland, Paula
   Li, Peng
   Wang, Zhaoming
   Wheeler, William
   Campan, Mihaela
   Huang, Jing
   Zhou, Weiyin
   Triche, Tim
   Amundadottir, Laufey
   Hutchinson, Amy
   Chen, Po-Han
   Zhou, Beiyun
   Chung, Brian
   Bertazzi, Pier Alberto
   Bergen, Andrew W.
   Freedman, Mathew
   Lee, Diane
   Siegmund, Kim
   Warner, Andrew Clay
   Berman, Ben
   Pesatori, Angela C.
   Borok, Zea
   Consonni, Dario
   Chatterjee, Nilanjan
   Tucker, Margaret
   Caporaso, Neil
   Chanock, Stephen J.
   Laird-Offringa, Ite A.
   Landi, Maria Teresa
TI Characterizing the genetic basis of methylome diversity in
   histologically normal human lung tissue
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shi, Jianxin; Hyland, Paula; Li, Peng; Wang, Zhaoming; Wheeler, William; Huang, Jing; Zhou, Weiyin; Amundadottir, Laufey; Hutchinson, Amy; Chatterjee, Nilanjan; Tucker, Margaret; Caporaso, Neil; Chanock, Stephen J.; Landi, Maria Teresa] NCI, Bethesda, MD 20892 USA.
   [Marconett, Crystal; Campan, Mihaela; Triche, Tim; Chen, Po-Han; Zhou, Beiyun; Chung, Brian; Lee, Diane; Siegmund, Kim; Berman, Ben; Borok, Zea; Laird-Offringa, Ite A.] Univ So Calif, Los Angeles, CA USA.
   [Duan, Jubao] Univ Chicago, Chicago, IL 60637 USA.
   [Bertazzi, Pier Alberto; Pesatori, Angela C.; Consonni, Dario] Univ Milan, Milan, Italy.
   [Bergen, Andrew W.] SRI Int, Menlo Pk, CA 94025 USA.
   [Freedman, Mathew] Broad Inst, Baltimore, MD USA.
   [Freedman, Mathew] Dana Farber Canc Inst, Baltimore, MD USA.
   [Warner, Andrew Clay] Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 287
DI 10.1158/1538-7445.AM2014-287
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904134
ER

PT J
AU Shi, TJ
   He, JT
   Wu, CC
   Fillmore, TL
   Schepmoes, AA
   Rubin, M
   Siddiqui, J
   Wei, J
   Chinnaiyan, A
   Liu, A
   Smith, RD
   Kagan, J
   Srivastava, S
   Rodland, KD
   Qian, WJ
   Liu, T
   Camp, DG
AF Shi, Tujin
   He, Jintang
   Wu, Chaochao
   Fillmore, Thomas L.
   Schepmoes, Athena A.
   Rubin, Mark
   Siddiqui, Javed
   Wei, John
   Chinnaiyan, Arul
   Liu, Alvin
   Smith, Richard D.
   Kagan, Jacob
   Srivastava, Sudhir
   Rodland, Karin D.
   Qian, Wei-Jun
   Liu, Tao
   Camp, David G.
TI An antibody-independent, complementary SRM strategy for ultrasensitive
   and multiplexed quantification of cancer biomarker candidates
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shi, Tujin; He, Jintang; Wu, Chaochao; Fillmore, Thomas L.; Schepmoes, Athena A.; Smith, Richard D.; Rodland, Karin D.; Qian, Wei-Jun; Liu, Tao; Camp, David G.] Pacific NW Natl Lab, Richland, WA 99352 USA.
   [Rubin, Mark] Weill Cornell Med Coll, New York, NY USA.
   [Siddiqui, Javed; Wei, John; Chinnaiyan, Arul] Univ Michigan Med Sch, Ann Arbor, MI USA.
   [Liu, Alvin] Univ Washington, Seattle, WA 98195 USA.
   [Kagan, Jacob; Srivastava, Sudhir] NCI, Rockville, MD USA.
RI Smith, Richard/J-3664-2012
OI Smith, Richard/0000-0002-2381-2349
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2483
DI 10.1158/1538-7445.AM2014-2483
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903216
ER

PT J
AU Shiels, MS
   Katki, HA
   Hildesheim, A
   Pfeiffer, RM
   Engels, EA
   Williams, MC
   Kemp, TJ
   Caporaso, NE
   Pinto, LA
   Chaturvedi, AK
AF Shiels, Meredith S.
   Katki, Hormuzd A.
   Hildesheim, Allan
   Pfeiffer, Ruth M.
   Engels, Eric A.
   Williams, Marcus C.
   Kemp, Troy J.
   Caporaso, Neil E.
   Pinto, Ligia A.
   Chaturvedi, Anil K.
TI Circulating inflammation markers and subsequent lung cancer risk: A
   discovery and replication study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shiels, Meredith S.; Katki, Hormuzd A.; Hildesheim, Allan; Pfeiffer, Ruth M.; Engels, Eric A.; Caporaso, Neil E.; Chaturvedi, Anil K.] NCI, Bethesda, MD 20892 USA.
   [Williams, Marcus C.; Kemp, Troy J.; Pinto, Ligia A.] Frederick Natl Lab Canc Res, Frederick, MD USA.
RI Hildesheim, Allan/B-9760-2015
OI Hildesheim, Allan/0000-0003-0257-2363
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2920
DI 10.1158/1538-7445.AM2014-2920
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904189
ER

PT J
AU Shimbo, T
   Du, Y
   Grimm, SA
   Dhasarathy, A
   Mav, D
   Shah, RR
   Shi, HD
   Wade, PA
AF Shimbo, Takashi
   Du, Ying
   Grimm, Sara A.
   Dhasarathy, Archana
   Mav, Deepak
   Shah, Ruchir R.
   Shi, Huidong
   Wade, Paul A.
TI Mbd3 localizes at promoters, gene bodies and enhancers of active genes
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shimbo, Takashi; Du, Ying; Grimm, Sara A.; Dhasarathy, Archana; Wade, Paul A.] NIEHS, NIH, Res Triangle Pk, NC USA.
   [Mav, Deepak; Shah, Ruchir R.] SRA Int Inc, Durham, NC USA.
   [Shi, Huidong] Georgia Hlth Sci Univ, Augusta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 405
DI 10.1158/1538-7445.AM2014-405
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904371
ER

PT J
AU Shukla, S
   Chufan, EE
   Singh, S
   Skoumbourdis, AP
   Kapoor, K
   Boxer, MB
   Duveau, DY
   Thomas, CJ
   Talele, TT
   Ambudkar, SV
AF Shukla, Suneet
   Chufan, Eduardo E.
   Singh, Satyakam
   Skoumbourdis, Amanda P.
   Kapoor, Khyati
   Boxer, Matthew B.
   Duveau, Damien Y.
   Thomas, Craig J.
   Talele, Tanaji T.
   Ambudkar, Suresh V.
TI Identification of a binding site for the tyrosine kinase inhibitor
   Nilotinib on the human ABC drug transporter, P-glycoprotein as
   determined by 3D-QSAR, molecular docking and mutational mapping
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Shukla, Suneet; Chufan, Eduardo E.; Kapoor, Khyati; Ambudkar, Suresh V.] Natl Canc Inst, Bethesda, MD USA.
   [Singh, Satyakam; Talele, Tanaji T.] St Johns Univ, Queens, NY USA.
   [Skoumbourdis, Amanda P.; Boxer, Matthew B.; Duveau, Damien Y.; Thomas, Craig J.] Natl Ctr Adv Translat Sci, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-224
DI 10.1158/1538-7445.AM2014-LB-224
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205258
ER

PT J
AU Singh, SV
   Antony, ML
   Lee, J
   Hahm, ER
   Kim, SH
   Romero, G
   Marcus, AI
   Yang, Z
   Kumari, V
   Ji, XH
   Vowell, CL
   Wipf, P
   Uechi, GT
   Yates, NA
AF Singh, Shivendra V.
   Antony, Marie Lue
   Lee, Joomin
   Hahm, Eun-Ryeong
   Kim, Su-Hyeong
   Romero, Guillermo
   Marcus, Adam I.
   Yang, Zhen
   Kumari, Vandana
   Ji, Xinhua
   Vowell, Courtney L.
   Wipf, Peter
   Uechi, Guy T.
   Yates, Nathan A.
TI Withaferin A downregulates tubulins and covalently binds beta-tubulin at
   cysteine-303 in human breast cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Singh, Shivendra V.; Antony, Marie Lue; Lee, Joomin; Hahm, Eun-Ryeong; Kim, Su-Hyeong; Romero, Guillermo; Vowell, Courtney L.; Wipf, Peter; Uechi, Guy T.; Yates, Nathan A.] Univ Pittsburgh, Pittsburgh, PA USA.
   [Marcus, Adam I.; Yang, Zhen] Emory Univ, Atlanta, GA 30322 USA.
   [Kumari, Vandana; Ji, Xinhua] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 228
DI 10.1158/1538-7445.AM2014-228
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902496
ER

PT J
AU Skibola, CF
   Berndt, SI
   Cerhan, JR
   Wang, ZM
   Vijai, J
   Conde, L
   de Bakker, P
   Wang, SS
   Vajdic, CM
   Birmann, BM
   Slager, SL
   Mckay, J
   Bracci, PM
   Nieters, A
   Lan, Q
   Brooks-Wilson, AR
   Linet, MS
   Albanes, D
   Spinelli, JJ
   Vermeulen, RCH
   Purdue, MP
   Yaeger, M
   Teras, LR
   de Sanjose, S
   Monnereau, A
   Crouch, S
   Foo, JN
   Hjalgrim, H
   Severi, G
   Link, BK
   Bertrand, KA
   Zhang, YW
   Smedby, KE
   Chanock, SJ
   Rothman, N
AF Skibola, Christine F.
   Berndt, Sonja I.
   Cerhan, James R.
   Wang, Zhaoming
   Vijai, Joseph
   Conde, Lucia
   de Bakker, Paul
   Wang, Sophia S.
   Vajdic, Claire M.
   Birmann, Brenda M.
   Slager, Susan L.
   Mckay, James
   Bracci, Paige M.
   Nieters, Alexandra
   Lan, Qing
   Brooks-Wilson, Angela R.
   Linet, Martha S.
   Albanes, Demetrius
   Spinelli, John J.
   Vermeulen, Roel C. H.
   Purdue, Mark P.
   Yaeger, Meredith
   Teras, Lauren R.
   de Sanjose, Silvia
   Monnereau, Alain
   Crouch, Simon
   Foo, Jia Nee
   Hjalgrim, Henrik
   Severi, Gianluca
   Link, Brian K.
   Bertrand, Kimberly A.
   Zhang, Yawei
   Smedby, Karin E.
   Chanock, Stephen J.
   Rothman, Nathaniel
CA NHL GWAS Consortium
TI Meta-analysis of genome-wide association studies identifies novel
   susceptibility loci for follicular lymphoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Skibola, Christine F.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Berndt, Sonja I.; Lan, Qing; Linet, Martha S.; Albanes, Demetrius; Purdue, Mark P.; Chanock, Stephen J.; Rothman, Nathaniel] NCI, Bethesda, MD 20892 USA.
   [Cerhan, James R.; Slager, Susan L.] Mayo Clin, Rochester, MN USA.
   [Wang, Zhaoming; Yaeger, Meredith] NCI, Canc Genom Res Lab, Bethesda, MD 20892 USA.
   [Vijai, Joseph] Mem Sloan Kettering Canc Ctr, New York, NY USA.
   [de Bakker, Paul] Univ Med Ctr, Utrecht, Netherlands.
   [Wang, Sophia S.] City Hope Beckman Res Inst, Duarte, CA USA.
   [Vajdic, Claire M.] Univ New S Wales, Sydney, NSW 2052, Australia.
   [Birmann, Brenda M.; Bertrand, Kimberly A.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Birmann, Brenda M.; Bertrand, Kimberly A.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
   [Mckay, James] Int Agcy Res Canc, F-69372 Lyon, France.
   [Bracci, Paige M.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Nieters, Alexandra] Univ Med Ctr Freiburg, Freiburg, Germany.
   [Brooks-Wilson, Angela R.] Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada.
   [Spinelli, John J.] BC Canc Agcy, Vancouver, BC, Canada.
   [Vermeulen, Roel C. H.] Univ Utrecht, NL-3508 TC Utrecht, Netherlands.
   [Teras, Lauren R.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
   [de Sanjose, Silvia] Inst Catala Oncol, Barcelona, Spain.
   [Monnereau, Alain] INSERM, F-75654 Paris 13, France.
   [Crouch, Simon] Univ York, York YO10 5DD, N Yorkshire, England.
   [Foo, Jia Nee] Agcy Sci Technol & Res, Singapore, Singapore.
   [Hjalgrim, Henrik] Statens Serum Inst, Copenhagen, Denmark.
   [Severi, Gianluca] Canc Council Victoria, Melbourne, Vic, Australia.
   [Link, Brian K.] Univ Iowa, Iowa City, IA 52242 USA.
   [Zhang, Yawei] Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA.
   [Smedby, Karin E.] Karolinska Inst, S-10401 Stockholm, Sweden.
RI Conde, Lucia/D-9295-2011; Brooks-Wilson, Angela/E-9399-2012; Purdue,
   Mark/C-9228-2016; Foo, Jia Nee/D-6069-2014; de Sanjose Llongueras,
   Silvia/H-6339-2014
OI Brooks-Wilson, Angela/0000-0003-1009-6408; Purdue,
   Mark/0000-0003-1177-3108; Foo, Jia Nee/0000-0001-9899-2308; 
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5072
DI 10.1158/1538-7445.AM2014-5072
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204027
ER

PT J
AU Skrypek, NG
   Achyut, BR
   Hollander, C
   Yang, L
AF Skrypek, Nicolas G.
   Achyut, B. R.
   Hollander, Christine
   Yang, Li
TI DNA methyltransferase 3B as a mediator in cancer associated inflammation
   and progression
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Skrypek, Nicolas G.; Achyut, B. R.; Hollander, Christine; Yang, Li] NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4840
DI 10.1158/1538-7445.AM2014-4840
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203307
ER

PT J
AU Smith, M
   Kang, M
   Reynolds, P
   Gorlick, R
   Kolb, A
   Maris, J
   Lock, R
   Carol, H
   Keir, S
   Billups, C
   Kurmasheva, R
   Houghton, P
AF Smith, Malcolm
   Kang, Min
   Reynolds, Patrick
   Gorlick, Richard
   Kolb, Anders
   Maris, John
   Lock, Richard
   Carol, Hernan
   Keir, Stephen
   Billups, Catherine
   Kurmasheva, Raushan
   Houghton, Peter
TI Pediatric preclinical testing program (PPTP) evaluation of BMN 673, an
   inhibitor of poly-adp ribose polymerase (PARP), with temozolomide (TMZ)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Smith, Malcolm] CTEP NCI, Bethesda, MD USA.
   [Kang, Min; Reynolds, Patrick] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Gorlick, Richard] Childrens Hosp Montefiore, Bronx, NY USA.
   [Kolb, Anders] AI duPont Hosp, Wilmington, DE USA.
   [Maris, John] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Lock, Richard; Carol, Hernan] Childrens Canc Ctr Inst, Randwick, NSW, Australia.
   [Keir, Stephen] Duke Univ, Durham, NC USA.
   [Billups, Catherine] St Jude Childrens Res Hosp, Memphis, TN USA.
   [Kurmasheva, Raushan; Houghton, Peter] Nationwide Childrens Hosp, Ctr Childhood Canc, Columbus, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3969
DI 10.1158/1538-7445.AM2014-3969
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201453
ER

PT J
AU Song, NY
   Willette-Brown, J
   Dalta, M
   Hu, YL
AF Song, Na-Young
   Willette-Brown, Jami
   Dalta, Mahesh
   Hu, Yinling
TI Role of IKK alpha in K-ras-driven lung carcinogenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Song, Na-Young; Willette-Brown, Jami; Dalta, Mahesh; Hu, Yinling] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 931
DI 10.1158/1538-7445.AM2014-931
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905394
ER

PT J
AU Soto-Pantoja, DR
   Sipes, JM
   Ghosh, A
   Merino, MJ
   Roberts, DD
AF Soto-Pantoja, David R.
   Sipes, John M.
   Ghosh, Arunima
   Merino, Maria J.
   Roberts, David D.
TI Therapeutic targeting of CD47 regulates cell bioenergetics and autophagy
   to reduce breast tumor growth and protect against anthracycline-mediated
   cardiac toxicity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Soto-Pantoja, David R.; Sipes, John M.; Ghosh, Arunima; Merino, Maria J.; Roberts, David D.] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA.
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2434
DI 10.1158/1538-7445.AM2014-2434
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903162
ER

PT J
AU Sourbier, C
   Scroggins, B
   Mannes, PZ
   Beutler, JA
   Linehan, WM
   Neckers, L
AF Sourbier, Carole
   Scroggins, Brad
   Mannes, Philip Z.
   Beutler, John A.
   Linehan, W. Marston
   Neckers, Len
TI Deciphering the targets and mechanism of action of the natural product
   Tonantzitlolone in clear cell renal cell carcinomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sourbier, Carole; Scroggins, Brad; Mannes, Philip Z.; Beutler, John A.; Linehan, W. Marston; Neckers, Len] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3202
DI 10.1158/1538-7445.AM2014-3202
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200206
ER

PT J
AU Spencer, SD
   Rosen, LS
   Gordon, MS
   Robert, F
   Matei, D
   Peer, CJ
   Adams, B
   Alvarez, D
   Seon, BK
   Theuer, CP
   Figg, WD
AF Spencer, Shawn D.
   Rosen, Lee S.
   Gordon, Michael S.
   Robert, Francisco
   Matei, Daniela
   Peer, Cody J.
   Adams, Bonne
   Alvarez, Delia
   Seon, Ben K.
   Theuer, Charles P.
   Figg, W. Douglas
TI Differences in pharmacokinetics of TRC105 (anti-endoglin antibody) when
   administered as a single agent versus in combination with bevacizumab
   (Bev)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Spencer, Shawn D.] Fairleigh Dickinson Univ, Madison, NJ USA.
   [Rosen, Lee S.] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Gordon, Michael S.] Pinnacle Oncol Hematol, Scottsdale, AZ USA.
   [Robert, Francisco] Univ Alabama Birmingham, Birmingham, AL USA.
   [Matei, Daniela] Indiana Univ, Indianapolis, IN 46204 USA.
   [Peer, Cody J.; Figg, W. Douglas] NCI, Bethesda, MD 20892 USA.
   [Adams, Bonne; Alvarez, Delia; Theuer, Charles P.] TRACON Pharmaceut Inc, San Diego, CA USA.
   [Seon, Ben K.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
RI Figg Sr, William/M-2411-2016
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA CT222
DI 10.1158/1538-7445.AM2014-CT222
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205050
ER

PT J
AU Spitzner, M
   Roesler, B
   Bielfeld, C
   Herzberg, C
   Emons, G
   Gaedcke, J
   Rave-Frank, M
   Beissbarth, T
   Ried, T
   Ghadimi, BM
   Grade, M
AF Spitzner, Melanie
   Roesler, Birte
   Bielfeld, Christian
   Herzberg, Carolin
   Emons, Georg
   Gaedcke, Jochen
   Rave-Fraenk, Margret
   Beissbarth, Tim
   Ried, Thomas
   Ghadimi, B. Michael
   Grade, Marian
TI Targeting STAT3 in vitro and in vivo reveals a novel therapeutic
   strategy to sensitize colorectal cancer cells to chemoradiotherapy
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Spitzner, Melanie; Roesler, Birte; Bielfeld, Christian; Herzberg, Carolin; Emons, Georg; Gaedcke, Jochen; Rave-Fraenk, Margret; Beissbarth, Tim; Ghadimi, B. Michael; Grade, Marian] Univ Med Ctr Gottingen, Gottingen, Germany.
   [Ried, Thomas] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 855
DI 10.1158/1538-7445.AM2014-855
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905313
ER

PT J
AU Srivastava, AK
   Hollingshead, MG
   Govindharajulu, JP
   Covey, JM
   Liston, D
   Peggins, J
   Bottaro, DP
   Wright, JJ
   Kinders, RJ
   Tomaszewski, JE
   Doroshow, JH
   Parchment, RE
AF Srivastava, Apurva K.
   Hollingshead, Melinda G.
   Govindharajulu, Jeevan P.
   Covey, Joseph M.
   Liston, Dane
   Peggins, James
   Bottaro, Donald P.
   Wright, John J.
   Kinders, Robert J.
   Tomaszewski, Joseph E.
   Doroshow, James H.
   Parchment, Ralph E.
TI Met target inhibition-guided efficacy in preclinical models
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Srivastava, Apurva K.; Govindharajulu, Jeevan P.; Kinders, Robert J.; Parchment, Ralph E.] Leidos Biomed Res Inc, Lab Human Toxicol & Pharmacol, Frederick, MD USA.
   [Hollingshead, Melinda G.] NCI, Frederick, MD 21701 USA.
   [Covey, Joseph M.; Liston, Dane; Peggins, James; Wright, John J.] NCI, Rockville, MD USA.
   [Bottaro, Donald P.; Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3691
DI 10.1158/1538-7445.AM2014-3691
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201183
ER

PT J
AU Sun, B
   Wang, Y
   Kota, K
   Shi, Y
   Makambi, KH
   Loffredo, CA
   Shields, PG
   Harris, CC
   Zheng, YL
AF Sun, Bing
   Wang, Ying
   Kota, Krishna
   Shi, Yaru
   Makambi, Kepher H.
   Loffredo, Christopher A.
   Shields, Peter G.
   Harris, Curtis C.
   Zheng, Yun-Ling
TI Autosome instability and loss of chromosome Y in blood lymphocytes
   predict lung cancer risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sun, Bing; Wang, Ying; Kota, Krishna; Shi, Yaru; Makambi, Kepher H.; Loffredo, Christopher A.; Zheng, Yun-Ling] Lombardi Comp Canc Ctr, Washington, DC USA.
   [Shields, Peter G.] Ohio State Univ Wexner Med Ctr, Columbus, OH USA.
   [Harris, Curtis C.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4157
DI 10.1158/1538-7445.AM2014-4157
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202137
ER

PT J
AU Sung, HN
   Rosenberg, PS
   Chen, WQ
   Hartman, M
   Lim, WY
   Chia, KS
   Mang, OWK
   Tse, SLA
   Anderson, WF
   Yang, XHR
AF Sung, Hyuna
   Rosenberg, Philip S.
   Chen, Wan-Qing
   Hartman, Mikael
   Lim, Wei-Yen
   Chia, Kee Seng
   Mang, Oscar Wai-Kong
   Tse, Shelly Lap-ah
   Anderson, William F.
   Yang, Xiaohong R.
TI Differential cohort effect on early- and late-onset breast cancer
   incidence among Chinese women in different populations
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Sung, Hyuna; Rosenberg, Philip S.; Chen, Wan-Qing; Anderson, William F.; Yang, Xiaohong R.] NCI, Rockville, MD USA.
   [Hartman, Mikael; Lim, Wei-Yen; Chia, Kee Seng] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore.
   [Mang, Oscar Wai-Kong] Hong Kong Canc Registry, Hosp Author, Hong Kong, Hong Kong, Peoples R China.
   [Tse, Shelly Lap-ah] Chinese Univ Hong Kong, Div Occupat & Environm Hlth, JC Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.
RI Hartman, Mikael/B-4324-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-288
DI 10.1158/1538-7445.AM2014-LB-288
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205320
ER

PT J
AU Takaku, M
   Adomas, A
   Grimm, SA
   Takashi, S
   Wade, PA
AF Takaku, Motoki
   Adomas, Aleksandra
   Grimm, Sara A.
   Takashi, Shimbo
   Wade, Paul A.
TI GATA3 mutations in breast cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Takaku, Motoki; Adomas, Aleksandra; Grimm, Sara A.; Takashi, Shimbo; Wade, Paul A.] NIEHS, Res Triangle Pk, NC 27709 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 475
DI 10.1158/1538-7445.AM2014-475
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904439
ER

PT J
AU Tandle, AT
   Tofilon, P
   Camphausen, K
AF Tandle, Anita T.
   Tofilon, Philip
   Camphausen, Kevin
TI mTOR kinase inhibition enhances radiosensitivity in glioblastoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tandle, Anita T.; Tofilon, Philip; Camphausen, Kevin] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4906
DI 10.1158/1538-7445.AM2014-4906
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203370
ER

PT J
AU Tang, NM
   Zhang, C
   Noraian, C
   Wali, A
   Pass, H
   Harbut, M
   Zhang, XB
AF Tang, Naimei
   Zhang, Crystal
   Noraian, Cyndi
   Wali, Anil
   Pass, Harvey
   Harbut, Michael
   Zhang, Xinbo
TI The effect of Hoechst 33342 and Hoechst 33258 on side population (SP)
   cells or stem cell-like population
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tang, Naimei] UT Austin, Austin, TX USA.
   [Zhang, Crystal; Zhang, Xinbo] Wayne State Univ, Detroit, MI USA.
   [Noraian, Cyndi; Harbut, Michael] Karmanos Canc Inst, Detroit, MI USA.
   [Wali, Anil] NIH, Bethesda, MD 20892 USA.
   [Pass, Harvey] Langone Med Ctr, New York, NY USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1921
DI 10.1158/1538-7445.AM2014-1921
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902136
ER

PT J
AU Tang, WH
   Wang, HS
   Claudio, E
   Siebenlist, U
AF Tang, Wanhu
   Wang, Hongshan
   Claudio, Estefania
   Siebenlist, Ulrich
TI The pro-inflammatory role of the putative oncogene Bcl-3
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tang, Wanhu; Wang, Hongshan; Claudio, Estefania; Siebenlist, Ulrich] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1661
DI 10.1158/1538-7445.AM2014-1661
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901383
ER

PT J
AU Taylor, IC
   Hutt-Cabezas, M
   Weingart, M
   Warren, K
   Chang, H
   Nazarian, J
   Eberhart, CG
   Raabe, EH
AF Taylor, Isabella C.
   Hutt-Cabezas, Marianne
   Weingart, Melanie
   Warren, Kathy
   Chang, Howard
   Nazarian, Javad
   Eberhart, Charles G.
   Raabe, Eric H.
TI Dual targeting of mTOR and Notch disrupts growth and promotes apoptosis
   in diffuse intrinsic pontine glioma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Taylor, Isabella C.; Hutt-Cabezas, Marianne; Weingart, Melanie; Eberhart, Charles G.; Raabe, Eric H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Warren, Kathy] NIH, Bethesda, MD USA.
   [Chang, Howard] Michigan State Univ, E Lansing, MI 48824 USA.
   [Nazarian, Javad] Childrens Natl Med Ctr, Washington, DC 20010 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3099
DI 10.1158/1538-7445.AM2014-3099
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200104
ER

PT J
AU Thrift, AP
   Berndt, SI
   Chan, AT
   Chang-Claude, J
   Slattery, ML
   Cotterchio, M
   Casey, G
   Potter, JD
   Newcomb, PA
   White, E
   Brenner, H
   Peters, U
   Campbell, PT
AF Thrift, Aaron P.
   Berndt, Sonja I.
   Chan, Andrew T.
   Chang-Claude, Jenny
   Slattery, Martha L.
   Cotterchio, Michelle
   Casey, Graham
   Potter, John D.
   Newcomb, Polly A.
   White, Emily
   Brenner, Hermann
   Peters, Ulrike
   Campbell, Peter T.
TI Obesity and risk of colorectal cancer: A Mendelian randomization study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Thrift, Aaron P.; Potter, John D.; Newcomb, Polly A.; White, Emily; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Berndt, Sonja I.] NCI, Bethesda, MD 20892 USA.
   [Chan, Andrew T.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Chan, Andrew T.] Harvard Univ, Sch Med, Boston, MA USA.
   [Chang-Claude, Jenny; Brenner, Hermann] German Canc Res Ctr, Heidelberg, Germany.
   [Slattery, Martha L.] Univ Utah Hlth Sci Ctr, Salt Lake City, UT USA.
   [Cotterchio, Michelle] Canc Care Ontario, Toronto, ON, Canada.
   [Casey, Graham] Univ So Calif, Los Angeles, CA USA.
   [Campbell, Peter T.] Amer Canc Soc, Atlanta, GA 30329 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2176
DI 10.1158/1538-7445.AM2014-2176
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902388
ER

PT J
AU Ting, Y
   Masuda, J
   Mizutani, A
   Chen, L
   Shigehiro, T
   Matsuda, S
   Kasai, T
   Kudoh, T
   Murakami, H
   Hendrix, MJC
   Strizzi, L
   Salomon, DS
   Fu, L
   Seno, M
AF Ting, Yan
   Masuda, Junko
   Mizutani, Akifumi
   Chen, Ling
   Shigehiro, Tsukasa
   Matsuda, Shuichi
   Kasai, Tomonari
   Kudoh, Takayuki
   Murakami, Hiroshi
   Hendrix, Mary J. C.
   Strizzi, Luigi
   Salomon, David S.
   Fu, Li
   Seno, Masaharu
TI Characterization of cancer stem-like cells derived from mouse induced
   pluripotent stem cells transformed by tumor-derived
   exosomes/microvesicles
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Ting, Yan; Masuda, Junko; Mizutani, Akifumi; Shigehiro, Tsukasa; Matsuda, Shuichi; Kasai, Tomonari; Kudoh, Takayuki; Murakami, Hiroshi; Seno, Masaharu] Okayama Univ, Okayama 7008530, Japan.
   [Chen, Ling; Fu, Li] Tianjin Cent Hosp Gynecol Obstet, Tianjin, Peoples R China.
   [Hendrix, Mary J. C.; Strizzi, Luigi] Northwestern Univ, Chicago, IL 60611 USA.
   [Salomon, David S.] NCI, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3016
DI 10.1158/1538-7445.AM2014-3016
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200023
ER

PT J
AU Tofilon, PJ
AF Tofilon, Philip J.
TI Translational control and tumor stem cell radioresponse
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tofilon, Philip J.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA SY42-01
DI 10.1158/1538-7445.AM2014-SY42-01
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205484
ER

PT J
AU Toriola, AT
   Dalidowitz, L
   Linehan, D
   Stolzenberg-Solomon, R
   Colditz, GA
AF Toriola, Adetunji T.
   Dalidowitz, Lara
   Linehan, David
   Stolzenberg-Solomon, Rachael
   Colditz, Graham A.
TI Diabetes and pancreatic cancer survival: a prospective cohort study
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Toriola, Adetunji T.; Dalidowitz, Lara; Linehan, David; Colditz, Graham A.] Washington Univ Sch Med, St Louis, MO USA.
   [Stolzenberg-Solomon, Rachael] NCI, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2169
DI 10.1158/1538-7445.AM2014-2169
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902381
ER

PT J
AU Tripathi, BK
   Qian, XL
   Mertins, P
   Wang, DR
   Papageorge, A
   Carr, S
   Lowy, DR
AF Tripathi, Brajendra K.
   Qian, Xiaolan
   Mertins, Philipp
   Wang, Dunrui
   Papageorge, Alex
   Carr, Steven
   Lowy, Douglas R.
TI CDK5 negatively regulates Rho by phosphorylating and activating the
   Rho-GAP and tumor suppressor functions of DLC1
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tripathi, Brajendra K.; Qian, Xiaolan; Papageorge, Alex; Lowy, Douglas R.] NIH, Bethesda, MD 20892 USA.
   [Mertins, Philipp; Carr, Steven] Broad Inst MIT & Harvard, Cambridge, MA USA.
   [Wang, Dunrui] W2MOTIF LLC, Res & Dev Div, San Diego, CA USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1574
DI 10.1158/1538-7445.AM2014-1574
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906901299
ER

PT J
AU Tsang, KY
   Boyerinas, B
   Jochems, C
   Rodell, T
   King, T
   Schlom, J
AF Tsang, Kwong Y.
   Boyerinas, Benjamin
   Jochems, Caroline
   Rodell, Tim
   King, Thomas
   Schlom, Jeffey
TI Yeast vector-encoding multiple MUC1 agonist epitopes (yeast-MUC1) can
   induce MUC1-specific T-cell immune responses
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Tsang, Kwong Y.; Boyerinas, Benjamin; Jochems, Caroline; Schlom, Jeffey] NCI, CCR, Bethesda, MD 20892 USA.
   [Rodell, Tim; King, Thomas] GlobeImmune Inc, Louisville, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2561
DI 10.1158/1538-7445.AM2014-2561
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903301
ER

PT J
AU Turan, S
AF Turan, Sevilay
TI Telomerase reverse transcriptase promoter alterations in human bladder
   cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Turan, Sevilay] NCI, NIH, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 565
DI 10.1158/1538-7445.AM2014-565
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905029
ER

PT J
AU Vijai, J
   Wang, ZM
   Berndt, SI
   Slager, SL
   Cerhan, JR
   Skibola, C
   Wang, SS
   Brooks-Wilson, AR
   de Sanjose, S
   Bracci, PM
   Melbye, M
   Glimelius, B
   Jackson, RD
   Cozen, W
   Becker, N
   Teras, LR
   Spinelli, JJ
   Turner, J
   Lan, Q
   Purdue, MP
   Bertrand, KA
   Offit, K
   Vineis, P
   Link, BK
   Giles, GG
   Zelenuich-Jacquotte, A
   Monnereau, A
   Ennas, MG
   Albanes, D
   Burdett, L
   Rothman, N
   Chanock, SJ
   Nieters, A
AF Vijai, Joseph
   Wang, Zhaoming
   Berndt, Sonja I.
   Slager, Susan L.
   Cerhan, James R.
   Skibola, Christine
   Wang, Sophia S.
   Brooks-Wilson, Angela R.
   de Sanjose, Silvia
   Bracci, Paige M.
   Melbye, Mads
   Glimelius, Bengt
   Jackson, Rebecca D.
   Cozen, Wendy
   Becker, Nikolaus
   Teras, Lauren R.
   Spinelli, John J.
   Turner, Jenny
   Lan, Qing
   Purdue, Mark P.
   Bertrand, Kimberly A.
   Offit, Kenneth
   Vineis, Paolo
   Link, Brian K.
   Giles, Graham G.
   Zelenuich-Jacquotte, Anne
   Monnereau, Alain
   Ennas, Maria Grazia
   Albanes, Demetrius
   Burdett, Laurie
   Rothman, Nathaniel
   Chanock, Stephen J.
   Nieters, Alexandra
TI A genome-wide association study suggests evidence of variants at 6p21.32
   associated with marginal zone lymphoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Vijai, Joseph] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA.
   [Wang, Zhaoming; Burdett, Laurie] NCI, Gaithersburg, MD USA.
   [Berndt, Sonja I.; Lan, Qing; Purdue, Mark P.; Albanes, Demetrius; Rothman, Nathaniel; Chanock, Stephen J.] NCI, Bethesda, MD 20892 USA.
   [Slager, Susan L.; Cerhan, James R.] Mayo Clin, Rochester, MN USA.
   [Skibola, Christine] Univ Alabama Birmingham, Birmingham, AL USA.
   [Wang, Sophia S.] City Hope Beckman Res Inst, Duarte, CA USA.
   [Brooks-Wilson, Angela R.] BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada.
   [de Sanjose, Silvia] IDIBELL, Inst Catala Oncol, Barcelona, Spain.
   [Bracci, Paige M.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Melbye, Mads] Statens Serum Inst, DK-2300 Copenhagen, Denmark.
   [Glimelius, Bengt] Karolinska Inst, Karolinska Univ Hosp Solna, Stockholm, Sweden.
   [Jackson, Rebecca D.] Ohio State Univ, Columbus, OH 43210 USA.
   [Cozen, Wendy] Univ So Calif, USC Keck Sch Med, Los Angeles, CA USA.
   [Becker, Nikolaus] German Canc Res Ctr, Heidelberg, Baden, Germany.
   [Teras, Lauren R.] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Spinelli, John J.] BC Canc Agcy, Vancouver, BC, Canada.
   [Turner, Jenny] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia.
   [Bertrand, Kimberly A.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
   [Offit, Kenneth] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.
   [Link, Brian K.] Carver Coll Med, Iowa City, IA USA.
   [Giles, Graham G.] Canc Council Victoria, Carlton, Vic, Australia.
   [Zelenuich-Jacquotte, Anne] NYU, Sch Med, New York, NY USA.
   [Monnereau, Alain] Ctr Res Epidemiol & Populat Hlth CESP, U1018, Villejuif, France.
   [Ennas, Maria Grazia] Univ Cagliari, Monserrato, Cagliari, France.
   [Nieters, Alexandra] Univ Med Ctr Freiburg, Freiburg, Hesse, Germany.
RI Brooks-Wilson, Angela/E-9399-2012; Purdue, Mark/C-9228-2016; de Sanjose
   Llongueras, Silvia/H-6339-2014
OI Brooks-Wilson, Angela/0000-0003-1009-6408; Purdue,
   Mark/0000-0003-1177-3108; 
NR 0
TC 1
Z9 1
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5071
DI 10.1158/1538-7445.AM2014-5071
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204026
ER

PT J
AU Vitale-Cross, LA
   Martin, D
   Rao, CV
   Kopelovich, L
   Gutkind, JS
AF Vitale-Cross, Lynn A.
   Martin, Daniel
   Rao, Chinthalapally V.
   Kopelovich, Levy
   Gutkind, J. Silvio
TI CP-31398 prevents the progression of oral squamous cell carcinomas from
   carcinogen-induced premalignant lesions
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Vitale-Cross, Lynn A.; Martin, Daniel; Gutkind, J. Silvio] NIDCR, NIH, OPCB, Bethesda, MD USA.
   [Rao, Chinthalapally V.] PC Stephenson Oklahoma Canc Ctr, Oklahoma City, OK USA.
   [Kopelovich, Levy] NCI, NIH, DCP, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 1260
DI 10.1158/1538-7445.AM2014-1260
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900498
ER

PT J
AU Wai, DH
   Ries, RE
   Considine, M
   Lee, DW
   Liu, SM
   O'Connor, NM
   Pepper, O
   Bista, R
   Aleem, E
   Azorsa, DO
   Davidsen, TM
   Farley, T
   Guidry-Auvil, J
   Farrar, JE
   Smith, MA
   Gerhard, DS
   Ochs, MF
   Mousses, S
   Meshinchi, S
   Arceci, RJ
AF Wai, Daniel H.
   Ries, Rhonda E.
   Considine, Michael
   Lee, David W.
   Liu, Sun-Mei
   O'Connor, Nicole M.
   Pepper, Oliver
   Bista, Ranjan
   Aleem, Eiman
   Azorsa, David O.
   Davidsen, Tanja M.
   Farley, Toni
   Guidry-Auvil, Jaime
   Farrar, Jason E.
   Smith, Malcolm A.
   Gerhard, Daniela S.
   Ochs, MIchael F.
   Mousses, Spyro
   Meshinchi, Soheil
   Arceci, Robert J.
TI Integrative genomic analyses on pediatric acute myeloid leukemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wai, Daniel H.; Lee, David W.; Bista, Ranjan; Aleem, Eiman; Azorsa, David O.; Arceci, Robert J.] Phoenix Childrens Hosp, Phoenix, AZ USA.
   [Ries, Rhonda E.; Meshinchi, Soheil] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Considine, Michael; Ochs, MIchael F.] Johns Hopkins Med, Baltimore, MD USA.
   [Liu, Sun-Mei; O'Connor, Nicole M.; Pepper, Oliver] Univ Arizona, Tempe, AZ USA.
   [Davidsen, Tanja M.; Guidry-Auvil, Jaime; Smith, Malcolm A.; Gerhard, Daniela S.] NIH, Bethesda, MD 20892 USA.
   [Farley, Toni; Mousses, Spyro] Translat Genom Res Inst, Phoenix, AZ USA.
   [Farrar, Jason E.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5583
DI 10.1158/1538-7445.AM2014-5583
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204497
ER

PT J
AU Walker, A
   Lopomo, P
   Babbitt, W
   Vigny, M
   Mackall, CL
   Orentas, RJ
AF Walker, Alec
   Lopomo, Paola
   Babbitt, William
   Vigny, Marc
   Mackall, Crystal L.
   Orentas, Rimas J.
TI Adoptive immunotherapy for pediatric solid tumors with CAR-T cells
   (chimeric antigen receptor bearing T cells) targeting ALK (anaplastic
   lymphoma kinase, CD246)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Walker, Alec; Lopomo, Paola; Babbitt, William; Mackall, Crystal L.; Orentas, Rimas J.] NCI, Bethesda, MD 20892 USA.
   [Vigny, Marc] UPMC, INSERM, Inst Fer Moulin, Paris, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2799
DI 10.1158/1538-7445.AM2014-2799
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906904057
ER

PT J
AU Wang, HS
   Burnett, T
   Kono, S
   Haiman, C
   Iwasaki, M
   Wilkens, L
   Loo, L
   Van Den Berg, D
   Kolonel, L
   Henderson, B
   Keku, T
   Sandler, R
   Signorello, L
   Blot, W
   Newcomb, P
   Pande, M
   Amos, C
   West, D
   Bezieau, S
   Berndt, S
   Zanke, B
   Hsu, L
   Lindor, N
   Haile, R
   Hopper, J
   Jenkins, M
   Gallinger, S
   Casey, G
   Stenzel, S
   Schumacher, F
   Peters, U
   Gruber, S
   Tsugane, S
   Stram, D
   Marchand, LL
AF Wang, Hansong
   Burnett, Terrilea
   Kono, Suminori
   Haiman, Christopher
   Iwasaki, Motoki
   Wilkens, Lynne
   Loo, Lenora
   Van Den Berg, David
   Kolonel, Laurence
   Henderson, Brian
   Keku, Temitope
   Sandler, Robert
   Signorello, Lisa
   Blot, William
   Newcomb, Polly
   Pande, Mala
   Amos, Christopher
   West, Dee
   Bezieau, Stephane
   Berndt, Sonja
   Zanke, Brent
   Hsu, Li
   Lindor, Noralane
   Haile, Robert
   Hopper, John
   Jenkins, Mark
   Gallinger, Steven
   Casey, Graham
   Stenzel, Stephanie
   Schumacher, Fredrick
   Peters, Ulrike
   Gruber, Stephen
   Tsugane, Shoichiro
   Stram, Dan
   Marchand, Loic L.
TI Transethnic genome-wide association study of colorectal cancer
   identifies a new susceptibility locus in VTI1A
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wang, Hansong; Burnett, Terrilea; Wilkens, Lynne; Loo, Lenora; Kolonel, Laurence; Marchand, Loic L.] UHCC, Honolulu, HI USA.
   [Kono, Suminori] Kyushu Univ, Fukuoka 812, Japan.
   [Haiman, Christopher; Van Den Berg, David; Henderson, Brian; Casey, Graham; Stenzel, Stephanie; Schumacher, Fredrick; Gruber, Stephen; Stram, Dan] USC, Los Angeles, CA USA.
   [Iwasaki, Motoki; Tsugane, Shoichiro] Natl Canc Ctr, Tokyo 104, Japan.
   [Keku, Temitope; Sandler, Robert] Univ N Carolina, Chapel Hill, NC USA.
   [Signorello, Lisa] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
   [Blot, William] Int Epidemiol Inst, Rockville, MD USA.
   [Newcomb, Polly; Hsu, Li; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Pande, Mala] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Amos, Christopher] Dartmouth Coll, Lebanon, NH 03756 USA.
   [West, Dee] Canc Prevent Inst Calif, Fremont, CA USA.
   [Bezieau, Stephane] CHU Nantes, F-44035 Nantes 01, France.
   [Berndt, Sonja] Natl Canc Ctr, Bethesda, MD USA.
   [Zanke, Brent] Univ Ottawa, Ottawa, ON, Canada.
   [Lindor, Noralane] Mayo Clin Arizona, Scottsdale, AZ USA.
   [Haile, Robert] Stanford Canc Inst, Stanford, CA USA.
   [Hopper, John; Jenkins, Mark] Univ Melbourne, Melbourne, Vic 3010, Australia.
   [Gallinger, Steven] Cancer Care Ontario, Toronto, ON, Canada.
RI Bezieau, stephane/G-5621-2015; Jenkins, Mark/P-7803-2015
OI Bezieau, stephane/0000-0003-0095-1319; Jenkins, Mark/0000-0002-8964-6160
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-282
DI 10.1158/1538-7445.AM2014-LB-282
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205314
ER

PT J
AU Wang, J
   He, PJ
   Gaida, MM
   Yang, SH
   Schetter, A
   Gaedcke, J
   Ghadimi, M
   Ried, T
   Yfantis, HG
   Lee, DH
   Weiss, JM
   Stauffer, J
   Hanna, N
   Alexander, HR
   Hussain, SP
AF Wang, Jian
   He, Peijun
   Gaida, Matthias M.
   Yang, Shouhui
   Schetter, Aaron
   Gaedcke, Jochen
   Ghadimi, Michael
   Ried, Thomas
   Yfantis, Harris G.
   Lee, Dong H.
   Weiss, Jonathan M.
   Stauffer, Jim
   Hanna, Nader
   Alexander, H. Richard
   Hussain, S. Perwez
TI Nitric oxide enhances tumor progression and disease aggressiveness in
   pancreatic cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wang, Jian; He, Peijun; Yang, Shouhui; Schetter, Aaron; Hussain, S. Perwez] NCI, Human Carcinogenesis Lab, Bethesda, MD 20892 USA.
   [Gaida, Matthias M.] NCI, Lab Immune Cell Biol, Bethesda, MD 20892 USA.
   [Gaedcke, Jochen; Ghadimi, Michael] Univ Med Ctr Gottingen, Dept Gen & Visceral Surg, Gottingen, Germany.
   [Ried, Thomas] NCI, Genet Branch, Bethesda, MD 20892 USA.
   [Yfantis, Harris G.; Lee, Dong H.] Baltimore Vet Affairs Med Ctr, Pathol & Lab Med, Baltimore, MD USA.
   [Weiss, Jonathan M.] NCI, Expt Immunol Lab, Bethesda, MD 20892 USA.
   [Stauffer, Jim] NCI, Mouse Canc Genet Program, Frederick, MD 21701 USA.
   [Hanna, Nader; Alexander, H. Richard] Univ Maryland, Sch Med, Div Surg Oncol, Baltimore, MD 21201 USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 926
DI 10.1158/1538-7445.AM2014-926
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905388
ER

PT J
AU Wang, J
   Figueroa, JD
   Wallstrom, G
   Sampson, J
   Garcia, EM
   Steel, J
   Park, J
   Anderson, KS
   Brinton, L
   Garcia-Closas, M
   Lissowska, J
   Sherman, ME
   Qiu, J
   LaBaer, J
AF Wang, Jie
   Figueroa, Jonine D.
   Wallstrom, Garrick
   Sampson, Joshua
   Garcia, Eliseo Mendoza
   Steel, Jason
   Park, Jin
   Anderson, Karen S.
   Brinton, Louise
   Garcia-Closas, Montserrat
   Lissowska, Jolanta
   Sherman, Mark E.
   Qiu, Ji
   LaBaer, Joshua
TI Autoantibody biomarker discovery in basal-like breast cancer using
   nucleic acid programmable protein array
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wang, Jie; Wallstrom, Garrick; Garcia, Eliseo Mendoza; Steel, Jason; Park, Jin; Anderson, Karen S.; Qiu, Ji; LaBaer, Joshua] Arizona State Univ, Biodesign Inst, Tempe, AZ USA.
   [Figueroa, Jonine D.; Sampson, Joshua; Brinton, Louise] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
   [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW3 6JB, England.
   [Lissowska, Jolanta] M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland.
   [Sherman, Mark E.] NCI, Canc Prevent Div, Rockville, MD USA.
RI Brinton, Louise/G-7486-2015
OI Brinton, Louise/0000-0003-3853-8562
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 874
DI 10.1158/1538-7445.AM2014-874
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905332
ER

PT J
AU Watson, IR
   Wu, CJ
   Gershenwald, JE
   Chin, L
AF Watson, Ian R.
   Wu, Chang-Jiun
   Gershenwald, Jeffrey E.
   Chin, Lynda
CA Melanoma Anal Working Grp
   Canc Genome Anal Res Network
TI Comprehensive genomic characterization of cutaneous melanoma
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Watson, Ian R.; Wu, Chang-Jiun; Gershenwald, Jeffrey E.; Chin, Lynda] MD Anderson, Houston, TX USA.
   [Melanoma Anal Working Grp; Canc Genome Anal Res Network] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA LB-315
DI 10.1158/1538-7445.AM2014-LB-315
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205350
ER

PT J
AU Wayne, AS
   Shah, NN
   Bhojwani, D
   Silverman, LB
   Whitlock, JA
   Stetler-Stevenson, M
   Kreitman, RJ
   Goswami, T
   Ibrahim, R
   Pastan, I
AF Wayne, Alan S.
   Shah, Nirali N.
   Bhojwani, Deepa
   Silverman, Lewis B.
   Whitlock, James A.
   Stetler-Stevenson, Maryalice
   Kreitman, Robert J.
   Goswami, Trishna
   Ibrahim, Ramy
   Pastan, Ira
TI Pediatric phase 1 trial of moxetumomab pasudotox: Activity in
   chemotherapy refractory acute lymphoblastic leukemia (ALL)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wayne, Alan S.] Univ So Calif, Childrens Hosp Los Angeles, Los Angeles, CA USA.
   [Shah, Nirali N.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Bhojwani, Deepa] St Jude Childrens Res Hosp, Oncol, Memphis, TN 38105 USA.
   [Silverman, Lewis B.] Boston Childrens Hosp, Dana Farber Canc Inst, Pediat Oncol, Boston, MA USA.
   [Whitlock, James A.] Univ Toronto, Hosp Sick Children, Dept Pediat, Hematol Oncol, Toronto, ON M5G 1X8, Canada.
   [Stetler-Stevenson, Maryalice] NCI, Pathol Lab, CCR, NIH, Bethesda, MD 20892 USA.
   [Kreitman, Robert J.; Pastan, Ira] NCI, Mol Biol Lab, CCR, NIH, Bethesda, MD 20892 USA.
   [Goswami, Trishna; Ibrahim, Ramy] MedImmune, Gaithersburg, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA CT230
DI 10.1158/1538-7445.AM2014-CT230
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910205057
ER

PT J
AU Wei, JS
   Patidar, R
   Shern, J
   Zhang, SL
   Pugh, T
   Diskin, SJ
   Sindiri, S
   Song, YK
   Liao, HL
   Wen, XY
   Wang, JJ
   Skapek, SX
   Anderson, JR
   Barr, FG
   Seeger, RC
   Maris, JM
   Hawkins, DS
   Khan, J
AF Wei, Jun S.
   Patidar, Rajesh
   Shern, John
   Zhang, Shile
   Pugh, Trevor
   Diskin, Sharon J.
   Sindiri, Sivasish
   Song, Young K.
   Liao, Hongling
   Wen, Xinyu
   Wang, Jianjun
   Skapek, Stephen X.
   Anderson, James R.
   Barr, Frederic G.
   Seeger, Robert C.
   Maris, John M.
   Hawkins, Douglas S.
   Khan, Javed
TI Systematic identification of germline mutations in rhabdomyosarcoma and
   neuroblastoma using massively paralleled sequencing
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wei, Jun S.; Patidar, Rajesh; Shern, John; Zhang, Shile; Sindiri, Sivasish; Song, Young K.; Liao, Hongling; Wen, Xinyu; Wang, Jianjun; Barr, Frederic G.; Khan, Javed] NCI, Bethesda, MD 20892 USA.
   [Pugh, Trevor] Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Diskin, Sharon J.; Maris, John M.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Skapek, Stephen X.] UT Southwestern Med Ctr, Dallas, TX USA.
   [Anderson, James R.] Univ Nebraska Med Ctr, Omaha, NE USA.
   [Seeger, Robert C.] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
   [Hawkins, Douglas S.] Seattle Childrens Hosp, Seattle, WA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5081
DI 10.1158/1538-7445.AM2014-5081
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204036
ER

PT J
AU Weinstein, JN
   Peng, B
   Reinhold, WC
   Pommier, Y
   Lorenzi, PL
AF Weinstein, John N.
   Peng, Bo
   Reinhold, William C.
   Pommier, Yves
   Lorenzi, Philip L.
TI Drug mechanisms of action: Triangulating with cultured cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Weinstein, John N.; Peng, Bo; Lorenzi, Philip L.] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
   [Reinhold, William C.; Pommier, Yves] NCI, Mol Pharmacol Lab, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3788
DI 10.1158/1538-7445.AM2014-3788
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201278
ER

PT J
AU Weinstein, JN
   Kim, J
   Creighton, CJ
   Akbani, R
   Hoadley, KA
   Kim, WY
   Morgan, MB
   Hinoue, T
   Cherniack, A
   Su, X
   Mungall, AJ
   Ryan, MC
   Rosenberg, JE
   Bajorin, DF
   Czerniak, B
   Hansel, D
   Reuter, VE
   Robinson, BD
   Al-Ahmadie, HA
   Damrauer, JS
   Zhang, W
   Liu, Y
   Gordenin, D
   Stuart, JM
   Schultz, N
   Robertson, G
   Kucherlapati, R
   Laird, PW
   Mills, GB
   Kwiatkowski, DJ
   Lerner, SP
AF Weinstein, John N.
   Kim, Jaegil
   Creighton, Chad J.
   Akbani, Rehan
   Hoadley, Katherine A.
   Kim, William Y.
   Morgan, Margaret B.
   Hinoue, Toshinori
   Cherniack, Andrew
   Su, Xiaoping
   Mungall, Andrew J.
   Ryan, Michael C.
   Rosenberg, Jonathan E.
   Bajorin, Dean F.
   Czerniak, Bogdan
   Hansel, Donna
   Reuter, Victor E.
   Robinson, Brian D.
   Al-Ahmadie, Hikmat A.
   Damrauer, Jeffrey S.
   Zhang, Wei
   Liu, Yuexin
   Gordenin, Dmitry
   Stuart, Joshua M.
   Schultz, Nikolaus
   Robertson, Gordon
   Kucherlapati, Raju
   Laird, Peter W.
   Mills, Gordon B.
   Kwiatkowski, David J.
   Lerner, Seth P.
CA TCGAs Bladder Canc Working Grp
TI Comprehensive characterization of urothelial bladder cancer: a TCGA
   Project update
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Weinstein, John N.; Akbani, Rehan; Su, Xiaoping] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
   [Kim, Jaegil; Cherniack, Andrew] MIT, Broad Inst, Cambridge, MA 02139 USA.
   [Kim, Jaegil; Cherniack, Andrew] Harvard Univ, Cambridge, MA 02138 USA.
   [Creighton, Chad J.] Baylor Coll Med, Human Genome Sequencing Ctr, Dan L Duncan Canc Ctr, Houston, TX 77030 USA.
   [Hoadley, Katherine A.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
   [Kim, William Y.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
   [Morgan, Margaret B.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
   [Hinoue, Toshinori; Laird, Peter W.] Univ So Calif, Epigenome Ctr, Los Angeles, CA USA.
   [Mungall, Andrew J.; Robertson, Gordon] Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada.
   [Ryan, Michael C.] In Silico Solut, Fairfax, VA USA.
   [Rosenberg, Jonathan E.; Bajorin, Dean F.; Reuter, Victor E.; Al-Ahmadie, Hikmat A.; Schultz, Nikolaus] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Czerniak, Bogdan; Zhang, Wei; Liu, Yuexin] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Hansel, Donna] UCSD Dept Pathol, San Diego, CA USA.
   [Robinson, Brian D.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA.
   [Damrauer, Jeffrey S.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
   [Gordenin, Dmitry] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
   [Stuart, Joshua M.] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA.
   [Kucherlapati, Raju] Harvard Univ, Sch Med, Partners HealthCare Ctr Genet & Genom, Boston, MA USA.
   [Mills, Gordon B.] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA.
   [Kwiatkowski, David J.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Lerner, Seth P.] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 987
DI 10.1158/1538-7445.AM2014-987
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905454
ER

PT J
AU Weinstein, SJ
   Mondul, A
   Mannisto, S
   Albanes, D
AF Weinstein, Stephanie J.
   Mondul, Alison
   Mannisto, Satu
   Albanes, Demetrius
TI Circulating 25-hydroxyvitamin D and prostate cancer survival
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Weinstein, Stephanie J.; Mondul, Alison; Albanes, Demetrius] NCI, Bethesda, MD 20892 USA.
   [Mannisto, Satu] Natl Inst Hlth & Welf, Helsinki, Finland.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5069
DI 10.1158/1538-7445.AM2014-5069
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204024
ER

PT J
AU Whiting, AL
   Mitala, JJ
   Headley, KM
   Reilly, J
   Morrison, BL
   Murray, KA
   Bernal, F
AF Whiting, Amanda L.
   Mitala, Joe J.
   Headley, Kathryn M.
   Reilly, Joe
   Morrison, Bethanie L.
   Murray, Kevin A.
   Bernal, Federico
TI Covalent capture of protein binding partners using an azide-tagged,
   photo-reactive stapled alpha helical p53 peptide
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Whiting, Amanda L.; Mitala, Joe J.; Headley, Kathryn M.; Reilly, Joe; Morrison, Bethanie L.; Murray, Kevin A.; Bernal, Federico] NIH, Lymphoid Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3234
DI 10.1158/1538-7445.AM2014-3234
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200237
ER

PT J
AU Williams, KA
   Bupp, S
   Patel, S
   Andreas, J
   Zhang, SY
   Molinolo, A
   Gutkind, S
   Crawford, N
AF Williams, Kendra A.
   Bupp, Sujata
   Patel, Shashank
   Andreas, Jonathan
   Zhang, Suiyuan
   Molinolo, Alfredo
   Gutkind, Silvio
   Crawford, Nigel
TI Germline variation modulates susceptibility to aggressive disease
   development in a mouse model of prostate tumorigenesis
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Williams, Kendra A.; Bupp, Sujata; Patel, Shashank; Andreas, Jonathan; Crawford, Nigel] NHGRI, Genet & Mol Biol Branch, NIH, Bethesda, MD 20892 USA.
   [Zhang, Suiyuan] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA.
   [Molinolo, Alfredo; Gutkind, Silvio] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4952
DI 10.1158/1538-7445.AM2014-4952
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203414
ER

PT J
AU Wilsker, DF
   Marrero, AM
   Hollingshead, M
   Lawrence, SM
   Chen, A
   Kummar, S
   Covey, JM
   Parchment, RE
   Kinders, RJ
   Tomaszewski, JE
   Doroshow, JH
AF Wilsker, Deborah F.
   Marrero, Allison M.
   Hollingshead, Melinda
   Lawrence, Scott M.
   Chen, Alice
   Kummar, Shivaani
   Covey, Joseph M.
   Parchment, Ralph E.
   Kinders, Robert J.
   Tomaszewski, Joseph E.
   Doroshow, James H.
TI Pre-clinical investigation of the wee1 inhibitor MK-1775 using
   pharmacodynamic and mechanistic markers in diverse cancer models in vivo
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wilsker, Deborah F.; Marrero, Allison M.; Lawrence, Scott M.; Parchment, Ralph E.; Kinders, Robert J.] Leidos Biomed Res Inc, Lab Human Toxicol & Pharmacol, Applied Dev Directorate, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [Hollingshead, Melinda] Frederick Natl Lab Canc Res, Biol Testing Branch, Frederick, MD USA.
   [Chen, Alice; Kummar, Shivaani; Tomaszewski, Joseph E.; Doroshow, James H.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Covey, Joseph M.] NCI, Toxicol & Pharmacol Branch, Dev Therapeut Program, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4689
DI 10.1158/1538-7445.AM2014-4689
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203162
ER

PT J
AU Wnorowski, A
   Paul, RK
   Jimenez, L
   Toll, L
   Kotb, A
   Bernier, M
   Wainer, IW
AF Wnorowski, Artur
   Paul, Rajib K.
   Jimenez, Lucita
   Toll, Lawrence
   Kotb, Abdelmohsen
   Bernier, Michel
   Wainer, Irving W.
TI (R,R ')-4 '-methoxy-1-naphtylfenoterol inhibits pro-survival signaling,
   proliferation and motility of select human melanoma cell lines
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wnorowski, Artur] Med Univ Lublin, Lublin, Poland.
   [Paul, Rajib K.; Kotb, Abdelmohsen; Bernier, Michel; Wainer, Irving W.] NIA, Baltimore, MD 21224 USA.
   [Jimenez, Lucita] SRI Int, Menlo Pk, CA 94025 USA.
   [Toll, Lawrence] Torrey Pines Inst Mol Studies, Port St Lucie, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3680
DI 10.1158/1538-7445.AM2014-3680
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201172
ER

PT J
AU Wrzeszczynski, KO
   Polley, EC
   Hose, C
   Monks, A
   Teicher, BA
AF Wrzeszczynski, Kazimierz O.
   Polley, Eric C.
   Hose, Curtis
   Monks, Anne
   Teicher, Beverly A.
TI Identification and analysis of gene fusion and splice variant events in
   the NCI sarcoma cell line panel
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wrzeszczynski, Kazimierz O.; Polley, Eric C.; Teicher, Beverly A.] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA.
   [Hose, Curtis; Monks, Anne] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2361
DI 10.1158/1538-7445.AM2014-2361
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906903085
ER

PT J
AU Wu, C
   Wang, ZM
   Song, X
   Feng, XS
   Abnet, CC
   He, J
   Hu, N
   Zuo, XB
   Tan, W
   Zhang, XJ
   Freedman, ND
   Goldstein, AM
   Lin, DX
   Taylor, PR
   Wang, LD
   Chanock, SJ
AF Wu, Chen
   Wang, Zhaoming
   Song, Xin
   Feng, Xiao-Shan
   Abnet, Christian C.
   He, Jie
   Hu, Nan
   Zuo, Xian-Bo
   Tan, Wen
   Zhang, Xue-Jun
   Freedman, Neal D.
   Goldstein, Alisa M.
   Lin, Dongxin
   Taylor, Philip R.
   Wang, Li-Dong
   Chanock, Stephen J.
TI Joint analysis of three genome-wide association studies of esophageal
   squamous cell carcinoma in Chinese populations reveals new
   susceptibility loci
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wu, Chen; Tan, Wen; Lin, Dongxin] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China.
   [Wu, Chen; He, Jie; Tan, Wen; Lin, Dongxin] Peking Union Med Coll, Beijing 100021, Peoples R China.
   [Wang, Zhaoming] Leidos Biomed Res Inc, Canc Genom Res Lab, Div Canc Epidemiol & Genet, Gaithersburg, MD USA.
   [Song, Xin; Wang, Li-Dong] Xinxiang Med Univ, Dept Pathol, Basic Med Coll, Canc Res Ctr, Xinxiang, Henan, Peoples R China.
   [Feng, Xiao-Shan] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol Pathol Clin Lab & Resp Med, Luoyang, Henan, Peoples R China.
   [Abnet, Christian C.; Hu, Nan; Freedman, Neal D.; Goldstein, Alisa M.; Taylor, Philip R.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [He, Jie] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100730, Peoples R China.
   [Zuo, Xian-Bo; Zhang, Xue-Jun] Anhui Med Univ, Key Lab Dermatol, Hefei, Anhui, Peoples R China.
RI Abnet, Christian/C-4111-2015
OI Abnet, Christian/0000-0002-3008-7843
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2204
DI 10.1158/1538-7445.AM2014-2204
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902415
ER

PT J
AU Wu, CP
   Sim, HM
   Ambudkar, SV
AF Wu, Chung-Pu
   Sim, Hong-May
   Ambudkar, Suresh V.
TI Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1
   inhibitors, BI 2536, volasertib and GSK641364
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wu, Chung-Pu] Chang Gung Univ, Kwei Shan, Taiwan.
   [Sim, Hong-May; Ambudkar, Suresh V.] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 766
DI 10.1158/1538-7445.AM2014-766
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905226
ER

PT J
AU Wu, YZ
   Doroshow, JH
AF Wu, Yongzhong
   Doroshow, James H.
TI IL-4/IL-13 induce Duox2/DuoxA2 expression and reactive oxygen production
   in human pancreatic and colon cancer cells
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Wu, Yongzhong; Doroshow, James H.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5358
DI 10.1158/1538-7445.AM2014-5358
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204277
ER

PT J
AU Xiao, CL
   Zook, J
   Trask, S
   Sherry, S
AF Xiao, Chunlin
   Zook, Justin
   Trask, Shane
   Sherry, Stephen
CA Genome-In-A-Bottle Consortium
TI GIAB: Genome reference material development resources for clinical
   sequencing
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Xiao, Chunlin; Trask, Shane; Sherry, Stephen] NIH, Bethesda, MD 20892 USA.
   [Zook, Justin] NIST, Gaithersburg, MD 20899 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5328
DI 10.1158/1538-7445.AM2014-5328
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204248
ER

PT J
AU Xiao, ZX
   Willette-Brown, J
   Hu, YL
   Xi, SC
AF Xiao, Zuoxiang
   Willette-Brown, Jami
   Hu, Yinling
   Xi, Sichuan
TI TNFR1 is indispensable in the development of spontaneous lung squamous
   cell carcinomas
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Xiao, Zuoxiang; Willette-Brown, Jami; Hu, Yinling] NCI, Frederick, MD 21701 USA.
   [Xi, Sichuan] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 603
DI 10.1158/1538-7445.AM2014-603
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905065
ER

PT J
AU Yan, S
   Thiele, C
AF Yan, Shuang
   Thiele, Carol
TI Inhibition of STAT3 sensitizes neuroblastoma xenografts cells to
   Etoposide
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yan, Shuang; Thiele, Carol] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4736
DI 10.1158/1538-7445.AM2014-4736
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203209
ER

PT J
AU Yang, CZ
   Pacak, K
   Zhuang, ZP
AF Yang, Chunzhang
   Pacak, Karel
   Zhuang, Zhengping
TI Somatic HIF2A mutations identified in a new syndrome with multiple
   paragangliomas and somatostatinomas associated with polycythemia
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yang, Chunzhang; Zhuang, Zhengping] NINDS, Bethesda, MD 20892 USA.
   [Pacak, Karel] NICHD, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4399
DI 10.1158/1538-7445.AM2014-4399
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202375
ER

PT J
AU Yang, HP
   Cook, LS
   Weiderpass, E
   Adami, HO
   Anderson, KE
   Cai, H
   Cerhan, JR
   Clendenen, T
   Felix, AS
   Friedenreich, C
   Garcia-Closas, M
   Goodman, MT
   Liang, XL
   Lissowska, J
   Lu, LG
   Magliocco, AM
   McCann, SE
   Moysich, KB
   Olson, SH
   Pike, MC
   Polidoro, S
   Ricceri, F
   Risch, H
   Sacerdote, C
   Setiawan, VW
   Shu, XO
   Spurdle, AB
   Trabert, B
   Webb, PM
   Wentzensen, N
   Xiang, YB
   Xu, YM
   Yu, H
   Zeleniuch-Jacquotte, A
   Brinton, LA
AF Yang, Hannah P.
   Cook, Linda S.
   Weiderpass, Elisabete
   Adami, Hans-Olov
   Anderson, Kristin E.
   Cai, Hui
   Cerhan, James R.
   Clendenen, Tess
   Felix, Ashley S.
   Friedenreich, Christine
   Garcia-Closas, Montserrat
   Goodman, Marc T.
   Liang, Xiaolin
   Lissowska, Jolanta
   Lu, Lingeng
   Magliocco, Anthony M.
   McCann, Susan E.
   Moysich, Kristen B.
   Olson, Sara H.
   Pike, Malcolm C.
   Polidoro, Silvia
   Ricceri, Fulvio
   Risch, Harvey
   Sacerdote, Carlotta
   Setiawan, V. Wendy
   Shu, Xiao O.
   Spurdle, Amanda B.
   Trabert, Britton
   Webb, Penelope M.
   Wentzensen, Nicolas
   Xiang, Yong-Bing
   Xu, Youming
   Yu, Herbert
   Zeleniuch-Jacquotte, Anne
   Brinton, Louise A.
TI Infertility and risk of incident endometrial carcinoma: a pooled
   analysis from the Epidemiology of Endometrial Cancer Consortium
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yang, Hannah P.; Felix, Ashley S.; Trabert, Britton; Wentzensen, Nicolas; Brinton, Louise A.] NCI, Bethesda, MD 20892 USA.
   [Cook, Linda S.] Univ New Mexico, Albuquerque, NM 87131 USA.
   [Weiderpass, Elisabete; Adami, Hans-Olov] Karolinska Inst, Stockholm, Sweden.
   [Anderson, Kristin E.] Univ Minnesota, Minneapolis, MN USA.
   [Cai, Hui; Shu, Xiao O.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Cerhan, James R.] Mayo Clin, Rochester, MN USA.
   [Clendenen, Tess; Zeleniuch-Jacquotte, Anne] NYU, Sch Med, New York, NY USA.
   [Friedenreich, Christine] Alberta Hlth Serv, Calgary, AB, Canada.
   [Garcia-Closas, Montserrat] Inst Canc Res, Sutton, Surrey, England.
   [Goodman, Marc T.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   [Liang, Xiaolin; Olson, Sara H.; Pike, Malcolm C.; Xu, Youming] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Lissowska, Jolanta] M Sklodowska Curie Mem Canc Ctr & Inst Oncol, Warsaw, Poland.
   [Lu, Lingeng; Risch, Harvey] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
   [Magliocco, Anthony M.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
   [McCann, Susan E.; Moysich, Kristen B.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
   [Polidoro, Silvia; Ricceri, Fulvio] Human Genet Fdn, Turin, Italy.
   [Sacerdote, Carlotta] Univ Turin, Turin, Italy.
   [Sacerdote, Carlotta] Ctr Canc Prevent, Turin, Italy.
   [Setiawan, V. Wendy] Univ So Calif, Los Angeles, CA USA.
   [Spurdle, Amanda B.; Webb, Penelope M.] QIMR Berghofer Med Res Inst, Herston, Qld, Australia.
   [Xiang, Yong-Bing] Shanghai Canc Inst, Shanghai, Peoples R China.
   [Yu, Herbert] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
RI Brinton, Louise/G-7486-2015; Trabert, Britton/F-8051-2015; Weiderpass,
   Elisabete/M-4029-2016; 
OI Brinton, Louise/0000-0003-3853-8562; Weiderpass,
   Elisabete/0000-0003-2237-0128; Zeleniuch-Jacquotte,
   Anne/0000-0001-9350-1303
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2167
DI 10.1158/1538-7445.AM2014-2167
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902379
ER

PT J
AU Yang, HH
   Lee, MP
AF Yang, Howard H.
   Lee, Maxwell P.
TI Robust feature selection and gene committee predictor for breast cancer
   patient survival prediction
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yang, Howard H.; Lee, Maxwell P.] NCI, High Dimens Data Anal Grp, BRL, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4125
DI 10.1158/1538-7445.AM2014-4125
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202107
ER

PT J
AU Yang, SH
   He, PJ
   Wang, J
   Schetter, A
   Funamizu, N
   Yanaga, K
   Gaedcke, J
   Ghadimi, BM
   Gaida, MM
   Ried, T
   Hanna, N
   Alexander, HR
   Hussain, SP
AF Yang, Shouhui
   He, Peijun
   Wang, Jian
   Schetter, Aaron
   Funamizu, Naotake
   Yanaga, Katsuhiko
   Gaedcke, Jochen
   Ghadimi, B. Michael
   Gaida, Matthias M.
   Ried, Thomas
   Hanna, Nader
   Alexander, H. Richard
   Hussain, S. Perwez
TI Macrophage migration inhibitory factor (MIF) and miR-301b interactively
   enhance disease aggressiveness by targeting NR3C2 in human pancreatic
   cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yang, Shouhui; He, Peijun; Wang, Jian; Hussain, S. Perwez] NCI, Pancreat Canc Unit, Human Carcinogenesis Lab, CCR, Bethesda, MD 20892 USA.
   [Schetter, Aaron] NCI, Human Carcinogenesis Lab, CCR, Bethesda, MD 20892 USA.
   [Funamizu, Naotake; Yanaga, Katsuhiko] Jikei Univ, Sch Med, Dept Surg, Tokyo, Japan.
   [Gaedcke, Jochen; Ghadimi, B. Michael] Univ Med, Dept Gen & Visceral Surg, Gottingen, Germany.
   [Gaida, Matthias M.] NCI, Lab Immune Cell Biol, CCR, Bethesda, MD 20892 USA.
   [Ried, Thomas] NCI, Genet Branch, CCR, Bethesda, MD 20892 USA.
   [Hanna, Nader; Alexander, H. Richard] Univ Maryland, Sch Med, Div Surg Oncol, Baltimore, MD 21201 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4363
DI 10.1158/1538-7445.AM2014-4363
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202339
ER

PT J
AU Yang, XP
   Cheng, H
   Si, H
   Saleh, A
   Maiorov, EG
   Coupar, J
   Keskin, O
   Gursoy, A
   Nussinov, R
   Ferris, RL
   Yarbrough, WG
   Prince, ME
   Carey, TE
   Van Waes, C
   Chen, Z
AF Yang, Xinping
   Cheng, Hui
   Si, Han
   Saleh, Anthony
   Maiorov, Emine Guven
   Coupar, Jamie
   Keskin, Ozlem
   Gursoy, Attila
   Nussinov, Ruth
   Ferris, Robert L.
   Yarbrough, Wendell G.
   Prince, Mark E.
   Carey, Thomas E.
   Van Waes, Carter
   Chen, Zhong
TI Genome-wide RNA and DNA high throughput sequencing reveals
   proinflammatory and death gene signatures in head and neck squamous cell
   carcinoma lines with different HPV status
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yang, Xinping; Cheng, Hui; Saleh, Anthony; Coupar, Jamie; Van Waes, Carter; Chen, Zhong] NIDCD, NIH, Bethesda, MD USA.
   [Si, Han] NEI, NIH, Bethesda, MD 20892 USA.
   [Maiorov, Emine Guven; Keskin, Ozlem; Gursoy, Attila; Nussinov, Ruth] Koc Univ, Coll Engn, Ctr Computat Biol & Bioinformat, Istanbul, Turkey.
   [Ferris, Robert L.] Univ Pittsburgh, Dept Otolaryngol, Div Head & Neck Surg, Inst Canc, Pittsburgh, PA 15260 USA.
   [Ferris, Robert L.] Univ Pittsburgh, Dept Radiat Oncol, Div Head & Neck Surg, Inst Canc, Pittsburgh, PA USA.
   [Ferris, Robert L.] Univ Pittsburgh, Dept Immunol, Div Head & Neck Surg, Inst Canc, Pittsburgh, PA USA.
   [Yarbrough, Wendell G.] Yale Univ, Sch Med, Dept Surg,Yale Canc Ctr, Div Otolaryngol,Mol Virol Res Program,Smilow Canc, New Haven, CT 06510 USA.
   [Prince, Mark E.; Carey, Thomas E.] Univ Michigan, Rackham Grad Sch, Program Biomed Sci, Canc Biol Program, Ann Arbor, MI 48109 USA.
RI Gursoy, Attila/E-9565-2015
OI Gursoy, Attila/0000-0002-2297-2113
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3435
DI 10.1158/1538-7445.AM2014-3435
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200434
ER

PT J
AU Yoshimura, T
   Howard, OMZ
   Ito, T
   Kuwabara, M
   Matsukawa, A
   Chen, KQ
   Liu, Y
   Liu, MY
   Wang, JM
AF Yoshimura, Teizo
   Howard, O. M. Zack
   Ito, Toshihiro
   Kuwabara, Masaki
   Matsukawa, Akihiro
   Chen, Keqiang
   Liu, Ying
   Liu, Mingyong
   Wang, Ji Ming
TI Metastasis of 4T1 murine breast cancer cells to the lung is dependent on
   the chemokine CCL2/MCP-1 produced by stromal cells in the primary tumor
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yoshimura, Teizo; Howard, O. M. Zack; Chen, Keqiang; Liu, Ying; Liu, Mingyong; Wang, Ji Ming] NCI, Frederick, MD 21701 USA.
   [Ito, Toshihiro; Kuwabara, Masaki; Matsukawa, Akihiro] Okayama Univ, Okayama 7008530, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3585
DI 10.1158/1538-7445.AM2014-3585
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201081
ER

PT J
AU Yu, YL
AF Yu, Yanlin
TI PTEN phosphatase inhibits metastasis through negatively affecting
   Entpd5/IGF1R pathway
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Yu, Yanlin] NCI, CCR, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 136
DI 10.1158/1538-7445.AM2014-136
PG 1
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906900135
ER

PT J
AU Zhang, JL
   Cheng, H
   Yang, XP
   Maiorov, EG
   Keskin, O
   Gursoy, A
   Nussinov, R
   Chen, Z
   Van Waes, C
AF Zhang, Jialing
   Cheng, Hui
   Yang, Xinping
   Maiorov, Emine Guven
   Keskin, Ozlem
   Gursoy, Attila
   Nussinov, Ruth
   Chen, Zhong
   Van Waes, Carter
TI Alternative NF-kappa B pathway activation enhanced by deficient TRAF3 in
   human papillomavirus (HPV)-associated head and neck cancer
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhang, Jialing; Cheng, Hui; Yang, Xinping; Chen, Zhong; Van Waes, Carter] NIDCD, NIH, Bethesda, MD USA.
   [Maiorov, Emine Guven; Keskin, Ozlem; Gursoy, Attila] Ctr Computat Biol & Bioinformat, Istanbul, Turkey.
   [Nussinov, Ruth] NCI, Canc & Inflammat Program, Leidos Biomed Res Inc, NIH, Frederick, MD 21701 USA.
RI Gursoy, Attila/E-9565-2015
OI Gursoy, Attila/0000-0002-2297-2113
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3170
DI 10.1158/1538-7445.AM2014-3170
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200174
ER

PT J
AU Zhang, TW
   Xu, M
   Chow, D
   Sereduk, C
   Trent, JM
   Yin, HW
   Brown, KM
AF Zhang, Tongwu
   Xu, Mai
   Chow, Donald
   Sereduk, Chris
   Trent, Jeffrey M.
   Yin, Hongwei
   Brown, Kevin M.
TI Identification of gene regulatory networks mediating melanoma cell
   resistance to temozolomide
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhang, Tongwu; Xu, Mai; Brown, Kevin M.] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Gaithersburg, MD USA.
   [Chow, Donald; Sereduk, Chris; Trent, Jeffrey M.; Yin, Hongwei] Translat Genom Res Inst TGen, Canc & Cell Biol Div, Scottsdale, AZ USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3776
DI 10.1158/1538-7445.AM2014-3776
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910201266
ER

PT J
AU Zhao, E
   Maj, T
   Kryczek, I
   Zhao, LL
   Wei, S
   Wan, SS
   Crespo, J
   Szeliga, W
   Vatan, L
   Wu, K
   Chinnaiyan, AM
   Welling, TH
   Marquez, VE
   Kotarski, J
   Zhang, Y
   Liu, R
   Tao, KX
   Wang, GB
   Zou, WP
AF Zhao, Ende
   Maj, Tomasz
   Kryczek, Ilona
   Zhao, Lili
   Wei, Shuang
   Wan, Shanshan
   Crespo, Joel
   Szeliga, Wojciech
   Vatan, Linda
   Wu, Ke
   Chinnaiyan, Arul M.
   Welling, Theodore H.
   Marquez, Victor E.
   Kotarski, Jan
   Zhang, Yi
   Liu, Rebecca
   Tao, Kaixiong
   Wang, Guobin
   Zou, Weiping
TI EZH2 marks polyfunctional memory T cells and controls tumor immunity
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhao, Ende; Wu, Ke; Tao, Kaixiong; Wang, Guobin] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan 430074, Peoples R China.
   [Maj, Tomasz; Kryczek, Ilona; Zhao, Lili; Wei, Shuang; Wan, Shanshan; Crespo, Joel; Szeliga, Wojciech; Vatan, Linda; Chinnaiyan, Arul M.; Welling, Theodore H.; Zhang, Yi; Liu, Rebecca; Zou, Weiping] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Marquez, Victor E.] NCI Frederick, Frederick, MD USA.
   [Kotarski, Jan] Med Univ Lublin, Lublin, Poland.
RI Zhao, Ende/B-9851-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4078
DI 10.1158/1538-7445.AM2014-4078
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202060
ER

PT J
AU Zhou, CK
   Pfeiffer, RM
   Cleary, SD
   Hoffman, HJ
   Levine, PH
   Chu, LW
   Hsing, AW
   Cook, MB
AF Zhou, Cindy K.
   Pfeiffer, Ruth M.
   Cleary, Sean D.
   Hoffman, Heather J.
   Levine, Paul H.
   Chu, Lisa W.
   Hsing, Ann W.
   Cook, Michael B.
TI Male pattern baldness increases the risk of aggressive prostate cancer:
   A prospective analysis of the Prostate, Lung, Colorectal and Ovarian
   (PLCO) Cancer Screening Trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhou, Cindy K.] George Washington Univ, NCI, Bethesda, MD USA.
   [Pfeiffer, Ruth M.; Cook, Michael B.] NCI, Bethesda, MD 20892 USA.
   [Cleary, Sean D.; Hoffman, Heather J.; Levine, Paul H.] George Washington Univ, Washington, DC USA.
   [Chu, Lisa W.; Hsing, Ann W.] Canc Prevent Inst Calif, Fremont, CA USA.
RI Zhou, Cindy /H-2165-2015
OI Zhou, Cindy /0000-0003-4814-4305
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 3260
DI 10.1158/1538-7445.AM2014-3260
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910200260
ER

PT J
AU Zhou, Y
   Kim, YS
   Milenic, DE
   Baidoo, KE
   Brechbiel, MW
AF Zhou, Yang
   Kim, Young-Seung
   Milenic, Diane E.
   Baidoo, Kwamena E.
   Brechbiel, Martin W.
TI In vitro & in vivo analysis of indocyanine green-labeled panitumumab for
   optical imaging: a cautionary tale
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhou, Yang] NIH, Rockville, MD USA.
   [Kim, Young-Seung; Milenic, Diane E.; Baidoo, Kwamena E.; Brechbiel, Martin W.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4290
DI 10.1158/1538-7445.AM2014-4290
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910202266
ER

PT J
AU Zhu, F
   Chen, ZS
   Willette-Brown, J
   Lomada, D
   Davis, SR
   Back, T
   Yoshimura, T
   Sun, ZH
   Wu, XL
   Wiltrout, R
   Richie, E
   Siebenlist, U
   Trichieri, G
   Hu, YL
AF Zhu, Feng
   Chen, Zhisong
   Willette-Brown, Jami
   Lomada, Dakshayani
   Davis, Sean R.
   Back, Timothy
   Yoshimura, Teizo
   Sun, Zhonghe
   Wu, Xiaolin
   Wiltrout, Robert
   Richie, Ellen
   Siebenlist, Ulrich
   Trichieri, Giorgio
   Hu, Yinling
TI IKK alpha bridges central tolerance to innate immunity and inflammation
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zhu, Feng; Chen, Zhisong; Willette-Brown, Jami; Back, Timothy; Yoshimura, Teizo; Wiltrout, Robert; Trichieri, Giorgio; Hu, Yinling] NCI, Frederick, MD 21701 USA.
   [Lomada, Dakshayani; Richie, Ellen] Univ Texas MD Anderson Canc Ctr, Smithville, TX USA.
   [Davis, Sean R.] NCI, Bethesda, MD 20892 USA.
   [Sun, Zhonghe; Wu, Xiaolin] Leidos Biomed Res Inc, Lab Mol Technol, Frederick, MD USA.
   [Siebenlist, Ulrich] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 4873
DI 10.1158/1538-7445.AM2014-4873
PG 2
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910203337
ER

PT J
AU Zigmont, VA
   Ryan, BM
   Jen, J
   Robles, AI
   McClary, C
   Calhoun, K
   Bowman, ED
   Vahakangas, K
   Greathouse, KL
   Yi, W
   Wenzlaff, AS
   Deng, B
   Yang, P
   Schwartz, AG
   Harris, CC
   Marston, SO
AF Zigmont, Victoria A.
   Ryan, Brid M.
   Jen, Jin
   Robles, Ana I.
   McClary, Cain
   Calhoun, Kara
   Bowman, Elise D.
   Vahakangas, Kirsi
   Greathouse, K. Leigh
   Yi, Wang
   Wenzlaff, Angela S.
   Deng, Bo
   Yang, Ping
   Schwartz, Ann G.
   Harris, Curtis C.
   Marston, Susan Olivo
TI Childhood exposure to secondhand smoke, nicotine dependence, and DRD1
   are associated with lung cancer risk
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
   (AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Zigmont, Victoria A.; Marston, Susan Olivo] Ohio State Univ, Columbus, OH 43210 USA.
   [Ryan, Brid M.; Robles, Ana I.; McClary, Cain; Calhoun, Kara; Bowman, Elise D.; Greathouse, K. Leigh; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Jen, Jin; Deng, Bo] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
   [Jen, Jin; Deng, Bo] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA.
   [Vahakangas, Kirsi] Univ Eastern Finland, Sch Pharm Toxicol, Fac Hlth Sci, Kuopio, Finland.
   [Yi, Wang] Wenzhou Med Univ, Sch Environm Sci & Publ Hlth, Div Prevent Med, Wenzhou, Zhejiang, Peoples R China.
   [Wenzlaff, Angela S.; Schwartz, Ann G.] Wayne State Univ Sch Med, Karmanos Canc Inst, Dept Oncol, Detroit, MI USA.
   [Yang, Ping] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 2156
DI 10.1158/1538-7445.AM2014-2156
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906902368
ER

PT J
AU Dueck, AC
   Mitchell, SA
   Mendoza, TR
   Bennett, AV
   Rogak, L
   Atkinson, TM
   Li, YL
   Reeve, BB
   Basch, E
AF Dueck, Amylou C.
   Mitchell, Sandra A.
   Mendoza, Tito R.
   Bennett, Antonia V.
   Rogak, Lauren
   Atkinson, Thomas M.
   Li, Yuelin
   Reeve, Bryce B.
   Basch, Ethan
CA Natl Canc Inst PRO CTCAE Res Grp
TI Responsiveness of Items from the Patient-Reported Outcomes version of
   the Common Terminology Criteria for Adverse Events
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Dueck, Amylou C.] Mayo Clin, Scottsdale, AZ USA.
   [Mitchell, Sandra A.] NCI, Bethesda, MD 20892 USA.
   [Mendoza, Tito R.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Bennett, Antonia V.; Reeve, Bryce B.; Basch, Ethan] Univ N Carolina, Chapel Hill, NC USA.
   [Rogak, Lauren; Atkinson, Thomas M.; Li, Yuelin] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 203.1
BP 37
EP 38
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800096
ER

PT J
AU Bennett, AV
   Reeve, BB
   Basch, E
   Mitchell, SA
   Meeneghan, M
   Battaglini, C
   Smith-Ryan, A
   Shatten, C
   Shea, TC
   Wood, WA
AF Bennett, Antonia V.
   Reeve, Bryce B.
   Basch, Ethan
   Mitchell, Sandra A.
   Meeneghan, Mathew
   Battaglini, Claudio
   Smith-Ryan, Abbie
   Shatten, Charlotte
   Shea, Thomas C.
   Wood, William A.
TI Evaluation of pedometry as a patient-centered outcome in patients
   undergoing hematopoietic stem cell transplant (HSCT): A comparison of
   pedometry and patient-reports of symptoms, physical activity, health,
   and quality of life
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Bennett, Antonia V.; Reeve, Bryce B.; Basch, Ethan; Meeneghan, Mathew; Battaglini, Claudio; Smith-Ryan, Abbie; Shatten, Charlotte; Shea, Thomas C.; Wood, William A.] Univ N Carolina, Chapel Hill, NC USA.
   [Mitchell, Sandra A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 205.1
BP 41
EP 41
PG 1
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800106
ER

PT J
AU Arnold, BJ
   Mitchell, SA
   Lent, L
   Mendoza, TR
   Rogak, L
   Barragan, N
   Willis, GB
   Medina, M
   Lechner, SC
   Harness, J
   Basch, E
AF Arnold, Benjamin J.
   Mitchell, Sandra A.
   Lent, Lauren
   Mendoza, Tito R.
   Rogak, Lauren
   Barragan, Natalie
   Willis, Gordon B.
   Medina, Mauricio
   Lechner, Suzanne C.
   Harness, Jay
   Basch, Ethan
TI Linguistic validation of the Spanish translation of the US National
   Cancer Institute's Patient- Reported Outcomes version of the Common
   Terminology Criteria for Adverse Events
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Arnold, Benjamin J.; Lent, Lauren] FACITtrans, Elmhurst, IL USA.
   [Mitchell, Sandra A.; Willis, Gordon B.; Medina, Mauricio] NCI, Bethesda, MD 20892 USA.
   [Lent, Lauren] FACIT Org, Elmhurst, IL USA.
   [Mendoza, Tito R.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Rogak, Lauren; Barragan, Natalie] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Lechner, Suzanne C.] Univ Miami, Miami, FL USA.
   [Harness, Jay] St Joseph Hosp Orange, Orange, CA USA.
   [Basch, Ethan] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 209.1
BP 51
EP 52
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800129
ER

PT J
AU Litzelman, K
AF Litzelman, Kristin
TI Quality of life spillover among spouses with and without cancer
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Litzelman, Kristin] NCI, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 305.5
BP 65
EP 66
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800165
ER

PT J
AU Basch, E
   Pugh, SL
   Dueck, AC
   Mitchell, SA
   Berk, L
   Rogak, L
   Gatewood, M
   Reeve, BB
   Mendoza, TR
   O'Mara, A
   Denicoff, A
   Minasian, L
   Fogh, S
   Roof, K
   Moore, JK
   Gergel, T
   Stephans, K
   Rimner, A
   DeNittis, A
   Bruner, DW
AF Basch, Ethan
   Pugh, Stephanie L.
   Dueck, Amylou C.
   Mitchell, Sandra A.
   Berk, Lawrence
   Rogak, Lauren
   Gatewood, Marcha
   Reeve, Bryce B.
   Mendoza, Tito R.
   O'Mara, Ann
   Denicoff, Andrea
   Minasian, Lori
   Fogh, Shannon
   Roof, Kevin
   Moore, Joan K.
   Gergel, Thomas
   Stephans, Kevin
   Rimner, Andreas
   DeNittis, Albert
   Bruner, Deborah W.
TI Feasibility of Patient Reporting of Symptomatic Adverse Events via the
   PRO-CTCAE in a Radiation Therapy Oncology Group (RTOG) Cooperative Group
   Clinical Trial
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Basch, Ethan; Reeve, Bryce B.] Univ N Carolina, Chapel Hill, NC USA.
   [Pugh, Stephanie L.] NRG Oncol Stat & Data Management Ctr, Pittsburgh, PA USA.
   [Dueck, Amylou C.] Mayo Clin, Scottsdale, AZ USA.
   [Mitchell, Sandra A.] CRNP AOCN Natl Canc Inst, Bethesda, MD USA.
   [Berk, Lawrence] Univ S Florida, Tampa, FL 33620 USA.
   [Rogak, Lauren; Rimner, Andreas] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Gatewood, Marcha; Bruner, Deborah W.] Emory Univ, Atlanta, GA 30322 USA.
   [Mendoza, Tito R.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [O'Mara, Ann; Denicoff, Andrea; Minasian, Lori] NCI, Bethesda, MD 20892 USA.
   [Fogh, Shannon] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Roof, Kevin] Southeast Canc Control Consortium Inc CCOP, Winston Salem, NC USA.
   [Moore, Joan K.] York Canc Ctr, New York, NY USA.
   [Gergel, Thomas] Geisinger Med Ctr CCOP, Danville, PA USA.
   [Stephans, Kevin] Cleveland Clin Fdn, Cleveland, OH USA.
   [DeNittis, Albert] Main Line CCOP, Swarthmore, PA USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 1080
BP 97
EP 98
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800250
ER

PT J
AU Mendoza, TR
   Bennett, AV
   Mitchell, SA
   Reeve, BB
   Atkinson, TM
   Li, YL
   Rogak, L
   Dueck, AC
   Basch, E
AF Mendoza, Tito R.
   Bennett, Antonia V.
   Mitchell, Sandra A.
   Reeve, Bryce B.
   Atkinson, Thomas M.
   Li, Yuelin
   Rogak, Lauren
   Dueck, Amylou C.
   Basch, Ethan
CA Natl Canc Inst PRO- CTCAE Res Grp
TI Impact of recall period on the accuracy of selected items from the US
   National Cancer Institute's Patient-Reported Outcomes Version of the
   Common Terminology Criteria for Adverse Events (PRO-CTCAE)
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Mendoza, Tito R.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Bennett, Antonia V.; Reeve, Bryce B.; Basch, Ethan] Univ N Carolina, Chapel Hill, NC USA.
   [Mitchell, Sandra A.] NCI, Bethesda, MD 20892 USA.
   [Atkinson, Thomas M.; Li, Yuelin; Rogak, Lauren] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [Dueck, Amylou C.] Mayo Clin, Scottsdale, AZ USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2014
VL 23
SU 1
MA 2104
BP 141
EP 142
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA CF6XJ
UT WOS:000352699800362
ER

PT J
AU Hoenen, T
   Feldmann, H
AF Hoenen, Thomas
   Feldmann, Heinz
TI Reverse genetics systems as tools for the development of novel therapies
   against filoviruses
SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
LA English
DT Review
DE antiviral screening; Ebola virus; filoviruses; marburg virus; minigenome
   system; recombinant virus; reporter-expressing virus; reverse genetics;
   transcription and replication-competent particle system
ID VIRUS-LIKE PARTICLES; SMALL-MOLECULE INHIBITOR; EBOLA-VIRUS;
   HIGH-THROUGHPUT; MARBURG-VIRUS; HEMORRHAGIC-FEVER; ANTIVIRAL ACTIVITY;
   CELL-CULTURE; HOST-CELLS; IN-VITRO
AB Filoviruses cause severe hemorrhagic fevers with case fatality rates of up to 90%, for which no antivirals are currently available. Their categorization as biosafety level 4 agents restricts work with infectious viruses to a few maximum containment laboratories worldwide, which constitutes a significant obstacle for the development of countermeasures. Reverse genetics facilitates the generation of recombinant filoviruses, including reporter-expressing viruses, which have been increasingly used for drug screening and development in recent years. Further, reverse-genetics based lifecycle modeling systems allow modeling of the filovirus lifecycle without the need for a maximum containment laboratory and have recently been optimized for use in high-throughput assays. The availability of these reverse genetics-based tools will significantly improve our ability to find novel antivirals against filoviruses.
C1 [Hoenen, Thomas; Feldmann, Heinz] NIH, Div Intramural Res, Virol Lab, Hamilton, MT 59840 USA.
RP Hoenen, T (reprint author), NIH, Div Intramural Res, Virol Lab, 903 South 4th St, Hamilton, MT 59840 USA.
EM thomas.hoenen@nih.gov
OI Hoenen, Thomas/0000-0002-5829-6305
FU Intramural Research Program of the NIH, NIAID
FX This research was supported by the Intramural Research Program of the
   NIH, NIAID. The authors have no other relevant affiliations or financial
   involvement with any organization or entity with a financial interest in
   or financial conflict with the subject matter or materials discussed in
   the manuscript apart from those disclosed.
NR 60
TC 10
Z9 10
U1 0
U2 19
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
   ENGLAND
SN 1478-7210
EI 1744-8336
J9 EXPERT REV ANTI-INFE
JI Expert Rev. Anti-Infect. Ther.
PD OCT
PY 2014
VL 12
IS 10
BP 1253
EP 1263
DI 10.1586/14787210.2014.948848
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CE8YK
UT WOS:000352129800008
PM 25169588
ER

PT J
AU Sorkin, BC
   Camp, KM
   Haggans, CJ
   Deuster, PA
   Haverkos, L
   Maruvada, P
   Witt, E
   Coates, PM
AF Sorkin, Barbara C.
   Camp, Kathryn M.
   Haggans, Carol J.
   Deuster, Patricia A.
   Haverkos, Lynne
   Maruvada, Padma
   Witt, Ellen
   Coates, Paul M.
TI Executive summary of NIH workshop on the Use and Biology of Energy
   Drinks: Current Knowledge and Critical Gaps
SO NUTRITION REVIEWS
LA English
DT Review
DE behavior; caffeine; energy drinks; epidemiology
ID COLLEGE-STUDENTS; CONSUMPTION; ALCOHOL
AB Sales of energy drinks in the United States reached $12.5 billion in 2012. Emergency department visits related to consumption of these products have increased sharply, and while these numbers remain small relative to product sales, they raise important questions regarding biological and behavioral effects. Although some common ingredients of energy drinks have been extensively studied (e.g., caffeine, B vitamins, sugars, inositol), data on other ingredients (e.g., taurine) are limited. Summarized here are data presented elsewhere in this issue on the prevalence and patterns of caffeine-containing energy drink use, the effects of these products on alertness, fatigue, cognitive functions, sleep, mood, homeostasis, as well as on exercise physiology and metabolism, and the biological mechanisms mediating the observed effects. There are substantial data on the effects of some energy drink ingredients, such as caffeine and sugars, on many of these outcomes; however, even for these ingredients many controversies and gaps remain, and data on other ingredients in caffeine-containing energy drinks, and on ingredient interactions, are sparse. This summary concludes with a discussion of critical gaps in the data and potential next steps. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Sorkin, Barbara C.; Camp, Kathryn M.; Haggans, Carol J.; Coates, Paul M.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
   [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Haverkos, Lynne] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
   [Maruvada, Padma] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Witt, Ellen] NIAAA, NIH, Bethesda, MD USA.
RP Sorkin, BC (reprint author), NIH, Off Dietary Supplements, 6100 Execut Blvd,Ste 3B01, Bethesda, MD 20892 USA.
EM sorkinb@od.nih.gov
RI Deuster, Patricia/G-3838-2015
OI Deuster, Patricia/0000-0002-7895-0888
FU US National Institutes of Health; Uniformed Services University of the
   Health Sciences
FX This work was supported by the US National Institutes of Health and by
   the Uniformed Services University of the Health Sciences.
NR 44
TC 5
Z9 5
U1 2
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD OCT
PY 2014
VL 72
SU 1
SI SI
BP 1
EP 8
DI 10.1111/nure.12154
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CB9PR
UT WOS:000349964500001
PM 25293538
ER

PT J
AU Bailey, RL
   Saldanha, LG
   Gahche, JJ
   Dwyer, JT
AF Bailey, Regan L.
   Saldanha, Leila G.
   Gahche, Jaime J.
   Dwyer, Johanna T.
TI Estimating caffeine intake from energy drinks and dietary supplements in
   the United States
SO NUTRITION REVIEWS
LA English
DT Review
DE beverages; caffeine; dietary supplements; energy; energy drinks
AB No consistent definition exists for energy products in the United States. These products have been marketed and sold as beverages (conventional foods), energy shots (dietary supplements), and in pill or tablet form. Recently, the number of available products has surged, and formulations have changed to include caffeine. To help characterize the use of caffeine-containing energy products in the United States, three sources of data were analyzed: sales data, data from federal sources, and reports from the Drug Abuse Warning Network. These data indicate that sales of caffeine-containing energy products and emergency room visits involving their consumption appear to be increasing over time. Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 indicate that 2.7% [standard error (SE) 0.2%] of the US population >= 1 year of age used a caffeine-containing energy product, providing approximately 150-200 mg/day of caffeine per day in addition to caffeine from traditional sources like coffee, tea, and colas. The highest usage of these products was among males between the ages of 19 and 30 years (7.6%, SE 1.0). Although the prevalence of caffeine-containing energy product use remains low overall in the US population, certain subgroups appear to be using these products in larger amounts. Several challenges remain in determining the level of caffeine exposure from and accurate usage patterns of caffeine-containing energy products. Published 2014. This article is a U.S. Government work and is in the public domain in the USA
C1 [Bailey, Regan L.; Saldanha, Leila G.; Dwyer, Johanna T.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
   [Gahche, Jaime J.] CDC, Natl Hlth & Nutr Examinat Survey Planning Branch, Natl Ctr Hlth Stat, Hyattsville, MD USA.
RP Bailey, RL (reprint author), NIH, Off Dietary Supplements, 6100 Execut Blvd MSC 7517,Room 3B01, Bethesda, MD 20892 USA.
EM baileyr@mail.nih.gov
OI Dwyer, Johanna/0000-0002-0783-1769
FU Office of Dietary Supplement at the National Institutes of Health
FX This work was fully funded by the Office of Dietary Supplement at the
   National Institutes of Health.
NR 14
TC 10
Z9 10
U1 11
U2 71
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD OCT
PY 2014
VL 72
SU 1
SI SI
BP 9
EP 13
DI 10.1111/nure.12138
PG 5
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CB9PR
UT WOS:000349964500002
PM 25293539
ER

PT J
AU Mothe, B
   Hu, XT
   Llano, A
   Rosati, M
   Olvera, A
   Kulkarni, V
   Valentin, A
   Alicea, C
   Sardesai, NJ
   Rocafort, M
   Crespo, M
   Carrillo, J
   Marco, A
   Mullins, JI
   Dorrell, L
   Hanke, T
   Clotet, B
   Pavlakis, GN
   Felber, BK
   Brander, C
AF Mothe, Beatriz
   Hu, Xintao
   Llano, Anuska
   Rosati, Margherita
   Olvera, Alex
   Kulkarni, Viraj
   Valentin, Antonio
   Alicea, Candido
   Sardesai, Niranjan J.
   Rocafort, Muntsa
   Crespo, Manel
   Carrillo, Jorge
   Marco, Andres
   Mullins, James I.
   Dorrell, Lucy
   Hanke, Tomas
   Clotet, Bonaventura
   Pavlakis, George N.
   Felber, Barbara K.
   Brander, Christian
TI A Novel T-cell Vaccine Eliciting T-cell Specificities Associated with
   Control of HIV-1 In Humans Is Highly Immunogenic in Mice and Macaques
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mothe, Beatriz; Llano, Anuska; Olvera, Alex; Rocafort, Muntsa; Carrillo, Jorge; Clotet, Bonaventura; Brander, Christian] Hosp Badalona Germans Trias & Pujol, IrsiCaixa AIDS Res Inst HIVACAT, Badalona, Spain.
   [Mothe, Beatriz; Clotet, Bonaventura; Brander, Christian] Univ Cent Catalunya, Univ Vic, Vic, Spain.
   [Hu, Xintao; Rosati, Margherita; Kulkarni, Viraj; Valentin, Antonio; Alicea, Candido; Pavlakis, George N.; Felber, Barbara K.] NCI, Human Retrovirus Sect, Frederick, MD 21701 USA.
   [Sardesai, Niranjan J.] Inovio Pharmaceut Inc, Blue Bell, PA USA.
   [Crespo, Manel] Hosp Valle De Hebron, HIV Unit, Barcelona, Spain.
   [Marco, Andres] Ctr Penitenciaris BCN, Barcelona, Spain.
   [Mullins, James I.] Univ Washington, Seattle, WA 98195 USA.
   [Dorrell, Lucy] Univ Oxford, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England.
   [Hanke, Tomas] Univ Oxford, Jenner Inst, Oxford, England.
   [Clotet, Bonaventura] Univ Autonoma Barcelona, E-08193 Barcelona, Spain.
   [Brander, Christian] ICREA, Barcelona, Spain.
RI Crespo, Manuel/H-8868-2015
OI Crespo, Manuel/0000-0001-9016-0515
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA29.06
BP A76
EP A76
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400172
ER

PT J
AU Koyasu, S
   Nakamoto, Y
   Harada, H
   Tsuji, Y
   Kimura, H
   Sano, K
   Nobashi, T
   Togashi, K
AF Koyasu, S.
   Nakamoto, Y.
   Harada, H.
   Tsuji, Y.
   Kimura, H.
   Sano, K.
   Nobashi, T.
   Togashi, K.
TI Evaluation of tumour hypoxia and cancer stroma using F-18-misonidazole
   PET and dynamic contrast enhanced CT in tumor-bearing mice models
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Meeting Abstract
CT Annual Congress of the European-Association-of-Nuclear-Medicine (EANM)
CY OCT 18-22, 2014
CL Gothenburg, SWEDEN
SP European Assoc Nucl Med
C1 [Koyasu, S.; Nakamoto, Y.; Harada, H.; Tsuji, Y.; Kimura, H.; Sano, K.; Nobashi, T.; Togashi, K.] Kyoto Univ, Grad Sch Med, Kyoto, Japan.
   [Koyasu, S.] NCI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD OCT
PY 2014
VL 41
SU 2
MA P102
BP S387
EP S387
PG 1
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CA3YT
UT WOS:000348841901099
ER

PT J
AU Papadakis, GZ
   Bagci, U
   Xu, Z
   Kissell, KA
   Stratakis, CA
   Mollura, DJ
AF Papadakis, G. Z.
   Bagci, U.
   Xu, Z.
   Kissell, K. A.
   Stratakis, C. A.
   Mollura, D. J.
TI Detection and Quantification of Brown Fat Tissue using PET-CT Scans: A
   Novel Computer Aided Detection System
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Meeting Abstract
CT Annual Congress of the European-Association-of-Nuclear-Medicine (EANM)
CY OCT 18-22, 2014
CL Gothenburg, SWEDEN
SP European Assoc Nucl Med
C1 [Papadakis, G. Z.; Bagci, U.; Xu, Z.; Kissell, K. A.; Stratakis, C. A.; Mollura, D. J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD OCT
PY 2014
VL 41
SU 2
MA OP123
BP S187
EP S188
PG 2
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CA3YT
UT WOS:000348841900077
ER

PT J
AU Bosco, JJ
   Nicholls, K
   McComish, J
   Bleasel, K
   Unglik, G
   Choo, S
   Flanagan, K
   Fulcher, DA
   Naselli, G
   Martinuzzi, E
   Holland, SM
   Browne, SK
   Harrison, LC
AF Bosco, J. J.
   Nicholls, K.
   McComish, J.
   Bleasel, K.
   Unglik, G.
   Choo, S.
   Flanagan, K.
   Fulcher, D. A.
   Naselli, G.
   Martinuzzi, E.
   Holland, S. M.
   Browne, S. K.
   Harrison, L. C.
TI Rituximab Treatment in Two Patients with Anti-Interferon Gamma
   Autoantibody-Associated Disseminated Mycobacterial Infections
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Bosco, J. J.; Naselli, G.; Harrison, L. C.] Walter & Eliza Hall Inst Med Res, Mol Med Div, Melbourne, Vic 3050, Australia.
   [Nicholls, K.; McComish, J.; Bleasel, K.; Unglik, G.] Royal Melbourne Hosp, Dept Clin Immunol & Allergy, Melbourne, Vic, Australia.
   [Choo, S.] Royal Childrens Hosp, Immunol Lab, Parkville, Vic 3052, Australia.
   [Flanagan, K.] Launceston Hosp, Infect Dis Serv, Launceston, Tas, Australia.
   [Fulcher, D. A.] Inst Clin Pathol & Med Res, Immunopathol & Flow Cytometry Unit, Westmead, NSW, Australia.
   [Martinuzzi, E.] INSERM, Paris, Australia.
   [Holland, S. M.; Browne, S. K.] Natl Inst Hlth, Lab Clin Infect Dis, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0100
BP S277
EP S277
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100293
ER

PT J
AU Boztug, K
   Jarvinen, PM
   Salzer, E
   Racek, T
   Monch, S
   Garncarz, W
   Gertz, EM
   Antonopoulos, A
   Haslam, S
   Schieck, L
   Puchalka, J
   Diestelhorst, J
   Appaswamy, G
   Lescoeur, B
   Giambruno, R
   Bigenzahn, JW
   Elling, U
   Pfeifer, D
   Welte, K
   Brandes, G
   Sherkat, R
   ten Bosch, JVW
   Rezaei, N
   Etzioni, A
   Bellanne-Chantelot, C
   Superti-Furga, G
   Penninger, JM
   Bennett, KL
   von Blume, J
   Dell, A
   Donadieu, J
   Klein, C
AF Boztug, K.
   Jaervinen, P. M.
   Salzer, E.
   Racek, T.
   Moench, S.
   Garncarz, W.
   Gertz, E. M.
   Antonopoulos, A.
   Haslam, S.
   Schieck, L.
   Puchalka, J.
   Diestelhorst, J.
   Appaswamy, G.
   Lescoeur, B.
   Giambruno, R.
   Bigenzahn, J. W.
   Elling, U.
   Pfeifer, D.
   Welte, K.
   Brandes, G.
   Sherkat, R.
   ten Bosch, J. van der Werff
   Rezaei, N.
   Etzioni, A.
   Bellanne-Chantelot, C.
   Superti-Furga, G.
   Penninger, J. M.
   Bennett, K. L.
   von Blume, J.
   Dell, A.
   Donadieu, J.
   Klein, C.
TI Human JAGN1 Deficiency Causes Disturbed Myeloid Cell Homeostasis and
   Severe Congenital Neutropenia
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Boztug, K.; Salzer, E.; Garncarz, W.; Giambruno, R.; Bigenzahn, J. W.; Superti-Furga, G.; Bennett, K. L.] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1010 Vienna, Austria.
   [Jaervinen, P. M.; Racek, T.; Moench, S.; Puchalka, J.; Diestelhorst, J.; Klein, C.] Univ Munich, Dr von Hauner Childrens Hosp, Dept Pediat, Munich, Germany.
   [Gertz, E. M.] NIH, Computat Biol Branch, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA.
   [Antonopoulos, A.; Haslam, S.; Dell, A.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London, England.
   [Schieck, L.; Appaswamy, G.; Welte, K.] Hannover Med Sch, Dept Pediat Hematol Oncol, Hannover, Germany.
   [Lescoeur, B.] Hosp R Debre, Dept Hematol, Paris, France.
   [Elling, U.; Penninger, J. M.] Austrian Acad Sci, IMBA Inst Mol Biotechnol, A-1010 Vienna, Austria.
   [Pfeifer, D.] Univ Med Ctr Freiburg, Dept Hematol, Oncol Genom Core Lab, Freiburg, Germany.
   [Brandes, G.] Hannover Med Sch, Dept Cell Biol, Hannover, Germany.
   [Sherkat, R.] Isfahan Univ Med Sci, Dept Infect Dis, Infect Dis Res Ctr, Esfahan, Iran.
   [ten Bosch, J. van der Werff] Hosp Free Univ Brussels, Dept Pediat, Brussels, Belgium.
   [Rezaei, N.] Univ Tehran Med Sci, Childrens Med Ctr, Ctr Excellence, Res Ctr Immunodeficiencies Pediat, Tehran, Iran.
   [Etzioni, A.] Technion Israel Inst Technol, Rappaport Sch Med, Div Pediat & Immunol, Haifa, Israel.
   [Bellanne-Chantelot, C.] Univ Paris 06, Pitie Salpetriere Hosp, AP HP, Genet Dept, Paris, France.
   [von Blume, J.] Max Planck Inst Biochem, D-82152 Martinsried, Germany.
   [Donadieu, J.] Armand Trousseau Childrens Hosp, Pediat Hematol Unit, Histocytol Reference Ctr, Paris, France.
RI Superti-Furga, Giulio/F-4755-2015; Rezaei, Nima/B-4245-2008
OI Superti-Furga, Giulio/0000-0002-0570-1768; Rezaei,
   Nima/0000-0002-3836-1827
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0747
BP S151
EP S152
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100022
ER

PT J
AU Deenick, EK
   Ives, ML
   Wilson, RP
   Uzel, G
   Tangye, SG
AF Deenick, E. K.
   Ives, M. L.
   Wilson, R. P.
   Uzel, G.
   Tangye, S. G.
TI The Role of STAT3 in the Differentiation and Function of Unconventional
   T Cells
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Deenick, E. K.; Ives, M. L.; Wilson, R. P.; Tangye, S. G.] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia.
   [Uzel, G.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0414
BP S441
EP S441
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100651
ER

PT J
AU Di Pierro, V
   Zuntini, R
   Bacchelli, E
   Schaffer, A
   Grimbacher, B
   Quinti, I
   Ferrari, S
AF Di Pierro, V.
   Zuntini, R.
   Bacchelli, E.
   Schaffer, A.
   Grimbacher, B.
   Quinti, I.
   Ferrari, S.
TI A New Gene Involved in an Autosomal Dominant Form of Common Variable
   Immunodeficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Di Pierro, V.; Zuntini, R.; Ferrari, S.] Univ Hosp S Orsola Malpighi, Med Genet Lab, Bologna, Italy.
   [Bacchelli, E.] Univ Bologna, FaBiT, Bologna, Italy.
   [Schaffer, A.] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA.
   [Grimbacher, B.] Univ Freiburg Klinikum, Ctr Chron Immunodeficiency, Freiburg, Germany.
   [Quinti, I.] Univ Roma La Sapienza, Ctr Primary Immunodeficiency, I-00185 Rome, Italy.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0184
BP S399
EP S399
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100561
ER

PT J
AU Engelhardt, KR
   Gertz, EM
   Schaffer, AA
   Keles, S
   Sigmund, EC
   Ceja, R
   Sassi, A
   Graham, L
   Masaad, MJ
   Mellouli, F
   Ben-Mustapha, I
   Khemiri, M
   Kilic, SS
   Etzioni, A
   Freeman, AF
   Thiel, J
   Schulze, I
   Al-Herz, W
   Metin, A
   Sanal, O
   Tezcan, I
   Yeganeh, M
   Niehues, T
   Dueckers, G
   Weinspach, S
   Patiroglu, T
   Unal, E
   Dasouki, M
   Yilamaz, M
   Genel, F
   Aytekin, C
   Kutukculer, N
   Somer, A
   Kilic, M
   Reisli, I
   Camcioglu, Y
   Gennery, AR
   Cant, AJ
   Jones, A
   Gaspar, HB
   Arkwright, PD
   Pietrogrande, MC
   Baz, Z
   Al-Tamemi, S
   Lougaris, V
   Lefranc, G
   Megarbane, A
   Boutros, J
   Galal, N
   Bejaoui, M
   Barbouche, MR
   Geha, RS
   Chatila, TA
   Grimbacher, B
AF Engelhardt, K. R.
   Gertz, E. M.
   Schaeffer, A. A.
   Keles, S.
   Sigmund, E. C.
   Ceja, R.
   Sassi, A.
   Graham, L.
   Masaad, M. J.
   Mellouli, F.
   Ben-Mustapha, I.
   Khemiri, M.
   Kilic, S. S.
   Etzioni, A.
   Freeman, A. F.
   Thiel, J.
   Schulze, I.
   Al-Herz, W.
   Metin, A.
   Sanal, O.
   Tezcan, I.
   Yeganeh, M.
   Niehues, T.
   Dueckers, G.
   Weinspach, S.
   Patiroglu, T.
   Unal, E.
   Dasouki, M.
   Yilamaz, M.
   Genel, F.
   Aytekin, C.
   Kutukculer, N.
   Somer, A.
   Kilic, M.
   Reisli, I.
   Camcioglu, Y.
   Gennery, A. R.
   Cant, A. J.
   Jones, A.
   Gaspar, H. B.
   Arkwright, P. D.
   Pietrogrande, M. C.
   Baz, Z.
   Al-Tamemi, S.
   Lougaris, V.
   Lefranc, G.
   Megarbane, A.
   Boutros, J.
   Galal, N.
   Bejaoui, M.
   Barbouche, M. R.
   Geha, R. S.
   Chatila, T. A.
   Grimbacher, B.
TI The Extended Clinical Phenotype of 58 Patients with Dock8 Deficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Engelhardt, K. R.] Royal Free Hosp, Dept Immunol & Mol Pathol, London NW3 2QG, England.
   [Engelhardt, K. R.] UCL, London, England.
   [Gertz, E. M.; Schaeffer, A. A.] NIH, US Dept HHS, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA.
   [Keles, S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA.
   [Sigmund, E. C.; Thiel, J.; Schulze, I.; Grimbacher, B.] Univ Med Ctr Freiburg, CCI, Freiburg, Germany.
   [Ceja, R.; Geha, R. S.; Chatila, T. A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Div Immunol Allergy & Rheumatol, Los Angeles, CA 90095 USA.
   [Sassi, A.] Pasteur Inst Tunis, Lab Vaccinol & Mol Genet, Tunis El Manar, Tunisia.
   [Sassi, A.] Univ Tunis El Manar, Tunis El Manar, Tunisia.
   [Graham, L.] Royal Free Hosp, London NW3 2QG, England.
   [Graham, L.] UCL, Dept Immunol & Mol Pathol, London, England.
   [Masaad, M. J.] Childrens Hosp, Div Immunol, Boston, MA 02115 USA.
   [Mellouli, F.; Khemiri, M.; Bejaoui, M.] Bone Marrow Transplantat Ctr, Dept Pediat, Tunis, Tunisia.
   [Ben-Mustapha, I.] Pasteur Inst Tunis & Univ, Lab Immunol Vaccinol & Mol Genet, Tunis El Manar, Tunisia.
   [Kilic, S. S.] Uludag Univ, Fac Med, Dept Pediat Immunol, Bursa, Turkey.
   [Etzioni, A.] Meyers Children Hosp Rambam Hlth Care Campus, Haifa, Israel.
   [Etzioni, A.] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Freeman, A. F.] NIH, Lab Clin Infect Dis, Natl Dept Hlth & Human Serv, Inst Allergy & Infect Dis, Bethesda, MD 20892 USA.
   [Al-Herz, W.] Kuwait Univ, Fac Med, Dept Pediat, Kuwait, Kuwait.
   [Al-Herz, W.] Allergy & Clin Immunol Unit, Kuwait, Kuwait.
   [Metin, A.] SB Ankara Diskapi Childrens Hosp, Pediat Immunol Unit, Ankara, Turkey.
   [Sanal, O.; Tezcan, I.] Hacettepe Univ, Childrens Hosp, Pediat Immunol Unit, Ankara, Turkey.
   [Yeganeh, M.] Univ Tehran Med Sci, Immunol Asthma & Allergy Res Inst, Childrens Med Ctr, Tehran, Iran.
   [Niehues, T.; Dueckers, G.] HELIOS Klinikum Krefeld, Zentrum Kinder & Jugendmed, Krefeld, Germany.
   [Weinspach, S.] Univ Dusseldorf, Dept Pediat Oncol Hematol & Clini Immunol, Ctr Child & Adolescent Med, Dusseldorf, Germany.
   [Patiroglu, T.; Unal, E.] Erciyes Univ, Fac Med, Dept Pediat, Div Pediat Hematol & Immunol Oncol, Kaysery, Turkey.
   [Dasouki, M.] Univ Kansas, Med Ctr, Dept Pediat, Kansas City, KS USA.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Cukurova Univ, Adana, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Behcet Uz State Hosp, Div Pediat Immunol, Izmir, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Dr Sami Ulus Matern & Childrens Hlth & Dis Traini, Dept Pediat Immunol, Ankara, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Ege Univ, Fac Med, Dept Pediat, Izmir, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Firat Univ, Istanbul Med Fac, Div Infect Dis & Immunol, TR-23169 Elazig, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Konya Necmettin Erbakan Univ, Div Pediat Allergy & Immunol, Konya, Turkey.
   [Yilamaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I.; Camcioglu, Y.] Istanbul Univ, Cerrahpasa Med Fac, Div Pediat Allergy Immunol & Infect Dis, Istanbul, Turkey.
   [Gennery, A. R.; Cant, A. J.] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Jones, A.; Gaspar, H. B.] Great Ormond St Hosp Sick Children, Dept Immunol, London WC1N 3JH, England.
   [Arkwright, P. D.] Univ Manchester, Royal Manchester Childrens Hosp, Manchester, Lancs, England.
   [Pietrogrande, M. C.] Univ Milan, Fdn Policlin IRCCS, Dept Pediat, Milan, Italy.
   [Baz, Z.] St George Hosp Univ, Med Ctr, Dept Pediat, Beirut, Lebanon.
   [Al-Tamemi, S.] Sultan Qaboos Univ, Dept Pediat, Muscat, Oman.
   [Lougaris, V.] Univ Brescia, Spedali Civili Brescia, Pediat Clin & Inst Mol Med A Nocivelli, Dept Clin & Expt Sci, Brescia, Italy.
   [Lefranc, G.] Univ Montpellier 2, Montpellier, France.
   [Lefranc, G.] CNRS, Inst Human Genet, Montpellier, France.
   [Megarbane, A.] St Joseph Univ, Med Genet Unit, Beirut, Lebanon.
   [Boutros, J.; Galal, N.] Cairo Univ, Primary Immunodeficiency Clin, Specialized Pediat Hosp, Cairo, Egypt.
   [Barbouche, M. R.] Pasteur Inst Tunis, Lab Immunol Vaccinol & Mol Genet, Tunis El Manar, Tunisia.
   [Barbouche, M. R.] Univ Tunis El Manar, Tunis El Manar, Tunisia.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0597
BP S149
EP S150
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100019
ER

PT J
AU Eskandarian, Z
   Zhang, S
   Schaffer, A
   Salzer, U
   Knoll, N
   Vries, E
   Hammarstrom, L
   Espanol, T
   Quinti, I
   Grimbacher, B
AF Eskandarian, Z.
   Zhang, S.
   Schaeffer, A.
   Salzer, U.
   Knoll, N.
   Vries, E.
   Hammarstrom, L.
   Espanol, T.
   Quinti, I.
   Grimbacher, B.
TI In Search of the TACI Modifiers in Common Variable Immunodeficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Eskandarian, Z.; Salzer, U.; Knoll, N.; Grimbacher, B.] Med Univ Ctr, Ctr Chron Immunodeficiency, Freiburg, Germany.
   [Zhang, S.] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA.
   [Schaeffer, A.] NCBI, NIH, Bethesda, MD USA.
   [Vries, E.] Jeroen Bosch Hosp, Dept Pediat, Shertogenbosch, Netherlands.
   [Hammarstrom, L.] Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol, Huddinge, Sweden.
   [Espanol, T.] Vall dHebron Univ Hosp Hosp, Immunol Unit, Barcelona, Spain.
   [Quinti, I.] Univ Roma La Sapienza, Dept Mol Med, I-00185 Rome, Italy.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0321
BP S337
EP S337
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100421
ER

PT J
AU Fliegauf, M
   Frede, N
   Winzer, S
   Schaffer, AA
   van der Meer, JWM
   Grimbacher, B
AF Fliegauf, M.
   Frede, N.
   Winzer, S.
   Schaeffer, A. A.
   van der Meer, J. W. M.
   Grimbacher, B.
TI Haploinsufficiency of the NFkB1 Subunit P50 Causes CVID
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Fliegauf, M.; Frede, N.; Winzer, S.; Grimbacher, B.] Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany.
   [Schaeffer, A. A.] NCBI, US Dept HHS, NIH, Bethesda, MD USA.
   [van der Meer, J. W. M.] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6525 ED Nijmegen, Netherlands.
RI van der Meer, Jos/C-8521-2013
OI van der Meer, Jos/0000-0001-5120-3690
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0845
BP S488
EP S489
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100751
ER

PT J
AU Forbes, LR
   Vargas-Hernandez, A
   Mace, EM
   Free-Man, AF
   Rosenzweig, S
   Holland, SM
   Orange, JS
AF Forbes, L. R.
   Vargas-Hernandez, A.
   Mace, E. M.
   Free-Man, A. F.
   Rosenzweig, S.
   Holland, S. M.
   Orange, J. S.
TI Functional Natural Killer (NK) Cell Deficiency in Patients with Signal
   Transducer and Activator of Transcription (STAT1) Gain of Function
   Mutation (GOF)
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Forbes, L. R.; Vargas-Hernandez, A.; Mace, E. M.; Orange, J. S.] Baylor Coll Med, Ctr Human Immunobiol, Houston, TX 77030 USA.
   [Free-Man, A. F.; Rosenzweig, S.; Holland, S. M.] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0401
BP S339
EP S339
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100425
ER

PT J
AU Grossman, J
   Spinner, M
   Sanchez, L
   Hsu, A
   Olivier, K
   Zerbe, C
   Calvo, K
   Holland, S
   Rosensweig, S
AF Grossman, J.
   Spinner, M.
   Sanchez, L.
   Hsu, A.
   Olivier, K.
   Zerbe, C.
   Calvo, K.
   Holland, S.
   Rosensweig, S.
TI Large Granular Lymphocytes as Predictors of Morbidity and Early
   Mortality in GATA2 Deficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Grossman, J.] Alberta Hlth Serv, Dept Med, Sect Hematol, Calgary, AB, Canada.
   [Spinner, M.; Sanchez, L.; Hsu, A.; Olivier, K.; Zerbe, C.; Holland, S.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Calvo, K.; Rosensweig, S.] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0670
BP S448
EP S449
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100667
ER

PT J
AU Hsu, P
   Wong, N
   Avery, DT
   Torpy, J
   Gray, PE
   Fulcher, DA
   Uzel, G
   Williams, A
   Wong, M
   Campbell, DE
   Tangye, SG
AF Hsu, P.
   Wong, N.
   Avery, D. T.
   Torpy, J.
   Gray, P. E.
   Fulcher, D. A.
   Uzel, G.
   Williams, A.
   Wong, M.
   Campbell, D. E.
   Tangye, S. G.
TI Rare STAT1 GOF Mutation in Dna Binding Domain Causing Mild CMC
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Hsu, P.; Williams, A.; Wong, M.; Campbell, D. E.] Childrens Hosp Westmead, Sydney, NSW, Australia.
   [Wong, N.; Avery, D. T.; Torpy, J.; Tangye, S. G.] Garvan Inst Med Res, Immunol Res Program, Sydney, NSW, Australia.
   [Gray, P. E.] Sydney Childrens Hosp, Sydney, NSW, Australia.
   [Fulcher, D. A.] Inst Clin Pathol & Med Res, Dept Immunol & Immunopathol, Sydney, NSW, Australia.
   [Uzel, G.] NIH, Lab Clin & Infect Dis, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0149
BP S451
EP S451
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100672
ER

PT J
AU Janssen, E
   Morbach, H
   Ullas, S
   Bannock, J
   Massad, C
   Menard, L
   Barlan, I
   Lefranc, G
   Su, H
   Dasouki, M
   Al-Herz, W
   Keles, S
   Chatila, T
   Geha, R
   Meffre, E
AF Janssen, E.
   Morbach, H.
   Ullas, S.
   Bannock, J.
   Massad, C.
   Menard, L.
   Barlan, I.
   Lefranc, G.
   Su, H.
   Dasouki, M.
   Al-Herz, W.
   Keles, S.
   Chatila, T.
   Geha, R.
   Meffre, E.
TI DOCK8 Deficient Patients Have a Breakdown in Peripheral B Cell Tolerance
   and Defective Regulatory T Cells
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Janssen, E.; Ullas, S.; Chatila, T.; Geha, R.] Boston Childrens Hosp, Boston, MA USA.
   [Morbach, H.; Bannock, J.; Massad, C.; Menard, L.; Meffre, E.] Yale Univ, Sch Med, New Haven, CT USA.
   [Barlan, I.] Marmara Univ, Istanbul, Turkey.
   [Lefranc, G.] Univ Montpellier, IMGT, Lab Mol Immunogenet, F-34059 Montpellier, France.
   [Lefranc, G.] CNRS, Inst Human Genet, Montpellier, France.
   [Su, H.] NIH, Human Immunol Dis Unit, Bethesda, MD 20892 USA.
   [Dasouki, M.] Univ Kansas, Ctr Med, Kansas City, KS USA.
   [Al-Herz, W.] Kuwait Univ, Kuwait, Kuwait.
   [Keles, S.] Meram Med Fac, Konya, Turkey.
RI Su, Helen/H-9541-2015
OI Su, Helen/0000-0002-5582-9110
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0056
BP S213
EP S213
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100148
ER

PT J
AU Lugli, E
   Roberto, A
   Zanon, V
   Crocchiolo, R
   McLaren, J
   Sarina, B
   Bramanti, S
   Gandolfi, S
   Ladell, K
   Price, DA
   Roederer, M
   Castagna, L
   Mavilio, D
AF Lugli, E.
   Roberto, A.
   Zanon, V.
   Crocchiolo, R.
   McLaren, J.
   Sarina, B.
   Bramanti, S.
   Gandolfi, S.
   Ladell, K.
   Price, D. A.
   Roederer, M.
   Castagna, L.
   Mavilio, D.
TI Human Naive-Derived T Memory Stem Cells Preferentially Reconstitute the
   T Cell Immunodeficient Host
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Lugli, E.; Roberto, A.; Zanon, V.; Mavilio, D.] Humanitas Clin & Res Ctr, Rozzano, Italy.
   [Crocchiolo, R.; Sarina, B.; Bramanti, S.; Gandolfi, S.; Castagna, L.] Humanitas Clin & Res Ctr, Humanitas Canc Ctr, Rozzano, Italy.
   [McLaren, J.; Ladell, K.; Price, D. A.] Cardiff Univ, Cardiff CF10 3AX, S Glam, Wales.
   [Roederer, M.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
RI Price, David/C-7876-2013; Ladell, Kristin/C-8301-2013
OI Price, David/0000-0001-9416-2737; Ladell, Kristin/0000-0002-9856-2938
NR 0
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0341
BP S458
EP S458
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100687
ER

PT J
AU Ma, CS
   Wong, N
   Avery, DT
   Torpy, J
   Stoddard, JL
   Kobayashi, M
   Deenick, EK
   Casanova, JL
   Uzel, G
   Tangye, SG
AF Ma, C. S.
   Wong, N.
   Avery, D. T.
   Torpy, J.
   Stoddard, J. L.
   Kobayashi, M.
   Deenick, E. K.
   Casanova, J. L.
   Uzel, G.
   Tangye, S. G.
TI Determining the Molecular Requirements for Generating Human T Follicular
   Helper (Tfh) Cells
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Ma, C. S.; Wong, N.; Avery, D. T.; Torpy, J.; Deenick, E. K.; Tangye, S. G.] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia.
   [Stoddard, J. L.] NIAID, Ctr Clin, NIH, Bethesda, MD 20892 USA.
   [Kobayashi, M.] Hiroshima Univ, Grad Sch Biomed Ad Hlth Sci, Dept Pediat, Hiroshima, Japan.
   [Casanova, J. L.] Rockefeller Univ, Rockefeller Branch, Lab Human Genet Infect Dis, New York, NY 10021 USA.
   [Uzel, G.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0076
BP S458
EP S459
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100688
ER

PT J
AU Mannurita, SC
   Vignoli, M
   Colarusso, G
   Bacchetta, R
   Cecconi, M
   Tommasini, A
   Gennery, A
   Holland, SM
   Cant, AJ
   Gambineri, E
AF Mannurita, S. Ciullini
   Vignoli, M.
   Colarusso, G.
   Bacchetta, R.
   Cecconi, M.
   Tommasini, A.
   Gennery, A.
   Holland, S. M.
   Cant, A. J.
   Gambineri, E.
TI Inherited Multiple Autoimmunity: Molecular and Clinical Characterization
   of IPEX and IPEX-Like Syndromes
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Mannurita, S. Ciullini; Vignoli, M.; Colarusso, G.; Gambineri, E.] Univ Florence, Dept NEUROFARBA, Sect Childs Hlth, A Meyer Childrens Hosp, Florence, Italy.
   [Bacchetta, R.] San Raffaele Telethon Inst Gene Therapy HSR TIGET, Div Regenerat Med Stem Cells & Gene Therapy, Milan, Italy.
   [Cecconi, M.] Osped Galliera, Human Genet Labs, Genoa, Italy.
   [Tommasini, A.] IRCCS Burlo Garofalo, Paediat Immunol Lab, Trieste, Italy.
   [Gennery, A.; Cant, A. J.] Newcastle Upon Tyne Hosp, Dept Paediat Immunol, Newcastle Upon Tyne, Tyne & Wear, England.
   [Holland, S. M.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0422
BP S206
EP S206
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100133
ER

PT J
AU Martinez, B
   Holland, SM
   Uzel, G
AF Martinez, B.
   Holland, S. M.
   Uzel, G.
TI Going with the Flow: Detection of PI3K Activation in Germline PIK3CD
   Mutants
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Martinez, B.; Holland, S. M.; Uzel, G.] NIAID, Lab Clin Infect Dis, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0651
BP S362
EP S363
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100476
ER

PT J
AU Neves, J
   Zelazny, A
   Holland, S
   Cordeiro, A
   Gouveia, C
   Neves, C
   Ding, L
AF Neves, J.
   Zelazny, A.
   Holland, S.
   Cordeiro, A.
   Gouveia, C.
   Neves, C.
   Ding, L.
TI Fatal Granulibacter Bethesdensis Meningitis in XL-CGD. How Bad Is the
   Bug?
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Neves, J.; Cordeiro, A.; Gouveia, C.; Neves, C.] Hosp Dona Estefania, Lisbon, Portugal.
   [Zelazny, A.; Ding, L.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Holland, S.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0648
BP S365
EP S365
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100482
ER

PT J
AU Rissone, A
   Weinacht, K
   la Marca, G
   Bishop, K
   Giocaliere, E
   Jagadeesh, J
   Felgentreff, K
   Dobbs, K
   Al-Herz, W
   Jones, M
   Chandrasekharappa, S
   Itan, Y
   Schambach, A
   Sood, R
   Notarangelo, LD
   Candotti, F
AF Rissone, A.
   Weinacht, K.
   la Marca, G.
   Bishop, K.
   Giocaliere, E.
   Jagadeesh, J.
   Felgentreff, K.
   Dobbs, K.
   Al-Herz, W.
   Jones, M.
   Chandrasekharappa, S.
   Itan, Y.
   Schambach, A.
   Sood, R.
   Notarangelo, L. D.
   Candotti, F.
TI AK-2 Prevents From Oxidative Stress During HSC Development and
   Hematopoietic Differentiation
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Rissone, A.; Jagadeesh, J.; Candotti, F.] NHGRI, GMBB, Bethesda, MD 20892 USA.
   [Weinacht, K.] Boston Childrens Hosp, Div Hematol Oncol, Boston, MA USA.
   [la Marca, G.] Univ Florence, Dept Neurosci Psychol Pharmacol & Child Hlth, Florence, Italy.
   [Bishop, K.; Sood, R.] NHGRI, Zebrafish Core, Bethesda, MD 20892 USA.
   [Giocaliere, E.] Meyer Childrens Univ Hosp, Univ Hosp, Florence, Italy.
   [Felgentreff, K.; Dobbs, K.; Notarangelo, L. D.] Boston Childrens Hosp, Div Immunol, Boston, MA USA.
   [Al-Herz, W.] Kuwait Univ, Fac Med, Dept Pediat, Kuwait, Kuwait.
   [Jones, M.; Chandrasekharappa, S.] NHGRI, Genom Core, Bethesda, MD 20892 USA.
   [Itan, Y.] Rockefeller Univ, St Giles Lab Human Genet Infect Dis, New York, NY 10021 USA.
   [Schambach, A.] Hannover Med Sch, Inst Expt Hematol, Hannover, Germany.
RI Notarangelo, Luigi/F-9718-2016
OI Notarangelo, Luigi/0000-0002-8335-0262
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0557
BP S383
EP S384
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100525
ER

PT J
AU Sarracino, DC
   Shaw, K
   Sokolic, R
   Davila, A
   Garabedian, E
   Silvin, C
   Barman, P
   de Oliveira, S
   Jin, X
   Geiger, S
   Smogorzewska, M
   Jagadeesh, J
   Crooks, G
   Moore, T
   Wayne, A
   Hershfield, M
   Gaspar, B
   Thrasher, A
   Candotti, F
   Kohn, D
AF Sarracino, D. Carbonaro
   Shaw, K.
   Sokolic, R.
   Davila, A.
   Garabedian, E.
   Silvin, C.
   Barman, P.
   de Oliveira, S.
   Jin, X.
   Geiger, S.
   Smogorzewska, M.
   Jagadeesh, J.
   Crooks, G.
   Moore, T.
   Wayne, A.
   Hershfield, M.
   Gaspar, B.
   Thrasher, A.
   Candotti, F.
   Kohn, D.
TI US Clinical Gene Therapy Trials for Adenosine Deaminase-Deficient Severe
   Combined Immune Deficiency (ADA-SCID)
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Sarracino, D. Carbonaro; Shaw, K.; Davila, A.; Barman, P.; de Oliveira, S.; Jin, X.; Geiger, S.; Crooks, G.; Moore, T.; Kohn, D.] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Sokolic, R.; Garabedian, E.; Silvin, C.; Jagadeesh, J.; Candotti, F.] NHGRI, Genet & Mol Biol Branch, Bethesda, MD 20892 USA.
   [Smogorzewska, M.] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
   [Wayne, A.] NHGRI, Hematol Dis Sect, Pediat Oncol Branch, Bethesda, MD 20892 USA.
   [Hershfield, M.] Duke Univ, Sch Med, Durham, NC 27706 USA.
   [Gaspar, B.; Thrasher, A.] UCL, Inst Child Hlth, London, England.
RI De Oliveira, Satiro/D-8860-2014
OI De Oliveira, Satiro/0000-0002-8181-7316
NR 0
TC 2
Z9 2
U1 1
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0687
BP S313
EP S313
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100373
ER

PT J
AU Sassi, A
   Fliegauf, M
   Yang, L
   Wu, G
   Haslam, SM
   Mellouli, F
   Patiroglu, T
   Unal, E
   Ozdemir, MA
   Jouhadi, Z
   Khadir, K
   Ben-Khemis, L
   Ben-Ali, M
   Ben-Mustapha, I
   Borchani, L
   Khemiri, M
   Maul-Pavicic, A
   Rakhmanov, M
   Henneke, P
   Kraus, H
   Eibel, H
   Kolsch, U
   Nadifi, S
   Nilsson, M
   Bejaoui, M
   Schaffer, AA
   Smith, CIE
   Dell, A
   Barbouche, MR
   Grimbacher, B
AF Sassi, A.
   Fliegauf, M.
   Yang, L.
   Wu, G.
   Haslam, S. M.
   Mellouli, F.
   Patiroglu, T.
   Unal, E.
   Ozdemir, M. A.
   Jouhadi, Z.
   Khadir, K.
   Ben-Khemis, L.
   Ben-Ali, M.
   Ben-Mustapha, I.
   Borchani, L.
   Khemiri, M.
   Maul-Pavicic, A.
   Rakhmanov, M.
   Henneke, P.
   Kraus, H.
   Eibel, H.
   Koelsch, U.
   Nadifi, S.
   Nilsson, M.
   Bejaoui, M.
   Schaeffer, A. A.
   Smith, C. I. E.
   Dell, A.
   Barbouche, M. R.
   Grimbacher, B.
TI Hypomorphic Homozygous Mutations in Phosphoglucomutase3 Impair Immunity
   and Increase Serum IGE Levels
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Sassi, A.; Ben-Khemis, L.; Ben-Ali, M.; Ben-Mustapha, I.; Barbouche, M. R.] Inst Pasteur, Tunis, Tunisia.
   [Sassi, A.; Ben-Khemis, L.; Ben-Ali, M.; Ben-Mustapha, I.; Barbouche, M. R.] Univ Tunis El Manar, Tunis, Tunisia.
   [Fliegauf, M.; Yang, L.; Maul-Pavicic, A.; Rakhmanov, M.; Henneke, P.; Kraus, H.; Eibel, H.; Grimbacher, B.] Univ Med Ctr Freiburg, CCI, Freiburg, Germany.
   [Wu, G.; Haslam, S. M.; Dell, A.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London, England.
   [Mellouli, F.; Bejaoui, M.] Bone Marrow Transplantat Ctr, Pediat Dept, Tunis, Tunisia.
   [Patiroglu, T.; Unal, E.; Ozdemir, M. A.] Erciyes Univ, Fac Med, Div Pediat Hematol & Oncol, Kayseri, Turkey.
   [Jouhadi, Z.; Khadir, K.] CHU IBN ROCHD Hassan II Univ, Dept Pediat Infect Dis, Casablanca, Morocco.
   [Borchani, L.] Inst Pasteur, Lab Venoms & Therapeut Mol, Tunis, Tunisia.
   [Khemiri, M.] Childrens Hosp, Pediat Dept A, Tunis, Tunisia.
   [Koelsch, U.] Charite & Campus Virchow Klinikum, Lab Berlin, Berlin, Germany.
   [Koelsch, U.] Charite & Campus Virchow Klinikum, Inst Med Immunol, Berlin, Germany.
   [Nadifi, S.] Hassan II Univ, Dept Genet, Casablanca, Morocco.
   [Nilsson, M.] Uppsala Univ, Rudbeck Lab, Dept Immunol, Uppsala, Sweden.
   [Schaeffer, A. A.] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA.
   [Smith, C. I. E.] Karolinska Univ Hosp Huddinge, Clin Res Ctr, Huddinge, Sweden.
   [Smith, C. I. E.] Karolinska Univ Hosp Huddinge, Dept Lab Med 34, Huddinge, Sweden.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0539
BP S161
EP S162
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100039
ER

PT J
AU Schena, F
   Volpi, S
   Caorsi, R
   Omenetti, A
   Pastorino, C
   Picco, P
   Aksentijevich, I
   Martini, A
   Traggiai, E
   Gattorno, M
AF Schena, F.
   Volpi, S.
   Caorsi, R.
   Omenetti, A.
   Pastorino, C.
   Picco, P.
   Aksentijevich, I.
   Martini, A.
   Traggiai, E.
   Gattorno, M.
TI B Cell Characterization in ADA2 Deficiency Patients
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Schena, F.; Caorsi, R.; Pastorino, C.; Picco, P.; Martini, A.; Gattorno, M.] G Gaslini Inst Children, Pediat Div 2, Genoa, Italy.
   [Volpi, S.; Omenetti, A.] Univ Genoa, DINOGMI, Genoa, Italy.
   [Aksentijevich, I.] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Traggiai, E.] Novartis Inst Res Biomed, Cell & Antibody Discovery Lab B, Basel, Switzerland.
RI Caorsi, Roberta/K-8608-2016
OI Caorsi, Roberta/0000-0003-0131-7846
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0460
BP S420
EP S421
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100608
ER

PT J
AU Schubert, D
   Bode, C
   Kenefeck, R
   Hou, TZ
   Wing, J
   Unger, S
   Bulashevska, A
   Gruning, BA
   Petersen, BS
   Schaffer, AA
   Frede, N
   Dueckers, G
   Seneviratne, S
   Kanariou, M
   Rensing-Ehl, A
   Salzer, U
   Warnatz, K
   Emmerich, F
   Cathomen, T
   Fisch, P
   Rakhmanov, M
   Franke, A
   Sakaguchi, S
   Walker, LSK
   Sansom, DM
   Grimbacher, B
AF Schubert, D.
   Bode, C.
   Kenefeck, R.
   Hou, T. Z.
   Wing, J.
   Unger, S.
   Bulashevska, A.
   Gruening, B. A.
   Petersen, B. S.
   Schaeffer, A. A.
   Frede, N.
   Dueckers, G.
   Seneviratne, S.
   Kanariou, M.
   Rensing-Ehl, A.
   Salzer, U.
   Warnatz, K.
   Emmerich, F.
   Cathomen, T.
   Fisch, P.
   Rakhmanov, M.
   Franke, A.
   Sakaguchi, S.
   Walker, L. S. K.
   Sansom, D. M.
   Grimbacher, B.
TI CTLA-4 Deficiency - A Novel Autosomal-Dominant Immune Dysregulation
   Syndrome
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Schubert, D.; Bode, C.; Unger, S.; Bulashevska, A.; Frede, N.; Rensing-Ehl, A.; Salzer, U.; Warnatz, K.; Rakhmanov, M.; Grimbacher, B.] Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany.
   [Kenefeck, R.; Hou, T. Z.; Seneviratne, S.; Walker, L. S. K.; Sansom, D. M.] UCL Inst Immun & Transplantat, London, England.
   [Wing, J.; Sakaguchi, S.] Osaka Univ, Dept Expt Immunol, Osaka, Japan.
   [Gruening, B. A.] Univ Freiburg, Dept Comp Sci, D-79106 Freiburg, Germany.
   [Petersen, B. S.; Franke, A.] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
   [Schaeffer, A. A.] NIH, Natl Lib Med, Bethesda, MD 20892 USA.
   [Dueckers, G.] HELIOS Kliniken Krefeld, Krefeld, Germany.
   [Kanariou, M.] Aghia Sophia Childrens Hosp, Dept Immunol & Histocompatibil, Athens, Greece.
   [Emmerich, F.; Cathomen, T.] Univ Med Ctr Freiburg, Inst Cell & Gene Therapy, Freiburg, Germany.
   [Fisch, P.] Univ Med Ctr Freiburg, Dept Pathol, Freiburg, Germany.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0360
BP S144
EP S144
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100010
ER

PT J
AU Schwartzberg, P
   Cannons, J
   Zhao, P
   Reilley, J
   Kapnick, S
   Tangye, S
   Uzel, G
AF Schwartzberg, P.
   Cannons, J.
   Zhao, P.
   Reilley, J.
   Kapnick, S.
   Tangye, S.
   Uzel, G.
TI Defects in CD8 Cytolysis in Immunodeficiencies with Impaired EBV
   Clearance
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Schwartzberg, P.; Cannons, J.; Zhao, P.; Reilley, J.; Kapnick, S.] NHGRI, Genet Dis Res Branch, Bethesda, MD 20892 USA.
   [Tangye, S.] Garvan Inst, Sydney, NSW, Australia.
   [Uzel, G.] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0853
BP S491
EP S492
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100757
ER

PT J
AU Sokolic, R
   Nghiem, K
   Oden, N
   Garabedian, E
   Lozier, J
   Candotti, F
AF Sokolic, R.
   Nghiem, K.
   Oden, N.
   Garabedian, E.
   Lozier, J.
   Candotti, F.
TI New Notions on Platelet Biology in Wiskott-Aldrich Syndrome (WAS)
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Sokolic, R.; Candotti, F.] NIH, Disorders Immun Sect, Bethesda, MD 20892 USA.
   [Nghiem, K.; Lozier, J.] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
   [Oden, N.] EMMES Corp, Dept Stat, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0637
BP S374
EP S375
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100504
ER

PT J
AU Sokolic, R
   Koh, C
   Komarow, H
   Garabedian, E
   Silvin, C
   Cowen, E
   Hadigan, C
   Heller, T
   Kleiner, D
   Metcalfe, D
   Hershfield, M
   Candotti, F
AF Sokolic, R.
   Koh, C.
   Komarow, H.
   Garabedian, E.
   Silvin, C.
   Cowen, E.
   Hadigan, C.
   Heller, T.
   Kleiner, D.
   Metcalfe, D.
   Hershfield, M.
   Candotti, F.
TI The Expanding Clinical Phenotype of Adenosine Deaminase (ADA) Deficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Sokolic, R.; Garabedian, E.; Silvin, C.; Candotti, F.] NHGRI, GMBB, Bethesda, MD 20892 USA.
   [Koh, C.; Heller, T.] NIDDK, LDB, Bethesda, MD 20892 USA.
   [Komarow, H.; Metcalfe, D.] NIAID, LAD, Bethesda, MD 20892 USA.
   [Cowen, E.] NCI, DB, Bethesda, MD 20892 USA.
   [Hadigan, C.] NIAID, CRS, Bethesda, MD 20892 USA.
   [Kleiner, D.] NCI, LP, Bethesda, MD 20892 USA.
   [Hershfield, M.] Duke Univ, Sch Med, Durham, NC 27706 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0780
BP S329
EP S329
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100402
ER

PT J
AU Su, H
   Zhang, Q
   Dove, C
   Hor, J
   Murdock, H
   Strauss-Albee, D
   Garcia, J
   Mandl, J
   Grodick, R
   Jing, H
   Chandler-Brown, D
   Kim, E
   Lenardo, T
   Crawford, G
   Matthews, H
   Freeman, A
   Cornall, R
   Germain, R
   Mueller, S
AF Su, H.
   Zhang, Q.
   Dove, C.
   Hor, J.
   Murdock, H.
   Strauss-Albee, D.
   Garcia, J.
   Mandl, J.
   Grodick, R.
   Jing, H.
   Chandler-Brown, D.
   Kim, E.
   Lenardo, T.
   Crawford, G.
   Matthews, H.
   Freeman, A.
   Cornall, R.
   Germain, R.
   Mueller, S.
TI DOCK8 Regulates Lymphocyte Shape Integrity for Skin Antiviral Immunity
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Su, H.; Zhang, Q.; Dove, C.; Murdock, H.; Strauss-Albee, D.; Garcia, J.; Grodick, R.; Jing, H.; Chandler-Brown, D.; Kim, E.; Lenardo, T.] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA.
   [Hor, J.; Mueller, S.] Univ Melbourne, Parkville, Vic 3052, Australia.
   [Mandl, J.; Germain, R.] NIAID, Lab Syst Biol, NIH, Bethesda, MD 20892 USA.
   [Crawford, G.; Cornall, R.] Univ Oxford, Nuffield Dept Med, Oxford, England.
   [Matthews, H.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   [Freeman, A.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA.
RI Su, Helen/H-9541-2015
OI Su, Helen/0000-0002-5582-9110
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0734
BP S471
EP S472
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100719
ER

PT J
AU Ten Bosch, JV
   Rao, VK
   Maric, I
   De Waele, M
   De Raeve, H
AF Ten Bosch, J. Van Der Werff
   Rao, V. K.
   Maric, I.
   De Waele, M.
   De Raeve, H.
TI Intramedullar Lymphoproliferation in a Young Adult with Autoimmune
   Lymphoproliferative Syndrome
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Ten Bosch, J. Van Der Werff] UZ Brussel, Pediat, Brussels, Belgium.
   [Rao, V. K.] NIAID, Mol Dev Sect, Immunol Lab, Div Intramural Res,NIH, Bethesda, MD 20892 USA.
   [Maric, I.] NIH, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA.
   [De Waele, M.] UZ Brussel, Dept Lab Haematol, Brussels, Belgium.
   [De Raeve, H.] UZ Brussel, Dept Anatomopathol, Brussels, Belgium.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0718
BP S230
EP S230
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100187
ER

PT J
AU Tesi, B
   Sieni, E
   Neves, C
   Romano, F
   Cordeiro, AI
   Canessa, C
   Chiang, S
   Cetica, V
   Schlums, H
   Henter, JI
   Nordenskjold, M
   Hsu, AP
   Holland, SM
   Bryceson, YT
   Neves, JF
   Azzari, C
AF Tesi, B.
   Sieni, E.
   Neves, C.
   Romano, F.
   Cordeiro, A. I.
   Canessa, C.
   Chiang, S.
   Cetica, V.
   Schlums, H.
   Henter, J. I.
   Nordenskjold, M.
   Hsu, A. P.
   Holland, S. M.
   Bryceson, Y. T.
   Neves, J. F.
   Azzari, C.
TI Hemophagocytic Lymphohistiocytosis in Two Patients with Interferon-Gamma
   Receptor Deficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Tesi, B.; Henter, J. I.] Karolinska Inst, Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.
   [Sieni, E.; Cetica, V.] Meyer Childrens Univ Hosp, Dept Pediat Hematol Oncol, Florence, Italy.
   [Neves, C.; Cordeiro, A. I.; Neves, J. F.] Ctr Hosp Lisboa Cent, Hosp Dona Estefania, Primary Immunodeficiencies Unit, Lisbon, Portugal.
   [Romano, F.; Canessa, C.; Azzari, C.] Univ Florence, Dept Hlth Sci, Div Pediat Immunol, Jeffrey Modell Ctr Primary,Anna Meyer Childrens H, Florence, Italy.
   [Chiang, S.; Schlums, H.; Bryceson, Y. T.] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Ctr Infect Med, Stockholm, Sweden.
   [Nordenskjold, M.] Karolinska Inst, Karolinska Univ Hosp, Clin Genet Unit, Dept Mol Med & Surg, Stockholm, Sweden.
   [Nordenskjold, M.] Karolinska Inst, Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.
   [Hsu, A. P.; Holland, S. M.] NIAID, NIH, Bethesda, MD 20892 USA.
RI chiang, samuel/M-9267-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0575
BP S273
EP S274
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100285
ER

PT J
AU Uzel, G
   Stoddard, J
   Martinez, B
   Agharahimi, A
   Hussey, AA
   Folio, LR
   Pittaluga, S
   Fleisher, TA
   Tangye, SG
   Holland, SM
AF Uzel, G.
   Stoddard, J.
   Martinez, B.
   Agharahimi, A.
   Hussey, A. A.
   Folio, L. R.
   Pittaluga, S.
   Fleisher, T. A.
   Tangye, S. G.
   Holland, S. M.
TI A Short-Term Treatment Summary Using M-TOR Inhibitors in Patients with
   Germline PIK3CD Mutations: Prospects for Future
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Uzel, G.; Stoddard, J.; Martinez, B.; Agharahimi, A.; Hussey, A. A.; Fleisher, T. A.; Holland, S. M.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Folio, L. R.] NIH, Ctr Clin, Bethesda, MD 20892 USA.
   [Pittaluga, S.] NCI, NIH, Bethesda, MD 20892 USA.
   [Tangye, S. G.] Garvan Inst Med Res, Dept Immunol, Sydney, NSW, Australia.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0685
BP S164
EP S164
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100044
ER

PT J
AU Uzel, G
   Kuehn, HS
   Weiming, Q
   Lo, B
   Deenick, EK
   Niemela, JE
   Avery, DT
   Schickel, JN
   Tran, DQ
   Stoddard, J
   Zhang, Y
   Frucht, DM
   Rao, KV
   Su, HC
   Notarangelo, LD
   Olivier, KN
   McElwee, J
   Pittaluga, S
   Oliveira, JB
   Meffre, E
   Fleisher, TA
   Holland, SM
   Tangye, SG
   Lenardo, MJ
AF Uzel, G.
   Kuehn, H. S.
   Weiming, Q.
   Lo, B.
   Deenick, E. K.
   Niemela, J. E.
   Avery, D. T.
   Schickel, J. N.
   Tran, D. Q.
   Stoddard, J.
   Zhang, Y.
   Frucht, D. M.
   Rao, K. V.
   Su, H. C.
   Notarangelo, L. D.
   Olivier, K. N.
   McElwee, J.
   Pittaluga, S.
   Oliveira, J. B.
   Meffre, E.
   Fleisher, T. A.
   Holland, S. M.
   Tangye, S. G.
   Lenardo, M. J.
TI Human CTLA4 Haploinsufficiency Causes Severe Immune Dysregulation
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Uzel, G.; Lo, B.; Zhang, Y.; Rao, K. V.; Su, H. C.; Olivier, K. N.; Holland, S. M.; Lenardo, M. J.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Kuehn, H. S.; Niemela, J. E.; Stoddard, J.; Fleisher, T. A.] NIH, CC, Bethesda, MD 20892 USA.
   [Weiming, Q.; Frucht, D. M.] US FDA, CDER, Bethesda, MD 20014 USA.
   [Deenick, E. K.; Avery, D. T.; Tangye, S. G.] Garvan Inst Med Res, Immunol Dept, Sydney, NSW, Australia.
   [Schickel, J. N.; Meffre, E.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT USA.
   [Tran, D. Q.] Univ Texas Houston, Sch Med, Dept Pediat, Houston, TX USA.
   [Notarangelo, L. D.] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA.
   [McElwee, J.] Merck & Co Inc, Merck Res Labs, Boston, MA USA.
   [Pittaluga, S.] NCI, NIH, Boston, MA USA.
   [Oliveira, J. B.] Inst Med Integral Prof Fernando Figueira, IMIP, Recife, PE, Brazil.
RI Notarangelo, Luigi/F-9718-2016
OI Notarangelo, Luigi/0000-0002-8335-0262
NR 0
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0767
BP S144
EP S145
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100011
ER

PT J
AU van Montfrans, J
   van Royen-Kerkhof, A
   Bierings, M
   Aksentijevich, I
   Zavialov, A
   Zhou, Q
AF van Montfrans, J.
   van Royen-Kerkhof, A.
   Bierings, M.
   Aksentijevich, I.
   Zavialov, A.
   Zhou, Q.
TI Hematological Stem Cell Transplantation in ADA2 Deficiency
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [van Montfrans, J.; van Royen-Kerkhof, A.; Bierings, M.] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Aksentijevich, I.; Zhou, Q.] NHGRI, Inflammatory Dis Sect, NIH, Bethesda, MD 20892 USA.
   [Zavialov, A.] Univ Turku, Turku Ctr Biotechnol, Turku, Finland.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0444
BP S230
EP S231
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100188
ER

PT J
AU Volk, T
   Reisli, I
   Bjorkman, A
   Pannicke, U
   Fisch, P
   Schaffer, AA
   Bulashevska, A
   Gruning, BA
   Pfeifer, D
   Guner, S
   Sayar, EH
   Hammarstrom, L
   Durandy, A
   Salzer, U
   Pan-Hammarstrom, Q
   Rizzi, M
   Schwarz, K
   Grimbacher, B
AF Volk, T.
   Reisli, I.
   Bjorkman, A.
   Pannicke, U.
   Fisch, P.
   Schaeffer, A. A.
   Bulashevska, A.
   Gruening, B. A.
   Pfeifer, D.
   Guner, S.
   Sayar, E. H.
   Hammarstrom, L.
   Durandy, A.
   Salzer, U.
   Pan-Hammarstrom, Q.
   Rizzi, M.
   Schwarz, K.
   Grimbacher, B.
TI Autosomal-Recessive Agammaglobulinemia Due to Homozygous Mutations in
   Artemis: Do We Need a Modifier?
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Volk, T.; Bulashevska, A.; Salzer, U.; Rizzi, M.; Grimbacher, B.] Univ Med Ctr Freiburg, Freiburg, Germany.
   [Volk, T.; Bulashevska, A.; Salzer, U.; Rizzi, M.; Grimbacher, B.] Univ Freiburg, CCI, D-79106 Freiburg, Germany.
   [Reisli, I.; Guner, S.; Sayar, E. H.] Necmettin Erbakan Univ, Meram Med Fac, Dept Pediat Immunol & Allergy, Konya, Turkey.
   [Bjorkman, A.; Pan-Hammarstrom, Q.] Karolinska Inst, Dept Lab Med, S-17177 Stockholm, Sweden.
   [Pannicke, U.; Schwarz, K.] Univ Ulm, Inst Transfus Med, D-89069 Ulm, Germany.
   [Fisch, P.] Univ Freiburg, Ctr Pathol, Med Ctr, D-79106 Freiburg, Germany.
   [Schaeffer, A. A.] NIH, Dept Hlth & Human Serv, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
   [Gruening, B. A.] Univ Freiburg, Bioinformat Grp, Dept Comp Sci, D-79106 Freiburg, Germany.
   [Pfeifer, D.] Univ Med Ctr, Dept Hematol & Oncol, Freiburg, Germany.
   [Hammarstrom, L.] Karolinska Univ Hosp, Dept Clin Immunol & Transfus Med, Stockholm, Sweden.
   [Durandy, A.] Univ Paris 05, INSERM, U768, Paris, France.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0451
BP S146
EP S147
PG 2
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100015
ER

PT J
AU Walkovich, K
   Kuhns, DB
   Priel, DAL
   Holland, SM
   Uzel, G
AF Walkovich, K.
   Kuhns, D. B.
   Priel, D. A. Long
   Holland, S. M.
   Uzel, G.
TI The Extended Spectrum of Leukocyte Adhesion Deficiency-1: Single
   Institution Long Term Follow-Up of 12 Cases
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies
CY OCT 29-NOV 01, 2014
CL Prague, CZECH REPUBLIC
SP European Soc Immunodeficiencies
C1 [Walkovich, K.] Univ Michigan, CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA.
   [Kuhns, D. B.; Priel, D. A. Long] Clinical Serv Program Leidos Biomed Res Inc, Fredrick Natl Lab Canc Res, Frederick, MD USA.
   [Holland, S. M.; Uzel, G.] NIAID, NIH, Lab Clin Infect Dis, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD OCT
PY 2014
VL 34
SU 2
MA ESID-0571
BP S152
EP S152
PG 1
WC Immunology
SC Immunology
GA AY1ZS
UT WOS:000347389100023
ER

PT J
AU Siebert, M
   Westbroek, W
   Chen, YC
   Moaven, N
   Li, Y
   Velayati, A
   Saraiva-Pereira, ML
   Martin, SE
   Sidransky, E
AF Siebert, Marina
   Westbroek, Wendy
   Chen, Yu-Chi
   Moaven, Nima
   Li, Yan
   Velayati, Arash
   Saraiva-Pereira, Maria Luiza
   Martin, Scott E.
   Sidransky, Ellen
TI Identification of miRNAs that modulate glucocerebrosidase activity in
   Gaucher disease cells
SO RNA BIOLOGY
LA English
DT Article
DE Gaucher Disease; GBA; GCase; glucocerebrosidase; mimics; miRNA; screen
ID MICRORNAS; GENE; EXPRESSION; DISORDER; MUTATION; TARGETS; RNA
AB Gaucher disease is an autosomal recessive disorder caused by deficiency of the enzyme glucocerebrosidase. Although it is a monogenic disease, there is vast phenotypic heterogeneity, even among patients with the same genotype. MicroRNAs (miRNAs) are small non-coding RNAs involved in many biological processes and diseases. To determine whether miRNAs can affect glucocerebrosidase activity, we performed a screen of 875 different miRNA mimics. The screen was performed using Gaucher fibroblasts, and glucocerebrosidase activity was used as the initial outcome parameter. We found several miRNAs that either up- or down-regulated glucocerebrosidase activity. In follow-up assays, we confirmed that one specific miRNA (miR-127-5p) down-regulated both glucocerebrosidase activity and protein levels by down-regulation of LIMP-2, the receptor involved in proper trafficking of glucocerebrosidase from the endoplasmic reticulum to the lysosome. A conditioned media assay demonstrated that cells treated with this miRNA secreted glucocerebrosidase into the extracellular environment, supporting impaired LIMP-2 function. Two other miRNAs, miR-16-5p and miR-195-5p, were found to up-regulate glucocerebrosidase activity by greater than 40% and to enhance expression and protein levels of the enzyme. In conclusion, we show that miRNAs can alter glucocerebrosidase activity in patient cells, indicating that miRNAs can potentially act as modifiers in Gaucher disease.
C1 [Siebert, Marina; Westbroek, Wendy; Moaven, Nima; Velayati, Arash; Sidransky, Ellen] NHGRI, Sect Mol Neurogenet, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Siebert, Marina; Saraiva-Pereira, Maria Luiza] Univ Fed Rio Grande do Sul, Postgrad Program Cellular & Mol Biol, Porto Alegre, RS, Brazil.
   [Siebert, Marina; Saraiva-Pereira, Maria Luiza] Hosp Clin Porto Alegre, Lab Genet Identificat, Porto Alegre, RS, Brazil.
   [Siebert, Marina; Saraiva-Pereira, Maria Luiza] Hosp Clin Porto Alegre, Gen Med Serv, Porto Alegre, RS, Brazil.
   [Chen, Yu-Chi; Martin, Scott E.] NIH, RNAi Screening Facil, Natl Ctr Adv Translat Sci, Rockville, MD 20852 USA.
   [Li, Yan] NINDS, Prot Peptide Sequencing Facil, NIH, Bethesda, MD 20892 USA.
   [Saraiva-Pereira, Maria Luiza] Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, RS, Brazil.
RP Martin, SE (reprint author), NIH, RNAi Screening Facil, Natl Ctr Adv Translat Sci, Rockville, MD 20852 USA.
EM martinsc@mail.nih.gov; sidranse@nih.gov
RI Saraiva-Pereira, Maria Luiza/H-6302-2013
OI Saraiva-Pereira, Maria Luiza/0000-0003-3905-9563
FU Intramural Research Programs of National Human Genome Research
   Institute; RNAi Screening Facility of National Center for Advancing
   Translational Sciences; National Institutes of Health; Brazilian Federal
   Agency for Support and Evaluation of Graduate Education - CAPES;
   Fulbright Brazil
FX This work was supported by the Intramural Research Programs of National
   Human Genome Research Institute, RNAi Screening Facility of National
   Center for Advancing Translational Sciences, and National Institutes of
   Health. M.S. received support from the Brazilian Federal Agency for
   Support and Evaluation of Graduate Education - CAPES and Fulbright
   Brazil.
NR 30
TC 6
Z9 6
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1547-6286
EI 1555-8584
J9 RNA BIOL
JI RNA Biol.
PD OCT
PY 2014
VL 11
IS 10
BP 1291
EP 1300
DI 10.1080/15476286.2014.996085
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CB1CP
UT WOS:000349364600010
PM 25584808
ER

PT J
AU Robbins, HA
   Waterboer, T
   Porras, C
   Kemp, TJ
   Pawlita, M
   Rodriguez, AC
   Wacholder, S
   Gonzalez, P
   Schiller, JT
   Lowy, DR
   Esser, M
   Matys, K
   Poncelet, S
   Herrero, R
   Hildesheim, A
   Pinto, LA
   Safaeian, M
AF Robbins, Hilary A.
   Waterboer, Tim
   Porras, Carolina
   Kemp, Troy J.
   Pawlita, Michael
   Cecilia Rodriguez, Ana
   Wacholder, Sholom
   Gonzalez, Paula
   Schiller, John T.
   Lowy, Douglas R.
   Esser, Mark
   Matys, Katie
   Poncelet, Sylviane
   Herrero, Rolando
   Hildesheim, Allan
   Pinto, Ligia A.
   Safaeian, Mahboobeh
TI Immunogenicity assessment of HPV16/18 vaccine using the glutathione
   S-transferase L1 multiplex serology assay
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article
DE cLIA; GST-L1 multiplex serology; HPV vaccine; human papillomavirus
   (HPV); immunogenicity assessment; SEAP-NA; VLP-ELISA; BKV; BK virus;
   cLIA; competitive Luminex immunoassay; CV; coefficient of variation;
   CVT; Costa Rica Vaccine Trial; EU; mL; ELISA units per milliliter;
   GST-L1; glutathione S-transferase L1 multiplex serology assay; HPV;
   human papillomavirus; ICC; intraclass correlation coefficient; JCV; JC
   virus; LLOD; lower limit of detection; MFI; median fluorescence units;
   mMU; mL; milli-Merck units per milliliter; OD; optical density; SEAP-NA;
   secreted alkaline phosphatase neutralization assay; VLP; virus-like
   particle; VLP-ELISA; virus-like particle-based enzyme linked
   immunosorbent assay
ID HUMAN-PAPILLOMAVIRUS TYPES; VIRUS-LIKE PARTICLES; HPV-16/18
   AS04-ADJUVANTED VACCINE; COSTA-RICA; NEUTRALIZING EPITOPES;
   ANTIBODY-RESPONSES; TRIAL; EFFICACY; IMMUNIZATION; TYPE-18
AB The glutathione S-transferase (GST)-L1 multiplex serology assay has favorable properties for use in clinical trials and epidemiologic studies, including low cost, high throughput capacity, and low serum volume requirement. Therefore, we evaluated the GST-L1 assay as a measure of HPV16/18 vaccine immunogenicity. Our study population included 65 women selected from the Costa Rica Vaccine Trial who received the bivalent HPV16/18 virus-like particle (VLP) vaccine at the recommended 0/1/6-month schedule. We tested replicate serum samples from months 0/1/12 (i.e., after 0/1/3 doses) by GST-L1 and 3 other commonly used serology assays, VLP-ELISA, SEAP-NA, and cLIA. We calculated the percentage of women seropositive by GST-L1 by time point and HPV type (14 HPV types), and compared GST-L1 to other assays using Spearman rank correlation coefficients. After 1 vaccine dose, seropositivity by GST-L1 was 40% each for HPV16 and HPV18, increasing to 100% and 98%, respectively, after 3 doses. Seropositivity after 3 doses ranged from 32% to 69% for HPV types 31/33/45, for which partial vaccine efficacy is reported, though increases also occurred for types with no evidence for cross-protection (e.g., HPV77). GST-L1 correlated best after 3 doses with VLP-ELISA (HPV16 and HPV18 each = 0.72) and SEAP-NA (HPV16 = 0.65, HPV18 = 0.71) (all P<0.001); correlation was lower with cLIA. The GST-L1 is suitable for evaluating HPV16/18 vaccine immunogenicity after 3 vaccine doses, although in contrast to other assays it may classify some samples as HPV16/18 seronegative. The assay's utility is limited for lower antibody levels such as after receipt of 1 dose.
C1 [Robbins, Hilary A.; Wacholder, Sholom; Hildesheim, Allan; Safaeian, Mahboobeh] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA.
   [Waterboer, Tim; Pawlita, Michael] German Canc Res Ctr, Heidelberg, Germany.
   [Porras, Carolina; Cecilia Rodriguez, Ana; Gonzalez, Paula; Herrero, Rolando] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, Guanacaste, Costa Rica.
   [Kemp, Troy J.; Pinto, Ligia A.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, HPV Immunol Lab, Frederick, MD USA.
   [Gonzalez, Paula; Herrero, Rolando] Int Agcy Res Canc, F-69372 Lyon, France.
   [Schiller, John T.; Lowy, Douglas R.] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Matys, Katie] PPD Vaccines & Biol Ctr Excellence, Wayne, PA USA.
   [Poncelet, Sylviane] GlaxoSmithKline Biol, Rixensart, Belgium.
RP Robbins, HA (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA.
EM hilary.robbins@alumni.duke.edu
RI Hildesheim, Allan/B-9760-2015; Waterboer, Tim/G-1252-2010; 
OI Hildesheim, Allan/0000-0003-0257-2363; Pawlita,
   Michael/0000-0002-4720-8306
FU NCI [N01-CP-11005]; National Institutes of Health Office of Research on
   Women's Health; Ministry of Health of Costa Rica; GlaxoSmithKline
FX The Costa Rica HPV Vaccine Trial is a long-standing collaboration
   between investigators in Costa Rica and the National Cancer Institute
   (NCI). The trial is sponsored and funded by the NCI (contract
   N01-CP-11005), with funding support from the National Institutes of
   Health Office of Research on Women's Health, and done with the support
   from the Ministry of Health of Costa Rica. Vaccine was provided for our
   trial by GlaxoSmithKline Biologicals, under a Clinical Trials Agreement
   with the NCI. GlaxoSmithKline also provided support for aspects of the
   trial associated with regulatory submission needs of the company under
   US Food and Drug Administration BB-IND 7920.
NR 37
TC 0
Z9 0
U1 2
U2 4
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD OCT
PY 2014
VL 10
IS 10
BP 2965
EP 2974
DI 10.4161/21645515.2014.972811
PG 10
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA AZ6FX
UT WOS:000348315500033
PM 25483632
ER

PT J
AU Lowe, JM
   Menendez, D
   Fessler, MB
AF Lowe, Julie M.
   Menendez, Daniel
   Fessler, Michael B.
TI A new inflammatory role for p53 in human macrophages
SO CELL CYCLE
LA English
DT Editorial Material
C1 [Lowe, Julie M.; Fessler, Michael B.] NIEHS, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA.
   [Menendez, Daniel] NIEHS, Lab Mol Genet, NIH, Res Triangle Pk, NC 27709 USA.
RP Lowe, JM (reprint author), NIEHS, Lab Resp Biol, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM julie.lowe@nih.gov; fesslerm@niehs.nih.gov
NR 5
TC 0
Z9 0
U1 1
U2 2
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD OCT 1
PY 2014
VL 13
IS 19
BP 2983
EP 2984
DI 10.4161/15384101.2014.959852
PG 2
WC Cell Biology
SC Cell Biology
GA AZ6JQ
UT WOS:000348326600001
PM 25486553
ER

PT J
AU Albert, PS
   Grantz, KL
AF Albert, Paul S.
   Grantz, Katherine L.
TI Fetal growth and ethnic Variation
SO LANCET DIABETES & ENDOCRINOLOGY
LA English
DT Letter
C1 [Albert, Paul S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA.
   [Grantz, Katherine L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, Bethesda, MD USA.
RP Albert, PS (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA.
EM albertp@mail.nih.gov
OI Grantz, Katherine/0000-0003-0276-8534
NR 1
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2213-8587
J9 LANCET DIABETES ENDO
JI Lancet Diabetes Endocrinol.
PD OCT
PY 2014
VL 2
IS 10
BP 773
EP 773
DI 10.1016/S2213-8587(14)70186-X
PG 1
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AY8BF
UT WOS:000347778700008
PM 25258202
ER

PT J
AU Bennett, PH
AF Bennett, Peter H.
TI The Look AHEAD study: a missed opportunity
SO LANCET DIABETES & ENDOCRINOLOGY
LA English
DT Letter
ID LIFE-STYLE INTERVENTION
C1 NIH, Phoenix, AZ 85014 USA.
RP Bennett, PH (reprint author), NIH, Phoenix, AZ 85014 USA.
EM pbennett@nih.gov
NR 5
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2213-8587
J9 LANCET DIABETES ENDO
JI Lancet Diabetes Endocrinol.
PD OCT
PY 2014
VL 2
IS 10
BP 775
EP 776
PG 3
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AY8BF
UT WOS:000347778700011
PM 25282081
ER

PT J
AU Knowler, WC
   Bahnson, JL
   Bantle, JP
   Lewis, CE
AF Knowler, William C.
   Bahnson, Judy L.
   Bantle, John P.
   Lewis, Cora E.
CA Look AHEAD Res Grp
TI Diabetic kidneys do deserve a lifestyle change
SO LANCET DIABETES & ENDOCRINOLOGY
LA English
DT Letter
C1 [Knowler, William C.] Natl Inst Diabet & Digest & Kidney Dis, NIH, Phoenix, AZ USA.
   [Bahnson, Judy L.] Wake Forest Sch Med, Wake Forest Baptist Med Ctr, Winston Salem, NC 27157 USA.
   [Bantle, John P.] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA.
   [Lewis, Cora E.] Univ Alabama Birmingham, Birmingham, AL USA.
RP Knowler, WC (reprint author), Natl Inst Diabet & Digest & Kidney Dis, NIH, Phoenix, AZ USA.
EM jbahnson@wakehealth.edu
NR 4
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2213-8587
J9 LANCET DIABETES ENDO
JI Lancet Diabetes Endocrinol.
PD OCT
PY 2014
VL 2
IS 10
BP 776
EP 776
PG 1
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AY8BF
UT WOS:000347778700013
ER

PT J
AU Kalyani, RR
   Corriere, M
   Ferrucci, L
AF Kalyani, Rita Rastogi
   Corriere, Mark
   Ferrucci, Luigi
TI Age-related and disease-related muscle loss: the effect of diabetes,
   obesity, and other diseases
SO LANCET DIABETES & ENDOCRINOLOGY
LA English
DT Review
ID HUMAN SKELETAL-MUSCLE; NUTRITION EXAMINATION SURVEY; RANDOMIZED
   CONTROLLED-TRIAL; UBIQUITIN-PROTEASOME PATHWAY; BODY-MASS INDEX;
   OLDER-ADULTS; INSULIN-RESISTANCE; SARCOPENIC OBESITY; GROWTH-HORMONE;
   LEAN MASS
AB The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be included in the definition. Irrespective of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly prevalent and important risk factors for disability and potentially mortality in individuals as they age. Many chronic diseases, in addition to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a main underlying mechanism by which chronic diseases cause physical disability. In this Review, we address both age-related and disease-related muscle loss, with a focus on diabetes and obesity but including other disease states, and potential common mechanisms and treatments. Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.
C1 [Kalyani, Rita Rastogi; Corriere, Mark] Johns Hopkins Univ, Dept Med, Div Endocrinol Diabet & Metab, Baltimore, MD USA.
   [Ferrucci, Luigi] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
RP Ferrucci, L (reprint author), NIA, Harbor Hosp, 5th Floor,NM 540,3001 Hanover St, Baltimore, MD 21225 USA.
EM ferruccilu@mail.nih.gov
RI Corriere, Matthew/A-1276-2010
FU US National Institute of Diabetes and Digestive and Kidney Diseases
   [K23-DK093583, T32-DK062707]; Johns Hopkins Older Americans Independence
   Center [P30-AG021334]; US National Institute on Aging
FX The authors are supported by the US National Institute of Diabetes and
   Digestive and Kidney Diseases (K23-DK093583, T32-DK062707), the Johns
   Hopkins Older Americans Independence Center (P30-AG021334), and the
   intramural research programme of the US National Institute on Aging.
NR 142
TC 58
Z9 59
U1 9
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2213-8587
J9 LANCET DIABETES ENDO
JI Lancet Diabetes Endocrinol.
PD OCT
PY 2014
VL 2
IS 10
BP 819
EP 829
DI 10.1016/S2213-8587(14)70034-8
PG 11
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AY8BF
UT WOS:000347778700025
PM 24731660
ER

PT J
AU Iranzo, J
   Lobkovsky, AE
   Wolf, YI
   Koonin, EV
AF Iranzo, Jaime
   Lobkovsky, Alexander E.
   Wolf, Yuri I.
   Koonin, Eugene V.
TI Virus-host arms race at the joint origin of multicellularity and
   programmed cell death
SO CELL CYCLE
LA English
DT Article
DE programmed cell death; host-parasite arms race; viruses; evolution of
   multicellularity; AI; abortive infection; PCD; programmed cell death;
   TA; toxin-antitoxin
ID SENSING BACTERIAL-POPULATIONS; EVOLUTION; SYSTEMS; LIFE; CORE
AB Unicellular eukaryotes and most prokaryotes possess distinct mechanisms of programmed cell death (PCD). How an altruistic trait, such as PCD, could evolve in unicellular organisms? To address this question, we developed a mathematical model of the virus-host co-evolution that involves interaction between immunity, PCD and cellular aggregation. Analysis of the parameter space of this model shows that under high virus load and imperfect immunity, joint evolution of cell aggregation and PCD is the optimal evolutionary strategy. Given the abundance of viruses in diverse habitats and the wide spread of PCD in most organisms, these findings imply that multiple instances of the emergence of multicellularity and its essential attribute, PCD, could have been driven, at least in part, by the virus-host arms race.
C1 [Iranzo, Jaime; Lobkovsky, Alexander E.; Wolf, Yuri I.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Koonin, EV (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
EM koonin@ncbi.nlm.nih.gov
RI Iranzo, Jaime/H-5197-2011
OI Iranzo, Jaime/0000-0002-4538-7726
FU intramural funds of the US Department of Health and Human Services
FX The authors' research is supported by intramural funds of the US
   Department of Health and Human Services (to the National Library of
   Medicine).
NR 35
TC 3
Z9 3
U1 3
U2 18
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD OCT 1
PY 2014
VL 13
IS 19
BP 3083
EP 3088
DI 10.4161/15384101.2014.949496
PG 6
WC Cell Biology
SC Cell Biology
GA AZ6JQ
UT WOS:000348326600015
PM 25486567
ER

PT J
AU Yokel, RA
   Hussain, S
   Garantziotis, S
   Demokritou, P
   Castranova, V
   Cassee, FR
AF Yokel, Robert A.
   Hussain, Salik
   Garantziotis, Stavros
   Demokritou, Philip
   Castranova, Vincent
   Cassee, Flemming R.
TI The yin: an adverse health perspective of nanoceria: uptake,
   distribution, accumulation, and mechanisms of its toxicity
SO ENVIRONMENTAL SCIENCE-NANO
LA English
DT Review
ID CERIUM OXIDE NANOPARTICLES; OXIDATIVE STRESS; CEO2 NANOPARTICLES;
   ENGINEERED NANOMATERIAL; DIOXIDE NANOPARTICLES; GOLD NANOPARTICLES;
   PARTICLE-SIZE; BIOMEDICAL APPLICATIONS; PULMONARY INFLAMMATION; SILVER
   NANOPARTICLES
AB This critical review evolved from a SNO Special Workshop on Nanoceria panel presentation addressing the toxicological risks of nanoceria: accumulation, target organs, and issues of clearance; how exposure dose/concentration, exposure route, and experimental preparation/model influence the different reported effects of nanoceria; and how can safer by design concepts be applied to nanoceria? It focuses on the most relevant routes of human nanoceria exposure and uptake, disposition, persistence, and resultant adverse effects. The pulmonary, oral, dermal, and topical ocular exposure routes are addressed as well as the intravenous route, as the latter provides a reference for the pharmacokinetic fate of nanoceria once introduced into blood. Nanoceria reaching the blood is primarily distributed to mononuclear phagocytic system organs. Available data suggest nanoceria's distribution is not greatly affected by dose, shape, or dosing schedule. Significant attention has been paid to the inhalation exposure route. Nanoceria distribution from the lung to the rest of the body is less than 1% of the deposited dose, and from the gastrointestinal tract even less. Intracellular nanoceria and organ burdens persist for at least months, suggesting very slow clearance rates. The acute toxicity of nanoceria is very low. However, large/accumulated doses produce granuloma in the lung and liver, and fibrosis in the lung. Toxicity, including genotoxicity, increases with exposure time; the effects disappear slowly, possibly due to nanoceria's biopersistence. Nanoceria may exert toxicity through oxidative stress. Adverse effects seen at sites distal to exposure may be due to nanoceria translocation or released biomolecules. An example is elevated oxidative stress indicators in the brain, in the absence of appreciable brain nanoceria. Nanoceria may change its nature in biological environments and cause changes in biological molecules. Increased toxicity has been related to greater surface Ce3+, which becomes more relevant as particle size decreases and the ratio of surface area to volume increases. Given its biopersistence and resulting increased toxicity with time, there is a risk that long-term exposure to low nanoceria levels may eventually lead to adverse health effects. This critical review provides recommendations for research to resolve some of the many unknowns of nanoceria's fate and adverse effects.
C1 [Yokel, Robert A.] Univ Kentucky, Lexington, KY 40506 USA.
   [Yokel, Robert A.] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40506 USA.
   [Hussain, Salik; Garantziotis, Stavros] NIEHS, Clin Res Unit, NIH, Morrisville, NC USA.
   [Demokritou, Philip] Harvard Univ, Cambridge, MA 02138 USA.
   [Castranova, Vincent] NIOSH, Atlanta, GA USA.
   [Castranova, Vincent] W Virginia Univ, Sch Pharm, Morgantown, WV 26506 USA.
   [Cassee, Flemming R.] Natl Inst Publ Hlth & Environm, Ctr Sustainabil Environm & Hlth, NL-3720 BA Bilthoven, Netherlands.
   [Cassee, Flemming R.] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
RP Yokel, RA (reprint author), Univ Kentucky, Lexington, KY 40506 USA.
EM ryokel@uky.edu
RI Garantziotis, Stavros/A-6903-2009
OI Garantziotis, Stavros/0000-0003-4007-375X
FU Sustainable Nanotechnology Organization; NSF grant [CBET-1343638,
   1235806]; Tracy Farmer Institute for Sustainability and the Environment,
   Department of Pharmaceutical Sciences, Office of the Vice President for
   Research, University of Kentucky; US EPA STAR grant [RD-833772];
   Intramural Research Program of the NIH, National Institute of
   Environmental Health Sciences; NIEHS grant [P30ES000002]; Ministry of
   Infrastructures and Environment, the Netherlands
FX This critical review is a product of a workshop on nanoceria held
   November 2, 2013 at Fess Parker's Doubletree Resort, Santa Barbara,
   California which was made possible by financial support from the
   Sustainable Nanotechnology Organization; NSF grant CBET-1343638 to UCSB;
   and the Tracy Farmer Institute for Sustainability and the Environment,
   Department of Pharmaceutical Sciences, Office of the Vice President for
   Research, and Associate Dean for Research of the College of Pharmacy,
   University of Kentucky. The authors' research was supported (in part) by
   US EPA STAR grant RD-833772; the Intramural Research Program of the NIH,
   National Institute of Environmental Health Sciences; NSF grant 1235806;
   NIEHS grant P30ES000002; and the Ministry of Infrastructures and
   Environment, the Netherlands.
NR 137
TC 18
Z9 18
U1 9
U2 42
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2051-8153
EI 2051-8161
J9 ENVIRON SCI-NANO
JI Environ.-Sci. Nano
PD OCT
PY 2014
VL 1
IS 5
BP 406
EP 428
DI 10.1039/c4en00039k
PG 23
WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience &
   Nanotechnology
SC Chemistry; Environmental Sciences & Ecology; Science & Technology -
   Other Topics
GA AZ1BC
UT WOS:000347974400002
PM 25243070
ER

PT J
AU Christov-Moore, L
   Simpson, EA
   Coude, G
   Grigaityte, K
   Iacoboni, M
   Ferrari, PF
AF Christov-Moore, Leonardo
   Simpson, Elizabeth A.
   Coude, Gino
   Grigaityte, Kristina
   Iacoboni, Marco
   Ferrari, Pier Francesco
TI Empathy: Gender effects in brain and behavior
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article
DE Ontogeny; Gender; Sex; Contagion; Mimicry; Prosocial; Helping; Emotion;
   Mirror neuron system; Development; Evolution
ID MIRROR-NEURON SYSTEM; DELIBERATE VICARIOUS REPRESENTATIONS; EMOTIONAL
   FACIAL EXPRESSIONS; AUTISM SPECTRUM DISORDERS; TOY PREFERENCES PARALLEL;
   2ND-TO-4TH DIGIT RATIO; EARLY SEX-DIFFERENCES; INDIVIDUAL-DIFFERENCES;
   PERSPECTIVE-TAKING; MOTOR FACILITATION
AB Evidence suggests that there are differences in the capacity for empathy between males and females. However, how deep do these differences go? Stereotypically, females are portrayed as more nurturing and empathetic, while males are portrayed as less emotional and more cognitive. Some authors suggest that observed gender differences might be largely due to cultural expectations about gender roles. However, empathy has both evolutionary and developmental precursors, and can be studied using implicit measures, aspects that can help elucidate the respective roles of culture and biology. This article reviews evidence from ethology, social psychology, economics, and neuroscience to show that there are fundamental differences in implicit measures of empathy, with parallels in development and evolution. Studies in nonhuman animals and younger human populations (infants/children) offer converging evidence that sex differences in empathy have phylogenetic and ontogenetic roots in biology and are not merely cultural byproducts driven by socialization. We review how these differences may have arisen in response to males' and females' different roles throughout evolution. Examinations of the neurobiological underpinnings of empathy reveal important quantitative gender differences in the basic networks involved in affective and cognitive forms of empathy, as well as a qualitative divergence between the sexes in how emotional information is integrated to support decision making processes. Finally, the study of gender differences in empathy can be improved by designing studies with greater statistical power and considering variables implicit in gender (e.g., sexual preference, prenatal hormone exposure). These improvements may also help uncover the nature of neurodevelopmental and psychiatric disorders in which one sex is more vulnerable to compromised social competence associated with impaired empathy. (C) 2014 Published by Elsevier Ltd.
C1 [Christov-Moore, Leonardo; Grigaityte, Kristina; Iacoboni, Marco] Univ Calif Los Angeles, Brain Res Inst, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
   [Iacoboni, Marco] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
   [Simpson, Elizabeth A.; Coude, Gino; Ferrari, Pier Francesco] Univ Parma, Dipartimento Neurosci, I-43125 Parma, Italy.
   [Simpson, Elizabeth A.] NICHHD, NIH, Dickerson, MD 20842 USA.
   [Grigaityte, Kristina] Univ Edinburgh, Edinburgh, Midlothian, Scotland.
RP Ferrari, PF (reprint author), Univ Parma, Dipartimento Neurosci, Via Volturno 39, I-43125 Parma, Italy.
EM pierfrancesco.ferrari@unipr.it
OI Simpson, Elizabeth/0000-0003-2715-2533
FU NICHD [P01HD064653]; NIH [1R21MH097178]; NSF Graduate Fellowship
   [DGE-1144087]
FX This work was supported by NICHD P01HD064653 to P. F.F., by NIH grant
   1R21MH097178 to M.I., and by NSF Graduate Fellowship DGE-1144087 to
   L.C.-M.
NR 348
TC 38
Z9 42
U1 43
U2 189
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD OCT
PY 2014
VL 46
SI SI
BP 604
EP 627
DI 10.1016/j.neubiorev.2014.09.001
PN 4
PG 24
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AZ1QJ
UT WOS:000348012800012
PM 25236781
ER

PT J
AU Acharya, P
   Zhou, TQ
   Soto, C
   Chen, L
   Luongo, TS
   Moquin, S
   Georgiev, IS
   Schmidt, SD
   Louder, MK
   Joyce, MG
   Yang, YP
   Zhang, BS
   Scheid, J
   Nussenzweig, MC
   Mascola, JR
   Kwong, PD
AF Acharya, Priyamvada
   Zhou, Tongqing
   Soto, Cinque
   Chen, Lei
   Luongo, Timothy S.
   Moquin, Stephanie
   Georgiev, Ivelin S.
   Schmidt, Stephen D.
   Louder, Mark K.
   Joyce, M. Gordon
   Yang, Yongping
   Zhang, Baoshan
   Scheid, Johannes
   Nussenzweig, Michel C.
   Mascola, John R.
   Kwong, Peter D.
TI CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1
   Neutralizers
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Acharya, Priyamvada; Zhou, Tongqing; Soto, Cinque; Chen, Lei; Luongo, Timothy S.; Moquin, Stephanie; Georgiev, Ivelin S.; Schmidt, Stephen D.; Louder, Mark K.; Joyce, M. Gordon; Yang, Yongping; Zhang, Baoshan; Mascola, John R.; Kwong, Peter D.] NIAID, NIH, VRC, Bethesda, MD 20892 USA.
   [Scheid, Johannes; Nussenzweig, Michel C.] Rockefeller Univ, New York, NY 10021 USA.
RI Zhou, Tongqing/A-6880-2010
OI Zhou, Tongqing/0000-0002-3935-4637
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P10.11
BP A120
EP A121
PG 7
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401109
ER

PT J
AU Ake, J
   Ratto-Kim, S
   Schuetz, A
   Wieczorek, L
   Nguay, V
   Kibuuka, H
   Sawe, F
   Maboko, L
   Polonis, V
   Weiner, D
   DeSouza, M
   Sekiziyivu, A
   Kosgei, J
   Missanga, M
   Kroidl, A
   Earl, P
   Moss, B
   Adams, E
   Martinez, A
   Rizvi, F
   Khan, A
   Sardesai, N
   Michael, N
   Marovich, M
   Robb, M
AF Ake, Julie
   Ratto-Kim, Silvia
   Schuetz, Alexandra
   Wieczorek, Lindsay
   Nguay, Viseth
   Kibuuka, Hannah
   Sawe, Fredrick
   Maboko, Leonard
   Polonis, Victoria
   Weiner, David
   DeSouza, Mark
   Sekiziyivu, Arthur
   Kosgei, Josphat
   Missanga, Marco
   Kroidl, Arne
   Earl, Patricia
   Moss, Bernard
   Adams, Elizabeth
   Martinez, Ana
   Rizvi, Farrukh
   Khan, Amir
   Sardesai, Niranjan
   Michael, Nelson
   Marovich, Mary
   Robb, Merlin
CA RV 262 Study Grp
TI Phase 1 Trial of the Safety and Immunogenicity of PENNVAX (R)-G DNA
   Prime Administered by Biojector (R) 2000 or CELLECTRA (R) EP Device with
   MVA-CMDR Boost
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Ake, Julie; Ratto-Kim, Silvia; Wieczorek, Lindsay; Nguay, Viseth; Polonis, Victoria; Michael, Nelson; Robb, Merlin] WRAIR, US Mil HIV Res Program, Silver Spring, MD USA.
   [Schuetz, Alexandra; DeSouza, Mark] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand.
   [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda.
   [Sawe, Fredrick; Kosgei, Josphat] KEMRI, Walter Reed Project, Kericho, Kenya.
   [Maboko, Leonard; Missanga, Marco; Kroidl, Arne] Mbeya Med Res Ctr, Mbeya, Tanzania.
   [Weiner, David] Univ Penn, Philadelphia, PA 19104 USA.
   [Kroidl, Arne] Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany.
   [Earl, Patricia; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
   [Adams, Elizabeth; Martinez, Ana; Marovich, Mary] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
   [Rizvi, Farrukh] Mil Infect Dis Res Program, Ft Detrick, MD USA.
   [Khan, Amir; Sardesai, Niranjan] Inovio Pharmaceut Inc, Blue Bell, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P26.02
BP A186
EP A186
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402109
ER

PT J
AU Alexandre, KB
   Buckheit, KW
   Haugh-Krumpe, L
   Constantine, B
   Buckheit, RW
   O'Keefe, BR
AF Alexandre, Kabamba Bankoledi
   Buckheit, Karen W.
   Haugh-Krumpe, Lauren
   Constantine, Brian
   Buckheit, Robert W.
   O'Keefe, Barry R.
TI HIV-1 Shows Increased Sensitivity to Griffithsin Derivatives
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Alexandre, Kabamba Bankoledi] CSIR, Pretoria, South Africa.
   [Buckheit, Karen W.; Buckheit, Robert W.] ImQuest BioSci, Frederick, MD USA.
   [Haugh-Krumpe, Lauren; Constantine, Brian; O'Keefe, Barry R.] NCI, Mol Target Lab, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P33.01
BP A203
EP A203
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402152
ER

PT J
AU Allen, MA
   Metch, B
   Moodie, Z
   Bekker, LG
   Churchyard, G
   Mlisana, K
   Nchabeleng, M
   Kublin, J
   Gray, G
AF Allen, Mary A.
   Metch, Barbara
   Moodie, Zoe
   Bekker, Linda-Gail
   Churchyard, Gavin
   Mlisana, Koleka
   Nchabeleng, Maphoshane
   Kublin, Jim
   Gray, Glenda
CA HVTN 30 Study Team
TI Self-reported Benefits of Study Participation in HVTN 503, "Phambili"
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Allen, Mary A.] NIAID, NIH, DAIDS, Bethesda, MD 20892 USA.
   [Metch, Barbara; Moodie, Zoe; Kublin, Jim] FHCRC, Seattle, WA USA.
   [Bekker, Linda-Gail] Desmond Tutu HIV Fdn, Cape Town, South Africa.
   [Churchyard, Gavin] Aurum Inst, Klerksdorp, South Africa.
   [Mlisana, Koleka] Univ KwaZulu Natal, Durban, South Africa.
   [Nchabeleng, Maphoshane] Medunsa Clin Res Unit, Medunsa, South Africa.
   [Gray, Glenda] Chris Hani Baragwanath Hosp, PHRU, Soweto, South Africa.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P42.01
BP A251
EP A251
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403100
ER

PT J
AU Arakelyan, A
   King, D
   Grivel, JC
   Shattock, RJ
   Margolis, L
AF Arakelyan, Anush
   King, Debbie
   Grivel, Jean-Charled
   Shattock, Robin J.
   Margolis, Leonid
TI Heterogeneous Conformation of HIV-1 Envelopes on Individual Virions
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Arakelyan, Anush; Grivel, Jean-Charled; Margolis, Leonid] NICHD, NIH, Sect Intercellular Interact, Bethesda, MD USA.
   [King, Debbie; Shattock, Robin J.] Univ London Imperial Coll Sci Technol & Med, London, England.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA30.06 LB
BP A78
EP A79
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401010
ER

PT J
AU Archer, EJ
   Bashford-Rogers, R
   Hill, B
   Douek, DC
   Kellam, P
   Koup, RA
AF Archer, Eva J.
   Bashford-Rogers, Rachael
   Hill, Brenna
   Douek, Daniel C.
   Kellam, Paul
   Koup, Richard A.
TI Evolution of Antigen-specific B-cell Receptor Repertoires in Early SIV
   Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Archer, Eva J.; Hill, Brenna; Douek, Daniel C.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Archer, Eva J.; Bashford-Rogers, Rachael; Kellam, Paul] Wellcome Trust Sanger Inst, Hinxton, England.
   [Archer, Eva J.] Univ Cambridge, Cambridge, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA06.01
BP A19
EP A19
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400032
ER

PT J
AU Bouvin-Pley, M
   Morgand, M
   Moreau, A
   Meyer, L
   Goujard, C
   Mouquet, H
   Nussenzweig, MC
   Pace, CS
   Ho, DD
   Bjorkman, PJ
   Baty, D
   Chames, P
   Pancera, M
   Kwong, PD
   Poignard, P
   Barin, F
   Braibant, M
AF Bouvin-Pley, Melanie
   Morgand, Marion
   Moreau, Alain
   Meyer, Laurence
   Goujard, Cecile
   Mouquet, Hugo
   Nussenzweig, Michel C.
   Pace, Craig S.
   Ho, David D.
   Bjorkman, Pamela J.
   Baty, Daniel
   Chames, Patrick
   Pancera, Marie
   Kwong, Peter D.
   Poignard, Pascal
   Barin, Francis
   Braibant, Martine
TI Adaptation of HIV-1 Envelope Glycoprotein gp120 to Humoral Immunity over
   the Course of the Epidemic
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Bouvin-Pley, Melanie; Morgand, Marion; Moreau, Alain; Barin, Francis; Braibant, Martine] INSERM, U966, Tours, France.
   [Meyer, Laurence; Goujard, Cecile] INSERM, U1018, CESP, Paris, France.
   [Meyer, Laurence; Goujard, Cecile] Hop Bicetre, AP HP, Le Kremlin Bicetre, France.
   [Mouquet, Hugo] Inst Pasteur, Paris, France.
   [Nussenzweig, Michel C.] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA.
   [Pace, Craig S.; Ho, David D.] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA.
   [Bjorkman, Pamela J.] CALTECH, Pasadena, CA 91125 USA.
   [Baty, Daniel; Chames, Patrick] INSERM, U1068, CRCM, F-13258 Marseille, France.
   [Pancera, Marie; Kwong, Peter D.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Poignard, Pascal] Scripps Res Inst, IAVI, Neutralizing Antibody Ctr, La Jolla, CA 92037 USA.
   [Barin, Francis] CHU Bretonneau, Lab Bacteriol Virol, F-37044 Tours, France.
RI poignard, pascal/N-6678-2013
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P39.02
BP A224
EP A224
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403029
ER

PT J
AU Buchbinder, SP
   Hay, C
   Grunenberg, N
   Goepfert, P
   Georgia, T
   Seaton, K
   Sato, A
   Elizaga, M
   Yu, XS
   Gilbert, P
   Moss, B
   Robinson, H
AF Buchbinder, Susan P.
   Hay, Christine
   Grunenberg, Nicole
   Goepfert, Paul
   Georgia, Tomaras
   Seaton, Kelly
   Sato, Alicia
   Elizaga, Marnie
   Yu, Xuesong
   Gilbert, Peter
   Moss, Bernard
   Robinson, Harriet
TI VLP-expressing DNA/MVA Vaccines: The Effect of Schedule and Regimen on
   Antibody Magnitude and Avidity
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Buchbinder, Susan P.] San Francisco Dept Publ Hlth, Bridge HIV, San Francisco, CA USA.
   [Buchbinder, Susan P.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Hay, Christine] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
   [Grunenberg, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Goepfert, Paul] Univ Alabama Birmingham, Birmingham, AL USA.
   [Georgia, Tomaras; Seaton, Kelly] Duke HumanVaccine Inst, Durham, NC USA.
   [Sato, Alicia; Yu, Xuesong; Gilbert, Peter] FHCRC, SCHARP, Seattle, WA USA.
   [Moss, Bernard] NIAID, NIH, Bethesda, MD 20892 USA.
   [Robinson, Harriet] GeoVax Inc, Smyrna, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA11.03
BP A32
EP A32
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400064
ER

PT J
AU Cale, EM
   Doria-Rose, NA
   Tong, T
   Crooks, ET
   Nguyen, R
   Ambrozak, DR
   Perfetto, SP
   Roederer, M
   Binley, JM
   Mascola, JR
AF Cale, Evan M.
   Doria-Rose, Nicole A.
   Tong, Tommy
   Crooks, Ema T.
   Richard Nguyen
   Ambrozak, David R.
   Perfetto, Stephen P.
   Roederer, Mario
   Binley, James M.
   Mascola, John R.
TI Use of Enzyme-digested Virus-like Particles as Probes for Flow
   Cytometric Sorting of HIV-specific Neutralizing Ab-producing B-cells
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Cale, Evan M.; Doria-Rose, Nicole A.; Richard Nguyen; Ambrozak, David R.; Perfetto, Stephen P.; Roederer, Mario; Mascola, John R.] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Tong, Tommy; Crooks, Ema T.; Binley, James M.] Torrey Pines Inst Mol Studies, San Diego, CA USA.
   [Tong, Tommy; Crooks, Ema T.; Binley, James M.] San Diego Biomed Res Inst, San Diego, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA06.04
BP A20
EP A20
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400035
ER

PT J
AU Chen, L
   Kwong, PD
AF Chen, Lei
   Kwong, Peter D.
TI "Canyon Shielding" of the CD4-Binding Site on HIV-1 Trimer
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Chen, Lei; Kwong, Peter D.] NIAID, VRC, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P10.02
BP A117
EP A117
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401100
ER

PT J
AU Cheng, C
   Georgiev, I
   Joyce, MG
   Chen, XJ
   Bossert, A
   Kong, WP
   Kwong, PD
   Mascola, JR
AF Cheng, Cheng
   Georgiev, Ivelin
   Joyce, M. Gordon
   Chen, Xuejun
   Bossert, Adam
   Kong, Wing-Pui
   Kwong, Peter D.
   Mascola, John R.
TI Optimization of a Clade A Env Outer Domain for Enhanced Binding to
   Germlines of Diverse VRC01 Class Antibodies
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Cheng, Cheng; Georgiev, Ivelin; Joyce, M. Gordon; Chen, Xuejun; Bossert, Adam; Kong, Wing-Pui; Kwong, Peter D.; Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P10.03
BP A117
EP A118
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401101
ER

PT J
AU Cicala, C
   Jelicic, K
   Cimbro, R
   Nawaz, F
   Zheng, X
   Yang, J
   Lempicki, R
   Van Ryk, D
   Ray, J
   Hiatt, J
   Schwing, C
   Wei, DL
   Pascuccio, M
   Kehrl, J
   Arthos, J
   Fauci, AS
AF Cicala, Claudia
   Jelicic, Katija
   Cimbro, Raffaello
   Nawaz, Fatima
   Zheng, Xin
   Yang, Jun
   Lempicki, Richard
   Van Ryk, Donald
   Ray, Jocelyn
   Hiatt, Joseph
   Schwing, Catherine
   Wei, Danlan
   Pascuccio, Massimiliano
   Kehrl, John
   Arthos, James
   Fauci, Anthony S.
TI HIV-1 gp120 Impairs B Cell Proliferation by Inducing TGF-beta 1
   Production and FcRL4 Expression
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Cicala, Claudia; Jelicic, Katija; Cimbro, Raffaello; Nawaz, Fatima; Van Ryk, Donald; Ray, Jocelyn; Hiatt, Joseph; Schwing, Catherine; Wei, Danlan; Pascuccio, Massimiliano; Kehrl, John; Arthos, James; Fauci, Anthony S.] NIAID, NIH, LIR, Bethesda, MD 20892 USA.
   [Zheng, Xin; Yang, Jun; Lempicki, Richard] NIAID, NIH, Lab Immunopathogenesis & Bioinformat, SAIC, Frederick, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P34.02
BP A207
EP A208
PG 6
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402164
ER

PT J
AU Claiborne, D
   Prince, J
   Scully, E
   Kopycinski, J
   Macharia, G
   Nganou-Makamdop, K
   Tang, JM
   Goepfert, P
   Yu, TW
   Lakhi, S
   Kilembe, W
   Douek, D
   Gilmour, J
   Price, M
   Altfeld, M
   Allen, S
   Hunter, E
AF Claiborne, Daniel
   Prince, Jessica
   Scully, Eileen
   Kopycinski, Jakob
   Macharia, Gladys
   Nganou-Makamdop, Krystelle
   Tang, Jianming
   Goepfert, Paul
   Yu, Tianwei
   Lakhi, Shabir
   Kilembe, William
   Douek, Daniel
   Gilmour, Jill
   Price, Matthew
   Altfeld, Marcus
   Allen, Susan
   Hunter, Eric
TI Protective HLA Alleles Reduce Markers of Gut Damage and Microbial
   Translocation and Preserve the Cellular Immune Response during Acute
   HIV-1 Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Claiborne, Daniel; Prince, Jessica; Yu, Tianwei; Allen, Susan; Hunter, Eric] Emory Univ, Atlanta, GA 30322 USA.
   [Scully, Eileen] Ragon Inst MGH MIT & Harvard, Boston, MA USA.
   [Kopycinski, Jakob; Macharia, Gladys; Gilmour, Jill; Price, Matthew] IAVI, London, England.
   [Nganou-Makamdop, Krystelle; Douek, Daniel] NIAID, NIH, Bethesda, MD 20892 USA.
   [Tang, Jianming; Goepfert, Paul] Univ Alabama Birmingham, Birmingham, AL USA.
   [Lakhi, Shabir; Kilembe, William; Allen, Susan] ZEHRP, Lusaka, Zambia.
   [Price, Matthew] UCSF, San Francisco, CA USA.
   [Altfeld, Marcus] Leibniz Inst Expt Virol, Heinrich Pette Inst, Hamburg, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA14.01
BP A39
EP A39
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400080
ER

PT J
AU Dawson, L
AF Dawson, Liza
TI Ethics of HIV Prevention Research with Pregnant Women
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Dawson, Liza] NIAID, NIH, Div Aids, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P45.03
BP A266
EP A266
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403140
ER

PT J
AU De Rosa, S
   Frahm, N
   Diaz, G
   Newling, P
   Morris, D
   Morgan, C
   Graham, B
   Swann, E
   Tomaras, G
   Maenza, J
   Duerr, A
   McElrath, MJ
AF De Rosa, Stephen
   Frahm, Nicole
   Diaz, Gabriela
   Newling, Paul
   Morris, Daryl
   Morgan, Cecilia
   Graham, Barney
   Swann, Edith
   Tomaras, Georgia
   Maenza, Janine
   Duerr, Ann
   McElrath, M. Juliana
TI No Increase in Activated T Cells and Limited Increase in
   Adenovirus-specific T Cells in Colon and Rectal Mucosa Following HIV-1
   DNA/rAd5 Immunization
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [De Rosa, Stephen; Frahm, Nicole; Diaz, Gabriela; Newling, Paul; Morris, Daryl; Morgan, Cecilia; Maenza, Janine; Duerr, Ann; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Graham, Barney] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Swann, Edith] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
   [Tomaras, Georgia] Duke Univ, Durham, NC USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA17.06
BP A48
EP A48
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400103
ER

PT J
AU Doria-Rose, NA
   Roark, RS
   Moore, P
   Ernandes, MJ
   Bhiman, JN
   Schramm, CA
   McKee, K
   O'Dell, S
   Louder, M
   Karim, SSA
   Shapiro, L
   Morris, L
   Mascola, JR
AF Doria-Rose, Nicole A.
   Roark, Ryan S.
   Moore, Penny
   Ernandes, Michael J.
   Bhiman, Jinal N.
   Schramm, Chaim A.
   McKee, Krisha
   O'Dell, Sijy
   Louder, Mark
   Karim, Salim S. Abdool
   Shapiro, Lawrence
   Morris, Lynn
   Mascola, John R.
TI Variable Dependence on Glycan Recognition within a Lineage of
   V1V2-directed HIV Neutralizing Antibodies
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Doria-Rose, Nicole A.; Roark, Ryan S.; Ernandes, Michael J.; McKee, Krisha; O'Dell, Sijy; Louder, Mark; Mascola, John R.] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Moore, Penny; Bhiman, Jinal N.; Morris, Lynn] Univ Witwatersrand, Johannesburg, South Africa.
   [Moore, Penny; Bhiman, Jinal N.; Morris, Lynn] NICD, Johannesburg, South Africa.
   [Bhiman, Jinal N.; Karim, Salim S. Abdool; Morris, Lynn] Ctr AIDS Programme Res South Africa CAPRISA, Congella, South Africa.
   [Schramm, Chaim A.; Shapiro, Lawrence] Columbia Univ, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA PD05.02
BP A88
EP A89
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401032
ER

PT J
AU Druz, A
   Pancera, M
   Acharya, P
   Zhou, TQ
   Joyce, G
   Ofek, A
   Kwong, PD
AF Druz, Alex
   Pancera, Marie
   Acharya, Priyamvada
   Zhou, Tongqing
   Joyce, Gordon
   Ofek, Adi
   Kwong, Peter D.
TI Transient Protein Expression Facilitates X-ray Structural Studies of
   HIV-1
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Druz, Alex; Pancera, Marie; Acharya, Priyamvada; Zhou, Tongqing; Joyce, Gordon; Ofek, Adi; Kwong, Peter D.] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
RI Zhou, Tongqing/A-6880-2010
OI Zhou, Tongqing/0000-0002-3935-4637
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P15.21
BP A148
EP A149
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402011
ER

PT J
AU Edlefsen, PT
   Rolland, M
   Hertz, T
   Tovanabutra, S
   Gartland, AJ
   deCamp, AC
   Magaret, CA
   Ahmed, H
   Gottardo, R
   Juraska, M
   McCoy, C
   Larsen, BB
   Sanders-Buell, E
   Carrico, C
   Menis, S
   Bose, M
   Arroyo, MA
   O'Connell, RJ
   deSouza, MS
   Nitayaphan, S
   Pitisuttithum, P
   Kaewkungwal, J
   Rerks-Ngarm, S
   Robb, ML
   McLellan, JS
   Georgiev, IS
   Kirys, T
   Kwong, PD
   Carlson, JM
   Michael, NL
   Schief, WR
   Mullins, JI
   Kim, JH
   Gilbert, PB
AF Edlefsen, Paul T.
   Rolland, Morgane
   Hertz, Tomer
   Tovanabutra, Sodsai
   Gartland, Andrew J.
   deCamp, Allan C.
   Magaret, Craig A.
   Ahmed, Hasan
   Gottardo, Raphael
   Juraska, Michal
   McCoy, Connor
   Larsen, Brendan B.
   Sanders-Buell, Eric
   Carrico, Chris
   Menis, Sergey
   Bose, Meera
   Arroyo, Miguel A.
   O'Connell, Robert J.
   deSouza, Mark S.
   Nitayaphan, Sorachai
   Pitisuttithum, Punnee
   Kaewkungwal, Jaranit
   Rerks-Ngarm, Supachai
   Robb, Merlin L.
   McLellan, Jason S.
   Georgiev, Ivelin S.
   Kirys, Tatsiana
   Kwong, Peter D.
   Carlson, Jonathan M.
   Michael, Nelson L.
   Schief, William R.
   Mullins, James I.
   Kim, Jerome H.
   Gilbert, Peter B.
CA RV144 Sequencing Team
TI Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the
   RV144 Vaccine Efficacy Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Edlefsen, Paul T.; Hertz, Tomer; Gartland, Andrew J.; deCamp, Allan C.; Magaret, Craig A.; Ahmed, Hasan; Gottardo, Raphael; Juraska, Michal; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Rolland, Morgane; Tovanabutra, Sodsai; Sanders-Buell, Eric; Bose, Meera; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Silver Spring, MD USA.
   [McCoy, Connor] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
   [Larsen, Brendan B.; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA.
   [Carrico, Chris; Menis, Sergey; Schief, William R.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA.
   [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA.
   [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA.
   [Arroyo, Miguel A.; Nitayaphan, Sorachai; Kaewkungwal, Jaranit] Royal Thai Army Component, AFRIMS, Bangkok, Thailand.
   [O'Connell, Robert J.; deSouza, Mark S.] US Army Component, AFRIMS, Bangkok, Thailand.
   [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
   [Rerks-Ngarm, Supachai] Thai Minist Publ Hlth, Nonthaburi, Thailand.
   [McLellan, Jason S.; Georgiev, Ivelin S.; Kirys, Tatsiana; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Carlson, Jonathan M.] Microsoft Res, Redmond, WA USA.
   [Schief, William R.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA08.04
BP A25
EP A26
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400047
ER

PT J
AU Felber, BK
   Hu, XT
   Kulkarni, V
   Valentin, A
   Rosati, M
   Alicea, C
   Rolland, M
   Le Gall, S
   Sardesai, NY
   Mothe, B
   Brander, C
   Mullins, JI
   Pavlakis, GN
AF Felber, Barbara K.
   Hu, Xintao
   Kulkarni, Viraj
   Valentin, Antonio
   Rosati, Margherita
   Alicea, Candido
   Rolland, Morgane
   Le Gall, Sylvie
   Sardesai, Niranjan Y.
   Mothe, Beatriz
   Brander, Christian
   Mullins, James I.
   Pavlakis, George N.
TI Expanded Epitope Recognition by Vaccination with DNA Encoding Novel
   Immunogens Comprising HIV Conserved Elements
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Felber, Barbara K.; Hu, Xintao; Kulkarni, Viraj; Valentin, Antonio; Rosati, Margherita; Alicea, Candido; Pavlakis, George N.] NCI, Frederick, MD 21701 USA.
   [Rolland, Morgane; Mullins, James I.] Univ Washington, Seattle, MD USA.
   [Le Gall, Sylvie] Ragon Inst MGH MIT & Harvard, Boston, MD USA.
   [Sardesai, Niranjan Y.] Inovio Pharmaceut Inc, Blue Bell, PA USA.
   [Mothe, Beatriz; Brander, Christian] Autonomous Univ Barcelona, IrsiCaixa AIDS Res Inst HIVACAT, Barcelona, Spain.
   [Brander, Christian] ICREA, Barcelona, Spain.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA16.05
BP A45
EP A46
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400096
ER

PT J
AU Feng, Y
   Jiang, H
   Ingale, J
   McKee, K
   Mascola, J
   Wyatt, R
AF Feng, Yu
   Jiang, Hao
   Ingale, Jidnyasa
   McKee, Krisa
   Mascola, John
   Wyatt, Richard
TI Antigenicity and Immunogenicity of Disulfide-stabilized HIV-1 Envelope
   Glycoprotein Oligomers
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Feng, Yu; Jiang, Hao; Wyatt, Richard] Scripps Res Inst, Int AIDS Vaccine Initiat, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA.
   [Ingale, Jidnyasa; Wyatt, Richard] Scripps Res Inst, La Jolla, CA 92037 USA.
   [McKee, Krisa; Mascola, John] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA PD03.03
BP A84
EP A85
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401023
ER

PT J
AU Fourati, S
   Vaccari, M
   Gordon, SN
   Schifanella, L
   Cameron, M
   Keele, BF
   Shen, XY
   Tomoras, GD
   Billings, E
   Rao, M
   Chung, AW
   Dowell, K
   Bailey-Kellogg, C
   Brown, E
   Ackerman, ME
   Liyanage, NPM
   Vargas-Inchaistegui, DA
   Whitney, S
   Doster, MN
   Binello, N
   Pegu, P
   Montefiori, DC
   Foulds, K
   Quinn, DS
   Donaldson, M
   Liang, F
   Lore, K
   Roederer, M
   Koup, RA
   McDermott, A
   Ma, ZM
   Miller, CJ
   Phan, TB
   Forthal, DN
   Blackburn, M
   Caccuri, F
   Ferrari, G
   Thompson, D
   Robert-Guroff, M
   Ratto-Kim, S
   Kim, JH
   Michael, NL
   Phogat, S
   Barnett, SW
   Tartaglia, J
   Venzon, D
   Stablein, DM
   Alter, G
   Sekaly, RP
   Franchini, G
AF Fourati, Slim
   Vaccari, Monica
   Gordon, Shari N.
   Schifanella, Luca
   Cameron, Mark
   Keele, Brandon F.
   Shen, Xiaoying
   Tomoras, Georgia D.
   Billings, Erik
   Rao, Mangala
   Chung, Amy W.
   Dowell, Karen
   Bailey-Kellogg, Chris
   Brown, Eric
   Ackerman, Margaret E.
   Liyanage, Namal P. M.
   Vargas-Inchaistegui, Diego A.
   Whitney, Stephen
   Doster, Melvin N.
   Binello, Nicolo
   Pegu, Poonam
   Montefiori, David C.
   Foulds, Kathryn
   Quinn, David S.
   Donaldson, Mitzi
   Liang, Frank
   Lore, Karin
   Roederer, Mario
   Koup, Richard A.
   McDermott, Adrian
   Ma, Zhong-Min
   Miller, Christopher J.
   Phan, Tran B.
   Forthal, Donald N.
   Blackburn, Matthew
   Caccuri, Francesca
   Ferrari, Guido
   Thompson, Devon
   Robert-Guroff, Marjorie
   Ratto-Kim, Silvia
   Kim, Jerome H.
   Michael, Nelson L.
   Phogat, Sanjay
   Barnett, Susan W.
   Tartaglia, James
   Venzon, David
   Stablein, Donald M.
   Alter, Galit
   Sekaly, Rafick-Pierre
   Franchini, Genoveffa
TI Modulation of RAS Pathways as a Biomarker of Protection against HIV and
   as a Means to Improve Vaccine Efficacy
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Fourati, Slim; Cameron, Mark] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA.
   [Vaccari, Monica; Gordon, Shari N.; Schifanella, Luca; Liyanage, Namal P. M.; Doster, Melvin N.; Binello, Nicolo; Pegu, Poonam; Blackburn, Matthew; Caccuri, Francesca; Franchini, Genoveffa] NCI, Anim Models & Vaccine Sect, Bethesda, MD 20892 USA.
   [Keele, Brandon F.] NCI, AIDS & Canc Virus Program, Frederick, MD 21701 USA.
   [Shen, Xiaoying; Tomoras, Georgia D.] Duke Human Vaccine Inst, Durham, NC USA.
   [Billings, Erik; Rao, Mangala; Ratto-Kim, Silvia; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA.
   [Chung, Amy W.; Alter, Galit] Ragon Inst MGH MIT & Harvard, Boston, MA USA.
   [Dowell, Karen; Bailey-Kellogg, Chris] Dartmouth Coll, Hanover, NH 03755 USA.
   [Brown, Eric; Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
   [Vargas-Inchaistegui, Diego A.; Robert-Guroff, Marjorie] NCI, Immune Biol Retroviral Infect Sect, Bethesda, MD 20892 USA.
   [Whitney, Stephen; Thompson, Devon] Adv BioSci Labs Inc, Rockville, MD USA.
   [Montefiori, David C.; Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC USA.
   [Foulds, Kathryn; Liang, Frank; Lore, Karin; Roederer, Mario; Koup, Richard A.; McDermott, Adrian] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Quinn, David S.; Donaldson, Mitzi] Karolinska Inst, Stockholm, Sweden.
   [Ma, Zhong-Min; Miller, Christopher J.] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA.
   [Phan, Tran B.; Forthal, Donald N.] Univ Calif Davis, Sch Med, Davis, CA 95616 USA.
   [Phogat, Sanjay; Tartaglia, James] Sanofi Pasteur, Swiftwater, PA USA.
   [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA.
   [Venzon, David] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA.
   [Stablein, Donald M.] EMMES Corp, Rockville, MD USA.
   [Sekaly, Rafick-Pierre] Case Western Reserve Univ, Cleveland, OH 44106 USA.
NR 0
TC 2
Z9 2
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P03.04 LB
BP A99
EP A99
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401055
ER

PT J
AU Frahm, N
   Manso, BA
   De Rosa, SC
   Ochsenbauer, C
   Karuna, S
   Sobieszczyk, M
   Hammer, S
   Swann, E
   Graham, B
   Gilbert, P
   McElrath, MJ
AF Frahm, Nicole
   Manso, Bryce A.
   De Rosa, Stephen C.
   Ochsenbauer, Christina
   Karuna, Shelly
   Sobieszczyk, Magdalena
   Hammer, Scott
   Swann, Edith
   Graham, Barney
   Gilbert, Peter
   McElrath, Margaret Juliana
CA NIAID HIV Vaccine Trials Network
TI CD8(+) T-cell Mediated HIV Inhibition after Vaccination with a
   DNA/Recombinant Ad5 (rAd5) HIV Vaccine Is Similar to that Seen in
   Treated HIV Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Frahm, Nicole; Manso, Bryce A.; De Rosa, Stephen C.; Karuna, Shelly; Gilbert, Peter; McElrath, Margaret Juliana] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Frahm, Nicole; McElrath, Margaret Juliana] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
   [De Rosa, Stephen C.; McElrath, Margaret Juliana] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA.
   [Ochsenbauer, Christina] Univ Alabama Birmingham, Birmingham, AL USA.
   [Sobieszczyk, Magdalena; Hammer, Scott] Columbia Univ, New York, NY USA.
   [Swann, Edith] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
   [Graham, Barney] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Gilbert, Peter] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA PD03.01 LB
BP A84
EP A84
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401021
ER

PT J
AU Francica, J
   Sheng, ZZ
   Nishimura, Y
   Zhang, ZH
   Singh, M
   O'Hagan, DT
   Douek, D
   Kepler, T
   Martin, M
   Shapiro, L
   Seder, R
AF Francica, Joseph
   Sheng, Zizhang
   Nishimura, Yoshiaki
   Zhang, Zhenghai
   Singh, Manmohan
   O'Hagan, Derek T.
   Douek, Daniel
   Kepler, Thomas
   Martin, Malcolm
   Shapiro, Lawrence
   Seder, Robert
TI Genetic Assessment of B-cell Responses Following Immunization with HIV
   Env Protein and Adjuvants or SHIV (AD8) Infection in Nonhuman Primates
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Francica, Joseph; Nishimura, Yoshiaki; Douek, Daniel; Martin, Malcolm; Seder, Robert] NIH, Bethesda, MD 20892 USA.
   [Sheng, Zizhang; Zhang, Zhenghai; Shapiro, Lawrence] Columbia Univ, New York, NY USA.
   [Singh, Manmohan; O'Hagan, Derek T.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA.
   [Kepler, Thomas] Boston Univ, Boston, MA 02215 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA16.04
BP A45
EP A45
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400095
ER

PT J
AU Georgiev, I
   Joyce, MG
   Yang, YP
   Pancera, M
   Gorman, J
   Acharya, P
   Stewart-Jones, G
   Druz, A
   Cheng, C
   Mascola, JR
   Kwong, PD
AF Georgiev, Ivelin
   Joyce, M. Gordon
   Yang, Yongping
   Pancera, Marie
   Gorman, Jason
   Acharya, Priyamvada
   Stewart-Jones, Guillaume
   Druz, Aliaksandr
   Cheng, Cheng
   Mascola, John R.
   Kwong, Peter D.
TI Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer
   Conformation and Antigenicity
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Georgiev, Ivelin; Joyce, M. Gordon; Yang, Yongping; Pancera, Marie; Gorman, Jason; Acharya, Priyamvada; Stewart-Jones, Guillaume; Druz, Aliaksandr; Cheng, Cheng; Mascola, John R.; Kwong, Peter D.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA01.06
BP A9
EP A9
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400007
ER

PT J
AU Ghneim, K
   Caskey, M
   Trumpfheller, C
   Breton, G
   Stafova, P
   Richards, S
   Koup, R
   Bailor, B
   Schlesinger, S
   Ahlers, J
   Sekaly, RP
   Steinman, R
   Cameron, M
AF Ghneim, Khader
   Caskey, Marina
   Trumpfheller, Christine
   Breton, Gaelle
   Stafova, Petra
   Richards, Stephanie
   Koup, Richard
   Bailor, Bob
   Schlesinger, Sarah
   Ahlers, Jeff
   Sekaly, Rafick P.
   Steinman, Ralph
   Cameron, Mark
TI IL-1R, WNT and gamma-C Cytokine Receptor Signaling Correlate with CD4 T
   Cell Effector Function in Response to Anti-DEC205-HIV gag p24/polyICLC
   Vaccination
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Ghneim, Khader; Stafova, Petra; Richards, Stephanie; Ahlers, Jeff; Cameron, Mark] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA.
   [Caskey, Marina; Trumpfheller, Christine; Breton, Gaelle; Schlesinger, Sarah; Steinman, Ralph] Rockefeller Univ, New York, NY 10021 USA.
   [Koup, Richard] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Bailor, Bob] NIAID, Vaccine Res Ctr, Vaccine Immune T Cell & Antibody Lab, NIH, Bethesda, MD 20892 USA.
   [Sekaly, Rafick P.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P41.30 LB
BP A250
EP A251
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403099
ER

PT J
AU Gorman, J
   Yang, Y
   Druz, A
   Baxa, U
   Kwong, PD
AF Gorman, Jason
   Yang, Yongping
   Druz, Aliaksandr
   Baxa, Ulrich
   Kwong, Peter D.
TI Structure-based Design of Trimeric V1V2 Antigens
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Gorman, Jason; Yang, Yongping; Druz, Aliaksandr; Kwong, Peter D.] NIAID, NIH, VRC, Struct Biol Sect, Bethesda, MD 20892 USA.
   [Baxa, Ulrich] NCI, NIH, Canc Res Technol Program, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA 0A01.01
BP A7
EP A7
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400002
ER

PT J
AU Gray, GE
   Andersen-Nissen, E
   Grunenberg, N
   Huang, Y
   Roux, S
   Laher, F
   Innes, C
   Gu, NY
   DiazGranados, C
   Phogat, S
   Lee, C
   Swann, E
   Kim, J
   O'Connell, R
   Michael, N
   Flach, B
   DeRosa, S
   Frahm, N
   Morris, L
   Montefiori, D
   Gilbert, P
   Tomaras, G
   McElrath, J
   Corey, L
AF Gray, Glenda E.
   Andersen-Nissen, Erica
   Grunenberg, Nicole
   Huang, Ying
   Roux, Surita
   Laher, Fatima
   Innes, Craig
   Gu, Niya
   DiazGranados, Carlos
   Phogat, Sanjay
   Lee, Carter
   Swann, Edith
   Kim, Jerome
   O'Connell, Robert
   Michael, Nelson
   Flach, Britta
   DeRosa, Steve
   Frahm, Nicole
   Morris, Lynn
   Montefiori, David
   Gilbert, Peter
   Tomaras, Georgia
   McElrath, Julie
   Corey, Lawrence
CA HVTN 097
TI HVTN 097: Evaluation of the RV144 Vaccine Regimen in HIV Uninfected
   South African Adults
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Gray, Glenda E.] South African Med Res Council, Cape Town, South Africa.
   [Gray, Glenda E.] Perinatal & HIV Res Unit, Soweto, South Africa.
   [Andersen-Nissen, Erica; Flach, Britta; McElrath, Julie] Hutchinson Ctr Res Inst, Cape Town HVTN Immunol Lab, Cape Town, South Africa.
   [Grunenberg, Nicole; Corey, Lawrence] Fred Hutchinson Canc Res Ctr, HVTN, Seattle, WA 98104 USA.
   [Huang, Ying; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA.
   [Roux, Surita] Univ Cape Town, IIDMM, Desmond Tutu HIV Fdn, ZA-7925 Cape Town, South Africa.
   [Laher, Fatima] Univ Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, Soweto, South Africa.
   [Innes, Craig] Klerksdorp HVTN CRS, Aurum Inst Hlth Res, Klerksdorp, South Africa.
   [Gu, Niya; DiazGranados, Carlos; Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
   [Lee, Carter] Global Solut Infect Dis, San Francisco, CA USA.
   [Swann, Edith] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
   [Kim, Jerome; O'Connell, Robert; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
   [DeRosa, Steve; Frahm, Nicole; McElrath, Julie] Fred Hutchinson Canc Res Ctr, HVTN Lab Program, Seattle, WA 98104 USA.
   [Morris, Lynn] NHLS, Natl Inst Communicable Dis, Johannesburg, South Africa.
   [Montefiori, David; Tomaras, Georgia] Duke Univ, Human Vaccine Inst, Durham, NC USA.
   [Montefiori, David; Tomaras, Georgia] Duke Univ, Sch Med, Ctr HIV AIDS Vaccine Immunol, Durham, NC USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 6
Z9 6
U1 5
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA11.06 LB
BP A33
EP A34
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400067
ER

PT J
AU Hay, CM
   Wilson, GJ
   Elizaga, M
   Li, S
   Kochar, N
   Allen, M
   Sobieszczyk, M
   Frank, I
   Frahm, N
   Tomaras, GD
   Egan, M
   Pensiero, M
   Eldridge, J
AF Hay, Christine M.
   Wilson, Gregory J.
   Elizaga, Marnie
   Li, Sue
   Kochar, Nidhi
   Allen, Mary
   Sobieszczyk, Magdalena
   Frank, Ian
   Frahm, Nicole
   Tomaras, Georgia D.
   Egan, Michael
   Pensiero, Michael
   Eldridge, John
CA NIAID HIV Vaccine Trials Network
TI An HIV DNA Vaccine Delivered by Electroporation and Boosted by rVSV
   HIV-1 Gag Is Safe and Immunogenic in Healthy HIV-uninfected Adults
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Hay, Christine M.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
   [Wilson, Gregory J.] Vanderbilt Univ, Nashville, TN 37235 USA.
   [Elizaga, Marnie; Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Li, Sue; Kochar, Nidhi] SCHARP FHCRC, Seattle, WA USA.
   [Allen, Mary; Pensiero, Michael] NIAID, DAIDS, NIH, Rockville, MD USA.
   [Sobieszczyk, Magdalena] Columbia Univ, New York, NY USA.
   [Frank, Ian] Univ Penn, Philadelphia, NY USA.
   [Tomaras, Georgia D.] Duke Univ, Durham, NC USA.
   [Egan, Michael; Eldridge, John] Profectus Biosci, Tarrytown, NY USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 1
Z9 1
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA05.02
BP A17
EP A17
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400027
ER

PT J
AU Hensley-McBain, T
   Richert-Spuhler, LE
   Koday, M
   Gile, J
   Keele, BF
   Estes, JD
   Klatt, NR
AF Hensley-McBain, Tiffany
   Richert-Spuhler, Laura E.
   Koday, Michael
   Gile, Jillian
   Keele, Brandon F.
   Estes, Jacob D.
   Klatt, Nichole R.
TI Dysfunctional Neutrophil Responses to SIV Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Hensley-McBain, Tiffany; Richert-Spuhler, Laura E.; Koday, Michael; Gile, Jillian; Klatt, Nichole R.] Univ Washington, Dept Pharmaceut, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA.
   [Keele, Brandon F.; Estes, Jacob D.] SAIC Frederick Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P12.05
BP A125
EP A126
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401122
ER

PT J
AU Herold, BC
   Kelly, C
   Chen, B
   Salata, R
   Marzinke, M
   Dezzutti, C
   Levy, L
   Burzuk, BG
   Piper, J
   McGowan, I
   Hendrix, CW
AF Herold, Betsy C.
   Kelly, Cliff
   Chen, Beatrice
   Salata, Robert
   Marzinke, Mark
   Dezzutti, Charlene
   Levy, Lisa
   Burzuk, Beth Galaska
   Piper, Jeanna
   McGowan, Ian
   Hendrix, Craig W.
CA MTN 011
TI Sex Matters: MTN-011 Phase 1 Study on the Impact of Sex on Tenofovir Gel
   Pharmacokinetics (PK) and Pharmacodynamics (PD)
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Herold, Betsy C.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Kelly, Cliff] Fred Hutchinson Canc Res Ctr, SCHARP Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA.
   [Chen, Beatrice; Dezzutti, Charlene] Magee Womens Res Inst, Pittsburgh, PA USA.
   [Salata, Robert] Case Western Reserve Univ, Sch Dent Med, Cleveland, OH 44106 USA.
   [Marzinke, Mark; Hendrix, Craig W.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Levy, Lisa] Family Hlth Int, Washington, DC USA.
   [Burzuk, Beth Galaska; McGowan, Ian] Magee Women Res Inst, Pittsburgh, PA USA.
   [Piper, Jeanna] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA13.05 LB
BP A38
EP A38
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400078
ER

PT J
AU Huang, JH
   Kang, B
   Wheatley, A
   Narpala, S
   Mcdermott, A
   Poole, A
   Bailer, R
   Koup, R
   Migueles, S
   Gurwith, M
   Connors, M
AF Huang, Jinghe
   Kang, Byong
   Wheatley, Adam
   Narpala, Sandeep
   Mcdermott, Adrian
   Poole, April
   Bailer, Robert
   Koup, Richard
   Migueles, Stephen
   Gurwith, Marc
   Connors, Mark
TI Live Adenovirus Type 4 Recombinants Induce Durable Neutralizing Antibody
   Responses to Influenza H5 with High Levels of Somatic Hypermutation in
   Humans
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Huang, Jinghe; Kang, Byong; Poole, April; Migueles, Stephen; Connors, Mark] NIAID, LIR, HIV Specif Immun Sect, Bethesda, MD 20892 USA.
   [Wheatley, Adam; Narpala, Sandeep; Mcdermott, Adrian; Bailer, Robert; Koup, Richard] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Gurwith, Marc] PaxVax Inc, La Jolla, CA USA.
RI Huang, Jinghe/O-1986-2015
NR 0
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA16.01
BP A44
EP A44
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400092
ER

PT J
AU Joag, VR
   McKinnon, LR
   Kidane, S
   Yudin, M
   Kimwaki, S
   Rainwater, S
   Overbaugh, J
   Anzala, O
   Arthos, J
   Kimani, J
   Kaul, R
AF Joag, Vineet R.
   McKinnon, Lyle R.
   Kidane, Segen
   Yudin, Mark
   Kimwaki, Steve
   Rainwater, Stephanie
   Overbaugh, Julie
   Anzala, Omu
   Arthos, James
   Kimani, Joshua
   Kaul, Rupert
TI Preferential HIV Susceptibility of Specific CD4+T Cell Subsets in the
   Cervix
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Joag, Vineet R.; McKinnon, Lyle R.; Kidane, Segen; Yudin, Mark; Kaul, Rupert] Univ Toronto, Toronto, ON, Canada.
   [McKinnon, Lyle R.] CAPRISA, Durban, South Africa.
   [Kimwaki, Steve; Anzala, Omu; Kimani, Joshua; Kaul, Rupert] Univ Nairobi, Nairobi, Kenya.
   [Rainwater, Stephanie; Overbaugh, Julie] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA.
   [Anzala, Omu] Univ Nairobi, Kenya AIDS Vaccine Initiat, Nairobi, Kenya.
   [Arthos, James] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA17.03
BP A47
EP A47
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400100
ER

PT J
AU Kabwigu, S
   Noguchi, L
   Moodley, J
   Palanee, T
   Kintu, K
   Nair, L
   Panchia, R
   Selepe, P
   Balkus, JE
   Torjesen, K
   Piper, J
   Scheckter, R
   Hazra, R
   Beigi, R
AF Kabwigu, Samuel
   Noguchi, Lisa
   Moodley, Jothi
   Palanee, Thes
   Kintu, Kenneth
   Nair, Lulu
   Panchia, R.
   Selepe, Pearl
   Balkus, Jennifer E.
   Torjesen, Kristine
   Piper, Jeanna
   Scheckter, Rachel
   Hazra, Rohan
   Beigi, Richard
TI The MTN-016 Pregnancy Registry: Baseline Characteristics of Enrollees
   from the VOICE Study and Reasons for Non-enrollment of Eligible Women
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Kabwigu, Samuel; Kintu, Kenneth] MU JHU Res Collaborat, Kampala, Uganda.
   [Noguchi, Lisa] Johns Hopkins Univ, MTN, Baltimore, MD USA.
   [Moodley, Jothi] MRC, Durban, South Africa.
   [Palanee, Thes] Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa.
   [Nair, Lulu] CAPRISA, Durban, South Africa.
   [Panchia, R.] PHRU, Soweto, South Africa.
   [Selepe, Pearl] Aurum Inst, Klerksdorp, South Africa.
   [Balkus, Jennifer E.] FHCRC, Seattle, WA USA.
   [Balkus, Jennifer E.] Univ Washington, Seattle, WA 98195 USA.
   [Torjesen, Kristine; Scheckter, Rachel] FHI 360, Durham, NC USA.
   [Piper, Jeanna] US NIH, DAIDS, Bethesda, MD USA.
   [Hazra, Rohan] NICHD, US NIH, Bethesda, MD USA.
   [Beigi, Richard] Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15213 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P45.05
BP A267
EP A267
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403142
ER

PT J
AU Karamov, E
   Kornilaeva, G
   Alexandre, K
   O'Keefe, B
   Moog, C
   McGowan, I
   Doncel, G
   Zalenskaya, I
   Turgiev, A
   Tatarintsev, A
AF Karamov, Eduard
   Kornilaeva, Galina
   Alexandre, Kabamba
   O'Keefe, Barry
   Moog, Christiane
   McGowan, Ian
   Doncel, Gustavo
   Zalenskaya, Irina
   Turgiev, Ali
   Tatarintsev, Alexander
TI Humic Acids (HA) Strongly Potentiate Anti-HIV Effects of AZT,
   Griffithsin, and Cyanovirin
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Karamov, Eduard; Kornilaeva, Galina] Ivanovsky Inst Virol, Moscow, Russia.
   [Karamov, Eduard; Turgiev, Ali; Tatarintsev, Alexander] Immunomica LLC, Moscow, Russia.
   [Alexandre, Kabamba; O'Keefe, Barry] NCI, Ctr Canc Res, Frederick, MD 21701 USA.
   [Moog, Christiane] Strasbourg Univ, Strasbourg, France.
   [McGowan, Ian] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
   [McGowan, Ian] Magee Women Res Inst, Pittsburgh, PA USA.
   [Doncel, Gustavo; Zalenskaya, Irina] CONRAD, Eastern Virginia Med Sch, Norfolk, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P33.03
BP A204
EP A204
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402154
ER

PT J
AU Karuna, ST
   Grove, D
   Broder, GB
   Anude, C
   Hammer, SM
   Sobieszczyk, ME
   Andrasik, MP
AF Karuna, Shelly T.
   Grove, Doug
   Broder, Gail B.
   Anude, Chuka
   Hammer, Scott M.
   Sobieszczyk, Magda E.
   Andrasik, Michele P.
CA NIAID
TI Transgender Participants in the HIV Vaccine Trial Network's HVTN 505
   Trial: A Descriptive and Comparative Analysis
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Karuna, Shelly T.; Grove, Doug; Broder, Gail B.; Andrasik, Michele P.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Karuna, Shelly T.; Andrasik, Michele P.] HIV Vaccine Trials Network, Clin Dev Unit, Seattle, WA USA.
   [Broder, Gail B.] HIV Vaccine Trials Network, Community Engagement Unit, Seattle, WA USA.
   [Anude, Chuka] NIAID, DAIDS, NIH, Vaccine Clin Res Branch, Washington, DC USA.
   [Hammer, Scott M.; Sobieszczyk, Magda E.] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P26.09
BP A189
EP A189
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402116
ER

PT J
AU Kiweewa, FM
   Noguchi, L
   Richardson, B
   Balkus, J
   Kamira, B
   Gati, BM
   Nakabiito, C
   Ramjee, G
   Palanee, T
   Nair, G
   Selepe, P
   Panchia, R
   Ndase, P
   Livant, E
   Van der Straten, A
   Gomez, K
   Singh, D
   Fowler, MG
   Piper, J
   Chirenje, ZM
   Marrazzo, J
AF Kiweewa, Flavia Matovu
   Noguchi, Lisa
   Richardson, Barbra
   Balkus, Jen
   Kamira, Betty
   Gati, Brenda Mirembe
   Nakabiito, Clemensia
   Ramjee, Gita
   Palanee, Thesla
   Nair, Gonasagrie
   Selepe, Pearl
   Panchia, Ravindre
   Ndase, Patrick
   Livant, Edward
   Van der Straten, Ariane
   Gomez, Kailazarid
   Singh, Devika
   Fowler, Mary Glenn
   Piper, Jeanna
   Chirenje, Zvavahera Mike
   Marrazzo, Jeanne
TI Prevalent and Incident Gonorrhea and Chlamydia Infections among Oral
   Contraceptive and Depot Medroxyprogesterone Acetate Users in MTN-003
   (VOICE)
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Kiweewa, Flavia Matovu; Kamira, Betty; Gati, Brenda Mirembe; Nakabiito, Clemensia; Fowler, Mary Glenn] MU JHU Res Collaborat, Kampala, Uganda.
   [Noguchi, Lisa; Fowler, Mary Glenn] Johns Hopkins Univ, Baltimore, MD USA.
   [Richardson, Barbra; Balkus, Jen] SCHARP FHCRC, Seattle, WA USA.
   [Ramjee, Gita] MRC, Durban, South Africa.
   [Palanee, Thesla] Wits RHI, Johannesburg, South Africa.
   [Nair, Gonasagrie] CAPRISA, Durban, South Africa.
   [Selepe, Pearl] Aurum Inst, Klerksdorp, South Africa.
   [Panchia, Ravindre] PHRU, Soweto, South Africa.
   [Ndase, Patrick; Singh, Devika; Marrazzo, Jeanne] Univ Washington, Seattle, WA 98195 USA.
   [Livant, Edward] Magee Womens Res Inst, Pittsburgh, PA USA.
   [Van der Straten, Ariane] RTI Int, San Francisco, CA USA.
   [Gomez, Kailazarid] FHI 360, Durham, NC USA.
   [Piper, Jeanna] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
   [Chirenje, Zvavahera Mike] UZ UCSF, Harare, Zimbabwe.
NR 0
TC 0
Z9 0
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P49.05
BP A278
EP A278
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403170
ER

PT J
AU Kublin, JG
   Moodie, Z
   Metch, B
   Bekker, LG
   Churchyard, G
   Nchabeleng, M
   Mlisana, K
   Allen, M
   Corey, L
   Gray, G
AF Kublin, James G.
   Moodie, Zoe
   Metch, Barbara
   Bekker, Linda-Gail
   Churchyard, Gavin
   Nchabeleng, Maphoshane
   Mlisana, Koleka
   Allen, Mary
   Corey, Larry
   Gray, Glenda
CA HVTN 503 Study Team
TI Incident Herpes Simplex Virus Type 2 Associated with HIV Infection in
   Phambili
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Kublin, James G.] HIV Vaccine Trials Network, Seattle, WA USA.
   [Moodie, Zoe; Metch, Barbara] FHCRC, SCHARP, Seattle, WA USA.
   [Bekker, Linda-Gail] Univ Cape Town, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa.
   [Churchyard, Gavin] Aurum Inst Hlth Res, Klerksdorp, South Africa.
   [Nchabeleng, Maphoshane] Medunsa HIV Res Unit, Medunsa, South Africa.
   [Mlisana, Koleka] Univ KwaZulu Natal, Durban, South Africa.
   [Allen, Mary] NIAID, DAIDS, NIH, Vaccine Clin Res Branch,Vaccine Res Program, Rockville, MD USA.
   [Corey, Larry] FHCRC, HVTN, Seattle, WA USA.
   [Gray, Glenda] Chris Hani Baragwanath Hosp, Perinatal HIV Res Unit, Soweto, South Africa.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA10.03
BP A29
EP A30
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400058
ER

PT J
AU Kwon, YD
   Georgiev, IS
   Zhang, BS
   McKee, K
   O'Dell, S
   Druz, A
   Shi, W
   Connors, M
   Mascola, JR
   Kwong, PD
AF Kwon, Young Do
   Georgiev, Ivelin S.
   Zhang, Baoshan
   McKee, Krisha
   O'Dell, Sijy
   Druz, Alex
   Shi, Wei
   Connors, Mark
   Mascola, John R.
   Kwong, Peter D.
TI Enhancing the Solubility of HIV-1-neutralizing Antibody 10E8
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Kwon, Young Do; Georgiev, Ivelin S.; Zhang, Baoshan; McKee, Krisha; O'Dell, Sijy; Druz, Alex; Shi, Wei; Mascola, John R.; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Connors, Mark] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
RI Kwon, Young Do/A-6957-2010
NR 0
TC 2
Z9 2
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P15.25
BP A150
EP A150
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402015
ER

PT J
AU Lagenaur, L
   Lee, P
   Parks, T
AF Lagenaur, Laurel
   Lee, Peter
   Parks, Thomas
TI Testing a Fast-dissolving Tablet Containing a Recombinant Live
   Biotherapeutic Product, MucoCept-CVN, in the Non-human Primate Model
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Lagenaur, Laurel] NCI, Bethesda, MD 20892 USA.
   [Lagenaur, Laurel; Lee, Peter; Parks, Thomas] Osel Inc, Mountain View, CA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA18.04
BP A50
EP A50
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400107
ER

PT J
AU Lee, GQ
   Carlson, J
   Brumme, CJ
   Byakwaga, H
   Muzoora, C
   MacMillan, D
   Kinloch, N
   Cobarrubias, K
   Brockman, MA
   Hunt, PW
   Martin, JN
   Carrington, M
   Bangsberg, DR
   Harrigan, PR
   Brumme, ZL
AF Lee, Guinevere Q.
   Carlson, Jonathan
   Brumme, Chanson J.
   Byakwaga, Helen
   Muzoora, Conrad
   MacMillan, Daniel
   Kinloch, Natalie
   Cobarrubias, Kyle
   Brockman, Mark A.
   Hunt, Peter W.
   Martin, Jeff N.
   Carrington, Mary
   Bangsberg, David R.
   Harrigan, P. Richard
   Brumme, Zabrina L.
TI Subtype-Specific HIV-1 Adaptation to Host HLA
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Lee, Guinevere Q.; Brumme, Chanson J.; Brockman, Mark A.; Harrigan, P. Richard; Brumme, Zabrina L.] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada.
   [Carlson, Jonathan] Microsoft Res, Seattle, WA USA.
   [Byakwaga, Helen; Muzoora, Conrad] Mbarara Univ Sci & Technol, Mbarara, Uganda.
   [Byakwaga, Helen; Hunt, Peter W.; Martin, Jeff N.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [MacMillan, Daniel; Kinloch, Natalie; Cobarrubias, Kyle; Brockman, Mark A.; Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada.
   [Carrington, Mary] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA.
   [Bangsberg, David R.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Bangsberg, David R.] Harvard Univ, Sch Med, Boston, MA USA.
   [Harrigan, P. Richard] Univ British Columbia, Dept Med, Vancouver, BC, Canada.
RI Lee, Guinevere/D-4436-2017
OI Lee, Guinevere/0000-0002-9412-886X
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P37.03
BP A218
EP A218
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403014
ER

PT J
AU Lemos, MP
   Lama, JR
   Karuna, S
   De Rosa, SC
   Grant, SP
   Swann, EM
   Ganoza, C
   Montano, SM
   Sanchez, J
   McElrath, J
AF Lemos, Maria P.
   Lama, Javier R.
   Karuna, Shelly
   De Rosa, Stephen C.
   Grant, Shannon P.
   Swann, Edith M.
   Ganoza, Carmela
   Montano, Silvia M.
   Sanchez, Jorge
   McElrath, Juliana
TI Circulating CD4+T-cells Are Transiently Activated Following
   Sigmoidoscopy or Circumcision in MSM at High Risk of HIV Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Lemos, Maria P.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
   [Lama, Javier R.; Ganoza, Carmela; Sanchez, Jorge] Asociac Civil Impacta Salud & Educ, Lima, Peru.
   [Karuna, Shelly; De Rosa, Stephen C.; Grant, Shannon P.; McElrath, Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Swann, Edith M.] NIAID, DAIDS, Bethesda, MD 20892 USA.
   [Montano, Silvia M.] US Naval Med Res Unit 6, Lima, Peru.
   [McElrath, Juliana] Univ Washington, Dept Med, Seattle, WA USA.
   [McElrath, Juliana] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P24.08
BP A176
EP A176
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402084
ER

PT J
AU Levendosky, K
   Mizenina, O
   Kleinbeck, K
   Kizima, L
   Rodriguez, A
   Jean-Pierre, N
   Robbiani, M
   O'Keefe, BR
   Zydowsky, T
   Fernandez-Romero, JA
AF Levendosky, Keith
   Mizenina, Olga
   Kleinbeck, Kyle
   Kizima, Larisa
   Rodriguez, Aixa
   Jean-Pierre, Ninochka
   Robbiani, Melissa
   O'Keefe, Barry R.
   Zydowsky, Thomas
   Fernandez-Romero, Jose A.
TI Antiviral Activity and Mode of Action of Griffithsin against HSV-2 and
   HPV: Preliminary Studies of a Potential non-ARV Combination Microbicide
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Levendosky, Keith; Mizenina, Olga; Kleinbeck, Kyle; Kizima, Larisa; Rodriguez, Aixa; Jean-Pierre, Ninochka; Robbiani, Melissa; Zydowsky, Thomas; Fernandez-Romero, Jose A.] Populat Council, New York, NY 10021 USA.
   [O'Keefe, Barry R.] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P33.02
BP A203
EP A204
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402153
ER

PT J
AU Liao, L
   Trama, AM
   Williams, WB
   Moody, MA
   Vandergrift, N
   Tomaras, GD
   Marshall, DJ
   Gurley, T
   Whitesides, J
   Eudailey, J
   Foulger, A
   Parks, R
   Stolarchuk, C
   Lloyd, KE
   Soderberg, K
   Mascola, JR
   Koup, R
   Corey, L
   Nabel, GB
   Gilber, P
   Morgan, C
   Maenza, J
   Keefer, M
   Hammer, S
   Churchyard, G
   Montefior, DC
   Graham, BS
   Baden, LR
   Kepler, TB
   Haynes, BF
AF Liao, Larry (Huaxin)
   Trama, A. M.
   Williams, W. B.
   Moody, M. A.
   Vandergrift, Nathan
   Tomaras, G. D.
   Marshall, D. J.
   Gurley, T.
   Whitesides, J.
   Eudailey, J.
   Foulger, A.
   Parks, R.
   Stolarchuk, C.
   Lloyd, K. E.
   Soderberg, K.
   Mascola, J. R.
   Koup, R.
   Corey, L.
   Nabel, G. B.
   Gilber, P.
   Morgan, C.
   Maenza, J.
   Keefer, M.
   Hammer, S.
   Churchyard, G.
   Montefior, D. C.
   Graham, B. S.
   Baden, L. R.
   Kepler, T. B.
   Haynes, B. F.
TI Role of Intestinal Microbiota in Shaping the B Cell Repertoire in HIV
   Infection and Env Vaccination
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Liao, Larry (Huaxin); Trama, A. M.; Williams, W. B.; Moody, M. A.; Vandergrift, Nathan; Tomaras, G. D.; Marshall, D. J.; Gurley, T.; Whitesides, J.; Eudailey, J.; Foulger, A.; Parks, R.; Stolarchuk, C.; Lloyd, K. E.; Soderberg, K.; Montefior, D. C.; Haynes, B. F.] Duke Univ, Med Ctr, Human Vaccine Inst, Durham, NC USA.
   [Mascola, J. R.; Koup, R.; Nabel, G. B.; Graham, B. S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Corey, L.; Morgan, C.; Maenza, J.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA.
   [Gilber, P.] Univ Washington, Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98195 USA.
   [Keefer, M.] Univ Rochester, Med Ctr, Div Infect Dis, Rochester, NY 14642 USA.
   [Hammer, S.] Columbia Univ, Med Ctr, New York, NY USA.
   [Churchyard, G.] Aurum Inst, Johannesburg, South Africa.
   [Baden, L. R.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Kepler, T. B.] Boston Univ, Boston, MA 02215 USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA06.02 LB
BP A19
EP A19
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400033
ER

PT J
AU Liyanage, NPM
   Doster, MN
   Caccuri, F
   Pegu, P
   Gordon, SN
   Parks, RW
   Pise-Masison, C
   Barcena, L
   Scheider, J
   Lakouga, HY
   Kiser, P
   Whitney, S
   Schifanella, L
   Vaccari, M
   Hope, TJ
   Franchini, G
AF Liyanage, Namal P. M.
   Doster, Melvin N.
   Caccuri, Francesca
   Pegu, Poonam
   Gordon, Shari N.
   Parks, Robyn Washington
   Pise-Masison, Cynthia
   Barcena, Luis
   Scheider, Jeff
   Lakouga, Howard Y.
   Kiser, Patrick
   Whitney, Stephen
   Schifanella, Luca
   Vaccari, Monica
   Hope, Thomas J.
   Franchini, Genoveffa
TI Do CD16+NKG2A+NK Cells Recruited to the Gut Combined with Passively
   Administered SIV Specific Antibodies Prevent SIVmac251 Acquisition in
   Macaques?
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Liyanage, Namal P. M.; Doster, Melvin N.; Caccuri, Francesca; Pegu, Poonam; Gordon, Shari N.; Parks, Robyn Washington; Pise-Masison, Cynthia; Schifanella, Luca; Vaccari, Monica; Franchini, Genoveffa] NCI, NIH, Anim Models & Retroviral Vaccine Sect, Bethesda, MD 20892 USA.
   [Barcena, Luis; Scheider, Jeff; Lakouga, Howard Y.; Kiser, Patrick; Hope, Thomas J.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Med Res Ctr Super 303 E, Chicago, IL 60611 USA.
   [Whitney, Stephen] Adv BioSci Labs Inc, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA04.04
BP A15
EP A15
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400023
ER

PT J
AU Lumngwena, EN
   Shuping, L
   Bertniz, N
   Cicala, C
   Arthos, J
   Woodman, Z
AF Lumngwena, Evelyn N.
   Shuping, Liliwe
   Bertniz, Netanya
   Cicala, Claudia
   Arthos, James
   Woodman, Zenda
TI The Role of N-glycosylation in DC-SIGN Interactions with Transmitted
   Founder Variants of HIV-1 Subtype C Envelope
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Lumngwena, Evelyn N.; Shuping, Liliwe; Bertniz, Netanya; Woodman, Zenda] Univ Cape Town, ZA-7925 Cape Town, South Africa.
   [Cicala, Claudia; Arthos, James] NIAID, NIH, Immunoregulat Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P39.06
BP A225
EP A226
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403033
ER

PT J
AU Lynch, RM
   Yamamoto, T
   Wong, P
   Georgiev, I
   Matus-Nicodemos, R
   Schmidt, S
   Gautam, R
   Sheng, ZZ
   Shapiro, L
   Nishimura, Y
   Martin, MA
   Mascola, JR
   Koup, RA
AF Lynch, Rebecca M.
   Yamamoto, Takuya
   Wong, Patrick
   Georgiev, Ivelin
   Matus-Nicodemos, Rodrigo
   Schmidt, Stephen
   Gautam, Rajeev
   Sheng, Zizhang
   Shapiro, Lawrence
   Nishimura, Yoshiaki
   Martin, Malcolm A.
   Mascola, John R.
   Koup, Richard A.
TI Isolation of Monoclonal Antibodies from a SHIV-AD8 Infected Rhesus
   Macaque with Broad Neutralizing Activity
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Lynch, Rebecca M.; Yamamoto, Takuya; Wong, Patrick; Georgiev, Ivelin; Matus-Nicodemos, Rodrigo; Schmidt, Stephen; Mascola, John R.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Gautam, Rajeev; Nishimura, Yoshiaki; Martin, Malcolm A.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Sheng, Zizhang; Shapiro, Lawrence] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA30.05
BP A78
EP A78
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401009
ER

PT J
AU Marrazzo, J
   Rabe, L
   Kelly, C
   Livant, E
   Chirenje, ZM
   Richardson, B
   Dai, J
   Piper, J
   Hillier, S
AF Marrazzo, Jeanne
   Rabe, Lorna
   Kelly, Cliff
   Livant, Edward
   Chirenje, Z. Mike
   Richardson, Barbra
   Dai, James
   Piper, Jeanna
   Hillier, Sharon
CA VOICE Study Team
TI Association of Tenofovir (TFV) Detection with Reduced Risk of Herpes
   Simplex virus Type-2 (HSV-2) Acquisition in the VOICE (MTN 003) Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Marrazzo, Jeanne] Univ Washington, Seattle, WA 98195 USA.
   [Rabe, Lorna; Livant, Edward; Hillier, Sharon] Magee Women Res Inst, Pittsburgh, PA USA.
   [Kelly, Cliff; Richardson, Barbra; Dai, James] SCHARP FHCRC, Seattle, WA USA.
   [Chirenje, Z. Mike] Univ Calif San Francisco Res Programme, Harare, Zimbabwe.
   [Piper, Jeanna] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 1
Z9 1
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA10.06 LB
BP A31
EP A31
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400061
ER

PT J
AU Mason, R
   Adams, C
   Bewley, C
   Mascola, J
   Roederer, M
AF Mason, Rosemarie
   Adams, Cameron
   Bewley, Carole
   Mascola, John
   Roederer, Mario
TI Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mason, Rosemarie; Adams, Cameron; Mascola, John; Roederer, Mario] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Bewley, Carole] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA.
   [Bewley, Carole] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P34.13 LB
BP A211
EP A212
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402175
ER

PT J
AU Mensch, BS
   van der Straten, A
   Hartmann, M
   Cheng, H
   Miller, B
   Piper, J
   Levy, L
   Grossman, C
   Montgomery, E
AF Mensch, Barbara S.
   van der Straten, Ariane
   Hartmann, Miriam
   Cheng, Helen
   Miller, Barbara
   Piper, Jeanna
   Levy, Lisa
   Grossman, Cynthia
   Montgomery, Elizabeth
CA MTN 003D Team
TI Reporting of Challenges to Adherence in VOICE: A Comparison of
   Quantitative and Qualitative Self-reports among Women during and after
   the Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mensch, Barbara S.; Miller, Barbara] Populat Council, New York, NY 10021 USA.
   [van der Straten, Ariane; Hartmann, Miriam; Cheng, Helen; Montgomery, Elizabeth] RTI Int, San Francisco, CA USA.
   [Piper, Jeanna] NIAID, Div Aids, Bethesda, MD 20892 USA.
   [Levy, Lisa] FHI 360, Washington, DC USA.
   [Grossman, Cynthia] NIMH, Ctr Mental Hlth Res AIDS, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P42.04
BP A252
EP A252
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403103
ER

PT J
AU Mensch, BS
   van der Straten, A
   Brown, E
   Liu, K
   Marrazzo, J
   Chirenje, ZM
   Gomez, K
   Piper, J
   Patterson, K
AF Mensch, Barbara S.
   van der Straten, Ariane
   Brown, Elizabeth
   Liu, Karen
   Marrazzo, Jeanne
   Chirenje, Zvavahera Mike
   Gomez, Kailazarid
   Piper, Jeanna
   Patterson, Karen
TI Reporting of Adherence in the VOICE Trial: Does Disclosure of Product
   Non-use Increase at the Termination Visit?
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mensch, Barbara S.] Populat Council, New York, NY 10021 USA.
   [van der Straten, Ariane] RTI Int, San Francisco, CA USA.
   [Brown, Elizabeth; Liu, Karen; Patterson, Karen] SCHARP FHCRC, Seattle, WA USA.
   [Marrazzo, Jeanne] Univ Washington, STD HIV Prevent Training Ctr, Seattle, WA 98195 USA.
   [Chirenje, Zvavahera Mike] UZ UCSF Collaborat Res Programme, Harare, Zimbabwe.
   [Gomez, Kailazarid] FHI 360, Durham, NC USA.
   [Piper, Jeanna] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P42.03
BP A252
EP A252
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403102
ER

PT J
AU Mgodi, NM
   Kelly, CW
   Kakayi, B
   Dai, JY
   Nair, G
   Palanee, T
   Gomez-Feliciano, K
   Marrazzo, J
   Piper, J
   Chirenje, ZM
AF Mgodi, Nyaradzo M.
   Kelly, Cliff W.
   Kakayi, Brenda
   Dai, James Y.
   Nair, Gonasagrie
   Palanee, Thesla
   Gomez-Feliciano, Kailazarid
   Marrazzo, Jeanne
   Piper, Jeanna
   Chirenje, Zvavahera Mike
TI Uptake of HBV Vaccination and Incident HBV Infection in Women of
   Reproductive Age and at Risk of HIV-1 Infection in the VOICE (MTN 003)
   Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mgodi, Nyaradzo M.; Chirenje, Zvavahera Mike] Univ Zimbabwe Univ Calif San Francisco Collaborat, Harare, Zimbabwe.
   [Kelly, Cliff W.; Dai, James Y.] SCHARP FHCRC, Seattle, WA USA.
   [Kakayi, Brenda] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda.
   [Nair, Gonasagrie] Univ KwaZulu Natal, CAPRISA, Durban, South Africa.
   [Palanee, Thesla] Univ Witwatersrand, Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa.
   [Gomez-Feliciano, Kailazarid] FHI 360, Durham, NC USA.
   [Marrazzo, Jeanne] Univ Washington, Seattle, WA 98195 USA.
   [Piper, Jeanna] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P49.06
BP A278
EP A278
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403171
ER

PT J
AU Migueles, SA
   Frahm, N
   Toulmin, SA
   Kelly, EP
   Peterson, BA
   Johnson, SA
   McElrath, MJ
   Connors, M
AF Migueles, Stephen A.
   Frahm, Nicole
   Toulmin, Sushila A.
   Kelly, Elizabeth P.
   Peterson, Bennett A.
   Johnson, Sarah A.
   McElrath, M. J.
   Connors, Mark
TI HIV-Specific CD8+T-cell Expansion Potential, but Not Cytotoxic Capacity,
   Is Associated with Reduced Set Point Viral Loads in Ad5/HIV Vaccinees
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Migueles, Stephen A.; Toulmin, Sushila A.; Kelly, Elizabeth P.; Peterson, Bennett A.; Johnson, Sarah A.; Connors, Mark] NIAID, NIH, Bethesda, MD 20892 USA.
   [Frahm, Nicole; McElrath, M. J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P24.06
BP A175
EP A175
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402082
ER

PT J
AU Mirembe, BG
   Kelly, C
   Nyaradzo, M
   Greenspan, S
   Dai, J
   Bragg, V
   Piper, J
   Akello, CA
   Kiweewa, FM
   Tsitsi, M
   Nakabiito, C
   Riddler, S
AF Mirembe, Brenda G.
   Kelly, Cliff
   Nyaradzo, Mgodi
   Greenspan, Suzan
   Dai, James
   Bragg, Vivian
   Piper, Jeanna
   Akello, Carolyne A.
   Kiweewa, Flavia M.
   Tsitsi, Magure
   Nakabiito, Clemensia
   Riddler, Sharon
TI Bone Mineral Density Changes among Healthy African Pre-menopausal Women
   Participating in a Tenofovir-based HIV PrEP Study: The MTN-003B Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Mirembe, Brenda G.; Akello, Carolyne A.; Kiweewa, Flavia M.; Nakabiito, Clemensia] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda.
   [Kelly, Cliff; Dai, James] SCHARP FHCRC, Seattle, WA USA.
   [Nyaradzo, Mgodi; Tsitsi, Magure] UZ UCSF, Harare, Zimbabwe.
   [Greenspan, Suzan; Riddler, Sharon] Univ Pittsburgh, Pittsburgh, PA USA.
   [Bragg, Vivian] FHI 360, Durham, NC USA.
   [Piper, Jeanna] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P42.05
BP A252
EP A253
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403104
ER

PT J
AU Montgomery, ET
   Noguchi, L
   Dai, J
   Pan, J
   Biggio, J
   Isaacs, K
   Watts, H
   Schwartz, J
   Piper, J
   Beigi, R
AF Montgomery, Elizabeth T.
   Noguchi, Lisa
   Dai, James
   Pan, Jason
   Biggio, Joseph
   Isaacs, Karen
   Watts, Heather
   Schwartz, Jill
   Piper, Jeanna
   Beigi, Richard
TI Tenofovir Gel Acceptability and Adherence among Pregnant Women in the
   United States
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Montgomery, Elizabeth T.] RTI Int, Womens Global Hlth Imperat, Los Angeles, CA USA.
   [Noguchi, Lisa; Beigi, Richard] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
   [Noguchi, Lisa; Beigi, Richard] Magee Women Res Inst, Pittsburgh, PA USA.
   [Dai, James; Pan, Jason] FHCRC, SCHARP, Seattle, WA USA.
   [Biggio, Joseph] Univ Alabama Birmingham, Birmingham, AL USA.
   [Isaacs, Karen] FHI 360, Durham, NC USA.
   [Watts, Heather] NICHD, NIH, Bethesda, MD USA.
   [Schwartz, Jill] EVMS, CONRAD, Arlington, VA USA.
   [Piper, Jeanna] NIAID, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P50.04
BP A282
EP A283
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774404008
ER

PT J
AU Moodie, Z
   Metch, B
   Allen, M
   Bekker, LG
   Churchyard, G
   Nchabeleng, M
   Mlisana, K
   Kublin, J
   Gray, GE
AF Moodie, Zoe
   Metch, Barbara
   Allen, Mary
   Bekker, Linda-Gail
   Churchyard, Gavin
   Nchabeleng, Maphoshane
   Mlisana, Koleka
   Kublin, James
   Gray, Glenda E.
TI Vaccine Enhancement Confirmed among Men in HVTN 503-S, Final Results
   from a Recall Study of Phambili Participants
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Moodie, Zoe; Metch, Barbara; Kublin, James] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Allen, Mary] NIAID, NIH, Vaccine Res Program, Div Aids, Bethesda, MD 20892 USA.
   [Bekker, Linda-Gail] Univ Cape Town, Desmond Tutu HIV Fdn, ZA-7925 Cape Town, South Africa.
   [Churchyard, Gavin] Aurum Inst Hlth Res, Johannesburg, South Africa.
   [Nchabeleng, Maphoshane] Univ Limpopo, MEDUNSA HIV Clin Res Unit, Mankweng E, South Africa.
   [Mlisana, Koleka] Univ KwaZulu Natal, Ctr AIDS Programme Res South Africa, Durban, South Africa.
   [Gray, Glenda E.] Univ Witwatersrand, Perinatal HIV Res Unit, Johannesburg, South Africa.
   [Gray, Glenda E.] South African Med Res Council, Cape Town, South Africa.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA11.04
BP A32
EP A33
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400065
ER

PT J
AU Musara, P
   Munaiwa, O
   Mahaka, I
   Mgodi, NM
   Hartmann, M
   Levy, L
   Montgomery, ET
   Grossmann, CI
   Chirenje, ZM
   van der Straten, A
   Mensch, B
AF Musara, Petina
   Munaiwa, Otillia
   Mahaka, Imelda
   Mgodi, Nyaradzo M.
   Hartmann, Miriam
   Levy, Lisa
   Montgomery, Elizabeth T.
   Grossmann, Cynthia I.
   Chirenje, Zvavahera Mike
   van der Straten, Ariane
   Mensch, Barbara
TI The Effect of Presentation of Pharmacokinetic (PK) Drug Results on
   Self-reported Study Product Adherence among VOICE Participants in
   Zimbabwe
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Musara, Petina; Munaiwa, Otillia; Mgodi, Nyaradzo M.; Chirenje, Zvavahera Mike] Univ Zimbabwe Univ Calif San Francisco Collaborat, Harare, Zimbabwe.
   [Mahaka, Imelda] Univ Zimbabwe, Zimbabwe AIDS Prevent Project, Harare, Zimbabwe.
   [Hartmann, Miriam; Montgomery, Elizabeth T.; van der Straten, Ariane] RTI Int, Womens Global Hlth Imperat, San Francisco, CA USA.
   [Levy, Lisa] FHI 360, Durham, NC USA.
   [Grossmann, Cynthia I.] NIMH, DAIDS, NIH, Bethesda, MD 20892 USA.
   [Mensch, Barbara] Populat Council, New York, NY 10021 USA.
NR 0
TC 2
Z9 2
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA15.03
BP A42
EP A42
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400088
ER

PT J
AU Nawaz, F
   Cicala, C
   Jelicic, K
   Cimbro, R
   Van Ryk, D
   Ray, J
   Hiatt, J
   Schwing, C
   Wei, DL
   Pascuccio, M
   Ansari, AA
   Fauci, AS
   Arthos, J
AF Nawaz, Fatima
   Cicala, Claudia
   Jelicic, Katija
   Cimbro, Raffaello
   Van Ryk, Donald
   Ray, Jocelyn
   Hiatt, Joseph
   Schwing, Catherine
   Wei, Danlan
   Pascuccio, Massimiliano
   Ansari, Aftab A.
   Fauci, Anthony S.
   Arthos, James
TI Functional Dynamics of the Interaction between HIV gp120 and alpha 4
   beta 7
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Nawaz, Fatima; Cicala, Claudia; Jelicic, Katija; Van Ryk, Donald; Ray, Jocelyn; Hiatt, Joseph; Schwing, Catherine; Wei, Danlan; Pascuccio, Massimiliano; Fauci, Anthony S.; Arthos, James] NIAID, NIH, Bethesda, MD 20892 USA.
   [Cimbro, Raffaello] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Ansari, Aftab A.] Emory Univ, Sch Med, Atlanta, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA17.02
BP A46
EP A47
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400099
ER

PT J
AU Nilsson, C
   Hejdeman, B
   Godoy-Ramirez, K
   Tecleab, T
   Scarlatti, G
   Brave, A
   Earl, PL
   Stout, RR
   Robb, ML
   Shattock, R
   Biberfeld, G
   Sandstrom, E
   Wahren, B
AF Nilsson, Charlotta
   Hejdeman, Bo
   Godoy-Ramirez, Karina
   Tecleab, Teghesti
   Scarlatti, Gabriella
   Brave, Andreas
   Earl, Patricia L.
   Stout, Richard R.
   Robb, Merlin L.
   Shattock, Robin
   Biberfeld, Gunnel
   Sandstrom, Eric
   Wahren, Britta
TI Intradermal HIV-DNA Given with or without Intradermal Electroporation Is
   Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Nilsson, Charlotta; Godoy-Ramirez, Karina; Tecleab, Teghesti; Brave, Andreas; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Solna, Sweden.
   [Nilsson, Charlotta; Brave, Andreas; Biberfeld, Gunnel; Wahren, Britta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
   [Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
   [Hejdeman, Bo; Sandstrom, Eric] Sodersjukhuset, Venhalsan, Sweden.
   [Hejdeman, Bo; Sandstrom, Eric] Karolinska Inst, Venhalsan, Sweden.
   [Hejdeman, Bo; Sandstrom, Eric] Dept Educ & Clin Res, Stockholm, Sweden.
   [Scarlatti, Gabriella] IRCCS San Raffaele Sci Inst, Milan, Italy.
   [Earl, Patricia L.] NIAID, NIH, Bethesda, MD 20892 USA.
   [Stout, Richard R.] Bioject Inc, Tualatin, OR USA.
   [Robb, Merlin L.] Walter Reed Army Inst Res, Dept Retrovirol, Rockville, MD USA.
   [Shattock, Robin] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, Div Med, London, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA11.02
BP A31
EP A32
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400063
ER

PT J
AU Noguchi, LM
   Biggio, J
   Bunge, K
   Dai, J
   Isaacs, K
   Torjesen, K
   Kabwigu, S
   Schwartz, J
   Vargas, J
   Scaglia, F
   Jacobson, C
   Watts, DH
   Piper, JM
   Beigi, RH
AF Noguchi, Lisa M.
   Biggio, Joseph
   Bunge, Katherine
   Dai, James
   Isaacs, Karen
   Torjesen, Kristine
   Kabwigu, Samuel
   Schwartz, Jill
   Vargas, Juan
   Scaglia, Fernando
   Jacobson, Cindy
   Watts, D. H.
   Piper, Jeanna M.
   Beigi, Richard H.
CA MTN-002 EMBRACE Study Team
   MTN-008 EMBRACE Study Team
   MTN-016 EMBRACE Study Team
TI Obstetric and Infant Outcomes Following Planned Maternal Third Trimester
   Exposure to Tenofovir 1% Vaginal Gel
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Noguchi, Lisa M.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Noguchi, Lisa M.; Bunge, Katherine; Jacobson, Cindy; Beigi, Richard H.] Microbicide Trials Network, Pittsburgh, PA USA.
   [Biggio, Joseph] Univ Alabama Birmingham, Birmingham, AL USA.
   [Bunge, Katherine; Beigi, Richard H.] Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15213 USA.
   [Dai, James] Stat Ctr HIV AIDS Res & Prevent, Seattle, WA USA.
   [Isaacs, Karen; Torjesen, Kristine] FHI 360, Durham, NC USA.
   [Kabwigu, Samuel] MU JHU Res Collaborat, Kampala, Uganda.
   [Schwartz, Jill] CONRAD EVMS, Arlington, VA USA.
   [Vargas, Juan] UCSF Sch Med, San Francisco Gen Hosp, San Francisco, CA USA.
   [Scaglia, Fernando] Baylor Coll Med, Houston, TX 77030 USA.
   [Watts, D. H.] US Dept State, Off Global AIDS Coordinator, Washington, DC 20520 USA.
   [Piper, Jeanna M.] US NIAID, Div Aids, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P45.07
BP A267
EP A268
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774403144
ER

PT J
AU Palanee, T
   Schwartz, K
   Brown, E
   Govender, V
   Mgodi, N
   Kiweewa, FM
   Nair, G
   Mhlanga, F
   Siva, S
   Bekker, LG
   Gaffoor, Z
   Jeenarain, N
   Naidoo, S
   Martinson, F
   Phillip, J
   Pather, A
   Makhanini, B
   Soto-Torres, L
   Baeten, J
AF Palanee, Thesla
   Schwartz, Katie
   Brown, Elizabeth
   Govender, Vaneshree
   Mgodi, Nyaradzo
   Kiweewa, Flavia Matovu
   Nair, Gonasagrie
   Mhlanga, Felix
   Siva, Samantha
   Bekker, Linda-Gail
   Gaffoor, Zakir
   Jeenarain, Nitesha
   Naidoo, Sarita
   Martinson, Francis
   Phillip, Jessica
   Pather, Arendevi
   Makhanini, Bonus
   Soto-Torres, Lydia
   Baeten, Jared
CA ASPIRE Study Team
TI Baseline Characteristics of HIV-1 Negative Women Enrolled into a
   Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Palanee, Thesla] Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa.
   [Schwartz, Katie] FHI 360, Durham, NC USA.
   [Brown, Elizabeth] SCHARP FHCRC, Seattle, WA USA.
   [Govender, Vaneshree; Siva, Samantha; Gaffoor, Zakir; Jeenarain, Nitesha; Naidoo, Sarita; Phillip, Jessica; Pather, Arendevi] MRC, Durban, South Africa.
   [Mgodi, Nyaradzo; Mhlanga, Felix] Univ Zimbabwe Univ Calif San Francisco Collaborat, Harare, Zimbabwe.
   [Kiweewa, Flavia Matovu] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda.
   [Nair, Gonasagrie] Univ KwaZulu Natal, CAPRISA, Durban, South Africa.
   [Bekker, Linda-Gail] Desmond Tutu HIV Fdn, Cape Town, South Africa.
   [Martinson, Francis] UNC, Lilongwe, Malawi.
   [Makhanini, Bonus] Coll Med John Hopkins Univ Res Project, Blantyre, Malawi.
   [Soto-Torres, Lydia] NIAID, DAIDS, NIH, Washington, DC USA.
   [Baeten, Jared] Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P53.03
BP A289
EP A290
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774404026
ER

PT J
AU Pancera, M
   Druz, A
   Zhou, TQ
   O'Dell, S
   Louder, M
   Madani, N
   Herschhorn, A
   Sodroski, J
   Mascola, JR
   Kwong, PD
AF Pancera, Marie
   Druz, Aliaksandr
   Zhou, Tongqing
   O'Dell, Sijy
   Louder, Mark
   Madani, Navid
   Herschhorn, Alon
   Sodroski, Joseph
   Mascola, John R.
   Kwong, Peter D.
TI Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to
   BG505 SOSIP.664 HIV-1 Env Trimer
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Pancera, Marie; Druz, Aliaksandr; Zhou, Tongqing; O'Dell, Sijy; Louder, Mark; Mascola, John R.; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Madani, Navid; Herschhorn, Alon; Sodroski, Joseph] Dana Farber Canc Inst, Boston, MA 02115 USA.
RI Zhou, Tongqing/A-6880-2010
OI Zhou, Tongqing/0000-0002-3935-4637
NR 0
TC 2
Z9 2
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P15.28 LB
BP A151
EP A151
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402018
ER

PT J
AU Pavlakis, GN
   Li, JY
   Valentin, A
   Jalah, R
   Patel, V
   Rosati, M
   Kulkarni, V
   Alicea, C
   Vargas-Inchaustegui, DA
   Guan, YJ
   Venzon, D
   Sardesai, N
   Fouts, TR
   Pinter, A
   Robert-Guroff, M
   Montefiori, DC
   Shen, XY
   Tomaras, GD
   Felber, BK
AF Pavlakis, George N.
   Li, Jinyao
   Valentin, Antonio
   Jalah, Rashmi
   Patel, Vainav
   Rosati, Margherita
   Kulkarni, Viraj
   Alicea, Candido
   Vargas-Inchaustegui, Diego A.
   Guan, Yongjun
   Venzon, David
   Sardesai, Niranjan
   Fouts, Timothy R.
   Pinter, Abraham
   Robert-Guroff, Marjorie
   Montefiori, David C.
   Shen, Xiaoying
   Tomaras, Georgia D.
   Felber, Barbara K.
TI DNA and Protein Co-immunization Improves the Magnitude, Longevity, and
   Mucosal Dissemination of Immune Responses
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Pavlakis, George N.; Li, Jinyao; Valentin, Antonio; Jalah, Rashmi; Patel, Vainav; Rosati, Margherita; Kulkarni, Viraj; Alicea, Candido; Felber, Barbara K.] NCI, Frederick, MD 21701 USA.
   [Vargas-Inchaustegui, Diego A.; Robert-Guroff, Marjorie] NCI, NIH, Bethesda, MD 20892 USA.
   [Guan, Yongjun] Inst Human Virol, Baltimore, MD USA.
   [Venzon, David] NCI, NIH, Biostat & Data Management Sect, Bethesda, MD 20892 USA.
   [Sardesai, Niranjan] Inovio Pharmaceut Inc, Blue Bell, PA USA.
   [Fouts, Timothy R.] Profectus Biosci Inc, Baltimore, MD USA.
   [Pinter, Abraham] Univ Med & Dent New Jersey, Publ Hlth Res Inst, Newark, NJ 07103 USA.
   [Montefiori, David C.; Shen, Xiaoying; Tomaras, Georgia D.] Duke Univ, Med Ctr, Durham, MD USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA24.04
BP A63
EP A64
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400141
ER

PT J
AU Qian, HZ
   Ruan, YH
   Liu, Y
   Milam, DF
   Spiegel, HML
   Yin, L
   Li, DL
   Shao, YM
   Vermund, SH
AF Qian, Han-Zhu
   Ruan, Yuhua
   Liu, Yu
   Milam, Douglas F.
   Spiegel, Hans M. L.
   Yin, Lu
   Li, Dongliang
   Shao, Yiming
   Vermund, Sten H.
TI Does Circumcision Offer Some Protection from HIV for Men who Have Sex
   with Men? A Cross-sectional Study in China
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Qian, Han-Zhu; Liu, Yu; Milam, Douglas F.; Yin, Lu; Vermund, Sten H.] Vanderbilt Univ, Inst Global Hlth, Nashville, TN 37235 USA.
   [Ruan, Yuhua; Shao, Yiming] China CDC, State Key Lab Infect Dis Prevent & Control, NCAIDS, Beijing, Peoples R China.
   [Spiegel, Hans M. L.] NIAID, NIH, Henry M Jackson Fdn, Div Aids, Bethesda, MD 20892 USA.
   [Li, Dongliang] Chaoyang Dist CDC, Beijing, Peoples R China.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P29.04 LB
BP A197
EP A198
PG 5
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402137
ER

PT J
AU Richert-Spuhler, LE
   Hensley-Mcbain, T
   Gile, J
   Koday, M
   Fuller, DH
   Johnson, B
   Nega, MT
   Appel, C
   Vanderford, T
   Reeves, RK
   Estes, JD
   Keele, BF
   Klatt, NR
AF Richert-Spuhler, Laura E.
   Hensley-Mcbain, Tiffany
   Gile, Jillian
   Koday, Michael
   Fuller, Deborah H.
   Johnson, Brian
   Nega, Melon T.
   Appel, Cara
   Vanderford, Thomas
   Reeves, R. Keith
   Estes, Jacob D.
   Keele, Brandon F.
   Klatt, Nichole R.
TI Rapid Loss of Th17 Cells after SIV Infection May Underlie Mucosal
   Dysfunction
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Richert-Spuhler, Laura E.; Hensley-Mcbain, Tiffany; Gile, Jillian; Koday, Michael; Fuller, Deborah H.; Klatt, Nichole R.] Univ Washington, Seattle, WA 98195 USA.
   [Richert-Spuhler, Laura E.; Hensley-Mcbain, Tiffany; Gile, Jillian; Koday, Michael; Fuller, Deborah H.; Klatt, Nichole R.] Washington Natl Primate Res Ctr, Seattle, WA USA.
   [Johnson, Brian; Appel, Cara] Univ Washington, Dept Comparat Med, HIC Comparat Pathol Program, Seattle, WA 98195 USA.
   [Nega, Melon T.; Vanderford, Thomas] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
   [Reeves, R. Keith] Harvard Univ, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
   [Estes, Jacob D.; Keele, Brandon F.] SAIC Frederick Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA17.05
BP A48
EP A48
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400102
ER

PT J
AU Riddler, S
   Husnik, M
   Pather, A
   Palanee, T
   Nair, G
   Mhlanga, F
   Taljaard, M
   Nakabiito, C
   Premrajh, A
   Levy, L
   Elharrar, V
   Ramjee, G
   Balkus, J
AF Riddler, Sharon
   Husnik, Marla
   Pather, Arendevi
   Palanee, Thesla
   Nair, Gonasagrie
   Mhlanga, Felix
   Taljaard, Marthinette
   Nakabiito, Clemensia
   Premrajh, Anamika
   Levy, Lisa
   Elharrar, Vanessa
   Ramjee, Gita
   Balkus, Jennifer
CA MTN-015 Protocol Team
TI Long-term Follow-up of HIV Seroconverters from the VOICE Trial - An
   Analysis of Data from MTN-015
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Riddler, Sharon] Univ Pittsburgh, Pittsburgh, PA USA.
   [Husnik, Marla] Stat Ctr HIV AIDS Res & Prevent SCHARP, Seattle, WA USA.
   [Pather, Arendevi; Premrajh, Anamika; Ramjee, Gita] MRC, Durban, South Africa.
   [Palanee, Thesla] Univ Witwatersrand, Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa.
   [Nair, Gonasagrie] Univ KwaZulu Natal, CAPRISA, Durban, South Africa.
   [Mhlanga, Felix] Univ Zimbabwe Univ Calif San Francisco Collaborat, Harare, Zimbabwe.
   [Taljaard, Marthinette] Aurum Inst, Klerksdorp, South Africa.
   [Nakabiito, Clemensia] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda.
   [Levy, Lisa] FHI 360, Res Triangle Pk, NC USA.
   [Elharrar, Vanessa] NIH, Div Aids, Bethesda, MD 20892 USA.
   [Balkus, Jennifer] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Balkus, Jennifer] Univ Washington, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P01.02
BP A93
EP A93
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401041
ER

PT J
AU Scheckter, R
   Schwartz, K
   Mayo, A
   Baeten, J
   Palanee, T
   Soto-Torres, L
   Torjesen, K
AF Scheckter, Rachel
   Schwartz, Katie
   Mayo, Ashley
   Baeten, Jared
   Palanee, Thesla
   Soto-Torres, Lydia
   Torjesen, Kristine
TI Managing Communication and Facilitating the Exchange of Ideas in a
   Large, Multi-site Clinical Trial: Experiences from the ASPIRE Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Scheckter, Rachel; Schwartz, Katie; Mayo, Ashley; Torjesen, Kristine] FHI 360, Durham, NC USA.
   [Baeten, Jared] Univ Washington, Seattle, WA 98195 USA.
   [Palanee, Thesla] Wits Reprod Hlth & HIV Inst WRHI, Johannesburg, South Africa.
   [Soto-Torres, Lydia] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P02.01
BP A94
EP A94
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401043
ER

PT J
AU Schifanella, L
   Binello, N
   Vaccari, M
   Gordon, SN
   Caccuri, F
   Blackburn, M
   Doster, M
   Liynage, N
   Pegu, P
   Shen, XY
   Tomaras, GD
   Venzon, D
   Stablien, D
   Barnett, SW
   Barouch, D
   Phogat, S
   Franchini, G
AF Schifanella, Luca
   Binello, Nicolo
   Vaccari, Monica
   Gordon, Shari N.
   Caccuri, Francesca
   Blackburn, Matthew
   Doster, Melvin
   Liynage, Namal
   Pegu, Poonam
   Shen, Xiaoying
   Tomaras, Georgia D.
   Venzon, David
   Stablien, Don
   Barnett, Susan W.
   Barouch, Dan
   Phogat, Sanjay
   Franchini, Genoveffa
TI Plasmablast Phenotype and Mucosal Antibodies to V2 in Vaccine-induced
   Protection Against SIVmac251
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Schifanella, Luca; Binello, Nicolo; Vaccari, Monica; Gordon, Shari N.; Caccuri, Francesca; Blackburn, Matthew; Doster, Melvin; Liynage, Namal; Pegu, Poonam; Franchini, Genoveffa] NCI, NIH, Vaccine Branch, Bethesda, MD 20892 USA.
   [Schifanella, Luca] Univ Milan, Dept Biomed & Clin Sci, Sect Infect Dis & Immunopathol L Sacco, Milan, Italy.
   [Shen, Xiaoying; Tomaras, Georgia D.] Duke Human Vaccine Inst, Durham, NC USA.
   [Venzon, David] NCI, NIH, Biostat & Data Management Sect, Bethesda, MD 20892 USA.
   [Stablien, Don] EMMES Corp, Rockville, MD USA.
   [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA.
   [Barouch, Dan] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
   [Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA06.03
BP A20
EP A20
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400034
ER

PT J
AU Schiller, JT
   Chackerian, B
AF Schiller, John T.
   Chackerian, Bryce
TI Learning from the Success of HPV Vaccines to Develop HIV Vaccines that
   Break B Cell Self-tolerance
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Schiller, John T.] NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA.
   [Chackerian, Bryce] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA PD03.05 LB
BP A85
EP A86
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401025
ER

PT J
AU Schwartz, K
   Ndase, P
   Torjesen, K
   Mayo, A
   Scheckter, R
   van der Straten, A
   Soto-Torres, L
   Palanee, T
   Baeten, J
AF Schwartz, Katie
   Ndase, Patrick
   Torjesen, Kristine
   Mayo, Ashley
   Scheckter, Rachel
   van der Straten, Ariane
   Soto-Torres, Lydia
   Palanee, Thesla
   Baeten, Jared
TI Supporting Participant Adherence through Structured Engagement
   Activities in the MTN-020 (ASPIRE) Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Schwartz, Katie; Torjesen, Kristine; Mayo, Ashley; Scheckter, Rachel] FHI 360, Durham, NC USA.
   [Ndase, Patrick; Baeten, Jared] Univ Washington, Seattle, WA 98195 USA.
   [van der Straten, Ariane] RTI Int, Womens Global Hlth Imperat, San Francisco, CA USA.
   [Soto-Torres, Lydia] NIAID, DAIDS, Bethesda, MD 20892 USA.
   [Palanee, Thesla] Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA PD01.01
BP A80
EP A80
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401011
ER

PT J
AU Sheng, ZZ
   Francica, JR
   Nishimura, Y
   Schmidt, SD
   Lynch, R
   Darko, S
   Zhang, ZH
   Jaeger, F
   Alam, M
   Douek, D
   Mascola, JR
   Martin, MA
   Seder, RA
   Shapiro, L
AF Sheng, Zizhang
   Francica, Joseph R.
   Nishimura, Yoshiaki
   Schmidt, Stephen D.
   Lynch, Rebecca
   Darko, Sam
   Zhang, Zhenhai
   Jaeger, Frederick
   Alam, Munir
   Douek, Daniel
   Mascola, John R.
   Martin, Malcolm A.
   Seder, Robert A.
   Shapiro, Lawrence
TI Longitudinal Antibody Development in SHIVAD8 Infected Non-Human Primate
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Sheng, Zizhang; Zhang, Zhenhai; Shapiro, Lawrence] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA.
   [Francica, Joseph R.; Schmidt, Stephen D.; Lynch, Rebecca; Darko, Sam; Douek, Daniel; Mascola, John R.; Seder, Robert A.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
   [Nishimura, Yoshiaki; Martin, Malcolm A.] NIAID, NIH, Mol Microbiol Lab, Bethesda, MD 20892 USA.
   [Zhang, Zhenhai] Southern Med Univ, Div Nephrol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China.
   [Jaeger, Frederick; Alam, Munir] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P10.12
BP A121
EP A121
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401110
ER

PT J
AU Siskind, R
   Morar, NS
   Campbell, RD
   Schouten, J
AF Siskind, Rona
   Morar, Neetha S.
   Campbell, Russell D.
   Schouten, Jeffrey
TI Implementing Community Involvement in National Institutes of Health
   (NIH) HIV/AIDS Clinical Trials Networks
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Siskind, Rona] NIAID, Div Aids, Workforce Operat Commun & Reporting Branch, Bethesda, MD 20892 USA.
   [Morar, Neetha S.] South African Med Res Council, HIV Prevent Res Unit, Westville, South Africa.
   [Campbell, Russell D.; Schouten, Jeffrey] Fred Hutchinson Canc Res Ctr, Off HIV AIDS Network Coordinat, Seattle, WA 98104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P07.05
BP A107
EP A107
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774401074
ER

PT J
AU Soto, CS
   Ofek, G
   Joyce, MG
   Zhang, BS
   McKee, K
   Mascola, JR
   Kwong, PD
AF Soto, Cinque S.
   Ofek, Gilad
   Joyce, M. Gordon
   Zhang, Baoshan
   McKee, Krisha
   Mascola, John R.
   Kwong, Peter D.
TI Maturation Pathways for the Broad and Potent Antibody 10E8 Using a
   Combination of Next Generation Sequencing, Bioinformatics and Functional
   Analysis
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Soto, Cinque S.; Ofek, Gilad; Joyce, M. Gordon; Zhang, Baoshan; McKee, Krisha; Mascola, John R.; Kwong, Peter D.] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA06.06
BP A21
EP A21
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400037
ER

PT J
AU Ulrich, M
AF Ulrich, Michael
TI HIV and the Law: The Impact of the Law on HIV Research and the Role of
   Researchers
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Ulrich, Michael] NIAID, Henry M Jackson Fdn, Div Aids, NIH, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA P32.03
BP A203
EP A203
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774402151
ER

PT J
AU Vaccari, M
   Gordon, SN
   Fourati, S
   Schifanella, L
   Cameron, M
   Keele, BF
   Shen, XY
   Tomaras, G
   Billings, E
   Rao, M
   Liyanage, NPM
   Vargas-Inchaustegui, DA
   Whitney, S
   Doster, MN
   Binello, N
   Pegu, P
   Montefiori, DC
   Foulds, K
   Quinn, DS
   Donaldson, M
   Liang, F
   Lore, K
   Roederer, M
   Koup, R
   McDermott, A
   Ma, ZM
   Christopher, M
   Phan, TB
   Forthal, DN
   Blackburn, M
   Caccuri, F
   Ferrari, G
   Robert-Guroff, M
   Ratto-Kim, S
   Kim, J
   Michael, N
   Phogat, S
   Barnett, SW
   Tartaglia, J
   Venzon, D
   Stablein, DM
   Sekaly, RP
   Franchini, G
AF Vaccari, Monica
   Gordon, Shari N.
   Fourati, Slim
   Schifanella, Luca
   Cameron, Mark
   Keele, Brandon F.
   Shen, Xiaoying
   Tomaras, Georgia
   Billings, Erik
   Rao, Mangala
   Liyanage, Namal P. M.
   Vargas-Inchaustegui, Diego A.
   Whitney, Steve
   Doster, Melvin N.
   Binello, Nicolo
   Pegu, Poonam
   Montefiori, David C.
   Foulds, Kathryn
   Quinn, David S.
   Donaldson, Mitzi
   Liang, Frank
   Lore, Karin
   Roederer, Mario
   Koup, Richard
   McDermott, Adrian
   Ma, Zhong-Min
   Christopher, Miller
   Phan, Tran B.
   Forthal, Donald N.
   Blackburn, Matthew
   Caccuri, Francesca
   Ferrari, Guido
   Robert-Guroff, Marjorie
   Ratto-Kim, Silvia
   Kim, Jerome
   Michael, Nelson
   Phogat, Sanjay
   Barnett, Susan W.
   Tartaglia, James
   Venzon, David
   Stablein, Donald M.
   Sekaly, Rafick-Pierre
   Franchini, Genoveffa
TI Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine
   Induced Protection from SIVmac251 Acquisition
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Vaccari, Monica; Gordon, Shari N.; Schifanella, Luca; Liyanage, Namal P. M.; Doster, Melvin N.; Binello, Nicolo; Pegu, Poonam; Blackburn, Matthew; Caccuri, Francesca; Franchini, Genoveffa] NCI, Bethesda, MD 20892 USA.
   [Fourati, Slim; Cameron, Mark; Sekaly, Rafick-Pierre] Vaccine & Gene Therapy Inst, Port St Lucie, FL USA.
   [Schifanella, Luca] Univ Milan, Milan, Italy.
   [Keele, Brandon F.] Natl Canc Inst SAIC, AIDS & Canc Virus Program, Frederick, MD USA.
   [Shen, Xiaoying; Tomaras, Georgia] Duke Human Vaccine Inst, Durham, NC USA.
   [Billings, Erik; Rao, Mangala; Pegu, Poonam; Ratto-Kim, Silvia; Kim, Jerome; Michael, Nelson] Walter Reed Army Inst, US Mil HIV Res Program, Silver Spring, MD USA.
   [Vargas-Inchaustegui, Diego A.; Robert-Guroff, Marjorie] NCI, Immune Biol Retroviral Infect Sect, Bethesda, MD 20892 USA.
   [Whitney, Steve] ABL, Rockville, MD USA.
   [Montefiori, David C.; Ferrari, Guido] Duke Univ, Durham, NC USA.
   [Foulds, Kathryn; Quinn, David S.; Donaldson, Mitzi; Liang, Frank; Lore, Karin; Roederer, Mario; Koup, Richard; McDermott, Adrian] Vaccine Res Ctr, Bethesda, MD USA.
   [Ma, Zhong-Min; Christopher, Miller] Calif Natl Primate Res Ctr, Davis, CA USA.
   [Phan, Tran B.; Forthal, Donald N.] Univ Calif Irvine, Sch Med, Irvine, CA 92717 USA.
   [Phogat, Sanjay; Tartaglia, James] Sanofi Pasteur, Swiftwater, IL USA.
   [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA.
   [Venzon, David] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA.
   [Stablein, Donald M.] EMMS Corp, Rockville, MD USA.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 2
Z9 2
U1 1
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA25.01
BP A64
EP A65
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400144
ER

PT J
AU van der Straten, A
   Musara, P
   Etima, J
   Woeber, K
   Montgomery, ET
   Hartmann, M
   Levy, L
   Benny, T
   Cheng, H
   Piper, J
   Grossman, CI
   Mensch, B
AF van der Straten, Ariane
   Musara, Petina
   Etima, Juliane
   Woeber, Kubashni
   Montgomery, Elizabeth T.
   Hartmann, Miriam
   Levy, Lisa
   Benny, Thola
   Cheng, Helen
   Piper, Jeanna
   Grossman, Cynthia I.
   Mensch, Barbara
CA MTN-003D Study Team
TI Disclosure of Pharmacokinetic (PK) Drug Results Promotes Open Discourse
   on Non-adherence among Women in VOICE
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [van der Straten, Ariane; Montgomery, Elizabeth T.; Hartmann, Miriam; Cheng, Helen] RTI Int, Womens Global Hlth Imperat, San Francisco, CA USA.
   [van der Straten, Ariane] Univ Calif San Francisco, Dept Med, CAPS, San Francisco, CA USA.
   [Musara, Petina] UZ UCSF Collaborat Res Programme, Harare, Zimbabwe.
   [Etima, Juliane] Makerere Univ Johns Hopkins Univ Res Collaborat, Kampala, Uganda.
   [Woeber, Kubashni] MRC, Durban, South Africa.
   [Levy, Lisa] FHI 360, Durham, NC USA.
   [Benny, Thola] Desmond Tutu HIV Fdn, Cape Town, South Africa.
   [Piper, Jeanna] NIAID, DAIDS, NIH, Bethesda, MD 20892 USA.
   [Grossman, Cynthia I.] NIMH, NIH, Bethesda, MD 20892 USA.
   [Mensch, Barbara] Populat Council, New York, NY 10021 USA.
NR 0
TC 3
Z9 3
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA15.04
BP A42
EP A43
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400089
ER

PT J
AU Zhang, MY
   Yang, Z
   Li, JJ
   Liu, QS
   Yuan, TT
   Zhang, YY
   Chen, LQ
   Lou, Q
   Yin, HZ
   Dimitrov, DS
AF Zhang, Mei-Yun
   Yang, Zheng
   Li, Jingjing
   Liu, Qingsheng
   Yuan, Tingting
   Zhang, Yanyu
   Chen, Li-Qing
   Lou, Qi
   Yin, Huazhong
   Dimitrov, Dimiter S.
TI Non-HIV-derived (Poly)peptides as Primary Immunogens Followed by
   Envelope Boost Elicit Cross-clade Neutralizing HIV-1 Antibodies
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Symposium on HIV Research for Prevention (HIV R4P)
CY OCT 28-31, 2014
CL Cape Town, SOUTH AFRICA
C1 [Zhang, Mei-Yun; Yang, Zheng; Li, Jingjing; Liu, Qingsheng; Yuan, Tingting; Zhang, Yanyu] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China.
   [Chen, Li-Qing; Lou, Qi; Yin, Huazhong] Zhejiang Acad Med Sci, Hangzhou, Zhejiang, Peoples R China.
   [Dimitrov, Dimiter S.] NCI, NIH, Frederick, MD 21701 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2014
VL 30
SU 1
MA OA16.02
BP A44
EP A44
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AT2OO
UT WOS:000344774400093
ER

PT J
AU Kelly, FL
   Sun, J
   Fischer, BM
   Voynow, JA
   Kummarapurugu, AB
   Zhang, HL
   Nugent, JL
   Beasley, RF
   Martinu, T
   Gwinn, WM
   Morgan, DL
   Palmer, SM
AF Kelly, Francine L.
   Sun, Jesse
   Fischer, Bernard M.
   Voynow, Judith A.
   Kummarapurugu, Apparao B.
   Zhang, Helen L.
   Nugent, Julia L.
   Beasley, Robert F.
   Martinu, Tereza
   Gwinn, William M.
   Morgan, Daniel L.
   Palmer, Scott M.
TI Diacetyl Induces Amphiregulin Shedding in Pulmonary Epithelial Cells and
   in Experimental Bronchiolitis Obliterans
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE amphiregulin; TNF-alpha-converting enzyme; epidermal growth factor
   receptor; diacetyl; bronchiolitis obliterans
ID EGFR LIGANDS; FIBROSIS; WORKERS; LUNG; EXPRESSION; NECROSIS; RATS; MICE
AB Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis. The epidermal growth factor receptor ligand, amphiregulin (AREG), has been implicated in other types of epithelial injury and lung fibrosis. We investigated the effects of DA directly on the pulmonary epithelium, and we hypothesized that DA exposure would result in epithelial cell shedding of AREG. Consistent with this hypothesis, we demonstrate that DA increases AREG by the pulmonary epithelial cell line NCI-H292 and by multiple independent primary human airway epithelial donors grown under physiologically relevant conditions at the air-liquid interface. Furthermore, we demonstrate that AREG shedding occurs through a TNF-alpha-converting enzyme (TACE)-dependent mechanism via inhibition of TACE activity in epithelial cells using the small molecule inhibitor, TNF-alpha protease inhibitor-1, as well as TACE-specific small inhibitor RNA. Finally, we demonstrate supportive in vivo results showing increased AREG transcript and protein levels in the lungs of rodents with DA-induced BO. In summary, our novel in vitro and in vivo observations suggest that further study of AREG is warranted in the pathogenesis of DA-induced BO.
C1 [Kelly, Francine L.; Sun, Jesse; Zhang, Helen L.; Nugent, Julia L.; Beasley, Robert F.; Martinu, Tereza; Palmer, Scott M.] Duke Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, Dept Med, Durham, NC 27710 USA.
   [Fischer, Bernard M.; Voynow, Judith A.; Kummarapurugu, Apparao B.] Duke Univ, Med Ctr, Div Pediat Pulm & Sleep Med, Dept Med, Durham, NC 27710 USA.
   [Gwinn, William M.; Morgan, Daniel L.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Kelly, FL (reprint author), Duke Univ, Med Ctr, Div Pulm & Crit Care Med, 2 Genome Court,DUMC 103002, Durham, NC 27710 USA.
EM fran.kelly@duke.edu
FU Roche Organs Transplant Foundation; National Institutes of Health [R01
   ES016836]; Lung Transplant Foundation [R01 ES016836]; Alpha 1 Foundation
FX This work was supported by the Roche Organs Transplant Foundation and
   the Lung Transplant Foundation, by National Institutes of Health grant
   R01 ES016836 (J.A.V.), and by the Alpha 1 Foundation (B.M.F.).
NR 23
TC 7
Z9 8
U1 1
U2 6
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD OCT
PY 2014
VL 51
IS 4
BP 568
EP 574
DI 10.1165/rcmb.2013-0339OC
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KK
UT WOS:000347418700011
PM 24816162
ER

PT J
AU Chalasani, N
   Bonkovsky, H
   Fontana, R
   Lee, W
   Stolz, A
   Talwalkar, J
   Reddy, R
   Watkins, P
   Navarro, V
   Barnhart, H
   Gu, JZ
   Serrano, J
AF Chalasani, Naga
   Bonkovsky, Herbert
   Fontana, Robert
   Lee, William
   Stolz, Andrew
   Talwalkar, Jay
   Reddy, Rajender
   Watkins, Paul
   Navarro, Victor
   Barnhart, Huiman
   Gu, Jiezhun
   Serrano, Jose
TI Idiosyncratic Drug-Induced Liver Injury (DILI) in the United States: A
   Report of 1,257 Prospectively Enrolled Patients
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 79th Annual Scientific Meeting of the
   American-College-of-Gastroenterology
CY OCT 17-22, 2014
CL Philadelphia, PA
SP Amer Coll Gastroenterol
C1 [Chalasani, Naga] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
   [Bonkovsky, Herbert] Carolinas Hlth Care Syst, Charlotte, NC USA.
   [Fontana, Robert] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Lee, William] UT Southwestern, Dallas, TX USA.
   [Stolz, Andrew] Univ So Calif, Los Angeles, CA USA.
   [Talwalkar, Jay] Mayo Clin, Rochester, MN USA.
   [Reddy, Rajender] Univ Penn, Philadelphia, PA 19104 USA.
   [Watkins, Paul] Univ N Carolina, Chapel Hill, NC USA.
   [Navarro, Victor] Albert Einstein Med Ctr, Philadelphia, PA 19141 USA.
   [Barnhart, Huiman; Gu, Jiezhun] Duke Clin Res Inst, Durham, NC USA.
   [Serrano, Jose] NIDDK, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2014
VL 109
SU 2
MA 450
BP S135
EP S135
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AS6OR
UT WOS:000344383100450
ER

PT J
AU Patel, S
   Takyar, V
   Trowers, E
AF Patel, Sarah
   Takyar, Varun
   Trowers, Eugene
TI Double Double Toil and Trouble: An Unusual Case of Dysphagia
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 79th Annual Scientific Meeting of the
   American-College-of-Gastroenterology
CY OCT 17-22, 2014
CL Philadelphia, PA
SP Amer Coll Gastroenterol
C1 [Patel, Sarah; Trowers, Eugene] Univ Arizona, Tucson, AZ USA.
   [Takyar, Varun] NIH, NIDDK, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2014
VL 109
SU 2
MA 70
BP S25
EP S25
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AS6OR
UT WOS:000344383100071
ER

PT J
AU Takyar, V
   Singh, N
   Patel, K
   Trowers, E
AF Takyar, Varun
   Singh, Nirmal
   Patel, Krunal
   Trowers, Eugene
TI Low-Residue Diet in Colon Preparation Prior to Screening Colonoscopy: A
   Review of Literature
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 79th Annual Scientific Meeting of the
   American-College-of-Gastroenterology
CY OCT 17-22, 2014
CL Philadelphia, PA
SP Amer Coll Gastroenterol
C1 [Takyar, Varun] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Singh, Nirmal; Patel, Krunal; Trowers, Eugene] Univ Arizona, Med Ctr, Tucson, AZ USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2014
VL 109
SU 2
MA 754
BP S218
EP S219
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AS6OR
UT WOS:000344383100745
ER

PT J
AU Takyar, V
   Patel, K
   Walker, C
   Dominguez, C
   Singh, N
   Kisso, B
   Trowers, E
AF Takyar, Varun
   Patel, Krunal
   Walker, Courtney
   Dominguez, Christian
   Singh, Nirmal
   Kisso, Bassel
   Trowers, Eugene
TI Effects of Low-Residue Diet Prior to Day of Colonoscopy on Bowel
   Preparation Quality
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 79th Annual Scientific Meeting of the
   American-College-of-Gastroenterology
CY OCT 17-22, 2014
CL Philadelphia, PA
SP Amer Coll Gastroenterol
C1 [Patel, Krunal; Walker, Courtney; Dominguez, Christian; Singh, Nirmal; Kisso, Bassel; Trowers, Eugene] Univ Arizona, Med Ctr, Tucson, AZ USA.
   [Takyar, Varun] NIDDK, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2014
VL 109
SU 2
MA 693
BP S201
EP S201
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AS6OR
UT WOS:000344383100684
ER

PT J
AU Jensen, RT
   Ito, T
AF Jensen, Robert T.
   Ito, Tetsuhide
TI MOLECULAR TARGETED THERAPY OF GI NEUROENDOCRINE TUMORS (pNETs,
   CARCINOIDS) AND OVERVIEW
SO ANNALS OF ONCOLOGY
LA English
DT Meeting Abstract
CT 12th Annual Meeting of the Japanese-Society-of-Medical-Oncology
CY JUL 17-19, 2014
CL Fukuoka, JAPAN
SP Japanese Soc Med Oncol
C1 [Jensen, Robert T.] NIDDKD, Cell Biol Sect, Digest Dis Branch, NIH, Bethesda, MD USA.
   [Ito, Tetsuhide] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD OCT
PY 2014
VL 25
SU 5
MA IS2-6
DI 10.1093/annonc/mdu409.4
PG 1
WC Oncology
SC Oncology
GA AX8MN
UT WOS:000347163700030
ER

PT J
AU Aggarwal, R
   Rider, LG
   Ruperto, N
   Bayat, N
   Erman, B
   Feldman, BM
   Huber, AM
   Oddis, CV
   Lundberg, IE
   Amato, AA
   Cooper, RG
   Chinoy, H
   Dastmalchi, M
   Fiorentino, D
   Isenberg, D
   Katz, JD
   Mammen, AL
   de Visser, M
   Ytterberg, SR
   Danko, K
   Villa, L
   Rinaldi, M
   Rockette, H
   Lachenbruch, PA
   Miller, FW
   Vencovsky, J
AF Aggarwal, Rohit
   Rider, Lisa G.
   Ruperto, Nicolino
   Bayat, Nastaran
   Erman, Brian
   Feldman, Brian M.
   Huber, Adam M.
   Oddis, Chester V.
   Lundberg, Ingrid E.
   Amato, Anthony A.
   Cooper, Robert G.
   Chinoy, Hector
   Dastmalchi, Maryam
   Fiorentino, David
   Isenberg, David
   Katz, James D.
   Mammen, Andrew L.
   de Visser, Marianne
   Ytterberg, Steven R.
   Danko, Katalin
   Villa, Luca
   Rinaldi, Mariangela
   Rockette, Howard
   Lachenbruch, Peter A.
   Miller, Frederick W.
   Vencovsky, Jiri
TI A Consensus Hybrid Definition Using a Conjoint Analysis Is the Proposed
   As Response Criteria for Minimal and Moderate Improvement for Adult
   Polymyositis and Dermatomyositis Clincal Trials.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Aggarwal, Rohit; Oddis, Chester V.; Rockette, Howard] Univ Pittsburgh, Pittsburgh, PA USA.
   [Rider, Lisa G.; Bayat, Nastaran; Miller, Frederick W.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Ruperto, Nicolino] Ist Giannina Gaslini, I-16148 Genoa, Italy.
   [Erman, Brian] Social & Sci Syst Inc, Durham, NC USA.
   [Feldman, Brian M.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Huber, Adam M.] IWK Hlth Ctr, Halifax, NS, Canada.
   [Lundberg, Ingrid E.] Karolinska Univ Hosp, Rheumatol Unit, Solna, Sweden.
   [Lundberg, Ingrid E.] Karolinska Inst, Stockholm, Sweden.
   [Amato, Anthony A.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Amato, Anthony A.] Harvard Univ, Sch Med, Boston, MA USA.
   [Cooper, Robert G.] Univ Liverpool, Liverpool L69 3BX, Merseyside, England.
   [Chinoy, Hector] Univ Manchester, Ctr Musculoskeletal Res, Manchester, Lancs, England.
   [Dastmalchi, Maryam] Karolinska Inst, Karolinska Univ Hosp Solna, Stockholm, Sweden.
   [Fiorentino, David] Stanford Univ, Redwood City, CA USA.
   [Isenberg, David] UCL, Arthrit Res UK Ctr Adolescent Rheumatol, London, England.
   [Katz, James D.] NIH, Bethesda, MD 20892 USA.
   [Mammen, Andrew L.] Johns Hopkins Univ, Baltimore, MD USA.
   [de Visser, Marianne] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
   [Ytterberg, Steven R.] Mayo Clin, Rochester, MN USA.
   [Danko, Katalin] Univ Debrecen, H-4012 Debrecen, Hungary.
   [Villa, Luca; Rinaldi, Mariangela] IRCCS Ist G Gaslini, Genoa, Italy.
   [Lachenbruch, Peter A.] NIEHS, NIH, Bethesda, MD USA.
   [Vencovsky, Jiri] Charles Univ Prague, Prague, Czech Republic.
NR 0
TC 2
Z9 2
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 912
BP S404
EP S405
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902019
ER

PT J
AU Andrade, D
   Kim, M
   Blanco, LP
   Karumanchi, SA
   Koo, G
   Redecha, PM
   Kirou, KA
   Alvarez, AM
   Mulla, MJ
   Crow, MK
   Abrahams, V
   Kaplan, MJ
   Salmon, JE
AF Andrade, Danieli
   Kim, Mimi
   Blanco, Luz P.
   Karumanchi, S. Ananth
   Koo, Gloria
   Redecha, Patricia M.
   Kirou, Kyriakos A.
   Alvarez, Angela M.
   Mulla, Melissa J.
   Crow, Mary K.
   Abrahams, Vikki
   Kaplan, Mariana J.
   Salmon, Jane E.
TI Interferon-alpha and Angiogenic Dysregulation in Pregnant Lupus Patients
   Destined for Preeclampsia.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Andrade, Danieli; Koo, Gloria; Redecha, Patricia M.; Kirou, Kyriakos A.; Crow, Mary K.; Salmon, Jane E.] Hosp Special Surg, New York, NY 10021 USA.
   [Kim, Mimi] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Blanco, Luz P.; Kaplan, Mariana J.] NIH, Bethesda, MD 20892 USA.
   [Karumanchi, S. Ananth] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
   [Alvarez, Angela M.; Mulla, Melissa J.; Abrahams, Vikki] Yale Univ, Sch Med, New Haven, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 872
BP S385
EP S385
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901416
ER

PT J
AU Asquith, M
   Lin, P
   Gill, T
   Debelius, J
   Stauffer, P
   Davin, S
   Ackermann, G
   Colbert, RA
   Knight, R
   Rosenbaum, J
AF Asquith, Mark
   Lin, Phoebe
   Gill, Tejpal
   Debelius, Justine
   Stauffer, Patrick
   Davin, Sean
   Ackermann, Gail
   Colbert, Robert A.
   Knight, Rob
   Rosenbaum, James
TI HLA-B27 Expression Shapes the Intestinal Microbiota.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Asquith, Mark; Lin, Phoebe; Stauffer, Patrick; Davin, Sean] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [Gill, Tejpal; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
   [Debelius, Justine; Ackermann, Gail; Knight, Rob] Univ Colorado, Boulder, CO 80309 USA.
   [Rosenbaum, James] Legacy Hosp, Portland, OR USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1919
BP S844
EP S845
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904069
ER

PT J
AU Baldini, C
   Santini, E
   Rossi, C
   Sernissi, F
   Martini, D
   Gallo, A
   Donati, V
   Luciano, N
   Ferro, F
   Alevizos, I
   Solini, A
   Bombardieri, S
AF Baldini, Chiara
   Santini, Eleonora
   Rossi, Chiara
   Sernissi, Francesca
   Martini, Daniela
   Gallo, Alessia
   Donati, Valentina
   Luciano, Nicoletta
   Ferro, Francesco
   Alevizos, Illias
   Solini, Anna
   Bombardieri, Stefano
TI Prognostic Value of the Complex P2X7 Receptor-Inflammasome in Patients
   with Primary Sjogren's Syndrome at Lymphoma Risk.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Baldini, Chiara; Sernissi, Francesca; Martini, Daniela; Luciano, Nicoletta; Ferro, Francesco] Rheumatol Unit, Pisa, Italy.
   [Santini, Eleonora; Rossi, Chiara; Donati, Valentina; Solini, Anna; Bombardieri, Stefano] Univ Pisa, Rheumatol Unit, Pisa, Italy.
   [Gallo, Alessia; Alevizos, Illias] NIDCR, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2981
BP S1303
EP S1303
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384906215
ER

PT J
AU Bhavsar, SV
   Khalidi, NA
   Carette, S
   Cuthbertson, D
   Grayson, PC
   Hoffmann, GS
   Koening, CL
   Langford, CA
   McAlear, C
   Moreland, L
   Monach, PA
   Pagnoux, C
   Seo, P
   Warrington, KJ
   Ytterberg, SR
   Merkel, PA
AF Bhavsar, Sankalp V.
   Khalidi, Nader A.
   Carette, Simon
   Cuthbertson, David
   Grayson, Peter C.
   Hoffmann, Gary S.
   Koening, Curry L.
   Langford, Carol A.
   McAlear, Carol
   Moreland, Larry
   Monach, Paul A.
   Pagnoux, Christian
   Seo, Philip
   Warrington, Kenneth J.
   Ytterberg, Steven R.
   Merkel, Peter A.
TI Venothromboembolism in Large Vessel Vasculitis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Bhavsar, Sankalp V.] McMaster Univ, Div Rheumatol, Hamilton, ON, Canada.
   [Khalidi, Nader A.] McMaster Univ, St Josephs Hosp, Hamilton, ON, Canada.
   [Carette, Simon; Pagnoux, Christian] Univ Toronto, Toronto, ON, Canada.
   [Cuthbertson, David] Univ S Florida, Tampa, FL USA.
   [Grayson, Peter C.] NIH, Bethesda, MD 20892 USA.
   [Hoffmann, Gary S.] Cleveland Clin Fdn, Cleveland, OH 44195 USA.
   [Koening, Curry L.] Univ Utah, Salt Lake City, UT USA.
   [Langford, Carol A.] Cleveland Clin, Ctr Vasculitis Care & Res, Cleveland, OH 44106 USA.
   [McAlear, Carol; Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA.
   [Moreland, Larry] Univ Pittsburgh, Med Ctr, Vasculitis Ctr, Pittsburgh, PA USA.
   [Monach, Paul A.] Boston Univ, Sch Med, Vasculitis Ctr, Boston, MA 02118 USA.
   [Seo, Philip] Johns Hopkins Univ, Johns Hopkins Vasculitis Ctr, Baltimore, MD USA.
   [Warrington, Kenneth J.; Ytterberg, Steven R.] Mayo Clin, Rochester, MN USA.
NR 0
TC 1
Z9 1
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 801
BP S351
EP S351
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901345
ER

PT J
AU Canna, S
   de Jesus, AA
   Gouni, S
   Brooks, S
   Zaal, KJ
   Marrero, B
   Liu, Y
   Dimattia, M
   Sanchez, GAM
   Kim, H
   Chapelle, DC
   Plass, N
   Huang, Y
   Biancotto, A
   Duncan, JA
   Benseler, S
   O'Shea, JJ
   Grom, AA
   Deng, ZM
   Laxer, RM
   Goldbach-Mansky, R
AF Canna, Scott
   de Jesus, Adriana Almeida
   Gouni, Sushanth
   Brooks, Stephen
   Zaal, Kristien J.
   Marrero, Bernadette
   Liu, Yin
   Dimattia, Michael
   Sanchez, Gina A. Montealegre
   Kim, Hanna
   Chapelle, Dawn C.
   Plass, Nicole
   Huang, Yan
   Biancotto, Angelique
   Duncan, J. Alex
   Benseler, Susanne
   O'Shea, John J.
   Grom, Alexei A.
   Deng, Zuoming
   Laxer, Ronald M.
   Goldbach-Mansky, Raphaela
TI NLRC4-Related Macrophage Activation Syndrome (NLRC4-MAS): A Novel
   Primary Autoinflammatory Syndrome Caused By Activating Mutations in
   NLRC4
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Canna, Scott; Gouni, Sushanth; Brooks, Stephen; Zaal, Kristien J.; Marrero, Bernadette; Dimattia, Michael; O'Shea, John J.] NIAMS, NIH, Bethesda, MD USA.
   [de Jesus, Adriana Almeida; Liu, Yin; Sanchez, Gina A. Montealegre; Kim, Hanna; Chapelle, Dawn C.; Plass, Nicole; Huang, Yan; Deng, Zuoming; Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Biancotto, Angelique] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Duncan, J. Alex] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
   [Benseler, Susanne] Univ Calgary, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada.
   [Grom, Alexei A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Laxer, Ronald M.] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 315
BP S134
EP S134
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384900315
ER

PT J
AU Chae, JJ
   Park, YH
   Park, C
   Hwang, IY
   Hoffmann, P
   Kehrl, J
   Aksentijevich, I
   Kastner, DL
AF Chae, Jae Jin
   Park, Yong Hwan
   Park, Chung
   Hwang, Il-Young
   Hoffmann, Patrycja
   Kehrl, John
   Aksentijevich, Ivona
   Kastner, Daniel L.
TI Connecting Two Pathways through Ca2+ Signaling: NLRP3 Inflammasome
   Activation Induced By a Hypermorphic PLCG2 Mutation
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Chae, Jae Jin; Park, Yong Hwan; Hoffmann, Patrycja; Aksentijevich, Ivona; Kastner, Daniel L.] NHGRI, Bethesda, MD 20892 USA.
   [Park, Chung; Hwang, Il-Young; Kehrl, John] NIAID, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
BP S797
EP S798
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384903439
ER

PT J
AU Coit, P
   Yalavarthi, S
   Zhao, WP
   Kaplan, MJ
   Sawalha, AH
AF Coit, Patrick
   Yalavarthi, Sri
   Zhao, Wenpu
   Kaplan, Mariana J.
   Sawalha, Amr H.
TI Epigenome Profiling Reveals Robust Hypomethylation of Interferon
   Signature Genes in Lupus Neutrophils.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Coit, Patrick; Yalavarthi, Sri; Sawalha, Amr H.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Zhao, Wenpu; Kaplan, Mariana J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 77
BP S32
EP S33
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384900078
ER

PT J
AU de Jesus, AA
   Deng, ZM
   Brooks, S
   Liu, Y
   Kim, H
   Sanchez, GAM
   Chapelle, DC
   Huang, Y
   Hashkes, P
   Nasrullayeva, G
   Terreri, MT
   Arabshahi, B
   Punaro, MG
   Moorthy, LN
   Reinhardt, A
   Silva, CA
   Sato, EI
   Lilleby, V
   Fleisher, T
   Goldbach-Mansky, R
AF de Jesus, Adriana Almeida
   Deng, Zuoming
   Brooks, Stephen
   Liu, Yin
   Kim, Hanna
   Sanchez, Gina A. Montealegre
   Chapelle, Dawn C.
   Huang, Yan
   Hashkes, Philip
   Nasrullayeva, Gulnara
   Terreri, Maria Teresa
   Arabshahi, Bita
   Punaro, Marilynn G.
   Moorthy, Lakshmi N.
   Reinhardt, Adam
   Silva, Clovis A.
   Sato, Emilia I.
   Lilleby, Vibke
   Fleisher, Thomas
   Goldbach-Mansky, Raphaela
TI Identification of "autoinflammatory interferonopathies"? a New Class of
   Autoinflammatory Conditions?
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [de Jesus, Adriana Almeida; Deng, Zuoming; Liu, Yin; Kim, Hanna; Sanchez, Gina A. Montealegre; Chapelle, Dawn C.; Huang, Yan; Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Brooks, Stephen] NIAMS, NIH, Bethesda, MD USA.
   [Hashkes, Philip] Shaare Zedek Med Ctr, Jerusalem, Israel.
   [Nasrullayeva, Gulnara] Azerbaijan Med Univ, Baku, Azerbaijan.
   [Terreri, Maria Teresa] Univ Fed Sao Paulo, Sao Paulo, Brazil.
   [Arabshahi, Bita] Inova Fairfax Hosp Children, Fairfax, VA USA.
   [Punaro, Marilynn G.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Moorthy, Lakshmi N.] Rutgers State Univ, Robert Wood Johnson Med Sch, New Brunswick, NJ 08903 USA.
   [Reinhardt, Adam] Childrens Specialty Phys, Omaha, NE USA.
   [Silva, Clovis A.] Univ Sao Paulo, Fac Med, Sao Paulo, Brazil.
   [Sato, Emilia I.] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil.
   [Lilleby, Vibke] Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Rheumatol, N-0027 Oslo, Norway.
   [Fleisher, Thomas] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1898
BP S835
EP S835
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904048
ER

PT J
AU Edwan, JH
   Goldbach-Mansky, R
   Colbert, RA
AF Edwan, Jehad H.
   Goldbach-Mansky, Raphaela
   Colbert, Robert A.
TI STAT3-Mediated Regulation of Mitochondrial Membrane Potential Is
   Critical for NLRP3 Inflammasome Activation
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Edwan, Jehad H.; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
   [Goldbach-Mansky, Raphaela] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1815
BP S797
EP S797
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384903437
ER

PT J
AU Erer, B
   Remmers, EF
   Takeuchi, M
   Satorius, C
   Ustek, D
   Tugal-tutkun, I
   Seyahi, E
   Ozyazgan, Y
   Gul, A
   Kastner, DL
   Ombrello, MJ
AF Erer, Burak
   Remmers, Elaine F.
   Takeuchi, Masaki
   Satorius, Colleen
   Ustek, Duran
   Tugal-tutkun, Ilknur
   Seyahi, Emire
   Ozyazgan, Yilmaz
   Gul, Ahmet
   Kastner, Daniel L.
   Ombrello, Michael J.
TI Evaluation of KIR3DL1/KIR3DS1 Association with Behcet's Disease in
   Turkish Individuals.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Erer, Burak; Remmers, Elaine F.; Takeuchi, Masaki; Satorius, Colleen] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Ustek, Duran] Istanbul Univ, Inst Expt Med, Istanbul, Turkey.
   [Tugal-tutkun, Ilknur; Gul, Ahmet] Istanbul Univ, Istanbul Fac Med, Istanbul, Turkey.
   [Seyahi, Emire] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Ozyazgan, Yilmaz] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Kastner, Daniel L.] NHGRI, Bethesda, MD 20892 USA.
   [Ombrello, Michael J.] NIAMSD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2852
BP S1246
EP S1246
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384906087
ER

PT J
AU Faiq, A
   Farhadi, PN
   Wilkerson, J
   Bayat, N
   Jansen, A
   Rose, K
   Itert, L
   Johnson, A
   Parks, C
   Giannini, EH
   Brunner, HI
   Goldberg, B
   Morris, R
   Miller, FW
   Rider, LG
AF Faiq, Abdullah
   Farhadi, Payam Noroozi
   Wilkerson, Jesse
   Bayat, Nastaran
   Jansen, Anna
   Rose, Kathryn
   Itert, Lukasz
   Johnson, Anne
   Parks, Christine
   Giannini, Edward H.
   Brunner, Hermine I.
   Goldberg, Bob
   Morris, Richard
   Miller, Frederick W.
   Rider, Lisa G.
TI Predictors of Myositis Treatments Received and Associated Treatment
   Responses in Myovision, a National Myositis Patient Registry.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Faiq, Abdullah; Farhadi, Payam Noroozi; Bayat, Nastaran; Miller, Frederick W.; Rider, Lisa G.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Wilkerson, Jesse] Social & Sci Syst Inc, Res Triangle Pk, NC USA.
   [Jansen, Anna] NIEHS, EAG, Bethesda, MD USA.
   [Rose, Kathryn; Morris, Richard] Social & Sci Syst Inc, Durham, NC USA.
   [Itert, Lukasz; Johnson, Anne; Giannini, Edward H.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Parks, Christine] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
   [Brunner, Hermine I.] PRCSG, Cincinnati, OH USA.
   [Goldberg, Bob] Myositis Assoc, Alexandria, VA USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2222
BP S967
EP S968
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904368
ER

PT J
AU Faiq, A
   Farhadi, PN
   Bayat, N
   Chase, M
   Jansen, A
   Malley, K
   Wilkerson, J
   Rose, K
   Co, C
   Itert, L
   Johnson, A
   Morris, R
   Parks, C
   Giannini, EH
   Brunner, HI
   Miller, FW
   Goldberg, B
   Rider, LG
AF Faiq, Abdullah
   Farhadi, Payam Noroozi
   Bayat, Nastaran
   Chase, Mikaela
   Jansen, Anna
   Malley, Karen
   Wilkerson, Jesse
   Rose, Kathryn
   Co, Caroll
   Itert, Lukasz
   Johnson, Anne
   Morris, Richard
   Parks, Christine
   Giannini, Edward H.
   Brunner, Hermine I.
   Miller, Frederick W.
   Goldberg, Bob
   Rider, Lisa G.
TI Epidemiologic and Clinical Features of Patients with Adult and Juvenile
   Dermatomyositis, Polymyositis and Inclusion Body Myositis from
   Myovision, a National Myositis Patient Registry.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Faiq, Abdullah; Farhadi, Payam Noroozi; Bayat, Nastaran; Chase, Mikaela; Jansen, Anna; Miller, Frederick W.; Rider, Lisa G.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Malley, Karen] Malley Res Programming Inc, Bethesda, MD USA.
   [Wilkerson, Jesse] Social & Sci Syst Inc, Res Triangle Pk, NC USA.
   [Rose, Kathryn; Co, Caroll; Morris, Richard] Social & Sci Syst Inc, Durham, NC USA.
   [Itert, Lukasz; Johnson, Anne; Giannini, Edward H.; Brunner, Hermine I.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Parks, Christine] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
   [Goldberg, Bob] Myositis Assoc, Alexandria, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2211
BP S963
EP S963
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904357
ER

PT J
AU Gallo, A
   Tandon, M
   Jang, SI
   Cotrim, AP
   Alevizos, I
AF Gallo, Alessia
   Tandon, Mayank
   Jang, Shyh-Ing
   Cotrim, Ana Paola
   Alevizos, Ilias
TI A Descriptive and Comparative Study of the Transcriptome from Salivary
   Exosomes of Sjogren's Syndrome Patients Using RNA-Seq.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Gallo, Alessia; Cotrim, Ana Paola] NIH, Bethesda, MD 20892 USA.
   [Tandon, Mayank; Jang, Shyh-Ing] NIDCR, Bethesda, MD USA.
   [Alevizos, Ilias] NIDCR, NIH 10 1N110, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 526
BP S229
EP S229
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901071
ER

PT J
AU Giancane, G
   ter Haar, N
   Wulffraat, N
   Vastert, B
   Barron, K
   Hentgen, V
   Kallinich, T
   Ozdogan, H
   Anton, J
   Brogan, P
   Cantarini, L
   Frenkel, J
   Galeotti, C
   Gattorno, M
   Grateau, G
   Hofer, M
   Kone-Paut, I
   Kuemmerle-Deschner, JB
   Lachmann, H
   Simon, A
   Feldman, B
   Uziel, Y
   Ozen, S
AF Giancane, Gabriella
   ter Haar, Nienke
   Wulffraat, Nico
   Vastert, Bas
   Barron, Karyl
   Hentgen, Veronique
   Kallinich, Tilmann
   Ozdogan, Huri
   Anton, Jordi
   Brogan, Paul
   Cantarini, Luca
   Frenkel, Joost
   Galeotti, Caroline
   Gattorno, Marco
   Grateau, Gilles
   Hofer, Michael
   Kone-Paut, Isabelle
   Kuemmerle-Deschner, J. B.
   Lachmann, Helen
   Simon, Anna
   Feldman, Brian
   Uziel, Yosef
   Ozen, Seza
TI Evidence Based Recommendations for Genetic Diagnosis of Familial
   Mediterranean Fever.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Giancane, Gabriella] UMC, Utrecht, Netherlands.
   [ter Haar, Nienke; Vastert, Bas; Frenkel, Joost] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Wulffraat, Nico] Wilhelmina Childrens Hosp UMC, Utrecht, Netherlands.
   [Barron, Karyl] NIH, Bethesda, MD 20892 USA.
   [Hentgen, Veronique] Versailles Hosp, Le Chesnay, France.
   [Kallinich, Tilmann] Univ Med Berlin, Charite, Berlin, Germany.
   [Ozdogan, Huri] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Anton, Jordi] Univ Barcelona, Pediat Rheumatol Unit, Hosp St Joan de Deu, Barcelona, Spain.
   [Brogan, Paul] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Cantarini, Luca] Univ Siena, I-53100 Siena, Italy.
   [Galeotti, Caroline; Kone-Paut, Isabelle] Univ Paris 11, Bicetre Hosp, Paris, France.
   [Gattorno, Marco] Ist Giannina Gaslini, I-16148 Genoa, Italy.
   [Grateau, Gilles] Hop Tenon, F-75970 Paris, France.
   [Hofer, Michael] Ctr Multisite Romand Rhumatol Pediat, Lausanne, Switzerland.
   [Kuemmerle-Deschner, J. B.] Univ Hosp Tuebingen, Tubingen, Germany.
   [Lachmann, Helen] UCL, Sch Med, London W1N 8AA, England.
   [Simon, Anna] Radboudumc, Nijmegen, Netherlands.
   [Feldman, Brian] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Uziel, Yosef] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Ozen, Seza] Hacettepe Univ, Dept Pediat Rheumatol, Ankara, Turkey.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1231
BP S539
EP S540
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902336
ER

PT J
AU Giannelou, A
   Zhou, Q
   Stoffels, M
   Ombrello, A
   Stone, D
   Edwan, JH
   Pelletier, M
   Tsai, WX
   Calvo, K
   Rosenzweig, S
   Barron, K
   Gadina, M
   Aksentijevich, I
   Kastner, DL
AF Giannelou, Angeliki
   Zhou, Qing
   Stoffels, Monique
   Ombrello, Amanda
   Stone, Deborah
   Edwan, Jehad H.
   Pelletier, Martin
   Tsai, Wanxia
   Calvo, Katherine
   Rosenzweig, Sergio
   Barron, Karyl
   Gadina, Massimo
   Aksentijevich, Ivona
   Kastner, Daniel L.
TI TRNT1 Missense Mutations Define a New Periodic Fever Syndrome.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Giannelou, Angeliki] NIAMSD, Bethesda, MD 20892 USA.
   [Zhou, Qing; Stoffels, Monique; Stone, Deborah; Aksentijevich, Ivona; Kastner, Daniel L.] NHGRI, Bethesda, MD 20892 USA.
   [Ombrello, Amanda] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Edwan, Jehad H.; Tsai, Wanxia; Gadina, Massimo] NIAMS, NIH, Bethesda, MD USA.
   [Pelletier, Martin] Autoimmun Branch, Immunoregulat Sect, Bethesda, MD USA.
   [Calvo, Katherine] NIH, Ctr Clin, Bethesda, MD 20892 USA.
   [Rosenzweig, Sergio] NIAID, Bethesda, MD 20892 USA.
   [Barron, Karyl] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 816
BP S358
EP S359
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901360
ER

PT J
AU Gill, T
   Asquith, M
   Brooks, S
   Rosenbaum, JT
   Colbert, RA
AF Gill, Tejpal
   Asquith, Mark
   Brooks, Steve
   Rosenbaum, James T.
   Colbert, Robert A.
TI Analysis of the Gut Transcriptome in HLA-B27 Transgenic Rats By RNA-Seq
   Reveals Prominent Interferon and IL-23/IL-17 Axis Signatures.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Gill, Tejpal; Brooks, Steve; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
   [Asquith, Mark; Rosenbaum, James T.] OHSU, Portland, OR USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 615
BP S270
EP S270
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901159
ER

PT J
AU Gourh, P
   Kim, Y
   Agarwal, SK
   Tan, FK
   Assassi, S
   Martin, J
   Arnett, FC
   Mayes, MD
AF Gourh, Pravitt
   Kim, Yoonhee
   Agarwal, Sandeep K.
   Tan, Filemon K.
   Assassi, Shervin
   Martin, Javier
   Arnett, Frank C.
   Mayes, Maureen D.
TI Gene-Gene Interaction of IRF5 and BLK Polymorphisms in US and Spanish
   Cohorts of Systemic Sclerosis (SSc).
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Gourh, Pravitt; Kim, Yoonhee] NIH, Bethesda, MD 20892 USA.
   [Agarwal, Sandeep K.] Baylor Coll Med, Houston, TX 77030 USA.
   [Tan, Filemon K.; Assassi, Shervin; Arnett, Frank C.; Mayes, Maureen D.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Martin, Javier] IPBLN CSIC, Inst Parasitol & Biomed Lopez Neyra, Armilla, Granada, Spain.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 765
BP S335
EP S336
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901309
ER

PT J
AU Grayson, PC
   Yazici, Y
   Novakovich, E
   Joyal, E
   Goldbach-Mansky, RT
   Sibley, CH
AF Grayson, Peter C.
   Yazici, Yusuf
   Novakovich, Elaine
   Joyal, Elizabeth
   Goldbach-Mansky, Raphaela T.
   Sibley, Cailin H.
TI Treatment of Mucocutaneous Manifestations in Behcet's Disease with
   Anakinra: A Pilot Open-Label Study.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Grayson, Peter C.] NIH, Bethesda, MD 20892 USA.
   [Yazici, Yusuf] NYU, Sch Med, New York, NY USA.
   [Novakovich, Elaine; Joyal, Elizabeth; Goldbach-Mansky, Raphaela T.; Sibley, Cailin H.] NIH, Ctr Clin, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2756
BP S1204
EP S1204
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384905433
ER

PT J
AU Grayson, PC
   Carmona-Rivera, C
   Xu, LJ
   Lim, N
   Asare, A
   Phippard, DJ
   Kaplan, MJ
   Merkel, PA
   Monach, PA
AF Grayson, Peter C.
   Carmona-Rivera, Carmelo
   Xu, Lijing
   Lim, Noha
   Asare, Adam
   Phippard, Deborah J.
   Kaplan, Mariana J.
   Merkel, Peter A.
   Monach, Paul A.
TI The Association of Low-Density Granulocytes with Disease Activity and
   Response to Treatment in ANCA-Associated Vasculitis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Grayson, Peter C.; Carmona-Rivera, Carmelo; Kaplan, Mariana J.] NIH, Bethesda, MD 20892 USA.
   [Xu, Lijing; Lim, Noha; Asare, Adam; Phippard, Deborah J.] Immune Tolerance Network, Bethesda, MD USA.
   [Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA.
   [Monach, Paul A.] Boston Univ, Sch Med, Vasculitis Ctr, Boston, MA 02118 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1862
BP S819
EP S820
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904013
ER

PT J
AU Gujar, B
   Gruber-Baldini, A
   Baumgarten, M
   Hawkes, W
   Nevitt, MC
   Yaffe, K
   Harris, T
   Hochberg, MC
AF Gujar, Bansari
   Gruber-Baldini, Ann
   Baumgarten, Mona
   Hawkes, William
   Nevitt, Michael C.
   Yaffe, Kristine
   Harris, Tamara
   Hochberg, Marc C.
TI Older Adults with Osteoarthritis Do Not Have an Increased Risk of
   Cognitive Impairment.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Gujar, Bansari; Gruber-Baldini, Ann; Baumgarten, Mona; Hawkes, William; Hochberg, Marc C.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Nevitt, Michael C.; Yaffe, Kristine] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Harris, Tamara] NIA, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1288
BP S564
EP S564
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902392
ER

PT J
AU Habers, GEA
   Huber, AM
   Mamyrova, G
   Targoff, I
   Boonacker, C
   van Brussel, M
   Miller, FW
   Rider, LG
   van Royen-Kerkhof, A
AF Habers, G. Esther A.
   Huber, Adam M.
   Mamyrova, Gulnara
   Targoff, Ira
   Boonacker, Chantal
   van Brussel, Marco
   Miller, Frederick W.
   Rider, Lisa G.
   van Royen-Kerkhof, Annet
TI Anti-p155/140 Autoantibodies and Selected Features at Illness Onset Are
   Associated with a Chronic Course of Illness in the Juvenile Idiopathic
   Inflammatory Myopathies
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Habers, G. Esther A.; van Brussel, Marco] Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Child Dev & Exercise Ctr, Utrecht, Netherlands.
   [Huber, Adam M.] IWK Hlth Ctr, Halifax, NS, Canada.
   [Mamyrova, Gulnara] George Washington Univ, Washington, DC USA.
   [Targoff, Ira] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA.
   [Boonacker, Chantal] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [Miller, Frederick W.; Rider, Lisa G.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [van Royen-Kerkhof, Annet] Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Utrecht, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1317
BP S579
EP S579
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902421
ER

PT J
AU Harlow, L
   Gochuico, B
   Rosas, I
   Doyle, T
   Osorio, J
   Travers, T
   Camacho, C
   Oddis, CV
   Ascherman, DP
AF Harlow, Lisa
   Gochuico, Bernadette
   Rosas, Ivan
   Doyle, Tracy
   Osorio, Juan
   Travers, Timothy
   Camacho, Carlos
   Oddis, Chester V.
   Ascherman, Dana P.
TI Anti-Citrullinated Heat Shock Protein 90 Antibodies Identified in
   Bronchoalveolar Lavage Fluid Are a Marker of Lung-Specific Immune
   Responses.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Harlow, Lisa; Ascherman, Dana P.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Gochuico, Bernadette] NIH, Bethesda, MD 20892 USA.
   [Rosas, Ivan; Doyle, Tracy; Osorio, Juan] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Travers, Timothy; Camacho, Carlos; Oddis, Chester V.] Univ Pittsburgh, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 437
BP S186
EP S186
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384900436
ER

PT J
AU Harris-Love, M
   Joe, G
   Davenport, T
   Shrader, J
   McElroy, B
   Rakocevic, G
   Vasconcelos, O
   Dalakas, M
AF Harris-Love, Michael
   Joe, Galen
   Davenport, Todd
   Shrader, Joseph
   McElroy, Beverly
   Rakocevic, Goran
   Vasconcelos, Olavo
   Dalakas, Marinos
TI Construct Validity of the Adult Myopathy Assessment Tool in Individuals
   with Inclusion Body Myositis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Harris-Love, Michael] VA Med Ctr, Washington, DC USA.
   [Joe, Galen; Shrader, Joseph; McElroy, Beverly] NIH, Bethesda, MD 20892 USA.
   [Davenport, Todd] Univ Pacific, Stockton, CA 95211 USA.
   [Rakocevic, Goran; Dalakas, Marinos] Thomas Jefferson Univ, Philadelphia, PA 19107 USA.
   [Vasconcelos, Olavo] Richmond Vet Affairs Med Ctr, Richmond, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2330
BP S1017
EP S1017
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384905008
ER

PT J
AU Hoffmann, P
   Zhou, Q
   Ombrello, A
   Jones, A
   Barham, B
   Aksentijevich, I
   Kastner, DL
AF Hoffmann, Patrycja
   Zhou, Qing
   Ombrello, Amanda
   Jones, Anne
   Barham, Beverly
   Aksentijevich, Ivona
   Kastner, Daniel L.
TI Cryopyrinopathy with a Myeloid-Specific NLRP3 Mutation.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Hoffmann, Patrycja; Aksentijevich, Ivona; Kastner, Daniel L.] NHGRI, Bethesda, MD 20892 USA.
   [Zhou, Qing; Ombrello, Amanda; Jones, Anne; Barham, Beverly] NHGRI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1227
BP S538
EP S538
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902332
ER

PT J
AU Hong, S
   Colbert, RA
AF Hong, Sohee
   Colbert, Robert A.
TI ERAP1 Knockdown Affects HLA-B27 Misfolding and Endoplasmic Reticulum
   Stress in HLA-B27 Transgenic Rat Macrophages.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Hong, Sohee; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 621
BP S272
EP S273
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901165
ER

PT J
AU Hwang, M
   Zhou, XD
   Weisman, MH
   Ward, MM
   Wang, JC
   Gensler, LS
   Zou, HJ
   He, DY
   Brown, MA
   Scheet, P
   Reveille, JD
AF Hwang, Mark
   Zhou, Xiaodong
   Weisman, Michael H.
   Ward, Michael M.
   Wang, Jincun
   Gensler, Lianne S.
   Zou, Hejian
   He, Dongyi
   Brown, Matthew A.
   Scheet, Paul
   Reveille, John D.
TI Shared HLA Class I and II Alleles in Susceptibility to Ankylosing
   Spondylitis Among Three Ethnic Groups.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Hwang, Mark; Zhou, Xiaodong; Reveille, John D.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Weisman, Michael H.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   [Ward, Michael M.] NIAMS, NIH, Bethesda, MD USA.
   [Wang, Jincun; Zou, Hejian] Huashan Hosp, Shanghai, Peoples R China.
   [Gensler, Lianne S.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [He, Dongyi] Shanghai Guanghua Hosp, Shanghai, Peoples R China.
   [Brown, Matthew A.] Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia.
   [Scheet, Paul] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 617
BP S271
EP S271
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901161
ER

PT J
AU Jamalyaria, F
   Ward, MM
   Lee, M
   Gensler, LS
   Dickman, LA
   Rahbar, MH
   Tahanan, A
   Assassi, S
   Weisman, MH
   Reveille, JD
AF Jamalyaria, Farokh
   Ward, Michael M.
   Lee, MinJae
   Gensler, Lianne S.
   Dickman, Laura A.
   Rahbar, Mohammad H.
   Tahanan, Amirali
   Assassi, Shervin
   Weisman, Michael H.
   Reveille, John D.
TI Blacks with As Have Greater Disease Severity Than Whites.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Jamalyaria, Farokh; Lee, MinJae; Dickman, Laura A.; Rahbar, Mohammad H.; Tahanan, Amirali; Assassi, Shervin; Reveille, John D.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Ward, Michael M.] NIAMS, NIH, Bethesda, MD USA.
   [Gensler, Lianne S.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Weisman, Michael H.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 588
BP S258
EP S259
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901132
ER

PT J
AU Jang, SI
   Ong, HL
   Ambudkar, I
   Alevizos, I
AF Jang, Shyh-Ing
   Ong, Hwei Ling
   Ambudkar, Indu
   Alevizos, Illias
TI Calcium-Calcineurin-NFAT Signaling Pathway Regulates AQP5 Expression in
   Primary Salivary Gland Acinar Cells.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Jang, Shyh-Ing; Ong, Hwei Ling; Alevizos, Illias] NIDCR, Bethesda, MD USA.
   [Ambudkar, Indu] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 528
BP S229
EP S230
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901073
ER

PT J
AU Jolly, M
   Sequeira, W
   Hasni, S
   Ali, Z
   Toloza, S
   Bertoli, AM
   Blazevic, I
   Vila, LM
   Moldovan, I
   Torralba, KD
   Goker, B
   Bourre-Tessier, J
   Navarra, S
   Wallace, D
   Weisman, MH
   Clarke, AE
   Mok, CC
AF Jolly, Meenakslii
   Sequeira, Winston
   Hasni, Sarfraz
   Ali, Zulfiqar
   Toloza, Sergio
   Bertoli, Ana M.
   Blazevic, Ivana.
   Vila, Luis M.
   Moldovan, Ioana
   Torralba, Karina D.
   Goker, Berna
   Bourre-Tessier, Josiane
   Navarra, S.
   Wallace, Daniel
   Weisman, Michael H.
   Clarke, Ann E.
   Mok, Chi Chiu
TI Hydroxychloroquine Use Is Associated Independently with Improved Quality
   of Life in Systemic Lupus Erythematosus
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Jolly, Meenakslii] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
   [Sequeira, Winston] Rush Univ, Chicago, IL 60612 USA.
   [Hasni, Sarfraz; Ali, Zulfiqar] NIH, Bethesda, MD 20892 USA.
   [Toloza, Sergio] Hosp San Juan Bautista, San Fernando Valle Catam, Argentina.
   [Bertoli, Ana M.] Inst Reumatol Strusberg, Cordoba, Argentina.
   [Blazevic, Ivana.] Univ Buenos Aires, Buenos Aires, DF, Argentina.
   [Vila, Luis M.] Univ Puerto Rico, San Juan, PR 00936 USA.
   [Moldovan, Ioana] Beaver Med Grp, Redlands, CA USA.
   [Torralba, Karina D.] Univ So Calif, Los Angeles, CA 90089 USA.
   [Goker, Berna] Gazi Univ, Sch Med, Ankara, Turkey.
   [Bourre-Tessier, Josiane] Ctr Hosp Univ Montreal, Div Rheumatol, Montreal, PQ, Canada.
   [Navarra, S.] Univ Santo Tomas Hosp, Manila, Philippines.
   [Wallace, Daniel] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
   [Weisman, Michael H.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   [Clarke, Ann E.] Univ Calgary, Calgary, AB, Canada.
   [Mok, Chi Chiu] Tuen Mun Hosp, Hong Kong, Hong Kong, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 681
BP S297
EP S298
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901225
ER

PT J
AU Kim, H
   Brooks, S
   Liu, Y
   de Jesus, AA
   Sanchez, GAM
   Chapelle, DC
   Plass, N
   Huang, Y
   Goldbach-Mansky, R
AF Kim, Hanna
   Brooks, Steve
   Liu, Yin
   de Jesus, Adriana Almeida
   Sanchez, Gina A. Montealegre
   Chapelle, Dawn C.
   Plass, Nicole
   Huang, Yan
   Goldbach-Mansky, Raphaela
TI Validation of a Novel IFN-Regulated Gene Score As Biomarker in Chronic
   Atypical Neutrophilic Dermatosis with Lipdoystrophy and Elevated
   Temperature (CANDLE) Patients on Baricitinib, a Janus Kinase 1/2
   Inhibitor, a Proof of Concept.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Kim, Hanna; Liu, Yin; de Jesus, Adriana Almeida; Sanchez, Gina A. Montealegre; Chapelle, Dawn C.; Plass, Nicole; Huang, Yan; Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Brooks, Steve] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1896
BP S834
EP S834
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904046
ER

PT J
AU Knight, JS
   Subramanian, V
   O'Dell, AA
   Yalavarthi, S
   Zhao, WP
   Smith, CK
   Hodgin, JB
   Thompson, PR
   Kaplan, MJ
AF Knight, Jason S.
   Subramanian, Venkataraman
   O'Dell, Alexander A.
   Yalavarthi, Srilakshmi
   Zhao, Wenpu
   Smith, Carolyne K.
   Hodgin, Jeffrey B.
   Thompson, Paul Ryan
   Kaplan, Mariana J.
TI Peptidylarginine Deiminase Inhibition Mitigates NET Formation and
   Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone
   MRL/Lpr Mice.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Knight, Jason S.; O'Dell, Alexander A.; Yalavarthi, Srilakshmi; Hodgin, Jeffrey B.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Subramanian, Venkataraman; Thompson, Paul Ryan] Scripps Res Inst, Jupiter, FL USA.
   [Zhao, Wenpu; Smith, Carolyne K.; Kaplan, Mariana J.] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 641
BP S281
EP S281
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901185
ER

PT J
AU Layh-Schmitt, G
   Lu, S
   Navid, F
   Gadina, M
   Colbert, RA
AF Layh-Schmitt, Gerlinde
   Lu, Shjia
   Navid, Fatemeh
   Gadina, Massimo
   Colbert, Robert A.
TI Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role
   of Different Cell Types in the Disease Process of Spondyloarthritis
   Pathogenesis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Layh-Schmitt, Gerlinde; Lu, Shjia; Navid, Fatemeh; Gadina, Massimo; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 609
BP S267
EP S268
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901153
ER

PT J
AU Liao, KP
   Playford, M
   Frits, MA
   Iannaccone, CK
   Coblyn, JS
   Weinblatt, ME
   Shadick, NA
   Mehta, NN
AF Liao, K. P.
   Playford, Martin
   Frits, Michelle A.
   Iannaccone, Christine K.
   Coblyn, Jonathan S.
   Weinblatt, Michael E.
   Shadick, Nancy A.
   Mehta, Nehal N.
TI The Association Between Changes in Inflammation and High Density
   Lipoprotein Cholesterol Efflux Capacity in Rheumatoid Arthritis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Liao, K. P.; Frits, Michelle A.; Iannaccone, Christine K.; Coblyn, Jonathan S.; Weinblatt, Michael E.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Playford, Martin] NHBLI, Bethesda, MD USA.
   [Shadick, Nancy A.] Harvard Univ, Brigham & Womens Hosp, Cambridge, MA 02138 USA.
   [Mehta, Nehal N.] Univ Penn, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2889
BP S1262
EP S1263
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384906124
ER

PT J
AU Liu, Y
   de Jesus, AA
   Marrero, B
   Yang, D
   Sanchez, GAM
   Brooks, S
   Deng, ZM
   Paller, A
   Boehm, M
   Goldbach-Mansky, R
AF Liu, Yin
   de Jesus, Adriana Almeida
   Marrero, Bernadette
   Yang, Dan
   Sanchez, Gina A. Montealegre
   Brooks, Steve
   Deng, Zuoming
   Paller, Amy
   Boehm, Manfred
   Goldbach-Mansky, Raphaela
TI Investigation of the Sting/Interferon Pathway Activation in a Novel
   Vasculopathy and Pulmonary Syndrome
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Liu, Yin; Marrero, Bernadette; Brooks, Steve] NIAMS, NIH, Bethesda, MD USA.
   [de Jesus, Adriana Almeida; Sanchez, Gina A. Montealegre; Deng, Zuoming; Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Yang, Dan; Boehm, Manfred] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Paller, Amy] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1812
BP S795
EP S796
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384903434
ER

PT J
AU Mamyrova, G
   Wu, L
   Huber, A
   Targoff, IN
   Miller, FW
   Rider, LG
AF Mamyrova, Gulnara
   Wu, Lan
   Huber, Adam
   Targoff, Ira N.
   Miller, Frederick W.
   Rider, Lisa G.
TI Illness Onset Features and Misdiagnosis in Juvenile Idiopathic
   Inflammatory Myopathies (JIIM) Differ Among Clinical and Autoantibody
   (Ab) Subgroups
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Mamyrova, Gulnara] George Washington Univ, Washington, DC USA.
   [Wu, Lan; Miller, Frederick W.; Rider, Lisa G.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Huber, Adam] IWK Hlth Ctr, Halifax, NS, Canada.
   [Targoff, Ira N.] Univ Oklahoma, Hlth Sci Ctr, Vet Affairs Med Ctr, Oklahoma City, OK USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1318
BP S579
EP S579
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902422
ER

PT J
AU Mecoli, C
   Wang, F
   Pappas, C
   Grayson, PC
   Cuthbertson, D
   Carette, S
   Pagnoux, C
   Hoffman, GS
   Khalidi, NA
   Koening, CL
   Langford, CA
   McAlear, C
   Monach, PA
   Moreland, LW
   Seo, P
   Specks, U
   Ytterberg, SR
   Feng, R
   Hageman, G
   Merkel, PA
AF Mecoli, Christopher
   Wang, Fan
   Pappas, Christopher
   Grayson, Peter C.
   Cuthbertson, David
   Carette, Simon
   Pagnoux, Christian
   Hoffman, Gary S.
   Khalidi, Nader A.
   Koening, Curry L.
   Langford, Carol A.
   McAlear, Carol
   Monach, Paul A.
   Moreland, Larry W.
   Seo, Philip
   Specks, Ulrich
   Ytterberg, Steven R.
   Feng, Rui
   Hageman, Gregory
   Merkel, Peter A.
TI The Relationship of ARMS2 Genotype with Idiopathic Inflammatory
   Vasculitis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Mecoli, Christopher; Feng, Rui] Univ Penn, Philadelphia, PA 19104 USA.
   [Wang, Fan] Univ Penn, Philadelphia, OK USA.
   [Pappas, Christopher; Hageman, Gregory] Univ Utah Sch Med, Salt Lake City, UT USA.
   [Grayson, Peter C.] NIH, Bethesda, MD 20892 USA.
   [Cuthbertson, David] Univ S Florida, Tampa, FL USA.
   [Carette, Simon; Pagnoux, Christian] Univ Toronto, Toronto, ON, Canada.
   [Hoffman, Gary S.] Cleveland Clin Fdn, Ctr Vasculitis Care & Res, Cleveland, OH 44195 USA.
   [Khalidi, Nader A.] McMaster Univ, St Josephs Hosp, Hamilton, ON, Canada.
   [Koening, Curry L.] Univ Utah, Salt Lake City, UT USA.
   [Langford, Carol A.] Cleveland Clin, Ctr Vasculitis Care & Res, Cleveland, OH 44106 USA.
   [McAlear, Carol; Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA.
   [Monach, Paul A.] Boston Univ Sch Med, Vasculitis Ctr, Boston, MA USA.
   [Moreland, Larry W.] Univ Pittsburgh, Pittsburgh, PA USA.
   [Seo, Philip] Johns Hopkins Univ, Johns Hopkins Vasculitis Ctr, Baltimore, MD USA.
   [Specks, Ulrich; Ytterberg, Steven R.] Mayo Clin, Rochester, MN USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2851
BP S1245
EP S1246
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384906086
ER

PT J
AU Minor, L
   Sikora, K
   Brundidge, AD
   Colbert, RA
   Srinivasalu, H
AF Minor, Lauren
   Sikora, Keith
   Brundidge, April D.
   Colbert, Robert A.
   Srinivasalu, Hemalatha
TI Agreement Between Enthesitis Evaluation By Manual Palpation and
   Dolorimetry in Juvenile Spondyloarthritis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Minor, Lauren; Brundidge, April D.; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
   [Sikora, Keith] NIAMS, NIH, Bethesda, DC USA.
   [Srinivasalu, Hemalatha] Childrens Natl Med Ctr, Washington, DC 20010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 283
BP S120
EP S120
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384900283
ER

PT J
AU Nagaraju, K
   Ghimbovschi, S
   Rayavarapu, S
   Phadke, A
   Rider, LG
   Hoffman, E
   Miller, FW
AF Nagaraju, Kanneboyina
   Ghimbovschi, Svetlana
   Rayavarapu, Sree
   Phadke, Aditi
   Rider, Lisa G.
   Hoffman, Eric
   Miller, Frederick W.
TI Muscle Type I Interferon Gene Expression May Predict Therapeutic
   Responses to Rituximab in Myositis Patients.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Nagaraju, Kanneboyina] Childrens Natl Med Ctr, Washington Dc, DC USA.
   [Ghimbovschi, Svetlana] Childrens Natl Med Ctr, Washington Dc, WA USA.
   [Rayavarapu, Sree; Phadke, Aditi; Hoffman, Eric] Childrens Natl Med Ctr, Washington, DC 20010 USA.
   [Rider, Lisa G.] US Dept HHS, Environm Autoimmun Grp, Program Clin Res, NIEHS,NIH, Bethesda, MD USA.
   [Miller, Frederick W.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2216
BP S965
EP S965
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904362
ER

PT J
AU Neal, DCC
   de Jesus, AA
   Huang, Y
   Liu, Y
   Goldbach-Mansky, R
   Montealegre, G
AF Neal, Dawn C. Chapelle
   de Jesus, Adriana Almeida
   Huang, Yan
   Liu, Yin
   Goldbach-Mansky, Raphaela
   Montealegre, Gina
TI Safety and Efficacy of Rilonacept in Patients with Deficiency of
   Interleukin-1 Receptor Antagonist (DIRA)
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Neal, Dawn C. Chapelle; de Jesus, Adriana Almeida; Montealegre, Gina] NIAMS, NIH, Bethesda, MD USA.
   [Huang, Yan; Liu, Yin; Goldbach-Mansky, Raphaela] NIAMSD, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2285
BP S996
EP S996
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904430
ER

PT J
AU Ogdie, A
   Sehra, S
   Khoury, V
   Jiang, YH
   Rose, S
   Mehta, NN
   Pullman-Mooar, SW
   Alavi, A
   Gelfand, J
   Baker, J
AF Ogdie, Alexis
   Sehra, Shiv
   Khoury, Viviane
   Jiang, Yihui
   Rose, Shawn
   Mehta, Nehal N.
   Pullman-Mooar, Sally W.
   Alavi, Abass
   Gelfand, Joel
   Baker, Joshua
TI Agreement Among FDG-PET/CT, Ultrasound and Physical Examination in
   Patients with Inflammatory Arthritis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Ogdie, Alexis; Sehra, Shiv; Khoury, Viviane; Jiang, Yihui; Mehta, Nehal N.; Pullman-Mooar, Sally W.; Alavi, Abass; Gelfand, Joel; Baker, Joshua] Univ Penn, Philadelphia, PA 19104 USA.
   [Rose, Shawn] NIAMSD, Bethesda, MD 20892 USA.
   [Pullman-Mooar, Sally W.] Philadelphia Vet Hosp, Philadelphia, PA USA.
   [Baker, Joshua] Philadelphia VAMC, Philadelphia, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2140
BP S936
EP S936
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904288
ER

PT J
AU Ombrello, MJ
   Remmers, EF
   Tachmazidou, I
   Grom, A
   Foll, D
   Martini, A
   Gattorno, M
   Ozen, S
   Prahalad, S
   Zeft, AS
   Bohnsack, JF
   Ilowite, NT
   Park, JL
   Mellins, ED
   Russo, RAG
   Len, CA
   de Oliveira, SKF
   Yeung, RSM
   Wedderburn, LR
   Anton, J
   Schwarz, T
   Han, B
   Duerr, RH
   Achkar, JP
   Kamboh, MI
   Kaufman, KM
   Kottyan, LC
   Pinto, D
   Scherer, S
   Alarcon-Riquelme, ME
   Martinez, ED
   Estivill, X
   Gul, A
   Satorius, C
   de Bakker, PIW
   Raychaudhuri, S
   Langefeld, CD
   Thompson, SD
   Zeggini, E
   Thomson, W
   Kastner, DL
   Woo, P
AF Ombrello, Michael J.
   Remmers, Elaine F.
   Tachmazidou, Ioanna
   Grom, Alexei
   Foell, Dirk
   Martini, Alberto
   Gattorno, Marco
   Ozen, Seza
   Prahalad, Sampath
   Zeft, Andrew S.
   Bohnsack, John F.
   Ilowite, Norman T.
   Park, Jane L.
   Mellins, Elizabeth D.
   Russo, Ricardo A. G.
   Len, Claudio A.
   de Oliveira, Sheila K. Feitosa
   Yeung, Rae S. M.
   Wedderburn, Lucy R.
   Anton, Jordi
   Schwarz, Tobias
   Han, Buhm
   Duerr, Richard H.
   Achkar, Jean-Paul
   Kamboh, M. Ilyas
   Kaufman, Kenneth M.
   Kottyan, Leah C.
   Pinto, Dalila
   Scherer, Stephen
   Alarcon-Riquelme, Marta E.
   Martinez, Elisa Docampo
   Estivill, Xavier
   Gul, Ahmet
   Satorius, Colleen
   de Bakker, Paul I. W.
   Raychaudhuri, Soumya
   Langefeld, Carl D.
   Thompson, Susan D.
   Zeggini, Eleftheria
   Thomson, Wendy
   Kastner, Daniel L.
   Woo, Patricia
CA Int Childhood Arthrit Genetics
TI HLA-DRB1*1101, Regulatory Variants of the MHC, and a Regulatory Region
   Near an Intergenic Long Noncoding RNA on Chromosome 1 Are Risk Factors
   for Systemic Juvenile Idiopathic Arthritis.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Ombrello, Michael J.] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Remmers, Elaine F.] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Tachmazidou, Ioanna; Zeggini, Eleftheria] Wellcome Trust Sanger Inst, Cambridge, England.
   [Grom, Alexei; Kottyan, Leah C.; Thompson, Susan D.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Foell, Dirk] Univ Childrens Hosp Muenster, Munster, Germany.
   [Martini, Alberto] Univ Genoa, Genoa, Italy.
   [Gattorno, Marco] Inst Giannina Gaslini, Genoa, Italy.
   [Ozen, Seza] Hacettepe Univ, Dept Pediat Rheumatol, Ankara, Turkey.
   [Prahalad, Sampath] Emory Univ, Sch Med, Atlanta, GA USA.
   [Zeft, Andrew S.; Achkar, Jean-Paul] Cleveland Clin, Cleveland, OH 44106 USA.
   [Bohnsack, John F.] Univ Utah, Salt Lake City, UT USA.
   [Ilowite, Norman T.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Park, Jane L.; Mellins, Elizabeth D.] Stanford Univ, Med Ctr, Stanford, CA 94305 USA.
   [Russo, Ricardo A. G.] Hosp Pediat Garrahan, Buenos Aires, DF, Argentina.
   [Len, Claudio A.] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil.
   [de Oliveira, Sheila K. Feitosa] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil.
   [Yeung, Rae S. M.; Scherer, Stephen] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Wedderburn, Lucy R.] UCL, Inst Child Hlth, London, England.
   [Anton, Jordi] Univ Barcelona, Hosp St Joan de Deu, Pediat Rheumatol Unit, Barcelona, Spain.
   [Schwarz, Tobias] Univ Wurzburg, D-97070 Wurzburg, Germany.
   [Han, Buhm; Raychaudhuri, Soumya] Broad Inst MIT & Harvard, Cambridge, MA USA.
   [Duerr, Richard H.; Kamboh, M. Ilyas] Univ Pittsburgh, Pittsburgh, PA USA.
   [Kaufman, Kenneth M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Kaufman, Kenneth M.] Univ Cincinnati, Cincinnati, OH USA.
   [Pinto, Dalila] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Alarcon-Riquelme, Marta E.] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, Oklahoma City, OK 73104 USA.
   [Martinez, Elisa Docampo] Univ Liege, GIGA, Liege, Belgium.
   [Estivill, Xavier] Ctr Genom Regulat, Barcelona, Spain.
   [Gul, Ahmet] Istanbul Univ, Istanbul Fac Med, Istanbul, Turkey.
   [Satorius, Colleen; Kastner, Daniel L.] NHGRI, Bethesda, MD 20892 USA.
   [de Bakker, Paul I. W.] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Langefeld, Carl D.] Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC USA.
   [Langefeld, Carl D.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA.
   [Thomson, Wendy] Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, England.
   [Woo, Patricia] UCL, London, England.
RI de Bakker, Paul/B-8730-2009; Estivill, Xavier/A-3125-2013; Oliveira,
   Sheila/F-5213-2016
OI de Bakker, Paul/0000-0001-7735-7858; Estivill,
   Xavier/0000-0002-0723-2256; Oliveira, Sheila/0000-0002-2426-716X
NR 0
TC 0
Z9 0
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1900
BP S836
EP S836
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904050
ER

PT J
AU Park, YH
   Kastner, DL
   Crhae, JJ
AF Park, Yong Hwan
   Kastner, Daniel L.
   Crhae, Jae Jin
TI Cofilin-1 Is a ROS Sensor in Regulating the NLRP3 Inflammasome.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Park, Yong Hwan; Kastner, Daniel L.; Crhae, Jae Jin] NHGRI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1194
BP S525
EP S525
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902299
ER

PT J
AU Patterson, SL
   Reveille, JD
   Lee, M
   Ward, MM
   Rahbar, MH
   Brown, MA
   Weisman, MH
   Gensler, LS
AF Patterson, Sarah L.
   Reveille, John D.
   Lee, MinJae
   Ward, Michael M.
   Rahbar, Mohammad H.
   Brown, Matthew A.
   Weisman, Michael H.
   Gensler, Lianne S.
TI Better Outcomes in Ankylosing Spondylitis: The Synergistic Association
   Between Exercise and Tumor Necrosis Factor Inhibitors.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Patterson, Sarah L.; Gensler, Lianne S.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Reveille, John D.; Lee, MinJae; Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Ward, Michael M.] NIAMS, NIH, Bethesda, MD USA.
   [Brown, Matthew A.] Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia.
   [Weisman, Michael H.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 569
BP S250
EP S251
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901113
ER

PT J
AU Ponte, C
   Geraldes, R
   Craven, A
   Judge, A
   Grayson, PC
   Suppiah, R
   Robson, J
   Watts, RA
   Merkel, PA
   Luqmani, R
AF Ponte, Cristina
   Geraldes, Ruth
   Craven, Anthea
   Judge, Andrew
   Grayson, Peter C.
   Suppiah, Ravi
   Robson, Joanna
   Watts, Richard A.
   Merkel, Peter A.
   Luqmani, Raashid
TI Colour Doppler Ultrasonography Findings in Giant Cell Arteritis (GCA)
   and Their Relationship with Clinical Manifestations.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Ponte, Cristina; Craven, Anthea; Judge, Andrew; Robson, Joanna; Luqmani, Raashid] Univ Oxford, Oxford, England.
   [Geraldes, Ruth] Lisbon Acad Med Ctr, Lisbon, Portugal.
   [Grayson, Peter C.] NIH, Bethesda, MD 20892 USA.
   [Suppiah, Ravi] Auckland Dist Hlth Board, Auckland, New Zealand.
   [Watts, Richard A.] Ipswich Hosp, Dept Rheumatol, Ipswich, Suffolk, England.
   [Watts, Richard A.] Univ E Anglia, Ipswich, Suffolk, England.
   [Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 794
BP S348
EP S348
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901338
ER

PT J
AU Presby, M
   Soloski, MJ
   Flynn, JA
   Bingham, CO
   Ward, MM
   Louie, GH
AF Presby, Matthew
   Soloski, Mark J.
   Flynn, John A.
   Bingham, Clifton O., III
   Ward, Michael M.
   Louie, Grant H.
TI Identification of Novel Autoantibodies in Patients with Ankylosing
   Spondylitis Using Human Protein Microarray.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Presby, Matthew; Soloski, Mark J.; Flynn, John A.; Bingham, Clifton O., III; Louie, Grant H.] Johns Hopkins Univ, Baltimore, MD USA.
   [Ward, Michael M.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 608
BP S267
EP S267
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901152
ER

PT J
AU Rider, LG
   Aggarwal, R
   Bayat, N
   Erman, B
   Feldman, BM
   Huber, AM
   Cimaz, R
   Cuttica, RJ
   de Oliveira, SKF
   Lindsley, CB
   Pilkington, CA
   Punaro, MG
   Ravelli, A
   Reed, AM
   Rouster-Stevens, KA
   van Royen-Kerkhof, A
   Villa, L
   Rinaldi, M
   Pistorio, A
   Rockette, H
   Lachenbruch, PA
   Miller, FW
   Vencovsky, J
   Ruperto, N
AF Rider, Lisa G.
   Aggarwal, Rohit
   Bayat, Nastaran
   Erman, Brian
   Feldman, Brian M.
   Huber, Adam M.
   Cimaz, Rolando
   Cuttica, Ruben J.
   Feitosa de Oliveira, Sheila K.
   Lindsley, Carol B.
   Pilkington, Clarissa A.
   Punaro, Marilynn G.
   Ravelli, Angelo
   Reed, Ann M.
   Rouster-Stevens, Kelly A.
   van Royen-Kerkhof, Annet
   Villa, Luca
   Rinaldi, Mariangela
   Pistorio, Angela
   Rockette, Howard
   Lachenbruch, Peter A.
   Miller, Frederick W.
   Vencovsky, Jiri
   Ruperto, Nicolino
TI A Hybrid Conjoint Analysis Model Is Proposed As the Definition of
   Minimal, Moderate and Major Clinical Improvement in Juvenile
   Dermatomyositis Clinical Trials
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Rider, Lisa G.; Bayat, Nastaran; Miller, Frederick W.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Aggarwal, Rohit; Rockette, Howard] Univ Pittsburgh, Pittsburgh, PA USA.
   [Erman, Brian] Social & Sci Syst Inc, Durham, NC USA.
   [Feldman, Brian M.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Huber, Adam M.] IWK Hlth Ctr, Halifax, NS, Canada.
   [Cimaz, Rolando] Univ Florence, Florence, Italy.
   [Cuttica, Ruben J.] Univ Buenos Aires, Hosp Ninos Pedro de Elizalde, Buenos Aires, DF, Argentina.
   [Feitosa de Oliveira, Sheila K.] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil.
   [Lindsley, Carol B.] Univ Kansas City Med Ctr, Kansas City, KS USA.
   [Pilkington, Clarissa A.] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Punaro, Marilynn G.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Ravelli, Angelo] Univ Genoa, Genoa, Italy.
   [Reed, Ann M.] Mayo Clin, Rochester, MN USA.
   [Rouster-Stevens, Kelly A.] Emory Univ, Sch Med, Atlanta, GA USA.
   [van Royen-Kerkhof, Annet] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [Villa, Luca; Rinaldi, Mariangela] IRCCS Ist G Gaslini, Genoa, Italy.
   [Pistorio, Angela; Ruperto, Nicolino] Ist Giannina Gaslini, I-16148 Genoa, Italy.
   [Lachenbruch, Peter A.] NIEHS, NIH, Bethesda, MD USA.
   [Vencovsky, Jiri] Charles Univ Prague, Prague, Czech Republic.
RI Oliveira, Sheila/F-5213-2016
OI Oliveira, Sheila/0000-0002-2426-716X
NR 0
TC 1
Z9 1
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1316
BP S578
EP S578
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902420
ER

PT J
AU Riveros, PP
   Tandon, M
   Kazmi, S
   Gallo, A
   Illei, GG
   Alevizos, I
AF Riveros, Paola Perez
   Tandon, Mayank
   Kazmi, Salman
   Gallo, Alessia
   Illei, Gabor G.
   Alevizos, Illias
TI Downregulation of Microrna-183 in Sjogren's Syndrome Minor Salivary
   Glands. Implications in Control of Ezrin Expression and Salivary Gland
   Function.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Riveros, Paola Perez; Tandon, Mayank] NIDCR, Bethesda, MD USA.
   [Kazmi, Salman; Gallo, Alessia] NIH, Bethesda, MD 20892 USA.
   [Illei, Gabor G.] NIDCR, NIH, Bethesda, MD USA.
   [Alevizos, Illias] NIDCR, NIH 10 1N110, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 530
BP S230
EP S230
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901075
ER

PT J
AU Rothwell, S
   Cooper, RG
   Lundberg, IE
   Miller, FW
   Gregersen, PK
   Vencovsky, J
   Danko, K
   Wedderburn, LR
   Limaye, V
   O'Callaghan, AS
   Hanna, MG
   Machado, P
   Pachman, LM
   Reed, AM
   Rider, LG
   Cobb, J
   Platt, H
   Molberg, O
   Benveniste, O
   Mathiesen, P
   Radstake, T
   Doria, A
   De Bleecker, J
   De Paepe, B
   Maurer, B
   Ollier, WE
   Padyukov, L
   O'Hanlon, TP
   Lee, A
   Chinoy, H
   Lamb, J
AF Rothwell, Simon
   Cooper, Robert G.
   Lundberg, Ingrid E.
   Miller, Frederick W.
   Gregersen, Peter K.
   Vencovsky, Jiri
   Danko, Katalin
   Wedderburn, Lucy R.
   Limaye, Vidya
   Selva O'Callaghan, Albert
   Hanna, Michael G.
   Machado, Pedro
   Pachman, Lauren M.
   Reed, Ann M.
   Rider, Lisa G.
   Cobb, Joanna
   Platt, Hazel
   Molberg, Oyvind
   Benveniste, Olivier
   Mathiesen, Pernille
   Radstake, Timothy
   Doria, Andrea
   De Bleecker, Jan
   De Paepe, Boel
   Maurer, Britta
   Ollier, William E.
   Padyukov, Leonid
   O'Hanlon, Terrance P.
   Lee, Annette
   Chinoy, Hector
   Lamb, Janine
TI International Immunochip Study in the Idiopathic Inflammatory Myopathies
   Identifies Novel Susceptibility Loci and Confirms HLA As Strongest
   Genetic Risk Factor.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Rothwell, Simon; Cobb, Joanna; Chinoy, Hector] Univ Manchester, Arthrit Res UK, Ctr Genet & Genom, Manchester, Lancs, England.
   [Cooper, Robert G.] Univ Liverpool, Liverpool L69 3BX, Merseyside, England.
   [Lundberg, Ingrid E.; Padyukov, Leonid] Karolinska Univ Hosp, Rheumatol Unit, Solna, Sweden.
   [Lundberg, Ingrid E.; Padyukov, Leonid] Karolinska Inst, Stockholm, Sweden.
   [Miller, Frederick W.; Rider, Lisa G.; O'Hanlon, Terrance P.] NIEHS, Environm Autoimmun Grp, NIH, Bethesda, MD USA.
   [Gregersen, Peter K.] Feinstein Inst Med Res, Manhasset, NY USA.
   [Vencovsky, Jiri] Charles Univ Prague, Inst Rheumatol, Prague, Czech Republic.
   [Vencovsky, Jiri] Charles Univ Prague, Dept Rheumatol, Fac Med 1, Prague, Czech Republic.
   [Danko, Katalin] Univ Debrecen, Debrecan, Hungary.
   [Wedderburn, Lucy R.] UCL, Arthritis Res UK Ctr Adolescent Rheumatol, London, England.
   [Limaye, Vidya] Royal Adelaide Hosp, Adelaide, SA 5000, Australia.
   [Selva O'Callaghan, Albert] Vall dHebron Gen Hosp, Barcelona, Spain.
   [Hanna, Michael G.; Machado, Pedro] UCL Inst Neurol, MRC, Ctr Neuromuscular Dis, London, England.
   [Pachman, Lauren M.] Ann & Robert H Lurie Childrens Hosp Chicago Res C, Chicago, IL USA.
   [Reed, Ann M.] Mayo Clin, Rochester, MN USA.
   [Platt, Hazel; Ollier, William E.; Lamb, Janine] Univ Manchester, Ctr Integrated Genom Med Res, Manchester, Lancs, England.
   [Molberg, Oyvind] Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Rheumatol, N-0027 Oslo, Norway.
   [Benveniste, Olivier] Hop La Pitie Salpetriere, APHP, Paris, France.
   [Mathiesen, Pernille] Holbaek Univ Hosp, Dept Paediat, Holbaek, Denmark.
   [Radstake, Timothy] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Doria, Andrea] Univ Padua, Padua, Italy.
   [De Bleecker, Jan; De Paepe, Boel] Univ Ghent, B-9000 Ghent, Belgium.
   [Maurer, Britta] Univ Zurich Hosp, Div Rheumatol, CH-8091 Zurich, Switzerland.
   [Lee, Annette] Feinstein Inst Med Rsch, Manhasset, NY USA.
RI De Paepe, Boel/B-7548-2013
OI De Paepe, Boel/0000-0001-9403-4401
NR 0
TC 0
Z9 0
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2953
BP S1290
EP S1291
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384906187
ER

PT J
AU Sahni, S
   Mangano, K
   Tucker, K
   Fox, C
   Kiel, DP
   Zhang, XC
   Hannan, MT
AF Sahni, Shivani
   Mangano, Kelsey
   Tucker, Katherine
   Fox, Caroline
   Kiel, Douglas P.
   Zhang, Xiaochun
   Hannan, Marian T.
TI No Association of Serum Uric Acid with Hip Fracture Risk in Older Men
   and Women from the Framingham Original Cohort.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Sahni, Shivani; Mangano, Kelsey; Kiel, Douglas P.; Hannan, Marian T.] Harvard Univ, Sch Med, Dept Med, Inst Aging Res,Beth Israel Deaconess Med Ctr,Hebr, Boston, MA USA.
   [Tucker, Katherine] Univ Massachusetts, Lowell, MA USA.
   [Fox, Caroline] NHLBI, Framingham Heart Study, Framingham, MA USA.
   [Fox, Caroline] NHLBI, Ctr Populat Studies, Framingham, MA USA.
   [Zhang, Xiaochun] Hebrew Senior Life, Inst Aging Res, Roslindale, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2047
BP S900
EP S900
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904197
ER

PT J
AU Taurog, JD
   Haimovich, Y
   Barnea, E
   Bassani-Sternberg, M
   Yair-Sabag, S
   Dorris, ML
   Satumtira, N
   Nguyen, M
   Hamner, RE
   Tran, TM
   Colbert, RA
   Admon, A
AF Taurog, Joel D.
   Haimovich, Yael
   Barnea, Eilon
   Bassani-Sternberg, Michal
   Yair-Sabag, Shira
   Dorris, Martha L.
   Satumtira, Nimman
   Mylinh Nguyen
   Hamner, Robert E.
   Tran, Tri M.
   Colbert, Robert A.
   Admon, Arie
TI The HLA-B27 Peptidome in Vivo in Transgenic Rats.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Taurog, Joel D.; Dorris, Martha L.; Satumtira, Nimman; Mylinh Nguyen; Hamner, Robert E.] UT Southwestern Med Ctr, Dallas, TX USA.
   [Haimovich, Yael; Barnea, Eilon; Bassani-Sternberg, Michal; Yair-Sabag, Shira; Admon, Arie] Technion Israel Inst Technol, Haifa, Israel.
   [Tran, Tri M.; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 607
BP S266
EP S267
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901151
ER

PT J
AU Teos, LY
   Swaim, B
   Grisius, M
   Cotrim, AP
   Jang, SI
   Bebris, L
   Yule, D
   Illei, GG
   Ambudkar, I
   Alevizos, I
AF Teos, Leyla Y.
   Swaim, Bill
   Grisius, Margaret
   Cotrim, Ana Paola
   Jang, Shyh-Ing
   Bebris, Lolita
   Yule, David
   Illei, Gabor G.
   Ambudkar, Indu
   Alevizos, Ilias
TI IP3R3 Deficit Underlies the Loss of Fluid Secretion in Salivary Glands
   from Sjogren's Syndrome Patients.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Teos, Leyla Y.; Grisius, Margaret; Cotrim, Ana Paola; Bebris, Lolita; Ambudkar, Indu] NIH, Bethesda, MD 20892 USA.
   [Swaim, Bill; Illei, Gabor G.] NIDCR, NIH, Bethesda, MD USA.
   [Jang, Shyh-Ing] NIDCR, Bethesda, MD USA.
   [Yule, David] Univ Rochester, Rochester, NY USA.
   [Alevizos, Ilias] NIDCR, NIH 10 1N110, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 529
BP S230
EP S230
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901074
ER

PT J
AU ter Haar, N
   Jeyaratnam, J
   Anton, J
   Galeotti, C
   Barron, K
   Brogan, P
   Cantarini, L
   Gattorno, M
   Grateau, G
   Hentgen, V
   Hofer, M
   Kallinich, T
   Kone-Paut, I
   Kuemmerle-Deschner, J
   Lachmann, H
   Ozdogan, H
   Ozen, S
   Russo, R
   Uziel, Y
   Wouters, C
   Feldman, B
   Vastert, B
   Wulffraat, N
   Simon, A
   Frenkel, J
AF ter Haar, Nienke
   Jeyaratnam, Jerold
   Anton, Jordi
   Galeotti, Caroline
   Barron, Karyl
   Brogan, Paul
   Cantarini, Luca
   Gattorno, Marco
   Grateau, Gilles
   Hentgen, Veronique
   Hofer, Michael
   Kallinich, Tilmann
   Kone-Paut, Isabelle
   Kuemmerle-Deschner, Jasmin
   Lachmann, Helen
   Ozdogan, Huri
   Ozen, Seza
   Russo, Ricardo
   Uziel, Yosef
   Wouters, Carine
   Feldman, Brian
   Vastert, Bas
   Wulffraat, Nico
   Simon, Anna
   Frenkel, Joost
TI Evidence Based Recommendatinos for Diagnosis and Management of
   Mevalonate Kinase Deficiency (MKD)
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [ter Haar, Nienke; Jeyaratnam, Jerold; Vastert, Bas; Frenkel, Joost] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Anton, Jordi] Univ Barcelona, Hosp St Joan de Deu, Pediat Rheumatol Unit, Barcelona, Spain.
   [Galeotti, Caroline; Kone-Paut, Isabelle] Univ Paris 11, Bicetre Hosp, Paris, France.
   [Barron, Karyl] NIH, Bethesda, MD 20892 USA.
   [Brogan, Paul] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Cantarini, Luca] Univ Siena, I-53100 Siena, Italy.
   [Gattorno, Marco] Ist Giannina Gaslini, I-16148 Genoa, Italy.
   [Grateau, Gilles] Hop Tenon, F-75970 Paris, France.
   [Hentgen, Veronique] Versailles Hosp, Le Chesnay, France.
   [Hofer, Michael] Ctr Multisite Romand Rhumatol Pediat, Lausanne, Switzerland.
   [Kallinich, Tilmann] Univ Med Berlin, Charite, Berlin, Germany.
   [Kuemmerle-Deschner, Jasmin] Univ Hosp Tuebingen, Tubingen, Germany.
   [Lachmann, Helen] UCL, Sch Med, London W1N 8AA, England.
   [Ozdogan, Huri] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Ozen, Seza] Hacettepe Univ, Dept Pediat Rheumatol, Ankara, Turkey.
   [Russo, Ricardo] Hosp Pediat, Buenos Aires, DF, Argentina.
   [Uziel, Yosef] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Wouters, Carine] Univ Leuven, Lab Pediat Immunol, Univ Hosp Leuven, Leuven, Belgium.
   [Feldman, Brian] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Wulffraat, Nico] UMC Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [Simon, Anna] Radboudumc, Nijmegen, Netherlands.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2282
BP S995
EP S995
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904427
ER

PT J
AU ter Haar, N
   Brogan, P
   Grateau, G
   Anton, J
   Barron, K
   Cantarini, L
   Frenkel, J
   Galeotti, C
   Hentgen, V
   Hofer, M
   Kallinich, T
   Kone-Paut, I
   Kuemmerle-Deschner, J
   Ozdogan, H
   Ozen, S
   Russo, R
   Simon, A
   Uziel, Y
   Wouters, C
   Feldman, B
   Vastert, B
   Wulffraat, N
   Lachmann, H
   Gattorno, M
AF ter Haar, Nienke
   Brogan, Paul
   Grateau, Gilles
   Anton, Jordi
   Barron, Karyl
   Cantarini, Luca
   Frenkel, Joost
   Galeotti, Caroline
   Hentgen, Veronique
   Hofer, Michael
   Kallinich, Tilmann
   Kone-Paut, Isabelle
   Kuemmerle-Deschner, Jasmin
   Ozdogan, Huri
   Ozen, Seza
   Russo, Ricardo
   Simon, Anna
   Uziel, Yosef
   Wouters, Carine
   Feldman, Brian
   Vastert, Bas
   Wulffraat, Nico
   Lachmann, Helen
   Gattorno, Marco
TI Evidence Based Recommendations for Diagnosis and Management of Tumor
   Necrosis Factor Receptor-1 Associated Periodic Syndrome (TRAPS)
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [ter Haar, Nienke; Frenkel, Joost; Vastert, Bas] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Brogan, Paul] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Grateau, Gilles] Hop Tenon, F-75970 Paris, France.
   [Anton, Jordi] Univ Barcelona, Hosp St Joan de Deu, Pediat Rheumatol Unit, Barcelona, Spain.
   [Barron, Karyl] NIH, Bethesda, MD 20892 USA.
   [Cantarini, Luca] Univ Siena, I-53100 Siena, Italy.
   [Galeotti, Caroline] Univ Paris 11, Bicetre Hosp, Paris, France.
   [Hentgen, Veronique] Versailles Hosp, Le Chesnay, France.
   [Hofer, Michael] Ctr Multisite Romand Rhumatol Pediat, Lausanne, Switzerland.
   [Kallinich, Tilmann] Univ Med Berlin, Charite, Berlin, Germany.
   [Kuemmerle-Deschner, Jasmin] Univ Hosp Tuebingen, Tubingen, Germany.
   [Ozdogan, Huri] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Ozen, Seza] Hacettepe Univ, Dept Pediat Rheumatol, Ankara, Turkey.
   [Russo, Ricardo] Hosp Pediat, Buenos Aires, DF, Argentina.
   [Simon, Anna] Radboudumc, Nijmegen, Netherlands.
   [Uziel, Yosef] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Wouters, Carine] Univ Leuven, Lab Pediat Immunol, Univ Hosp Leuven, Leuven, Belgium.
   [Feldman, Brian] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Wulffraat, Nico] UMC Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [Lachmann, Helen] UCL, Sch Med, London W1N 8AA, England.
   [Gattorno, Marco] Ist Giannina Gaslini, I-16148 Genoa, Italy.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2279
BP S993
EP S993
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904424
ER

PT J
AU ter Haar, N
   Oswald, M
   Cantarini, L
   Gattorno, M
   Hofer, M
   Kone-Paut, I
   Lopez, JA
   Barron, K
   Brogan, P
   Frenkel, J
   Galeotti, C
   Grateau, G
   Hentgen, V
   Kallinich, T
   Lachmann, H
   Ozdogan, H
   Ozen, S
   Russo, R
   Simon, A
   Uziel, Y
   Wouters, C
   Feldman, B
   Vastert, B
   Wulffraat, N
   Benseler, S
   Kuemmerle-Deschner, J
AF ter Haar, Nienke
   Oswald, Marlen
   Cantarini, Luca
   Gattorno, Marco
   Hofer, Michael
   Kone-Paut, Isabelle
   Anton Lopez, Jordi
   Barron, Karyl
   Brogan, Paul
   Frenkel, Joost
   Galeotti, Caroline
   Grateau, Gilles
   Hentgen, Veronique
   Kallinich, Tilmann
   Lachmann, Helen
   Ozdogan, Huri
   Ozen, Seza
   Russo, Ricardo
   Simon, Anna
   Uziel, Yosef
   Wouters, Carine
   Feldman, Brian
   Vastert, Bas
   Wulffraat, Nico
   Benseler, Susanne
   Kuemmerle-Deschner, Jasmin
TI Evidence Based Recommendations for the Management of Cryopyrin
   Associated Periodic Syndromes (CAPS)
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [ter Haar, Nienke; Frenkel, Joost; Vastert, Bas; Wulffraat, Nico] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Oswald, Marlen; Kuemmerle-Deschner, Jasmin] Univ Hosp Tuebingen, Tubingen, Germany.
   [Cantarini, Luca] Univ Siena, I-53100 Siena, Italy.
   [Gattorno, Marco] Inst Giannina Gaslini, Genoa, Italy.
   [Hofer, Michael] Ctr Multisite Romand Rhumatol Pediat, Lausanne, Switzerland.
   [Kone-Paut, Isabelle; Galeotti, Caroline] Univ Paris 11, Bicetre Hosp, Paris, France.
   [Anton Lopez, Jordi] Univ Childrenxs Hosp, Barcelona, Spain.
   [Barron, Karyl] NIH, Bethesda, MD 20892 USA.
   [Brogan, Paul] Great Ormond St Hosp Sick Children, London WC1N 3JH, England.
   [Grateau, Gilles] Hop Tenon, F-75970 Paris, France.
   [Hentgen, Veronique] Versailles Hosp, Le Chesnay, France.
   [Kallinich, Tilmann] Univ Med Berlin, Charite, Berlin, Germany.
   [Lachmann, Helen] UCL, Sch Med, London W1N 8AA, England.
   [Ozdogan, Huri] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
   [Ozen, Seza] Hacettepe Univ, Ankara, Turkey.
   [Russo, Ricardo] Hosp Pediat, Buenos Aires, DF, Argentina.
   [Simon, Anna] Radboudumc, Nijmegen, Netherlands.
   [Uziel, Yosef] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Wouters, Carine] Univ Leuven, Lab Pediat Immunol, Univ Hosp Leuven, Leuven, Belgium.
   [Feldman, Brian; Benseler, Susanne] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 2280
BP S993
EP S994
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904425
ER

PT J
AU Tran, TM
   Hong, SH
   Edwan, JH
   Colbert, RA
AF Tran, Tri M.
   Hong, Sohee
   Edwan, Jehad H.
   Colbert, Robert A.
TI Effect of ERAP1 Knockdown on Conformation of HLA-B27 and Other HLA Class
   I Molecules in Human Monocytic Cells.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Tran, Tri M.; Hong, Sohee; Edwan, Jehad H.; Colbert, Robert A.] NIAMS, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 619
BP S272
EP S272
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901163
ER

PT J
AU Unizony, S
   Miloslavsky, EM
   Villarreal, M
   Merkel, PA
   Monach, P
   St Claire, EW
   Kallenberg, C
   Ikle, D
   Spiera, RF
   Tchao, N
   Phippard, DJ
   Ding, L
   Langford, CA
   Seo, P
   Hoffman, GS
   Stone, JH
   Specks, U
AF Unizony, Sebastian
   Miloslavsky, Eli M.
   Villarreal, Miguel
   Merkel, Peter A.
   Monach, Paul
   St Claire, E. William
   Kallenberg, Cees
   Ikle, David
   Spiera, Robert F.
   Tchao, Nadia
   Phippard, Deborah J.
   Ding, Linna
   Langford, Carol A.
   Seo, Philip
   Hoffman, Gary S.
   Stone, John H.
   Specks, Ulrich
TI Comparison of Clinicopathologically- and Serologically-Based
   Classification Systems for ANCA-Associated Vasculitis
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Unizony, Sebastian; Miloslavsky, Eli M.; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Villarreal, Miguel; Ikle, David] Rho, Chapel Hill, NC USA.
   [Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA.
   [Monach, Paul] Boston Univ, Boston, MA 02215 USA.
   [St Claire, E. William] Duke Univ Sch Med, Durham, NC USA.
   [Kallenberg, Cees] Univ Groningen, Groningen, Netherlands.
   [Spiera, Robert F.] Hosp Special Surg, New York, NY 10021 USA.
   [Tchao, Nadia; Phippard, Deborah J.] Immune Tolerance Network, Bethesda, MD USA.
   [Ding, Linna] NIAID, Bethesda, MD 20892 USA.
   [Langford, Carol A.] Cleveland Clin, Ctr Vasculitis Care & Res, Cleveland, OH 44106 USA.
   [Seo, Philip] Johns Hopkins Univ, Johns Hopkins Vasculitis Ctr, Baltimore, MD USA.
   [Hoffman, Gary S.] Cleveland Clin Fdn, Ctr Vasculitis Care & Res, Cleveland, OH 44195 USA.
   [Specks, Ulrich] Mayo Clin, Rochester, MN USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1766
BP S775
EP S776
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384903389
ER

PT J
AU Nguyen, V
   Tegla, C
   Cudrici, C
   Badea, T
   Rus, H
   Rus, V
AF Vinh Nguyen
   Tegla, Cosmin
   Cudrici, Cornelia
   Badea, Tudor
   Rus, Horea
   Rus, Violeta
TI Lack of Response Gene to Complement-32 Impairs Th17 Differentiation and
   Attenuates Lupus-like Chronic Graft Versus Host Disease.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Vinh Nguyen; Tegla, Cosmin; Cudrici, Cornelia; Rus, Horea; Rus, Violeta] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Vinh Nguyen; Tegla, Cosmin; Rus, Horea; Rus, Violeta] Vet Affairs Med Ctr, Baltimore, MD USA.
   [Badea, Tudor] NEI, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 639
BP S280
EP S280
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384901183
ER

PT J
AU Walitt, B
   Nahin, R
   Katz, RS
   Bergman, MJ
   Wolfe, F
AF Walitt, Brian
   Nahin, Richard
   Katz, Robert S.
   Bergman, Martin J.
   Wolfe, Frederick
TI Most Patients Diagnosed with Fibromyalgia By Physicians Do Not Have
   Fibromyalgia: The 2012 National Health Interview Survey Fibromyalgia
   Study.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Walitt, Brian] MedStar Hlth, Washington, DC USA.
   [Nahin, Richard] NIH, Bethedsa, MD USA.
   [Katz, Robert S.] Rush Med Coll, Chicago, IL 60612 USA.
   [Bergman, Martin J.] Taylor Hosp, Ridley Pk, PA USA.
   [Wolfe, Frederick] Natl Data Bank Rheumat Dis, Wichita, KS USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1106
BP S486
EP S487
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902211
ER

PT J
AU Walitt, B
   Nahin, R
   Katz, RS
   Bergman, MJ
   Wolfe, F
AF Walitt, Brian
   Nahin, Richard
   Katz, Robert S.
   Bergman, Martin J.
   Wolfe, Frederick
TI Development of Fibromyalgia and Polysymptomatic Distress Definitions in
   the National Health Interview Survey.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Walitt, Brian] MedStar Hlth, Washington, DC USA.
   [Nahin, Richard] NIH, Bethedsa, MD USA.
   [Katz, Robert S.] Rush Med Coll, Chicago, IL 60612 USA.
   [Bergman, Martin J.] Taylor Hosp, Ridley Pk, PA USA.
   [Wolfe, Frederick] Natl Data Bank Rheumat Dis, Wichita, KS USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 896
BP S396
EP S397
PG 2
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902003
ER

PT J
AU Wessel, A
   Vonortas, S
   Zilberman-Rudenko, J
   Siegel, R
   Hanson, E
AF Wessel, Alex
   Vonortas, Spiros
   Zilberman-Rudenko, Jevgenia
   Siegel, Richard
   Hanson, Eric
TI Behcets Disease in Females Due to Mutation in NEMO, the NF-Kb Essential
   Modulator.
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Wessel, Alex] NIH, Bethseda, MD USA.
   [Vonortas, Spiros; Siegel, Richard] NIAMS, NIH, Bethesda, MD USA.
   [Zilberman-Rudenko, Jevgenia] NIAMSD, NIH, Bethesda, MD 20892 USA.
   [Hanson, Eric] NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1212
BP S532
EP S532
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384902317
ER

PT J
AU Wu, XN
   Ye, YX
   Niu, JW
   Li, Y
   Li, X
   You, X
   Chen, H
   Zhao, LD
   Zeng, XF
   Zhang, FC
   Tang, FL
   He, W
   Cao, XT
   Zhang, X
   Lipsky, PE
AF Wu, Xiangni
   Ye, Yanxia
   Niu, Jingwen
   Li, Yang
   Li, Xin
   You, Xin
   Chen, Hua
   Zhao, Lidan
   Zeng, Xiaofeng
   Zhang, Fengchun
   Tang, Fulin
   He, Wei
   Cao, Xuetao
   Zhang, Xuan
   Lipsky, Peter E.
TI Defective PTEN Regulation and Function Contributes to B Cell
   HyperResponsiveness in Systemic Lupus Erythematosus
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Wu, Xiangni; Ye, Yanxia; Niu, Jingwen; Li, Yang; Li, Xin; You, Xin; Chen, Hua; Zhao, Lidan; Zeng, Xiaofeng; Zhang, Fengchun; Tang, Fulin; He, Wei; Zhang, Xuan] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China.
   [Wu, Xiangni; Ye, Yanxia; Niu, Jingwen; Li, Yang; Li, Xin; You, Xin; Chen, Hua; Zhao, Lidan; Zeng, Xiaofeng; Zhang, Fengchun; Tang, Fulin; He, Wei; Zhang, Xuan] Peking Union Med Coll, Beijing 100021, Peoples R China.
   [Cao, Xuetao] Peking Union Med Coll, Sch Basic Med, Beijing 100021, Peoples R China.
   [Cao, Xuetao] Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China.
   [Lipsky, Peter E.] NIH, Charlottesville, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2014
VL 66
SU 10
SI SI
MA 1949
BP S858
EP S858
PG 1
WC Rheumatology
SC Rheumatology
GA AS6PK
UT WOS:000344384904099
ER

PT J
AU Xiao, HG
   Bryksa, BC
   Bhaumik, P
   Gustchina, A
   Kiso, Y
   Yao, SQ
   Wlodawer, A
   Yada, RY
AF Xiao, Huogen
   Bryksa, Brian C.
   Bhaumik, Prasenjit
   Gustchina, Alla
   Kiso, Yoshiaki
   Yao, Shao Q.
   Wlodawer, Alexander
   Yada, Rickey Y.
TI The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically
   active
SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY
LA English
DT Article
DE Plasmepsin; Zymogen; Refolding; Prosegment; Protease inhibitor;
   Plasmodium falciparum
ID MALARIAL ASPARTIC PROTEASE; BETA-SECRETASE; DENATURED SUBTILISIN;
   KINETIC STABILITY; HOST ERYTHROCYTE; NATIVE-STATE; PRO-SEQUENCE;
   PROTEINS; INHIBITION; ARGININE
AB Plasmepsin V, a membrane-bound aspartic protease present in Plasmodium falciparum, is involved in the export of malaria parasite effector proteins into host erythrocytes and therefore is a potential target for antimalarial drug development. The present study reports the bacterial recombinant expression and initial characterization of zymogenic and mature plasmepsin V. A 484-residue truncated form of proplasmepsin (Glu37-Asn521) was fused to a fragment of thioredoxin and expressed as inclusion bodies. Refolding conditions were optimized and zymogen was processed into a mature form via cleavage at the Asn80-AIa81 peptide bond. Mature plasmepsin V exhibited a pH optimum of 5.5-7.0 with K-m and k(cat) of 4.6 mu M and 0.24 s(-1), respectively, at pH 6.0 using the substrate DABCYL-LNKRLLHETQ-E(EDANS). Furthermore, the prosegment of proplasmepsin V was shown to be nonessential for refolding and inhibition. Unexpectedly, unprocessed proplasmepsin V was enzymatically active with slightly reduced substrate affinity (similar to 2-fold), and similar pH optimum as well as turnover compared to the mature form. Both zymogenic and mature plasmepsin V were partially inhibited by pepstatin A as well as several KNI aspartic protease inhibitors while certain metals strongly inhibited activity. Overall, the present study provides the first report on the nonessentiality of the prosegment for plasmepsin V folding and activity, and therefore, subsequent characterization of its structure-function relationships of both zymogen and mature forms in the development of novel inhibitors with potential antimalarial activities is warranted. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Xiao, Huogen; Bryksa, Brian C.; Yada, Rickey Y.] Univ Guelph, Dept Food Sci, Guelph, ON N1G 2W1, Canada.
   [Bhaumik, Prasenjit] Indian Inst Technol, Dept Biosci & Bioengn, Bombay 400076, Maharashtra, India.
   [Gustchina, Alla; Wlodawer, Alexander] NCI, Macromol Crystallog Lab, Prot Struct Sect, Frederick, MD 21702 USA.
   [Kiso, Yoshiaki] Nagahama Inst Biosci & Technol, Lab Peptide Sci, Nagahama, Shiga 5260829, Japan.
   [Yao, Shao Q.] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore.
   [Yada, Rickey Y.] Univ British Columbia, Fac Land & Food Syst, Vancouver, BC V6T 1Z4, Canada.
RP Yada, RY (reprint author), Univ Guelph, Dept Food Sci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada.
EM r.yada@ubc.ca
RI Bryksa, Brian/A-8281-2013
OI Bryksa, Brian/0000-0001-5626-8012
FU Natural Sciences and Engineering Research Council of Canada; Canada
   Research Chairs program; Intramural Research Program of the National
   Institutes of Health
FX This research was supported by the Natural Sciences and Engineering
   Research Council of Canada, the Canada Research Chairs program, and the
   Intramural Research Program of the National Institutes of Health.
NR 53
TC 9
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-6851
EI 1872-9428
J9 MOL BIOCHEM PARASIT
JI Mol. Biochem. Parasitol.
PD OCT
PY 2014
VL 197
IS 1-2
BP 56
EP 63
DI 10.1016/j.molbiopara.2014.10.004
PG 8
WC Biochemistry & Molecular Biology; Parasitology
SC Biochemistry & Molecular Biology; Parasitology
GA AX7ZB
UT WOS:000347129000010
PM 25447707
ER

PT J
AU Kim, HY
   Huang, BX
   Spector, AA
AF Kim, Hee-Yong
   Huang, Bill X.
   Spector, Arthur A.
TI Phosphatidylserine in the brain: Metabolism and function
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
DE Docosahexaenoic acid; Serine; Signal transduction; Membranes; Neuron;
   Cognition
ID PROTEIN-KINASE-C; ARACHIDONOYL L-SERINE; PUTATIVE AMINOPHOSPHOLIPID
   TRANSLOCASE; MILD COGNITIVE IMPAIRMENT; MEDIATED MEMBRANE-FUSION;
   FATTY-ACID DEFICIENCY; HAMSTER OVARY CELLS; RAT-BRAIN; DOCOSAHEXAENOIC
   ACID; MAMMALIAN-CELLS
AB Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the inner leaflet of the plasma membrane in neural tissues. PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum. Activation of Akt, Raf-1 and protein kinase C signaling, which supports neuronal survival and differentiation, requires interaction of these proteins with PS localized in the cytoplasmic leaflet of the plasma membrane. Furthermore, neurotransmitter release by exocytosis and a number of synaptic receptors and proteins are modulated by PS present in the neuronal membranes. Brain is highly enriched with docosahexaenoic acid (DHA), and brain PS has a high DHA content. By promoting PS synthesis, DHA can uniquely expand the PS pool in neuronal membranes and thereby influence PS-dependent signaling and protein function. Ethanol decreases DHA-promoted PS synthesis and accumulation in neurons, which may contribute to the deleterious effects of ethanol intake. Improvement of some memory functions has been observed in cognitively impaired subjects as a result of PS supplementation, but the mechanism is unclear. Published by Elsevier Ltd.
C1 [Kim, Hee-Yong; Huang, Bill X.; Spector, Arthur A.] NIAAA, Lab Mol Signaling, NIH, Bethesda, MD 20892 USA.
RP Kim, HY (reprint author), NIAAA, Lab Mol Signaling, NIH, 5625 Fishers Lane,Rm 3 N-07, Bethesda, MD 20892 USA.
EM hykim@nih.gov
FU Intramural NIH HHS [ZIA AA000284-23]
NR 200
TC 12
Z9 12
U1 5
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD OCT
PY 2014
VL 56
BP 1
EP 18
DI 10.1016/j.plipres.2014.06.002
PG 18
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AX7ZD
UT WOS:000347129200001
PM 24992464
ER

PT J
AU Zhang, Y
   Tian, SH
   Liu, ZQ
   Zhang, JY
   Zhang, ML
   Bosenberg, MW
   Kedl, RM
   Waldmann, TA
   Storkus, WJ
   Falo, LD
   You, ZY
AF Zhang, Yi
   Tian, Shenghe
   Liu, Zuqiang
   Zhang, Jiying
   Zhang, Meili
   Bosenberg, Marcus W.
   Kedl, Ross M.
   Waldmann, Thomas A.
   Storkus, Walter J.
   Falo, Louis D., Jr.
   You, Zhaoyang
TI Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer
   vaccine potency
SO ONCOIMMUNOLOGY
LA English
DT Article
DE cancer vaccines; DC; IL-15
ID CD8(+) T-CELLS; ESTABLISHED TUMORS; ANTITUMOR IMMUNITY;
   TRANS-PRESENTATION; IN-VIVO; MEMORY PHENOTYPE; MURINE MODELS; DNA
   VACCINE; IL-15; INDUCTION
AB IL-15 supports improved antitumor immunity. How to best incorporate IL-15 into vaccine formulations for superior cancer immunotherapy remains a challenge. DC-derived IL-15 (DCIL-15) notably has the capacity to activate DC, to substitute for CD4(+) Th and to potentiate vaccine efficacy making IL-15-based therapies attractive treatment options. We observed in transplantable melanoma, glioma and metastatic breast carcinoma models that DCIL-15-based DNA vaccines in which DC specifically express IL-15 and simultaneously produce tumor Aghsp70 were able to mediate potent therapeutic efficacy that required both host Batf3(+) DC and CD8(+) T cells. In an inducible Braf(V600E)/Pten-driven murine melanoma model, DCIL-15 (not rIL-15)-based DNA vaccines elicited durable therapeutic CD8(+) T cell-dependent antitumor immunity. DCIL-15 was found to be superior to rIL-15 in "licensing" both mouse and human DC, and for activating CD8(+) T cells. Such activation occurred even in the presence of Treg, without a need for CD4(+) Th, but was IL15/ IL-15R alpha-dependent. A single low-dose of DCIL-15 (not rIL-15)-based DC vaccines induced therapeutic antitumor immunity. CD14(+) DC emigrating from human skin explants genetically-immunized by IL-15 and Aghsp70 were more effective than similar DC emigrating from the explants genetically-immunized by Aghsp70 in the presence of rIL-15 in expressing membrane-bound IL-15/ IL-15R alpha and activating CD8(+) T cells. These results support future clinical use of DCIL-15 as a therapeutic agent in battling cancer.
C1 [Zhang, Yi; Tian, Shenghe; Liu, Zuqiang; Zhang, Jiying; Storkus, Walter J.; Falo, Louis D., Jr.; You, Zhaoyang] Univ Pittsburgh, Sch Med, Dept Dermatol, Pittsburgh, PA 15261 USA.
   [Zhang, Meili; Waldmann, Thomas A.] NCI, Lymphoid Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Bosenberg, Marcus W.] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06510 USA.
   [Bosenberg, Marcus W.] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA.
   [Kedl, Ross M.] Univ Colorado, Dept Immunol & Microbiol, Aurora, CO USA.
   [Storkus, Walter J.; Falo, Louis D., Jr.; You, Zhaoyang] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA.
   [Storkus, Walter J.; Falo, Louis D., Jr.; You, Zhaoyang] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
RP You, ZY (reprint author), Univ Pittsburgh, Sch Med, Dept Dermatol, Pittsburgh, PA 15261 USA.
EM youz@upmc.edu
FU Department of Dermatology at The University of Pittsburgh; NIH
   [R01CA108813, R01CA108813-04S2, P50CA121973, R01AI076060, R01EB01277]
FX This work was supported by Department of Dermatology at The University
   of Pittsburgh (ZY) and NIH grants R01CA108813 and R01CA108813-04S2 (ZY),
   P50CA121973, R01AI076060 and R01EB01277 (LDF).
NR 57
TC 7
Z9 9
U1 1
U2 9
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 2162-4011
EI 2162-402X
J9 ONCOIMMUNOLOGY
JI OncoImmunology
PD OCT
PY 2014
VL 3
IS 10
AR e959321
DI 10.4161/21624011.2014.959321
PG 12
WC Oncology; Immunology
SC Oncology; Immunology
GA AX4SY
UT WOS:000346922700013
ER

PT J
AU Famakin, BM
AF Famakin, Bolanle M.
TI The Immune Response to Acute Focal Cerebral Ischemia and Associated
   Post-stroke Immunodepression: A Focused Review
SO AGING AND DISEASE
LA English
DT Review
DE focal cerebral ischemia; cerebral ischemia; immune response; innate
   immunity; adaptive immunity; stroke-induced immunodepression
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERCELLULAR-ADHESION MOLECULE-1;
   TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS;
   TISSUE-PLASMINOGEN-ACTIVATOR; AMERICAN-HEART-ASSOCIATION; PREVENTIVE
   ANTIBACTERIAL THERAPY; MESSENGER-RNA EXPRESSION; BRAIN-INJURY; ARTERY
   OCCLUSION
AB It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial immune activation is rapid, occurs via the innate immune response and leads to inflammation. The inflammatory mediators produced during the innate immune response in turn lead to recruitment of inflammatory cells and the production of more inflammatory mediators that result in activation of the adaptive immune response. Under ideal conditions, this inflammation gives way to tissue repair and attempts at regeneration. However, for reasons that are just being understood, immunosuppression occurs following acute stroke leading to post-stroke immunodepression. This review focuses on the current state of knowledge regarding innate and adaptive immune activation in response to focal cerebral ischemia as well as the immunodepression that can occur following stroke. A better understanding of the intricate and complex events that take place following immune response activation, to acute cerebral ischemia, is imperative for the development of effective novel immunomodulatory therapies for the treatment of acute stroke. Aging and and and and and and and Disease
C1 [Famakin, Bolanle M.] NINDS, NIH, Stroke Branch, Bethesda, MD 20892 USA.
RP Famakin, BM (reprint author), Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA.
EM BFamakin@som.umaryland.edu
FU intramural research program of the National Institutes of Health,
   National Institute of Neurological Disorders and Stroke
FX This work was supported by the intramural research program of the
   National Institutes of Health, National Institute of Neurological
   Disorders and Stroke. The author would like to acknowledge Dr. John
   Hallenbeck for critical review of the contents of the manuscript.
NR 211
TC 24
Z9 31
U1 2
U2 9
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD OCT
PY 2014
VL 5
IS 5
BP 307
EP 326
PG 20
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA AW5BL
UT WOS:000346290900003
PM 25276490
ER

PT J
AU Fu, HQ
   Lin, CM
   Zhang, Y
   Utani, K
   Smith, O
   Ryan, M
   Kim, R
   Aladjem, MI
AF Fu, Haiqing
   Lin, Chii Mei
   Zhang, Ya
   Utani, Koichi
   Smith, Owen
   Ryan, Michael
   Kim, RyanGuk
   Aladjem, Mirit I.
TI Epigenetic regulation of DNA replication in mammalian cells
SO BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
LA English
DT Meeting Abstract
C1 [Fu, Haiqing; Lin, Chii Mei; Zhang, Ya; Utani, Koichi; Smith, Owen; Aladjem, Mirit I.] NCI, Dev Therapeut Branch, Bethesda, MD 20892 USA.
   [Ryan, Michael; Kim, RyanGuk] InSilico Inc, Fairfax, VA 22033 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0829-8211
EI 1208-6002
J9 BIOCHEM CELL BIOL
JI Biochem. Cell Biol.
PD OCT
PY 2014
VL 92
IS 5
BP 335
EP 335
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AW6FU
UT WOS:000346366000015
ER

PT J
AU Yuan, TL
   Fellmann, C
   Lee, CS
   Ritchie, CD
   Thapar, V
   Lee, LG
   Hsu, DJ
   Grace, D
   Carver, JO
   Zuber, J
   Luo, J
   McCormick, F
   Lowe, SW
AF Yuan, Tina L.
   Fellmann, Christof
   Lee, Chih-Shia
   Ritchie, Cayde D.
   Thapar, Vishal
   Lee, Liam G.
   Hsu, Dennis J.
   Grace, Danielle
   Carver, Joseph O.
   Zuber, Johannes
   Luo, Ji
   McCormick, Frank
   Lowe, Scott W.
TI Development of siRNA Payloads to Target KRAS-Mutant Cancer
SO CANCER DISCOVERY
LA English
DT Article
ID ORAL MEK INHIBITOR; CELL LUNG-CANCER; PHASE-II; MAPK PATHWAY; C-RAF;
   RNAI; SURVIVAL; NANOPARTICLES; P110-ALPHA; ACTIVATE
AB RNAi is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA payloads with reliable in vivo delivery for efficient target inhibition. We used a functional "Sensor" assay to establish a library of potent siRNAs against RAS pathway genes and to show that they efficiently suppress their targets at low dose. This reduces off-target effects and enables combination gene knockdown. We administered Sensor siRNAs in vitro and in vivo and validated the delivery of KRAS siRNA alone and siRNA targeting the complete RAF effector node (A/B/CRAF) as promising strategies to treat KRAS-mutant colorectal cancer. We further demonstrate that improved therapeutic efficacy is achieved by formulating siRNA payloads that combine both single-gene siRNA and node-targeted siRNAs (KRAS + PIK3CA/B). The customizable nature of Sensor siRNA payloads offers a universal platform for the combination target identification and development of RNAi therapeutics.
   SIGNIFICANCE: To advance RNAi therapy for KRAS-mutant cancer, we developed a validated siRNA library against RAS pathway genes that enables combination gene silencing. Using an in vivo model for real-time siRNA delivery tracking, we show that siRNA-mediated inhibition of KRAS as well as RAF or PI3K combinations can impair KRAS-mutant colorectal cancer in xenograft models. (C) 2014 AACR.
C1 [Yuan, Tina L.; Ritchie, Cayde D.; McCormick, Frank] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA.
   [Fellmann, Christof; Thapar, Vishal; Grace, Danielle; Zuber, Johannes; Lowe, Scott W.] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
   [Lee, Chih-Shia; Lee, Liam G.; Hsu, Dennis J.; Carver, Joseph O.; Luo, Ji] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Thapar, Vishal; Grace, Danielle; Lowe, Scott W.] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA.
   [Zuber, Johannes] Res Inst Mol Pathol, A-1030 Vienna, Austria.
   [Lowe, Scott W.] Howard Hughes Med Inst, New York, NY USA.
RP Lowe, SW (reprint author), Mem Sloan Kettering Canc Ctr, 415 East 68th St,Z-1114, New York, NY 10065 USA.
EM ji.luo@nih.gov; mccormic@cc.ucsf.edu; lowes@mskcc.org
OI Fellmann, Christof/0000-0002-9545-5723
FU Susan G. Komen Foundation [KG111338]; Daiichi Sankyo; NCI Intramural
   Research Program [1ZIABC011437]; Lustgarten Foundation; Howard Hughes
   Medical Institute
FX This work was supported by funding from the Susan G. Komen Foundation
   (KG111338 to T.L. Yuan), Daiichi Sankyo (to T.L. Yuan and F. McCormick),
   the NCI Intramural Research Program (1ZIABC011437 to J. Luo), the
   Lustgarten Foundation, and the Howard Hughes Medical Institute (to S. W.
   Lowe).
NR 38
TC 19
Z9 20
U1 3
U2 7
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 2159-8274
EI 2159-8290
J9 CANCER DISCOV
JI Cancer Discov.
PD OCT
PY 2014
VL 4
IS 10
BP 1182
EP 1197
DI 10.1158/2159-8290.CD-13-0900
PG 16
WC Oncology
SC Oncology
GA AW8GP
UT WOS:000346499800026
PM 25100204
ER

PT J
AU McGlynn, KA
   Divine, GW
   Sahasrabuddhe, VV
   Engel, LS
   VanSlooten, A
   Wells, K
   Yood, MU
   Alford, SH
AF McGlynn, Katherine A.
   Divine, George W.
   Sahasrabuddhe, Vikrant V.
   Engel, Lawrence S.
   VanSlooten, Ashley
   Wells, Karen
   Yood, Marianne Ulcickas
   Alford, Sharon Hensley
TI Statin use and risk of hepatocellular carcinoma in a US population
SO CANCER EPIDEMIOLOGY
LA English
DT Article
DE Statins; Liver cancer; Epidemiology
ID CORONARY-HEART-DISEASE; C VIRUS-INFECTION; CANCER-RISK; PRAVASTATIN USE;
   LIVER; METAANALYSIS; SAFETY; CHOLESTEROL; PREVENTION; EFFICACY
AB Purpose: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are medications widely prescribed to reduce cholesterol levels. Observational studies in high-risk populations, mostly in Asia, have suggested that statins are associated with a reduced risk of hepatocellular carcinoma (HCC). The current study sought to evaluate the association of statin use and HCC in a U.S.-based, low-risk, general population.
   Methods: A nested case-control study was conducted among members of the Health Alliance Plan HMO of the Henry Ford Health System enrolled between 1999 and 2010. Electronic pharmacy records of statin use were compared among tumor registry-confirmed cases of HCC (n = 94) and controls (n = 468) matched on age, sex, diagnosis date, and length of HMO enrolment.
   Results: In multivariate analyses, ever-use of statins was significantly inversely associated with development of HCC (Odds ratio (OR): 0.32, 95% CI: 0.15-0.67). No clear dose-response relationship was evident as statin use for <2 years (OR = 0.32, 95% CI = 0.13-0.83) and >2 years (OR = 0.31, 95CI% = 0.12-9.81) resulted in very similar ORs.
   Conclusions: The use of statins among populations in low-risk HCC areas may be associated with decreased risk of HCC. Published by Elsevier Ltd.
C1 [McGlynn, Katherine A.; Sahasrabuddhe, Vikrant V.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Divine, George W.; VanSlooten, Ashley; Wells, Karen; Alford, Sharon Hensley] Henry Ford Hlth Syst, Dept Publ Hlth Sci, Detroit, MI USA.
   [Engel, Lawrence S.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
   [Yood, Marianne Ulcickas] Boston Univ, Boston, MA 02215 USA.
RP McGlynn, KA (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, DHHS, 9609 Med Ctr Dr,Room 7E-104, Bethesda, MD 20892 USA.
EM mcglynnk@mail.nih.gov
OI Engel, Lawrence/0000-0001-9268-4830
FU National Cancer Institute (NIH)
FX This work was supported by Intramural Research Program of the National
   Cancer Institute (NIH).
NR 33
TC 9
Z9 9
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1877-7821
EI 1877-783X
J9 CANCER EPIDEMIOL
JI Cancer Epidemiol.
PD OCT
PY 2014
VL 38
IS 5
BP 523
EP 527
DI 10.1016/j.canep.2014.06.009
PG 5
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AW8HW
UT WOS:000346503300009
PM 25113938
ER

PT J
AU Ryan, BM
   Wolff, RK
   Valeri, N
   Khan, M
   Robinson, D
   Paone, A
   Bowmana, ED
   Lundgreen, A
   Caan, B
   Potter, J
   Brown, D
   Croce, C
   Slattery, ML
   Harris, CC
AF Ryan, Brid M.
   Wolff, Roger K.
   Valeri, Nicola
   Khan, Mohammed
   Robinson, Dillon
   Paone, Alessio
   Bowman, Elise D.
   Lundgreen, Abbie
   Caan, Bette
   Potter, John
   Brown, Derek
   Croce, Carlo
   Slattery, Martha L.
   Harris, Curtis C.
TI An analysis of genetic factors related to risk of inflammatory bowel
   disease and colon cancer
SO CANCER EPIDEMIOLOGY
LA English
DT Article
DE Inflammatory bowel disease; Colon cancer; STAT3
ID GENOME-WIDE ASSOCIATION; MOLECULAR PATHOLOGICAL EPIDEMIOLOGY;
   MULTIPLE-SCLEROSIS SUSCEPTIBILITY; CROHNS-DISEASE; ULCERATIVE-COLITIS;
   COLORECTAL-CANCER; ESCHERICHIA-COLI; MYELOPROLIFERATIVE NEOPLASMS;
   CORRELATED RESPONSES; STAT3 POLYMORPHISMS
AB Background and aims: Patients with inflammatory bowel disease (IBD) have a higher risk of developing colorectal cancer than the general population. Genome-wide association studies have identified and replicated several loci associated with risk of IBD; however, it is currently unknown whether these loci are also associated with colon cancer risk.
   Methods: We selected 15 validated SNPs associated with risk of either Crohn's disease, ulcerative colitis, or both in previous GWAS and tested whether these loci were also associated with colon cancer risk in a two-stage study design.
   Results: We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53. The SNP, which lies within intron 1 of the STAT3 gene, was associated with lower expression of STAT3 mRNA in TP53 wild-type, but not mutant, tumors.
   Conclusions: These data suggest that the STAT3 locus is associated with both IBD and cancer. Further understanding the function of this variant in relation to TP53 could possibly explain the role of this gene in autoimmunity and cancer. Furthermore, an analysis of this locus, specifically in a population with IBD, could help to resolve the relationship between this SNP and cancer. Published by Elsevier Ltd.
C1 [Ryan, Brid M.; Khan, Mohammed; Robinson, Dillon; Bowman, Elise D.; Brown, Derek; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Wolff, Roger K.; Lundgreen, Abbie; Slattery, Martha L.] Univ Utah, Dept Internal Med, Salt Lake City, UT 84132 USA.
   [Valeri, Nicola] Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England.
   [Paone, Alessio; Croce, Carlo] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA.
   [Caan, Bette] Kaiser Permanente Med Res Program, Dept Res, Oakland, CA 94612 USA.
   [Potter, John] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA.
   [Potter, John] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand.
   [Potter, John] Univ Washington, Dept Epidemiol, Seattle, WA 98109 USA.
RP Harris, CC (reprint author), NCI, Human Carcinogenesis Lab, Bldg 37,Room 3068,37 Convent Dr,MSC 4258, Bethesda, MD 20892 USA.
EM Curtis_Harris@nih.gov
OI valeri, nicola/0000-0002-5426-5683; Potter, John/0000-0001-5439-1500;
   Ryan, Brid/0000-0003-0038-131X
FU Intramural NIH HHS
NR 66
TC 11
Z9 11
U1 2
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1877-7821
EI 1877-783X
J9 CANCER EPIDEMIOL
JI Cancer Epidemiol.
PD OCT
PY 2014
VL 38
IS 5
BP 583
EP 590
DI 10.1016/j.canep.2014.07.003
PG 8
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AW8HW
UT WOS:000346503300018
PM 25132422
ER

PT J
AU SanGiovanni, JP
   Chew, EY
AF SanGiovanni, John Paul
   Chew, Emily Y.
TI Clinical Applications of Age-Related Macular Degeneration Genetics
SO COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; HIGH-RISK; PSYCHIATRIC-DISORDERS; COMPLEX
   TRAITS; CLASSIFICATION; IDENTIFICATION; HERITABILITY; DISEASE; BIOLOGY;
   VARIANT
AB Understanding genetic causes of age-related macular degeneration (AMD) will eventually yield effective discoveries and improvements in predictive/prognostic methods. These include, but are not limited to, reliable disease prediction (screening for increased discrimination of clinical risk), differential classification of AMD subtypes with biomarkers (development of risk-linked molecular taxonomies), selection of optimal preventive and therapeutic interventions (guided by a biologically meaningful understanding of treatment response), and drug dosing. In this review, we discuss clinical applications informed by key findings in AMD genetics, and provide commentary on leveraging extant and forthcoming evidence to improve AMD risk prediction, AMD classification, and knowledge on the genetic basis of drug activity and toxicity. Advances in translating AMD genetics findings for AMD risk prediction require development of a genetics-based causality for AMD incidence and progression. Molecular subtyping of AMD phenotypes requires a set of dynamic biomarkers presenting prognostic value; although these have yet to be identified, the formation of multidisciplinary teams and their participation in large-scale consortia may yield promising results. Drugs targeting complement and vascular endothelial growth factor (VEGF) systems are under evaluation, and forthcoming work on rare variants and noncoding DNA in AMD pathogenesis will likely reveal biochemical pathways enriched with AMD-associated genetic variants. Pharmacologic targets in these pathways may inform a rational and effective therapeutic approach to preventing and treating this sight-threatening disease.
C1 [SanGiovanni, John Paul; Chew, Emily Y.] NEI, Clin Trials Branch, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA.
RP Chew, EY (reprint author), NEI, Clin Trials Branch, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA.
EM jpsangio@post.harvard.edu; echew@nei.nih.gov
NR 36
TC 1
Z9 1
U1 0
U2 3
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 2157-1422
J9 CSH PERSPECT MED
JI Cold Spring Harb. Perspect. Med.
PD OCT
PY 2014
VL 4
IS 10
AR a017228
DI 10.1101/cshperspect.a017228
PG 10
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AW8OI
UT WOS:000346521400002
ER

PT J
AU Malandrino, N
   Miceli, A
   Leggio, L
   Mingrone, G
   Capristo, E
AF Malandrino, N.
   Miceli, A.
   Leggio, L.
   Mingrone, G.
   Capristo, E.
TI High Ghrelin Levels in Post-treatment Euthyroid Patients with
   Hashimoto's Thyroiditis: a Case-control Preliminary Study
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE ghrelin; thyroid hormones; Hashimoto's thyroiditis; inflammation;
   metabolism
ID FOOD-INTAKE; SERUM GHRELIN; HYPOTHYROID PATIENTS; ENERGY HOMEOSTASIS;
   ACYLATED PEPTIDE; BODY-COMPOSITION; PLASMA GHRELIN; L-THYROXINE;
   T-CELLS; HORMONE
AB Rationale: Hashimoto's thyroiditis is a chronic inflammatory condition often associated with changes in appetite and body composition. Ghrelin is an orexigenic peptide involved in the regulation of appetite and food intake. A possible role of ghrelin in mediating inflammation has been suggested. A few contrasting published data are available on the relationship between thyroid status and circulating ghrelin in patients affected by Hashimoto's thyroiditis. The aim of the present case-control study was to provide additional evidence on the relationship between thyroid status and plasma ghrelin levels in post-treatment euthyroid female patients with Hashimoto's thyroiditis, compared to healthy controls.
   Methods: 25 women [age 46.6 +/- 10.6 years; Body Mass Index 26.3 +/- 3.8 kg/m(2)] affected by overt hypothyroidism due to Hashimoto's thyroiditis were studied after thyroid hormones and body weight were already normalized for at least 2 months following L-thyroxine replacement. 25 healthy women (age 40.2 +/- 6.4 years; Body Mass Index 26.2 +/- 4.0 kg/m(2)) served as the control group. Blood levels of thyroid hormones, thyroid peroxidase antibodies, thyroglobulin antibodies and ghrelin were determined. Fat mass, fat-free mass and high-density lipoprotein cholesterol were also assessed.
   Results: Circulating ghrelin levels were significantly higher in patients vs. control subjects (p < 0.001). No differences were found in metabolic parameters (body mass index, fat mass, fat-free mass, high-density lipoprotein cholesterol) between groups.
   Conclusion: The present study provides additional evidence of hyperghrelinemia status in post-treatment euthyroid patients affected by Hashimoto's thyroiditis.
C1 [Malandrino, N.; Mingrone, G.; Capristo, E.] Univ Cattolica Sacro Cuore, Inst Internal Med, Metab Dis Outpatient Unit, I-00168 Rome, Italy.
   [Miceli, A.] Humanitas Clin & Res Ctr, Rozzano, MI, Italy.
   [Leggio, L.] NIAAA, Sect Clin Psychoneuroendocrinol & Neuropsychophar, Lab Clin & Translat Studies, NIH, Bethesda, MD USA.
   [Leggio, L.] NIDA, Intramural Res Program, NIH, Baltimore, MD USA.
   [Leggio, L.] Brown Univ, Ctr Alcohol & Addict Studies, Dept Behav & Social Sci, Providence, RI 02912 USA.
RP Malandrino, N (reprint author), Univ Cattolica Sacro Cuore, Inst Internal Med, Metab Dis Outpatient Unit, Lgo A Gemelli 8, I-00168 Rome, Italy.
EM noemimalandrino@gmail.com
RI Leggio, Lorenzo/M-2972-2016
NR 42
TC 1
Z9 1
U1 1
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD OCT
PY 2014
VL 122
IS 9
BP 540
EP 543
DI 10.1055/s-0034-1376965
PG 4
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AW4SZ
UT WOS:000346272000007
PM 24918532
ER

PT J
AU van Hees, F
   Zauber, AG
   Klabunde, CN
   Goede, SL
   Lansdorp-Vogelaar, I
   van Ballegooijen, M
AF van Hees, Frank
   Zauber, Ann G.
   Klabunde, Carrie N.
   Goede, S. Luuk
   Lansdorp-Vogelaar, Iris
   van Ballegooijen, Marjolein
TI The Appropriateness of More Intensive Colonoscopy Screening Than
   Recommended in Medicare Beneficiaries A Modeling Study
SO JAMA INTERNAL MEDICINE
LA English
DT Article
ID FECAL-OCCULT-BLOOD; COLORECTAL-CANCER MORTALITY; SERVICES TASK-FORCE;
   NEGATIVE COLONOSCOPY; AMERICAN-COLLEGE; LARGE-BOWEL; ELDERLY-PATIENTS;
   LIFE EXPECTANCY; LARGE-INTESTINE; POPULATION
AB IMPORTANCE Many Medicare beneficiaries undergo more intensive colonoscopy screening than recommended. Whether this is favorable for beneficiaries and efficient from a societal perspective is uncertain.
   OBJECTIVE To determine whether more intensive colonoscopy screening than recommended is favorable for Medicare beneficiaries (ie, whether it results in a net health benefit) and whether it is efficient from a societal perspective (ie, whether the net health benefit justifies the additional resources required).
   DESIGN, SETTING, AND PARTICIPANTS Microsimulation modeling study of 65-year-old Medicare beneficiaries at average risk for colorectal cancer (CRC) and with an average life expectancy who underwent a screening colonoscopy at 55 years with negative results.
   INTERVENTIONS Colonoscopy screening as recommended by guidelines (ie, at 65 and 75 years) vs scenarios with a shorter screening interval (5 or 3 instead of 10 years) or in which screening was continued to 85 or 95 years.
   MAIN OUTCOMES AND MEASURES Quality-adjusted life-years (QALYs) gained (measure of net health benefit); additional colonoscopies required per additional QALY gained and additional costs per additional QALY gained (measures of efficiency).
   RESULTS Screening previously screened Medicare beneficiaries more intensively than recommended resulted in only small increases in CRC deaths prevented and life-years gained. In comparison, the increases in colonoscopies performed and colonoscopy-related complications experienced were large. As a result, all scenarios of more intensive screening than recommended resulted in a loss of QALYs, rather than a gain (ie, a net harm). The only exception was shortening the screening interval from 10 to 5 years, which resulted in 0.7 QALYs gained per 1000 beneficiaries. However, this scenario was inefficient because it required no less than 909 additional colonoscopies and an additional $711 000 per additional QALY gained. Results in previously unscreened beneficiaries were slightly less unfavorable, but conclusions were identical.
   CONCLUSIONS AND RELEVANCE Screening Medicare beneficiaries more intensively than recommended is not only inefficient from a societal perspective; often it is also unfavorable for those being screened. This study provides evidence and a clear rationale for clinicians and policy makers to actively discourage this practice.
C1 [van Hees, Frank; Goede, S. Luuk; Lansdorp-Vogelaar, Iris; van Ballegooijen, Marjolein] Erasmus Univ, Med Ctr, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands.
   [Zauber, Ann G.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
   [Klabunde, Carrie N.] NCI, Hlth Serv & Econ Branch, Appl Res Program, Bethesda, MD 20892 USA.
RP van Hees, F (reprint author), Erasmus Univ, Med Ctr, Dept Publ Hlth, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM f.vanhees@erasmusmc.nl
FU National Cancer Institute [HHSN261201000628P, HHSN261201000485P];
   National Cancer Institute as part of the Cancer Intervention and
   Surveillance Modeling Network (CISNET) [UO1CA152959]
FX This study was made possible by contracts HHSN261201000628P and
   HHSN261201000485P from the National Cancer Institute. This study was
   partially made possible by grant UO1CA152959 from the National Cancer
   Institute as part of the Cancer Intervention and Surveillance Modeling
   Network (CISNET), which supported the development of MISCAN-Colon.
NR 49
TC 9
Z9 9
U1 0
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD OCT
PY 2014
VL 174
IS 10
BP 1568
EP 1576
DI 10.1001/jamainternmed.2014.3889
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA AU9JS
UT WOS:000345909100013
PM 25133641
ER

PT J
AU Barbosa, IG
   Morato, IB
   Huguet, RB
   Rocha, FL
   Machado-Vieira, R
   Teixeira, AL
AF Barbosa, Izabela G.
   Morato, Isabela B.
   Huguet, Rodrigo B.
   Rocha, Fabio L.
   Machado-Vieira, Rodrigo
   Teixeira, Antonio L.
TI Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in
   mania
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Neurotrophin; mania; depression; bipolar disorder; biomarker
ID INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; DEPRESSIVE EPISODES; ILLNESS
   ACTIVITY; DSM-IV; BIOMARKERS; MOOD; MINI
AB Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).
   Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).
   Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p<.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.
   Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.
C1 [Barbosa, Izabela G.; Morato, Isabela B.; Teixeira, Antonio L.] Univ Fed Minas Gerais UFMJ, Sch Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil.
   [Huguet, Rodrigo B.; Rocha, Fabio L.] IPSEMG, Belo Horizonte, MG, Brazil.
   [Machado-Vieira, Rodrigo] NIMH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 USA.
   [Machado-Vieira, Rodrigo] Univ Sao Paulo, Inst & Dept Psychiat, Lab Neurosci LIM 27, BR-09500900 Sao Paulo, Brazil.
RP Barbosa, IG (reprint author), Univ Fed Minas Gerais, Fac Med, Lab Interdisciplinar Invest Med, Av Alfredo Balena,190,Sala 281, BR-30130100 Belo Horizonte, MG, Brazil.
EM izabelagb@gmail.com
RI MACHADO-VIEIRA, RODRIGO/D-8293-2012
OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX This work was partly funded by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG). IGB is the recipient of a postdoctoral
   scholarship from Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES).
NR 15
TC 1
Z9 1
U1 0
U2 1
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD OCT-DEC
PY 2014
VL 36
IS 4
BP 340
EP 343
DI 10.1590/1516-4446-2014-1380
PG 4
WC Psychiatry
SC Psychiatry
GA AW1UJ
UT WOS:000346075800010
PM 25076171
ER

PT J
AU Feigelson, HS
   Goddard, KAB
   Hollombe, C
   Tingle, SR
   Gillanders, EM
   Mechanic, LE
   Nelson, SA
AF Feigelson, Heather Spencer
   Goddard, Katrina A. B.
   Hollombe, Celine
   Tingle, Sharna R.
   Gillanders, Elizabeth M.
   Mechanic, Leah E.
   Nelson, Stefanie A.
TI Approaches to integrating germline and tumor genomic data in cancer
   research
SO CARCINOGENESIS
LA English
DT Review
ID COMMON GENETIC-VARIANTS; BREAST-CANCER; ASSOCIATION CONSORTIUM; WIDE
   ASSOCIATION; GASTRIC-CANCER; SUSCEPTIBILITY LOCUS; MOLECULAR PORTRAITS;
   RISK LOCI; EXPRESSION; MEDULLOBLASTOMA
AB Cancer is characterized by a diversity of genetic and epigenetic alterations occurring in both the germline and somatic (tumor) genomes. Hundreds of germline variants associated with cancer risk have been identified, and large amounts of data identifying mutations in the tumor genome that participate in tumorigenesis have been generated. Increasingly, these two genomes are being explored jointly to better understand how cancer risk alleles contribute to carcinogenesis and whether they influence development of specific tumor types or mutation profiles. To understand how data from germline risk studies and tumor genome profiling is being integrated, we reviewed 160 articles describing research that incorporated data from both genomes, published between January 2009 and December 2012, and summarized the current state of the field. We identified three principle types of research questions being addressed using these data: (i) use of tumor data to determine the putative function of germline risk variants; (ii) identification and analysis of relationships between host genetic background and particular tumor mutations or types; and (iii) use of tumor molecular profiling data to reduce genetic heterogeneity or refine phenotypes for germline association studies. We also found descriptive studies that compared germline and tumor genomic variation in a gene or gene family, and papers describing research methods, data sources, or analytical tools. We identified a large set of tools and data resources that can be used to analyze and integrate data from both genomes. Finally, we discuss opportunities and challenges for cancer research that integrates germline and tumor genomics data.
C1 [Feigelson, Heather Spencer] Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA.
   [Goddard, Katrina A. B.; Hollombe, Celine] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA.
   [Tingle, Sharna R.; Gillanders, Elizabeth M.; Mechanic, Leah E.; Nelson, Stefanie A.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Rockville, MD 20850 USA.
RP Nelson, SA (reprint author), NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Rockville, MD 20850 USA.
EM stefanie.nelson@nih.gov
FU SAIC-Frederick, Inc.; NCI-Frederick, Frederick, Maryland; National
   Cancer Institute [HHSN261200800001E]
FX SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21709, National
   Cancer Institute contract (HHSN261200800001E) to K.G., H.F. and C.H.
NR 44
TC 4
Z9 4
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0143-3334
EI 1460-2180
J9 CARCINOGENESIS
JI Carcinogenesis
PD OCT
PY 2014
VL 35
IS 10
BP 2157
EP 2163
DI 10.1093/carcin/bgu165
PG 7
WC Oncology
SC Oncology
GA AU8EY
UT WOS:000345830400001
PM 25115441
ER

PT J
AU Bi, HC
   Pan, YZ
   Qiu, JX
   Krausz, KW
   Li, F
   Johnson, CH
   Jiang, CT
   Gonzalez, FJ
   Yu, AM
AF Bi, Hui-Chang
   Pan, Yu-Zhuo
   Qiu, Jing-Xin
   Krausz, Kristopher W.
   Li, Fei
   Johnson, Caroline H.
   Jiang, Chang-Tao
   Gonzalez, Frank J.
   Yu, Ai-Ming
TI N-methylnicotinamide and nicotinamide N-methyltransferase are associated
   with microRNA-1291-altered pancreatic carcinoma cell metabolome and
   suppressed tumorigenesis
SO CARCINOGENESIS
LA English
DT Article
ID HEPATOCYTE NUCLEAR FACTOR-1-BETA; THYROID-CANCER CELLS; DUCTAL
   ADENOCARCINOMA; MICRORNA EXPRESSION; TUMOR-DEVELOPMENT; GENE-EXPRESSION;
   POOR-PROGNOSIS; METHYLATION; 1-METHYLNICOTINAMIDE; METASTASIS
AB The cell metabolome comprises abundant information that may be predictive of cell functions in response to epigenetic or genetic changes at different stages of cell proliferation and metastasis. An unbiased ultra-performance liquid chromatography-mass spectrometry-based metabolomics study revealed a significantly altered metabolome for human pancreatic carcinoma PANC-1 cells with gain-of-function non-coding microRNA-1291 (miR-1291), which led to a lower migration and invasion capacity as well as suppressed tumorigenesis in a xenograft tumor mouse model. A number of metabolites, including N-methylnicotinamide, involved in nicotinamide metabolism, and l-carnitine, isobutyryl-carnitine and isovaleryl-carnitine, involved in fatty acid metabolism, were elevated in miR-1291-expressing PANC-1. Notably, N-methylnicotinamide was elevated to the greatest extent, and this was associated with a sharp increase in nicotinamide N-methyltransferase (NNMT) mRNA level in miR-1291-expressing PANC-1 cells. In addition, expression of NNMT mRNA was inversely correlated with pancreatic tumor size in the xenograft mouse model. These results indicate that miR-1291-altered PANC-1 cell function is associated with the increase in N-methylnicotinamide level and NNMT expression, and in turn NNMT may be indicative of the extent of pancreatic carcinogenesis.
C1 [Bi, Hui-Chang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
   [Bi, Hui-Chang; Krausz, Kristopher W.; Li, Fei; Johnson, Caroline H.; Jiang, Chang-Tao; Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Pan, Yu-Zhuo; Yu, Ai-Ming] SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA.
   [Pan, Yu-Zhuo; Yu, Ai-Ming] UC Davis Med Ctr, Dept Biochem & Mol Med, Sacramento, CA 95817 USA.
   [Qiu, Jing-Xin] Roswell Pk Canc Inst, Dept Pathol, Buffalo, NY 14263 USA.
RP Yu, AM (reprint author), UC Davis Med Ctr, Dept Biochem & Mol Med, 2700 Stockton Blvd,Suite 2132, Sacramento, CA 95817 USA.
EM aimyu@ucdavis.edu
FU National Cancer Institute Intramural Research Program, Center for Cancer
   Research [1ZIABC005708, 1ZIABC005562]; National Institute on Drug Abuse
   and National Cancer Institute, National Institutes of Health
   [R01DA021172, U01CA175315]; China Scholarship Council [2010844039]
FX National Cancer Institute Intramural Research Program, Center for Cancer
   Research (1ZIABC005708 and 1ZIABC005562 to F.J.G.); National Institute
   on Drug Abuse and National Cancer Institute, National Institutes of
   Health (Award R01DA021172 and U01CA175315 to A.-M.Y.); China Scholarship
   Council for the State Scholarship Fund (Award number 2010844039 to
   H.-C.B.).
NR 58
TC 14
Z9 14
U1 2
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0143-3334
EI 1460-2180
J9 CARCINOGENESIS
JI Carcinogenesis
PD OCT
PY 2014
VL 35
IS 10
BP 2264
EP 2272
DI 10.1093/carcin/bgu174
PG 9
WC Oncology
SC Oncology
GA AU8EY
UT WOS:000345830400012
PM 25115443
ER

PT J
AU Balansky, R
   Izzotti, A
   D'Agostini, F
   Longobardi, M
   Micale, RT
   La Maestra, S
   Camoirano, A
   Ganchev, G
   Iltcheva, M
   Steele, VE
   De Flora, S
AF Balansky, Roumen
   Izzotti, Alberto
   D'Agostini, Francesco
   Longobardi, Mariagrazia
   Micale, Rosanna T.
   La Maestra, Sebastiano
   Camoirano, Anna
   Ganchev, Gancho
   Iltcheva, Marietta
   Steele, Vernon E.
   De Flora, Silvio
TI Assay of lapatinib in murine models of cigarette smoke carcinogenesis
SO CARCINOGENESIS
LA English
DT Article
ID REFRACTORY CNS MALIGNANCIES; TYROSINE KINASE INHIBITORS; BRAIN-TUMOR
   CONSORTIUM; PHASE-I TRIAL; LUNG-CANCER; CHEMOPREVENTIVE AGENTS; MICRORNA
   EXPRESSION; PHENETHYL ISOTHIOCYANATE; N-ACETYLCYSTEINE; BREAST-CANCER
AB Lapatinib, a dual tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2), is prescribed for the treatment of patients with metastatic breast cancer overexpressing HER-2. Involvement of this drug in pulmonary carcinogenesis has been poorly investigated. We used murine models suitable to evaluate cigarette smoke-related molecular and histopathological alterations. A total of 481 Swiss H mice were used. The mice were exposed to mainstream cigarette smoke (MCS) during the first four months of life. After 10 weeks, MCS caused an elevation of bulky DNA adducts, oxidative DNA damage and an extensive downregulation of microRNAs in lung. After four months, an increase in micronucleus frequency was observed in peripheral blood erythrocytes. After 7.5 months, histopathological alterations were detected in the lung, also including benign tumors and malignant tumors, and in the urinary tract. A subchronic toxicity study assessed the non-toxic doses of lapatinib, administered daily with the diet after weaning. After 10 weeks, lapatinib significantly attenuated the MCS-related nucleotide changes and upregulated several low-intensity microRNAs in lung. The drug poorly affected the MCS systemic genotoxicity and had modest protective effects on MCS-induced preneoplastic lesions in lung and kidney, when administered under conditions that temporarily mimicked interventions either in current smokers or exsmokers. On the other hand, it caused some toxicity to the liver. Thus, on the whole, lapatinib appears to have a low impact in the smoke-related lung carcinogenesis models used, especially in terms of tumorigenic response.
C1 [Balansky, Roumen; Izzotti, Alberto; D'Agostini, Francesco; Longobardi, Mariagrazia; Micale, Rosanna T.; La Maestra, Sebastiano; Camoirano, Anna; De Flora, Silvio] Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy.
   [Balansky, Roumen; Ganchev, Gancho; Iltcheva, Marietta] Natl Oncol Ctr, Sofia 1756, Bulgaria.
   [Izzotti, Alberto] IRCCS AOU San Martino IST, I-16132 Genoa, Italy.
   [Steele, Vernon E.] NCI, Canc Prevent Div, Rockville, MD 20892 USA.
RP De Flora, S (reprint author), Univ Genoa, Dept Hlth Sci, Via A Pastore 1, I-16132 Genoa, Italy.
EM sdf@unige.it
OI izzotti, alberto/0000-0002-8588-0347
FU National Cancer Institute [HHSN-261200433000C]; Bulgarian Ministry of
   Education, Youth and Science
FX National Cancer Institute (contract HHSN-261200433000C); Bulgarian
   Ministry of Education, Youth and Science.
NR 51
TC 6
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0143-3334
EI 1460-2180
J9 CARCINOGENESIS
JI Carcinogenesis
PD OCT
PY 2014
VL 35
IS 10
BP 2300
EP 2307
DI 10.1093/carcin/bgu154
PG 8
WC Oncology
SC Oncology
GA AU8EY
UT WOS:000345830400016
PM 25053627
ER

PT J
AU Feigin, V
   Forouzanfar, MH
   Krishnamurthi, R
   Mensah, G
   Connor, M
   Bennett, DA
   Moran, A
   Naghavi, M
   Sacco, R
   Murray, C
AF Feigin, V.
   Forouzanfar, M. H.
   Krishnamurthi, R.
   Mensah, G.
   Connor, M.
   Bennett, D. A.
   Moran, A.
   Naghavi, M.
   Sacco, R.
   Murray, C.
TI Global burden of stroke - An update
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Meeting Abstract
C1 [Feigin, V.; Krishnamurthi, R.] AUT Univ, Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand.
   [Forouzanfar, M. H.; Naghavi, M.; Murray, C.] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA.
   [Mensah, G.] NHLBI, Heart Lung & Blood Inst, NIH, Bethesda, MD 20892 USA.
   [Connor, M.] Univ Edinburgh, Div Clin Neurosci, Edinburgh, Midlothian, Scotland.
   [Bennett, D. A.] Univ Oxford, Clin Trial Serv Unit, Oxford, England.
   [Bennett, D. A.] Univ Oxford, Epidemiol Studies Unit, Oxford, England.
   [Moran, A.] Columbia Univ, Med Ctr, Div Gen Med, New York, NY USA.
   [Sacco, R.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
NR 0
TC 0
Z9 0
U1 4
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD OCT
PY 2014
VL 9
SU 3
SI SI
MA WSC-1639
BP 5
EP 5
PG 1
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA AU7GB
UT WOS:000345767700015
ER

PT J
AU Howard, VJ
   Judd, SE
   Kleindorfer, DO
   McClure, LA
   Safford, MM
   Rhodes, JD
   Cushman, M
   Moy, CS
   Kissela, BM
   Howard, G
AF Howard, V. J.
   Judd, S. E.
   Kleindorfer, D. O.
   McClure, L. A.
   Safford, M. M.
   Rhodes, J. D.
   Cushman, M.
   Moy, C. S.
   Kissela, B. M.
   Howard, G.
TI Association of sex and race with incident stroke: The Reasons for
   Geographic and Racial Differences in Stroke (REGARDS) Study
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Meeting Abstract
C1 [Howard, V. J.; Judd, S. E.; McClure, L. A.; Safford, M. M.; Rhodes, J. D.; Howard, G.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Kleindorfer, D. O.; Kissela, B. M.] Univ Cincinnati, Cincinnati, OH USA.
   [Cushman, M.] Univ Vermont, Burlington, VT USA.
   [Moy, C. S.] NINDS, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD OCT
PY 2014
VL 9
SU 3
SI SI
MA WSC-0812
BP 158
EP 158
PG 1
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA AU7GB
UT WOS:000345767700439
ER

PT J
AU Howard, G
   Kissela, BM
   Kleindorfer, DO
   Soliman, EZ
   McClure, LA
   Judd, SE
   Lackland, DT
   Cushman, M
   Moy, CS
   Howard, VJ
AF Howard, G.
   Kissela, B. M.
   Kleindorfer, D. O.
   Soliman, E. Z.
   McClure, L. A.
   Judd, S. E.
   Lackland, D. T.
   Cushman, M.
   Moy, C. S.
   Howard, V. J.
TI Differences in risk factors for first versus recurrent stroke
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Meeting Abstract
C1 [Howard, G.; McClure, L. A.; Judd, S. E.; Howard, V. J.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Kissela, B. M.; Kleindorfer, D. O.] Univ Cincinnati, Cincinnati, OH USA.
   [Soliman, E. Z.] Wake Forest Univ, Winston Salem, NC 27109 USA.
   [Lackland, D. T.] Med Univ S Carolina, Charleston, SC 29425 USA.
   [Cushman, M.] Univ Vermont, Burlington, VT USA.
   [Moy, C. S.] NINDS, NIH, Bethesda, MD 20892 USA.
RI Banach, Maciej/A-1271-2009
OI Banach, Maciej/0000-0001-6690-6874
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD OCT
PY 2014
VL 9
SU 3
SI SI
MA WSC-0583
BP 159
EP 159
PG 1
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA AU7GB
UT WOS:000345767700440
ER

PT J
AU Palesch, YY
   Martin, RL
   Speiser, JL
   Hill, MD
   Moy, CS
   Barsan, WG
   Ginsberg, MD
AF Palesch, Y. Y.
   Martin, R. L.
   Speiser, J. L.
   Hill, M. D.
   Moy, C. S.
   Barsan, W. G.
   Ginsberg, M. D.
TI Analysis of the 7-year alias parts 1 and 2 trials suggests adaptive
   designs may be considered for future trials to account for evolving
   medical management of stroke
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Meeting Abstract
C1 [Palesch, Y. Y.; Martin, R. L.; Speiser, J. L.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA.
   [Hill, M. D.] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada.
   [Moy, C. S.] NINDS, Off Clin Res, Bethesda, MD 20892 USA.
   [Barsan, W. G.] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA.
   [Ginsberg, M. D.] Univ Miami, Dept Neurol, Miami, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD OCT
PY 2014
VL 9
SU 3
SI SI
MA WSC-0435
BP 217
EP 217
PG 1
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA AU7GB
UT WOS:000345767700614
ER

PT J
AU Tanaka, M
   Gehan, E
   Chen, MY
   Wang, JHY
AF Tanaka, Miho
   Gehan, Edmund
   Chen, Mei-yu
   Wang, Judy Huei-yu
TI Hepatitis B Screening Practice among Older Chinese in the Greater
   Washington, DC, Area
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Article
DE Chinese Americans; hepatitis B screening; hepatitis B virus infection;
   self-care beliefs
ID VIRUS INFECTION; ASIAN-AMERICAN; LIVER-CANCER; UNITED-STATES;
   VACCINATION; KNOWLEDGE; HEALTH; WOMEN; IMMIGRANTS; INTERVENTION
AB Objectives: Older Chinese Americans are at greater risk of contracting hepatitis B virus (HBV) because they were born before the implementation of universal childhood vaccination policies. This study examined the prevalence of HBV screening, test results, and predictors of HBV screening among older Chinese.
   Methods: Two hundred fifty-two Chinese immigrants (older than 50 years) recruited from Chinese-speaking physicians' offices in the Washington, DC, area participated in a cancer screening questionnaire. Descriptive statistics and hierarchical logistic regressions were conducted.
   Results: Among the 164 participants (65%) who underwent HBV screening, 66% reported that they were susceptible to HBV infection. Stronger self-care beliefs, longer US residency, lower HBV knowledge, and lack of physician recommendations were independently and negatively associated with HBV screening.
   Conclusions: Many older Chinese did not adhere to HBV screening guidelines because of cultural views and information deficiency. Culturally appropriate interventions aimed to enhance their knowledge and communication with physicians about HBV are needed for promoting screening.
C1 NCI, Kelly Serv Contract Program Support, Div Canc Prevent & Populat Sci, Rockville, MD USA.
   Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Biostat, Washington, DC 20007 USA.
   Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Bioinformat, Washington, DC 20007 USA.
   Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Biomath, Washington, DC 20007 USA.
   Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Canc Prevent & Control Program, Washington, DC 20007 USA.
RP Wang, JHY (reprint author), Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Oncol,Canc Prevent & Control Program, 3300 Whitehaven St NW,Suite 4100, Washington, DC 20007 USA.
EM jw235@georgetown.edu
FU National Cancer Institute [R01CA121023]
FX This work was funded by National Cancer Institute R01CA121023. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the funding agency.
NR 33
TC 1
Z9 1
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD OCT
PY 2014
VL 107
IS 10
BP 655
EP 660
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AU6WZ
UT WOS:000345743400012
PM 25279872
ER

PT J
AU Spiegel, AM
   Sewal, AS
   Rapp, PR
AF Spiegel, Amy M.
   Sewal, Angila S.
   Rapp, Peter R.
TI Epigenetic contributions to cognitive aging: disentangling mindspan and
   lifespan
SO LEARNING & MEMORY
LA English
DT Review
ID HISTONE DEACETYLASE INHIBITORS; LONG-TERM-MEMORY; AGED RATS; DNA
   METHYLATION; DENTATE GYRUS; SYNAPTIC PLASTICITY; AXOSPINOUS SYNAPSES;
   ALZHEIMERS-DISEASE; RHESUS-MONKEYS; HIPPOCAMPAL
AB Epigenetic modifications of chromatin structure provide a mechanistic interface for gene-environment interactions that impact the individualization of health trajectories across the lifespan. A growing body of research indicates that dysfunctional epigenetic regulation contributes to poor cognitive outcomes among aged populations. Here we review neuroepigenetic research as it relates to cognitive aging, focusing specifically on memory function mediated by the hippocampal system. Recent work that differentiates epigenetic contributions to chronological aging from influences on mindspan, or the preservation of normal cognitive abilities across the lifespan, is also highlighted. Together, current evidence indicates that while age-related memory impairment is associated with dysfunction in the coordinated regulation of chromatin modification, animal models that show individual differences in cognitive outcome underscore the enormous mechanistic complexity that surrounds epigenetic dynamics in the aged hippocampus.
C1 [Spiegel, Amy M.; Sewal, Angila S.; Rapp, Peter R.] NIA, Neurocognit Aging Sect, Lab Behav Neurosci, Baltimore, MD 21224 USA.
RP Rapp, PR (reprint author), NIA, Neurocognit Aging Sect, Lab Behav Neurosci, Baltimore, MD 21224 USA.
EM rappp@mail.nih.gov
FU National Institute on Aging
FX We thank Lisa Taxier for editorial input and members of the
   Neurocognitive Aging Section for helpful discussion. This work was
   supported by the Intramural Research Program of the National Institute
   on Aging.
NR 69
TC 5
Z9 6
U1 2
U2 11
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1072-0502
EI 1549-5485
J9 LEARN MEMORY
JI Learn. Mem.
PD OCT
PY 2014
VL 21
IS 10
BP 569
EP 574
DI 10.1101/lm.033506.113
PG 6
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AS1RI
UT WOS:000344057800012
PM 25227252
ER

PT J
AU Samuels, J
   Grados, MA
   Riddle, MA
   Bienvenu, OJ
   Goes, FS
   Cullen, B
   Wang, Y
   Greenberg, BD
   Fyer, AJ
   McCracken, JT
   Geller, D
   Murphy, DL
   Knowles, JA
   Rasmussen, SA
   McLaughlin, NC
   Piacentini, J
   Pauls, DL
   Stewart, SE
   Shugart, YY
   Maher, B
   Pulver, AE
   Nestadt, G
AF Samuels, Jack
   Grados, Marco A.
   Riddle, Mark A.
   Bienvenu, O. Joseph
   Goes, Fernando S.
   Cullen, Bernadette
   Wang, Ying
   Greenberg, Benjamin D.
   Fyer, Abby J.
   McCracken, James T.
   Geller, Dan
   Murphy, Dennis L.
   Knowles, James A.
   Rasmussen, Steven A.
   McLaughlin, Nicole C.
   Piacentini, John
   Pauls, David L.
   Stewart, S. Evelyn
   Shugart, Yin-Yao
   Maher, Brion
   Pulver, Ann E.
   Nestadt, Gerald
TI Hoarding in children and adolescents with obsessive-compulsive disorder
SO JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS
LA English
DT Article
DE OCD; Children; Adolescents; Hoarding; Social reciprocity; Indecision
ID OCD COLLABORATIVE GENETICS; FACTOR-ANALYZED SYMPTOM; YOUNG-CHILDREN;
   LIFE EVENTS; BEHAVIOR; DIMENSIONS; AUTISM; INDIVIDUALS; SAMPLE;
   SCHIZOPHRENIA
AB Compared to studies in adults, there have been few studies of hoarding in children and adolescents with obsessive-compulsive disorder (OCD). In the current study, we evaluated OCD clinical features, Axis I disorders, and social reciprocity scores in 641 children and adolescents with OCD, of whom 163 (25%) had hoarding compulsions and 478 did not. We found that, as a group, youth with hoarding had an earlier age at onset and more severe lifetime OCD symptoms, poorer insight, more difficulty making decisions and completing tasks, and more overall impairment. The hoarding group also had a greater lifetime prevalence of panic disorder, specific phobia, burette disorder, and tics. As measured with the Social Reciprocity Scale, the hoarding group had more severe deficits in parent-rated domains of social communication, social motivation, and restricted interests and repetitive behavior. In a multivariable model, the overall social reciprocity score, age at onset of OCD symptoms, symmetry obsessions, and indecision were independently related to hoarding in these children and adolescents with OCD. These features should be considered as candidate risk factors for the development of hoarding behavior in pediatric OCD. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Samuels, Jack; Grados, Marco A.; Riddle, Mark A.; Bienvenu, O. Joseph; Goes, Fernando S.; Cullen, Bernadette; Wang, Ying; Pulver, Ann E.; Nestadt, Gerald] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Greenberg, Benjamin D.; Rasmussen, Steven A.; McLaughlin, Nicole C.] Butler Hosp, Brown Med Sch, Dept Psychiat & Behav Sci, Providence, RI 02906 USA.
   [Fyer, Abby J.] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA.
   [Fyer, Abby J.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [McCracken, James T.; Piacentini, John] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
   [Geller, Dan] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Murphy, Dennis L.] NIMH, Clin Sci Lab, NIH, Bethesda, MD 20892 USA.
   [McCracken, James T.] Univ So Calif, Sch Med, Dept Psychiat, Los Angeles, CA USA.
   [Murphy, Dennis L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Pauls, David L.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
   [Pauls, David L.] Harvard Univ, Sch Med, Boston, MA USA.
   [Stewart, S. Evelyn] Univ British Columbia, Dept Psychiat, Fac Med, Vancouver, BC, Canada.
   [Shugart, Yin-Yao] NIMH, Unit Stat Genom, Div Intramural Res, Bethesda, MD 20892 USA.
   [Maher, Brion] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA.
RP Samuels, J (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
EM jacks@jhmi.edu
OI Samuels, Jack/0000-0002-6715-7905; Stewart, S.
   Evelyn/0000-0002-0994-6383
FU National Institutes of Health [MH50214, MH071507, MH79487, MH079488,
   MH079489, MH07 9494, K23-MH-64543, NIH/NCRR/OPD-GCRC RR00052]; James E.
   Marshall OCD Foundation
FX This work was supported by National Institutes of Health grants MH50214,
   MH071507, MH79487, MH079488, MH079489, MH07 9494, K23-MH-64543,
   NIH/NCRR/OPD-GCRC RR00052, and by the James E. Marshall OCD Foundation.
   The National Institutes of Health and the James E. Marshall OCD
   Foundation had no role in the study design, collection, data analysis
   and interpretation, or writing the manuscript.
NR 63
TC 6
Z9 6
U1 7
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2211-3649
J9 J OBSESS-COMPULS REL
JI J. Obsessive-Compuls. Relat. Disord.
PD OCT
PY 2014
VL 3
IS 4
BP 325
EP 331
DI 10.1016/j.jocrd.2014.08.001
PG 7
WC Psychiatry
SC Psychiatry
GA AU4TN
UT WOS:000345604400004
PM 25309849
ER

PT J
AU Post, RM
AF Post, Robert M.
TI This issue: Part 2: Differentiating Pediatric Bipolar Disorder from
   Attention-Deficit/Hyperactivity Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Editorial Material
C1 [Post, Robert M.] George Washington Univ, Washington, DC USA.
   [Post, Robert M.] Bipolar Collaborat Network, Bethesda, MD 20814 USA.
   [Post, Robert M.] NIMH, Bethesda, MD USA.
   [Post, Robert M.] Stanley Fdn Bipolar Network, Bethesda, MD USA.
RP Post, RM (reprint author), Bipolar Collaborat Network, 5415 W Cedar Lane,Suite 201B, Bethesda, MD 20814 USA.
EM robert.post@speakeasy.net
NR 3
TC 0
Z9 0
U1 2
U2 4
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
EI 1938-2456
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD OCT
PY 2014
VL 44
IS 10
BP 455
EP 455
DI 10.3928/00485713-20141003-03
PG 1
WC Psychiatry
SC Psychiatry
GA AT5GZ
UT WOS:000344973300003
ER

PT J
AU Engels, EA
   Wacholder, S
   Katki, HA
   Chaturvedi, AK
AF Engels, Eric A.
   Wacholder, Sholom
   Katki, Hormuzd A.
   Chaturvedi, Anil K.
TI Tumor-Based Case-Control Studies of Infection and Cancer: Muddling the
   When and Where of Molecular Epidemiology
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Editorial Material
ID HELICOBACTER-PYLORI INFECTION; HUMAN-PAPILLOMAVIRUS; GASTRIC-CANCER;
   RISK; ASSOCIATION; METAANALYSIS; CARCINOMA; HEAD
AB We describe the "tumor-based case-control" study as a type of epidemiologic study used to evaluate associations between infectious agents and cancer. These studies assess exposure using diseased tissues from affected individuals (i.e., evaluating tumor tissue for cancer cases), but they must utilize nondiseased tissues to assess control subjects, who do not have the disease of interest. This approach can lead to exposure misclassification in two ways. First, concerning the "when" of exposure assessment, retrospective assessment of tissues may not accurately measure exposure at the key earlier time point (i.e., during the etiologic window). Second, concerning the "where" of exposure assessment, use of different tissues in cases and controls can have different accuracy for detecting the exposure (i.e., differential exposure misclassification). We present an example concerning the association of human papillomavirus with various cancers, where tumor-based case-control studies likely overestimate risk associated with infection. In another example, we illustrate how tumor-based case-control studies of Helicobacter pylori and gastric cancer underestimate risk. Tumor-based case-control studies can demonstrate infection within tumor cells, providing qualitative information about disease etiology. However, measures of association calculated in tumor-based case-control studies are prone to over- or underestimating the relationship between infections and subsequent cancer risk. (C)2014 AACR.
C1 [Engels, Eric A.; Wacholder, Sholom; Katki, Hormuzd A.; Chaturvedi, Anil K.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
RP Engels, EA (reprint author), NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr,Room 6E226 MSC 9767, Bethesda, MD 20892 USA.
EM engelse@exchange.nih.gov
RI Katki, Hormuzd/B-4003-2015; Chaturvedi, Anil/J-2024-2015
OI Chaturvedi, Anil/0000-0003-2696-8899
FU Intramural NIH HHS [ZIA CP010150-14]
NR 24
TC 2
Z9 2
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD OCT
PY 2014
VL 23
IS 10
BP 1959
EP 1964
DI 10.1158/1055-9965.EPI-14-0282
PG 6
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AT9XP
UT WOS:000345277400001
PM 25063520
ER

PT J
AU Zapka, JM
   Edwards, HM
   Chollette, V
   Taplin, SH
AF Zapka, Jane M.
   Edwards, Heather M.
   Chollette, Veronica
   Taplin, Stephen H.
TI Follow-up to Abnormal Cancer Screening Tests: Considering the Multilevel
   Context of Care
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Editorial Material
ID CLIENT-DIRECTED INTERVENTIONS; OF-THE-ART; COLORECTAL-CANCER;
   UNITED-STATES; INFORMATION-TECHNOLOGY; RESEARCH PERSPECTIVE;
   RANDOMIZED-TRIAL; INSURANCE STATUS; QUALITY-CARE; WOMEN
AB The call for multilevel interventions to improve the quality of follow-up to abnormal cancer screening has been out for a decade, but published work emphasizes individual approaches, and conceptualizations differ regarding the definition of levels. To investigate the scope and methods being undertaken in this focused area of follow-up to abnormal tests (breast, colon, cervical), we reviewed recent literature and grants (2007-2012) funded by the National Cancer Institute. A structured search yielded 16 grants with varying definitions of "follow-up" (e.g., completion of recommended tests, time to diagnosis); most included minority racial/ethnic group participants. Ten grants concentrated on measurement/intervention development and 13 piloted or tested interventions (categories not mutually exclusive). All studies considered patient-level factors and effects. Although some directed interventions at provider levels, few measured group characteristics and effects of interventions on the providers or levels other than the patient. Multilevel interventions are being proposed, but clarity about endpoints, definition of levels, and measures is needed. The differences in the conceptualization of levels and factors that affect practice need empirical exploration, and we need to measure their salient characteristics to advance our understanding of how context affects cancer care delivery in a changing practice and policy environment. (C)2014 AACR.
C1 [Zapka, Jane M.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA.
   [Edwards, Heather M.] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Clin Res Directorate CMRP, Frederick, MD USA.
   [Chollette, Veronica; Taplin, Stephen H.] NCI, Proc Care Res Branch, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
RP Zapka, JM (reprint author), Med Univ S Carolina, Dept Publ Hlth Sci, 135 Cannon St,Room 302H, Charleston, SC 29425 USA.
EM zapka@musc.edu
FU CCR NIH HHS [HHSN261200800001C]; Intramural NIH HHS [Z99 CA999999]; NCI
   NIH HHS [HHSN261200800001E]
NR 80
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U1 3
U2 10
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD OCT
PY 2014
VL 23
IS 10
BP 1965
EP 1973
DI 10.1158/1055-9965.EPI-14-0454
PG 9
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AT9XP
UT WOS:000345277400002
PM 25073625
ER

PT J
AU Moore, LL
   Chadid, S
   Singer, MR
   Kreger, BE
   Denis, GV
AF Moore, Lynn L.
   Chadid, Susan
   Singer, Martha R.
   Kreger, Bernard E.
   Denis, Gerald V.
TI Metabolic Health Reduces Risk of Obesity-Related Cancer in Framingham
   Study Adults
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID TO-HEIGHT RATIO; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; SCREENING
   TOOL; INSULIN; GLUCOSE; COHORT; BMI; METAANALYSIS; MECHANISMS
AB Background: It is unknown whether the risk for obesity-related cancers differs between metabolically unhealthy and healthy overweight/obese adults.
   Methods: Data on body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and random blood glucose in Framingham Heart Study adults (n = 3,763) ages 55 to 69 years were used to estimate risks of obesity-related cancers (n = 385), including postmenopausal breast, female reproductive, colon, liver, gallbladder, pancreas, and kidney cancers, as well as esophageal adenocarcinomas. Multivariable-adjusted Cox proportional hazards models were used to estimate risk for obesity-related cancers associated with body fat and metabolic health (as defined by glucose levels) among subjects in three risk groups (vs. referent group with normal weight/normal glucose): normal weight/elevated glucose, overweight/normal glucose, and overweight/elevated glucose.
   Results: Overweight adults [BMI >= 25 or WHtR >= 0.51 (men) and >= 0.57 (women)] with elevated glucose (>= 125 mg/dL) had a statistically significant 2-fold increased risk of developing obesity-related cancer, whereas overweight adults with normal glucose had a 50% increased risk. Normal-weight adults with elevated glucose had no excess cancer risk. The effects of BMI and WHtR were independent of one another. Finally, overweight women with elevated blood glucose had a 2.6-fold increased risk [95% confidence interval (CI), 1.4-4.9] of female reproductive (cervical, endometrial, uterine cancers) and postmenopausal breast cancers, whereas overweight women with normal glucose levels had only a 70% increased risk (95% CI, 1.1-2.5).
   Conclusion: These results suggest that cancer risk may be lower among metabolically healthy overweight/obese older adults than among overweight/obese adults with metabolic dysfunction.
   Impact: Metabolic dysfunction and obesity act synergistically to increase cancer risk. (C) 2014 AACR.
C1 [Moore, Lynn L.; Chadid, Susan; Singer, Martha R.; Kreger, Bernard E.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
   [Moore, Lynn L.; Kreger, Bernard E.] NHLBI, Framingham Heart Study, Framingham, MA USA.
   [Denis, Gerald V.] Boston Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02118 USA.
   [Denis, Gerald V.] Boston Univ, Sch Med, Canc Res Ctr, Boston, MA 02118 USA.
RP Moore, LL (reprint author), Boston Univ, Sch Med, 801 Massachusetts Ave,Suite 470, Boston, MA 02118 USA.
EM llmoore@bu.edu
OI Denis, Gerald/0000-0001-9886-0401
FU National Heart, Lung, and Blood Institute; Evans Center at Boston
   University; Boston University School of Medicine [N01-HC-25195]
FX Funding for the Framingham Heart Study is provided by the National
   Heart, Lung, and Blood Institute and Boston University School of
   Medicine (Contract No. N01-HC-25195). This analytic work was partially
   supported by grants from the Evans Center at Boston University (GVD).
NR 33
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PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD OCT
PY 2014
VL 23
IS 10
BP 2057
EP 2065
DI 10.1158/1055-9965.EPI-14-0240
PG 9
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AT9XP
UT WOS:000345277400012
PM 25012997
ER

PT J
AU Bethea, TN
   Kitahara, CM
   Sonderman, J
   Patel, AV
   Harvey, C
   Knutsen, SF
   Park, Y
   Park, SY
   Fraser, GE
   Jacobs, EJ
   Purdue, MP
   Stolzenberg-Solomon, RZ
   Gillanders, EM
   Blot, WJ
   Palmer, JR
   Kolonel, LN
AF Bethea, Traci N.
   Kitahara, Cari M.
   Sonderman, Jennifer
   Patel, Alpa V.
   Harvey, Chinonye
   Knutsen, Synnove F.
   Park, Yikyung
   Park, Song Yi
   Fraser, Gary E.
   Jacobs, Eric J.
   Purdue, Mark P.
   Stolzenberg-Solomon, Rachael Z.
   Gillanders, Elizabeth M.
   Blot, William J.
   Palmer, Julie R.
   Kolonel, Laurence N.
TI A Pooled Analysis of Body Mass Index and Pancreatic Cancer Mortality in
   African Americans
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID CONTROL CONSORTIUM PANC4; PHYSICAL-ACTIVITY; RACIAL DISPARITIES;
   CIGARETTE-SMOKING; COHORT-CONSORTIUM; RISK-FACTORS; US ADULTS; AARP
   DIET; OBESITY; HEALTH
AB Background: Pancreatic cancer is a leading cause of cancer-related mortality in the United States and both incidence and mortality are highest in African Americans. Obesity is also disproportionately high in African Americans, but limited data are available on the relation of obesity to pancreatic cancer in this population.
   Methods: Seven large prospective cohort studies pooled data from African American participants. Body mass index (BMI) was calculated from self-reported height and weight at baseline. Cox regression was used to calculate HRs and 95% confidence intervals (CI) for levels of BMI relative to BMI 18.5-24.9, with adjustment for covariates. Primary analyses were restricted to participants with >= 5 years of follow-up because weight loss before diagnosis may have influenced baseline BMI in cases who died during early follow-up.
   Results: In follow-up of 239,597 participants, 897 pancreatic cancer deaths occurred. HRs were 1.08 (95% CI, 0.90-1.31) for BMI 25.0 to 29.9, 1.25 (95% CI, 0.99-1.57) for BMI 30.0 to 34.9, and 1.31 (95% CI, 0.97-1.77) for BMI >= 35.0 among those with >= 5 years of follow-up (P-trend = 0.03). The association was evident among both sexes and was independent of a history of diabetes. Astronger association was observed among never-smokers (BMI >= 30 vs. referent: HR = 1.44; 95% CI, 1.02-2.03) than among smokers (HR = 1.16; 95% CI, 0.87-1.54; P-interaction = 0.02).
   Conclusion: The findings suggest that obesity is independently associated with increased pancreatic cancer mortality in African Americans.
   Impact: Interventions to reduce obesity may also reduce risk of pancreatic cancer mortality, particularly among never-smokers. (C) 2014 AACR.
C1 [Bethea, Traci N.; Palmer, Julie R.] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
   [Kitahara, Cari M.; Park, Yikyung; Purdue, Mark P.; Stolzenberg-Solomon, Rachael Z.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
   [Sonderman, Jennifer; Blot, William J.] Int Epidemiol Inst, Rockville, MD USA.
   [Patel, Alpa V.; Jacobs, Eric J.] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Harvey, Chinonye; Gillanders, Elizabeth M.] NCI, Epidemiol & Genom Res Program, Rockville, MD USA.
   [Knutsen, Synnove F.; Fraser, Gary E.] Loma Linda Univ, Loma Linda, CA 92350 USA.
   [Park, Song Yi; Kolonel, Laurence N.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
   [Blot, William J.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
RP Bethea, TN (reprint author), Boston Univ, Slone Epidemiol Ctr, 1010 Commonwealth Ave, Boston, MA 02215 USA.
EM tnb@bu.edu
RI Purdue, Mark/C-9228-2016; Kitahara, Cari/R-8267-2016; 
OI Purdue, Mark/0000-0003-1177-3108; Park, Yikyung/0000-0002-6281-489X
FU National Cancer Institute's Intramural Research Program in the Division
   of Cancer Epidemiology and Genetics; Epidemiology and Genomics Research
   Program in the Division of Cancer Control and Populations Sciences;
   National Cancer Institute [R01 CA94594, R01 CA058420, R37CA54281, R01
   CA092447, R01 CA092447-08S1]; American Cancer Society; Intramural
   Research Program of the National Cancer Institute; Epidemiology and
   Genomics Research Program in the National Cancer Institute's Division of
   Cancer Control and Population Sciences
FX This work was supported by the National Cancer Institute's Intramural
   Research Program in the Division of Cancer Epidemiology and Genetics and
   the Epidemiology and Genomics Research Program in the Division of Cancer
   Control and Populations Sciences. Funding to individual cohorts and
   investigators included grants from the National Cancer Institute: R01
   CA94594 (to G.E. Fraser and S.F. Knutsen), R01 CA058420 (to T.N. Bethea
   and J.R. Palmer), R37CA54281 (to L.N. Kolonel and S. Park), R01 CA092447
   (to W.J. Blot), R01 CA092447-08S1 (to W.J. Blot and J. Sonderman); the
   American Cancer Society (to E.J. Jacobs and A. Patel); the Intramural
   Research Program of the National Cancer Institute (to C. M. Kitahara, Y.
   Park, M.P. Purdue, and R.Z. Stolzenberg-Solomon); and Epidemiology and
   Genomics Research Program in the National Cancer Institute's Division of
   Cancer Control and Population Sciences (to E.M. Gillanders and C.
   Harvey).
NR 39
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U1 0
U2 8
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD OCT
PY 2014
VL 23
IS 10
BP 2119
EP 2125
DI 10.1158/1055-9965.EPI-14-0422
PG 7
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AT9XP
UT WOS:000345277400018
PM 25017247
ER

PT J
AU Jack, JR
   Motsinger-Reif, AA
   Koutros, S
   Alavanja, MC
   Freeman, LEB
   Hoppin, JA
AF Jack, John R.
   Motsinger-Reif, Alison A.
   Koutros, Stella
   Alavanja, Michael C.
   Freeman, Laura E. Beane
   Hoppin, Jane A.
TI Single-Nucleotide Polymorphism Data Support the General Unrelatedness of
   the Males in the Agricultural Health Study
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID PROSTATE-CANCER; PESTICIDE EXPOSURE; PATHWAY GENES; ASSOCIATION;
   VARIANTS
AB Background: Farming is often a family and multigenerational business. Relatedness among farmers could bias gene-environment interaction analysis. To evaluate the potential relatedness of farmers, we used data from a nested case-control study of prostate cancer conducted in the Agricultural Health Study (AHS), a prospective study of farmers in Iowa and North Carolina.
   Methods: We analyzed the genetic data for 25,009 SNPs (single-nucleotide polymorphisms) from 2,220 White participants to test for cryptic relatedness among these farmers. We used two software packages: (i) PLINK, to calculate inbreeding coefficients and identity-by-descent (IBD) statistics and (ii) EIGENSOFT, to perform a principal component analysis on the genetic data.
   Results: Inbreeding coefficients estimates and IBD statistics show that the subjects are overwhelmingly unrelated, with little potential for cryptic relatedness in these data.
   Conclusions: Our analysis rejects the hypothesis that individuals in the case-control study exhibit cryptic relatedness.
   Impact: These findings are important for all subsequent analyses of gene-environment interactions in the AHS. (C) 2014 AACR.
C1 [Jack, John R.; Motsinger-Reif, Alison A.] N Carolina State Univ, Bioinformat Res Ctr, Dept Stat, Ctr Human Hlth & Environm,Ctr Comparat Med & Tran, Raleigh, NC 27695 USA.
   [Koutros, Stella; Alavanja, Michael C.; Freeman, Laura E. Beane] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv,NIH, Bethesda, MD 20892 USA.
   [Hoppin, Jane A.] N Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA.
RP Jack, JR (reprint author), N Carolina State Univ, Bioinformat Res Ctr, Campus Box 7566,2601 Stinson Dr, Raleigh, NC 27695 USA.
EM jrjack@ncsu.edu
RI Beane Freeman, Laura/C-4468-2015
OI Beane Freeman, Laura/0000-0003-1294-4124
FU intramural research program of the NIH, National Cancer Institute
   [Z01-ES049030]; National Institute of Environmental Health Sciences
   [Z01-CP010119]; Pilot Project Program of the North Carolina State
   University's Center for Human Health and the Environment
FX This work was supported in part by the intramural research program of
   the NIH, National Cancer Institute (Z01-ES049030; PIs, M.C. Alavanja and
   I.,E. Beane Freeman), National Institute of Environmental Health
   Sciences (Z01-CP010119; PI, D. P. Sandler), and Pilot Project Program
   (PI, Alison Motsinger-Reif) of the North Carolina State University's
   Center for Human Health and the Environment.
NR 8
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U1 1
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD OCT
PY 2014
VL 23
IS 10
BP 2192
EP 2195
DI 10.1158/1055-9965.EPI-14-0276
PG 4
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AT9XP
UT WOS:000345277400027
PM 25047895
ER

PT J
AU Leggio, L
   Schwandt, ML
AF Leggio, Lorenzo
   Schwandt, Melanie L.
TI Topiramate for alcoholism treatment: novel pharmacogenetic evidence for
   the journey to personalized medicine?
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Editorial Material
DE Alcoholism; pharmacogenetics; topiramate
ID RANDOMIZED CONTROLLED-TRIAL; 5 IGLUR5 ANTAGONIST; NALTREXONE RESPONSE;
   CLINICAL-TRIALS; HEAVY DRINKERS; DEPENDENCE; ONDANSETRON; POLYMORPHISM;
   ACAMPROSATE; SERTRALINE
C1 [Leggio, Lorenzo] NIAAA, Sect Clin Psychoneuroendocrinol & Neuropsychophar, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA.
   [Leggio, Lorenzo] NIDA, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Leggio, Lorenzo] Brown Univ, Ctr Alcohol & Addict Studies, Dept Behav & Social Sci, Providence, RI 02912 USA.
   [Schwandt, Melanie L.] NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA.
RP Leggio, L (reprint author), NIAAA, Sect Clin Psychoneuroendocrinol & Neuropsychophar, NIH, 10 Ctr Dr 10CRC 15330 MSC 1108,Room 1-5429, Bethesda, MD 20892 USA.
EM lorenzo.leggio@nih.gov
RI Schwandt, Melanie/L-9866-2016; Leggio, Lorenzo/M-2972-2016
FU Intramural NIH HHS
NR 27
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U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD OCT
PY 2014
VL 17
IS 10
BP 1541
EP 1544
DI 10.1017/S1461145714000790
PG 4
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AT5TL
UT WOS:000345004900001
PM 24892413
ER

PT J
AU Goldman, D
   Domschke, K
AF Goldman, D.
   Domschke, K.
TI Making sense of deep sequencing
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE ChipSeq; exome; methylome; next-generation sequencing; RNASeq
ID AUTISM SPECTRUM DISORDERS; GENETIC-VARIATION; NOVO MUTATIONS;
   SCHIZOPHRENIA; GENOME
AB This review, the first of an occasional series, tries to make sense of the concepts and uses of deep sequencing of polynucleic acids (DNA and RNA). Deep sequencing, synonymous with next-generation sequencing, high-throughput sequencing and massively parallel sequencing, includes whole genome sequencing but is more often and diversely applied to specific parts of the genome captured in different ways, for example the highly expressed portion of the genome known as the exome and portions of the genome that are epigenetically marked either by DNA methylation, the binding of proteins including histones, or that are in different configurations and thus more or less accessible to enzymes that cleave DNA. Deep sequencing of RNA (RNASeq) reverse-transcribed to complementary DNA is invaluable for measuring RNA expression and detecting changes in RNA structure. Important concepts in deep sequencing include the length and depth of sequence reads, mapping and assembly of reads, sequencing error, haplotypes, and the propensity of deep sequencing, as with other types of 'big data', to generate large numbers of errors, requiring monitoring for methodologic biases and strategies for replication and validation. Deep sequencing yields a unique genetic fingerprint that can be used to identify a person, and a trove of predictors of genetic medical diseases. Deep sequencing to identify epigenetic events including changes in DNA methylation and RNA expression can reveal the history and impact of environmental exposures. Because of the power of sequencing to identify and deliver biomedically significant information about a person and their blood relatives, it creates ethical dilemmas and practical challenges in research and clinical care, for example the decision and procedures to report incidental findings that will increasingly and frequently be discovered.
C1 [Goldman, D.] NIAAA, Neurogenet Lab, NIH, Rockville, MD 20852 USA.
   [Domschke, K.] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany.
RP Domschke, K (reprint author), Univ Wurzburg, Dept Psychiat, Fuechsleinstr 15, D-97080 Wurzburg, Germany.
EM Domschke_K@ukw.de
RI Goldman, David/F-9772-2010
OI Goldman, David/0000-0002-1724-5405
FU Deutsche Forschungsgemeinschaft (DFG) [SFB-TRR-58]
FX The present work was supported by the Deutsche Forschungsgemeinschaft
   (DFG), SFB-TRR-58, project C02 (to KD).
NR 20
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U1 7
U2 36
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD OCT
PY 2014
VL 17
IS 10
BP 1717
EP 1725
DI 10.1017/S1461145714000789
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AT5TL
UT WOS:000345004900019
PM 24925306
ER

PT J
AU Teng, JMC
   Cowen, EW
   Wataya-Kaneda, M
   Gosnell, ES
   Witman, PM
   Hebert, AA
   Mlynarczyk, G
   Soltani, K
   Darling, TN
AF Teng, Joyce M. C.
   Cowen, Edward W.
   Wataya-Kaneda, Mari
   Gosnell, Elizabeth S.
   Witman, Patricia M.
   Hebert, Adelaide A.
   Mlynarczyk, Greg
   Soltani, Keyoumars
   Darling, Thomas N.
TI Dermatologic and Dental Aspects of the 2012 International Tuberous
   Sclerosis Complex Consensus Statements
SO JAMA DERMATOLOGY
LA English
DT Article
ID HOGG-DUBE-SYNDROME; PULSED DYE-LASER; MULTIPLE FACIAL ANGIOFIBROMAS;
   DIAGNOSTIC-CRITERIA; GINGIVAL OVERGROWTH; PEDIATRIC-PATIENTS; TOPICAL
   RAPAMYCIN; MTOR INHIBITORS; RECOMMENDATIONS; PREVALENCE
AB IMPORTANCE The 2012 International Tuberous Sclerosis Complex Clinical Consensus Conference was convened to update the last consensus statement in 1998. Skin and dental lesions are common in tuberous sclerosis complex (TSC) and are a frequent concern for patients. Recognition of these lesions is imperative for early diagnosis, given the treatment advances that may improve patient outcomes.
   OBJECTIVE To detail recommendations for the diagnosis, surveillance, and management of skin and dental lesions in TSC.
   EVIDENCE REVIEW The TSC Dermatology and Dentistry Subcommittee, 1 of 12 subcommittees, reviewed the relevant literature from 1997 to 2012.
   FINDINGS A consensus on skin and dental issues was achieved within the Dermatology and Dentistry Subcommittee before recommendations were presented, discussed, and agreed on in a group meeting of all subcommittees from June 14 to 15, 2012.
   CONCLUSIONS AND RELEVANCE Skin and dental findings comprise 4 of 11 major features and 3 of 6 minor features in the diagnostic criteria. A definite diagnosis of TSC is defined as the presence of at least 2 major features or 1 major and 2 or more minor features; in addition, a pathological mutation in TSC1 or TSC2 is diagnostic. Skin and oral examinations should be performed annually and every 3 to 6 months, respectively. Intervention may be indicated for TSC skin or oral lesions that are bleeding, symptomatic, disfiguring, or negatively affecting function. Options presented include surgical excision, laser(s), or use of a mammalian target of rapamycin inhibitor.
C1 [Teng, Joyce M. C.] Stanford Univ, Dept Dermatol, Sch Med, Stanford, CA 94305 USA.
   [Cowen, Edward W.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA.
   [Wataya-Kaneda, Mari] Osaka Univ, Grad Sch Med, Dept Dermatol, Osaka, Japan.
   [Gosnell, Elizabeth S.] Cincinnati Childrens Hosp, Div Pediat Dent & Orthodont, Cincinnati, OH USA.
   [Witman, Patricia M.] Nationwide Childerns Hosp, Dept Pediat, Div Dermatol, Columbus, OH USA.
   [Witman, Patricia M.] Ohio State Univ, Columbus, OH 43210 USA.
   [Hebert, Adelaide A.] Univ Texas Houston, Sch Med, Dept Dermatol, Houston, TX USA.
   [Hebert, Adelaide A.] Univ Texas Houston, Sch Med, Dept Pediat, Houston, TX USA.
   [Mlynarczyk, Greg] Santa Rosa Family & Cosmet Dent, Santa Rosa, CA USA.
   [Soltani, Keyoumars] Univ Chicago, Dept Med, Dermatol Sect, Chicago, IL 60637 USA.
   [Darling, Thomas N.] Uniformed Serv Univ Hlth Sci, Dept Dermatol, Bethesda, MD 20814 USA.
RP Darling, TN (reprint author), Uniformed Serv Univ Hlth Sci, Dept Dermatol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM thomas.darling@usuhs.edu
OI Darling, Thomas/0000-0002-5161-1974
FU Tuberous Sclerosis Alliance; Rothberg Institute for Childhood Diseases;
   Novartis Pharmaceuticals; Sandra and Brian O'Brien; Questcor
   Pharmaceuticals; Intramural Research Program, National Institutes of
   Health, National Heart, Lung, and Blood Institute
FX The 2012 International TSC Clinical Consensus Conference was sponsored
   and organized by the Tuberous Sclerosis Alliance. The conference was
   supported in part by the Rothberg Institute for Childhood Diseases,
   Novartis Pharmaceuticals, Sandra and Brian O'Brien, and Questcor
   Pharmaceuticals. Photography was obtained with support of the Intramural
   Research Program, National Institutes of Health, National Heart, Lung,
   and Blood Institute.
NR 51
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PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6068
EI 2168-6084
J9 JAMA DERMATOL
JI JAMA Dermatol.
PD OCT
PY 2014
VL 150
IS 10
BP 1095
EP 1101
DI 10.1001/jamadermatol.2014.938
PG 7
WC Dermatology
SC Dermatology
GA AT9WH
UT WOS:000345274000013
PM 25029267
ER

PT J
AU Lahiri, S
   Chao, JT
   Tavassoli, S
   Wong, AKO
   Choudhary, V
   Young, BP
   Loewen, CJR
   Prinz, WA
AF Lahiri, Sujoy
   Chao, Jesse T.
   Tavassoli, Shabnam
   Wong, Andrew K. O.
   Choudhary, Vineet
   Young, Barry P.
   Loewen, Christopher J. R.
   Prinz, William A.
TI A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC)
   Facilitates Phospholipid Transfer from the ER to Mitochondria
SO PLOS BIOLOGY
LA English
DT Article
ID YEAST SACCHAROMYCES-CEREVISIAE; ORGANELLE CONTACT SITES;
   PHOSPHATIDYLSERINE DECARBOXYLASE; LIPID TRANSFER; NULL ALLELE; GENE;
   BIOGENESIS; METABOLISM; TRANSPORT; CLONING
AB Mitochondrial membrane biogenesis and lipid metabolism require phospholipid transfer from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions of close contact of these organelles and to be nonvesicular, but the mechanism is not known. Here we used a novel genetic screen in S. cerevisiae to identify mutants with defects in lipid exchange between the ER and mitochondria. We show that a strain missing multiple components of the conserved ER membrane protein complex (EMC) has decreased phosphatidylserine (PS) transfer from the ER to mitochondria. Mitochondria from this strain have significantly reduced levels of PS and its derivative phosphatidylethanolamine (PE). Cells lacking EMC proteins and the ER-mitochondria tethering complex called ERMES (the ER-mitochondria encounter structure) are inviable, suggesting that the EMC also functions as a tether. These defects are corrected by expression of an engineered ER-mitochondrial tethering protein that artificially tethers the ER to mitochondria. EMC mutants have a significant reduction in the amount of ER tethered to mitochondria even though ERMES remained intact in these mutants, suggesting that the EMC performs an additional tethering function to ERMES. We find that all Emc proteins interact with the mitochondrial translocase of the outer membrane (TOM) complex protein Tom5 and this interaction is important for PS transfer and cell growth, suggesting that the EMC forms a tether by associating with the TOM complex. Together, our findings support that the EMC tethers ER to mitochondria, which is required for phospholipid synthesis and cell growth.
C1 [Lahiri, Sujoy; Choudhary, Vineet; Prinz, William A.] NIDDKD, NIH, Lab Cell & Mol Biol, Bethesda, MD 20892 USA.
   [Chao, Jesse T.; Tavassoli, Shabnam; Wong, Andrew K. O.; Young, Barry P.; Loewen, Christopher J. R.] Univ British Columbia, Dept Cellular & Physiol Sci, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada.
RP Lahiri, S (reprint author), NIDDKD, NIH, Lab Cell & Mol Biol, Bethesda, MD 20892 USA.
EM christopher.loewen@ubc.ca; prinzw@helix.nih.gov
FU Intramural Research Program of the National Institute of Diabetes and
   Digestive and Kidney Diseases; Canadian Institutes of Health Research;
   Natural Sciences and Engineering Research Council of Canada; Michael
   Smith Foundation for Health Research; Canada Foundation for Innovation;
   Tula Foundation
FX S.L., V. C., and W. A. P. were supported by the Intramural Research
   Program of the National Institute of Diabetes and Digestive and Kidney
   Diseases (http://irp.nih.gov/our-research/our-programs/niddk). C. L. was
   supported by the Canadian Institutes of Health Research
   (http://www.cihr-irsc.gc.ca/e/193.html), the Natural Sciences and
   Engineering Research Council of Canada
   (http://www.nserc-crsng.gc.ca/index_eng.asp), the Michael Smith
   Foundation for Health Research (http://www.msfhr.org), the Canada
   Foundation for Innovation (http://www.innovation.ca), and the Tula
   Foundation (http://tula.org). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 55
TC 61
Z9 61
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1545-7885
J9 PLOS BIOL
JI PLoS. Biol.
PD OCT
PY 2014
VL 12
IS 10
AR e1001969
DI 10.1371/journal.pbio.1001969
PG 18
WC Biochemistry & Molecular Biology; Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA AS7WD
UT WOS:000344461700008
PM 25313861
ER

PT J
AU Rastegar, N
   Burt, JR
   Corona-Villalobos, CP
   te Riele, AS
   James, CA
   Murray, B
   Calkins, H
   Tandri, H
   Bluemke, DA
   Zimmerman, SL
   Kamel, IR
AF Rastegar, Neda
   Burt, Jeremy R.
   Corona-Villalobos, Celia P.
   te Riele, Anneline S.
   James, Cynthia A.
   Murray, Brittney
   Calkins, Hugh
   Tandri, Harikrishna
   Bluemke, David A.
   Zimmerman, Stefan L.
   Kamel, Ihab R.
TI Cardiac MR Findings and Potential Diagnostic Pitfalls in Patients
   Evaluated for Arrhythmogenic Right Ventricular Cardiomyopathy
SO RADIOGRAPHICS
LA English
DT Article
ID TASK-FORCE CRITERIA; FATTY INFILTRATION; IMAGING FINDINGS; MYOCARDIAL
   FAT; YOUNG-PEOPLE; NORMAL HEART; DYSPLASIA; DYSPLASIA/CARDIOMYOPATHY;
   SARCOIDOSIS; PREVALENCE
AB Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiomyopathy characterized by fibrofatty replacement of the myocardium, ventricular tachycardia, and ventricular dysfunction that affects primarily the right ventricle (RV). This disease is not common but can be seen more frequently in young adults, and clinical manifestations range from no symptoms to lethal arrhythmia and sudden death. The diagnosis of ARVC is challenging and is based on the recently revised international task force criteria. Given the strengths of cardiac magnetic resonance (MR) imaging for depicting the RV, this modality plays an important role in the diagnosis of ARVC. Functional and structural abnormalities of the RV depicted with cardiac MR imaging constitute major and minor criteria in the revised task force criteria. Since the ARVC program was established at our center in 1998, there has been an increased awareness of a number of normal variants that are commonly misinterpreted as showing evidence for ARVC. On the basis of our clinical experience, the overdiagnosis of ARVC appears to reflect two fundamental problems: (a) a lack of awareness of diagnostic criteria that identify major and minor variables to be used for the diagnosis of ARVC, and (b) a lack of familiarity with the normal variants and mimics that may be misinterpreted as showing evidence of ARVC. The purpose of this article is to review the typical patterns of ventricular involvement in ARVC at cardiac MR imaging and to compare those with the patterns of normal variants and other diseases that can mimic ARVC. Online supplemental material is available for this article. (C) RSNA, 2014 . radiographics.rsna.org
C1 [Rastegar, Neda; Burt, Jeremy R.; Corona-Villalobos, Celia P.; Zimmerman, Stefan L.; Kamel, Ihab R.] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA.
   [James, Cynthia A.; Murray, Brittney; Calkins, Hugh; Tandri, Harikrishna] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD 21287 USA.
   [te Riele, Anneline S.] Univ Med Ctr Utrecht, Div Cardiol, Utrecht, Netherlands.
   [Bluemke, David A.] NIH, Ctr Clin, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA.
RP Kamel, IR (reprint author), Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St,MRI 143, Baltimore, MD 21287 USA.
EM ikamel@jhmi.edu
OI Bluemke, David/0000-0002-8323-8086
FU Bogle Foundation; Healing Hearts Foundation; Campanella family;
   Wilmerding Endowments; Dr. Francis P. Chiaramonte Private Foundation
FX The Johns Hopkins ARVD/C Program is supported in part by the Bogle
   Foundation, the Healing Hearts Foundation, the Campanella family, the
   Wilmerding Endowments, and the Dr. Francis P. Chiaramonte Private
   Foundation.
NR 52
TC 8
Z9 8
U1 0
U2 2
PU RADIOLOGICAL SOC NORTH AMERICA
PI OAK BROOK
PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA
SN 0271-5333
J9 RADIOGRAPHICS
JI Radiographics
PD OCT
PY 2014
VL 34
IS 6
BP 1553
EP 1570
DI 10.1148/rg.346140194
PG 18
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AT5SC
UT WOS:000345001100008
PM 25310417
ER

PT J
AU Ogilvy, AJ
   Shen, DF
   Wang, YJ
   Chan, CC
   Abu-Asab, MS
AF Ogilvy, Alexander J.
   Shen, Defen
   Wang, Yujuan
   Chan, Chi-Chao
   Abu-Asab, Mones S.
TI Implications of DNA Leakage in Eyes of Mutant Mice
SO ULTRASTRUCTURAL PATHOLOGY
LA English
DT Article
DE Autophagy; enDNA; extranuclear DNA; hypoxia; mitochondria; retinal
   pigment epithelium; RPE; vastus medialis
ID MACULAR DEGENERATION; CIRCULAR DNA; HYPOXIA; MITOCHONDRIA; AUTOPHAGY;
   DAMAGE; CELLS
AB Extranuclear DNA (enDNA) is not well studied ultrastructurally in the retinal pigment epithelium (RPE). We analyzed the retina and vastus medialis muscle of four mouse strains that are related to focal retinal degeneration by transmission electron microscopy (TEM) and EM immunolabeling. Evaluation of enDNA would imply the involvements of enDNA is either limited to the affected tissue or generalized in the whole body. Ultrastructural analysis and EM immunolabeling revealed that enDNA was present in the RPE cells but not in the muscle. These data suggest that enDNA could be unique to unhealthy RPE and a potential biomarker for cellular abnormality.
C1 [Ogilvy, Alexander J.; Shen, Defen; Chan, Chi-Chao; Abu-Asab, Mones S.] NEI, Immunol Lab, Bethesda, MD 20892 USA.
   [Wang, Yujuan] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China.
RP Abu-Asab, MS (reprint author), NEI, Immunopathol Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM mones@mail.nih.gov
RI wang, yujuan/C-8428-2016
FU Intramural NIH HHS [Z99 EY999999, ZIA EY000418-10, ZIA EY000418-11, ZIC
   EY000461-06, ZIC EY000461-07]
NR 20
TC 2
Z9 2
U1 0
U2 2
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0191-3123
J9 ULTRASTRUCT PATHOL
JI Ultrastruct. Pathol.
PD OCT
PY 2014
VL 38
IS 5
BP 335
EP 343
DI 10.3109/01913123.2014.927406
PG 9
WC Microscopy; Pathology
SC Microscopy; Pathology
GA AU0YR
UT WOS:000345348700006
PM 24963552
ER

PT J
AU Zhang, TF
   Tang, XG
   Liu, QX
   Lu, SG
   Jiang, YP
   Huang, XX
   Zhou, QF
AF Zhang, Tian-Fu
   Tang, Xin-Gui
   Liu, Qiu-Xiang
   Lu, Sheng-Guo
   Jiang, Yan-Ping
   Huang, Xian-Xiong
   Zhou, Qi-Fa
TI Oxygen-vacancy-related relaxation and conduction behavior in
   (Pb1-xBax)(Zr0.95Ti0.05)O-3 ceramics
SO AIP ADVANCES
LA English
DT Article
ID THIN-FILMS; DIELECTRIC-RELAXATION; ELECTRICAL-PROPERTIES; SPECTROSCOPIC
   ELLIPSOMETRY; PIEZOELECTRIC PROPERTIES; PHASE-TRANSFORMATION;
   OPTICAL-PROPERTIES; FIELD; POROSITY; TEMPERATURES
AB (Pb1-xBax)(Zr0.95Ti0.05)O-3 (x=0, 0.025, 0.05, 0.075 and 0.1) ceramics were prepared via a solid-state reaction route. Low-frequency (20 similar to 2x10(7) Hz) dielectric properties were investigated in the temperature region of 25-650 degrees C. Ba2+ doping can slightly reduce the phase transition temperature of ferroelectric to paraelectric. The dielectric diffuse anomaly in the dielectric relaxation was found in the high temperature region of 400-650 degrees C. Activation energy, calculated from the impedance and conductivity data of samples, suggests that the dielectric relaxation is due to oxygen vacancies generated during the sintering process. Ba2+ doping can reduce significantly the concentration of oxygen vacancies, and slightly enhance activation energy for the migration of oxygen vacancies. Results of activation energy calculated from impedance and conductance suggest that the dielectric relaxation is due to the short-range hopping of oxygen vacancies, and the conduction due to the movement of doubly-ionized oxygen vacancies. (C) 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.
C1 [Zhang, Tian-Fu; Tang, Xin-Gui; Liu, Qiu-Xiang; Jiang, Yan-Ping; Huang, Xian-Xiong] Guangdong Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Phys & Optoelect Engn, Guangzhou 510006, Guangdong, Peoples R China.
   [Lu, Sheng-Guo] Guangdong Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Mat & Energy, Guangzhou 510006, Guangdong, Peoples R China.
   [Zhou, Qi-Fa] Univ So Calif, NIH Transducer Resource Ctr, Los Angeles, CA 90089 USA.
   [Zhou, Qi-Fa] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA.
RP Tang, XG (reprint author), Guangdong Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Phys & Optoelect Engn, Guangzhou 510006, Guangdong, Peoples R China.
EM xgtang@gdut.edu.cn
FU National Natural Science Foundation of China [10774030, 11032010,
   11202054]; Guangdong Provincial Natural Science Foundation of China
   [8151009001000003, 10151009001000050]; Guangdong Provincial Educational
   Commission of China [2012KJCX0044]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 10774030, 11032010, and 11202054), the Guangdong
   Provincial Natural Science Foundation of China (Grant Nos.
   8151009001000003 and 10151009001000050) and the Guangdong Provincial
   Educational Commission of China (Grant No. 2012KJCX0044).
NR 50
TC 5
Z9 5
U1 5
U2 33
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 2158-3226
J9 AIP ADV
JI AIP Adv.
PD OCT
PY 2014
VL 4
IS 10
AR 107141
DI 10.1063/1.4900610
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
   Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA AS9WB
UT WOS:000344588200042
ER

PT J
AU Thrift, AP
   Cook, MB
   Vaughan, TL
   Anderson, LA
   Murray, LJ
   Whiteman, DC
   Shaheen, NJ
   Corley, DA
AF Thrift, Aaron P.
   Cook, Michael B.
   Vaughan, Thomas L.
   Anderson, Lesley A.
   Murray, Liam J.
   Whiteman, David C.
   Shaheen, Nicholas J.
   Corley, Douglas A.
TI Alcohol and the Risk of Barrett's Esophagus: A Pooled Analysis from the
   International BEACON Consortium
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
ID BODY-MASS INDEX; GASTROESOPHAGEAL-REFLUX; SMOKING INCREASES;
   ADENOCARCINOMA; CANCER; SURVEILLANCE; PREDICTION; MORTALITY; SYMPTOMS;
   COHORT
AB OBJECTIVES: Results from studies examining the association between alcohol consumption and the risk of Barrett's esophagus have been inconsistent. We assessed the risk of Barrett's esophagus associated with total and beverage-specific alcohol consumption by pooling individual participant data from five case-control studies participating in the international Barrett's and Esophageal Adenocarcinoma Consortium.
   METHODS: For analysis, there were 1,282 population-based controls, 1,418 controls with gastroesophageal reflux disease (GERD), and 1,169 patients with Barrett's esophagus (cases). We estimated studyspecific odds ratios (ORs) and 95% confidence intervals (95% CI) using multivariable logistic regression models adjusted for age, sex, body mass index (BMI), education, smoking status, and GERD symptoms. Summary risk estimates were obtained by random-effects models. We also examined potential effect modification by sex, BMI, GERD symptoms, and cigarette smoking.
   RESULTS: For comparisons with population-based controls, although there was a borderline statistically significant inverse association between any alcohol consumption and the risk of Barrett's esophagus (any vs. none, summary OR = 0.77, 95% CI = 0.60-1.00), risk did not decrease in a dose-response manner (P-trend = 0.72). Among alcohol types, wine was associated with a moderately reduced risk of Barrett's esophagus (any vs. none, OR = 0.71, 95% CI = 0.52-0.98); however, there was no consistent dose-response relationship (P-trend = 0.21). We found no association with alcohol consumption when cases were compared with GERD controls. Similar associations were observed across all strata of BMI, GERD symptoms, and cigarette smoking.
   CONCLUSIONS: Consistent with findings for esophageal adenocarcinoma, we found no evidence that alcohol consumption increases the risk of Barrett's esophagus.
C1 [Thrift, Aaron P.] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA.
   [Thrift, Aaron P.; Whiteman, David C.] QIMR Berghofer Med Res Inst, Canc Control Grp, Brisbane, Qld, Australia.
   [Cook, Michael B.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Anderson, Lesley A.; Murray, Liam J.] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
   [Shaheen, Nicholas J.] Univ N Carolina, Sch Med, Div Gastroenterol & Hepatol, Chapel Hill, NC USA.
   [Corley, Douglas A.] Kaiser Permanente, Div Res, Oakland, CA USA.
   [Corley, Douglas A.] Kaiser Permanente, Oakland Med Ctr, Oakland, CA USA.
RP Thrift, AP (reprint author), Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, POB 19024,M4-B874, Seattle, WA 98104 USA.
EM athrift@fhcrc.org
RI Cook, Michael/A-5641-2009; Whiteman, David/P-2728-2014; 
OI Cook, Michael/0000-0002-0533-7302; Whiteman, David/0000-0003-2563-9559;
   Anderson, Lesley/0000-0002-1000-3649
FU National Institutes of Health [RO1 DK63616, 1R21DK077742, K23DK59311,
   R03DK75842]; Intramural Program of the National Institutes of Health;
   Ireland Northern Ireland cooperation research project grant - Northern
   Ireland Research and Development Office and the Health Research Board,
   Ireland (FINBAR) [RES/1699/01N/S]; Study of Digestive Health [NCI RO1 CA
   001833]; Study of Reflux Disease [NCI R01 CA72866]; Established
   Investigator Award in Cancer Prevention and Control [K05 CA124911]
FX This work was supported by the National Institutes of Health RO1 DK63616
   (D. A. C.); 1R21DK077742 (N.J.S. and D. A. C.); K23DK59311 and
   R03DK75842 (N.J.S.); the Intramural Program of the National Institutes
   of Health (M. B. C.); an Ireland Northern Ireland cooperation research
   project grant sponsored by the Northern Ireland Research and Development
   Office and the Health Research Board, Ireland (FINBAR; L.J.M.:
   RES/1699/01N/S); the Study of Digestive Health, NCI RO1 CA 001833 (D. C.
   W.); the Study of Reflux Disease, NCI R01 CA72866 (T. L. V.); and the
   Established Investigator Award in Cancer Prevention and Control, K05
   CA124911 (T. L. V.).
NR 31
TC 12
Z9 12
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2014
VL 109
IS 10
BP 1586
EP 1594
DI 10.1038/ajg.2014.206
PG 9
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AS7UM
UT WOS:000344460100014
PM 25047401
ER

PT J
AU Amaratunga, C
   Sreng, S
   Mao, S
   Tullo, GS
   Anderson, JM
   Chuor, CM
   Suon, S
   Fairhurst, RM
AF Amaratunga, Chanaki
   Sreng, Sokunthea
   Mao, Sivanna
   Tullo, Gregory S.
   Anderson, Jennifer M.
   Chuor, Char Meng
   Suon, Seila
   Fairhurst, Rick M.
TI Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in
   Pursat Province, Western Cambodia
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID DIHYDROARTEMISININ-PIPERAQUINE; FALCIPARUM; RESISTANCE
AB Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient but may promote the emergence and worsening of ART resistance in sympatric Plasmodium falciparum populations. Here, we show that CQ effectively treats P. vivax malaria in Pursat Province, western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.
C1 [Amaratunga, Chanaki; Tullo, Gregory S.; Anderson, Jennifer M.; Fairhurst, Rick M.] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA.
   [Sreng, Sokunthea; Chuor, Char Meng; Suon, Seila] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
   [Mao, Sivanna] Sampov Meas Referral Hosp, Pursat, Cambodia.
RP Fairhurst, RM (reprint author), NIAID, Lab Malaria & Vector Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM rfairhurst@niaid.nih.gov
FU NIAID, NIH
FX This work was funded by the Intramural Research Program of the NIAID,
   NIH.
NR 17
TC 4
Z9 4
U1 1
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2014
VL 58
IS 10
BP 6270
EP 6272
DI 10.1128/AAC.03026-14
PG 3
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AS3DT
UT WOS:000344157500077
PM 25049249
ER

PT J
AU Di Meo, A
   Diamandis, EP
   Rodriguez, H
   Hoofnagle, AN
   Ioannidis, J
   Lopez, M
AF Di Meo, Ashley
   Diamandis, Eleftherios P.
   Rodriguez, Henry
   Hoofnagle, Andrew N.
   Ioannidis, John
   Lopez, Mary
TI What Is Wrong with Clinical Proteomics?
SO CLINICAL CHEMISTRY
LA English
DT Editorial Material
C1 [Di Meo, Ashley] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Diamandis, Eleftherios P.] Univ Toronto, Dept Lab Med & Pathobiol, Div Clin Biochem, Toronto, ON, Canada.
   [Diamandis, Eleftherios P.] Mt Sinai Hosp, Dept Pathol & Lab Med, Clin Biochem Sect, Toronto, ON M5G 1X5, Canada.
   [Diamandis, Eleftherios P.] Univ Hlth Network, Dept Clin Biochem, Toronto, ON, Canada.
   [Rodriguez, Henry] NCI, Ctr Strateg Sci Initiat, Off Director, Off Canc Clin Prote Res, Bethesda, MD 20892 USA.
   [Hoofnagle, Andrew N.] Univ Washington, Div Clin Chem, Seattle, WA 98195 USA.
   [Hoofnagle, Andrew N.] Univ Washington, Nutr & Obes Res Ctr, Seattle, WA 98195 USA.
   [Ioannidis, John] Stanford Univ, Stanford Prevent Res Ctr, Sch Med, Stanford, CA 94305 USA.
   [Lopez, Mary] Thermo Fisher Sci, BRIMS Ctr, Cambridge, MA USA.
RP Diamandis, EP (reprint author), Mt Sinai Hosp, Dept Pathol & Lab Med, 6th Floor,Rm 6-201,Box 32,60 Murray St, Toronto, ON M5T 3L9, Canada.
EM ediamandis@mtsinai.on.ca
FU Waters; Thermo
FX A.N. Hoofnagle, institutional funding from Waters to the University of
   Washington and institutional funding from Thermo to the University of
   Washington.
NR 0
TC 6
Z9 6
U1 2
U2 8
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD OCT
PY 2014
VL 60
IS 10
BP 1258
EP 1266
DI 10.1373/clinchem.2014.225185
PG 9
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA AT2QR
UT WOS:000344779700004
PM 24831563
ER

PT J
AU Sacks, DB
AF Sacks, David B.
TI Commentary
SO CLINICAL CHEMISTRY
LA English
DT Editorial Material
C1 [Sacks, David B.] NIH, Dept Lab Med, Bethesda, MD 20892 USA.
RP Sacks, DB (reprint author), Dept Lab Med, Bldg 10,Rm 2C306,10 Ctr Dr, Bethesda, MD 20892 USA.
EM sacksdb@mail.nih.gov
OI Sacks, David/0000-0003-3100-0735
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD OCT
PY 2014
VL 60
IS 10
BP 1271
EP 1272
DI 10.1373/clinchem.2014.221408
PG 2
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA AT2QR
UT WOS:000344779700007
PM 25267514
ER

PT J
AU Butz, H
   Szabo, PM
   Nofech-Mozes, R
   Rotondo, F
   Kovacs, K
   Mirham, L
   Girgis, H
   Boles, D
   Patocs, A
   Yousef, GM
AF Butz, Henriett
   Szabo, Peter M.
   Nofech-Mozes, Roy
   Rotondo, Fabio
   Kovacs, Kalman
   Mirham, Lorna
   Girgis, Hala
   Boles, Dina
   Patocs, Attila
   Yousef, George M.
TI Integrative Bioinformatics Analysis Reveals New Prognostic Biomarkers of
   Clear Cell Renal Cell Carcinoma
SO CLINICAL CHEMISTRY
LA English
DT Article
ID ARYL-HYDROCARBON RECEPTOR; MICRORNA EXPRESSION; DOWN-REGULATION; CANCER;
   DIFFERENTIATION; ACTIVATION; TRANSITION; APOPTOSIS; DISEASE; TUMORS
AB BACKGROUND: The outcome of clear cell renal cell carcinoma (ccRCC) is still unpredictable. Even with new targeted therapies, the average progression-free survival is dismal. Markers for early detection and progression could improve disease outcome.
   METHODS: To identify efficient and hitherto unrecognized pathogenic factors of the disease, we performed a uniquely comprehensive pathway analysis and built a gene interaction network based on large publicly available data sets assembled from 28 publications, comprising a 3-prong approach with high-throughput mRNA, microRNA, and protein expression profiles of 593 ccRCC and 389 normal kidney samples. We validated our results on 2 different data sets of 882 ccRCC and 152 normal tissues. Functional analyses were done by proliferation, migration, and invasion assays following siRNA (small interfering RNA) knockdown.
   RESULTS: After integration of multilevel data, we identified aryl-hydrocarbon receptor (AHR), grainyheadlike-2 (GRHL2), and KIAA0101 as new pathogenic factors. GRHL2 expression was associated with higher chances for disease relapse and retained prognostic utility after controlling for grade and stage [hazard ratio (HR), 3.47, P = 0.012]. Patients with KIAA0101-positive expression suffered worse disease-free survival (HR, 3.64, P < 0.001), and in multivariate analysis KIAA0101 retained its independent prognostic significance. Survival analysis showed that GRHL2-and KIAA0101-positive patients had significantly lower disease-free survival (P = 0.002 and P < 0.001). We also found that KIAA0101 silencing decreased kidney cancer cell migration and invasion in vitro.
   CONCLUSIONS: Using an integrative system biology approach, we identified 3 novel factors as potential biomarkers (AHR, GRHL2 and KIAA0101) involved in ccRCC pathogenesis and not linked to kidney cancer before. (C) 2014 American Association for Clinical Chemistry
C1 [Butz, Henriett; Nofech-Mozes, Roy; Rotondo, Fabio; Kovacs, Kalman; Mirham, Lorna; Girgis, Hala; Boles, Dina; Yousef, George M.] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada.
   [Butz, Henriett; Nofech-Mozes, Roy; Rotondo, Fabio; Kovacs, Kalman; Mirham, Lorna; Girgis, Hala; Boles, Dina; Yousef, George M.] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada.
   [Butz, Henriett; Yousef, George M.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Szabo, Peter M.] NCI, Biometr Res Branch, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
   [Patocs, Attila] Hungarian Acad Sci, HAS SE Lendulet Hereditary Endocrine Tumors Res G, Budapest, Hungary.
RP Yousef, GM (reprint author), St Michaels Hosp, Dept Lab Med, 30 Bond St, Toronto, ON M5B 1W8, Canada.
EM yousefg@smh.ca
FU Canadian Institute of Health Research [MOP 119606]; Kidney Foundation of
   Canada [KFOC130030]; Kidney Cancer Research Network of Canada; Prostate
   Cancer Canada Movember Discovery Grants [D2013-39]
FX G.M. Yousef, grants from Canadian Institute of Health Research (MOP
   119606), Kidney Foundation of Canada (KFOC130030), the Kidney Cancer
   Research Network of Canada, and Prostate Cancer Canada Movember
   Discovery Grants (D2013-39).
NR 41
TC 12
Z9 12
U1 1
U2 12
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD OCT
PY 2014
VL 60
IS 10
BP 1314
EP 1326
DI 10.1373/clinchem.2014.225854
PG 13
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA AT2QR
UT WOS:000344779700015
PM 25139457
ER

PT J
AU Pardini, M
   Krueger, F
   Hodgkinson, CA
   Raymont, V
   Strenziok, M
   Amore, M
   Wassermann, EM
   Goldman, D
   Grafman, JH
AF Pardini, Matteo
   Krueger, Frank
   Hodgkinson, Colin A.
   Raymont, Vanessa
   Strenziok, Maren
   Amore, Mario
   Wassermann, Eric M.
   Goldman, David
   Grafman, Jordan H.
TI Aggression, DRD1 polymorphism, and lesion location in penetrating
   traumatic brain injury
SO CNS SPECTRUMS
LA English
DT Article
DE Aggression; behavioral neurology; dopamine; prefrontal cortex; traumatic
   brain injury
ID NUCLEUS-ACCUMBENS DOPAMINE; PREFRONTAL CORTEX; FRONTOTEMPORAL DEMENTIA;
   REWARD ANTICIPATION; MALE-MICE; BEHAVIOR; RISPERIDONE; SINGLE;
   STIMULATION; HALOPERIDOL
AB Objective. This study evaluated whether structural brain lesions modulate the relationship between pathological aggression and the dopaminergic system in traumatic brain injury (TBI). While converging evidence suggests that different areas of the prefrontal cortex modulate dopaminergic activity, to date no evidence exists of a modulation of endogenous dopaminergic tone by lesion localization in penetrating TBI (pTBI).
   Methods. This study included 141 male Caucasian veterans who suffered penetrating pTBI during their service in Vietnam and 29 healthy male Caucasian Vietnam veterans. Participants were genotyped for 3 functional single nucleotide polymorphisms (SNPs): dopamine receptor D1 (DRD1) rs686, dopamine receptor D2 (DRD2) rs4648317, and catechol-O-methyltransferase (COMT) Val158Met. Patients underwent brain CT scans and were divided into medial prefrontal cortex, lateral prefrontal cortex, and posterior cortex lesion groups. Long-term aggression levels were evaluated with the agitation/aggression subscale of the Neuropsychiatric Inventory.
   Results. Our data showed that carriers of more transcriptionally active DRD1 alleles compared to noncarriers demonstrated greater aggression levels due to medial prefrontal cortex lesions but reduced aggression levels due to lateral prefrontal cortex lesions independently of DRD2 rs4648317 or COMT Val158Met genotypes.
   Conclusions. Our results suggest that the relationship between pTBI-related aggression and the dopaminergic system is modulated by lesion location. Potentially lesion location could represent an easy-to-use, widely available, para-clinical marker to help in the development of an individualized therapeutic approach to pTBI-related pathological aggression.
C1 [Pardini, Matteo; Amore, Mario] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Mat, Genoa, Italy.
   [Pardini, Matteo] Univ Genoa, Magnet Resonance Res Ctr Nervous Syst Dis, Genoa, Italy.
   [Krueger, Frank] George Mason Univ, Mol Neurosci Dept, Fairfax, VA 22030 USA.
   [Krueger, Frank; Strenziok, Maren] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA.
   [Hodgkinson, Colin A.; Goldman, David] NIAAA, Neurogenet Lab, NIH, Bethesda, MD USA.
   [Raymont, Vanessa] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.
   [Wassermann, Eric M.] NINDS, Behav Neurol Unit, NIH, Bethesda, MD 20892 USA.
   [Grafman, Jordan H.] Rehabil Inst Chicago, Chicago, IL 60611 USA.
RP Grafman, JH (reprint author), Rehabil Inst Chicago, Coleman Chair Phys Med & Rehabil, 345 East Super St, Chicago, IL 60611 USA.
EM jgrafman@northwestern.edu
RI Goldman, David/F-9772-2010
OI Goldman, David/0000-0002-1724-5405
FU U.S. National Institute of Neurological Disorders and Stroke; U.S. Army
   Medical Research and Material Command; AKWO, Lavagna (Genoa) Italy
FX The work was supported by the U.S. National Institute of Neurological
   Disorders and Stroke intramural research program and a project grant
   from the U.S. Army Medical Research and Material Command administrated
   by the Henry M Jackson Foundation (Vietnam Head Injury Study Phase III:
   a 30-year post-injury follow-up study). The views expressed in this
   article are those of the authors and do not necessarily reflect the
   official policy or position of the Department of the Navy, the
   Department of Defense, or the U.S. Government. M. P., F. K., and J.G.
   had full access to all the data in the study and take responsibility for
   the integrity of the data and the accuracy of the data analysis. M. P.
   thanks the nonprofit association AKWO, Lavagna (Genoa) Italy, for its
   unrestricted support.
NR 46
TC 2
Z9 2
U1 2
U2 12
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD OCT
PY 2014
VL 19
IS 5
BP 382
EP 390
DI 10.1017/S1092852914000108
PG 9
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AT0JC
UT WOS:000344621600005
PM 24618367
ER

PT J
AU Mirigian, LS
   Makareeva, E
   Leikin, S
AF Mirigian, Lynn S.
   Makareeva, Elena
   Leikin, Sergey
TI Pulse-chase analysis of procollagen biosynthesis by azidohomoalanine
   labeling
SO CONNECTIVE TISSUE RESEARCH
LA English
DT Article
DE Azidohomoalanine; collagen; metabolic labeling; osteogenesis imperfecta;
   pulse-chase
ID PERINATAL OSTEOGENESIS IMPERFECTA; NEWLY SYNTHESIZED PROTEINS;
   EHLERS-DANLOS-SYNDROME; TRIPLE-HELIX; QUANTITATIVE PROTEOMICS; I
   PROCOLLAGEN; AMINO-ACIDS; CELL-CULTURE; COLLAGEN; SILAC
AB Disruptions in procollagen synthesis, trafficking and secretion by cells occur in multiple connective tissue diseases. Traditionally, these disruptions are studied by pulse-chase labeling with radioisotopes. However, significant DNA damage, excessive accumulation of reactive oxygen species and formation of other free radicals have been well documented in the literature at typical radioisotope concentrations used for pulse-chase experiments. Therefore, it is important to keep in mind that the resulting cell stress response might affect interpretation of the data, particularly with respect to abnormal function of procollagen-producing cells. In this study, we describe an alternative method of pulse-chase procollagen labeling with azidohomoalanine, a noncanonical amino acid that replaces methionine in newly synthesized protein chains and can be detected via highly selective click chemistry reactions. At least in fibroblast culture, this approach is more efficient than traditional radioisotopes and has fewer, if any, unintended effects on cell function. To illustrate its applications, we demonstrate delayed procollagen folding and secretion by cells from an osteogenesis imperfecta patient with a Cys substitution for Gly766 in the triple helical region of the alpha 1(I) chain of type I procollagen.
C1 [Mirigian, Lynn S.; Makareeva, Elena; Leikin, Sergey] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
   [Mirigian, Lynn S.] Univ Texas Med Branch, Dept Cell Biol, Galveston, TX 77555 USA.
RP Leikin, S (reprint author), NICHD, NIH, Bldg 9,Rm 1E-127, Bethesda, MD 20892 USA.
EM leikins@mail.nih.gov
RI Leikin, Sergey/A-5518-2008
OI Leikin, Sergey/0000-0001-7095-0739
FU NICHD, NIH
FX This work was funded by the Intramural Research Program, NICHD, NIH.
NR 48
TC 2
Z9 2
U1 1
U2 12
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0300-8207
EI 1607-8438
J9 CONNECT TISSUE RES
JI Connect. Tissue Res.
PD OCT-DEC
PY 2014
VL 55
IS 5-6
BP 403
EP 410
DI 10.3109/03008207.2014.959120
PG 8
WC Cell Biology; Orthopedics
SC Cell Biology; Orthopedics
GA AS8EU
UT WOS:000344483700012
PM 25159826
ER

PT J
AU Restrepo, NA
   Spencer, KL
   Goodloe, R
   Garrett, TA
   Heiss, G
   Buzkova, P
   Jorgensen, N
   Jensen, RA
   Matise, TC
   Hindorff, LA
   Klein, BEK
   Klein, R
   Wong, TY
   Cheng, CY
   Cornes, BK
   Tai, ES
   Ritchie, MD
   Haines, JL
   Crawford, DC
AF Restrepo, Nicole A.
   Spencer, Kylee L.
   Goodloe, Robert
   Garrett, Tiana A.
   Heiss, Gerardo
   Buzkova, Petra
   Jorgensen, Neal
   Jensen, Richard A.
   Matise, Tara C.
   Hindorff, Lucia A.
   Klein, Barbara E. K.
   Klein, Ronald
   Wong, Tien Y.
   Cheng, Ching-Yu
   Cornes, Belinda K.
   Tai, E. -Shyong
   Ritchie, Marylyn D.
   Haines, Jonathan L.
   Crawford, Dana C.
TI Genetic Determinants of Age-Related Macular Degeneration in Diverse
   Populations From the PAGE Study
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE age-related macular degeneration; CFH Y402H; ARMS2 A69S; PAGE Study;
   genetic epidemiology
ID COMPLEMENT-FACTOR-H; GENOME-WIDE ASSOCIATION; NUTRITION EXAMINATION
   SURVEY; CARDIOVASCULAR RISK-FACTORS; SINGAPORE MALAY EYE;
   NATIONAL-HEALTH; ATHEROSCLEROSIS RISK; JAPANESE POPULATION; CHINESE
   POPULATION; CIGARETTE-SMOKING
AB PURPOSE. Substantial progress has been made in identifying susceptibility variants for AMD in European populations; however, few studies have been conducted to understand the role these variants play in AMD risk in diverse populations. The present study aims to examine AMD risk across diverse populations in known and suspected AMD complement factor and lipid-related loci.
   METHODS. Targeted genotyping was performed across study sites for AMD and lipid trait-associated single nucleotide polymorphism (SNPs). Genetic association tests were performed at individual sites and then meta-analyzed using logistic regression assuming an additive genetic model stratified by self-described race/ethnicity. Participants included cases with early or late AMD and controls with no signs of AMD as determined by fundus photography. Populations included in this study were European Americans, African Americans, Mexican Americans, and Singaporeans from the Population Architecture using Genomics and Epidemiology (PAGE) study.
   RESULTS. Index variants of AMD, rs1061170 (CFH) and rs10490924 (ARMS2), were associated with AMD at P = 3.05 X 10(-8) and P = 6.36 X 10(-6), respectively, in European Americans. In general, none of the major AMD index variants generalized to our non-European populations with the exception of rs10490924 in Mexican Americans at an uncorrected P value < 0.05. Four lipid-associated SNPS (LPL rs328, TRIB1 rs6987702, CETP rs1800775, and KCTD10/MVK rs2338104) were associated with AMD in African Americans and Mexican Americans (P < 0.05), but these associations did not survive strict corrections for multiple testing.
   CONCLUSIONS. While most associations did not generalize in the non-European populations, variants within lipid-related genes were found to be associated with AMD. This study highlights the need for larger well-powered studies in non-European populations.
C1 [Restrepo, Nicole A.; Goodloe, Robert; Haines, Jonathan L.; Crawford, Dana C.] Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN 37232 USA.
   [Spencer, Kylee L.] Heidelberg Univ, Dept Biol & Environm Sci, Tiffin, OH USA.
   [Garrett, Tiana A.; Heiss, Gerardo] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
   [Buzkova, Petra; Jorgensen, Neal] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Jensen, Richard A.] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
   [Matise, Tara C.] Rutgers State Univ, Dept Genet, Piscataway, NJ USA.
   [Hindorff, Lucia A.] NHGRI, Div Genom Med, NIH, Bethesda, MD 20892 USA.
   [Klein, Barbara E. K.; Klein, Ronald] Univ Wisconsin, Sch Med & Publ Hlth, Dept Ophthalmol & Visual Sci, Madison, WI USA.
   [Wong, Tien Y.; Cheng, Ching-Yu; Cornes, Belinda K.; Tai, E. -Shyong] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
   [Wong, Tien Y.; Cheng, Ching-Yu] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117595, Singapore.
   [Wong, Tien Y.; Cheng, Ching-Yu; Tai, E. -Shyong] Natl Univ Hlth Syst, Singapore, Singapore.
   [Cheng, Ching-Yu; Tai, E. -Shyong] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore.
   [Cheng, Ching-Yu; Tai, E. -Shyong] Duke Natl Univ Singapore, Grad Sch Med, Singapore, Singapore.
   [Tai, E. -Shyong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore.
   [Ritchie, Marylyn D.] Penn State Univ, Ctr Syst Genom, Dept Biochem & Mol Biol, University Pk, PA 16802 USA.
   [Crawford, Dana C.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
RP Crawford, DC (reprint author), Vanderbilt Univ, Ctr Human Genet Res, 2215 Garland Ave,519 Light Hall, Nashville, TN 37232 USA.
EM dana.crawford@case.edu
OI Tai, E Shyong/0000-0003-2929-8966
FU National Human Genome Research Institute (NHGRI); CALiCo [U01HG004803];
   EAGLE [U01HG004798]; MEC [U01HG004802]; WHI [U01HG004790]; Coordinating
   Center [U01HG004801-01]; NHGRI ARRA; National Heart, Lung, and Blood
   Institute (NHLBI) [N01-HC-55015, N01-HC-55016, N01-HC-55018,
   N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022]; NHLBI
   [N01-HC-85079, N01-HC-85086, N01-HC-35129, N01-HC-15103, N01 HC-55222,
   N01-HC-75150, N01-HC-45133, N01-HC-85239, HHSN268201200036C,
   U01HL080295, R01 HL087652, HL105756]; National Institute of Neurological
   Disorders and Stroke; National Medical Research Council [0796/2003,
   IRG07nov013, IRG09nov014, STaR/0003/2008, CG/SERI/2010]; Biomedical
   Research Council of Singapore (BMRC) [03/1/27/18/216, 05/1/36/19/413];
   NMRC [CSA/033/2012]; National Center of Advancing Translational
   Technologies CTSI [UL1TR000124]; National Institute of Diabetes and
   Digestive and Kidney Diseases [DK063491]; Cedars-Sinai Board of
   Governors' Chair in Medical Genetics (JIR); CDC; National Institutes of
   Mental Health
FX Supported by: National Human Genome Research Institute (NHGRI; PAGE
   study); U01HG004803 (CALiCo); U01HG004798 (EAGLE); U01HG004802 (MEC);
   U01HG004790 (WHI); U01HG004801-01 (Coordinating Center), and their
   respective NHGRI ARRA supplements;; National Heart, Lung, and Blood
   Institute (NHLBI) contracts N01-HC-55015, N01-HC-55016, N01-HC-55018,
   N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022 (ARIC study);;
   NHLBI contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129,
   N01-HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, N01-HC-85239,
   HHSN268201200036C, Grants U01HL080295, R01 HL087652, and HL105756, with
   additional contribution from the National Institute of Neurological
   Disorders and Stroke (CHS study);; National Medical Research Council
   (Grants 0796/2003, IRG07nov013, IRG09nov014, STaR/0003/2008 and
   CG/SERI/2010) and Biomedical Research Council (Grants 09/1/35/19/616;
   SiMES study), Singapore;; Biomedical Research Council of Singapore (BMRC
   Grant No. 03/1/27/18/216 and 05/1/36/19/413; SP2 study); and; an award
   from NMRC (CSA/033/2012; C-YC).; Handling and genotyping of DNA was
   supported in part by National Center of Advancing Translational
   Technologies CTSI Grant UL1TR000124 and National Institute of Diabetes
   and Digestive and Kidney Diseases Grant DK063491 to the Southern
   California Diabetes Endocrinology Research Center and Cedars-Sinai Board
   of Governors' Chair in Medical Genetics (JIR). See also
   http://www.chs-nhlbi.org/pi.htm. The study participants were derived
   from NHANES, and these studies are supported by the CDC. Assistance with
   phenotype harmonization, SNP selection and annotation, data cleaning,
   data management, integration and dissemination, and general study
   coordination was provided by the PAGE Coordinating Center. The National
   Institutes of Mental Health also contributes to the support for the
   Coordinating Center. The Singapore Tissue Network and the Genome
   Institute of Singapore, Agency for Science, Technology and Research,
   Singapore provided services for tissue archival and genotyping,
   respectively. The authors alone are responsible for the content and
   writing of the paper.
NR 84
TC 7
Z9 7
U1 0
U2 3
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD OCT
PY 2014
VL 55
IS 10
DI 10.1167/iovs.14-14246
PG 12
WC Ophthalmology
SC Ophthalmology
GA AT1ZS
UT WOS:000344730500033
PM 25205864
ER

PT J
AU Smith, DB
   Simmonds, P
   Jameel, S
   Emerson, SU
   Harrison, TJ
   Meng, XJ
   Okamoto, H
   Van der Poel, WHM
   Purdy, MA
AF Smith, Donald B.
   Simmonds, Peter
   Jameel, Shahid
   Emerson, Suzanne U.
   Harrison, Tim J.
   Meng, Xiang-Jin
   Okamoto, Hiroaki
   Van der Poel, Wim H. M.
   Purdy, Michael A.
CA Int Comm Taxonomy Viruses
TI Consensus proposals for classification of the family Hepeviridae
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID HEPATITIS-E VIRUS; GENETIC-VARIABILITY; PHYLOGENETIC ANALYSIS;
   MOLECULAR-CLONING; WILD RATS; C VIRUS; HEV; GENOTYPE; CHINA;
   RECOMBINATION
AB The family Hepeviridae consists of positive-stranded RNA viruses that infect a wide range of mammalian species, as well as chickens and trout. A subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. Current published descriptions of the taxonomical divisions within the family Hepeviridae are contradictory in relation to the assignment of species and genotypes. Through analysis of existing sequence information, we propose a taxonomic scheme in which the family is divided into the genera Orthohepevirus (all mammalian and avian hepatitis E virus (HEV) isolates) and Piscihepevirus (cutthroat trout virus). Species within the genus Orthohepevirus are designated Orthohepevirus A (isolates from human, pig, wild boar, deer, mongoose, rabbit and camel), Orthohepevirus B (isolates from chicken), Orthohepevirus C (isolates from rat, greater bandicoot, Asian musk shrew, ferret and mink) and Orthohepevirus D (isolates from bat). Proposals are also made for the designation of genotypes within the human and rat HEVs. This hierarchical system is congruent with hepevirus phylogeny, and the three classification levels (genus, species and genotype) are consistent with, and reflect discontinuities in the ranges of pairwise distances between amino acid sequences. Adoption of this system would include the avoidance of host names in taxonomic identifiers and provide a logical framework for the assignment of novel variants.
C1 [Smith, Donald B.; Simmonds, Peter] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland.
   [Jameel, Shahid] Wellcome Trust DBT India Alliance, Hyderabad, Andhra Pradesh, India.
   [Emerson, Suzanne U.] NIAID, Mol Hepatitis Sect, NIH, Bethesda, MD 20892 USA.
   [Harrison, Tim J.] UCL, London, England.
   [Meng, Xiang-Jin] Virginia Polytech Inst & State Univ, Coll Vet Med, Blacksburg, VA 24061 USA.
   [Okamoto, Hiroaki] Jichi Med Univ, Sch Med, Dept Infect & Immun, Div Virol, Shimotsuke, Tochigi, Japan.
   [Van der Poel, Wim H. M.] Univ Wageningen & Res Ctr, Cent Vet Inst, Lelystad, Netherlands.
   [Purdy, Michael A.] Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD TB Prevent, Div Viral Hepatitis, Atlanta, GA USA.
RP Smith, DB (reprint author), Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland.
EM D.B.Smith@ed.ac.uk
RI Okamoto, Hiroaki/H-4371-2011
OI Okamoto, Hiroaki/0000-0003-0827-0964
FU Wellcome Trust
FX We are grateful to Dr Patrick Woo for sharing the camel HEV isolate
   complete genome sequences ahead of general release. This research was
   supported by a grant from The Wellcome Trust to the Centre for Immunity,
   Infection and Evolution at the University of Edinburgh. This information
   is distributed solely for the purpose of pre-dissemination peer review
   under applicable information quality guidelines. It has not been
   formally disseminated by the Centers for Disease Control and
   Prevention/Agency for Toxic Substances and Disease Registry. It does not
   represent and should not be construed to represent any agency
   determination or policy. Use of trade names is for identification only
   and does not imply endorsement by the US Department of Health and Human
   Services, the Public Health Service, or the Centers for Disease Control
   and Prevention. The findings and conclusions in this report are those of
   the authors and do not necessarily represent the views of the Centers
   for Disease Control and Prevention. The authors declare that they have
   no conflict of interest.
NR 39
TC 117
Z9 118
U1 4
U2 13
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
   BERKS, ENGLAND
SN 0022-1317
EI 1465-2099
J9 J GEN VIROL
JI J. Gen. Virol.
PD OCT
PY 2014
VL 95
BP 2223
EP 2232
DI 10.1099/vir.0.068429-0
PN 10
PG 10
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA AT4LW
UT WOS:000344911900013
PM 24989172
ER

PT J
AU Mohanram, V
   Demberg, T
   Tuero, I
   Vargas-Inchaustegui, D
   Pavlakis, GN
   Felber, BK
   Robert-Guroff, M
AF Mohanram, Venkatramanan
   Demberg, Thorsten
   Tuero, Iskra
   Vargas-Inchaustegui, Diego
   Pavlakis, George N.
   Felber, Barbara K.
   Robert-Guroff, Marjorie
TI Improved flow-based method for HIV/SIV envelope-specific memory B-cell
   evaluation in rhesus macaques
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE HIV; SIV; Envelope-specific memory B cells
ID HIV-1 INFECTION; ANTIBODY; GP120; POPULATIONS; VACCINATION; DEPLETION;
   RESPONSES; BINDING; PROTEIN; BLOOD
AB The ability to elicit potent and long-lasting broadly neutralizing HIV envelope (Env)-specific antibodies has become a key goal for HIV vaccine development. Consequently, the ability to rapidly and efficiently Monitor development of memory B Cells in pre-clinical and clinical vaccine trails is critical for continued progress in vaccine design. We have developed an improved flow cytometry-based method for the rapid and efficient identification of gp120-specific memory B cells in peripheral blood, bone marrow, and mucosal tissues which allows their direct staining without the need for prior cell sorting or enrichment. We demonstrate staining of both HIV and SIV Env-specific memory B cells in PBMC, bone marrow, and rectal tissue of vaccinated and infected rhesus macaques. Validation of the method is illustrated by statistically significant correlations with memory B cell levels quantified by ELISPOT assay and with serum binding antibody titers determined by ELISA. In addition to quantification, this method will bring the power of flow cytometry to the study of homing and trafficking of Env-specific memory B cells. Published by Elsevier B.V.
C1 [Mohanram, Venkatramanan; Demberg, Thorsten; Tuero, Iskra; Vargas-Inchaustegui, Diego; Robert-Guroff, Marjorie] NCI, Sect Immune Biol Retroviral Infect, Vaccine Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
   [Pavlakis, George N.] Natl Canc Inst Frederick, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21702 USA.
   [Felber, Barbara K.] Natl Canc Inst Frederick, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21702 USA.
RP Robert-Guroff, M (reprint author), NCI, NIH, Bldg 41,Room D804, Bethesda, MD 20892 USA.
EM guroffm@mail.nih.gov
RI Mohanram, Venkatramanan/I-3652-2016
FU Intramural Research Program of the National Institutes of Health,
   National Cancer Institute
FX Unconjugated CD4 monoclonal antibodies, OKT4 and T4/19Thy5D7, were
   obtained from the NIH Nonhuman Primate Reagent Resource. This work was
   supported by the Intramural Research Program of the National Institutes
   of Health, National Cancer Institute.
NR 24
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
EI 1872-7905
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD OCT
PY 2014
VL 412
BP 78
EP 84
DI 10.1016/j.jim.2014.06.012
PG 7
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA AT6NN
UT WOS:000345056200008
PM 24953216
ER

PT J
AU Vince, N
   Bashirova, AA
   Lied, A
   Gao, XJ
   Dorrell, L
   McLaren, PJ
   Fellay, J
   Carrington, M
AF Vince, Nicolas
   Bashirova, Arman A.
   Lied, Alexandra
   Gao, Xiaojiang
   Dorrell, Lucy
   McLaren, Paul J.
   Fellay, Jacques
   Carrington, Mary
TI HLA Class I and KIR Genes Do Not Protect Against HIV Type 1 Infection in
   Highly Exposed Uninfected Individuals With Hemophilia A
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE HESN; hemophilia; HIV-1; HLA; KIR
ID GENOME-WIDE ASSOCIATION; TRANSMISSION; RESISTANCE; GENETICS; LIGANDS;
   DISEASE
AB A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-.32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
C1 [Vince, Nicolas; Bashirova, Arman A.; Gao, Xiaojiang; Carrington, Mary] Frederick Natl Lab Canc Res, Leidos Biomed Res, Canc & Inflammat Program, Lab Expt Immunol, Frederick, MD 21702 USA.
   [Vince, Nicolas; Bashirova, Arman A.; Lied, Alexandra; Carrington, Mary] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
   [Dorrell, Lucy] Univ Oxford, Nuffield Dept Med, Oxford OX1 2JD, England.
   [McLaren, Paul J.; Fellay, Jacques] Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland.
   [McLaren, Paul J.; Fellay, Jacques] Swiss Inst Bioinformat, Lausanne, Switzerland.
RP Carrington, M (reprint author), Frederick Natl Lab Canc Res, Leidos Biomed Res, Canc & Inflammat Program, Lab Expt Immunol, 1050 Boyles St, Frederick, MD 21702 USA.
EM carringm@mail.nih.gov
RI Fellay, Jacques/A-6681-2009; SHCS, int. coll. A/G-4083-2011; SHCS,
   all/G-4072-2011
OI Fellay, Jacques/0000-0002-8240-939X; 
FU Ragon Institute of MGH, MIT, and Harvard; Frederick National Laboratory
   for Cancer Research, National Institutes of Health (NIH)
   [HHSN261200800001E]; NIH Intramural Research Support Program, Center for
   Cancer Research, National Institute of Cancer, Frederick National
   Laboratory for Cancer Research
FX This work was supported by the Ragon Institute of MGH, MIT, and Harvard;
   the Frederick National Laboratory for Cancer Research, National
   Institutes of Health (NIH; contract HHSN261200800001E); and the NIH
   Intramural Research Support Program, Center for Cancer Research,
   National Institute of Cancer, Frederick National Laboratory for Cancer
   Research.
NR 15
TC 5
Z9 5
U1 1
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2014
VL 210
IS 7
BP 1047
EP 1051
DI 10.1093/infdis/jiu214
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AT0ED
UT WOS:000344609100007
PM 24719475
ER

PT J
AU Baden, LR
   Walsh, SR
   Seaman, MS
   Johnson, JA
   Tucker, RP
   Kleinjan, JA
   Gothing, JA
   Engelson, BA
   Carey, BR
   Oza, A
   Bajimaya, S
   Peter, L
   Bleckwehl, C
   Abbink, P
   Pau, MG
   Weijtens, M
   Kunchai, M
   Swann, EM
   Wolff, M
   Dolin, R
   Barouch, DH
AF Baden, Lindsey R.
   Walsh, Stephen R.
   Seaman, Michael S.
   Johnson, Jennifer A.
   Tucker, Robert P.
   Kleinjan, Jane A.
   Gothing, Jon A.
   Engelson, Brian A.
   Carey, Brittany R.
   Oza, Avinash
   Bajimaya, Shringkhala
   Peter, Lauren
   Bleckwehl, Chelsea
   Abbink, Peter
   Pau, Maria G.
   Weijtens, Mo
   Kunchai, Meghan
   Swann, Edith M.
   Wolff, Mark
   Dolin, Raphael
   Barouch, Dan H.
TI First-in-Human Evaluation of a Hexon Chimeric Adenovirus Vector
   Expressing HIV-1 Env (IPCAVD 002)
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE HIV vaccine; adenovirus 5 HVR48; safety; immunogenicity; dose escalation
ID NEUTRALIZING ANTIBODIES TARGET; T-CELL RESPONSES; RHESUS-MONKEYS;
   EFFICACY TRIAL; DOUBLE-BLIND; SEROTYPE 5; PROTECTIVE EFFICACY; VACCINE
   TRIALS; IMMUNOGENICITY; INFECTION
AB Background. We report the first-in-human safety and immunogenicity assessment of a prototype hexon chimeric adenovirus (Ad) serotype 5 (Ad5) vector containing the hexon hypervariable regions of Ad serotype 48 (Ad48) and expressing human immunodeficiency virus (HIV) type 1 EnvA.
   Methods. Forty-eight Ad5 and Ad48 seronegative, HIV-uninfected subjects were enrolled in a randomized, double- blind, placebo-controlled, dose escalation phase 1 study. Four groups of 12 subjects received 10(9) to 10(11) viral particles (vp) of the Ad5HVR48. EnvA. 01 vaccine (n= 10 per group) or placebo (n= 2 per group) at week 0 or weeks 0, 4, and 24. Safety and immunogenicity were assessed.
   Results. Self-limited reactogenicity was observed after the initial immunization in the highest (10(11) vp) dose group. Responses in vaccinees included Ad48 neutralizing antibody (nAb) titers higher than Ad5 nAb titers, EnvA-specific enzyme-linked immunosorbent assay titers, and EnvA-specific enzyme-linked immunospot assay responses, and these responses generally persisted at week 52. At week 28 in the 10(9), 10(10), and 10(11) vp 3-dose groups, geometric mean EnvA enzyme-linked immunosorbent assay titers were 5721, 10 929, and 3420, respectively, and Ad48 nAb titers were a median of 1.7-fold higher than for Ad5.
   Conclusions. Ad5HVR48. ENVA. 01 was safe, well tolerated, and immunogenic at all doses tested. Vector-elicited nAb responses were greater for Ad48 than Ad5, confirming that Ad-specific nAbs in humans are primarily, but not exclusively, directed against the hexon hypervariable regions.
   Clinical Trials Registration. NCT00695877.
C1 [Baden, Lindsey R.; Walsh, Stephen R.; Johnson, Jennifer A.; Tucker, Robert P.; Kleinjan, Jane A.; Gothing, Jon A.; Engelson, Brian A.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA.
   [Baden, Lindsey R.; Walsh, Stephen R.; Seaman, Michael S.; Carey, Brittany R.; Oza, Avinash; Bajimaya, Shringkhala; Peter, Lauren; Bleckwehl, Chelsea; Abbink, Peter; Dolin, Raphael; Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA.
   [Baden, Lindsey R.; Walsh, Stephen R.; Seaman, Michael S.; Johnson, Jennifer A.; Dolin, Raphael; Barouch, Dan H.] Harvard Univ, Sch Med, Boston, MA USA.
   [Kunchai, Meghan; Wolff, Mark] EMMES Corp, Rockville, MD USA.
   [Swann, Edith M.] NIAID, Div AIDS, Bethesda, MD 20892 USA.
   [Pau, Maria G.; Weijtens, Mo] Crucell Holland BV, Leiden, Netherlands.
RP Walsh, SR (reprint author), Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, 3 Blackfan Circle, Boston, MA 02115 USA.
EM srwalsh@bidmc.harvard.edu
FU NIH [AI066305, AI078526, AI096040, RR025758, TR000170]; Ragon Institute
   of MGH, MIT, and Harvard
FX This work was supported by the NIH (grants AI066305, AI078526, AI096040,
   RR025758, and TR000170) and the Ragon Institute of MGH, MIT, and
   Harvard.
NR 38
TC 3
Z9 3
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2014
VL 210
IS 7
BP 1052
EP 1061
DI 10.1093/infdis/jiu217
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AT0ED
UT WOS:000344609100008
PM 24719474
ER

PT J
AU Glushakova, S
   Balaban, A
   McQueen, PG
   Coutinho, R
   Miller, JL
   Nossal, R
   Fairhurst, RM
   Zimmerberg, J
AF Glushakova, Svetlana
   Balaban, Amanda
   McQueen, Philip G.
   Coutinho, Rosane
   Miller, Jeffery L.
   Nossal, Ralph
   Fairhurst, Rick M.
   Zimmerberg, Joshua
TI Hemoglobinopathic Erythrocytes Affect the Intraerythrocytic
   Multiplication of Plasmodium falciparum In Vitro
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE hemoglobinopathy; malaria; Plasmodium falciparum; sickle hemoglobin;
   thalassemia
ID MALARIA PARASITE RELEASE; INFECTED ERYTHROCYTES; IRON-DEFICIENCY;
   GROWTH-RATES; HUMAN HOST; PROTECTION; MECHANISM; BLOOD; GENE;
   SUSCEPTIBILITY
AB Background. The mechanisms by which a-thalassemia and sickle cell traits confer protection from severe Plasmodium falciparum malaria are not yet fully elucidated. We hypothesized that hemoglobinopathic erythrocytes reduce the intraerythrocytic multiplication of P. falciparum, potentially delaying the development of life-threatening parasite densities until parasite clearing immunity is achieved.
   Methods. We developed a novel in vitro assay to quantify the number of merozoites released from an individual schizont, termed the "intraerythrocytic multiplication factor" (IMF).
   Results. P. falciparum (3D7 line) schizonts produce variable numbers of merozoites in all erythrocyte types tested, with median IMFs of 27, 27, 29, 23, and 23 in control, HbAS, HbSS, and alpha- and beta-thalassemia trait erythrocytes, respectively. IMF correlated strongly (r(2) = 0.97; P < .001) with mean corpuscular hemoglobin concentration, and varied significantly with mean corpuscular volume and hemoglobin content. Reduction of IMFs in thalassemia trait erythrocytes was confirmed using clinical parasite isolates with different IMFs. Mathematical modeling of the effect of IMF on malaria progression indicates that the lower IMF in thalassemia trait erythrocytes limits parasite density and anemia severity over the first 2 weeks of parasite replication.
   Conclusions. P. falciparum IMF, a parasite heritable virulence trait, correlates with erythrocyte indices and is reduced in thalassemia trait erythrocytes. Parasite IMF should be examined in other low-indices erythrocytes.
C1 [Glushakova, Svetlana; Balaban, Amanda; Nossal, Ralph; Zimmerberg, Joshua] Eunice Kennedy Shriver Natl Inst Child Hlth & Dev, Program Phys Biol, NIH, Bethesda, MD USA.
   [McQueen, Philip G.] NIH, Math & Stat Comp Lab, Div Computat Biosci, Ctr Informat Technol, Bethesda, MD 20892 USA.
   [Coutinho, Rosane] Natl Inst Biomed Imaging & Bioengn, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD USA.
   [Miller, Jeffery L.] NIDDKD, Mol Med Branch, NIH, Bethesda, MD USA.
   [Fairhurst, Rick M.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA.
RP Fairhurst, RM (reprint author), NIAID, Lab Malaria & Vector Res, NIH, 12735 Twinbrook Pkwy,Rm 3E-10A, Rockville, MD 20852 USA.
EM rfairhurst@niaid.nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD); National Institute of Diabetes and Digestive and
   Kidney Diseases (NIDDK); National Institute of Biomedical Imaging and
   Bioengineering (NIBIB); Center for Information Technology (CIT);
   National Institute of Allergy and Infectious Diseases (NIAID), National
   Institutes of Health
FX This work was supported by the Intramural Research Programs of the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD), National Institute of Diabetes and Digestive and
   Kidney Diseases (NIDDK), National Institute of Biomedical Imaging and
   Bioengineering (NIBIB), Center for Information Technology (CIT), and
   National Institute of Allergy and Infectious Diseases (NIAID), National
   Institutes of Health.
NR 43
TC 4
Z9 4
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2014
VL 210
IS 7
BP 1100
EP 1109
DI 10.1093/infdis/jiu203
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AT0ED
UT WOS:000344609100014
PM 24688070
ER

PT J
AU Ondigo, BN
   Hodges, JS
   Ireland, KF
   Magak, NG
   Lanar, DE
   Dutta, S
   Narum, DL
   Park, GS
   Ofulla, AV
   John, CC
AF Ondigo, Bartholomew N.
   Hodges, James S.
   Ireland, Kathleen F.
   Magak, Ng'wena G.
   Lanar, David E.
   Dutta, Sheetij
   Narum, David L.
   Park, Gregory S.
   Ofulla, Ayub V.
   John, Chandy C.
TI Estimation of Recent and Long-Term Malaria Transmission in a Population
   by Antibody Testing to Multiple Plasmodium falciparum Antigens
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE antibody; elimination; half-life; malaria; Plasmodium falciparum
ID NATURALLY ACQUIRED ANTIBODIES; LIVED PLASMA-CELLS; CLINICAL MALARIA;
   MEROZOITE ANTIGENS; HUMORAL IMMUNITY; SURFACE-ANTIGENS; KENYAN CHILDREN;
   MIDDLE AMERICA; LOW-PREVALENCE; HIGHLAND AREA
AB Background. Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs.
   Methods. The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission.
   Results. Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens.
   Conclusions. Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.
C1 [Ondigo, Bartholomew N.] Maseno Univ, Dept Biomed Sci & Technol, Maseno, Kenya.
   [Ondigo, Bartholomew N.; Lanar, David E.; Dutta, Sheetij; John, Chandy C.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya.
   [Hodges, James S.] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55414 USA.
   [Ireland, Kathleen F.; John, Chandy C.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55414 USA.
   [Magak, Ng'wena G.] Maseno Univ, Dept Med Physiol, Maseno, Kenya.
   [Narum, David L.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
   [Park, Gregory S.; Ofulla, Ayub V.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA.
RP John, CC (reprint author), Univ Minnesota, Sch Med, Div Global Pediat, 717 Delaware St SE,Room 366,MC 1932, Minneapolis, MN 55414 USA.
EM ccj@umn.edu
FU National Institute of Allergy and Infectious Diseases (NIAID) [U01
   AI056270]; Fogarty International Center [D43 TW0080085, R25 TW009345];
   NIAID, National Institutes of Health (NIH)
FX This work was supported by grants to C. C. J. from the National
   Institute of Allergy and Infectious Diseases (NIAID, U01 AI056270) and
   the Fogarty International Center (D43 TW0080085 and R25 TW009345). This
   research was supported, in part, by the Intramural Research Program of
   the NIAID, National Institutes of Health (NIH).
NR 39
TC 12
Z9 12
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2014
VL 210
IS 7
BP 1123
EP 1132
DI 10.1093/infdis/jiu225
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AT0ED
UT WOS:000344609100017
PM 24737801
ER

PT J
AU Pardini, M
   Sethi, V
   Muhlert, N
   Yaldizli, O
   Palesi, F
   Altmann, D
   Ron, M
   Wheeler-Kingshott, C
   Miller, D
   Chard, D
AF Pardini, Matteo
   Sethi, Varun
   Muhlert, Nils
   Yaldizli, Oezguer
   Palesi, Fulvia
   Altmann, Daniel
   Ron, Maria
   Wheeler-Kingshott, Claudia
   Miller, David
   Chard, Declan
TI NETWORK EFFICIENCY AND COGNITIVE DEFICITS IN MS
SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
LA English
DT Meeting Abstract
CT Meeting of the Associatiion-of-British-Neurologists
CY MAY 07-09, 2014
CL Cardiff, WALES
SP Assoc British Neurologists
C1 [Pardini, Matteo; Sethi, Varun; Muhlert, Nils; Yaldizli, Oezguer; Altmann, Daniel; Ron, Maria; Wheeler-Kingshott, Claudia; Miller, David; Chard, Declan] UCL Inst Neurol, Genoa, Italy.
   [Pardini, Matteo] Univ Genoa, Genoa, Italy.
   [Sethi, Varun] NINDS, NIH, Bethesda, MD 20892 USA.
   [Muhlert, Nils] Cardiff Univ, Cardiff CF10 3AX, S Glam, Wales.
   [Yaldizli, Oezguer] Univ Basel Hosp, CH-4031 Basel, Switzerland.
   [Palesi, Fulvia] Univ Pavia, I-27100 Pavia, Italy.
   [Altmann, Daniel] London Sch Hyg & Trop Med, London WC1, England.
   [Chard, Declan] Univ Coll London Hosp UCLH Biomed, Natl Inst Hlth Res, London, England.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-3050
EI 1468-330X
J9 J NEUROL NEUROSUR PS
JI J. Neurol. Neurosurg. Psychiatry
PD OCT
PY 2014
VL 85
IS 10
MA 141
DI 10.1136/jnnp-2014-309236.141
PG 1
WC Clinical Neurology; Psychiatry; Surgery
SC Neurosciences & Neurology; Psychiatry; Surgery
GA AS7SW
UT WOS:000344456000142
ER

PT J
AU Lu, H
   Yan, C
   Quan, XX
   Yang, XP
   Zhang, JL
   Bian, YS
   Chen, Z
   Van Waes, C
AF Lu, Hai
   Yan, Carol
   Quan, Xin Xin
   Yang, Xinping
   Zhang, Jialing
   Bian, Yansong
   Chen, Zhong
   Van Waes, Carter
TI CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to
   Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and
   Neck Cancer
SO NEOPLASIA
LA English
DT Article
ID PROTEIN-KINASE CK2; KAPPA-B; CARCINOMA; P53; IDENTIFICATION; P73;
   DIFFERENTIATION; ASSOCIATION; INDUCTION; APOPTOSIS
AB Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that modulates diverse signal cascades regulating cell fate and growth. We previously showed that CK2 is often aberrantly expressed and activated in head and neck squamous cell carcinomas (HNSCC), concomitantly with mutant (mt) tumor suppressor TP53, and inactivation of its family member, TAp73. Unexpectedly, we observed that classical stem cell genes Nanog, Sox2, and Oct4, are overexpressed in HNSCC with inactivated TAp73 and mtTP53. However, the potential relationship between CK2, TAp73 inactivation, and CSC phenotype is unknown. We reveal that inhibition of CK2 by pharmacologic inhibitors or siRNA inhibits the expression of CSC genes and side population (SP), while enhancing TAp73mRNA and protein expression. Conversely, CK2 inhibitor attenuation of CSC protein expression and the SP by was abrogated by TAp73 siRNA. Bioinformatic analysis uncovered a single predicted CK2 threonine phosphorylation site (T27) within the N-terminal transactivation domain of TAp73. Nuclear CK2 and TAp73 interaction, confirmed by co-immunoprecipitation, was attenuated by CK2 inhibitor, or a T27A point-mutation of this predicted CK2 threonine phospho-acceptor site of TAp73. Further, T27A mutation attenuated phosphorylation, while enhancing TAp73 function in repressing CSC gene expression and SP cells. A new CK2 inhibitor, CX-4945, inhibited CSC related SP cells, clonogenic survival, and spheroid formation. Our study unveils a novel regulatory mechanism whereby aberrant CK2 signaling inhibits TAp73 to promote the expression of CSC genes and phenotype.
C1 [Lu, Hai; Yan, Carol; Quan, Xin Xin; Yang, Xinping; Zhang, Jialing; Bian, Yansong; Chen, Zhong; Van Waes, Carter] NIDCD, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD 20892 USA.
   [Lu, Hai] Southern Med Univ, Zhujiang Hosp, Orthopaed Ctr, Guangzhou, Guangdong, Peoples R China.
   [Yan, Carol] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20892 USA.
RP Van Waes, C (reprint author), NIDCD, Head & Neck Surg Branch, NIH, 10-5D55,MSC 1419, Bethesda, MD 20892 USA.
EM chenz@nidcd.nih.gov; vanwaesc@nidcd.nih.gov
FU NIDCD Intramural Research Projects by HHMI-NIH Scholars Program
   [Z01-DC-000016, DC-000073. CY]
FX Grant support: HL, XXQ, XY, JZ, YB, ZC and CVW, supported by NIDCD
   Intramural Research Projects Z01-DC-000016 and DC-000073. CY, supported
   by the HHMI-NIH Scholars Program.
NR 33
TC 5
Z9 6
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1522-8002
EI 1476-5586
J9 NEOPLASIA
JI Neoplasia
PD OCT
PY 2014
VL 16
IS 10
BP 789
EP 800
DI 10.1016/j.neo.2014.08.014
PG 12
WC Oncology
SC Oncology
GA AS8CK
UT WOS:000344477700002
PM 25379016
ER

PT J
AU Key, FM
   Peter, B
   Dennis, MY
   Huerta-Sanchez, E
   Tang, W
   Prokunina-Olsson, L
   Nielsen, R
   Andres, AM
AF Key, Felix M.
   Peter, Benjamin
   Dennis, Megan Y.
   Huerta-Sanchez, Emilia
   Tang, Wei
   Prokunina-Olsson, Ludmila
   Nielsen, Rasmus
   Andres, Aida M.
TI Selection on a Variant Associated with Improved Viral Clearance Drives
   Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)
SO PLOS GENETICS
LA English
DT Article
ID HEPATITIS-C VIRUS; APPROXIMATE BAYESIAN COMPUTATION; PERSISTENT LCMV
   INFECTION; GENETIC-VARIATION; POSITIVE SELECTION; NATURAL-SELECTION;
   RIBAVIRIN THERAPY; HUMAN-POPULATIONS; HUMAN GENOMES; IL28B
AB Interferon lambda 4 gene (IFNL4) encodes IFN-lambda 4, a new member of the IFN-lambda family with antiviral activity. In humans IFNL4 open reading frame is truncated by a polymorphic frame-shift insertion that eliminates IFN-lambda 4 and turns IFNL4 into a polymorphic pseudogene. Functional IFN-lambda 4 has antiviral activity but the elimination of IFN-lambda 4 through pseudogenization is strongly associated with improved clearance of hepatitis C virus (HCV) infection. We show that functional IFN-lambda 4 is conserved and evolutionarily constrained in mammals and thus functionally relevant. However, the pseudogene has reached moderately high frequency in Africa, America, and Europe, and near fixation in East Asia. In fact, the pseudogenizing variant is among the 0.8% most differentiated SNPs between Africa and East Asia genome-wide. Its raise in frequency is associated with additional evidence of positive selection, which is strongest in East Asia, where this variant falls in the 0.5% tail of SNPs with strongest signatures of recent positive selection genome-wide. Using a new Approximate Bayesian Computation (ABC) approach we infer that the pseudogenizing allele appeared just before the out-of-Africa migration and was immediately targeted by moderate positive selection; selection subsequently strengthened in European and Asian populations resulting in the high frequency observed today. This provides evidence for a changing adaptive process that, by favoring IFN-lambda 4 inactivation, has shaped present-day phenotypic diversity and susceptibility to disease.
C1 [Key, Felix M.; Andres, Aida M.] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany.
   [Peter, Benjamin; Nielsen, Rasmus] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA.
   [Dennis, Megan Y.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA.
   [Huerta-Sanchez, Emilia] Univ Calif Merced, Sch Nat Sci, Merced, CA USA.
   [Tang, Wei; Prokunina-Olsson, Ludmila] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
RP Key, FM (reprint author), Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany.
EM aida_andres@eva.mpg.de
RI Andres, Aida/B-4088-2014; Nielsen, Rasmus/D-4405-2009
OI Andres, Aida/0000-0002-8590-9672; Prokunina-Olsson,
   Ludmila/0000-0002-9622-2091; Nielsen, Rasmus/0000-0003-0513-6591
FU Max Planck Society; National Institute of Neurological Disorder and
   Stroke of the U.S. National Institutes of Health [K99NS083627]; NCI/NIH;
   U.S. NIH [R01HG003229, R01HG003229-08S2]
FX FMK and AMA are funded by the Max Planck Society. MYD is supported by
   the National Institute of Neurological Disorder and Stroke of the U.S.
   National Institutes of Health (award K99NS083627). WT and LPO are
   supported by the Intramural Research Program of the NCI/NIH. RN and EHS
   are supported by research grants R01HG003229 (RN) and R01HG003229-08S2
   (EHS) from the U.S. NIH. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 72
TC 18
Z9 18
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD OCT
PY 2014
VL 10
IS 10
AR e1004681
DI 10.1371/journal.pgen.1004681
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA AT0UR
UT WOS:000344650700046
PM 25329461
ER

PT J
AU Pemov, A
   Sung, HJ
   Hyland, PL
   Sloan, JL
   Ruppert, SL
   Baldwin, AM
   Boland, JF
   Bass, SE
   Lee, HJ
   Jones, KM
   Zhang, XJ
   Mullikin, JC
   Widemann, BC
   Wilson, AF
   Stewart, DR
AF Pemov, Alexander
   Sung, Heejong
   Hyland, Paula L.
   Sloan, Jennifer L.
   Ruppert, Sarah L.
   Baldwin, Andrea M.
   Boland, Joseph F.
   Bass, Sara E.
   Lee, Hyo Jung
   Jones, Kristine M.
   Zhang, Xijun
   Mullikin, James C.
   Widemann, Brigitte C.
   Wilson, Alexander F.
   Stewart, Douglas R.
CA NISC Comparative Sequencing
TI Genetic Modifiers of Neurofibromatosis Type 1-Associated Cafe-au-Lait
   Macule Count Identified Using Multi-platform Analysis
SO PLOS GENETICS
LA English
DT Article
ID GENOTYPE-PHENOTYPE CORRELATION; HEMATOLOGICAL MALIGNANCY; LINKAGE
   ANALYSIS; EXPRESSION; DISEASE; NF1; MUTATIONS; MOUSE; PREDISPOSES;
   RESISTANCE
AB Neurofibromatosis type 1 (NF1) is an autosomal dominant, monogenic disorder of dysregulated neurocutaneous tissue growth. Pleiotropy, variable expressivity and few NF1 genotype-phenotype correlates limit clinical prognostication in NF1. Phenotype complexity in NF1 is hypothesized to derive in part from genetic modifiers unlinked to the NF1 locus. In this study, we hypothesized that normal variation in germline gene expression confers risk for certain phenotypes in NF1. In a set of 79 individuals with NF1, we examined the association between gene expression in lymphoblastoid cell lines with NF1-associated phenotypes and sequenced select genes with significant phenotype/expression correlations. In a discovery cohort of 89 self-reported European-Americans with NF1 we examined the association between germline sequence variants of these genes with cafe-au-lait macule (CALM) count, a tractable, tumor-like phenotype in NF1. Two correlated, common SNPs (rs4660761 and rs7161) between DPH2 and ATP6V0B were significantly associated with the CALM count. Analysis with tiled regression also identified SNP rs4660761 as significantly associated with CALM count. SNP rs1800934 and 12 rare variants in the mismatch repair gene MSH6 were also associated with CALM count. Both SNPs rs7161 and rs4660761 (DPH2 and ATP6V0B) were highly significant in a mega-analysis in a combined cohort of 180 self-reported European-Americans; SNP rs1800934 (MSH6) was near-significant in a meta-analysis assuming dominant effect of the minor allele. SNP rs4660761 is predicted to regulate ATP6V0B, a gene associated with melanosome biology. Individuals with homozygous mutations in MSH6 can develop an NF1-like phenotype, including multiple CALMs. Through a multi-platform approach, we identified variants that influence NF1 CALM count.
C1 [Pemov, Alexander; Stewart, Douglas R.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20850 USA.
   [Sung, Heejong; Wilson, Alexander F.] NHGRI, Genometr Sect, Computat & Stat Genom Branch, NIH, Baltimore, MD USA.
   [Hyland, Paula L.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA.
   [Sloan, Jennifer L.; Ruppert, Sarah L.] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
   [Baldwin, Andrea M.; Widemann, Brigitte C.] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA.
   [Boland, Joseph F.; Bass, Sara E.; Lee, Hyo Jung; Jones, Kristine M.; Zhang, Xijun] NCI, Canc Genom Res Lab, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA.
   [Mullikin, James C.; NISC Comparative Sequencing] NHGRI, NIH Intramural Sequencing Ctr, Rockville, MD USA.
RP Pemov, A (reprint author), NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20850 USA.
EM drstewart@mail.nih.gov
FU Division of Intramural Research of the National Human Genome Research
   Institute; Intramural Research Program of the National Cancer Institute
FX The work was supported by the Division of Intramural Research of the
   National Human Genome Research Institute and the Intramural Research
   Program of the National Cancer Institute. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 76
TC 3
Z9 3
U1 3
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD OCT
PY 2014
VL 10
IS 10
AR e1004575
DI 10.1371/journal.pgen.1004575
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA AT0UR
UT WOS:000344650700003
PM 25329635
ER

PT J
AU Reidy, M
   Sharma, R
   Shastry, S
   Roberts, BL
   Albino-Flores, I
   Wickner, S
   Masison, DC
AF Reidy, Michael
   Sharma, Ruchika
   Shastry, Shankar
   Roberts, Brittany-Lee
   Albino-Flores, Ivan
   Wickner, Sue
   Masison, Daniel C.
TI Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
SO PLOS GENETICS
LA English
DT Article
ID PEPTIDE-BINDING FRAGMENT; URE3 PRION PROPAGATION; FINGER-LIKE REGION;
   SACCHAROMYCES-CEREVISIAE; YEAST HSP40; CRYSTAL-STRUCTURE; PSI+ PRION;
   IN-VIVO; MOLECULAR CHAPERONES; AGGREGATED PROTEINS
AB Hsp100 family chaperones of microorganisms and plants cooperate with the Hsp70/Hsp40/NEF system to resolubilize and reactivate stress-denatured proteins. In yeast this machinery also promotes propagation of prions by fragmenting prion polymers. We previously showed the bacterial Hsp100 machinery cooperates with the yeast Hsp40 Ydj1 to support yeast thermotolerance and with the yeast Hsp40 Sis1 to propagate [PSI+] prions. Here we find these Hsp40s similarly directed specific activities of the yeast Hsp104-based machinery. By assessing the ability of Ydj1-Sis1 hybrid proteins to complement Ydj1 and Sis1 functions we show their C-terminal substrate-binding domains determined distinctions in these and other cellular functions of Ydj1 and Sis1. We find propagation of [URE3] prions was acutely sensitive to alterations in Sis1 activity, while that of [PIN+] prions was less sensitive than [URE3], but more sensitive than [PSI+]. These findings support the ideas that overexpressing Ydj1 cures [URE3] by competing with Sis1 for interaction with the Hsp104-based disaggregation machine, and that different prions rely differently on activity of this machinery, which can explain the various ways they respond to alterations in chaperone function.
C1 [Reidy, Michael; Sharma, Ruchika; Roberts, Brittany-Lee; Albino-Flores, Ivan; Masison, Daniel C.] NIDDK, Lab Biochem & Genet, Bethesda, MD 20892 USA.
   [Shastry, Shankar; Wickner, Sue] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
RP Reidy, M (reprint author), NIDDK, Lab Biochem & Genet, Bethesda, MD 20892 USA.
EM danielmas@helix.nih.gov
FU National Institutes of Health (NIH), National Institute of Diabetes,
   Digestive and Kidney Diseases; National Cancer Institute
FX This research was supported by the Intramural Research Program of the
   National Institutes of Health (NIH), National Institute of Diabetes,
   Digestive and Kidney Diseases, and the National Cancer Institute. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
NR 83
TC 14
Z9 15
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD OCT
PY 2014
VL 10
IS 10
AR e1004720
DI 10.1371/journal.pgen.1004720
PG 16
WC Genetics & Heredity
SC Genetics & Heredity
GA AT0UR
UT WOS:000344650700080
PM 25329162
ER

PT J
AU Stumpf, JD
   Copeland, WC
AF Stumpf, Jeffrey D.
   Copeland, William C.
TI MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of
   Replication-Defective Disease-Associated DNA Polymerase gamma Variants
SO PLOS GENETICS
LA English
DT Article
ID PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; YEAST MITOCHONDRIAL-DNA; BASE
   EXCISION-REPAIR; SACCHAROMYCES-CEREVISIAE; MISMATCH REPAIR; EXONUCLEASE
   ACTIVITY; CATALYTIC SUBUNIT; OXIDATIVE STRESS; MUTATOR MICE; MUTATIONS
AB Mitochondrial DNA (mtDNA) encodes proteins essential for ATP production. Mutant variants of the mtDNA polymerase cause mutagenesis that contributes to aging, genetic diseases, and sensitivity to environmental agents. We interrogated mtDNA replication in Saccharomyces cerevisiae strains with disease-associated mutations affecting conserved regions of the mtDNA polymerase, Mip1, in the presence of the wild type Mip1. Mutant frequency arising from mtDNA base substitutions that confer erythromycin resistance and deletions between 21-nucleotide direct repeats was determined. Previously, increased mutagenesis was observed in strains encoding mutant variants that were insufficient to maintain mtDNA and that were not expected to reduce polymerase fidelity or exonuclease proofreading. Increased mutagenesis could be explained by mutant variants stalling the replication fork, thereby predisposing the template DNA to irreparable damage that is bypassed with poor fidelity. This hypothesis suggests that the exogenous base-alkylating agent, methyl methanesulfonate (MMS), would further increase mtDNA mutagenesis. Mitochondrial mutagenesis associated with MMS exposure was increased up to 30-fold in mip1 mutants containing disease-associated alterations that affect polymerase activity. Disrupting exonuclease activity of mutant variants was not associated with increased spontaneous mutagenesis compared with exonuclease-proficient alleles, suggesting that most or all of the mtDNA was replicated by wild type Mip1. A novel subset of C to G transversions was responsible for about half of the mutants arising after MMS exposure implicating error-prone bypass of methylated cytosines as the predominant mutational mechanism. Exposure to MMS does not disrupt exonuclease activity that suppresses deletions between 21-nucleotide direct repeats, suggesting the MMS-induce mutagenesis is not explained by inactivated exonuclease activity. Further, trace amounts of CdCl2 inhibit mtDNA replication but suppresses MMS-induced mutagenesis. These results suggest a novel mechanism wherein mutations that lead to hypermutation by DNA base-damaging agents and associate with mitochondrial disease may contribute to previously unexplained phenomena, such as the wide variation of age of disease onset and acquired mitochondrial toxicities.
C1 [Stumpf, Jeffrey D.; Copeland, William C.] NIEHS, Mitochondrial DNA Replicat Grp, Mol Genet Lab, NIH,DHHS, Res Triangle Pk, NC 27709 USA.
RP Stumpf, JD (reprint author), NIEHS, Mitochondrial DNA Replicat Grp, Mol Genet Lab, NIH,DHHS, POB 12233, Res Triangle Pk, NC 27709 USA.
EM copelan1@niehs.nih.gov
FU National Institute of Environmental Health Sciences, National Institute
   of Health [ES-065078]
FX This work was supported by intramural funds from the National Institute
   of Environmental Health Sciences, National Institute of Health
   (ES-065078). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
NR 55
TC 12
Z9 12
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD OCT
PY 2014
VL 10
IS 10
AR e1004748
DI 10.1371/journal.pgen.1004748
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA AT0UR
UT WOS:000344650700100
PM 25340760
ER

PT J
AU Buddhari, D
   Aldstadt, J
   Endy, TP
   Srikiatkhachorn, A
   Thaisomboonsuk, B
   Klungthong, C
   Nisalak, A
   Khuntirat, B
   Jarman, RG
   Fernandez, S
   Thomas, SJ
   Scott, TW
   Rothman, AL
   Yoon, IK
AF Buddhari, Darunee
   Aldstadt, Jared
   Endy, Timothy P.
   Srikiatkhachorn, Anon
   Thaisomboonsuk, Butsaya
   Klungthong, Chonticha
   Nisalak, Ananda
   Khuntirat, Benjawan
   Jarman, Richard G.
   Fernandez, Stefan
   Thomas, Stephen J.
   Scott, Thomas W.
   Rothman, Alan L.
   Yoon, In-Kyu
TI Dengue Virus Neutralizing Antibody Levels Associated with Protection
   from Infection in Thai Cluster Studies
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; MOLECULAR-BIOLOGY; ENVELOPE
   PROTEIN; TIME-INTERVAL; T-CELLS; VILLAGES; COHORT; TRANSMISSION;
   CHILDREN
AB Background: Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection.
   Methodology/Principal Findings: Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004-2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study (2009-2012), clusters of 200-meter radius were triggered by DENV-infected index cases admitted to the provincial hospital. Subjects of any age >= 6 months were evaluated for DENV infection at days 0 and 14. In both studies, subjects who were DENV PCR positive at day 14/15 were considered to have been "susceptible'' on day 0. Comparison subjects from houses in which someone had documented DENV infection, but the subject remained DENV negative at days 0 and 14/15, were considered "non-susceptible.'' Day 0 samples were presumed to be from just before virus exposure, and underwent plaque reduction neutralization testing (PRNT). Seventeen "susceptible'' (six DENV-1, five DENV-2, and six DENV-4), and 32 "non-susceptible'' (13 exposed to DENV-1, 10 DENV-2, and 9 DENV-4) subjects were evaluated. Comparing subjects exposed to the same serotype, receiver operating characteristic (ROC) curves identified homotypic PRNT titers of 11, 323 and 16 for DENV-1, -2 and -4, respectively, to differentiate "susceptible'' from "non-susceptible'' subjects.
   Conclusions/Significance: PRNT titers were associated with protection from infection by DENV-1, -2 and -4. Protective NTs appeared to be serotype-dependent and may be higher for DENV-2 than other serotypes. These findings are relevant for both dengue epidemiology studies and vaccine development efforts.
C1 [Buddhari, Darunee; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Nisalak, Ananda; Khuntirat, Benjawan; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
   [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA.
   [Endy, Timothy P.] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA.
   [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA.
   [Jarman, Richard G.; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
   [Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA.
   [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA.
RP Buddhari, D (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
EM daruneet@afrims.org
RI Aldstadt, Jared/A-8508-2009
OI Aldstadt, Jared/0000-0001-9162-7439
FU National Institutes of Health [P01 AI34533, R01 GM083224]; U.S. Military
   Infectious Diseases Research Program [S0016-04-AF]; Bill & Melinda Gates
   Foundation Global Health Program [OPP52250]
FX This research was funded, in part, by the National Institutes of Health
   (grants P01 AI34533 and R01 GM083224); the U.S. Military Infectious
   Diseases Research Program (grant S0016-04-AF); The Bill & Melinda Gates
   Foundation Global Health Program (grant OPP52250). The funding source
   had no role in the study design, data collection, analysis and
   interpretation, manuscript writing, or manuscript submission for
   publication.
NR 37
TC 19
Z9 19
U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2014
VL 8
IS 10
AR e3230
DI 10.1371/journal.pntd.0003230
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AS9WJ
UT WOS:000344589000046
PM 25329173
ER

PT J
AU Kumar, R
   Singh, N
   Gautam, S
   Singh, OP
   Gidwani, K
   Rai, M
   Sacks, D
   Sundar, S
   Nylen, S
AF Kumar, Rajiv
   Singh, Neetu
   Gautam, Shalini
   Singh, Om Prakash
   Gidwani, Kamlesh
   Rai, Madhukar
   Sacks, David
   Sundar, Shyam
   Nylen, Susanne
TI Leishmania Specific CD4 T Cells Release IFN gamma That Limits Parasite
   Replication in Patients with Visceral Leishmaniasis
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID INDIAN KALA-AZAR; INTERFERON-GAMMA; INFECTION; INTERLEUKIN-4;
   GENERATION; CYTOKINES; IMMUNITY; DISTINCT; SUBSETS; DISEASE
AB Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFN gamma, and TNF alpha, and elevated expression of IFN gamma mRNA in lesional tissue such as the spleen and bone marrow. However, an immunological feature of VL patients is that their peripheral blood mononuclear cells (PBMCs) typically fail to respond to stimulation with leishmanial antigen. Unexpectedly, it was recently shown that Leishmania specific IFN gamma, can readily be detected when a whole blood stimulation assay (WBA) is used. We sought to define the conditions that permit whole blood cells to respond to antigen stimulation, and clarify the biological role of the IFN gamma found to be released by cells from VL patients. CD4+ T cells were found to be crucial for and the main source of the IFN gamma production in Leishmania stimulated whole blood (WB) cultures. Complement, antibodies and red blood cells present in whole blood do not play a significant role in the IFN gamma response. The IFN gamma production was reduced by blockade of human leukocyte antigen (HLA)-DR, indicating that the response to leishmanial antigens observed in WB of active VL patients is a classical HLA-T cell receptor (TCR) driven reaction. Most importantly, blockade of IFN gamma in ex-vivo splenic aspirate cultures demonstrated that despite the progressive nature of their disease, the endogenous IFN gamma produced in patients with active VL serves to limit parasite growth.
C1 [Kumar, Rajiv; Singh, Neetu; Gautam, Shalini; Singh, Om Prakash; Gidwani, Kamlesh; Rai, Madhukar; Sundar, Shyam] Banaras Hindu Univ, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India.
   [Kumar, Rajiv] Queensland Inst Med Res, Dept Immunol & Infect, Herston, Qld 4006, Australia.
   [Gidwani, Kamlesh] Univ Turku, Dept Biotechnol, Turku, Finland.
   [Sacks, David] NIAID, NIH, Bethesda, MD 20892 USA.
   [Nylen, Susanne] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
RP Kumar, R (reprint author), Banaras Hindu Univ, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India.
EM drshyamsundar@hotmail.com; susanne.nylen@ki.se
OI Nylen, Susanne/0000-0002-3875-3353; Kumar, Rajiv/0000-0003-2338-1494
FU National Institute of Allergy and Infectious Diseases (NIAID), National
   Institutes of Health, Tropical Medicine Research Centers [2P50AI074321];
   Indian Council of Medical Research; University Grants Commission, New
   Delhi; CSIR, New Delhi; Swedish Research Council; National Institute of
   Allergy and Infectious Diseases, National Institutes of Health; Sitaram
   Memorial Trust, KAMRC, Muzaffarpur, Bihar, India
FX This work was funded by the Extramural Program of the National Institute
   of Allergy and Infectious Diseases (NIAID), National Institutes of
   Health, Tropical Medicine Research Centers [2P50AI074321]. RK and SG
   were funded by the Indian Council of Medical Research. NS was funded by
   University Grants Commission, New Delhi, OPS was funded by CSIR, New
   Delhi and SN by the Swedish Research Council. DS was supported by the
   Intramural Research Program of the National Institute of Allergy and
   Infectious Diseases, National Institutes of Health. The care of patients
   was supported by the Sitaram Memorial Trust, KAMRC, Muzaffarpur, Bihar,
   India. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
NR 25
TC 13
Z9 13
U1 3
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2014
VL 8
IS 10
AR e3198
DI 10.1371/journal.pntd.0003198
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AS9WJ
UT WOS:000344589000019
PM 25275531
ER

PT J
AU Tomashek, KM
   Biggerstaff, BJ
   Ramos, MM
   Perez-Guerra, CL
   Rivera, EJG
   Sun, W
AF Tomashek, Kay M.
   Biggerstaff, Brad J.
   Ramos, Mary M.
   Perez-Guerra, Carmen L.
   Rivera, Enid J. Garcia
   Sun, Wellington
TI Physician Survey to Determine How Dengue Is Diagnosed, Treated and
   Reported in Puerto Rico
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID PLATELET TRANSFUSION; CONTROLLED-TRIAL; FEVER; DEATHS; RATES; CARE
AB Dengue is a major cause of morbidity in Puerto Rico and is well-known to its physicians. Early case identification and timely initiation of treatment for patients with severe dengue can reduce medical complications and mortality. To determine clinical management and reporting practices, and assess knowledge of dengue and its management, a survey was sent to 2,512 physicians with a medical license in Puerto Rico. Of the 2,313 physicians who received the survey, 817 (35%) completed the questionnaire. Of the respondents, 708 were currently practicing medicine; 138 were board certified (Group 1), 282 were board eligible (Group 2), and 288 had not finished residency (Group 3). Although respondents clinically diagnosed, on average, 12 cases of dengue in the preceding three months, 31% did not report any suspected cases to public health officials while about half (56%) reported all cases. Overall, 29% of respondents correctly identified early signs of shock and 48% identified severe abdominal pain and persistent vomiting as warning signs for severe dengue with the proportion of correct respondents highest in Group 1. Reportedly about sixty percent (57%) appropriately never give corticosteroids or prophylactic platelet transfusions to dengue patients. One third (30%) of respondents correctly identified administration of intravenous colloid solution as the best treatment option for dengue patients with refractory shock and elevated hematocrit after an initial trial of intravenous crystalloids, and nearly one half (46%) correctly identified administration of a blood transfusion as the best option for dengue patients with refractory shock and decreased hematocrit after a trial of intravenous crystalloids. Even though dengue has been endemic in Puerto Rico for nearly 4 decades, knowledge of dengue management is still limited, compliance with WHO treatment guidelines is suboptimal, and underreporting is significant. These findings were used to design a post graduate training course to improve the clinical management of dengue.
C1 [Tomashek, Kay M.; Ramos, Mary M.; Perez-Guerra, Carmen L.; Sun, Wellington] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, San Juan, PR USA.
   [Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO USA.
   [Rivera, Enid J. Garcia] Puerto Rico Dept Hlth, San Juan, PR USA.
RP Tomashek, KM (reprint author), NIAID, OCRR, DMID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM kay.tomashek@nih.gov
NR 37
TC 4
Z9 4
U1 1
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2014
VL 8
IS 10
AR e3192
DI 10.1371/journal.pntd.0003192
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AS9WJ
UT WOS:000344589000016
PM 25299251
ER

PT J
AU Wilson, AL
   Dhiman, RC
   Kitron, U
   Scott, TW
   van den Berg, H
   Lindsay, SW
AF Wilson, Anne L.
   Dhiman, Ramesh C.
   Kitron, Uriel
   Scott, Thomas W.
   van den Berg, Henk
   Lindsay, Steven W.
TI Benefit of Insecticide-Treated Nets, Curtains and Screening on Vector
   Borne Diseases, Excluding Malaria: A Systematic Review and Meta-analysis
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID CLUSTER-RANDOMIZED-TRIAL; PAPUA-NEW-GUINEA;
   LAMBDACYHALOTHRIN-IMPREGNATED BEDNETS; VISCERAL LEISHMANIASIS; CUTANEOUS
   LEISHMANIASIS; LYMPHATIC FILARIASIS; AEDES-AEGYPTI; BED NETS; DENGUE
   VECTORS; PHLEBOTOMINE SANDFLIES
AB Introduction: Insecticide-treated nets (ITNs) are one of the main interventions used for malaria control. However, these nets may also be effective against other vector borne diseases (VBDs). We conducted a systematic review and meta-analysis to estimate the efficacy of ITNs, insecticide-treated curtains (ITCs) and insecticide-treated house screening (ITS) against Chagas disease, cutaneous and visceral leishmaniasis, dengue, human African trypanosomiasis, Japanese encephalitis, lymphatic filariasis and onchocerciasis.
   Methods: MEDLINE, EMBASE, LILACS and Tropical Disease Bulletin databases were searched using intervention, vector-and disease-specific search terms. Cluster or individually randomised controlled trials, non-randomised trials with pre- and post-intervention data and rotational design studies were included. Analysis assessed the efficacy of ITNs, ITCs or ITS versus no intervention. Meta-analysis of clinical data was performed and percentage reduction in vector density calculated.
   Results: Twenty-one studies were identified which met the inclusion criteria. Meta-analysis of clinical data could only be performed for four cutaneous leishmaniasis studies which together showed a protective efficacy of ITNs of 77% (95% CI: 39%-91%). Studies of ITC and ITS against cutaneous leishmaniasis also reported significant reductions in disease incidence. Single studies reported a high protective efficacy of ITS against dengue and ITNs against Japanese encephalitis. No studies of Chagas disease, human African trypanosomiasis or onchocerciasis were identified.
   Conclusion: There are likely to be considerable collateral benefits of ITN roll out on cutaneous leishmaniasis where this disease is co-endemic with malaria. Due to the low number of studies identified, issues with reporting of entomological outcomes, and few studies reporting clinical outcomes, it is difficult to make strong conclusions on the effect of ITNs, ITCs or ITS on other VBDs and therefore further studies be conducted. Nonetheless, it is clear that insecticide-treated materials such as ITNs have the potential to reduce pathogen transmission and morbidity from VBDs where vectors enter houses.
C1 [Wilson, Anne L.; Lindsay, Steven W.] Univ Durham, Sch Biol & Biomed Sci, Durham, England.
   [Dhiman, Ramesh C.] Natl Inst Malaria Res ICMR, New Delhi, India.
   [Kitron, Uriel] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA.
   [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA.
   [van den Berg, Henk] Wageningen Univ, Entomol Lab, NL-6700 AP Wageningen, Netherlands.
RP Wilson, AL (reprint author), Univ Durham, Sch Biol & Biomed Sci, Stockton Rd, Durham, England.
EM s.w.lindsay@durham.ac.uk
FU Bill & Melinda Gates Foundation [OPP1053338]
FX This work was supported by a grant from The Bill & Melinda Gates
   Foundation (OPP1053338, SWL, ALW, RCD, UK, TWS, HvdB). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
NR 80
TC 16
Z9 16
U1 1
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2014
VL 8
IS 10
AR e3228
DI 10.1371/journal.pntd.0003228
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AS9WJ
UT WOS:000344589000045
PM 25299481
ER

PT J
AU Andrade, BB
   Singh, A
   Narendran, G
   Schechter, ME
   Nayak, K
   Subramanian, S
   Anbalagan, S
   Jensen, SMR
   Porter, BO
   Antonelli, LR
   Wilkinson, KA
   Wilkinson, RJ
   Meintjes, G
   van der Plas, H
   Follmann, D
   Barber, DL
   Swaminathan, S
   Sher, A
   Sereti, I
AF Andrade, Bruno B.
   Singh, Amrit
   Narendran, Gopalan
   Schechter, Melissa E.
   Nayak, Kaustuv
   Subramanian, Sudha
   Anbalagan, Selvaraj
   Jensen, Stig M. R.
   Porter, Brian O.
   Antonelli, Lis R.
   Wilkinson, Katalin A.
   Wilkinson, Robert J.
   Meintjes, Graeme
   van der Plas, Helen
   Follmann, Dean
   Barber, Daniel L.
   Swaminathan, Soumya
   Sher, Alan
   Sereti, Irini
TI Mycobacterial Antigen Driven Activation of CD14(++) CD16(-) Monocytes Is
   a Predictor of Tuberculosis-Associated Immune Reconstitution
   Inflammatory Syndrome
SO PLOS PATHOGENS
LA English
DT Article
ID RESOURCE-LIMITED SETTINGS; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; LIFE
   EXPECTANCY; HIV-INFECTION; DISEASE; PATHOGENESIS; INDIVIDUALS;
   COINFECTION; INITIATION
AB Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response occurring in a subset of TB-HIV co-infected patients initiating anti-retroviral therapy (ART). Here, we examined monocyte activation by prospectively quantitating pro-inflammatory plasma markers and monocyte subsets in TB-HIV co-infected patients from a South Indian cohort at baseline and following ART initiation at the time of IRIS, or at equivalent time points in non-IRIS controls. Pro-inflammatory biomarkers of innate and myeloid cell activation were increased in plasma of IRIS patients pre-ART and at the time of IRIS; this association was confirmed in a second cohort in South Africa. Increased expression of these markers correlated with elevated antigen load as measured by higher sputum culture grade and shorter duration of anti-TB therapy. Phenotypic analysis revealed the frequency of CD14(++) CD16(-) monocytes was an independent predictor of TB-IRIS, and was closely associated with plasma levels of CRP, TNF, IL-6 and tissue factor during IRIS. In addition, production of inflammatory cytokines by monocytes was higher in IRIS patients compared to controls pre-ART. These data point to a major role of mycobacterial antigen load and myeloid cell hyperactivation in the pathogenesis of TB-IRIS, and implicate monocytes and monocyte-derived cytokines as potential targets for TB-IRIS prevention or treatment.
C1 [Andrade, Bruno B.; Sher, Alan] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
   [Singh, Amrit; Schechter, Melissa E.; Jensen, Stig M. R.; Porter, Brian O.; Sereti, Irini] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
   [Narendran, Gopalan; Nayak, Kaustuv; Subramanian, Sudha; Anbalagan, Selvaraj; Swaminathan, Soumya] Natl Inst Res TB, Madras, Tamil Nadu, India.
   [Antonelli, Lis R.] Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Imunopatol, Belo Horizonte, MG, Brazil.
   [Wilkinson, Katalin A.; Wilkinson, Robert J.; Meintjes, Graeme; van der Plas, Helen] Univ Cape Town, Clin Infect Dis Res Initiat, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa.
   [Wilkinson, Katalin A.; Wilkinson, Robert J.; Meintjes, Graeme; van der Plas, Helen] Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa.
   [Wilkinson, Robert J.; Meintjes, Graeme] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.
   [Wilkinson, Robert J.] MRC Natl Inst Med Res, London, England.
   [Follmann, Dean] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA.
   [Barber, Daniel L.] NIAID, T Lymphocyte Biol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Andrade, BB (reprint author), NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM andradebd@naid.nih.gov; isereti@niaid.nih.gov
RI Andrade, Bruno/J-9111-2012
OI Andrade, Bruno/0000-0001-6833-3811
FU Intramural Research Program of NIAID/NIH; Wellcome Trust [098316,
   084323, 088316]; National Institute of Allergy and Infectious Diseases
   [U01 AI089244]; EDCTP Strategic Primer Grant [SP.2011.41304.074]; South
   African Department of Science and Technology; National Research
   Foundation (NRF) of South Africa [UID: 85858]; NRF; Medical Research
   Council [U1175.02.002.00014.01]; European Union [PIRSES-GA-2011-295214];
    [DST/CON 0257/2012]
FX This study was supported in part by the Intramural Research Program of
   NIAID/NIH. GM was supported by a Wellcome Trust fellowship (098316), a
   National Institute of Allergy and Infectious Diseases grant (U01
   AI089244), an EDCTP Strategic Primer Grant (SP.2011.41304.074), South
   African Department of Science and Technology co-funding (DST/CON
   0257/2012), and in part by the National Research Foundation (NRF) of
   South Africa (UID: 85858). The grant-holder acknowledges that the
   opinions, findings, conclusions, and recommendations expressed in any
   publication generated by NRF-supported research are those of the
   author(s), and that the NRF accepts no liability whatsoever in this
   regard. RJW receives support from the Wellcome Trust (084323, 088316),
   from the Medical Research Council (U1175.02.002.00014.01) and European
   Union (PIRSES-GA-2011-295214). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 48
TC 25
Z9 25
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004433
DI 10.1371/journal.ppat.1004433
PG 16
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800030
PM 25275318
ER

PT J
AU Bertuzzi, M
   Schrettl, M
   Alcazar-Fuoli, L
   Cairns, TC
   Munoz, A
   Walker, LA
   Herbst, S
   Safari, M
   Cheverton, AM
   Chen, D
   Liu, H
   Saijo, S
   Fedorova, ND
   Armstrong-James, D
   Munro, CA
   Read, ND
   Filler, SG
   Espeso, EA
   Nierman, WC
   Haas, H
   Bignell, EM
AF Bertuzzi, Margherita
   Schrettl, Markus
   Alcazar-Fuoli, Laura
   Cairns, Timothy C.
   Munoz, Alberto
   Walker, Louise A.
   Herbst, Susanne
   Safari, Maryam
   Cheverton, Angela M.
   Chen, Dan
   Liu, Hong
   Saijo, Shinobu
   Fedorova, Natalie D.
   Armstrong-James, Darius
   Munro, Carol A.
   Read, Nick D.
   Filler, Scott G.
   Espeso, Eduardo A.
   Nierman, William C.
   Haas, Hubertus
   Bignell, Elaine M.
TI The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus
   Governs Epithelial Entry and Tissue Invasion during Pulmonary
   Aspergillosis
SO PLOS PATHOGENS
LA English
DT Article
ID SURVEILLANCE NETWORK TRANSNET; HEMATOPOIETIC STEM-CELL; BETA-GLUCAN
   RECEPTOR; CANDIDA-ALBICANS; AMBIENT-PH; TRANSPLANT RECIPIENTS;
   FUNCTIONAL-ANALYSIS; IMMUNE RECOGNITION; ALKALINE PROTEASE;
   ENDOTHELIAL-CELLS
AB Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking individual or multiple enzymes remain fully invasive, suggesting a concomitant requirement for other pathogenic activities during host invasion. In this study we discovered, and exploited, a novel, tissue non-invasive, phenotype in A. fumigatus mutants lacking the pH-responsive transcription factor PacC. Our study revealed a novel mode of epithelial entry, occurring in a cell wall-dependent manner prior to protease production, and via the Dectin-1 beta-glucan receptor. Delta pacC mutants are defective in both contact-mediated epithelial entry and protease expression, and significantly attenuated for pathogenicity in leukopenic mice. We combined murine infection modelling, in vivo transcriptomics, and in vitro infections of human alveolar epithelia, to delineate two major, and sequentially acting, PacC-dependent processes impacting epithelial integrity in vitro and tissue invasion in the whole animal. We demonstrate that A. fumigatus spores and germlings are internalised by epithelial cells in a contact-, actin-, cell wall- and Dectin-1 dependent manner and Delta pacC mutants, which aberrantly remodel the cell wall during germinative growth, are unable to gain entry into epithelial cells, both in vitro and in vivo. We further show that PacC acts as a global transcriptional regulator of secreted molecules during growth in the leukopenic mammalian lung, and profile the full cohort of secreted gene products expressed during invasive infection. Our study reveals a combinatorial mode of tissue entry dependent upon sequential, and mechanistically distinct, perturbations of the pulmonary epithelium and demonstrates, for the first time a protective role for Dectin-1 blockade in epithelial defences. Infecting Delta pacC mutants are hypersensitive to cell wall-active antifungal agents highlighting the value of PacC signalling as a target for antifungal therapy.
C1 [Bertuzzi, Margherita; Munoz, Alberto; Safari, Maryam; Read, Nick D.; Bignell, Elaine M.] Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, England.
   [Schrettl, Markus; Haas, Hubertus] Med Univ Innsbruck, Bioctr, Div Mol Biol, A-6020 Innsbruck, Austria.
   [Schrettl, Markus] Sandoz GmbH, Kundl, Austria.
   [Alcazar-Fuoli, Laura] Inst Salud Carlos III, Natl Ctr Microbiol, Madrid, Spain.
   [Cairns, Timothy C.] Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England.
   [Walker, Louise A.; Munro, Carol A.] Univ Aberdeen, Sch Med Sci, Aberdeen, Scotland.
   [Herbst, Susanne; Cheverton, Angela M.; Armstrong-James, Darius] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Bacteriol & Infect, London, England.
   [Chen, Dan; Fedorova, Natalie D.; Nierman, William C.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
   [Liu, Hong; Filler, Scott G.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles Biomed Res Inst Harbor, Med Ctr, Los Angeles, CA 90095 USA.
   [Saijo, Shinobu] Chiba Univ, Med Mycol Res Ctr, Chiba, Japan.
   [Espeso, Eduardo A.] Ctr Invest Biol CSIC, Dept Mol & Cellular Biol, Madrid, Spain.
RP Bignell, EM (reprint author), Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, England.
EM elaine.bignell@manchester.ac.uk
RI Espeso, Eduardo /C-5259-2011; 
OI Espeso, Eduardo /0000-0002-5873-6059; Read, Nick/0000-0002-2286-2862;
   Cairns, Timothy/0000-0001-7106-224X
FU MRC [G0501164]; BBSRC [BB/G009619/1]; Wellcome Trust [WT093596MA];
   Imperial College London (Division of Investigative Sciences PhD
   Studentship); ERA-NET PathoGenoMics project TRANSPAT, Austrian Science
   Foundation [FWF I282-B09]; National Institutes of Health, USA
   [R01AI073829]
FX This work was supported in part by grants to EMB from the MRC (G0501164)
   and BBSRC (BB/G009619/1), to EMB and NDR from the Wellcome Trust
   (WT093596MA), to MB from Imperial College London (Division of
   Investigative Sciences PhD Studentship), to HH from the ERA-NET
   PathoGenoMics project TRANSPAT, Austrian Science Foundation (FWF
   I282-B09), to SGF from the National Institutes of Health, USA
   (R01AI073829). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
NR 85
TC 21
Z9 22
U1 2
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004413
DI 10.1371/journal.ppat.1004413
PG 20
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800016
PM 25329394
ER

PT J
AU Blumberg, S
   Funk, S
   Pulliam, JRC
AF Blumberg, Seth
   Funk, Sebastian
   Pulliam, Juliet R. C.
TI Detecting Differential Transmissibilities That Affect the Size of
   Self-Limited Outbreaks
SO PLOS PATHOGENS
LA English
DT Article
ID ACUTE RESPIRATORY SYNDROME; UNITED-STATES; INFECTIOUS-DISEASES;
   REEMERGING PATHOGENS; MEASLES ELIMINATION; HUMAN MONKEYPOX;
   RISK-FACTORS; SURVEILLANCE; EMERGENCE; EPIDEMIC
AB Our ability to respond appropriately to infectious diseases is enhanced by identifying differences in the potential for transmitting infection between individuals. Here, we identify epidemiological traits of self-limited infections (i.e. infections with an effective reproduction number satisfying 0 <R-eff <1) that correlate with transmissibility. Our analysis is based on a branching process model that permits statistical comparison of both the strength and heterogeneity of transmission for two distinct types of cases. Our approach provides insight into a variety of scenarios, including the transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the Arabian peninsula, measles in North America, pre-eradication smallpox in Europe, and human monkeypox in the Democratic Republic of the Congo. When applied to chain size data for MERS-CoV transmission before 2014, our method indicates that despite an apparent trend towards improved control, there is not enough statistical evidence to indicate that R-eff has declined with time. Meanwhile, chain size data for measles in the United States and Canada reveal statistically significant geographic variation in R-eff, suggesting that the timing and coverage of national vaccination programs, as well as contact tracing procedures, may shape the size distribution of observed infection clusters. Infection source data for smallpox suggests that primary cases transmitted more than secondary cases, and provides a quantitative assessment of the effectiveness of control interventions. Human monkeypox, on the other hand, does not show evidence of differential transmission between animals in contact with humans, primary cases, or secondary cases, which assuages the concern that social mixing can amplify transmission by secondary cases. Lastly, we evaluate surveillance requirements for detecting a change in the human-to-human transmission of monkeypox since the cessation of cross-protective smallpox vaccination. Our studies lay the foundation for future investigations regarding how infection source, vaccination status or other putative transmissibility traits may affect self-limited transmission.
C1 [Blumberg, Seth] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA.
   [Blumberg, Seth; Pulliam, Juliet R. C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Funk, Sebastian] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London WC1, England.
   [Funk, Sebastian] Princeton Univ, Princeton, NJ 08544 USA.
   [Pulliam, Juliet R. C.] Univ Florida, Dept Biol, Gainesville, FL USA.
   [Pulliam, Juliet R. C.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA.
RP Blumberg, S (reprint author), Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA.
EM seth.blumberg@ucsf.edu
RI Pulliam, Juliet/A-6516-2008; 
OI Pulliam, Juliet/0000-0003-3314-8223; Funk, Sebastian/0000-0002-2842-3406
FU National Institute of Health MIDAS program [NIH NIGMS 1-U01-GM087728];
   RAPIDD program of the Science and Technology Directorate, Department of
   Homeland Security; National Institute of Health, Fogarty International
   Center; Royal Society International Exchanges grant; Medical Research
   Council Career Development Award in Biostatistics; John S. McDonnell
   Foundation; National Science Foundation; U.S. Department of Homeland
   Security; U.S. Department of Agriculture through NSF [EF-0832858,
   DBI-1300426]; University of Tennessee, Knoxville; Banff International
   Research Station; Isaac Newton Institute for Mathematical Sciences
FX This work was supported by the National Institute of Health MIDAS
   program (Modeling Infectious Disease Agent Study) [grant number NIH
   NIGMS 1-U01-GM087728 to SB]; the RAPIDD program of the Science and
   Technology Directorate, Department of Homeland Security (Research and
   Policy for Infectious Disease Dynamics) [to SB and JRCP]; the National
   Institute of Health, Fogarty International Center [to SB and JP]; a
   Royal Society International Exchanges grant [to SF and SB]; a Medical
   Research Council Career Development Award in Biostatistics [to SF]; and
   the John S. McDonnell Foundation [to SF]. This work was also assisted
   through participation in the 'modeling wildlife and virus zoonoses'
   investigative workshop (November 2010) at the National Institute for
   Mathematical and Biological Synthesis, sponsored by the National Science
   Foundation, the U.S. Department of Homeland Security, and the U.S.
   Department of Agriculture through NSF Awards EF-0832858 and DBI-1300426,
   with additional support from The University of Tennessee, Knoxville [SB,
   SF and JRCP]; the 'modeling and analysis of options for controlling
   persistent infectious diseases' workshop (February, 2011) at the Banff
   International Research Station [SB and SF]; and the 'infectious disease
   dynamics' workshop (August 2013) at Isaac Newton Institute for
   Mathematical Sciences [SF and JRCP]. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 65
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U1 3
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004452
DI 10.1371/journal.ppat.1004452
PG 14
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800043
PM 25356657
ER

PT J
AU Dalziel, BD
   Huang, K
   Geoghegan, JL
   Arinaminpathy, N
   Dubovi, EJ
   Grenfell, BT
   Ellner, SP
   Holmes, EC
   Parrish, CR
AF Dalziel, Benjamin D.
   Huang, Kai
   Geoghegan, Jemma L.
   Arinaminpathy, Nimalan
   Dubovi, Edward J.
   Grenfell, Bryan T.
   Ellner, Stephen P.
   Holmes, Edward C.
   Parrish, Colin R.
TI Contact Heterogeneity, Rather Than Transmission Efficiency, Limits the
   Emergence and Spread of Canine Influenza Virus
SO PLOS PATHOGENS
LA English
DT Article
ID INFECTIOUS-DISEASES; A VIRUSES; DOGS; H3N8; EVOLUTION; EPIDEMIC;
   DYNAMICS; ORIGINS; SEROPREVALENCE; CHINA
AB Host-range shifts in influenza virus are a major risk factor for pandemics. A key question in the study of emerging zoonoses is how the evolution of transmission efficiency interacts with heterogeneity in contact patterns in the new host species, as this intery influences disease dynamics and prospects for control. Here we use a synergistic of models and data part the evolutionary and demographic processes controlling a host-range h(-1) equine H3N8-derived canine influenza virus (CIV). CIV has experienced 15 years of continuous transfer among dogs in the United States, bLit maintain patchy distribution, characterized by sporadic short-lived outbreaks coupled with endemic hotspots in large animal shelte how that CIV has ig reproductive potential in these f (mean Ro = 9) and that these hotspots act as refug from he sparsely connected majority of the dog population. Intriguingly, CIV has volved a transmission efficiency that closely matches the minimum required to persist in these refugia, leaving it poised on the extinction/invasion threshold of the host contact network. Corresponding phylogenetic analyses show strong geographic clustering in three US regions, and that the effective reproductive number of the virus (Re) in the general dog population is close to 1.0. Our results highlight the critical role of host contact structure in CIV dynamics and show how host contact networks could shape the evolution of pathogen transmission efficiency. Importantly, efficient control measures could eradicate the virLis, in turn minimizing the risk of future sustained transmission among companion dogs that could represent a potential new axis to the human interface for influenza.
C1 [Dalziel, Benjamin D.; Arinaminpathy, Nimalan; Grenfell, Bryan T.; Ellner, Stephen P.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA.
   [Huang, Kai; Parrish, Colin R.] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, Ithaca, NY 14853 USA.
   [Geoghegan, Jemma L.; Holmes, Edward C.] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Charles Perkins Ctr, Sch Biol Sci, Sydney, NSW 2006, Australia.
   [Geoghegan, Jemma L.; Holmes, Edward C.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Arinaminpathy, Nimalan] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Infect Dis Epidemiol, London, England.
   [Dubovi, Edward J.] Cornell Univ, Coll Vet Med, Dept Populat Med & Diagnost Sci, Ithaca, NY 14853 USA.
   [Grenfell, Bryan T.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Dalziel, BD (reprint author), Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA.
EM bdd36@cornell.edu
OI Dalziel, Benjamin/0000-0002-9674-2783; Holmes,
   Edward/0000-0001-9596-3552
FU NIH/NIGMS [2 R01 GM080533]; NHMRC Australia; RAPIDD program of the
   Science & Technology Directorate, Department of Homeland Security;
   Fogarty International Center, National Institutes of Health; DHS
   [HSHQDC-12-C-00058]
FX This work was supported by NIH/NIGMS grant 2 R01 GM080533 to CRP and
   ECH. ECH was supported by an NHMRC Australia Fellowship. BTG was
   supported by the RAPIDD program of the Science & Technology Directorate,
   Department of Homeland Security, and the Fogarty International Center,
   National Institutes of Health and DHS contract HSHQDC-12-C-00058. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
NR 55
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U1 4
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004455
DI 10.1371/journal.ppat.1004455
PG 13
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800045
PM 25340642
ER

PT J
AU Micci, L
   Alvarez, X
   Iriele, RI
   Ortiz, AM
   Ryan, ES
   McGary, CS
   Deleage, C
   McAtee, BB
   He, TY
   Apetrei, C
   Easley, K
   Pahwa, S
   Collman, RG
   Derdeyn, CA
   Davenport, MP
   Estes, JD
   Silvestri, G
   Lackner, AA
   Paiardini, M
AF Micci, Luca
   Alvarez, Xavier
   Iriele, Robin I.
   Ortiz, Alexandra M.
   Ryan, Emily S.
   McGary, Colleen S.
   Deleage, Claire
   McAtee, Brigitte B.
   He, Tianyu
   Apetrei, Cristian
   Easley, Kirk
   Pahwa, Savita
   Collman, Ronald G.
   Derdeyn, Cynthia A.
   Davenport, Miles P.
   Estes, Jacob D.
   Silvestri, Guido
   Lackner, Andrew A.
   Paiardini, Mirko
TI CD4 Depletion in SIV-Infected Macaques Results in Macrophage and
   Microglia Infection with Rapid Turnover of Infected Cells
SO PLOS PATHOGENS
LA English
DT Article
ID SIMIAN-IMMUNODEFICIENCY-VIRUS; T-CELLS; RHESUS MACAQUES; IN-VIVO;
   PERIVASCULAR MACROPHAGES; ANTIRETROVIRAL THERAPY; AIDS PATHOGENESIS;
   NONHUMAN-PRIMATES; VIRAL PERSISTENCE; SOLUBLE CD163
AB In rhesus macaques (RMs), experimental depletion of CD4(+) T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4(+) T-cells prior to SIVmac(251) infection and investigate the sources of the increased viral burden and the lifespan of productively infected cells. CD4-depleted animals showed (i) set-point viral load two-logs higher than controls; (ii) macrophages constituting 80% of all SIV vRNA(+) cells in lymph node and mucosal tissues; (iii) substantial expansion of pro-inflammatory monocytes; (iv) aberrant activation and infection of microglial cells; and (v) lifespan of productively infected cells significantly longer in comparison to controls, but markedly shorter than previously estimated for macrophages. The net effect of CD4(+) T-cell depletion is an inability to control SIV replication and a shift in the tropism of infected cells to macrophages, microglia, and, potentially, other CD4-low cells which all appear to have a shortened in vivo lifespan. We believe these findings have important implications for HIV eradication studies.
C1 [Micci, Luca; Iriele, Robin I.; Ortiz, Alexandra M.; Ryan, Emily S.; McGary, Colleen S.; Silvestri, Guido; Paiardini, Mirko] Emory Univ, Sch Med, Div Microbiol & Immunol, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
   [Alvarez, Xavier; McAtee, Brigitte B.; Lackner, Andrew A.] Tulane Univ, Tulane Natl Primate Res Ctr, Sch Med, Covington, LA USA.
   [Deleage, Claire; Estes, Jacob D.] Leidos Biomed Res Inc, AIDS Canc Virus Program, Frederick Natl Lab Canc Res, Frederick, MD USA.
   [He, Tianyu; Apetrei, Cristian] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA.
   [Easley, Kirk] Rollins Sch Publ Hlth, Dept Biostat & Epidemiol, Atlanta, GA USA.
   [Pahwa, Savita] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Collman, Ronald G.] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Derdeyn, Cynthia A.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA.
   [Derdeyn, Cynthia A.; Silvestri, Guido; Paiardini, Mirko] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
   [Davenport, Miles P.] Univ New S Wales, Ctr Vasc Res, Kensington, NSW 2033, Australia.
RP Micci, L (reprint author), Emory Univ, Sch Med, Div Microbiol & Immunol, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
EM mirko.paiardini@emory.edu
RI Easley, Kirk/K-6910-2015
OI Easley, Kirk/0000-0003-4419-2617
FU National Institute Of Allergy And Infectious Diseases of the National
   Institute of Health [R56AI087186, R01AI084836, OD011132, P30AI50409,
   RR000164/OD011104]; National Cancer Institute, National Institutes of
   Health [HHSN261200800001E]; National Health and Medical Research Council
   (Australia)
FX Research reported in this publication was supported by the National
   Institute Of Allergy And Infectious Diseases of the National Institute
   of Health under Award Numbers R56AI087186 and R01AI084836 (to MP), as
   well as by grant OD011132 (to the Yerkes National Primate Research
   Center), P30AI50409 (to the Emory Center for AIDS Research) and
   RR000164/OD011104 (to Tulane National Primate Research Center). This
   project has been funded in part with federal funds from the National
   Cancer Institute, National Institutes of Health, under Contract No.
   HHSN261200800001E. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institute of Health, nor does mention of trade names,
   commercial products, or organizations imply endorsement by the U.S.
   Government. MPD is supported by the National Health and Medical Research
   Council (Australia). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 40
TC 28
Z9 28
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004467
DI 10.1371/journal.ppat.1004467
PG 13
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800053
PM 25356757
ER

PT J
AU Sato, K
   Takeuchi, JS
   Misawa, N
   Izumi, T
   Kobayashi, T
   Kimura, Y
   Iwami, S
   Takaori-Kondo, A
   Hu, WS
   Aihara, K
   Ito, M
   An, DS
   Pathak, VK
   Koyanagi, Y
AF Sato, Kei
   Takeuchi, Junko S.
   Misawa, Naoko
   Izumi, Taisuke
   Kobayashi, Tomoko
   Kimura, Yuichi
   Iwami, Shingo
   Takaori-Kondo, Akifumi
   Hu, Wei-Shau
   Aihara, Kazuyuki
   Ito, Mamoru
   An, Dong Sung
   Pathak, Vinay K.
   Koyanagi, Yoshio
TI APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and
   Evolution in Humanized Mouse Model
SO PLOS PATHOGENS
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; BLOOD MONONUCLEAR-CELLS;
   REVERSE TRANSCRIPTION; IN-VIVO; RETROVIRAL RESTRICTION; CYTIDINE
   DEAMINATION; PRIMARY LYMPHOCYTES; INTERFERON-ALPHA; A MUTATIONS
AB Several APOBEC3 proteins, particLilarly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutation in HIV-1 enome, and abrogate viral replication in experimental systems, but their relative contributions to controlling eplication and viral genetic variation in vivo have not been elucidated. On the other hand, an HIV-1-encoded protein, Vrf an degrade these APOBEC3 proteins via a ulpiquitiniproteasorne pathway. Although APOBEC3 proteins have been widely considered as potent restriction factors against HIV-1, it remains unclear which endogenous APOBEC3 protein(s) affect HIV-1 propagation in vivo. Here we use a humanized mouse model and HIV-1 with mutations in Vif motifs that are responsible for specific APOBEC3 interactions, DRMR/AAAA (4A) or YRHHY/AAAAA (5A), and demonstrate that endogenous APOBEC3D/F and APOBEC3G exert strong anti-HIV-1 activity in vivo. We also show that the growth kinetics of 4A HIV-1 negatively correlated with the expression level of APOBEC3F. Moreover, single genome sequencing analyses of viral RNA in plasma of nfected mice reveal that 4A HIV-1 is specifically and significantly diversified. Furthermore, a mutated virus that is capable of using both CCR5 and CXCR4 as entry coreceptor is specifically detected in 4A HIV-1-infected mice. Taken together, our ts demonstrate that APOBEC3D/F and APOBEC3G fundamentally work as restriction factors against HIV-1 in vivo but at the same time, that APOBEC3D and APOBEC3F are capable of promoting viral diversification and evolution in vivo.
C1 [Sato, Kei; Takeuchi, Junko S.; Misawa, Naoko; Kobayashi, Tomoko; Kimura, Yuichi; Koyanagi, Yoshio] Kyoto Univ, Inst Virus Res, Lab Viral Pathogenesis, Kyoto 606, Japan.
   [Izumi, Taisuke; Pathak, Vinay K.] NCI, Viral Mutat Sect, HIV Drug Resistance Program, Ctr Canc Res, Frederick, MD 21701 USA.
   [Izumi, Taisuke] Kyushu Univ, Fac Sci, Dept Biol, Fukuoka 812, Japan.
   [Takaori-Kondo, Akifumi] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan.
   [Hu, Wei-Shau] NCI, Viral Recombinat Sect, HIV Drug Resistance Program, Ctr Canc Res, Frederick, MD 21701 USA.
   [Aihara, Kazuyuki] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo, Japan.
   [Aihara, Kazuyuki] Univ Tokyo, Grad Sch Informat Sci & Technol, Meguro Ku, Tokyo, Japan.
   [Ito, Mamoru] Cent Inst Expt Anim, Kawasaki, Kanagawa, Japan.
   [An, Dong Sung] Univ Calif Los Angeles, Div Hematol & Oncol, Los Angeles, CA USA.
   [An, Dong Sung] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA.
   [An, Dong Sung] Univ Calif Los Angeles, AIDS Inst, Los Angeles, CA USA.
RP Sato, K (reprint author), Kyoto Univ, Inst Virus Res, Lab Viral Pathogenesis, Kyoto 606, Japan.
EM ksato@virus.kyoto-u.ac.jp
FU Aihara Innovative Mathematical Modelling Project, JSPS; Council for
   Science and Technology Policy of Japan; Japan Society for the Promotion
   of Science (JSPS) [B24390112, S22220007, B23790500]; Ministry of
   Education, Culture, Sports, Science and Technology of Japan [24115008];
   Ministry of Health, Labor and Welfare of Japan; Takeda Science
   Foundation; Sumitomo Foundation; Senshin Medical Research Foundation;
   Imai Memorial Trust for AIDS Research; JST PRESTO program; UCLA CFAR
   grant [5P30AI028697]; JSPS Research Fellowship for Japanese Biomedical
   and Behavioral Researchers at NIH; Intramural Research Program of the
   NIH, National Cancer Institute, Center for Cancer Research
FX This study was supported in-part by grants from the following: the
   Aihara Innovative Mathematical Modelling Project, JSPS through the
   "Funding Program for World-Leading Innovative R&D on Science and
   Technology (FIRST Program)," initiated by the Council for Science and
   Technology Policy of Japan (to KS, SI, and KA); Grants-in-Aid for
   Scientific Research B24390112 (to YKo) and S22220007 (to MI and YKo) and
   a Grant-in-Aid for Young Scientists B23790500 (to KS) from the Japan
   Society for the Promotion of Science (JSPS); a Grant-in-Aid for
   Scientific Research on Innovative Areas 24115008 (to YKo) from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan,
   Research on HIV/AIDS (to YKo) from the Ministry of Health, Labor and
   Welfare of Japan; Takeda Science Foundation (to KS); Sumitomo Foundation
   Research Grant (to KS); Senshin Medical Research Foundation (to KS);
   Imai Memorial Trust for AIDS Research (to KS); JST PRESTO program (to
   SI); and a UCLA CFAR grant 5P30AI028697 (to DSA); JSPS Research
   Fellowship for Japanese Biomedical and Behavioral Researchers at NIH (to
   TI); and the Intramural Research Program of the NIH, National Cancer
   Institute, Center for Cancer Research (to VKP). The content of this
   publication does not necessarily reflect the views or policies of the
   Department of Health and Human Services, nor does mention of trade
   names, commercial products, or organizations imply endorsement by the
   U.S. Government. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 81
TC 27
Z9 27
U1 2
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2014
VL 10
IS 10
AR e1004453
DI 10.1371/journal.ppat.1004453
PG 15
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AS9FO
UT WOS:000344548800044
PM 25330146
ER

PT J
AU Abar, B
   LaGasse, LL
   Wouldes, T
   Derauf, C
   Newman, E
   Shah, R
   Smith, LM
   Arria, AM
   Huestis, MA
   Della Grotta, S
   Dansereau, LM
   Wilcox, T
   Neal, CR
   Lester, BM
AF Abar, Beau
   LaGasse, Linda L.
   Wouldes, Trecia
   Derauf, Chris
   Newman, Elana
   Shah, Rizwan
   Smith, Lynne M.
   Arria, Amelia M.
   Huestis, Marilyn A.
   Della Grotta, Sheri
   Dansereau, Lynne M.
   Wilcox, Tara
   Neal, Charles R.
   Lester, Barry M.
TI Cross-national Comparison of Prenatal Methamphetamine Exposure on Infant
   and Early Child Physical Growth: A Natural Experiment
SO PREVENTION SCIENCE
LA English
DT Article
DE Prenatal methamphetamine exposure; Length/height; Weight; Cross-national
   research
ID COCAINE EXPOSURE; CAUSAL INFERENCE; LIFE-STYLE; IN-UTERO; BRAIN; AGE;
   AMPHETAMINES; ENVIRONMENT; ABUSE; WOMEN
AB The current study seeks to compare the effects of prenatal methamphetamine exposure (PME) on infant and child physical growth between the USA and New Zealand (NZ). This cross-national comparison provides a unique opportunity to examine the potential impact of services provided to drug using mothers on child health. The longitudinal Infant Development, Environment and Lifestyle study of PME from birth to 36 months was conducted in the USA and NZ. The US cohort included 204 children with PME and 212 non-PME matched comparisons (NPME); the NZ cohort included 108 children with PME and 115 NPME matched comparisons. Latent growth curve models were used to examine effects of PME, country of origin, and the country x PME interaction on growth in length/height and weight. In regard to length/height, PME and country of origin were associated with initial length and growth over time. There was also a significant interaction effect, such that children with PME in the USA were shorter at birth than children with PME in NZ after controlling for other prenatal exposures, infant set, socioeconomic status, and maternal height. In regard to weight, there was only an effect of country of origin. Effects of PME on infant and child growth were shown to differ across countries, with exposed children in NZ faring better than exposed children in the USA. Implications for prevention programs and public policy are discussed.
C1 [Abar, Beau; LaGasse, Linda L.; Della Grotta, Sheri; Dansereau, Lynne M.; Wilcox, Tara; Lester, Barry M.] Women & Infants Hosp RI, Alpert Med Sch, Brown Ctr Study Children Risk, Providence, RI 02905 USA.
   [Wouldes, Trecia] Univ Auckland, Dept Psychol Med, Auckland 1, New Zealand.
   [Derauf, Chris; Neal, Charles R.] Univ Hawaii, Dept Pediat, John A Burns Sch Med, Pearl City, HI USA.
   [Newman, Elana] Univ Tulsa, Dept Psychol, Tulsa, OK 74104 USA.
   [Shah, Rizwan] Iowa Hlth, Blank Hosp Reg Child Protect Ctr, Des Moines, IA USA.
   [Smith, Lynne M.] Harbor UCLA Med Ctr, Dept Pediat, LABioMed Inst, Los Angeles, CA USA.
   [Arria, Amelia M.] Univ Maryland, Sch Publ Hlth, Ctr Young Adult Hlth & Dev, Family Sci Dept, College Pk, MD 20742 USA.
   [Huestis, Marilyn A.] NIDA, Intramural Res Program, Bethesda, MD 20892 USA.
RP Abar, B (reprint author), Women & Infants Hosp RI, Alpert Med Sch, Brown Ctr Study Children Risk, 50 Holden St, Providence, RI 02905 USA.
EM babar@wihri.org
OI Arria, Amelia/0000-0002-6360-9265; Wouldes, Trecia/0000-0002-6609-8464
FU NCATS NIH HHS [UL1 TR000124, KL2 TR000095]; NIDA NIH HHS [R01 DA021757]
NR 55
TC 1
Z9 1
U1 5
U2 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-4986
EI 1573-6695
J9 PREV SCI
JI Prev. Sci.
PD OCT
PY 2014
VL 15
IS 5
BP 767
EP 776
DI 10.1007/s11121-013-0431-5
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AT3AK
UT WOS:000344806200017
PM 23943149
ER

PT J
AU Greathouse, KL
   Chriqui, J
   Moser, RP
   Agurs-Collins, T
   Perna, FM
AF Greathouse, K. Leigh
   Chriqui, Jamie
   Moser, Richard P.
   Agurs-Collins, Tanya
   Perna, Frank M.
TI The association of soda sales tax and school nutrition laws: a
   concordance of policies
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Soda tax; Competitive foods; Policy; School
ID SUGAR-SWEETENED BEVERAGES; CLASSIFICATION-SYSTEM; VENDING MACHINES; SOFT
   DRINKS; CONSUMPTION; OBESITY; TAXATION; FOOD; ADOLESCENTS; PREVENTION
AB Objective: The current research examined the association between state disfavoured tax on soda (i.e. the difference between soda sales tax and the tax on food products generally) and a summary score representing the strength of state laws governing competitive beverages (beverages that compete with the beverages in the federally funded school lunch programme) in US schools.
   Design: The Classification of Laws Associated with School Students (CLASS) summary score reflected the strength of a state's laws restricting competitive beverages sold in school stores, vending machines, school fundraisers and a la carte cafeteria items. Bridging the Gap (BTG) is a nationally recognized research initiative that provided state-level soda tax data. The main study outcome was the states' competitive beverage summary scores for elementary, middle and high school grade levels, as predicted by the states' disfavoured soda tax. Univariate and multivariate analyses were conducted, adjusting for year and state.
   Setting: Data from BTG and CLASS were used.
   Subjects: BTG and CLASS data from all fifty states and the District of Columbia from 2003 to 2010 were used.
   Results: A higher disfavoured soda sales tax was generally associated with an increased likelihood of having strong school beverage laws across grade levels, and especially when disfavoured soda sales tax was >5%.
   Conclusions: These data suggest a concordance between states' soda taxes and laws governing beverages sold in schools. States with high disfavoured sales tax on soda had stronger competitive beverage laws, indicating that the state sales tax environment may be associated with laws governing beverage policy in schools.
C1 [Greathouse, K. Leigh; Moser, Richard P.; Agurs-Collins, Tanya; Perna, Frank M.] NCI, Hlth Behav Res Branch, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
   [Greathouse, K. Leigh] NCI, Canc Prevent Fellowship Program, Rockville, MD USA.
   [Chriqui, Jamie] Univ Illinois, Inst Hlth Res & Policy, Chicago, IL USA.
RP Greathouse, KL (reprint author), NCI, Hlth Behav Res Branch, Behav Res Program, Div Canc Control & Populat Sci, 6130 Execut Blvd, Bethesda, MD 20892 USA.
EM greathousekl@mail.nih.gov
FU National Cancer Institute [N02-PC-444006, 263-MQ-515012]; Cancer
   Prevention Program; National Cancer Institute nor the Cancer Prevention
   Fellowship Program
FX Sources of funding: Support for this project was provided by the
   National Cancer Institute under contract numbers N02-PC-444006 and
   263-MQ-515012 to The Maya Tech Corporation and from the Cancer
   Prevention Program. Neither the National Cancer Institute nor the Cancer
   Prevention Fellowship Program had a role in design, analysis or writing
   of this article.
NR 22
TC 2
Z9 2
U1 3
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD OCT
PY 2014
VL 17
IS 10
BP 2201
EP 2206
DI 10.1017/S1368980013003029
PG 6
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA AS9DT
UT WOS:000344544100009
PM 24477116
ER

PT J
AU Lally, N
   Nugent, AC
   Luckenbaugh, DA
   Ameli, R
   Roiser, JP
   Zarate, CA
AF Lally, N.
   Nugent, A. C.
   Luckenbaugh, D. A.
   Ameli, R.
   Roiser, J. P.
   Zarate, C. A.
TI Anti-anhedonic effect of ketamine and its neural correlates in
   treatment-resistant bipolar depression
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID D-ASPARTATE ANTAGONIST; REUPTAKE INHIBITOR TREATMENT; HAMILTON PLEASURE
   SCALE; ASTROCYTIC GLUTAMATE UPTAKE; PLACEBO-CONTROLLED TRIAL; ADD-ON
   TRIAL; MAJOR DEPRESSION; NUCLEUS-ACCUMBENS; ANTERIOR CINGULATE;
   PREFRONTAL CORTEX
AB Anhedonia-which is defined as diminished pleasure from, or interest in, previously rewarding activities-is one of two cardinal symptoms of a major depressive episode. However, evidence suggests that standard treatments for depression do little to alleviate the symptoms of anhedonia and may cause reward blunting. Indeed, no therapeutics are currently approved for the treatment of anhedonia. Notably, over half of patients diagnosed with bipolar disorder experience significant levels of anhedonia during a depressive episode. Recent research into novel and rapid-acting therapeutics for depression, particularly the noncompetitive N-Methyl-D-aspartate receptor antagonist ketamine, has highlighted the role of the glutamatergic system in the treatment of depression; however, it is unknown whether ketamine specifically improves anhedonic symptoms. The present study used a randomized, placebo-controlled, double-blind crossover design to examine whether a single ketamine infusion could reduce anhedonia levels in 36 patients with treatment-resistant bipolar depression. The study also used positron emission tomography imaging in a subset of patients to explore the neurobiological mechanisms underpinning ketamine's anti-anhedonic effects. We found that ketamine rapidly reduced the levels of anhedonia. Furthermore, this reduction occurred independently from reductions in general depressive symptoms. Anti-anhedonic effects were specifically related to increased glucose metabolism in the dorsal anterior cingulate cortex and putamen. Our study emphasizes the importance of the glutamatergic system in treatment-refractory bipolar depression, particularly in the treatment of symptoms such as anhedonia.
C1 [Lally, N.; Nugent, A. C.; Luckenbaugh, D. A.; Ameli, R.; Zarate, C. A.] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA.
   [Lally, N.; Roiser, J. P.] UCL, Inst Cognit Neurosci, London, England.
RP Lally, N (reprint author), NIMH, Expt Therapeut & Pathophysiol Branch, NIH, CRC, 10 Ctr Dr,Room 7-5340, Bethesda, MD 20892 USA.
EM lallynm@mail.nih.gov
FU Intramural Research Program at the National Institute of Mental Health,
   National Institutes of Health (IRP-NIMH-NIH) [04-M-0222]; National
   Alliance for Research on Schizophrenia and Depression Award; Wellcome
   Trust-NIH [WT095465]
FX The authors thank Wayne Drevets MD and Maura Furey PhD for helpful
   discussions related to the manuscript, loline Henter, MA for outstanding
   editorial assistance and the 7SE research unit and staff for their
   support. Funding for this work was supported by the Intramural Research
   Program at the National Institute of Mental Health, National Institutes
   of Health (IRP-NIMH-NIH; grant number 04-M-0222), by a National Alliance
   for Research on Schizophrenia and Depression Award to CAZ, and by a
   Wellcome Trust-NIH PhD studentship (WT095465) to NL.
NR 89
TC 38
Z9 38
U1 9
U2 15
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD OCT
PY 2014
VL 4
AR e469
DI 10.1038/tp.2014.105
PG 9
WC Psychiatry
SC Psychiatry
GA AT3HT
UT WOS:000344827100013
PM 25313512
ER

PT J
AU Li, JH
   Vootukuri, S
   Shang, Y
   Negri, A
   Jiang, JK
   Nedelman, M
   Diacovo, TG
   Filizola, M
   Thomas, CJ
   Coller, BS
AF Li, Jihong
   Vootukuri, Spandana
   Shang, Yi
   Negri, Ana
   Jiang, Jian-kang
   Nedelman, Mark
   Diacovo, Thomas G.
   Filizola, Marta
   Thomas, Craig J.
   Coller, Barry S.
TI RUC-4 A Novel alpha IIb beta 3 Antagonist for Prehospital Therapy of
   Myocardial Infarction
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE blood platelets; myocardial infarction
ID PERCUTANEOUS CORONARY INTERVENTION; GLYCOPROTEIN-IIB-IIIA; IIB/IIIA
   RECEPTOR INHIBITORS; ENSEMBLE MONTE-CARLO; HEART-FAILURE; INTEGRIN
   ALPHA(IIB)BETA(3); GPIIB/IIIA ANTAGONISTS; CONFORMATIONAL-CHANGES;
   PLATELET-AGGREGATION; ACC/AHA GUIDELINES
AB Objective-Treatment of myocardial infarction within the first 1 to 2 hours with a thrombolytic agent, percutaneous coronary intervention, or an alpha IIb beta 3 antagonist decreases mortality and the later development of heart failure. We previously reported on a novel small molecule alpha IIb beta 3 antagonist, RUC-2, that has a unique mechanism of action. We have now developed a more potent and more soluble congener of RUC-2, RUC-4, designed to be easily administered intramuscularly by autoinjector to facilitate its use in the prehospital setting. Here, we report the properties of RUC-4 and the antiplatelet and antithrombotic effects of RUC-2 and RUC-4 in animal models.
   Approach and Results-RUC-4 was approximate to 20% more potent than RUC-2 in inhibiting human ADP-induced platelet aggregation and much more soluble in aqueous solutions (60-80 mg/mL). It shared RUC-2's specificity for alpha IIb beta 3 versus alpha V beta 3, did not prime the receptor to bind fibrinogen, or induce changes in beta 3 identified by a conformation-specific monoclonal antibody. Both RUC-2 and RUC-4 prevented FeCl3-induced thrombotic occlusion of the carotid artery in mice and decreased microvascular thrombi in response to laser injury produced by human platelets infused into transgenic mice containing a mutated von Willebrand factor that reacts with human but not mouse platelets. Intramuscular injection of RUC-4 in nonhuman primates at 1.9 and 3.85 mg/kg led to complete inhibition of platelet aggregation within 15 minutes, with dose-dependent return of platelet aggregation after 4.5 to 24 hours.
   Conclusions-RUC-4 has favorable biochemical, pharmacokinetic, pharmacodynamic, antithrombotic, and solubility properties as a prehospital therapy of myocardial infarction, but the possibility of increased bleeding with therapeutic doses remains to be evaluated.
C1 [Li, Jihong; Vootukuri, Spandana; Coller, Barry S.] Rockefeller Univ, Allen & Frances Adler Lab Blood & Vasc Biol, New York, NY 10065 USA.
   [Shang, Yi; Negri, Ana; Filizola, Marta] Icahn Sch Med Mt Sinai, Dept Struct & Chem Biol, New York, NY 10029 USA.
   [Jiang, Jian-kang; Thomas, Craig J.] NIH, Chem Genom Ctr, Div Preclin Innovat, Natl Ctr Adv Translat Sci, Bethesda, MD 20892 USA.
   [Nedelman, Mark] Ekam Imaging, Boston, MA USA.
   [Diacovo, Thomas G.] Columbia Univ, Dept Pediat, Med Ctr, New York, NY 10027 USA.
   [Diacovo, Thomas G.] Columbia Univ, Dept Pathol, Med Ctr, New York, NY USA.
RP Coller, BS (reprint author), Rockefeller Univ, Allen & Frances Adler Lab Blood & Vasc Biol, 1230 York Ave, New York, NY 10065 USA.
EM collerb@rockefeller.edu
FU National Institutes of Health, National Heart, Lung, and Blood Institute
   [19278]; National Center for Advancing Translational Sciences Clinical
   and Translational Science Award [UL1TR000043]; Rockefeller University;
   Stony Brook University; Division of Preclinical Innovation, National
   Center for Advancing Translational Sciences; Molecular Libraries
   Initiative of the National Institutes of Health Roadmap for Medical
   Research;  [U54CA143930]
FX This work was supported, in part, by National Institutes of Health grant
   National Heart, Lung, and Blood Institute 19278 and National Center for
   Advancing Translational Sciences Clinical and Translational Science
   Award UL1TR000043, as well as funds from Rockefeller University (Bridges
   to Better Medicine Award) and Stony Brook University. It was also
   supported, in part, by the Division of Preclinical Innovation, National
   Center for Advancing Translational Sciences, the Molecular Libraries
   Initiative of the National Institutes of Health Roadmap for Medical
   Research, and grant number U54CA143930.
NR 55
TC 6
Z9 7
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD OCT
PY 2014
VL 34
IS 10
BP 2321
EP +
DI 10.1161/ATVBAHA.114.303724
PG 18
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA AS1QU
UT WOS:000344056100023
PM 25147334
ER

PT J
AU Cunningham, BK
   Khromykh, A
   Martinez, AF
   Carney, T
   Hadley, DW
   Solomon, BD
AF Cunningham, Bridget K.
   Khromykh, Alina
   Martinez, Ariel F.
   Carney, Tyler
   Hadley, Donald W.
   Solomon, Benjamin D.
TI Analysis of Renal Anomalies in VACTERL Association
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Article
DE VACTERL; VACTERL association; VATER; VATER association; renal anomalies
ID URINARY-TRACT-INFECTION; VATER ASSOCIATION; CONGENITAL-ANOMALIES;
   ESOPHAGEAL ATRESIA; VERTEBRAL DEFECTS; MALFORMATIONS; SPECTRUM;
   CHILDREN; INFANTS; FISTULA
AB Background: VACTERL association refers to a combination of congenital anomalies that can include: vertebral anomalies, anal atresia, cardiac malformations, tracheo-esophageal fistula with esophageal atresia, renal anomalies (typically structural renal anomalies), and limb anomalies. Methods: We conducted a description of a case series to characterize renal findings in a cohort of patients with VACTERL association. Out of the overall cohort, 48 patients (with at least three component features of VACTERL and who had abdominal ultrasound performed) met criteria for analysis. Four other patients were additionally analyzed separately, with the hypothesis that subtle renal system anomalies may occur in patients who would not otherwise meet criteria for VACTERL association. Results: Thirty-three (69%) of the 48 patients had a clinical manifestation affecting the renal system. The most common renal manifestation (RM) was vesicoureteral reflux (VUR) in addition to a structural defect (present in 27%), followed by unilateral renal agenesis (24%), and then dysplastic/multicystic kidneys or duplicated collected system (18% for each). Twenty-two (88%) of the 25 patients with a structural RM had an associated anorectal malformation. Individuals with either isolated lower anatomic anomalies, or both upper and lower anatomic anomalies were not statistically more likely to have a structural renal defect than those with isolated upper anatomic anomalies (p=0.22, p=0.284, respectively). Conclusion: Given the high prevalence of isolated VUR in our cohort, we recommend a screening VCUG or other imaging modality be obtained to evaluate for VUR if initial renal ultrasound shows evidence of obstruction or renal scarring, as well as ongoing evaluation of renal health. (C) 2014 Wiley Periodicals, Inc.
C1 [Cunningham, Bridget K.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA.
   [Cunningham, Bridget K.; Martinez, Ariel F.; Carney, Tyler; Hadley, Donald W.; Solomon, Benjamin D.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Khromykh, Alina; Solomon, Benjamin D.] Inova Translat Med Inst, Falls Church, VA 22042 USA.
   [Khromykh, Alina; Solomon, Benjamin D.] Inova Childrens Hosp, Dept Pediat, Inova Hlth Syst, Falls Church, VA USA.
RP Solomon, BD (reprint author), Inova Translat Med Inst, Claude Moore Bldg,3300 Gallows Rd, Falls Church, VA 22042 USA.
EM benjamin.solomon@inova.org
FU National Human Genome Research Institute, National Institutes of Health;
   Inova Translational Medicine Institute, Inova Health System
FX This research was supported (in part) by the Intramural Research Program
   of the National Human Genome Research Institute, National Institutes of
   Health, and by the Inova Translational Medicine Institute, Inova Health
   System. Pertaining to Dr. Cunningham, the views expressed in this
   article are those of the authors and do not necessarily reflect the
   official policy or position of the Department of the Navy, nor the U. S.
   Government. All of the authors express their deepest gratitude to the
   patients and families who participate in their research on VACTERL
   association and related disorders. We acknowledge Drs. Max Muenke,
   Joseph G. Vockley, and John E. Niederhuber for their support, and Dr.
   Joanna Cohen for expert assistance with ultrasound interpretation.
NR 24
TC 5
Z9 5
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD OCT
PY 2014
VL 100
IS 10
BP 801
EP 805
DI 10.1002/bdra.23302
PG 5
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA AS5YT
UT WOS:000344343100010
PM 25196458
ER

PT J
AU Manning, J
   Brown, G
   Vogelsong, K
   Kildebeck, M
   Zwerski, S
   Blithe, D
AF Manning, J.
   Brown, G.
   Vogelsong, K.
   Kildebeck, M.
   Zwerski, S.
   Blithe, D.
TI Challenges and opportunities in funding the development and introduction
   of multipurpose prevention technologies
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Editorial Material
C1 [Manning, J.] US Agcy Int Dev, Div Res, Off Populat & Reprod Hlth, Washington, DC 20523 USA.
   [Brown, G.] NIH, Off AIDS Res, Bethesda, MD 20892 USA.
   [Vogelsong, K.] Bill & Melinda Gates Fdn, Global Dev Program, Family Planning Div, Seattle, WA USA.
   [Kildebeck, M.] Mary Wohlford Fdn, San Francisco, CA USA.
   [Zwerski, S.] NIAID, Div Aids, Prevent Sci Program, Bethesda, MD USA.
   [Blithe, D.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Contracept Discovery & Dev Branch, NIH, Bethesda, MD USA.
RP Manning, J (reprint author), US Agcy Int Dev, Div Res, Off Populat & Reprod Hlth, 1300 Penn Ave NW, Washington, DC 20523 USA.
EM jmanning@usaid.gov
NR 0
TC 4
Z9 4
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD OCT
PY 2014
VL 121
SU 5
SI SI
BP 12
EP 14
DI 10.1111/1471-0528.13024
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AS6WE
UT WOS:000344399300004
PM 25335834
ER

PT J
AU Beygui, F
   Wild, PS
   Zeller, T
   Germain, M
   Castagne, R
   Lackner, KJ
   Munzel, T
   Montalescot, G
   Mitchell, GF
   Verwoert, GC
   Tarasov, KV
   Tregouet, DA
   Cambien, F
   Blankenberg, S
   Tiret, L
AF Beygui, Farzin
   Wild, Philipp S.
   Zeller, Tanja
   Germain, Marine
   Castagne, Raphaele
   Lackner, Karl J.
   Muenzel, Thomas
   Montalescot, Gilles
   Mitchell, Gary F.
   Verwoert, Germaine C.
   Tarasov, Kirill V.
   Tregouet, David-Alexandre
   Cambien, Francois
   Blankenberg, Stefan
   Tiret, Laurence
TI Adrenomedullin and Arterial Stiffness Integrative Approach Combining
   Monocyte ADM Expression, Plasma MR-Pro-ADM, and Genome-Wide Association
   Study
SO CIRCULATION-CARDIOVASCULAR GENETICS
LA English
DT Article
DE adrenomedullin; gene expression; genome wide association scan; vascular
   stiffness
ID PULSE-WAVE VELOCITY; NONINVASIVE VASCULAR FUNCTION;
   CARDIOVASCULAR-DISEASE RISK; MIDREGIONAL-PROADRENOMEDULLIN; PROGNOSTIC
   VALUE; BLOOD-PRESSURE; GENERAL-POPULATION; CHINESE POPULATION;
   BIOMARKERS; C-TERMINAL-PRO-ENDOTHELIN-1
AB Background Adrenomedullin (ADM) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function. Single nucleotide polymorphisms of the ADM gene are associated with blood pressure variability, and elevated levels of plasma midregional proadrenomedullin (MR-pro-ADM) are associated with cardiovascular diseases.
   Methods and Results We investigated the sources of variability of ADM gene expression and plasma MR-pro-ADM concentrations in the general population, and their relationship with markers of atherosclerosis. MR-pro-ADM levels were assessed in 4155 individuals who underwent evaluation of carotid intima-media thickness and arterial rigidity (reflection index and stiffness index). In a subsample of 1372 individuals, ADM gene expression was assessed as part of a transcriptomic study of circulating monocytes. Nongenetic factors explained 45.8% and 7.5% of MR-pro-ADM and ADM expression variability, respectively. ADM expression correlated with plasma C-reactive protein, interleukin-receptor 1A, and myeloperoxidase, whereas MR-pro-ADM levels correlated with C-terminal proendothelin-1, creatinine, and N-terminal pro-B-type natriuretic peptide. Genome-wide association study of ADM expression and MR-pro-ADM levels both identified a single locus encompassing the ADM gene. ADM expression was associated with 1 single nucleotide polymorphism rs11042717 (P=2.36x10(-12)), whereas MR-pro-ADM was associated with 2 single nucleotide polymorphisms with additive effects, rs2957692 (P=1.54x10(-13)) and rs2957717 (P=4.24x10(-8)). Reflection index was independently associated with rs11042717 (P<10(-4)) and ADM expression (P=0.0002) but not with MR-pro-ADM. Weaker associations were observed for stiffness index. Intima-media thickness was not related to ADM single nucleotide polymorphisms or expression.
   Conclusions These results support an involvement of the ADM gene in the modulation of peripheral vascular tone.
C1 [Beygui, Farzin; Germain, Marine; Castagne, Raphaele; Montalescot, Gilles; Tregouet, David-Alexandre; Cambien, Francois; Tiret, Laurence] Univ Paris 06, Sorbonne Univ, ICAN Inst Cardiometab & Nutr, INSERM,UMR S 1166, Paris, France.
   [Beygui, Farzin] Caen Univ Hosp, Dept Cardiol, Caen, France.
   [Wild, Philipp S.; Muenzel, Thomas] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, D-55122 Mainz, Germany.
   [Wild, Philipp S.] Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis, Univ Med Ctr, D-55122 Mainz, Germany.
   [Lackner, Karl J.] Johannes Gutenberg Univ Mainz, Inst Clin Chem & Lab Med, Univ Med Ctr, D-55122 Mainz, Germany.
   [Zeller, Tanja; Blankenberg, Stefan] Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, D-20246 Hamburg, Germany.
   [Montalescot, Gilles] Univ Paris 06, CHU Pitie Salpetriere, AP HP, ACT Grp,Inst Cardiol, Paris, France.
   [Mitchell, Gary F.] Cardiovasc Engn Inc, Norwood, MA USA.
   [Verwoert, Germaine C.] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Tarasov, Kirill V.] NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA.
RP Tiret, L (reprint author), INSERM, UMR S 1166, 91 Blvd Hop, F-75634 Paris 13, France.
EM s.blankenberg@uke.de; laurence.tiret@upmc.fr
RI Tregouet, David-Alexandre/E-3961-2016
FU government of Rheinland-Pfalz; Stiftung Rheinland-Pfalz fur Innovation
   [AZ 961-386261/733]; research programs Wissen schafft Zukunft and
   Schwerpunkt Vaskulare Prevention of the Johannes Gutenberg-University of
   Mainz; Boehringer Ingelheim; PHILIPS Medical Systems; National Genome
   Network NGFNplus [01GS0833, 01GS0831]; Bundesministerium fur Bildung und
   Forschung; Agence Nationale de la Recherche, France; Bundesministerium
   fur Bildung und Forschung [01KU0908A, ANR 09 GENO 106 01]; Fondation
   pour la Recherche Medicale [ING20091218112]
FX The Gutenberg Health Study is funded through the government of
   Rheinland-Pfalz (http://www.rlp.de/; Stiftung Rheinland-Pfalz fur
   Innovation, contract AZ 961-386261/733), the research programs Wissen
   schafft Zukunft and Schwerpunkt Vaskulare Prevention of the Johannes
   Gutenberg-University of Mainz (http://www.uni-mainz.de/), and its
   contract with Boehringer Ingelheim (http://www.boehringer-ingelheim.de/)
   and PHILIPS Medical Systems (http://www.healthcare.philips.com/),
   including an unrestricted grant for the Gutenberg Health Study.
   Specifically, the research reported in this article was supported by the
   National Genome Network NGFNplus (http://www.ngfn.de/en/start.html;
   contract 01GS0833 and 01GS0831) by the Bundesministerium fur Bildung und
   Forschung, and a joint funding grant from the Bundesministerium fur
   Bildung und Forschung, and the Agence Nationale de la Recherche, France
   (http://www.agence-nationale-recherche.fr; contract Bundesministerium
   fur Bildung und Forschung 01KU0908A and ANR 09 GENO 106 01). Dr Beygui
   was supported by a grant from the Fondation pour la Recherche Medicale
   (contract ING20091218112).
NR 31
TC 2
Z9 2
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1942-325X
EI 1942-3268
J9 CIRC-CARDIOVASC GENE
JI Circ.-Cardiovasc. Genet.
PD OCT
PY 2014
VL 7
IS 5
BP 634
EP 641
DI 10.1161/CIRCGENETICS.113.000456
PG 8
WC Cardiac & Cardiovascular Systems; Genetics & Heredity
SC Cardiovascular System & Cardiology; Genetics & Heredity
GA AS6IU
UT WOS:000344368200010
PM 25053723
ER

PT J
AU Hao, C
   Zhang, C
   Chen, W
   Shi, Z
AF Hao, C.
   Zhang, C.
   Chen, W.
   Shi, Z.
TI Prevalence and risk factors of diabetes and impaired fasting glucose
   among university applicants in Eastern China: findings from a
   population-based study
SO DIABETIC MEDICINE
LA English
DT Article
ID ALANINE AMINOTRANSFERASE; INTERNATIONAL SURVEY; CHILDHOOD OBESITY;
   CHILDREN; ADOLESCENTS; OVERWEIGHT; MELLITUS; HEALTH; TRENDS; ADULTS
AB Aims To investigate the prevalence and risk factors of diabetes and impaired fasting glucose among urban university applicants in Eastern China.
   Method The study uses data from the annual health examination among all students finishing high school who applied for university entrance in Changzhou City in 2012. In total, 6716 students aged 17-19 years had fasting blood glucose, alanine transaminase, height, weight and blood pressure measured. Impaired fasting glucose and diabetes were defined as fasting blood glucose >= 5.6 mmol/l (but < 7 mmol/l) and >= 7 mmol/l, respectively.
   Results The overall prevalence of impaired fasting glucose and diabetes was 2.40% and 0.13%, respectively (3.67% and 0.09% in boys; 1.09% and 0.18% in girls). In total, 20.9% of boys and 10.6% of girls were overweight/obese. High socio-economic status was associated with an increased risk of diabetes/impaired fasting glucose, but the association was significant only among boys (adjusted odds ratio 1.94, 95% CI 1.26-2.98). Alanine transaminase levels were significantly and positively related to diabetes/impaired fasting glucose risk. Overweight/obesity was significantly associated with increased risk of impaired fasting glucose/diabetes in girls, but not in boys. Moreover, the number of the above-mentioned risk factors (i.e. overweight/obesity, elevated alanine transaminase, pre-hypertension) was significantly and positively related to diabetes/impaired fasting glucose among both boys and girls.
   Conclusions Impaired fasting glucose was prevalent among urban university applicants, in particular boys and those of high socio-economic status in eastern China. Elevated levels of liver function enzyme appear to be the strongest risk factor for diabetes/impaired fasting glucose.
C1 [Hao, C.; Chen, W.] Changzhou Ctr Dis Control & Prevent, Changzhou, Peoples R China.
   [Zhang, C.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, Bethesda, MD USA.
   [Shi, Z.] Univ Adelaide, Adelaide, SA, Australia.
RP Shi, Z (reprint author), Univ Adelaide, Adelaide, SA, Australia.
EM Zumin.shi@adelaide.edu.au
RI Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299
FU Intramural Research Program of the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, National Institutes of
   Health
FX CZ was supported by the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health.
NR 27
TC 2
Z9 2
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD OCT
PY 2014
VL 31
IS 10
BP 1194
EP 1198
DI 10.1111/dme.12473
PG 5
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AS1AY
UT WOS:000344009900007
PM 24766092
ER

PT J
AU David, VA
   Menotti-Raymond, M
   Wallace, AC
   Roelke, M
   Kehler, J
   Leighty, R
   Eizirik, E
   Hannah, SS
   Nelson, G
   Schaffer, AA
   Connelly, CJ
   O'Brien, SJ
   Ryugo, DK
AF David, Victor A.
   Menotti-Raymond, Marilyn
   Wallace, Andrea Coots
   Roelke, Melody
   Kehler, James
   Leighty, Robert
   Eizirik, Eduardo
   Hannah, Steven S.
   Nelson, George
   Schaeffer, Alejandro A.
   Connelly, Catherine J.
   O'Brien, Stephen J.
   Ryugo, David K.
TI Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and
   White spotting in Domestic Cats
SO G3-GENES GENOMES GENETICS
LA English
DT Article
DE White; domestic cat; deaf; white spotting; retrotransposition; FERV1
ID WAARDENBURG-HIRSCHSPRUNG-DISEASE; ENDOTHELIN-B RECEPTOR; COAT COLOR
   PHENOTYPES; PROTOONCOGENE C-KIT; FELIS-CATUS; W-LOCUS; GENETIC
   INDIVIDUALIZATION; EPIDERMAL MELANOCYTES; COCHLEAR NUCLEUS;
   AUDITORY-NERVE
AB The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and white spotting. A full-length (7125 bp) FERV1 element is associated with white spotting, whereas a FERV1 long terminal repeat (LTR) is associated with all Dominant White individuals. For purposes of statistical analysis, the alternatives of wild-type sequence, FERV1 element, and LTR-only define a triallelic marker. Taking into account pedigree relationships, deafness is genetically linked and associated with this marker; estimated P values for association are in the range of 0.007 to 0.10. The retrotransposition interrupts a DNAase I hypersensitive site in KIT intron 1 that is highly conserved across mammals and was previously demonstrated to regulate temporal and tissue-specific expression of KIT in murine hematopoietic and melanocytic cells. A large-population genetic survey of cats (n = 270), representing 30 cat breeds, supports our findings and demonstrates statistical significance of the FERV1 LTR and full-length element with Dominant White/blue iris (P<0.0001) and white spotting (P<0.0001), respectively.
C1 [David, Victor A.; Menotti-Raymond, Marilyn; Wallace, Andrea Coots; O'Brien, Stephen J.] NCI, Lab Genom Divers, Ctr Canc Res, Frederick, MD 21702 USA.
   [Roelke, Melody] Leidos Biomed Res Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
   [Roelke, Melody] Bethesda Leidos Biomed Res, LASP, Bethesda, MD 20892 USA.
   [Kehler, James] NIDDK, Lab Cell & Mol Biol, NIH, Bethesda, MD 20814 USA.
   [Leighty, Robert] NCI, Data Management Serv Inc, Frederick, MD 21702 USA.
   [Eizirik, Eduardo] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, BR-90619900 Porto Alegre, RS, Brazil.
   [Eizirik, Eduardo] Inst Procarnivoros, BR-12945010 Sao Paulo, Brazil.
   [Hannah, Steven S.] Nestle Purina PetCare, St Louis, MO 63164 USA.
   [Nelson, George] Frederick Natl Lab, BSP CCR Genet Core, Frederick, MD 21702 USA.
   [Schaeffer, Alejandro A.] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
   [Connelly, Catherine J.; Ryugo, David K.] Garvan Inst Med Res, Sydney, NSW, Australia.
   [O'Brien, Stephen J.] St Petersburg State Univ, Theodosius Dobzhansky Ctr Genome Bioinformat, St Petersburg 199034, Russia.
   [Ryugo, David K.] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Ctr Hearing Sci, Baltimore, MD 21205 USA.
RP Menotti-Raymond, M (reprint author), 5115 Westridge Rd, Bethesda, MD 20816 USA.
EM Marilyn.Menotti@gmail.com
RI Eizirik, Eduardo/K-8034-2012; Ryugo, David/G-1940-2012
OI Eizirik, Eduardo/0000-0002-9658-0999; Ryugo, David/0000-0002-5250-7503
FU National Cancer Institute, National Institutes of Health
   [HHSN26120080001E]; National Library of Medicine; NIH/NIDCD [DC00232];
   NHMRC [1009482]; Fairfax Foundation; Intramural Research Program of the
   NIH, National Cancer Institute, Center for Cancer Research; Russian
   Ministry of Science Mega-grant [11.G34.31.0068]
FX We thank Richard Frederickson and Joseph Meyer (Scientific Publications,
   Graphics & Media, SAIC-Frederick) for rendition of figures. This project
   has been funded in whole or in part with federal funds from the National
   Cancer Institute, National Institutes of Health, under contract
   HHSN26120080001E, the National Library of Medicine, NIH/NIDCD grant
   DC00232, NHMRC grant #1009482, and the Fairfax Foundation. This research
   was supported (in part) by the Intramural Research Program of the NIH,
   National Cancer Institute, Center for Cancer Research, and the National
   Library of Medicine. This research was supported in part by Russian
   Ministry of Science Mega-grant no. 11.G34.31.0068 (S.J.O., primary
   investigator).
NR 101
TC 12
Z9 12
U1 6
U2 19
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 2160-1836
J9 G3-GENES GENOM GENET
JI G3-Genes Genomes Genet.
PD OCT 1
PY 2014
VL 4
IS 10
BP 1881
EP 1891
DI 10.1534/g3.114.013425
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA AR9WZ
UT WOS:000343928700009
PM 25085922
ER

PT J
AU Martinez, M
   Galeano, ME
   Akopov, A
   Palacios, R
   Russomando, G
   Kirkness, EF
   Parra, GI
AF Martinez, Magaly
   Galeano, Maria E.
   Akopov, Asmik
   Palacios, Ruth
   Russomando, Graciela
   Kirkness, Ewen F.
   Parra, Gabriel I.
TI Whole-genome analyses reveals the animal origin of a rotavirus G4P[6]
   detected in a child with severe diarrhea
SO INFECTION GENETICS AND EVOLUTION
LA English
DT Article
DE Rotavirus; G4; Zoonosis; Diarrhea; Paraguay
ID GROUP-A ROTAVIRUSES; PORCINE ROTAVIRUS; IMMUNIZATION PROGRAM; VP7 GENES;
   INTERSPECIES TRANSMISSION; PHYLOGENETIC ANALYSIS; SOUTH-AFRICAN;
   STRAINS; VACCINATION; REASSORTANT
AB Group A rotaviruses are a major cause of severe gastroenteritis in children worldwide. Currently, two rotavirus vaccines are being used in vaccination programs, and one of the factors involved in lower vaccine efficacy is the mismatch among the circulating strains and the vaccine strains. Thus, the emergence of animal strains in the human population could affect the efficacy of vaccination programs. Here we report the presence of a G4P[61 strain in a Paraguayan child presenting acute gastroenteritis in 2009. Genomic analyses revealed that the strain presents a porcine-like genome (G4-P[6]-I1-R1-C1-M1-A8-N1-T7-E1-H1), suggesting a direct animal-to-human transmission. Continuous surveillance of rotaviruses in humans and animals will help us to better understand rotavirus epidemiology and evolution. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Martinez, Magaly; Galeano, Maria E.; Palacios, Ruth; Russomando, Graciela; Parra, Gabriel I.] Univ Nacl Asuncion, Inst Invest Ciencias Salud, Dept Mol Biol & Genet, Asuncion, Paraguay.
   [Akopov, Asmik; Kirkness, Ewen F.] J Craig Venter Inst, Rockville, MD USA.
RP Parra, GI (reprint author), NIAID, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM gabriel_parra@hotmail.com
OI Parra, Gabriel/0000-0002-1102-4740
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT), Paraguay; National
   Institute of Allergy and Infectious Diseases - United States; National
   Institutes of Health - United States; Department of Health and Human
   Services [HHSN272200900007C]
FX We would like to thank Norma Farina and Lilian Cantero for their help in
   collecting samples. We would also like to thank David Wentworth, Rebecca
   Halpin, Nadia Fedorova, Timothy Stockwell, and Susmita Shrivastava for
   help with genome sequencing, assembly, and annotation. This work was
   supported in part by a fellowship from Consejo Nacional de Ciencia y
   Tecnologia (CONACYT), Paraguay to MM. This project has also been funded
   in part with federal funds from the National Institute of Allergy and
   Infectious Diseases - United States, National Institutes of Health -
   United States, Department of Health and Human Services under contract
   number HHSN272200900007C.
NR 47
TC 10
Z9 10
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-1348
EI 1567-7257
J9 INFECT GENET EVOL
JI Infect. Genet. Evol.
PD OCT
PY 2014
VL 27
BP 156
EP 162
DI 10.1016/j.meegid.2014.07.020
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA AS0EU
UT WOS:000343951900020
PM 25075468
ER

PT J
AU Parascandola, M
AF Parascandola, Mark
TI Commentary: Smoking, birthweight and mortality: Jacob Yerushalmy on
   self-selection and the pitfalls of causal inference
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Editorial Material
ID CIGARETTE-SMOKING; NONSMOKERS; SMOKERS; CANCER; LUNG
C1 NCI, Tobacco Control Res Branch, Bethesda, MD 20892 USA.
RP Parascandola, M (reprint author), NCI, Tobacco Control Res Branch, 9609 Med Ctr Dr, Bethesda, MD 20892 USA.
EM paramark@mail.nih.gov
NR 33
TC 1
Z9 1
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
EI 1464-3685
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD OCT
PY 2014
VL 43
IS 5
BP 1373
EP 1377
DI 10.1093/ije/dyu163
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AS0MW
UT WOS:000343972200006
PM 25301863
ER

PT J
AU Philipsen, N
   Butler, RD
   Simon-Waterman, C
   Artis, J
AF Philipsen, Nayna
   Butler, Robin D.
   Simon-Waterman, Christie
   Artis, Jylla
TI Medical Marijuana: A Primer on Ethics, Evidence, and Politics
SO JNP-JOURNAL FOR NURSE PRACTITIONERS
LA English
DT Article
DE advanced practice registered nurse scope of practice; advocacy; barriers
   to advanced practice registered nurse practice; cannabis; compassionate
   care; criminalization; decriminalization; gateway drugs; marijuana;
   medical marijuana; palliative care; paternalism; patient autonomy;
   therapeutic cannabis
AB Controversy in the United States about the decriminalization of cannabis to allow health care providers to recommend it for therapeutic use (medical marijuana) has been based on varying policies and beliefs about cannabis rather than on scientific evidence. Issues include the duty to provide care, conflicting reports of the therapeutic advantages and risks of cannabis, inconsistent laws, and even the struggle to remove barriers to the scope of practice for advanced practice registered nurses. This article reviews the ethics, evidence, and politics of this complex debate.
C1 [Philipsen, Nayna] Coppin State Univ, Coll Hlth Profess, Baltimore, MD 21216 USA.
   [Butler, Robin D.] Coppin State Univ, Coll Hlth Profess, Hlth Informat Management Program, Baltimore, MD USA.
   [Simon-Waterman, Christie] FutureCare Hlth & Management Corp, Pasadena, CA USA.
   [Simon-Waterman, Christie; Artis, Jylla] Maryland Nurses Assoc, Baltimore, MD USA.
   [Artis, Jylla] APRN, Occupat Hlth Clin, NIH, College Pk, MD USA.
RP Philipsen, N (reprint author), Coppin State Univ, Coll Hlth Profess, Baltimore, MD 21216 USA.
EM nphilipsen@coppin.edu
NR 28
TC 4
Z9 4
U1 8
U2 42
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1555-4155
EI 1878-058X
J9 JNP-J NURSE PRACT
JI JNP-J. Nurse Pract.
PD OCT
PY 2014
VL 10
IS 9
BP 29
EP 36
DI 10.1016/j.nurpra.2014.05.015
PG 8
WC Nursing
SC Nursing
GA AS4BY
UT WOS:000344219600005
ER

PT J
AU Colbert, LH
   Matthews, CE
   Schoeller, DA
   Havighurst, TC
   Kim, K
AF Colbert, Lisa H.
   Matthews, Charles E.
   Schoeller, Dale A.
   Havighurst, Thomas C.
   Kim, KyungMann
TI Intensity of Physical Activity in the Energy Expenditure of Older Adults
SO JOURNAL OF AGING AND PHYSICAL ACTIVITY
LA English
DT Article
DE accelerometer; doubly labeled water; exercise
ID DOUBLY LABELED WATER; FUNCTIONAL LIMITATIONS; SEDENTARY BEHAVIORS;
   UNITED-STATES; ACCELEROMETER; HUMANS; ASSOCIATIONS; VALIDATION;
   COMMUNITY; SCIENCE
AB This study examined the intensity of activity contributing to physical activity energy expenditure in older adults. In 57 men and women aged >= 65, total energy expenditure (TEE) was measured using doubly labeled water and resting metabolic rate was measured using indirect calorimetry to,calculate a physical activity index (PAT). Sedentary time and physical activity of light and moderate to vigorous (mod/vig) intensity was measured using an accelerometer. The subjects were 75 +/- 7 yrs (mean +/- SD) of age and 79% female. Subjects spent 66 +/- 8, 25 +/- 5, and 9 +/- 4% of monitor wear time in sedentary, light, and mod/vig activity per day, respectively. In a mixture regression model, both light (beta = 29.6 [15.6-43.6, 95% CI]), p < .001) and mod/vig intensity activity (beta = 28.7 [7.4-50.0, 95% CI]), p = .01) were strongly associated with PAT, suggesting that both light and mod/vig intensity activities are major determinants of their physical activity energy expenditure.
C1 [Colbert, Lisa H.] Univ Wisconsin, Dept Kinesiol, Madison, WI 53706 USA.
   [Matthews, Charles E.] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Schoeller, Dale A.] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA.
   [Havighurst, Thomas C.; Kim, KyungMann] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USA.
RP Colbert, LH (reprint author), Univ Wisconsin, Dept Kinesiol, Madison, WI 53706 USA.
EM lmhcolbert@gmail.com
FU National Institutes of Health [R21 AG025839]; Clinical and Translational
   Science Award (CTSA) program, through the NIH National Center for
   Advancing Translational Sciences (NCATS) [UL1TR000427]; University of
   Wisconsin Graduate School
FX The project described was supported by the National Institutes of Health
   (R21 AG025839 to L.H.C); by the Clinical and Translational Science Award
   (CTSA) program, through the NIH National Center for Advancing
   Translational Sciences (NCATS), grant UL1TR000427; and by the University
   of Wisconsin Graduate School. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the NIH.
NR 36
TC 3
Z9 3
U1 2
U2 7
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1063-8652
EI 1543-267X
J9 J AGING PHYS ACTIV
JI J. Aging Phys. Act.
PD OCT
PY 2014
VL 22
IS 4
BP 571
EP 577
DI 10.1123/JAPA.2012-0257
PG 7
WC Geriatrics & Gerontology; Gerontology; Sport Sciences
SC Geriatrics & Gerontology; Sport Sciences
GA AS7OL
UT WOS:000344445000015
PM 24306390
ER

PT J
AU Goldstein, DS
   Sullivan, P
   Holmes, C
   Miller, GW
   Sharabi, Y
   Kopin, IJ
AF Goldstein, David S.
   Sullivan, Patricia
   Holmes, Courtney
   Miller, Gary W.
   Sharabi, Yehonatan
   Kopin, Irwin J.
TI A vesicular sequestration to oxidative deamination shift in myocardial
   sympathetic nerves in Parkinson's disease
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE catecholamines; neurochemistry; neurodegenerative mechanisms;
   Parkinson's disease; sympathetic nervous system
ID TOXIC DOPAMINE METABOLITE; ALPHA-SYNUCLEIN; CATECHOLAMINE METABOLISM;
   PC12 CELLS; NOREPINEPHRINE; DENERVATION;
   3,4-DIHYDROXYPHENYLACETALDEHYDE; STORAGE; MODEL; DEGENERATION
AB In Parkinson's disease (PD), profound putamen dopamine (DA) depletion reflects denervation and a shift from vesicular sequestration to oxidative deamination of cytoplasmic DA in residual terminals. PD also involves cardiac sympathetic denervation. Whether PD entails myocardial norepinephrine (NE) depletion and a sequestration-deamination shift have been unknown. We measured apical myocardial tissue concentrations of NE, DA, and their neuronal metabolites 3,4-dihydroxyphenylglycol (DHPG), and 3,4-dihydroxyphenylacetic acid (DOPAC) from 23 PD patients and 23 controls and ascertained the extent of myocardial NE depletion in PD. We devised, validated in VMAT2-Lo mice, and applied 5 neurochemical indices of the sequestration-deamination shiftconcentration ratios of DOPAC:DA, DA:NE, DHPG:NE, DOPAC:NE, and DHPG:DOPACand used a kinetic model to estimate the extent of the vesicular storage defect. The PD group had decreased myocardial NE content (p<0.0001). The majority of patients (70%) had severe NE depletion (mean 2% of control), and in this subgroup all five indices of a sequestration-deamination shift were increased compared to controls (p<0.001 for each). Vesicular storage in residual nerves was estimated to be decreased by 84-91% in this subgroup. We conclude that most PD patients have severe myocardial NE depletion, because of both sympathetic denervation and decreased vesicular storage in residual nerves. We found that the majority (70%) of Parkinson's disease (PD) patients have profound (98%) myocardial norepinephrine depletion, because of both cardiac sympathetic denervation and a shift from vesicular sequestration to oxidative deamination of cytoplasmic catecholamines in the residual nerves. This shift may be part of a final common pathogenetic pathway in the loss of catecholaminergic neurons that characterizes PD.
C1 [Goldstein, David S.; Sullivan, Patricia; Holmes, Courtney; Kopin, Irwin J.] NINDS, Clin Neurocardiol Sect, CNP, DIR,NIH, Bethesda, MD 20892 USA.
   [Miller, Gary W.] Emory Univ, Sch Publ Hlth, Atlanta, GA USA.
   [Sharabi, Yehonatan] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   [Sharabi, Yehonatan] Tel Aviv Univ, Tel Hashomer, Israel.
RP Goldstein, DS (reprint author), 9000 Rockville Pike,Bldg 10 Rm 5N220, Bethesda, MD 20892 USA.
EM goldsteind@ninds.nih.gov
FU National Institute of Neurological Disorders and Stroke; Division of
   Intramural Research, NIH;  [P50 NS071669]
FX We thank Dr. Thomas G. Beach and the Banner Sun Health Research
   Institute for providing most of the myocardial tissue samples used in
   this report. Mr. Shawn Alter provided the mouse heart tissue used in
   this study. The research reported here was supported by the intramural
   research program of the National Institute of Neurological Disorders and
   Stroke. This work was funded by Division of Intramural Research, NIH.
   Dr. Miller is supported by grant P50 NS071669. The authors have no
   conflict of interest to declare.
NR 44
TC 7
Z9 7
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2014
VL 131
IS 2
BP 219
EP 228
DI 10.1111/jnc.12766
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AS3GD
UT WOS:000344164500008
PM 24848581
ER

PT J
AU Reyniers, L
   Del Giudice, MG
   Civiero, L
   Belluzzi, E
   Lobbestael, E
   Beilina, A
   Arrigoni, G
   Derua, R
   Waelkens, E
   Li, Y
   Crosio, C
   Iaccarino, C
   Cookson, MR
   Baekelandt, V
   Greggio, E
   Taymans, JM
AF Reyniers, Lauran
   Del Giudice, Maria Grazia
   Civiero, Laura
   Belluzzi, Elisa
   Lobbestael, Evy
   Beilina, Alexandra
   Arrigoni, Giorgio
   Derua, Rita
   Waelkens, Etienne
   Li, Yan
   Crosio, Claudia
   Iaccarino, Ciro
   Cookson, Mark R.
   Baekelandt, Veerle
   Greggio, Elisa
   Taymans, Jean-Marc
TI Differential protein-protein interactions of LRRK1 and LRRK2 indicate
   roles in distinct celluar signaling pathways
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE LRRK1; LRRK2; Parkinson's disease; protein-protein interactions;
   signaling networks
ID REPEAT KINASE 2; DISEASE GENE LRRK2; PARKINSONS-DISEASE; CYTOPLASMIC
   LOCALIZATION; PHOSPHORYLATION CYCLE; CHAPERONE MACHINERY; 14-3-3
   BINDING; MUTATIONS; RECEPTOR; VARIANTS
AB Genetic studies show that LRRK2, and not its closest paralogue LRRK1, is linked to Parkinson's disease. To gain insight into the molecular and cellular basis of this discrepancy, we searched for LRRK1- and LRRK2-specific cellular processes by identifying their distinct interacting proteins. A protein microarray-based interaction screen was performed with recombinant 3xFlag-LRRK1 and 3xFlag-LRRK2 and, in parallel, co-immunoprecipitation followed by mass spectrometry was performed from SH-SY5Y neuroblastoma cell lines stably expressing 3xFlag-LRRK1 or 3xFlag-LRRK2. We identified a set of LRRK1- and LRRK2-specific as well as common interactors. One of our most prominent findings was that both screens pointed to epidermal growth factor receptor (EGF-R) as a LRRK1-specific interactor, while 14-3-3 proteins were LRRK2-specific. This is consistent with phosphosite mapping of LRRK1, revealing phosphosites outside of 14-3-3 consensus binding motifs. To assess the functional relevance of these interactions, SH-SY5Y-LRRK1 and -LRRK2 cell lines were treated with LRRK2 kinase inhibitors that disrupt 14-3-3 binding, or with EGF, an EGF-R agonist. Redistribution of LRRK2, not LRRK1, from diffuse cytoplasmic to filamentous aggregates was observed after inhibitor treatment. Similarly, EGF induced translocation of LRRK1, but not of LRRK2, to endosomes. Our study confirms that LRRK1 and LRRK2 can carry out distinct functions by interacting with different cellular proteins. LRRK1 and LRRK2 (leucine-rich repeat kinase) interaction partners were identified by two different protein-protein interaction screens. These confirmed epidermal growth factor receptor (EGR-R) as a LRRK1-specific interactor, while 14-3-3 proteins were LRRK2-specific. Functional analysis of these interactions and the pathways they mediate shows that LRRK1 and LRRK2 signaling do not intersect, reflective of the differential role of both LRRKs in Parkinson's disease.
C1 [Reyniers, Lauran; Lobbestael, Evy; Baekelandt, Veerle; Taymans, Jean-Marc] Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Dept Neurosci, B-3000 Leuven, Belgium.
   [Del Giudice, Maria Grazia; Crosio, Claudia; Iaccarino, Ciro] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy.
   [Civiero, Laura; Belluzzi, Elisa; Greggio, Elisa] Univ Padua, Dept Biol, Padua, Italy.
   [Beilina, Alexandra; Cookson, Mark R.] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.
   [Arrigoni, Giorgio] Univ Padua, Dept Biomed Sci, Padua, Italy.
   [Arrigoni, Giorgio] Univ Padua, Prote Ctr, Padua, Italy.
   [Derua, Rita; Waelkens, Etienne] Katholieke Univ Leuven, Dept Cellular & Mol Med, Lab Prot Phosphorylat & Prote, Leuven, Belgium.
   [Li, Yan] NINDS, Prot Peptide Sequencing Facil, NIH, Bethesda, MD 20892 USA.
RP Taymans, JM (reprint author), Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Dept Neurosci, Kapucijnenvoer 33,VCTB 5, B-3000 Leuven, Belgium.
EM jean-marc.taymans@med.kuleuven.be
FU Michael J. Fox Foundation; FWO-Vlaanderen (Research Foundation -
   Flanders) [G.0666.09, KAN2012 1.5.216.12]; IWT (Agency for Innovation by
   Science and Technology) [SBO/100042]; Belspo IAP grant [7/24]; KU Leuven
   [OT/08/052A, GOA 12/016]; P.O.R. SARDEGNA F.S.E. - Obiettivo
   competitivita regionale e occupazione, Asse IV Capitale umano, Linea di
   Attivita 1.3.1; Intramural Research Program of the National Institutes
   of Health, National Institute on Aging; Fund Druwe-Eerdekens; Telethon -
   Italy [GGP12237]; NBUR; CARIPLO foundation
FX The authors declare no conflicts of interest. This study was supported
   by the Michael J. Fox Foundation. We thank the FWO-Vlaanderen (Research
   Foundation - Flanders)-project G.0666.09, research credit KAN2012
   1.5.216.12 and fellowships to L.R., E.L. and J.-M.T., the IWT (Agency
   for Innovation by Science and Technology) SBO/100042, the Belspo IAP
   7/24 grant and the KU Leuven [OT/08/052A and GOA 12/016] for their
   support. M.G.D.G. was supported by P.O.R. SARDEGNA F.S.E. 2007-2013 -
   Obiettivo competitivita regionale e occupazione, Asse IV Capitale umano,
   Linea di Attivita 1.3.1. This research was also supported in part by the
   Intramural Research Program of the National Institutes of Health,
   National Institute on Aging and by the Fund Druwe-Eerdekens managed by
   the King Baudouin Foundation. The financial support of Telethon - Italy
   (GGP12237) is gratefully acknowledged. This work was funded by NBUR,
   CARIPLO foundation. We thank Professor Johan Hofkens and Charlotte David
   (Molecular Imaging and Photonics, KU Leuven) for the use of the confocal
   laser scanning microscope. We also acknowledge the technical assistance
   of Fangye Gao and the Leuven Viral Vector Core
   (http://www.kuleuven.be/molmed/lvvc/vectorproduction.html) for the
   production of LV vectors.
NR 55
TC 12
Z9 12
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2014
VL 131
IS 2
BP 239
EP 250
DI 10.1111/jnc.12798
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AS3GD
UT WOS:000344164500010
PM 24947832
ER

PT J
AU Bora, A
   Mohien, CU
   Chaerkady, R
   Chang, LD
   Moxley, R
   Sacktor, N
   Haughey, N
   McArthur, JC
   Cotter, R
   Nath, A
   Graham, DR
AF Bora, Adriana
   Mohien, Ceereena Ubaida
   Chaerkady, Raghothama
   Chang, Linda
   Moxley, Richard
   Sacktor, Ned
   Haughey, Norman
   McArthur, Justin C.
   Cotter, Robert
   Nath, Avindra
   Graham, David R.
TI Identification of putative biomarkers for HIV-associated neurocognitive
   impairment in the CSF of HIV-infected patients under cART therapy
   determined by mass spectrometry
SO JOURNAL OF NEUROVIROLOGY
LA English
DT Article
DE Mass spectrometry; i-TRAQ; HIV; Biomarker; Proteomics
ID ALPHA(1)-ACID GLYCOPROTEIN BINDS; ISOBARIC TAGS; TAT PROTEIN;
   QUANTITATIVE PROTEOMICS; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS;
   STATISTICAL-MODEL; APOLIPOPROTEIN-E; LTQ ORBITRAP; ITRAQ
AB We identified and measured proteins in the cerebral spinal fluid (CSF) involved in HIV-associated neurological disorders. Protein levels were determined by mass spectrometry (MS) in pooled CSF taken from three patient groups (human immunodeficiency virus (HIV)-1-infected patients that developed HIV-associated neurocognitive disorders (HANDs), HIV-1-infected patients without HAND, and healthy controls). Pools were generated from 10 patients each per group. CSF from individual patient groups were digested with trypsin and separately labeled using with isobaric tags for relative and absolute quantitation (iTRAQ). After combining all samples in one, peptides were extensively fractionated by offline two-dimensional separation and identified by tandem MS. One hundred and ninety three proteins were deemed to be interpretable for quantitation based on permutation tests with a 95 % confidence interval with a p value <= 0.05. Using a cutoff of 1.5-fold for upregulation and 0.6 for downregulation, 16 proteins were differentially expressed in HIV + HAND (reporter p value <= 0.05) with seven of them previously described as HIV-interacting proteins: endoplasmin, mitochondrial damage mediator-BH3-interacting domanin death agonist, orosomucoid, apolipoprotein E, metalloproteinase inhibitor 2, peroxiredoxin-2, and the nuclear protein, ruvB-like 2. Several previously unidentified proteins with possible neurological implication in HIV patients include forming-binding protein 1, C-reactive protein, leukocyte-associated immunoglobulin receptor 1, renin receptor, mediator of RNA polymerase II transcription subunit 14, multimerin-2, alpha-N-acetylglucosaminidase, caldesmon, and cadherin EGF LAG G-type receptor. Our results suggest that not only a few but possibly a combination of biomarkers that are highly correlated can predict neurocognitive status in HIV-infected patients and might be involved in monocyte or macrophage activation.
C1 [Bora, Adriana; Mohien, Ceereena Ubaida; Graham, David R.] Dept Mol & Comparat Pathobiol, Retrovirus Lab, Baltimore, MD 21205 USA.
   [Chaerkady, Raghothama] Johns Hopkins Univ, Sch Med, Johns Hopkins Sch Med, Mass Spectrometry & Prote Core, Baltimore, MD USA.
   [Chang, Linda] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA.
   [Bora, Adriana; Moxley, Richard; Sacktor, Ned; Haughey, Norman; McArthur, Justin C.] Univ Hawaii, Dept Neurol, Honolulu, HI 96822 USA.
   [Cotter, Robert] Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD USA.
   [Nath, Avindra] NINDS, NIH, Bethesda, MD 20892 USA.
RP Graham, DR (reprint author), Dept Mol & Comparat Pathobiol, Retrovirus Lab, Baltimore, MD 21205 USA.
EM dgraham@jhmi.edu
FU Center for Novel Therapeutics for HIV-Associated Cognitive Disorders,
   NIMH Center [2P30MH075673]; NHLBI [HHSN268201000032C]
FX The authors would like to acknowledge the following funding sources for
   this work: Center for Novel Therapeutics for HIV-Associated Cognitive
   Disorders, NIMH Center grant 2P30MH075673, and NHLBI Contract No.
   HHSN268201000032C. CSF was collected from patients that provided
   informed consent and under protocols approved by the appropriate
   institutional review boards. We would like to acknowledge that mass
   spectrometry for these studies were performed in the Johns Hopkins
   University School of Medicine Mass Spectrometry and Proteomics Core
   facility (Dr. Robert Cole, Director).
NR 60
TC 2
Z9 2
U1 2
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-0284
EI 1538-2443
J9 J NEUROVIROL
JI J. Neurovirol.
PD OCT
PY 2014
VL 20
IS 5
BP 457
EP 465
DI 10.1007/s13365-014-0263-5
PG 9
WC Neurosciences; Virology
SC Neurosciences & Neurology; Virology
GA AS2DW
UT WOS:000344090700004
PM 25056907
ER

PT J
AU Marcum, ZA
   Hanlon, JT
   Strotmeyer, ES
   Newman, AB
   Shorr, RI
   Simonsick, EM
   Bauer, DC
   Boudreau, R
   Donohue, JM
   Perera, S
AF Marcum, Zachary A.
   Hanlon, Joseph T.
   Strotmeyer, Elsa S.
   Newman, Anne B.
   Shorr, Ronald I.
   Simonsick, Eleanor M.
   Bauer, Douglas C.
   Boudreau, Robert
   Donohue, Julie M.
   Perera, Subashan
CA Hlth Aging & Body Composition Stud
TI Gastroprotective Agent Underuse in High-Risk Older Daily Nonsteroidal
   Anti-Inflammatory Drug Users over Time
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE nonsteroidal anti-inflammatory drug; older adults; gastroprotection
ID COX-2 INHIBITORS; NSAIDS; CARE; OSTEOARTHRITIS; PREVENTION; ELDERS
AB ObjectivesTo examine whether older adults taking nonsteroidal anti-inflammatory drugs (NSAIDs) decreased the underuse of gastroprotective agents over time.
   DesignBefore-and-after study.
   SettingHealth, Aging and Body Composition Study.
   ParticipantsDaily users of a NSAID (prescription and over the counter (OTC)) at visits in 2002-03 (preperiod; n=404) and 2006-07 (postperiod; n=172). The sample had a meanstandard deviation age of 78.22.7 at the preperiod visit and 81.92.7 at the postperiod visit. The majority were white and female and had 12 or more years of education.
   MeasurementsUnderusers were defined as persons taking nonselective NSAIDs who were at risk of peptic ulcer disease (PUD; because of current warfarin or glucocorticoid use or history of PUD) and not using a proton pump inhibitor (PPI) or persons taking cyclooxygenase 2 (COX-2) selective NSAIDs and aspirin who were at risk of PUD (having at least one risk factor) and not using a PPI.
   ResultsDaily NSAID use decreased from 17.6% to 11.3% (P<.001), and gastroprotective agent underuse decreased from 23.5% to 15.1% (P=.008). Controlling for important covariates, having prescription insurance was somewhat protective against underuse in the preperiod (adjusted odds ratio (AOR)=0.78, 95% confidence interval (CI)=0.46-1.34; P=.37), but more so and significantly in the postperiod (AOR=0.41, 95% CI=0.18-0.93; P=.03). Having prescription insurance was more protective in the post- than in the preperiod (less gastroprotective agent underuse; adjusted ratio of OR=0.53, 95% CI=0.22-1.29; P=.16), but this increased protection was not statistically significant.
   ConclusionIn older daily NSAID users at high risk of PUD, having prescription insurance and adequate gastroprotective use was more common in the post- than in the preperiod.
C1 [Marcum, Zachary A.; Hanlon, Joseph T.; Newman, Anne B.; Perera, Subashan] Univ Pittsburgh, Div Geriatr Med, Sch Med, Pittsburgh, PA 15213 USA.
   [Hanlon, Joseph T.] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15213 USA.
   [Hanlon, Joseph T.; Strotmeyer, Elsa S.; Newman, Anne B.; Boudreau, Robert] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA.
   [Hanlon, Joseph T.] Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equity Res, Pittsburgh, PA USA.
   [Hanlon, Joseph T.] Vet Affairs Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA.
   [Shorr, Ronald I.] Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Gainesville, FL 32608 USA.
   [Simonsick, Eleanor M.] NIA, Intramural Res Program, Baltimore, MD 21224 USA.
   [Bauer, Douglas C.] Univ Calif San Francisco, Sch Med, Dept Med, Div Gen Internal Med, San Francisco, CA USA.
   [Boudreau, Robert; Perera, Subashan] Univ Pittsburgh, Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15213 USA.
   [Donohue, Julie M.] Univ Pittsburgh, Sch Publ Hlth, Dept Hlth Policy & Management, Pittsburgh, PA 15213 USA.
RP Marcum, ZA (reprint author), Univ Pittsburgh, Div Geriatr Med, Sch Med, 3471 Fifth Ave,Suite 500, Pittsburgh, PA 15213 USA.
EM zam12@pitt.edu
RI Newman, Anne/C-6408-2013; 
OI Newman, Anne/0000-0002-0106-1150; Strotmeyer, Elsa/0000-0002-4093-6036;
   Boudreau, Robert/0000-0003-0162-5187; Donohue, Julie/0000-0003-2418-6017
FU Intramural NIH HHS; NIA NIH HHS [R01 AG027017, K07 AG033174,
   K07AG033174, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, P30 AG024827,
   P30AG024827, R01 AG028050, R01AG027017, R01AG028050, T32 AG021885]; NINR
   NIH HHS [R01 NR012459]
NR 19
TC 3
Z9 3
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD OCT
PY 2014
VL 62
IS 10
BP 1923
EP 1927
DI 10.1111/jgs.13066
PG 5
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA AS6QA
UT WOS:000344386400015
PM 25284702
ER

PT J
AU Malik, SM
   Pazdur, R
   Abrams, JS
   Socinski, MA
   Sause, WT
   Harpole, DH
   Welch, JJ
   Korn, EL
   Ullmann, CD
   Hirsch, FR
AF Malik, Shakun M.
   Pazdur, Richard
   Abrams, Jeffrey S.
   Socinski, Mark A.
   Sause, William T.
   Harpole, David H., Jr.
   Welch, John J.
   Korn, Edward L.
   Ullmann, Claudio Dansky
   Hirsch, Fred R.
TI Consensus Report of a Joint NCI Thoracic Malignancies Steering
   Committee: FDA Workshop on Strategies for Integrating Biomarkers into
   Clinical Development of New Therapies for Lung Cancer Leading to the
   Inception of "Master Protocols" in Lung Cancer
SO JOURNAL OF THORACIC ONCOLOGY
LA English
DT Article
DE NCI/FDA workshop leading to the Inception of "Master; Protocols" in Lung
   Cancer
ID GROWTH-FACTOR RECEPTOR; PHASE-III TRIAL; PREDICTIVE BIOMARKERS;
   GEFITINIB; ERLOTINIB; DESIGN; CHEMOTHERAPY; MUTATIONS; SURVIVAL;
   MULTICENTER
AB On February 2, 2012, the National Cancer Institute (NCI) sponsored a 2-day workshop with the NCI Thoracic Malignancies Steering Committee and the Food and Drug Administration to bring together leading academicians, clinicians, industry and government representatives to identify challenges and potential solutions in the clinical development of novel targeted therapies for lung cancer. Measures of success are rapidly evolving from a scientific and regulatory perspective and the objectives of this workshop were to achieve initial consensus on a high priority biomarker-driven clinical trial designed to rapidly assess the activity of targeted agents in molecularly defined lung cancer subsets and to facilitate generation of data leading to approval of these new therapies. Additionally, the meeting focused on identification of the barriers to conduct such a trial and the development of strategies to overcome those barriers. The "Lung Master Protocols" recently launched by NCI were the direct outcome of this workshop.
C1 [Malik, Shakun M.; Abrams, Jeffrey S.; Welch, John J.; Ullmann, Claudio Dansky] NCI, Clin Invest Branch, Canc Therapy Evaluat Program, NIH, Bethesda, MD 20850 USA.
   [Pazdur, Richard] US FDA, Off Hematol Prod, Ctr Drug Evaluat & Res, Silver Spring, MD USA.
   [Pazdur, Richard] US FDA, Off Oncol Prod, Ctr Drug Evaluat & Res, Silver Spring, MD USA.
   [Socinski, Mark A.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
   [Sause, William T.] Univ Utah, Salt Lake City, UT USA.
   [Harpole, David H., Jr.] Duke Univ, Med Ctr, Durham, NC USA.
   [Korn, Edward L.] NCI, Biometr Res Branch, Canc Therapy Evaluat Program, NIH, Bethesda, MD 20850 USA.
   [Hirsch, Fred R.] Univ Colorado, Sch Med, Denver, CO USA.
RP Malik, SM (reprint author), NCI, Canc Therapy Evaluat Program, NIH, Bethesda, MD 20850 USA.
EM shakun.malik@nih.gov
NR 32
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1556-0864
EI 1556-1380
J9 J THORAC ONCOL
JI J. Thorac. Oncol.
PD OCT
PY 2014
VL 9
IS 10
BP 1443
EP 1448
DI 10.1097/JTO.0000000000000314
PG 6
WC Oncology; Respiratory System
SC Oncology; Respiratory System
GA AS6IS
UT WOS:000344368000008
PM 25521397
ER

PT J
AU Ryan, BM
   Pine, SR
   Chaturvedi, AK
   Caporaso, N
   Harris, CC
AF Ryan, Brd M.
   Pine, Sharon R.
   Chaturvedi, Anil K.
   Caporaso, Neil
   Harris, Curtis C.
TI A Combined Prognostic Serum Interleukin-8 and Interleukin-6 Classifier
   for Stage 1 Lung Cancer in the Prostate, Lung, Colorectal, and Ovarian
   Cancer Screening Trial
SO JOURNAL OF THORACIC ONCOLOGY
LA English
DT Article
DE Stage 1; Prognosis; Inflammation; Lung cancer
ID C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; VINORELBINE PLUS
   CISPLATIN; JAPANESE POPULATION; MONONUCLEAR-CELLS; GROWTH-FACTOR;
   WEIGHT-LOSS; RISK; INFLAMMATION; SURVIVAL
AB Background: The advent of low-dose helical computed tomography for lung cancer screening will likely lead to an increase in the detection of stage I lung cancer. Presently, these patients are primarily treated with surgery alone and approximately 30% will develop recurrence and die. Biomarkers that can identify patients for whom adjuvant chemotherapy would be a benefit could significantly reduce both patient morbidity and mortality. Herein, we sought to build a prognostic inflammatory-based classifier for stage I lung cancer.
   Methods: We performed a retrospective analysis of 548 European American lung cancer cases prospectively enrolled in the Prostate, Lung, Colorectal and Ovarian study. C-reactive protein, interleukin (IL)-6, IL-8, tumor necrosis factor-alpha, and IL-1 beta were measured using an ultrasensitive electrochemiluminescence immunoassay in serum samples collected at the time of study entry.
   Results: IL-6 and IL-8 were each associated with significantly shorter survival (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.08-1.64; p = 0.007; and HR, 1.3; 95% CI, 1.09-1.67; p = 0.005, respectively). Moreover, a combined classifier of IL-6 and IL-8 were significantly associated with poor outcome in stage I lung cancer patients (HR, 3.39; 95% CI, 1.54-7.48, p = 0.002) and in stage 1 patients with more than or equal to 30 pack-years of smoking (HR, 3.15; 95% CI, 1.54-6.46, p = 0.002).
   Conclusions: These results further support the association between inflammatory markers and lung cancer outcome and suggest that a combined serum IL-6/IL-8 classifier could be a useful tool for guiding therapeutic decisions in patients with stage I lung cancer.
C1 [Ryan, Brd M.; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Pine, Sharon R.] Rutgers State Univ, Rutgers Canc Inst New Jersey, Dept Med, New Brunswick, NJ 08903 USA.
   [Chaturvedi, Anil K.] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
   [Caporaso, Neil] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.
RP Harris, CC (reprint author), NCI, Human Carcinogenesis Lab, Bldg 37,Room 3068,37 Convent Dr,MSC 4258, Bethesda, MD 20892 USA.
EM curtis_harris@nih.gov
RI Chaturvedi, Anil/J-2024-2015; 
OI Chaturvedi, Anil/0000-0003-2696-8899; Ryan, Brid/0000-0003-0038-131X
FU Intramural Research Program of the Center for Cancer Research, National
   Cancer Institute
FX This work was supported by the Intramural Research Program of the Center
   for Cancer Research, National Cancer Institute.
NR 57
TC 10
Z9 10
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1556-0864
EI 1556-1380
J9 J THORAC ONCOL
JI J. Thorac. Oncol.
PD OCT
PY 2014
VL 9
IS 10
BP 1494
EP 1503
DI 10.1097/JTO.0000000000000278
PG 10
WC Oncology; Respiratory System
SC Oncology; Respiratory System
GA AS6IS
UT WOS:000344368000015
PM 25170636
ER

PT J
AU He, JT
   Sun, XF
   Shi, TJ
   Schepmoes, AA
   Fillmore, TL
   Petyuk, VA
   Xie, F
   Zhao, R
   Gritsenko, MA
   Yang, F
   Kitabayashi, N
   Chae, SS
   Rubin, MA
   Siddiqui, J
   Wei, JT
   Chinnaiyan, AM
   Qian, WJ
   Smith, RD
   Kagan, J
   Srivastava, S
   Rodland, KD
   Liu, T
   Camp, DG
AF He, Jintang
   Sun, Xuefei
   Shi, Tujin
   Schepmoes, Athena A.
   Fillmore, Thomas L.
   Petyuk, Vladislav A.
   Xie, Fang
   Zhao, Rui
   Gritsenko, Marina A.
   Yang, Feng
   Kitabayashi, Naoki
   Chae, Sung-Suk
   Rubin, Mark A.
   Siddiqui, Javed
   Wei, John T.
   Chinnaiyan, Arul M.
   Qian, Wei-Jun
   Smith, Richard D.
   Kagan, Jacob
   Srivastava, Sudhir
   Rodland, Karin D.
   Liu, Tao
   Camp, David G., II
TI Antibody-independent targeted quantification of TMPRSS2-ERG fusion
   protein products in prostate cancer
SO MOLECULAR ONCOLOGY
LA English
DT Article
DE TMPRSS2-ERG gene fusion; ERG protein isoform; PRISM-SRM; Targeted
   quantification; Prostate cancer
ID ABSOLUTE QUANTIFICATION; TRANSCRIPTION FACTORS; MASS-SPECTROMETRY; GENE
   FUSIONS; PROTEOMICS; DISCOVERY; PLASMA; CELLS
AB Fusions between the transmembrane protease serine 2 (TMPRSS2) and ETS related gene (ERG) represent one of the most specific biomarkers that define a distinct molecular subtype of prostate cancer. Studies of TMPRSS2-ERG gene fusions have seldom been performed at the protein level, primarily due to the lack of high-quality antibodies suitable for quantitative studies. Herein, we applied a recently developed PRISM (high-pressure high-resolution separations with intelligent selection and multiplexing)-SRM (selected reaction monitoring) strategy for quantifying ERG protein in prostate cancer cell lines and tumors. The highly sensitive PRISM-SRM assays provided confident detection of 6 unique ERG peptides in both TMPRSS2-ERG positive cell lines and tissues, but not in cell lines or tissues lacking the TMPRSS2-ERG rearrangement, clearly indicating that ERG protein expression is significantly increased in the presence of the TMPRSS2ERG gene fusion. Significantly, our results provide evidence that two distinct ERG protein isoforms are simultaneously expressed in TMPRSS2-ERG positive samples as evidenced by the concomitant detection of two mutually exclusive peptides in two patient tumors and in the VCaP prostate cancer cell line. Three peptides, shared across almost all fusion protein products, were determined to be the most abundant peptides, providing "signature" peptides for detection of ERG over-expression resulting from TMPRSS2-ERG gene fusion. The PRISM-SRM assays provide valuable tools for studying TMPRSS2-ERG gene fusion protein products in prostate cancer. (C) 2014 Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies.
C1 [He, Jintang; Sun, Xuefei; Shi, Tujin; Schepmoes, Athena A.; Petyuk, Vladislav A.; Xie, Fang; Gritsenko, Marina A.; Yang, Feng; Qian, Wei-Jun; Smith, Richard D.; Rodland, Karin D.; Liu, Tao; Camp, David G., II] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA.
   [Fillmore, Thomas L.; Zhao, Rui] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA.
   [Kitabayashi, Naoki; Chae, Sung-Suk; Rubin, Mark A.] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA.
   [Siddiqui, Javed; Wei, John T.] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI USA.
   [Siddiqui, Javed; Chinnaiyan, Arul M.] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI USA.
   [Kagan, Jacob; Srivastava, Sudhir] NCI, Div Canc Prevent, Rockville, MD USA.
RP Liu, T (reprint author), Pacific NW Natl Lab, Div Biol Sci, POB 999,MSIN K8-98, Richland, WA 99352 USA.
EM tao.liu@pnnl.gov; dave.camp@pnnl.gov
RI Shi, Tujin/O-1789-2014; Smith, Richard/J-3664-2012; Wei,
   John/E-8967-2012; 
OI Smith, Richard/0000-0002-2381-2349; Petyuk,
   Vladislav/0000-0003-4076-151X; Rubin, Mark/0000-0002-8321-9950
FU National Cancer Institute (NCI) Early Detection Research Network
   Interagency Agreement [Y01-CN-05013-29]; National Institutes of Health
   [P41 GM103493]; Environmental Molecular Sciences Laboratory; Department
   of Energy and located at Pacific Northwest National Laboratory; Battelle
   Memorial Institute for the Department of Energy [DE-ACO5-76RL0 1830]
FX Portions of this work were supported by the National Cancer Institute
   (NCI) Early Detection Research Network Interagency Agreement
   Y01-CN-05013-29 (to K.D.R. and D.G.C.), and National Institutes of
   Health grant P41 GM103493 (to R.D.S.). The experimental work described
   herein was performed in the Environmental Molecular Sciences Laboratory,
   a national scientific user facility sponsored by the Department of
   Energy and located at Pacific Northwest National Laboratory, which is
   operated by Battelle Memorial Institute for the Department of Energy
   under Contract DE-ACO5-76RL0 1830.
NR 32
TC 5
Z9 5
U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1574-7891
EI 1878-0261
J9 MOL ONCOL
JI Mol. Oncol.
PD OCT
PY 2014
VL 8
IS 7
BP 1169
EP 1180
DI 10.1016/j.molonc.2014.02.004
PG 12
WC Oncology
SC Oncology
GA AS7KK
UT WOS:000344434900003
PM 25266362
ER

PT J
AU Abdel-Fatah, TMA
   Russell, R
   Albarakati, N
   Maloney, DJ
   Dorjsuren, D
   Rueda, OM
   Moseley, P
   Mohand, V
   Sun, HM
   Abbotts, R
   Mukherjee, A
   Agarwal, D
   Illuzzi, JL
   Jadhave, A
   Simeonov, A
   Ball, G
   Chan, S
   Caldas, C
   Ellis, IO
   Wilson, DM
   Madhusudan, S
AF Abdel-Fatah, Tarek M. A.
   Russell, Roslin
   Albarakati, Nada
   Maloney, David J.
   Dorjsuren, Dorjbal
   Rueda, Oscar M.
   Moseley, Paul
   Mohand, Vivek
   Sun, Hongmao
   Abbotts, Rachel
   Mukherjee, Abhik
   Agarwal, Devika
   Illuzzi, Jennifer L.
   Jadhave, Ajit
   Simeonov, Anton
   Ball, Graham
   Chan, Stephen
   Caldas, Carlos
   Ellis, Ian O.
   Wilson, David M., III
   Madhusudan, Srinivasan
TI Genomic and protein expression analysis reveals flap endonuclease 1
   (FEN1) as a key biomarker in breast and ovarian cancer
SO MOLECULAR ONCOLOGY
LA English
DT Article
DE FEN1; Breast cancer; Prognostic factor; Predictive factor; Drug target
ID GENE-EXPRESSION; GASTRIC-CANCER; LUNG-CANCER; MUTANT MICE; PERSONALIZED
   THERAPY; TUMOR PROGRESSION; PREDICTS RESPONSE; ADJUVANT THERAPY;
   ESTROGEN; CELLS
AB FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and have clinicopathological significance in patients. We comprehensively investigated FEN1 mRNA expression in multiple cohorts of breast cancer [training set (128), test set (249), external validation (1952)]. FEN1 protein expression was evaluated in 568 oestrogen receptor (ER) negative breast cancers, 894 ER positive breast cancers and 156 ovarian epithelial cancers. FEN1 mRNA overexpression was highly significantly associated with high grade (p = 4.89 x 10(-57)), high mitotic index (p = 5.25 x 10(-28)), pleomorphism (p = 6.31 x 10(-19)), ER negative (p = 9.02 x 10(-35)), PR negative (p = 9.24 x 10(-24)), triple negative phenotype (p = 6.67 x 10(-21)), PAM50.Her2 (p = 5.19 x 10(-13)), PAM50. Basal (p = 2.7 x 10(-41)), PAM50.LumB (p = 1.56 x 10(-26)), integrative molecular cluster 1 (intClust.1) (p = 7.47 x 10(-12)), intClust.5 (p = 4.05 x 10(-12)) and intClust. 10 (p = 7.59 x 10(-38)) breast cancers. FEN1 mRNA overexpression is associated with poor breast cancer specific survival in univariate (p = 4.4 x 10(-16)) and multivariate analysis (p = 9.19 x 10(-7)). At the protein level, in ER positive tumours, FEN1 overexpression remains significantly linked to high grade, high mitotic index and pleomorphism (ps < 0.01). In ER negative tumours, high FEN1 is significantly associated with pleomorphism, tumour type, lymphovascular invasion, triple negative phenotype, EGFR and HER2 expression (ps < 0.05). In ER positive as well as in ER negative tumours, FEN1 protein overexpression is associated with poor survival in univariate and multivariate analysis (ps < 0.01). In ovarian epithelial cancers, similarly, FEN1 overexpression is associated with high grade, high stage and poor survival (ps < 0.05). We conclude that FEN1 is a promising biomarker in breast and ovarian epithelial cancer. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 [Abdel-Fatah, Tarek M. A.; Moseley, Paul; Chan, Stephen; Madhusudan, Srinivasan] Univ Nottingham Hosp, Dept Oncol, Nottingham NG5 1PB, England.
   [Russell, Roslin; Rueda, Oscar M.; Caldas, Carlos] Univ Cambridge, Dept Oncol, Cambridge CB2 2XZ, England.
   [Russell, Roslin; Rueda, Oscar M.; Caldas, Carlos] Canc Res UK, Li Ka Shing Ctr, Cambridge Res Inst, Cambridge CB2 0RE, England.
   [Albarakati, Nada; Mohand, Vivek; Abbotts, Rachel; Madhusudan, Srinivasan] Univ Nottingham, Sch Med, Div Canc & Stem Cells, Acad Unit Oncol, Nottingham NG5 1PB, England.
   [Maloney, David J.; Dorjsuren, Dorjbal; Sun, Hongmao; Jadhave, Ajit; Simeonov, Anton] NIH Chem Genom Ctr, Natl Ctr Adv Translat Sci, NIH, Rockville, MD 20850 USA.
   [Mukherjee, Abhik] Univ Nottingham, Sch Med, Univ Nottingham Hosp, Dept Pathol,Div Canc & Stem Cells, Nottingham NG5 1PB, England.
   [Agarwal, Devika; Ball, Graham; Ellis, Ian O.] Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS, England.
   [Illuzzi, Jennifer L.; Wilson, David M., III] NIA, Lab Mol Gerontol, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.
RP Madhusudan, S (reprint author), Univ Nottingham, Sch Med, Univ Nottingham Hosp, Acad Unit Oncol,Div Canc & Stem Cells, Nottingham NG5 1PB, England.
EM srinivasan.madhusudan@nottingham.ac.uk
OI Agarwal, Devika/0000-0002-5203-307X; Madhusudan,
   Srinivasan/0000-0002-5354-5480
FU NIH grant [1 R03 MH092154-01]; Intramural Research Program of the
   National Institute on Aging, NIH; Molecular Libraries Common Fund
   Program of the NIH; National Center for Advancing Translational Sciences
   (USA); University of Nottingham and Nottingham University Hospitals
   Charity (UK); Medical Research Council, UK
FX Funding: This work was supported in part by an NIH grant to DMWIII (1
   R03 MH092154-01) and the Intramural Research Program of the National
   Institute on Aging, NIH, Molecular Libraries Common Fund Program of the
   NIH, National Center for Advancing Translational Sciences (USA),
   University of Nottingham and Nottingham University Hospitals Charity
   (UK). RA supported by the Medical Research Council, UK.
NR 39
TC 15
Z9 17
U1 1
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1574-7891
EI 1878-0261
J9 MOL ONCOL
JI Mol. Oncol.
PD OCT
PY 2014
VL 8
IS 7
BP 1326
EP 1338
DI 10.1016/j.molonc.2014.04.009
PG 13
WC Oncology
SC Oncology
GA AS7KK
UT WOS:000344434900015
PM 24880630
ER

PT J
AU Benyamin, B
   Esko, T
   Ried, JS
   Radhakrishnan, A
   Vermeulen, SH
   Traglia, M
   Gogele, M
   Anderson, D
   Broer, L
   Podmore, C
   Luan, JA
   Kutalik, Z
   Sanna, S
   van der Meer, P
   Tanaka, T
   Wang, FD
   Westra, HJ
   Franke, L
   Mihailov, E
   Milani, L
   Haldin, J
   Winkelmann, J
   Meitinger, T
   Thiery, J
   Peters, A
   Waldenberger, M
   Rendon, A
   Jolley, J
   Sambrook, J
   Kiemeney, LA
   Sweep, FC
   Sala, CF
   Schwienbacher, C
   Pichler, I
   Hui, J
   Demirkan, A
   Isaacs, A
   Amin, N
   Steri, M
   Waeber, G
   Verweij, N
   Powell, JE
   Nyholt, DR
   Heath, AC
   Madden, PAF
   Visscher, PM
   Wright, MJ
   Montgomery, GW
   Martin, NG
   Hernandez, D
   Bandinelli, S
   van der Harst, P
   Uda, M
   Vollenweider, P
   Scott, RA
   Langenberg, C
   Wareham, NJ
   van Duijn, C
   Beilby, J
   Pramstaller, PP
   Hicks, AA
   Ouwehand, WH
   Oexle, K
   Gieger, C
   Metspalu, A
   Camaschella, C
   Toniolo, D
   Swinkels, DW
   Whitfield, JB
AF Benyamin, Beben
   Esko, Tonu
   Ried, Janina S.
   Radhakrishnan, Aparna
   Vermeulen, Sita H.
   Traglia, Michela
   Goegele, Martin
   Anderson, Denise
   Broer, Linda
   Podmore, Clara
   Luan, Jian'an
   Kutalik, Zoltan
   Sanna, Serena
   van der Meer, Peter
   Tanaka, Toshiko
   Wang, Fudi
   Westra, Harm-Jan
   Franke, Lude
   Mihailov, Evelin
   Milani, Lili
   Haeldin, Jonas
   Winkelmann, Juliane
   Meitinger, Thomas
   Thiery, Joachim
   Peters, Annette
   Waldenberger, Melanie
   Rendon, Augusto
   Jolley, Jennifer
   Sambrook, Jennifer
   Kiemeney, Lambertus A.
   Sweep, Fred C.
   Sala, Cinzia F.
   Schwienbacher, Christine
   Pichler, Irene
   Hui, Jennie
   Demirkan, Ayse
   Isaacs, Aaron
   Amin, Najaf
   Steri, Maristella
   Waeber, Gerard
   Verweij, Niek
   Powell, Joseph E.
   Nyholt, Dale R.
   Heath, Andrew C.
   Madden, Pamela A. F.
   Visscher, Peter M.
   Wright, Margaret J.
   Montgomery, Grant W.
   Martin, Nicholas G.
   Hernandez, Dena
   Bandinelli, Stefania
   van der Harst, Pim
   Uda, Manuela
   Vollenweider, Peter
   Scott, Robert A.
   Langenberg, Claudia
   Wareham, Nicholas J.
   van Duijn, Cornelia
   Beilby, John
   Pramstaller, Peter P.
   Hicks, Andrew A.
   Ouwehand, Willem H.
   Oexle, Konrad
   Gieger, Christian
   Metspalu, Andres
   Camaschella, Clara
   Toniolo, Daniela
   Swinkels, Dorine W.
   Whitfield, John B.
CA InterAct Consortium
TI Novel loci affecting iron homeostasis and their effects in individuals
   at risk for hemochromatosis
SO NATURE COMMUNICATIONS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; TRANSFERRIN RECEPTOR 2; HFE HEREDITARY
   HEMOCHROMATOSIS; CORONARY-ARTERY-DISEASE; FOAM CELL-FORMATION;
   CIRCADIAN-RHYTHM; GENETIC-VARIANTS; COMMON VARIANTS; TOTAL MORTALITY;
   FERRITIN LEVELS
AB Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P < 5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease.
C1 [Benyamin, Beben; Visscher, Peter M.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
   [Benyamin, Beben; Nyholt, Dale R.; Wright, Margaret J.; Montgomery, Grant W.; Martin, Nicholas G.; Whitfield, John B.] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
   [Esko, Tonu; Mihailov, Evelin; Milani, Lili; Haeldin, Jonas; Metspalu, Andres] Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
   [Esko, Tonu] MIT, Broad Inst, Cambridge, MA 02141 USA.
   [Esko, Tonu] Harvard Univ, Cambridge, MA 02141 USA.
   [Ried, Janina S.; Gieger, Christian] Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany.
   [Radhakrishnan, Aparna; Rendon, Augusto; Jolley, Jennifer; Sambrook, Jennifer; Ouwehand, Willem H.] Univ Cambridge, Dept Haematol, Cambridge CB2 0XY, England.
   [Vermeulen, Sita H.] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, NL-6525 GA Nijmegen, Netherlands.
   [Vermeulen, Sita H.] Radboud Univ Nijmegen, Med Ctr, Dept Genet, NL-6525 GA Nijmegen, Netherlands.
   [Traglia, Michela; Toniolo, Daniela] Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy.
   [Traglia, Michela] IRCCS Burlo Garofolo Trieste, Inst Maternal & Child Health, I-34137 Trieste, Italy.
   [Goegele, Martin; Schwienbacher, Christine; Pichler, Irene; Hicks, Andrew A.] European Acad Bolzano Bozen EURAC, Ctr Biomed, I-39100 Bolzano, Italy.
   [Anderson, Denise; Isaacs, Aaron] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6872, Australia.
   [Broer, Linda; van Duijn, Cornelia] Erasmus MC, Dept Epidemiol, Subdiv Genet Epidemiol, NL-3000 CA Rotterdam, Netherlands.
   [Broer, Linda] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands.
   [Podmore, Clara; Luan, Jian'an; Langenberg, Claudia; Wareham, Nicholas J.] Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
   [Kutalik, Zoltan] CHU Vaudois, Inst Social & Prevent Med IUMSP, CH-1010 Lausanne, Switzerland.
   [Kutalik, Zoltan] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland.
   [Sanna, Serena; Steri, Maristella; Uda, Manuela] CNR, IRGB, I-09042 Cagliari, Italy.
   [van der Meer, Peter; Verweij, Niek; van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands.
   [Tanaka, Toshiko] NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA.
   [Wang, Fudi; Waldenberger, Melanie] Zhejiang Univ, Sch Publ Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
   [Westra, Harm-Jan; Franke, Lude] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands.
   [Mihailov, Evelin] Univ Tartu, Inst Mol & Cell Biol, EE-51010 Tartu, Estonia.
   [Winkelmann, Juliane] Stanford Univ, Dept Neurol & Neurosc, Palo Alto, CA 94304 USA.
   [Winkelmann, Juliane] Stanford Univ, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
   [Winkelmann, Juliane] Tech Univ Munich, Klinikum Rechts Isar, Neurol Klin & Poliklin, D-81675 Munich, Germany.
   [Winkelmann, Juliane; Meitinger, Thomas] Helmholtz Zentrum Munchen, Inst Humangenet, D-85764 Neuherberg, Germany.
   [Winkelmann, Juliane] Munich Cluster Syst Neurol SyNergy, D-81675 Munich, Germany.
   [Meitinger, Thomas; Oexle, Konrad] Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, D-81675 Munich, Germany.
   [Thiery, Joachim] Univ Klinikum Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany.
   [Thiery, Joachim] Univ Leipzig, Fac Med, LIFE Res Ctr Civilizat Dis, D-04103 Leipzig, Germany.
   [Peters, Annette; Gieger, Christian] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
   [Peters, Annette; Waldenberger, Melanie; Gieger, Christian] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany.
   [Rendon, Augusto; Jolley, Jennifer; Sambrook, Jennifer] NHS Blood & Transplant, Cambridge, England.
   [Rendon, Augusto] MRC, Biostat Unit, Cambridge CB2 0SR, England.
   [Kiemeney, Lambertus A.] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 GA Nijmegen, Netherlands.
   [Sweep, Fred C.; Swinkels, Dorine W.] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Lab Genet Endocrine & Metab Dis LGEM, NL-6525 GA Nijmegen, Netherlands.
   [Sala, Cinzia F.] Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy.
   [Hui, Jennie] PathWest Lab Med WA, Nedlands, WA 6009, Australia.
   [Hui, Jennie] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia.
   [Hui, Jennie] Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia.
   [Demirkan, Ayse] Leiden Univ, Med Ctr, Dept Human Genet, NL-2300 RC Leiden, Netherlands.
   [Isaacs, Aaron] Ctr Med Syst Biol, NL-2333 ZC Leiden, Netherlands.
   [Waeber, Gerard; Vollenweider, Peter] Univ Lausanne, CHUV, Dept Med, CH-1011 Lausanne, Switzerland.
   [Powell, Joseph E.; Visscher, Peter M.] Univ Queensland, Princess Alexandra Hosp, Diamantina Inst, Brisbane, Qld 4072, Australia.
   [Heath, Andrew C.; Madden, Pamela A. F.] Washington Univ, Dept Psychiat, St Louis, MO 63110 USA.
   [Hernandez, Dena] NIA, Neurogenet Lab, Bethesda, MD 20892 USA.
   [Bandinelli, Stefania] ASF, Geriatr Unit, I-50122 Florence, Italy.
   [van der Harst, Pim] ICIN Netherlands, Durrer Ctr Cardiogenet Res, Inst Heart, NL-3511 GC Utrecht, Netherlands.
   [van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands.
   [Pramstaller, Peter P.] Gen Cent Hosp, Dept Neurol, I-39100 Bolzano, Italy.
   [Camaschella, Clara] Univ Vita Salute San Raffaele, I-20132 Milan, Italy.
RP Whitfield, JB (reprint author), QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
EM John.Whitfield@qimrberghofer.edu.au
RI Hicks, Andrew/E-9518-2017; Deloukas, Panos/B-2922-2013; Franke,
   Lude/P-7036-2016; Swinkels, D.W./H-8098-2014; Kiemeney,
   Lambertus/D-3357-2009; Colaus, PsyColaus/K-6607-2013; Verweij,
   Niek/A-4499-2017; Grioni, Sara/K-5320-2016; Sweep, C.G.J./H-8096-2014;
   Montgomery, Grant/B-7148-2008; Meitinger, Thomas/O-1318-2015; Wright,
   Margaret/A-4560-2016; Peters, Annette/A-6117-2011; Vermeulen,
   H.H.M./L-4716-2015; 
OI Hicks, Andrew/0000-0001-6320-0411; Radhakrishnan,
   Aparna/0000-0002-8153-9037; Podmore, Clara/0000-0002-2452-8067; Esko,
   Tonu/0000-0003-1982-6569; Rendon, Augusto/0000-0001-8994-0039; Steri,
   Anna Maristella/0000-0001-5869-3872; Winkelmann,
   Juliane/0000-0003-2667-9691; Gieger, Christian/0000-0001-6986-9554;
   Franks, Paul/0000-0002-0520-7604; Verweij, Niek/0000-0002-4303-7685;
   Sacerdote, Carlotta/0000-0002-8008-5096; Forouhi,
   Nita/0000-0002-5041-248X; Deloukas, Panos/0000-0001-9251-070X; Franke,
   Lude/0000-0002-5159-8802; Kiemeney, Lambertus/0000-0002-2368-1326;
   Grioni, Sara/0000-0002-5891-8426; Montgomery, Grant/0000-0002-4140-8139;
   Wright, Margaret/0000-0001-7133-4970; Visscher,
   Peter/0000-0002-2143-8760; Ouwehand, Willem/0000-0002-7744-1790;
   Benyamin, Beben/0000-0001-5608-2293; Martin,
   Nicholas/0000-0003-4069-8020; Schulze, Matthias B./0000-0002-0830-5277
FU Australian National Health and Medical Research Council (NHMRC) training
   fellowship [552498]
FX B.B. was funded by an Australian National Health and Medical Research
   Council (NHMRC) training fellowship (552498). There was no specific
   funding for the meta-analysis, and sources of funding for the
   contributing studies are listed in Supplementary Table 1. We acknowledge
   the important work of the investigators of the Hemochromatosis and Iron
   Overload Screening Study (HEIRS), and the data and DNA from that study
   made available to us by the US National Institutes of Health through the
   Biologic Specimen and Data Repository Information Coordinating Center
   (BioLINCC). Information on membership of The InterAct Consortium is
   provided in Supplementary Note 1.
NR 69
TC 21
Z9 21
U1 3
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 4926
DI 10.1038/ncomms5926
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AR9YS
UT WOS:000343934300001
PM 25352340
ER

PT J
AU Lindstrom, S
   Thompson, DJ
   Paterson, AD
   Li, JM
   Gierach, GL
   Scott, C
   Stone, J
   Douglas, JA
   Dos-Santos-Silva, I
   Fernandez-Navarro, P
   Verghase, J
   Smith, P
   Brown, J
   Luben, R
   Wareham, NJ
   Loos, RJF
   Heit, JA
   Pankratz, VS
   Norman, A
   Goode, EL
   Cunningham, JM
   Deandrade, M
   Vierkant, RA
   Czene, K
   Fasching, PA
   Baglietto, L
   Southey, MC
   Giles, GG
   Shah, KP
   Chan, HP
   Helvie, MA
   Beck, AH
   Knoblauch, NW
   Hazra, A
   Hunter, DJ
   Kraft, P
   Pollan, M
   Figueroa, JD
   Couch, FJ
   Hopper, JL
   Hall, P
   Easton, DF
   Boyd, NF
   Vachon, CM
   Tamimi, RM
AF Lindstroem, Sara
   Thompson, Deborah J.
   Paterson, Andrew D.
   Li, Jingmei
   Gierach, Gretchen L.
   Scott, Christopher
   Stone, Jennifer
   Douglas, Julie A.
   dos-Santos-Silva, Isabel
   Fernandez-Navarro, Pablo
   Verghase, Jajini
   Smith, Paula
   Brown, Judith
   Luben, Robert
   Wareham, Nicholas J.
   Loos, Ruth J. F.
   Heit, John A.
   Pankratz, V. Shane
   Norman, Aaron
   Goode, Ellen L.
   Cunningham, Julie M.
   Deandrade, Mariza
   Vierkant, Robert A.
   Czene, Kamila
   Fasching, Peter A.
   Baglietto, Laura
   Southey, Melissa C.
   Giles, Graham G.
   Shah, Kaanan P.
   Chan, Heang-Ping
   Helvie, Mark A.
   Beck, Andrew H.
   Knoblauch, Nicholas W.
   Hazra, Aditi
   Hunter, David J.
   Kraft, Peter
   Pollan, Marina
   Figueroa, Jonine D.
   Couch, Fergus J.
   Hopper, John L.
   Hall, Per
   Easton, Douglas F.
   Boyd, Norman F.
   Vachon, Celine M.
   Tamimi, Rulla M.
TI Genome-wide association study identifies multiple loci associated with
   both mammographic density and breast cancer risk
SO NATURE COMMUNICATIONS
LA English
DT Article
ID SUSCEPTIBILITY LOCI; VARIANTS; HERITABILITY; METAANALYSIS; PEDIGREES;
   LINKAGE
AB Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies GWAS) of three mammographic density phenotypes: dense area, non-dense area and percent density in up to 7,916 women in stage 1 and an additional 10,379 women in stage 2. We identify genome-wide significant (P<5 x 10(-8)) loci for dense area AREG, ESR1, ZNF365, LSP1/TNNT3, IGF1, TMEM184B and SGSM3/MKL1), non-dense area (8p11.23) and percent density PRDM6, 8p11.23 and TMEM184B). Four of these regions are known breast cancer susceptibility loci, and four additional regions were found to be associated with breast cancer (P<0.05) in a large meta-analysis. These results provide further evidence of a shared genetic basis between mammographic density and breast cancer and illustrate the power of studying intermediate quantitative phenotypes to identify putative disease-susceptibility loci.
C1 [Lindstroem, Sara; Hazra, Aditi; Hunter, David J.; Kraft, Peter; Tamimi, Rulla M.] Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA.
   [Lindstroem, Sara; Hazra, Aditi; Hunter, David J.; Kraft, Peter; Tamimi, Rulla M.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Thompson, Deborah J.; Verghase, Jajini; Smith, Paula; Brown, Judith; Luben, Robert; Easton, Douglas F.] Univ Cambridge, Ctr Genet Epidemiol, Cambridge CB1 8RN, England.
   [Thompson, Deborah J.; Verghase, Jajini; Smith, Paula; Brown, Judith; Easton, Douglas F.] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.
   [Paterson, Andrew D.] Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, Canada.
   [Li, Jingmei; Czene, Kamila; Hall, Per] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.
   [Gierach, Gretchen L.; Figueroa, Jonine D.] NCI, Hormonal & Reprod Epidemiol Branch, Bethesda, MD 20850 USA.
   [Scott, Christopher; Pankratz, V. Shane; Norman, Aaron; Goode, Ellen L.; Deandrade, Mariza; Vierkant, Robert A.; Couch, Fergus J.; Vachon, Celine M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.
   [Stone, Jennifer] Univ Western Australia, Ctr Genet Origins Hlth & Dis, Perth, WA 6009, Australia.
   [Douglas, Julie A.; Shah, Kaanan P.] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA.
   [dos-Santos-Silva, Isabel] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1E 7HT, England.
   [Fernandez-Navarro, Pablo; Pollan, Marina] Carlos III Inst Hlth, Canc & Environm Epidemiol Unit, Natl Ctr Epidemiol, Madrid 28029, Spain.
   [Fernandez-Navarro, Pablo; Pollan, Marina] CIBER Epidemiol & Salud Publ CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid 28029, Spain.
   [Verghase, Jajini] Royal Free Hosp, Plast Surg Unit, London NW3 2QG, England.
   [Wareham, Nicholas J.; Loos, Ruth J. F.] Univ Cambridge, Inst Metab Sci, Epidemiol Unit, MRC, Cambridge CB1 8RN, England.
   [Loos, Ruth J. F.] Mindich Child Hlth & Dev Inst, Charles Bronfman Inst Personalized Med, Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Heit, John A.] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Cunningham, Julie M.; Couch, Fergus J.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   [Fasching, Peter A.] Univ Erlangen Nurnberg, Comprehens Canc Ctr Erlangen EMN, Erlangen Univ Hosp, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.
   [Fasching, Peter A.] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Dept Med, Los Angeles, CA 90024 USA.
   [Baglietto, Laura; Giles, Graham G.] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3004, Australia.
   [Baglietto, Laura; Giles, Graham G.; Hopper, John L.] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic 3010, Australia.
   [Southey, Melissa C.] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia.
   [Chan, Heang-Ping; Helvie, Mark A.] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA.
   [Beck, Andrew H.; Knoblauch, Nicholas W.] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA.
   [Beck, Andrew H.; Knoblauch, Nicholas W.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Hazra, Aditi; Hunter, David J.; Tamimi, Rulla M.] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA.
   [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
   [Easton, Douglas F.] Univ Cambridge, Dept Oncol, Cambridge CB1 8RN, England.
   [Boyd, Norman F.] Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2M9, Canada.
RP Tamimi, RM (reprint author), Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 665 Huntington Ave, Boston, MA 02115 USA.
EM rulla.tamimi@channing.harvard.edu
RI Li, Jingmei/I-2904-2012; Paterson, Andrew/A-4088-2011; Gierach,
   Gretchen/E-1817-2016; 
OI Li, Jingmei/0000-0001-8587-7511; Paterson, Andrew/0000-0002-9169-118X;
   Gierach, Gretchen/0000-0002-0165-5522; Czene,
   Kamila/0000-0002-3233-5695; Luben, Robert/0000-0002-5088-6343; dos
   Santos Silva, Isabel/0000-0002-6596-8798
FU NIH [CA131332, CA087969, CA049449, CA128931, CA116201, CA075016,
   CA122340, CA122844, CA15083, CA089393, K22LM011931, X01 HG005954];
   Center for Inherited Disease Research (CIDR) - National Institutes of
   Health [HHSN268200782096]; Breast Cancer Research Foundation, Breast
   Cancer Research Fund; Cancer Research UK; Marit & Hans Rausing's
   Initiative against Breast Cancer; Susan Komen Foundation; Agency for
   Science, Technology and Research of Singapore (A*STAR); David F. and
   Margaret T. Grohne Family Foundation; Campbell Family Institute for
   Breast Cancer Research; Ontario Ministry of Health and Long Term Care;
   Fashion Footwear Charitable Foundation of New York/QVC Presents Shoes on
   Sale; FIS from the Spain's Health Research Fund [PI060386]; Astra-Zeneca
   [EPY 1306/06]; Carlos III Institute of Health [EPY 1306/06]; Elizabeth
   C. Crosby Research Award; Gladys E. Davis Endowed Fund; Office for Vice
   President of Research at the University of Michigan; Medical Research
   Council; Stroke Association; British Heart Foundation; Department of
   Health; Research into Ageing; Academy of Medical Sciences; Cancer
   Research UK [C1287/A10118, C1287/8459, C490/A10124, C1287/A 10710,
   C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692];
   National Institutes of Health, National Cancer Institute; GAME-ON DRIVE
   [CA148065]; BCAC initiatives; Medical Faculty, Friedrich-Alexander
   University Erlangen-Nuremberg; European Community [223175
   (HEALTH-F2-2009-223175)]; National Institutes of Health [CA128978];
   Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19
   CA148112]; Department of Defence [W81XWH-10-1-0341]; Canadian Institutes
   of Health Research (CIHR); Komen Foundation for the Cure; Breast Cancer
   Research Foundation; Ovarian Cancer Research Fund
FX This study was supported by CA131332, CA087969, CA049449, CA128931,
   CA116201, CA075016, CA122340, CA122844, CA15083, CA089393, K22LM011931
   and X01 HG005954 from NIH; genotyping services for the OOA study were
   provided by the Center for Inherited Disease Research (CIDR), which is
   fully funded through a federal contract from the National Institutes of
   Health to The Johns Hopkins University, contract number
   HHSN268200782096; The Breast Cancer Research Foundation, Breast Cancer
   Research Fund; Cancer Research UK; Marit & Hans Rausing's Initiative
   against Breast Cancer; Susan Komen Foundation; Agency for Science,
   Technology and Research of Singapore (A*STAR); David F. and Margaret T.
   Grohne Family Foundation; Campbell Family Institute for Breast Cancer
   Research; David F. and Margaret T. Grohne Family Foundation; Ontario
   Ministry of Health and Long Term Care; Fashion Footwear Charitable
   Foundation of New York/QVC Presents Shoes on Sale; FIS PI060386 from the
   Spain's Health Research Fund and EPY 1306/06 Collaboration Agreement
   between Astra-Zeneca and the Carlos III Institute of Health; Elizabeth
   C. Crosby Research Award, Gladys E. Davis Endowed Fund and the Office
   for Vice President of Research at the University of Michigan.
   EPIC-Norfolk was funded by research programme grant funding from Cancer
   Research UK and the Medical Research Council with additional support
   from the Stroke Association, British Heart Foundation, Department of
   Health, Research into Ageing and Academy of Medical Sciences. The SIBS
   study was supported by programme grant C1287/A10118 and project grants
   from Cancer Research UK (grant numbers C1287/8459). SEARCH is funded by
   a programme grant from Cancer Research UK (C490/A10124). The Polish
   Breast Cancer Study was supported (in part) by the Intramural Research
   Program of the National Institutes of Health, National Cancer Institute.
   The breast cancer meta-analysis is supported by the GAME-ON DRIVE
   (CA148065) and BCAC initiatives. We thank the BCAC, GAME-ON and DRIVE
   initiatives for generously sharing breast cancer association results for
   selected SNPs. We also thank the investigators in BCAC, PRACTICAL, CIMBA
   and OCAC for access to the iCOGS data for the replication analysis. BBCC
   was funded in part by the ELAN Programme of the Medical Faculty,
   Friedrich-Alexander University Erlangen-Nuremberg. We thank all the
   individuals who took part in these studies and all the researchers,
   clinicians, technicians and administrative staff who have enabled this
   work to be carried out. The OOA study investigators thank the members of
   the Amish community for their generous support and participation, the
   staff at the Amish Research Clinic for their dedicated recruitment and
   fieldwork efforts, the members of Dr Margarita Shultz's radiology clinic
   for their expert mammography services, the staff at the Center for
   Inherited Disease Research for their exceptional genotyping services,
   Drs Alan Shuldiner and Braxton Mitchell at the University of Maryland
   for their guidance and help with our fieldwork, and Terry Gliedt,
   Jennifer Greene Nidetz, Kristen Maas, Cris Van Hout, James MacDonald,
   Chris Plotts, Lubomir Hadjiiski and Chuan Zhou at the University of
   Michigan for their technical assistance with data management, entry and
   analysis and film digitization and scoring.; The PBCS would like to
   thank Pei Chao and Michael Stagner from Information Management Services
   (Silver Spring, MD) for data management support; Laurie Burdette, Amy
   Hutchinson and Jeff Yuenger from the NCI Core Genotyping facility for
   genotyping support; the participants, physicians, pathologists, nurses
   and interviewers from participating centres in Poland for their efforts
   during fieldwork; Drs Jola Lissowska and Ewa Wesolowska from the Maria
   Sklodowska-Curie Memorial Cancer Center and Institute of Oncology,
   Warsaw, Poland for their assistance with mammogram retrieval; Dr Norman
   Boyd from the University of Toronto for providing the mammographic
   density assessments; and Drs. Louise Brinton, Montserrat Garcia-Closas,
   Beata Peplonska and Mark Sherman for their contributions to the study
   design. We thank Paul Pharoah and the SEARCH and EPIC teams. The iCOGS
   project would not have been possible without the contributions of the
   following: Paul Pharoah, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang
   (BCAC), Andrew Berchuck (OCAC), Rosalind A. Eeles, Ali Amin Al Olama,
   Zsofia Kote-Jarai, Sara Benlloch (PRACTICAL), Georgia Chenevix-Trench,
   Antonis Antoniou, Lesley McGuffog and Ken Offit (CIMBA), Joe Dennis,
   Alison M. Dunning, Andrew Lee, and Ed Dicks, Craig Luccarini and the
   staff of the Centre for Genetic Epidemiology Laboratory, Javier Benitez,
   Anna Gonzalez-Neira and the staff of the CNIO genotyping unit, Jacques
   Simard and Daniel C. Tessier, Francois Bacot, Daniel Vincent, Sylvie
   LaBoissiere and Frederic Robidoux and the staff of the McGill University
   and Genome Quebec Innovation Centre, Stig E. Bojesen, Sune F. Nielsen,
   Borge G. Nordestgaard and the staff of the Copenhagen DNA laboratory,
   and Julie M. Cunningham, Sharon A. Windebank, Christopher A. Hilker,
   Jeffrey Meyer and the staff of Mayo Clinic Genotyping Core Facility. The
   iCOGS infrastructure was funded by the following: the European
   Community's Seventh Framework Programme under grant agreement no. 223175
   (HEALTH-F2-2009-223175; COGS), Cancer Research UK (C1287/A10118, C1287/A
   10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007,
   C5047/A10692), the National Institutes of Health (CA128978) and
   Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19
   CA148112-the GAME-ON initiative), the Department of Defence
   (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR)
   for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation
   for the Cure, the Breast Cancer Research Foundation and the Ovarian
   Cancer Research Fund. The results published here are in part based upon
   data generated by The Cancer Genome Atlas project established by the NCI
   and NHGRI (dbGaP Study Accession: phs000178.v8.p7). Information about
   TCGA and the investigators and institutions who constitute the TCGA
   research network can be found at http://cancergenome.nih.gov/.
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5303
DI 10.1038/ncomms6303
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS1SN
UT WOS:000344061500002
PM 25342443
ER

PT J
AU Maindola, P
   Raina, R
   Goyal, P
   Atmakuri, K
   Ojha, A
   Gupta, S
   Christie, PJ
   Iyer, LM
   Aravind, L
   Arockiasamy, A
AF Maindola, Priyank
   Raina, Rahul
   Goyal, Parveen
   Atmakuri, Krishnamohan
   Ojha, Abhishek
   Gupta, Sourabh
   Christie, Peter J.
   Iyer, Lakshminarayan M.
   Aravind, L.
   Arockiasamy, Arulandu
TI Multiple enzymatic activities of ParB/Srx superfamily mediate sexual
   conflict among conjugative plasmids
SO NATURE COMMUNICATIONS
LA English
DT Article
ID IV SECRETION SYSTEMS; SINGLE-STRANDED-DNA; AGROBACTERIUM-TUMEFACIENS
   ONCOGENICITY; VIRD2 PROTEIN; T-DNA; CHROMOSOME SEGREGATION; VIRE2
   PROTEIN; OSA GENE; BINDING; INHIBIT
AB Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts.
C1 [Maindola, Priyank; Raina, Rahul; Goyal, Parveen; Ojha, Abhishek; Gupta, Sourabh; Arockiasamy, Arulandu] Int Ctr Genet Engn & Biotechnol, Struct & Computat Biol Grp, New Delhi 110067, India.
   [Atmakuri, Krishnamohan; Christie, Peter J.] Univ Texas Houston, Med Sch Houston, Dept Microbiol & Mol Genet, Houston, TX 77030 USA.
   [Iyer, Lakshminarayan M.; Aravind, L.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
RP Arockiasamy, A (reprint author), Int Ctr Genet Engn & Biotechnol, Struct & Computat Biol Grp, Aruna Asaf Ali Marg, New Delhi 110067, India.
EM aravind@ncbi.nlm.nih.gov; sam@icgeb.res.in
RI goyal, parveen/J-8435-2014; 
OI goyal, parveen/0000-0002-7808-8298; Arulandu,
   Arockiasamy/0000-0002-4606-8006
FU DBT, India; CSIR fellowship; DBT fellowship; National Library of
   Medicine, NIH; NIH [R01GM48746]; DBT; ICGEB
FX We thank Amit Sharma and Sunil Mukherjee (ICGEB) for providing access to
   infrastructure, green house, plants and help with agroinfiltration,
   Nirupam Roy Choudary (ICGEB) for help with TLC experiments, K.
   Veluthambi and Hussain Munnavar (Madurai Kamaraj University) for
   Agrobacterium strains and plasmids and P1 genomic DNA, respectively,
   Derrick Crook (University of Oxford) for ICEHin1056 DNA, Bichitra K.
   Biswal and Ravikant Pal (National Institute of Immunology, New Delhi)
   for access to X-ray data collection facility, funded by DBT, India, S.
   Krishnaswamy (Madurai Kamaraj University), Anmol and Sujatha, (ICGEB)
   for suggestions and critical reading of the manuscript. P.M., P.G. and
   R.R. are supported by CSIR fellowship. A.O. and S.G. are supported by
   DBT fellowship. L.A. and L.M.I. are supported by funds of the intramural
   research programme of the National Library of Medicine, NIH. Work in the
   Christie laboratory is supported by NIH grant R01GM48746. A.A. is
   supported by funding from DBT (Basic Research in Modern Biology Task
   Force and Rapid Grant for Young Investigators) and ICGEB core fund.
NR 70
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U1 3
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5322
DI 10.1038/ncomms6322
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS1SR
UT WOS:000344061900002
PM 25358815
ER

PT J
AU Postmus, I
   Trompet, S
   Deshmukh, HA
   Barnes, MR
   Li, XH
   Warren, HR
   Chasman, DI
   Zhou, KX
   Arsenault, BJ
   Donnelly, LA
   Wiggins, KL
   Avery, CL
   Griffin, P
   Feng, QP
   Taylor, KD
   Li, G
   Evans, DS
   Smith, AV
   de Keyser, CE
   Johnson, AD
   de Craen, AJM
   Stott, DJ
   Buckley, BM
   Ford, I
   Westendorp, RGJ
   Slagboom, PE
   Sattar, N
   Munroe, PB
   Sever, P
   Poulter, N
   Stanton, A
   Shields, DC
   O'Brien, E
   Shaw-Hawkins, S
   Chen, YDI
   Nickerson, DA
   Smith, JD
   Dube, MP
   Boekholdt, SM
   Hovingh, GK
   Kastelein, JJP
   McKeigue, PM
   Betteridge, J
   Neil, A
   Durrington, PN
   Doney, A
   Carr, F
   Morris, A
   McCarthy, MI
   Groop, L
   Ahlqvist, E
   Bis, JC
   Rice, K
   Smith, NL
   Lumley, T
   Whitsel, EA
   Sturmer, T
   Boerwinkle, E
   Ngwa, JS
   O'Donnell, CJ
   Vasan, RS
   Wei, WQ
   Wilke, RA
   Liu, CT
   Sun, FG
   Guo, XQ
   Heckbert, SR
   Post, W
   Sotoodehnia, N
   Arnold, AM
   Stafford, JM
   Ding, JZ
   Herrington, DM
   Kritchevsky, SB
   Eiriksdottir, G
   Launer, LJ
   Harris, TB
   Chu, AY
   Giulianini, F
   MacFadyen, JG
   Barratt, BJ
   Nyberg, F
   Stricker, BH
   Uitterlinden, AG
   Hofman, A
   Rivadeneira, F
   Emilsson, V
   Franco, OH
   Ridker, PM
   Gudnason, V
   Liu, YM
   Denny, JC
   Ballantyne, CM
   Rotter, JI
   Cupples, LA
   Psaty, BM
   Palmer, CNA
   Tardif, JC
   Colhoun, HM
   Hitman, G
   Krauss, RM
   Jukema, JW
   Caulfield, MJ
AF Postmus, Iris
   Trompet, Stella
   Deshmukh, Harshal A.
   Barnes, Michael R.
   Li, Xiaohui
   Warren, Helen R.
   Chasman, Daniel I.
   Zhou, Kaixin
   Arsenault, Benoit J.
   Donnelly, Louise A.
   Wiggins, Kerri L.
   Avery, Christy L.
   Griffin, Paula
   Feng, QiPing
   Taylor, Kent D.
   Li, Guo
   Evans, Daniel S.
   Smith, Albert V.
   de Keyser, Catherine E.
   Johnson, Andrew D.
   de Craen, Anton J. M.
   Stott, David J.
   Buckley, Brendan M.
   Ford, Ian
   Westendorp, Rudi G. J.
   Slagboom, P. Eline
   Sattar, Naveed
   Munroe, Patricia B.
   Sever, Peter
   Poulter, Neil
   Stanton, Alice
   Shields, Denis C.
   O'Brien, Eoin
   Shaw-Hawkins, Sue
   Chen, Y. -D. Ida
   Nickerson, Deborah A.
   Smith, Joshua D.
   Dube, Marie Pierre
   Boekholdt, S. Matthijs
   Hovingh, G. Kees
   Kastelein, John J. P.
   McKeigue, Paul M.
   Betteridge, John
   Neil, Andrew
   Durrington, Paul N.
   Doney, Alex
   Carr, Fiona
   Morris, Andrew
   McCarthy, Mark I.
   Groop, Leif
   Ahlqvist, Emma
   Bis, Joshua C.
   Rice, Kenneth
   Smith, Nicholas L.
   Lumley, Thomas
   Whitsel, Eric A.
   Stuermer, Til
   Boerwinkle, Eric
   Ngwa, Julius S.
   O'Donnell, Christopher J.
   Vasan, Ramachandran S.
   Wei, Wei-Qi
   Wilke, Russell A.
   Liu, Ching-Ti
   Sun, Fangui
   Guo, Xiuqing
   Heckbert, Susan R.
   Post, Wendy
   Sotoodehnia, Nona
   Arnold, Alice M.
   Stafford, Jeanette M.
   Ding, Jingzhong
   Herrington, David M.
   Kritchevsky, Stephen B.
   Eiriksdottir, Gudny
   Launer, Leonore J.
   Harris, Tamara B.
   Chu, Audrey Y.
   Giulianini, Franco
   MacFadyen, Jean G.
   Barratt, Bryan J.
   Nyberg, Fredrik
   Stricker, Bruno H.
   Uitterlinden, Andre G.
   Hofman, Albert
   Rivadeneira, Fernando
   Emilsson, Valur
   Franco, Oscar H.
   Ridker, Paul M.
   Gudnason, Vilmundur
   Liu, Yongmei
   Denny, Joshua C.
   Ballantyne, Christie M.
   Rotter, Jerome I.
   Cupples, L. Adrienne
   Psaty, Bruce M.
   Palmer, Colin N. A.
   Tardif, Jean-Claude
   Colhoun, Helen M.
   Hitman, Graham
   Krauss, Ronald M.
   Jukema, J. Wouter
   Caulfield, Mark J.
CA Welcome Trust Case Control Consort
TI Pharmacogenetic meta-analysis of genome-wide association studies of LDL
   cholesterol response to statins
SO NATURE COMMUNICATIONS
LA English
DT Article
ID PLASMA LIPOPROTEIN(A) LEVELS; HUMAN PREFRONTAL CORTEX; GENE-EXPRESSION;
   WHOLE-GENOME; INDUCED MYOPATHY; DISEASE; LOCI; VARIANTS; THERAPY; BLOOD
AB Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
C1 [Postmus, Iris; Trompet, Stella; Westendorp, Rudi G. J.] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands.
   [Postmus, Iris; Westendorp, Rudi G. J.; Slagboom, P. Eline; Uitterlinden, Andre G.; Hofman, Albert] Netherlands Consortium Healthy Ageing, NL-2300 RC Leiden, Netherlands.
   [Trompet, Stella; Jukema, J. Wouter] Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands.
   [Deshmukh, Harshal A.; Zhou, Kaixin; Donnelly, Louise A.; Doney, Alex; Carr, Fiona; Morris, Andrew; Palmer, Colin N. A.; Colhoun, Helen M.] Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 9SY, Scotland.
   [Barnes, Michael R.; Shaw-Hawkins, Sue] Queen Mary Univ London, Genome Ctr, Barts & London Sch Med, William Harvey Res Inst, London EC1M 6BQ, England.
   [Barnes, Michael R.; Warren, Helen R.; Munroe, Patricia B.; Shaw-Hawkins, Sue; Caulfield, Mark J.] Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, London EC1M 6BQ, England.
   [Li, Xiaohui; Taylor, Kent D.; Chen, Y. -D. Ida; Guo, Xiuqing; Rotter, Jerome I.] Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA.
   [Warren, Helen R.; Munroe, Patricia B.; Caulfield, Mark J.] Queen Mary Univ London, Barts & London Sch Med, William Harvey Res Inst, Dept Clin Pharmacol, London EC1M 6BQ, England.
   [Chasman, Daniel I.; Chu, Audrey Y.; Giulianini, Franco; MacFadyen, Jean G.; Ridker, Paul M.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA.
   [Chasman, Daniel I.] Harvard Univ, Sch Med, Boston, MA 02215 USA.
   [Arsenault, Benoit J.; Dube, Marie Pierre; Tardif, Jean-Claude] Univ Montreal, Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.
   [Wiggins, Kerri L.; Li, Guo; de Craen, Anton J. M.; Bis, Joshua C.; Lumley, Thomas; Sotoodehnia, Nona; Psaty, Bruce M.] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.
   [Avery, Christy L.; Whitsel, Eric A.; Stuermer, Til] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA.
   [Griffin, Paula; Ngwa, Julius S.; Liu, Ching-Ti; Sun, Fangui; Cupples, L. Adrienne] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.
   [Feng, QiPing] Vanderbilt Univ, Dept Clin Pharmacol, Nashville, TN 37240 USA.
   [Evans, Daniel S.] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94107 USA.
   [Smith, Albert V.; Eiriksdottir, Gudny; Emilsson, Valur; Gudnason, Vilmundur] Iceland Heart Assoc, IS-201 Kopavogur, Iceland.
   [Smith, Albert V.; Gudnason, Vilmundur] Univ Iceland, IS-101 Reykjavik, Iceland.
   [de Keyser, Catherine E.; Uitterlinden, Andre G.; Hofman, Albert; Franco, Oscar H.] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
   [de Keyser, Catherine E.] Hlth Care Inspectorate, NL-2595 AN The Hague, Netherlands.
   [Johnson, Andrew D.] NHLBI, FHS, Framingham, MA 01702 USA.
   [Stott, David J.] Univ Glasgow, Fac Med, Inst Cardiovasc & Med Sci, Glasgow G31 2ER, Lanark, Scotland.
   [Buckley, Brendan M.] Natl Univ Ireland Univ Coll Cork, Dept Pharmacol & Therapeut, Cork 30, Ireland.
   [Ford, Ian] Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland.
   [Westendorp, Rudi G. J.] Leyden Acad Vital & Ageing, NL-2333 AA Leiden, Netherlands.
   [Slagboom, P. Eline] Leiden Univ, Med Ctr, Dept Mol Epidemiol, NL-2300 RC Leiden, Netherlands.
   [Sattar, Naveed] BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow G12 8QQ, Lanark, Scotland.
   [Sever, Peter; Poulter, Neil] Univ London Imperial Coll Sci Technol & Med, Int Ctr Circulatory Hlth, London SW7 2AZ, England.
   [Stanton, Alice] Royal Coll Surgeons Ireland, Dublin 2, Ireland.
   [Stanton, Alice] Beaumont Hosp, Dublin 9, Ireland.
   [Shields, Denis C.; O'Brien, Eoin] Univ Coll Dublin, Conway Inst, Dublin 4, Ireland.
   [Shields, Denis C.] Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland.
   [Nickerson, Deborah A.; Smith, Joshua D.] Univ Washington, Dept Genome Sci, Seattle, WA 98101 USA.
   [Boekholdt, S. Matthijs] Acad Med Ctr, Dept Cardiol, NL-1100 DD Amsterdam, Netherlands.
   [Hovingh, G. Kees; Kastelein, John J. P.] Acad Med Ctr, Dept Vasc Med, NL-1100 DD Amsterdam, Netherlands.
   [McKeigue, Paul M.] Univ Edinburgh, Edinburgh EH9 3JR, Midlothian, Scotland.
   [Betteridge, John] UCL, London WC1E 6BT, England.
   [Neil, Andrew] Univ Oxford, Oxford OX1 2JD, England.
   [Durrington, Paul N.] Univ Manchester, Sch Biosci, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England.
   [McCarthy, Mark I.] Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England.
   [McCarthy, Mark I.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
   [McCarthy, Mark I.] Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 7LJ, England.
   [Groop, Leif; Ahlqvist, Emma] Lund Univ, Dept Clin Sci Diabet & Endocrinol, S-20502 Malmo, Sweden.
   [Rice, Kenneth; Arnold, Alice M.] Univ Washington, Dept Biostat, Seattle, WA 98115 USA.
   [Smith, Nicholas L.; Psaty, Bruce M.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Smith, Nicholas L.; Psaty, Bruce M.] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA 98101 USA.
   [Smith, Nicholas L.] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Off Res & Dev, Seattle, WA 98101 USA.
   [Lumley, Thomas] Univ Auckland, Dept Stat, Auckland 1142, New Zealand.
   [Whitsel, Eric A.] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA.
   [Boerwinkle, Eric] Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.
   [O'Donnell, Christopher J.; Cupples, L. Adrienne] NHLBI Framingham Heart Study, Framingham, MA 01701 USA.
   [O'Donnell, Christopher J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Div Cardiol, Boston, MA 02115 USA.
   [O'Donnell, Christopher J.] NHLBI, Bethesda, MD 20892 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Dept Med, Sect Prevent Med & Epidemiol, Framingham, MA 01701 USA.
   [Vasan, Ramachandran S.] Framingham Heart Dis Epidemiol Study, Framingham, MA 01701 USA.
   [Wei, Wei-Qi; Denny, Joshua C.] Vanderbilt Univ, Dept Biomed Informat, Nashville, TN 37240 USA.
   [Wilke, Russell A.] Sanford Healthcare, Ctr IMAGENETICS, Dept Internal Med, Fargo, ND 58104 USA.
   [Heckbert, Susan R.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.
   [Post, Wendy] Johns Hopkins Univ, Dept Cardiol, Baltimore, MD 21218 USA.
   [Sotoodehnia, Nona] Univ Washington, Harborview Med Ctr, Div Cardiol, Seattle, WA 98101 USA.
   [Stafford, Jeanette M.] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
   [Ding, Jingzhong; Liu, Yongmei] Wake Forest Univ, Bowman Gray Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
   [Herrington, David M.] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Cardiol Sect, Winston Salem, NC 27157 USA.
   [Kritchevsky, Stephen B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC 27157 USA.
   [Launer, Leonore J.; Harris, Tamara B.] NIA, Lab Epidemiol Demog Biometry, NIH, Bethesda, MD 20892 USA.
   [Barratt, Bryan J.] AstraZeneca, Personalised Healthcare & Biomarkers, Macclesfield SK10 4TG, Cheshire, England.
   [Nyberg, Fredrik] AstraZeneca Res & Dev, S-48183 Molndal, Sweden.
   [Nyberg, Fredrik] Univ Gothenburg, Unit Occupat & Environm Med, S-40530 Gothenburg, Sweden.
   [Stricker, Bruno H.; Uitterlinden, Andre G.; Rivadeneira, Fernando] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands.
   [Denny, Joshua C.] Vanderbilt Univ, Dept Med, Vanderbilt, TN 37240 USA.
   [Ballantyne, Christie M.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   [Psaty, Bruce M.] Univ Washington, Dept Hlth Serv, Seattle, WA 98101 USA.
   [Colhoun, Helen M.] Univ Dundee, Dept Publ Hlth, Dundee DD1 9SY, Scotland.
   [Hitman, Graham] Queen Mary Univ, Barts & London Sch Med & Dent, London E1 2A1, England.
   [Krauss, Ronald M.] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA.
   [Jukema, J. Wouter] Durrer Ctr Cardiogenet Res, NL-1105 AZ Amsterdam, Netherlands.
   [Jukema, J. Wouter] Interuniv Cardiol Inst Netherlands, NL-3511 GC Utrecht, Netherlands.
RP Jukema, JW (reprint author), Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands.
EM j.w.jukema@lumc.nl; m.j.caulfield@qmul.ac.uk
RI Palmer, Colin/C-7053-2008; Slagboom, P. Eline/R-4790-2016; Dube,
   Marie-Pierre/B-9364-2008; Blackwell, Jenefer/H-3015-2015; Jankowski,
   Janusz/H-2706-2012; Gudnason, Vilmundur/K-6885-2015; Deloukas,
   Panos/B-2922-2013; Rivadeneira, Fernando/O-5385-2015; Smith,
   Albert/K-5150-2015; Study, GoDARTS/K-9448-2016; Johnson,
   Andrew/G-6520-2013; Boekholdt, Matthijs/G-7562-2014; 
OI Palmer, Colin/0000-0002-6415-6560; Slagboom, P.
   Eline/0000-0002-2875-4723; Dube, Marie-Pierre/0000-0001-8442-4393;
   Jankowski, Janusz/0000-0003-2130-9181; Gudnason,
   Vilmundur/0000-0001-5696-0084; Deloukas, Panos/0000-0001-9251-070X;
   Rivadeneira, Fernando/0000-0001-9435-9441; Smith,
   Albert/0000-0003-1942-5845; Corvin, Aiden/0000-0001-6717-4089; Stanton,
   Alice/0000-0002-4961-165X; Ramachandran, Vasan/0000-0001-7357-5970;
   Gillman, Matthew/0000-0002-2340-6930; Plomin,
   Robert/0000-0002-0756-3629; Colhoun, Helen/0000-0002-8345-3288; Wood,
   Nicholas/0000-0002-9500-3348; Pirinen, Matti/0000-0002-1664-1350
FU Bristol-Myers Squibb, USA; European Union [HEALTH-F2-2009-223004];
   Netherlands Consortium for Healthy Ageing (NGI) [05060810]; Pfizer, USA;
   National Institutes for Health Research (NIHR) as part of the portfolio
   of translational research of the NIHR Biomedical Research Unit at Barts;
   NIHR Biomedical Research Centre at Imperial College; International
   Centre for Circulatory Health Charity; Medical Research Council
   [G952010]; Pfizer, Diabetes UK; Department of Health; National
   Institutes of Health from the National Heart, Lung, and Blood Institute
   [U19 HL069757]; National Center for Advancing Translational Sciences
   [UL1TR000124, 2 UL1 TR000445]; Pfizer; NIH [N01-AG-1-2100]; NIA
   Intramural Research Program, Hjartavernd (the Icelandic Heart
   Association); Althingi (the Icelandic Parliament); National Heart, Lung,
   and Blood Institute contracts [HHSN268201100005C, HHSN268201100006C,
   HHSN268201100007C, HHSN268201100008C, HHSN268201100009C,
   HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, R01HL087641,
   R01HL59367, R01HL086694]; National Human Genome Research Institute
   contract [U01HG004402]; National Institutes of Health contract
   [HHSN268200625226C]; National Institutes of Health and NIH Roadmap for
   Medical Research [UL1RR025005]; National Center for Research Resources
   [UL1 RR024975]; National Human Genome Research Institute [U01-HG04603];
   National Insitute of General Medical Sciences [RC2-GM092318]; NHLBI
   [HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079,
   N01HC85080, N01HC85081, N01HC85082, N01HC85083, HL080295, N01HC85086,
   HL087652, HL105756, HL103612, HL085251, HL073410, HL068986]; National
   Institute of Neurological Disorders and Stroke (NINDS); National
   Institute on Aging (NIA) [AG023629]; National Center for Advancing
   Translational Sciences; CTSI grant [UL1TR000124]; National Institute of
   Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC)
   grant [DK063491]; National Heart Lung and Blood Institute of the
   National Institutes of Health; Boston University School of Medicine
   [N01-HC-25195]; Affymetrix, Inc. [N02-HL-6-4278]; Robert Dawson Evans
   Endowment of the Department of Medicine at Boston University School of
   Medicine; Boston Medical Center [R01HL103612]; Wellcome Trust United
   Kingdom Type 2 Diabetes Case Control Collection (GoDARTS); Scottish
   Health Informatics Programme; Wellcome Trust Case Control Consortium;
   Diabetes UK [07/0003525]; Wellcome Trust [084727/Z/08/Z, 085475/Z/08/Z,
   085475/B/08/Z]; EU IMI-SUMMIT programme; NIA [N01AG62101, N01AG62103,
   N01AG62106, 1R01AG032098-01A1]; National Institutes of Health
   [HHSN268200782096C]; Intramural Research Program of the NIH, National
   Institute on Aging; National Heart, Lung, and Blood Institute (NHLBI);
   MESA investigators; Clinical Translational Science Institute grant
   [UL1RR033176]; AstraZeneca; Erasmus Medical Center; Erasmus University
   Rotterdam; Netherlands Organization for Health Research and Development
   (ZonMw); Research Institute for Diseases in the Elderly; Ministry of
   Education, Culture and Science; Ministry of Health Welfare and Sports;
   European Commission; Municipality of Rotterdam; Netherlands Genomics
   Initiative (NGI) Netherlands Organization for Scietific Research (NOW)
   [050-060-810];  [N01 HC-95159];  [N01-HC-95169];  [RR024156]
FX PROSPER/PHASE: The Prospective Study of Pravastatin in the Elderly at
   Risk (PROSPER) trial was supported by an investigator-initiated grant
   from Bristol-Myers Squibb, USA. The study was conducted, analysed and
   reported independently of the company. The GWAS project PHASE has
   received funding from the European Union's Seventh Framework Programme
   (FP7/2007-2013) under grant agreement HEALTH-F2-2009- 223004. A part of
   the genotyping was funded by The Netherlands Consortium for Healthy
   Ageing (NGI: 05060810). Professor Dr J.W.J. is an established clinical
   investigator of The Netherlands Heart Foundation (2001 D 032).; ASCOT:
   The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) trial was funded
   by an investigator-initiated grant from Pfizer, USA. The study was
   investigator led and was conducted, analysed and reported independently
   of the company. The Genomewide Association Scan was funded by the
   National Institutes for Health Research (NIHR) as part of the portfolio
   of translational research of the NIHR Biomedical Research Unit at Barts
   and the NIHR Biomedical Research Centre at Imperial College, the
   International Centre for Circulatory Health Charity and the Medical
   Research Council through G952010. On behalf of the ASCOT investigators,
   we thank all ASCOT trial participants, physicians, nurses, and practices
   in the participating countries for their important contribution to the
   study.; CARDS: We thank the other investigators, the staff and the
   participants of the CARDS study. A full list of CARDS investigators can
   be found in original CARDS paper<SUP>71</SUP>. CARDS was funded by
   grants to the Universities of London and Manchester by Pfizer, Diabetes
   UK and the Department of Health.; PARC: This research was supported by
   the National Institutes of Health: grant U19 HL069757 from the National
   Heart, Lung, and Blood Institute, and grant UL1TR000124 from the
   National Center for Advancing Translational Sciences.; TNT: The TNT
   study was funded by Pfizer, who also provided support for genotyping.;
   AGES: This study has been funded by NIH contract N01-AG-1-2100, the NIA
   Intramural Research Program, Hjartavernd (the Icelandic Heart
   Association) and the Althingi (the Icelandic Parliament). The study is
   approved by the Icelandic National Bioethics Committee, VSN: 00-063. The
   researchers are indebted to the participants for their willingness to
   participate in the study.; ARIC: The Atherosclerosis Risk in Communities
   Study is carried out as a collaborative study supported by National
   Heart, Lung, and Blood Institute contracts (HHSN268201100005C,
   HHSN268201100006C, HHSN268201100007C, HHSN268201100008C,
   HHSN268201100009C, HHSN268201100010C, HHSN268201100011C and
   HHSN268201100012C), R01HL087641, R01HL59367 and R01HL086694; National
   Human Genome Research Institute contract U01HG004402; and National
   Institutes of Health contract HHSN268200625226C. We thank the staff and
   participants of the ARIC study for their important contributions.
   Infrastructure was partly supported by Grant Number UL1RR025005, a
   component of the National Institutes of Health and NIH Roadmap for
   Medical Research.; BioVU: BioVU receives support through the National
   Center for Research Resources UL1 RR024975, which is now the National
   Center for Advancing Translational Sciences, 2 UL1 TR000445. Genotyping
   was supported via grant U01-HG04603 from the National Human Genome
   Research Institute and RC2-GM092318 from the National Insitute of
   General Medical Sciences.; CHS: This CHS research was supported by NHLBI
   contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079,
   N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086; and NHLBI
   grants HL080295, HL087652, HL105756 and HL103612 with additional
   contribution from the National Institute of Neurological Disorders and
   Stroke (NINDS). Additional support was provided through AG023629 from
   the National Institute on Aging (NIA). A full list of CHS investigators
   and institutions can be found at http://www.chs-nhlbi.org/pi.htm. The
   provision of genotyping data was supported in part by the National
   Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and
   the National Institute of Diabetes and Digestive and Kidney Disease
   Diabetes Research Center (DRC) grant DK063491 to the Southern California
   Diabetes Endocrinology Research Center.; Framingham HS: The Framingham
   Heart Study work was supported by the National Heart Lung and Blood
   Institute of the National Institutes of Health and Boston University
   School of Medicine (Contract No. N01-HC-25195), its contract with
   Affymetrix, Inc. for genotyping services (Contract No. N02-HL-6-4278)
   and based on analyses by Framingham Heart Study investigators
   participating in the SNP Health Association Resource (SHARe) project. A
   portion of this research was conducted using the Linux Cluster for
   Genetic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment
   of the Department of Medicine at Boston University School of Medicine
   and Boston Medical Center, also supported by R01HL103612 (PI psaty,
   subcontract PI, Vasan).; GoDARTS: We are grateful to all the
   participants who took part in this study, to the general practitioners,
   to the Scottish School of Primary Care for their help in recruiting the
   participants and to the whole team, which includes interviewers,
   computer and laboratory technicians, clerical workers, research
   scientists, volunteers, managers, receptionists and nurses. The Wellcome
   Trust provides support for Wellcome Trust United Kingdom Type 2 Diabetes
   Case Control Collection (GoDARTS) and informatics support is provided by
   the Chief Scientist Office. The Wellcome Trust funds the Scottish Health
   Informatics Programme, provides core support for the Wellcome Trust
   Centre for Human Genetics in Oxford and funds the Wellcome Trust Case
   Control Consortium. This research was specifically funded by Diabetes UK
   (07/0003525) and the Wellcome Trust (084727/Z/08/Z, 085475/Z/08/Z and
   085475/B/08/Z). Genotyping of the GoDARTS samples (sample 2) was also
   funded as part of the EU IMI-SUMMIT programme. K.Z. holds a Henry
   Wellcome Post-Doctoral Fellowship.; Health ABC: The Health ABC study was
   supported by NIA contracts N01AG62101, N01AG62103 and N01AG62106. The
   genome-wide association study was funded by NIA grant 1R01AG032098-01A1
   to Wake Forest University Health Sciences and genotyping services were
   provided by the Center for Inherited Disease Research (CIDR). CIDR is
   fully funded through a federal contract from the National Institutes of
   Health to The Johns Hopkins University, contract number
   HHSN268200782096C. This research was supported in part by the Intramural
   Research Program of the NIH, National Institute on Aging.; HVH: This
   Heart and Vascular Health Study research was supported by NHLBI grants
   HL085251, HL073410, HL085251 and HL068986.; MESA: The Multi-Ethnic Study
   of Atherosclerosis (MESA) and MESA SNP Health Association Resource
   (SHARe) are conducted and supported by the National Heart, Lung, and
   Blood Institute (NHLBI) in collaboration with MESA investigators.
   Support is provided by grants and contracts N01 HC-95159 through
   N01-HC-95169 and RR024156. Additional funding was supported in part by
   the Clinical Translational Science Institute grant UL1RR033176 and is
   now at the National Center for Advancing Translational Sciences, CTSI
   grant UL1TR000124. We thank the other investigators in the
   Pharmarcogenetics Working Group, the staff and the participants of the
   MESA study for their valuable contributions. A full list of
   participating MESA investigators and institutions can be found at
   http://www.mesa-nhlbi.org.; JUPITER: Genetic analysis in JUPITER was
   supported by a research grant from AstraZeneca to D. C. and P. M.;
   Rotterdam study: The Rotterdam Study is supported by the Erasmus Medical
   Center and Erasmus University Rotterdam; the Netherlands Organization
   for Health Research and Development (ZonMw); the Research Institute for
   Diseases in the Elderly; the Ministry of Education, Culture and Science;
   the Ministry of Health Welfare and Sports; and the European Commission
   and Municipality of Rotterdam. This work was supported by the
   Netherlands Genomics Initiative (NGI) Netherlands Organization for
   Scietific Research (NOW; 050-060-810).
NR 71
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U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5068
DI 10.1038/ncomms6068
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS0OK
UT WOS:000343977100003
PM 25350695
ER

PT J
AU Seo, M
   Lee, S
   Kim, JH
   Lee, WH
   Hu, G
   Elledge, SJ
   Suk, K
AF Seo, Minchul
   Lee, Shinrye
   Kim, Jong-Heon
   Lee, Won-Ha
   Hu, Guang
   Elledge, Stephen J.
   Suk, Kyoungho
TI RNAi-based functional selection identifies novel cell migration
   determinants dependent on PI3K and AKT pathways
SO NATURE COMMUNICATIONS
LA English
DT Article
ID POTENTIAL THERAPEUTIC TARGET; PUTATIVE TUMOR-SUPPRESSOR; PROTEIN-KINASE
   CK2; CANCER CELL; REGULATORY SUBUNIT; CYCLE PROGRESSION; OVARIAN-CANCER;
   BREAST-CANCER; HUMAN-DISEASE; KAPPA-B
AB Lentiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying loss-of-function phenotype in mammalian cells. Here, we report the identification of 91 cell migration-regulating genes using unbiased genome-wide functional genetic selection. Individual knockdown or cDNA overexpression of a set of 10 candidates reveals that most of these cell migration determinants are strongly dependent on the PI3K/PTEN/AKT pathway and on their downstream signals, such as FOXO1 and p70S6K1. ALK, one of the cell migration promoting genes, uniquely uses p55 gamma regulatory subunit of PI3K, rather than more common p85 subunit, to trigger the activation of the PI3K-AKT pathway. Our method enables the rapid and cost-effective genome-wide selection of cell migration regulators. Our results emphasize the importance of the PI3K/PTEN/AKT pathway as a point of convergence for multiple regulators of cell migration.
C1 [Seo, Minchul; Lee, Shinrye; Kim, Jong-Heon; Suk, Kyoungho] Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Dept Pharmacol,Brain Sci & Engn Inst, Taegu, South Korea.
   [Seo, Minchul] Dongguk Univ, Coll Med, Gyeongju, South Korea.
   [Lee, Shinrye] Korea Brain Res Inst, Taegu, South Korea.
   [Lee, Won-Ha] Kyungpook Natl Univ, Sch Life Sci & Biotechnol, KNU Creat BioRes Grp, Taegu, South Korea.
   [Hu, Guang] Natl Inst Environm Hlth & Sci, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA.
   [Elledge, Stephen J.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Genet,Howard Hughes Med Inst,Div Genet, Boston, MA 02115 USA.
RP Suk, K (reprint author), Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Dept Pharmacol,Brain Sci & Engn Inst, Taegu, South Korea.
EM ksuk@knu.ac.kr
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
   [2008-0062282, 2012M3A9B6055414]; Korean Health technology R&D Project,
   Ministry of Health & Welfare, Republic of Korea [A111345]; DOD Breast
   Cancer Innovator Award; SU2C at Howard Hughes Medical Institute
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP) (Nos 2008-0062282 and
   2012M3A9B6055414) and by a grant from the Korean Health technology R&D
   Project, Ministry of Health & Welfare, Republic of Korea (A111345). This
   work was also supported by a DOD Breast Cancer Innovator Award and a
   grant from SU2C to S.J.E. at the Howard Hughes Medical Institute. The
   authors thank Dr Young-il Park at Young-il Sciences Inc. (Daegu, Korea)
   for generously providing Incucyte and Woundmaker (Essen BioScience, Ann
   Arbor, MI).
NR 70
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Z9 6
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5217
DI 10.1038/ncomms6217
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS0QO
UT WOS:000343982800006
PM 25347953
ER

PT J
AU Shen, HH
   Leyton, DL
   Shiota, T
   Belousoff, MJ
   Noinaj, N
   Lu, JX
   Holt, SA
   Tan, K
   Selkrig, J
   Webb, CT
   Buchanan, SK
   Martin, LL
   Lithgow, T
AF Shen, Hsin-Hui
   Leyton, Denisse L.
   Shiota, Takuya
   Belousoff, Matthew J.
   Noinaj, Nicholas
   Lu, Jingxiong
   Holt, Stephen A.
   Tan, Khershing
   Selkrig, Joel
   Webb, Chaille T.
   Buchanan, Susan K.
   Martin, Lisandra L.
   Lithgow, Trevor
TI Reconstitution of a nanomachine driving the assembly of proteins into
   bacterial outer membranes
SO NATURE COMMUNICATIONS
LA English
DT Article
ID PERIPLASMIC CHAPERONE SKP; ESCHERICHIA-COLI; AUTOTRANSPORTER PROTEINS;
   COMPLEX; BIOGENESIS; SECRETION; IDENTIFICATION; INTERFACES; MACHINERY
AB In biological membranes, various protein secretion devices function as nanomachines, and measuring the internal movements of their component parts is a major technological challenge. The translocation and assembly module (TAM) is a nanomachine required for virulence of bacterial pathogens. We have reconstituted a membrane containing the TAM onto a gold surface for characterization by quartz crystal microbalance with dissipation (QCM-D) and magnetic contrast neutron reflectrometry (MCNR). The MCNR studies provided structural resolution down to 1 angstrom, enabling accurate measurement of protein domains projecting from the membrane layer. Here we show that dynamic movements within the TamA component of the TAM are initiated in the presence of a substrate protein, Ag43, and that these movements recapitulate an initial stage in membrane protein assembly. The reconstituted system provides a powerful new means to study molecular movements in biological membranes, and the technology is widely applicable to studying the dynamics of diverse cellular nanomachines.
C1 [Shen, Hsin-Hui; Leyton, Denisse L.; Shiota, Takuya; Belousoff, Matthew J.; Tan, Khershing; Selkrig, Joel; Webb, Chaille T.; Lithgow, Trevor] Monash Univ, Dept Microbiol, Melbourne, Vic 3800, Australia.
   [Shen, Hsin-Hui; Martin, Lisandra L.] Monash Univ, Sch Chem, Melbourne, Vic 3800, Australia.
   [Shen, Hsin-Hui; Lu, Jingxiong] Monash Univ, Dept Chem Engn, Melbourne, Vic 3800, Australia.
   [Noinaj, Nicholas; Buchanan, Susan K.] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Holt, Stephen A.] ANSTO, Bragg Inst, Sydney, NSW 2234, Australia.
RP Lithgow, T (reprint author), Monash Univ, Dept Microbiol, Melbourne, Vic 3800, Australia.
EM trevor.lithgow@monash.edu
RI Leyton, Denisse/A-6915-2015; Holt, Stephen/E-4662-2011; McKenzie,
   Warren/J-2137-2014; Martin, Lisandra/E-4482-2010
FU ISIS (Science and Technologies Facility Council, UK); Australian
   Research Council (ARC) through the Super Science Fellowship Grant
   [FS110200015]; NHMRC Program Grant [606788]; Intramural Research Program
   of the NIH, National Institute of Diabetes and Digestive and Kidney
   Diseases
FX We thank Michelle Gee and Ana Traven for constructive comments on the
   manuscript. We gratefully acknowledge support by ISIS (Science and
   Technologies Facility Council, UK) in providing neutron research
   facilities for this project, and the Australian Research Council (ARC)
   for research funding through the Super Science Fellowship grant
   FS110200015 (to T. L. and L. M.) and NHMRC Program Grant 606788 (to T.
   L.). This work was performed in part at the Melbourne Centre for
   Nanofabrication (MCN) in the Victorian Node of the Australian National
   Fabrication Facility (ANFF). N.N. and S. K. B. are supported by the
   Intramural Research Program of the NIH, National Institute of Diabetes
   and Digestive and Kidney Diseases. H.-H.S. and D. L. L. are ARC Super
   Science Fellows and T. L. is an ARC Australian Laureate Fellow.
NR 45
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U1 5
U2 41
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5078
DI 10.1038/ncomms6078
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS0OR
UT WOS:000343977900002
PM 25341963
ER

PT J
AU Zhao, C
   Hoppe, T
   Setty, MKHG
   Murray, D
   Chun, TW
   Hewlett, I
   Appella, DH
AF Zhao, Chao
   Hoppe, Travis
   Setty, Mohan Kumar Haleyur Giri
   Murray, Danielle
   Chun, Tae-Wook
   Hewlett, Indira
   Appella, Daniel H.
TI Quantification of plasma HIV RNA using chemically engineered peptide
   nucleic acids
SO NATURE COMMUNICATIONS
LA English
DT Article
ID RESOURCE-LIMITED SETTINGS; SANDWICH-HYBRIDIZATION; DNA DETECTION; POINT;
   ASSAY; CARE; NANOPARTICLES; ACCURACY; COMPLEX; BLOOD
AB The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection of HIV RNA at clinically relevant levels that are competitive with current PCR-based assays. Using a sandwich hybridization approach, chemical groups were systematically introduced into a surface PNA probe and a reporter PNA probe to achieve quantitative detection for HIV RNA as low as 20 copies per millilitre of plasma. For the surface PNA probe, four cyclopentane groups were incorporated to promote stronger binding to the target HIV RNA compared with PNA without the cyclopentanes. For the reporter PNA probe, 25 biotin groups were attached to promote strong signal amplification after binding to the target HIV RNA. These general approaches to engineer PNA probes may be used to detect other RNA target sequences.
C1 [Zhao, Chao; Appella, Daniel H.] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA.
   [Hoppe, Travis] NIDDK, Lab Biochem & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
   [Setty, Mohan Kumar Haleyur Giri; Hewlett, Indira] FDA, Mol Virol Lab, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
   [Murray, Danielle; Chun, Tae-Wook] NIDDK, Immunoregulat Lab, NIH, DHHS, Bethesda, MD 20892 USA.
RP Appella, DH (reprint author), NIDDK, Bioorgan Chem Lab, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM appellad@niddk.nih.gov
OI Hoppe, Travis/0000-0002-4694-3050
FU Intramural AIDS Targeted Antiviral Programme of NIH; Intramural Research
   Programme of NIDDK, NIH
FX This research was supported by the Intramural Research Programme of
   NIDDK, NIH and the Intramural AIDS Targeted Antiviral Programme of NIH.
   We would like to thank Dr Frank Maldarelli for assistance in processing
   the patient samples.
NR 44
TC 2
Z9 2
U1 3
U2 26
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5079
DI 10.1038/ncomms6079
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS0OR
UT WOS:000343977900003
PM 25283173
ER

PT J
AU Rudenko, I
   Cookson, M
AF Rudenko, Iakov N.
   Cookson, Mark R.
TI Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics,
   Mechanisms and Therapeutic Implications
SO NEUROTHERAPEUTICS
LA English
DT Review
DE Parkinson's disease; kinase inhibitors; GTPase; vesicular trafficking;
   cytoskeleton; treatment
ID FAMILIAL PARKINSONS-DISEASE; GTPASE-ACTIVATING PROTEIN; PATHOLOGICAL
   HUMAN BRAIN; LRRK2 G2019S; RISK-FACTOR; CAENORHABDITIS-ELEGANS;
   DOPAMINERGIC-NEURONS; TRANSGENIC MOUSE; MAINLAND CHINA; ROC DOMAIN
AB Variation within and around the leucine-rich repeat kinase 2 (LRRK2) gene is associated with familial and sporadic Parkinson's disease (PD). Here, we discuss the prevalence of LRRK2 substitutions in different populations and their association with PD, as well as molecular and cellular mechanisms of pathologically relevant LRRK2 mutations. Kinase activation was proposed as a universal molecular mechanism for all pathogenic LRRK2 mutations, but later reports revealed heterogeneity in the effect of mutations on different activities of LRRK2. One mutation (G2019S) increases kinase activity, whereas mutations in the Ras of complex proteins (ROC)-C-terminus of ROC (COR) bidomain impair the GTPase function of LRRK2. Some risk factor variants, including G2385R in the WD40 domain, actually decrease the kinase activity of LRRK2. We suggest a model where LRRK2 mutations exert different molecular mechanisms but interfere with normal cellular function of LRRK2 at different levels of the same downstream pathway. Finally, we discuss the current state of therapeutic approaches for LRRK2-related PD.
C1 [Rudenko, Iakov N.; Cookson, Mark R.] NIA, Cell Biol & Gene Express Sect, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.
RP Cookson, M (reprint author), NIA, Cell Biol & Gene Express Sect, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.
EM cookson@mail.nih.gov
FU Intramural Research Program of the National Institute on Aging, National
   Institutes of Health
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging, National Institutes of Health.
NR 175
TC 9
Z9 9
U1 2
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1933-7213
EI 1878-7479
J9 NEUROTHERAPEUTICS
JI Neurotherapeutics
PD OCT
PY 2014
VL 11
IS 4
BP 738
EP 750
DI 10.1007/s13311-014-0284-z
PG 13
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AS3AI
UT WOS:000344147100006
PM 24957201
ER

PT J
AU Schisterman, EF
   Silver, RM
   Lesher, LL
   Faraggi, D
   Wactawski-Wende, J
   Townsend, JM
   Lynch, AM
   Perkins, NJ
   Mumford, SL
   Galai, N
AF Schisterman, Enrique F.
   Silver, Robert M.
   Lesher, Laurie L.
   Faraggi, David
   Wactawski-Wende, Jean
   Townsend, Janet M.
   Lynch, Anne M.
   Perkins, Neil J.
   Mumford, Sunni L.
   Galai, Noya
TI Preconception Low-Dose Aspirin and Pregnancy Outcomes: Results From the
   EAGeR Randomized Trial EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB Pregnancy loss occurs in up to 30% of conceptions. Women who have had a pregnancy loss are at increased risk for having another loss or adverse pregnancy event. Because aspirin can improve blood flow and reduce inflammation in the reproductive organs, preconception-initiated low-dose aspirin might positively affect pregnancy outcomes. The aim of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was to assess whether daily treatment with low-dose aspirin, initiated before conception, would improve the rate of live birth in women who had 1 or 2 prior pregnancy losses. The initial stratum in the EAGeR trial included women aged 18 to 40 years who were actively trying to conceive and who had had 1 pregnancy loss at less than 20 weeks' gestation. Because of slow recruitment, criteria were expanded to women with 1 or 2 prior losses and no restriction on gestational age or time of loss. The women received daily low-dose aspirin (81 mg) plus 400 g of folic acid or placebo plus 400 g of folic acid. Study tablets were taken daily until completion of 6 menstrual cycles while attempting conception or until 36 weeks' gestation if pregnancy occurred. The primary outcome was live birth. Secondary outcomes were implantation, confirmed pregnancy, pregnancy loss, birth weight, and serious obstetrical complications. Between 2007 and 2011, of 1228 women recruited, 1078 completed the study, 535 and 543 in the aspirin and placebo groups, respectively. The treatment groups were similar in demographic and baseline characteristics. The treatment groups did not differ significantly in live birth rates; 309 (58%) of the women in the aspirin group had live births compared with 286 (53%) in the placebo group (P = 0.984; absolute difference in live birth rate, 5.09%; 95% confidence interval [CI], -0.84 to 11.02). In the original stratum, 151 (62%) of 242 women in the aspirin group had live births compared with 133 (53%) of 250 women in the placebo group (P = 0.0446; absolute difference, 9.20%; 95% CI, 0.51 to -17.89). In the expanded stratum, 158 (54%) of 293 women in the aspirin group and 153 (52%) of 293 women in the placebo group had live births (P = 0.7406; absolute difference, 1.71%; 95% CI, -6.37 to 9.79). The treatment groups did not differ significantly with regard to pregnancy complications that occurred after implantation, including pregnancy loss. No major birth defects were reported, and no difference was seen in the proportion of minor birth defects between the groups. Vaginal bleeding was more common in the women who received low-dose aspirin (n = 24) than in those given placebo (n = 8; P = 0.0038) but was not associated with pregnancy loss. Self-reported adherence to treatment assignment was similar between the groups. Preconception-initiated treatment with low-dose aspirin was not significantly associated with live birth rates, pregnancy loss, or other pregnancy complications. Because of the low cost, availability, and apparent safety of low-dose aspirin, further investigation is warranted into its effects on fecundity and implantation.
C1 [Schisterman, Enrique F.; Perkins, Neil J.; Mumford, Sunni L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, Bethesda, MD 20892 USA.
   [Silver, Robert M.; Lesher, Laurie L.] Univ Utah, Sch Med, Dept Obstet & Gynecol, Hlth Sci Ctr, Salt Lake City, UT 84132 USA.
   [Faraggi, David; Galai, Noya] Univ Haifa, Dept Stat, IL-31999 Haifa, Israel.
   [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
   [Townsend, Janet M.] Commonwealth Med Coll, Dept Family Community & Rural Hlth, Scranton, PA USA.
   [Lynch, Anne M.] Univ Colorado, Dept Obstet & Gynecol, Denver, CO 80202 USA.
RP Schisterman, EF (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, Bethesda, MD 20892 USA.
NR 4
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD OCT
PY 2014
VL 69
IS 10
BP 571
EP 573
DI 10.1097/OGX.0000000000000116
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AS7RS
UT WOS:000344453200002
ER

PT J
AU Skuladottir, H
   Wilcox, AJ
   Ma, C
   Lammer, EJ
   Rasmussen, SA
   Werler, MM
   Shaw, GM
   Carmichael, SL
AF Skuladottir, Hildur
   Wilcox, Allen J.
   Ma, Chen
   Lammer, Edward J.
   Rasmussen, Sonja A.
   Werler, Martha M.
   Shaw, Gary M.
   Carmichael, Suzan L.
TI Corticosteroid Use and Risk for Orofacial Clefts EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB Orofacial clefts are one of the most common birth defects, with a worldwide prevalence of 1.7 per 1000 live births. Epidemiologic studies have reported inconsistent results regarding an association between corticosteroid use in early pregnancy and delivering an infant with an orofacial cleft. Although corticosteroids are used in women of reproductive age for many common conditions, the safety of these medications during pregnancy is uncertain. The authors previously reported that maternal corticosteroid use was associated with an increased risk for cleft lip with or without palate (CLP) but not cleft palate only (CPO) in deliveries in 1997 to 2002. Since that report, the pertinent population has more than doubled, allowing the largest study of corticosteroids and clefts to date. The aim of the present study was to assess the association using larger and more recent data from the National Birth Defects Prevention Study (NBDPS). Information on deliveries in 1997 to 2009 was collected from 10 centers. Infants or fetuses with CLP or CPO were considered cases and analyzed separately. Cases were considered isolated if there were no accompanying major unrelated birth defects or as nonisolated if more than 1 additional major unrelated defect was present. Live-born control infants without birth defects were randomly selected from birth records. Mothers were interviewed by telephone 6 weeks to 24 months after delivery. The mothers were asked whether they had specific medical conditions before or during pregnancy and what medications were used to treat them. The focus was on periconceptional corticosteroid use by any administration route and component that occurred between 4 weeks before and 12 weeks after conception. Outcomes were an association with specific timing of exposure, mode of administration, or corticosteroid component. Logistic regression models were used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs). Adjustments were made for covariates, including maternal race/ethnicity, education, intake of folic acid, smoking, and study center. Results were presented for deliveries from January 2003 through December 2009 and for pooled data for deliveries from October 1997 through December 2009. From 2003 to 2009, the NBDPS enrolled mothers of 1577 children with CLP, 795 children with CPO, and 5922 control children. A total of 1402 (89%) of the CLP cases and 631 (79%) of the CPO cases were isolated. Any use of corticosteroids 4 weeks before through 12 weeks after conception was reported by mothers of 35 infants (2.3%) with CLP (OR, 1.0; 95% CI, 0.7-1.4), mothers of 13 infants (1.7%) with CPO (OR, 0.7; 95% CI, 0.4-1.2), and mothers of 137 control infants (2.4%). No association was found with route of administration or components of corticosteroids. When earlier and recent data were combined, the cohort included mothers of 2731 infants with CLP, 1429 infants with CPO, and 10,063 controls, delivered in 1997 to 2009. Mothers of 69 infants (2.6%) with CLP (OR, 1.2; 95% CI, 0.9-1.6), 19 infants (1.3%) with CPO (OR, 0.6; 95% CI, 0.4-1.0), and 214 controls (2.1%) reported using any corticosteroids during the specified period. No association was found for route of administration or component of corticosteroid in the combined data, except for prednisone (OR, 1.9; 95% CI, 1.0-3.7). For CLP, ORs ranged from 2.8 (95% CI, 1.3-5.9) for exposures only during weeks 1 to 4 and 5 to 8 after conception to 0.5 (95% CI, 0.1-1.6) for exposures during weeks 9 to 12.
   Recent data from the NBDPS did not support an association between maternal corticosteroid use during early pregnancy and delivering an infant with an orofacial cleft. These data may help patients and clinicians in making their risk-benefit decisions for using corticosteroids during the first trimester.
C1 [Skuladottir, Hildur] Haukeland Hosp, Dept Plast Surg, Bergen, Norway.
   [Skuladottir, Hildur] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
   [Wilcox, Allen J.] NIEHS, NIH, Durham, NC USA.
   [Ma, Chen; Shaw, Gary M.; Carmichael, Suzan L.] Stanford Univ, Dept Pediat, Div Neonatol & Dev Med, Sch Med, Stanford, CA 94305 USA.
   [Lammer, Edward J.] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA.
   [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
   [Werler, Martha M.] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
RP Skuladottir, H (reprint author), Haukeland Hosp, Dept Plast Surg, Bergen, Norway.
NR 4
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD OCT
PY 2014
VL 69
IS 10
BP 573
EP 575
DI 10.1097/01.ogx.0000456345.09228.f3
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AS7RS
UT WOS:000344453200003
ER

PT J
AU Schisterman, EF
   Silver, RM
   Lesher, LL
   Faraggi, D
   Wactawski-Wende, J
   Townsend, JM
   Lynch, AM
   Perkins, NJ
   Mumford, SL
   Galai, N
AF Schisterman, Enrique F.
   Silver, Robert M.
   Lesher, Laurie L.
   Faraggi, David
   Wactawski-Wende, Jean
   Townsend, Janet M.
   Lynch, Anne M.
   Perkins, Neil J.
   Mumford, Sunni L.
   Galai, Noya
TI Preconception Low-Dose Aspirin and Pregnancy Outcomes: Results From the
   EAGeR Randomised Trial EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB Women with a history of pregnancy loss are at increased risk of a subsequent loss and other adverse pregnancy outcomes. The pathophysiologic mechanisms responsible for pregnancy loss are unclear. It is believed that decreased blood flow and increased inflammation may play an important role in pregnancy loss and other adverse pregnancy events. Because aspirin can improve blood flow and reduce inflammation in reproductive organs, it has been hypothesized that giving aspirin to women attempting to conceive might improve pregnancy outcomes. Many health care providers prescribe low-dose preconception aspirin therapy for women who have had a pregnancy loss and who would like to get pregnant again. However, the efficacy of this treatment is unproven. The aim of the EAGeR (Effects of Aspirin in Gestation and Reproduction) trial was to determine whether preconception treatment with low-dose aspirin would reduce the risk of pregnancy loss in women with 1 or 2 previous pregnancy losses. The study was a multicenter, block-randomized, double-blind, placebo-controlled trial conducted in women aged 18 to 40 years with a history of pregnancy loss who were attempting to become pregnant. Participants were recruited from 4 university medical centers in the United States. The original stratum included women who had 1 loss at less than 20 weeks' gestation during the previous year. Because of slow enrollment, the stratum was expanded to include women with 1 to 2 previous losses without any restrictions on gestational age or time of loss. Prior to conception, women were randomized to receive either low-dose aspirin (81 mg/d) plus folic acid or placebo plus folic acid for up to 6 menstrual cycles. Treatment was continued until 36 weeks' gestation for women who became pregnant. Trial staff, investigators, and participants were masked to the assigned treatment. The primary study outcome was live birth rate. Data were analyzed according to intention to treat. Of the 1228 women randomly assigned between 2007 and 2011, 1078 (88%) completed the trial and were included in the analysis (535 in the aspirin group and 543 in the placebo group). A total of 309 women (58%) in the low-dose aspirin group became pregnant and later gave birth, compared with 286 (53%) in the placebo group (absolute difference, 5.09%; 95% confidence interval [CI], -0.84% to 11.02%; P = 0.10). Pregnancy loss occurred in 68 (13%) of the women in the aspirin group and in 65 (12%) of the women in the placebo group (P = 0.78). Among women in the original stratum, who had a single recent pregnancy loss, live births occurred in 62% (151/242) of women in the aspirin group, compared with 53% (133/250) of those in the placebo group; the absolute difference was 9.2%, with a 95% CI of 0.51% to 17.89%, P = 0. 045. In the expanded stratum, however, no significant difference between treatment groups occurred in live birth rates (54% [158/293] in the low-dose aspirin group vs 52% [153/293] in the placebo group; absolute difference, 1.71%; 95% CI, -6.37% to 9.79%; P = 0.74). Major adverse events in both treatment groups were similar. Low-dose aspirin was associated with increased vaginal bleeding, but this was not associated with pregnancy loss. The use of preconception-initiated low-dose aspirin to prevent recurrent pregnancy loss is not supported by these data. Further studies are needed to investigate the apparent increased birth rate among women who had a single well-documented loss at less than 20 weeks' gestation during the previous year.
C1 [Schisterman, Enrique F.; Perkins, Neil J.; Mumford, Sunni L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, Bethesda, MD 20817 USA.
   [Silver, Robert M.; Lesher, Laurie L.] Univ Utah, Hlth Sci Ctr, Dept Obstet & Gynecol, Salt Lake City, UT USA.
   [Faraggi, David; Galai, Noya] Univ Haifa, Dept Stat, IL-31999 Haifa, Israel.
   [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
   [Townsend, Janet M.] Commonwealth Med Coll, Dept Family Community & Rural Hlth, Scranton, PA USA.
   [Lynch, Anne M.] Univ Colorado, Dept Obstet & Gynecol, Denver, CO 80202 USA.
RP Schisterman, EF (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, Bethesda, MD 20817 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD OCT
PY 2014
VL 69
IS 10
BP 592
EP 594
DI 10.1097/OGX.0000000000000108
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AS7RS
UT WOS:000344453200013
ER

PT J
AU Legro, RS
   Brzyski, RG
   Diamond, MP
   Coutifaris, C
   Schlaff, WD
   Casson, P
   Christman, GM
   Huang, H
   Yan, QS
   Alvero, R
   Haisenleder, DJ
   Barnhart, KT
   Bates, GW
   Usadi, R
   Lucidi, S
   Baker, V
   Trussell, JC
   Krawetz, SA
   Snyder, P
   Ohl, D
   Santoro, N
   Eisenberg, E
   Zhang, HP
AF Legro, Richard S.
   Brzyski, Robert G.
   Diamond, Michael P.
   Coutifaris, Christos
   Schlaff, William D.
   Casson, Peter
   Christman, Gregory M.
   Huang, Hao
   Yan, Qingshang
   Alvero, Ruben
   Haisenleder, Daniel J.
   Barnhart, Kurt T.
   Bates, G. Wright
   Usadi, Rebecca
   Lucidi, Scott
   Baker, Valerie
   Trussell, J. C.
   Krawetz, Stephen A.
   Snyder, Peter
   Ohl, Dana
   Santoro, Nanette
   Eisenberg, Esther
   Zhang, Heping
TI Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary
   Syndrome EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB The most common cause of female infertility is polycystic ovary syndrome (PCOS), which occurs in 5% to 10% of reproductive-age women. Clomiphene citrate has been used as a fertility agent for decades and is the current first-line infertility treatment in women with PCOS. However, this selective estrogen-receptor modulator has a number of drawbacks. In addition to its overall poor efficacy, clomiphene is associated with a high multiple-pregnancy rate compared with unassisted conception and an undesirable adverse effect profile, including changes in mood and hot flushes. More effective and safer treatments for infertility are needed. Several studies have shown that aromatase inhibitors, which block estrogen synthesis, increase pregnancy rates. Potential advantages of letrozole and other aromatase inhibitors over clomiphene include a more physiologic stimulation of the endometrium, lower multiple-pregnancy rates, and a better adverse effect profile with fewer vasomotor and mood symptoms. However, a concern for letrozole is its potential for fetal teratogenicity. The aim of this double-blind, multicenter, randomized trial was to determine whether letrozole is a better fertility agent than clomiphene in women with PCOS and has similar or better safety profile. Subjects were infertile women with PCOS between 18 and 40 years old who wished to become pregnant. A total of 750 women were randomized to receive letrozole or clomiphene for up to 5 treatment cycles. Patient visits determined ovulation and pregnancy and were followed by tracking of pregnancies. Modified Rotterdam criteria were used to diagnose PCOS. All participants had at least 1 patent fallopian tube, a normal uterine cavity, and a male partner with a sperm concentration of at least 14 million per milliliter. The women and their male partners agreed to have regular intercourse. No placebo was used because the 2 drugs were given similarly, with the same duration of treatment and stepwise increase in dose. The primary study outcome was live birth during the treatment period. Data were analyzed by intention to treat. Women in the letrozole group had more cumulative live births than did those in the clomiphene group (27.5% [103/374] vs 19.1% [72/376]; the rate ratio for live births was 1.44, with a 95% confidence interval of 1.10 to 1.87, P = 0.007. Although there was no difference between groups in overall congenital anomalies, 4 major congenital anomalies were found in the letrozole group versus 1 in the clomiphene group; however, the difference was not significant (P = 0.65). Letrozole was also associated with higher cumulative ovulation rates (61.7% [834 of 1352 treatment cycles] vs 48.3% [688 of 1425 treatment cycles], P < 0.001). No significant between-group differences were found in rates of pregnancy loss after conception (31.8% [49 of 154 pregnancies] in the letrozole group vs 29.1% [30 of 103 pregnancies] in the clomiphene group) or in rates of twin pregnancy (3.4% and 7.4%, respectively). There was a higher incidence of hot flushes in the clomiphene group and a higher incidence of fatigue and dizziness in the letrozole group. Rates of other adverse events in the 2 groups were similar. These data show that letrozole is a more effective fertility treatment than clomiphene in women with PCOS. Further studies with larger numbers of infants are needed to clarify the safety and teratogenic risks of letrozole.
C1 [Legro, Richard S.] Penn State Univ, Dept Obstet & Gynecol, Hershey, PA 17033 USA.
   [Brzyski, Robert G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA.
   [Diamond, Michael P.] Georgia Regents Univ, Dept Obstet & Gynecol, Augusta, GA USA.
   [Diamond, Michael P.; Krawetz, Stephen A.] Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI USA.
   [Coutifaris, Christos; Barnhart, Kurt T.; Snyder, Peter] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA.
   [Schlaff, William D.; Alvero, Ruben; Santoro, Nanette] Univ Colorado, Dept Obstet & Gynecol, Aurora, CO USA.
   [Casson, Peter] Univ Vermont, Dept Obstet & Gynecol, Burlington, VT USA.
   [Christman, Gregory M.; Ohl, Dana] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA.
   [Huang, Hao; Yan, Qingshang; Zhang, Heping] Yale Univ, Dept Biostat, Sch Publ Hlth, New Haven, CT USA.
   [Haisenleder, Daniel J.] Univ Virginia, Ctr Res Reprod, Ligand Core Lab, Charlottesville, VA USA.
   [Bates, G. Wright] Univ Alabama Birmingham, Birmingham, AL USA.
   [Usadi, Rebecca] Carolinas Med Ctr, Charlotte, NC 28203 USA.
   [Lucidi, Scott] Virginia Commonwealth Univ, Richmond, VA USA.
   [Baker, Valerie] Stanford Univ, Med Ctr, Stanford, CA 94305 USA.
   [Trussell, J. C.] SUNY Upstate Med Univ, Onondaga, NY USA.
   [Eisenberg, Esther] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Fertil & Infertil Branch, Rockville, MD USA.
RP Legro, RS (reprint author), Penn State Univ, Dept Obstet & Gynecol, Hershey, PA 17033 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD OCT
PY 2014
VL 69
IS 10
BP 599
EP 601
DI 10.1097/01.ogx.0000456355.64379.77
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AS7RS
UT WOS:000344453200017
ER

PT J
AU Dashnow, H
   Lonsdale, A
   Bourne, PE
AF Dashnow, Harriet
   Lonsdale, Andrew
   Bourne, Philip E.
TI Ten Simple Rules for Writing a PLOS Ten Simple Rules Article
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Editorial Material
C1 [Dashnow, Harriet] Murdoch Childrens Res Inst, Parkville, Vic, Australia.
   [Dashnow, Harriet] Victorian Life Sci Computat Initiat, Life Sci Computat Ctr, Carlton, Vic, Australia.
   [Dashnow, Harriet] Univ Melbourne, Parkville, Vic 3052, Australia.
   [Lonsdale, Andrew] Univ Melbourne, Sch Bot, Australian Res Council Ctr Excellence Plant Cell, Parkville, Vic 3052, Australia.
   [Bourne, Philip E.] NIH, Off Director, Bethesda, MD 20892 USA.
RP Dashnow, H (reprint author), Murdoch Childrens Res Inst, Parkville, Vic, Australia.
EM harriet.dashnow@unimelb.edu.au
OI Dashnow, Harriet/0000-0001-8433-6270
NR 0
TC 3
Z9 3
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD OCT
PY 2014
VL 10
IS 10
AR e1003858
DI 10.1371/journal.pcbi.1003858
PG 5
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA AS9FG
UT WOS:000344547900014
PM 25340653
ER

PT J
AU Ahmed, M
   Solbiati, L
   Brace, CL
   Breen, DJ
   Callstrom, MR
   Charboneau, JW
   Chen, MH
   Choi, BI
   de Baere, T
   Dodd, GD
   Dupuy, DE
   Gervais, DA
   Gianfelice, D
   Gillams, AR
   Lee, FT
   Leen, E
   Lencioni, R
   Littrup, PJ
   Livraghi, T
   Lu, DS
   McGahan, JP
   Meloni, MF
   Nikolic, B
   Pereira, PL
   Liang, P
   Rhim, H
   Rose, SC
   Salem, R
   Sofocleous, CT
   Solomon, SB
   Soulen, MC
   Tanaka, M
   Vogl, TJ
   Wood, BJ
   Goldberg, SN
AF Ahmed, Muneeb
   Solbiati, Luigi
   Brace, Christopher L.
   Breen, David J.
   Callstrom, Matthew R.
   Charboneau, J. William
   Chen, Min-Hua
   Choi, Byung Ihn
   de Baere, Thierry
   Dodd, Gerald D., III
   Dupuy, Damian E.
   Gervais, Debra A.
   Gianfelice, David
   Gillams, Alice R.
   Lee, Fred T., Jr.
   Leen, Edward
   Lencioni, Riccardo
   Littrup, Peter J.
   Livraghi, Tito
   Lu, David S.
   McGahan, John P.
   Meloni, Maria Franca
   Nikolic, Boris
   Pereira, Philippe L.
   Liang, Ping
   Rhim, Hyunchul
   Rose, Steven C.
   Salem, Riad
   Sofocleous, Constantinos T.
   Solomon, Stephen B.
   Soulen, Michael C.
   Tanaka, Masatoshi
   Vogl, Thomas J.
   Wood, Bradford J.
   Goldberg, S. Nahum
CA Int Working Grp Image-Guided Tumor
   Interventional Oncology Sans Front
   Soc Interventional Radiology
   Cardiovasc Interventional Radiolog
TI Image-guided Tumor Ablation: Standardization of Terminology and
   Reporting Criteria-A 10-Year Update
SO RADIOLOGY
LA English
DT Article
ID PERCUTANEOUS RADIOFREQUENCY ABLATION; RENAL-CELL CARCINOMA; VIVO PORCINE
   LIVER; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; IRREVERSIBLE
   ELECTROPORATION ABLATION; CONTRAST-ENHANCED ULTRASOUND; INTERNALLY
   COOLED ELECTRODES; LONG-TERM SURVIVAL; QUALITY-OF-LIFE;
   HEPATOCELLULAR-CARCINOMA
AB Image-guided tumor ablation has become a well-established hallmark of local cancer therapy. The breadth of options available in this growing field increases the need for standardization of terminology and reporting criteria to facilitate effective communication of ideas and appropriate comparison among treatments that use different technologies, such as chemical (eg, ethanol or acetic acid) ablation, thermal therapies (eg, radiofrequency, laser, microwave, focused ultrasound, and cryoablation) and newer ablative modalities such as irreversible electroporation. This updated consensus document provides a framework that will facilitate the clearest communication among investigators regarding ablative technologies. An appropriate vehicle is proposed for reporting the various aspects of image-guided ablation therapy including classification of therapies, procedure terms, descriptors of imaging guidance, and terminology for imaging and pathologic findings. Methods are addressed for standardizing reporting of technique, follow-up, complications, and clinical results. As noted in the original document from 2003, adherence to the recommendations will improve the precision of communications in this field, leading to more accurate comparison of technologies and results, and ultimately to improved patient outcomes. (C) RSNA, 2014
C1 [Ahmed, Muneeb] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA.
   [Solbiati, Luigi] Osped Gen, Dept Radiol, Busto Arsizio, Italy.
   [Brace, Christopher L.] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA.
   [Brace, Christopher L.] Univ Wisconsin, Dept Biomed Engn, Sch Med & Publ Hlth, Madison, WI USA.
   [Brace, Christopher L.] Univ Wisconsin, Dept Med Phys, Sch Med & Publ Hlth, Madison, WI 53706 USA.
   [Breen, David J.] Southampton Univ Hosp, Dept Radiol, Southampton, Hants, England.
   [Callstrom, Matthew R.; Charboneau, J. William] Mayo Clin, Dept Radiol, Rochester, MN USA.
   [Chen, Min-Hua] Peking Univ, Dept Ultrasound, Sch Oncol, Beijing 100871, Peoples R China.
   [Choi, Byung Ihn] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea.
   [de Baere, Thierry] Inst Cancerol Gustave Roussy, Dept Imaging, Villejuif, France.
   [Dodd, Gerald D., III] Univ Colorado, Dept Radiol, Sch Med, Aurora, CO USA.
   [Dupuy, Damian E.] Rhode Isl Hosp, Dept Diagnost Radiol, Providence, RI USA.
   [Gervais, Debra A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiol, Boston, MA USA.
   [Gianfelice, David] Univ Hlth Network, Laval, PQ, Canada.
   [Gillams, Alice R.] London Clin, Dept Imaging, London, England.
   [Lee, Fred T., Jr.] Univ Wisconsin Hosp & Clin, Dept Radiol, Madison, WI 53792 USA.
   [Leen, Edward] Royal Infirm, Dept Radiol, Glasgow G31 2ER, Lanark, Scotland.
   [Lencioni, Riccardo] Univ Pisa, Dept Diagnost Imaging & Intervent, Cisanello Hosp, Pisa Univ Hosp, Pisa, Italy.
   [Lencioni, Riccardo] Univ Pisa, Sch Med, I-56100 Pisa, Italy.
   [Littrup, Peter J.] Wayne State Univ, Dept Radiol, Karmonos Canc Inst, Detroit, MI USA.
   [Lu, David S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Los Angeles, CA 90095 USA.
   [McGahan, John P.] UC Davis Med Ctr, Dept Radiol, Ctr Ambulatory Care, Sacramento, CA USA.
   [Meloni, Maria Franca] Osped Valduce, Dept Radiol, Como, Italy.
   [Nikolic, Boris] Albert Einstein Med Ctr, Dept Radiol, Philadelphia, PA 19141 USA.
   [Pereira, Philippe L.] Heidelberg Univ, Clin Radio ,Minimally Invas Therapies & Nucl Med, Acad Hosp, Heilbronn, Germany.
   [Liang, Ping] Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing, Peoples R China.
   [Rhim, Hyunchul] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Diagnost Radiol, Seoul, South Korea.
   [Rose, Steven C.] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA.
   [Salem, Riad] Northwestern Univ, Dept Radiol, Chicago, IL USA.
   [Sofocleous, Constantinos T.; Solomon, Stephen B.] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USA.
   [Soulen, Michael C.] Univ Penn, Dept Radiol, Hosp Univ Penn, Philadelphia, PA 19104 USA.
   [Tanaka, Masatoshi] Yokokura Hosp, Dept Hepatol, Miyama, Japan.
   [Vogl, Thomas J.] Goethe Univ Frankfurt, Inst Diagnost & Intervent Radiol, Univ Hosp Frankfurt, D-60054 Frankfurt, Germany.
   [Wood, Bradford J.] NIH, Bethesda, MD 20892 USA.
   [Goldberg, S. Nahum] Hadassah Hebrew Univ, Med Ctr, Dept, Image Guided Therapy & Intervent Oncol Unit, Jerusalem, Israel.
RP Ahmed, M (reprint author), Beth Israel Deaconess Med Ctr, Dept Radiol, 1 Deaconess Rd,WCC-308B, Boston, MA 02215 USA.
EM mahmed@bidmc.harvard.edu
FU NeuWave Medical; University of Wisconsin; Galil Medical; Siemens
   Medical; GE Medical; Thermedical; Samsung Electronics; Terumo;
   HS-Medical; Boston-Scientific; BSD Medical; Covidien; Springer Verlag;
   UpToDate; Covidien/Valleylab; Endocare; Ethicon Endo-Surgery; Philips;
   Celon Olympus; Siemens Medical Solutions; GE Healthcare; AngioDyamics;
   Guerbet LLC; BTG; Merit Medical; Cooperative Research and Development
   Agreement (CRADA) Philips Healthcare; CRADA Biocompatibles BTG; CRADA
   Perfint; CRADA Celsion; CRADA Invivo; AngioDynamics; Cosman Medical
FX M.A. No relevant conflicts of interest to disclose. L.S. No relevant
   conflicts of interest to disclose. C.L.B. Financial activities related
   to the present article: none to disclose. Financial activities not
   related to the present article: received consultancy fees from NeuWave
   Medical, author and institution received payment for patents (planned,
   pending, or issued) from University of Wisconsin and NeuWave Medical,
   received payment for stock/stock options from NeuWave Medical. Other
   relationships: none to disclose. D.J.B. Financial activities related to
   the present article: paid for occasional proctoring by Galil Medical.
   Financial activities not related to the present article: none to
   disclose. Other relationships: none to disclose. M.R.C. Financial
   activities related to the present article: none to disclose. Financial
   activities not related to the present article: received grants from
   Galil Medical, Siemens Medical, GE Medical, Thermedical. Other
   relationships: none to disclose. J.W.C. No relevant conflicts of
   interest to disclose. M.H.C. No relevant conflicts of interest to
   disclose. B.I.C. Financial activities related to the present article:
   none to disclose. Financial activities not related to the present
   article: institution received a research grant from Samsung Electronics.
   Other relationships: none to disclose. T.d.B. Financial activities
   related to the present article: none to disclose. Financial activities
   not related to the present article: received personal fees from Terumo,
   a grant from HS-Medical, and payment for travel to a meeting from
   Boston-Scientific. Other relationships: none to disclose. G. D. D. No
   relevant conflicts of interest to disclose. D. E. D. Financial
   activities related to the present article: none to disclose. Financial
   activities not related to the present article: paid for board membership
   by BSD Medical, received consultancy fees from BSD Medical and Covidien,
   received grants or has grants pending from NeuWave Medical, received
   payment for lectures including service on speakers bureaus from BSD
   Medical, was paid royalties by Springer Verlag and UpToDate, received
   stock or stock options from BSD Medical,. Other relationships: none to
   disclose. D. A. G. Financial activities related to the present article:
   none to disclose. Financial activities not related to the present
   article: received a research grant from Covidien/Valleylab. Other
   relationships: none to disclose. D. G. No relevant conflicts of interest
   to disclose. A. R. G. Financial activities related to the present
   article: received consulting fee or honorarium from Covidien, received
   fees for participatient in review activities such as data monitoring
   boards, statistical analysis, end point committees, and the like from
   Covidien. Financial activities not related to the present article: was
   paid for board membership, consultancy, and lectures including service
   on speakers bureaus by Covidien. Other relationships: none to disclose.
   F. T. L. Financial activities related to the present article: received
   payment from NeuWave Medical. Financial activities not related to the
   present article: received royalties from Covidien, is a stockholder and
   on the Board of Directors for NeuWave Medical, has a patent on the
   Switching Controller with royalties paid from Covidien, has multiple
   patents on heat-based thermal therapies for microwave ablation systems
   licensed to NeuWave Medical. Other relationships: none to disclose. E.
   L. No relevant conflicts of interest to disclose. R. L. No relevant
   conflicts of interest to disclose. P.J.L.; No relevant conflicts of
   interest to disclose. T. L. No relevant conflicts of interest to
   disclose. D. S. L. Financial activities related to the present article:
   none to disclose. Financial activities not related to the present
   article: institution received grants or has grants pending from Endocare
   and Ethicon Endo-Surgery, received payment for lectures including
   service on speakers bureaus from Philips. Other relationships: none to
   disclose. J.P.M. No relevant conflicts of interest to disclose. M. F. M.
   No relevant conflicts of interest to disclose. B.N. No relevant
   conflicts of interest to disclose. P. L. P. Financial activities related
   to the present article: none to disclose. Financial activities not
   related to the present article: received a grant from Celon Olympus;
   fees for conferences from Siemens Medical Solutions; consultant's
   honoraries from Terumo Europe, Terumo Germany, and Microsulis; materials
   from AngioDynamics. Other relationships: none to disclose. P. L. No
   relevant conflicts of interest to disclose. H. R. No relevant conflicts
   of interest to disclose. S. C. R. No relevant conflicts of interest to
   disclose. R. S. No relevant conflicts of interest to disclose. C. T. S.
   No relevant conflicts of interest to disclose. S. B. S. Financial
   activities related to the present article: institution received a grant
   from GE Healthcare; author received consulting fee or honorarium from
   AngioDyamics, Covidien, and GE Healthcare. Financial activities not
   related to the present article: none to disclose. Other relationships:
   none to disclose. M. C. S. Financial activities related to the present
   article: none to disclose. Financial activities not related to the
   present article: author received consultancy fees from Guerbet LLC, BTG,
   Merit Medical; institution received grants or has grants pending from
   Guerbet LLC and BTG; author received payment for lectures including
   service on speakers bureaus from Sirtex; author received royalties from
   Cambridge University Press. Other relationships: none to disclose. M. T.
   No relevant conflicts of interest to disclose. T.J.V. No relevant
   conflicts of interest to disclose. B.J.W. Financial activities related
   to the present article: none to disclose. Financial activities not
   related to the present article: institution received grants or has
   grants pending from Cooperative Research and Development Agreement
   (CRADA) Philips Healthcare, CRADA Biocompatibles BTG, CRADA Perfint,
   CRADA Celsion, CRADA Invivo; the National Institutes of Health has
   intellectual property in the field. Other relationships: none to
   disclose. S.N.G. Financial activities related to the present article:
   institution received a grant for sponsored research from AngioDynamics;
   author received consulting fee or honorarium from AngioDynamics.
   Financial activities not related to the present article: author received
   consultancy fees from Cosman Medical and institution received grants or
   has grants pending from Cosman Medical. Other relationships: none to
   disclose.
NR 100
TC 96
Z9 100
U1 4
U2 23
PU RADIOLOGICAL SOC NORTH AMERICA
PI OAK BROOK
PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA
SN 0033-8419
J9 RADIOLOGY
JI Radiology
PD OCT
PY 2014
VL 273
IS 1
BP 241
EP 260
DI 10.1148/radiol.14132958
PG 20
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AS4GO
UT WOS:000344232100027
PM 24927329
ER

PT J
AU Johnson, C
   Connors, GR
   Oaks, J
   Han, S
   Truong, A
   Richardson, B
   Lechtzin, N
   Mammen, AL
   Casciola-Rosen, L
   Christopher-Stine, L
   Danoff, SK
AF Johnson, C.
   Connors, G. R.
   Oaks, J.
   Han, S.
   Truong, A.
   Richardson, B.
   Lechtzin, N.
   Mammen, A. L.
   Casciola-Rosen, L.
   Christopher-Stine, L.
   Danoff, S. K.
TI Clinical and pathologic differences in interstitial lung disease based
   on antisynthetase antibody type
SO RESPIRATORY MEDICINE
LA English
DT Article
DE ILD; Dermatomyositis; Polymyositis; Antisynthetase syndrome
ID IDIOPATHIC INFLAMMATORY MYOPATHIES; RESOLUTION COMPUTED-TOMOGRAPHY;
   PULMONARY-FIBROSIS; AMYOPATHIC DERMATOMYOSITIS; ANTINUCLEAR ANTIBODIES;
   POLYMYOSITIS; PREVALENCE; PROGNOSIS; MYOSITIS; MANIFESTATIONS
AB Background: Interstitial lung disease (ILD) is a common extramuscular manifestation of the idiopathic inflammatory myopathies (IIMs), dernnatomyositis (DM) and polymyositis (PM). Patients with antisynthetase antibodies (ASA) demonstrate some or all of the features of the antisynthetase syndrome including IIM and ILD. It has been hypothesized that the clinical expression of antisynthetase syndrome varies between specific ASAs.
   Objective: We sought to determine whether the myositis-associated ILD (MA-ILD) phenotype differs based on the presence of ASAs and by ASA subtype.
   Methods: A cross-sectional and longitudinal analysis of consecutive patients enrolled at the Johns Hopkins Myositis Center with ILD in the setting of clinically diagnosed autoimmune myositis was conducted.
   Results: Seventy-seven subjects were included; 36 were ASA negative, 28 were anti-Jo1 positive, and 13 were non-Jo1 ASA positive (5 anti-PL-12, 4 anti-PL-7, 2 anti-EJ, and 2 anti-OJ). Non-Jo1 ASA positive participants were more likely to be African-American than Caucasian as compared to both the anti-Jo1 positive (p = 0.01) and ASA negative groups (p < 0.01). ASA negative participants had better mean forced vital capacity percent predicted (FVC%) and total computed tomography scores over time compared to those with anti-Jo1 after controlling for potential confounders.
   Conclusions: ASA status was significantly different by race. Those with anti-Jo1 antibodies had worse lung function and CT scores over time compared to those without detectable antisynthetase antibodies. Further prospective study in a larger cohort is needed to determine whether these apparent antibody-specific differences in demographics and manifestations of disease translate into meaningful disparities in clinical outcomes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Johnson, C.; Richardson, B.; Lechtzin, N.; Danoff, S. K.] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD 21205 USA.
   [Connors, G. R.] Yale Univ, Sch Med, Div Pulm Crit Care & Sleep, New Haven, CT 06510 USA.
   [Oaks, J.] Reston Radiol Consultants PC, Reston, VA 20190 USA.
   [Han, S.] Univ Pittsburgh, Med Ctr, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA.
   [Han, S.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
   [Truong, A.] Emory Univ, Hosp Midtown, Emory Univ Hosp, Atlanta, GA 30308 USA.
   [Mammen, A. L.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21224 USA.
   [Mammen, A. L.] NIAMSD, Muscle Dis Unit, Lab Muscle Stem Cells & Gene Express, NIH, Bethesda, MD 20892 USA.
   [Casciola-Rosen, L.; Christopher-Stine, L.] Johns Hopkins Univ, Sch Med, Div Rheumatol, Baltimore, MD 21224 USA.
RP Danoff, SK (reprint author), Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, 1830 E Monument St Suite 500, Baltimore, MD 21205 USA.
EM sdanoff@jhmi.edu
NR 30
TC 9
Z9 9
U1 0
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD OCT
PY 2014
VL 108
IS 10
BP 1542
EP 1548
DI 10.1016/j.rmed.2014.09.003
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System
SC Cardiovascular System & Cardiology; Respiratory System
GA AS7GO
UT WOS:000344425300017
PM 25269710
ER

PT J
AU Yutin, N
   Wolf, YI
   Koonin, EV
AF Yutin, Natalya
   Wolf, Yuri I.
   Koonin, Eugene V.
TI Origin of giant viruses from smaller DNA viruses not from a fourth
   domain of cellular life
SO VIROLOGY
LA English
DT Article
DE Giant viruses; Genome evolution; Domains of cellular life; Genome
   evolution; Phylogenomics
ID EVOLUTIONARY GENOMICS; PHYLOGENETIC FOREST; ORTHOLOGOUS GENES; VACCINIA
   VIRUS; MIMIVIRUS; EUKARYOTES; CLUSTERS; ARCHAEA; TREE; RECONSTRUCTION
AB The numerous and diverse eukaryotic viruses with large double-stranded DNA genomes that at least partially reproduce in the cytoplasm of infected cells apparently evolved from a single virus ancestor. This major group of viruses is known as Nucleocytoplasmic Large DNA Viruses (NCLDV) or the proposed order Megavirales. Among the "Megavirales", there are three groups of giant viruses with genomes exceeding 500 kb, namely Mimiviruses, Pithoviruses, and Pandoraviruses that hold the current record of viral genome size, about 2.5 Mb. Phylogenetic analysis of conserved, ancestral NLCDV genes clearly shows that these three groups of giant viruses have three distinct origins within the "Megavirales". The Mimiviruses constitute a distinct family that is distantly related to Phycodnaviridae, Pandoraviruses originate from a common ancestor with Coccolithoviruses within the Phycodnaviridae family, and Pithoviruses are related to Iridoviridae and Marseilleviridae. Maximum likelihood reconstruction of gene gain and loss events during the evolution of the "Megavirales" indicates that each group of giant viruses evolved from viruses with substantially smaller and simpler gene repertoires. Initial phylogenetic analysis of universal genes, such as translation system components, encoded by some giant viruses, in particular Mimiviruses, has led to the hypothesis that giant viruses descend from a fourth, probably extinct domain of cellular life. The results of our comprehensive phylogenomic analysis of giant viruses refute the fourth domain hypothesis and instead indicate that the universal genes have been independently acquired by different giant viruses from their eukaryotic hosts. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
C1 [Yutin, Natalya; Wolf, Yuri I.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Koonin, EV (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
EM koonin@ncbi.nlm.nih.gov
FU US Department of health and Human Services
FX We thank Mart Krupovic for critical reading of the manuscript and
   helpful suggestions. The authors' research is supported by intramural
   funds of the US Department of health and Human Services (to the National
   Library of Medicine).
NR 73
TC 35
Z9 35
U1 3
U2 44
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD OCT
PY 2014
VL 466
BP 38
EP 52
DI 10.1016/j.virol.2014.06.032
PG 15
WC Virology
SC Virology
GA AS3XL
UT WOS:000344208400005
PM 25042053
ER

PT J
AU Marino, N
   Collins, JW
   Shen, CY
   Caplen, NJ
   Merchant, AS
   Gokmen-Polar, Y
   Goswami, CP
   Hoshino, T
   Qian, YZ
   Sledge, GW
   Steeg, PS
AF Marino, Natascia
   Collins, Joshua W.
   Shen, Changyu
   Caplen, Natasha J.
   Merchant, Anand S.
   Goekmen-Polar, Yesim
   Goswami, Chirayu P.
   Hoshino, Takashi
   Qian, Yongzhen
   Sledge, George W., Jr.
   Steeg, Patricia S.
TI Identification and validation of genes with expression patterns inverse
   to multiple metastasis suppressor genes in breast cancer cell lines
SO CLINICAL & EXPERIMENTAL METASTASIS
LA English
DT Article
DE Metastasis suppressor genes; Metastasis; Gene expression profiling;
   Bioinformatics; PDE5A; Breast cancer
ID DEPENDENT PROTEIN-KINASE; HUMAN OVARIAN-CARCINOMA; ACID RECEPTOR EDG2;
   PROSTATE-CANCER; INTERLEUKIN-11 RECEPTOR; CGMP-BINDING; CYCLIC-GMP;
   E-CADHERIN; IN-VIVO; DYNAMIN
AB Metastasis suppressor genes (MSGs) have contributed to an understanding of regulatory pathways unique to the lethal metastatic process. When re-expressed in experimental models, MSGs block cancer spread to, and colonization of distant sites without affecting primary tumor formation. Genes have been identified with expression patterns inverse to a single MSG, and found to encode functional, druggable signaling pathways. We now hypothesize that common signaling pathways mediate the effects of multiple MSGs. By gene expression profiling of human MCF7 breast carcinoma cells expressing a scrambled siRNA, or siRNAs to each of 19 validated MSGs (NME1, BRMS1, CD82, CDH1, CDH2, CDH11, CASP8, MAP2K4, MAP2K6, MAP2K7, MAPK14, GSN, ARHGDIB, AKAP12, DRG1, CD44, PEBP1, RRM1, KISS1), we identified genes whose expression was significantly opposite to at least five MSGs. Five genes were selected for further analysis: PDE5A, UGT1A, IL11RA, DNM3 and OAS1. After stable downregulation of each candidate gene in the aggressive human breast cancer cell line MDA-MB-231T, in vitro motility was significantly inhibited. Two stable clones downregulating PDE5A (phosphodiesterase 5A), an enzyme involved in the regulation of cGMP-specific signaling, exhibited no difference in cell proliferation, but reduced motility by 47 and 66 % compared to the empty vector-expressing cells (p = 0.01 and p = 0.005). In an experimental metastasis assay, two shPDE5A-MDA-MB-231T clones produced 47-62 % fewer lung metastases than shRNA-scramble expressing cells (p = 0.045 and p = 0.009 respectively). This study demonstrates that previously unrecognized genes are inversely related to the expression of multiple MSGs, contribute to aspects of metastasis, and may stand as novel therapeutic targets.
C1 [Marino, Natascia; Collins, Joshua W.; Steeg, Patricia S.] NCI, Womens Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Shen, Changyu] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
   [Caplen, Natasha J.] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Merchant, Anand S.] Leidos Biomed, Adv Biomed Comp Ctr, CCRIFX Bioinformat Core, Frederick, MD USA.
   [Goekmen-Polar, Yesim] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.
   [Goswami, Chirayu P.] Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA.
   [Hoshino, Takashi] Takeda Pharmaceut Co Ltd, Tsukuba, Ibaraki, Japan.
   [Qian, Yongzhen] NCI, Lab Anim Sci Program, SAIC Frederick, Frederick, MD 21701 USA.
   [Sledge, George W., Jr.] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
RP Marino, N (reprint author), NCI, Womens Malignancies Branch, Ctr Canc Res, Bldg 37,Room 1126,37 Convent Dr, Bethesda, MD 20892 USA.
EM natasciam28@gmail.com; steegp@mail.nih.gov
RI Caplen, Natasha/H-2768-2016; 
OI Caplen, Natasha/0000-0002-0001-9460; Gokmen-Polar,
   Yesim/0000-0001-9927-4893
FU Intramural program of the National Cancer Institute; Breast Cancer
   Research Stamp Fund through National Cancer Institute; NCI Center for
   Cancer Research
FX This work was supported by the Intramural program of the National Cancer
   Institute and Breast Cancer Research Stamp Fund awarded through
   competitive peer review by National Cancer Institute (to PSS). The
   authors would like to acknowledge Manjula Kasoji and Dr Fathi Elloumi of
   the CCRIFX Bioinformatics Core operated by Leidos Biomedical Research,
   Inc and funded by the NCI Center for Cancer Research for their
   contributions to the bioinformatics analysis.
NR 90
TC 5
Z9 5
U1 1
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0262-0898
EI 1573-7276
J9 CLIN EXP METASTAS
JI Clin. Exp. Metastasis
PD OCT
PY 2014
VL 31
IS 7
BP 771
EP 786
DI 10.1007/s10585-014-9667-0
PG 16
WC Oncology
SC Oncology
GA AR9IH
UT WOS:000343886600003
PM 25086928
ER

PT J
AU Decker, BK
   Palmore, TN
AF Decker, Brooke K.
   Palmore, Tara N.
TI Hospital Water and Opportunities for Infection Prevention
SO CURRENT INFECTIOUS DISEASE REPORTS
LA English
DT Article
DE Nosocomial; Waterborne; Legionella
ID NOSOCOMIAL LEGIONNAIRES-DISEASE; LEGIONELLA-PNEUMOPHILA CONTAMINATION;
   BURKHOLDERIA-CEPACIA COMPLEX; MYCOBACTERIUM-AVIUM COMPLEX;
   CARE-ASSOCIATED INFECTIONS; NON-TOUCH FITTINGS; PSEUDOMONAS-AERUGINOSA;
   POTABLE WATER; NONTUBERCULOUS MYCOBACTERIA; AEROMONAS-HYDROPHILA
AB Nosocomial waterborne pathogens may reach patients through several modes of transmission. Colonization of healthcare facility waterworks can occur in the proximal infrastructure, in the distal water outlets, or both. Infections with waterborne organisms such as Legionella, mycobacteria, Pseudomonas, and others cause significant morbidity and mortality, particularly in immunocompromised patients. Hospitals should have prospective water safety plans that include preventive measures, as prevention is preferable to remediation of contaminated hospital water distribution systems. Whole-genome sequencing may provide more informative epidemiologic data to link patient infections with hospital water isolates.
C1 [Decker, Brooke K.; Palmore, Tara N.] NIH, Ctr Clin, Bethesda, MD 20892 USA.
RP Palmore, TN (reprint author), NIH, Ctr Clin, 10 Ctr Dr,12C103A, Bethesda, MD 20892 USA.
EM tpalmore@mail.nih.gov
OI Decker M.D., Brooke K/0000-0002-3404-9115
FU Intramural Research Program of the NIH Clinical Center
FX This work was supported by the Intramural Research Program of the NIH
   Clinical Center.
NR 82
TC 5
Z9 5
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3847
EI 1534-3146
J9 CURR INFECT DIS REP
JI Curr. Infect. Dis. Rep.
PD OCT
PY 2014
VL 16
IS 10
AR 432
DI 10.1007/s11908-014-0432-y
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA AS0HM
UT WOS:000343958600007
PM 25217106
ER

PT J
AU Newmeyer, MN
   Desrosiers, NA
   Lee, D
   Mendu, DR
   Barnes, AJ
   Gorelick, DA
   Huestis, MA
AF Newmeyer, Matthew N.
   Desrosiers, Nathalie A.
   Lee, Dayong
   Mendu, Damodara R.
   Barnes, Allan J.
   Gorelick, David A.
   Huestis, Marilyn A.
TI Cannabinoid disposition in oral fluid after controlled cannabis smoking
   in frequent and occasional smokers
SO DRUG TESTING AND ANALYSIS
LA English
DT Article
DE oral fluid; Oral-Eze (R); cannabinoids
ID PHARMACOKINETIC PROPERTIES; DELTA(9)-TETRAHYDROCANNABINOL; PLASMA;
   METABOLITES; MARIJUANA; URINE; USERS; DRUGS; SERUM
AB Oral fluid (OF) is an increasingly popular alternative matrix for drug testing, with cannabinoids being the most commonly identified illicit drug. Quantification of multiple OF cannabinoids and understanding differences in OF cannabinoid pharmacokinetics between frequent and occasional smokers improve test interpretation. The new Oral-Eze (R) OF collection device has an elution buffer that stabilizes analytes and improves drug recovery from the collection pad; however, its performance has not been independently evaluated. After controlled smoking of a 6.8% (9)-tetrahydrocannabinol (THC) cannabis cigarette by frequent and occasional smokers, OF was collected with the Oral-Eze device for up to 30 h. Samples were analyzed for multiple cannabinoids by a validated 2D-GC-MS method. Frequent smokers had significantly greater OF THCCOOH concentrations than occasional smokers at all times, and showed positive results for a significantly longer time. We evaluated multiple cannabinoid cut-offs; the shortest last detection times were observed when THC 1g/L was combined with CBD or CBN 1g/L. With these cut-offs, last detection times(1-13.5 h) were not significantly different between groups, demonstrating suitability for short-term cannabinoid detection independent of smoking history. Cut-offs utilizing THC alone or combined with THCCOOH showed significantly different last detection times between groups. The widest detection windows were observed with THC 1 or 2g/L or THCCOOH 20ng/L. Our data illustrate the effectiveness of the Oral-Eze (R) device for OF collection, the impact of self-administered smoked cannabis history on OF cannabinoid results, and the ability to improve interpretation and tailor OF cannabinoid cut-offs to fulfill the detection window needs of a given program. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Newmeyer, Matthew N.; Desrosiers, Nathalie A.; Lee, Dayong; Mendu, Damodara R.; Barnes, Allan J.; Gorelick, David A.; Huestis, Marilyn A.] NIDA, Chem & Drug Metab Sect, IRP, NIH, Baltimore, MD 21224 USA.
   [Newmeyer, Matthew N.; Desrosiers, Nathalie A.; Lee, Dayong] Univ Maryland, Toxicol Program, Baltimore, MD 21201 USA.
RP Huestis, MA (reprint author), NIDA, Intramural Res Program, NIH, 251 Bayview Blvd,Suite 200 Room 05A-721, Baltimore, MD 21224 USA.
EM mhuestis@intra.nida.nih.gov
OI Newmeyer, Matthew/0000-0002-0653-1553
FU NIDA Intramural Research Program, NIH
FX Funding for this study was provided by NIDA Intramural Research Program,
   NIH. We acknowledge contributions of the clinical staffs of the NIDA
   Intramural Research Program, and Behavioral Pharmacology Research Unit
   and Clinical Research Unit, Johns Hopkins Bayview Medical Center, as
   well as Drs. David M. Schwope, Sebastien Anizan, Marta Concheiro, and
   Mateus Bergamaschi, and the Graduate Partnership Program, NIH.
NR 26
TC 10
Z9 10
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-7603
EI 1942-7611
J9 DRUG TEST ANAL
JI Drug Test. Anal.
PD OCT
PY 2014
VL 6
IS 10
BP 1002
EP 1010
DI 10.1002/dta.1632
PG 9
WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology &
   Pharmacy
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA AR8GX
UT WOS:000343814800005
PM 24652685
ER

PT J
AU Hosgood, HD
   Sapkota, AR
   Rothman, N
   Rohan, T
   Hu, W
   Xu, J
   Vermeulen, R
   He, XZ
   White, JR
   Wu, GP
   Wei, FS
   Mongodin, EF
   Lan, Q
AF Hosgood, H. Dean, III
   Sapkota, Amy R.
   Rothman, Nathaniel
   Rohan, Thomas
   Hu, Wei
   Xu, Jun
   Vermeulen, Roel
   He, Xingzhou
   White, James Robert
   Wu, Guoping
   Wei, Fusheng
   Mongodin, Emmanuel F.
   Lan, Qing
TI The Potential Role of Lung Microbiota in Lung Cancer Attributed to
   Household Coal Burning Exposures
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE lung microbiota; 16S; carcinogenesis; lung cancer; bacteria;
   respiratory; pulmonary
ID POLYCYCLIC AROMATIC-HYDROCARBONS; OBSTRUCTIVE PULMONARY-DISEASE;
   XUAN-WEI COUNTY; COMBUSTION EMISSIONS; CURRENT PROGRESS; CHINA; RISK;
   MORTALITY; EPIDEMIOLOGY; INFLAMMATION
AB Bacteria influence site-specific disease etiology and the host's ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs). Lung cancer in Xuanwei, China has been attributed to PAH-rich household air pollution from burning coal. This study seeks to explore the role of lung microbiota in lung cancer among never smoking Xuanwei women and how coal burning may influence these associations. DNA from sputum and buccal samples of never smoking lung cancer cases (n = 8, in duplicate) and controls (n = 8, in duplicate) in two Xuanwei villages was extracted using a multi-step enzymatic and physical lysis, followed by a standardized clean-up. V1-V2 regions of 16S rRNA genes were PCR-amplified. Purified amplicons were sequenced by 454 FLX Titanium pyrosequencing and high-quality sequences were evaluated for diversity and taxonomic membership. Bacterial diversity among cases and controls was similar in buccal samples (P = 0.46), but significantly different in sputum samples (P = 0.038). In sputum, Granulicatella (6.1 vs. 2.0%; P = 0.0016), Abiotrophia (1.5 vs. 0.085%; P = 0.0036), and Streptococcus (40.1 vs. 19.8%; P = 0.0142) were enriched in cases compared with controls. Sputum samples had on average 488.25 species-level OTUs in the flora of cases who used smoky coal (PAH-rich) compared with 352.5 OTUs among cases who used smokeless coal (PAH-poor; P = 0.047). These differences were explained by the Bacilli species (Streptococcus infantis and Streptococcus anginosus). Our small study suggests that never smoking lung cancer cases have differing sputum microbiota than controls. Further, bacteria found in sputum may be influenced by environmental exposures associated with the type of coal burned in the home. (C) 2014 Wiley Periodicals, Inc.
C1 [Hosgood, H. Dean, III; Rohan, Thomas] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.
   [Hosgood, H. Dean, III; Rothman, Nathaniel; Hu, Wei; Lan, Qing] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
   [Sapkota, Amy R.] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA.
   [Xu, Jun] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
   [Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TC Utrecht, Netherlands.
   [He, Xingzhou] Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Engn, Beijing, Peoples R China.
   [White, James Robert; Mongodin, Emmanuel F.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
   [Wu, Guoping; Wei, Fusheng] China Natl Environm Monitoring Ctr, Beijing, Peoples R China.
RP Hosgood, HD (reprint author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Div Epidemiol, 1300 Morris Pk Ave,Belfer 1309, Bronx, NY 10461 USA.
EM dean.hosgood@einstein.yu.edu
RI Sapkota, Amy/A-6046-2011; Vermeulen, Roel/F-8037-2011
OI Vermeulen, Roel/0000-0003-4082-8163
FU Intramural NIH HHS [Z99 CA999999]; NCI NIH HHS [N01CO12400,
   N01-CO-12400]
NR 51
TC 6
Z9 6
U1 1
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD OCT
PY 2014
VL 55
IS 8
BP 643
EP 651
DI 10.1002/em.21878
PG 9
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AR8KK
UT WOS:000343823800005
PM 24895247
ER

PT J
AU Bassig, BA
   Zhang, LP
   Cawthon, RM
   Smith, MT
   Yin, SN
   Li, GL
   Hu, W
   Shen, M
   Rappaport, S
   Barone-Adesi, F
   Rothman, N
   Vermeulen, R
   Lan, Q
AF Bassig, Bryan A.
   Zhang, Luoping
   Cawthon, Richard M.
   Smith, Martyn T.
   Yin, Songnian
   Li, Guilan
   Hu, Wei
   Shen, Min
   Rappaport, Stephen
   Barone-Adesi, Francesco
   Rothman, Nathaniel
   Vermeulen, Roel
   Lan, Qing
TI Alterations in Leukocyte Telomere Length in Workers Occupationally
   Exposed to Benzene
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE benzene; telomere length; telomeres; occupational exposure
ID CELLS IN-VITRO; PERIPHERAL-BLOOD; CHINESE WORKERS; CANCER;
   HEMATOTOXICITY; ASSOCIATION; DYSFUNCTION; EXPRESSION; POLLUTION;
   LYMPHOMA
AB Exposure to benzene, a known leukemogen and probable lymphomagen, has been demonstrated to result in oxidative stress, which has previously been associated with altered telomere length (TL). TL specifically has been associated with several health outcomes in epidemiologic studies, including cancer risk, and has been demonstrated to be altered following exposure to a variety of chemical agents. To evaluate the association between benzene exposure and TL, we measured TL by monochrome multiplex quantitative PCR in 43 workers exposed to high levels of benzene and 43 age and sex-matched unexposed workers in Shanghai, China. Benzene exposure levels were monitored using organic vapor passive dosimetry badges before phlebotomy. The median benzene exposure level in exposed workers was 31 ppm. The mean TL in controls, workers exposed to levels of benzene below the median (<= 31 ppm), and above the median (>31 ppm) was 1.26 +/- 0.17, 1.25 +/- 0.16, and 1.37 +/- 0.23, respectively. Mean TL was significantly elevated in workers exposed to >31 ppm of benzene compared with controls (P = 0.03). Our findings provide evidence that high levels of occupational benzene exposure are associated with TL. Environ. Mol. Mutagen. Published [2014]. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Bassig, Bryan A.; Hu, Wei; Shen, Min; Rothman, Nathaniel; Lan, Qing] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
   [Zhang, Luoping; Smith, Martyn T.; Rappaport, Stephen] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
   [Cawthon, Richard M.] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
   [Yin, Songnian; Li, Guilan] Chinese Ctr Dis Control & Prevent, Inst Occupat Hlth & Poison Control, Beijing, Peoples R China.
   [Barone-Adesi, Francesco] St Georges Univ London, Div Populat Hlth Sci & Educ, London, England.
   [Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
RP Bassig, BA (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, DHHS 9609 Med Ctr Dr Rm 6-E634,MSC 9771, Bethesda, MD 20892 USA.
EM bassigb@mail.nih.gov
RI Vermeulen, Roel/F-8037-2011
OI Vermeulen, Roel/0000-0003-4082-8163
FU NIEHS NIH HHS [P42 ES004705]
NR 30
TC 4
Z9 5
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD OCT
PY 2014
VL 55
IS 8
BP 673
EP 678
DI 10.1002/em.21880
PG 6
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AR8KK
UT WOS:000343823800008
PM 24945723
ER

PT J
AU Hillesund, ER
   Overby, NC
   Engel, SM
   Klungsoyr, K
   Harmon, QE
   Haugen, M
   Bere, E
AF Hillesund, Elisabet Rudjord
   Overby, Nina C.
   Engel, Stephanie M.
   Klungsoyr, Kari
   Harmon, Quaker E.
   Haugen, Margaretha
   Bere, Elling
TI Associations of adherence to the New Nordic Diet with risk of
   preeclampsia and preterm delivery in the Norwegian Mother and Child
   Cohort Study (MoBa)
SO EUROPEAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Nordic diet; Pregnancy; Preeclampsia; Preterm delivery; Dietary pattern;
   Diet
ID MEDITERRANEAN-TYPE DIET; PREGNANT-WOMEN; BIRTH; NORWAY; EPIDEMIOLOGY;
   INFLAMMATION; NUTRITION; VALIDITY; OUTCOMES; DISEASE
AB Preeclampsia and preterm delivery are serious complications of pregnancy and leading causes of perinatal mortality and morbidity worldwide. Dietary factors might be associated with these adverse outcomes. We investigated whether adherence to the New Nordic Diet (NND) was associated with preeclampsia and preterm delivery risks in the Norwegian Mother and Child Cohort Study (MoBa). Participants were recruited from all over Norway during the period 1999-2008. A previously constructed diet score assessing meal frequency, and the consumption of Nordic fruits, root vegetables, cabbages, potatoes, oatmeal porridge, whole grains, wild fish, game, berries, milk and water, was used to assess NND adherence. Associations between NND adherence and the outcomes were estimated in adjusted multivariate logistic regression models. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated. A total of 72,072 women was included in the study. High versus low NND adherence was associated with lower risk of total preeclampsia (OR 0.86; 95 % CI 0.78-0.95) and early preeclampsia (OR 0.71; 95 % CI 0.52-0.96). High compared with low NND adherence was associated with a lower risk of spontaneous preterm delivery among nulliparous women (OR 0.77; 95 % CI 0.66-0.89), whereas multiparous women with high NND adherence had a marginally significant higher risk of preterm delivery (OR 1.24; 95 % CI 1.00-1.53). High NND adherence was associated with a lower relative risk of preeclampsia and of spontaneous preterm delivery among nulliparous women; however, among multiparous women there was a higher relative risk of preterm delivery.
C1 [Hillesund, Elisabet Rudjord; Overby, Nina C.; Bere, Elling] Univ Agder, Dept Publ Hlth Sport & Nutr, Kristiansand, Norway.
   [Engel, Stephanie M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   [Klungsoyr, Kari] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
   [Harmon, Quaker E.] NIEHS, Epidemiol Branch, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
   [Haugen, Margaretha] Norwegian Inst Publ Hlth, Div Environm Med, Oslo, Norway.
RP Hillesund, ER (reprint author), Univ Agder, Dept Publ Hlth Sport & Nutr, Kristiansand, Norway.
EM elisabet.r.hillesund@uia.no
OI Harmon, Quaker/0000-0002-5866-848X
FU Norwegian Ministry of Health; Ministry of Education and Research; USA
   National Institute of Health (NIH)/National Institute of Environmental
   Health Sciences (NIEHS) [N01-ES-75558]; USA NIH/National Institute of
   Neurological Disorders and Stroke (NINDS) [1 UO1 NS 047537-01, 2 UO1 NS
   047537-06A1]; Norwegian Research Council/FUGE [151918/S10]; NIH,
   National Institute of Environmental Health Sciences, USA; University of
   Agder, Norway
FX We are grateful to all the participating families in Norway who took
   part in this ongoing cohort study. The Norwegian Mother and Child Cohort
   Study was supported by the Norwegian Ministry of Health and the Ministry
   of Education and Research; the USA National Institute of Health
   (NIH)/National Institute of Environmental Health Sciences (NIEHS)
   (Contract No. N01-ES-75558), the USA NIH/National Institute of
   Neurological Disorders and Stroke (NINDS) (Grant No. 1 UO1 NS 047537-01
   and Grant No. 2 UO1 NS 047537-06A1), and the Norwegian Research
   Council/FUGE (Grant No. 151918/S10). This research was supported in part
   by the Intramural Research Program of the NIH, National Institute of
   Environmental Health Sciences, USA. The present study was funded by the
   University of Agder, Norway. None of the funders had any role in the
   design, analysis or writing of this article.
NR 46
TC 8
Z9 8
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0393-2990
EI 1573-7284
J9 EUR J EPIDEMIOL
JI Eur. J. Epidemiol.
PD OCT
PY 2014
VL 29
IS 10
BP 753
EP 765
DI 10.1007/s10654-014-9948-6
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AR9IM
UT WOS:000343887200006
PM 25193741
ER

PT J
AU Wright, PW
   Li, H
   Huehn, A
   O'Connor, GM
   Cooley, S
   Miller, JS
   Anderson, SK
AF Wright, P. W.
   Li, H.
   Huehn, A.
   O'Connor, G. M.
   Cooley, S.
   Miller, J. S.
   Anderson, S. K.
TI Characterization of a weakly expressed KIR2DL1 variant reveals a novel
   upstream promoter that controls KIR expression
SO GENES AND IMMUNITY
LA English
DT Article
ID NATURAL-KILLER-CELLS; IG-LIKE RECEPTOR; GENE-EXPRESSION; NK CELLS;
   PERIPHERAL-BLOOD; DNA METHYLATION; IDENTIFICATION; TRANSCRIPTS; BINDING;
   FAMILY
AB Members of the human KIR (killer cell innmunoglobulin-like receptor) class I major histocompatibility complex receptor gene family contain multiple promoters that determine the variegated expression of KIR on natural killer cells. In order to identify novel genetic alterations associated with decreased KIR expression, a group of donors was characterized for KIR gene content, transcripts and protein expression. An individual with a single copy of the KIR2DL1 gene but a very low level of gene expression was identified. The low expression phenotype was associated with a single-nucleotide polymorphism (SNP) that created a binding site for the inhibitory ZEB1 (Zinc finger E-box-binding homeobox 1) transcription factor adjacent to a c-Myc binding site previously implicated in distal promoter activity. Individuals possessing this SNP had a substantial decrease in distal KIR2DL1 transcripts initiating from a novel intermediate promoter located 230 bp upstream of the proximal promoter start site. Surprisingly, there was no decrease in transcription from the KIR2DL1 proximal promoter. Reduced intermediate promoter activity revealed the existence of alternatively spliced KIR2DL1 transcripts containing premature termination codons that initiated from the proximal KIR2DL1 promoter. Altogether, these results indicate that distal transcripts are necessary for KIR2DL1 protein expression and are required for proper processing of sense transcripts from the bidirectional proximal promoter.
C1 [Wright, P. W.; Li, H.; Anderson, S. K.] Leidos Biomed Res Inc, Frederick Natl Lab, Expt Immunol Lab, Basic Sci Program, Frederick, MD 21702 USA.
   [Huehn, A.; O'Connor, G. M.; Anderson, S. K.] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21701 USA.
   [Cooley, S.; Miller, J. S.] Univ Minnesota, Div Hematol Oncol & Transplantat, Minneapolis, MN USA.
RP Anderson, SK (reprint author), Leidos Biomed Res Inc, Frederick Natl Lab, Expt Immunol Lab, Basic Sci Program, Bldg 560,Room 31-93, Frederick, MD 21702 USA.
EM andersonst@mail.nih.gov
OI Miller, Jeffrey S/0000-0002-0339-4944
FU National Cancer Institute (NCI), NIH [HHSN261200800001E]; NCI [P01
   111412]; NIH, NCI, Center for Cancer Research
FX This project has been funded in whole or in part with federal funds from
   the National Cancer Institute (NCI), NIH, under contract
   HHSN261200800001E and NCI grant P01 111412 (to JSM and SKA). This
   research was supported in part by the Intramural Research Program of the
   NIH, NCI, Center for Cancer Research. The content of this publication
   does not necessarily reflect the views or policies of the Department of
   Health and Human Services, nor does mention of trade names, commercial
   products or organizations imply endorsement by the US Government.
NR 30
TC 3
Z9 3
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-4879
EI 1476-5470
J9 GENES IMMUN
JI Genes Immun.
PD OCT-NOV
PY 2014
VL 15
IS 7
BP 440
EP 448
DI 10.1038/gene.2014.34
PG 9
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA AS0IG
UT WOS:000343960500002
PM 24989671
ER

PT J
AU Edskes, HK
   Khamar, HJ
   Winchester, CL
   Greenler, AJ
   Zhou, A
   McGlinchey, RP
   Gorkovskiy, A
   Wickner, RB
AF Edskes, Herman K.
   Khamar, Hima J.
   Winchester, Chia-Lin
   Greenler, Alexandria J.
   Zhou, Albert
   McGlinchey, Ryan P.
   Gorkovskiy, Anton
   Wickner, Reed B.
TI Sporadic Distribution of Prion-Forming Ability of Sup35p from Yeasts and
   Fungi
SO GENETICS
LA English
DT Article
DE [PSI plus ] prion; Schizosaccharomyces pombe; Ashbya gossypii;
   cytoduction
ID BETA-SHEET STRUCTURE; DE-NOVO APPEARANCE; SACCHAROMYCES-CEREVISIAE;
   TRANSLATION TERMINATION; PSI+ PRION; SPECIES BARRIER; IN-VITRO;
   SCHIZOSACCHAROMYCES-POMBE; GUANIDINE-HYDROCHLORIDE; ENVIRONMENTAL-STRESS
AB Sup35p of Saccharomyces cerevisiae can form the [PSI+] prion, an infectious amyloid in which the protein is largely inactive. The part of Sup35p that forms the amyloid is the region normally involved in control of mRNA turnover. The formation of [PSI+] by Sup35p's from other yeasts has been interpreted to imply that the prion-forming ability of Sup35p is conserved in evolution, and thus of survival/fitness/evolutionary value to these organisms. We surveyed a larger number of yeast and fungal species by the same criteria as used previously and find that the Sup35p from many species cannot form prions. [PSI+] could be formed by the Sup35p from Candida albicans, Candida maltosa, Debaromyces hansenii, and Kluyveromyces lactis, but orders of magnitude less often than the S. cerevisiaeSup35p converts to the prion form. The Sup35s from Schizosaccharomyces pombe and Ashbya gossypii clearly do not form [PSI+]. We were also unable to detect [PSI+] formation by the Sup35ps from Aspergillus nidulans, Aspergillus fumigatus, Magnaporthe grisea, Ustilago maydis, or Cryptococcus neoformans. Each of two C. albicans SUP35 alleles can form [PSI+], but transmission from one to the other is partially blocked. These results suggest that the prion-forming ability of Sup35p is not a conserved trait, but is an occasional deleterious side effect of a protein domain conserved for another function.
C1 [Edskes, Herman K.; Khamar, Hima J.; Winchester, Chia-Lin; Greenler, Alexandria J.; Zhou, Albert; McGlinchey, Ryan P.; Gorkovskiy, Anton; Wickner, Reed B.] NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA.
RP Edskes, HK (reprint author), NIH, Bldg 8,Room 225,8 Ctr Dr,MSC 0830, Bethesda, MD 20892 USA.
EM hermane@helix.nih.gov
RI Gorkovskiy, Anton/J-8930-2016
OI Gorkovskiy, Anton/0000-0003-4811-2282
FU National Institute of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health
FX This work was supported by the Intramural Program of the National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institutes of Health.
NR 82
TC 8
Z9 8
U1 2
U2 11
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 0016-6731
EI 1943-2631
J9 GENETICS
JI Genetics
PD OCT
PY 2014
VL 198
IS 2
BP 605
EP U236
DI 10.1534/genetics.114.166538
PG 27
WC Genetics & Heredity
SC Genetics & Heredity
GA AR9HX
UT WOS:000343885300023
PM 25081567
ER

PT J
AU Rutledge, H
   Aylor, DL
   Carpenter, DE
   Peck, BC
   Chines, P
   Ostrowski, LE
   Chesler, EJ
   Churchill, GA
   Villena, FPM
   Kelada, SNP
AF Rutledge, Holly
   Aylor, David L.
   Carpenter, Danielle E.
   Peck, Bailey C.
   Chines, Peter
   Ostrowski, Lawrence E.
   Chesler, Elissa J.
   Churchill, Gary A.
   de Villena, Fernando Pardo-Manuel
   Kelada, Samir N. P.
TI Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in
   Murine Lung
SO GENETICS
LA English
DT Article
DE asthma; CXCL1; neutrophil; expression quantitative trait locus (eQTL);
   systems genetics; complex traits; Multiparent Advanced Generation
   Inter-Cross (MAGIC); multiparental populations; MPP
ID QUANTITATIVE TRAIT LOCI; COLLABORATIVE CROSS; AIRWAY
   HYPERRESPONSIVENESS; SEVERE ASTHMA; CHEMOKINE KC; EXPRESSION; MOUSE;
   MICE; DISEASE; GENOME
AB Allergic asthma is a complex disease characterized in part by granulocytic inflammation of the airways. In addition to eosinophils, neutrophils (PMN) are also present, particularly in cases of severe asthma. We sought to identify the genetic determinants of neutrophilic inflammation in a mouse model of house dust mite (HDM)-induced asthma. We applied an HDM model of allergic asthma to the eight founder strains of the Collaborative Cross (CC) and 151 incipient lines of the CC (preCC). Lung lavage fluid was analyzed for PMN count and the concentration of CXCL1, a hallmark PMN chemokine. PMN and CXCL1 were strongly correlated in preCC mice. We used quantitative trait locus (QTL) mapping to identify three variants affecting PMN, one of which colocalized with a QTL for CXCL1 on chromosome (Chr) 7. We used lung eQTL data to implicate a variant in the gene Zfp30 in the CXCL1/PMN response. This genetic variant regulates both CXCL1 and PMN by altering Zfp30 expression, and we model the relationships between the QTL and these three endophenotypes. We show that Zfp30 is expressed in airway epithelia in the normal mouse lung and that altering Zfp30 expression in vitro affects CXCL1 responses to an immune stimulus. Our results provide strong evidence that Zfp30 is a novel regulator of neutrophilic airway inflammation.
C1 [Rutledge, Holly; de Villena, Fernando Pardo-Manuel; Kelada, Samir N. P.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
   [Aylor, David L.] N Carolina State Univ, Dept Biol, Raleigh, NC 27695 USA.
   [Carpenter, Danielle E.; Peck, Bailey C.; Chines, Peter] NHGRI, NIH, Bethesda, MD 20892 USA.
   [Ostrowski, Lawrence E.; Kelada, Samir N. P.] Univ N Carolina, Marsico Lung Inst, Chapel Hill, NC 27599 USA.
   [Chesler, Elissa J.; Churchill, Gary A.] Jackson Lab, Bar Harbor, ME 04609 USA.
   Univ N Carolina, Lineberger Comprehens Canter Ctr, Chapel Hill, NC 27599 USA.
RP Kelada, SNP (reprint author), Univ N Carolina, Dept Genet, 120 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM samir_kelada@med.unc.edu
FU National Human Genome Research Institute, National Institutes of Health
   (NIH) [ZIA-HG200361]; U.S. Department of Energy, Office of Biological
   and Environmental Research; NIH [U01CA134240, U01CA105417, F32GM090667,
   K99ES021535, GM070683]; National Institutes of General Medical Sciences
   Centers of Excellence in Systems Biology program [GM076468]; Expression
   Localization Core Facility - National Institute of Neurological
   Disorders and Stroke Center grant [P30 NS045892]
FX We thank Drs. Francis S. Collins (National Institutes of Health, NIH)
   and David A. Schwartz (University of Colorado School of Medicine) for
   support and advice during the course of this project, Dr. Darla R.
   Miller (University of North Carolina, UNC) for providing research
   support that facilitated the mouse experiments conducted herein, John
   Didion (UNC) for his assistance with array probe SNP mapping, Kim Burns
   of the Marsico Lung Institute's Histology Core for assistance with mouse
   lung tissue sections, and Amanda Raimer for technical assistance with
   the pyro-sequencing assays. This work was supported in part by the
   intramural program of the National Human Genome Research Institute,
   National Institutes of Health (NIH) (ZIA-HG200361), the U.S. Department
   of Energy, Office of Biological and Environmental Research, and by NIH
   grants U01CA134240, U01CA105417, F32GM090667, K99ES021535, GM070683, an
   National Institutes of General Medical Sciences Centers of Excellence in
   Systems Biology program grant GM076468, and the Expression Localization
   Core Facility funded by National Institute of Neurological Disorders and
   Stroke Center grant P30 NS045892.
NR 53
TC 7
Z9 7
U1 0
U2 8
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 0016-6731
EI 1943-2631
J9 GENETICS
JI Genetics
PD OCT
PY 2014
VL 198
IS 2
BP 735
EP U376
DI 10.1534/genetics.114.168138
PG 18
WC Genetics & Heredity
SC Genetics & Heredity
GA AR9HX
UT WOS:000343885300031
PM 25114278
ER

PT J
AU Jensen, ET
   Daniels, JL
   Sturmer, T
   Robinson, WR
   Williams, CJ
   Moster, D
   Juliusson, PB
   Vejrup, K
   Magnus, P
   Longnecker, MP
AF Jensen, E. T.
   Daniels, J. L.
   Stuermer, T.
   Robinson, W. R.
   Williams, C. J.
   Moster, D.
   Juliusson, P. B.
   Vejrup, K.
   Magnus, P.
   Longnecker, M. P.
TI Maternal hormonal contraceptive use and offspring overweight or obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID GESTATIONAL DIABETES-MELLITUS; BIRTH-WEIGHT; ORAL-CONTRACEPTIVES;
   RISK-FACTORS; UNITED-STATES; EXPOSURE; PREGNANCY; METABOLISM; CHILDHOOD;
   CHILDREN
AB BACKGROUND/OBJECTIVES: Experiments in animal models have shown a positive association between in utero exposure to pharmacologic sex hormones and offspring obesity. The developmental effects of such hormones on human obesity are unknown.
   SUBJECTS/METHODS: Using data from a large, prospective pregnancy cohort study (n = 19 652), with linkage to a national prescription registry, we evaluated the association between use of hormonal contraceptives before and after conception (defined from dispensed prescription data and characterized by last date of use relative to conception, 12 to >4 months before (n = 3392), 4 to >1 months before (n = 2541), 1 to >0 months before (n = 2997) and 0-12 weeks after (n = 567)) in relation to offspring overweight or obesity at age 3 years.
   RESULTS: We observed a weak, inverse association between early pregnancy use of a combination oral contraceptive and offspring overweight or obesity at age 3 (adjusted odds ratio (OR): 0.75, 95% confidence interval (CI): 0.53, 1.08) and a positive, but imprecise, association with use of a progestin-only oral contraceptive in early pregnancy (adjusted OR: 1.26, 95% CI: 0.79, 2.02). In general, no association was observed between the use of a hormonal contraceptive before conception and offspring overweight or obesity. A sensitivity analysis comparing combination oral contraceptive users in early pregnancy to other unplanned pregnancies without hormonal contraceptive use further strengthened the inverse association (adjusted OR: 0.70, 95% CI: 0.48, 1.02). Other sensitivity analyses were conducted to evaluate the robustness of the associations observed given varying assumptions.
   CONCLUSIONS: Pharmacologic sex hormones in early pregnancy may be inversely or positively associated with offspring overweight or obesity at age 3, depending on the specific formulation used. The present study provides support for the potential for environmental sources of hormonally active agents to exert developmental effects.
C1 [Jensen, E. T.; Williams, C. J.; Longnecker, M. P.] Natl Inst Environm Hlth Sci, Dept Epidemiol, NIH, Res Triangle Pk, NC 27709 USA.
   [Jensen, E. T.; Daniels, J. L.; Stuermer, T.; Robinson, W. R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   [Moster, D.] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
   [Juliusson, P. B.] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Vejrup, K.; Magnus, P.] Natl Inst Publ Hlth, Div Epidemiol, Oslo, Norway.
RP Jensen, ET (reprint author), Natl Inst Environm Hlth Sci, Dept Epidemiol, NIH, POB 12233,Mail Drop A3-05, Res Triangle Pk, NC 27709 USA.
EM elizabeth.jensen@nih.gov
RI Jensen, Elizabeth/L-1466-2016; 
OI Longnecker, Matthew/0000-0001-6073-5322
FU Intramural Research Program of the National Institutes of Health,
   National Institute of Environmental Health Sciences [ES102985];
   University of North Carolina institutional training grant award for
   reproductive, perinatal, and pediatric epidemiology [T32HD052468];
   National Cancer Institute [1K01CA172717- 01]; Carolina Population Center
   [R24 HD050924]; Norwegian Ministry of Health [N01-ES-75558]; NIH/NIEHS;
   NIH/National Institute of Neurological Disorders and Stroke [1 UO1 NS
   047537-01]; Norwegian Research Council/FUGE [151918/S10]
FX We are grateful to all the participating families in Norway who took
   part in this ongoing cohort study. This work was supported in part by
   the Intramural Research Program of the National Institutes of Health,
   National Institute of Environmental Health Sciences (ES102985 to CJW),
   the University of North Carolina institutional training grant award for
   reproductive, perinatal, and pediatric epidemiology (grant T32HD052468
   to ETJ), the National Cancer Institute (1K01CA172717- 01 to WRR), and
   the Carolina Population Center (R24 HD050924 to WRR). The Norwegian
   Mother and Child Cohort Study is supported by the Norwegian Ministry of
   Health, contract N01-ES-75558 with the NIH/NIEHS, NIH/National Institute
   of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01) and the
   Norwegian Research Council/FUGE (grant 151918/S10).
NR 59
TC 3
Z9 3
U1 1
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2014
VL 38
IS 10
BP 1275
EP 1281
DI 10.1038/ijo.2014.114
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AR6CA
UT WOS:000343669200003
PM 24984751
ER

PT J
AU Boddu, R
   Yang, CZ
   O'Connor, AK
   Hendrickson, RC
   Boone, B
   Cui, XQ
   Garcia-Gonzalez, M
   Igarashi, P
   Onuchic, LF
   Germino, GG
   Guay-Woodford, LM
AF Boddu, Ravindra
   Yang, Chaozhe
   O'Connor, Amber K.
   Hendrickson, Robert Curtis
   Boone, Braden
   Cui, Xiangqin
   Garcia-Gonzalez, Miguel
   Igarashi, Peter
   Onuchic, Luiz F.
   Germino, Gregory G.
   Guay-Woodford, Lisa M.
TI Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE Autosomal recessive polycystic kidney disease; PKHD1; Alternative
   splicing; Exon splice enhancers
ID POLYCYSTIC KIDNEY-DISEASE; MOUSE MODEL; CLINICAL-EXPERIENCE; PRIMARY
   CILIA; PKHD1; ARPKD; BILIARY; RNA; IDENTIFICATION; PROTEIN
AB Autosomal recessive polycystic kidney disease (ARPKD) results from mutations in the human PKHD1 gene. Both this gene, and its mouse ortholog, Pkhd1, are primarily expressed in renal and biliary ductal structures. The mouse protein product, fibrocystin/polyductin complex (FPC), is a 445-kDa protein encoded by a 67-exon transcript that spans > 500 kb of genomic DNA. In the current study, we observed multiple alternatively spliced Pkhd1 transcripts that varied in size and exon composition in embryonic mouse kidney, liver, and placenta samples, as well as among adult mouse pancreas, brain, heart, lung, testes, liver, and kidney. Using reverse transcription PCR and RNASeq, we identified 22 novel Pkhd1 kidney transcripts with unique exon junctions. Various mechanisms of alternative splicing were observed, including exon skipping, use of alternate acceptor/donor splice sites, and inclusion of novel exons. Bioinformatic analyses identified, and exon-trapping minigene experiments validated, consensus binding sites for serine/arginine-rich proteins that modulate alternative splicing. Using site-directed mutagenesis, we examined the functional importance of selected splice enhancers. In addition, we demonstrated that many of the novel transcripts were polysome bound, thus likely translated. Finally, we determined that the human PKHD1 R760H missense variant alters a splice enhancer motif that disrupts exon splicing in vitro and is predicted to truncate the protein. Taken together, these data provide evidence of the complex transcriptional regulation of Pkhd1/PKHD1 and identified motifs that regulate its splicing. Our studies indicate that Pkhd1/PKHD1 transcription is modulated, in part by intragenic factors, suggesting that aberrant PKHD1 splicing represents an unappreciated pathogenic mechanism in ARPKD.
C1 [Boddu, Ravindra] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA.
   [Boddu, Ravindra; Yang, Chaozhe; Guay-Woodford, Lisa M.] Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA.
   [Yang, Chaozhe; O'Connor, Amber K.; Guay-Woodford, Lisa M.] Childrens Natl Med Ctr, Ctr Translat Sci, Washington, DC 20010 USA.
   [Boone, Braden] Hudson Alpha Inst, Huntsville, AL 35806 USA.
   [Hendrickson, Robert Curtis] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA.
   [Cui, Xiangqin] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA.
   [Garcia-Gonzalez, Miguel] Complexo Hosp Santiago de Compostela, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain.
   [Igarashi, Peter] Univ Texas Southwestern Sch Med, Dept Med, Dallas, TX 75235 USA.
   [Onuchic, Luiz F.] Univ Sao Paulo, Dept Med, BR-01246903 Sao Paulo, Brazil.
   [Germino, Gregory G.] Johns Hopkins Univ, Sch Med, Div Nephrol, Baltimore, MD 21205 USA.
   [Germino, Gregory G.] NIDDK, NIH, Bethesda, MD 20892 USA.
   [Guay-Woodford, Lisa M.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
RP Guay-Woodford, LM (reprint author), Childrens Natl Med Ctr, 6th Floor Main Hosp,Ctr 6,111 Michigan Ave NW, Washington, DC 20010 USA.
EM LGuaywoo@childrensnational.org
RI Onuchic, Luiz/H-1589-2012; 
OI O'Connor, Amber/0000-0002-1839-201X; Cui, Xiangqin/0000-0003-0621-9313;
   Igarashi, Peter/0000-0001-8698-1185
FU NIDDK and the NIDDK intramural program [R01DK51259, ZIA DK75042]; UAB
   Hepato-Renal Fibrocystic Disease Core Center [P30 DK074038]; Foundation
   for Research Support of the State of Sao Paulo [2004/02622-0]; NIH [UL1
   RR025777]
FX The authors acknowledge Drs. Mary Ann Accavitti, Feng Qian, Brad Yoder,
   and members of the Guay-Woodford laboratory for their helpful advice.
   This work was supported by the NIDDK and the NIDDK intramural program
   (R01DK51259 and ZIA DK75042) to G. G. G., the UAB Hepato-Renal
   Fibrocystic Disease Core Center (P30 DK074038) to LGW, from the
   Foundation for Research Support of the State of Sao Paulo (2004/02622-0
   to L.O.) and by the NIH-funded UAB Center for Clinical and Translational
   Science (UL1 RR025777). The authors have no conflicts to disclose.
NR 34
TC 5
Z9 5
U1 4
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD OCT
PY 2014
VL 92
IS 10
BP 1045
EP 1056
DI 10.1007/s00109-014-1185-7
PG 12
WC Genetics & Heredity; Medicine, Research & Experimental
SC Genetics & Heredity; Research & Experimental Medicine
GA AR8JI
UT WOS:000343821000005
PM 24984783
ER

PT J
AU Imanguli, MM
   Cowen, EW
   Rose, J
   Dhamala, S
   Swaim, W
   Lafond, S
   Yagi, B
   Gress, RE
   Pavletic, SZ
   Hakim, FT
AF Imanguli, M. M.
   Cowen, E. W.
   Rose, J.
   Dhamala, S.
   Swaim, W.
   Lafond, S.
   Yagi, B.
   Gress, R. E.
   Pavletic, S. Z.
   Hakim, F. T.
TI Comparative analysis of FoxP3(+) regulatory T cells in the target
   tissues and blood in chronic graft versus host disease
SO LEUKEMIA
LA English
DT Article
ID NONOBESE DIABETIC MICE; PERIPHERAL-BLOOD; CHRONIC GVHD; IN-VIVO;
   EXPRESSION; LESIONS; DIFFERENTIATION; INFLAMMATION; CYTOMEGALOVIRUS;
   DEMETHYLATION
AB Activation and migration of regulatory T cells (Treg) into tissue is critical in control of inflammation, but has not been examined extensively in chronic graft versus host disease (cGVHD). In parallel studies of tissues and blood, we determined that FoxP3(+) T cells increased in proportion to T effectors (Teff) in tissue infiltrates in oral and cutaneous lichenoid cGVHD. These FoxP3(+) cells expressed distinguishing phenotypic and functional markers of Treg (CD3(+), CD4(+), CD27(+), ICOS+ and CD39(+)), not found on FoxP3(-) Teff. Both Teff and FoxP3(+) Treg expressed T-bet and the chemokine receptor CXCR3, however, consistent with a common mechanism of chemokine-mediated migration into tissue. Furthermore, functional markers (ICOS and CD39) and chemokine receptors (CXCR3) were both present in a higher proportion of FoxP3(+) cells in tissues than in peripheral blood, consistent with recruitment and activation of Treg in cGVHD target tissues. Finally, the 'activated' CD45RA(-)FoxP3(hi) subset of Treg cells, which highly express functional markers, were found in comparable frequencies in cGVHD patients and normal controls, despite a significant deficit in naive 'resting' Treg. These findings are consistent with Treg capacity to upregulate functional markers and traffick into tissue in cGVHD.
C1 [Imanguli, M. M.; Rose, J.; Dhamala, S.; Lafond, S.; Yagi, B.; Gress, R. E.; Pavletic, S. Z.; Hakim, F. T.] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Imanguli, M. M.] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA.
   [Cowen, E. W.] NCI, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Swaim, W.] Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Bethesda, MD USA.
RP Hakim, FT (reprint author), NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, 10 Ctr Dr,CRC-3E-3330, Bethesda, MD 20892 USA.
EM hakimf@mail.nih.gov
FU Intramural Research Program of the Center for Cancer Research; National
   Cancer Institute; NIH
FX This research was supported by the Intramural Research Program of the
   Center for Cancer Research, National Cancer Institute, NIH. We would
   like to thank the cGVHD clinical team for their continuing support of
   cGVHD patient evaluation and care, and the staff of the Preclinical
   Development and Clinical Monitoring Core for supporting the collection
   and archiving of patient materials. Finally, we are grateful to all
   patients who volunteered for this study.
NR 47
TC 14
Z9 15
U1 1
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0887-6924
EI 1476-5551
J9 LEUKEMIA
JI Leukemia
PD OCT
PY 2014
VL 28
IS 10
BP 2016
EP 2027
DI 10.1038/leu.2014.92
PG 12
WC Oncology; Hematology
SC Oncology; Hematology
GA AR6CT
UT WOS:000343671400010
PM 24577531
ER

PT J
AU Moros, A
   Rodriguez, V
   Saborit-Villarroya, I
   Montraveta, A
   Balsas, P
   Sandy, P
   Martinez, A
   Wiestner, A
   Normant, E
   Campo, E
   Perez-Galan, P
   Colomer, D
   Roue, G
AF Moros, A.
   Rodriguez, V.
   Saborit-Villarroya, I.
   Montraveta, A.
   Balsas, P.
   Sandy, P.
   Martinez, A.
   Wiestner, A.
   Normant, E.
   Campo, E.
   Perez-Galan, P.
   Colomer, D.
   Roue, G.
TI Synergistic antitumor activity of lenalidomide with the BET bromodomain
   inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma
SO LEUKEMIA
LA English
DT Article
ID SINGLE-AGENT LENALIDOMIDE; PHASE-II; CEREBLON EXPRESSION;
   MULTIPLE-MYELOMA; CLINICAL-TRIAL; C-MYC; CANCER; IRF4; DIFFERENTIATION;
   PATHOGENESIS
AB Bortezomib therapy has shown promising clinical activity in mantle cell lymphoma (MCL), but the development of resistance to proteasome inhibition may limit its efficacy. To unravel the factors involved in the acquisition of bortezomib resistance in vivo, immunodeficient mice were engrafted with a set of MCL cell lines with different levels of sensitivity to the drug, followed by gene expression profiling of the tumors and functional validation of the identified gene signatures. We observed an increased tumorigenicity of bortezomib-resistant MCL cells in vivo, which was associated with plasmacytic differentiation features, like interferon regulatory factor 4 (IRF4) and Blimp-1 upregulation. Lenalidomide was particularly active in this subgroup of tumors, targeting IRF4 expression and plasmacytic differentiation program, thus overcoming bortezomib resistance. Moreover, repression of the IRF4 target gene MYC in bortezomib- resistant cells by gene knockdown or treatment with CPI203, a BET (bromodomain and extra terminal) bromodomain inhibitor, synergistically induced cell death when combined with lenalidomide. In mice, addition of CPI203 to lenalidomide therapy further decreased tumor burden, involving simultaneous MYC and IRF4 downregulation and apoptosis induction. Together, these results suggest that exacerbated IRF4/MYC signaling is associated to bortezomib resistance in MCL in vivo and warrant clinical evaluation of lenalidomide plus BET inhibitor combination in MCL cases refractory to proteasome inhibition.
C1 [Moros, A.; Rodriguez, V.; Saborit-Villarroya, I.; Montraveta, A.; Balsas, P.; Campo, E.; Perez-Galan, P.; Colomer, D.; Roue, G.] Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hematooncol Dept, Barcelona 08036, Spain.
   [Sandy, P.; Normant, E.] Constellat Pharmaceut Inc, Dept Pharmacol, Cambridge, MA USA.
   [Martinez, A.; Campo, E.; Colomer, D.] Hosp Clin Barcelona, Dept Pathol, Hematopathol Unit, Barcelona, Spain.
   [Martinez, A.] NHLBI, Hematol Branch, Nihon Univ, Bethesda, MD 20892 USA.
RP Roue, G (reprint author), Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hematooncol Dept, Rossello 153, Barcelona 08036, Spain.
EM groue@clinic.ub.es
RI Saborit, Ifigenia/E-9738-2016; Martinez, Antonio/D-8188-2012; Campo,
   elias/O-7192-2016; Roue, Gael/D-4759-2014; 
OI Saborit, Ifigenia/0000-0002-0928-3989; Martinez,
   Antonio/0000-0003-0790-9017; Campo, elias/0000-0001-9850-9793; Roue,
   Gael/0000-0003-0245-2257; COLOMER, DOLORS/0000-0001-7486-8484
FU Fondo de Investigacion Sanitaria [PI09/0060, PI12/01847]; Ministerio de
   Economia y Competitividad [SAF 09/9503, SAF 12/31242, SAF 11/29326];
   Redes Tematicas de Investigacion Cooperativa de Cancer from the
   Instituto de Salud Carlos III (ISCIII) [RD2006/20/014, RD12/0036/0004];
   Generalitat de Catalunya [2009SGR967]; IDIBAPS; Ministerio de Ciencia e
   Innovacion (FPI); Instituto de Salud Carlos III; Fondo de Investigacion
   Sanitaria; FEDER [PI11/00907]; European Regional Development Fund (ERDF)
   Una manera de hacer Europa'
FX Bortezomib, lenalidomide and CPI203 were kindly provided by
   Millenium-Takeda Oncology, Celgene Corporation and Constellation
   Pharmaceuticals, respectively. This work was supported by grants from
   Fondo de Investigacion Sanitaria (PI09/0060 and PI12/01847) (to G Roue),
   Ministerio de Economia y Competitividad (SAF 09/9503 and SAF 12/31242 to
   D Colomer; and SAF 11/29326 to P Perez-Galan), Redes Tematicas de
   Investigacion Cooperativa de Cancer from the Instituto de Salud Carlos
   III (ISCIII) (RD2006/20/014 and RD12/0036/0004) and Generalitat de
   Catalunya 2009SGR967 (to D Colomer), European Regional Development Fund
   (ERDF) Una manera de hacer Europa'. A Moros and A Montraveta were
   recipients of pre-doctoral fellowships from IDIBAPS and Ministerio de
   Ciencia e Innovacion (FPI), respectively. A Martinez was supported by
   Instituto de Salud Carlos III, Fondo de Investigacion Sanitaria and
   FEDER PI11/00907.
NR 40
TC 24
Z9 24
U1 2
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0887-6924
EI 1476-5551
J9 LEUKEMIA
JI Leukemia
PD OCT
PY 2014
VL 28
IS 10
BP 2049
EP 2059
DI 10.1038/leu.2014.106
PG 11
WC Oncology; Hematology
SC Oncology; Hematology
GA AR6CT
UT WOS:000343671400013
PM 24721791
ER

PT J
AU Guo, J
   Simmons, WK
   Herscovitch, P
   Martin, A
   Hall, KD
AF Guo, J.
   Simmons, W. K.
   Herscovitch, P.
   Martin, A.
   Hall, K. D.
TI Striatal dopamine D2-like receptor correlation patterns with human
   obesity and opportunistic eating behavior
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID HABIT FORMATION; DIETARY RESTRAINT; NUCLEUS-ACCUMBENS; BASAL GANGLIA;
   DISINHIBITION; BRAIN; PET; QUESTIONNAIRE; EXPOSURE; TRACERS
AB The obesity epidemic is believed to be driven by a food environment that promotes consumption of inexpensive, convenient, high-calorie, palatable foods. Individual differences in obesity susceptibility or resistance to weight loss may arise because of alterations in the neurocircuitry supporting food reward and eating habits. In particular, dopamine signaling in the ventromedial striatum is thought to encode food reward and motivation, whereas dopamine in the dorsal and lateral striatum orchestrates the development of eating habits. We measured striatal dopamine D2-like receptor binding potential (D2BP) using positron emission tomography with [F-18]fallypride in 43 human subjects with body mass indices (BMI) ranging from 18 to 45 kg m(-2). Opportunistic eating behavior and BMI were both positively associated with D2BP in the dorsal and lateral striatum, whereas BMI was negatively associated with D2BP in the ventromedial striatum. These results suggest that obese people have alterations in dopamine neurocircuitry that may increase their susceptibility to opportunistic overeating while at the same time making food intake less rewarding, less goal directed and more habitual. Whether or not the observed neurocircuitry alterations pre-existed or occurred as a result of obesity development, they may perpetuate obesity given the omnipresence of palatable foods and their associated cues.
C1 [Guo, J.; Hall, K. D.] NIDDK, Bethesda, MD 20892 USA.
   [Simmons, W. K.] Laureate Inst Brain Res, Tulsa, OK USA.
   [Simmons, W. K.] Univ Tulsa, Tulsa, OK 74104 USA.
   [Herscovitch, P.] NIH, Ctr Clin, PET Dept, Bethesda, MD 20892 USA.
   [Martin, A.] NIMH, Bethesda, MD 20892 USA.
RP Hall, KD (reprint author), NIDDK, 12A South Dr,Room 4007, Bethesda, MD 20892 USA.
EM kevinh@niddk.nih.gov
RI Simmons, William/K-8925-2015
OI Simmons, William/0000-0002-0399-9003
FU Intramural Research Program of the NIH; National Institute of Diabetes
   and Digestive and Kidney Diseases; National Institute of Mental Health;
   NIMH [K01MH096175-01]
FX We thank Kaiping Burrows, Valerie Darcy, Christine Hunter, John
   Ingeholm, Bernard V Miller, Monica Skarulis and Nora Volkow for their
   assistance with the study. This research was supported, in part, by the
   Intramural Research Program of the NIH, National Institute of Diabetes
   and Digestive and Kidney Diseases and National Institute of Mental
   Health. WKS' efforts were also partially supported by the NIMH
   K01MH096175-01 grant. The study was conducted under NIH Clinical Study
   Protocol 09-DK-0081 (ClinicalTrials. gov ID NCT00846040).
NR 30
TC 40
Z9 40
U1 1
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2014
VL 19
IS 10
BP 1078
EP 1084
DI 10.1038/mp.2014.102
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AR5ZN
UT WOS:000343661700007
PM 25199919
ER

PT J
AU Spies, E
   Muller, F
   Illerhaus, G
   Glatzel, M
   Trepel, M
AF Spies, E.
   Mueller, F.
   Illerhaus, G.
   Glatzel, M.
   Trepel, M.
TI Primary central nervous system lymphoma B-cell receptors recognize
   specific antigens in the brain
SO ONCOLOGY RESEARCH AND TREATMENT
LA English
DT Meeting Abstract
C1 [Spies, E.; Trepel, M.] Univ Klinikum Hamburg Eppendorf, Med Klin & Poliklin 2, AG Rezeptor Targeting, Hamburg, Germany.
   [Spies, E.; Trepel, M.] Univ Klinikum Hamburg Eppendorf, Med Klin & Poliklin 2, AG Rezeptor Targeting, Hamburg, Germany.
   [Mueller, F.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Illerhaus, G.] Klinikum Stuttgart, Onkol Zentrum, Stuttgart, Germany.
   [Glatzel, M.] Univ Klinikum Hamburg Eppendorf, Inst Neuropathol, Hamburg, Germany.
RI Glatzel, Markus/G-3356-2011
OI Glatzel, Markus/0000-0002-7720-8817
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2296-5270
EI 2296-5262
J9 ONCOL RES TREAT
JI Oncol. Res. Treat.
PD OCT
PY 2014
VL 37
SU 5
MA P242
BP 73
EP 73
PG 1
WC Oncology
SC Oncology
GA AR8HS
UT WOS:000343816900171
ER

PT J
AU Krause, C
   Herzberg, PY
   Pavletic, SZ
   Heussner, P
   Mumm, F
   Balsiger, C
   Hilgendorf, I
   Hemmati, P
   von Harsdorf, S
   Herr, W
   Holler, E
   Greinix, H
   Mitchell, SA
   Wolff, D
AF Krause, C.
   Herzberg, P. Y.
   Pavletic, S. Z.
   Heussner, P.
   Mumm, F.
   Balsiger, C.
   Hilgendorf, I
   Hemmati, P.
   von Harsdorf, S.
   Herr, W.
   Holler, E.
   Greinix, H.
   Mitchell, S. A.
   Wolff, D.
TI Comorbidity significantly impairs quality of life in patients after
   allogeneic hematopoietic stem cell transplantation - results from the
   prospective german multicenter validation trial
SO ONCOLOGY RESEARCH AND TREATMENT
LA English
DT Meeting Abstract
C1 [Krause, C.; Herzberg, P. Y.] Univ Bundeswehr Hamburg, Helmut Schmidt Univ, Dept Personal Psychol & Psychol Assessment, Hamburg, Germany.
   [Pavletic, S. Z.] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   [Heussner, P.; Mumm, F.; Balsiger, C.] Univ Munich, Klinikum Grosshadern, Dept Internal Med 3, D-80539 Munich, Germany.
   [Hilgendorf, I] Univ Rostock, Dept Hematol & Oncol, D-18055 Rostock, Germany.
   [Hemmati, P.] Charite, Dept Hematol & Oncol, D-13353 Berlin, Germany.
   [von Harsdorf, S.] Univ Ulm Klinikum, Dept Internal Med 3, Ulm, Germany.
   [Herr, W.; Holler, E.; Wolff, D.] Univ Klinikum Regensburg, Dept Internal Med 3, Regensburg, Germany.
   [Greinix, H.] Med Univ Wien, Dept Internal Med 1, Vienna, Austria.
   [Mitchell, S. A.] NCI, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2296-5270
EI 2296-5262
J9 ONCOL RES TREAT
JI Oncol. Res. Treat.
PD OCT
PY 2014
VL 37
SU 5
MA V587
BP 190
EP 190
PG 1
WC Oncology
SC Oncology
GA AR8HS
UT WOS:000343816900461
ER

PT J
AU Foell, J
   Andoh, J
   Bekrater-Bodmann, R
   Diers, M
   Fuchs, X
   Colloca, L
   Flor, H
AF Foell, Jens
   Andoh, Jamila
   Bekrater-Bodmann, Robin
   Diers, Martin
   Fuchs, Xaver
   Colloca, Luana
   Flor, Herta
TI Peripheral origin of phantom limb pain: Is it all resolved?
SO PAIN
LA English
DT Letter
ID AMPUTEES
C1 [Foell, Jens; Andoh, Jamila; Bekrater-Bodmann, Robin; Diers, Martin; Fuchs, Xaver; Flor, Herta] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, D-68159 Mannheim, Germany.
   [Foell, Jens] Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA.
   [Colloca, Luana] Natl Ctr Complementary & Alternat Med, Div Intramural Res, Bethesda, MD 20892 USA.
   [Colloca, Luana] NIMH, Bethesda, MD 20892 USA.
RP Foell, J (reprint author), Florida State Univ, Dept Psychol, 1107 W Call St, Tallahassee, FL 32306 USA.
EM jens.foell@gmx.de
RI Diers, Martin/M-9155-2013; 
OI Diers, Martin/0000-0002-3257-7299; Colloca, Luana/0000-0002-6503-4709;
   Flor, Herta/0000-0003-4809-5398
NR 10
TC 0
Z9 0
U1 1
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD OCT
PY 2014
VL 155
IS 10
BP 2205
EP 2206
DI 10.1016/j.pain.2014.08.028
PG 4
WC Anesthesiology; Clinical Neurology; Neurosciences
SC Anesthesiology; Neurosciences & Neurology
GA AR8NI
UT WOS:000343831300042
PM 25180014
ER

PT J
AU Kim, Y
   Rowland, J
   Jensen, R
AF Kim, Youngmee
   Rowland, Julia
   Jensen, Roxanne
TI Dyadic Relations of Depressive Symptoms with Quality of Life Vary by Age
   and Gender: Colorectal and Lung Cancer Survivors and Their Family
   Caregivers
SO PSYCHO-ONCOLOGY
LA English
DT Meeting Abstract
C1 [Kim, Youngmee] Univ Miami, Coral Gables, FL 33124 USA.
   [Rowland, Julia] NCI, Washington, DC USA.
   [Jensen, Roxanne] Georgetown Univ Med Ctr, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD OCT
PY 2014
VL 23
SU 3
SI SI
MA S11-0242
BP 35
EP 36
PG 2
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
   Biomedical
SC Oncology; Psychology; Biomedical Social Sciences
GA AS0YX
UT WOS:000344003700049
ER

PT J
AU Nakanishi, H
   Kurima, K
   Kawashima, Y
   Griffith, AJ
AF Nakanishi, Hiroshi
   Kurima, Kiyoto
   Kawashima, Yoshiyuki
   Griffith, Andrew J.
TI Mutations of TMC1 cause deafness by disrupting mechanoelectrical
   transduction
SO AURIS NASUS LARYNX
LA English
DT Article
DE DFNA36; DFNB7/B11; Hearing loss; Mechanoelectrical transduction; TMC1;
   TMC2
ID CELL MECHANOTRANSDUCER CHANNELS; SENSORINEURAL HEARING-LOSS; EAR
   HAIR-CELLS; INNER-EAR; EPIDERMODYSPLASIA-VERRUCIFORMIS; MECHANOSENSITIVE
   CHANNELS; MOUSE MODEL; LOSS DFNA36; EARLY-ONSET; GENE
AB Objective: Mutations of transmembrane channel-like 1 gene (TMC1) can cause dominant (DFNA36) or recessive (DFNB7/B11) deafness. In this article, we describe the characteristics of DFNA36 and DFNB7/ B11 deafness, the features of the Tmc1 mutant mouse strains, and recent advances in our understanding of TMC1 function.
   Methods: Publications related to TMC1, DFNA36, or DFNB7/B11 were identified through PubMed.
   Results: All affected DFNA36 subjects showed post-lingual, progressive, sensorineural hearing loss (HL), initially affecting high frequencies. In contrast, almost all affected DFNB7/B11 subjects demonstrated congenital or prelingual severe to profound sensorineural HL The mouse Tmc1 gene also has dominant and recessive mutant alleles that cause HL in mutant strains, including Beethoven, deafness, and Tmc1 knockout mice. These mutant mice have been instrumental for revealing that Tmc1 and its closely related paralog Tmc2 are expressed in cochlear and vestibular hair cells, and are required for hair cell mechanoelectrical transduction (MET). Recent studies suggest that TMC1 and TMC2 may be components of the long-sought hair cell MET channel.
   Conclusion: TMC1 mutations disrupt hair cell MET. Published by Elsevier Ireland Ltd.
C1 [Nakanishi, Hiroshi; Kurima, Kiyoto; Griffith, Andrew J.] NIDCD, Mol Biol & Genet Sect, NIH, Bethesda, MD 20892 USA.
   [Kawashima, Yoshiyuki] Tokyo Med & Dent Univ, Dept Otolaryngol, Bunkyo Ku, Tokyo 1138519, Japan.
RP Griffith, AJ (reprint author), NIDCD, Mol Biol & Genet Sect, NIH, 35A Convent Dr, Bethesda, MD 20892 USA.
EM griffita@nidcd.nih.gov
FU NIH [Z01-DC-000060-13]
FX We thank Dennis T. Drayna, Thomas B. Friedman and Jeffrey R. Holt for
   critical review of this manuscript. Work in the authors' laboratories
   was supported by NIH intramural research fund Z01-DC-000060-13 (A.J.G.).
NR 62
TC 4
Z9 5
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0385-8146
EI 1879-1476
J9 AURIS NASUS LARYNX
JI Auris Nasus Larynx
PD OCT
PY 2014
VL 41
IS 5
BP 399
EP 408
DI 10.1016/j.anl.2014.04.001
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA AR1SB
UT WOS:000343363800001
PM 24933710
ER

PT J
AU Zhang, JW
   Jones, CP
   Ferre-D'Amare, AR
AF Zhang, Jinwei
   Jones, Christopher P.
   Ferre-D'Amare, Adrian R.
TI Global analysis of riboswitches by small-angle X-ray scattering and
   calorimetry
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
LA English
DT Review
DE Small-angle X-ray scattering; Isothermal titration calorimety;
   Enthalpy-entropy compensation; Conformational selection; Induced fit
ID ENTHALPY-ENTROPY COMPENSATION; ISOTHERMAL TITRATION CALORIMETRY; GROUP-I
   RIBOZYME; LIGAND-BINDING; TRANSFER-RNA; BACILLUS-SUBTILIS; HAIRPIN
   RIBOZYME; GENE-EXPRESSION; SMALL MOLECULES; STRUCTURAL INSIGHTS
AB Riboswitches are phylogenetically widespread non-coding mRNA domains that directly bind cellular metabolites and regulate transcription, translation, RNA stability or splicing via alternative RNA structures modulated by ligand binding. The details of ligand recognition by many riboswitches have been elucidated using X-ray crystallography and NMR. However, the global dynamics of riboswitch-ligand interactions and their thermodynamic driving forces are less understood. By compiling the work of many laboratories investigating riboswitches using small-angle X-ray scattering (SAXS) and isothermal titration calorimetry (ITC), we uncover general trends and common themes. There is a pressing need for community-wide consensus experimental conditions to allow results of riboswitch studies to be compared rigorously. Nonetheless, our meta-analysis reveals considerable diversity in the extent to which ligand binding reorganizes global riboswitch structures. It also demonstrates a wide spectrum of enthalpy-entropy compensation regimes across riboswitches that bind a diverse set of ligands, giving rise to a relatively narrow range of physiologically relevant free energies and ligand affinities. From the strongly entropy-driven binding of glycine to the predominantly enthalpy-driven binding of c-di-GMP to their respective riboswitches, these distinct thermodynamic signatures reflect the versatile strategies employed by RNA to adapt to the chemical natures of diverse ligands. Riboswitches have evolved to use a combination of long-range tertiary interactions, conformational selection, and induced fit to work with distinct ligand structure, charge, and salvation properties. This article is part of a Special Issue entitled: Riboswitches. Published by Elsevier B.V.
C1 [Zhang, Jinwei; Jones, Christopher P.; Ferre-D'Amare, Adrian R.] NHLBI, Bethesda, MD 20892 USA.
RP Ferre-D'Amare, AR (reprint author), NHLBI, 50 South Dr,MSC 8012, Bethesda, MD 20892 USA.
EM adrian.ferre@nih.gov
FU National Heart, Lung and Blood Institute, NIH
FX We thank N. Baird and M. Lau for comments on the manuscript; N. Baird
   for providing SAXS-derived riboswitch envelopes for comparison; and Y-X
   Wang, X-Y Fang, X. Zuo and G. Piszczek for SAXS and ITC experimental
   support. This work was supported in part by the intramural program of
   the National Heart, Lung and Blood Institute, NIH.
NR 89
TC 14
Z9 14
U1 2
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-9399
EI 0006-3002
J9 BBA-GENE REGUL MECH
JI Biochim. Biophys. Acta-Gene Regul. Mech.
PD OCT
PY 2014
VL 1839
IS 10
SI SI
BP 1020
EP 1029
DI 10.1016/j.bbagrm.2014.04.014
PG 10
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AR5JH
UT WOS:000343620700015
PM 24769285
ER

PT J
AU Simeon-Dubach, D
   Henderson, MK
AF Simeon-Dubach, Daniel
   Henderson, Marianne K.
TI Sustainability in Biobanking
SO BIOPRESERVATION AND BIOBANKING
LA English
DT Editorial Material
ID SAMPLE PREANALYTICAL CODE; INCIDENTAL FINDINGS; GENOMIC BIOBANKS;
   RESEARCH IMPACT; BIOSPECIMEN USE; CANCER-RESEARCH; FUTURE; RETURN;
   REPOSITORY; MATTERS
C1 [Simeon-Dubach, Daniel] Medserv Biobanking Consulting & Serv, CH-6318 Walchwil, Switzerland.
   [Henderson, Marianne K.] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
RP Henderson, MK (reprint author), NCI, Off Div Operat & Anal, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
EM biobanking@medservice.ch; hendersm@mail.nih.gov
RI Simeon-Dubach, Daniel/J-8276-2016
NR 37
TC 11
Z9 11
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1947-5535
EI 1947-5543
J9 BIOPRESERV BIOBANK
JI Biopreserv. Biobank.
PD OCT 1
PY 2014
VL 12
IS 5
BP 287
EP 291
DI 10.1089/bio.2014.1251
PG 5
WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology
SC Cell Biology; Chemistry; Medical Laboratory Technology
GA AR2LV
UT WOS:000343419500001
PM 25314050
ER

PT J
AU Bassim, CW
   Fassil, H
   Dobbin, M
   Steinberg, SM
   Baird, K
   Cole, K
   Joe, G
   Comis, LE
   Mitchell, SA
   Grkovic, L
   Edwards, D
   Mays, JW
   Cowen, EW
   Pulanic, D
   Williams, KM
   Gress, RE
   Pavletic, SZ
AF Bassim, C. W.
   Fassil, H.
   Dobbin, M.
   Steinberg, S. M.
   Baird, K.
   Cole, K.
   Joe, G.
   Comis, L. E.
   Mitchell, S. A.
   Grkovic, L.
   Edwards, D.
   Mays, J. W.
   Cowen, E. W.
   Pulanic, D.
   Williams, K. M.
   Gress, R. E.
   Pavletic, S. Z.
TI Malnutrition in patients with chronic GVHD
SO BONE MARROW TRANSPLANTATION
LA English
DT Article
ID VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; WORKING
   GROUP-REPORT; MARROW-TRANSPLANTATION; CLINICAL-TRIALS; CANCER; CRITERIA;
   SURVIVORS; WEIGHT; SCALE
AB Malnutrition is a known complication of chronic GVHD (cGVHD), but has not been well described in the context of organ-specific manifestations and the recent National Institutes of Health (NIH) criteria. Here, 210 cGVHD patients were analyzed, in a cross-sectional study design, for demographics, transplant-related history, clinical assessments, symptoms, function, quality-of-life, laboratory values and survival in order to determine their associations with nutritional status. Most patients had long-standing, moderate or severe cGVHD and had failed many lines of therapy. Twenty-nine percent (60/210) of subjects were malnourished, using the subjective Patient-Generated Subjective Global Assessment (PG-SGA) questionnaire and evaluation. No demographic or transplant characteristics were associated with malnutrition; cGVHD of the lungs, gastrointestinal (GI) tract and mouth, NIH global score, cGVHD symptoms, worse functioning, low albumin, poorer survival and low BMI were associated with malnutrition. A predictive model was developed from all variables of significance: cGVHD of the lungs, GI tract, mouth and BMI accurately predicted 84.2% of malnourished patients as well as 87.2% of well-nourished patients. The PG-SGA questionnaire may be a useful tool in diagnosing nutritional deficits in cGVHD patients undergoing one-time evaluations. Longitudinal prospective studies should assess the utility of nutritional support interventions in cGVHD.
C1 [Bassim, C. W.; Edwards, D.; Mays, J. W.] Natl Inst Dent & Craniofacial Res, Clin Res Ctr, NIH, Bethesda, MD 20892 USA.
   [Fassil, H.; Cole, K.; Grkovic, L.; Pulanic, D.; Williams, K. M.; Gress, R. E.; Pavletic, S. Z.] NCI, Expt Transplantat & Immunol Branch, NIH, Bethesda, MD 20892 USA.
   [Dobbin, M.] NIH, Dept Nutr, Bethesda, MD 20892 USA.
   [Steinberg, S. M.] NCI, Ctr Canc Res, Off Clin Director, Biostat & Data Management Sect,NIH, Bethesda, MD 20892 USA.
   [Baird, K.] NCI, Pediatr Oncol Branch, NIH, Bethesda, MD 20892 USA.
   [Joe, G.; Comis, L. E.] NIH, Dept Rehabil Med, Bethesda, MD 20892 USA.
   [Mitchell, S. A.] NCI, Outcomes Res Branch, NIH, Bethesda, MD 20892 USA.
   [Grkovic, L.; Pulanic, D.] Clin Hosp Ctr Zagreb, Dept Internal Med, Div Hematol, Zagreb, Croatia.
   [Cowen, E. W.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA.
RP Bassim, CW (reprint author), Natl Inst Dent & Craniofacial Res, Clin Res Ctr, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM bassimc@mail.nih.gov
FU intramural programs of the National Cancer Institute, Center for Cancer
   Research; National Institute of Dental and Craniofacial Research;
   intramural programs of the National Institutes of Health
FX This study was funded by the intramural programs of the National Cancer
   Institute, Center for Cancer Research and the National Institute of
   Dental and Craniofacial Research, as well as by the other intramural
   programs of the National Institutes of Health.
NR 31
TC 6
Z9 6
U1 1
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0268-3369
EI 1476-5365
J9 BONE MARROW TRANSPL
JI Bone Marrow Transplant.
PD OCT
PY 2014
VL 49
IS 10
BP 1300
EP 1306
DI 10.1038/bmt.2014.145
PG 7
WC Biophysics; Oncology; Hematology; Immunology; Transplantation
SC Biophysics; Oncology; Hematology; Immunology; Transplantation
GA AR5ZC
UT WOS:000343660300009
PM 25029231
ER

PT J
AU Yonekawa, T
   Malicdan, MCV
   Cho, A
   Hayashi, YK
   Nonaka, I
   Mine, T
   Yamamoto, T
   Nishino, I
   Noguchi, S
AF Yonekawa, Takahiro
   Malicdan, May Christine V.
   Cho, Anna
   Hayashi, Yukiko K.
   Nonaka, Ikuya
   Mine, Toshiki
   Yamamoto, Takeshi
   Nishino, Ichizo
   Noguchi, Satoru
TI Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE
   myopathy model mice
SO BRAIN
LA English
DT Article
DE amyloid inclusion; distal myopathy with rimmed vacuoles
   (DMRV)/hereditary inclusion body myopathy (hIBM); GNE myopathy;
   hyposialylation; sialyllactose
ID INCLUSION-BODY MYOPATHY; RIMMED VACUOLES; SIALIC-ACID; DISTAL MYOPATHY;
   MOUSE MODEL; N-ACETYLMANNOSAMINE; MUTATION; SIALYLATION; PROTEINURIA;
   AUTOPHAGY
AB Patients with GNE myopathy, a progressive and debilitating disease caused by a genetic defect in sialic acid biosynthesis, rely on supportive care and eventually become wheelchair-bound. To elucidate whether GNE myopathy is treatable at a progressive stage of the disease, we examined the efficacy of sialic acid supplementation on symptomatic old GNE myopathy mice that have ongoing, active muscle degeneration. We examined the therapeutic effect of a less metabolized sialic acid compound (6'-sialyllactose) or free sialic acid (N-acetylneuraminic acid) by oral, continuous administration to 50-week-old GNE myopathy mice for 30 weeks. To evaluate effects on their motor performance in living mice, spontaneous locomotion activity on a running wheel was measured chronologically at 50, 65, 72 and 80 weeks of age. The size, force production, and pathology of isolated gastrocnemius muscle were analysed at the end point. Sialic acid level in skeletal muscle was also measured. Spontaneous locomotion activity was recovered in 6'-sialyllactose-treated mice, while NeuAc-treated mice slowed the disease progression. Treatment with 6'-sialyllactose led to marked restoration of hyposialylation in muscle and consequently to robust improvement in the muscle size, contractile parameters, and pathology as compared to NeuAc. This is due to the fact that 6'-sialyllactose is longer working as it is further metabolized to free sialic acid after initial absorption. 6'-sialyllactose ameliorated muscle atrophy and degeneration in symptomatic GNE myopathy mice. Our results provide evidence that GNE myopathy can be treated even at a progressive stage and 6'-sialyllactose has more remarkable advantage than free sialic acid, providing a conceptual proof for clinical use in patients.
C1 [Yonekawa, Takahiro; Cho, Anna; Hayashi, Yukiko K.; Nonaka, Ikuya; Nishino, Ichizo; Noguchi, Satoru] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neuromuscular Res, Kodaira, Tokyo 1878502, Japan.
   [Yonekawa, Takahiro; Nishino, Ichizo] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Educ, Kofu, Yamanashi, Japan.
   [Malicdan, May Christine V.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Hayashi, Yukiko K.; Nishino, Ichizo; Noguchi, Satoru] Natl Ctr Neurol & Psychiat, Dept Clin Dev, Translat Med Ctr, Kodaira, Tokyo 1878502, Japan.
   [Hayashi, Yukiko K.] Tokyo Med Univ, Dept Neurophysiol, Tokyo 1608402, Japan.
   [Mine, Toshiki; Yamamoto, Takeshi] Japan Tabacco Inc, Glycotechnol Business Unit, Shizuoka, Japan.
RP Noguchi, S (reprint author), Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neuromuscular Res, 4-1-1 Ogawa Higashicho, Kodaira, Tokyo 1878502, Japan.
EM noguchi@ncnp.go.jp
OI Nishino, Ichizo/0000-0001-9452-112X
FU Intramural Research Grant for Neurological and Psychiatric Disorders of
   NCNP [25-5]; Comprehensive Research on Disability Health and Welfare
   from the Ministry of Health, Labour and Welfare; JSPS KAKENHI [23390236]
FX This study was partially supported by Intramural Research Grant (25-5)
   for Neurological and Psychiatric Disorders of NCNP, by Comprehensive
   Research on Disability Health and Welfare from the Ministry of Health,
   Labour and Welfare, and by JSPS KAKENHI (23390236).
NR 19
TC 12
Z9 12
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD OCT
PY 2014
VL 137
BP 2670
EP 2679
DI 10.1093/brain/awu210
PN 10
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AR2MG
UT WOS:000343420900014
PM 25062695
ER

PT J
AU Guo, H
   Bassig, BA
   Lan, Q
   Zhu, Y
   Zhang, YW
   Holford, TR
   Leaderer, B
   Boyle, P
   Qin, Q
   Zhu, CR
   Li, N
   Rothman, N
   Zheng, TZ
AF Guo, Huan
   Bassig, Bryan A.
   Lan, Qing
   Zhu, Yong
   Zhang, Yawei
   Holford, Theodore R.
   Leaderer, Brian
   Boyle, Peter
   Qin, Qin
   Zhu, Cairong
   Li, Ni
   Rothman, Nathaniel
   Zheng, Tongzhang
TI Polymorphisms in DNA repair genes, hair dye use, and the risk of
   non-Hodgkin lymphoma
SO CANCER CAUSES & CONTROL
LA English
DT Article
DE Non-Hodgkin lymphoma; Hair dye use; DNA repair; Genetic polymorphism;
   Interaction
ID OCCUPATIONAL SOLVENT EXPOSURE; WERNER SYNDROME PROTEIN; PERSONAL USE;
   ASSOCIATION; EPIDEMIOLOGY; CONNECTICUT; EXPRESSION; ETIOLOGY; SUBTYPES;
   CANCER
AB Genetic polymorphisms in DNA repair genes and hair dye use may both have a role in the development of non-Hodgkin lymphoma (NHL). We aimed to examine the interaction between variants in DNA repair genes and hair dye use with risk of NHL in a population-based case-control study of Connecticut women.
   We examined 24 single nucleotide polymorphisms in 16 DNA repair genes among 518 NHL cases and 597 controls and evaluated the associations between hair dye use and risk of overall NHL and common NHL subtypes, stratified by genotype, using unconditional logistic regression.
   Women who used hair dye before 1980 had a significantly increased risk of NHL, particularly for the follicular lymphoma (FL) subtype, but not for diffuse large B-cell lymphoma. The following genotypes in combination with hair dye use before 1980 were associated with FL risk: BRCA2 rs144848 AC+CC [odds ratio (OR) (95 % confidence interval (CI)) 3.28(1.27-8.50)], WRN rs1346044 TT [OR(95 % CI) 2.70(1.30-5.65)], XRCC3 rs861539 CT+TT [OR(95 % CI) 2.76(1.32-5.77)], XRCC4 rs1805377 GG [OR(95 % CI) 2.07(1.10-3.90)] and rs1056503 TT [OR(95 % CI) 2.17(1.16-4.07)], ERCC1 rs3212961 CC [OR(95 % CI) 1.93(1.00-3.72)], RAD23B rs1805329 CC [OR(95 % CI) 2.28(1.12-4.64)], and MGMT rs12917 CC, rs2308321 AA, and rs2308327 AA genotypes [OR(95 % CI) 1.96(1.06-3.63), 2.02(1.09-3.75), and 2.23(1.16-4.29), respectively]. In addition, a significant interaction with risk of overall NHL was observed between WRN rs1346044 and hair dye use before 1980 (p (interaction) = 0.032).
   Our results indicated that genetic variation in DNA repair genes modifies susceptibility to NHL in relation to hair dye use, particularly for the FL subtype and in women who began using hair dye before 1980. Further studies are needed to confirm these observations.
C1 [Guo, Huan; Bassig, Bryan A.; Zhu, Yong; Zhang, Yawei; Holford, Theodore R.; Leaderer, Brian; Qin, Qin; Zheng, Tongzhang] Yale Univ, Sch Publ Hlth, Div Environm Hlth Sci, New Haven, CT 06510 USA.
   [Guo, Huan] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Guo, Huan] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Bassig, Bryan A.; Lan, Qing; Rothman, Nathaniel] NCI, NIH, DHHS, Bethesda, MD 20892 USA.
   [Boyle, Peter] Int Prevent Res Inst, F-69006 Lyon, France.
   [Zhu, Cairong] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China.
   [Li, Ni] Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100021, Peoples R China.
RP Zheng, TZ (reprint author), Yale Univ, Sch Publ Hlth, Div Environm Hlth Sci, New Haven, CT 06510 USA.
EM tongzhang.zheng@yale.edu
RI Boyle, Peter/A-4380-2014
OI Boyle, Peter/0000-0001-6251-0610
FU National Cancer Institute [CA62006]; National Institutes of Health
   [D43TW 008323, D43TW 007864-01]
FX This work was partly supported by National Cancer Institute grant
   CA62006 (Connecticut Women's NHL Study, Yale University) and by Fogarty
   training grants D43TW 008323 and D43TW 007864-01 from the National
   Institutes of Health (T. Zheng). Certain data used in this study were
   obtained from the Connecticut Tumor Registry located in the Connecticut
   Department of Public Health. The author(s) assume(s) full responsibility
   for analyses and interpretation of these data. The cooperation of 28
   Connecticut hospitals, including Charlotte Hungerford Hospital,
   Bridgeport Hospital, Danbury Hospital, Hartford Hospital, Middlesex
   Hospital, New Britain General Hospital, Bradley Memorial Hospital,
   Yale/New Haven Hospital, St. Francis Hospital and Medical Center, St.
   Mary's Hospital, Hospital of St. Raphael, St. Vincent's Medical Center,
   Stamford Hospital, William W. Backus Hospital, Windham Hospital, Eastern
   Connecticut Health Network, Griffin Hospital, Bristol Hospital, Johnson
   Memorial Hospital, Day Kimball Hospital, Greenwich Hospital, Lawrence
   and Memorial Hospital, Milford Hospital, New Milford Hospital, Norwalk
   Hospital, MidState Medical Center, John Dempsey Hospital, and Waterbury
   Hospital, in allowing patient access, is gratefully acknowledged.
NR 33
TC 2
Z9 2
U1 2
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-5243
EI 1573-7225
J9 CANCER CAUSE CONTROL
JI Cancer Causes Control
PD OCT
PY 2014
VL 25
IS 10
BP 1261
EP 1270
DI 10.1007/s10552-014-0423-1
PG 10
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA AR6UP
UT WOS:000343718900003
PM 25178586
ER

PT J
AU Tomasi, D
   Wang, RL
   Wang, GJ
   Volkow, ND
AF Tomasi, Dardo
   Wang, Ruiliang
   Wang, Gene-Jack
   Volkow, Nora D.
TI Functional Connectivity and Brain Activation: A Synergistic Approach
SO CEREBRAL CORTEX
LA English
DT Article
DE attention; FCD; fMRI; hub; performance
ID LOW-FREQUENCY FLUCTUATION; DEFAULT MODE NETWORK; RESTING-STATE FMRI;
   VISUAL-ATTENTION; WORKING-MEMORY; AREA V2; 4 TESLA; TASK; MOTION; MRI
AB Traditional functional magnetic resonance imaging (fMRI) studies exploit endogenous brain activity for mapping brain activation during "periodic" cognitive/emotional challenges or brain functional connectivity during the "resting state". Previous studies demonstrated that these approaches provide a limited view of brain function which can be complemented by each other. We hypothesized that graph theory functional connectivity density (FCD) mapping would demonstrate regional FCD decreases between resting-state scan and a continuous "task-state" scan. Forty-five healthy volunteers underwent functional connectivity MRI during resting-state as well as a continuous visual attention task, and standard fMRI with a blocked version of the visual attention task. High-resolution data-driven FCD mapping was used to measure task-related connectivity changes without a priori hypotheses. Results demonstrate that task performance was associated with FCD decreases in brain regions weakly activated/deactivated by the task. Furthermore, a pronounced negative correlation between blood oxygen level-dependent-fMRI activation and task-related FCD decreases emerged across brain regions that also suggest the disconnection of task-irrelevant networks during task performance. The correlation between improved accuracy and stronger FCD decreases further suggests the disconnection of task-irrelevant networks during task performance. Functional connectivity can potentiate traditional fMRI studies and offer a more complete picture of brain function.
C1 [Tomasi, Dardo; Volkow, Nora D.] NIAAA, Bethesda, MD USA.
   [Wang, Ruiliang; Wang, Gene-Jack] Brookhaven Natl Lab, Lab Neuroimaging LNI NIAAA, Dept Biosci, Upton, NY 11973 USA.
   [Wang, Gene-Jack] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA.
   [Volkow, Nora D.] NIDA, Bethesda, MD 20892 USA.
RP Tomasi, D (reprint author), Brookhaven Natl Lab, Lab Neuroimaging LNI NIAAA, Dept Biosci, Bldg 490,30 Bell Ave, Upton, NY 11973 USA.
EM tomasi@bnl.gov
RI Tomasi, Dardo/J-2127-2015
FU National Institutes of Alcohol Abuse and Alcoholism [2RO1AA09481]
FX This work was accomplished with support from the National Institutes of
   Alcohol Abuse and Alcoholism (2RO1AA09481).
NR 62
TC 18
Z9 18
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD OCT
PY 2014
VL 24
IS 10
BP 2619
EP 2629
DI 10.1093/cercor/bht119
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AR2IT
UT WOS:000343408200009
PM 23645721
ER

PT J
AU Villemure, C
   Ceko, M
   Cotton, VA
   Bushnell, MC
AF Villemure, Chantal
   Ceko, Marta
   Cotton, Valerie A.
   Bushnell, M. Catherine
TI Insular Cortex Mediates Increased Pain Tolerance in Yoga Practitioners
SO CEREBRAL CORTEX
LA English
DT Article
DE DTI; insula; pain tolerance; VBM; yoga practice
ID AUTOMATED 3-D EXTRACTION; VOXEL-BASED MORPHOMETRY; WHITE-MATTER
   INTEGRITY; MEDITATION PRACTITIONERS; MINDFULNESS PRACTICE; CORTICAL
   THICKNESS; MRI DATA; BRAIN; CONNECTIVITY; REGISTRATION
AB Yoga, an increasingly popular discipline among Westerners, is frequently used to improve painful conditions. We investigated possible neuroanatomical underpinnings of the beneficial effects of yoga using sensory testing and magnetic resonance imaging techniques. North American yogis tolerated pain more than twice as long as individually matched controls and had more gray matter (GM) in multiple brain regions. Across subjects, insular GM uniquely correlated with pain tolerance. Insular GM volume in yogis positively correlated with yoga experience, suggesting a causal relationship between yoga and insular size. Yogis also had increased left intrainsular white matter integrity, consistent with a strengthened insular integration of nociceptive input and parasympathetic autonomic regulation. Yogis, as opposed to controls, used cognitive strategies involving parasympathetic activation and interoceptive awareness to tolerate pain, which could have led to use-dependent hypertrophy of insular cortex. Together, these findings suggest that regular and long-term yoga practice improves pain tolerance in typical North Americans by teaching different ways to deal with sensory inputs and the potential emotional reactions attached to those inputs leading to a change in insular brain anatomy and connectivity.
C1 [Villemure, Chantal; Ceko, Marta; Cotton, Valerie A.; Bushnell, M. Catherine] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
   [Bushnell, M. Catherine] McGill Univ, Fac Dent, Montreal, PQ, Canada.
   [Bushnell, M. Catherine] McGill Univ, Dept Anesthesiol, Montreal, PQ, Canada.
   [Bushnell, M. Catherine] McGill Univ, Dept Neurol & Neurosurg, Fac Med, Montreal, PQ, Canada.
   [Ceko, Marta; Bushnell, M. Catherine] McGill Univ, Integrated Program Neurosci, Montreal, PQ, Canada.
   [Villemure, Chantal; Ceko, Marta; Bushnell, M. Catherine] NIH, NCCAM, Bethesda, MD 20892 USA.
RP Ceko, M (reprint author), NIH, NCCAM, 10 Ctr Dr Rm 4-1730, Bethesda, MD 20892 USA.
EM marta.ceko@nih.gov
FU Intramural Research Program of the NIH; National Center for
   Complementary and Alternative Medicine
FX This research was supported in part by the Intramural Research Program
   of the NIH and National Center for Complementary and Alternative
   Medicine.
NR 62
TC 20
Z9 20
U1 3
U2 26
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD OCT
PY 2014
VL 24
IS 10
BP 2732
EP 2740
DI 10.1093/cercor/bht124
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA AR2IT
UT WOS:000343408200018
PM 23696275
ER

PT J
AU Conner, CR
   Chen, G
   Pieters, TA
   Tandon, N
AF Conner, Christopher R.
   Chen, Gang
   Pieters, Thomas A.
   Tandon, Nitin
TI Category Specific Spatial Dissociations of Parallel Processes Underlying
   Visual Naming
SO CEREBRAL CORTEX
LA English
DT Article
DE electrocorticography; fMRI; functional mapping; language; naming
ID INFERIOR FRONTAL GYRUS; HUMAN BRAIN; INTERSUBJECT VARIABILITY;
   PREFRONTAL CORTEX; COGNITIVE CONTROL; SPEECH PRODUCTION; CORTICAL
   REGIONS; BROCAS AREA; BOLD-FMRI; LANGUAGE
AB The constituent elements and dynamics of the networks responsible for word production are a central issue to understanding human language. Of particular interest is their dependency on lexical category, particularly the possible segregation of nouns and verbs into separate processing streams. We applied a novel mixed-effects, multilevel analysis to electrocorticographic data collected from 19 patients (1942 electrodes) to examine the activity of broadly disseminated cortical networks during the retrieval of distinct lexical categories. This approach was designed to overcome the issues of sparse sampling and individual variability inherent to invasive electrophysiology. Both noun and verb generation evoked overlapping, yet distinct nonhierarchical processes favoring ventral and dorsal visual streams, respectively. Notable differences in activity patterns were noted in Broca's area and superior lateral temporo-occipital regions (verb > noun) and in parahippocampal and fusiform cortices (noun > verb). Comparisons with functional magnetic resonance imaging (fMRI) results yielded a strong correlation of blood oxygen level-dependent signal and gamma power and an independent estimate of group size needed for fMRI studies of cognition. Our findings imply parallel, lexical category-specific processes and reconcile discrepancies between lesional and functional imaging studies.
C1 [Conner, Christopher R.; Pieters, Thomas A.; Tandon, Nitin] Univ Texas Med Sch Houston, Vivian L Smith Dept Neurosurg, Houston, TX 77030 USA.
   [Chen, Gang] NIMH, Sci & Stat Comp Core, NIH, US Dept HHS, Bethesda, MD 20892 USA.
   [Tandon, Nitin] Mem Hermann Hosp, Texas Med Ctr, Houston, TX USA.
RP Tandon, N (reprint author), Univ Texas Med Sch Houston, 6431 Fannin St Suite G-500, Houston, TX 77030 USA.
EM nitin.tandon@uth.tmc.edu
OI Conner, Christopher R/0000-0003-0176-9025; Tandon,
   Nitin/0000-0002-2752-2365
FU NIH Center for Clinical and Translational Sciences [KL2 RR0224149];
   Vivian Smith Foundation for Neurologic Research; Keck Center of the Gulf
   Coast Consortia, on the Training in Theoretical and Computational
   Neuroscience, National Institute of Biomedical Imaging and
   Bioengineering [T32EB006350]
FX This work was supported by NIH Center for Clinical and Translational
   Sciences (KL2 RR0224149 to N.T.), the Vivian Smith Foundation for
   Neurologic Research, and the Keck Center of the Gulf Coast Consortia, on
   the Training in Theoretical and Computational Neuroscience, National
   Institute of Biomedical Imaging and Bioengineering (T32EB006350 to
   C.R.C.).
NR 54
TC 8
Z9 8
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD OCT
PY 2014
VL 24
IS 10
BP 2741
EP 2750
DI 10.1093/cercor/bht130
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AR2IT
UT WOS:000343408200019
PM 23696279
ER

PT J
AU Waidyanatha, S
   Gaudette, NF
   Hong, Y
   Fennell, TR
AF Waidyanatha, Suramya
   Gaudette, Norman F.
   Hong, Yan
   Fennell, Timothy R.
TI Formation of Epichlorohydrin, a Known Rodent Carcinogen, Following Oral
   Administration of 1,3-Dichloro-2-propanol in Rats
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID HEPATOCYTE CULTURES; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE; GLUTATHIONE
   DEPLETION; EPOXIDE HYDROLASES; SOS CHROMOTEST; MUTAGENICITY; TOXICITY;
   METABOLISM; DICHLOROPROPANOL; DISPOSITION
AB The observed toxicity and carcinogenicity of 1,3-dichloro-2-propanol (DCP) in rodents is thought to be due to the formation of reactive metabolites, epichlorohydrin (ECH) and dichloroacetone (DCA). However, there is no direct evidence for the formation of these metabolites from exposure to DCP in rodents due to the challenges of measuring these reactive intermediates directly in vivo. The objective of this work was to investigate the metabolism of DCP to ECH and DCA in vivo by first developing a sensitive analytical method in a suitable biological matrix and analyzing samples from rats administered DCP. DCA reacted rapidly in vitro in rat blood, plasma, and liver homogenate, precluding its detection. Because ECH rapidly disappeared in liver homogenate, but was relatively long-lived in plasma and blood in vitro, blood was selected for analysis of this metabolite. Following a single oral dose of 50 mg/kg DCP in male or female Harlan Sprague Dawley rats, ECH was detected in blood with a maximum concentration reached at <= 133 mM. ECH was cleared rapidly with a half-life of ca. 33 and 48 mm in males and females, respectively. Following a single oral dose of 25 mg/kg ECH in male and female rats, the elimination half-life of ECH was ca. 34 and 20 mm, respectively; the oral bioavailability of ECH was low (males, 5.2%; females, 2.1%), suggesting extensive first pass metabolism of ECH following oral administration. The area under the concentration vs time curve for ECH following oral administration of DCP and intravenous administration of ECH was used to estimate the percent of the DCP dose converted to ECH in rats. On the basis of this analysis, we concluded that in male and female rats following oral administration of 50 mg/kg DCP, >= 126% or >= 138% of the administered dose was metabolized to ECH, respectively.
C1 [Waidyanatha, Suramya] NIEHS, Div Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
   [Gaudette, Norman F.; Hong, Yan; Fennell, Timothy R.] RTI Int, Res Triangle Pk, NC 27709 USA.
RP Waidyanatha, S (reprint author), NIEHS, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA.
EM waidyanathas@niehs.nih.gov
FU National Toxicology Program, National Institute of Environmental Health
   Sciences, National Institutes of Health, Department of Health and Human
   Services [N01-ES-75563 (HHSN29120077563)]
FX This work was performed by RTI International (RTP, NC) for the National
   Toxicology Program, National Institute of Environmental Health Sciences,
   National Institutes of Health, Department of Health and Human Services,
   under contract no. N01-ES-75563 (HHSN29120077563).
NR 49
TC 0
Z9 0
U1 2
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD OCT
PY 2014
VL 27
IS 10
BP 1787
EP 1795
DI 10.1021/tx500239q
PG 9
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA AR3ZB
UT WOS:000343526700014
PM 25254956
ER

PT J
AU Miller, AC
   Ziad-Miller, A
   Elamin, EM
AF Miller, Andrew C.
   Ziad-Miller, Amna
   Elamin, Elamin M.
TI Brain Death and Islam The Interface of Religion, Culture, History, Law,
   and Modern Medicine
SO CHEST
LA English
DT Article
ID END-OF-LIFE; ORGAN DONATION; SAUDI-ARABIA; 10-YEAR EXPERIENCE; CARE;
   MUSLIM; TRANSPLANTATION; ETHICS; BIOETHICS; BELIEFS
AB How one defines death may vary. It is important for clinicians to recognize those aspects of a patient's religious beliefs that may directly influence medical care and how such practices may interface with local laws governing the determination of death. Debate continues about the validity and certainty of brain death criteria within Islamic traditions. A search of PubMed, Scopus, EMBASE, Web of Science, PsycNet, Sociological Abstracts, DIALOGUE ProQuest, Lexus Nexus, Google, and applicable religious texts was conducted to address the question of whether brain death is accepted as true death among Islamic scholars and clinicians and to discuss how divergent opinions may affect clinical care. The results of the literature review inform this discussion. Brain death has been acknowledged as representing true death by many Muslim scholars and medical organizations, including the Islamic Fiqh Academies of the Organization of the Islamic Conference and the Muslim World League, the Islamic Medical Association of North America, and other faith-based medical organizations as well as legal rulings by multiple Islamic nations. However, consensus in the Muslim world is not unanimous, and a sizable minority accepts death by cardiopulmonary criteria only.
C1 [Miller, Andrew C.] NIH, Crit Care Med Dept, Ctr Clin, Bethesda, MD 20892 USA.
   [Ziad-Miller, Amna] New York Law Sch, New York, NY USA.
   [Elamin, Elamin M.] James A Haley Vet Hosp, Div Pulm Crit Care & Sleep Med, Dept Internal Med, Tampa, FL 33612 USA.
   Univ S Florida, Tampa, FL USA.
RP Miller, AC (reprint author), NIH, Crit Care Med Dept, Ctr Clin, Bldg 10,Room 2C-145,10 Ctr Dr, Bethesda, MD 20892 USA.
EM Taqwa1@gmail.com
OI Miller, Andrew/0000-0001-8474-5090
FU Intramural Research Program of the Clinical Center, National Institutes
   of Health
FX This work was supported, in part, by the Intramural Research Program of
   the Clinical Center, National Institutes of Health.
NR 74
TC 7
Z9 7
U1 0
U2 18
PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD OCT
PY 2014
VL 146
IS 4
BP 1092
EP 1101
DI 10.1378/chest.14-0130
PG 10
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA AR4QD
UT WOS:000343570400041
PM 25287999
ER

PT J
AU Bitnun, A
   Samson, L
   Chun, TW
   Kakkar, F
   Brophy, J
   Murray, D
   Justement, S
   Soudeyns, H
   Ostrowski, M
   Mujib, S
   Harrigan, PR
   Kim, J
   Sandstrom, P
   Read, SE
AF Bitnun, Ari
   Samson, Lindy
   Chun, Tae-Wook
   Kakkar, Fatima
   Brophy, Jason
   Murray, Danielle
   Justement, Shawn
   Soudeyns, Hugo
   Ostrowski, Mario
   Mujib, Shariq
   Harrigan, P. Richard
   Kim, John
   Sandstrom, Paul
   Read, Stanley E.
TI Early Initiation of Combination Antiretroviral Therapy in HIV-1-Infected
   Newborns Can Achieve Sustained Virologic Suppression With Low Frequency
   of CD4(+) T Cells Carrying HIV in Peripheral Blood
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE child; combination antiretroviral therapy; eradication; HIV; proviral
   DNA
ID HUMAN-IMMUNODEFICIENCY-VIRUS; HLA CLASS-I; IMMUNE-RESPONSES; PLASMA
   VIREMIA; INFECTION; RESERVOIRS; CHILDREN; INFANTS; TYPE-1; INTERRUPTIONS
AB Background. A human immunodeficiency virus type 1 (HIV-1)-infected infant started on combination antiretroviral therapy (cART) at 30 hours of life was recently reported to have no detectable plasma viremia after discontinuing cART. The current study investigated the impact of early cART initiation on measures of HIV-1 reservoir size in HIV-1-infected children with sustained virologic suppression.
   Methods. Children born to HIV-1-infected mothers and started on cART within 72 hours of birth at 3 Canadian centers were assessed. HIV serology, HIV-1-specific cell-mediated immune responses, plasma viremia, cell-associated HIV-1 DNA and RNA, presence of replication-competent HIV-1, and HLA genotype were determined for HIV-1-infected children with sustained virologic suppression.
   Results. Of 136 cART-treated children, 12 were vertically infected (8.8%). In the 4 who achieved sustained virologic suppression, HIV serology, HIV-1-specific cell-mediated immune responses (Gag, Nef), and ultrasensitive viral load were negative. HIV-1 DNA was not detected in enriched CD4(+) T cells of the 4 children (<2.6 copies/10(6) CD4(+) T cells), whereas HIV-1 RNA was detected (19.5-130 copies/1.5 mu g RNA). No virion-associated HIV-1 RNA was detected following mitogenic stimulation of peripheral blood CD4(+) T cells (5.4-8.0 million CD4(+) T cells) in these 4 children, but replication competent virus was detected by quantitative co-culture involving a higher number of cells in 1 of 2 children tested (0.1 infectious units/10(6) CD4(+) T cells).
   Conclusions. In perinatally HIV-1-infected newborns, initiation of cART within 72 hours of birth may significantly reduce the size of the HIV-1 reservoirs. Cessation of cART may be necessary to determine whether functional HIV cure can be achieved in such children.
C1 [Bitnun, Ari; Read, Stanley E.] Univ Toronto, Dept Paediat, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Samson, Lindy; Brophy, Jason] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON K1N 6N5, Canada.
   [Chun, Tae-Wook; Murray, Danielle; Justement, Shawn] NIAID, NIH, Bethesda, MD 20892 USA.
   [Kakkar, Fatima] Univ Montreal, CHU St Justine, Dept Pediat, Quebec City, PQ, Canada.
   [Soudeyns, Hugo] Univ Montreal, CHU St Justine, Ctr Rech, Dept Microbiol Infectiol & Immunol, Quebec City, PQ, Canada.
   [Soudeyns, Hugo] Univ Montreal, Dept Pediat, Quebec City, PQ, Canada.
   [Ostrowski, Mario] Univ Toronto, Dept Immunol & Med, Toronto, ON M5G 1X8, Canada.
   [Ostrowski, Mario] St Michaels Hosp, Keenan Ctr Biomed Res, Toronto, ON M5B 1W8, Canada.
   [Mujib, Shariq] Univ Toronto, Dept Med, Inst Med Sci, Toronto, ON M5G 1X8, Canada.
   [Harrigan, P. Richard] Univ British Columbia, Dept Med, BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada.
   [Sandstrom, Paul] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Ottawa, ON, Canada.
RP Bitnun, A (reprint author), Univ Toronto, Div Infect Dis, Hosp Sick Children, Dept Paediat, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM ari.bitnun@sickkids.ca
FU Reseau SIDA et MI, Fonds de la recherche du Quebec-sante
FX H. S. was supported by an infrastructure grant from Reseau SIDA et MI,
   Fonds de la recherche du Quebec-sante.
NR 30
TC 23
Z9 23
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD OCT 1
PY 2014
VL 59
IS 7
BP 1012
EP 1019
DI 10.1093/cid/ciu432
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AR2JY
UT WOS:000343411900017
PM 24917662
ER

PT J
AU Liu, JM
   Pattanaik, S
   Yao, JH
   Turkbey, E
   Zhang, WD
   Zhang, X
   Summers, RM
AF Liu, Jiamin
   Pattanaik, Sanket
   Yao, Jianhua
   Turkbey, Evrim
   Zhang, Weidong
   Zhang, Xiao
   Summers, Ronald M.
TI Computer aided detection of epidural masses on computed tomography scans
SO COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
LA English
DT Article
DE Epidural mass; Computer aided detection; Gaussian mixture model;
   Supervoxel
ID CLASSIFICATION; FEATURES
AB The widespread use of CT imaging and the critical importance of early detection of epidural masses of the spinal canal generate a scenario ideal for the implementation of a computer-aided detection (CAD) system. Epidural masses can lead to paralysis, incontinence and loss of neurological function if not promptly detected. We present, to our knowledge, the first CAD system to detect epidural masses on CT scans. In this paper, spatially constrained Gaussian mixture model (GMM) and supervoxel-based method are proposed for epidural mass detection. The detection is performed on the Gaussian level or the supervoxel level rather than the voxel level. Cross-validation on 40 patients with epidural masses on body CT showed that the supervoxel-based method yielded a significant improvement of performance (82% at 3 false positives per patient) over the spatially constrained GMM method (55% at 3 false positives per patient). Published by Elsevier Ltd.
C1 [Liu, Jiamin; Pattanaik, Sanket; Yao, Jianhua; Turkbey, Evrim; Zhang, Weidong; Zhang, Xiao; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM rms@nih.gov
FU Intramural Research Program of the NIH Clinical Center
FX This research was supported by the Intramural Research Program of the
   NIH Clinical Center.
NR 13
TC 2
Z9 2
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0895-6111
EI 1879-0771
J9 COMPUT MED IMAG GRAP
JI Comput. Med. Imaging Graph.
PD OCT
PY 2014
VL 38
IS 7
SI SI
BP 606
EP 612
DI 10.1016/j.compmedimag.2014.04.007
PG 7
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA AR1MU
UT WOS:000343350100007
PM 24908192
ER

PT J
AU Yao, JH
   Burns, JE
   Munoz, H
   Summers, RM
AF Yao, Jianhua
   Burns, Joseph E.
   Munoz, Hector
   Summers, Ronald M.
TI Cortical shell unwrapping for vertebral body abnormality detection on
   computed tomography
SO COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
LA English
DT Article
DE Computer aided detection; Computational spine imaging
ID THORACOLUMBAR SPINE; AUTOMATED DETECTION; CT; SEGMENTATION; METASTASES;
   IMAGES; OSTEOPHYTES; ALGORITHM
AB The vertebral body is the main axial load-bearing structure of the spinal vertebra. Assessment of acute injury and chronic deformity of the vertebral body is difficult to assess accurately and quantitatively by simple visual inspection. We propose a cortical shell unwrapping method to examine the vertebral body for injury such as fractures and degenerative osteophytes. The spine is first segmented and partitioned into vertebrae. Then the cortical shell of the vertebral body is extracted using deformable dual-surface models. The cortical shell is then unwrapped onto a 2D map and the complex 3D detection problem is effectively converted to a pattern recognition problem on a 2D plane. Characteristic features adapted for different applications are computed and sent to a committee of support vector machines for classification. The system was evaluated on two applications, one for fracture detection on trauma CT datasets and the other on degenerative osteophyte assessment on sodium fluoride PET/CT. The fracture CAD achieved 93.6% sensitivity at 3.2 false positive per patient and the degenerative osteophyte CAD achieved 82% sensitivity at 4.7 false positive per patient. Published by Elsevier Ltd.
C1 [Yao, Jianhua; Munoz, Hector; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
   [Burns, Joseph E.] Univ Calif Irvine, Sch Med, Dept Radiol Sci, Irvine, CA 92868 USA.
RP Yao, JH (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
EM jyao@cc.nih.gov
FU Intramural Research Program at National Institutes of Health, Clinical
   Center
FX This work was supported by the Intramural Research Program at National
   Institutes of Health, Clinical Center.
NR 31
TC 1
Z9 1
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0895-6111
EI 1879-0771
J9 COMPUT MED IMAG GRAP
JI Comput. Med. Imaging Graph.
PD OCT
PY 2014
VL 38
IS 7
SI SI
BP 628
EP 638
DI 10.1016/j.compmedimag.2014.04.001
PG 11
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA AR1MU
UT WOS:000343350100010
PM 24815367
ER

PT J
AU Majumdar, R
   Sixt, M
   Parent, CA
AF Majumdar, Ritankar
   Sixt, Michael
   Parent, Carole A.
TI New paradigms in the establishment and maintenance of gradients during
   directed cell migration
SO CURRENT OPINION IN CELL BIOLOGY
LA English
DT Article
ID NUCLEOTIDE PHOSPHODIESTERASE GENE; EUKARYOTIC CHEMOTAXIS; IN-VIVO;
   NEUTROPHIL RECRUITMENT; CHEMOKINE RECEPTOR; MORPHOGEN GRADIENT;
   GUIDANCE; INFLAMMATION; HEDGEHOG; TISSUE
AB Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients present and act in the context of an organism is far less clear. Here we review recent advances in understanding how guidance cues emerge and operate in complex physiological settings.
C1 [Majumdar, Ritankar; Parent, Carole A.] NCI, Cellular & Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Sixt, Michael] IST Austria, A-3400 Klostemeuburg, Austria.
RP Parent, CA (reprint author), NCI, Cellular & Mol Biol Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA.
EM parentc@mail.nih.gov
OI Sixt, Michael/0000-0002-6620-9179; Majumdar,
   Ritankar/0000-0001-6624-0187
FU Intramural Research Program of the Center for Cancer Research, NCI,
   National Institutes of Health; European Research Council (ERC)
FX We thank members of the Parent and Sixt groups for helpful discussions.
   We apologize to authors whose recent work could not be included in this
   review. This effort was supported by the Intramural Research Program of
   the Center for Cancer Research, NCI, National Institutes of Health and
   the European Research Council (ERC).
NR 74
TC 15
Z9 15
U1 0
U2 22
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0955-0674
EI 1879-0410
J9 CURR OPIN CELL BIOL
JI Curr. Opin. Cell Biol.
PD OCT
PY 2014
VL 30
BP 33
EP 40
DI 10.1016/j.ceb.2014.05.010
PG 8
WC Cell Biology
SC Cell Biology
GA AR5JD
UT WOS:000343620300006
PM 24959970
ER

PT J
AU Cui, CY
   Yin, MZ
   Sima, J
   Childress, V
   Michel, M
   Piao, Y
   Schlessinger, D
AF Cui, Chang-Yi
   Yin, Mingzhu
   Sima, Jian
   Childress, Victoria
   Michel, Marc
   Piao, Yulan
   Schlessinger, David
TI Involvement of Wnt, Eda and Shh at defined stages of sweat gland
   development
SO DEVELOPMENT
LA English
DT Article
DE Exocrine gland; Skin appendage; Hair follicle; Ectodermal dysplasia;
   Heatstroke; Hyperhidrosis; Mouse
ID HAIR FOLLICLE DEVELOPMENT; SKIN APPENDAGE DEVELOPMENT; NF-KAPPA-B;
   SONIC-HEDGEHOG; MAMMARY-GLAND; BETA-CATENIN; BRANCHING MORPHOGENESIS;
   ECTODYSPLASIN; PATHWAY; MICE
AB To maintain body temperature, sweat glands develop from embryonic ectoderm by a poorly defined mechanism. We demonstrate a temporal cascade of regulation during mouse sweat gland formation. Sweat gland induction failed completely when canonical Wnt signaling was blocked in skin epithelium, and was accompanied by sharp downregulation of downstream Wnt, Eda and Shh pathway genes. The Wnt antagonist Dkk4 appeared to inhibit this induction: Dkk4 was sharply downregulated in beta-catenin-ablated mice, indicating that it is induced by Wnt/beta-catenin; however, its overexpression repressed Wnt target genes and significantly reduced gland numbers. Eda signaling succeeded Wnt. Wnt signaling was still active and nascent sweat gland pre-germs were still seen in Eda-null mice, but the pre-germs failed to develop further and the downstream Shh pathway was not activated. When Wnt and Eda were intact but Shh was ablated, germ induction and subsequent duct formation occurred normally, but the final stage of secretory coil formation failed. Thus, sweat gland development shows a relay of regulatory steps initiated by Wnt/beta-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways.
C1 [Cui, Chang-Yi; Yin, Mingzhu; Sima, Jian; Childress, Victoria; Michel, Marc; Piao, Yulan; Schlessinger, David] NIA, Genet Lab, NIH, Baltimore, MD 21224 USA.
RP Cui, CY (reprint author), NIA, Genet Lab, NIH, Baltimore, MD 21224 USA.
EM cuic@mail.nih.gov
FU National Institute on Aging, National Institutes of Health
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging, National Institutes of Health. Deposited in
   PMC for release after 12 months.
NR 51
TC 7
Z9 7
U1 0
U2 7
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 0950-1991
EI 1477-9129
J9 DEVELOPMENT
JI Development
PD OCT
PY 2014
VL 141
IS 19
BP 3752
EP 3760
DI 10.1242/dev.109231
PG 9
WC Developmental Biology
SC Developmental Biology
GA AR2LR
UT WOS:000343418800015
PM 25249463
ER

EF