FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Route, WT Russell, RE Lindstrom, AB Strynar, MJ Key, RL AF Route, William T. Russell, Robin E. Lindstrom, Andrew B. Strynar, Mark J. Key, Rebecca L. TI Spatial and Temporal Patterns in Concentrations of Perfluorinated Compounds in Bald Eagle Nestlings in the Upper Midwestern United States (vol 48, pg 6653, 2014) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Correction C1 [Route, William T.; Key, Rebecca L.] Natl Pk Serv, Great Lakes Inventory & Monitoring Network, Ashland, WI 54806 USA. [Russell, Robin E.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA. [Lindstrom, Andrew B.; Strynar, Mark J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Route, WT (reprint author), Natl Pk Serv, Great Lakes Inventory & Monitoring Network, Suite D,2800 Lake Shore Dr East, Ashland, WI 54806 USA. NR 1 TC 0 Z9 0 U1 3 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 19 PY 2014 VL 48 IS 16 BP 9957 EP 9957 DI 10.1021/es503206c PG 1 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AN6JW UT WOS:000340701800127 ER PT J AU Pleil, JD Sobus, JR Stiegel, MA Hu, D Oliver, KD Olenick, C Strynar, M Clark, M Madden, MC Funk, WE AF Pleil, Joachim D. Sobus, Jon R. Stiegel, Matthew A. Hu, Di Oliver, Karen D. Olenick, Cassandra Strynar, Mark Clark, Mary Madden, Michael C. Funk, William E. TI Estimating Common Parameters of Lognormally Distributed Environmental and Biomonitoring Data: Harmonizing Disparate Statistics From Publications SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID POLYCYCLIC AROMATIC-HYDROCARBONS; PARTICULATE AIR-POLLUTION; VOLATILE ORGANIC BIOMARKERS; EXHALED BREATH CONDENSATE; 1995 SOUTHERN OXIDANTS; NECROSIS-FACTOR-ALPHA; RISK-ASSESSMENT; PERFLUORINATED COMPOUNDS; EPIDEMIOLOGIC EVIDENCE; ARSENIC EXPOSURE AB The progression of science is driven by the accumulation of knowledge and builds upon published work of others. Another important feature is to place current results into the context of previous observations. The published literature, however, often does not provide sufficient direct information for the reader to interpret the results beyond the scope of that particular article. Authors tend to provide only summary statistics in various forms, such as means and standard deviations, median and range, quartiles, 95% confidence intervals, and so on, rather than providing measurement data. Second, essentially all environmental and biomonitoring measurements have an underlying lognormal distribution, so certain published statistical characterizations may be inappropriate for comparisons. The aim of this study was to review and develop direct conversions of different descriptions of data into a standard format comprised of the geometric mean (GM) and the geometric standard deviation (GSD) and then demonstrate how, under the assumption of lognormal distribution, these parameters are used to answer questions of confidence intervals, exceedance levels, and statistical differences among distributions. A wide variety of real-world measurement data sets was reviewed, and it was demonstrated that these data sets are indeed of lognormal character, thus making them amenable to these methods. Potential errors incurred from making retrospective estimates from disparate summary statistics are described. In addition to providing tools to interpret "other people's data," this review should also be seen as a cautionary tale for publishing one's own data to make it as useful as possible for other researchers. C1 [Pleil, Joachim D.; Sobus, Jon R.; Oliver, Karen D.; Strynar, Mark] US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. [Stiegel, Matthew A.] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA. [Hu, Di] US EPA, NERL ORD, Res Triangle Pk, NC 27711 USA. [Olenick, Cassandra] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Clark, Mary] North Carolina Dept Environm & Nat Resources, Raleigh, NC USA. [Madden, Michael C.] US EPA, Environm Publ Hlth Div, NHEERL ORD, Res Triangle Pk, NC 27711 USA. [Funk, William E.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. RP Pleil, JD (reprint author), US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. EM pleil@email.unc.edu NR 105 TC 12 Z9 12 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PD AUG 18 PY 2014 VL 17 IS 6 BP 341 EP 368 DI 10.1080/10937404.2014.956854 PG 28 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AR1AH UT WOS:000343310600002 PM 25333994 ER PT J AU Pokhrel, LR Andersen, CP Rygiewicz, PT Johnson, MG AF Pokhrel, Lok R. Andersen, Christian P. Rygiewicz, Paul T. Johnson, Mark G. TI Preferential interaction of Na+ over K+ with carboxylate-functionalized silver nanoparticles SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Hofmeister series; silver nanoparticles; monovalent cations; interaction preference; colloidal stability ID X-RAY-ABSORPTION; COLLOIDAL STABILITY; SURFACE-CHARGE; DIVALENT-CATIONS; TOXICITY; AGGREGATION; DISSOLUTION; MONOVALENT; CITRATE; PH AB Elucidating mechanistic interactions between monovalent cations (Na+/K+) and engineered nanoparticle surfaces to alter particle stability in polar media have received little attention. We investigated relative preferential interaction of Na+ and K+ with carboxylate-functionalized silver nanoparticles (carboxylate-AgNPs) to determine if interaction preference followed the Hofmeister series (Na+ > K+). We hypothesized that Na+ will show greater affinity than K+ to pair with carboxylates on AgNP surfaces, thereby destabilizing the colloidal system. Destabilization upon Na+ or K+ interacting with carboxylate-AgNPs was evaluated probing changes in multiple physicochemical characteristics: surface plasmon resonance/optical absorbance, electrical conductivity, pH, hydrodynamic diameter, electrophoretic mobility, surface charge, amount of Na+/K+ directly associated with AgNPs, and Ag+ dissociation kinetics. We show that Na+ and K+ react differently, indicating local Na+ pairing with carboxylates on AgNP surfaces is kinetically faster and remarkably favored over K+, thus supporting Hofmeister ordering. Our results suggest that AgNPs may transform into micron-size aggregates upon release into aqueous environments and that the fate of such aggregates may need consideration when assessing environmental risk. (C) 2014 Elsevier B.V. All rights reserved. C1 [Pokhrel, Lok R.] CNR, Washington, DC 20001 USA. [Pokhrel, Lok R.; Andersen, Christian P.; Rygiewicz, Paul T.; Johnson, Mark G.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. RP Pokhrel, LR (reprint author), CNR, US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM Pokhrel.Lok@epa.gov OI Pokhrel, Lok/0000-0002-4606-9973 FU U.S. Environmental Protection Agency FX This research was funded by the U.S. Environmental Protection Agency. L.R.P. thanks J. Gaynor (University of Portland) for assistance in the laboratory; K. Langworthy and S. Golledge (CAMCOR, University of Oregon) for TEM and XPS analyses, respectively; R. King (Dynamac Corporation) for ICP-AES analysis; and three anonymous reviewers for their insightful feedback. This work was subject to review by the EPA National Health and Environmental Effects Research Laboratory at the Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the view of EPA, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 39 TC 2 Z9 2 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD AUG 15 PY 2014 VL 490 BP 11 EP 18 DI 10.1016/j.scitotenv.2014.04.120 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA AY0NT UT WOS:000347293800002 PM 24840275 ER PT J AU Jones, DK Baker, ME Miller, AJ Jarnagin, ST Hogan, DM AF Jones, Daniel K. Baker, Matthew E. Miller, Andrew J. Jarnagin, S. Taylor Hogan, Dianna M. TI Tracking geomorphic signatures of watershed suburbanization with multitemporal LiDAR SO GEOMORPHOLOGY LA English DT Article DE LiDAR time series; Urbanization; Land cover change; Digital elevation models; Anthropogenic geomorphology; Watershed ID DIGITAL ELEVATION MODELS; DRAINAGE NETWORKS; HEADWATER STREAMS; CHANNEL NETWORKS; URBANIZATION; EXTRACTION; LANDSCAPE; PATTERNS AB Urban development practices redistribute surface materials through filling, grading, and terracing, causing drastic changes to the geomorphic organization of the landscape. Many studies document the hydrologic, biologic, or geomorphic consequences of urbanization using space-for-time comparisons of disparate urban and rural landscapes. However, no previous studies have documented geomorphic changes from development using multiple dates of high-resolution topographic data at the watershed scale. This study utilized a time series of five sequential light detection and ranging (LiDAR) derived digital elevation models (DEMs) to track watershed geomorphic changes within two watersheds throughout development (2002-2008) and across multiple spatial scales (0.01-1 km(2)). Development-induced changes were compared against an undeveloped forested watershed during the same time period. Changes in elevations, slopes, hypsometry, and surface flow pathways were tracked throughout the development process to assess watershed geomorphic alterations. Results suggest that development produced an increase in sharp topographic breaks between relatively flat surfaces and steep slopes, replacing smoothly varying hillslopes and leading to greater variation in slopes. Examinations of flowpath distributions highlight systematic modifications that favor rapid convergence in unchanneled upland areas. Evidence of channel additions in the form of engineered surface conduits is apparent in comparisons of pre- and post-development stream maps. These results suggest that topographic modification, in addition to impervious surfaces, contributes to altered hydrologic dynamics observed in urban systems. This work highlights important considerations for the use of repeat LiDAR flights in analyzing watershed change through time. Novel methods introduced here may allow improved understanding and targeted mitigation of the processes driving geomorphic changes during development and help guide future research directions for development-based watershed studies. Published by Elsevier B.V. C1 [Jones, Daniel K.; Hogan, Dianna M.] US Geol Survey, Eastern Geog Sci Ctr, Reston, VA 20192 USA. [Jones, Daniel K.; Baker, Matthew E.; Miller, Andrew J.] Univ Maryland Baltimore Cty, Dept Geog & Environm Syst, Baltimore, MD 21250 USA. [Jarnagin, S. Taylor] US EPA, Landscape Ecol Branch, Div Environm Sci, USEPA ORD Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Jones, DK (reprint author), US Geol Survey, Eastern Geog Sci Ctr, 12201 Sunrise Valley Dr, Reston, VA 20192 USA. EM dkjones@usgs.gov; mbaker@umbc.edu; miller@umbc.edu; jarnagin.taylor@epa.gov; dhogan@usgs.gov RI Baker, Matthew/I-2839-2014 OI Baker, Matthew/0000-0001-5069-0204 FU U.S. Environmental Protection Agency [EP-D-05-088] FX LiDAR funding provided in part by the U.S. Environmental Protection Agency under contract number EP-D-05-088 to Lockheed Martin. The U.S. Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. This manuscript has been subjected to Agency review and approved for publication. This work would not have been possible without the Clarksburg Integrated Study Partnership, which includes the U.S. Environmental Protection Agency Landscape Ecology Branch (USEPA LEB), Montgomery County Department of Environmental Protection (PEP), the U.S. Geological Survey Eastern Geographic Science Center (USGS EGSC), the University of Maryland (UMD), and the University of Maryland, Baltimore County (UMBC). We would like to thank Adam Bentham, Richard Marston, and one anonymous referee for providing constructive feedback on our paper during the review process. NR 53 TC 8 Z9 8 U1 3 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X EI 1872-695X J9 GEOMORPHOLOGY JI Geomorphology PD AUG 15 PY 2014 VL 219 BP 42 EP 52 DI 10.1016/j.geomorph.2014.04.038 PG 11 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA AM3TG UT WOS:000339775100004 ER PT J AU Al Anazi, AH Nadagouda, MN Han, C Dionysiou, DD Takkellapati, SR AF Al Anazi, Abdulaziz H. Nadagouda, Mallikarjuna N. Han, Changseok Dionysiou, Dionysios D. Takkellapati, Sudhakar R. TI Synthesis of innovative ferrite-based recyclable catalyst to degrade water contaminants of emerging concern SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Al Anazi, Abdulaziz H.; Han, Changseok; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [Nadagouda, Mallikarjuna N.] US EPA, ORD, NRMRL, WSWRD, Cincinnati, OH 45268 USA. [Takkellapati, Sudhakar R.] US EPA, ORD, NRMRL, STD, Cincinnati, OH 45268 USA. EM azizalanazi@gmail.com; dionysdd@ucmail.uc.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 597-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106151 ER PT J AU Baig, NBR Varma, RS AF Baig, Nasir Baig R. Varma, Rajender S. TI Biodegradable polymer supported heterogeneous catalysis and their applications in organic synthesis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Baig, Nasir Baig R.; Varma, Rajender S.] US EPA, Natl Risk ManagementRes Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. EM nasirchem@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 223-CATL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165102488 ER PT J AU Baig, NBR Varma, RS AF Baig, Nasir Baig R. Varma, Rajender S. TI Magnetic silica supported copper: A modular approach to aqueous Ullmann-type amination of aryl halides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Baig, Nasir Baig R.; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk ManagementRes Lab, Cincinnati, OH 45268 USA. EM nasirchem@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 161-CATL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165102431 ER PT J AU Baris, R Barrett, MR Bohaty, R Cowles, J Echeverria, M Shelby, A Wolf, J Young, DF AF Baris, Reuben Barrett, Michael R. Bohaty, Rochelle Cowles, James Echeverria, Marietta Shelby, Andrew Wolf, James Young, Dirk F. TI Implementation of the Pesticide Root Zone Model Groundwater for use in EPA's pesticide exposure assessments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Baris, Reuben; Barrett, Michael R.; Bohaty, Rochelle; Cowles, James; Echeverria, Marietta; Shelby, Andrew; Wolf, James; Young, Dirk F.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. EM bohaty.rochelle@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 763-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101222 ER PT J AU Barrett, MR Bohaty, R Cowles, J Shelby, A Wolf, J Young, DF AF Barrett, Michael R. Bohaty, Rochelle Cowles, James Shelby, Andrew Wolf, James Young, Dirk F. TI Case study comparisons of monitoring data with PRZM-GW predictions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Barrett, Michael R.; Bohaty, Rochelle; Cowles, James; Shelby, Andrew; Wolf, James; Young, Dirk F.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. EM barrett.michael@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 784-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101241 ER PT J AU BeigzadeMilani, S Hou, WC Bitter, JL Zepp, RG Fairbrother, H Jafvert, CT AF BeigzadeMilani, Somayeh Hou, Wen-Che Bitter, Julie L. Zepp, Richard G. Fairbrother, Howard Jafvert, Chad T. TI Photochemical fate of single-walled carbon nanotubes in the aquatic environment SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [BeigzadeMilani, Somayeh; Jafvert, Chad T.] Purdue Univ, Lyles Sch Civil Engn, W Lafayette, IN 47906 USA. [Hou, Wen-Che] Natl Cheng Kung Univ, Dept Environm Engn, Tainan 70101, Taiwan. [Bitter, Julie L.; Fairbrother, Howard] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA. [Zepp, Richard G.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. EM sbeigzad@purdue.edu; jafvert@ecn.purdue.edu RI Hou, Wen-Che/F-5736-2011 OI Hou, Wen-Che/0000-0001-9884-2932 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 125-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105560 ER PT J AU Bireley, R Hart, C Hou, W Garber, K Steeger, T AF Bireley, Richard Hart, Connie Hou, Wayne Garber, Kristina Steeger, Thomas TI Assessing the potential for adverse effects to bees from exposure to pesticides: Integrating multiple lines of evidence across varying levels of biological organization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Garber, Kristina; Steeger, Thomas] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. [Hart, Connie; Hou, Wayne] Hlth Canada Pest Management Regulatory Agcy, Environm Assessment Directorate, Ottawa, ON, Canada. [Bireley, Richard] Calif Dept Pesticide Regulatoin, Sacramento, CA 95812 USA. EM rbireley@cdpr.ca.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 707-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101168 ER PT J AU Bouchard, D Chang, XJ Knightes, C Chowdhury, I AF Bouchard, Dermont Chang, Xiaojun Knightes, Christopher Chowdhury, Indranil TI Parameterizing water quality analysis and simulation program (WASP) for carbon-based nanomaterials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Bouchard, Dermont; Chang, Xiaojun; Knightes, Christopher; Chowdhury, Indranil] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. EM Chowdhury.Indranil@epa.gov NR 0 TC 0 Z9 0 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 257-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105684 ER PT J AU Briskin, J AF Briskin, Jeanne TI EPA's study of the potential impacts of hydraulic fracturing on drinking water resources SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Briskin, Jeanne] US EPA, Off Res & Dev, Washington, DC 20460 USA. EM briskin.jeanne@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 893-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400206 ER PT J AU Dawson, JL AF Dawson, Jeffrey L. TI EPA pesticide risk assessment methods for spray drift and volatilization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Dawson, Jeffrey L.] US EPA, OCSPP, Off Pesticide Programs, Washington, DC 20460 USA. EM dawson.jeff@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 892-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101347 ER PT J AU DeMessie, BB Sahle-Demessie, E Sorial, GA AF DeMessie, Bluye' B. Sahle-Demessie, Endalkachew Sorial, George A. TI Sustainable and low cost approach for cleaning metal contaminated water using pyrolyzed banana peels biochars SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [DeMessie, Bluye' B.; Sorial, George A.] Univ Cincinnati, Dept Environm Engn, Cincinnati, OH 45220 USA. [Sahle-Demessie, Endalkachew] US EPA, Off Res & Developement, Cincinnati, OH 45268 USA. EM demessiem@aol.com NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 240-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105667 ER PT J AU Eckel, WP Bohaty, RFH Shamim, M White, K Young, DF AF Eckel, William P. Bohaty, Rochelle F. H. Shamim, Mah White, Katrina Young, Dirk F. TI Standard operating procedure for calculating degradation kinetics in EPA's Office of Pesticide Programs SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Eckel, William P.; Bohaty, Rochelle F. H.; Shamim, Mah; White, Katrina; Young, Dirk F.] US EPA, Off Pesticide Programs, Arlington, VA 22202 USA. EM eckel.william@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 992-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101441 ER PT J AU Ellenberger, JS AF Ellenberger, Jay S. TI NAFTA Technical Working Group: Successful cooperation on pesticide regulatory issues SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Ellenberger, Jay S.] US EPA, Off Pesticide Programs, Field & External Affairs Div, Arlington, VA 22202 USA. EM ellenberger.jay@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 140-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100508 ER PT J AU Fry, M Young, D Thurman, N AF Fry, Meridith Young, Dirk Thurman, Nelson CA Spatial Aquatic Model Project Team TI Development and validation of the Spatial Aquatic Model for spatially-explicit exposure assessments in the United States SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Fry, Meridith; Young, Dirk; Thurman, Nelson; Spatial Aquatic Model Project Team] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Washington, DC 20460 USA. EM fry.meridith@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 767-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101226 ER PT J AU Garcia-Reyero, N Habib, T Villeneuve, D Escalon, L Ankley, G Perkins, E AF Garcia-Reyero, Natalia Habib, Tanwir Villeneuve, Daniel Escalon, Lynn Ankley, Gerald Perkins, Edward TI Systems approach to detect and evaluate contaminants of emerging concern in the Great Lakes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX USA. [Villeneuve, Daniel; Ankley, Gerald] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. [Escalon, Lynn; Perkins, Edward] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM nvinas@igbb.msstate.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 9-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105454 ER PT J AU Gawande, MB Rathi, AK Kvitek, LB Varma, RS Zboril, RB AF Gawande, Manoj B. Rathi, Anuj K. Kvitek, Libor B. Varma, Rajender S. Zboril, Radek B. TI Advanced nanomaterials: Sustainable preparations and their catalytic applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc ID NANOCATALYST C1 [Gawande, Manoj B.; Rathi, Anuj K.; Kvitek, Libor B.; Zboril, Radek B.] Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, CR-77147 Olomouc, Czech Republic. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM mbgawande@gmail.com RI Zboril, Radek/F-5153-2015 NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 418-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167403012 ER PT J AU Gilliom, R Corbin, M Nowell, L Sandstrom, M Qian, YR Hladik, M AF Gilliom, Robert Corbin, Mark Nowell, Lisa Sandstrom, Mark Qian, Yaorong Hladik, Michelle TI Occurrence and characterization of pesticide mixtures in central US streams and rivers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Gilliom, Robert; Nowell, Lisa; Sandstrom, Mark; Hladik, Michelle] US Geol Survey, Washington, DC USA. [Corbin, Mark; Qian, Yaorong] US EPA, Washington, DC USA. EM rgilliom@usgs.gov NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 905-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101359 ER PT J AU Glinski, DA Van Meter, R Henderson, WM Purucker, ST AF Glinski, Donna A. Van Meter, Robin Henderson, W. Matthew Purucker, S. Thomas TI Pesticide detection in rainwater, stemflow, and amphibians from agricultural spray-drift in southern Georgia, USA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Glinski, Donna A.] US EPA, Athens, GA 30605 USA. [Van Meter, Robin] Washington Coll, Dept Biol, Chestertown, MD 21620 USA. [Henderson, W. Matthew; Purucker, S. Thomas] US EPA, ORD, NERL, ERD, Athens, GA 30605 USA. EM glinski.donna@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 496-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100850 ER PT J AU Golden, PE AF Golden, Paul E. TI EPA efforts to update OCSPP multi-residue chemistry test guidelines underway SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Golden, Paul E.] US EPA, Off Pesticide Programs, Ft George G Meade, MD 20755 USA. EM golden.paul@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 579-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101045 ER PT J AU Gonzalez, MA AF Gonzalez, Michael A. TI Chemistry and its role in sustainability SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Gonzalez, Michael A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM gonzalez.michael@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 50-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400483 ER PT J AU Guiney, LM Mansukhani, ND Duch, MC Chowdhury, I Bouchard, D Wang, X Ji, ZX Nel, A Hersam, MC AF Guiney, Linda M. Mansukhani, Nikhita D. Duch, Matthew C. Chowdhury, Indranil Bouchard, Dermont Wang, Xiang Ji, Zhaoxia Nel, Andre Hersam, Mark C. TI Investigating the toxicity and environmental fate of graphene nanomaterials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Guiney, Linda M.; Mansukhani, Nikhita D.; Duch, Matthew C.; Hersam, Mark C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. [Chowdhury, Indranil; Bouchard, Dermont] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Wang, Xiang; Ji, Zhaoxia; Nel, Andre] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA. EM LindaGuiney2012@u.northwestern.edu RI Hersam, Mark/B-6739-2009 NR 0 TC 0 Z9 0 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 123-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105558 ER PT J AU Henderson, WMM Chowdhury, I Chang, XJ Teng, Q Bouchard, D AF Henderson, W. Matthew M. Chowdhury, Indranil Chang, Xiaojun Teng, Quincy Bouchard, Dermont TI Developing exposure indices of graphene-based nanoparticles by coupling lipid-membrane interactions and in vitro cellular response SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Henderson, W. Matthew M.; Teng, Quincy; Bouchard, Dermont] US EPA, ORD NERL ERD, Athens, GA 30605 USA. [Chowdhury, Indranil; Chang, Xiaojun] Grantee US Environm Protect Agcy, Athens, GA 30605 USA. EM henderson.matt@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 120-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105555 ER PT J AU Holder, CD Al-Abed, SR Pinto, PX AF Holder, Christopher D. Al-Abed, Souhail R. Pinto, Patricio X. TI Reuse of industrial lead-contaminated soil in urban applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Holder, Christopher D.; Pinto, Patricio X.] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM holder.christopher@epa.gov NR 0 TC 0 Z9 0 U1 3 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 873-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400186 ER PT J AU Hou, WC Chowdhury, I Goodwin, D Henderson, M Fairbrother, H Bouchard, D Zepp, R AF Hou, Wen-Che Chowdhury, Indranil Goodwin, David Henderson, Matthew Fairbrother, Howard Bouchard, Dermont Zepp, Richard TI Direct and indirect phototransformations of graphene oxide in sunlight SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Hou, Wen-Che; Chowdhury, Indranil; Henderson, Matthew; Bouchard, Dermont; Zepp, Richard] US EPA, Ecosyst Res Div, Athens, GA 30605 USA. [Goodwin, David; Fairbrother, Howard] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA. [Hou, Wen-Che] Natl Cheng Kung Univ, Dept Environm Engn, Tainan 70101, Taiwan. EM whou@mail.ncku.edu.tw RI Hou, Wen-Che/F-5736-2011 OI Hou, Wen-Che/0000-0001-9884-2932 NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 124-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105559 ER PT J AU Mansouri, K Sipes, N Nicolas, C Judson, R AF Mansouri, Kamel Sipes, Nisha Nicolas, Chantel Judson, Richard TI In-silico study of ToxCast GPCR assays by quantitative structure-activity relationships (QSARs) modeling SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Mansouri, Kamel; Sipes, Nisha; Nicolas, Chantel; Judson, Richard] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27111 USA. [Mansouri, Kamel; Sipes, Nisha; Nicolas, Chantel] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. EM mansouri.kamel@epa.gov NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 163-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105596 ER PT J AU Moran, KD TenBrook, PL AF Moran, Kelly D. TenBrook, Patti L. TI Sources of pesticides in urban runoff and wastewater discharges: A conceptual model SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Moran, Kelly D.] TDC Environm LLC, San Mateo, CA 94403 USA. [TenBrook, Patti L.] US EPA, San Francisco, CA 94105 USA. EM kmoran@tdcenvironmental.com; TenBrook.Patti@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 218-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100583 ER PT J AU Murphy, EW Wellenkamp, W Johnson, J Holsen, TM Hopke, PK Crimmins, BS Pagano, JJ Milligan, MS AF Murphy, Elizabeth W. Wellenkamp, William Johnson, James Holsen, Thomas M. Hopke, Philip K. Crimmins, Bernard S. Pagano, James J. Milligan, Michael S. TI Contaminant concentration of Great Lakes lake trout: Are they affected by changes in growth as a function of the changing food web SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Murphy, Elizabeth W.] US EPA, Great Lakes Natl Program Off, Chicago, IL 60604 USA. [Wellenkamp, William; Johnson, James] Michigan Dept Nat Resources, Alpena Fisheries Res Stn, Alpena, MI 49707 USA. [Holsen, Thomas M.; Hopke, Philip K.; Crimmins, Bernard S.] Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA. [Pagano, James J.] SUNY Coll Oswego, Dept Chem, Oswego, NY 13126 USA. [Milligan, Michael S.] SUNY Coll Fredonia, Dept Chem, Fredonia, NY 14063 USA. EM murphy.elizabeth@epa.gov RI Hopke, Philip/C-6020-2008 OI Hopke, Philip/0000-0003-2367-9661 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 81-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105519 ER PT J AU Negron-Encarnacion, I Olinger, C Kolanczyk, R Schmieder, P Metzger, M Kent, R Jones, J AF Negron-Encarnacion, Ideliz Olinger, Christine Kolanczyk, Richard Schmieder, Patricia Metzger, Michael Kent, Ray Jones, Jack TI MetaPath: A metabolism database to support the pesticide risk assessment process SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Negron-Encarnacion, Ideliz; Olinger, Christine; Metzger, Michael; Kent, Ray] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. [Kolanczyk, Richard; Schmieder, Patricia] US EPA, Off Res & Dev, Midcontinent Ecol Res Lab, Duluth, MN USA. [Jones, Jack] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA USA. EM encarnacion.ideliz@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 94-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100463 ER PT J AU Nicolas, CI Goldsmith, MR Ahir, BK Wetmore, BA Dionisio, KL Mansouri, K Setzer, RW Judson, RS Rabinowitz, J Wambaugh, JF AF Nicolas, Chantel I. Goldsmith, Michael R. Ahir, Bhavesh K. Wetmore, Barbara A. Dionisio, Kathie L. Mansouri, Kamel Setzer, R. Woodrow Judson, Richard S. Rabinowitz, James Wambaugh, John F. TI High-throughput exposure modeling of semi-volatile chemicals in articles of commerce SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Nicolas, Chantel I.; Ahir, Bhavesh K.; Mansouri, Kamel; Setzer, R. Woodrow; Judson, Richard S.; Rabinowitz, James; Wambaugh, John F.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Goldsmith, Michael R.; Dionisio, Kathie L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Wetmore, Barbara A.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA. [Nicolas, Chantel I.; Ahir, Bhavesh K.; Mansouri, Kamel] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. EM nicolas.chantel@epa.gov NR 2 TC 0 Z9 0 U1 2 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 160-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105594 ER PT J AU Odenkirchen, EW AF Odenkirchen, Edward W. TI Assessing risks to endangered and threatened species from pesticides: An update on interim approaches and implementation SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Odenkirchen, Edward W.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. EM odenkirchen.edward@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 962-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101411 ER PT J AU Peak, D Betts, AR Hamilton, JG Farrell, RE AF Peak, Derek Betts, Aaron R. Hamilton, Jordan G. Farrell, Richard E. TI Field and molecular-scale evaluation of bonemeal biochar as a remediation amendment for Zn in smelter affected soils SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Peak, Derek; Hamilton, Jordan G.; Farrell, Richard E.] Univ Saskatchewan, Dept Soil Sci, Saskatoon, SK S7N5A8, Canada. [Betts, Aaron R.] Environm Protect Agcy, Cincinnati, OH 45224 USA. EM derek.peak@usask.ca NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 739-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400063 ER PT J AU Peck, C Farruggia, FT Jones, RD Wolf, JK Thurman, NC Hetrick, JA AF Peck, Charles Farruggia, Frank T. Jones, R. David Wolf, James K. Thurman, Nelson C. Hetrick, James A. TI Overview of statistical methods to quantify uncertainty of pesticide concentrations in surface water monitoring data SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Peck, Charles; Farruggia, Frank T.; Jones, R. David; Wolf, James K.; Thurman, Nelson C.; Hetrick, James A.] US EPA, Off Pesticide Programs, Arlington, VA 21462 USA. EM peck.charles@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 786-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101243 ER PT J AU Peck, C White, KE Biscoe, ML Fry, M Hetrick, J Ruhman, M Shelby, A Thurman, N Young, D AF Peck, Charles White, Katrina E. Biscoe, Melanie L. Fry, Meridith Hetrick, Jim Ruhman, Mohammed Shelby, Andrew Thurman, Nelson Young, Dirk TI Development of conceptual models for estimating aquatic exposure from the use of pesticides on rice using the Pesticide Flooded Application Model SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Peck, Charles; White, Katrina E.; Biscoe, Melanie L.; Fry, Meridith; Hetrick, Jim; Ruhman, Mohammed; Shelby, Andrew; Thurman, Nelson; Young, Dirk] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Washington, DC 20460 USA. EM peck.charles@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 761-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101220 ER PT J AU Perera, L AF Perera, Lalith TI Metal ion binding at the active site of DNA plymerases SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Perera, Lalith] Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA. EM pereraL2@niehs.nih.gov NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 446-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165103869 ER PT J AU Perkins, EJ Habib, T Escalon, L Villenueve, DL Ankley, GT Garcia-Reyero, N AF Perkins, Edward J. Habib, Tanwir Escalon, Lynn Villenueve, Daniel L. Ankley, Gerald T. Garcia-Reyero, Natalia TI Inference of chemicals that cause biological effects in treated pulp and paper mill effluent using gene expression in caged fathead minnows SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Perkins, Edward J.; Escalon, Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Villenueve, Daniel L.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55802 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Gen Biocomp & Biotechnol 1Inst, Starkville, MS 39762 USA. EM edward.j.perkins@usace.army.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 7-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105452 ER PT J AU Postigo, C Richardson, SD Jeong, CH Wagner, ED Plewa, MJ Simmons, JE Barcelo, D AF Postigo, Cristina Richardson, Susan D. Jeong, Clara H. Wagner, Elizabeth D. Plewa, Michael J. Simmons, Jane Ellen Barcelo, Damia TI Occurrence and toxicity of haloaldehydes in drinking waters: Iodoacetaldehyde as an emerging disinfection byproduct SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Postigo, Cristina] IDAEA CSIC, Dept Environmetnal Chem, Inst Environm Assessment & Water Res, Barcelona 08034, Spain. [Richardson, Susan D.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Coll Agr Consumer & Environm Sci, Dept Crop Sci, Champaign, IL USA. [Simmons, Jane Ellen] US EPA, NHEERL, Pharmacokinet Branch, Integrated Syst Toxicol Div, Res Triangle Pk, NC USA. [Barcelo, Damia] Catalan Inst Water Res Res, Girona, Spain. EM cprqam@cid.csic.es RI Postigo, Cristina/H-7876-2015 OI Postigo, Cristina/0000-0002-7344-7044 NR 0 TC 0 Z9 0 U1 3 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 62-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105502 ER PT J AU Qian, YR AF Qian, Yaorong TI Screening for pesticides and their degradates in water and agricultural commodities using UPLC-MS/MS and GC-MS/MS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Qian, Yaorong] US EPA, Analyt Chem Branch, Ft George G Meade, MD 20755 USA. EM Qian.Yaorong@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 257-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100622 ER PT J AU Reynolds, A AF Reynolds, Alan TI Western corn rootworm resistance monitoring: Recommendations of the Scientific Advisory Panel SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Reynolds, Alan] US EPA, Biopesticides & Pollut Prevent Div, Washington, DC 20460 USA. EM reynolds.alan@epa.gov NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 619-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101084 ER PT J AU Rossi, LA AF Rossi, Lois A. TI US MRL global harmonization initiatives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Rossi, Lois A.] US EPA, Off Pesticide Programs, Registrat Div, Washington, DC 20460 USA. EM rossi.lois@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 394-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100756 ER PT J AU Ruhman, M Barrett, M Wente, S Parker, R Pluntke, K Bohaty, R Shamim, M AF Ruhman, Mohammed Barrett, Michael Wente, Stephen Parker, Ronald Pluntke, Kurt Bohaty, Rochelle Shamim, Mah TI Simplified approaches to exposure analysis of the total toxic residues of a pesticide in a regulatory setting SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Ruhman, Mohammed; Barrett, Michael; Wente, Stephen; Parker, Ronald; Pluntke, Kurt; Bohaty, Rochelle; Shamim, Mah] US EPA, Off Pesticide Programs, Washington, MD 20770 USA. EM ruhman.mohammed@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 993-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101442 ER PT J AU Ruiz-Mercado, G AF Ruiz-Mercado, Gerardo TI Using indicators to inform on sustainability SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Ruiz-Mercado, Gerardo] US EPA, Res & Dev, Cincinnati, OH 45268 USA. EM ruiz-mercado.gerardo@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 54-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400487 ER PT J AU Ruiz-Mercado, G AF Ruiz-Mercado, Gerardo TI Chemistry, chemical engineering, and sustainability SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Ruiz-Mercado, Gerardo] US EPA, Res & Dev, Cincinnati, OH 45268 USA. EM ruiz-mercado.gerardo@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 53-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400486 ER PT J AU Sahle-Demessie, E Mezgebe, B Sorial, G AF Sahle-Demessie, Endalkachew Mezgebe, Bineyam Sorial, George TI Biological treatment of water disinfection byproducts using biotrickling filter under anaerobic conditions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Mezgebe, Bineyam; Sorial, George] Univ Cincinnati, Dept Environm Engn, Cincinnati, OH 45222 USA. [Sahle-Demessie, Endalkachew] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM George.Sorial@uc.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 474-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106038 ER PT J AU Sahle-Demessie, E Zhao, A AF Sahle-Demessie, Endalkachew Zhao, Amy TI Environmental aging nanocomposites and release of nanoparticles SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Sahle-Demessie, Endalkachew; Zhao, Amy] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM sahle-demessie.endalkachew@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 30-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105474 ER PT J AU Schaefer, K Fitz, N Krebs, J AF Schaefer, Kristine Fitz, Nancy Krebs, Jerry TI Outreach activities of The Pesticide Stewardship Alliance (TPSA) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Schaefer, Kristine] Iowa State Univ, Dept Entomol, Ames, IA 50011 USA. [Fitz, Nancy] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. [Krebs, Jerry] TKI, Granite Bay, CA 95746 USA. EM jkrebs@tkinet.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 406-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100765 ER PT J AU Schroeder, A Ankley, G Berninger, J LaLone, C Cavallin, J Durhan, E Eid, E Garcia-Reyero, N Hughes, M Jensen, K Kahl, M Makynen, E Perkins, E Stevens, K Villeneuve, D AF Schroeder, Anthony Ankley, Gerald Berninger, Jason LaLone, Carlie Cavallin, Jenna Durhan, Elizabeth Eid, Evan Garcia-Reyero, Natalia Hughes, Megan Jensen, Kathy Kahl, Michael Makynen, Elizabeth Perkins, Ed Stevens, Kyle Villeneuve, Dan TI Integration of analytical and biological measurements for assessing the effects of contaminants present at Great Lakes areas of concern SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Schroeder, Anthony; LaLone, Carlie] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA. [Schroeder, Anthony; Ankley, Gerald; LaLone, Carlie; Durhan, Elizabeth; Eid, Evan; Hughes, Megan; Jensen, Kathy; Kahl, Michael; Makynen, Elizabeth; Villeneuve, Dan] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Perkins, Ed] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM schroeder.anthony@epa.gov RI Berninger, Jason/O-2401-2016 OI Berninger, Jason/0000-0003-3045-7899 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 668-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106211 ER PT J AU Shamim, MT Reuben, B Bireley, R Decant, J Farruggia, F Garber, K Hart, C Hou, W Sappington, K Steeger, T Vaughan, A Wendel, C AF Shamim, Mah T. Reuben, Baris Bireley, Richard Decant, Joseph Farruggia, Frank Garber, Kristina Hart, Connie Hou, Wayne Sappington, Keith Steeger, Thomas Vaughan, Allen Wendel, Christina TI Tiered risk assessment process to evaluate potential adverse effects to pollinating bees from exposure to pesticides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Shamim, Mah T.; Reuben, Baris; Decant, Joseph; Farruggia, Frank; Garber, Kristina; Sappington, Keith; Steeger, Thomas; Vaughan, Allen; Wendel, Christina] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Washington, DC 20460 USA. [Hart, Connie; Hou, Wayne] Hlth Canada Pest Management Regulatory Agcy, Environm Assessment Directorate, Ottawa, ON K1A0K9, Canada. [Bireley, Richard] Calif Environm Protect Agcy, Pesticide Programs Div, Dept Pesticide Regulat, Sacramento, CA 95812 USA. EM shamim.mah@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 608-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101074 ER PT J AU Shamim, MT Decant, J Sappington, K Vaughan, A AF Shamim, Mah T. Decant, Joseph Sappington, Keith Vaughan, Allen TI Open field feeding study design with Apis mellifera to evaluate the whole-hive toxicity of imidacloprid at multiple concentrations in sucrose solution SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Shamim, Mah T.; Decant, Joseph; Sappington, Keith; Vaughan, Allen] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Washington, DC 20460 USA. EM shamim.mah@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 607-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101073 ER PT J AU Shamim, MT Melendez, J Ruhman, M Sappington, K AF Shamim, Mah T. Melendez, Jose Ruhman, Mohammed Sappington, Keith TI Approaches to regulation of urban pesticide uses SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Shamim, Mah T.; Melendez, Jose; Ruhman, Mohammed; Sappington, Keith] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Washington, DC 20460 USA. EM shamim.mah@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 58-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100431 ER PT J AU Stiegel, MA Sobus, JR Madden, MC Pleil, JD AF Stiegel, Matthew A. Sobus, Jon R. Madden, Michael C. Pleil, Joachim D. TI Combining data visualization and statistical approaches for interpreting measurements and meta-data: Integrating heatmaps, variable clustering, and mixed regression models SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Stiegel, Matthew A.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Sobus, Jon R.; Madden, Michael C.; Pleil, Joachim D.] US EPA, Methods Dev & Applicat Branch, Res Triangle Pk, NC 27711 USA. EM mstiegel@live.unc.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 853-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400167 ER PT J AU Tettenhorst, DR Shoemaker, JA AF Tettenhorst, Daniel R. Shoemaker, Jody A. TI Development of a US EPA method for the analysis of select cyanotoxins in drinking water by solid phase extraction and LC/MS/MS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Tettenhorst, Daniel R.; Shoemaker, Jody A.] US EPA, Cincinnati, OH 45268 USA. EM tettenhorst.dan@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 557-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106115 ER PT J AU Ulrich, E McMillan, L Wang, QH Albertson, T Cho, G Kuivila, K Lao, WJ Peoples, S Lopez, RR TenBrook, P AF Ulrich, Elin McMillan, Larry Wang, Qianheng Albertson, Todd Cho, Gail Kuivila, Kathy Lao, Wenjian Peoples, Sue Lopez, Ruben Reif TenBrook, Patti TI Enantiomer specific measurements of current-use pesticides in aquatic systems SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Ulrich, Elin] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [McMillan, Larry] Natl Caucus & Ctr Black Aged, Durham, NC 27713 USA. [Wang, Qianheng] US EPA, Res Triangle Pk, NC 27711 USA. [Albertson, Todd] Caltest Analyt Lab, Napa, CA 94558 USA. [Cho, Gail] Calif Dept Fish & Wildlife, Rancho Cordova, CA 95670 USA. [Kuivila, Kathy] US Geol Survey, Portland, OR 97201 USA. [Lao, Wenjian] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Peoples, Sue] Calif Dept Pesticide Regulat, Sacramento, CA 95812 USA. [Lopez, Ruben Reif] Univ Calif Riverside, Riverside, CA 92521 USA. [TenBrook, Patti] US EPA, San Francisco, CA 94105 USA. EM ulrich.elin@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 644-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101107 ER PT J AU Vaddula, BR Yalla, S Gonzalez, MA AF Vaddula, Buchi R. Yalla, Swathi Gonzalez, Michael A. TI Multicomponent flow approach for the efficient and more sustainable preparation of aminothiazole derivatives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Vaddula, Buchi R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Yalla, Swathi; Gonzalez, Michael A.] US EPA, Natl Risk Management Lab, Cincinnati, OH 45268 USA. EM reddy.buchi@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 829-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400144 ER PT J AU Vaddula, BR Anderson, L Yalla, S Gonzalez, M AF Vaddula, Buchi Reddy Anderson, Laura Yalla, Swathi Gonzalez, Michael TI Rapid synthesis of a-hydroxy acids and N-alkyl amides in the continuous-flow spinning tube-in-tube ( STT r) reactor SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Gonzalez, Michael] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Vaddula, Buchi Reddy] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. EM reddy.buchi@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 863-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167403426 ER PT J AU Vaddula, BR Yalla, S Gonzalez, M AF Vaddula, Buchi Reddy Yalla, Swathi Gonzalez, Michael TI Efficient and more sustainable one-step continuous-flow multicomponent synthesis of chromene derivatives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Gonzalez, Michael] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45220 USA. [Vaddula, Buchi Reddy] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. EM reddy.buchi@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 164-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167402629 ER PT J AU Vaddula, BR Yalla, S Gonzalez, M AF Vaddula, Buchi Reddy Yalla, Swathi Gonzalez, Michael TI Rapid and benign approaches for addition and coupling reactions using flow chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Gonzalez, Michael] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Vaddula, Buchi Reddy] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. EM reddy.buchi@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 91-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400509 ER PT J AU Van Emon, JM AF Van Emon, Jeanette M. TI Omics revolution in agricultural research SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Van Emon, Jeanette M.] US EPA, Dept ORD HEASD MDAB, Las Vegas, NV 89119 USA. EM vanemon.jeanette@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 599-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165101065 ER PT J AU Varma, RS Gawande, MB Zboril, R AF Varma, Rajender S. Gawande, Manoj B. Zboril, Radek TI Sustainable catalytic transformations using magnetically retrievable nano-catalysts SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc ID MICROWAVE C1 [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Gawande, Manoj B.; Zboril, Radek] Palacky Univ, Reg Ctr Adv Technol & Mat, CR-77147 Olomouc, Czech Republic. EM Varma.Rajender@epa.gov RI Zboril, Radek/F-5153-2015 NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 870-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167400183 ER PT J AU Veronesi, B Han, C Pelaez, MA Choi, H Betancourt, D Dionysiou, DD AF Veronesi, Bellina Han, Changseok Pelaez, Miguel Angel Choi, Hyeok Betancourt, Doris Dionysiou, Dionysios D. TI Linking the physicochemical properties of modified titania with its biocidal properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Veronesi, Bellina] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Han, Changseok] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. [Pelaez, Miguel Angel; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45268 USA. [Choi, Hyeok] Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA. [Betancourt, Doris] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM veronesi.bellina@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 570-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106127 ER PT J AU Virkutyte, J Al-Abed, SR Zhang, ZY AF Virkutyte, Jurate Al-Abed, Souhail R. Zhang, Zhenyuan TI Nanosilver in socks: Antimicrobial activity and characterization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Virkutyte, Jurate; Zhang, Zhenyuan] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM zzhang1898@gmail.com NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 580-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106136 ER PT J AU Virkutyte, J Al-Abed, SR Choi, H Bennett-Stamper, C Zhang, ZY AF Virkutyte, Jurate Al-Abed, Souhail R. Choi, Hyeok Bennett-Stamper, Christina Zhang, Zhenyuan TI Distinct structural behavior and transport of TiO2 nano- and nanostructured particles in sand SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Virkutyte, Jurate; Zhang, Zhenyuan] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.; Bennett-Stamper, Christina] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Choi, Hyeok] Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA. EM zzhang1898@gmail.com NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 718-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165104241 ER PT J AU Wozniak, CA AF Wozniak, Chris A. TI Regulation of double-stranded RNA-based pesticides by the US Environmental Protection Agency SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Wozniak, Chris A.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. EM wozniak.chris@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 154-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165100522 ER PT J AU Zepp, RG Cyterski, M Kisselle, K Kozovits, AR Bustamante, MMC AF Zepp, Richard G. Cyterski, Mike Kisselle, Keith Kozovits, Alessandra R. Bustamante, Mercedes M. C. TI Photoproduction of carbon monoxide from natural organic matter SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Zepp, Richard G.; Cyterski, Mike] US EPA, NERL ERD, Athens, GA 30605 USA. [Kisselle, Keith] Austin Coll, Sherman, TX 75090 USA. [Kozovits, Alessandra R.] Univ Fed Ouro Preto, Ouro Preto, Brazil. [Bustamante, Mercedes M. C.] Univ Brasilia, Dept Ecol, Brasilia, DF, Brazil. EM zepp.richard@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 393-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105812 ER PT J AU Rotroff, DM Martin, MT Dix, DJ Filer, DL Houck, KA Knudsen, TB Sipes, NS Reif, DM Xia, MH Huang, RL Judson, RS AF Rotroff, Daniel M. Martin, Matt T. Dix, David J. Filer, Dayne L. Houck, Keith A. Knudsen, Thomas B. Sipes, Nisha S. Reif, David M. Xia, Menghang Huang, Ruili Judson, Richard S. TI Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MOLECULAR-MECHANISMS; BETA; DISRUPTORS; CANCER; CELLS; CHEMICALS; ALPHA; US AB Thousands of environmental chemicals are subject to regulatory review for their potential to be endocrine disruptors (ED). In vitro high-throughput screening (HTS) assays have emerged as a potential tool for prioritizing chemicals for ED-related whole-animal tests. In this study, 1814 chemicals including pesticide active and inert ingredients, industrial chemicals, food additives, and pharmaceuticals were evaluated in a panel of 13 in vitro HTS assays. The panel of in vitro assays interrogated multiple end points related to estrogen receptor (ER) signaling, namely binding, agonist, antagonist, and cell growth responses. The results from the in vitro assays were used to create an ER Interaction Score. For 36 reference chemicals, an ER Interaction Score >0 showed 100% sensitivity and 87.5% specificity for classifying potential ER activity. The magnitude of the ER Interaction Score was significantly related to the potency classification of the reference chemicals (p < 0.0001). ER alpha/ER beta selectivity was also evaluated, but relatively few chemicals showed significant selectivity for a specific isoform. When applied to a broader set of chemicals with in vivo uterotrophic data, the ER Interaction Scores showed 91% sensitivity and 65% specificity. Overall, this study provides a novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization. C1 [Rotroff, Daniel M.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA. [Rotroff, Daniel M.; Martin, Matt T.; Dix, David J.; Filer, Dayne L.; Houck, Keith A.; Knudsen, Thomas B.; Sipes, Nisha S.; Reif, David M.; Judson, Richard S.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Xia, Menghang; Huang, Ruili] NIH, Natl Ctr Adv Translat Sci, Bethesda, MD 20892 USA. RP Judson, RS (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA. EM judson.richard@epa.gov OI Judson, Richard/0000-0002-2348-9633; Reif, David/0000-0001-7815-6767 NR 32 TC 23 Z9 24 U1 9 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 5 PY 2014 VL 48 IS 15 SI SI BP 8706 EP 8716 DI 10.1021/es502676e PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AM7WY UT WOS:000340080600047 PM 24960280 ER PT J AU Kertesz, R Rhea, L Murray, DJ AF Kertesz, Ruben Rhea, Lee Murray, Daniel J., Jr. TI Spatial and temporal structure within moisture measurements of a stormwater control system SO JOURNAL OF HYDROLOGY LA English DT Article DE Pervious concrete; Soil; Sensor; Moisture; Stormwater; Infiltration ID TIME-DOMAIN REFLECTOMETRY; SOIL-WATER CONTENT; GROUNDWATER RECHARGE; GREEN ROOF; INFILTRATION; PERFORMANCE; SENSOR; RUNOFF; MEDIA AB This study develops novel geostatistical methods to investigate the spatial relationship between individual soil moisture sensors placed within native soil and #57 crushed stone aggregate subbase. The subbase sensors are beneath a 0.06 ha (0.15 acre) pervious concrete parking lot in Cincinnati, OH, USA. The parking lot treats runon from a 0.198 ha (0.49 acre) asphalt area. A geostatistical characterization of moisture (measured as permittivity) in the subbase beneath pervious concrete indicates that significant spatial correlation is either not present or only present at very short distances (<2.5 m). A two-stage para-statistical model relating antecedent storm moisture to apparent pervious concrete infiltration was developed to identify temporal trends in the data and to detect the clogging processes with relatively simple parameterization. The results suggest that either the placement of the sensors is not sufficient to detect clogging or that clogging is not problematic for the study period. Suggestions are provided to improve future research installations, based upon the findings here. Subbase moisture analysis results are compared with native soil moisture results. Seasonal trends are more pronounced in the native soil than in the subbase. The statistical analyses are applicable to multiple Storm Control Measures (SCM), Best Management Practices (BMP), agriculture, and soil environments. Other studies can determine the statistical power of their sensor installation using the methods applied here, which are flexible enough for multiple applications. Furthermore, data reduction methods presented serve to easily elucidate short-term moisture responses due to rainfall. A quantile response pattern is provided for sensors installed in both subbase and soil. Published by Elsevier B.V. C1 [Kertesz, Ruben; Rhea, Lee; Murray, Daniel J., Jr.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Kertesz, R (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM kertesz.ruben@epa.gov NR 33 TC 2 Z9 2 U1 2 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD AUG 4 PY 2014 VL 516 SI SI BP 222 EP 230 DI 10.1016/j.jhydrol.2014.02.011 PG 9 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AL3NT UT WOS:000339036100021 ER PT J AU Spokas, KA Novak, JM Masiello, CA Johnson, MG Colosky, EC Ippolito, JA Trigo, C AF Spokas, K. A. Novak, J. M. Masiello, C. A. Johnson, M. G. Colosky, E. C. Ippolito, J. A. Trigo, C. TI Physical Disintegration of Biochar: An Overlooked Process SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID DISSOLVED ORGANIC-MATTER; BLACK CARBON; SOIL; CHARCOAL; STABILITY; TRANSPORT; TRANSFORMATION; TEMPERATURE; PARTICLES; ULTISOLS AB Data collected from both artificially and field (naturally) weathered biochar suggest that a potentially significant pathway of biochar disappearance is through physical breakdown of the biochar structure. Via scanning electron microscopy, we characterized this physical weathering that increased the number of structural fractures and yielded higher numbers of liberated biochar fragments. This was hypothesized to be due to the graphitic sheet expansion accompanying water sorption coupled with comminution. These fragments can be on the microscale and the nanoscale but are still carbon-rich particles with no detectable alteration in the oxygen:carbon ratio from that of the original biochar. However, these particles are now easily dissolved and could be moved by infiltration. There is a need to understand how to produce biochars that are resistant to physical degradation to maximize long-term biochar C sequestration potential within soil systems. C1 [Spokas, K. A.] ARS, USDA, St Paul, MN 55018 USA. [Spokas, K. A.; Colosky, E. C.; Trigo, C.] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA. [Novak, J. M.] ARS, USDA, Florence, SC 29501 USA. [Masiello, C. A.] Rice Univ, Dept Earth Sci, Houston, TX 77005 USA. [Masiello, C. A.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Johnson, M. G.] US EPA, Corvallis, OR 97333 USA. [Ippolito, J. A.] ARS, USDA, Kimberly, ID 83341 USA. RP Spokas, KA (reprint author), USDA ARS, 1991 Upper Buford Circle,439 Borlaug Hall, St Paul, MN 55108 USA. EM kurt.spokas@ars.usda.gov RI Masiello, Caroline/A-2653-2011; Spokas, Kurt/F-4839-2016 OI Masiello, Caroline/0000-0003-2102-6229; Spokas, Kurt/0000-0002-5049-5959 FU U.S. Environmental Protection Agency; Agricultural Research Service of the U.S. Department of Agriculture; National Science Foundation through the Materials Research Science and Engineering Centers program; Minnesota Corn Growers Association/Minnesota Corn Research Production Council; Minnesota Agricultural Utilization Research Institute FX This work has been funded in part by the U.S. Environmental Protection Agency and the Agricultural Research Service of the U.S. Department of Agriculture. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agencies, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. We acknowledge the exceptional laboratory work conducted by Martin DuSaire, Eric Nooker, Laura Colosky, Lee Yang, and Rena Weis. Parts of this work were conducted in the Characterization Facility of the University of Minnesota, which receives partial support from National Science Foundation through the Materials Research Science and Engineering Centers program. In addition, we acknowledge the partial funding from the Minnesota Corn Growers Association/Minnesota Corn Research Production Council and the Minnesota Agricultural Utilization Research Institute. This research is part of the USDA-ARS Biochar and Pyrolysis Initiative and USDA-ARS GRACEnet (Greenhouse Gas Reduction through Agricultural Carbon Enhancement Network) programs. We also greatly appreciate the comments from two anonymous reviewers that improved the clarity and impact of this work. NR 45 TC 23 Z9 25 U1 14 U2 66 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD AUG PY 2014 VL 1 IS 8 BP 326 EP 332 DI 10.1021/ez500199t PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CD1JO UT WOS:000350831400002 ER PT J AU Fent, KW Eisenberg, J Snawder, J Sammons, D Pleil, JD Stiegel, MA Mueller, C Horn, GP Dalton, J AF Fent, Kenneth W. Eisenberg, Judith Snawder, John Sammons, Deborah Pleil, Joachim D. Stiegel, Matthew A. Mueller, Charles Horn, Gavin P. Dalton, James TI Systemic Exposure to PAHs and Benzene in Firefighters Suppressing Controlled Structure Fires SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Article DE aromatic hydrocarbons; benzene; biomarkers; dermal exposure; exhaled breath; firefighters; PAHs; urine ID POLYCYCLIC AROMATIC-HYDROCARBONS; ASPHALT PAVING WORKERS; ENVIRONMENTAL EXPOSURE; DERMAL EXPOSURE; CANCER-RISK; ABSORPTION; BREATH; BIOMARKERS; PENETRATION; EXHAUST AB Turnout gear provides protection against dermal exposure to contaminants during firefighting; however, the level of protection is unknown. We explored the dermal contribution to the systemic dose of polycyclic aromatic hydrocarbons (PAHs) and other aromatic hydrocarbons in firefighters during suppression and overhaul of controlled structure burns. The study was organized into two rounds, three controlled burns per round, and five firefighters per burn. The firefighters wore new or laundered turnout gear tested before each burn to ensure lack of PAH contamination. To ensure that any increase in systemic PAH levels after the burn was the result of dermal rather than inhalation exposure, the firefighters did not remove their self-contained breathing apparatus until overhaul was completed and they were > 30 m upwind from the burn structure. Specimens were collected before and at intervals after the burn for biomarker analysis. Urine was analyzed for phenanthrene equivalents using enzyme-linked immunosorbent assay and a benzene metabolite (s-phenylmercapturic acid) using liquid chromatography/tandem mass spectrometry; both were adjusted by creatinine. Exhaled breath collected on thermal desorption tubes was analyzed for PAHs and other aromatic hydrocarbons using gas chromatography/mass spectrometry. We collected personal air samples during the burn and skin wipe samples (corn oil medium) on several body sites before and after the burn. The air and wipe samples were analyzed for PAHs using a liquid chromatography with photodiode array detection. We explored possible changes in external exposures or biomarkers over time and the relationships between these variables using non-parametric sign tests and Spearman tests, respectively. We found significantly elevated (P < 0.05) post-exposure breath concentrations of benzene compared with pre-exposure concentrations for both rounds. We also found significantly elevated post-exposure levels of PAHs on the neck compared with pre-exposure levels for round 1. We found statistically significant positive correlations between external exposures (i.e. personal air concentrations of PAHs) and biomarkers (i.e. change in urinary PAH metabolite levels in round 1 and change in breath concentrations of benzene in round 2). The results suggest that firefighters wearing full protective ensembles absorbed combustion products into their bodies. The PAHs most likely entered firefighters' bodies through their skin, with the neck being the primary site of exposure and absorption due to the lower level of dermal protection afforded by hoods. Aromatic hydrocarbons could have been absorbed dermally during firefighting or inhaled during the doffing of gear that was off-gassing contaminants. C1 [Fent, Kenneth W.; Eisenberg, Judith; Mueller, Charles] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Snawder, John; Sammons, Deborah] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Pleil, Joachim D.] US Environm Protect Agcy, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27709 USA. [Stiegel, Matthew A.] Gillings Sch Global Publ, Oak Ridge Inst Sci & Educ, Chapel Hill, NC 27599 USA. [Horn, Gavin P.] Univ Illinois, Illinois Fire Serv Inst, Champaign, IL 61820 USA. [Dalton, James] Chicago Fire Dept, Training Div, Res & Dev Sect, Chicago, IL 60607 USA. RP Fent, KW (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM kfent@cdc.gov OI Pleil, Joachim/0000-0001-8211-0796 FU National Institute for Occupational Safety and Health (NIOSH) by National Occupational Research Agenda; NIOSH Human Subjects Review Board FX National Institute for Occupational Safety and Health (NIOSH) by intramural award under the National Occupational Research Agenda; NIOSH Human Subjects Review Board. NR 48 TC 10 Z9 11 U1 5 U2 35 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 EI 1475-3162 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD AUG PY 2014 VL 58 IS 7 BP 830 EP 845 DI 10.1093/annhyg/meu036 PG 16 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA AS4IY UT WOS:000344239400004 PM 24906357 ER PT J AU Krewski, D Westphal, M Andersen, ME Paoli, GM Chiu, WA Al-Zoughool, M Croteau, MC Burgoon, LD Cote, I AF Krewski, Daniel Westphal, Margit Andersen, Melvin E. Paoli, Gregory M. Chiu, Weihsueh A. Al-Zoughool, Mustafa Croteau, Maxine C. Burgoon, Lyle D. Cote, Ila TI A Framework for the Next Generation of Risk Science SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID THROUGHPUT SCREENING DATA; POPULATION HEALTH-RISKS; POINT-OF-DEPARTURE; IN-VIVO HAZARD; ENVIRONMENTAL CHEMICALS; PUBLIC PERCEPTION; OIL-SPILL; TOXICITY; VITRO; 21ST-CENTURY AB OBJECTIVES: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. METHODS: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. RESULTS: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. CONCLUSIONS: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. C1 [Krewski, Daniel; Westphal, Margit; Al-Zoughool, Mustafa; Croteau, Maxine C.] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada. [Krewski, Daniel; Paoli, Gregory M.] Risk Sci Int, Ottawa, ON, Canada. [Andersen, Melvin E.] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC USA. [Chiu, Weihsueh A.; Burgoon, Lyle D.; Cote, Ila] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Westphal, M (reprint author), McLaughlin Ctr Populat Hlth Risk Assessment, 1 Stewart St,Suite 318, Ottawa, ON K1N 6N5, Canada. EM mgeister@uottawa.ca OI Burgoon, Lyle/0000-0003-4977-5352 FU ICF International; U.S. EPA; Long-Range Research Initiative of the American Chemical Council FX D.K. holds the Natural Sciences and Engineering Research Council of Canada Chair in Risk Science at the University of Ottawa. D.K. and G.M.P. are principle risk scientists at Risk Sciences International (RSI), a Canadian company established in 2006 in partnership with the University of Ottawa. RSI's contribution to this work was funded through a subcontract with ICF International, which held the primary contract with the U.S. EPA to develop the NexGen framework. Although this work was initiated by the U.S. EPA, the NexGen project was conducted in partnership with the following agencies: the Army Corps of Engineers; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency; National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention; Office of the Secretary of Defense, Department of Defense; European Chemicals Agency; European Joint Research Commission; National Center for Toxicological Research, Food and Drug Administration; Healthy Environments and Consumer Safety Branch, Health Canada; National Center for Advancing Translational Science, National Cancer Institute, National Institute of Environmental Health Sciences, and National Toxicology Program, National Institutes of Health; and the National Institute for Occupational Safety and Health. The project also involved extensive consultation with multiple other public, private, and academic groups and individuals.; M.E.A. received support from the Long-Range Research Initiative of the American Chemical Council. The other authors declare they have no actual or potential competing financial interests. NR 83 TC 22 Z9 23 U1 5 U2 54 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD AUG PY 2014 VL 122 IS 8 BP 796 EP 805 DI 10.1289/ehp.1307260 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AO9XL UT WOS:000341713800013 PM 24727499 ER PT J AU Rubin, SSCD Alava, P Zekker, I Du Laing, G Van de Wiele, T AF Rubin, Sergio S. C. Dc. Alava, Pradeep Zekker, Ivar Du Laing, Gijs Van de Wiele, Tom TI Arsenic Thiolation and the Role of Sulfate-Reducing Bacteria from the Human Intestinal Tract SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID HUMAN GUT MICROBIOTA; HPLC-ICP-MS; IN-VITRO; METABOLISM; ACID; SPECIATION; URINE; POPULATIONS; DIVERSITY AB BACKGROUND: Arsenic (As) toxicity is primarily based on its chemical speciation. Although inorganic and methylated As species are well characterized in terms of metabolism and formation in the human body, the origin of thiolated methylarsenicals is still unclear. OBJECTIVES: We sought to determine whether sulfate--reducing bacteria (SRB) from the human gut are actively involved in the thiolation of monomethylarsonic acid (MMA(V)). METHODS: We incubated human fecal and colon microbiota in a batch incubator and in a dynamic gut simulator with a dose of 0.5 mg MMA(V) in the absence or presence of sodium molybdate, an SRB inhibitor. We monitored the conversion of MMAV into monomethyl monothioarsonate (MMMTA(V)) and other As species by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry analysis. We monitored the sulfate-reducing activity of the SRB by measuring hydrogen sulfide (H2S) production. We used molecular analysis to determine the dominant species of SRB responsible for As thiolation. RESULTS: In the absence of sodium molybdate, the SRB activity-primarily derived from Desulfovibrio desulfuricans (piger)-was specifically and proportionally correlated (p < 0.01) to MMA(V) conversion into MMMTA(V). Inactivating the SRB with molybdate did not result in MMA(V) thiolation; however, we observed that the microbiota from a dynamic gut simulator were capable of demethylating 4% of the incubated MMA(V) into arsenous acid (iAs(III)), the trivalent and more toxic form of arsenic acid (iAs(V)). CONCLUSION: We found that SRB of human gastrointestinal origin, through their ability to produce H2S, were necessary and sufficient to induce As thiolation. The toxicological consequences of this microbial As speciation change are not yet clear. However, given the efficient epithelial absorption of thiolated methylarsenicals, we conclude that the gut microbiome-and SRB activity in particular-should be incorporated into toxicokinetic analysis carried out after As exposure. C1 [Rubin, Sergio S. C. Dc.; Van de Wiele, Tom] Univ Ghent, Fac Bioingn Wetenschappen, Lab Microbiele Ecol & Technol, B-9000 Ghent, Belgium. [Rubin, Sergio S. C. Dc.] Ctr Nacl Invest Biotecnol, Cochabamba, Bolivia. [Alava, Pradeep] US EPA, Res Triangle Pk, NC 27711 USA. [Zekker, Ivar] Univ Tartu, Inst Chem, EE-50090 Tartu, Estonia. [Du Laing, Gijs] Univ Ghent, Lab Analyt & Appl Ecochem, B-9000 Ghent, Belgium. RP Rubin, SSCD (reprint author), Univ Ghent, Fac Bioingn Wetenschappen, Lab Microbiele Ecol & Technol, Coupure Links 653, B-9000 Ghent, Belgium. EM sergio.rubin@ugent.be; tom.vandewiele@ugent.be FU De Vlaamse Interuniversitaire Raad (VLIR), Belgium; European Commission; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil; Estonian Ministry of Education and Science [IUT20-16]; Belgian federal government [BIOTRAS RF 6247] FX S.S.C. DC. R. received fellowships from the De Vlaamse Interuniversitaire Raad (VLIR), Belgium, and the Erasmus Mundus Program from the European Commission and is currently a postdoc fellow of the Science Without Borders Program, from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil. I.Z. received support from the Estonian Ministry of Education and Science Project IUT20-16. This work was supported by grant BIOTRAS RF 6247 from the Belgian federal government. NR 39 TC 13 Z9 13 U1 9 U2 67 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD AUG PY 2014 VL 122 IS 8 BP 817 EP 822 DI 10.1289/ehp.1307759 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AO9XL UT WOS:000341713800016 ER PT J AU Stingone, JA Luben, TJ Daniels, JL Fuentes, M Richardson, DB Aylsworth, AS Herring, AH Anderka, M Botto, L Correa, A Gilboa, SM Langlois, PH Mosley, B Shaw, GM Siffel, C Olshan, AF AF Stingone, Jeanette A. Luben, Thomas J. Daniels, Julie L. Fuentes, Montserrat Richardson, David B. Aylsworth, Arthur S. Herring, Amy H. Anderka, Marlene Botto, Lorenzo Correa, Adolfo Gilboa, Suzanne M. Langlois, Peter H. Mosley, Bridget Shaw, Gary M. Siffel, Csaba Olshan, Andrew F. CA Natl Birth Defects Prevention Stud TI Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID POLLUTION; ANOMALIES; PREGNANCY; RISK; MALFORMATIONS; CALIFORNIA; DISEASE AB Background: Epidemiologic literature suggests that exposure to air pollutants is associated with fetal development. Objectives: We investigated maternal exposures to air pollutants during weeks 2-8 of pregnancy and their associations with congenital heart defects. Methods: Mothers from the National Birth Defects Prevention Study, a nine-state case-control study, were assigned 1-week and 7-week averages of daily maximum concentrations of carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide and 24-hr measurements of fine and coarse particulate matter using the closest air monitor within 50 km to their residence during early pregnancy. Depending on the pollutant, a maximum of 4,632 live-birth controls and 3,328 live-birth, fetal-death, or electively terminated cases had exposure data. Hierarchical regression models, adjusted for maternal demographics and tobacco and alcohol use, were constructed. Principal component analysis was used to assess these relationships in a multipollutant context. Results: Positive associations were observed between exposure to nitrogen dioxide and coarctation of the aorta and pulmonary valve stenosis. Exposure to fine particulate matter was positively associated with hypoplastic left heart syndrome but inversely associated with atrial septal defects. Examining individual exposure-weeks suggested associations between pollutants and defects that were not observed using the 7-week average. Associations between left ventricular outflow tract obstructions and nitrogen dioxide and between hypoplastic left heart syndrome and particulate matter were supported by findings from the multipollutant analyses, although estimates were attenuated at the highest exposure levels. Conclusions: Using daily maximum pollutant levels and exploring individual exposure-weeks revealed some positive associations between certain pollutants and defects and suggested potential windows of susceptibility during pregnancy. C1 [Stingone, Jeanette A.; Daniels, Julie L.; Richardson, David B.; Olshan, Andrew F.] UNC Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Luben, Thomas J.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Fuentes, Montserrat] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA. [Aylsworth, Arthur S.] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA. [Aylsworth, Arthur S.] Univ N Carolina, Dept Pediat Genet, Chapel Hill, NC USA. [Herring, Amy H.] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Anderka, Marlene] Massachusetts Dept Publ Hlth, Massachusetts Ctr Birth Defects Res & Prevent, Boston, MA USA. [Botto, Lorenzo] Univ Utah, Dept Genet & Pediat, Salt Lake City, UT USA. [Correa, Adolfo] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA. [Gilboa, Suzanne M.; Siffel, Csaba] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Langlois, Peter H.] Texas Dept State Hlth Serv, Texas Ctr Birth Defects Res & Prevent, Austin, TX USA. [Mosley, Bridget] Univ Arkansas Med Sci, Arkansas Ctr Birth Defects Res & Prevent, Little Rock, AR 72205 USA. [Shaw, Gary M.] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA. RP Stingone, JA (reprint author), Icahn Sch Med Mt Sinai, Dept Prevent Med, Box 1057,17 East 102nd St,2nd Floor 2 West, New York, NY 10029 USA. EM jeanette.stingone@mssm.edu FU Centers for Disease Control and Prevention in National Birth Defects Prevention Study [U50CCU422096]; National Institute of Environmental Health Sciences [P30ES010126, T32ES007018]; Eunice Kennedy Shriver National Institute of Child Health and Development [T32HD052468] FX This study was supported in part through cooperative agreements under Program Announcement 02081 from the Centers for Disease Control and Prevention to the centers participating in the National Birth Defects Prevention Study including cooperative agreement U50CCU422096. Additionally, this research was supported in part by grants from the National Institute of Environmental Health Sciences (P30ES010126 and T32ES007018) and by the Eunice Kennedy Shriver National Institute of Child Health and Development (T32HD052468). NR 33 TC 19 Z9 21 U1 2 U2 24 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD AUG PY 2014 VL 122 IS 8 BP 863 EP 872 DI 10.1289/ehp.1307289 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AO9XL UT WOS:000341713800024 PM 24727555 ER PT J AU Weaver, CP Mooney, S Allen, D Beller-Simms, N Fish, T Grambsch, AE Hohenstein, W Jacobs, K Kenney, MA Lane, MA Langner, L Larson, E McGinnis, DL Moss, RH Nichols, LG Nierenberg, C Seyller, EA Stern, PC Winthrop, R AF Weaver, C. P. Mooney, S. Allen, D. Beller-Simms, N. Fish, T. Grambsch, A. E. Hohenstein, W. Jacobs, K. Kenney, M. A. Lane, M. A. Langner, L. Larson, E. McGinnis, D. L. Moss, R. H. Nichols, L. G. Nierenberg, C. Seyller, E. A. Stern, P. C. Winthrop, R. TI From global change science to action with social sciences SO NATURE CLIMATE CHANGE LA English DT Editorial Material ID CLIMATE ADAPTATION C1 [Weaver, C. P.; Grambsch, A. E.] US EPA, Washington, DC 20460 USA. [Mooney, S.] Boise State Univ, Dept Econ, Boise, ID 83725 USA. [Mooney, S.] Natl Sci Fdn, Expt Program Stimulate Competit Res, Arlington, VA 22230 USA. [Allen, D.; Seyller, E. A.] US Global Change Res Program, Washington, DC 20006 USA. [Beller-Simms, N.; Nierenberg, C.] NOAA, Silver Spring, MD 20910 USA. [Fish, T.] US Dept Interior, Washington, DC 20240 USA. [Hohenstein, W.] USDA, Washington, DC 20250 USA. [Jacobs, K.] Univ Arizona, Ctr Climate Adaptat Sci & Solut, Tucson, AZ 85721 USA. [Jacobs, K.] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA. [Kenney, M. A.] Univ Maryland, Cooperat Inst Climate & Satellites Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA. [Lane, M. A.; Stern, P. C.] CNR, Board Environm Change & Soc, Washington, DC 20001 USA. [Langner, L.] US Forest Serv, USDA, Washington, DC 20250 USA. [Larson, E.] NASA, Washington, DC 20546 USA. [McGinnis, D. L.] Montana State Univ, Billings, MT 59101 USA. [Moss, R. H.] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA. [Moss, R. H.] Univ Maryland, College Pk, MD 20740 USA. [Nichols, L. G.] Natl Sci Fdn, Div Behav & Cognit Sci, Arlington, VA 22230 USA. [Winthrop, R.] Bureau Land Management, Washington, DC 20003 USA. RP Weaver, CP (reprint author), US EPA, 1200 Penn Ave NW, Washington, DC 20460 USA. EM weaver.chris@epa.gov RI Weaver, Christopher/G-3714-2010 OI Weaver, Christopher/0000-0003-4016-5451 NR 22 TC 30 Z9 30 U1 1 U2 27 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD AUG PY 2014 VL 4 IS 8 BP 656 EP 659 PG 4 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AO7YF UT WOS:000341568200010 ER PT J AU Dawson, J AF Dawson, John TI ATMOSPHERIC SCIENCE Quiet weather, polluted air SO NATURE CLIMATE CHANGE LA English DT Editorial Material ID CLIMATE-CHANGE; UNITED-STATES; REGIONAL CLIMATE; SENSITIVITY; QUALITY C1 US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Dawson, J (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA. EM dawsonjp@gmail.com NR 8 TC 3 Z9 3 U1 3 U2 12 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD AUG PY 2014 VL 4 IS 8 BP 664 EP 665 PG 3 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AO7YF UT WOS:000341568200013 ER PT J AU Gordon, CJ Aydin, C Repasky, EA Kokolus, KM Dheyongera, G Johnstone, AFM AF Gordon, Christopher J. Aydin, Cenk Repasky, Elizabeth A. Kokolus, Kathleen M. Dheyongera, Geoffrey Johnstone, Andrew F. M. TI Behaviorally mediated, warm adaptation: A physiological strategy when mice behaviorally thermoregulate SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Behavioral thermoregulation; Ambient temperature; Development; Growth; Liver; Kidney; Tail ID ENVIRONMENTAL-TEMPERATURE; CARTILAGE GROWTH; MOUSE; RESPONSES; BODY; RATS AB Laboratory mice housed under standard vivarium conditions with an ambient temperature (T-a) of similar to 22 degrees C are likely to be cold stressed because this T-a is below their thermoneutral zone (TNZ). Mice raised at T(a)s within the TNZ adapt to the warmer temperatures, developing smaller internal organs and longer tails compared to mice raised at 22 degrees C. Since mice prefer T(a)s equal to their TNZ when housed in a thermocline, we hypothesized that mice reared for long periods (e.g., months) in a thermocline would undergo significant changes in organ development and tail length as a result of their thermoregulatory behavior. Groups of three female BALB/c mice at an age of 37 days were housed together in a thermocline consisting of a 90 cm long aluminum runway with a floor temperature ranging from 23 to 39 degrees C. Two side-by-side thermoclines allowed for a total of 6 mice to be tested simultaneously. Control mice were tested in isothermal runways maintained at a T-a of 22 degrees C. All groups were given cotton pads for bedding/nest building. Mass of heart, lung, liver, kidney, brain, and tail length were assessed after 73 days of treatment. Mice in the thermocline and control (isothermal) runways were compared to cage control mice housed 3/cage with bedding under standard vivarium conditions. Mice in the thermocline generally remained in the warm end throughout the daytime with little evidence of nest building, suggesting a state of thermal comfort. Mice in the isothermal runway built elaborate nests and huddled together in the daytime. Mice housed in the thermocline had significantly smaller livers and kidneys and an increase in tail length compared to mice in the isothermal runway as well as when compared to the cage controls. These patterns of organ growth and tail length of mice in the thermocline are akin to warm adaptation. Thus, thermoregulatory behavior altered organ development, a process we term behaviorally mediated, warm adaptation. Moreover, the data suggest that the standard vivarium conditions are likely a cold stress that alters normal organ development relative to mice allowed to select their thermal preferendum. Published by Elsevier Ltd. C1 [Gordon, Christopher J.; Johnstone, Andrew F. M.] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. [Aydin, Cenk] Uludag Univ, Fac Vet Med, Dept Physiol, TR-16059 Bursa, Turkey. [Repasky, Elizabeth A.; Kokolus, Kathleen M.] Roswell Canc Inst, Buffalo, NY USA. [Dheyongera, Geoffrey] Jagiellonian Univ Krakow, Inst Environm Sci, Krakow, Poland. RP Gordon, CJ (reprint author), US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov OI Kokolus, Kathleen/0000-0002-9088-5409 FU Foundation for Polish Science [MPD/2009-3/5/stp]; European Union FX We thank Mr. Earl Puckett for constructing the thermocline system. We thank Drs. A. Rezvani, D. Kurtz, and B. Gaskill for their review of the manuscript. We recognize the Foundation for Polish Science in collaboration with the European Union for financial support to Geoffrey Dheyongera's stay as a research scholar at US EPA under grant no. MPD/2009-3/5/stp in the international programme, "Environmental Stress, Population Viability and Adaptations". NR 14 TC 4 Z9 4 U1 3 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 2014 VL 44 BP 41 EP 46 DI 10.1016/j.jtherbio.2014.06.006 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA AO6QZ UT WOS:000341477900007 PM 25086972 ER PT J AU Wickham, J Homer, C Vogelmann, J McKerrow, A Mueller, R Herold, N Coulston, J AF Wickham, James Homer, Collin Vogelmann, James McKerrow, Alexa Mueller, Rick Herold, Nate Coulston, John TI The Multi-Resolution Land Characteristics (MRLC) Consortium-20 Years of Development and Integration of USA National Land Cover Data SO REMOTE SENSING LA English DT Article DE C-CAP; change detection; Cropland Data Layer (CDL); GAP; LANDFIRE; NLCD ID CONTERMINOUS UNITED-STATES; THEMATIC ACCURACY; IMPERVIOUS SURFACE; NLCD 2001; ANCILLARY DATA; PERCENT TREE; IMAGERY; COMPLETION; EMERGENCE; CANOPY AB The Multi-Resolution Land Characteristics (MRLC) Consortium demonstrates the national benefits of USA Federal collaboration. Starting in the mid-1990s as a small group with the straightforward goal of compiling a comprehensive national Landsat dataset that could be used to meet agencies' needs, MRLC has grown into a group of 10 USA Federal Agencies that coordinate the production of five different products, including the National Land Cover Database (NLCD), the Coastal Change Analysis Program (C-CAP), the Cropland Data Layer (CDL), the Gap Analysis Program (GAP), and the Landscape Fire and Resource Management Planning Tools (LANDFIRE). As a set, the products include almost every aspect of land cover from impervious surface to detailed crop and vegetation types to fire fuel classes. Some products can be used for land cover change assessments because they cover multiple time periods. The MRLC Consortium has become a collaborative forum, where members share research, methodological approaches, and data to produce products using established protocols, and we believe it is a model for the production of integrated land cover products at national to continental scales. We provide a brief overview of each of the main products produced by MRLC and examples of how each product has been used. We follow that with a discussion of the impact of the MRLC program and a brief overview of future plans. C1 [Wickham, James] USA Environm Protect Agcy, Natl Exposure Res Lab E243 05, Res Triangle Pk, NC 27711 USA. [Homer, Collin; Vogelmann, James] USA Geol Survey, Earth Resources Observat & Sci EROS Ctr, Sioux Falls, SD 57198 USA. [McKerrow, Alexa] N Carolina State Univ, USA Geol Survey, Raleigh, NC 27695 USA. [Mueller, Rick] USA Dept Agr, Natl Agr Stat Serv, Fairfax, VA 22030 USA. [Herold, Nate] NOAA, Coastal Serv Ctr, Charleston, SC 29405 USA. [Coulston, John] USDA Forest Serv, Southern Res Stn, Knoxville, TN 37919 USA. RP Wickham, J (reprint author), USA Environm Protect Agcy, Natl Exposure Res Lab E243 05, Res Triangle Pk, NC 27711 USA. EM wickham.james@epa.gov; homer@usgs.gov; vogel@usgs.gov; alexa_mckerrow@ncsu.edu; rick_mueller@nass.usda.gov; nate.herold@noaa.gov; jcoulston@fs.fed.us OI Vogelmann, James/0000-0002-0804-5823 FU The USA Environmental Protection Agency through its Office of Research and Development FX The USA Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here. It has been subjected to agency review and approved for publication. Approval does not signify that the contents reflect the views of the Agency. We thank Jeffery Eidenshink and Don Ohlen of the USGS and five anonymous journal reviewers for the helpful comments on earlier versions of the paper. NR 62 TC 5 Z9 6 U1 5 U2 21 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-4292 J9 REMOTE SENS-BASEL JI Remote Sens. PD AUG PY 2014 VL 6 IS 8 BP 7424 EP 7441 DI 10.3390/rs6087424 PG 18 WC Remote Sensing SC Remote Sensing GA AO7FV UT WOS:000341518700029 ER PT J AU Martin, SA Oshiro, WM Evansky, PA Degn, LL Ledbetter, AD Ford, J Krantz, QT LeFew, WR Beasley, TE El-Masri, H McLanahan, ED Boyes, WK Bushnell, PJ AF Martin, Sheppard A. Oshiro, Wendy M. Evansky, Paul A. Degn, Laura L. Ledbetter, Allen D. Ford, Jermaine Krantz, Q. Todd LeFew, William R. Beasley, Tracey E. El-Masri, Hisham McLanahan, Eva D. Boyes, William K. Bushnell, Philip J. TI Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats SO INHALATION TOXICOLOGY LA English DT Article DE Ethanol; physiologically-based pharmacokinetic (PBPK) models; pregnancy; rats ID BLOOD-ALCOHOL CONCENTRATIONS; VITREOUS-HUMOR; F344 RATS; RESPIRATORY DEPRESSION; NONINVASIVE ESTIMATION; ACETALDEHYDE FORMATION; POSTMORTEM BLOOD; EXPOSURE TUBES; OPTIC-NERVE; METABOLISM AB Ethanol (EtOH) exposure induces a variety of concentration-dependent neurological and developmental effects in the rat. Physiologically-based pharmacokinetic (PBPK) models have been used to predict the inhalation exposure concentrations necessary to produce blood EtOH concentrations (BEC) in the range associated with these effects. Previous laboratory reports often lacked sufficient detail to adequately simulate reported exposure scenarios associated with BECs in this range, or lacked data on the time-course of EtOH in target tissues (e. g. brain, liver, eye, fetus). To address these data gaps, inhalation studies were performed at 5000, 10 000, and 21 000ppm (6 h/d) in non-pregnant female Long-Evans (LE) rats and at 21 000 ppm (6.33 h/d) for 12 d of gestation in pregnant LE rats to evaluate our previously published PBPK models at toxicologically-relevant blood and tissue concentrations. Additionally, nose-only and whole-body plethysmography studies were conducted to refine model descriptions of respiration and uptake within the respiratory tract. The resulting time-course and plethysmography data from these in vivo studies were compared to simulations from our previously published models, after which the models were recalibrated to improve descriptions of tissue dosimetry by accounting for dose-dependencies in pharmacokinetic behavior. Simulations using the recalibrated models reproduced these data from non-pregnant, pregnant, and fetal rats to within a factor of 2 or better across datasets, resulting in a suite of model structures suitable for simulation of a broad range of EtOH exposure scenarios. C1 [Martin, Sheppard A.; Oshiro, Wendy M.; Degn, Laura L.; Beasley, Tracey E.; Boyes, William K.; Bushnell, Philip J.] US EPA, Off Res & Dev, Neurotoxicol Branch, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. [Evansky, Paul A.; Ledbetter, Allen D.; Krantz, Q. Todd] US EPA, Off Res & Dev, Environm Publ Hlth Div, Inhalat Facil Branch, Res Triangle Pk, NC 27711 USA. [Ford, Jermaine] US EPA, Off Res & Dev, Analyt Chem Res Core, Res Cores Unit, Res Triangle Pk, NC 27711 USA. [LeFew, William R.; El-Masri, Hisham] US EPA, Off Res & Dev, Integrated Syst Toxicol Div, Syst Biol Branch, Res Triangle Pk, NC 27711 USA. [McLanahan, Eva D.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. RP Martin, SA (reprint author), Procter & Gamble Co, 11530 Reed Hartman Highway, Cincinnati, OH 45241 USA. EM sam506@gmail.com FU Environmental Protection Agency through USEPA [EP-C-09-006] FX The information in this document has been funded by the Environmental Protection Agency, in part through USEPA contract EP-C-09-006. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval doses not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The authors have no conflicts of interest to report. NR 67 TC 6 Z9 6 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD AUG PY 2014 VL 26 IS 10 BP 598 EP 619 DI 10.3109/08958378.2014.938184 PG 22 WC Toxicology SC Toxicology GA AN8YJ UT WOS:000340891700003 PM 25144475 ER PT J AU Kochukov, MY Balasubramanian, A Abramowitz, J Birnbaumer, L Marrelli, SP AF Kochukov, Mikhail Y. Balasubramanian, Adithya Abramowitz, Joel Birnbaumer, Lutz Marrelli, Sean P. TI Activation of Endothelial Transient Receptor Potential C3 Channel Is Required for Small Conductance Calcium-Activated Potassium Channel Activation and Sustained Endothelial Hyperpolarization and Vasodilation of Cerebral Artery SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE cerebrovascular circulation; endothelium; endothelium-derived factors; ion channels; vasculature ID CA2+-ACTIVATED K+ CHANNELS; BRADYKININ-INDUCED VASODILATION; FACTOR-MEDIATED DILATIONS; TRPC3 CHANNELS; IKCA CHANNELS; RESISTANCE ARTERIES; PLASMA-MEMBRANE; COLLECTING DUCT; BLOOD-FLOW; IN-VIVO AB Background-Transient receptor potential C3 (TRPC3) has been demonstrated to be involved in the regulation of vascular tone through endothelial cell (EC) hyperpolarization and endothelium-dependent hyperpolarization-mediated vasodilation. However, the mechanism by which TRPC3 regulates these processes remains unresolved. We tested the hypothesis that endothelial receptor stimulation triggers rapid TRPC3 trafficking to the plasma membrane, where it provides the source of Ca2+ influx for small conductance calcium-activated K+ (SKCa) channel activation and sustained EC hyperpolarization. Methods and Results-Pressurized artery studies were performed with isolated mouse posterior cerebral artery. Treatment with a selective TRPC3 blocker (Pyr3) produced significant attenuation of endothelium-dependent hyperpolarization-mediated vasodilation and endothelial Ca2+ response (EC-specific Ca2+ biosensor) to intraluminal ATP. Pyr3 treatment also resulted in a reduced ATP-stimulated global Ca2+ and Ca2+ influx in primary cultures of cerebral endothelial cells. Patch-clamp studies with freshly isolated cerebral ECs demonstrated 2 components of EC hyperpolarization and K+ current activation in response to ATP. The early phase was dependent on intermediate conductance calcium-activated K+ channel activation, whereas the later sustained phase relied on SKCa channel activation. The SKCa channel-dependent phase was completely blocked with TRPC3 channel inhibition or in ECs of TRPC3 knockout mice and correlated with increased trafficking of TRPC3 (but not SKCa channel) to the plasma membrane. Conclusions-We propose that TRPC3 dynamically regulates SKCa channel activation through receptor-dependent trafficking to the plasma membrane, where it provides the source of Ca2+ influx for sustained SKCa channel activation, EC hyperpolarization, and endothelium-dependent hyperpolarization-mediated vasodilation. C1 [Kochukov, Mikhail Y.; Balasubramanian, Adithya; Marrelli, Sean P.] Baylor Coll Med, Dept Anesthesiol, Houston, TX 77030 USA. [Marrelli, Sean P.] Baylor Coll Med, Dept Physiol & Biophys, Houston, TX 77030 USA. [Marrelli, Sean P.] Baylor Coll Med, Grad Program Physiol, Houston, TX 77030 USA. [Abramowitz, Joel; Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Div Intramural Res, Res Triangle Pk, NC USA. RP Marrelli, SP (reprint author), One Baylor Plaza,Suite 433D, Houston, TX 77030 USA. EM marrelli@bcm.edu RI Abramowitz, Joel/A-2620-2015 FU National Institutes of Health (NIH), National Heart, Lung, and Blood Institute [R01 HL088435]; NIH [Z01-ES101684] FX This study was supported by National Institutes of Health (NIH), National Heart, Lung, and Blood Institute grant R01 HL088435 to Dr Marrelli and by the Intramural Research Program of the NIH (project Z01-ES101684 to Dr Birnbaumer). NR 60 TC 6 Z9 6 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD AUG PY 2014 VL 3 IS 4 AR e000913 DI 10.1161/JAHA.114.000913 PG 17 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AO4HD UT WOS:000341296600025 ER PT J AU Oliver, LM Fisher, WS Dittmar, J Hallock, P Campbell, J Quarles, RL Harris, P LoBue, C AF Oliver, L. M. Fisher, W. S. Dittmar, J. Hallock, P. Campbell, J. Quarles, R. L. Harris, P. LoBue, C. TI Contrasting responses of coral reef fauna and foraminiferal assemblages to human influence in La Parguera, Puerto Rico SO MARINE ENVIRONMENTAL RESEARCH LA English DT Article DE Coral reef; Human disturbance gradient; Sediment contaminants; Stressors ID FISH ASSEMBLAGES; TEMPORAL PATTERNS; SEDIMENTATION; TERRESTRIAL; INDICATORS; STRESS AB Coral reef biota including stony corals, sponges, gorgonians, fish, benthic macroinvertebrates and foraminifera were surveyed in coastal waters near La Parguera, in southwestern Puerto Rico. The goal was to evaluate sensitivity of coral reef biological indicators to human disturbance. Proxies for human disturbance were measured as distance to town (DTT) and rankings of a low-level sediment contamination gradient analyzed from a previous study. Contaminant rank and DTT showed that percent mud, stony coral taxa richness, reef rugosity, and numbers of invertebrates and sponges were higher at sites closer to human disturbance, but a foraminiferal assemblage index was significantly lower at sites with higher proxies for human disturbance. Fish indicators showed no significant relationships with human activity, but associations between fish community measures and certain measures of stony corals, gorgonians and sponges were found. Contrasting responses between foraminifera and reef organisms may be due to greater exposure and sensitivity of foraminifera to sediment contaminants. Published by Elsevier Ltd. C1 [Oliver, L. M.; Fisher, W. S.; Dittmar, J.; Quarles, R. L.; Harris, P.] US Environm Protect Agcy, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Hallock, P.; Campbell, J.] Univ S Florida, St Petersburg, FL 33701 USA. [LoBue, C.] US Environm Protect Agcy, New York, NY 10007 USA. RP Oliver, LM (reprint author), US Environm Protect Agcy, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM oliver.leah@epa.gov NR 47 TC 0 Z9 0 U1 1 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-1136 EI 1879-0291 J9 MAR ENVIRON RES JI Mar. Environ. Res. PD AUG PY 2014 VL 99 BP 95 EP 105 DI 10.1016/j.marenvres.2014.04.005 PG 11 WC Environmental Sciences; Marine & Freshwater Biology; Toxicology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Toxicology GA AN6JA UT WOS:000340699600012 PM 24840256 ER PT J AU Furr, JR Lambright, CS Wilson, VS Foster, PM Gray, LE AF Furr, Johnathan R. Lambright, Christy S. Wilson, Vickie S. Foster, Paul M. Gray, Leon E., Jr. TI A Short-term In Vivo Screen Using Fetal Testosterone Production, a Key Event in the Phthalate Adverse Outcome Pathway, to Predict Disruption of Sexual Differentiation SO TOXICOLOGICAL SCIENCES LA English DT Article DE Phthalate Syndrome; Fetal endocrine biomarkers; Phthalate adverse outcome pathway; testosterone production; fetal rat testis ID N-BUTYL PHTHALATE; SPRAGUE-DAWLEY RAT; ANDROGEN-RECEPTOR ANTAGONIST; INDUCED TESTICULAR ATROPHY; REPRODUCTIVE DEVELOPMENT; DEVELOPMENTAL TOXICITY; DIISOBUTYL PHTHALATE; GENE-EXPRESSION; DIETHYLHEXYL PHTHALATE; DI(N-BUTYL) PHTHALATE AB This study was designed to develop and validate a short-term in vivo protocol termed the Fetal Phthalate Screen (FPS) to detect phthalate esters (PEs) and other chemicals that disrupt fetal testosterone synthesis and testis gene expression in rats. We propose that the FPS can be used to screen chemicals that produce adverse developmental outcomes via disruption of the androgen synthesis pathway more rapidly and efficiently, and with fewer animals than a postnatal one-generation study. Pregnant rats were dosed from gestational day (GD) 14 to 18 at one dose level with one of 27 chemicals including PEs, PE alternatives, pesticides known to inhibit steroidogenesis, an estrogen and a potent PPAR alpha agonist and ex vivo testis testosterone production (T Prod) was measured on GD 18. We also included some chemicals with "unknown" activity including DMEP, DHeP, DHEH, DPHCH, DAP, TOTM, tetrabromodiethyl hexyl phthalate (BrDEHP), and a relatively potent environmental estrogen BPAF. Dose-response studies also were conducted with this protocol with 11 of the above chemicals to determine their relative potencies. CD-1 mice also were exposed to varying dose levels of DPeP from GD 13 to 17 to determine if DPeP reduced T Prod in this species since there is a discrepancy among the results of in utero studies of PEs in mice. Compared to the known male reproductive effects of the PEs in rats the FPS correctly identified all known "positives" and "negatives" tested. Seven of eight "unknowns" tested were "negatives", they did not reduce T Prod, whereas DAP produced an "equivocal" response. Finally, a dose-response study with DPeP in CD-1 mice revealed that fetal T Prod can be inhibited by exposure to a PE in utero in this species, but at a higher dose level than required in rats. Key words. Phthalate Syndrome, Fetal endocrine biomarkers, Phthalate adverse outcome pathway, testosterone production, fetal rat testis. C1 [Furr, Johnathan R.; Lambright, Christy S.; Wilson, Vickie S.; Gray, Leon E., Jr.] US EPA, Reprod Toxicol Branch, TAD, NHEERL,ORD, Res Triangle Pk, NC 27711 USA. [Foster, Paul M.] NIEHS, Natl Toxicol Program, NIH, DHHS, Res Triangle Pk, NC 27709 USA. RP Gray, LE (reprint author), Mail Code B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gray.ear@epa.gov OI Wilson, Vickie/0000-0003-1661-8481 FU National Institute of Environmental Health Sciences, National Institutes of Health; National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH); NTP/NIEHS IA [RW7592285501-1] FX Intramural Research Program of the National Institute of Environmental Health Sciences, National Institutes of Health (in part); National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH); NTP/NIEHS IA (RW7592285501-1). NR 81 TC 16 Z9 16 U1 2 U2 27 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD AUG PY 2014 VL 140 IS 2 BP 403 EP 424 DI 10.1093/toxsci/kfu081 PG 22 WC Toxicology SC Toxicology GA AN6DL UT WOS:000340684100014 PM 24798384 ER PT J AU Bosveld, FC Baas, P Steeneveld, GJ Holtslag, AAM Angevine, WM Bazile, E de Bruijn, EIF Deacu, D Edwards, JM Ek, M Larson, VE Pleim, JE Raschendorfer, M Svensson, G AF Bosveld, Fred C. Baas, Peter Steeneveld, Gert-Jan Holtslag, Albert A. M. Angevine, Wayne M. Bazile, Eric de Bruijn, Evert I. F. Deacu, Daniel Edwards, John M. Ek, Michael Larson, Vincent E. Pleim, Jonathan E. Raschendorfer, Matthias Svensson, Gunilla TI The Third GABLS Intercomparison Case for Evaluation Studies of Boundary-Layer Models. Part B: Results and Process Understanding SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Diurnal cycle; Evening transition; GABLS; Land-atmosphere interaction; Low-level jet; Model evaluation; Model intercomparison; Morning transition; Single-column models; Stable boundary layer ID STABLY STRATIFIED CONDITIONS; OBSERVED EVENING TRANSITION; NONLOCAL CLOSURE-MODEL; LOW-LEVEL JETS; LAND-SURFACE; MORNING TRANSITION; VERTICAL DIFFUSION; RADIATIVE-TRANSFER; ENERGY-BALANCE; ECMWF MODEL AB We describe and analyze the results of the third global energy and water cycle experiment atmospheric boundary layer Study intercomparison and evaluation study for single-column models. Each of the nineteen participating models was operated with its own physics package, including land-surface, radiation and turbulent mixing schemes, for a full diurnal cycle selected from the Cabauw observatory archive. By carefully prescribing the temporal evolution of the forcings on the vertical column, the models could be evaluated against observations. We focus on the gross features of the stable boundary layer (SBL), such as the onset of evening momentum decoupling, the 2-m minimum temperature, the evolution of the inertial oscillation and the morning transition. New process diagrams are introduced to interpret the variety of model results and the relative importance of processes in the SBL; the diagrams include the results of a number of sensitivity runs performed with one of the models. The models are characterized in terms of thermal coupling to the soil, longwave radiation and turbulent mixing. It is shown that differences in longwave radiation schemes among the models have only a small effect on the simulations; however, there are significant variations in downward radiation due to different boundary-layer profiles of temperature and humidity. The differences in modelled thermal coupling to the land surface are large and explain most of the variations in 2-m air temperature and longwave incoming radiation among models. Models with strong turbulent mixing overestimate the boundary-layer height, underestimate the wind speed at 200 m, and give a relatively large downward sensible heat flux. The result is that 2-m air temperature is relatively insensitive to turbulent mixing intensity. Evening transition times spread 1.5 h around the observed time of transition, with later transitions for models with coarse resolution. Time of onset in the morning transition spreads 2 h around the observed transition time. With this case, the morning transition appeared to be difficult to study, no relation could be found between the studied processes, and the variation in the time of the morning transition among the models. C1 [Bosveld, Fred C.; Baas, Peter; de Bruijn, Evert I. F.] Royal Netherlands Meteorol Inst, NL-3730 AE De Bilt, Netherlands. [Steeneveld, Gert-Jan; Holtslag, Albert A. M.] Wageningen Univ, NL-6700 AP Wageningen, Netherlands. [Angevine, Wayne M.] Univ Colorado, CIRES, NOAA Earth Syst Res Lab, Boulder, CO 80309 USA. [Bazile, Eric] Meteo France, Toulouse, France. [Deacu, Daniel] Environm Canada, Gatineau, PQ, Canada. [Edwards, John M.] MetOffice, Exeter, Devon, England. [Ek, Michael] Natl Ctr Environm Predict, Washington, DC USA. [Larson, Vincent E.] Univ Wisconsin, Milwaukee, WI 53201 USA. [Pleim, Jonathan E.] US EPA, Res Triangle Pk, NC 27711 USA. [Raschendorfer, Matthias] Deutsch Wetterdienst, Offenbach, Germany. [Svensson, Gunilla] Stockholm Univ, Dept Meteorol, S-10691 Stockholm, Sweden. [Svensson, Gunilla] Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden. RP Bosveld, FC (reprint author), Royal Netherlands Meteorol Inst, POB 201, NL-3730 AE De Bilt, Netherlands. EM fred.bosveld@knmi.nl RI Steeneveld, Gert-Jan/B-2816-2010; Angevine, Wayne/H-9849-2013; Pleim, Jonathan Pleim/C-1331-2017; Holtslag, Albert/B-7842-2010; Manager, CSD Publications/B-2789-2015 OI Steeneveld, Gert-Jan/0000-0002-5922-8179; Angevine, Wayne/0000-0002-8021-7116; Pleim, Jonathan Pleim/0000-0001-6190-6082; Holtslag, Albert/0000-0003-0995-2481; FU BSIK-ME2 research program (Climate changes spatial planning); NWO [863.10.010] FX Ayrton Zadra of GEM, Joshua Fasching of Wisconsin University, Frank Freedman of NCEP, Juergen Helmert of DWD and Florence Bocquet then at Stockholm University are acknowledged for contributing to the simulations. Jocelyn Mailhot of GEM is acknowledged for valuable comments on the paper. G. J. Steeneveld acknowledges financial support from the BSIK-ME2 research program (Climate changes spatial planning) and from NWO contract 863.10.010. NR 93 TC 25 Z9 25 U1 2 U2 24 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 EI 1573-1472 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD AUG PY 2014 VL 152 IS 2 SI SI BP 157 EP 187 DI 10.1007/s10546-014-9919-1 PG 31 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AN2JC UT WOS:000340409900003 ER PT J AU Pastoor, TP Bachman, AN Bell, DR Cohen, SM Dellarco, M Dewhurst, IC Doe, JE Doerrer, NG Embry, MR Hines, RN Moretto, A Phillips, RD Rowlands, JC Tanir, JY Wolf, DC Boobis, AR AF Pastoor, Timothy P. Bachman, Ammie N. Bell, David R. Cohen, Samuel M. Dellarco, Michael Dewhurst, Ian C. Doe, John E. Doerrer, Nancy G. Embry, Michelle R. Hines, Ronald N. Moretto, Angelo Phillips, Richard D. Rowlands, J. Craig Tanir, Jennifer Y. Wolf, Douglas C. Boobis, Alan R. TI A 21st century roadmap for human health risk assessment SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE exposure; framework; hazard; problem formulation; risk; risk assessment; risk policy; tiered ID TOXICOLOGICAL CONCERN; SUBSTANCES PRESENT; DOSE-RESPONSE; FRAMEWORK; THRESHOLDS; DIET AB The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISK21 participants that guided its development. Subsequent papers describe the roadmap and matrix in greater detail. RISK21 principles include focusing on problem formulation, utilizing existing information, starting with exposure assessment (rather than toxicity), and using a tiered process for data development. Bringing estimates of exposure and toxicity together on a two-dimensional matrix provides a clear rendition of human safety and risk. The value of the roadmap is its capacity to chronicle the stepwise acquisition of scientific information and display it in a clear and concise fashion. Furthermore, the tiered approach and transparent display of information will contribute to greater efficiencies by calling for data only as needed (enough precision to make a decision), thus conserving animals and other resources. C1 [Pastoor, Timothy P.] Syngenta Ltd, Greensboro, NC USA. [Bachman, Ammie N.; Phillips, Richard D.] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Bell, David R.] European Chem Agcy, Helsinki, Finland. [Cohen, Samuel M.] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA. [Dellarco, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA. [Dewhurst, Ian C.] UK Chem Regulat Directorate, York, N Yorkshire, England. [Doe, John E.] Parker Doe Partnership LLP, Frodsham, Cheshire, England. [Doerrer, Nancy G.; Embry, Michelle R.; Tanir, Jennifer Y.] ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA. [Hines, Ronald N.; Wolf, Douglas C.] US EPA, ORD, NHEERL, Res Triangle Pk, NC 27711 USA. [Moretto, Angelo] Univ Milan, Dept Biomed & Clin Sci, Milan, Italy. [Rowlands, J. Craig] Dow Chem Co USA, Midland, MI 48674 USA. [Boobis, Alan R.] Univ London Imperial Coll Sci Technol & Med, London, England. RP Embry, MR (reprint author), ILSI Hlth & Environm Sci Inst, 1156 15th St NW, Washington, DC 20005 USA. EM membry@hesiglobal.org RI Doe, Jane/B-8500-2015; OI Moretto, Angelo/0000-0003-4386-5736 FU International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI); NGOs FX This manuscript was prepared under the auspices of the International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI), a non-profit organization aimed at engaging scientists from academia, government, industry, research institutes, and NGOs to identify and resolve global health and environmental issues. ILSI HESI collects funding from member companies to support projects. The authors' affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views of the authors' employers or the opinions or policies of the US EPA or NIH. Mention of trade names does not constitute endorsement. None of the authors has recently or is currently involved as an expert witness in litigation or formal government rule-making on the subject of this paper. The authors employed by ILSI HESI participated as part of their normal employment. No other authors received financial support or an honorarium in the preparation of this paper. The authors declare that there are no conflicts of interest. NR 16 TC 26 Z9 27 U1 2 U2 23 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD AUG PY 2014 VL 44 SU 3 BP 1 EP 5 DI 10.3109/10408444.2014.931923 PG 5 WC Toxicology SC Toxicology GA AN1RB UT WOS:000340360200001 PM 25070413 ER PT J AU Embry, MR Bachman, AN Bell, DR Boobis, AR Cohen, SM Dellarco, M Dewhurst, IC Doerrer, NG Hines, RN Moretto, A Pastoor, TP Phillips, RD Rowlands, JC Tanir, JY Wolf, DC Doe, JE AF Embry, Michelle R. Bachman, Ammie N. Bell, David R. Boobis, Alan R. Cohen, Samuel M. Dellarco, Michael Dewhurst, Ian C. Doerrer, Nancy G. Hines, Ronald N. Moretto, Angelo Pastoor, Timothy P. Phillips, Richard D. Rowlands, J. Craig Tanir, Jennifer Y. Wolf, Douglas C. Doe, John E. TI Risk assessment in the 21st century: Roadmap and matrix SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE exposure; framework; hazard; problem formulation; risk; risk assessment; risk policy; tiered ID CHEMICALS; EXPOSURE AB The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix. This paper describes in detail the process for using the roadmap and matrix. The purpose of this methodology is to optimize the use of prior information and testing resources (animals, time, facilities, and personnel) to efficiently and transparently reach a risk and/or safety determination. Based on the particular problem, exposure and toxicity data should have sufficient precision to make such a decision. Estimates of exposure and toxicity, bounded by variability and/or uncertainty, are plotted on the X- and Y-axes of the RISK21 matrix, respectively. The resulting intersection is a highly visual representation of estimated risk. Decisions can then be made to increase precision in the exposure or toxicity estimates or declare that the available information is sufficient. RISK21 represents a step forward in the goal to introduce new methodologies into 21st century risk assessment. Indeed, because of its transparent and visual process, RISK21 has the potential to widen the scope of risk communication beyond those with technical expertise. C1 [Embry, Michelle R.; Doerrer, Nancy G.; Tanir, Jennifer Y.] ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA. [Bachman, Ammie N.; Phillips, Richard D.] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Bell, David R.] European Chem Agcy, Helsinki, Finland. [Boobis, Alan R.] Univ London Imperial Coll Sci Technol & Med, London, England. [Cohen, Samuel M.] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA. [Dellarco, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA. [Dewhurst, Ian C.] UK Chem Regulat Directorate, York, N Yorkshire, England. [Hines, Ronald N.; Wolf, Douglas C.] US EPA, Res Triangle Pk, NC USA. [Moretto, Angelo] Univ Milan, Dept Biomed & Clin Sci, Milan, Italy. [Pastoor, Timothy P.] Syngenta Ltd, Greensboro, NC USA. [Rowlands, J. Craig] Dow Chem Co USA, Midland, MI 48674 USA. [Doe, John E.] Parker Doe Partnership LLP, Stockport, Cheshire, England. RP Embry, MR (reprint author), ILSI Hlth & Environm Sci Inst, 1156 15th St NW,Second Floor, Washington, DC 20005 USA. EM membry@hesiglobal.org RI Doe, Jane/B-8500-2015; OI Moretto, Angelo/0000-0003-4386-5736 FU International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI); NGOs FX This manuscript was prepared under the auspices of the International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI), a non-profit organization aimed at engaging scientists from academia, government, industry, research institutes, and NGOs to identify and resolve global health and environmental issues. ILSI HESI collects funding from member companies to support projects. The authors' affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views of the authors' employers or the opinions or policies of the US EPA or NIH. Mention of trade names does not constitute endorsement. None of the authors has recently or is currently involved as an expert witness in litigation or formal government rule-making on the subject of this paper. The authors employed by ILSI HESI participated as part of their normal employment. No other authors received financial support or an honorarium in the preparation of this paper. The authors declare that there are no conflicts of interest. NR 24 TC 26 Z9 27 U1 2 U2 16 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD AUG PY 2014 VL 44 SU 3 BP 6 EP 16 DI 10.3109/10408444.2014.931924 PG 11 WC Toxicology SC Toxicology GA AN1RB UT WOS:000340360200002 PM 25070414 ER PT J AU Simon, TW Simons, SS Preston, RJ Boobis, AR Cohen, SM Doerrer, NG Fenner-Crisp, PA McMullin, TS McQueen, CA Rowlands, JC AF Simon, Ted W. Simons, S. Stoney, Jr. Preston, R. Julian Boobis, Alan R. Cohen, Samuel M. Doerrer, Nancy G. Fenner-Crisp, Penelope A. McMullin, Tami S. McQueen, Charlene A. Rowlands, J. Craig CA RISK21 Dose-Response Subteam TI The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE associative event; key event; mode of action; modulating factor; Q-KEDRF; risk assessment ID ESTROGEN-RECEPTOR-ALPHA; PHARMACODYNAMIC PBPK/PD MODEL; HUMAN PROGESTERONE-RECEPTOR; HUMAN RELEVANCE ANALYSIS; RAT UTEROTROPHIC ASSAY; CONTINUOUS END-POINTS; REPORTER GENE ASSAY; TO-OUTCOME MODEL; BISPHENOL-A; IN-VIVO AB The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in silico) to advance the next-generation of chemical risk assessments. A goal of the Subteam is to enhance the existing Mode of Action/Human Relevance Framework and Key Events/Dose Response Framework (KEDRF) to make the best use of quantitative dose-response and timing information for Key Events (KEs). The resulting Quantitative Key Events/Dose-Response Framework (Q-KEDRF) provides a structured quantitative approach for systematic examination of the dose-response and timing of KEs resulting from a dose of a bioactive agent that causes a potential adverse outcome. Two concepts are described as aids to increasing the understanding of mode of action-Associative Events and Modulating Factors. These concepts are illustrated in two case studies; 1) cholinesterase inhibition by the pesticide chlorpyrifos, which illustrates the necessity of considering quantitative dose-response information when assessing the effect of a Modulating Factor, that is, enzyme polymorphisms in humans, and 2) estrogen-induced uterotrophic responses in rodents, which demonstrate how quantitative dose-response modeling for KE, the understanding of temporal relationships between KEs and a counterfactual examination of hypothesized KEs can determine whether they are Associative Events or true KEs. C1 [Simon, Ted W.] Ted Simon LLC, Winston, GA USA. [Simons, S. Stoney, Jr.] NIDDK, Steroid Hormones Sect, LERB, NIH, Bethesda, MD USA. [Preston, R. Julian; McQueen, Charlene A.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Boobis, Alan R.] Univ London Imperial Coll Sci Technol & Med, London, England. [Cohen, Samuel M.] Univ Nebraska Med Ctr, Omaha, NE USA. [Doerrer, Nancy G.; RISK21 Dose-Response Subteam] ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA. [McMullin, Tami S.] Dow Corning Corp, Midland, MI USA. [Rowlands, J. Craig] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. RP Doerrer, NG (reprint author), ILSI Hlth & Environm Sci Inst, 1156 15th St NW, Washington, DC 20005 USA. EM ndoerrer@hesiglobal.org OI Teeguarden, Justin/0000-0003-3817-4391 FU International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI); NGOs FX This manuscript was prepared under the auspices of the International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI), a non-profit organization aimed at engaging scientists from academia, government, industry, research institutes, and NGOs to identify and resolve global health and environmental issues. ILSI HESI collects funding from member companies to support projects. The authors' affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views of the authors' employers or the opinions or policies of the US EPA or NIH. Mention of trade names does not constitute endorsement. None of the authors has recently or is currently involved as an expert witness in litigation or formal government rule-making on the subject of this paper. The authors employed by ILSI HESI participated as part of their normal employment. No other authors received financial support or an honorarium in the preparation of this paper. The authors declare that there are no conflicts of interest. NR 197 TC 24 Z9 24 U1 0 U2 30 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD AUG PY 2014 VL 44 SU 3 BP 17 EP 43 DI 10.3109/10408444.2014.931925 PG 27 WC Toxicology SC Toxicology GA AN1RB UT WOS:000340360200003 PM 25070415 ER PT J AU Lehmann, GM Verner, MA Luukinen, B Henning, C Assimon, SA LaKind, JS McLanahan, ED Phillips, LJ Davis, MH Powers, CM Hines, EP Haddad, S Longnecker, MP Poulsen, MT Farrer, DG Marchitti, SA Tan, YM Swartout, JC Sagiv, SK Welsh, C Campbell, JL Foster, WG Yang, RSH Fenton, SE Tornero-Velez, R Francis, BM Barnett, JB El-Masri, HA Simmons, JE AF Lehmann, Geniece M. Verner, Marc-Andre Luukinen, Bryan Henning, Cara Assimon, Sue Anne LaKind, Judy S. McLanahan, Eva D. Phillips, Linda J. Davis, Matthew H. Powers, Christina M. Hines, Erin P. Haddad, Sami Longnecker, Matthew P. Poulsen, Michael T. Farrer, David G. Marchitti, Satori A. Tan, Yu-Mei Swartout, Jeffrey C. Sagiv, Sharon K. Welsh, Clement Campbell, Jerry L., Jr. Foster, Warren G. Yang, Raymond S. H. Fenton, Suzanne E. Tornero-Velez, Rogelio Francis, Bettina M. Barnett, John B. El-Masri, Hisham A. Simmons, Jane Ellen TI Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE children; exposure; PBT chemicals; persistent organic pollutants; POPs; research needs; risk assessment; uncertainty ID CHILDRENS HEALTH; POLYCHLORINATED-BIPHENYLS; PARTITION-COEFFICIENTS; LACTATIONAL TRANSFER; UNITED-STATES; PHARMACOKINETIC MODELS; TECHNICAL WORKSHOP; CRITICAL WINDOWS; INFANT EXPOSURE; EXPERT PANEL AB Lipophilic persistent environmental chemicals (LPECs) have the potential to accumulate within a woman's body lipids over the course of many years prior to pregnancy, to partition into human milk, and to transfer to infants upon breastfeeding. As a result of this accumulation and partitioning, a breastfeeding infant's intake of these LPECs may be much greater than his/her mother's average daily exposure. Because the developmental period sets the stage for lifelong health, it is important to be able to accurately assess chemical exposures in early life. In many cases, current human health risk assessment methods do not account for differences between maternal and infant exposures to LPECs or for lifestage-specific effects of exposure to these chemicals. Because of their persistence and accumulation in body lipids and partitioning into breast milk, LPECs present unique challenges for each component of the human health risk assessment process, including hazard identification, dose-response assessment, and exposure assessment. Specific biological modeling approaches are available to support both dose-response and exposure assessment for lactational exposures to LPECs. Yet, lack of data limits the application of these approaches. The goal of this review is to outline the available approaches and to identify key issues that, if addressed, could improve efforts to apply these approaches to risk assessment of lactational exposure to these chemicals. C1 [Lehmann, Geniece M.; McLanahan, Eva D.; Powers, Christina M.; Hines, Erin P.; Tan, Yu-Mei; Tornero-Velez, Rogelio; El-Masri, Hisham A.; Simmons, Jane Ellen] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Verner, Marc-Andre] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA. [Luukinen, Bryan; Henning, Cara] ICF Int, Res Triangle Pk, NC USA. [Assimon, Sue Anne] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA. [LaKind, Judy S.] LaKind Associates LLC, Catonsville, MD USA. [LaKind, Judy S.] Univ Maryland Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD USA. [LaKind, Judy S.] Penn State Univ Coll Med, Dept Pediat, Hershey, PA USA. [Phillips, Linda J.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Davis, Matthew H.] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA. [Haddad, Sami] Univ Quebec, Dept Environm Hlth & Occupat Hlth, IRSPUM Univ Montreal Publ Hlth Res Inst, Montreal, PQ H3C 3P8, Canada. [Longnecker, Matthew P.; Fenton, Suzanne E.] NIEHS, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA. [Poulsen, Michael T.] Oregon Dept Environm Qual, Portland, OR USA. [Farrer, David G.] Oregon Hlth Author, Portland, OR USA. [Marchitti, Satori A.] US EPA, Off Res & Dev, Athens, GA USA. [Swartout, Jeffrey C.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Sagiv, Sharon K.] Boston Univ Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Welsh, Clement] Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA USA. [Campbell, Jerry L., Jr.] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA. [Foster, Warren G.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada. [Yang, Raymond S. H.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA. [Francis, Bettina M.] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA. [Barnett, John B.] West Virginia Univ Sch Med, Dept Microbiol Immunol & Cell Biol, Morgantown, WV USA. RP Lehmann, GM (reprint author), US EPA, MD B243-01,4930 Old Page Rd, Durham, NC 27703 USA. EM lehmann.geniece@epa.gov RI Haddad, Sami/F-4537-2012; OI Haddad, Sami/0000-0001-8906-9693; Hines, Erin Pias/0000-0002-2458-6267; Verner, Marc-Andre/0000-0002-1935-8913; Longnecker, Matthew/0000-0001-6073-5322 FU U.S. EPA [EP-C-09-009, 2-62, 3-62, 4-62]; Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS); NIH FX The employment affiliation of the authors is shown on the cover page. The following authors were participants in a multidisciplinary workshop that served as the basis for this review paper: MAV, SAA, JSL, MHD, SH, MPL, MTP, DGF, YMT, SKS, CW, JCS, JLC, WGF, BMF, RSHY, JBB, HAE, SEF, JES, and RT. Some workshop participants chose not to participate as authors in the development of this review. Those individuals are acknowledged in the preceding section. The workshop was co-chaired by GML and EDM. ICF International organized the workshop under contract from the U.S. EPA (Contract No. EP-C-09-009, Work Assignments 2-62, 3-62, and 4-62). Workshop organization functions performed by ICF International included the independent identification and selection of workshop participants. ICF International is a for-profit firm providing professional services and technology solutions to clients in the following markets: energy, environment, and infrastructure; health, social programs, and consumer/financial; and public safety and defense. ICF International provides these services to both government and private sector clients. This research was also supported [in part] by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS). The following workshop participants received support for travel and/or lodging: MAV, SAA, JSL, MHD, SH, MTP, DGF, SKS, WGF, BMF, RSHY, and JBB. MAV, SH, SKS, JLC, WGF, BMF, RSHY, JBB, and JSL received an honorarium for their participation in the workshop. LaKind Associates is a private consulting firm specializing in strategic risk management, assessment of human exposures and health risks, biomonitoring, state-of-the-science reviews, and environmental regulatory review; LaKind Associates consults to governmental and private sectors. The Hamner Institutes for Health Sciences is a nonprofit research institute with a primary focus on drug and chemical safety, including the development of methods to improve human health risk assessment. This paper has been reviewed in accordance with the peer and administrative review policies of the U. S. EPA, Food and Drug Administration (FDA), NIEHS, and Agency for Toxic Substances and Disease Registry (ATSDR) and approved for publication. The views expressed in this report are those of the authors and do not necessarily reflect the opinions and/or policies of the U. S. EPA, FDA, NIEHS or ATSDR. The remaining authors are all employees of either state governments or various academic institutions. Many of the academic scientists participating in the workshop and authoring this paper have received financial support for their research programs from the U.S. EPA and/or the NIH. All authors have sole responsibility as individual scientists for the writing and content of this review. The views, conclusions and recommendations are not necessarily those of their employers. NR 80 TC 7 Z9 7 U1 1 U2 24 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD AUG PY 2014 VL 44 IS 7 BP 600 EP 617 DI 10.3109/10408444.2014.926306 PG 18 WC Toxicology SC Toxicology GA AN1QZ UT WOS:000340360000005 PM 25068490 ER PT J AU Cavallin, JE Durhan, EJ Evans, N Jensen, KM Kahl, MD Kolpin, DW Kolodziej, EP Foreman, WT LaLone, CA Makynen, EA Seidl, SM Thomas, LM Villeneuve, DL Weberg, MA Wilson, VS Ankley, GT AF Cavallin, Jenna E. Durhan, Elizabeth J. Evans, Nicola Jensen, Kathleen M. Kahl, Michael D. Kolpin, Dana W. Kolodziej, Edward P. Foreman, William T. LaLone, Carlie A. Makynen, Elizabeth A. Seidl, Sara M. Thomas, Linnea M. Villeneuve, Daniel L. Weberg, Matthew A. Wilson, Vickie S. Ankley, Gerald T. TI INTEGRATED ASSESSMENT OF RUNOFF FROM LIVESTOCK FARMING OPERATIONS: ANALYTICAL CHEMISTRY, IN VITRO BIOASSAYS, AND IN VIVO FISH EXPOSURES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Complex mixture; Livestock operation; Fathead minnow; Gene expression; Steroid hormone ID MINNOW PIMEPHALES-PROMELAS; TRENBOLONE ACETATE METABOLITES; FATHEAD MINNOW; CELL-LINE; STABLY EXPRESSES; ANIMAL MANURE; VITELLOGENIN; ESTROGENS; COMPENSATION; KETOCONAZOLE AB Animal waste from livestock farming operations can contain varying levels of natural and synthetic androgens and/or estrogens, which can contaminate surrounding waterways. In the present study, surface stream water was collected from 6 basins containing livestock farming operations. Aqueous concentrations of 12 hormones were determined via chemical analyses. Relative androgenic and estrogenic activity was measured using in vitro cell assays (MDA-kb2 and T47D-Kbluc assays, respectively). In parallel, 48-h static-renewal in vivo exposures were conducted to examine potential endocrine-disrupting effects in fathead minnows. Mature fish were exposed to surface water dilutions (0%, 25%, 50%, and 100%) and 10-ng/L of 17 alpha-ethynylestradiol or 50-ng/L of 17 beta-trenbolone as positive controls. Hepatic expression of vitellogenin and estrogen receptor a mRNA, gonadal ex vivo testosterone and 17 beta-estradiol production, and plasma vitellogenin concentrations were examined. Potentially estrogenic and androgenic steroids were detected at low nanogram per liter concentrations. In vitro estrogenic activity was detected in all samples, whereas androgenic activity was detected in only 1 sample. In vivo exposures to the surface water had no significant dose-dependent effect on any of the biological endpoints, with the exception of increased male testosterone production in 1 exposure. The present study, which combines analytical chemistry measurements, in vitro bioassays, and in vivo fish exposures, highlights the integrated value and future use of a combination of techniques to obtain a comprehensive characterization of an environmental chemical mixture. Environ Toxicol Chem 2014; 33: 1849-1857. Published 2014 Wiley Periodicals, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America. C1 [Cavallin, Jenna E.] US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Off Res & Dev, Duluth, MN 55804 USA. [Durhan, Elizabeth J.; Jensen, Kathleen M.; Kahl, Michael D.; LaLone, Carlie A.; Makynen, Elizabeth A.; Seidl, Sara M.; Thomas, Linnea M.; Villeneuve, Daniel L.; Weberg, Matthew A.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN USA. [Evans, Nicola; Wilson, Vickie S.] US EPA, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div, Off Res & Dev, Duluth, MN USA. [Kolpin, Dana W.] US Geol Survey, Iowa City, IA USA. [Kolodziej, Edward P.] Univ Nevada, Dept Civil & Environm Engn, Reno, NV 89557 USA. [Foreman, William T.] US Geol Survey, Natl Water Qual Lab, Denver, CO 80225 USA. RP Cavallin, JE (reprint author), US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Off Res & Dev, Duluth, MN 55804 USA. EM cavallin.jenna@epa.gov OI Kolodziej, Edward/0000-0002-7968-4198; Wilson, Vickie/0000-0003-1661-8481 NR 36 TC 13 Z9 13 U1 7 U2 74 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD AUG PY 2014 VL 33 IS 8 BP 1849 EP 1857 DI 10.1002/etc.2627 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AN4DD UT WOS:000340536900024 PM 24831736 ER PT J AU Parks, AN Chandler, GT Portis, LM Sullivan, JC Perron, MM Cantwell, MG Burgess, RM Ho, KT Ferguson, PL AF Parks, Ashley N. Chandler, G. Thomas Portis, Lisa M. Sullivan, Julia C. Perron, Monique M. Cantwell, Mark G. Burgess, Robert M. Ho, Kay T. Ferguson, P. Lee TI Effects of single-walled carbon nanotubes on the bioavailability of PCBs in field-contaminated sediments SO NANOTOXICOLOGY LA English DT Article DE Bioaccumulation; bioavailability; polychlorinated biphenyls; single-walled carbon nanotubes; toxicity ID POLYCYCLIC AROMATIC-HYDROCARBONS; ACTIVATED CARBON; BLACK CARBON; BENTHIC INVERTEBRATES; MARINE SEDIMENT; POLYCHLORINATED-BIPHENYLS; TOXICITY IDENTIFICATION; ORGANIC-COMPOUNDS; LIFE-CYCLE; BIOACCUMULATION AB Adsorption of hydrophobic organic contaminants (HOCs) to black carbon is a well-studied phenomenon. One emerging class of engineered black carbon materials are single-walled carbon nanotubes (SWNTs). Little research has investigated the potential of SWNT to adsorb and sequester HOCs in complex environmental systems. This study addressed the capacity of SWNT, amended to polychlorinated biphenyl (PCB)-contaminated New Bedford Harbor (NBH) sediment, to reduce the toxicity and bioaccumulation of these HOCs to benthic organisms. Overall, SWNT amendments increased the survival of two benthic estuarine invertebrates, Americamysis bahia and Ampelisca abdita, and reduced the accumulation of PCBs to the benthic polychaete, Nereis virens. Reduction in PCB bioaccumulation by SWNT was independent of K-ow. Further, passive sampling-based estimates of interstitial water concentrations indicated that SWNT reduced PCB bioavailability. Results from this study suggest that SWNT are a good adsorbent for PCBs and might be useful for remediation in the future once SWNT manufacturing technology improves and costs decrease. C1 [Parks, Ashley N.; Ferguson, P. Lee] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Chandler, G. Thomas] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Portis, Lisa M.; Sullivan, Julia C.; Cantwell, Mark G.; Burgess, Robert M.; Ho, Kay T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Perron, Monique M.] US EPA, Off Pesticides Program, Div Hlth Effects, Arlington, VA USA. [Ferguson, P. Lee] Duke Univ, Dept Civil & Environm Engn, Durham, NC 27706 USA. [Ferguson, P. Lee] Duke Univ, Ctr Environm Implicat NanoTechnol, Durham, NC USA. RP Burgess, RM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM burgess.robert@epa.gov RI Ferguson, Lee/A-5501-2013 FU U.S. Environmental Protection Agency FX We thank Dr. Philip Wallis and SouthWest NanoTechnologies for the generous gifts of SWNT materials. Although the research described in this article was supported in part by the U.S. Environmental Protection Agency, it has not been subjected to Agency review and, therefore, does not necessarily reflect the view of the Agency; no official endorsement should be inferred. NR 43 TC 10 Z9 12 U1 11 U2 71 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1743-5390 EI 1743-5404 J9 NANOTOXICOLOGY JI Nanotoxicology PD AUG PY 2014 VL 8 SU 1 BP 111 EP 117 DI 10.3109/17435390.2013.858794 PG 7 WC Nanoscience & Nanotechnology; Toxicology SC Science & Technology - Other Topics; Toxicology GA AN3YH UT WOS:000340524300011 PM 24266834 ER PT J AU Burke, RA Fritz, KM Barton, CD Johnson, BR Fulton, S Hardy, D Word, DA Jack, JD AF Burke, Roger A. Fritz, Ken M. Barton, Chris D. Johnson, Brent R. Fulton, Stephanie Hardy, Dean Word, David A. Jack, Jeff D. TI Impacts of Mountaintop Removal and Valley Fill Coal Mining on C and N Processing in Terrestrial Soils and Headwater Streams SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Mountaintop mining impacts; Headwater streams; Carbon and nitrogen cycling; Soil quality recovery ID DISSOLVED INORGANIC CARBON; ORGANIC-CARBON; RECLAIMED SOILS; MICROBIAL RESPIRATION; HYDROLOGICAL CONTROLS; CENTRAL APPALACHIANS; MINE DRAINAGE; LAND-USE; DENITRIFICATION; FOREST AB We measured C and N cycling indicators in Appalachian watersheds impacted by mountaintop removal and valley fill (MTR/VF) coal mining, and in nearby forested watersheds. These watersheds include ephemeral, intermittent, and perennial stream reaches, and the length of time since disturbance in the MTR/VF watersheds was 5 to 11 years. In forest soils compared to VF soils, both denitrification enzyme activity (DEA) and basal respiration (BR) were elevated (factor of 6 for DEA and factor of 1.8 for BR expressed on a weight basis) and bulk density was lower. Organic matter (OM) and moisture were higher in the forest soils, which likely contributed to the elevated DEA and BR levels, Evaluation of soils data from our intermittent watersheds as a chronosequence provides some evidence of soil quality (DEA, BR, and soil moisture) improvement over the course of a decade, at least in the top 5 cm. Across the hydrological permanence gradient, sediment DEA was significantly higher (factor of 1.6) and sediment OM was significantly lower in forested than in VF watersheds, whereas sediment BR did not differ between forested and VF watersheds, Dissolved organic carbon (DOC) concentrations were not different in mining-impacted and forested streams, whereas dissolved inorganic carbon (DIC) concentrations and DOC and DIC stable carbon isotopic compositions (delta C-13) were significantly elevated in VF streams. The delta C-13-DIC values indicate that carbonate dissolution was a dominant source of dissolved carbon in MIR/VF mining-impacted streams. The disturbance associated with MTR/VF mining significantly impacts C and N processing in soils, stream sediments, and stream water although our data suggests some improvement of soil quality during the first decade of reclamation. C1 [Burke, Roger A.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA. [Fritz, Ken M.; Johnson, Brent R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Barton, Chris D.] Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. [Fulton, Stephanie] US EPA, Watershed Protect Div, Atlanta, GA 30303 USA. [Hardy, Dean] Univ Georgia, Dept Geog, Athens, GA 30602 USA. [Word, David A.; Jack, Jeff D.] Univ Louisville, Dept Biol, Louisville, KY 40292 USA. [Word, David A.] St Francis Sch, Louisville, KY 40202 USA. RP Burke, RA (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA. EM burke.roger@epa.gov NR 50 TC 1 Z9 1 U1 2 U2 29 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 EI 1573-2932 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD AUG PY 2014 VL 225 IS 8 AR 2081 DI 10.1007/s11270-014-2081-z PG 17 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA AN3ZM UT WOS:000340527400043 ER PT J AU Colvin, J Dangel, C Bronstein, A AF Colvin, J. Dangel, C. Bronstein, A. TI Use of poison center follow-up surveys to investigate health-seeking behavior SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract DE Surveillance; Health Seeking Behavior; PoisonCenter Utilization C1 [Dangel, C.] US EPA, Cincinnati, OH 45268 USA. [Bronstein, A.] Rocky Mt Poison & Drug Ctr, Denver, CO USA. [Colvin, J.] Cincinnati Drug & Poison Informat Ctr, Cincinnati, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 EI 1556-9519 J9 CLIN TOXICOL JI Clin. Toxicol. PD AUG PY 2014 VL 52 IS 7 MA 216 BP 780 EP 780 PG 1 WC Toxicology SC Toxicology GA AN0UE UT WOS:000340298700223 ER PT J AU Kimm, VJ Cotruvo, JA Hoffbuhr, J Calvert, A AF Kimm, Victor J. Cotruvo, Joseph A. Hoffbuhr, Jack Calvert, Arden TI The Safe Drinking Water Act: The first 10 years SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article C1 [Kimm, Victor J.; Calvert, Arden] US EPA, Washington, DC USA. [Kimm, Victor J.] Univ So Calif, Grad Sch Publ Adm, Washington, DC USA. [Cotruvo, Joseph A.] Joseph Cotruvo & Associates, Washington, DC 20016 USA. RP Kimm, VJ (reprint author), Joseph Cotruvo & Associates, 5015 46th St NW, Washington, DC 20016 USA. EM joseph.cotruvo@verizon.net NR 0 TC 0 Z9 0 U1 4 U2 15 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD AUG PY 2014 VL 106 IS 8 BP 84 EP 95 DI 10.5942/jawwa.2014.106.0092 PG 12 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AM6PW UT WOS:000339988100012 ER PT J AU Hill, BH Elonen, CM Jicha, TM Kolka, RK Lehto, LLP Sebestyen, SD Seifert-Monson, LR AF Hill, Brian H. Elonen, Colleen M. Jicha, Terri M. Kolka, Randall K. Lehto, Larae L. P. Sebestyen, Stephen D. Seifert-Monson, Lindsey R. TI Ecoenzymatic stoichiometry and microbial processing of organic matter in northern bogs and fens reveals a common P-limitation between peatland types SO BIOGEOCHEMISTRY LA English DT Article DE Decomposition; Ecoenzymes; Peat; Soil; Stoichiometry ID CARBON-USE-EFFICIENCY; RIVERINE BACTERIOPLANKTON; THEORETICAL-MODEL; ENZYME-ACTIVITY; DECOMPOSITION; NITROGEN; SOIL; PHOSPHORUS; WETLANDS; GROWTH AB We compared carbon (C), nitrogen (N), and phosphorus (P) concentrations in atmospheric deposition, runoff, and soils with microbial respiration [dehydrogenase (DHA)] and ecoenzyme activity (EEA) in an ombrotrophic bog and a minerotrophic fen to investigate the environmental drivers of biogeochemical cycling in peatlands at the Marcell Experimental Forest in northern Minnesota, USA. Ecoenzymatic stoichiometry was used to construct models for C use efficiency (CUE) and decomposition (M), and these were used to model respiration (R-m). Our goals were to determine the relative C, N, and P limitations on microbial processes and organic matter decomposition, and to identify environmental constraints on ecoenzymatic processes. Mean annual water, C, and P yields were greater in the fen, while N yields were similar in both the bog and fen. Soil chemistry differed between the bog and fen, and both watersheds exhibited significant differences among soil horizons. DHA and EEA differed by watersheds and soil horizons, CUE, M, and R-m differed only by soil horizons. C, N, or P limitations indicated by EEA stoichiometry were confirmed with orthogonal regressions of ecoenzyme pairs and enzyme vector analyses, and indicated greater N and P limitation in the bog than in the fen, with an overall tendency toward P-limitation in both the bog and fen. Ecoenzymatic stoichiometry, microbial respiration, and organic matter decomposition were responsive to resource availability and the environmental drivers of microbial metabolism, including those related to global climate changes. C1 [Hill, Brian H.; Elonen, Colleen M.; Jicha, Terri M.; Lehto, Larae L. P.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA. [Kolka, Randall K.; Sebestyen, Stephen D.] US Forest Serv, Ctr Res Ecosyst Change, No Res Stn, Grand Rapids, MN 55744 USA. [Seifert-Monson, Lindsey R.] Univ Minnesota, Integrated Biosci Grad Program, Duluth, MN 55812 USA. RP Hill, BH (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM hill.brian@epa.gov RI Sebestyen, Stephen/D-1238-2013 OI Sebestyen, Stephen/0000-0002-6315-0108 NR 60 TC 16 Z9 16 U1 15 U2 111 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-2563 EI 1573-515X J9 BIOGEOCHEMISTRY JI Biogeochemistry PD AUG PY 2014 VL 120 IS 1-3 BP 203 EP 224 DI 10.1007/s10533-014-9991-0 PG 22 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA AM5BX UT WOS:000339871700013 ER PT J AU Weitzman, JN Forshay, KJ Kaye, JP Mayer, PM Koval, JC Walter, RC AF Weitzman, Julie N. Forshay, Kenneth J. Kaye, Jason P. Mayer, Paul M. Koval, Jason C. Walter, Robert C. TI Potential nitrogen and carbon processing in a landscape rich in milldam legacy sediments SO BIOGEOCHEMISTRY LA English DT Article DE Legacy sediments; Nitrogen; Biogeochemistry; Relict hydric soil ID ORGANIC-MATTER DECOMPOSITION; RIPARIAN WETLANDS; ECOENZYMATIC STOICHIOMETRY; MICROBIAL COMMUNITIES; CATABOLIC DIVERSITY; AQUATIC ECOSYSTEMS; STREAM RESTORATION; NITRATE DYNAMICS; ENZYME-ACTIVITY; SOIL-EROSION AB Recent identification of the widespread distribution of legacy sediments deposited in historic mill ponds has increased concern regarding their role in controlling land-water nutrient transfers in the mid-Atlantic region of the US. At Big Spring Run in Lancaster, Pennsylvania, legacy sediments now overlay a buried relict hydric soil (a former wetland soil). We compared C and N processing in legacy sediment to upland soils to identify soil zones that may be sources or sinks for N transported toward streams. We hypothesized that legacy sediments would have high nitrification rates (due to recent agricultural N inputs), while relict hydric soils buried beneath the legacy sediments would be N sinks revealed via negative net nitrification and/or positive denitrification (because the buried former wetland soils are C rich but low in O-2). Potential net nitrification ranged from 9.2 to 77.9 g m(-2) year(-1) and potential C mineralization ranged from 223 to 1,737 g m(-2) year(-1), with the highest rates in surface soils for both legacy sediments and uplands. Potential denitrification ranged from 0.37 to 21.72 g m(-2) year(-1), with the buried relict hydric soils denitrifying an average of 6.2 g m(-2) year(-1). Contrary to our hypothesis, relict hydric layers did not have negative potential nitrification or high positive potential denitrification rates, in part because microbial activity was low relative to surface soils, as indicated by low nitrifier population activity, low substrate induced respiration, and low exoenzyme activity. Despite high soil C concentrations, buried relict hydric soils do not provide the ecological services expected from a wetland soil. Thus, legacy sediments may dampen N removal pathways in buried relict hydric soils, while also acting as substantial sources of NO3 (-) to waterways. C1 [Weitzman, Julie N.; Kaye, Jason P.] Penn State Univ, Dept Ecosyst Sci & Management, University Pk, PA 16802 USA. [Forshay, Kenneth J.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74820 USA. [Mayer, Paul M.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Koval, Jason C.] Argonne Natl Lab, Biosci Div, US Dept Energy, Argonne, IL 60439 USA. [Walter, Robert C.] Franklin & Marshall Coll, Dept Earth & Environm, Lancaster, PA 17604 USA. RP Weitzman, JN (reprint author), Penn State Univ, Dept Ecosyst Sci & Management, 116 ASI Bldg, University Pk, PA 16802 USA. EM jnw142@psu.edu RI Forshay, Ken/N-4068-2014; Forshay, Kenneth/P-3649-2015 OI Forshay, Ken/0000-0002-2867-8492; Forshay, Kenneth/0000-0002-2867-8492 FU National Science Foundation [DEB 0816668] FX We thank Dorothy Merritts, Stacey Sosenko, and Michael Rahnis from Franklin and Marshall College, Jeff Hartranft of PA DEP, and Angela Kent from the University of Illinois, who provided assistance in the development of the experimental design and sample collection. We would also like to thank the EPA ORD drilling crew members Ken Jewell and Russell Neil. LiDAR data was provided to the Project by the National Center for Airborne Laser Mapping to Merritts and Walter. This material is based upon work supported by the National Science Foundation under Grant No. DEB 0816668. Notice: The US Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described herein. It has been subject to an administrative review but does not necessarily reflect the views of the Agency. No official endorsement should be inferred. Mention of trade names, products, or services does not convey, and should not be interpreted as conveying, official EPA approval, endorsement, or recommendation. NR 97 TC 1 Z9 1 U1 4 U2 46 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-2563 EI 1573-515X J9 BIOGEOCHEMISTRY JI Biogeochemistry PD AUG PY 2014 VL 120 IS 1-3 BP 337 EP 357 DI 10.1007/s10533-014-0003-1 PG 21 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA AM5BX UT WOS:000339871700021 ER PT J AU Glaser, JA AF Glaser, John A. TI Biocatalyst greenness SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT News Item C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Glaser, JA (reprint author), US EPA, Natl Risk Management Res Lab, 26 W King Dr, Cincinnati, OH 45268 USA. EM glaser.john@epa.gov NR 1 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD AUG PY 2014 VL 16 IS 6 BP 991 EP 999 DI 10.1007/s10098-014-0817-5 PG 9 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AM5CZ UT WOS:000339874900002 ER PT J AU Watson, EB Oczkowski, AJ Wigand, C Hanson, AR Davey, EW Crosby, SC Johnson, RL Andrews, HM AF Watson, E. B. Oczkowski, A. J. Wigand, C. Hanson, A. R. Davey, E. W. Crosby, S. C. Johnson, R. L. Andrews, H. M. TI Nutrient enrichment and precipitation changes do not enhance resiliency of salt marshes to sea level rise in the Northeastern U.S. SO CLIMATIC CHANGE LA English DT Article ID NEW-ENGLAND; SEDIMENT DELIVERY; CHESAPEAKE BAY; UNITED-STATES; EUTROPHICATION; ACCRETION; RESPONSES; IMPACTS AB In the Northeastern U.S., salt marsh area is in decline. Habitat change analysis has revealed fragmentation, displacement of high marsh by low marsh species, and marsh drowning, while development of adjacent uplands limits upslope migration. Measures of marsh vegetation loss for eight sites in Rhode Island and New York between ca.1970 and 2011 indicate that substantial loss has occurred over past decades, with higher loss rates found for lower elevation salt marshes. Using inundation experiments, field surveys, and LiDAR datasets, we developed an elevation-productivity relationship for Spartina alterniflora specific to the U.S. Northeast, and located current salt marsh orthometric heights on this curve. We estimate that 87 % of Northeastern salt marshes are located at elevations where growth is limited by inundation. By manipulating water column nutrients, precipitation, and elevation, we further found that altered precipitation regime was associated with significant reductions in biomass, and that nutrient enrichment adversely impacts organic matter accumulation and peat formation. These results provide evidence that Northeastern U.S. marshes are vulnerable to the effects of accelerated sea level rise, and that neither precipitation changes, nor cultural eutrophication, will contribute positively to long-term salt marsh survival. C1 [Watson, E. B.; Oczkowski, A. J.; Wigand, C.; Hanson, A. R.; Davey, E. W.; Johnson, R. L.] US EPA, Atlantic Ecol Div, ORD NHEERL, Narragansett, RI 02882 USA. [Crosby, S. C.] Brown Univ, Dept Ecol & Evolutionary Biol, Providence, RI 02912 USA. [Andrews, H. M.] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA. RP Watson, EB (reprint author), US EPA, Atlantic Ecol Div, ORD NHEERL, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM elizabeth.b.watson@gmail.com FU U.S. Environmental Protection Agency FX This report is tracking number ORD-005205 of the U.S. EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division. Although the information in this document has been funded by the U.S. Environmental Protection Agency, it does not necessarily reflect the views of the Agency and no official endorsement should be inferred We acknowledge the NBNERR for access to field sites, and for sharing equipment, resources, and data. NR 28 TC 16 Z9 16 U1 3 U2 72 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD AUG PY 2014 VL 125 IS 3-4 BP 501 EP 509 DI 10.1007/s10584-014-1189-x PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AM6JM UT WOS:000339970700016 ER PT J AU Birch, RJ Bigler, J Rogers, JW Zhuang, Y Clickner, RP AF Birch, Rebecca Jeffries Bigler, Jeff Rogers, John W. Zhuang, Yan Clickner, Robert P. TI Trends in blood mercury concentrations and fish consumption among US women of reproductive age, NHANES, 1999-2010 SO ENVIRONMENTAL RESEARCH LA English DT Article DE Blood mercury; Fish consumption; Exposure; Women of reproductive age; NHANES ID METHYLMERCURY EXPOSURE; TRADE-OFFS; HEALTH; BENEFITS; RISKS AB Background: Consumption of finfish and shellfish is the primary exposure pathway of methylmercury (MeHg) in the US. MeHg exposure in utero is associated with neurodevelopmental and motor function deficits. Regulations and fish advisories may contribute to decreased exposure to mercury over time. Objectives: Combine fish tissue mercury (FTHg) concentrations and 1999-2010 NHANES blood mercury concentrations and fish consumption data to investigate trends in blood mercury concentrations, fish consumption, and mercury intake in women of reproductive age. Methods: Blood MeHg was calculated from the blood total and inorganic concentrations. Dietary datasets were combined to estimate 30-day fish consumption, then combined with FTHg concentrations to estimate mercury intake and mercury concentration in the fish consumed. Non-linear and logistic regression analyses were used to evaluate trends over time. Results: Regression analysis found NHANES 1999-2000 to have higher blood MeHg concentrations than the mean of the later releases (p < 0.0001) and a positive quadratic trend since 2000 (p=0.004). No trend was observed in fish consumption amount or mercury intake. A decreasing trend was found in the ratio of mercury intake to fish consumed (p=0.04). Conclusions: The analyses found blood MeHg concentrations in NHANES 1999-2000 to be significantly higher than the mean of the later releases. There was no trend in fish consumption amount across the study period. The analysis found a decreasing trend in the ratio of mercury intake to fish consumed, consistent with women shifting their consumption to fish with lower mercury concentrations. (C) 2014 Elsevier Inc. All rights reserved. C1 [Birch, Rebecca Jeffries; Rogers, John W.; Zhuang, Yan; Clickner, Robert P.] WESTAT Corp, Rockville, MD 20850 USA. [Bigler, Jeff] US EPA, Off Sci & Technol, Off Water, Washington, DC 20460 USA. RP Birch, RJ (reprint author), WESTAT Corp, Rockville, MD 20850 USA. EM RebeccaBirch@Westat.com NR 31 TC 15 Z9 15 U1 2 U2 23 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD AUG PY 2014 VL 133 BP 431 EP 438 DI 10.1016/j.envres.2014.02.001 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AM2UI UT WOS:000339705900054 PM 24602558 ER PT J AU Jolliet, O Frischknecht, R Bare, J Boulay, AM Bulle, C Fantke, P Gheewala, S Hauschild, M Itsubo, N Margni, M McKone, TE Canals, LMY Posthuma, L Prado-Lopez, V Ridoutt, B Sonnemann, G Rosenbaum, RK Seager, T Struijs, J van Zelm, R Vigon, B Weisbrod, A AF Jolliet, Olivier Frischknecht, Rolf Bare, Jane Boulay, Anne-Marie Bulle, Cecile Fantke, Peter Gheewala, Shabbir Hauschild, Michael Itsubo, Norihiro Margni, Manuele McKone, Thomas E. Mila y Canals, Llorenc Posthuma, Leo Prado-Lopez, Valentina Ridoutt, Brad Sonnemann, Guido Rosenbaum, Ralph K. Seager, Tom Struijs, Jaap van Zelm, Rosalie Vigon, Bruce Weisbrod, Annie TI Global guidance on environmental life cycle impact assessment indicators: findings of the scoping phase (vol 19, pg 962, 2014) SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT LA English DT Correction C1 [Jolliet, Olivier] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Frischknecht, Rolf] Treeze Ltd, Uster, Switzerland. [Bare, Jane] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Syst Anal Branch, Cincinnati, OH 45268 USA. [Boulay, Anne-Marie; Bulle, Cecile; Margni, Manuele] Ecole Polytech, CIRAIG, Montreal, PQ H3C 3A7, Canada. [Fantke, Peter; Hauschild, Michael; Rosenbaum, Ralph K.] Tech Univ Denmark, Dept Engn Management, DK-2800 Lyngby, Denmark. [Gheewala, Shabbir] King Mongkuts Univ Technol, Joint Grad Sch Energy & Environm, Thonburi, Thailand. [Itsubo, Norihiro] Tokyo City Univ, Yokohama, Kanagawa, Japan. [McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Mila y Canals, Llorenc] Unilever, Safety & Environm Assurance Ctr, Sharnbrook, Beds, England. [Mila y Canals, Llorenc] United Nations Environm Programme, Div Technol Ind & Econ, Paris, France. [Posthuma, Leo; Struijs, Jaap] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Prado-Lopez, Valentina; Seager, Tom] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA. [Ridoutt, Brad] CSIRO, Sustainable Agr Natl Res Flagship, Clayton, Vic 3168, Australia. [Sonnemann, Guido] Univ Bordeaux, ISM, UMR 5255, Bordeaux, France. [van Zelm, Rosalie] Radboud Univ Nijmegen, Dept Environm Sci, NL-6525 ED Nijmegen, Netherlands. [Vigon, Bruce] SETAC, Pensacola, FL USA. [Weisbrod, Annie] Procter & Gamble Co, Cincinnati, OH USA. RP Jolliet, O (reprint author), Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. EM ojolliet@umich.edu RI van Zelm, Rosalie/D-4108-2011; Ridoutt, Bradley/D-3329-2011 OI Ridoutt, Bradley/0000-0001-7352-0427 NR 1 TC 0 Z9 0 U1 0 U2 25 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0948-3349 EI 1614-7502 J9 INT J LIFE CYCLE ASS JI Int. J. Life Cycle Assess. PD AUG PY 2014 VL 19 IS 8 BP 1566 EP 1566 DI 10.1007/s11367-014-0763-9 PG 1 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AM3CF UT WOS:000339728600010 ER PT J AU Riffle, BW Klinefelter, GR Cooper, RL Winnik, WM Swank, A Jayaraman, S Suarez, J Best, D Laws, SC AF Riffle, Brandy W. Klinefelter, Gary R. Cooper, Ralph L. Winnik, Witold M. Swank, Adam Jayaraman, Saro Suarez, Juan Best, Deborah Laws, Susan C. TI Novel molecular events associated with altered steroidogenesis induced by exposure to atrazine in the intact and castrate male rat SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE Atrazine; Steroidogenesis; Hypothalamic-pituitary-adrenal (HPA) axis; Corticosterone; Proteomics ID PROGESTERONE-BINDING SITE(S); PERIPUBERTAL MALE RATS; MALE WISTAR RATS; PUBERTAL DEVELOPMENT; PESTICIDE EXPOSURE; THYROID-FUNCTION; STRESS-RESPONSE; DRINKING-WATER; ADRENAL-CORTEX; SEMEN QUALITY AB Toxicology is increasingly focused on molecular events comprising adverse outcome pathways. Atrazine activates the hypothalamic-pituitary adrenal axis, but relationships to gonadal alterations are unknown. We characterized hormone profiles and adrenal (intact and castrate) and testis (intact) proteomes in rats after 3 days of exposure. The adrenal accounted for most of the serum progesterone and all of the corticosterone increases in intact and castrated males. Serum luteinizing hormone, androstenedione, and testosterone in intact males shared a non-monotonic response suggesting transition from an acute stimulatory to a latent inhibitory response to exposure. Eight adrenal proteins were significantly altered with dose. There were unique proteomic changes between the adrenals of intact and castrated males. Six testis proteins in intact males had non-monotonic responses that significantly correlated with serum testosterone. Different dose-response curves for steroids and proteins in the adrenal and testis reveal novel adverse outcome pathways in intact and castrated male rats. Published by Elsevier Inc. C1 [Riffle, Brandy W.] Oak Ridge Inst Sci & Educ, Res Participat Program, Oak Ridge, TN 37831 USA. [Klinefelter, Gary R.; Cooper, Ralph L.; Suarez, Juan; Best, Deborah; Laws, Susan C.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Winnik, Witold M.; Swank, Adam] US EPA, Prote Res Core, NHEERL, ORD, Res Triangle Pk, NC 27711 USA. [Jayaraman, Saro] US EPA, Atlantic Ecol Div, NHEERL, ORD, Narragansett, RI 02882 USA. RP Laws, SC (reprint author), US EPA, NHEERL, Tox Assessment Div MD-B105,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM laws.susan@epa.gov FU Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC FX This research was funded entirely by the Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20406. NR 49 TC 3 Z9 3 U1 4 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD AUG PY 2014 VL 47 BP 59 EP 69 DI 10.1016/j.reprotox.2014.05.008 PG 11 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA AM2RE UT WOS:000339697700009 PM 24887032 ER PT J AU Sohn, JA Brooks, JR Bauhus, J Kohler, M Kolb, TE McDowell, NG AF Sohn, Julia A. Brooks, J. Renee Bauhus, Juergen Kohler, Martin Kolb, Thomas E. McDowell, Nathan G. TI Unthinned slow-growing ponderosa pine (Pinus ponderosa) trees contain muted isotopic signals in tree rings as compared to thinned trees SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Oxygen isotopes; Thinning; Pinus ponderosa (ponderosa pine); Gas exchange; Sensitivity analysis ID WATER-USE EFFICIENCY; SPRUCE PICEA-ABIES; MIXED-CONIFER FOREST; PEARSON NATURAL AREA; STAND DENSITY; NORTHERN ARIZONA; GAS-EXCHANGE; BURNING TREATMENTS; CONCEPTUAL-MODEL; DROUGHT RESPONSE AB The muted wood isotopic signal in slow-growing trees of unthinned stands indicates lower responsiveness to changing environmental conditions compared to fast-growing trees in thinned stands. To examine the physiological processes associated with higher growth rates after thinning, we analyzed the oxygen isotopic values in wood (delta O-18(w)) of 12 ponderosa pine (Pinus ponderosa) trees from control, moderately, and heavily thinned stands and compared them with wood-based estimates of carbon isotope discrimination (a dagger C-13), basal area increment (BAI), and gas exchange. We found that (heavy) thinning led to shifts and increased inter-annual variability of both stable carbon and oxygen isotope ratios relative to the control throughout the first post-thinning decade. Results of a sensitivity analysis suggested that both an increase in stomatal conductance (g (s)) and differences in source water among treatments are equally probable causes of the delta O-18(w) shift in heavily thinned stands. We modeled inter-annual changes in delta O-18(w) of trees from all treatments using environmental and physiological data and found that the significant increase in delta O-18(w) inter-annual variance was related to greater delta O-18(w) responsiveness to changing environmental conditions for trees in thinned stands when compared to control stands. Based on model results, the more muted climatic response of wood isotopes in slow-growing control trees is likely to be the consequence of reduced carbon sink strength causing a higher degree of mixing of previously stored and fresh assimilates when compared to faster-growing trees in thinned stands. Alternatively, the muted response of delta O-18(w) to climatic variation of trees in the control stand may result from little variation in the control stand in physiological processes (photosynthesis, transpiration) that are known to affect delta O-18(w). C1 [Sohn, Julia A.; Bauhus, Juergen; Kohler, Martin] Univ Freiburg, Fac Environm & Nat Resources, Chair Silviculture, D-79085 Freiburg, Germany. [Brooks, J. Renee] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Kolb, Thomas E.] No Arizona Univ, Sch Forestry, Flagstaff, AZ 86011 USA. [McDowell, Nathan G.] Los Alamos Natl Lab, Earth & Environm Sci Div, Los Alamos, NM 87545 USA. RP Sohn, JA (reprint author), Univ Freiburg, Fac Environm & Nat Resources, Chair Silviculture, D-79085 Freiburg, Germany. EM julia.sohn@waldbau.uni-freiburg.de RI Bauhus, Jurgen/G-4449-2013; OI Bauhus, Jurgen/0000-0002-9673-4986; Brooks, Renee/0000-0002-5008-9774 FU Deutsche Forschungsgemeinschaft [BA 2821/11-1]; Landesgraduiertenforderung Baden-Wurttemberg; graduate school "Environment, Society and Global Change" at Freiburg University; Wissenschaftliche Gesellschaft Freiburg; Department of Energy, Office of Biological and Environmental Research FX We would like to thank the Deutsche Forschungsgemeinschaft (BA 2821/11-1), the Landesgraduiertenforderung Baden-Wurttemberg, the graduate school "Environment, Society and Global Change" at Freiburg University, and the Wissenschaftliche Gesellschaft Freiburg for their financial support. Many thanks also to Dr. Bernd Kammerer and Erika Fischer of the Center for Biological Systems Analysis (ZBSA) in Freiburg for their help with stable isotope analysis. This manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and it has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This project was also supported by the Department of Energy, Office of Biological and Environmental Research. We thank Lucy Kerhoulas from NAU who assembled and kindly provided the climatic data used in this study. NR 114 TC 5 Z9 5 U1 0 U2 33 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0931-1890 EI 1432-2285 J9 TREES-STRUCT FUNCT JI Trees-Struct. Funct. PD AUG PY 2014 VL 28 IS 4 BP 1035 EP 1051 DI 10.1007/s00468-014-1016-z PG 17 WC Forestry SC Forestry GA AM5EH UT WOS:000339878500008 ER PT J AU Starr, JM Gemma, AA Graham, SE Stout, DM AF Starr, J. M. Gemma, A. A. Graham, S. E. Stout, D. M., II TI A test house study of pesticides and pesticide degradation products following an indoor application SO INDOOR AIR LA English DT Article DE Pyrethroids; Fipronil; Propoxur; Indoor; Degradation ID PRESCHOOL-CHILDREN; DAY-CARE; METABOLITES; FIPRONIL; EXPOSURE; CHLORPYRIFOS; DUST; 3,5,6-TRICHLORO-2-PYRIDINOL; QUANTIFICATION; ENVIRONMENTS AB Preexisting pesticide degradates are a concern for pesticide biomonitoring studies as exposure to them may result in overestimation of pesticide exposure. The purpose of this research was to determine whether there was significant formation and movement, of pesticide degradates over a 5-week period in a controlled indoor setting after insecticide application. Movement of the pesticides during the study was also evaluated. In a simulated crack and crevice application, commercially available formulations of fipronil, propoxur, cis/trans-permethrin, and cypermethrin were applied to a series of wooden slats affixed to the wall in one room of an unoccupied test house. Floor surface samples were collected through 35 days post-application. Concentrations of the pesticides and the following degradates were determined: 2-iso-propoxyphenol, cis/trans 3-(2,2-dichlorovinyl)-3-3-dimethyl-(1-cyclopropane) carboxylic acid, 3-phenoxybenzoic acid, fipronil sulfone, fipronil sulfide, and fipronil desulfinyl. Deltamethrin, which had never been applied, and chlorpyrifos, which had been applied several years earlier, and their degradation products, cis-3-(2,2-dibromovinyl)- 2,2-dimethylcyclopropane-1-carboxylic acid, and, 3,5,6-trichloro- 2-pyridinol, respectively, were also measured. Propoxur was the only insecticide with mass movement away from the application site. There was no measurable formation or movement of the degradates. However, all degradates were present at low levels in the formulated product. These results indicate longitudinal repetitive sampling of indoor degradate levels during short-term studies, is unnecessary. C1 [Starr, J. M.; Stout, D. M., II] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Gemma, A. A.] Natl Caucus, Washington, DC USA. [Gemma, A. A.] Ctr Black Aged SEE Program, Washington, DC USA. [Graham, S. E.] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Starr, JM (reprint author), US EPA, MD D205-05,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM starr.james@epa.gov FU The United States Environmental Protection Agency through its Office of Research and Development FX This work was supported by The United States Environmental Protection Agency through its Office of Research and Development who funded and managed the research described here. It has been subjected to Agency administrative review and approved for publication. This does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 33 TC 5 Z9 5 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0905-6947 EI 1600-0668 J9 INDOOR AIR JI Indoor Air PD AUG PY 2014 VL 24 IS 4 BP 390 EP 402 DI 10.1111/ina.12093 PG 13 WC Construction & Building Technology; Engineering, Environmental; Public, Environmental & Occupational Health SC Construction & Building Technology; Engineering; Public, Environmental & Occupational Health GA AM1OV UT WOS:000339617900006 PM 24387593 ER PT J AU Gilbert, ME Ramos, RL McCloskey, DP Goodman, JH AF Gilbert, M. E. Ramos, R. L. McCloskey, D. P. Goodman, J. H. TI Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics SO JOURNAL OF NEUROENDOCRINOLOGY LA English DT Article DE hypothyroxinaemia; foetal brain; neuronal migration; thyroid hormone propylthiouracil ID THYROID-HORMONE INSUFFICIENCY; PROPYLTHIOURACIL-INDUCED HYPOTHYROIDISM; IMPAIRS SYNAPTIC-TRANSMISSION; CEREBRAL-CORTEX; DEVELOPMENTAL EXPOSURE; IODINE DEFICIENCY; BRAIN-DEVELOPMENT; DENTATE GYRUS; ADULT-RATS; NEUROPSYCHOLOGICAL DEVELOPMENT AB Thyroid hormones (TH) play crucial roles in brain maturation and are important for neuronal migration and neocortical lamination. Subcortical band heterotopia (SBH) represent a class of neuronal migration errors in humans that are often associated with childhood epilepsy. We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU). In the present study, we report the dose-response characteristics of this developmental malformation and the connectivity of heterotopic neurones with other brain regions, as well as their functionality. Pregnant rats were exposed to varying concentrations of PTU through the drinking water (0-10 p. p. m.) beginning on gestational day 6 to produce graded levels of TH insufficiency. Dose-dependent increases in the volume of the SBH present in the corpus callosum were documented in the adult offspring, with a clear presence at concentrations of PTU that resulted in minor (< 15%) reductions in maternal serum thyroxine as measured when pups were weaned. SBH contain neurones, oligo-dendrocytes, astrocytes and microglia. Monoaminergic and cholinergic processes were prevalent and many of the axons were myelinated. Anatomical connectivity of SBH neurones to cortical neurones and the synaptic functionality of these anatomical connections was verified by ex vivo field potential recordings. SBH persisted in adult offspring despite a return to euthyroid status on termination of exposure and these offspring displayed an increased sensitivity to seizures. Features of this model are attractive with respect to the investigation of the molecular mechanisms of cortical development, the effectiveness of therapeutic intervention in hypothyroxinaemia during pregnancy and the impact of the very modest TH imbalance that accompanies exposure to environmental contaminants. C1 [Gilbert, M. E.] US EPA, Tox Assessment Div, Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA. [Ramos, R. L.] New York Inst Technol, Coll Osteopath Med, Dept Biomed Sci, Old Westbury, NY 11568 USA. [McCloskey, D. P.] CUNY Coll Staten Isl, Dept Psychol, Staten Isl, NY USA. [McCloskey, D. P.] CUNY Coll Staten Isl, Program Dev Neurosci, Staten Isl, NY USA. [Goodman, J. H.] NY State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, Staten Isl, NY USA. [Goodman, J. H.] Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA. [Goodman, J. H.] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA. RP Gilbert, ME (reprint author), US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, MD B105-05, Res Triangle Pk, NC 27711 USA. EM gilbert.mary@epa.gov NR 101 TC 10 Z9 10 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0953-8194 EI 1365-2826 J9 J NEUROENDOCRINOL JI J. Neuroendocrinol. PD AUG PY 2014 VL 26 IS 8 BP 528 EP 541 DI 10.1111/jne.12169 PG 14 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA AL9TN UT WOS:000339484600006 PM 24889016 ER PT J AU White, CP Popovici, J Lytle, DA Rice, EW AF White, Colin P. Popovici, Jonathan Lytle, Darren A. Rice, Eugene W. TI Endospore surface properties of commonly used Bacillus anthracis surrogates vary in aqueous solution SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY LA English DT Article DE Anthrax; Endospores; Hydrophobicity; Electrophoretic mobility; Surface; Surrogate ID ELECTROPHORETIC MOBILITY; CEREUS SPORES; BACTERIAL ADHESION; STAINLESS-STEEL; HYDROPHOBICITY; EXOSPORIUM; WATER; HYDROCARBONS; GERMINATION; ATROPHAEUS AB The hydrophobic character and electrophoretic mobility (EPM) of microorganisms are vital aspects of understanding their interactions with the environment. These properties are fundamental in fate-and-transport, physiological, and virulence studies, and thus integral in surrogate selection. Hydrophobic and electrostatic forces are significant contributors to particle and microorganism mobility in the environment. Herein, the surface properties of commonly used Bacillus anthracis surrogate endospores were tested under comparable conditions with respect to culture, endospore purification, buffer type and strength. Additionally, data is presented of endospores suspended in dechlorinated tap water to evaluate the surrogates in regard to a breach of water infrastructure security. The surface properties of B. anthracis were found to be the most hydrophobic and least electronegative among the six Bacillus species tested across buffer strength. The effect of EPM on hydrophobicity varies in a species-specific manner. This study demonstrates that surrogate surface properties differ and care must be taken when choosing the most suitable surrogate. Moreover, it is shown that Bacillus thuringensis best represents Bacillus anthracis-Sterne with respect to both EPM and hydrophobicity across all test buffers. C1 [White, Colin P.] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Popovici, Jonathan] Univ Cincinnati, Cincinnati, OH 45221 USA. [Lytle, Darren A.] US EPA, ORD, NRMRL, WSWRD, Cincinnati, OH 45268 USA. [Rice, Eugene W.] US EPA, ORD, NHSRC, WIPD, Cincinnati, OH 45268 USA. RP White, CP (reprint author), Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. EM white.colin@epa.gov FU U.S. Environmental Protection Agency through Office of Research and Development FX The authors would like to thank Noreen Adcock and Amanda Jennings for assistance with spore preparation and Emily Nauman of Pegasus Technical Services for editorial comments. The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein. It has been subjected to the Agency's peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 48 TC 1 Z9 1 U1 1 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0003-6072 EI 1572-9699 J9 ANTON LEEUW INT J G JI Antonie Van Leeuwenhoek PD AUG PY 2014 VL 106 IS 2 BP 243 EP 251 DI 10.1007/s10482-014-0187-3 PG 9 WC Microbiology SC Microbiology GA AL8FT UT WOS:000339374100007 PM 24817579 ER PT J AU Williams, RL Wakeham, S McKinney, R Wishner, KF AF Williams, Rebecca L. Wakeham, Stuart McKinney, Rick Wishner, Karen F. TI Trophic ecology and vertical patterns of carbon and nitrogen stable isotopes in zooplankton from oxygen minimum zone regions SO DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS LA English DT Article DE Stable isotopes; delta N-15; delta C-13; Zooplankton; Trophic ecology; Eastern Tropical North Pacific; Oxygen minimum zone; Costa Rica Dome ID EASTERN TROPICAL PACIFIC; PARTICULATE ORGANIC-MATTER; FOOD-WEB STRUCTURE; ARABIAN SEA; NORTH PACIFIC; SOUTHERN-OCEAN; CARIACO BASIN; WATER COLUMN; MESOZOOPLANKTON BIOMASS; METABOLIC SUPPRESSION AB The unique physical and biogeochemical characteristics of oxygen minimum zones (OMZs) influence plankton ecology, including zooplankton trophic webs. Using carbon and nitrogen stable isotopes, this study examined zooplankton trophic webs in the Eastern Tropical North Pacific (ETNP) OMZ. delta C-13 values were used to indicate zooplankton food sources, and delta N-15 values were used to indicate zooplankton trophic position and nitrogen cycle pathways. Vertically stratified MOCNESS net tows collected zooplankton from 0 to 1000 m at two stations along a north-south transect in the ETNP during 2007 and 2008, the Tehuantepec Bowl and the Costa Rica Dome. Zooplankton samples were separated into four size fractions for stable isotope analyses. Particulate organic matter (POM), assumed to represent a primary food source for zooplankton, was collected with McLane large volume in situ pumps. The isotopic composition and trophic ecology of the ETNP zooplankton community had distinct spatial and vertical patterns influenced by OMZ structure. The most pronounced vertical isotope gradients occurred near the upper and lower OMZ oxyclines. Material with lower delta C-13 values was apparently produced in the upper oxycline, possibly by chemoautotrophic microbes, and was subsequently consumed by zooplankton. Between-station differences in delta N-15 values suggested that different nitrogen cycle processes were dominant at the two locations, which influenced the isotopic characteristics of the zooplankton community. A strong depth gradient in zooplankton delta N-15 values in the lower oxycline suggested an increase in trophic cycling just below the core of the OMZ. Shallow POM (0110 m) was likely the most important food source for mixed layer, upper oxycline, and OMZ core zooplankton, while deep POM was an important food source for most lower oxycline zooplankton (except for samples dominated by the seasonally migrating copepod Eucalanus inermis). There was no consistent isotopic progression among the four zooplankton size classes for these bulk mixed assemblage samples, implying overlapping trophic webs within the total size range considered. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Williams, Rebecca L.; Wishner, Karen F.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. [Wakeham, Stuart] Skidaway Inst Oceanog, Savannah, GA 31411 USA. [McKinney, Rick] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Wishner, KF (reprint author), Univ Rhode Isl, Grad Sch Oceanog, 215 South Ferry Rd, Narragansett, RI 02882 USA. EM kwishner@mail.uri.edu FU NSF [OCE0526502, OCE0550654, OCE526545]; University of Rhode Island funding FX We thank the captain, crews, and marine technicians aboard the R.V. Seward Johnson and R.V. Knorr. We thank our formal collaborators, K. Daly (chief scientist) and B. Seibel, along with colleagues R. Sambrotto, G. Taylor, and C. Flagg and their students and postdocs for their help and discussions. We thank the United States Environmental Protection Agency Atlantic Ecology Division for providing the use of their mass spectrometer, and J. Brandes, M. Cantwell, A. Oczkowski, and M. Richards for assistance with stable isotope analysis. We thank D. Outram for extensive help both at sea and in the lab, B. Olsen for providing phytoplankton species assemblage data, K. Fanning for providing nutrient data, and R. Robinson for assisting with interpretation of nitrogen source inputs. Finally, we thank C. Cass, N. Charriere, A. Cleary, J. Graff, A. Maas, M. McNamara, M. O'Brien, B. Olsen, B. Phillips, and A. Remsen, who assisted with sample collections and cruise logistics. This research, part of a collaborative grant with K. Daly and B. Seibel, was supported by NSF grants OCE0526502 (Wishner and Seibel), OCE0550654 (Wakeham), OCE526545 (Daly), and University of Rhode Island funding. NR 87 TC 7 Z9 7 U1 4 U2 51 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0967-0637 EI 1879-0119 J9 DEEP-SEA RES PT I JI Deep-Sea Res. Part I-Oceanogr. Res. Pap. PD AUG PY 2014 VL 90 BP 36 EP 47 DI 10.1016/j.dsr.2014.04.008 PG 12 WC Oceanography SC Oceanography GA AL2TN UT WOS:000338978400004 ER PT J AU Lu, HF Yuan, YG Campbell, DE Qin, P Cui, LJ AF Lu, Hongfang Yuan, Yaguang Campbell, Daniel E. Qin, Pei Cui, Lijuan TI Integrated water quality, emergy and economic evaluation of three bioremediation treatment systems for eutrophic water SO ECOLOGICAL ENGINEERING LA English DT Article DE Eutrophic lakes; Bioremediation treatment systems; Integrated evaluation; Emergy; Water quality; Economics ID SUSTAINABILITY; CHINA; LAKE; WETLAND; ENERGY; CONTAMINANT; ELECTRICITY; RETENTION; SEDIMENTS; INDEXES AB This study was targeted at finding one or more environmentally efficient, economically feasible and ecologically sustainable bioremediation treatment modes for eutrophic water. Three biological species, i.e. water spinach (Ipomoea aquatica), loach (Misgurus anguillicaudatus) and a pseudomonad (Rhodopseu-domonas palustris), were combined in different ways: (A) water spinach-loach-pseudomonad; (B) water spinach-loach; (C) water spinach-pseudomonad, to construct three ecological engineering systems targeted at removing nutrients from the eutrophic water of Taihu Lake, PR China. An integrated water quality, emergy and economic evaluation of the three treatment systems was performed based on the observed changes in biomass, water quality, and other natural and economic inputs and outputs. The three ecological engineering treatment systems showed a different order of efficiency in removing nutrients (treatment A > B > C), produced different environmental loadings at the foreground (treatment B > C > A), background (treatment C = A > B) and whole system scales (treatment C > A > B), and had different economic feasibility (treatment B > A > C). Finally, after taking all direct and indirect environmental and economic impacts into account, treatment A was found to be the best choice at the foreground scale, followed by treatment C and then B, while at the background and whole system scales, treatment B was the best option followed by A and C. In this analysis, emergy evaluation was found to be an ideal ecological integration tool for quantifying both the environmental and economic characteristics of ecological engineering systems and processes at multiple scales, including pollution treatment systems. The complex results of this study obtained by considering water treatment efficiency, emergy indices of sustainability and loading on multiple scales besides economic output/input analysis can inform decision-makers about trade-offs that confront them in the management of eutrophic waters. (C) 2014 Elsevier B.V. All rights reserved. C1 [Lu, Hongfang] Chinese Acad Sci, South China Bot Garden, Key Lab Vegetat Restorat & Management Degraded Ec, Guangzhou 510650, Guangdong, Peoples R China. [Yuan, Yaguang; Qin, Pei] Nanjing Univ, Sch Life Sci, Halophyte Res Lab, Nanjing 210093, Jiangsu, Peoples R China. [Campbell, Daniel E.] US EPA, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA. [Cui, Lijuan] Chinese Acad Forestry, Inst Wetland Res, Beijing 100091, Peoples R China. RP Qin, P (reprint author), 22 Hankou Rd, Nanjing 510650, Jiangsu, Peoples R China. EM qinpei@nju.edu.cn; lkyclj@126.com FU National Forestry Commonweal Project of China [200904001]; National Natural Science Foundation of China [31170428] FX This study is supported by National Forestry Commonweal Project of China (200904001), and the National Natural Science Foundation of China (31170428). Although the USEPA contributed to this article, the research presented was not subject to the EPA review system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent USEPA views or policies. We would like to thank the anonymous reviewers for very helpful comments and suggestions of the manuscript. NR 61 TC 7 Z9 10 U1 4 U2 54 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 EI 1872-6992 J9 ECOL ENG JI Ecol. Eng. PD AUG PY 2014 VL 69 BP 244 EP 254 DI 10.1016/j.ecoleng.2014.04.024 PG 11 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA AL2AM UT WOS:000338928200032 ER PT J AU Christensen, KLY Makris, SL Lorber, M AF Christensen, Krista L. Y. Makris, Susan L. Lorber, Matthew TI Generation of hazard indices for cumulative exposure to phthalates for use in cumulative risk assessment SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Phthalates; Exposure; Cumulative risk ID N-BUTYL PHTHALATE; REPRODUCTIVE DEVELOPMENT; DIISOBUTYL PHTHALATE; DI(2-ETHYLHEXYL)PHTHALATE DEHP; CREATININE CONCENTRATIONS; TESTOSTERONE PRODUCTION; DEVELOPMENTAL TOXICITY; TEMPORAL VARIABILITY; DIETARY EXPOSURE; BISPHENOL-A AB Exposures to multiple chemicals may contribute to increased risk of similar adverse effects. Cumulative risk may be estimated using a hazard index (HI), the sum of individual hazard quotients (HQ ratio of exposure to the reference value). We demonstrate the HI approach for five phthalates: di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP), diisobutyl phthalate (DiBP), diisononyl phthalate (DiNP), and butyl benzyl phthalate (BBP). Phthalate exposure for the US general population is estimated using urine metabolite levels from NHANES, extrapolating to ingested 'dose' using the creatinine correction approach. We used two sets of reference values: European Union Tolerable Daily Intakes and Denmark Environmental Protection Agency Derived No Effect Levels. We also investigated the use of an alternate reference value for DEHP, derived from a recent study on male reproductive system development. HQs and His were calculated for the total population ages 6 years and older, as well as for men and women of approximate reproductive age (18-39 years), and children (6-11 years). Median HQs ranged from <0.01 for BBP, to similar to 0.1 (using established values) or similar to 2 (using an alternate value) for DEHP. Median His were <0.30 (95th percentiles just >1.0), and were driven by DEHP and DBP exposures. Published by Elsevier Inc. C1 [Christensen, Krista L. Y.; Makris, Susan L.; Lorber, Matthew] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC USA. RP Christensen, KLY (reprint author), Mailstop 8623P,1200 Penn Ave NW, Washington, DC 20460 USA. EM Christensen.Krista@epa.gov NR 74 TC 10 Z9 10 U1 1 U2 22 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD AUG PY 2014 VL 69 IS 3 BP 380 EP 389 DI 10.1016/j.yrtph.2014.04.019 PG 10 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AL4SZ UT WOS:000339126400012 PM 24815596 ER PT J AU Phillips, MB Sobus, JR George, BJ Isaacs, K Conolly, R Tan, YM AF Phillips, Martin B. Sobus, Jon R. George, Barbara J. Isaacs, Kristin Conolly, Rory Tan, Yu-Mei TI A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Biomarker; Biomonitoring; Biomonitoring equivalent; Prioritization; NHANES; PBPK; Perchlorate; Urine ID RISK-ASSESSMENT CONTEXT; PHARMACOKINETIC MODEL; DIETARY-INTAKE; PERCHLORATE; POPULATION; INHIBITION; KINETICS; HUMANS AB Biomonitoring data are now available for hundreds of chemicals through state and national health surveys. Exposure guidance values also exist for many of these chemicals. Several methods are frequently used to evaluate biomarker data with respect to a guidance value. The "biomonitoring equivalent" (BE) approach estimates a single biomarker concentration (called the BE) that corresponds to a guidance value (e.g., Maximum Contaminant Level, Reference Dose, etc.), which can then be compared with measured biomarker data. The resulting "hazard quotient" estimates (HQ = biomarker concentration/BE) can then be used to prioritize chemicals for follow-up examinations. This approach is used exclusively for population-level assessments, and works best when the central tendency of measurement data is considered. Complementary approaches are therefore needed for assessing individual biomarker levels, particularly those that fall within the upper percentiles of measurement distributions. In this case study, probabilistic models were first used to generate distributions of BEs for perchlorate based on the point-of-departure (POD) of 7 mu g/kg/day. These distributions reflect possible biomarker concentrations in a hypothetical population where all individuals are exposed at the POD. A statistical analysis was then performed to evaluate urinary perchlorate measurements from adults in the 2001 to 2002 National Health and Nutrition Examination Survey (NHANES). Each NHANES adult was assumed to have experienced repeated exposure at the POD, and their biomarker concentration was interpreted probabilistically with respect to a BE distribution. The HQ based on the geometric mean (GM) urinary perchlorate concentration was estimated to be much lower than unity (HQ approximate to 0.07). This result suggests that the average NHANES adult was exposed to perchlorate at a level well below the POD. Regarding individuals, at least a 99.8% probability was calculated for all but two NHANES adults that a higher biomarker concentration would have been observed compared to what was actually measured if the daily dietary exposure had been at the POD. This is strong evidence that individual perchlorate exposures in the 2001-2002 NHANES adult population were likely well below the POD. This case study demonstrates that the "stochastic BE approach" provides useful quantitative metrics, in addition to HQ estimates, for comparison across chemicals. This methodology should be considered when evaluating biomarker measurements against exposure guidance values, and when examining chemicals that have been identified as needing follow-up investigation based on existing HQ estimates. Published by Elsevier Inc. C1 [Phillips, Martin B.; Sobus, Jon R.; Isaacs, Kristin; Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [George, Barbara J.; Conolly, Rory] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. RP Tan, YM (reprint author), 109 TW Alexander Dr,Mail Code E205-01, Res Triangle Pk, NC 27709 USA. EM phillips.martin@epa.gov; sobus.jon@epa.gov; george.bj@epa.gov; isaacs.kristin@epa.gov; rory@epa.gov; tan.cecilia@epa.gov OI Phillips, Martin/0000-0002-6282-529X NR 38 TC 3 Z9 3 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD AUG PY 2014 VL 69 IS 3 BP 434 EP 442 DI 10.1016/j.yrtph.2014.05.008 PG 9 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AL4SZ UT WOS:000339126400018 PM 24845241 ER PT J AU Frazier, MR Lamberson, JO Nelson, WG AF Frazier, Melanie R. Lamberson, Janet O. Nelson, Walter G. TI Intertidal habitat utilization patterns of birds in a Northeast Pacific estuary SO WETLANDS ECOLOGY AND MANAGEMENT LA English DT Article DE Estuary; Bird; Seagrass; Eelgrass; Intertidal; Pacific Northwest ID ECOSYSTEM SERVICES; ZOSTERA-JAPONICA; BRITISH-COLUMBIA; DABBLING DUCKS; BOUNDARY BAY; BLACK BRANT; CONSERVATION; ASSOCIATIONS; WASHINGTON; ABUNDANCE AB A habitat-based framework is a practical method for developing models (or, ecological production functions, EPFs) to describe the spatial distribution of ecosystem services. To generate EPFs for Yaquina estuary, Oregon, USA, we compared bird use patterns among intertidal habitats. Visual censuses were used to quantify abundance of bird groups and general species richness in: Zostera marina (eelgrass), Upogebia (mud shrimp)/mudflat, Neotrypaea (ghost shrimp)/sandflat, Zostera japonica (Japanese eelgrass), and low marsh estuarine habitats. Also assessed were (1) spatial variation within a habitat along the estuary gradient and, (2) temporal variation based on bi-monthly samples over a year at five tidal ranges. Z. marina was an important estuarine habitat based on nearly all metrics of bird use, except for shorebird densities. This suggests that reductions in native eelgrass habitat may reduce the abundance and diversity of birds in Yaquina estuary. Our results suggest that a habitat based assessment approach is generally feasible for developing relative EPFs related to the presence of birds within estuarine systems. C1 [Frazier, Melanie R.; Lamberson, Janet O.; Nelson, Walter G.] US EPA, Off Res & Dev, Western Ecol Div, Newport, OR 97365 USA. RP Frazier, MR (reprint author), Natl Ctr Ecol Anal & Synth, Santa Barbara, CA 93101 USA. EM frazier@nceas.ucsb.edu FU U.S. Environmental Protection Agency FX The authors thank Drs. Rick McKinney, Wayne Hoffman, and Robert Ozretich for discussion in the formative stages of this project. Drs. McKinney and Ozretich also provided helpful comments on the draft manuscript. Pat Clinton provided GIS habitat maps based on research efforts of many colleagues at EPA. Karen Ebert and Marianne Colvin assisted with manuscript production. Melanie Frazier was supported by a U.S. Environmental Protection Agency postdoctoral fellowship. The information in this document has been funded wholly or in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 57 TC 2 Z9 2 U1 8 U2 41 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0923-4861 EI 1572-9834 J9 WETL ECOL MANAG JI Wetl. Ecol. Manag. PD AUG PY 2014 VL 22 IS 4 BP 451 EP 466 DI 10.1007/s11273-014-9346-6 PG 16 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AL8HQ UT WOS:000339379400008 ER PT J AU Schwede, DB Lear, GG AF Schwede, Donna B. Lear, Gary G. TI A novel hybrid approach for estimating total deposition in the United States SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Atmospheric deposition; Nitrogen budget; Sulfur budget; Critical loads; Hybrid model ID ATMOSPHERIC NITROGEN DEPOSITION; HARMFUL ALGAL BLOOMS; CMAQ MODELING SYSTEM; EUTROPHICATION; ECOSYSTEM; CYCLE AB Atmospheric deposition of nitrogen and sulfur causes many deleterious effects on ecosystems including acidification and excess eutrophication. Assessments to support development of strategies to mitigate these effects require spatially and temporally continuous values of nitrogen and sulfur deposition. In the U.S., national monitoring networks exist that provide values of wet and dry deposition at discrete locations. While wet deposition can be interpolated between the monitoring locations, dry deposition cannot. Additionally, monitoring networks do not measure the complete suite of chemicals that contribute to total sulfur and nitrogen deposition. Regional air quality models provide spatially continuous values of deposition of monitored species as well as important unmeasured species. However, air quality modeling values are not generally available for an extended continuous time period. Air quality modeling results may also be biased for some chemical species. We developed a novel approach for estimating dry deposition using data from monitoring networks such as the Clean Air Status and Trends Network (CASTNET), the National Atmospheric Deposition Program (NADP) Ammonia Monitoring Network (AMoN), and the Southeastern Aerosol Research and Characterization (SEARCH) network and modeled data from the Community Multiscale Air Quality (CMAQ) model. These dry deposition values estimates are then combined with wet deposition values from the NADP National Trends Network (NTN) to develop values of total deposition of sulfur and nitrogen. Data developed using this method are made available via the CASTNET website. Published by Elsevier Ltd. C1 [Schwede, Donna B.] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. [Lear, Gary G.] US EPA, Off Atmospher Programs, Clean Air Markets Div, Res Triangle Pk, NC 27711 USA. RP Schwede, DB (reprint author), US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, MD-E243-02, Res Triangle Pk, NC 27711 USA. EM Schwede.donna@epa.gov NR 40 TC 19 Z9 20 U1 5 U2 39 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD AUG PY 2014 VL 92 BP 207 EP 220 DI 10.1016/j.atmosenv.2014.04.008 PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AL0IO UT WOS:000338810800024 ER PT J AU Flynn, CM Pickering, KE Crawford, JH Lamsal, L Krotkov, N Herman, J Weinheimer, A Chen, G Liu, X Szykman, J Tsay, SC Loughner, C Hains, J Lee, P Dickerson, RR Stehr, JW Brent, L AF Flynn, Clare M. Pickering, Kenneth E. Crawford, James H. Lamsal, Lok Krotkov, Nickolay Herman, Jay Weinheimer, Andrew Chen, Gao Liu, Xiong Szykman, James Tsay, Si-Chee Loughner, Christopher Hains, Jennifer Lee, Pius Dickerson, Russell R. Stehr, Jeffrey W. Brent, Lacey TI Relationship between column-density and surface mixing ratio: Statistical analysis of O-3 and NO2 data from the July 2011 Maryland DISCOVER-AQ mission SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Ozone; Nitrogen oxides; DISCOVER-AQ; Column-surface relationship; Aircraft measurement campaign; Measurement-model comparison ID TROPOSPHERIC OZONE; AIR-POLLUTANTS; UNITED-STATES; PART I; MODEL; SATELLITE; POLLUTION; LAYER; OMI AB To investigate the ability of column (or partial column) information to represent surface air quality, results of linear regression analyses between surface mixing ratio data and column abundances for O-3 and NO2 are presented for the July 2011 Maryland deployment of the DISCOVER-AQ mission. Data collected by the P-3B aircraft, ground-based Pandora spectrometers, Aura/OMI satellite instrument, and simulations for July 2011 from the CMAQ air quality model during this deployment provide a large and varied data set, allowing this problem to be approached from multiple perspectives. O-3 columns typically exhibited a statistically significant and high degree of correlation with surface data (R-2 > 0.64) in the P-3B data set, a moderate degree of correlation (0.16 < R-2 < 0.64) in the CMAQ data set, and a low degree of correlation (R-2 < 0.16) in the Pandora and OMI data sets. NO2 columns typically exhibited a low to moderate degree of correlation with surface data in each data set. The results of linear regression analyses for O-3 exhibited smaller errors relative to the observations than NO2 regressions. These results suggest that O-3 partial column observations from future satellite instruments with sufficient sensitivity to the lower troposphere can be meaningful for surface air quality analysis. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Flynn, Clare M.; Pickering, Kenneth E.; Dickerson, Russell R.; Stehr, Jeffrey W.; Brent, Lacey] Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA. [Pickering, Kenneth E.; Krotkov, Nickolay; Tsay, Si-Chee] NASA Goddard Space Flight Ctr, Greenbelt, MD USA. [Crawford, James H.; Chen, Gao] NASA Langley Res Ctr, Hampton, VA USA. [Lamsal, Lok] NASA Goddard Space Flight Ctr, GESTAR, Greenbelt, MD USA. [Herman, Jay] NASA Goddard Space Flight Ctr, UMBC, Greenbelt, MD USA. [Weinheimer, Andrew] NCAR Atmospher Chem Div, Boulder, CO USA. [Liu, Xiong] Harvard Smithsonian Ctr Astrophys, Cambridge, MA USA. [Szykman, James] EPA, Off Res & Dev, Washington, DC USA. [Loughner, Christopher] NASA Goddard Space Flight Ctr, ESSIC, Greenbelt, MD USA. [Hains, Jennifer] Maryland Dept Environm, Baltimore, MD 21224 USA. [Lee, Pius] NOAA Air Resources Lab, Silver Spring, MD USA. RP Flynn, CM (reprint author), Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA. EM cflynn@atmos.umd.edu RI Liu, Xiong/P-7186-2014; Krotkov, Nickolay/E-1541-2012; Lee, Pius/D-5201-2016; Pickering, Kenneth/E-6274-2012; Dickerson, Russell/F-2857-2010; OI Liu, Xiong/0000-0003-2939-574X; Krotkov, Nickolay/0000-0001-6170-6750; Dickerson, Russell/0000-0003-0206-3083; Herman, Jay/0000-0002-9146-1632; Loughner, Christopher/0000-0002-3833-2014 FU NASA Earth Venture-1 DISCOVER-AQ project [NNX10AR39G] FX Funding for this work was provided by the NASA Earth Venture-1 DISCOVER-AQ project (NASA Grant NNX10AR39G). The authors thank Donald Lenschow for providing estimates of PBL height during the deployment. NR 34 TC 10 Z9 10 U1 4 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD AUG PY 2014 VL 92 BP 429 EP 441 DI 10.1016/j.atmosenv.2014.04.041 PG 13 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AL0IO UT WOS:000338810800045 ER PT J AU Gulson, B Mizon, K Taylor, A Korsch, M Davis, JM Louie, H Wu, M Gomez, L Antin, L AF Gulson, Brian Mizon, Karen Taylor, Alan Korsch, Michael Davis, J. Michael Louie, Honway Wu, Michael Gomez, Laura Antin, Luminita TI Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting SO ENVIRONMENTAL POLLUTION LA English DT Article DE Pb; Mn; Children; Blood; Handwipes; Dust; Soil; Diet; Pathways ID BLOOD LEAD LEVELS; METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL; CONTAMINATED HOUSE-DUST; PSYCHOMOTOR DEVELOPMENT; RISK-ASSESSMENT; NEW-ORLEANS; HAND-LEAD; SOIL LEAD; EXPOSURE; HEALTH AB We monitored 108 children <= 5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n similar to 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 mu g/dL and blood Mn (MnB) was 10.0 mu g/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Gulson, Brian; Mizon, Karen] Macquarie Univ, Fac Sci, Grad Sch Environm, Sydney, NSW 2109, Australia. [Gulson, Brian; Korsch, Michael; Gomez, Laura] CSIRO, Sydney, NSW, Australia. [Taylor, Alan] Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia. [Davis, J. Michael] US EPA, Res Triangle Pk, NC 27711 USA. [Louie, Honway; Wu, Michael; Antin, Luminita] Natl Measurement Inst, Sydney, NSW, Australia. RP Gulson, B (reprint author), Macquarie Univ, Fac Sci, Grad Sch Environm, Sydney, NSW 2109, Australia. EM brian.gulson@mq.edu.au FU Australian Research Council; Commonwealth Scientific and Industrial Research Organisation; National Measurements Institute; US EPA; Macquarie University FX We wish to thank: the parents for allowing participation of their children; Marilyn Morgan for phlebotomy; Becton Dickinson, AstraZeneca, and Johnson & Johnson for consumables for sampling; the NSW Roads and Traffic Authority for allowing access to their traffic data; the Australian Research Council, Commonwealth Scientific and Industrial Research Organisation, the National Measurements Institute, US EPA, and Macquarie University for partial funding of the research. NR 79 TC 8 Z9 8 U1 6 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD AUG PY 2014 VL 191 BP 38 EP 49 DI 10.1016/j.envpol.2014.04.009 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK7JS UT WOS:000338605200006 PM 24792883 ER PT J AU Settimio, L McLaughlin, MJ Kirby, JK Langdon, KA Lombi, E Donner, E Scheckel, KG AF Settimio, Lara McLaughlin, Mike J. Kirby, Jason K. Langdon, Kate A. Lombi, Enzo Donner, Erica Scheckel, Kirk G. TI Fate and lability of silver in soils: Effect of ageing SO ENVIRONMENTAL POLLUTION LA English DT Article DE Silver; Lability; Speciation; Ageing ID SEWAGE-SLUDGE; WASTE-WATER; ISOTOPIC DILUTION; AG NANOPARTICLES; ORGANIC-MATTER; SPECIATION; TOXICITY; METAL; BEHAVIOR; SORPTION AB The fate and lability of added soluble Ag in soils over time was examined by measurement of labile metal (E-value) by isotopic dilution using the Ag-110 radioactive isotope and the solid-phase speciation of Ag by X-ray absorption near edge structure (XANES) spectroscopy. After two weeks of ageing the E-values for Ag decreased by 20-90% with a further decrease of 10-40% after six months. The overall decrease in labile Ag for all soils after the 6 month ageing period was 50-100%. The ageing was more rapid and pronounced in the alkaline soils. XANES results for Ag in soils indicated that for the majority of soils the added Ag+ was reduced to metallic Ag over time, and associations with Fe-oxohydroxides and reduced S groups in organic matter also decreased Ag lability. Strong positive correlations were found between metallic Ag and non-labile Ag and between organic carbon and Ag bonded with S species. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Settimio, Lara; McLaughlin, Mike J.] Univ Adelaide, Sch Agr Food & Wine, Waite Res Inst, Glen Osmond, SA 5064, Australia. [McLaughlin, Mike J.; Kirby, Jason K.; Langdon, Kate A.] CSIRO Land & Water, Contaminant Chem & Ecotoxicol Program, Minerals Flagship, Glen Osmond, SA 5064, Australia. [Lombi, Enzo; Donner, Erica] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Settimio, L (reprint author), Univ Adelaide, Sch Agr Food & Wine, Waite Res Inst, Waite Rd, Glen Osmond, SA 5064, Australia. EM Lara.Settimio@adelaide.edu.au RI McLaughlin, Mike/F-2931-2010; Kirby, Jason/F-5942-2013; Donner, Erica/A-4809-2012; Lombi, Enzo/F-3860-2013 OI McLaughlin, Mike/0000-0001-6796-4144; Scheckel, Kirk/0000-0001-9326-9241; Donner, Erica/0000-0001-6465-2233; Lombi, Enzo/0000-0003-3384-0375 FU Precious Metals and Rhenium Consortium; Minerals Down Under Flagship (CSIRO); Australian Research Council [FT100100337, FT130101003, DP120101115] FX The authors thank the Precious Metals and Rhenium Consortium and Minerals Down Under Flagship (CSIRO) for financial support and acknowledge support from the Australian Research Council (FT100100337, FT130101003 and DP120101115). We also thank Cathy Fiebiger, Gill Cozens and Claire Wright for expert technical assistance. NR 56 TC 15 Z9 16 U1 6 U2 46 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD AUG PY 2014 VL 191 BP 151 EP 157 DI 10.1016/j.envpol.2014.04.030 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK7JS UT WOS:000338605200020 PM 24836503 ER PT J AU Oakes, M Baxter, L Long, TC AF Oakes, Michelle Baxter, Lisa Long, Thomas C. TI Evaluating the application of multipollutant exposure metrics in air pollution health studies SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Multipollutant; Air pollution; Exposure; Health effects ID FINE PARTICULATE MATTER; PM SOURCE APPORTIONMENT; DAILY MORTALITY; UNITED-STATES; TIME-SERIES; RISK-ASSESSMENT; INTAKE FRACTION; QUALITY INDEX; SPATIAL VARIABILITY; HOSPITAL ADMISSIONS AB Background: Health effects associated with air pollution are typically evaluated using a single pollutant approach, yet people are exposed to mixtures consisting of multiple pollutants that may have independent or combined effects on human health. Development of exposure metrics that represent the multipollutant environment is important to understand the impact of ambient air pollution on human health. Objectives: We reviewed existing multipollutant exposure metrics to evaluate how they can be applied to understand associations between air pollution and health effects. Methods: We conducted a literature search using both targeted search terms and a relational search in Web of Science and PubMed in April and December 2013. We focused on exposure metrics that are constructed from ambient pollutant concentrations and can be broadly applied to evaluate air pollution health effects. Results: Multipollutant exposure metrics were identified in 57 eligible studies. Metrics reviewed can be categorized into broad pollutant grouping paradigms based on: 1) source emissions and atmospheric processes or 2) common health outcomes. Discussion: When comparing metrics, it is apparent that no universal exposure metric exists; each type of metric addresses different research questions and provides unique information on human health effects. Key limitations of these metrics include the balance between complexity and simplicity as well as the lack of an existing "gold standard" for multipollutant health effects and exposure. Conclusions: Future work on characterizing multipollutant exposure error and joint effects will inform development of improved multipollutant metrics to advance air pollution health effects research and human health risk assessment. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Oakes, Michelle] Oak Ridge Inst Sci & Educ, Oak Ridge Natl Labs, Oak Ridge, TN USA. [Oakes, Michelle; Long, Thomas C.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Baxter, Lisa] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Oakes, M (reprint author), US EPA, 109 TW Alexander Dr,Mail Drop B-243-01, Res Triangle Pk, NC 27711 USA. FU U.S. Environmental Protection Agency Office of Research and Development FX The authors wish to give special thanks to Mr. Ryan Jones and Ms. Danielle Moore of the National Center for Environmental Assessment for their assistance in designing and conducting the literature review. The authors also wish to thank Dr. Steven J. Dutton, Dr. Thomas Luben, and Dr. Kathie L Dionisio for their helpful comments in review of this manuscript. MMO was supported by an appointment to the Research Participation Program of the U.S. Environmental Protection Agency Office of Research and Development administered by the Oak Ridge Institute for Science and Education (ORISE). NR 74 TC 17 Z9 19 U1 9 U2 57 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD AUG PY 2014 VL 69 BP 90 EP 99 DI 10.1016/j.envint.2014.03.030 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK7GM UT WOS:000338596600009 PM 24815342 ER PT J AU Ahir, BK Pratten, MK AF Ahir, Bhavesh K. Pratten, Margaret K. TI Developmental cardiotoxicity effects of four commonly used antiepileptic drugs in embryonic chick heart micromass culture and embryonic stem cell culture systems SO TOXICOLOGY IN VITRO LA English DT Article DE Antiepileptic drugs (AEDs); Chick heart micromass (MM) culture; D3 Mouse embryonic stem cell (ESC) culture; Congenital heart defects; Cardiotoxicity ID IN-VITRO; VALPROIC ACID; TERATOGENIC MECHANISM; PRENATAL EXPOSURE; KENACID-BLUE; PHENYTOIN; TOXICITY; TRIMETHADIONE; INVITRO; EMBRYOTOXICITY AB Antiepileptic drugs (AEDs) are commonly used drugs in pregnant women with epilepsy. Prenatal exposure to AEDs increases the risk of major or minor congenital malformation during embryonic development. The precise mode of action and intracellular mechanisms of these AEDs during embryonic development remains unclear. To determine relative teratogenic risk of AEDs, four AED drugs including valproic acid (VPA), phenytoin (PHT), phenobarbital (PB), and trimethadione (TMD) were tested using two in vitro systems (the embryonic chick heart micromass (MM) culture and the in vitro differentiating mouse embryonic stem cells into cardiomyocytes culture systems). Cardiomyocyte cultures (the heart MM and ES cell-derived cardiomyocytes) were treated with or without different concentrations of PHT, PB, TIVID (10-100 mu M), and VPA (100-2000 mu M). 5-Fluorouracil (5-FU) (1-10 mu M) and L.-ascorbic acid (10-1000 mu M) were used as positive and negative controls. It was found that these four commonly used AEDs and 5-FU tested have the potential to inhibit embryonic heart cell differentiation (p < 0.05) without inducing any cytotoxicity. VPA at higher concentrations ( >= 800 mu M), and 5-FU at all doses proved to be cytotoxic in the differentiating ES cell culture system. The results demonstrated in this study suggest that the use of these four commonly prescribed AEDs during pregnancy may have an effect on embryonic heart development, and may be associated with congenital cardiovascular defects. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Ahir, Bhavesh K.] US EPA, Natl Ctr Computat Toxicol B205 01, Res Triangle Pk, NC 27711 USA. [Pratten, Margaret K.] Univ Nottingham, Sch Life Sci, Queens Med Ctr, Nottingham NG7 2UH, England. RP Pratten, MK (reprint author), Univ Nottingham, Sch Life Sci, Queens Med Ctr, Nottingham NG7 2UH, England. EM margaret.pratten@nottingham.ac.uk FU Developing Research Scholarship, the International Office, of the University of Nottingham UK FX This work was funded by Developing Research Scholarship, the International Office, of the University of Nottingham UK. NR 76 TC 3 Z9 3 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD AUG PY 2014 VL 28 IS 5 BP 948 EP 960 DI 10.1016/j.tiv.2014.04.001 PG 13 WC Toxicology SC Toxicology GA AK7OE UT WOS:000338616800027 PM 24768975 ER PT J AU Dodder, RS AF Dodder, Rebecca S. TI A review of water use in the US electric power sector: insights from systems-level perspectives SO CURRENT OPINION IN CHEMICAL ENGINEERING LA English DT Review ID LIFE-CYCLE ASSESSMENT; POTENTIAL IMPACTS; ENERGY-PRODUCTION; GENERATION; NEXUS; SUSTAINABILITY; SEQUESTRATION; RESOURCES; SCENARIOS; CAPTURE AB Thermoelectric power production comprised 41% of total freshwater withdrawals in the U.S., surpassing even agriculture. This review highlights scenarios of the electric sector's future demands for water, including scenarios that limit both CO2 and water availability. A number of studies show withdrawals decreasing with retirement of existing electricity generating units. Consumption, the evaporative losses, also decreases in many scenarios. However, climate mitigation scenarios relying heavily on nuclear and carbon capture technologies may induce increases in water consumption. These increases in consumption represent a potential tradeoff between climate mitigation and adaptation of the electric sector to climate-related changes in water resources. It also points to the need for both analyses and technological solutions from the chemical engineering community. C1 US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Dodder, RS (reprint author), US EPA, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM dodder.rebecca@epa.gov NR 58 TC 9 Z9 9 U1 4 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2211-3398 J9 CURR OPIN CHEM ENG JI Curr. Opin. Chem. Eng. PD AUG PY 2014 VL 5 BP 7 EP 14 DI 10.1016/j.coche.2014.03.004 PG 8 WC Biotechnology & Applied Microbiology; Engineering, Chemical SC Biotechnology & Applied Microbiology; Engineering GA CM4QR UT WOS:000357670200004 ER PT J AU Yang, YJ Goodrich, JA AF Yang, Y. Jeffrey Goodrich, James A. TI Toward quantitative analysis of water-energy-urban-climate nexus for urban adaptation planning SO CURRENT OPINION IN CHEMICAL ENGINEERING LA English DT Article ID GREENHOUSE-GAS EMISSIONS; WASTE-WATER; DISTRIBUTION-SYSTEMS; CARBON FOOTPRINT; PERFORMANCE; RESOURCES; SCENARIOS; SCALE; INFRASTRUCTURE; OPTIMIZATION AB Water and energy are two interwoven factors affecting environmental management and urban development planning. Meanwhile, rapid urban development and a changing climate exacerbate the magnitude and effects of water-energy interactions in what a nexus defines. These factors and their mutual interactions affect how we evaluate urban developmental alternatives. In this perspective, a few pressing issues and a systems approach are discussed for quantitative analysis of the water-energy-climate-urban nexus in climate change mitigation and adaptation. C1 [Yang, Y. Jeffrey; Goodrich, James A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Goodrich, JA (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM Goodrich.James@epa.gov NR 83 TC 3 Z9 3 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2211-3398 J9 CURR OPIN CHEM ENG JI Curr. Opin. Chem. Eng. PD AUG PY 2014 VL 5 BP 22 EP 28 DI 10.1016/j.coche.2014.03.006 PG 7 WC Biotechnology & Applied Microbiology; Engineering, Chemical SC Biotechnology & Applied Microbiology; Engineering GA CM4QR UT WOS:000357670200006 ER PT J AU Sikdar, SK Agrawal, R AF Sikdar, Subhas K. Agrawal, Rakesh TI Editorial overview: Energy and environmental engineering: Energy-water nexus: transition from generic to specific SO CURRENT OPINION IN CHEMICAL ENGINEERING LA English DT Editorial Material C1 [Sikdar, Subhas K.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Agrawal, Rakesh] Purdue Univ, Sch Chem Engn, W Lafayette, IN 47907 USA. RP Sikdar, SK (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM sikdar.subhas@epa.gov; agrawalr@purdue.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2211-3398 J9 CURR OPIN CHEM ENG JI Curr. Opin. Chem. Eng. PD AUG PY 2014 VL 5 DI 10.1016/j.coche.2014.07.005 PG 2 WC Biotechnology & Applied Microbiology; Engineering, Chemical SC Biotechnology & Applied Microbiology; Engineering GA CM4QR UT WOS:000357670200001 ER PT J AU Cameron, C Yelverton, W Dodder, R West, JJ AF Cameron, Colin Yelverton, William Dodder, Rebecca West, J. Jason TI Strategic responses to CO2 emission reduction targets drive shift in U.S. electric sector water use SO ENERGY STRATEGY REVIEWS LA English DT Article DE Water-energy; Climate change; Energy modeling AB The U.S. electric sector's reliance on water makes it vulnerable to climate variability and change. Here we investigate whether carbon mitigation policies would improve or exacerbate electric sector water reliance. We use EPAUS9r MARKAL to model changes in U.S. electric sector water withdrawal and consumption through 2055 resulting from energy system-wide CO2 emissions reduction targets of 10%, 25%, and 50%, as well as nine sensitivity analysis scenarios. CO2 reduction strategies accelerate the deployment of more water-efficient thermoelectric generation technologies and increase the use of renewables, nuclear, and carbon capture. The 50% CO2 reduction scenario also prompts electrification in end-use demand sectors, most notably transportation, increasing electricity demand 36% by 2055. In aggregate, CO2 reduction strategies decrease national electric sector water withdrawal in all scenarios (-31% to -46% by 2055), but have a varied impact on water consumption (-4% to +42% by 2055). These changes in electricity generation technology and the resulting change in water use would likely reduce electric sector vulnerability to droughts and heat waves. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Cameron, Colin; West, J. Jason] Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Yelverton, William; Dodder, Rebecca] US EPA, Off Res & Dev, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. RP Cameron, C (reprint author), Int Inst Appl Syst Anal, Energy Program, Schlosspl 1, A-2361 Laxenburg, Austria. EM cameron@iiasa.ac.at RI West, Jason/J-2322-2015 OI West, Jason/0000-0001-5652-4987 FU U.S. Environmental Protection Agency, through its Office of Research and Development (ORD); ORD's National Risk Management Research Laboratory FX The U.S. Environmental Protection Agency, through its Office of Research and Development (ORD), funded the research described herein via a Student Services Contract with ORD's National Risk Management Research Laboratory. It has not been subjected to EPA review and therefore does not necessarily reflect the views of EPA, and no official endorsement should be inferred. NR 37 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2211-467X EI 2211-4688 J9 ENERGY STRATEG REV JI Energy Strateg. Rev. PD AUG PY 2014 VL 4 BP 16 EP 27 DI 10.1016/j.esr.2014.07.003 PG 12 WC Energy & Fuels SC Energy & Fuels GA V45RJ UT WOS:000209833400003 ER PT J AU Gabriel, M Knightes, C Cooter, E Dennis, R AF Gabriel, Mark Knightes, Christopher Cooter, Ellen Dennis, Robin TI The Impacts of Different Meteorology Data Sets on Nitrogen Fate and Transport in the SWAT Watershed Model SO ENVIRONMENTAL MODELING & ASSESSMENT LA English DT Article DE SWAT model; Nitrogen transport; MM5/WRF; Precipitation; Watershed; NCDC ID PRECIPITATION DATA; PARAMETER UNCERTAINTY; ASSESSMENT-TOOL; RAINFALL; SIMULATIONS; STREAMFLOW; RADAR; HYDROLOGY; KNOWLEDGE; ACCURACY AB In this study, we investigated how different meteorology data sets impacts nitrogen fate and transport responses in the Soil and Water Assessment Tool (SWAT) model. We used two meteorology data sets: National Climatic Data Center (observed) and Mesoscale Model 5/Weather Research and Forecasting (simulated). The SWAT model was applied to two 10-digit hydrologic unit code watersheds in the Coastal Plain and Piedmont zones of North Carolina. Nitrogen cycling and loading response to these meteorological data were investigated by exploring 19 SWAT nitrogen outputs relating to landscape delivery, biogeochemical assimilation, and atmospheric deposition. The largest difference in model output using both meteorology data sets was for large loads/fluxes. Landscape delivery outputs (e.g., NO- (3) watershed discharge, groundwater NO- (3) flux, soil NO- (3) percolation) showed the largest difference across all values. Use of the two weather data sources resulted in a nearly twofold difference in NO- (3) watershed discharge and groundwater NO- (3) flux. Differences for many nitrogen outputs were greater than those for sub-basin flow. Nitrogen outputs showed the greatest difference for agricultural land covers and there was no flow-related pattern in output differences across sub-basins or over time (years). In general, nitrogen parameter models that had a greater number of nitrate concentration, flow, and temperature terms (equation variables) in each transport model showed the greatest difference between both meteorology applications. C1 [Gabriel, Mark; Knightes, Christopher] US EPA, ORD, NERL, ERD, Athens, GA 30605 USA. [Cooter, Ellen; Dennis, Robin] US EPA, ORD, NERL, AMAD, Res Triangle Pk, NC 27711 USA. RP Gabriel, M (reprint author), US EPA, ORD, NERL, ERD, 960 Coll Stn Rd, Athens, GA 30605 USA. EM marklive02@yahoo.com NR 34 TC 3 Z9 3 U1 5 U2 26 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1420-2026 EI 1573-2967 J9 ENVIRON MODEL ASSESS JI Environ. Model. Assess. PD AUG PY 2014 VL 19 IS 4 BP 301 EP 314 DI 10.1007/s10666-014-9400-z PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK6DF UT WOS:000338517600004 ER PT J AU Jimenez-Valencia, J Kaufmann, PR Sattamini, A Mugnai, R Baptista, DF AF Jimenez-Valencia, Juliana Kaufmann, Philip R. Sattamini, Ana Mugnai, Riccardo Baptista, Darcilio Fernandes TI Assessing the ecological condition of streams in a southeastern Brazilian basin using a probabilistic monitoring design SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Ecological assessment; Streams; Probabilistic monitoring design; Multimetric index; Relative risk ID RIO-DE-JANEIRO; UNITED-STATES; BENTHIC MACROINVERTEBRATES; RAPID BIOASSESSMENT; MULTIMETRIC INDEX; WADEABLE STREAMS; NATIONAL ASSESSMENT; NATURAL-RESOURCES; AQUATIC RESOURCES; LAKES AB Prompt assessment and management actions are required if we are to reduce the current rapid loss of habitat and biodiversity worldwide. Statistically valid quantification of the biota and habitat condition in water bodies are prerequisites for rigorous assessment of aquatic biodiversity and habitat. We assessed the ecological condition of streams in a southeastern Brazilian basin. We quantified the percentage of stream length in good, fair, and poor ecological condition according to benthic macroinvertebrate assemblage. We assessed the risk of finding degraded ecological condition associated with degraded aquatic riparian physical habitat condition, watershed condition, and water quality. We describe field sampling and implementation issues encountered in our survey and discuss design options to remedy them. Survey sample sites were selected using a spatially balanced, stratified random design, which enabled us to put confidence bounds on the ecological condition estimates derived from the stream survey. The benthic condition index indicated that 62 % of stream length in the basin was in poor ecological condition, and 13 % of stream length was in fair condition. The risk of finding degraded biological condition when the riparian vegetation and forests in upstream catchments were degraded was 2.5 and 4 times higher, compared to streams rated as good for the same stressors. We demonstrated that the GRTS statistical sampling method can be used routinely in Brazilian rain forests and other South American regions with similar conditions. This survey establishes an initial baseline for monitoring the condition and trends of streams in the region. C1 [Jimenez-Valencia, Juliana; Baptista, Darcilio Fernandes] Univ Fed Rio de Janeiro, Inst Biol, Ilha Fundao, Programa Posgrad Ecol, BR-21941590 Rio de Janeiro, Brazil. [Jimenez-Valencia, Juliana; Sattamini, Ana; Mugnai, Riccardo; Baptista, Darcilio Fernandes] Fiocruz MS, IOC, Lab Avaliacao & Promocao Saude Ambiental, BR-21040360 Rio De Janeiro, Brazil. [Kaufmann, Philip R.] US EPA, Corvallis, OR 97333 USA. RP Jimenez-Valencia, J (reprint author), Univ Fed Rio de Janeiro, Inst Biol, Ilha Fundao, Programa Posgrad Ecol, BR-21941590 Rio de Janeiro, Brazil. EM jjvingamb@gmail.com RI Baptista, Darcilio/C-7499-2013 FU Brazilian National Council for Scientific and Technological Development [CNPq/PROEP 400107/2011-2] FX This work was sponsored by the Brazilian National Council for Scientific and Technological Development (Grant CNPq/PROEP 400107/2011-2). We are grateful to all LAPSA team members for field assistance, GIS data, and their contributions with the accomplishment of this study. We thank Beau Carrillo for support with writing, Bob Hughes and Tony Olsen for their valuable comments and help with sampling design, and two anonymous reviewers for their contributions to the final manuscript. NR 51 TC 2 Z9 2 U1 3 U2 35 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD AUG PY 2014 VL 186 IS 8 BP 4685 EP 4695 DI 10.1007/s10661-014-3730-9 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK2UR UT WOS:000338275500004 PM 24829159 ER PT J AU Cantwell, MG Perron, MM Sullivan, JC Katz, DR Burgess, RM King, J AF Cantwell, Mark G. Perron, Monique M. Sullivan, Julia C. Katz, David R. Burgess, Robert M. King, John TI Assessing organic contaminant fluxes from contaminated sediments following dam removal in an urbanized river SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Dam removal; Sediment resuspension; Contaminant release; Contaminant fluxes; Sediment trap; Passive samplers AB In this study, methods and approaches were developed and tested to assess changes in contaminant fluxes resulting from dam removal in a riverine system. Sediment traps and passive samplers were deployed to measure particulate and dissolved polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in the water column prior to and following removal of a small, low-head dam in the Pawtuxet River, an urbanized river located in Cranston, RI, USA. During the study, concentrations of particulate and dissolved PAHs ranged from 21.5 to 103 mu g/g and from 68 to 164 ng/L, respectively. Overall, temporal trends of PAHs showed no increases in either dissolved or particulate phases following removal of the dam. Dissolved concentrations of PCBs were very low, remaining below 1.72 ng/L at all sites. Particulate PCB concentrations across sites and time showed slightly greater variability, ranging from 80 to 469 ng/g, but with no indication that dam removal influenced any increases. Particulate PAHs and PCBs were sampled continuously at the site located below the dam and did not show sustained increases in concentration resulting from dam removal. The employment of passive sampling technology and sediment traps was highly effective in monitoring the concentrations and flux of contaminants moving through the river system. Variations in river flow had no effect on the concentration of contaminants in the dissolved or particulate phases, but did influence the flux rate of contaminants exiting the river. Overall, dam removal did not cause measurable sediment disturbance or increase the concentration or fluxes of dissolved or particulate PAHs and PCBs. This is due in large part to low volumes of impounded sediment residing above the dam and highly armored sediments in the river channel, which limited erosion. Results from this study will be used to improve methods and approaches that assess the short- and long-term impacts ecological restoration activities such as dam removal have on the release and transport of sediment-bound contaminants. C1 [Cantwell, Mark G.; Katz, David R.; Burgess, Robert M.] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Perron, Monique M.] US EPA, Off Pesticide Program, Washington, DC 20460 USA. [Sullivan, Julia C.] Oak Ridge Inst Sci & Educ, Narragansett, RI 02882 USA. [King, John] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. RP Cantwell, MG (reprint author), US EPA, Off Res & Dev, Narragansett, RI 02882 USA. EM cantwell.mark@epa.gov FU U.S. Department of Energy; EPA; National Institute of Health via Brown University; National Research Council via U.S. EPA; U.S. Environmental Protection Agency FX The authors thank Drs. Diane Nacci, Peg Pelletier, and Mr. Steven Rego for their technical reviews. This research was supported in part by an appointment to the Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. Dr. M.M. Perron was financially supported by postdoctoral positions with the National Institute of Health and the National Research Council funded via Brown University and U.S. EPA, respectively. Although research described in this article has been wholly funded by the U.S. Environmental Protection Agency and has been technically reviewed at the Atlantic Ecology Division, it has not been subjected to Agency-level review. Therefore, it does not necessarily reflect the views of the Agency. This manuscript is contribution number ORD-005438 of the Atlantic Ecology Division of the United States Environmental Protection Agency, Office of Research and Development, National Health Effects Environmental Research Laboratory. Mention of trade names does not constitute endorsement or recommendation for use. NR 30 TC 7 Z9 7 U1 3 U2 52 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD AUG PY 2014 VL 186 IS 8 BP 4841 EP 4855 DI 10.1007/s10661-014-3742-5 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK2UR UT WOS:000338275500016 PM 24729181 ER PT J AU Subedi, B Yun, S Jayaraman, S Bergen, BJ Kannan, K AF Subedi, Bikram Yun, Sehun Jayaraman, Saro Bergen, Barbara J. Kannan, Kurunthachalam TI Retrospective monitoring of persistent organic pollutants, including PCBs, PBDEs, and polycyclic musks in blue mussels (Mytilus edulis) and sediments from New Bedford Harbor, Massachusetts, USA: 1991-2005 SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE New Bedford Harbor; Mussel; Polycyclic musks; PAHs; PBDEs; PCBs; Pesticides; Sediment ID CONTAMINATED WASTE SITE; WATER TREATMENT PLANTS; MARINE SUPERFUND SITE; POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE PESTICIDES; AROMATIC-HYDROCARBONS; SYNTHETIC MUSKS; TROPHIC LEVEL; NEW-YORK; BIOACCUMULATION AB Blue mussels (Mytilus edulis) and sediments collected from 1991 to 2005 from New Bedford Harbor (NBH), MA, were analyzed for two polycyclic musks (HHCB or GalaxolideA (R) and AHTN or TonalideA (R)), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs). HHCB and AHTN were found in mussel tissues at mean concentrations of 836 and 376 ng/g lipid weight (lw), respectively, which were two- to seven-fold higher than those found at a reference site. Mean concentrations of HHCB and AHTN in NBH sediments were 12 and 6.3 ng/g dry weight (dw), respectively. Four- and five-ringed PAHs, such as phenanthrene, anthracene, fluoranthene, and pyrene, collectively accounted for 61 % of the aPAHs concentrations in mussels from NBH. Mean I PCB pound concentrations in mussels from upper and lower NBH were 942 and 182 mu g/g lw, respectively, and were dominated by tetra- and penta-chlorobiphenyl congeners, collectively accounting for 61 % of the I PCB pound concentrations. The mean concentration of aPBDEs in mussels from NBH was 277 ng/g lw, and no significant difference existed in the concentrations between upper and lower NBH. DDTs were the major OCP found in mussels, found at a mean concentration of 778 ng/g lw. The concentrations of HHCB, AHTN, I PBDEs pound, I PAHs pound, and DDTs in mussels decreased significantly (r (2) a parts per thousand yenaEuro parts per thousand 0.56, p a parts per thousand currency signaEuro parts per thousand 0.052) from 1991 to 2005. The concentrations of PCBs and chlordanes did not exhibit a decreasing trend in mussel tissues (r (2) < 0.50; p > 0.076) from 1991 to 2005. Based on the temporal trends in the concentrations of HHCB, AHTN, aPAHs, and aPBDEs found in mussels from NBH, it was estimated that between 5.5 and 12 years were required for the concentrations of these compounds to decrease by half (i.e., environmental halving time) of the levels found in 1991. C1 [Subedi, Bikram; Yun, Sehun; Kannan, Kurunthachalam] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA. [Subedi, Bikram; Yun, Sehun; Kannan, Kurunthachalam] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Albany, NY 12201 USA. [Jayaraman, Saro; Bergen, Barbara J.] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Narragansett, RI USA. RP Kannan, K (reprint author), New York State Dept Hlth, Wadsworth Ctr, Empire State Plaza,POB 509, Albany, NY 12201 USA. EM kkannan@wadsworth.org NR 41 TC 7 Z9 7 U1 3 U2 48 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD AUG PY 2014 VL 186 IS 8 BP 5273 EP 5284 DI 10.1007/s10661-014-3776-8 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA AK2UR UT WOS:000338275500049 PM 24781305 ER PT J AU Yau, VM Schiff, KC Arnold, BF Griffith, JF Gruber, JS Wright, CC Wade, TJ Burns, S Hayes, JM McGee, C Gold, M Cao, YP Boehm, AB Weisberg, SB Colford, JM AF Yau, Vincent M. Schiff, Kenneth C. Arnold, Benjamin F. Griffith, John F. Gruber, Joshua S. Wright, Catherine C. Wade, Timothy J. Burns, Susan Hayes, Jacqueline M. McGee, Charles Gold, Mark Cao, Yiping Boehm, Alexandria B. Weisberg, Stephen B. Colford, John M., Jr. TI Effect of submarine groundwater discharge on bacterial indicators and swimmer health at Avalon Beach, CA, USA SO WATER RESEARCH LA English DT Article DE Indicator organisms; Water quality; Marine water; qPCR; Gastrointestinal illness ID RECREATIONAL WATER-QUALITY; RAPIDLY MEASURED INDICATORS; ESCHERICHIA-COLI; FECAL POLLUTION; SURF ZONE; GASTROINTESTINAL ILLNESS; MEASUREMENT ERROR; MARINE WATER; FRESH-WATER; SEAWATER AB Use of fecal indicator bacteria (FIB) for monitoring beach water quality is based on their co-occurrence with human pathogens, a relationship that can be dramatically altered by fate and transport processes after leaving the human intestine. We conducted a prospective cohort study at Avalon Beach, California (USA), where the indicator relationship is potentially affected by the discharge of sewage-contaminated groundwater and by solar radiation levels at this shallow, relatively quiescent beach. The goals of this study were to determine: 1) if swimmers exposed to marine water were at higher risk of illness than nonswimmers; 2) if FIB measured in marine water were associated with swimmer illness, and; 3) if the associations between FIB and swimmer health were modified by either submarine groundwater discharge or solar radiation levels. There were 7317 individuals recruited during the summers of 2007-08, 6165 (84%) of whom completed follow-up within two weeks of the beach visit. A total of 703 water quality samples were collected across multiple sites and time periods during recruitment days and analyzed for FIB using both culture-based and molecular methods. Adjusted odds ratios (AOR) indicated that swimmers who swallowed water were more likely to experience Gastrointestinal Illness (GI Illness) within three days of their beach visit than non-swimmers, and that this risk was significantly elevated when either submarine groundwater discharge was high (AOR [95% CI]:2.18 [1.22-3.89]) or solar radiation was low (2.45 [1.25-4.79]). The risk of GI Illness was not significantly elevated for swimmers who swallowed water when groundwater discharge was low or solar radiation was high. Associations between GI Illness incidence and FIB levels (Enterococcus EPA Method 1600) among swimmers who swallowed water were not significant when we did not account for groundwater discharge, but were strongly associated when groundwater discharge was high (1.85 [1.06, 3.23]) compared to when it was low (0.77 [0.42, 1.42]; test of interaction: P = 0.03). These results demonstrate the need to account for local environmental conditions when monitoring for, and making decisions about, public health at recreational beaches. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Yau, Vincent M.; Arnold, Benjamin F.; Gruber, Joshua S.; Wright, Catherine C.; Colford, John M., Jr.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Yau, Vincent M.] Kaiser Permanente, Div Res, Oakland, CA USA. [Schiff, Kenneth C.; Griffith, John F.; Cao, Yiping; Weisberg, Stephen B.] Southern Calif Coastal Water Res Project, Costa Mesa, CA USA. [Wade, Timothy J.] US EPA, Natl Environm Hlth Effects Res Lab, Chapel Hill, NC USA. [Burns, Susan; Hayes, Jacqueline M.] Univ Calif Berkeley, Survey Res Ctr, Berkeley, CA 94720 USA. [McGee, Charles] Orange Cty Sanitat Dist, Fountain Valley, CA USA. [Gold, Mark] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA USA. [Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. RP Colford, JM (reprint author), Univ Calif Berkeley, Sch Publ Hlth, 113A Haviland Hall,MC 7358, Berkeley, CA 94720 USA. EM jcolford@berkeley.edu RI Weisberg, Stephen/B-2477-2008 OI Weisberg, Stephen/0000-0002-0655-9425 FU California State Water Resources Control Board [06-073-559-0]; U.S. Environmental Protection Agency [X7-99997801-0] FX We would like to acknowledge the following individuals for their invaluable insight and assistance with this study: Donna Ferguson, Melissa Madison, and Darcy Ebentier. We thank Jed Fuhrman, John Witte, Hildy Meyers, and David Kay for their technical expertise and input, and Rachel Noble and Richard Haugland for comments on preliminary results and findings. This study was partially funded by the California State Water Resources Control Board (Grant #06-073-559-0) and the U.S. Environmental Protection Agency (Grant #X7-99997801-0). NR 58 TC 9 Z9 9 U1 7 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD AUG 1 PY 2014 VL 59 BP 23 EP 36 DI 10.1016/j.watres.2014.03.050 PG 14 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AJ7FA UT WOS:000337861400003 PM 24776951 ER PT J AU Yang, F Shi, BY Bai, YH Sun, HF Lytle, DA Wang, DS AF Yang, Fan Shi, Baoyou Bai, Yaohui Sun, Huifang Lytle, Darren A. Wang, Dongsheng TI Effect of sulfate on the transformation of corrosion scale composition and bacterial community in cast iron water distribution pipes SO WATER RESEARCH LA English DT Article DE Drinking water distribution system (DWDS); Corrosion scale; Iron release; Bacterial community; Sulfate ID DISTRIBUTION-SYSTEM; PHYSICOCHEMICAL CHARACTERISTICS; BIOFILM; STEEL; RELEASE AB The chemical stability of iron corrosion scales and the microbial community of biofilm in drinking water distribution system (DWDS) can have great impact on the iron corrosion and corrosion product release, which may result in "red water" issues, particularly under the situation of source water switch. In this work, experimental pipe loops were set up to investigate the effect of sulfate on the dynamical transformation characteristics of iron corrosion products and bacterial community in old cast iron distribution pipes. All the test pipes were excavated from existing DWDS with different source water supply histories, and the test water sulfate concentration was in the range of 50-350 mg/L. Pyrosequencing of 16S rRNA was used for bacterial community analysis. The results showed that iron release increased markedly and even "red water" occurred for pipes with groundwater supply history when feed water sulfate elevated abruptly. However, the iron release of pipes with only surface water supply history changed slightly without noticeable color even the feed water sulfate increased multiply. The thick-layered corrosion scales (or densely distributed tubercles) on pipes with surface water supply history possessed much higher stability due to the larger proportion of stable constituents (mainly Fe3O4) in their top shell layer; instead, the rather thin and uniform non-layered corrosion scales on pipes with groundwater supply history contained relatively higher proportion of less stable iron oxides (e.g. beta-FeOOH, FeCO3 and green rust). The less stable corrosion scales tended to be more stable with sulfate increase, which was evidenced by the gradually decreased iron release and the increased stable iron oxides. Bacterial community analysis indicated that when switching to high sulfate water, iron reducing bacteria (IRB) maintained dominant for pipes with stable corrosion scales, while significant increase of sulfur oxidizing bacteria (SOB), sulfate reducing bacteria (SRB) and iron oxidizing bacteria (IOB) was observed for pipes with less stable corrosion scales. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Yang, Fan; Shi, Baoyou; Bai, Yaohui; Sun, Huifang; Wang, Dongsheng] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China. [Yang, Fan] Tianjin Agr Univ, Coll Engn & Technol, Tianjin 300384, Peoples R China. [Lytle, Darren A.] US EPA, Cincinnati, OH 45268 USA. RP Shi, BY (reprint author), Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China. EM byshi@rcees.ac.cn FU National Natural Science Foundation of China [51178450, 51378493, 51308392]; National Water Pollution Control and Treatment Special Key Project of China [2012ZX07404-002, 2012ZX07408-002] FX This work was financially supported by National Natural Science Foundation of China (51178450, 51378493 and 51308392) and National Water Pollution Control and Treatment Special Key Project of China (2012ZX07404-002, 2012ZX07408-002). NR 28 TC 14 Z9 16 U1 4 U2 76 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD AUG 1 PY 2014 VL 59 BP 46 EP 57 DI 10.1016/j.watres.2014.04.003 PG 12 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AJ7FA UT WOS:000337861400005 PM 24784453 ER PT J AU Jathar, SH Gordon, TD Hennigan, CJ Pye, HOT Pouliot, G Adams, PJ Donahue, NM Robinson, AL AF Jathar, Shantanu H. Gordon, Timothy D. Hennigan, Christopher J. Pye, Havala O. T. Pouliot, George Adams, Peter J. Donahue, Neil M. Robinson, Allen L. TI Unspeciated organic emissions from combustion sources and their influence on the secondary organic aerosol budget in the United States SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE particulate matter; air quality; photochemical oxidation; volatile organic compounds; emissions inventory ID AIR-POLLUTION SOURCES; DUTY DIESEL TRUCKS; VEHICLE EMISSIONS; SMOG CHAMBER; IN-USE; GASOLINE; PARTICLE; IMPACT; MODEL; PHOTOOXIDATION AB Secondary organic aerosol (SOA) formed from the atmospheric oxidation of nonmethane organic gases (NMOG) is a major contributor to atmospheric aerosol mass. Emissions and smog chamber experiments were performed to investigate SOA formation from gasoline vehicles, diesel vehicles, and biomass burning. About 10-20% of NMOG emissions from these major combustion sources are not routinely speciated and therefore are currently misclassified in emission inventories and chemical transport models. The smog chamber data demonstrate that this misclassification biases model predictions of SOA production low because the unspeciated NMOG produce more SOA per unit mass than the speciated NMOG. We present new source-specific SOA yield parameterizations for these unspeciated emissions. These parameterizations and associated source profiles are designed for implementation in chemical transport models. Box model calculations using these new parameterizations predict that NMOG emissions from the top six combustion sources form 0.7 Tg y(-1) of first-generation SOA in the United States, almost 90% of which is from biomass burning and gasoline vehicles. About 85% of this SOA comes from unspeciated NMOG, demonstrating that chemical transport models need improved treatment of combustion emissions to accurately predict ambient SOA concentrations. C1 [Jathar, Shantanu H.; Gordon, Timothy D.; Hennigan, Christopher J.; Adams, Peter J.; Donahue, Neil M.; Robinson, Allen L.] Carnegie Mellon Univ, Ctr Atmospher Particle Studies, Pittsburgh, PA 15213 USA. [Pye, Havala O. T.; Pouliot, George] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Robinson, AL (reprint author), Carnegie Mellon Univ, Ctr Atmospher Particle Studies, Pittsburgh, PA 15213 USA. EM alr@andrew.cmu.edu RI Robinson, Allen/M-3046-2014; Donahue, Neil/A-2329-2008; Jathar, Shantanu/A-2966-2015; Gordon, Timothy/H-9497-2013; Hennigan, Christopher/A-9221-2013; Adams, Peter/D-7134-2013; Pye, Havala/F-5392-2012 OI Robinson, Allen/0000-0002-1819-083X; Donahue, Neil/0000-0003-3054-2364; Jathar, Shantanu/0000-0003-4106-2358; Gordon, Timothy/0000-0002-5128-9532; Hennigan, Christopher/0000-0002-2454-2838; Adams, Peter/0000-0003-0041-058X; Pye, Havala/0000-0002-2014-2140 FU US Environmental Protection Agency National Center for Environmental Research through the Science to Achieve Results program [RD834554]; Coordinating Research Council [A74/E96] FX This research was funded by the US Environmental Protection Agency National Center for Environmental Research through the Science to Achieve Results program (Project RD834554) and by the Coordinating Research Council through projects A74/E96. The US Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. This paper has been subjected to the Agency's administrative review and approved for publication. NR 45 TC 35 Z9 35 U1 19 U2 112 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 22 PY 2014 VL 111 IS 29 BP 10473 EP 10478 DI 10.1073/pnas.1323740111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AL7JS UT WOS:000339310700031 PM 25002466 ER PT J AU Liao, XY Zhao, D Yan, XL Huling, SG AF Liao, Xiaoyong Zhao, Dan Yan, Xiulan Huling, Scott G. TI Identification of persulfate oxidation products of polycyclic aromatic hydrocarbon during remediation of contaminated soil SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Persulfate; Chemical oxidation; Oxy-PAH; Soil remediation; Intermediates ID DIRECTED CHEMICAL-ANALYSIS; GENOTOXIC COMPONENTS; METABOLIC-ACTIVATION; PAHS; DEGRADATION; TOXICITY; OZONATION; ACENAPHTHYLENE; BIODEGRADATION; BIOREMEDIATION AB The extent of PAH transformation, the formation and transformation of reaction byproducts during persulfate oxidation of polycyclic aromatic hydrocarbons (PAHs) in coking plant soil was investigated. Pre-oxidation analyses indicated that oxygen-containing PAHs (oxy-PAHs) existed in the soil. Oxy-PAHs including 1H-phenalen-1-one, 9H-fluoren-9-one, and 1,8-naphthalic anhydride were also produced during persulfate oxidation of PAHs. Concentration of 1,8-naphthalic anhydride at 4h in thermally activated (50 degrees C) persulfate oxidation (TAPO) treatment increased 12.7 times relative to the oxidant-free control. Additionally, the oxy-PAHs originally present and those generated during oxidation can be oxidized by unactivated or thermally activated persulfate oxidation. For example, 9H-fluoren-9-one concentration decreased 99% at 4 h in TAPO treatment relative to the control. Thermally activated persulfate resulted in greater oxy-PAHs removal than unactivated persulfate. Overall, both unactivated and thermally activated persulfate oxidation of PAH-contaminated soil reduced PAH mass, and oxidized most of the reaction byproducts. Consequently, this treatment process could limit environmental risk related to the parent compound and associated reaction byproducts. (C) 2014 Elsevier B.V. All rights reserved. C1 [Liao, Xiaoyong; Zhao, Dan; Yan, Xiulan] Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China. [Huling, Scott G.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK USA. RP Liao, XY (reprint author), Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, 11A,Datun Rd, Beijing 100101, Peoples R China. EM Liaoxy@igsnrr.ac.cn FU National High Technology Research and Development Program of China (863 Program) [2012AA06A201]; Equipment Manufacturing Project of Chinese Academy of Science [YZ201105] FX This work was supported by the National High Technology Research and Development Program of China (863 Program, Grant No. 2012AA06A201) and the Equipment Manufacturing Project of Chinese Academy of Science (Grant No. YZ201105). NR 41 TC 11 Z9 14 U1 13 U2 94 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUL 15 PY 2014 VL 276 BP 26 EP 34 DI 10.1016/j.jhazmat.2014.05.018 PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AM2PG UT WOS:000339692700004 PM 24862467 ER PT J AU Alexis, NE Huang, YCT Rappold, AG Kehrl, H Devlin, R Peden, DB AF Alexis, Neil E. Huang, Yuh Chin T. Rappold, Ana G. Kehrl, Howard Devlin, Robert Peden, David B. TI Patients with Asthma Demonstrate Airway Inflammation after Exposure to Concentrated Ambient Particulate Matter SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Letter ID POLLUTION PARTICLES; DEPOSITION; FINE C1 [Alexis, Neil E.] Univ N Carolina, Sch Med, Chapel Hill, NC 27514 USA. [Huang, Yuh Chin T.] Duke Univ, Durham, NC USA. [Rappold, Ana G.; Kehrl, Howard; Devlin, Robert] US Environm Protect Agcy, Durham, NC USA. [Peden, David B.] Univ N Carolina, Sch Med, Durham, NC USA. RP Alexis, NE (reprint author), Univ N Carolina, Sch Med, Chapel Hill, Chapel Hill, NC 27514 USA. FU NIEHS NIH HHS [P30 ES010126, R01ES012706, R01 ES012706] NR 13 TC 4 Z9 4 U1 1 U2 7 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JUL 15 PY 2014 VL 190 IS 2 BP 235 EP 237 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AL9OT UT WOS:000339471300021 PM 25025358 ER PT J AU Blaine, AC Rich, CD Sedlacko, EM Hundal, LS Kumar, K Lau, C Mills, MA Harris, KM Higgins, CP AF Blaine, Andrea C. Rich, Courtney D. Sedlacko, Erin M. Hundal, Lakhwinder S. Kumar, Kuldip Lau, Christopher Mills, Marc A. Harris, Kimberly M. Higgins, Christopher P. TI Perfluoroalkyl Acid Distribution in Various Plant Compartments of Edible Crops Grown in Biosolids-Amended soils SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MAIZE ZEA-MAYS; PERFLUOROOCTANE SULFONATE; SUBSTANCES; TRANSPORT; XENOBIOTICS; ENVIRONMENT; GREENHOUSE; CHEMICALS; ROOTS; FIELD AB Crop uptake of perfluoroalkyl acids (PFAAs) from biosolids-amended soil has been identified as a potential pathway for PFAA entry into the terrestrial food chain. This study compared the uptake of PFAAs in greenhouse-grown radish (Raphanus sativus), celery (Apium graveolens var. dulce), tomato (Lycopersicon lycopersicum), and sugar snap pea (Pisum sativum var. macrocarpon) from an industrially impacted biosolids-amended soil, a municipal biosolids-amended soil, and a control soil. Individual concentrations of PFAAs, on a dry weight basis, in mature, edible portions of crops grown in soil amended with PFAA industrially impacted biosolids were highest for perfluorooctanoate (PFOA; 67 ng/g) in radish root, perfluorobutanoate (PFBA; 232 ng/g) in celery shoot, and PFBA (150 ng/g) in pea fruit. Comparatively, PFAA concentrations in edible compartments of crops grown in the municipal biosolids-amended soil and in the control soil were less than 25 ng/g. Bioaccumulation factors (BAFs) were calculated for the root, shoot, and fruit compartments (as applicable) of all crops grown in the industrially impacted soil. BAFs were highest for PFBA in the shoots of all crops, as well as in the fruit compartment of pea. Root-soil concentration factors (RCFs) for tomato and pea were independent of PFAA chain length, while radish and celery RCFs showed a slight decrease with increasing chain length. Shoot-soil concentration factors (SCFs) for all crops showed a decrease with increasing chain length (0.11 to 0.36 log decrease per CF2 group). The biggest decrease (0.54-0.58 log decrease per CF2 group) was seen in fruit-soil concentration factors (FCFs). Crop anatomy and PFAA properties were utilized to explain data trends. In general, fruit crops were found to accumulate fewer long-chain PFAAs than shoot or root crops presumably due to an increasing number of biological barriers as the contaminant is transported throughout the plant (roots to shoots to fruits). These data were incorporated into a preliminary conceptual framework for PFAA accumulation in edible crops. In addition, these data suggest that edible crops grown in soils conventionally amended for nutrients with biosolids (that are not impacted by PFAA industries) are unlikely a significant source of long-chain PFAA exposure to humans. C1 [Blaine, Andrea C.; Rich, Courtney D.; Sedlacko, Erin M.; Higgins, Christopher P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. [Hundal, Lakhwinder S.; Kumar, Kuldip] Metropolitan Water Reclamat Dist Greater Chicago, Chicago, IL 60611 USA. [Lau, Christopher] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Mills, Marc A.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Harris, Kimberly M.] US EPA, Chicago, IL 60604 USA. RP Higgins, CP (reprint author), Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. EM chiggins@mines.edu RI Higgins, Christopher/B-1836-2010; Mills, Marc/C-3449-2017 OI Higgins, Christopher/0000-0001-6220-8673; Mills, Marc/0000-0002-0169-3086 FU U.S. EPA; U.S. Environmental Protection Agency FX This research is funded by a RARE grant from the U.S. EPA, and is supported by efforts from the Metropolitan Water Reclamation District of Greater Chicago. We appreciate the help of various U.S. EPA staff; and in particular, Lee Thomas (Region 4), Carole Braverman, Bradley Grams, Gerald Golubski, Kenneth Gunter, Erin Newman, Thomas Poy, David Schroeder (Region 5), Mark Strynar, Rebecca McMahan and Shuang Liang (ORD). We would also like to acknowledge the help of Kate Percival and Karen Kazor from CSM and Cecil Stushnoff from Colorado State University. The information in this document has been funded by the U.S. Environmental Protection Agency. It has been subjected to review by the Region 5 Office and the Office of Research and Development (ORD) and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 25 TC 17 Z9 17 U1 15 U2 69 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2014 VL 48 IS 14 BP 7858 EP 7865 DI 10.1021/es500016s PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AL6FH UT WOS:000339227500024 PM 24918303 ER PT J AU Zimmerman, BD Ashbolt, NJ Garland, JL Keely, S Wendell, D AF Zimmerman, Brian D. Ashbolt, Nicholas J. Garland, Jay L. Keely, Scott Wendell, David TI Human Mitochondrial DNA and Endogenous Bacterial Surrogates for Risk Assessment of Graywater Reuse SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID REAL-TIME PCR; RESISTANT STAPHYLOCOCCUS-AUREUS; VIBRIO-PARAHAEMOLYTICUS; DOMESTIC GREYWATER; MICROBIAL QUALITY; ESCHERICHIA-COLI; FECAL POLLUTION; UNITED-STATES; WATER; PATHOGENS AB Previous graywater risk assessment studies have focused on fecal contamination, yet the low density of fecal indicators may not provide the most useful approach to assess pathogen removal during graywater treatment. In this study, we employed high throughput bacterial sequencing and qPCR to elucidate potential microbial surrogates in wastewater sourced from an industrial laundry. In addition, we explored human mitochondrial DNA (HmtDNA) as a new, potentially more reliable molecular marker, because it can be unambiguously sourced, has a high copy number per cell, and is persistent when released from cells with no self-replication in graywater. Pyrosequencing and qPCR revealed that laundry water microbiota was dominated by the skin-associated bacteria Staphylococcus, Corynebacterium, and Propionibacterium (6.5, 5.7, 5.4 log(10) copies/100 mL, respectively). While HmtDNA was less abundant (2.8 log(10) copies/100 mL), it showed a strong positive correlation with the opportunistic pathogen Staphylococcus aureus (r = 0.54, P = 3.2 x 10(-4)) and closely followed a first-order exponential decay model (R-2 = 0.98), remaining detectable in stored laundry graywater for up to 6 days at 20 degrees C. Based on abundance and persistence, we propose HmtDNA and total Staphylococcus as future laundry graywater treatment surrogates to potentially assess a wide dynamic range of pathogen removal. C1 [Zimmerman, Brian D.; Wendell, David] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. [Zimmerman, Brian D.; Ashbolt, Nicholas J.; Garland, Jay L.; Keely, Scott] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Wendell, D (reprint author), Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. EM wendeldw@uc.edu FU USEPA FX Funding for this research was provided by the USEPA. NR 72 TC 6 Z9 6 U1 3 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2014 VL 48 IS 14 BP 7993 EP 8002 DI 10.1021/es501659r PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AL6FH UT WOS:000339227500040 PM 24932937 ER PT J AU Fay, KA Mingoia, RT Goeritz, I Nabb, DL Hoffman, AD Ferrell, BD Peterson, HM Nichols, JW Segner, H Han, X AF Fay, Kellie A. Mingoia, Robert T. Goeritz, Ina Nabb, Diane L. Hoffman, Alex D. Ferrell, Barbra D. Peterson, Heather M. Nichols, John W. Segner, Helmut Han, Xing TI Intra- and Interlaboratory Reliability of a Cryopreserved Trout Hepatocyte Assay for the Prediction of Chemical Bioaccumulation Potential SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID XENOBIOTIC INTRINSIC CLEARANCE; FRESHLY ISOLATED HEPATOCYTES; ONCORHYNCHUS-MYKISS; ORGANIC-CHEMICALS; ENZYME-ACTIVITIES; FISH; BIOCONCENTRATION; RAT; BIOTRANSFORMATION; ASSESSMENTS AB Measured rates of intrinsic clearance determined using cryopresenred trout hepatocytes can be extrapolated to the whole animal as a means of improving modeled bioaccumulation predictions for fish. To date, however, the intra- and interlaboratory reliability of this procedure has not been determined. In the present study, three laboratories determined in vitro intrinsic clearance of six reference compounds (benzo[a]pyrene, 4-nonylphenol, di-tert-butyl phenol, fenthion, methoxychlor and o-terphenyl) by conducting substrate depletion experiments with cryopreserved trout hepatocytes from a single source. O-terphenyl was excluded from the final analysis due to nonfirst-order depletion kinetics and significant loss from denatured controls. For the other five compounds, intralaboratory variability (% CV) in measured in vitro intrinsic clearance values ranged from 4.1 to 30%, while interlaboratory variability ranged from 27 to 61%. Predicted bioconcentration factors based on in vitro clearance values exhibited a reduced level of interlaboratory variability (5.3-38% CV). The results of this study demonstrate that cryopreserved trout hepatocytes can be used to reliably obtain in vitro intrinsic clearance of xenobiotics, which provides support for the application of this in vitro method in a weight-of-evidence approach to chemical bioaccumulation assessment. C1 [Fay, Kellie A.; Hoffman, Alex D.; Nichols, John W.] US EPA, ORD, NHEERL, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Mingoia, Robert T.; Nabb, Diane L.; Ferrell, Barbra D.; Peterson, Heather M.; Han, Xing] DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19711 USA. [Goeritz, Ina; Segner, Helmut] Univ Bern, Ctr Fish & Wildlife Hlth, CH-3012 Bern, Switzerland. [Goeritz, Ina] Fraunhofer Inst Mol Biol & Appl Ecol, D-57392 Schmallenberg, Germany. RP Nichols, JW (reprint author), US EPA, ORD, NHEERL, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM nichols.john@epa.gov; xing.han@dupont.com FU Fraunhofer Institute for Molecular Biology and Applied Ecology; HESI (Health and Environmental Sciences Institute); Stiftung 3R FX The work at the University of Bern was substantially supported by the Fraunhofer Institute for Molecular Biology and Applied Ecology, with financial support from HESI (Health and Environmental Sciences Institute) and Stiftung 3R. The views expressed in this paper are those of the authors, and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 22 TC 8 Z9 9 U1 0 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2014 VL 48 IS 14 BP 8170 EP 8178 DI 10.1021/es500952a PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AL6FH UT WOS:000339227500061 PM 24941452 ER PT J AU Ellestad, LE Cardon, M Chambers, IG Farmer, JL Hartig, P Stevens, K Villeneuve, DL Wilson, V Orlando, EF AF Ellestad, Laura E. Cardon, Mary Chambers, Ian G. Farmer, Jennifer L. Hartig, Phillip Stevens, Kyle Villeneuve, Daniel L. Wilson, Vickie Orlando, Edward F. TI Environmental Gestagens Activate Fathead Minnow (Pimephales promelas) Nuclear Progesterone and Androgen Receptors in Vitro SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID STEROID-HORMONES; PHARMACOLOGICAL CHARACTERIZATION; SYNTHETIC PROGESTINS; EXPRESSION ANALYSIS; TRENBOLONE ACETATE; MEIOTIC MATURATION; OOCYTE MATURATION; WASTE-WATER; FISH; ESTROGEN AB Gestagen is a collective term for endogenous and synthetic progesterone receptor (PR) ligands. In teleost fishes, 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (DHP) and 17 alpha,20 beta,21-trihydroxy-4-pregnen-3-one (20 beta-S) are the predominant progestogens, whereas in other vertebrates the major progestogen is progesterone (P4). Progestins are components of human contraceptives and hormone replacement pharmaceuticals and, with P4, can enter the environment and alter fish and amphibian reproductive health. In this study, our primary objectives were to clone the fathead minnow (FHM) nuclear PR (nPR), to develop an in vitro assay for FHM nPR transactivation, and to screen eight gestagens for their ability to transactivate FHM nPR. We also investigated the ability of these gestagens to transactivate FHM androgen receptor (AR). Fish progestogens activated FHM nPR, with DHP being more potent than 20 beta-S. The progestin drospirenone and P4 transactivated the FHM nPR, whereas five progestins and P4 transactivated FHM AR, all at environmentally relevant concentrations. Progestins are designed to activate human PR, but older generation progestins have unwanted androgenic side effects in humans. In FHMs, several progestins proved to be strong agonists of AR. Here, we present the first mechanistic evidence that environmental gestagens can activate FHM nPR and AR, suggesting that gestagens may affect phenotype through nPR- and AR-mediated pathways. C1 [Ellestad, Laura E.; Chambers, Ian G.; Farmer, Jennifer L.; Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. [Cardon, Mary; Hartig, Phillip; Wilson, Vickie] US EPA, ORD NHEERL, Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA. [Stevens, Kyle; Villeneuve, Daniel L.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. RP Orlando, EF (reprint author), Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. EM eorlando@umd.edu OI Wilson, Vickie/0000-0003-1661-8481 FU Morris Animal Foundation [D12ZO-046] FX We thank J. Cavallin, M. Severson, and K. Jensen for their assistance and the Morris Animal Foundation for a grant to E.F.O. and L.E.E. (D12ZO-046). A special thank you to Dr. Peter Thomas for his encouragement and advice. The research described in this article has been reviewed by the U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 59 TC 20 Z9 20 U1 9 U2 63 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2014 VL 48 IS 14 BP 8179 EP 8187 DI 10.1021/es501428u PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AL6FH UT WOS:000339227500062 PM 24911891 ER PT J AU Thomas, RB Kirisits, MJ Lye, DJ Kinney, KA AF Thomas, Russell B. Kirisits, Mary Jo Lye, Dennis J. Kinney, Kerry A. TI Rainwater harvesting in the United States: a survey of common system practices SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Rainwater; Harvesting; Survey; Cistern storage tanks; Catchment; Drinking water ID DIFFERENT ROOFING MATERIALS; TANKS; QUALITY; WATER; AUSTRALIA AB Rainwater harvesting (RWH) systems in the United States vary in terms of design and operation. To better understand common practices in the RWH community and motivation for collecting harvested rainwater, an electronic survey was used to poll members of the American Rainwater Catchment Systems Association (ARCSA). Two hundred and twenty-two members of ARCSA responded to the survey; the responses were representative of approximately 2700 RWH systems across the United States that the respondents own, have installed, or have observed in the field. Survey questions focused on system setup, catchment materials (for the roof, cistern storage tank, gutters, and downspouts), motivation for harvesting rainwater, uses for the water, treatment methods, and water quality testing practices. Results indicate that composite asphalt shingles and metal are the most commonly used roofing materials for RWH, and polyethylene is the most common cistern material for the surveyed population. The most commonly reported use for harvested rainwater was irrigation although greater than 25% of the respondents use their rainwater for potable purposes. Of the potable users, greater than 70% utilize ultraviolet (UV) light as their primary treatment method, and approximately 21% conduct no water quality testing. This survey provides critical data about current non-potable and potable RWH practices in the United States and can be used to guide future RWH research. In particular, the low frequency of water quality testing and the efficacy of UV treatment should be investigated further as the number of RWH systems installed in the United States and elsewhere continues to grow. Published by Elsevier Ltd. C1 [Thomas, Russell B.; Kirisits, Mary Jo; Kinney, Kerry A.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA. [Lye, Dennis J.] US EPA, Water Supply Water Resources Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Kinney, KA (reprint author), Univ Texas Austin, Dept Civil Architectural & Environm Engn, 301 East Dean Keeton St,Stop 1786, Austin, TX 78712 USA. EM kakinney@mail.utexas.edu NR 24 TC 5 Z9 6 U1 4 U2 62 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD JUL 15 PY 2014 VL 75 BP 166 EP 173 DI 10.1016/j.jclepro.2014.03.073 PG 8 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AJ7EP UT WOS:000337860300017 ER PT J AU Huang, RL Sakamuru, S Martin, MT Reif, DM Judson, RS Houck, KA Casey, W Hsieh, JH Shockley, KR Ceger, P Fostel, J Witt, KL Tong, WD Rotroff, DM Zhao, TG Shinn, P Simeonov, A Dix, DJ Austin, CP Kavlock, RJ Tice, RR Xia, MH AF Huang, Ruili Sakamuru, Srilatha Martin, Matt T. Reif, David M. Judson, Richard S. Houck, Keith A. Casey, Warren Hsieh, Jui-Hua Shockley, Keith R. Ceger, Patricia Fostel, Jennifer Witt, Kristine L. Tong, Weida Rotroff, Daniel M. Zhao, Tongan Shinn, Paul Simeonov, Anton Dix, David J. Austin, Christopher P. Kavlock, Robert J. Tice, Raymond R. Xia, Menghang TI Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway SO SCIENTIFIC REPORTS LA English DT Article ID BREAST-CANCER CELLS; IN-VITRO ASSAYS; PYRETHROID INSECTICIDES; ANTIESTROGENIC ACTIVITY; ANDROGENIC ACTIVITY; IONIC LIQUIDS; HUMAN HEALTH; CHEMICALS; PHYTOESTROGENS; MECHANISMS AB The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ER alpha) agonist and antagonist activity using two types of ER reporter gene cell lines, one with an endogenous full length ER alpha (ER-luc; BG1 cell line) and the other with a transfected partial receptor consisting of the ligand binding domain (ER-bla; ER alpha beta-lactamase cell line), in a quantitative high-throughput screening (qHTS) format. The ability of the two assays to correctly identify ER alpha agonists and antagonists was evaluated using a set of 39 reference compounds with known ERa activity. Although both assays demonstrated adequate (i.e. 80%) predictivity, the ER-luc assay was more sensitive and the ER-bla assay more specific. The qHTS assay results were compared with results from previously published ER alpha binding assay data and showed >80% consistency. Actives identified from both the ER-bla and ER-luc assays were analyzed for structure-activity relationships (SARs) revealing known and potentially novel ERa active structure classes. The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERa signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals. C1 [Huang, Ruili; Sakamuru, Srilatha; Zhao, Tongan; Shinn, Paul; Simeonov, Anton; Austin, Christopher P.; Xia, Menghang] NIH, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA. [Martin, Matt T.; Reif, David M.; Judson, Richard S.; Houck, Keith A.; Rotroff, Daniel M.; Dix, David J.; Kavlock, Robert J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Casey, Warren; Hsieh, Jui-Hua; Shockley, Keith R.; Fostel, Jennifer; Witt, Kristine L.; Tice, Raymond R.] NIEHS, Div Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Ceger, Patricia] ILS Inc, Res Triangle Pk, NC 27709 USA. [Tong, Weida] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. RP Huang, RL (reprint author), NIH, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA. EM huangru@mail.nih.gov OI Judson, Richard/0000-0002-2348-9633; Reif, David/0000-0001-7815-6767 FU Intramural Research Programs of the National Toxicology Program [Y2-ES-7020-01]; National Institute of Environmental Health Sciences; U.S. Environmental Protection Agency [Y3-HG-7026-03]; National Center for Advancing Translational Sciences, National Institutes of Health FX This work was supported by the Intramural Research Programs of the National Toxicology Program (Interagency agreement #Y2-ES-7020-01), the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency (Interagency Agreement #Y3-HG-7026-03), and the National Center for Advancing Translational Sciences, National Institutes of Health. We would also like to thank Samuel Michael for assisting with the screens, Misha Itkin and Danielle VanLeer for compound management, William Leister for the Tox21 10K library quality control, and Drs. Kevin Crofton, Rusty Thomas and John Bucher for critical review of this manuscript. The views expressed in this article are those of the authors and do not necessarily reflect the statements, opinions, views, conclusions, or policies of the National Institute of Environmental Health Sciences, National Center for Advancing Translational Sciences, National Institutes of Health, U.S. Environmental Protection Agency, or the United States government. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 56 TC 27 Z9 29 U1 4 U2 35 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUL 11 PY 2014 VL 4 AR 5664 DI 10.1038/srep05664 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AL0PJ UT WOS:000338828500005 PM 25012808 ER PT J AU Krueger, WS Hilborn, ED Converse, RR Wade, TJ AF Krueger, Whitney S. Hilborn, Elizabeth D. Converse, Reagan R. Wade, Timothy J. TI Drinking water source and human Toxoplasma gondii infection in the United States: a cross-sectional analysis of NHANES data SO BMC PUBLIC HEALTH LA English DT Article DE Nutrition surveys; Toxoplasma; Drinking water; Water wells; Cross-sectional studies ID ACQUIRED TOXOPLASMOSIS; RISK-FACTORS; DISORDERS; OOCYSTS; HEALTH; SEROPREVALENCE; TRANSMISSION; OUTBREAK; BEHAVIOR; DISEASES AB Background: Toxoplasma gondii imparts a considerable burden to public health. Human toxoplasmosis can be life-threatening in immunocompromised individuals, has been associated with psychiatric disorders, and can cause severe congenital pathologies, spontaneous abortion, or stillbirth. Environmental modes of transmission contributing to the incidence of human toxoplasmosis are poorly understood. We sought to examine National Health and Nutrition Examination Survey (NHANES) data for risk factors associated with T. gondii seroprevalence. Methods: T. gondii serology results reported for Continuous NHANES survey years 1999-2004 and 2009-10 were examined. To explore associations with toxoplasmosis seropositivity, covariates of interest were selected a priori, including source and home treatment of tap water. Associations between potential risk factors and evidence of IgG antibodies against T. gondii were assessed using multivariable logistic regression. Results: Among 23,030 participants with available T. gondii serology across 8 years of continuous NHANES survey data (1999-2004; 2009-2010), persons born outside the United States were significantly more likely to be seropositive, and seropositivity was inversely associated with years spent in the United States. Among US-born participants, participants with homes on well water ( both those who used at-home water treatment devices and those who did not), as well as participants with public/private company-provided tap water who did not use at-home water treatment devices, were significantly more likely to be seropositive compared to participants who used home treatment devices on tap water provided by a private or public water company. A comparative subpopulation analysis revealed age-adjusted seroprevalence among US-born persons 12-49 yrs old significantly declined to 6.6% (95% CI, 5.2-8.0) (P <0.0001) in 2009-10, compared to previously published reports for NHANES data from 1988-1994 (14.1%) and 1999-2004 (9.0%). Conclusions: Data suggests that T. gondii infections continue to decline in the United States, but the overall infection rate remains substantial at nearly 7%. Despite the limitations in the Continuous NHANES cross-sectional survey, the association between well water use and T. gondii infection warrants further research. C1 [Krueger, Whitney S.; Converse, Reagan R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Krueger, Whitney S.; Hilborn, Elizabeth D.; Converse, Reagan R.; Wade, Timothy J.] US EPA, Environm Publ Hlth Div, Off Res & Dev, Chapel Hill, NC 27599 USA. RP Wade, TJ (reprint author), US EPA, Environm Publ Hlth Div, Off Res & Dev, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM wade.tim@epa.gov FU Internship/Research Participation Program at the Office of Research and Development; U.S. Environmental Protection Agency; Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and EPA FX This project was supported in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and EPA. NR 39 TC 7 Z9 7 U1 1 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JUL 10 PY 2014 VL 14 AR 711 DI 10.1186/1471-2458-14-711 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AL7EP UT WOS:000339296300003 PM 25012250 ER PT J AU Wallace, RB Baumann, H Grear, JS Aller, RC Gobler, CJ AF Wallace, Ryan B. Baumann, Hannes Grear, Jason S. Aller, Robert C. Gobler, Christopher J. TI Coastal ocean acidification: The other eutrophication problem SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE acidification; pH; estuary; hypoxia; calcium carbonate saturation; respiration ID LONG-ISLAND SOUND; ELEVATED CARBON-DIOXIDE; GULF-OF-MEXICO; SCALLOPS ARGOPECTEN-IRRADIANS; MARINE ECOSYSTEMS; CALCIUM-CARBONATE; UNITED-STATES; HYPOXIA; PH; ESTUARY AB Increased nutrient loading into estuaries causes the accumulation of algal biomass, and microbial degradation of this organic matter decreases oxygen levels and contributes towards hypoxia. A second, often overlooked consequence of microbial degradation of organic matter is the production of carbon dioxide (CO2) and a lowering of seawater pH. To assess the potential for acidification in eutrophic estuaries, the levels of dissolved oxygen (DO), pH, the partial pressure of carbon dioxide (pCO(2)), and the saturation state for aragonite (Omega(aragonite)) were horizontally and vertically assessed during the onset, peak, and demise of low oxygen conditions in systems across the northeast US including Narragansett Bay (RI), Long Island Sound (CT-NY), Jamaica Bay (NY), and Hempstead Bay (NY). Low pH conditions (<7.4) were detected in all systems during summer and fall months concurrent with the decline in DO concentrations. While hypoxic waters and/or regions in close proximity to sewage discharge had extremely high levels of pCO(2), (>3000 mu atm), were acidic pH (<7.0), and were undersaturated with regard to aragonite (Omega(aragonite) < 1), even near-normoxic but eutrophic regions of these estuaries were often relatively acidified (pH < 7.7) during late summer and/or early fall. The close spatial and temporal correspondence between DO and pH and the occurrence of extremes in these conditions in regions with the most intense nutrient loading indicated that they were primarily driven by microbial respiration. Given that coastal acidification is promoted by nutrient-enhanced organic matter loading and reaches levels that have previously been shown to negatively impact the growth and survival of marine organisms, it may be considered an additional symptom of eutrophication that warrants managerial attention. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Wallace, Ryan B.; Baumann, Hannes; Aller, Robert C.; Gobler, Christopher J.] SUNY Stony Brook, Sch Marine & Atmospher Sci, Southampton, NY 11968 USA. [Grear, Jason S.] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA. RP Gobler, CJ (reprint author), SUNY Stony Brook, Sch Marine & Atmospher Sci, 239 Montauk Hwy, Southampton, NY 11968 USA. EM christopher.gobler@stonybrook.edu OI Baumann, Hannes/0000-0002-4039-4230 FU NOAA's Ocean Acidification Program through National Centers for Coastal Ocean Science [NA12NOS4780148]; National Science Foundation (NSF) [1129622]; Chicago Community Trust FX This research was supported by NOAA's Ocean Acidification Program through award #NA12NOS4780148 from the National Centers for Coastal Ocean Science, the National Science Foundation (NSF # 1129622), and the Chicago Community Trust. NR 93 TC 50 Z9 51 U1 23 U2 139 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 EI 1096-0015 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD JUL 5 PY 2014 VL 148 BP 1 EP 13 DI 10.1016/j.ecss.2014.05.027 PG 13 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA AR8TI UT WOS:000343846800001 ER PT J AU Greenberg, MS Schoeters, I Wentsel, RS Charters, DW Mitchell, IA Zajdlik, B AF Greenberg, Marc S. Schoeters, Ilse Wentsel, Randall S. Charters, David W. Mitchell, Ian A. Zajdlik, Barry TI Regulatory Considerations for the Potential Development and Application of Metal Cleanup Values SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article AB This article addresses the regulatory issues associated with the application of recent data to support Registration, Evaluation, Authorisation and Restriction of Chemical substances (REACH) requirements in Europe and the use of metal-specific parameters by other countries to generate remediation values for metals in soil. The purposes of this article are to: 1) present approaches and advances developed over the last decade in Europe for the REACH regulation and proposed in Australia by the National Environment Protection Council, 2) review current US and Canadian regulatory practices on ecological soil cleanup values, and 3) evaluate the application of new scientific approaches, methods, and soil criteria development processes used in other countries. (C) 2013 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC. RP Greenberg, MS (reprint author), US EPA, OSWER, OSRTI, TIFSD,ERT, Edison, NJ 08837 USA. EM greenberg.marc@epa.gov NR 30 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2014 VL 10 IS 3 BP 401 EP 414 DI 10.1002/ieam.1481 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AK0VG UT WOS:000338133500010 PM 23966203 ER PT J AU Parks, AN Burgess, RM Ho, KT Ferguson, PL AF Parks, Ashley N. Burgess, Robert M. Ho, Kay T. Ferguson, P. Lee TI ON THE LIKELIHOOD OF SINGLE-WALLED CARBON NANOTUBES CAUSING ADVERSE MARINE ECOLOGICAL EFFECTS SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Editorial Material RP Parks, AN (reprint author), US EPA, Narragansett, RI 02882 USA. EM parks.ashley@epa.gov RI Ferguson, Lee/A-5501-2013 NR 6 TC 2 Z9 2 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2014 VL 10 IS 3 BP 472 EP 474 DI 10.1002/ieam.1540 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AK0VG UT WOS:000338133500018 ER PT J AU Eastmond, DA Keshava, N Sonawane, B AF Eastmond, David A. Keshava, Nagalakshmi Sonawane, Babasaheb TI Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH LA English DT Review DE Leukemia; Neoplasia; Carcinogens; Environmental agents; Risk assessment ID ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; THERAPY-RELATED MYELODYSPLASIA; ACUTE MYELOGENOUS LEUKEMIA; DNA TOPOISOMERASE-II; NON-HODGKIN-LYMPHOMA; ACUTE PROMYELOCYTIC LEUKEMIA; CHINESE OCCUPATIONAL POPULATION; LANGERHANS CELL HISTIOCYTOSIS; HEMATOPOIETIC STEM-CELLS AB Lymphohematopoietic neoplasia are one of the most common types of cancer induced by therapeutic and environmental agents. Of the more than 100 human carcinogens identified by the International Agency for Research on Cancer, approximately 25% induce leukemias or lymphomas. The objective of this review is to provide an introduction into the origins and mechanisms underlying lymphohematopoietic cancers induced by xenobiotics in humans with an emphasis on acute myeloid leukemia, and discuss the implications of this information for risk assessment. Among the agents causing lymphohematopoietic cancers, a number of patterns were observed. Most physical and chemical leukemia-inducing agents such as the therapeutic alkylating agents, topoisomerase II inhibitors, and ionizing radiation induce mainly acute myeloid leukemia through DNA-damaging mechanisms that result in either gene or chromosomal mutations. In contrast, biological agents and a few immunosuppressive chemicals induce primarily lymphoid neoplasms through mechanisms that involve alterations in immune response. Among the environmental agents examined, benzene was clearly associated with acute myeloid leukemia in humans, with increasing but still limited evidence for an association with lymphoid neoplasms. Ethylene oxide and 1,3-butadiene were linked primarily to lymphoid cancers. Although the association between formaldehyde and leukemia remains controversial, several recent evaluations have indicated a potential link between formaldehyde and acute myeloid leukemia. The four environmental agents examined in detail were all genotoxic, inducing gene mutations, chromosomal alterations, and/or micronuclei in vivo. Although it is clear that rapid progress has been made in recent years in our understanding of leukemogenesis, many questions remain for future research regarding chemically induced leukemias and lymphomas, including the mechanisms by which the environmental agents reviewed here induce these diseases and the risks associated with exposures to such agents. (C) 2014 Elsevier B.V. All rights reserved. C1 [Eastmond, David A.] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA. [Keshava, Nagalakshmi; Sonawane, Babasaheb] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Eastmond, DA (reprint author), Univ Calif Riverside, Dept Cell Biol & Neurosci, 2109 Biol Sci Bldg, Riverside, CA 92521 USA. EM david.eastmond@ucr.edu; keshava.nagu@epa.gov; Sonawane.Bob@epa.gov NR 351 TC 4 Z9 4 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5742 EI 1388-2139 J9 MUTAT RES-REV MUTAT JI Mutat. Res.-Rev. Mutat. Res. PD JUL-SEP PY 2014 VL 761 BP 40 EP 64 DI 10.1016/j.mrrev.2014.04.001 PG 25 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology GA AR1QW UT WOS:000343360700005 ER PT J AU Mobley, JD Dickerman, JC AF Mobley, J. David Dickerman, James C. TI COMMERCIAL UTILITY FLUE GAS DESULFURIZATION SYSTEMS SO MECHANICAL ENGINEERING LA English DT Editorial Material C1 [Mobley, J. David] US EPA, Ind Environm Res Lab, Res Triangle Pk, NC 27711 USA. [Dickerman, James C.] Radian Corp, Austin, TX USA. RP Mobley, JD (reprint author), US EPA, Ind Environm Res Lab, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0025-6501 EI 1943-5649 J9 MECH ENG JI Mech. Eng. PD JUL PY 2014 VL 136 IS 7 BP 28 EP 28 PG 1 WC Engineering, Mechanical SC Engineering GA AQ0PU UT WOS:000342486000015 ER PT J AU Olden, K Vulimiri, SV AF Olden, Kenneth Vulimiri, Suryanarayana V. TI Laboratory to Community: Chemoprevention Is the Answer SO CANCER PREVENTION RESEARCH LA English DT Article ID AFLATOXIN EXPOSURE; CANCER PREVENTION; RISK-FACTORS; TRITERPENOIDS; MORTALITY; DECLINE; TOXICOLOGY; DISEASE; CHINA AB In the current issue, Johnson and colleagues present exciting results, using biomarkers involved in aflatoxin B-1 (AFB(1))-induced hepatocarcinogenesis, as an example of a conceptual framework to target mechanisms of action in developing chemopreventive agents. Their innovative approach offers considerable promise for a field that has long been neglected. Proof-of-principle was demonstrated using a synthetic triterpenoid (CDDO-Im), which activates Nrf2 signal transduction pathway, inhibits formation of AFB(1)-induced DNA adducts and neoplastic hepatic foci, and alters the expression of genes associated with aflatoxin-mediated toxicity. (C) 2014 AACR. C1 US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Olden, K (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave, Washington, DC 20460 USA. EM olden.kenneth@epa.gov OI Vulimiri, Suryanarayana/0000-0003-3734-0036 NR 28 TC 2 Z9 2 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1940-6207 EI 1940-6215 J9 CANCER PREV RES JI Cancer Prev. Res. PD JUL PY 2014 VL 7 IS 7 BP 648 EP 652 DI 10.1158/1940-6207.CAPR-14-0124 PG 5 WC Oncology SC Oncology GA AO9TM UT WOS:000341700200002 PM 24934618 ER PT J AU White, BM Hall, ES Johnson, C AF White, Brandi M. Hall, Eric S. Johnson, Cheryl TI Environmental Health Literacy in Support of Social Action: An Environmental Justice Perspective SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID EXPOSURE; RISKS AB Different demographic groups in the U.S. experience unequal exposures to environmental hazards, i.e., 56% of the population in neighborhoods containing commercial waste facilities are people of color, with the associated poverty rates in those communities being 50% higher than in neighborhoods without commercial waste facilities. Developing programs to educate communities about environmental hazards affecting their health and quality of life is an essential component for a community to understand their true risk. The study described in this article examined the risk of environmental hazards as perceived by public housing residents and assessed the residents' preference for educational programs on environmental hazards. Residents perceived their risk factors in a broad context and they induded environmental health risks caused by pollutants along with physical safety concerns from crime and law enforcement interactions. The most trusted sources of information on environmental health include community organizations, trusted individuals in the community, and television programs. Recommendations for developing community-specific environmental health education programs include using sources of environmental health information that community members trust. C1 [White, Brandi M.] Med Univ S Carolina, Charleston, SC 29425 USA. [Hall, Eric S.] US EPA, Washington, DC USA. [Johnson, Cheryl] People Community Recovery, Chicago, IL USA. RP White, BM (reprint author), Med Univ S Carolina, 151 Rutledge Ave, Charleston, SC 29425 USA. EM whitbm@musc.edu FU J.B. Hawley Research Award in the Division of Epidemiology & Community Health at the University of Minnesota's School of Public Health FX This project would not have been possible without the contribution of residents of Altgeld Gardens-Murray Homes and staff/volunteers at PCR. The project was funded by the J.B. Hawley Research Award in the Division of Epidemiology & Community Health at the University of Minnesota's School of Public Health. NR 27 TC 1 Z9 1 U1 1 U2 9 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JUL-AUG PY 2014 VL 77 IS 1 BP 24 EP 29 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NV UT WOS:000341540800004 PM 25185324 ER PT J AU Garcia-Reyero, N Ekman, DR Habib, BT Villeneuve, DL Collette, TW Bencic, DC Ankley, GT Perkins, EJ AF Garcia-Reyero, Natalia Ekman, Drew R. Habib, B. Tanwir Villeneuve, Daniel L. Collette, Timothy W. Bencic, David C. Ankley, Gerald T. Perkins, Edward J. TI Integrated approach to explore the mechanisms of aromatase inhibition and recovery in fathead minnows (Pimephales promelas) SO GENERAL AND COMPARATIVE ENDOCRINOLOGY LA English DT Article DE Fathead minnow; Aromatase; Fadrozole; Transcriptomics; Metabolomics; Integrative analysis ID GROWTH-FACTOR-I; GENE-EXPRESSION; SEX-DIFFERENTIATION; ENERGY-METABOLISM; MOLECULAR-BIOLOGY; ORYZIAS-LATIPES; MESSENGER-RNA; SPARUS-AURATA; KGN CELLS; FISH AB Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estradiol synthesis that catalyzes the aromatization of androgens into estrogens in ovaries. Here, we used an integrated approach to assess the mechanistic basis of the direct effects of aromatase inhibition, as well as adaptation and recovery processes in fish. We exposed female fathead minnows (Pimephales promelas) via the water to 30 mu g/L of a model aromatase inhibitor, fadrozole, during 8 days (exposure phase). Fish were then held in clean water for 8 more days (recovery phase). Samples were collected at 1, 2, 4, and 8 days of both the exposure and the recovery phases. Transcriptomics, metabolomics, and network inference were used to understand changes and infer connections at the transcript and metabolite level in the ovary. Apical end-points directly indicative of endocrine function, such as plasma estradiol, testosterone, and vitellogenin levels were also measured. An integrated analysis of the data revealed changes in gene expression consistent with increased testosterone in fadrozole-exposed ovaries. Metabolites such as glycogen and taurine were strongly correlated with increased testosterone levels. Comparison of in vivo and ex vivo steroidogenesis data suggested the accumulation of steroidogenic enzymes, including aromatase, as a mechanism to compensate for aromatase inhibition. (C) 2014 Elsevier Inc. All rights reserved. C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Ekman, Drew R.; Collette, Timothy W.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA. [Habib, B. Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA. [Bencic, David C.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposures Res Div, Cincinnati, OH 45268 USA. [Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Garcia-Reyero, N (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM nvinas@igbb.msstate.edu FU US Army Environmental Quality Research Program [BAA 11-4838] FX We thank many scientists who contributed to generation of aspects of the data described herein, including N. Mueller, D. Martinovic, E. Mayknen, M. Kahl, K. Jensen, E. Durhan, and J. Cavallin. This work was funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. Although this paper has been approved for publication by the US EPA, the views expressed herein do not necessarily reflect EPA positions or policy. NR 77 TC 7 Z9 7 U1 1 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0016-6480 EI 1095-6840 J9 GEN COMP ENDOCR JI Gen. Comp. Endocrinol. PD JUL 1 PY 2014 VL 203 SI SI BP 193 EP 202 DI 10.1016/j.ygcen.2014.03.022 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AO1LJ UT WOS:000341073300022 PM 24704562 ER PT J AU Newbold, SC Marten, AL AF Newbold, Stephen C. Marten, Alex L. TI The value of information for integrated assessment models of climate change SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND MANAGEMENT LA English DT Article DE Climate change; Integrated assessment model; Value of information; Uncertainty; Climate sensitivity ID ENVIRONMENTAL ECONOMICS; OPTION VALUE; EMISSIONS; COSTS AB We estimate the value of information (VOI) for three key parameters of climate integrated assessment models (IAMs): marginal damages at low temperature anomalies, marginal damages at high temperature anomalies, and equilibrium climate sensitivity. Most empirical studies of climate damages have examined temperature anomalies up to 3 degrees C, while some recent theoretical studies emphasize the risks of "climate catastrophes," which depend on climate sensitivity and on marginal damages at higher temperature anomalies. We use a new IAM to estimate the VOI for each parameter over a range of assumed levels of study precision based on prior probability distributions calibrated using results from previous studies. We measure the VOI as the maximum fixed fraction of consumption that a social planner would be willing to pay to conduct a new study before setting a carbon tax. Our central results suggest that the VOI is greatest for marginal damages at high temperature anomalies. Published by Elsevier Inc. C1 [Newbold, Stephen C.; Marten, Alex L.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA. RP Newbold, SC (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave NW,EPA West 4316-T,MC 1809T, Washington, DC 20460 USA. EM newbold.steve@epa.gov; marten.alex@epa.gov NR 31 TC 2 Z9 2 U1 1 U2 17 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0095-0696 EI 1096-0449 J9 J ENVIRON ECON MANAG JI J.Environ.Econ.Manage. PD JUL PY 2014 VL 68 IS 1 BP 111 EP 123 DI 10.1016/j.jeem.2014.01.002 PG 13 WC Business; Economics; Environmental Studies SC Business & Economics; Environmental Sciences & Ecology GA AN6GU UT WOS:000340693800007 ER PT J AU Gray, WB Shadbegian, RJ Wang, CB Meral, M AF Gray, Wayne B. Shadbegian, Ronald J. Wang, Chunbei Meral, Merve TI Do EPA regulations affect labor demand? Evidence from the pulp and paper industry SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND MANAGEMENT LA English DT Article DE Cluster rule; Regulatory costs; Multimedia regulation; Employment effects ID ENVIRONMENTAL-REGULATION; CAUSAL INFERENCE; PRODUCTIVITY; TECHNOLOGY AB Any opinions and conclusions expressed herein are those of the author(s) and do not necessarily represent the views of the U.S. Census Bureau or the U.S. Environmental Protection Agency. All results have been reviewed to ensure that no confidential information is disclosed. We thank Wang Jin and Shital Sharma for excellent research assistance; we also thank Jim Davis at the Boston Research Data Center for his continued help, and Reed Walker and participants at the 2011 AERE Summer Conference and the Environmental Economics seminar at Harvard University's Kennedy School for helpful comments. Any remaining errors are ours. (C) 2014 Elsevier Inc. All rights reserved. C1 [Gray, Wayne B.] Clark Univ, Dept Econ, Worcester, MA 01610 USA. [Shadbegian, Ronald J.] EPA, Natl Ctr Environm Econ, Washington, DC USA. [Wang, Chunbei] Birmingham Southern Coll, Birmingham, AL USA. [Meral, Merve] Univ Massachusetts, Dartmouth, MA USA. RP Gray, WB (reprint author), Clark Univ, Dept Econ, 950 Main St, Worcester, MA 01610 USA. EM wgray@clarku.edu NR 26 TC 2 Z9 2 U1 2 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0095-0696 EI 1096-0449 J9 J ENVIRON ECON MANAG JI J.Environ.Econ.Manage. PD JUL PY 2014 VL 68 IS 1 BP 188 EP 202 DI 10.1016/j.jeem.2014.06.002 PG 15 WC Business; Economics; Environmental Studies SC Business & Economics; Environmental Sciences & Ecology GA AN6GU UT WOS:000340693800012 ER PT J AU Carey, JC Fulweiler, RW AF Carey, J. C. Fulweiler, R. W. TI Salt marsh tidal exchange increases residence time of silica in estuaries SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID BIOGENIC SILICA; NARRAGANSETT BAY; MARINE ECOSYSTEMS; DISSOLVED SILICA; SCHELDE ESTUARY; EUTROPHICATION; SEDIMENTS; DYNAMICS; NUTRIENT; IMPACT AB We present flux measurements of dissolved silicon (DSi), biogenic Si (BSi), and dissolved inorganic nitrogen (DIN) and phosphorus (DIP) on a temperate salt marsh in Narragansett Bay, Rhode Island, over neap, mid, and spring tide cycles during the spring and the summer seasons to determine the stoichiometry of marsh tidal export and the potential effect on Si availability in the receiving estuary. During the spring, when incoming waters were depleted in DSi (average 1.7 mu mol L-1), the marsh was a net sink of BSi (132 mol h(-1)) and a source of DSi (31 mol h(-1)) to the estuary. During this period, the DIN : DSi ratio of ebbing water was more than five times lower than that of flood water. Together, these data indicate that marsh nutrient fluxes "outwell'' nutrients in ratios that support spring diatom growth in Narragansett Bay. However, during the entire sampling period the marsh served as a net sink for both DSi and BSi, importing, on average, 14 mol DSi h(-1) and 86 mol BSi h(-1). We hypothesize that the net import and retention of Si by salt marshes provides a previously overlooked ecosystem service of increasing the residence time of Si in estuarine systems. In the absence of salt marshes, we calculate that 5.1 x 10(4) kmol of Si would be exported from the estuary during the growing season, decreasing the availability of Si in the system and having direct repercussions for phytoplankton species composition in nearby estuarine waters. C1 [Carey, J. C.; Fulweiler, R. W.] Boston Univ, Dept Earth & Environm, Boston, MA 02215 USA. [Fulweiler, R. W.] Boston Univ, Dept Biol, Boston, MA 02215 USA. RP Carey, JC (reprint author), US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM joanna.carey@gmail.com FU Estuarine Reserves Division, Office of Ocean and Coastal Resource Management, National Ocean Service, National Oceanographic and Atmospheric Association; Department of Earth and Environment at Boston University FX We are grateful for field assistance by Jules Opton-Himmel, Sarah Murphy, Kenneth Raposa, Daisy Durant, Margaret Notopoulos, and Sarah Sargent. In addition, we thank the following people for laboratory assistance: Amanda Vieillard, Elise Greenberg, Ashley Banks, Megan Ware, Suzann Duan, Samantha Giward, Marc Zemel, Courtney Zambory, and, especially, Ken Czapala. This research was conducted under an award from the Estuarine Reserves Division, Office of Ocean and Coastal Resource Management, National Ocean Service, National Oceanographic and Atmospheric Association Graduate Research Assistantship to J. C. Carey. We thank the Department of Earth and Environment at Boston University for partial funding support of J. C. Carey. We thank Cathy Wigand and two anonymous reviewers for their helpful comments that improved this manuscript. NR 44 TC 3 Z9 3 U1 5 U2 41 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0024-3590 EI 1939-5590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD JUL PY 2014 VL 59 IS 4 BP 1203 EP 1212 DI 10.4319/lo.2014.59.4.1203 PG 10 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA AM6AI UT WOS:000339942400009 ER PT J AU Yolton, K Cornelius, M Ornoy, A McGough, J Makris, S Schantz, S AF Yolton, Kimberly Cornelius, Marie Ornoy, Asher McGough, James Makris, Susan Schantz, Susan TI Exposure to neurotoxicants and the development of attention deficit hyperactivity disorder and its related behaviors in childhood SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Review DE ADHD; Childhood; Environmental exposure; Toxicants; Pregnancy; Postpartum ID PRENATAL ALCOHOL EXPOSURE; BLOOD LEAD LEVELS; ORGANOPHOSPHATE PESTICIDE EXPOSURE; GENE-ENVIRONMENT INTERACTIONS; MEXICAN-AMERICAN CHILDREN; INNER-CITY CHILDREN; SCHOOL-AGE-CHILDREN; DEFICIT/HYPERACTIVITY DISORDER; MATERNAL SMOKING; COCAINE EXPOSURE AB The purpose of this manuscript is to review the literature to determine evidence of associations between exposure to prenatal and postnatal environmental agents and the development of attention deficit hyperactivity disorder (ADHD) and related behaviors. A review of published research literature was conducted on associations between exposures to prenatal and postnatal cigarette smoke, prenatal exposure to alcohol, cocaine, and heroin, childhood exposure to lead, and prenatal exposure to organophosphate pesticides and outcomes of ADHD or behaviors related to ADHD. Review of the literature in these areas provides some evidence of associations between each of the exposures and ADHD-related behaviors, with the strongest evidence from prenatal cigarette and alcohol exposure and postnatal lead exposure. However, research on each exposure also produced evidence of weaknesses in these hypothesized links due to imprecise research methodologies and issues of confounding and inaccurate covariate adjustment. More rigorous studies are needed to provide definitive evidence of associations between each of these prenatal or postnatal exposures and the development of ADHD or symptoms of ADHD. Future studies need to clarify the underlying mechanisms between these exposures and the increased risk for ADHD and associated behaviors. More research is also needed utilizing study designs that include genetic information, as ADHD is highly heritable and there appear to be some protective mechanisms offered by certain genetic characteristics as evidenced in gene by environmental studies. Finally, while studies focusing on individual drugs and chemicals are an important first step, we cannot ignore the fact that children are exposed to combinations of drugs and chemicals, which can interact in complex ways with each other, as well as with the child's genetic makeup and psychosocial environment to influence ADHD risk. (C) 2014 Elsevier Inc. All rights reserved. C1 [Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Cornelius, Marie] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA. [Ornoy, Asher] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel. [McGough, James] Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA. [Makris, Susan] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Schantz, Susan] Univ Illinois, Coll Vet Med, Urbana, IL 61802 USA. [McGough, James] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Yolton, K (reprint author), Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Gen & Community Pediat, 3333 Burnet Ave,ML 7035, Cincinnati, OH 45229 USA. EM kimberly.yolton@cchmc.org FU Environmental Protection Agency [EO-11-H-001421] FX This work was partially supported by Environmental Protection Agency contract number EO-11-H-001421. The study sponsors made no contributions to study design, data collection, analysis, or interpretation. We thank Gale Richardson, Associate Editor for Neuro toxicology and Teratology, for her continued support and guidance during the compilation of this manuscript. NR 143 TC 8 Z9 9 U1 5 U2 39 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JUL-AUG PY 2014 VL 44 BP 30 EP 45 DI 10.1016/j.ntt.2014.05.003 PG 16 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AN0VL UT WOS:000340302000004 PM 24846602 ER PT J AU Garelick, H Miller, B Peijnenburg, W AF Garelick, Hemda Miller, Bradley Peijnenburg, Willie TI 44th IUPAC Congress: Environmental Chemistry Preface SO PURE AND APPLIED CHEMISTRY LA English DT Editorial Material DE emerging contaminants; impact assessment; IUPAC Congress-44; environmental chemistry; risk assessment; sustainable environmental management C1 [Garelick, Hemda] Middlesex Univ, Dept Nat Sci, London NW4 4BT, England. [Miller, Bradley] US EPA, Natl Enforcement Invest Ctr, Denver, CO 80225 USA. [Peijnenburg, Willie] Leiden Univ, Inst Environm Sci CML, NL-2300 RA Leiden, Netherlands. [Peijnenburg, Willie] Natl Inst Publ Hlth & Environm, Ctr Safety Subst & Prod, NL-3720 BA Bilthoven, Netherlands. RP Garelick, H (reprint author), Middlesex Univ, Dept Nat Sci, London NW4 4BT, England. EM h.garelick@mdx.ac.uk NR 0 TC 0 Z9 0 U1 1 U2 4 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0033-4545 EI 1365-3075 J9 PURE APPL CHEM JI Pure Appl. Chem. PD JUL PY 2014 VL 86 IS 7 BP 1083 EP 1084 DI 10.1515/pac-2014-5049 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA AM5CS UT WOS:000339873900001 ER PT J AU Kustov, LM Al-Abed, SR Virkutyte, J Kirichenko, OA Shuvalova, EV Kapustin, GI Mishin, IV Nissenbaum, VD Tkachenko, OP Finashina, ED AF Kustov, Leonid M. Al-Abed, Souhail R. Virkutyte, Jurate Kirichenko, Olga A. Shuvalova, Elena V. Kapustin, Gennady I. Mishin, Igor V. Nissenbaum, Vera D. Tkachenko, Olga P. Finashina, Elena D. TI Novel Fe-Pd/SiO2 catalytic materials for degradation of chlorinated organic compounds in water SO PURE AND APPLIED CHEMISTRY LA English DT Article DE catalysts; environmental chemistry; IUPAC Congress-44; nanomaterials ID VALENT IRON NZVI; THERMAL-DECOMPOSITION; BIMETALLIC CATALYSTS; ZEROVALENT IRON; DECHLORINATION; REMEDIATION; REDUCTION; PARTICLES; HYDRODECHLORINATION; TRICHLOROETHYLENE AB Novel reactive materials for catalytic degradation of chlorinated organic compounds in water at ambient conditions have been prepared on the basis of silica-supported Pd-Fe nanoparticles. Nanoscale Fe-Pd particles were synthesized inside porous silica supports using (NH4)(3)[Fe(C2O4)(3)] and [Pd(NH3)(4)]Cl-2 or Pd acetate as reaction precursors. According to temperature programmed reduction (TPR) studies, Pd introduction decreased the reduction temperature of the supported Fen+ species and nearly complete reduction with H-2 was observed at 400 degrees C. The successful surface loading with Pd was confirmed by X-ray photoelectron spectroscopy (XPS) analysis. Characterization of the samples by X-ray diffraction (XRD) and X-ray absorption near-edge structure + extended X-ray absorption fine structure (XANES + EXAFS) verified the presence of highly dispersed Pd-0, PdxFe1-x and Fe-0 phases. Reduction of the supported precursors in hydrogen resulted in materials that were highly active in perchloroethene (PCE) degradation and 2-chlorobiphenyl (2-ClBP) dechlorination. It was found that highly dispersed amorphous Fe-Pd bimetallic nanoparticles on silica support showed superior catalytic activity against PCE dechlorination in comparison to the free-standing Fe-Pd nanoparticles. For the samples with the same Fe content, the conversion of chlorinated organics as well as the stability increased with the Pd loading, e. g., the most effective degradation of PCEs and 2-ClBP was achieved at a Pd loading of 2.3-3.2 wt. %. C1 [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Kustov, Leonid M.; Kirichenko, Olga A.; Shuvalova, Elena V.; Kapustin, Gennady I.; Mishin, Igor V.; Nissenbaum, Vera D.; Tkachenko, Olga P.; Finashina, Elena D.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow, Russia. [Kustov, Leonid M.] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia. [Virkutyte, Jurate] Hammontree & Associates Ltd, North Canton, OH USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov RI Kirichenko, Olga/E-2725-2014 OI Kirichenko, Olga/0000-0003-4068-5289 FU International Science and Technology Center in Moscow, Russia FX Although US EPA contributed to this article, the research presented was not performed by or funded by US EPA and was not subject to US EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent US EPA's views or policies. This work was partially funded through the International Science and Technology Center in Moscow, Russia. Paper has not been subjected to internal policy review of EPA. Therefore, the research results presented herein do not necessarily reflect the views of EPA or its policy. NR 32 TC 6 Z9 6 U1 0 U2 31 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0033-4545 EI 1365-3075 J9 PURE APPL CHEM JI Pure Appl. Chem. PD JUL PY 2014 VL 86 IS 7 BP 1141 EP 1158 DI 10.1515/pac-2014-0207 PG 18 WC Chemistry, Multidisciplinary SC Chemistry GA AM5CS UT WOS:000339873900007 ER PT J AU Devlin, RB Smith, CB Schmitt, MT Rappold, AG Hinderliter, A Graff, D Carraway, MS AF Devlin, Robert B. Smith, Candice B. Schmitt, Michael T. Rappold, Ana G. Hinderliter, Alan Graff, Don Carraway, Martha Sue TI Controlled Exposure of Humans with Metabolic Syndrome to Concentrated Ultrafine Ambient Particulate Matter Causes Cardiovascular Effects SO TOXICOLOGICAL SCIENCES LA English DT Article DE particulate matter; Human; Clinical study; Heart rate variability ID HEART-RATE-VARIABILITY; DIESEL EXHAUST INHALATION; CORONARY-ARTERY-DISEASE; AIR-POLLUTION; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE; OXIDATIVE STRESS; ELDERLY SUBJECTS; HEALTHY-ADULTS; PARTICLES AB Many studies have reported associations between air pollution particles with an aerodynamic diameter < 2.5 mu m (fine particulate matter (PM)) and adverse cardiovascular effects. However, there is an increased concern that so-called ultrafine PM which comprises the smallest fraction of fine PM (aerodynamic diameter < 0.1 mu m) may be disproportionately toxic relative to the 0.1-2.5 mu m fraction. Ultrafine PM is not routinely measured in state monitoring networks and is not homogenously dispersed throughout an airshed but rather located in hot spots such as near combustion sources (e.g., roads), making it difficult for epidemiology studies to associate exposure to ultrafine PM with adverse health effects. Thirty four middle-aged individuals with metabolic syndrome were exposed for 2 h while at rest in a randomized crossover design to clean air and concentrated ambient ultrafine particles (UCAPS) for 2 h. To further define potential risk, study individuals carrying the null allele for GSTM1 (a prominent antioxidant gene) were identified by genotyping. Blood was obtained immediately prior to exposure, and at 1 and 20 h afterward. Continuous Holter monitoring began immediately prior to exposure and continued for 24 h. Based on changes we observed in previous CAPS studies, we hypothesized that ultrafine CAPS would cause changes in markers of blood inflammation and fibrinolysis as well as changes in heart rate variability and cardiac repolarization. GSTM1 null individuals had altered cardiac repolarization as seen by a change in QRS complexity following exposure to UCAPS and both the entire study population as well as GSTM1 null individuals had increased QT duration. Blood plasminogen and thrombomodulin were decreased in the whole population following UCAPS exposure, whereas C-reactive protein (CRP) and SAA were increased. This controlled human exposure study is the first to show that ambient ultrafine particles can cause cardiovascular changes in people with metabolic syndrome, which affects nearly a quarter of the U.S. adult population. C1 [Devlin, Robert B.; Smith, Candice B.; Schmitt, Michael T.; Rappold, Ana G.; Graff, Don; Carraway, Martha Sue] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Hinderliter, Alan] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA. RP Devlin, RB (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, MD 58D, Res Triangle Pk, NC 27711 USA. EM devlin.robert@epa.gov FU Environmental Protection Agency (EPA) FX Environmental Protection Agency (EPA) (to the authors, who are EPA employees). NR 58 TC 15 Z9 17 U1 1 U2 22 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JUL PY 2014 VL 140 IS 1 BP 61 EP 72 DI 10.1093/toxsci/kfu063 PG 12 WC Toxicology SC Toxicology GA AM3AB UT WOS:000339722100007 PM 24718702 ER PT J AU Snow, SJ Cheng, W Wolberg, AS Carraway, MS AF Snow, S. J. Cheng, W. Wolberg, A. S. Carraway, M. S. TI Air Pollution Upregulates Endothelial Cell Procoagulant Activity via Ultrafine Particle-Induced Oxidant Signaling and Tissue Factor Expression SO TOXICOLOGICAL SCIENCES LA English DT Article DE air pollution; NADPH oxidases; reactive oxygen species; tissue factor; thrombin generation ID SMOOTH-MUSCLE CELLS; OXIDATIVE STRESS; PARTICULATE MATTER; NADPH OXIDASES; MYOCARDIAL-INFARCTION; NAD(P)H OXIDASE; HEART-DISEASE; TERM EXPOSURE; THROMBOSIS; ATHEROSCLEROSIS AB Air pollution exposure is associated with cardiovascular events triggered by clot formation. Endothelial activation and initiation of coagulation are pathophysiological mechanisms that could link inhaled air pollutants to vascular events. Here we investigated the underlying mechanisms of increased endothelial cell procoagulant activity following exposure to soluble components of ultrafine particles (soluble UF). Human coronary artery endothelial cells (HCAEC) were exposed to soluble UF and assessed for their ability to trigger procoagulant activity in platelet-free plasma. Exposed HCAEC triggered earlier thrombin generation and faster fibrin clot formation, which was abolished by an anti-tissue factor (TF) antibody, indicating TF-dependent effects. Soluble UF exposure increased TF mRNA expression without compensatory increases in key anticoagulant proteins. To identify early events that regulate TF expression, we measured endothelial H2O2 production following soluble UF exposure and identified the enzymatic source. Soluble UF exposure increased endothelial H2O2 production, and antioxidants attenuated UF-induced upregulation of TF, linking the procoagulant responses to reactive oxygen species (ROS) formation. Chemical inhibitors and RNA silencing showed that NOX-4, an important endothelial source of H2O2, was involved in UF-induced upregulation of TF mRNA. These data indicate that soluble UF exposure induces endothelial cell procoagulant activity, which involves de novo TF synthesis, ROS production, and the NOX-4 enzyme. These findings provide mechanistic insight into the adverse cardiovascular effects associated with air pollution exposure. C1 [Snow, S. J.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA. [Cheng, W.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Wolberg, A. S.] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA. [Carraway, M. S.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27599 USA. RP Carraway, MS (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM carraway.martha@epa.gov OI Snow, Samantha/0000-0003-1812-8582 FU National Institutes of Health [CR833237, T32ES007126, R01HL094740] FX National Institutes of Health (CR833237 and T32ES007126 to S.J.S., R01HL094740 to A.S.W.). NR 45 TC 4 Z9 6 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JUL PY 2014 VL 140 IS 1 BP 83 EP 93 DI 10.1093/toxsci/kfu071 PG 11 WC Toxicology SC Toxicology GA AM3AB UT WOS:000339722100009 PM 24752501 ER PT J AU Meier, R Cascio, WE Ghio, AJ Wild, P Danuser, B Riediker, M AF Meier, Reto Cascio, Wayne E. Ghio, Andrew J. Wild, Pascal Danuser, Brigitta Riediker, Michael TI Associations of Short-Term Particle and Noise Exposures with Markers of Cardiovascular and Respiratory Health among Highway Maintenance Workers SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID HEART-RATE-VARIABILITY; PARTICULATE AIR-POLLUTION; ROAD TRAFFIC NOISE; DIFFUSION SIZE CLASSIFIER; CARDIAC AUTONOMIC CONTROL; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; HOSPITAL ADMISSIONS AB Background: Highway maintenance workers are constantly and simultaneously exposed to traffic-related particle and noise emissions, both of which have been linked to increased cardiovascular morbidity and mortality in population-based epidemiology studies. Objectives: We aimed to investigate short-term health effects related to particle and noise exposure. Methods: We monitored 18 maintenance workers, during as many as five 24-hr periods from a total of 50 observation days. We measured their exposure to fine particulate matter (diameter <= 2.5 mu m; PM2.5), ultrafine particles, and noise, and the cardiopulmonary health end points: blood pressure, proinflammatory and prothrombotic markers in the blood, lung function, and fractional exhaled nitric oxide (FeNO) measured approximately 15 hr after work. Heart rate variability was assessed during a sleep period approximately 10 hr after work. Results: PM2.5 exposure was significantly associated with C-reactive protein and serum amyloid A, and was negatively associated with tumor necrosis factor alpha. None of the particle metrics were significantly associated with von Willebrand factor or tissue factor expression. PM2.5 and work noise were associated with markers of increased heart rate variability, and with increased high-frequency and low-frequency power. Systolic and diastolic blood pressure on the following morning were significantly associated with noise exposure after work, and nonsignificantly associated with PM2.5. We observed no significant associations between any of the exposures and lung function or FeNO. Conclusions: Our findings suggest that exposure to particles and noise during highway maintenance work might pose a cardiovascular health risk. Actions to reduce these exposures could lead to better health for this population of workers. C1 [Meier, Reto; Wild, Pascal; Danuser, Brigitta; Riediker, Michael] Univ Lausanne, Inst Work & Hlth, Inst Univ Romand Sante Travail, Lausanne, Switzerland. [Meier, Reto; Wild, Pascal; Danuser, Brigitta; Riediker, Michael] Univ Geneva, Lausanne, Switzerland. [Cascio, Wayne E.; Ghio, Andrew J.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Wild, Pascal] Inst Res & Safety, Vandoeuvre Les Nancy, France. [Riediker, Michael] Inst Occupat Med, Singapore, Singapore. RP Riediker, M (reprint author), Inst Work & Hlth, Route Corniche 2, CH-1066 Lausanne, Switzerland. EM michael.riediker@alumni.ethz.ch RI Wild, Pascal/A-9585-2012; OI Wild, Pascal/0000-0003-3165-3808; Riediker, Michael/0000-0002-5268-864X FU Swiss National Science Foundation FX This study was funded by a grant from the Swiss National Science Foundation. NR 56 TC 12 Z9 12 U1 3 U2 47 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JUL PY 2014 VL 122 IS 7 BP 726 EP 732 DI 10.1289/ehp.1307100 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AL2AK UT WOS:000338928000023 PM 24647077 ER PT J AU Richmond-Bryant, J Meng, QY Davis, A Cohen, J Lu, SE Svendsgaard, D Brown, JS Tuttle, L Hubbard, H Rice, J Kirrane, E Vinikoor-Imler, LC Kotchmar, D Hines, EP Ross, M AF Richmond-Bryant, Jennifer Meng, Qingyu Davis, Allen Cohen, Jonathan Lu, Shou-En Svendsgaard, David Brown, James S. Tuttle, Lauren Hubbard, Heidi Rice, Joann Kirrane, Ellen Vinikoor-Imler, Lisa C. Kotchmar, Dennis Hines, Erin P. Ross, Mary TI The Influence of Declining Air Lead Levels on Blood Lead-Air Lead Slope Factors in Children SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID PARTICULATE MATTER; NATIONAL-HEALTH; US POPULATION; TRENDS; NHANES; SIZE; SOIL AB Background: It is difficult to discern the proportion of blood lead (PbB) attributable to ambient air lead (PbA), given the multitude of lead (Pb) sources and pathways of exposure. The PbB-PbA relationship has previously been evaluated across populations. This relationship was a central-consideration in the 2008 review of the Pb national ambient air quality standards. Objectives: The objectives of this study were to evaluate the relationship between PbB and PbA concentrations among children nationwide for recent years and to compare the relationship with those obtained from other studies in the literature. Methods: We merged participant-level data for PbB from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 9908 (1999-2008) with PbA data from the U.S. Environmental Protection Agency. We applied mixed-effects models, and we computed slope factor, d[PbB]/d[PbA] or the change in PbB per unit change in PbA, from the model results to assess the relationship between PbB and PbA. Results: Comparing the NHANES regression results with those from the literature shows that slope factor increased with decreasing PbA among children 0-11 years of age. Conclusion: These findings suggest that a larger relative public health benefit may be derived among children from decreases in PbA at low PbA exposures. Simultaneous declines in Pb from other sources, changes in PbA sampling uncertainties over time largely related to changes in the size distribution of Pb-bearing particulate matter, and limitations regarding sampling size and exposure error may contribute to the variability in slope factor observed across peer-reviewed studies. C1 [Richmond-Bryant, Jennifer; Davis, Allen; Svendsgaard, David; Brown, James S.; Kirrane, Ellen; Vinikoor-Imler, Lisa C.; Kotchmar, Dennis; Hines, Erin P.; Ross, Mary] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Meng, Qingyu; Lu, Shou-En] Rutgers State Univ, Sch Publ Hlth, Piscataway, NJ 08854 USA. [Cohen, Jonathan; Hubbard, Heidi] ICF Int, Fairfax, VA USA. [Tuttle, Lauren] Univ Texas Austin, Sch Architecture, Austin, TX 78712 USA. [Rice, Joann] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Meng, QY (reprint author), Rutgers State Univ, Sch Publ Hlth, Piscataway, NJ 08854 USA. EM mengqi@sph.rutgers.edu OI Hines, Erin Pias/0000-0002-2458-6267 FU U.S. Environmental Protection Agency (EPA) FX This research was supported by the U.S. Environmental Protection Agency (EPA). The research and this manuscript have been reviewed in accordance with U.S. EPA policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA. NR 24 TC 6 Z9 6 U1 3 U2 11 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JUL PY 2014 VL 122 IS 7 BP 754 EP 760 DI 10.1289/ehp.1307072 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AL2AK UT WOS:000338928000027 PM 24667492 ER PT J AU Ward, MDW Copeland, LB Lehmann, J Doerfler, DL Vesper, SJ AF Ward, Marsha D. W. Copeland, Lisa B. Lehmann, James Doerfler, Donald L. Vesper, Stephen J. TI Assessing the allergenic potential of molds found in water-damaged homes in a mouse model SO INHALATION TOXICOLOGY LA English DT Article DE Allergenicity; allergic asthma; house dust mite; mouse model; relative allergenicity ID DUST MITE EXTRACTS; NEUTROPHILIC INFLAMMATION; PENICILLIUM-CHRYSOGENUM; ASTHMA; RESPONSES; SENSITIZATION; ACTIVATION; EXPOSURE; CHILDREN; FUNGI AB Damp/moldy indoor environments, which have resulted from flooding events and may increase as a result of climate change, have been associated with asthma exacerbation. Certain molds found in significantly higher or lower concentrations in asthmatics' homes compared to control homes have been categorized as Group 1 (G1) and Group 2 (G2) molds, respectively. We have compared the allergic potential of selected G1/G2 molds to house dust mite (HDM) in a mouse model. BALB/c mice were exposed to mold (0-80 mu g) or HDM (20 mu g) extract by intratracheal aspiration either 4X over 4 weeks (allergenicity) or 1X (non-specific responses). Airflow limitation (methacholine challenge) was measured (Day 1) and serum and bronchoalveolar lavage fluid were collected (Day 2) after the final exposure. The G1 molds induced low-to-moderate responses and required higher doses to achieve antigen-specific IgE results similar to those induced by HDM. Compared to HDM responses, the G2 mold in this study required lower doses to induce a similar response. Acute exposure responses suggest some molds may exacerbate asthmatic responses. These studies demonstrate the differing capacities of molds to induce responses associated with allergic asthma, including differences in the threshold dose for allergy induction. Therefore, molds must be evaluated individually for allergic/asthmatic potential. These studies along with our previous studies with G1 (Stachybotrys chartarum)/G2 (Penicillium chrysogenum) molds suggest that the G1/G2 categorization is not indicative of allergic potential but they do not preclude this categorization's utility in determining unhealthy C1 [Ward, Marsha D. W.; Copeland, Lisa B.; Lehmann, James; Doerfler, Donald L.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Vesper, Stephen J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Ward, MDW (reprint author), US EPA, 109 TW Alexander Dr,MD B105-02, Res Triangle Pk, NC 27711 USA. EM ward.marsha@epa.gov NR 34 TC 2 Z9 2 U1 0 U2 9 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JUL PY 2014 VL 26 IS 8 BP 474 EP 484 DI 10.3109/08958378.2014.919043 PG 11 WC Toxicology SC Toxicology GA AL3EU UT WOS:000339009600004 PM 24987979 ER PT J AU Nash, MS Bradford, DF Wickham, JD Wade, TG AF Nash, Maliha S. Bradford, David F. Wickham, James D. Wade, Timothy G. TI Detecting change in landscape greenness over large areas: An example for New Mexico, USA SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Landscape; NDVI change; New Mexico; Local factors; Climate factors; Autoregression model ID ECOSYSTEM PERFORMANCE ANOMALIES; AVHRR NDVI DATA; CONTERMINOUS UNITED-STATES; VEGETATION DYNAMICS; SATELLITE DATA; AFRICAN SAHEL; NORTH-AMERICA; RIVER-BASIN; TIME-SERIES; DATA SET AB Monitoring and quantifying changes in vegetation cover over large areas using remote sensing can potentially detect broad-scale, slow changes (e.g., climate change over decades), as well as more local and rapid changes (e.g., fire, land development over weeks and years). A widely used indicator for detecting change in land cover is a measure of greenness, the Normalized Difference Vegetation Index (NDVI), derived from the Advanced Very High Resolution Radiometer (AVHRR). Detecting change in the NDVI, however, can be confounded by time-dependent patterns (e.g., seasonal effects) and variation associated with climate factors. In the present study we provide a method to address these confounding factors by evaluating the NDVI change using autoregression techniques that compare results from univariate (i.e., the NDVI vs. time) and multivariate analyses (the NDVI vs. time and climate variables) for similar to 314,000 1-km(2) pixels comprising the state of New Mexico over an 18-year period (1989-2006). The ability to detect NDVI trend was greatly improved by including climate variables in the multivariate analyses of the NDVI over time. Specifically, the fraction of pixels with a significant NDVI trend (mostly increasing) doubled from 5.2% of the pixels for the univariate autoregression analyses to 11.9% for the multivariate autoregression analyses. The comparisons of univariate and multivariate analyses also revealed that for most of the pixels with a significant NDVI trend in either analysis, the trend was consistent with changes in local factors rather than to broad-scale, slow changes (e.g., climate change); only 0.8% of the pixels had a significant NDVI trend associated with change in the climate variables. This latter finding is somewhat surprising given that several climate variables changed significantly over much of the state during the 18-year period, and the NDVI was significantly related to these variables in the multivariate autoregressions for much of the area. Close examination of several areas suggested that NDVI change in these areas was attributable to wildfires, agriculture, habitat restoration, and tree mortality associated with insect infestation. Published by Elsevier Inc. C1 [Nash, Maliha S.; Bradford, David F.] US EPA, Off Res & Dev, Landscape Ecol Branch, Las Vegas, NV 89119 USA. [Wickham, James D.; Wade, Timothy G.] US EPA, Off Res & Dev, Landscape Ecol Branch, Res Triangle Pk, NC 27711 USA. RP Nash, MS (reprint author), US EPA, Off Res & Dev, Landscape Ecol Branch, 944 E Harmon Ave, Las Vegas, NV 89119 USA. EM nash.maliha@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded the research described herein. This work was reviewed by EPA and approved for publication, but it may not necessarily reflect official Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 50 TC 6 Z9 8 U1 4 U2 49 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD JUL PY 2014 VL 150 BP 152 EP 162 DI 10.1016/j.rse.2014.04.023 PG 11 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA AL3OG UT WOS:000339037500013 ER PT J AU Gordon, CJ Johnstone, AFM Aydin, C AF Gordon, Christopher J. Johnstone, Andrew F. M. Aydin, Cenk TI Thermal Stress and Toxicity SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID DIFFERENT AMBIENT-TEMPERATURES; BODY-TEMPERATURE; THERMOREGULATORY RESPONSE; AIR-POLLUTION; HEAT-STRESS; INDUCED HYPOTHERMIA; OZONE EXPOSURE; ENVIRONMENTAL-TEMPERATURE; PERCUTANEOUS-ABSORPTION; LABORATORY MAMMALS AB Elevating ambient temperature above thermoneutrality exacerbates toxicity of most air pollutants, insecticides, and other toxic chemicals. On the other hand, safety and toxicity testing of toxicants and drugs is usually performed in mice and rats maintained at sub-thermoneutral temperatures of similar to 22 degrees C. When exposed to chemical toxicants under these relatively cool conditions, rodents typically undergo a regulated hypothermic response, characterized by preference for cooler ambient temperatures and controlled reduction in core temperature. Reducing core temperature delays the clearance of most toxicants from the body; however, a mild hypothermia also improves recovery and survival from the toxicant. Raising ambient temperature to thermoneutrality and above increases the rate of clearance of the toxicant but also exacerbates toxicity. Furthermore, heat stress combined with work or exercise is likely to worsen toxicity. Body temperature of large mammals, including humans, does not decrease as much in response to exposure to a toxicant. However, heat stress can nonetheless worsen toxic outcome in humans through a variety of mechanisms. For example, heat-induced sweating and elevation in skin blood flow accelerates uptake of some insecticides. Epidemiological studies suggest that thermal stress may exacerbate the toxicity of airborne pollutants such as ozone and particulate matter. Overall, translating results of studies in rodents to that of humans is a formidable task attributed in part to the interspecies differences in thermoregulatory response to the toxicants and to thermal stress. Published 2014. C1 [Gordon, Christopher J.; Johnstone, Andrew F. M.] US EPA, Tox Assessment Div, Natl Hlth Effects & Environm Res Lab, Res Triangle Pk, NC 27711 USA. [Aydin, Cenk] Uludag Univ, Fac Vet Med, Dept Physiol, Bursa, Turkey. RP Gordon, CJ (reprint author), US EPA, Tox Assessment Div, Natl Hlth Effects & Environm Res Lab, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov NR 100 TC 6 Z9 6 U1 0 U2 17 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JUL PY 2014 VL 4 IS 3 BP 995 EP 1016 DI 10.1002/cphy.c130046 PG 22 WC Physiology SC Physiology GA AK9SC UT WOS:000338766000003 PM 24944028 ER PT J AU Virkutyte, J Varma, RS AF Virkutyte, Jurate Varma, Rajender S. TI Eco-Friendly Magnetic Iron Oxide-Pillared Montmorillonite for Advanced Catalytic Degradation of Dichlorophenol SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE gamma-Fe2O3; Montmorillonite; Nanocomposite; Dichlorophenol; Degradation; TOC ID 2,4,5-TRICHLOROPHENOXYACETIC ACID; WATER; COMPOSITES; PHENOL AB Eco-friendly pillared montmorillonites, in which the pillars consist of iron oxide, are expected to have interesting and unusual magnetic properties that are applicable for environmental decontamination. A completely "green" and effective composite was synthesized using mild reaction conditions and benign products. The composite was characterized by scanning electron microscopy (SEM) equipped with EDS, transmission electron microscopy (TEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Catalytic activity was tested against the degradation of dichlorophenol (DCP) and was found that in the presence of peroxymonosulfate 85% of DCP disappeared in 2.5 h, whereas in the presence on hydrogen peroxide and peracetic acid nearly 50% and 70% of DCP, respectively, degraded in 3.5 h. TOC showed about 85% demineralization of the solution, which indicates a successful degradation of DCP. C1 [Virkutyte, Jurate] Hammontree & Associates Ltd, Fairfield, OH 45014 USA. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Virkutyte, J (reprint author), Hammontree & Associates Ltd, 4364 Whitmore Lane, Fairfield, OH 45014 USA. EM jvirkutyte@hammontree-engineers.com; Varma.Rajender@epa.gov FU National Risk Management Research Laboratory of U.S. Environmental Protection Agency (EPA), Cincinnati, OH FX This research was funded and conducted by the National Risk Management Research Laboratory of U.S. Environmental Protection Agency (EPA), Cincinnati, OH. This paper has not been subjected to internal policy review of the U.S. EPA. Therefore, the research results do not necessarily reflect the views of the agency or its policy. Mention of trade names and commercial products does not constitute endorsement or recommendation for use. NR 25 TC 13 Z9 13 U1 1 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2014 VL 2 IS 7 BP 1545 EP 1550 DI 10.1021/sc5002512 PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AK9LK UT WOS:000338748400002 ER PT J AU Veronesi, B Chorley, B Ward, W Simmons, SO Tennant, A Vallanat, B AF Veronesi, Bellina Chorley, Brian Ward, William Simmons, Steven O. Tennant, Alan Vallanat, Beena TI The Physicochemistry of Capped Nanosilver Predicts Its Biological Activity in Rat Brain Endothelial Cells (RBEC4) SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Sustainability; Nanosilver; Surface coating; Capping; Nanotoxicity; RBEC4; Blood brain barrier permeability; Transcellular resistance; Oxidative stress; Polyvinylpyrrolidone; PVP; Citrate; Physicochemistry; Endocytosis; NRF2; Vegfa; Slc1a2 ID RECEPTOR-MEDIATED ENDOCYTOSIS; COATED SILVER NANOPARTICLES; AMINO-ACID RELEASE; IN-VITRO; OXIDATIVE STRESS; LIPID-PEROXIDATION; IMPAIRS GLUTAMATE; SURFACE-CHARGE; BARRIER; TRANSPORT AB The "capping" or coating of nanosilver (nanoAg) extends its potency by limiting its oxidation and aggregation and stabilizing its size and shape. The ability of such coated nanoAg to alter the permeability and activate oxidative stress pathways in rat brain endothelial cells (RBEC4) was examined in the present study. The aggregate size and zeta potential of nanoAg with different sizes (10 and 75 nm) and coatings (PVP and citrate) were measured in cell culture media. Results indicated that both PVP-coated nanoAg were less electronegative than their citrate-coated counterparts over all exposure times, but only the PVP-coated 10 nm particles retained their initial electronegativity over all exposure times. In addition, only the PVP-coated particles retained their initial sizes throughout the 3 h measurement. PVP-coated 10 nm nanoAg selectively altered the permeability of RBEC4 monolayers within a 15 min exposure, although high resolution microscopy indicated that all coated nanoAg distributed throughout the cell's cytoplasm within the 3 h exposure. Reporter genes for AP-1 and NRF2/ARE, transfected into RBEC4, were selectively stimulated by the PVP-coated 10 nm nanoAg. Global gene arrays indicated that only PVP-coated nanoAg significantly altered gene expressions in the RBEC4, and those altered by 10 nm PVP-coated nanoAg were qualitatively similar but quantitatively much higher than those of its 75 nm counterpart. IPA and DAVID analyses indicated that the altered pathways affected by both PVP-coated nanoAg were primarily associated with a NRF2-mediated oxidative stress response, endocytosis, and bioenergetics. Together, these data suggest that the physicochemical features of surface coating aggregate size and surface charge contribute to capped nanoAg's permeability and oxidative stress responses in RBEC4. C1 [Veronesi, Bellina; Chorley, Brian; Simmons, Steven O.; Tennant, Alan] US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. [Ward, William; Vallanat, Beena] US EPA, Genom Res Core, Res Triangle Pk, NC 27711 USA. RP Veronesi, B (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. EM veronesi.bellina@epa.gov OI Simmons, Steven/0000-0001-9079-1069 NR 78 TC 1 Z9 1 U1 2 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2014 VL 2 IS 7 BP 1566 EP 1573 DI 10.1021/sc5000896 PG 8 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AK9LK UT WOS:000338748400005 ER PT J AU Markova, Z Novak, P Kaslik, J Plachtova, P Brazdova, M Jancula, D Siskova, KM Machala, L Marsalek, B Zboril, R Varma, R AF Markova, Zdenka Novak, Petr Kaslik, Josef Plachtova, Pavla Brazdova, Marketa Jancula, Daniel Siskova, Karolina Machalova Machala, Libor Marsalek, Blahos Zboril, Radek Varma, Rajender TI Iron(II,III)-Polyphenol Complex Nanoparticles Derived from Green Tea with Remarkable Ecotoxicological Impact SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Green synthesis; Green tea polyphenols; Iron-complexed nanoparticles; Ecotoxicity; Mossbauer spectroscopy ID VALENT IRON NANOPARTICLES; IRON(III) OXIDE; LEAF EXTRACTS; FE; CYANOBACTERIA; DEGRADATION; REMEDIATION; PALLADIUM; TOXICITY; REMOVAL AB There are several green methods available to synthesize iron-based nanoparticles using different bio-based reducing agents. Although their useful properties in degradation of organic dyes, chlorinated organics, or arsenic have been described earlier, their characterization has been ambiguous, and further research is needed in this area. Synthesis and characterization details on iron-based nanoparticles produced by green tea extract are described in detail; characterization was carried out by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and UV-vis spectrometry followed by ecotoxicological assay. XRD and TEM analyses revealed that iron forms amorphous nanosized particles with size depending on reaction time. Moreover, low-temperature Mossbauer spectroscopy confirmed progressive reduction of Fe3+ to Fe2+ during the reaction. Finally, the iron(II,III) nanoparticles prepared by green tea extract (GT-Fe nanoparticles) were found to have negative ecotoxicological impacts on important aquatic organisms such as cyanobacterium (Synechococcus nidulans), alga (Pseudokirchneriella subcapitata), and even invertebrate organisms (Daphnia magna). The EC50 values are 6.1 +/- 0.5 (72 h), 7.4 +/- 1.6 (72 h), and 21.9 +/- 4.3 (24 h) mg of Fe per L, respectively. C1 [Markova, Zdenka; Novak, Petr; Kaslik, Josef; Siskova, Karolina Machalova; Machala, Libor; Zboril, Radek] Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Markova, Zdenka; Novak, Petr; Kaslik, Josef; Siskova, Karolina Machalova; Machala, Libor; Zboril, Radek] Palacky Univ, Fac Sci, Dept Expt Phys, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Plachtova, Pavla; Brazdova, Marketa; Jancula, Daniel; Marsalek, Blahos] Acad Sci Czech Republic, Inst Bot, Brno 60200, Czech Republic. [Plachtova, Pavla; Brazdova, Marketa; Marsalek, Blahos] Masaryk Univ, Fac Sci, Res Ctr Tox Cpds Environm RECETOX, Brno 62500, Czech Republic. [Varma, Rajender] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Zboril, R (reprint author), Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Slechtitelu 11, Olomouc 78371, Czech Republic. EM radek.zboril@upol.cz; Varma.Rajender@epa.gov RI Plachtova, Pavla/M-8105-2014; Brazdova, Marketa/G-9801-2014; Zboril, Radek/F-5153-2015; OI Plachtova, Pavla/0000-0001-8294-5101; Zboril, Radek/0000-0002-3147-2196 FU Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.05/2.1.00/03.0058]; Operational Program Education for Competitiveness - European Social Fund [CZ.1.07/2.3.00/20.0155, CZ.1.07/2.3.00/20.0058]; Internal Student Grant IGA of Palacky University in Olomouc [PrF_2013_014]; Czech Ministry of Education [LO1214]; Academy of Sciences of the Czech Republic [RVO 67985939] FX The authors gratefully acknowledge the financial support by the Operational Program Research and Development for Innovations-European Regional Development Fund (project CZ.1.05/2.1.00/03.0058 of the Ministry of Education, Youth and Sports of the Czech Republic), Operational Program Education for Competitiveness - European Social Fund (projects CZ.1.07/2.3.00/20.0155 and CZ.1.07/2.3.00/20.0058), and Internal Student Grant IGA of Palacky University in Olomouc (PrF_2013_014). This research was also supported by the Czech Ministry of Education (LO1214) and the long-term research development project no. RVO 67985939 (Academy of Sciences of the Czech Republic) NR 40 TC 15 Z9 15 U1 13 U2 95 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2014 VL 2 IS 7 BP 1674 EP 1680 DI 10.1021/sc5001435 PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AK9LK UT WOS:000338748400018 ER PT J AU Shelke, SN Bankar, SR Mhaske, GR Kadam, SS Murade, DK Bhorkade, SB Rathi, AK Bundaleski, N Teodoro, OMND Zboril, R Varma, RS Gawande, MB AF Shelke, Sharad N. Bankar, Swapnil R. Mhaske, Ganesh R. Kadam, Samadhan S. Murade, Dinesh K. Bhorkade, Shashikant B. Rathi, Anuj K. Bundaleski, Nenad Teodoro, Orlando M. N. D. Zboril, Radek Varma, Rajender S. Gawande, Manoj B. TI Iron Oxide-Supported Copper Oxide Nanoparticles (Nanocat-Fe-CuO): Magnetically Recyclable Catalysts for the Synthesis of Pyrazole Derivatives, 4-Methoxyaniline, and Ullmann-type Condensation Reactions SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Magnetite-copper oxide; Recyclable catalysts; Pyrazole synthesis; Ullmann reaction; Benign media ID CUFE2O4 NANOPARTICLES; SOLVENT-FREE; MULTICOMPONENT REACTIONS; REUSABLE CATALYST; PD-CATALYST; WATER; CHEMISTRY; 1,2,3-TRIAZOLES; ALCOHOLS; HALIDES AB An efficient and benign protocol is reported for the synthesis of medicinally important pyrazole derivatives, 4-methoxyaniline, and Ullmann-type condensation reaction using magnetically separable and reusable magnetite-supported copper (nanocat-Fe-CuO) nanoparticles under mild conditions. Nanoparticles with average size of 20-30 nm have been synthesized using simple impregnation techniques in aqueous medium from readily available inexpensive starting materials and were recycled six times without loss in catalytic activity. C1 [Shelke, Sharad N.; Bankar, Swapnil R.; Mhaske, Ganesh R.; Kadam, Samadhan S.; Murade, Dinesh K.; Bhorkade, Shashikant B.] SSGM Coll, Dept Chem, Kopargaon 423601, MS, India. [Rathi, Anuj K.; Zboril, Radek; Gawande, Manoj B.] Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Bundaleski, Nenad; Teodoro, Orlando M. N. D.] Univ Nova Lisboa, Dept Phys, Fac Ciencias & Tecnol, Ctr Phys & Technol Res CeFITec, P-2829516 Caparica, Portugal. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Shelke, SN (reprint author), SSGM Coll, Dept Chem, Kopargaon 423601, MS, India. EM snshelke@yahoo.co.in; manoj.gawande@upol.cz RI Zboril, Radek/F-5153-2015; OI Teodoro, Orlando/0000-0002-3424-2847; Bundaleski, Nenad/0000-0002-5958-2282; Zboril, Radek/0000-0002-3147-2196 FU Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.05/2.1.00/03.0058, CZ.1.07/2.3.00/30.0041]; FCT-MEC [Pest-OE/FIS/UI0068/2011] FX The authors are thankful to the Director of SAW, Panjab University (Chandigarh, India), for the spectral analysis. We are also grateful to the Principal Dr. K. H. Shinde and Dr. A. B. Nikumbh (HOD), S.S.G.M. College, Kopargaon, Ahmednagar (MH), for providing research facilities and constant encouragement. The authors gratefully acknowledge support by the Operational Program Research and Development for Innovations European Regional Development Fund (project CZ.1.05/2.1.00/03.0058) and by the Operational Program Education for competitiveness European Social Fund (project CZ.1.07/2.3.00/30.0041) of the Ministry of Education, Youth and Sports of the Czech Republic as well as by the Portuguese Research Grant Pest-OE/FIS/UI0068/2011 through FCT-MEC. NR 59 TC 20 Z9 20 U1 1 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2014 VL 2 IS 7 BP 1699 EP 1706 DI 10.1021/sc500160f PG 8 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AK9LK UT WOS:000338748400021 ER PT J AU Nadagouda, MN Iyanna, N Lalley, J Han, C Dionysiou, DD Varma, RS AF Nadagouda, Mallikarjuna N. Iyanna, Nidhi Lalley, Jacob Han, Changseok Dionysiou, Dionysios D. Varma, Rajender S. TI Synthesis of Silver and Gold Nanoparticles Using Antioxidants from Blackberry, Blueberry, Pomegranate, and Turmeric Extracts SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Green synthesis; Noble metals; Antioxidants; Fruits; Spices ID GREEN SYNTHESIS; ANTIBACTERIAL ACTIVITY; BULK SYNTHESIS; NANOSTRUCTURES; BIOSYNTHESIS; CHEMISTRY; ROUTE AB Greener synthesis of Ag and Au nanoparticles is described using antioxidants from blackberry, blueberry, pomegranate, and turmeric extracts. The synthesized particles were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), particle size analysis, UV-vis spectroscopy, and thermogravimetric analysis. The XRD patterns indicated the formation of Ag and Au nanoparticles, and the results are in line with UV plasma resonance peaks. C1 [Nadagouda, Mallikarjuna N.; Lalley, Jacob] US EPA, ORD, NRMRL, WSWRD,TTEB, Cincinnati, OH 45268 USA. [Iyanna, Nidhi] William Mason High Sch, Mason, OH 45040 USA. [Lalley, Jacob; Han, Changseok; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Nadagouda, MN (reprint author), US EPA, ORD, NRMRL, WSWRD,TTEB, Cincinnati, OH 45268 USA. EM Nadagouda.Mallikarjuna@epa.gov; Varma.Rajender@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein. It has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 36 TC 28 Z9 29 U1 7 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2014 VL 2 IS 7 BP 1717 EP 1723 DI 10.1021/sc500237k PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AK9LK UT WOS:000338748400023 ER PT J AU Bhander, G Hutson, N Rosati, J Princiotta, F Pelt, K Staudt, J Petrusa, J AF Bhander, Gurbakhash Hutson, Nick Rosati, Jacky Princiotta, Frank Pelt, Kristine Staudt, Jim Petrusa, Jeffrey TI GHG mitigation options database (GMOD) and analysis tool SO INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL LA English DT Article DE Greenhouse gas; GHG database; Mitigation options; Industrial sectors; Mitigation costs; Emission costs AB There is a growing public consensus that the primary cause of climate change is anthropogenic greenhouse gas (GHG) emissions and that it will be necessary for the global community to use low-carbon technologies in both the energy and industrial sectors (IEA, 2013). As a result of the recent focus on GHG emissions, the U.S. Environmental Protection Agency (EPA) and state agencies are implementing policies and programs to quantify and regulate GHG emissions from sources in the United States. These policies and programs have generated a need for a reliable source of information regarding GHG mitigation options. In response to this need, EPA developed a comprehensive GHG mitigation options database (GMOD). The database is a repository of data on available GHG technologies in various stages of development for several industry sectors. It can also be used to assess the performance, costs, and limitations of various mitigation control options. This paper further describes the objectives of GMOD, the data available in GMOD, and functionality of GMOD as an analysis tool. In addition, examples are provided to demonstrate GMOD's usability and capabilities. A comparison of GMOD to other existing GHG mitigation databases is also provided along with the recommended next steps for GMOD. Published by Elsevier Ltd. C1 [Bhander, Gurbakhash; Rosati, Jacky; Princiotta, Frank] US EPA, Off Res & Dev, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27709 USA. [Hutson, Nick] US EPA, Off Qual & Stand, Sect Policies & Programs Div, Res Triangle Pk, NC 27709 USA. [Pelt, Kristine; Petrusa, Jeffrey] RTI Int, Res Triangle Pk, NC 27709 USA. [Staudt, Jim] Andover Technol Partners, N Andover, MA 01845 USA. RP Bhander, G (reprint author), US EPA, Air Pollut Technol Branch, Mail Code E-305-01,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM bhander.gurbakhash@epa.gov; hutson.nick@epa.gov; rosati.jacky@epa.gov; princiotta.frank@epa.gov; kpelt@rti.org; staudt@andovertechnology.com; petrusa@rti.org NR 11 TC 1 Z9 2 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1750-5836 EI 1878-0148 J9 INT J GREENH GAS CON JI Int. J. Greenh. Gas Control PD JUL PY 2014 VL 26 BP 1 EP 8 DI 10.1016/j.ijggc.2014.04.008 PG 8 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Energy & Fuels; Engineering, Environmental SC Science & Technology - Other Topics; Energy & Fuels; Engineering GA AL0LE UT WOS:000338817600001 ER PT J AU Schock, MR Cantor, AF Triantafyllidou, S Desantis, MK Scheckel, KG AF Schock, Michael R. Cantor, Abigail F. Triantafyllidou, Simoni Desantis, Michael K. Scheckel, Kirk G. TI Importance of pipe deposits to Lead and Copper Rule compliance SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article AB When Madison, Wis., exceeded the lead action level in 1992, residential and off-line tests suggested that lead release into the water was more complex than a lead solubility mechanism. Scale analyses (color/texture and mineralogical and elemental composition) of five excavated lead service lines (LSLs) revealed that accumulation of manganese (and iron) onto pipe walls had implications for lead corrosion by providing a high capacity sink for lead. Manganese that accumulated from source well water onto pipe scales (up to 10% by weight of scale composition) served to capture and eventually transport lead to consumer taps. In addition, manganese sometimes obstructed the predominance of an insoluble (and thus potentially protective) plattnerite [Pb(IV) solid] scale layer. Full LSL replacement in Madison achieved Lead and Copper Rule compliance and a major reduction in lead contamination and exposure, supplemented by unidirectional flushing of water mains and manganese control in the source well water. C1 [Schock, Michael R.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45220 USA. RP Schock, MR (reprint author), US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, 26 W Martin Luther King Dr, Cincinnati, OH 45220 USA. EM schock.michael@epa.gov OI Scheckel, Kirk/0000-0001-9326-9241 NR 5 TC 3 Z9 3 U1 3 U2 16 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD JUL PY 2014 VL 106 IS 7 BP 87 EP 88 DI 10.5942/jawwa.2014.106.0064 PG 2 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AK9OW UT WOS:000338757400018 ER PT J AU Chiarella, SE Soberanes, S Urich, D Morales-Nebreda, L Nigdelioglu, R Green, D Young, JB Gonzalez, A Rosario, C Misharin, AV Ghio, AJ Wunderink, RG Donnelly, HK Radigan, KA Perlman, H Chandel, NS Budinger, GRS Mutlu, GM AF Chiarella, Sergio E. Soberanes, Saul Urich, Daniela Morales-Nebreda, Luisa Nigdelioglu, Recep Green, David Young, James B. Gonzalez, Angel Rosario, Carmen Misharin, Alexander V. Ghio, Andrew J. Wunderink, Richard G. Donnelly, Helen K. Radigan, Kathryn A. Perlman, Harris Chandel, Navdeep S. Budinger, G. R. Scott Mutlu, Goekhan M. TI beta(2)-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article ID ACTING BETA-AGONISTS; OBSTRUCTIVE PULMONARY-DISEASE; ACUTE LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; HUMAN ALVEOLAR MACROPHAGES; DIESEL EXHAUST PARTICLES; HEART-RATE-VARIABILITY; SUBCHRONIC EXPOSURES; PLATELET-AGGREGATION; GLYCOPROTEIN-VI AB Acute exposure to particulate matter (PM) air pollution causes thrombotic cardiovascular events, leading to increased mortality rates; however, the link between PM and cardiovascular dysfunction is not completely understood. We have previously shown that the release of IL-6 from alveolar macrophages is required for a prothrombotic state and acceleration of thrombosis following exposure to PM. Here, we determined that PM exposure results in the systemic release of catecholamines, which engage the beta(2)-adrenergic receptor (beta(2)AR) on murine alveolar macrophages and augment the release of IL-6. In mice, beta(2)AR signaling promoted the development of a prothrombotic state that was sufficient to accelerate arterial thrombosis. In primary human alveolar macrophages, administration of a beta(2)AR agonist augmented IL-6 release, while the addition of a beta blocker inhibited PM-induced IL-6 release. Genetic loss or pharmacologic inhibition of the beta(2)AR on murine alveolar macrophages attenuated PM-induced IL-6 release and prothrombotic state. Furthermore, exogenous beta(2)AR agonist therapy further augmented these responses in alveolar macrophages through generation of mitochondrial ROS and subsequent increase of adenylyl cyclase activity. Together, these results link the activation of the sympathetic nervous system by beta(2)AR signaling with metabolism, lung inflammation, and an enhanced susceptibility to thrombotic cardiovascular events. C1 [Chiarella, Sergio E.; Soberanes, Saul; Urich, Daniela; Morales-Nebreda, Luisa; Nigdelioglu, Recep; Gonzalez, Angel; Rosario, Carmen; Wunderink, Richard G.; Donnelly, Helen K.; Radigan, Kathryn A.; Chandel, Navdeep S.; Budinger, G. R. Scott; Mutlu, Goekhan M.] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA. [Green, David] Northwestern Univ, Feinberg Sch Med, Div Hematol & Oncol, Chicago, IL 60611 USA. [Young, James B.] Northwestern Univ, Feinberg Sch Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA. [Misharin, Alexander V.; Perlman, Harris] Northwestern Univ, Feinberg Sch Med, Div Rheumatol, Chicago, IL 60611 USA. [Ghio, Andrew J.] US EPA, Res Triangle Pk, NC 27711 USA. RP Mutlu, GM (reprint author), Northwestern Univ, Feinberg Sch Med, 240 E Huron St,McGaw M-300, Chicago, IL 60611 USA. EM g-mutlu@northwestern.edu FU NIH [ES015024, ES013995, HL071643]; Northwestern University Clinical and Translational Sciences Institute (NUCATS) Center for Translational Innovation (CTI) Pilot Award [NCCR UL1 RR025741]; Veterans Administration FX This work was supported by NIH ES015024, ES013995, HL071643, the Northwestern University Clinical and Translational Sciences Institute (NUCATS) Center for Translational Innovation (CTI) Pilot Award (NCCR UL1 RR025741), and the Veterans Administration. The authors would like to thank Yiu-Kuen Chow and Nancy Foiles for their assistance with the measurement of catecholamines and plasma TAT levels, respectively, and Robert Schleimer for his careful review of the data. NR 75 TC 18 Z9 19 U1 0 U2 10 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 EI 1558-8238 J9 J CLIN INVEST JI J. Clin. Invest. PD JUL PY 2014 VL 124 IS 7 BP 2935 EP 2946 DI 10.1172/JCI75157 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA AK8OV UT WOS:000338688400020 PM 24865431 ER PT J AU Flick, RW Bencic, DC See, MJ Biales, AD AF Flick, Robert W. Bencic, David C. See, Mary J. Biales, Adam D. TI Sensitivity of the vitellogenin assay to diagnose exposure of fathead minnows to 17 alpha-ethynylestradiol SO AQUATIC TOXICOLOGY LA English DT Article DE 17 alpha-Ethynylestradiol (EE2); Vitellogenin; Estrogens; Fathead minnow; Biomarker ID TROUT ONCORHYNCHUS-MYKISS; PIMEPHALES-PROMELAS; 17-ALPHA-ETHINYLESTRADIOL; FISH; 17-BETA-ESTRADIOL; BIOMARKER; ESTROGENICITY; VARIABILITY; CHEMICALS; DYNAMICS AB Vitellogenin is frequently used as a biomarker of exposure to environmental estrogens due to its specificity and sensitivity. Appropriate incorporation of this biomarker into environmental monitoring and assessment necessitates evaluation of its critical performance parameters. In this study, we characterize the sensitivity of both vitellogenin gene (vtg) mRNA transcripts in liver and protein (VTG) in plasma over a range of concentrations and exposure durations. Male fathead minnows were exposed to 17 alpha-ethynylestradiol (EE2) in a flow-through system for 2, 4 and 7 days at multiple EE2 concentrations in order to provide information regarding the sensitivity of each of these biomarkers to diagnose exposure to this representative estrogen. Measurements of the expression of the vitellogenin gene and protein both reliably detected exposures to EE2 at concentrations of 5 ng/l and higher at all time points. Vtg mRNA and plasma VTG appear to have similar sensitivities, though the lower variability in VTG in control fish may make it more sensitive to small changes in expression compared to vtg. For lower concentrations, sensitivity may be improved by increasing exposure duration. A sample size of similar to 12 fish was sufficient in many cases to produce a statistically significant increase in vitellogenin. Larger sample sizes may provide more sensitivity at low concentrations, but detecting exposure to estrogens in the lower range of environmentally relevant concentrations may need larger sample sizes. These data will assist in designing experiments that have sufficient statistical power necessary to determine if fish have been exposed to estrogens. Published by Elsevier B.V. C1 [Flick, Robert W.; Bencic, David C.; See, Mary J.; Biales, Adam D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. RP Flick, RW (reprint author), US EPA, Natl Exposure Res Lab, AWBERC, MS 587,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM flick.robert@epa.gov; bencic.david@epa.gov; see.maryjean@epa.gov; biales.adam@epa.gov NR 36 TC 8 Z9 8 U1 4 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD JUL PY 2014 VL 152 BP 353 EP 360 DI 10.1016/j.aquatox.2014.04.026 PG 8 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA AK7KN UT WOS:000338607300039 PM 24813268 ER PT J AU Voelker, SL Brooks, R Meinzer, FC Roden, J Pazdur, A Pawelczyk, S Hartsough, P Snyder, K Plavcova, L Santrucek, J AF Voelker, Steven L. Brooks, Renee Meinzer, Frederick C. Roden, John Pazdur, Anna Pawelczyk, Slawomira Hartsough, Peter Snyder, Keirith Plavcova, Lenka Santrucek, Jiri TI Reconstructing relative humidity from plant delta 18O and delta D as deuterium deviations from the global meteoric water line SO ECOLOGICAL APPLICATIONS LA English DT Article DE cellulose; delta D; delta O-18; deuterium-excess; leaf vapor pressure; leaf water; relative humidity; water isotopes ID ISOTOPE CONCEPTUAL-MODEL; TREE-LEAF TEMPERATURES; STABLE-CARBON-ISOTOPE; STOMATAL CONDUCTANCE; OXYGEN ISOTOPES; RING CELLULOSE; UNITED-STATES; HYDROGEN; PRECIPITATION; RATIOS AB Cellulose delta O-18 and delta D can provide insights on climates and hydrological cycling in the distant past and how these factors differ spatially. However, most studies of plant cellulose have used only one isotope, most commonly delta O-18, resulting in difficulties partitioning variation in delta O-18 of precipitation vs. evaporative conditions that affect leaf water isotopic enrichment. Moreover, observations of pronounced diurnal differences from conventional steady-state model predictions of leaf water isotopic fractionation have cast some doubt on single isotope modeling approaches for separating precipitation and evaporation drivers of cellulose delta O-18 or delta D. We explore a dual isotope approach akin to the concept of deuterium-excess (d), to establish deuterium deviations from the global meteoric water line in leaf water (Delta d(l)) as driven by relative humidity (RH). To demonstrate this concept, we survey studies of leaf water delta O-18 and delta D in hardwood vs. conifer trees. We then apply the concept to cellulose delta O-18 and delta D using a mechanistic model of cellulose delta O-18 and delta D to reconstruct deuterium deviations from the global meteoric water line (Delta d(c)) in Quercus macrocarpa, Q. robur, and Pseudotsuga menziesii. For each species, Delta d(c) showed strong correlations with RH across sites. Delta d(c) agreed well with steady-state predictions for Q. macrocarpa, while for Q. robur, the relationship with RH was steeper than expected. The slope of Delta d(c) vs. RH of P. menziesii was also close to steady-state predictions, but Delta d(c) were more enriched than predicted. This is in agreement with our leaf water survey showing conifer Delta d(l) was more enriched than predicted. Our data reveal that applications of this method should be appropriate for reconstructing RH from cellulose delta O-18 and delta D after accounting for differences between hardwoods and conifers. Hence, Delta d(c) should be useful for understanding variability in RH associated with past climatic cycles, across regional climates, or across complex terrain where climate modeling is challenging. Furthermore, Delta d(c) and inferred RH values should help in constraining variation in source water delta O-18. C1 [Voelker, Steven L.; Roden, John] Southern Oregon Univ, Dept Biol, Ashland, OR 97520 USA. [Brooks, Renee] US EPA, NHEERL, Western Ecol Div, Corvallis, OR 97333 USA. [Meinzer, Frederick C.] US Forest Serv, USDA, Forestry Sci Lab, Corvallis, OR 97331 USA. [Pazdur, Anna; Pawelczyk, Slawomira] Silesian Tech Univ, Inst Phys, Dept Radioisotopes, PL-44100 Gliwice, Poland. [Hartsough, Peter] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Snyder, Keirith] ARS, USDA, Great Basin Rangelands Res Unit, Reno, NV 89512 USA. [Plavcova, Lenka] Univ Ulm, Inst Systemat Bot & Ecol, D-89081 Ulm, Germany. [Santrucek, Jiri] Univ South Bohemia, Dept Expt Plant Biol, Fac Sci, CZ-37005 Ceske Budejovice, Czech Republic. RP Voelker, SL (reprint author), Southern Oregon Univ, Dept Biol, 1250 Siskiyou Blvd, Ashland, OR 97520 USA. EM voelkerst@sou.edu RI Voelker, Steven/O-2909-2014; Santrucek, Jiri/G-9776-2014; OI Santrucek, Jiri/0000-0003-0430-5795; Brooks, Renee/0000-0002-5008-9774 FU National Science Foundation [DEB-0743882, AGS-1003601]; MIBA program through the International Atomic Energy Agency; GACR [P501-12-1261]; GAJU [143/2013/P] FX We appreciate the work of Kristen Falk, Lin Roden, Marie Simkova, Jiri Kveton., Martina Vrablova, Marie Hronkova, and Dasa Bastlova for assistance in the field and laboratory and IRMS analyses. Two anonymous reviewers provided valuable comments that improved the manuscript. Research by S. L. Voelker was supported by the National Science Foundation grants DEB-0743882 and AGS-1003601. L. Plavkova and J. Santrucek were supported in part by the MIBA program through the International Atomic Energy Agency, by GACR project #P501-12-1261, and GAJU project 143/2013/P. The manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and it has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or a recommendation for use. NR 74 TC 5 Z9 5 U1 6 U2 60 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1051-0761 EI 1939-5582 J9 ECOL APPL JI Ecol. Appl. PD JUL PY 2014 VL 24 IS 5 BP 960 EP 975 PG 16 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA AK0NJ UT WOS:000338109700006 PM 25154090 ER PT J AU Macedo, DR Hughes, RM Ligeiro, R Ferreira, WR Castro, MA Junqueira, NT Oliveira, DR Firmiano, KR Kaufmann, PR Pompeu, PS Callisto, M AF Macedo, Diego R. Hughes, Robert M. Ligeiro, Raphael Ferreira, Wander R. Castro, Miriam A. Junqueira, Nara T. Oliveira, Deborah R. Firmiano, Kele R. Kaufmann, Philip R. Pompeu, Paulo S. Callisto, Marcos TI The relative influence of catchment and site variables on fish and macroinvertebrate richness in cerrado biome streams SO LANDSCAPE ECOLOGY LA English DT Article DE Landscape ecology; Brazil; Savanna; Streams; Physical habitat structure; Anthropogenic pressures; Biological diversity; Multiple linear regression models; Partition of variance ID MULTIPLE SPATIAL SCALES; BIOTIC INTEGRITY; LAND-USE; BRAZILIAN CERRADO; BIOLOGICAL ASSEMBLAGES; HIERARCHICAL FRAMEWORK; COMMUNITY STRUCTURE; RIVER CONTINUUM; RUNNING WATERS; WESTERN USA AB Landscape and site-scale data analyses aid the interpretation of biological data and thereby help us develop more cost-effective natural resource management strategies. Our study focused on environmental influences on stream assemblages and we evaluated how three classes of environmental variables (geophysical landscape, land use and cover, and site habitat), influence fish and macroinvertebrate assemblage richness in the Brazilian Cerrado biome. We analyzed our data through use of multiple linear regression (MLR) models using the three classes of predictor variables alone and in combination. The four MLR models explained dissimilar amounts of benthic macroinvertebrate taxa richness (geophysical landscape R (2) a parts per thousand 35 %, land use and cover R (2) a parts per thousand 28 %, site habitat R (2) a parts per thousand 36 %, and combined R (2) a parts per thousand 51 %). For fish assemblages, geophysical landscape, land use and cover, site habitat, and combined models explained R (2) a parts per thousand 28 %, R (2) a parts per thousand 10 %, R (2) a parts per thousand 31 %, and R (2) a parts per thousand 47 % of the variability in fish species richness, respectively. We conclude that (1) environmental variables differed in the degree to which they explain assemblage richness, (2) the amounts of variance in assemblage richness explained by geophysical landscape and site habitat were similar, (3) the variables explained more variability in macroinvertebrate taxa richness than in fish species richness, and (4) all three classes of environmental variables studied were useful for explaining assemblage richness in Cerrado headwater streams. These results help us to understand the drivers of assemblage patterns at regional scales in tropical areas. C1 [Macedo, Diego R.; Hughes, Robert M.; Ligeiro, Raphael; Ferreira, Wander R.; Oliveira, Deborah R.; Firmiano, Kele R.; Callisto, Marcos] Univ Fed Minas Gerais, Dept Gen Biol, BR-31270901 Belo Horizonte, MG, Brazil. [Macedo, Diego R.] Brazilian Inst Geog & Stat, BR-30150310 Belo Horizonte, MG, Brazil. [Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97333 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA. [Castro, Miriam A.; Junqueira, Nara T.; Pompeu, Paulo S.] Univ Fed Lavras, Dept Biol, BR-37200000 Lavras, MG, Brazil. [Kaufmann, Philip R.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Corvallis, OR 97333 USA. RP Macedo, DR (reprint author), Univ Fed Minas Gerais, Dept Gen Biol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil. EM rodriguesmacedo@gmail.com; hughes.bob@amnisopes.com; ligeirobio@gmail.com; ferreirawr@gmail.com; miriambioufla@gmail.com; naratadini@yahoo.com.br; deborah.ufmg@gmail.com; kelerocha@gmail.com; kaufmann.phil@epa.gov; pompeu@ufla.br; callistom@ufmg.br RI Pompeu, Paulo/F-6696-2012; Macedo, Diego/G-2506-2015; Ligeiro, Raphael/K-7791-2015; Callisto, Marcos/O-4930-2015 OI Macedo, Diego/0000-0002-1178-4969; Ligeiro, Raphael/0000-0001-9717-5461; Callisto, Marcos/0000-0003-2341-4700 FU CEMIG-Programa Peixe Vivo; PD ANEEL-CEMIG [GT-487]; CAPES; CNPq; FAPEMIG; Fulbright Brasil; CNPq - Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) [302960/2011-2]; FAPEMIG - Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [FAPEMIG PPM-00077/13]; CNPq (CNPq) [306325/2011-0]; FAPEMIG [FAPEMIG PPM-00237/13] FX We received funding from CEMIG-Programa Peixe Vivo, P&D ANEEL-CEMIG (GT-487), CAPES, CNPq, FAPEMIG and Fulbright Brasil. MC was awarded a productivity in research grant by CNPq - Conselho Nacional de Desenvolvimento e Pesquisa (CNPq No. 302960/2011-2) and a Minas Gerais State Researcher Grant by FAPEMIG - Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG PPM-00077/13). PSP was awarded a productivity in research grant by CNPq (CNPq No. 306325/2011-0) and a Minas Gerais State Researcher Grant by FAPEMIG (FAPEMIG PPM-00237/13). Colleagues from the CEFET-MG, PUC-MG, UFLA and UFMG assisted with field collections and laboratory work. We are grateful for assistance in statistical design and site selection from Tony Olsen, Marc Weber, and Phil Larsen and we thank Randy Comeleo, Marc Weber, Bob Ozretich, and two anonymous journal reviewers for helpful reviews that improved our manuscript. This manuscript was subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 98 TC 14 Z9 16 U1 4 U2 46 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 EI 1572-9761 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD JUL PY 2014 VL 29 IS 6 BP 1001 EP 1016 DI 10.1007/s10980-014-0036-9 PG 16 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AK3NP UT WOS:000338331600007 ER PT J AU Lehrter, JC Fry, B Murrell, MC AF Lehrter, John C. Fry, Brian Murrell, Michael C. TI Microphytobenthos production potential and contribution to bottom layer oxygen dynamics on the inner Louisiana continental shelf SO BULLETIN OF MARINE SCIENCE LA English DT Article ID GULF-OF-MEXICO; BENTHIC MICROALGAE; HYPOXIA; SEDIMENTS; PHYTOPLANKTON; RESPIRATION; TRANSPORT; ESTUARY; REGION; ZONE AB To investigate the relative importance of microphytobenthos (MPB) oxygen (O-2) production on a river-dominated shelf, we made sediment core incubation measurements of MPB O-2 production and sediment O-2 consumption, and compared these to water-column measures of primary production and respiration during one spring and two summer cruises. Sites were located across a light attenuation (Kd) gradient on the inner Louisiana shelf (<25 m depth) with three sites on the eastern shelf and one site on the western shelf. MPB production rates were highest (range = 0.7-33.4 mmol O-2 m(-2) d(-1)) at the western site where light attenuation was lowest (range = 0.13-0.16 m(-1)). Near the river plumes, where Kd was higher (range = 0.17-0.64 m(-1)), MPB production was lower (range = 0-2.0 mmol m(-2) d(-1)) MPB production influenced the magnitude and direction of sediment O-2 exchanges at the western site and was observed to be a function of light availability. Overall, though, in comparison with integrated bottom layer production and respiration rates, MPB photosynthetic O-2 production as a percentage was small (range of means = 0%-2%) at the eastern shelf sites. At the western site, MPB production was larger, and more variable, 39% (SE 34%) of bottom layer O-2 production. Though based on a small data set, results suggest distinct differences between eastern and western shelf Kd and MPB contributions to bottom water O-2 due to proximity to the freshwater discharges of the Mississippi and Atchafalaya rivers. C1 [Lehrter, John C.; Murrell, Michael C.] US EPA, NHEERL, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Fry, Brian] Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. RP Lehrter, JC (reprint author), US EPA, NHEERL, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM lehrter.john@epa.gov FU US EPA, National Health and Environmental Effects Research Laboratory FX We thank D Beddick, R Devereux, DYates, G Craven, B Quarles, B Boyd, M Baustian, and L Oliver for helpful discussions and assisting with field and laboratory work. We thank the facilities staff at the Gulf Ecology Division for designing and constructing the sediment chambers and incubators. The efforts of the crew of the OSV BOLD are gratefully acknowledged. Reviews by three anonymous reviewers and the editor signifcantly improved this manuscript. The study was funded, reviewed, and approved for publication by the US EPA, National Health and Environmental Effects Research Laboratory; however, the contents are solely the views of the authors. Use of trade names or commercial products does not constitute endorsement by the US EPA. NR 29 TC 2 Z9 2 U1 0 U2 10 PU ROSENSTIEL SCH MAR ATMOS SCI PI MIAMI PA 4600 RICKENBACKER CAUSEWAY, MIAMI, FL 33149 USA SN 0007-4977 EI 1553-6955 J9 B MAR SCI JI Bull. Mar. Sci. PD JUL PY 2014 VL 90 IS 3 BP 765 EP 780 DI 10.5343/bms.2013.1050 PG 16 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA AJ9CG UT WOS:000338003800003 ER PT J AU Savitz, DA Klebanoff, MA Wellenius, GA Jensen, ET Longnecker, MP AF Savitz, David A. Klebanoff, Mark A. Wellenius, Gregory A. Jensen, Elizabeth T. Longnecker, Matthew P. TI Persistent organochlorines and hypertensive disorders of pregnancy SO ENVIRONMENTAL RESEARCH LA English DT Article DE Organochlorines; PCBs; DDT; Gestational hypertension; Preeclampsia ID PERFLUOROOCTANOIC ACID EXPOSURE; POLYCHLORINATED-BIPHENYLS; PREECLAMPSIA; BIRTH; ASSOCIATION; PRETERM AB Although there is indirect evidence to suggest that persistent organochlorines might increase risk of hypertensive disorders of pregnancy, there are no epidemiologic studies directly addressing this question. In this cohort study, sampled from the Collaborative Perinatal Project, 1933 women had complete data on organochlorine measurements, covariates, and pregnancy outcomes. Exposures to organochlorines were divided into quintiles, and levels were much higher in these patients recruited from 1959 to 1965 compared to levels in the general population at present. Among included women, 364 developed gestational hypertension (hypertension without proteinuria) and 131 developed preeclampsia (hypertension with proteinuria). We found essentially no association between serum DDE and total PCBs and risk of either gestational hypertension or preeclampsia. Results for other organochlorines showed varying patterns of results: DDT was inversely associated with risk of gestational hypertension (p for trend <0.001), B-Hexachlorocyclohexane and heptachlor epoxide were inversely related to gestational hypertension (p trend <0.01 and 0.10, respectively), dieldrin had a modestly positive association with gestational hypertension (p for trend = 0.12), and hexachlorobenzene, trans-nonachlor, and oxychlordane yielded results close to the null. Hexachlorobenzene showed an inverse association with preeclampsia (p for trend <0.001). The study suggests that persistent organochlorines present at historically high level are not likely to increase the risk of hypertensive disorders of pregnancy, suggesting that other toxicants that have similar biologic effects are also unlikely to do so. (C) 2014 Elsevier Inc. All rights reserved. C1 [Savitz, David A.; Wellenius, Gregory A.] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA. [Klebanoff, Mark A.] Ohio State Univ, Coll Med, Nationwide Childrens Hosp, Dept Pediat, Columbus, OH 43210 USA. [Klebanoff, Mark A.] Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA. [Jensen, Elizabeth T.; Longnecker, Matthew P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. RP Savitz, DA (reprint author), Brown Univ, Sch Publ Hlth, Dept Epidemiol, 47 George St,Room 302, Providence, RI 02912 USA. EM david_savitz@brown.edu; Mark.Klebanoff@nationwidechildrens.org; Gregory_wellenius@brown.edu; elizabeth.jensen@nih.gov; Longnecl@niehs.nih.gov RI Wellenius, Gregory/A-7105-2012; Jensen, Elizabeth/L-1466-2016; OI Wellenius, Gregory/0000-0003-0427-7376; Longnecker, Matthew/0000-0001-6073-5322 FU Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences FX This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences. This research was reviewed and approved by the National Institute of Environmental Health Sciences IRB and was found to be exempt from Institutional Review Board review at Brown University. NR 20 TC 5 Z9 5 U1 0 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD JUL PY 2014 VL 132 BP 1 EP 5 DI 10.1016/j.envres.2014.03.020 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AJ7FJ UT WOS:000337862300001 PM 24742720 ER PT J AU Vinikoor-Imler, LC Davis, JA Meyer, RE Messer, LC Luben, TJ AF Vinikoor-Imler, Lisa C. Davis, J. Allen Meyer, Robert E. Messer, Lynne C. Luben, Thomas J. TI Associations between prenatal exposure to air pollution, small for gestational age, and term low birthweight in a state-wide birth cohort SO ENVIRONMENTAL RESEARCH LA English DT Article DE Air pollution; Low birthweight; Ozone; Particulate matter; Small for gestational age ID INTRAUTERINE GROWTH RESTRICTION; FETAL-GROWTH; PARTICULATE MATTER; MATERNAL EXPOSURE; CALIFORNIA; PREGNANCY; OUTCOMES; RISK; POLLUTANTS; AUSTRALIA AB A range of health effects, including adverse pregnancy outcomes, have been associated with exposure to ambient concentrations of particulate matter (PM) and ozone (O-3). The objective of this study was to determine whether maternal exposure to fine particulate matter (PM2.5) and O-3 during pregnancy is associated with the risk of term low birthweight and small for gestational age infants in both single and co-pollutant models. Term low birthweight and small for gestational age were determined using all birth certificates from North Carolina from 2003 to 2005. Ambient air concentrations of PM2.5 and O-3 were predicted using a hierarchical Bayesian model of air pollution that combined modeled air pollution estimates from the EPA's Community Multi-Scale Air Quality (CMAQ) model with air monitor data measured by the EPA's Air Quality System. Binomial regression, adjusted for multiple potential confounders, was performed. In adjusted single-pollutant models for the third trimester, O-3 concentration was positively associated with small for gestational age and term low birthweight births [risk ratios for an interquartile range increase in O-3: 1.16 (95% CI 1.11, 1.22) for small for gestational age and 2.03 (95% CI 1.80, 2.30) for term low birthweight]; however, inverse or null associations were observed for PM2.5 [risk ratios for an interquartile range increase in PM2.5: 0.97 (95% CI 0.95, 0.99) for small for gestational age and 1.01 (95% CI 0.97, 1.06) for term low birthweight]. Findings were similar in co-pollutant models and linear models of birthweight. These results suggest that O-3 concentrations in both urban and rural areas may be associated with an increased risk of term low birthweight and small for gestational age births. Published by Elsevier Inc. C1 [Vinikoor-Imler, Lisa C.; Davis, J. Allen; Luben, Thomas J.] US EPA, NCEA, Res Triangle Pk, NC 27711 USA. [Meyer, Robert E.] State Ctr Hlth Stat, North Carolina Birth Defects Monitoring Program, Raleigh, NC 27599 USA. [Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community Hlth, Portland, OR 97207 USA. RP Vinikoor-Imler, LC (reprint author), US EPA, NCEA, 109 TW Alexander Dr,Attn MD B243-01, Res Triangle Pk, NC 27711 USA. EM vinikoor-imler.lisa@epa.gov NR 37 TC 10 Z9 12 U1 1 U2 19 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD JUL PY 2014 VL 132 BP 132 EP 139 DI 10.1016/j.envres.2014.03.040 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AJ7FJ UT WOS:000337862300020 PM 24769562 ER PT J AU Antonelli, R Shao, K Thomas, DJ Sams, R Cowden, J AF Antonelli, Ray Shao, Kan Thomas, David J. Sams, Reeder, II Cowden, John TI AS3MT, GSTO, and PNP polymorphisms: Impact on arsenic methylation and implications for disease susceptibility SO ENVIRONMENTAL RESEARCH LA English DT Review DE Arsenic; Arsenic methyltransferase; Purine nucleoside phosphorylase; Glutathione-s-transferase omega; Genetic polymorphisms ID PURINE NUCLEOSIDE PHOSPHORYLASE; BLADDER-CANCER MORTALITY; TRANSFERASE OMEGA GENE; WATER-SUPPLY-SYSTEM; DRINKING-WATER; SKIN-CANCER; SOUTHWESTERN TAIWAN; UROTHELIAL CARCINOMA; ENDEMIC AREA; MONOMETHYLARSONIC ACID AB Background: Oral exposure to inorganic arsenic (iAs) is associated with adverse health effects. Epidemiological studies suggest differences in susceptibility to these health effects, possibly due to genotypic variation. Genetic polymorphisms in iAs metabolism could lead to increased susceptibility by altering urinary iAs metabolite concentrations. Objective: To examine the impact of genotypic polymorphisms on iAs metabolism. Methods: We screened 360 publications from PubMed and Web of Science for data on urinary mono- and dimethylated arsenic (MMA and DMA) percentages and polymorphic genes encoding proteins that are hypothesized to play roles in arsenic metabolism. The genes we examined were arsenic (+3) methyltransferase (AS3MT), glutathione-s-transferase omega (GSTO), and purine nucleoside phosphoulase (PNP). Relevant data were pooled to determine which polymorphisms are associated across studies with changes in urinary metabolite concentration. Results: In our review, AS3MT polymorphisms rs3740390, rs11191439, and rs11191453 were associated with statistically significant changes in percent urinary MMA. Studies of GSTO polymorphisms did not indicate statistically significant associations with methylation, and there are insufficient data on PNP polymorphisms to evaluate their impact on metabolism. Discussion: Collectively, these data support the hypothesis that AS3MT polymorphisms alter in vivo metabolite concentrations. Preliminary evidence suggests that AS3MT genetic polymorphisms may impact disease susceptibility GSTO polymorphisms were not associated with iAs-associated health outcomes. Additional data are needed to evaluate the association between PNP polymorphisms and iAs-associated health outcomes. Delineation of these relationships may inform iAs mode(s) of action and the approach for evaluating low-dose health effects for iAs. Conclusions: Genotype impacts urinary iAs metabolite concentrations and may be a potential mechanism for iAs-related disease susceptibility. Published by Elsevier Inc. C1 [Antonelli, Ray; Shao, Kan] US EPA, ORISE Fellow, Hazardous Pollutant Assessment Grp, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Thomas, David J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Res Lab, Res Triangle Pk, NC 27711 USA. [Sams, Reeder, II; Cowden, John] US EPA, Hazardous Pollutant Assessment Grp, Natl Ctr Environm Assessment, Res Triangle Pk Div, Res Triangle Pk, NC 27711 USA. RP Cowden, J (reprint author), US EPA, Natl Ctr Environm Assessment, B243-01, Res Triangle Pk, NC 27711 USA. EM cowden.john@epa.gov RI Shao, Kan/B-8242-2015 OI Shao, Kan/0000-0002-5512-2377 FU Research Participation Program for the U.S. Environmental Protection Agency; Office of Research and Development; Oak Ridge Institute for Science and Education through the U.S. Department of Energy FX This research was supported in part by an appointment to the Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 96 TC 16 Z9 16 U1 2 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD JUL PY 2014 VL 132 BP 156 EP 167 DI 10.1016/j.envres.2014.03.012 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AJ7FJ UT WOS:000337862300023 PM 24792412 ER PT J AU Li, SB Wallis, LK Diamond, SA Ma, HB Hoff, DJ AF Li, Shibin Wallis, Lindsay K. Diamond, Stephen A. Ma, Hongbo Hoff, Dale J. TI SPECIES SENSITIVITY AND DEPENDENCE ON EXPOSURE CONDITIONS IMPACTING THE PHOTOTOXICITY OF TiO2 NANOPARTICLES TO BENTHIC ORGANISMS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nano-TiO2; Phototoxicity; Benthic organisms; Species sensitivity; Exposure scenario ID TITANIUM-DIOXIDE NANOPARTICLES; AQUATIC ENVIRONMENT; CARBON NANOTUBES; MARINE ORGANISMS; TOXICITY; NANOMATERIALS; RADIATION; AMPHIPOD; BEHAVIOR AB Toxicity of titanium dioxide nanoparticles (nano-TiO2) to aquatic organisms can be greatly increased after exposure to ultraviolet (UV) radiation. This phenomenon has received some attention for water column species; however, investigations of nano-TiO2 phototoxicity for benthic organisms are still limited. In the present study, bioassays of 3 representative benthic organisms (Hyalella azteca, Lumbriculus variegatus, and Chironomus dilutus) were conducted to evaluate nano-TiO2 phototoxicity. When exposed to 20 mg/L of nano-TiO2 and various light intensities (0-30 W/m(2)), H. azteca was the most sensitive, with a median lethal dose of 40.7 (95% confidence interval, 36.3-44.7) Wh/m(2), and hence is a potential model organism in future toxicological guidelines for photoactive nanomaterials to freshwater benthos. Without the presence of nano-TiO2, no mortality was observed in L. variegatus and C. dilutus exposed to UV intensity ranging from 0W/m(2) to 41 W/m(2). However, a sharp drop of H. azteca survival was observed when UV intensity was higher than 9.4 W/m(2), demonstrating the importance of UV-only effects on the ultimate phototoxicity of nanomaterials. Furthermore, both bioavailability and surface attachment of nano-TiO2 onto organisms were affected by the exposure scenario, supported by the exposure scenario-dependent phototoxicity seen in H. azteca and C. dilutus. Overall, the present study demonstrates the importance of species sensitivity and exposure scenarios in future test guidelines of nano-phototoxicity. (C) 2014 SETAC C1 [Li, Shibin; Wallis, Lindsay K.; Ma, Hongbo; Hoff, Dale J.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Diamond, Stephen A.] Nanosafe, Blacksburg, VA USA. RP Li, SB (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM li.shibin@epa.gov FU National Research Council Research Associateship Award at the US Environmental Protection Agency, Mid-Continent Ecology Division Laboratory FX The present study was performed while one of the authors, S. Li, held a National Research Council Research Associateship Award at the US Environmental Protection Agency, Mid-Continent Ecology Division Laboratory. NR 28 TC 13 Z9 13 U1 3 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2014 VL 33 IS 7 BP 1563 EP 1569 DI 10.1002/etc.2583 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AJ6FD UT WOS:000337784500018 PM 24846372 ER PT J AU Kahl, MD Villeneuve, DL Stevens, K Schroeder, A Makynen, EA LaLone, CA Jensen, KM Hughes, M Holmen, BA Eid, E Durhan, EJ Cavallin, JE Berninger, J Ankley, GT AF Kahl, Michael D. Villeneuve, Daniel L. Stevens, Kyle Schroeder, Anthony Makynen, Elizabeth A. LaLone, Carlie A. Jensen, Kathleen M. Hughes, Meagan Holmen, Bruce A. Eid, Evan Durhan, Elizabeth J. Cavallin, Jenna E. Berninger, Jason Ankley, Gerald T. TI AN INEXPENSIVE, TEMPORALLY INTEGRATED SYSTEM FOR MONITORING OCCURRENCE AND BIOLOGICAL EFFECTS OF AQUATIC CONTAMINANTS IN THE FIELD SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Contaminant mixtures; Aquatic systems; Monitoring; Toxicity; Methods ID MINNOWS PIMEPHALES-PROMELAS; FATHEAD MINNOWS; IN-SITU; EXPOSURE; FISH; EXPRESSION; WATER; RIVER; KETOCONAZOLE; METABOLITES AB Assessment of potential risks of complex contaminant mixtures in the environment requires integrated chemical and biological approaches. In support of the US Great Lakes Restoration Initiative, the US Environmental Protection Agency lab in Duluth, MN, is developing these types of methods for assessing possible risks of aquatic contaminants in near-shore Great Lakes (USA) sites. One component involves an exposure system for caged fathead minnow (Pimephales promelas) adults suitable for the wide range of habitat and deployment situations encountered in and around the Great Lakes. To complement the fish exposure system, the authors developed an automated device for collection of composite water samples that could be simultaneously deployed with the cages and reflect a temporally integrated exposure of the animals. The present study describes methodological details of the design, construction, and deployment of a flexible yet comparatively inexpensive (<600 USD) caged-fish/autosampler system. The utility and performance of the system were demonstrated with data collected from deployments at several Great Lakes sites. For example, over 3 field seasons, only 2 of 130 deployed cages were lost, and approximately 99% of successfully deployed adult fish were recovered after exposures of 4 d or longer. A number of molecular, biochemical, and apical endpoints were successfully measured in recovered animals, changes in which reflected known characteristics of the study sites (e. g., upregulation of hepatic genes involved in xenobiotic metabolism in fish held in the vicinity of wastewater treatment plants). The automated composite samplers proved robust with regard to successful water collection (>95% of deployed units in the latest field season), and low within-and among-unit variations were found relative to programmed collection volumes. Overall, the test system has excellent potential for integrated chemical-biological monitoring of contaminants in a variety of field settings. (C) 2014 SETAC C1 [Kahl, Michael D.; Villeneuve, Daniel L.; Makynen, Elizabeth A.; LaLone, Carlie A.; Jensen, Kathleen M.; Hughes, Meagan; Eid, Evan; Durhan, Elizabeth J.; Ankley, Gerald T.] US EPA, Duluth, MN 55804 USA. [Stevens, Kyle; Cavallin, Jenna E.] Oak Ridge Inst Sci & Educ ORISE Program, Duluth, MN USA. [Schroeder, Anthony] Univ Minnesota, Duluth, MN 55812 USA. [Berninger, Jason] CNR, Duluth, MN USA. RP Ankley, GT (reprint author), US EPA, Duluth, MN 55804 USA. EM ankley.gerald@epa.gov RI Berninger, Jason/O-2401-2016 OI Berninger, Jason/0000-0003-3045-7899 NR 34 TC 7 Z9 7 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2014 VL 33 IS 7 BP 1584 EP 1595 DI 10.1002/etc.2591 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AJ6FD UT WOS:000337784500021 PM 24668901 ER PT J AU Pinto, PX Al-Abed, SR Holder, C Reisman, DJ AF Pinto, Patricio X. Al-Abed, Souhail R. Holder, Christopher Reisman, David J. TI Evaluation of metal partitioning and mobility in a sulfidic mine tailing pile under oxic and anoxic conditions SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Metal mobilization; Mn; Zn; Mine tailings leaching; Mine waste ID X-RAY PHOTOELECTRON; CONTAMINATED SOILS; TRACE-ELEMENTS; SEDIMENTS; ZINC; XPS; SPECTROSCOPY; SURFACE; DISSOLUTION; SPECIATION AB Mining-influenced water emanating from mine tailings and potentially contaminating surface water and groundwater is one of the most important environmental issues linked to the mining industry. In this study, two subsets of Callahan Mine tailings (mainly comprised of silicates, sulfides, and carbonates) were collected using sealed containers, which allowed keeping the samples under anoxic conditions during transportation and storage. Among the potential contaminants, in spite of high concentrations of Cu, Mn, Pb, and Zn present in the solid mine tailings, only small amounts of Mn and Zn were found in the overlying pore water. The samples were subjected to leaching tests at different reduction-oxidation (redox) conditions to compare metal and S mobilization under oxic and anoxic conditions. It was observed that Cd, Cu, Mn, Pb, S, and Zn were mobilized at higher rates under oxic conditions, while Fe was mobilized at a higher rate under anoxic conditions in comparable constant pH experiments. These results suggest that metal mobilization is significantly impacted by redox conditions. When anoxic metal mobilization assessment is required, it is recommended to always maintain anoxic conditions because oxygen exposure may affect metal mobilization. A sequential extraction performed under oxic conditions revealed that most of the metals in the samples were associated with the sulfidic fraction and that the labile fraction was associated with Mn and moderate amounts of Pb and Zn. Published by Elsevier Ltd. C1 [Pinto, Patricio X.; Holder, Christopher] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Reisman, David J.] CDM Smith, Cincinnati, OH 45249 USA. [Reisman, David J.] US EPA, Natl Risk Management Res Lab, ORD Engn Tech Support Ctr, Cincinnati, OH 45249 USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov OI Pinto, Patricio/0000-0002-7840-457X FU U.S. EPA National Risk Management Research Laboratory, Cincinnati, Ohio FX This research was funded and performed by the U.S. EPA National Risk Management Research Laboratory, Cincinnati, Ohio. This paper has not been subjected to the Agency's internal review; therefore, the research results presented herein do not necessarily reflect the views of the Agency or its policy. Mention of trade names and commercial products does not constitute endorsement or recommendation for use. The authors thank Dr. Jurate Virkutite and Dr. Tammie Gerke for their assistance with solid results analysis and interpretation and Mr. Anthony Morris for laboratory work. We appreciate the support and granted site access of Mr. Ed Hathaway, the U.S EPA Region 1 Remedial Project Manager for the Callahan Mine, who has been a long and strong supporter of EPA ORD mining research. NR 36 TC 2 Z9 2 U1 0 U2 22 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD JUL 1 PY 2014 VL 140 BP 135 EP 144 DI 10.1016/j.jenvman.2014.03.004 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA AJ7KU UT WOS:000337876400015 PM 24747936 ER PT J AU Elmore, SA Ryan, AM Wood, CE Crabbs, TA Sills, RC AF Elmore, Susan A. Ryan, Anne M. Wood, Charles E. Crabbs, Torrie A. Sills, Robert C. TI FutureTox II: Contemporary Concepts in Toxicology: "Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology" SO TOXICOLOGIC PATHOLOGY LA English DT Article C1 [Elmore, Susan A.; Sills, Robert C.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Ryan, Anne M.] Pfizer Inc, Pfizer Global R&D, Groton, CT 06340 USA. [Wood, Charles E.] US EPA, Res Triangle Pk, NC 27711 USA. [Crabbs, Torrie A.] Expt Pathol Labs Inc, Res Triangle Pk, NC USA. RP Elmore, SA (reprint author), NIEHS, Natl Toxicol Program, 111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM elmore@niehs.nih.gov FU National Institutes of Health (NIH); National Institute of Environmental Health Sciences (NIEHS) FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported (in part) by the National Institutes of Health (NIH) and National Institute of Environmental Health Sciences (NIEHS). NR 5 TC 0 Z9 1 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-6233 EI 1533-1601 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD JUL PY 2014 VL 42 IS 5 BP 940 EP 942 DI 10.1177/0192623314537135 PG 3 WC Pathology; Toxicology SC Pathology; Toxicology GA AJ9GX UT WOS:000338017200017 PM 24855144 ER PT J AU Judson, R Houck, K Martin, M Knudsen, T Thomas, RS Sipes, N Shah, I Wambaugh, J Crofton, K AF Judson, Richard Houck, Keith Martin, Matt Knudsen, Thomas Thomas, Russell S. Sipes, Nisha Shah, Imran Wambaugh, John Crofton, Kevin TI In Vitro and Modelling Approaches to Risk Assessment from the US Environmental Protection Agency ToxCast Programme SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY LA English DT Review ID COMPUTATIONAL TOXICOLOGY RESOURCE; THROUGHPUT SCREENING DATA; REPRODUCTIVE TOXICITY; DEVELOPMENTAL TOXICITY; CONCEPTUAL-FRAMEWORK; VASCULAR DEVELOPMENT; PREDICTIVE MODELS; VIVO HAZARD; CHEMICALS; EXPOSURE AB A significant challenge in toxicology is the too many chemicals' problem. Human beings and environmental species are exposed to tens of thousands of chemicals, only a small percentage of which have been tested thoroughly using standard in vivo test methods. This study reviews several approaches that are being developed to deal with this problem by the U.S. Environmental Protection Agency, under the umbrella of the ToxCast programme (http://epa.gov/ncct/toxcast/). The overall approach is broken into seven tasks: (i) identifying biological pathways that, when perturbed, can lead to toxicity; (ii) developing high-throughput in vitro assays to test chemical perturbations of these pathways; (iii) identifying the universe of chemicals with likely human or ecological exposure; (iv) testing as many of these chemicals as possible in the relevant in vitro assays; (v) developing hazard models that take the results of these tests and identify chemicals as being potential toxicants; (vi) generating toxicokinetics data on these chemicals to predict the doses at which these hazard pathways would be activated; and (vii) developing exposure models to identify chemicals for which these hazardous dose levels could be achieved. This overall strategy is described and briefly illustrated with recent examples from the ToxCast programme. C1 [Judson, Richard; Houck, Keith; Martin, Matt; Knudsen, Thomas; Thomas, Russell S.; Sipes, Nisha; Shah, Imran; Wambaugh, John; Crofton, Kevin] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Judson, R (reprint author), US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. EM judson.richard@epa.gov RI Crofton, Kevin/J-4798-2015; OI Crofton, Kevin/0000-0003-1749-9971; Thomas, Russell/0000-0002-2340-0301; Judson, Richard/0000-0002-2348-9633; Wambaugh, John/0000-0002-4024-534X NR 53 TC 31 Z9 32 U1 7 U2 57 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1742-7835 EI 1742-7843 J9 BASIC CLIN PHARMACOL JI Basic Clin. Pharmacol. Toxicol. PD JUL PY 2014 VL 115 IS 1 BP 69 EP 76 DI 10.1111/bcpt.12239 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AJ3QY UT WOS:000337583400010 PM 24684691 ER PT J AU Dabrowski, J Hall, G Lubcker, N Oberholster, PJ Phillips, DL Woodborne, S AF Dabrowski, J. Hall, G. Luebcker, N. Oberholster, P. J. Phillips, D. L. Woodborne, S. TI Piscivory does not cause pansteatitis (yellow fat disease) in Oreochromis mossambicus from an African subtropical reservoir SO FRESHWATER BIOLOGY LA English DT Article DE food webs; Olifants River; Oreochromis mossambicus; pansteatitis; stable isotopes ID CLARIAS-GARIEPINUS BURCHELL; KRUGER-NATIONAL-PARK; SOUTH-AFRICA; OLIFANTS RIVER; CROCODILE POPULATION; SHARPTOOTH CATFISH; STABLE-ISOTOPES; LAKE LOSKOP; STEATITIS; TILAPIA AB Pansteatitis (yellow fat disease) is ubiquitous in the free-ranging population of Oreochromis mossambicus from Loskop Reservoir (LR), South Africa. The disease is nutritionally mediated and associated with a diet high in polyunsaturated or rancid fats, frequently of fish origin. While piscivory has never been reported in dietary studies of O.mossambicus in their native range, their opportunistic and omnivorous feeding habits mean that piscivory cannot be ruled out as a cause of the disease. The diet of O.mossambicus from LR (n=91) was compared with a population from Flag Boshielo Reservoir (FBR; n=81) located <100km downstream, where no pansteatitis occurs. The stomach contents and stable isotope signatures (15N and 13C) of fish and food sources were evaluated across four seasons. Isotope signatures were also compared over various time scales from historic samples and mortalities collected from LR. There was no evidence of piscivorous feeding behaviour in fish from either location or from historic LR samples. The results of the stable isotope analysis in R mixing model and stomach contents analysis showed that the dinoflagellate, Ceratium hirundinella, was the dominant food source followed by zooplankton, detritus and Microcystis aeruginosa in LR. The diet of fish from FBR was less diverse than fish from LR and was dominated by sediment and detritus. The distinguishing feature of the dietary comparison between reservoirs was the abundance of planktonic food items dominated by C.hirundinella in the diet of fish from LR. The lack of evidence for piscivory among O.mossambicus from LR suggests that the classic aetiology of pansteatitis does not apply. This highlights the need to further explore direct (environmental exposure to pollutants) and indirect (dietary exposure) links to pansteatitis. This study identified the major dietary constituents for O.mossambicus, which enables future research to focus on their nutritional and chemical composition. C1 [Dabrowski, J.; Oberholster, P. J.] Univ Pretoria, Fac Vet Sci, Dept Paraclin Sci, ZA-0110 Onderstepoort, South Africa. [Dabrowski, J.] CSIR, ZA-0001 Pretoria, South Africa. [Hall, G.] Univ Pretoria, Mammal Res Inst, Stable Isotope Lab, Dept Zool & Entomol, ZA-0002 Pretoria, South Africa. [Luebcker, N.] Univ Pretoria, Dept Zool & Entomol, ZA-0002 Pretoria, South Africa. [Oberholster, P. J.] CSIR, Stellenbosch, South Africa. [Phillips, D. L.] Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR USA. [Woodborne, S.] IThemba Labs, Johannesburg, South Africa. RP Dabrowski, J (reprint author), CSIR, ZA-0001 Pretoria, South Africa. EM jdabrowski1@csir.co.za RI Hall, Grant/J-9886-2016 OI Hall, Grant/0000-0002-2164-4900 FU National Research Foundation (NRF) FX The financial assistance of the National Research Foundation (NRF) towards this research is hereby acknowledged. Opinions expressed and conclusions arrived at, are those of the authors and are not necessarily to be attributed to the NRF. D. L. Phillips' time has been provided by the U.S. Environmental Protection Agency. The manuscript has been subjected to the Agency's peer and administrative review, and approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Thanks to the Olifants River Forum for providing funding for this research. Fieldwork and helpful discussions with J.M. Dabrowski, A. Hoffman and T. A. Zengeya are sincerely appreciated. J.G. Myburgh is thanked for providing historic fish samples. NR 52 TC 6 Z9 6 U1 0 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0046-5070 EI 1365-2427 J9 FRESHWATER BIOL JI Freshw. Biol. PD JUL PY 2014 VL 59 IS 7 BP 1484 EP 1496 DI 10.1111/fwb.12360 PG 13 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA AJ2XP UT WOS:000337528600011 ER PT J AU Craig, EA Wang, NC Zhao, QJ AF Craig, Evisabel A. Wang, Nina Ching Zhao, Q. Jay TI Using quantitative structure-activity relationship modeling to quantitatively predict the developmental toxicity of halogenated azole compounds SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE QSAR; developmental toxicity; halogenated compounds; azoles ID VALIDATION; ACCEPTANCE; RISK AB Developmental toxicity is a relevant endpoint for the comprehensive assessment of human health risk from chemical exposure. However, animal developmental toxicity data remain unavailable for many environmental contaminants due to the complexity and cost of these types of analyses. Here we describe an approach that uses quantitative structure-activity relationship modeling as an alternative methodology to fill data gaps in the developmental toxicity profile of certain halogenated compounds. Chemical information was obtained and curated using the OECD Quantitative Structure-Activity Relationship Toolbox, version 3.0. Data from 35 curated compounds were analyzed via linear regression to build the predictive model, which has an R2 of 0.79 and a Q2 of 0.77. The applicability domain (AD) was defined by chemical category and structural similarity. Seven halogenated chemicals that fit the AD but are not part of the training set were employed for external validation purposes. Our model predicted lowest observed adverse effect level values with a maximal threefold deviation from the observed experimental values for all chemicals that fit the AD. The good predictability of our model suggests that this method may be applicable to the analysis of qualifying compounds whenever developmental toxicity information is lacking or incomplete for risk assessment considerations. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Craig, Evisabel A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Craig, Evisabel A.; Wang, Nina Ching; Zhao, Q. Jay] US EPA, Natl Ctr Environm Assessment, Off Res Dev, Cincinnati, OH 45268 USA. RP Zhao, QJ (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res Dev, Cincinnati, OH 45268 USA. EM zhao.jay@epa.gov FU U.S. Department of Energy; EPA FX The authors wish to thank Drs. Scott Wesselkamper and Dan Petersen for their critical review of this manuscript. The views expressed in this report are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement. This study was supported in part by the research participation program administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 21 TC 0 Z9 0 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL PY 2014 VL 34 IS 7 BP 787 EP 794 DI 10.1002/jat.2940 PG 8 WC Toxicology SC Toxicology GA AJ3PJ UT WOS:000337578900006 PM 24122872 ER PT J AU Hammond, D Croghan, C Shin, H Burnett, R Bard, R Brook, RD Williams, R AF Hammond, Davyda Croghan, Carry Shin, Hwashin Burnett, Richard Bard, Robert Brook, Robert D. Williams, Ron TI Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE DEARS; exposure factors; cardiovascular health outcomes ID PARTICULATE MATTER PANEL; NITROGEN-DIOXIDE; AIR-POLLUTION; CENTRAL SITE; DETROIT; INDOOR; PARTICLES; MICHIGAN; OUTDOOR; HEALTH AB The US Environmental Protection Agency's (US EPA) Detroit Exposure and Aerosol Research Study (DEARS) has provided extensive data on human exposures to a wide variety of air pollutants and their impact on human health. Previous analyses in the DEARS revealed select cardiovascular (CV) health outcomes such as increase in heart rate (HR) associated with hourly based continuous personal fine particulate matter (PM2.5) exposures in this adult, non-smoking cohort. Examination of time activity diary (TAD), follow-up questionnaire (FQ) and the continuous PM2.5 personal monitoring data provided the means to more fully examine the impact of discreet human activity patterns on personal PM2.5 exposures and changes in CV outcomes. A total of 329 343 min-based PM2.5 personal measurements involving 50 participants indicated that 75% of these total events resulted in exposures <35 mu g/m(3). Cooking and car-related events accounted for nearly 10% of the hourly activities that were identified with observed peaks in personal PM2.5 exposures. In-residence cooking often resulted in some of the highest incidents of 1 min exposures (33.5-17.6,mu g/m(3)), with average peaks for such events in excess of 209,mu g/m(3). PM2.5 exposure data from hourly based personal exposure activities (for example cooking, cleaning and household products) were compared with daily CV data from the DEARS subject population. A total of 1300 hourly based lag risk estimates associated with changes in brachial artery diameter and flow-mediated dilatation (BAD and FMD, respectively), among others, were defined for this cohort. Findings indicate that environmental tobacco smoke (ETS) exposures resulted in significant HR changes between 3 and 7h following the event, and exposure to smells resulted in increases in BAD on the order of 0.2-0.7 mm/mu g/m(3). Results demonstrate that personal exposures may be associated with several biological responses, sometimes varying in degree and direction in relation to the extent of the exposure. C1 [Hammond, Davyda; Croghan, Carry; Williams, Ron] US EPA, Res Triangle Pk, NC 27711 USA. [Shin, Hwashin; Burnett, Richard] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada. [Bard, Robert; Brook, Robert D.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA. RP Williams, R (reprint author), US EPA, MD E-205-04, Res Triangle Pk, NC 27711 USA. EM williams.ronald@epa.gov FU US Environmental Protection Agency through its Office of Research and Development FX The US Environmental Protection Agency through its Office of Research and Development funded and conducted the research described here under contract 68-D-00-012 (RTI International), EP-D-04-068 (Battelle Columbus Laboratory), 68-D-00-206 and EP-05-D-065 (Alion Science and Technology). It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use. The US EPA acknowledges the staffs of Alion Science and Technology for preparation of sampling media and RTI International for overseeing field data collections. We thank the DEARS cohort for their participation. NR 41 TC 2 Z9 3 U1 3 U2 28 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JUL-AUG PY 2014 VL 24 IS 4 BP 337 EP 345 DI 10.1038/jes.2013.46 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ4MZ UT WOS:000337651800001 PM 23982121 ER PT J AU Breen, MS Long, TC Schultz, BD Crooks, J Breen, M Langstaff, JE Isaacs, KK Tan, YM Williams, RW Cao, Y Geller, AM Devlin, RB Batterman, SA Buckley, TJ AF Breen, Michael S. Long, Thomas C. Schultz, Bradley D. Crooks, James Breen, Miyuki Langstaff, John E. Isaacs, Kristin K. Tan, Yu-Mei Williams, Ronald W. Cao, Ye Geller, Andrew M. Devlin, Robert B. Batterman, Stuart A. Buckley, Timothy J. TI GPS-based microenvironment tracker (MicroTrac) model to estimate time location of individuals for air pollution exposure assessments: Model evaluation in central North Carolina SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE GPS; time-activity; microenvironment; air pollution; health ID POSITIONING SYSTEM GPS; PARTICULATE MATTER; CLASSIFICATION; PERFORMANCE; POLLUTANTS; CHILDRENS; INDOOR AB A critical aspect of air pollution exposure assessment is the estimation of the time spent by individuals in various microenvironments (ME). Accounting for the time spent in different ME with different pollutant concentrations can reduce exposure misclassifications, while failure to do so can add uncertainty and bias to risk estimates. In this study, a classification model, called MicroTrac, was developed to estimate time of day and duration spent in eight ME (indoors and outdoors at home, work, school; inside vehicles; other locations) from global positioning system (GPS) data and geocoded building boundaries. Based on a panel study, MicroTrac estimates were compared with 24-h diary data from nine participants, with corresponding GPS data and building boundaries of home, school, and work. MicroTrac correctly classified the ME for 99.5% of the daily time spent by the participants. The capability of MicroTrac could help to reduce the time location uncertainty in air pollution exposure models and exposure metrics for individuals in health studies. C1 [Breen, Michael S.; Schultz, Bradley D.; Isaacs, Kristin K.; Tan, Yu-Mei; Williams, Ronald W.; Buckley, Timothy J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Long, Thomas C.; Cao, Ye] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27709 USA. [Crooks, James; Breen, Miyuki; Devlin, Robert B.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. [Langstaff, John E.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27709 USA. [Geller, Andrew M.] US EPA, Immediate Off Assistant Administrator, Res Triangle Pk, NC 27709 USA. [Batterman, Stuart A.] Univ Michigan, Ann Arbor, MI 48109 USA. RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA. EM Breen.Michael@epa.gov FU North Carolina State University/Environmental Protection Agency Cooperative Training Program in Environmental Sciences Research, Training [CT833235-01-0]; Oak Ridge Institute for Science and Education (ORISE)/Environmental Protection Agency Research Participation Training Program [DW-89-92298301-0] FX We thank Jennifer Richmond-Bryant and Karen Wesson for review comments and helpful suggestions. MB was supported by the North Carolina State University/Environmental Protection Agency Cooperative Training Program in Environmental Sciences Research, Training Agreement CT833235-01-0 with North Carolina State University. YC was supported by the Oak Ridge Institute for Science and Education (ORISE)/Environmental Protection Agency Research Participation Training Program (Interagency Agreement DW-89-92298301-0). Procedures involving humans were conducted in accordance with US EPA Order 1000.17 Change Al (Policy and Procedures on Protection of Human Research Subjects). These procedures were reviewed and approved by the US EPA Human Subjects Research Review Official Although this manuscript was reviewed by the US Environmental Protection Agency and approved for publication, it may not necessarily reflect official Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 28 TC 10 Z9 10 U1 0 U2 16 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JUL-AUG PY 2014 VL 24 IS 4 BP 412 EP 420 DI 10.1038/jes.2014.13 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ4MZ UT WOS:000337651800010 PM 24619294 ER PT J AU Soto-Centeno, JA Phillips, DL Kurta, A Hobson, KA AF Soto-Centeno, J. Angel Phillips, Donald L. Kurta, Allen Hobson, Keith A. TI Food resource partitioning in syntopic nectarivorous bats on Puerto Rico SO JOURNAL OF TROPICAL ECOLOGY LA English DT Article DE Carbon-13; Erophylla bombifrons; frugivory; insectivory; Monophyllus redmani; nectarivory; nitrogen-15; stable isotope ID STABLE-ISOTOPE ANALYSIS; MIXING MODELS; CAROLLIA-PERSPICILLATA; EPTESICUS-FUSCUS; MILK-COMPOSITION; CARBON ISOTOPES; RAIN-FOREST; FRUIT BATS; NITROGEN; PHYLLOSTOMIDAE AB Understanding the dietary needs of syntopic species is essential for examining species coexistence and resource partitioning. We analysed stable isotopes of carbon (delta C-13) and nitrogen (delta N-15) to estimate the diet of two putative nectarivorous bats on Puerto Rico, the brown flower bat (Erophylla bombifrons) and the Greater Antillean long-tongued bat (Monophyllus redmani). Isotopic ratios of delta C-13 and delta N-15 were obtained from whole blood of both species of bat and tissues of available plant foods and insect prey over 15 wk at the same locality. We used a concentration-dependent Bayesian mixing model to determine probability distributions of feasible dietary contributions for major potential foods used by each species of bat. Additionally, separate dietary estimates were conducted for males and non-reproductive, pregnant and lactating females to determine differences due to reproductive condition. Insects were an important source of protein for M. redmani, whereas E. bombifrons obtained most of its protein from plants. In both species of bat, lactating females had lower assimilated nitrogen than males, suggesting more reliance on plants for protein. We observed no intraspecific differences in assimilated carbon among reproductive conditions. Flight and lactation are energetically expensive and may explain the increased consumption of high-energy foods, such as fruit or nectar, in lactating female bats. Comparison of isotopes between E. bombifrons and M. redmani illustrate the differential use of food resources by these insular syntopic species of bat. C1 [Soto-Centeno, J. Angel] Amer Museum Nat Hist, Div Mammal, New York, NY 10024 USA. [Soto-Centeno, J. Angel; Kurta, Allen] Eastern Michigan Univ, Dept Biol, Ypsilanti, MI 48197 USA. [Phillips, Donald L.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Hobson, Keith A.] Environm Canada, Saskatoon, SK S7N 3H5, Canada. RP Soto-Centeno, JA (reprint author), Amer Museum Nat Hist, Div Mammal, New York, NY 10024 USA. EM asoto-centeno@amnh.org FU Meta Hellwig Graduate Research Award; Graduate School, Eastern Michigan University FX We thank A. Rodriguez-Duran, for facilitating access to Mata de Platano, and B. Rivera-Marchand, for assisting with fieldwork. H. A. York, L. G. Herrera M. and C. C. Voigt provided constructive comments on early versions of this manuscript. Funding was provided by a Meta Hellwig Graduate Research Award to JASC and a Research Support Award to AK from the Graduate School, Eastern Michigan University. JASC thanks R. D. Barrilito for additional support. This paper has been subjected to peer and administrative review of the Environmental Protection Agency (EPA) and approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 63 TC 0 Z9 0 U1 3 U2 26 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0266-4674 EI 1469-7831 J9 J TROP ECOL JI J. Trop. Ecol. PD JUL PY 2014 VL 30 BP 359 EP 369 DI 10.1017/S0266467414000145 PN 4 PG 11 WC Ecology SC Environmental Sciences & Ecology GA AJ5XH UT WOS:000337763100008 ER PT J AU McMurray, RG Soares, J Caspersen, CJ McCurdy, T AF McMurray, Robert G. Soares, Jesus Caspersen, Carl J. McCurdy, Thomas TI Examining Variations of Resting Metabolic Rate of Adults: A Public Health Perspective SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE KILOCALORIES; OXYGEN UPTAKE; META-ANALYSIS; BODY MASS INDEX; SEXES; AGE ID BODY-FAT DISTRIBUTION; BROWN ADIPOSE-TISSUE; ENERGY-EXPENDITURE; PHYSICAL-ACTIVITIES; OXYGEN-CONSUMPTION; OBESE WOMEN; AGE; MEN; METAANALYSIS; EXERCISE AB Purpose: There has not been a recent comprehensive effort to examine existing studies on the resting metabolic rate (RMR) of adults to identify the effect of common population demographic and anthropometric characteristics. Thus, we reviewed the literature on RMR (kcal.kg(-1).h(-1)) to determine the relationship of age, sex, and obesity status to RMR as compared with the commonly accepted value for the metabolic equivalent (MET; e. g., 1.0 kcal.kg(-1).h(-1)). Methods: Using several databases, scientific articles published from 1980 to 2011 were identified that measured RMR, and from those, others dating back to 1920 were identified. One hundred and ninety-seven studies were identified, resulting in 397 publication estimates of RMR that could represent a population subgroup. Inverse variance weighting technique was applied to compute means and 95% confidence intervals (CI). Results: The mean value for RMR was 0.863 kcal.kg(-1).h(-1) (95% CI = 0.852-0.874), higher for men than women, decreasing with increasing age, and less in overweight than normal weight adults. Regardless of sex, adults with BMI >= 30 kg.m(-2) had the lowest RMR (<0.741 kcal.kg(-1).h(-1)). Conclusions: No single value for RMR is appropriate for all adults. Adhering to the nearly universally accepted MET convention may lead to the overestimation of the RMR of approximately 10% for men and almost 15% for women and be as high as 20%-30% for some demographic and anthropometric combinations. These large errors raise questions about the longstanding adherence to the conventional MET value for RMR. Failure to recognize this discrepancy may result in important miscalculations of energy expended from interventions using physical activity for diabetes and other chronic disease prevention efforts. C1 [McMurray, Robert G.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Soares, Jesus; Caspersen, Carl J.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [McCurdy, Thomas] US Environm Protect Agcy EPA, Res Triangle Pk, NC USA. RP McMurray, RG (reprint author), Univ N Carolina, CB 8700,Fetzer Hall, Chapel Hill, NC 27599 USA. EM exphys@live.unc.edu FU Intramural CDC HHS [CC999999] NR 47 TC 7 Z9 7 U1 3 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUL PY 2014 VL 46 IS 7 BP 1352 EP 1358 DI 10.1249/MSS.0000000000000232 PG 7 WC Sport Sciences SC Sport Sciences GA AJ5EO UT WOS:000337705300010 PM 24300125 ER PT J AU Saffell, BJ Meinzer, FC Voelker, SL Shaw, DC Brooks, JR Lachenbruch, B McKay, J AF Saffell, Brandy J. Meinzer, Frederick C. Voelker, Steven L. Shaw, David C. Brooks, J. Renee Lachenbruch, Barbara McKay, Jennifer TI Tree-ring stable isotopes record the impact of a foliar fungal pathogen on CO2 assimilation and growth in Douglas-fir SO PLANT CELL AND ENVIRONMENT LA English DT Article DE Phaeocryptopus gaeumannii; Pseudotsuga menziesii; stable isotopes; Swiss needle cast; tree-rings ID SWISS NEEDLE CAST; LEAF WATER; PHAEOCRYPTOPUS-GAEUMANNII; NONSTEADY STATE; COASTAL OREGON; CARBON; OXYGEN; LEAVES; PLANTS; DISCRIMINATION AB Swiss needle cast (SNC) is a fungal disease of Douglas-fir (Pseudotsuga menziesii) that has recently become prevalent in coastal areas of the Pacific Northwest. We used growth measurements and stable isotopes of carbon and oxygen in tree-rings of Douglas-fir and a non-susceptible reference species (western hemlock, Tsuga heterophylla) to evaluate their use as proxies for variation in past SNC infection, particularly in relation to potential explanatory climate factors. We sampled trees from an Oregon site where a fungicide trial took place from 1996 to 2000, which enabled the comparison of stable isotope values between trees with and without disease. Carbon stable isotope discrimination (Delta C-13) of treated Douglas-fir tree-rings was greater than that of untreated Douglas-fir tree-rings during the fungicide treatment period. Both annual growth and tree-ring Delta C-13 increased with treatment such that treated Douglas-fir had values similar to co-occurring western hemlock during the treatment period. There was no difference in the tree-ring oxygen stable isotope ratio between treated and untreated Douglas-fir. Tree-ring Delta C-13 of diseased Douglas-fir was negatively correlated with relative humidity during the two previous summers, consistent with increased leaf colonization by SNC under high humidity conditions that leads to greater disease severity in following years. C1 [Saffell, Brandy J.; Lachenbruch, Barbara] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [Meinzer, Frederick C.] US Forest Serv, Pacific NW Res Stn, USDA, Corvallis, OR 97331 USA. [Voelker, Steven L.] Southern Oregon Univ, Dept Biol, Ashland, OR 97520 USA. [Shaw, David C.] Oregon State Univ, Dept Forest Engn Resources & Management, Corvallis, OR 97331 USA. [Brooks, J. Renee] US EPA, Natl Hlth & Environm Effect Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [McKay, Jennifer] Oregon State Univ, Dept Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. RP Meinzer, FC (reprint author), US Forest Serv, Pacific NW Res Stn, USDA, Corvallis, OR 97331 USA. EM rick.meinzer@oregonstate.edu RI Voelker, Steven/O-2909-2014; OI Brooks, Renee/0000-0002-5008-9774 FU NSF [DEB-073882]; Swiss Needle Cast Cooperative FX This research was supported in part by NSF grant DEB-073882 and a grant from the Swiss Needle Cast Cooperative. We thank Alan Kanaskie of ODF for site access, and Danielle Marias, Joshua Petitmermet, Ben Roberts-Pierel, Holly Kearns, Kristen Falk and Regina Kurapova for their invaluable work in the field and lab. We also thank J. Johnstone for access to coastal Oregon fog data. This paper has been subjected to the Environmental Protection Agency's (EPA) peer and administrative review, and it has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 59 TC 4 Z9 4 U1 1 U2 22 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0140-7791 EI 1365-3040 J9 PLANT CELL ENVIRON JI Plant Cell Environ. PD JUL PY 2014 VL 37 IS 7 BP 1536 EP 1547 DI 10.1111/pce.12256 PG 12 WC Plant Sciences SC Plant Sciences GA AJ3CX UT WOS:000337544200005 PM 24330052 ER PT J AU Korajkic, A McMinn, BR Shanks, OC Sivaganesan, M Fout, GS Ashbolt, NJ AF Korajkic, Asja McMinn, Brian R. Shanks, Orin C. Sivaganesan, Mano Fout, G. Shay Ashbolt, Nicholas J. TI Biotic Interactions and Sunlight Affect Persistence of Fecal Indicator Bacteria and Microbial Source Tracking Genetic Markers in the Upper Mississippi River SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID 16S RIBOSOMAL-RNA; REAL-TIME PCR; RAPIDLY MEASURED INDICATORS; RECREATIONAL WATER-QUALITY; COMBINED SEWER OVERFLOWS; FRESH-WATER; ESCHERICHIA-COLI; QUANTITATIVE PCR; DIFFERENTIAL DECAY; SURFACE-WATER AB The sanitary quality of recreational waters that may be impacted by sewage is assessed by enumerating fecal indicator bacteria (FIB) (Escherichia coli and enterococci); these organisms are found in the gastrointestinal tracts of humans and many other animals, and hence their presence provides no information about the pollution source. Microbial source tracking (MST) methods can discriminate between different pollution sources, providing critical information to water quality managers, but relatively little is known about factors influencing the decay of FIB and MST genetic markers following release into aquatic environments. An in situ mesocosm was deployed at a temperate recreational beach in the Mississippi River to evaluate the effects of ambient sunlight and biotic interactions (predation, competition, and viral lysis) on the decay of culture-based FIB, as well as molecularly based FIB (Entero1a and GenBac3) and human-associated MST genetic markers (HF183 and HumM2) measured by quantitative real-time PCR (qPCR). In general, culturable FIB decayed the fastest, while molecularly based FIB and human-associated genetic markers decayed more slowly. There was a strong correlation between the decay of molecularly based FIB and that of human-associated genetic markers (r(2), 0.96 to 0.98; P< 0.0001) but not between culturable FIB and any qPCR measurement. Overall, exposure to ambient sunlight may be an important factor in the early-stage decay dynamics but generally was not after continued exposure (i. e., after 120 h), when biotic interactions tended to be the only/major influential determinant of persistence. C1 [Korajkic, Asja; McMinn, Brian R.; Fout, G. Shay; Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Shanks, Orin C.; Sivaganesan, Mano] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Korajkic, A (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. EM korajkic.asja@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. NR 70 TC 10 Z9 10 U1 5 U2 38 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUL PY 2014 VL 80 IS 13 BP 3952 EP 3961 DI 10.1128/AEM.00388-14 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AI9GR UT WOS:000337241400019 PM 24747902 ER PT J AU Breitner, S Wolf, K Devlin, RB Diaz-Sanchez, D Peters, A Schneider, A AF Breitner, Susanne Wolf, Kathrin Devlin, Robert B. Diaz-Sanchez, David Peters, Annette Schneider, Alexandra TI Short-term effects of air temperature on mortality and effect modification by air pollution in three cities of Bavaria, Germany: A time-series analysis SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Air temperature; Cause-specific mortality; Effect modification; Age groups; Air pollution ID CASE-CROSSOVER ANALYSIS; HEAT-RELATED MORTALITY; 15 EUROPEAN CITIES; RED-CELL COUNTS; UNITED-STATES; AMBIENT-TEMPERATURE; MYOCARDIAL-INFARCTION; CEREBRAL THROMBOSIS; PARTICULATE MATTER; BLOOD-VISCOSITY AB Background: Air temperature has been shown to be associated with mortality; however, only very few studies have been conducted in Germany. This study examined the association between daily air temperature and cause-specific mortality in Bavaria, Southern Germany. Moreover, we investigated effect modification by age and ambient air pollution. Methods: We obtained data from Munich, Nuremberg as well as Augsburg, Germany, for the period 1990 to 2006. Data included daily cause-specific death counts, mean daily meteorology and air pollution concentrations (particulate matter with a diameter <10 mu m [PM10] and maximum 8-h ozone). We used Poisson regression models combined with distributed lag non-linear models adjusting for long-term trend, calendar effects, and meteorological factors. Air pollutant concentrations were categorized into three levels, and an interaction term was included to quantify potential effect modification of the air temperature effects. Results: The temperature-mortality relationships were non-linear for all cause-specific mortality categories showing U- or J-shaped curves. An increase from the 90th (20.0 degrees C) to the 99th percentile (24.8 degrees C) of 2-day average temperature led to an increase in non-accidental mortality by 11.4% (95% CI: 7.6%-15.3%), whereas a decrease from the 10th (-1.0 degrees C) to the 1st percentile (-7.5 degrees C) in the 15-day average temperature resulted in an increase of 6.2% (95% CI: 1.8%-10.8%). The very old were found to be most susceptible to heat effects. Results also suggested some effect modification by ozone, but not for PM10. Conclusions: Results indicate that both very low and very high air temperature increase cause-specific mortality in Bavaria. Results also pointed to the importance of considering effect modification by age and ozone in assessing temperature effects on mortality. (C) 2014 Elsevier BY. All rights reserved. C1 [Breitner, Susanne; Wolf, Kathrin; Peters, Annette; Schneider, Alexandra] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherberg, Germany. [Devlin, Robert B.; Diaz-Sanchez, David] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA. RP Breitner, S (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. EM susanne.breitner@helmholtz-muenchen.de RI Breitner, Susanne/B-5348-2014; Peters, Annette/A-6117-2011; Schneider, Alexandra/B-5347-2014 OI Breitner, Susanne/0000-0002-0956-6911; FU Bavarian State Ministry of the Environment and Public Health; U.S. Environmental Protection Agency (EPA) [PR-ORD-11-00199]; Helmholtz Network "Regional Climate Change" (REKLIM)" FX This study was funded by the Bavarian State Ministry of the Environment and Public Health, by the U.S. Environmental Protection Agency (EPA) (PR-ORD-11-00199) and the Helmholtz Network "Regional Climate Change" (REKLIM)". We would like to thank the Bavarian State Office for Statistics and Data Processing, the Bavarian Environment Agency and the German Weather Service for providing data on mortality, meteorology and air pollution. NR 51 TC 17 Z9 20 U1 2 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUL 1 PY 2014 VL 485 BP 49 EP 61 DI 10.1016/j.scitotenv.2014.03.048 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA AI9NJ UT WOS:000337259000006 PM 24704956 ER PT J AU Mohapatra, DP Brar, SK Daghrir, R Tyagi, RD Picard, P Surampalli, RY Drogui, P AF Mohapatra, D. P. Brar, S. K. Daghrir, R. Tyagi, R. D. Picard, P. Surampalli, R. Y. Drogui, P. TI Photocatalytic degradation of carbamazepine in wastewater by using a new class of whey-stabilized nanocrystalline TiO2 and ZnO SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Carbamazepine; Photocatalysis; Yeast estrogen screen assay; Whey stabilizer; Wastewater ID TANDEM MASS-SPECTROMETRY; SURFACE MODIFICATION; NANOPARTICLES; PHARMACEUTICALS; CONTAMINANTS; ENVIRONMENT; PRODUCTS; REMOVAL AB Nanoscale photocatalysts have attracted much attention due to their high surface area to volume ratios. However, due to extremely high reactivity, TiO2 and ZnO nanoparticles prepared using different methods tend to either react with surrounding media or agglomerate, resulting in the formation of much larger flocs and significant loss in reactivity. This work investigates the photocatalytic degradation of carbamazepine (CBZ), a persistent pharmaceutical compound from wastewater (WW) using TiO2 and ZnO nanoparticles prepared in the presence of a water-soluble whey powder as stabilizer. The TiO2 and ZnO nanoparticles prepared in the presence of whey stabilizer displayed much less agglomeration and greater degradation power than those prepared without a stabilizer. Higher photocatalytic degradation of carbamazepine was observed (100%) by using whey stabilized TiO2 nanoparticles with 55 min irradiation time as compared to ZnO nanoparticles (92%). The higher degradation of CBZ in wastewater by using TiO2 nanoparticles as compared to ZnO nanoparticles was due to formation of higher photo-generated holes with high oxidizing power of TiO2. The photocatalytic capacity of ZnO anticipated as similar to that of TiO2 as it has the same band gap energy (3.2 eV) as TiO2. However, in the case of ZnO, photocorrosion frequently occurs with the illumination of UV light and this phenomenon is considered as one of the main reasons for the decrease of ZnO photocatalytic activity in aqueous solutions. Further, the estrogenic activity of photocatalyzed WW sample with CBZ and its by-products was carried out by yeast estrogen screen (YES) assay method. Based upon the YES test results, none of the samples showed estrogenic activity. (C) 2014 Elsevier B.V. All rights reserved. C1 [Mohapatra, D. P.; Brar, S. K.; Daghrir, R.; Tyagi, R. D.; Drogui, P.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada. [Picard, P.] Phytronix Technol, Quebec City, PQ G1P 2J7, Canada. [Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA. RP Brar, SK (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada. EM satinder.brar@ete.inrs.ca FU Natural Sciences and Engineering Research Council of Canada [355254]; Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT); Quebec; Natural Sciences and Engineering Research Council of Canada (NSERC) FX The authors are thankful to the Natural Sciences and Engineering Research Council of Canada (Discovery Grant 355254) for financial support. Thanks to the Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT), Quebec, Natural Sciences and Engineering Research Council of Canada (NSERC) for providing Industrial Innovation scholarships (BMP Innovation) to D.P. Mohapatra. The views or opinions expressed in this article are those of the authors and should not be construed as opinions of the U.S. Environmental Protection Agency. NR 19 TC 13 Z9 13 U1 3 U2 64 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUL 1 PY 2014 VL 485 BP 263 EP 269 DI 10.1016/j.scitotenv.2014.03.089 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AI9NJ UT WOS:000337259000026 PM 24727044 ER PT J AU Voorhees, AS Wang, JD Wang, CC Zhao, B Wang, SX Kan, HD AF Voorhees, A. Scott Wang, Jiandong Wang, Cuicui Zhao, Bin Wang, Shuxiao Kan, Haidong TI Public health benefits of reducing air pollution in Shanghai: A proof-of-concept methodology with application to BenMAP SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Air pollution; Health benefits; China; Environment; Pollution valuation ID PARTICULATE MATTER POLLUTION; STRATIFIED CASE-CROSSOVER; DAILY MORTALITY; ECONOMIC-ASSESSMENT; CHINESE CITIES; CONTINGENT VALUATION; CONTROL POLICIES; URBAN AREAS; ASIA PAPA; PM2.5 AB In recent years, levels of particulate matter (PM) air pollution in China have been relatively high, exceeding China's Class II standards in many cities and impacting public health. This analysis takes Chinese health impact functions and underlying health incidence, applies 2010-2012 modeled and monitored PM air quality data, and estimates avoided cases of mortality and morbidity in Shanghai, assuming achievement of China's Class II air quality standards. In Shanghai, the estimated avoided all cause mortality due to PM10, ranged from 13 to 55 cases per day and from 300 to 800 cases per year. The estimated avoided impact on hospital admissions due to PM10, ranged from 230 cases to 580 cases per day and from 5400 to 7900 per year. The estimated avoided impact on all cause mortality due to PM2.5 ranged from 6 to 26 cases per day and from 39 to 1400 per year. The estimated impact on all cause mortality of a year exposure to an annual or monthly mean PM2.5 concentration ranged from 180 to 3500 per year. In Shanghai, the avoided cases of all cause mortality had an estimated monetary value ranging from 170 million yuan (1 US dollar = 4.2 yuan Purchasing Power Parity) to 1200 million yuan. Avoided hospital admissions had an estimated value from 20 to 43 million yuan. Avoided emergency department visits had an estimated value from 5.6 million to 15 million yuan. Avoided outpatient visits had an estimated value from 21 million to 31 million yuan. In this analysis, available data were adequate to estimate avoided health impacts and assign monetary value. Sufficient supporting documentation was available to construct and format data sets for use in the United States Environmental Protection Agency's health and environmental assessment model, known as the Environmental Benefits Mapping and Analysis Program - Community Edition ("BenMAP-CE"). Published by Elsevier B.V. C1 [Voorhees, A. Scott] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Wang, Jiandong; Zhao, Bin; Wang, Shuxiao] Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China. [Wang, Jiandong; Zhao, Bin; Wang, Shuxiao] Tsinghua Univ, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. [Wang, Cuicui; Kan, Haidong] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China. RP Voorhees, AS (reprint author), US EPA, Off Air Qual Planning & Stand, Mail Code C504-04, Res Triangle Pk, NC 27711 USA. EM voorhees.scott@epa.gov; wangjd11@mails.tsinghua.edu.cn; happymonan@163.com; zhaob06@mails.tsinghua.edu.cn; shxwang@tsinghua.edu.cn; kanh@fudan.edu.cn RI Wang, Jiandong/O-1863-2015; wang, shuxiao/H-5990-2011; OI Wang, Jiandong/0000-0003-3000-622X; wang, shuxiao/0000-0001-9727-1963; , Cuicui/0000-0002-0540-873X FU US Fulbright Scholar program FX We thank EPA colleagues Jia Xing, Charles Fulcher, Neal Fann, Carey Jang, Bryan Hubbell and Dale Evarts for their encouragement and advice, and Song Gao of the Shanghai Environmental Monitoring Center for his instruction in accessing monitored air quality data. A special appreciation goes to Tsinghua University for providing work space and assistance during the research phase of this analysis. Finally, we thank Dian Ding and Yun Zhu at South China University of Technology for their assistance in proper BenMAP file formatting. This study was supported by a fellowship from the US Fulbright Scholar program. NR 70 TC 18 Z9 19 U1 12 U2 67 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUL 1 PY 2014 VL 485 BP 396 EP 405 DI 10.1016/j.scitotenv.2014.03.113 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA AI9NJ UT WOS:000337259000040 PM 24742548 ER PT J AU Brown, S Mahoney, M Sprenger, M AF Brown, Sally Mahoney, Michele Sprenger, Mark TI A comparison of the efficacy and ecosystem impact of residual-based and topsoil-based amendments for restoring historic mine tailings in the Tri-State mining district SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Mine waste; Biosolids; Soil formation; Ecosystem services; Top-soil harvesting ID LAND APPLICATION; UNITED-STATES; SMALL MAMMALS; SOIL-EROSION; NEW-ZEALAND; BIOSOLIDS; LEAD; SUSTAINABILITY; SERVICES; GENESIS AB A long-term research and demonstration site was established on Pb and Zn mine wastes in southwestern Missouri in 1999. Municipal biosolids and lime and composts were mixed into the wastes at different loading rates. The site was monitored intensively after establishment and again in 2012. A site restored with topsoil was also included in the 2012 sampling. Initial results including plant, earthworm and small mammal assays indicate that the bioaccessibility of metals had been significantly reduced as a result of amendment addition. The recent sampling showed that at higher loading rates, the residual mixtures have maintained a vegetative cover and are similar to the topsoil treatment based on nutrient availability and cycling and soil physical properties including bulk density and water holding capacity. The ecosystem implications of restoration with residuals versus mined topsoil were evaluated. Harvesting topsoil from nearby farms would require 1875 years to replace based on natural rates of soil formation. In contrast diverting biosolids from combustion facilities (60% of biosolids generated in Missouri are incinerated) would result in greenhouse gas savings of close to 400 Mg CO2 per ha. (C) 2014 Elsevier B.V. All rights reserved. C1 [Brown, Sally] Univ Washington, Sch Forest & Environm Sci, Seattle, WA 98105 USA. [Mahoney, Michele; Sprenger, Mark] US EPA, Environm Response Team, Edison, NJ USA. RP Brown, S (reprint author), Univ Washington, Sch Forest & Environm Sci, Seattle, WA 98105 USA. EM slb@uw.edu NR 54 TC 7 Z9 7 U1 3 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUL 1 PY 2014 VL 485 BP 624 EP 632 DI 10.1016/j.scitotenv.2014.03.029 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AI9NJ UT WOS:000337259000065 PM 24747254 ER PT J AU Annys, E Billington, R Clayton, R Bremm, KD Graziano, M McKelvie, J Ragan, I Schwarz, M van der Laan, JW Wood, C Oberg, M Wester, P Woodward, KN AF Annys, Erwin Billington, Richard Clayton, Rick Bremm, Klaus-Dieter Graziano, Michael McKelvie, Jo Ragan, Ian Schwarz, Michael van der Laan, Jan Willem Wood, Charles Oberg, Mattias Wester, Piet Woodward, Kevin N. TI Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Carcinogenicity; Pharmaceuticals; Veterinary drugs; Chemicals; Plant protection; Genotoxicity; Reduction; Replacement; Refinement; Transgenic ID CELL-TRANSFORMATION ASSAYS; MOUSE CARCINOGENICITY; INDUSTRY PERSPECTIVE; MEDICINAL PRODUCTS; SAFETY ASSESSMENT; RISK ASSESSMENT; NO LONGER; RODENT; PHARMACEUTICALS; CHEMICALS AB Different government agencies operating in the European Union regulate different types of chemical products but all require testing for carcinogenicity to support applications for product marketing and commercialisation. A conference was held in Brussels in 2013 where representatives of the pharmaceutical, animal health, chemical and plant protection industries, together with representatives of regulatory agencies, universities and other stakeholders, met under the auspices of The European Partnership for Alternative Approaches to Animal Testing (EPAA) to discuss the varying requirements for carcinogenicity testing, and how these studies might be refined to improve hazard evaluation and risk assessment while implementing principles of the 3Rs (replacement, refinement and reduction in animal studies). While there are some similarities, the regulatory approaches in pharmaceutical, animal health, chemical and plant protection sectors have varying degrees of flexibility in requirements for carcinogenicity testing, to an extent reflecting concerns over the magnitude and duration of human exposure, either directly as in therapeutic exposure to pharmaceuticals, or indirectly through the ingestion of residues of veterinary drugs or plant protection chemicals. The article discusses these differences and other considerations for modified carcinogenicity testing paradigms on the basis of scientific and 3Rs approaches. (C) 2014 Elsevier Inc. All rights reserved. C1 [Annys, Erwin] CEFIC, Brussels, Belgium. [Billington, Richard] Dow AgroSci, Abingdon, Oxon, England. [Clayton, Rick] IFAH Europe, Brussels, Belgium. [Bremm, Klaus-Dieter] Bayer Pharma AG, Wuppertal, Germany. [Graziano, Michael] Bristol Myers Squibb, Princeton, NJ USA. [McKelvie, Jo] Evita Serv, Craigavon, North Ireland. [Ragan, Ian] European Partnership Alternat Anim Testing EPAA, Brussels, Belgium. [Schwarz, Michael] Univ Tubingen, Tubingen, Germany. [van der Laan, Jan Willem] Med Evaluat Board, Utrecht, Netherlands. [Wood, Charles] Environm Protect Agcy, Res Triangle Pk, NC USA. [Oberg, Mattias] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. [Wester, Piet] RIVM, Bilthoven, Netherlands. [Woodward, Kevin N.] TSGE Consulting Ltd Knaresborough, Harrogate, England. RP Woodward, KN (reprint author), TSGE Consulting Ltd, Concordia House,St James Business Pk, Knaresborough HG5 8QB, N Yorkshire, England. EM Kevin.Woodward@TSGEurope.com OI Oberg, Mattias/0000-0001-5377-530X NR 58 TC 9 Z9 10 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD JUL PY 2014 VL 69 IS 2 BP 234 EP 242 DI 10.1016/j.yrtph.2014.04.009 PG 9 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AI7KQ UT WOS:000337069800010 PM 24768934 ER PT J AU Jones, EH Su, CM AF Jones, Edward H. Su, Chunming TI Transport and retention of zinc oxide nanoparticles in porous media: Effects of natural organic matter versus natural organic ligands at circumneutral pH SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Nanoparticles; Zinc oxide; Natural organic matter; Natural organic ligands; Fate and transport ID ZNO NANOPARTICLES; IONIC-STRENGTH; PARTICLE-SIZE; AGGREGATION KINETICS; C-60 NANOPARTICLES; CARBON NANOTUBES; AQUEOUS-PHASE; HUMIC-ACID; DEPOSITION; FULLERENE AB The potential toxicity of nanoparticles (NPs) has received considerable attention, but there is little knowledge relating to the fate and transport of engineered ZnO NPs in the environment. Column experiments were performed at pH 7.3-7.6 to generate effluent concentrations and retention profiles for assessing the fate and transport of ZnO NPs (PZC = 9.3, nominal size 20 nm) in saturated quartz sands (256 mu m) in the presence of low natural organic matter (NOM) concentrations (1 mg/L humic and fulvic acids) and millimolar natural organic ligands (NOL) levels (formic, oxalic, and citric acids). At circumneutral pHs, ZnO NPs were positively charged and immobile in sand. The presence of NOM decreased the attachment efficiency facilitating ZnO transport through sand columns. Conversely, ZnO transport in the presence of formic and oxalic acids was only slightly improved when compared to ZnO in DI water; whereas, citric acid showed no improvement. The distinct difference between NOM and NOL may have important implications with regard to ZnO transport in the subsurface environment. Experimental results suggested the presence of both favorable and unfavorable nanoparticle interactions causes significant deviations from classical colloid filtration theory (CFT). (C) 2014 Elsevier B.V. All rights reserved. C1 [Jones, Edward H.; Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, Ada, OK 74820 USA. RP Jones, EH (reprint author), Geosyntec Consultants Inc, 11490 Westheimer,Suite 150, Houston, TX 77077 USA. EM edwdjones@hotmail.com FU National Research Council Resident Research Associateship Award at the Robert; U.S. Environmental Protection Agency through its Office of Research and Development FX This research was performed while the first author held a National Research Council Resident Research Associateship Award at the Robert. S. Kerr Environmental Research Center, US EPA, Ada, OK. Laboratory sample digestion analysis was undertaken onsite by Shaw Environmental Inc. The work upon which this paper is based was supported by the U.S. Environmental Protection Agency through its Office of Research and Development. This work has not been subjected to agency review and, therefore, doesn't necessarily reflect the views of the agency and no official endorsement should be inferred. Any product or trade name mentioned here is for information purposes only and not to constitute endorsement. NR 39 TC 9 Z9 9 U1 4 U2 64 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUN 30 PY 2014 VL 275 BP 79 EP 88 DI 10.1016/j/jhazmat.2014.04.058 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AL5AU UT WOS:000339146700010 PM 24853139 ER PT J AU Mallard, MS Nolte, CG Bullock, OR Spero, TL Gula, J AF Mallard, Megan S. Nolte, Christopher G. Bullock, O. Russell Spero, Tanya L. Gula, Jonathan TI Using a coupled lake model with WRF for dynamical downscaling SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID REGIONAL CLIMATE MODEL; LAURENTIAN GREAT-LAKES; EFFECT SNOWFALL; SURFACE TEMPERATURE; ICE COVER; SIMULATION; RESOLUTION; SYSTEM; IMPLEMENTATION; SENSITIVITY AB The Weather Research and Forecasting (WRF) model is used to downscale a coarse reanalysis (National Centers for Environmental Prediction-Department of Energy Atmospheric Model Intercomparison Project reanalysis, hereafter R2) as a proxy for a global climate model (GCM) to examine the consequences of using different methods for setting lake temperatures and ice on predicted 2 m temperature and precipitation in the Great Lakes region. A control simulation is performed where lake surface temperatures and ice coverage are interpolated from the GCM proxy. Because the R2 represents the five Great Lakes with only three grid points, ice formation is poorly represented, with large, deep lakes freezing abruptly. Unrealistic temperature gradients appear in areas where the coarse-scale fields have no inland water points nearby and lake temperatures on the finer grid are set using oceanic points from the GCM proxy. Using WRF coupled with the Freshwater Lake (FLake) model reduces errors in lake temperatures and significantly improves the timing and extent of ice coverage. Overall, WRF-FLake increases the accuracy of 2 m temperature compared to the control simulation where lake variables are interpolated from R2. However, the decreased error in FLake-simulated lake temperatures exacerbates an existing wet bias in monthly precipitation relative to the control run because the erroneously cool lake temperatures interpolated from R2 in the control run tend to suppress overactive precipitation. C1 [Mallard, Megan S.; Nolte, Christopher G.; Bullock, O. Russell; Spero, Tanya L.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Gula, Jonathan] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA. RP Mallard, MS (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM megansmallard@gmail.com RI Nolte, Christopher/H-4345-2012; Gula, Jonathan/J-9925-2012; OI Nolte, Christopher/0000-0001-5224-9965; Gula, Jonathan/0000-0002-0876-9557; Spero, Tanya/0000-0002-1600-0422 FU Research Participation Program at the U.S. Environmental Protection Agency Office of Research and Development; National Science Foundation FX The lead author was supported by an appointment to the Research Participation Program at the U.S. Environmental Protection Agency Office of Research and Development, administered by the Oak Ridge Institute for Science and Education (ORISE). The WRF model is made available by NCAR, funded by the National Science Foundation. We thank Jiming Jin and Lin Zhao of Utah State University for providing code for processing the NIC ice data. Thanks also to Kiran Alapaty for his contributions to the manuscript. The authors also appreciate the helpful comments of two anonymous reviewers on this article. The University of Delaware precipitation data were provided by the NOAA/OAR/ESRL PSD, Boulder, Colorado, USA, from their website at http://www.esrl.noaa.gov/psd/. This research has been subjected to the U.S. EPA's administrative review and approved for publication. The views expressed and the contents are solely the responsibility of the authors and do not necessarily represent the official views of the U.S. EPA. NR 49 TC 8 Z9 8 U1 0 U2 22 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JUN 27 PY 2014 VL 119 IS 12 BP 7193 EP 7208 DI 10.1002/2014JD021785 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AN0BP UT WOS:000340247000012 ER PT J AU Cherkasov, A Muratov, EN Fourches, D Varnek, A Baskin, II Cronin, M Dearden, J Gramatica, P Martin, YC Todeschini, R Consonni, V Kuz'min, VE Cramer, R Benigni, R Yang, CH Rathman, J Terfloth, L Gasteiger, J Richard, A Tropsha, A AF Cherkasov, Artem Muratov, Eugene N. Fourches, Denis Varnek, Alexandre Baskin, Igor I. Cronin, Mark Dearden, John Gramatica, Paola Martin, Yvonne C. Todeschini, Roberto Consonni, Viviana Kuz'min, Victor E. Cramer, Richard Benigni, Romualdo Yang, Chihae Rathman, James Terfloth, Lothar Gasteiger, Johann Richard, Ann Tropsha, Alexander TI QSAR Modeling: Where Have You Been? Where Are You Going To? SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QUANTITATIVE STRUCTURE-ACTIVITY; HELICAL ANTIMICROBIAL PEPTIDES; AUTOMATED STRUCTURE EVALUATION; NANO-COMBINATORIAL CHEMISTRY; PREDICTING MIXTURE TOXICITY; SUPPORT VECTOR MACHINE; AMINO-ACID DESCRIPTORS; COMPUTER-AIDED-DESIGN; IN-SILICO TOOLS; BIOLOGICAL-ACTIVITY AB Quantitative structure-activity relationship modeling is one of the major computational tools employed in medicinal chemistry. However, throughout its entire history it has drawn both praise and criticism concerning its reliability, limitations, successes, and failures. In this paper, we discuss (i) the development and evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) several novel and emerging applications of QSAR modeling. Throughout this discussion, we provide guidelines for QSAR development, validation, and application, which are summarized in best practices for building rigorously validated and externally predictive QSAR models. We hope that this Perspective will help communications between computational and experimental chemists toward collaborative development and use of QSAR models. We also believe that the guidelines presented here will help journal editors and reviewers apply more stringent scientific standards to manuscripts reporting new QSAR studies, as well as encourage the use of high quality, validated QSARs for regulatory decision making. C1 [Cherkasov, Artem] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada. [Muratov, Eugene N.; Fourches, Denis; Tropsha, Alexander] Univ N Carolina, UNC Eshelman Sch Pharm, Lab Mol Modeling, Chapel Hill, NC 27599 USA. [Muratov, Eugene N.; Kuz'min, Victor E.] Natl Acad Sci Ukraine, AV Bogatsky Phys Chem Inst, Dept Mol Struct & Cheminformat, UA-65080 Odessa, Ukraine. [Varnek, Alexandre] L Pasteur Univ Strasbourg, Dept Chem, F-67000 Strasbourg, France. [Baskin, Igor I.] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. [Cronin, Mark; Dearden, John] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England. [Gramatica, Paola] Univ Insubria, Dept Struct & Funct Biol, I-21100 Varese, Italy. [Martin, Yvonne C.] Martin Consulting, Waukegan, IL 60079 USA. [Todeschini, Roberto; Consonni, Viviana] Univ Milano Bicocca, Milano Chemometr & QSAR Res Grp, I-20126 Milan, Italy. [Cramer, Richard] Tripos Inc, St Louis, MO 63144 USA. [Benigni, Romualdo] Ist Super Sanita, Environm & Hlth Dept, I-00161 Rome, Italy. [Yang, Chihae; Rathman, James] Altamira LLC, Columbus, OH 43235 USA. [Rathman, James] Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43215 USA. [Terfloth, Lothar; Gasteiger, Johann] Mol Networks GmbH, D-91052 Erlangen, Germany. [Richard, Ann] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27519 USA. RP Tropsha, A (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Lab Mol Modeling, Chapel Hill, NC 27599 USA. EM alex_tropsha@unc.edu RI Cherkasov, Artem/A-2134-2012; Muratov, Eugene/C-4454-2014; Baskin, Igor/I-2490-2012; Todeschini, Roberto/B-5868-2014; Varnek, Alexandre/E-7076-2017; OI Muratov, Eugene/0000-0003-4616-7036; Baskin, Igor/0000-0003-0874-1148; Todeschini, Roberto/0000-0002-6454-4192; Varnek, Alexandre/0000-0003-1886-925X; Consonni, Viviana/0000-0001-6252-9805; Gramatica, Paola/0000-0002-6364-6138 FU NIH [GM096967, GM066940]; EPA [RD 83499901]; Natural Sciences and Engineering Research Council of Canada FX This review combined a series of separately written, invited contributions from the various coauthors (some sections with multiple coauthors). Primary attributions for the various contributed sections are as follows: 2.1, Y. Martin; 2.2, V. Consonni, R. Todeschini, and R. Cramer; 2.3, J. Dearden and M. Cronin; 3.1, D. Fourches, E. Muratov, and A. Tropsha; 3.2, A. Benigni, C. Yang, J. Rathman, and A. Richard; 3.3, L. Terfloth and J. Gasteiger; 3.4, V. Kuz'min and E. Muratov; 3.5, I. Baskin and A. Varnek; 3.6, D. Fourches and A. Tropsha; 4.1, A. Cherkasov; 4.2, E. Muratov and V. Kuz'min; 4.3, D. Fourches; 5., P. Gramatica; 6, A. Tropsha. Figures were done by D. Fourches and E. Muratov. Substantial assistance in editing of all contributions was provided by A. Cherkasov and A. Richard, and final editing was accomplished by A. Tropsha, who also takes primary responsibility for the final content. The senior author (A.T.) also appreciates the support provided to his lab by NIH (Grants GM096967 and GM066940) and EPA (Grant RD 83499901). The first author (A.C.) acknowledges the support from the Natural Sciences and Engineering Research Council of Canada (Discovery Grants Program). The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency and other research institutions. Mentioning of trade names or commercial products does not constitute endorsement or recommendation for use. NR 279 TC 149 Z9 156 U1 31 U2 167 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD JUN 26 PY 2014 VL 57 IS 12 BP 4977 EP 5010 DI 10.1021/jm4004285 PG 34 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA AK1OJ UT WOS:000338184100001 PM 24351051 ER PT J AU Grear, JS Koethe, R Hoskins, B Hillger, R Dapsis, L Pongsiri, M AF Grear, Jason S. Koethe, Robert Hoskins, Bart Hillger, Robert Dapsis, Larry Pongsiri, Montira TI The effectiveness of permethrin-treated deer stations for control of the Lyme disease vector Ixodes scapularis on Cape Cod and the islands: a five-year experiment SO PARASITES & VECTORS LA English DT Article DE Ixodes scapularis; Tick; Permethrin; 4-poster; Feeding station; Host-targeted control; Lyme disease; Borrelia burgdorferi; Odocoileus virginianus; White-tailed deer; Blacklegged tick ID WHITE-TAILED DEER; TICK CONTROL PROJECT; UNITED-STATES; REDUCED ABUNDANCE; TOPICAL TREATMENT; ACARI IXODIDAE; DAMMINI; AREA; COMMUNITY; EFFICACY AB Background: The use of animal host-targeted pesticide application to control blacklegged ticks, which transmit the Lyme disease bacterium between wildlife hosts and humans, is receiving increased attention as an approach to Lyme disease risk management. Included among the attractive features of host-targeted approaches is the reduced need for broad-scale pesticide usage. In the eastern USA, one of the best-known of these approaches is the corn-baited "4-poster" deer feeding station, so named because of the four pesticide-treated rollers that surround the bait troughs. Wildlife visitors to these devices receive an automatic topical application of acaricide, which kills attached ticks before they can reproduce. We conducted a 5-year controlled experiment to estimate the effects of 4-poster stations on tick populations in southeastern Massachusetts, where the incidence of Lyme disease is among the highest in the USA. Methods: We deployed a total of forty-two 4-posters among seven treatment sites and sampled for nymph and adult ticks at these sites and at seven untreated control sites during each year of the study. Study sites were distributed among Cape Cod, Martha's Vineyard, and Nantucket. The density of 4-poster deployment was lower than in previous 4-poster studies and resembled or possibly exceeded the levels of effort considered by county experts to be feasible for Lyme disease risk managers. Results: Relative to controls, blacklegged tick abundance at treated sites was reduced by approximately 8.4%, which is considerably less than in previous 4-poster studies. Conclusions: In addition to the longer duration and greater replication in our study compared to others, possible but still incomplete explanations for the smaller impact we observed include the lower density of 4-poster deployment as well as landscape and mammalian community characteristics that may complicate the ecological relationship between white-tailed deer and blacklegged tick populations. C1 [Grear, Jason S.] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Koethe, Robert; Hoskins, Bart; Hillger, Robert] US EPA, Boston, MA 02109 USA. [Dapsis, Larry] Cape Cod Cooperat Extens Serv, Barnstable, MA 02630 USA. [Pongsiri, Montira] US EPA, Off Res & Dev, Washington, DC 20450 USA. RP Grear, JS (reprint author), US EPA, Off Res & Dev, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM grear.jason@epa.gov FU Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency (EPA) [ORD-004097]; EPA FX We dedicate this work to the memory of David Simser, whose passions about sustainable solutions to Lyme disease led him to lay the foundation for this study. We also thank Peter McCormack and David Thompson for their tireless effort and dedication in the field work and William Clark for his contributions to planning discussions and outreach. Dan Campbell, Betty Kreakie, and Brenda Rashleigh provided thoughtful comments on an earlier version of the manuscript. This manuscript was submitted with tracking number ORD-004097 by the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency (EPA). Although the research described in this article was funded by EPA, it has not been subjected to agency review and does not necessarily reflect the views of the agency. NR 33 TC 5 Z9 5 U1 1 U2 34 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD JUN 25 PY 2014 VL 7 AR 292 DI 10.1186/1756-3305-7-292 PG 8 WC Parasitology SC Parasitology GA AK4DK UT WOS:000338374000001 PM 24965139 ER PT J AU Zhang, J Hsieh, JH Zhu, H AF Zhang, Jun Hsieh, Jui-Hua Zhu, Hao TI Profiling Animal Toxicants by Automatically Mining Public Bioassay Data: A Big Data Approach for Computational Toxicology SO PLOS ONE LA English DT Article ID PUBCHEM; MANAGEMENT; CHEMICALS; TOXICITY; ASSAYS AB In vitro bioassays have been developed and are currently being evaluated as potential alternatives to traditional animal toxicity models. Already, the progress of high throughput screening techniques has resulted in an enormous amount of publicly available bioassay data having been generated for a large collection of compounds. When a compound is tested using a collection of various bioassays, all the testing results can be considered as providing a unique bio-profile for this compound, which records the responses induced when the compound interacts with different cellular systems or biological targets. Profiling compounds of environmental or pharmaceutical interest using useful toxicity bioassay data is a promising method to study complex animal toxicity. In this study, we developed an automatic virtual profiling tool to evaluate potential animal toxicants. First, we automatically acquired all PubChem bioassay data for a set of 4,841 compounds with publicly available rat acute toxicity results. Next, we developed a scoring system to evaluate the relevance between these extracted bioassays and animal acute toxicity. Finally, the top ranked bioassays were selected to profile the compounds of interest. The resulting response profiles proved to be useful to prioritize untested compounds for their animal toxicity potentials and form a potential in vitro toxicity testing panel. The protocol developed in this study could be combined with structure-activity approaches and used to explore additional publicly available bioassay datasets for modeling a broader range of animal toxicities. C1 [Zhang, Jun; Zhu, Hao] Rutgers State Univ, Dept Chem, Camden, NJ 08102 USA. [Zhang, Jun; Zhu, Hao] Rutgers Ctr Computat & Integrat Biol, Camden, NJ USA. [Hsieh, Jui-Hua] Natl Inst Environm Hlth Sci, Div Natl Toxicol Program, Biomol Screening Branch, Res Triangle Pk, NC USA. RP Zhu, H (reprint author), Rutgers State Univ, Dept Chem, Camden, NJ 08102 USA. EM hao.zhu99@rutgers.edu FU National Institute of Environmental Health Sciences of the National Institutes of Health [R15ES023148]; Colgate-Palmolive Grant for Alternative Research FX This work was supported, in part, by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number [R15ES023148] and the Colgate-Palmolive Grant for Alternative Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. https://www.niehs.nih.gov/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 28 TC 6 Z9 6 U1 3 U2 35 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 20 PY 2014 VL 9 IS 6 AR e99863 DI 10.1371/journal.pone.0099863 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK2UZ UT WOS:000338276300021 PM 24950175 ER PT J AU Route, WT Key, RL Russell, RE Lindstrom, AB Strynar, MJ AF Route, William T. Key, Rebecca L. Russell, Robin E. Lindstrom, Andrew B. Strynar, Mark J. TI Spatial and Temporal Patterns in Concentrations of Perfluorinated Compounds in Bald Eagle Nestlings in the Upper Midwestern United States SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERFLUOROOCTANOIC ACID PFOA; UPPER MISSISSIPPI RIVER; GREAT-LAKES; DRINKING-WATER; HUMAN-PLASMA; HUMAN-SERUM; SULFONATE; CONTAMINANTS; FISH; IDENTIFICATION AB Perfluorinated chemicals (PFCs) are of concern due to their widespread use, persistence in the environment, tendency to accumulate in animal tissues, and growing evidence of toxicity. Between 2006 and 2011 we collected blood plasma from 261 bald eagle nestlings in six study areas from the upper Midwestern United States. Samples were assessed for levels of 16 different PFCs. We used regression analysis in a Bayesian framework to evaluate spatial and temporal trends for these analytes. We found levels as high as 7370 ng/mL for the sum of all 16 PFCs (Sigma PFCs). Perfluorooctanesulfonate (PFOS) and perfluorodecanesulfonate (PFDS) were the most abundant analytes, making up 67% and 23% of the PFC burden, respectively. Levels of Sigma PFC, PFOS, and PFDS were highest in more urban and industrial areas, moderate on Lake Superior, and low on the remote upper St. Croix River watershed. We found evidence of declines in Sigma PFCs and seven analytes, including PFOS, PFDS, and perfluorooctanoic acid (PFOA); no trend in two analytes; and increases in two analytes. We argue that PFDS, a long-chained PFC with potential for high bioaccumulation and toxicity, should be considered for future animal and human studies. C1 [Route, William T.; Key, Rebecca L.] Natl Pk Serv, Great Lakes Inventory & Monitoring Network, Ashland, WI 54806 USA. [Russell, Robin E.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA. [Lindstrom, Andrew B.; Strynar, Mark J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Route, WT (reprint author), Natl Pk Serv, Great Lakes Inventory & Monitoring Network, Suite D,2800 Lake Shore Dr E, Ashland, WI 54806 USA. EM bill_route@nps.gov OI Russell, Robin/0000-0001-8726-7303 FU U.S. National Park Service Great Lakes Inventory and Monitoring Network; Minnesota Pollution Control Agency; Great Lakes Restoration Initiative; Donald Weesner Foundation FX Primary funding was provided by the U.S. National Park Service Great Lakes Inventory and Monitoring Network with additional support from the Minnesota Pollution Control Agency, the Great Lakes Restoration Initiative, and the Donald Weesner Foundation. A portion of this work was conducted as part of a Cooperative Research and Development Agreement between the USEPA and Agilent Technologies (#437-07). P. Bost, USEPA, and the 3M Corporation provided blind laboratory analyses, and G. Miller, Prairie Island Indian Community provided sample results and field assistance, as in-kind contributions. The Wisconsin State Laboratory of Hygiene was contracted as the primary analytical laboratory. We thank J. Campbell-Spickler and G. Renzullo for tree climbing and handling of nestlings, M. Martell for handling of nestlings, and many national park service staff and volunteers for assistance with data collection and logistics. We appreciate constructive comments on drafts of this manuscript by B. La Francois, D. VanderMeulen, L. Weller, and R. Erikson. The United States Environmental Protection Agency through its Office of Research and Development has reviewed this article and approved it for publication. Any use of trade, product, or firm names are for descriptive purposes only and do not imply endorsement by the U.S. Government. NR 51 TC 16 Z9 17 U1 6 U2 56 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 17 PY 2014 VL 48 IS 12 BP 6653 EP 6660 DI 10.1021/es501055d PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AJ4KU UT WOS:000337646000017 PM 24898913 ER PT J AU Lyon, BA Milsk, RY DeAngelo, AB Simmons, JE Moyer, MP Weinberg, HS AF Lyon, Bonnie A. Milsk, Rebecca Y. DeAngelo, Anthony B. Simmons, Jane Ellen Moyer, Mary P. Weinberg, Howard S. TI Integrated Chemical and Toxicological Investigation of UV-Chlorine/Chloramine Drinking Water Treatment SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID DISINFECTION BY-PRODUCTS; MAMMALIAN-CELL CYTOTOXICITY; NATURAL ORGANIC-MATTER; BLADDER-CANCER; DBP FORMATION; DEVELOPMENTAL TOXICITY; CYANOGEN CHLORIDE; MIXTURES RESEARCH; BENCH-SCALE; CHLORINATION AB As the use of alternative drinking water treatment increases, it is important to understand potential public health implications associated with these processes. The objective of this study was to evaluate the formation of disinfection byproducts (DBPs) and cytotoxicity of natural organic matter (NOM) concentrates treated with chlorine, chloramine, and medium pressure ultraviolet (UV) irradiation followed by chlorine or chloramine, with and without nitrate or iodide spiking. The use of concentrated NOM conserved volatile DBPs and allowed for direct analysis of the treated water. Treatment with UV prior to chlorine in ambient (unspiked) samples did not affect cytotoxicity as measured using an in vitro normal human colon cell (NCM460) assay, compared to chlorination alone when toxicity is expressed on the basis of dissolved organic carbon (DOC). Nitrate-spiked UV+chlorine treatment produced greater cytotoxicity than nitrate-spiked chlorine alone or ambient UV+chlorine samples, on both a DOC and total organic halogen basis. Samples treated with UV +chloramine were more cytotoxic than those treated with only chloramine using either dose metric. This study demonstrated the combination of cytotcodcity and DBP measurements for process evaluation in drinking water treatment. The results highlight the importance of dose metric when considering the relative toxicity of complex DBP mixtures formed under different disinfection scenarios. C1 [Lyon, Bonnie A.; Milsk, Rebecca Y.; Weinberg, Howard S.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [DeAngelo, Anthony B.; Simmons, Jane Ellen] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Moyer, Mary P.] INCELL Corp, San Antonio, TX 78249 USA. RP Weinberg, HS (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, 146A Rosenau Hall, Chapel Hill, NC 27599 USA. EM howard_weinberg@unc.edu OI Marion, Bonnie/0000-0001-9425-7840 FU Water Research Foundation [4303]; Royster Society of Fellows Dissertation Completion Fellowship from University of North Carolina at Chapel Hill (UNC); Gillings Dissertation Award from the University of North Carolina at Chapel Hill (UNC); U.S. Environmental Protection Agency FX This work was supported by Water Research Foundation Project 4303 as well as a Royster Society of Fellows Dissertation Completion Fellowship and Gillings Dissertation Award both from the University of North Carolina at Chapel Hill (UNC). Thanks to Dr. Eric Bair in the UNC Biostatistics department for help with statistics and Dr. Roland Kwitt of Kitware Inc., Carrboro, NC, USA for assistance with programming. The information in this document has been funded in part by the U.S. Environmental Protection Agency. NR 82 TC 11 Z9 11 U1 5 U2 113 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 17 PY 2014 VL 48 IS 12 BP 6743 EP 6753 DI 10.1021/es501412n PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AJ4KU UT WOS:000337646000028 PM 24840005 ER PT J AU Juhasz, AL Gancarz, D Herde, C McClure, S Scheckel, KG Smith, E AF Juhasz, Albert L. Gancarz, Dorota Herde, Carina McClure, Stuart Scheckel, Kirk G. Smith, Euan TI In Situ Formation of Pyromorphite Is Not Required for the Reduction of in Vivo Pb Relative Bioavailability in Contaminated Soils SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LEAD BIOAVAILABILITY; MANGANESE OXIDE; EXTRACTION TEST; IMMOBILIZATION; PHOSPHORUS; PHOSPHATE; EXPOSURE; SMELTER; CHLOROPYROMORPHITE; BIOACCESSIBILITY AB The effect of phosphate treatment on lead relative bioavailability (Pb RBA) was assessed in three distinct Pb-contaminated soils. Phosphoric acid (PA) or rock phosphate were added to smelter (PP2), nonferrous slag (SH15), and shooting range (SR01) impacted soils at a P:Pb molar ratio of 5:1. In all of the phosphate amended soils, Pb RBA decreased compared to that in untreated soils when assessed using an in vivo mouse model. Treatment effect ratios (i.e., the ratio of Pb RBA in treated soil divided by Pb RBA in untreated soil) ranged from 0.39 to 0.67, 0.48 to 0.90, and 0.03 to 0.19 for PP2, SH15, and SR01, respectively. The decrease in Pb RBA following phosphate amendment was attributed to the formation of poorly soluble Pb phosphates (i.e., chloropyromorphite, hydroxypyromorphite, and Pb phosphate) that were identified by X-ray absorption spectroscopy (XAS). However, a similar decrease in Pb RBA was also observed in untreated soils following the sequential gavage of phosphate amendments. This suggests that in vivo processes may also facilitate the formation of poorly soluble Pb phosphates, which decreases Pb absorption. Furthermore, XAS analysis of PA-treated PP2 indicated further in vivo changes in Pb speciation as it moved through the gastrointestinal tract, which resulted in the transformation of hydroxypyromorphite to chloropyromorphite. C1 [Juhasz, Albert L.; McClure, Stuart; Smith, Euan] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. [Gancarz, Dorota; Herde, Carina] South Australian Hlth & Med Res Inst, Gilles Plains, SA 5086, Australia. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA. RP Juhasz, AL (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. EM Albert.Juhasz@unisa.edu.au RI Juhasz, Albert/F-6600-2011; OI Juhasz, Albert/0000-0002-1164-4085; Scheckel, Kirk/0000-0001-9326-9241 FU Centre for Environmental Risk Assessment and Remediation, University of South Australia; South Australian Health and Medical Research Institute; EPA; Department of Energy; MRCAT FX The authors would like to acknowledge the support of the Centre for Environmental Risk Assessment and Remediation, University of South Australia, and the South Australian Health and Medical Research Institute for this research. Lead RBA studies were approved and conducted according to application 16/11 of the Institute of Medical and Veterinary Science Animal Ethics Committee. Although EPA staff contributed to this article, the research presented was not performed by, or funded by, the EPA and was not subject to the EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not reflect or represent the EPA's views or policies. MRCAT operations were supported by the Department of Energy and the MRCAT member institutions. NR 36 TC 10 Z9 12 U1 2 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 17 PY 2014 VL 48 IS 12 BP 7002 EP 7009 DI 10.1021/es500994u PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AJ4KU UT WOS:000337646000058 PM 24823360 ER PT J AU Sarwar, G Simon, H Xing, J Mathur, R AF Sarwar, Golam Simon, Heather Xing, Jia Mathur, Rohit TI Importance of tropospheric ClNO2 chemistry across the Northern Hemisphere SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID QUALITY CMAQ MODEL; EMISSIONS INVENTORY; CHLORINE ACTIVATION; CARBON BOND; VERSION 4.5; PARTICLES; PERFORMANCE; N2O5; PARAMETERIZATION; SYSTEM AB Laboratory and field experiments have revealed that uptake of dinitrogen pentoxide (N2O5) on aerosols containing chloride produces nitryl chloride (ClNO2) and nitric acid. We incorporate heterogeneous ClNO2 formation into the hemispheric Community Multiscale Air Quality model. This heterogeneous chemistry substantially enhances ClNO2 levels in several areas of the Northern Hemisphere and alters the composition of airborne reactive nitrogen, comprising more than 15% of monthly mean values in some areas. Model results suggest that this heterogeneous chemistry reduces monthly mean total nitrate by up to 25% and enhances monthly mean daily maximum 8 h ozone by up to 7.0 ppbv. The pathway also enhances hydroxyl radical by more than 20% in some locations which in turn increases sulfate and other secondary pollutants. The largest ClNO2 concentrations and impacts occur over China and Western Europe, two areas in which few relevant field measurements have been made. C1 [Sarwar, Golam; Xing, Jia; Mathur, Rohit] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Simon, Heather] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC USA. RP Sarwar, G (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM sarwar.golam@epa.gov RI xing, jia/O-1784-2014; simon, heather/E-4392-2011 OI simon, heather/0000-0001-7254-3360 NR 36 TC 20 Z9 20 U1 9 U2 47 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 16 PY 2014 VL 41 IS 11 BP 4050 EP 4058 DI 10.1002/2014GL059962 PG 9 WC Geosciences, Multidisciplinary SC Geology GA AL6YP UT WOS:000339280200049 ER PT J AU Kim, YH Tong, HY Daniels, M Boykin, E Krantz, QT McGee, J Hays, M Kovalcik, K Dye, JA Gilmour, MI AF Kim, Yong Ho Tong, Haiyan Daniels, Mary Boykin, Elizabeth Krantz, Q. Todd McGee, John Hays, Michael Kovalcik, Kasey Dye, Janice A. Gilmour, M. Ian TI Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices SO PARTICLE AND FIBRE TOXICOLOGY LA English DT Article DE Wildfire; Peat fire; Particulate matter; Lung inflammation; Cardiac perfusion; Lung tissue slices ID AIR-POLLUTION; TISSUE-SLICES; SMOKE EXPOSURE; CALIFORNIA WILDFIRES; FIRE EMISSIONS; NORTH-CAROLINA; FOREST-FIRES; RESPONSES; COARSE; ENDOTOXIN AB Background: Emissions from a large peat fire in North Carolina in 2008 were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger amounts of smoke and last longer than forest fires, however few studies have reported on their toxicity. Moreover, reliable alternatives to traditional animal toxicity testing are needed to reduce the number of animals required for hazard identification and risk assessments. Methods: Size-fractionated particulate matter (PM; ultrafine, fine, and coarse) were obtained from the peat fire while smoldering (ENCF-1) or when nearly extinguished (ENCF-4). Extracted samples were analyzed for chemical constituents and endotoxin content. Female CD-1 mice were exposed via oropharyngeal aspiration to 100 g/mouse, and assessed for relative changes in lung and systemic markers of injury and inflammation. At 24 h post-exposure, hearts were removed for ex vivo functional assessments and ischemic challenge. Lastly, 8 mm diameter lung slices from CD-1 mice were exposed (11 mu g) +/- co-treatment of PM with polymyxin B (PMB), an endotoxin-binding compound. Results: On an equi-mass basis, coarse ENCF-1 PM had the highest endotoxin content and elicited the greatest pro-inflammatory responses in the mice including: increases in bronchoalveolar lavage fluid protein, cytokines (IL-6, TNF-a, and MIP-2), neutrophils and intracellular reactive oxygen species (ROS) production. Exposure to fine or ultrafine particles from either period failed to elicit significant lung or systemic effects. In contrast, mice exposed to ENCF-1 ultrafine PM developed significantly decreased cardiac function and greater post-ischemia-associated myocardial infarction. Finally, similar exposures to mouse lung slices induced comparable patterns of cytokine production; and these responses were significantly attenuated by PMB. Conclusions: The findings suggest that exposure to coarse PM collected during a peat fire causes greater lung inflammation in association with endotoxin and ROS, whereas the ultrafine PM preferentially affected cardiac responses. In addition, lung tissue slices were shown to be a predictive, alternative assay to assess pro-inflammatory effects of PM of differing size and composition. Importantly, these toxicological findings were consistent with the cardiopulmonary health effects noted in epidemiologic reports from exposed populations. C1 [Kim, Yong Ho] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA. [Tong, Haiyan; Daniels, Mary; Boykin, Elizabeth; Krantz, Q. Todd; McGee, John; Dye, Janice A.; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Hays, Michael] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Kovalcik, Kasey] US EPA, Human Exposure Assessment Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM gilmour.ian@epa.gov RI Hays, Michael/E-6801-2013 OI Hays, Michael/0000-0002-4029-8660 FU EPA-UNC Toxicology Training Agreement [CR-83515201-0]; Curriculum in Toxicology, University of North Carolina at Chapel Hill FX We thank Debora Andrews, Judy Richards, Gaynelle McGee, and Richard Jaskot for technical assistance in toxicologic analyses; Dr. Wayne E. Cascio for valuable comments and Drs. Andrew Ghio and Stephen Gavett for their review of this manuscript. The project was supported by grant from the EPA-UNC Toxicology Training Agreement (CR-83515201-0), with the Curriculum in Toxicology, University of North Carolina at Chapel Hill. This paper has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that contents necessarily reflect the views and polices of Agency, nor does the mention of trade names or commercial products constitute endorsement or recommendation for use. NR 74 TC 12 Z9 13 U1 2 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-8977 J9 PART FIBRE TOXICOL JI Part. Fibre Toxicol. PD JUN 16 PY 2014 VL 11 AR 29 DI 10.1186/1743-8977-11-29 PG 17 WC Toxicology SC Toxicology GA AK5LJ UT WOS:000338465800001 PM 24934158 ER PT J AU Markovic, MZ VandenBoer, TC Baker, KR Kelly, JT Murphy, JG AF Markovic, M. Z. VandenBoer, T. C. Baker, K. R. Kelly, J. T. Murphy, J. G. TI Measurements and modeling of the inorganic chemical composition of fine particulate matter and associated precursor gases in California's San Joaquin Valley during CalNex 2010 SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article DE PM2; 5; ammonia; air quality; chemical transport modeling; nitric acid ID SECONDARY ORGANIC AEROSOL; PM10/PM2.5 AIR-QUALITY; MINERAL DUST AEROSOL; HETEROGENEOUS REACTION; UNITED-STATES; NITRIC-ACID; DISSOCIATION-CONSTANT; ATMOSPHERIC AMMONIA; TEMPORAL VARIATIONS; EMISSION INVENTORY AB A modified Ambient Ion Monitor-Ion Chromatograph was utilized to monitor the composition of water-soluble fine particulate matter (PM2.5) and precursor gases at the Bakersfield, CA, supersite during Research at the Nexus of Air Quality and Climate Change (CalNex) in May and June of 2010. The observations were used to investigate inorganic gas/particle partitioning, to derive an empirical relationship between ammonia emissions and temperature, and to assess the performance of the Community Multiscale Air Quality (CMAQ) model. The water-soluble PM2.5 maximized in the morning and in the evening because of gas/particle partitioning and possibly regional transport. Among the PM2.5 constituents, pNO3- was the dominant chemical species with campaign average mass loading of 0.80 mu gm-3, and the mass loadings of pNH4+ and pSO42- were 0.46 mu gm-3 and 0.53 mu gm-3, respectively. The observed HNO3 (g) levels had an average of 0.14ppb. Sub-ppb levels of SO2 (g) were measured, consistent with the absence of major emission sources in the region. Measured NH3 (g) had an average of 19.7ppb over the campaign and demonstrated a strong relationship with temperature. Observations of ammonia were used to derive an empirical enthalpy for volatilization of 30.8 +/- 2.1kJmol-1. The gas/particle partitioning of semivolatile PM2.5 composition was driven by meteorological factors and limited by total nitrate (TN) in this region. CMAQ model output exhibited significant biases in the predicted concentrations of pSO42-, NH3 (g), and TN. The largest model bias was in HNO3 (g), with an overprediction of an order of magnitude, which may be due to missing HNO3 (g) sinks such as reactive uptake on dust in the CMAQ framework. C1 [Markovic, M. Z.; VandenBoer, T. C.; Murphy, J. G.] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada. [Baker, K. R.; Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Murphy, JG (reprint author), Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 1A1, Canada. EM jmurphy@chem.utoronto.ca RI Murphy, Jennifer/C-2367-2011; Kelly, James/F-8135-2010; VandenBoer, Trevor/F-1032-2011 OI Kelly, James/0000-0001-6574-5714; VandenBoer, Trevor/0000-0001-8926-4237 FU California Air Resources Board (CARB) [08-316]; Canada Foundation for Innovation; Centre for Global Change Science at the University of Toronto; NSERC Alexander Graham Bell Doctoral Canadian Graduate Scholarship; University of Toronto FX The authors would like to thank John Karlik and University of California's Kern County Cooperative Extension staff for help and support during CalNex 2010 campaign. Bakersfield supersite infrastructure was financially supported by the California Air Resources Board (CARB, contract 08-316 to University of California Berkeley, PI's Ron C. Cohen and Allen H. Goldstein). Funding for instrumentation was provided by the Canada Foundation for Innovation. The authors also thank R.J. Weber for providing the wind, temperature, and relative humidity measurements, CARB for providing the long-term speciated measurements of PM2.5 mass loadings, and Jeff Geddes for the assistance with the data analysis. M.Z. Markovic would like to acknowledge Centre for Global Change Science at the University of Toronto for the funding to participate in the Calnex 2010 campaign. T. C. VandenBoer acknowledges funding to participate in the CalNex 2010 campaign provided through and NSERC Alexander Graham Bell Doctoral Canadian Graduate Scholarship and the University of Toronto for a Special Opportunity Travel Grant. K. Baker would like to thank Chris Misenis, Lara Reynolds, Allan Beidler, James Beidler, and Chris Allen. NR 65 TC 4 Z9 4 U1 2 U2 38 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JUN 16 PY 2014 VL 119 IS 11 BP 6853 EP 6866 DI 10.1002/2013JD021408 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AJ8RK UT WOS:000337974500037 ER PT J AU Janeczko, AK Walters, EB Schuldt, SJ Magnuson, ML Willison, SA Brown, LM Ruiz, ON Felker, DL Racz, L AF Janeczko, Allen K. Walters, Edward B. Schuldt, Steven J. Magnuson, Matthew L. Willison, Stuart A. Brown, Lisa M. Ruiz, Oscar N. Felker, Daniel L. Racz, LeeAnn TI Fate of malathion and a phosphonic acid in activated sludge with varying solids retention times SO WATER RESEARCH LA English DT Article DE Organophosphate; Malathion; Ethylmethylphosphonic acid; Activated sludge; Solids retention time ID SEQUENCING BATCH REACTOR; MEMBRANE BIOREACTOR; NITROSOMONAS-EUROPAEA; ORGANOPHOSPHORUS PESTICIDES; DEGRADATION-PRODUCTS; BIOLOGICAL TREATMENT; NITRIFYING BACTERIA; NITROGEN REMOVAL; TREATMENT PLANTS; CARBON-SOURCES AB This study examined the ability of activated sludge (AS) to sorb and biodegrade ethylmethylphosphonic acid (EMPA) and malathion, a degradation product and surrogate, respectively, for an organophosphate chemical warfare agent. Sorption equilibrium isotherm experiments indicate that sorption of EMPA and malathion to AS is negligible. EMPA at a concentration of 1 mg L-1 degraded by approximately 30% with apparent firstorder kinetics, possibly via co-metabolism from nitrification. Heterotrophic bacteria and abiotic mechanisms, however, are largely responsible for malathion degradation also with apparent first-order kinetics. EMPA did not inhibit chemical oxygen demand (COD) oxidation or nitrification activity, although malathion did appear to induce a stress response resulting in inhibition of COD oxidation. The study also included a 30-day experiment in which malathion, at a concentration of 5 mg L-1, was repeatedly fed to AS in bench-scale sequencing batch reactors (SBRs) operating at different solids retention times (SRTs). Peak malathion concentrations occurred at day 4.5, with the longer SATs yielding greater peak malathion concentrations. The AS reduced the malathion concentrations to nearly zero by day 10 for all SRTs, even when the malathion concentration in the influent increased to 20.8 mg L-1. The data suggest a biodegradation pathway for malathion involving an oxygenase. Phylogenetic analyses revealed that all samples had an abundance of Zoogloea, though there was greater bacterial diversity in the SBR with the SRT of 50 days. The SER with an SRT of 9.5 days had an apparent reduction in the diversity of the bacterial community. Published by Elsevier Ltd. C1 [Janeczko, Allen K.; Walters, Edward B.; Schuldt, Steven J.; Felker, Daniel L.; Racz, LeeAnn] US Air Force, Inst Technol, Dept Syst Engn & Management, Wright Patterson AFB, OH 45433 USA. [Magnuson, Matthew L.; Willison, Stuart A.] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. [Brown, Lisa M.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Ruiz, Oscar N.] US Air Force, Res Lab, Aerosp Syst Directorate, Fuels & Energy Branch, Wright Patterson AFB, OH 45433 USA. RP Racz, L (reprint author), US Air Force, Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. EM allen.janeczko.1@us.af.mil; edward.walters@us.af.mil; steven.schuldt@us.af.mil; magnuson.matthew@epa.gov; willison.stuart@epa.gov; lisa.brown@udri.udayton.edu; oscar.ruiz@us.af.mil; daniel.felker@us.af.mil; leeann.racz@us.af.mil OI Felker, Daniel/0000-0002-7196-3758 FU U.S. Environmental Protection Agency (USEPA), through its Office of Research and Development [EPA 92351601] FX The U.S. Environmental Protection Agency (USEPA), through its Office of Research and Development, performed, managed, funded, and/or collaborated in the research described herein through an interagency agreement, EPA 92351601. This content has been peer and administratively reviewed and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the USEPA. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States government. The views and opinions expressed herein do not necessarily state or reflect those of the United States government and shall not be used for advertising or product endorsement purposes. NR 73 TC 6 Z9 6 U1 2 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD JUN 15 PY 2014 VL 57 BP 127 EP 139 DI 10.1016/j.watres.2014.03.031 PG 13 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AI9OH UT WOS:000337261400013 PM 24709533 ER PT J AU Sakofsky, CJ Roberts, SA Malc, E Mieczkowski, PA Resnick, MA Gordenin, DA Malkova, A AF Sakofsky, Cynthia J. Roberts, Steven A. Malc, Ewa Mieczkowski, Piotr A. Resnick, Michael A. Gordenin, Dmitry A. Malkova, Anna TI Break-Induced Replication Is a Source of Mutation Clusters Underlying Kataegis SO CELL REPORTS LA English DT Article ID CONSERVATIVE DNA-SYNTHESIS; HALF-CROSSOVERS; HUMAN CANCERS; REPAIR; MUTAGENESIS; BUBBLE AB Clusters of simultaneousmultiple mutations can be a source of rapid change during carcinogenesis and evolution. Such mutation clusters have been recently shown to originate from DNA damage within long single-stranded DNA (ssDNA) formed at resected double-strand breaks and dysfunctional replication forks. Here, we identify double-strand break (DSB)-induced replication (BIR) as another powerful source of mutation clusters that formed in nearly half of wild-type yeast cells undergoing BIR in the presence of alkylating damage. Clustered mutations were primarily formed along the track of DNA synthesis and were frequently associated with additional breakage and rearrangements. Moreover, the base specificity, strand coordination, and strand bias of the mutation spectrum were consistent with mutations arising from damage in persistent ssDNA stretches within unconventional replication intermediates. Altogether, these features closely resemble kataegic events in cancers, suggesting that replication intermediates during BIR may be the most prominent source of mutation clusters across species. C1 [Sakofsky, Cynthia J.; Malkova, Anna] Univ Iowa, Coll Liberal Arts & Sci, Dept Biol, Iowa City, IA 52242 USA. [Roberts, Steven A.; Resnick, Michael A.; Gordenin, Dmitry A.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. [Malc, Ewa; Mieczkowski, Piotr A.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA. [Malc, Ewa; Mieczkowski, Piotr A.] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA. [Sakofsky, Cynthia J.; Malkova, Anna] IUPUI, Sch Sci, Dept Biol, Indianapolis, IN 46202 USA. RP Gordenin, DA (reprint author), Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. EM gordenin@niehs.nih.gov; anna-malkova@uiowa.edu OI Gordenin, Dmitry/0000-0002-8399-1836 FU NIH [GM084242, 5R01GM052319-17]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [ES065073]; NIH Pathway to Independence [K99ES022633-01]; Department of Biology at IUPUI FX This work was funded by NIH grants GM084242 (to A.M.) and 5R01GM052319-17 (to P.A.M.) and by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (project ES065073, to M.A.R). S.A.R. was supported by NIH Pathway to Independence Award K99ES022633-01. C.J.S. was supported in part by the Department of Biology at IUPUI. NR 27 TC 34 Z9 34 U1 0 U2 6 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD JUN 12 PY 2014 VL 7 IS 5 BP 1640 EP 1648 DI 10.1016/j.celrep.2014.04.053 PG 9 WC Cell Biology SC Cell Biology GA AK3LA UT WOS:000338324200028 PM 24882007 ER PT J AU Starr, JM Graham, SE Ross, DG Tornero-Velez, R Scollon, EJ DeVito, MJ Crofton, KM Wolansky, MJ Hughes, MF AF Starr, James M. Graham, Stephen E. Ross, David G. Tornero-Velez, Rogelio Scollon, Edward J. DeVito, Michael J. Crofton, Kevin M. Wolansky, Marcelo J. Hughes, Michael F. TI Environmentally relevant mixing ratios in cumulative assessments: A study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats SO TOXICOLOGY LA English DT Article DE Pyrethroids; Pyrethroid metabolites; Toxicokinetics; Half-life ID HUMAN DOSE-EXCRETION; IN-VITRO METABOLISM; 3-PHENOXYBENZOIC ACID; HYDROLYTIC METABOLISM; INSECTICIDES; DELTAMETHRIN; URINE; TOXICOKINETICS; PERMETHRIN; EXPOSURE AB National surveys of United States households and child care centers have demonstrated that pyrethroids are widely distributed in indoor habited dwellings and this suggests that co-exposure to multiple pyrethroids occurs in nonoccupational settings. The purpose of this research was to use an environmentally relevant mixture of pyrethroids to assess their cumulative effect on motor activity and develop kinetic profiles for these pyrethroids and their hydrolytic metabolites in brain and blood of rats. Rats were dosed orally at one of two levels (1.5x or 5.0x the calculated dose that decreases rat motor activity by 30%) with a mixture of cypermethrin, deltamethrin, esfenvalerate, cis-/trans-permethrin, and p-cyfluthrin in corn oil. At 1, 2, 4, 8, or 24h after dosing, the motor activity of each animal was assessed and the animals sacrificed. Concentrations of pyrethroids in brain and blood, and the following metabolites: cis/trans-dichlorovinyl-dimethylcyclopropane-carboxylic acid, 3-phenoxybenzoic acid, 3-phenoxybenzyl alcohol, 4-fluoro-3-phenoxybenzoic acid, and cis-dibromovinyl-dimethylcyclopropane-carboxylic acid were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Using this pyrethroid mixture in rats, the results suggest there is greater metabolism of trans-permethrin prior to entering the systemic circulatory system. All pyrethroids had tissue half-lives (tip) of less than 5 h, excepting esfenvalerate in brain. At early time points, relative pyrethroid brain concentrations approximated their dose mixture proportions and a sigmoidal E. model described the relationship between motor activity decrease and total pyrethroid brain concentration. In blood, the tip's of the cyclopropane metabolites were longer than the phenoxybenzoic metabolites. However, relative to their respective precursors, concentrations of the phenoxybenzoic acids were much higher than concentrations of the cyclopropane metabolites. Brain concentrations of all metabolites were low relative to blood concentrations. This implies limited metabolite penetration of the blood-brain barrier and little metabolite formation within the brain. In conclusion: toxicokinetic differences between the pyrethroids did not appear to be important determinants of their relative potency and their effect on motor activity was consistent with a pyrethroid dose additive model. Published by Elsevier Ireland Ltd. C1 [Starr, James M.; Tornero-Velez, Rogelio] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Graham, Stephen E.] US EPA, Off Air Qual Planning & Stand, Hlth & Environm Impacts Div, Res Triangle Pk, NC 27711 USA. [Ross, David G.; Scollon, Edward J.; DeVito, Michael J.; Crofton, Kevin M.; Wolansky, Marcelo J.; Hughes, Michael F.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Starr, JM (reprint author), US EPA, MD D205-05,109 TW Alexander Dr RTP, Res Triangle Pk, NC 27711 USA. EM starr.james@epa.gov RI Crofton, Kevin/J-4798-2015 OI Crofton, Kevin/0000-0003-1749-9971 FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. NR 45 TC 6 Z9 6 U1 6 U2 44 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JUN 5 PY 2014 VL 320 BP 15 EP 24 DI 10.1016/j.tox.2014.02.016 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AI2UD UT WOS:000336712700003 PM 24631210 ER PT J AU Karambelas, A Pye, HOT Budisulistiorini, SH Surratt, JD Pinder, RW AF Karambelas, Alexandra Pye, Havala O. T. Budisulistiorini, Sri H. Surratt, Jason D. Pinder, Robert W. TI Contribution of Isoprene Epoxydiol to Urban Organic Aerosol: Evidence from Modeling and Measurements SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID REGIONAL AIR-QUALITY; SOUTHEASTERN US; UNITED-STATES; ACID; PHOTOOXIDATION; EMISSIONS; EPOXIDES; PRODUCTS; MARKERS AB In a region heavily influenced by anthropogenic and biogenic atmospheric emissions, recent field measurements have attributed one-third of urban organic aerosol by mass to isoprene epoxydiols (IEPOX). These aerosols arise from the gas-phase oxidation of isoprene, the formation of IEPOX, the reactive uptake of IEPOX by particles, and finally the formation of new compounds in the aerosol phase. Using a continental-scale chemical transport model, we find a strong temporal correspondence between the simulated formation of IEPOX-derived organic aerosol and these measurements. However, because only a subset of isoprene-derived aerosol compounds have been specifically identified in laboratory studies, our simulation of known IEPOX-derived organic aerosol compounds predicts a mass 10-fold lower than the field measurements, despite abundant gas-phase IEPOX. Sensitivity studies suggest that increasing the effective IEPOX uptake coefficient and including aerosol-phase reactions that lead to the addition of functional groups could increase the simulated IEPOX-derived aerosol mass and account for the difference between the field measurements and modeling results. C1 [Karambelas, Alexandra; Pye, Havala O. T.; Pinder, Robert W.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Budisulistiorini, Sri H.; Surratt, Jason D.] Univ N Carolina, Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. RP Pinder, RW (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM pinder.rob@epa.gov RI Surratt, Jason/D-3611-2009; Vaytsehovska, Oksana/D-6114-2016; Pye, Havala/F-5392-2012 OI Surratt, Jason/0000-0002-6833-1450; Vaytsehovska, Oksana/0000-0002-2313-033X; Pye, Havala/0000-0002-2014-2140 FU U.S. Environmental Protection Agency's Air, Climate, and Energy Program; Oak Ridge Institute for Science Education; NASA Applied Sciences Program through the NASA Air Quality Applied Sciences Team (AQAST) FX This work is supported by the U.S. Environmental Protection Agency's Air, Climate, and Energy Program and the Oak Ridge Institute for Science Education. A.K. acknowledges support from the NASA Applied Sciences Program through the NASA Air Quality Applied Sciences Team (AQAST). The group at the University of North Carolina at Chapel Hill thanks the Electric Power Research Institute (EPRI) for support in collecting the ACSM data set in downtown Atlanta, GA. NR 33 TC 14 Z9 14 U1 2 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD JUN PY 2014 VL 1 IS 6 BP 278 EP 283 DI 10.1021/ez5001353 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CD1JM UT WOS:000350831200002 ER PT J AU Silva, RG Nadagouda, MN Patterson, CL Panguluri, S Luxton, TP Sahle-Demessie, E Impellitteri, CA AF Silva, R. G. Nadagouda, M. N. Patterson, C. L. Panguluri, Srinivas Luxton, T. P. Sahle-Demessie, E. Impellitteri, C. A. TI Polymorph-dependent titanium dioxide nanoparticle dissolution in acidic and alkali digestions SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID OPTICAL-EMISSION-SPECTROMETRY; ENVIRONMENTAL-SAMPLES; PHASE-STABILITY; ICP-MS; SOIL; PHOTOCATALYSIS; SPECTROSCOPY; ANATASE; FUSION; RUTILE AB Multiple polymorphs (anatase, brookite and rutile) of titanium dioxide nanoparticles (TiO2-NPs) with variable structures were quantified in environmental matrices via microwave-based hydrofluoric (HF) and nitric (HNO3) mixed acid digestion and muffle furnace (MF)-based potassium hydroxide (KOH) fusion. The environmental matrices included stream bed sediments, kaolinite and bentonite. The percentage of titanium (Ti) recovered from the mixed acid digestion was not statistically different from KOH fusion when anatase and brookite TiO2-NPs were blended in all three environmental matrices. However, the percentage of Ti recovery of rutile TiO2-polymorph from the samples digested using the mixed acid digestion method was significantly lower [23 (+/- 5), 12 (+/- 6), 11 (+/- 0.6)] than those digested using KOH fusion method [74 (+/- 4), 53 (+/- 7), 75 (+/- 2)]. The recovery percent values reported are for Ti in sediment, kaolinite, and bentonite matrices, respectively. Exposing the TiO2-NP spiked samples to elevated heat and pressure reduced the recovery of Ti from all three polymorphs via mixed acid digestion. In contrast, Ti recoveries from KOH fusion improved after heat and pressure treatment. A narrowing of the X-ray diffraction (XRD) peaks for anatase and brookite after heat and pressure treatment indicated an increase in the aggregation or particle interaction of the TiO2-NPs. The XRD peaks for rutile TiO2-NP polymorph was similar before and after heat and pressure treatment. In summary, regardless of the selected environmental matrix type, the mixed acid digestibility of TiO2-NPs is polymorph-dependent; whereas, the KOH-fusion digestibility is polymorph independent. Therefore, when analyzing environmental samples containing TiO2-NPs with unknown polymorphs, a KOH-fusion digestion method is recommended for yielding consistent results. C1 [Silva, R. G.; Panguluri, Srinivas] US EPA, CB&I Fed Serv LLC, Test & Evaluat Facil, Cincinnati, OH 45204 USA. [Nadagouda, M. N.; Patterson, C. L.; Luxton, T. P.; Sahle-Demessie, E.; Impellitteri, C. A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Silva, RG (reprint author), US EPA, CB&I Fed Serv LLC, Test & Evaluat Facil, 1600 Gest St, Cincinnati, OH 45204 USA. EM Silva.Gune@epa.gov NR 32 TC 4 Z9 4 U1 3 U2 18 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON-SCI NANO JI Environ.-Sci. Nano PD JUN PY 2014 VL 1 IS 3 BP 284 EP 292 DI 10.1039/c3en00103b PG 9 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA AZ1AL UT WOS:000347972700008 ER PT J AU Hoque, YM Raj, C Hantush, MM Chaubey, I Govindaraju, RS AF Hoque, Yamen M. Raj, Cibin Hantush, Mohamed M. Chaubey, Indrajeet Govindaraju, Rao S. TI How Do Land-Use and Climate Change Affect Watershed Health? A Scenario-Based Analysis SO WATER QUALITY EXPOSURE AND HEALTH LA English DT Article DE Climate change; Land use; Watershed; Water quality; Biofuel crops; Reliability; Resilience; Vulnerability ID GROUNDWATER RECHARGE; POTENTIAL IMPACTS; SURFACE-WATER; UNITED-STATES; QUALITY; RELIABILITY; RIVER; RESILIENCE; CATCHMENT; CHINA AB With the growing emphasis on biofuel crops and potential impacts of climate variability and change, there is a need to quantify their effects on hydrological processes for developing watershed management plans. Environmental consequences are currently estimated by utilizing computer models such as Soil and Water Assessment Tool (SWAT) to simulate watershed hydrology under projected climate and land-use scenarios to assess the effect on water quantity and/or quality. Such studies have largely been deterministic in nature, with the focus being on whether hydrologic variables such as runoff, sediment and/or nutrient loads increase or decrease from the baseline case under projected scenarios. However, studying how these changes would affect watershed health in a risk-based framework has not been attempted. In this study, impacts of several projected land-use and climate change scenarios on the health of the Wildcat Creek watershed in Indiana have been assessed through three risk indicators, namely reliability-resilience-vulnerability (R-R-V). Results indicate that cultivation of biofuel crops such as Miscanthus and switchgrass has the potential to improve risk indicator values with respect to sediment, total N and total P. Climate change scenarios that involved rising precipitation levels were found to negatively impact watershed health indicators. Trends of water quality constituents under risk-based watershed health assessment revealed nuances not readily apparent from deterministic assessments alone. For example, while biofuel crop cultivation reduced total N loads under all hypothetical land-use scenarios examined in this study, watershed vulnerability in terms of total N also rose in some of those scenarios. Risk-based analyses coupled with deterministic methods are needed for a more comprehensive assessment of the health of a watershed under projected scenarios. C1 [Hoque, Yamen M.; Govindaraju, Rao S.] Purdue Univ, Dept Civil Engn, W Lafayette, IN 47907 USA. [Raj, Cibin; Chaubey, Indrajeet] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA. [Hantush, Mohamed M.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Hoque, YM (reprint author), Purdue Univ, Dept Civil Engn, W Lafayette, IN 47907 USA. EM yhoque@purdue.edu FU U.S. Environmental Protection Agency through its Office of Research and Development; EPA [EP-C-11-006] FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under EPA Contract # EP-C-11-006. It has not been subjected to Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. NR 48 TC 3 Z9 3 U1 13 U2 43 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1876-1658 EI 1876-1666 J9 WATER QUAL EXPOS HEA JI Water Qual. Expos. Health PD JUN PY 2014 VL 6 IS 1-2 SI SI BP 19 EP 33 DI 10.1007/s12403-013-0102-6 PG 15 WC Water Resources SC Water Resources GA AT2KH UT WOS:000344763000003 ER PT J AU Chang, NB Vannah, B Yang, YJ AF Chang, Ni-Bin Vannah, Benjamin Yang, Y. Jeffrey TI Comparative Sensor Fusion Between Hyperspectral and Multispectral Satellite Sensors for Monitoring Microcystin Distribution in Lake Erie SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Harmful algal bloom; image fusion; machine learning; microcystin; remote sensing ID LANDSAT SURFACE REFLECTANCE; ATMOSPHERIC CORRECTION; CYANOBACTERIAL BLOOMS AB Urban growth and agricultural production have caused an influx of nutrients into Lake Erie, leading to eutrophication in the water body. These conditions result in the formation of algal blooms, some of which are toxic due to the presence of Microcystis (a cyanobacteria), which produces the hepatotoxin microcystin. The hepatotoxin microcystin threatens human health and the ecosystem, and it is a concern for water treatment plants using the lake water as a tap water source. This study demonstrates the prototype of a near real-time early warning system using integrated data fusion and mining (IDFM) techniques with the aid of both hyperspectral (MERIS) and multispectral (MODIS and Landsat) satellite sensors to determine spatiotemporal microcystin concentrations in Lake Erie. In the proposed IDFM, the MODIS images with high temporal resolution are fused with the MERIS and Landsat images with higher spatial resolution to create synthetic images on a daily basis. The spatiotemporal distributions of microcystin within western Lake Erie were then reconstructed using the band data from the fused products with machine learning or data mining techniques such as genetic programming (GP) models. The performance of the data mining models derived using fused hyperspectral and fused multispectral sensor data are quantified using four statistical indices. These data mining models were further compared with traditional two-band models in terms of microcystin prediction accuracy. This study confirmed that GP models outperformed traditional two-band models, and additional spectral reflectance data offered by hyperspectral sensors produces a noticeable increase in the prediction accuracy especially in the range of low microcystin concentrations. C1 [Chang, Ni-Bin; Vannah, Benjamin] Univ Cent Florida, Dept Civil Environm & Construct Engn, Orlando, FL 32816 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Chang, NB (reprint author), Univ Cent Florida, Dept Civil Environm & Construct Engn, Orlando, FL 32816 USA. EM nchang@ucf.edu; benvannah@gmail.com; Yang.Jeff@epamail.epa.gov FU EPA [EP-C-11-006] FX This work is a part of U.S. EPA Water Resources Adaptation Program (WRAP) supported by EPA contract under Grant EP-C-11-006. This paper has been subjected to the administrative review by EPA and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 37 TC 6 Z9 6 U1 3 U2 32 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD JUN PY 2014 VL 7 IS 6 SI SI BP 2426 EP 2442 DI 10.1109/JSTARS.2014.2329913 PG 17 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA AN5HK UT WOS:000340621200048 ER PT J AU Mayer, PM Dwire, KA Okay, JA Vidon, PG AF Mayer, Paul M. Dwire, Kathleen A. Okay, Judith A. Vidon, Philippe G. TI FEATURED COLLECTION INTRODUCTION: RIPARIAN ECOSYSTEMS AND BUFFERS II SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Editorial Material C1 [Mayer, Paul M.] US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97333 USA. [Dwire, Kathleen A.] US Forest Serv, Rocky Mt Res Stn, USDA, Ft Collins, CO 80526 USA. [Okay, Judith A.] J&J Okay Consulting Inc, Solomons, MD 20688 USA. [Vidon, Philippe G.] SUNY Coll Environm Sci & Forestry, Dept Forest & Nat Resources Management, Syracuse, NY 13210 USA. RP Mayer, PM (reprint author), US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97333 USA. EM mayer.paul@epa.gov OI Mayer, Paul/0000-0002-8550-1386 NR 17 TC 0 Z9 0 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2014 VL 50 IS 3 BP 529 EP 532 DI 10.1111/jawr.12212 PG 4 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AN3CQ UT WOS:000340462900001 ER PT J AU Kaushal, SS Mayer, PM Vidon, PG Smith, RM Pennino, MJ Newcomer, TA Duan, SW Welty, C Belt, KT AF Kaushal, Sujay S. Mayer, Paul M. Vidon, Philippe G. Smith, Rose M. Pennino, Michael J. Newcomer, Tamara A. Duan, Shuiwang Welty, Claire Belt, Kenneth T. TI LAND USE AND CLIMATE VARIABILITY AMPLIFY CARBON, NUTRIENT, AND CONTAMINANT PULSES: A REVIEW WITH MANAGEMENT IMPLICATIONS SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE eutrophication; water quality; hypoxia; nonpoint source pollution; methane; nitrous oxide; carbon dioxide; restoration; wetlands; best management practices ID NITROUS-OXIDE EMISSIONS; DISSOLVED ORGANIC-CARBON; GREENHOUSE-GAS EMISSIONS; FLOW CONSTRUCTED WETLANDS; NONPOINT-SOURCE POLLUTION; CREATED RIPARIAN MARSHES; COASTAL-PLAIN WATERSHEDS; LOWER MISSISSIPPI RIVER; SPRING-FED RIVER; GULF-OF-MEXICO AB Nonpoint source pollution from agriculture and urbanization is increasing globally at the same time climate extremes have increased in frequency and intensity. We review > 200 studies of hydrologic and gaseous fluxes and show how the interaction between land use and climate variability alters magnitude and frequency of carbon, nutrient, and greenhouse gas pulses in watersheds. Agricultural and urban watersheds respond similarly to climate variability due to headwater alteration and loss of ecosystem services to buffer runoff and temperature changes. Organic carbon concentrations/exports increase and organic carbon quality changes with runoff. Nitrogen and phosphorus exports increase during floods (sometimes by an order of magnitude) and decrease during droughts. Relationships between annual runoff and nitrogen and phosphorus exports differ across land use. CH4 and N2O pulses in riparian zones/floodplains predominantly increase with: flooding, warming, low oxygen, nutrient enrichment, and organic carbon. CH4, N2O, and CO2 pulses in streams/rivers increase due to similar factors but effects of floods are less known compared to base flow/droughts. Emerging questions include: (1) What factors influence lag times of contaminant pulses in response to extreme events? (2) What drives resistance/resilience to hydrologic and gaseous pulses? We conclude with eight recommendations for managing watershed pulses in response to interactive effects of land use and climate change. C1 [Kaushal, Sujay S.; Smith, Rose M.; Newcomer, Tamara A.; Duan, Shuiwang] Univ Maryland, Dept Geol, College Pk, MD 20740 USA. [Kaushal, Sujay S.; Smith, Rose M.; Newcomer, Tamara A.; Duan, Shuiwang] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA. [Mayer, Paul M.] US EPA, Ecol Effects Branch, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. [Vidon, Philippe G.] SUNY Coll Environm Sci & Forestry, Dept Forest & Nat Resources Management, Syracuse, NY 13210 USA. [Pennino, Michael J.] Univ Maryland Baltimore Cty, Marine Estuarine Environm Sci Grad Program, Baltimore, MD 21250 USA. [Welty, Claire] Univ Maryland Baltimore Cty, Ctr Urban Environm Res & Educ, Baltimore, MD 21250 USA. [Welty, Claire] Univ Maryland Baltimore Cty, Dept Chem Biochem & Environm Engn, Baltimore, MD 21250 USA. [Belt, Kenneth T.] US Forest Serv, No Res Stn, USDA, Baltimore, MD 21228 USA. RP Kaushal, SS (reprint author), Univ Maryland, Dept Geol, College Pk, MD 20740 USA. EM skaushal@umd.edu RI Kaushal, Sujay/G-1062-2013; Newcomer Johnson, Tamara/D-1045-2013; OI Kaushal, Sujay/0000-0003-0834-9189; Newcomer Johnson, Tamara/0000-0002-2496-7641; Mayer, Paul/0000-0002-8550-1386 FU NASA [NASA NNX11AM28G]; Maryland Sea Grant [SA7528085-U, R/WS-2, NA05OAR4171042]; USGS [IWRRC 06HQGR0084 (104B), USGS-NIWR 08HQGR0052 (104 G)]; EPA NNEMS [2010-308]; Indiana University-Purdue University; Indianapolis RSGF; Mirsky Fellowship FX NSF: LTER DEB-0423476 and DEB-1027188, DEB-0948944, DBI 0640300, CBET-0854307, CBET-1058038, NASA grant NASA NNX11AM28G, and Maryland Sea Grant Awards SA7528085-U, R/WS-2, and NA05OAR4171042. Partial support was provided by grant/cooperative agreement numbers # IWRRC 06HQGR0084 (104B) and USGS-NIWR 08HQGR0052 (104 G) to P. Vidon from USGS and EPA NNEMS Award 2010-308 to T. Newcomer. Additional funding was provided by an Indiana University-Purdue University, Indianapolis RSGF grant to P. Vidon, and a Mirsky Fellowship to P. E. Cuadra. Bill Stack provided helpful suggestions. The information presented herein is solely the responsibility of the authors and does not necessarily represent the official views of the USGS. This manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 216 TC 24 Z9 24 U1 21 U2 156 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2014 VL 50 IS 3 BP 585 EP 614 DI 10.1111/jawr.12204 PG 30 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AN3CQ UT WOS:000340462900005 ER PT J AU Lazar, JG Gold, AJ Addy, K Mayer, PM Forshay, KJ Groffman, PM AF Lazar, Julia G. Gold, Arthur J. Addy, Kelly Mayer, Paul M. Forshay, Kenneth J. Groffman, Peter M. TI INSTREAM LARGE WOOD: DENITRIFICATION HOTSPOTS WITH LOW N2O PRODUCTION SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE riparian ecology; aquatic ecology; biogeochemistry; rivers/streams; nutrients; nitrous oxide; non-point source pollution; algae; biofilm ID STABLE-ISOTOPE RATIOS; NITRATE REMOVAL; RIPARIAN ZONES; ESTUARINE SEDIMENTS; RIVER BIOFILMS; FOREST STREAM; WATER-QUALITY; HOT MOMENTS; NITROGEN; CARBON AB We examined the effect of instream large wood on denitrification capacity in two contrasting, lower order streams - one that drains an agricultural watershed with no riparian forest and minimal stores of instream large wood and another that drains a forested watershed with an extensive riparian forest and abundant instream large wood. We incubated two types of wood substrates (fresh wood blocks and extant streambed wood) and an artificial stone substrate for nine weeks in each stream. After in situ incubation, we collected the substrates and their attached biofilms and established laboratory-based mesocosm assays with stream water amended with N-15-labeled nitrate-N. Wood substrates at the forested site had significantly higher denitrification than wood substrates from the agricultural site and artificial stone substrates from either site. Nitrate-N removal rates were markedly higher on woody substrates compared to artificial stones at both sites. Nitrate-N removal rates were significantly correlated with biofilm biomass. Denitrification capacity accounted for only a portion of nitrate-N removal observed within the mesocosms in both the wood controls and instream substrates. N-2 accounted for 99.7% of total denitrification. Restoration practices that generate large wood in streams should be encouraged for N removal and do not appear to generate high risks of instream N2O generation. C1 [Lazar, Julia G.; Gold, Arthur J.; Addy, Kelly] Univ Rhode Isl, Coastal Inst, Dept Nat Resources Sci, Kingston, RI 02881 USA. [Mayer, Paul M.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97330 USA. [Forshay, Kenneth J.] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA. [Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. RP Lazar, JG (reprint author), Univ Rhode Isl, Coastal Inst, Dept Nat Resources Sci, 1 Greenhouse Rd, Kingston, RI 02881 USA. EM agold@uri.edu RI Forshay, Ken/N-4068-2014; Forshay, Kenneth/P-3649-2015; OI Forshay, Ken/0000-0002-2867-8492; Forshay, Kenneth/0000-0002-2867-8492; Mayer, Paul/0000-0002-8550-1386 FU USDA-NRCS; RI Agricultural Experiment Station [5400]; NSF EPSCoR [0554548] FX We thank Bob Walter and Dorothy Merritts, Franklin and Marshall College for assistance and support; URI Coastal Fellows Mat Lautenberger, Lauren Creamer, Aimee Welch, and Molly Welsh for their help and support; and anonymous reviewers for insightful comments on drafts of this manuscript. This project was supported by grants from USDA-NRCS, RI Agricultural Experiment Station (contribution no. 5400), and NSF EPSCoR Grant No. 0554548. The research has not been subjected to U.S. Environmental Protection Agency review and, therefore, does not necessarily reflect the views of any of the funding agencies, and no official endorsement should be inferred. NR 56 TC 3 Z9 3 U1 7 U2 40 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2014 VL 50 IS 3 BP 615 EP 625 DI 10.1111/jawr.12202 PG 11 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AN3CQ UT WOS:000340462900006 ER PT J AU Patil, SD Wigington, PJ Leibowitz, SG Comeleo, RL AF Patil, Sopan D. Wigington, Parker J., Jr. Leibowitz, Scott G. Comeleo, Randy L. TI USE OF HYDROLOGIC LANDSCAPE CLASSIFICATION TO DIAGNOSE STREAMFLOW PREDICTABILITY IN OREGON SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE surface water hydrology; simulation; streamflow; watersheds; rivers/streams ID FLOOD FREQUENCY-ANALYSIS; RAINFALL-RUNOFF MODEL; CONTERMINOUS UNITED-STATES; WATER-BALANCE; DOWNWARD APPROACH; UNGAUGED CATCHMENTS; GROUNDWATER MODEL; LAND-SURFACE; SNOW COVER; CLIMATE AB We implement a spatially lumped hydrologic model to predict daily streamflow at 88 catchments within the state of Oregon and analyze its performance using the Oregon Hydrologic Landscape (OHL) classification. OHL is used to identify the physio-climatic conditions that favor high (or low) streamflow predictability. High prediction catchments (Nash-Sutcliffe efficiency of root Q (NS) > 0.75) are mainly classified as rain dominated with very wet climate, low aquifer permeability, and low to medium soil permeability. Most of them are located west of the Cascade Mountain Range. Conversely, most low prediction catchments (NS < 0.6) are classified as snow-dominated with high aquifer permeability and medium to high soil permeability. They are mainly located in the volcano-influenced High Cascades region. Using a subset of 36 catchments, we further test if class-specific model parameters can be developed to predict at ungauged catchments. In most catchments, OHL class-specific parameters provide predictions that are on par with individually calibrated parameters (NS decline < 10%). However, large NS declines are observed in OHL classes where predictability is not high enough. Results suggest higher uncertainty in rain-to-snow transition of precipitation phase and external gains/losses of deep groundwater are major factors for low prediction in Oregon. Moreover, regionalized estimation of model parameters is more useful in regions where conditions favor good streamflow predictability. C1 [Patil, Sopan D.] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor LL57 2UW, Gwynedd, Wales. [Wigington, Parker J., Jr.; Leibowitz, Scott G.; Comeleo, Randy L.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97330 USA. RP Patil, SD (reprint author), Bangor Univ, Sch Environm Nat Resources & Geog, Deiniol Rd, Bangor LL57 2UW, Gwynedd, Wales. EM s.d.patil@bangor.ac.uk RI Patil, Sopan/E-8497-2011 OI Patil, Sopan/0000-0002-8575-5220 FU ORISE; U.S. Environmental Protection Agency FX We are thankful to C. Rhett Jackson, Bob Ozretich, and three anonymous reviewers for valuable comments and suggestions that have greatly improved this paper. The first author (Patil) was supported by ORISE postdoctoral fellowship for the duration of this study. The information in this document has been funded entirely by the U.S. Environmental Protection Agency. This manuscript has been subjected to Agency review and has been approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 72 TC 8 Z9 8 U1 2 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2014 VL 50 IS 3 BP 762 EP 776 DI 10.1111/jawr.12143 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AN3CQ UT WOS:000340462900016 ER PT J AU Nichols, JL Gladwell, W Verhein, KC Cho, HY Wess, J Suzuki, O Wiltshire, T Kleeberger, SR AF Nichols, Jennifer L. Gladwell, Wesley Verhein, Kirsten C. Cho, Hye-Youn Wess, Jurgen Suzuki, Oscar Wiltshire, Tim Kleeberger, Steven R. TI Genome-wide association mapping of acute lung injury in neonatal inbred mice SO FASEB JOURNAL LA English DT Article DE bronchopulmonary dysplasia; inflammation; quantitative trait locus; cholinergic receptor; muscarinic 2; cardiac ID NONNEURONAL CHOLINERGIC SYSTEM; BRONCHOPULMONARY DYSPLASIA; RECEPTOR STIMULATION; IN-VITRO; INFLAMMATION; DISEASE; STRAIN; DELETION; AIRWAYS; SUSCEPTIBILITY AB Reactive oxygen species (ROS) contribute to the pathogenesis of many acute and chronic pulmonary disorders, including bronchopulmonary dysplasia (BPD), a respiratory condition that affects preterm infants. However, the mechanisms of susceptibility to oxidant stress in neonatal lungs are not completely understood. We evaluated the role of genetic background in response to oxidant stress in the neonatal lung by exposing mice from 36 inbred strains to hyperoxia (95% O-2) for 72 h after birth. Hyperoxia-induced lung injury was evaluated by using bronchoalveolar lavage fluid (BALF) analysis and pathology. Statistically significant interstrain variation was found for BALF inflammatory cells and protein (heritability estimates range: 33.6-55.7%). Genome-wide association mapping using injury phenotypes identified quantitative trait loci (QTLs) on chromosomes 1, 2, 4, 6, and 7. Comparative mapping of the chromosome 6 QTLs identified Chrm2 (cholinergic receptor, muscarinic 2, cardiac) as a candidate susceptibility gene, and mouse strains with a nonsynonymous coding single-nucleotide polymorphism (SNP) in Chrm2 that causes an amino acid substitution (P265L) had significantly reduced hyperoxia-induced inflammation compared to strains without the SNP. Further, hyperoxia-induced lung injury was significantly reduced in neonatal mice with targeted deletion of Chrm2, relative to wild-type controls. This study has important implications for understanding the mechanisms of oxidative lung injury in neonates. C1 [Nichols, Jennifer L.; Gladwell, Wesley; Verhein, Kirsten C.; Cho, Hye-Youn; Kleeberger, Steven R.] Natl Inst Environm Hlth Sci, US Natl Inst Hlth, Lab Resp Biol, Res Triangle Pk, NC USA. [Nichols, Jennifer L.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Curriculum Toxicol, Chapel Hill, NC USA. [Suzuki, Oscar] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC USA. [Wess, Jurgen] Natl Inst Diabet & Digest & Kidney Dis, Bioorgan Chem Lab, US Natl Inst Hlth, Bethesda, MD USA. RP Kleeberger, SR (reprint author), NIEHS, 111 T W Alexander Dr,Bldg 101,MD 201, Res Triangle Pk, NC 27709 USA. EM kleeber1@niehs.nih.gov FU NIEHS, National Institutes of Health, U.S. Department of Health and Human Services FX The authors thank L. M. DeGraff [National Institute of Environmental Health Sciences (NIEHS)], L. Perrow (NIEHS), and H. Price (Alion Science and Technology, McLean, VA, USA) for assistance with animal breeding and exposures; the NIEHS Histology Core for tissue processing and staining; and Drs. D. Cook and M. Fessler for critical review of the manuscript. This work was supported by a Director's Challenge Program and the Intramural Research Program, NIEHS, National Institutes of Health, U.S. Department of Health and Human Services. Author contributions: J.L.N., W.G., H.-Y.C., and S.R.K. conceived and designed the experiments; J.L.N., W.G., and K.C.V. performed the experiments; J.L.N., O.S., J.W., T.W., and K.C.V. analyzed the data; J.L.N. and S.R.K. wrote the paper; J.W. contributed animals. NR 56 TC 6 Z9 6 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD JUN PY 2014 VL 28 IS 6 BP 2538 EP 2550 DI 10.1096/fj.13-247221 PG 13 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AM5GA UT WOS:000339883600014 PM 24571919 ER PT J AU Green, OO Garmestani, AS Hopton, ME Heberling, MT AF Green, Olivia Odom Garmestani, Ahjond S. Hopton, Matthew E. Heberling, Matthew T. TI A Multi-Scalar Examination of Law for Sustainable Ecosystems SO SUSTAINABILITY LA English DT Article DE resilience; environmental law; coral reef ecosystems; sustainability ID PUBLIC TRUST DOCTRINE; CORAL-REEFS; FUNCTIONAL DIVERSITY; SOUTH-PACIFIC; RESILIENCE; MANAGEMENT; BIODIVERSITY; SCALE; REDUNDANCY; STABILITY AB The loss of resilience in social-ecological systems has the capacity to decrease essential ecosystem services, posing threats to human survival. To achieve sustainability, we must not only understand the ecological dynamics of a system, such as coral reefs, but must also promulgate regulations that promote beneficial behavior to address ecological stressors throughout the system. Furthermore, laws should reflect that systems operate at multiple spatial and temporal scales, thus requiring management across traditional legal jurisdictions. In this paper, we conducted a multi-scalar examination of law for sustainable ecosystems and how law pertains to coral reef ecosystems in particular. Findings indicate that, in order to achieve sustainability, we must develop new or reform existing legal mechanisms to protect ecosystems. C1 [Green, Olivia Odom; Garmestani, Ahjond S.; Hopton, Matthew E.; Heberling, Matthew T.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Hopton, ME (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM green.olivia@epa.gov; garmestani.ahjond@epa.gov; hopton.matthew@epa.gov; heberling.matt@epa.gov OI Heberling, Matthew/0000-0003-1120-612X; Hopton, Matt/0000-0001-7962-6820 NR 62 TC 5 Z9 5 U1 2 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD JUN PY 2014 VL 6 IS 6 BP 3534 EP 3551 DI 10.3390/su6063534 PG 18 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA AK9LF UT WOS:000338747900020 ER PT J AU Summers, JK Smith, LM Harwell, LC Case, JL Wade, CM Straub, KR Smith, HM AF Summers, J. Kevin Smith, Lisa M. Harwell, Linda C. Case, Jason L. Wade, Christina M. Straub, Kendra R. Smith, Heather M. TI An Index of Human Well-Being for the US: A TRIO Approach SO SUSTAINABILITY LA English DT Article DE well-being; index; TRIO; sustainability ID QUALITY-OF-LIFE AB In 2011, the US Environmental Protection Agency's (EPA) Office of Research and Development program, Sustainable and Healthy Communities, coined the term TRIO (Total Resources Impact Outcome) to represent approaches that fully incorporate all three pillars of community sustainability-environmental, economic and social. This holistic approach to sustainability is embodied in the Human Well-Being Index (HWBI) comprised of sub-indices representing environmental well-being, economic well-being and societal well-being (which includes basic human needs and subjective well-being). The development of the HWBI is described in this manuscript along with its application at national, state and county spatial scales. In addition, application at even smaller spatial scales (communities, neighborhoods, demographic and economic sub-groups, and even individuals) is discussed. The potential utility of HWBI for comparing the intended and unintended consequences of alternative decisions is described. C1 [Summers, J. Kevin; Smith, Lisa M.; Harwell, Linda C.] US EPA, Off Res & Dev, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Case, Jason L.; Wade, Christina M.; Straub, Kendra R.; Smith, Heather M.] Univ W Florida, US EPA, Student Serv Contractor, Pensacola, FL 32514 USA. [Case, Jason L.; Wade, Christina M.; Straub, Kendra R.; Smith, Heather M.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Summers, JK (reprint author), US EPA, Off Res & Dev, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM Summers.Kevin@epa.gov; Smith.Lisam@epa.gov; Harwell.Linda@epa.gov; jasonlcase87@gmail.com; Cmw49@students.uwf.edu; Straub.Kendra@nps.gov; rtshmrl11@bellsouth.net NR 39 TC 6 Z9 7 U1 4 U2 21 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD JUN PY 2014 VL 6 IS 6 BP 3915 EP 3935 DI 10.3390/su6063915 PG 21 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA AK9LF UT WOS:000338747900039 ER PT J AU Beaver, JR Manis, EE Loftin, KA Graham, JL Pollard, AI Mitchell, RM AF Beaver, John R. Manis, Erin E. Loftin, Keith A. Graham, Jennifer L. Pollard, Amina I. Mitchell, Richard M. TI Land use patterns, ecoregion, and microcystin relationships in US lakes and reservoirs: A preliminary evaluation SO HARMFUL ALGAE LA English DT Article DE Cyanobacteria; Ecoregion; Lake; Land use; Microcystin; Reservoir ID FRESH-WATER PHYTOPLANKTON; MIDWESTERN UNITED-STATES; CONTROLLING EUTROPHICATION; HARMFUL CYANOBACTERIA; CLIMATE-CHANGE; TROPHIC STATE; NEW-ZEALAND; BLOOMS; PHOSPHORUS; NUTRIENTS AB A statistically significant association was found between the concentration of total microcystin, a common class of cyanotoxins, in surface waters of lakes and reservoirs in the continental U.S. with watershed land use using data from 1156 water bodies sampled between May and October 2007 as part of the USEPA National Lakes Assessment. Nearly two thirds (65.8%) of the samples with microcystin concentrations >= 1.0 mu g/L (n = 126) were limited to three nutrient and water quality-based ecoregions (Corn Belt and Northern Great Plains, Mostly Glaciated Dairy Region, South Central Cultivated Great Plains) in watersheds with strong agricultural influence, canonical correlation analysis (CCA) indicated that both microcystin concentrations and cyanobacteria abundance were positively correlated with total nitrogen, dissolved organic carbon, and temperature; correlations with total phosphorus and water clarity were not as strong. This study supports a number of regional lake studies that suggest that land use practices are related to cyanobacteria abundance, and extends the potential impacts of agricultural land use in watersheds to include the production of cyanotoxins in lakes. (C) 2014 Elsevier B.V. All rights reserved. C1 [Beaver, John R.; Manis, Erin E.] BSA Environm Serv Inc, Beachwood, OH 44122 USA. [Loftin, Keith A.; Graham, Jennifer L.] US Geol Survey, Kansas Water Sci Ctr, Lawrence, KS 66049 USA. [Pollard, Amina I.; Mitchell, Richard M.] US EPA, Off Wetlands Oceans & Watersheds, Washington, DC 20460 USA. RP Beaver, JR (reprint author), BSA Environm Serv Inc, 23400 Mercantile Rd,Suite 8, Beachwood, OH 44122 USA. EM j.beaver@bsaenv.com NR 41 TC 13 Z9 13 U1 10 U2 62 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9883 EI 1878-1470 J9 HARMFUL ALGAE JI Harmful Algae PD JUN PY 2014 VL 36 BP 57 EP 62 DI 10.1016/j.hal.2014.03.005 PG 6 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA AK7QJ UT WOS:000338622500006 ER PT J AU Berrocal, VJ Gelfand, AE Holland, DM AF Berrocal, V. J. Gelfand, A. E. Holland, D. M. TI Assessing exceedance of ozone standards: a space-time downscaler for fourth highest ozone concentrations SO ENVIRONMETRICS LA English DT Article DE change of support; data fusion; hierarchical modeling; Markov chain Monte Carlo; national ambient air quality standards (NAAQS); r-th largest order statistic distribution ID SURFACE-LEVEL OZONE; NUMERICAL-MODELS; SPATIAL DATA; EXTREMES; MORTALITY; ATLANTA; OUTPUT AB The US Environmental Protection Agency is required to monitor, regulate, and set national ambient air quality standards for ozone. To investigate ozone exposure, the Environmental Protection Agency utilizes monitoring devices along with estimates of gridded ground level ozone concentration produced by a deterministic air quality model, the Community Multiscale Air Quality Model. These two sources of information enable inference regarding spatial exceedance of the National Ambient Air Quality Standard for ozone, which is given in terms of the level of the annual fourth highest ozone concentration.Here, we extend previous downscaling work to propose a spatial fourth highest extreme value downscaling model to assimilate annual fourth highest ozone concentration data at geo-coded locations with estimates at grid cell level derived from the Community Multiscale Air Quality Model model output. The resulting inference enables us to make probabilistic statements, with associated uncertainty, about the spatial variation in the chance of exceeding the standard. We apply our approach to data in the Eastern USA during years 2001-2008 and compare its predictive performance to that of downscaler models based on Gaussian processes applied to daily data. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Berrocal, V. J.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48105 USA. [Gelfand, A. E.] Duke Univ, Dept Stat Sci, Durham, NC 27707 USA. [Holland, D. M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. RP Gelfand, AE (reprint author), Duke Univ, Dept Stat Sci, Durham, NC 27707 USA. EM alan@stat.duke.edu NR 33 TC 0 Z9 0 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1180-4009 EI 1099-095X J9 ENVIRONMETRICS JI Environmetrics PD JUN PY 2014 VL 25 IS 4 SI SI BP 279 EP 291 DI 10.1002/env.2273 PG 13 WC Environmental Sciences; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Environmental Sciences & Ecology; Mathematics GA AJ2TT UT WOS:000337517100007 ER PT J AU Thakur, SA Nyska, A White, KL Smith, MJ Auttachoat, W Germolec, DR AF Thakur, Sheetal A. Nyska, Abraham White, Kimber L., Jr. Smith, Matthew J. Auttachoat, Wimolnut Germolec, Dori R. TI Immunomodulatory activity of orphan drug Elmiron (R) in female B6C3F1/N mice SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Immunotoxicity; Orphan drug; Sodium pentosan polysulfate; Interstitial cystitis ID POLYSULFATE-INDUCED THROMBOCYTOPENIA; PHASE-I TRIAL; PENTOSAN POLYSULFATE; INTERSTITIAL CYSTITIS; DENDRITIC CELLS; DRINKING-WATER; ANTIBODY; BLADDER; GAVAGE; ELISA AB Interstitial cystitis (IC) is a chronic disorder characterized by bladder discomfort and urinary urgency in the absence of identifiable infection. Despite the expanding use in IC treatment and other chronic conditions, the effects of Elmiron treatment on immune system remain unknown. Therefore, female B6C3F1/N mice were orally administered Elmiron (R) daily for 28-days at doses of 63, 125, 250, 500 or 1000 mg/kg to evaluate its immunomodulatory effects. Mice treated with Elmiron (R) had a significant increase in absolute numbers of splenic macrophages (63, 500 and 1000 mg/kg) and natural killer (NK) cells (250 and 1000 mg/kg). Elmiron (R) treatment did not affect the humoral immune response or T cell proliferative response. However, innate immune responses such as phagocytosis by liver macrophages (1000 mg/kg) and NK cell activity were enhanced (500 and 1000 mg/kg). Further analysis using a disease resistance model showed that Elmiron (R)-treated mice demonstrated significantly increased anti-tumor activity against B16F10 melanoma cells at the 500 and 1000 mg/kg doses. Collectively, we conclude that Elmiron (R) administration stimulates the immune system, increasing numbers of specific cell populations and enhancing macrophage phagocytosis and NK cell activity in female B6C3F1/N mice. This augmentation may have largely contributed to the reduced number of B16F10 melanoma tumors. (C) 2014 Published by Elsevier Ltd. C1 [Thakur, Sheetal A.; Germolec, Dori R.] Natl Inst Environm Hlth Sci, Toxicol Branch, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA. [Nyska, Abraham] Integrated Syst Lab, Res Triangle Pk, NC USA. [White, Kimber L., Jr.; Smith, Matthew J.; Auttachoat, Wimolnut] Virginia Commonwealth Univ, Richmond, VA USA. RP Germolec, DR (reprint author), Natl Inst Environm Hlth Sci, Div Natl Toxicol Program, 111 TW Alexander Dr,POB 12233,MD K2-15, Res Triangle Pk, NC 27709 USA. EM thakursa@niehs.nih.gov; germolec@niehs.nih.gov FU NIH, National Institute of Environmental Health Sciences FX This research was supported by the NIH, National Institute of Environmental Health Sciences. The authors would like to thank William M. Gwinn, Ph.D. (DNTP/NIEHS) and Kymberly M. Gowdy, Ph.D. (DIR/NIEHS) for their critical and editorial review. NR 42 TC 0 Z9 0 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 EI 1873-6351 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD JUN PY 2014 VL 68 BP 196 EP 203 DI 10.1016/j.fct.2014.03.015 PG 8 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA AJ4NL UT WOS:000337653000021 PM 24657363 ER PT J AU Pleil, JD Miekisch, W Stiegel, MA Beauchamp, J AF Pleil, Joachim D. Miekisch, Wolfram Stiegel, Matthew A. Beauchamp, Jonathan TI Extending breath analysis to the cellular level: current thoughts on the human microbiome and the expression of organic compounds in the human exposome SO JOURNAL OF BREATH RESEARCH LA English DT Article ID CLINICAL ENVIRONMENT; DISEASE C1 [Pleil, Joachim D.] US Environm Protect Agcy, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Miekisch, Wolfram] Univ Med Rostock, Dept Anaesthesia & Intens Care Med, Rostock, Germany. [Stiegel, Matthew A.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Beauchamp, Jonathan] Fraunhofer IVV, Dept Sensory Analyt, D-85354 Freising Weihenstephan, Germany. RP Pleil, JD (reprint author), US Environm Protect Agcy, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM pleil.joachim@epa.gov; wolfram.miekisch@uni-rostock.de; mstiegel@live.unc.edu; jonathan.beauchamp@ivv.fraunhofer.de RI Beauchamp, Jonathan/J-6914-2014; OI Beauchamp, Jonathan/0000-0003-1405-7625; Pleil, Joachim/0000-0001-8211-0796 NR 28 TC 14 Z9 14 U1 1 U2 15 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD JUN PY 2014 VL 8 IS 2 AR 029001 DI 10.1088/1752-7155/8/2/029001 PG 5 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA AJ0OB UT WOS:000337353100016 PM 24800639 ER PT J AU Sivaganensan, M Siefring, S Varma, M Haugland, RA AF Sivaganensan, Mano Siefring, Shawn Varma, Manju Haugland, Richard A. TI Comparison of Enterococcus quantitative polymerase chain reaction analysis results from Midwest US river samples using EPA Method 1611 and Method 1609 PCR reagents SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Enterococcus; qPCR; Recreational water quality; EPA Method 1611; EPA Method 1609 ID RECREATIONAL WATER-QUALITY; FECAL INDICATOR BACTERIA; RAPIDLY MEASURED INDICATORS; DEMONSTRATION PROJECT; MARINE BEACHES; QPCR; ILLNESS; QUANTIFICATION AB Enterococci target sequence density estimates from analyses of diluted river water DNA extracts by EPA Methods 1611 and 1609 and estimates with lower detection limits from undiluted DNA extracts by Method 1609 were in-distinguishable. These methods should be equally suitable for comparison with U.S. EPA 2012 Recreational Water Quality Criteria values. Published by Elsevier B.V. C1 [Sivaganensan, Mano] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Siefring, Shawn; Varma, Manju; Haugland, Richard A.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Haugland, RA (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM haugland.rich@epa.gov NR 32 TC 5 Z9 5 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JUN PY 2014 VL 101 BP 9 EP 17 DI 10.1016/j.mimet.2014.03.004 PG 9 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA AJ4PW UT WOS:000337659300002 PM 24681207 ER PT J AU Smucker, NJ AF Smucker, Nathan J. TI Algal assessment of threats to freshwater ecosystems: trends, challenges, and opportunities SO JOURNAL OF PHYCOLOGY LA English DT Article C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Smucker, NJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM smucker.nathan@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3646 EI 1529-8817 J9 J PHYCOL JI J. Phycol. PD JUN PY 2014 VL 50 IS 3 BP 407 EP 408 DI 10.1111/jpy.12191 PG 2 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA AJ3IN UT WOS:000337559800001 PM 26988315 ER PT J AU Smucker, NJ Drerup, SA Vis, ML AF Smucker, Nathan J. Drerup, Samuel A. Vis, Morgan L. TI Roles of benthic algae in the structure, function, and assessment of stream ecosystems affected by acid mine drainage SO JOURNAL OF PHYCOLOGY LA English DT Review DE biomonitoring; coal mines; diatoms; diversity; ecosystem services; nutrients; periphyton; pH; restoration; water quality ID PERIPHYTIC DIATOM COMMUNITIES; ORGANIC-MATTER BREAKDOWN; ROCKY-MOUNTAIN STREAM; WATER-QUALITY; BIOTIC INTEGRITY; HEAVY-METALS; FOOD WEBS; BIOLOGICAL ASSESSMENT; SOUTHEASTERN OHIO; ASSEMBLAGES AB Tens of thousands of stream kilometers worldwide are degraded by a legacy of acid loads, high metal concentrations, and altered habitat caused by acid mine drainage (AMD) from abandoned underground and surface mines. As the primary production base in streams, the condition of algal-dominated periphyton communities is particularly important to nutrient cycling, energy flow, and higher trophic levels. Here, we synthesize current knowledge regarding how AMD-associated stressors affect (i) algal communities and their use as ecological indicators, (ii) their functional roles in stream ecosystems, and (iii) how these findings inform management decisions and evaluation of restoration effectiveness. A growing body of research has found ecosystem simplification caused by AMD stressors. Species diversity declines, productivity decreases, and less efficient nutrient uptake and retention occur as AMD severity increases. New monitoring approaches, indices of biological condition, and attributes of algal community structure and function effectively assess AMD severity and effectiveness of management practices. Measures of ecosystem processes, such as nutrient uptake rates, extracellular enzyme activities, and metabolism, are increasingly being used as assessment tools, but remain in their infancy relative to traditional community structure-based approaches. The continued development, testing, and implementation of functional measures and their use alongside community structure metrics will further advance assessments, inform management decisions, and foster progress toward restoration goals. Algal assessments will have important roles in making progress toward improving and sustaining the water quality, ecological condition, and ecosystem services of streams in regions affected by the legacy of unregulated coal mining. C1 [Smucker, Nathan J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Drerup, Samuel A.; Vis, Morgan L.] Ohio Univ, Dept Environm & Plant Biol, Athens, OH 45701 USA. RP Smucker, NJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM smucker.nathan@epa.gov NR 124 TC 6 Z9 6 U1 7 U2 74 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3646 EI 1529-8817 J9 J PHYCOL JI J. Phycol. PD JUN PY 2014 VL 50 IS 3 BP 425 EP 436 DI 10.1111/jpy.12184 PG 12 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA AJ3IN UT WOS:000337559800003 PM 26988317 ER PT J AU Jicha, TM Johnson, LB Hill, BH Regal, RR Elonen, CM Pearson, MS AF Jicha, T. M. Johnson, L. B. Hill, B. H. Regal, R. R. Elonen, C. M. Pearson, M. S. TI SPATIAL AND TEMPORAL PATTERNS OF NITRIFICATION RATES IN FORESTED FLOODPLAIN WETLAND SOILS OF UPPER MISSISSIPPI RIVER POOL 8 SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE nitrification; forested floodplain; Mississippi River; nutrient cycling ID GULF-OF-MEXICO; NITROGEN MINERALIZATION; DESERT STREAM; DECOMPOSING LEAF; HEADWATER STREAM; ORGANIC-CARBON; FUTURE-TRENDS; DENITRIFICATION; ECOSYSTEMS; WATER AB Overbank flooding is thought to be a critical process controlling nitrogen retention and cycling. Yet, studies aimed at quantifying these effects, specifically nitrification, are relatively few. In this study, we investigated the effects of season and flood frequency on soil nitrification rates in forested floodplains of Upper Mississippi River, Pool 8. Samples were collected from three plots within each site in April, August and November 2006. Plots were equally divided among three flood frequency categories as follows: rare, moderate and frequent based on elevation and flood probability model. We found a significant difference in nitrification rates among flood frequency categories as follows: rare>moderate>frequent (F=4.49, p<0.01) and over season: spring>summer>autumn (F=8.88, p<0.01). Regression for all samples showed that elevation, NH4-N, bulk density and soil temperature explained a moderate amount of variation in nitrification rates (R2=0.29, p<0.01). Models for moderately flooded, spring, summer and autumn samples improved when analysed individually. The absence of a correlation between nitrification rates and hydrology limits our ability to predict rates based on hydrology alone. The model based on elevation and season allows us to estimate nitrification rates with moderate confidence (R2=0.27, p<0.01). A rough calculation of forest floodplain nitrification rates suggests that 473mt of NO3-N are produced annually, about 0.5% of Pool 8 total annual NO3-N budget. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Jicha, T. M.; Hill, B. H.; Elonen, C. M.; Pearson, M. S.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Midcontinent Ecol Div, Duluth, MN USA. [Jicha, T. M.] Univ Minnesota, Dept Biol, Duluth, MN 55812 USA. [Johnson, L. B.] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA. [Regal, R. R.] Univ Minnesota, Dept Math & Stat, Duluth, MN 55812 USA. RP Jicha, TM (reprint author), USEPA ORD NHEERL, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM jicha.terri@epa.gov FU USEPA FX I would like to thank the following people for their help and support: Matthew Nelson and Katherine Disterhaft, lab support; Matthew Starry and Tatiana Nawrocki, CSC, Duluth, MN, GIS support. This project greatly benefited from the discussion and advice from George Host, NRRI; Bill Richardson, USGS; and Eric Strauss, University of Wisconsin- La Crosse. Funding for this project has been provided in full by the USEPA. This paper does not necessarily reflect the views of the USEPA nor does it constitute endorsement or recommendation for use of trade names or commercial products mentioned within. NR 53 TC 2 Z9 2 U1 1 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD JUN PY 2014 VL 30 IS 5 BP 650 EP 662 DI 10.1002/rra.2663 PG 13 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AJ3JS UT WOS:000337563000011 ER PT J AU Kleinstreuer, NC Yang, J Berg, EL Knudsen, TB Richard, AM Martin, MT Reif, DM Judson, RS Polokoff, M Dix, DJ Kavlock, RJ Houck, KA AF Kleinstreuer, Nicole C. Yang, Jian Berg, Ellen L. Knudsen, Thomas B. Richard, Ann M. Martin, Matthew T. Reif, David M. Judson, Richard S. Polokoff, Mark Dix, David J. Kavlock, Robert J. Houck, Keith A. TI Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms SO NATURE BIOTECHNOLOGY LA English DT Article ID MAP KINASE INHIBITOR; DRUG DISCOVERY; PERFLUOROOCTANE SULFONATE; ENVIRONMENTAL CHEMICALS; RHEUMATOID-ARTHRITIS; PREDICTIVE MODELS; BIOLOGY APPROACH; BIOMAP ANALYSIS; BREAST-CANCER; RECEPTOR AB Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches. Our approach, the US Environmental Protection Agency's ToxCast program, utilizes a large suite of in vitro and model organism assays to interrogate important chemical libraries and computationally analyze bioactivity profiles. Here we evaluated one component of the ToxCast program, the use of primary human cell systems, by screening for chemicals that disrupt physiologically important pathways. Chemical-response signatures for 87 endpoints covering molecular functions relevant to toxic and therapeutic pathways were generated in eight cell systems for 641 environmental chemicals and 135 reference pharmaceuticals and failed drugs. Computational clustering of the profiling data provided insights into the polypharmacology and potential off-target effects for many chemicals that have limited or no toxicity information. The endpoints measured can be closely linked to in vivo outcomes, such as the upregulation of tissue factor in endothelial cell systems by compounds linked to the risk of thrombosis in vivo. Our results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways. C1 [Kleinstreuer, Nicole C.; Knudsen, Thomas B.; Richard, Ann M.; Martin, Matthew T.; Reif, David M.; Judson, Richard S.; Dix, David J.; Kavlock, Robert J.; Houck, Keith A.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Yang, Jian; Berg, Ellen L.; Polokoff, Mark] Div DiscoveRx Inc, BioSeek, San Francisco, CA USA. RP Houck, KA (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM houck.keith@epa.gov OI Judson, Richard/0000-0002-2348-9633; Reif, David/0000-0001-7815-6767; Kleinstreuer, Nicole/0000-0002-7914-3682 NR 52 TC 53 Z9 55 U1 2 U2 43 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1087-0156 EI 1546-1696 J9 NAT BIOTECHNOL JI Nat. Biotechnol. PD JUN PY 2014 VL 32 IS 6 BP 583 EP + DI 10.1038/nbt.2914 PG 12 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AI9EV UT WOS:000337233800022 PM 24837663 ER PT J AU Popovici, J White, CP Hoelle, J Kinkle, BK Lytle, DA AF Popovici, Jonathan White, Colin P. Hoelle, Jill Kinkle, Brian K. Lytle, Darren A. TI Characterization of the cell surface properties of drinking water pathogens by microbial adhesion to hydrocarbon and electrophoretic mobility measurements SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE Electrophoretic mobility; Hydrophobicity; Surface; Pathogen; Drinking water ID ESCHERICHIA-COLI O157-H7; BUCCAL EPITHELIAL-CELLS; BACTERIAL ADHESION; CANDIDA-ALBICANS; POROUS-MEDIA; STREPTOCOCCUS-SALIVARIUS; PSEUDOMONAS-AERUGINOSA; COATED HYDROXYAPATITE; STAINLESS-STEEL; IONIC-STRENGTH AB The surface characteristics of microbial cells directly influence their mobility and behavior within aqueous environments. The cell surface hydrophobicity (CSH) and electrophoretic mobility (EPM) of microbial cells impact a number of interactions and processes including aggregation, adhesion to surfaces, and stability of the cells within the aqueous environments. These cell characteristics are unique to the bacterial species and are a reflection of the large diversity of surface structures, proteins, and appendages of microorganisms. CSH and EPM of bacterial cells contribute substantially to the effectiveness of drinking water treatment to remove them, and therefore an investigation of these properties will be useful in predicting their removal through drinking water treatment processes and transport through drinking water distribution systems. EPM and CSH measurements of six microbiological pathogen or surrogate species suspended in phosphate-buffered water are reported in this work. Two strains of Vibrio cholerae were hydrophobic, while three strains of Escherichia coli were hydrophilic. Bacillus cereus was categorized as moderately hydrophobic. The strains of E. coli had the highest (most negative) EPM. Based on the measurements, E. coli species is predicted to be most difficult to remove from water while V. cholerae will be the easiest to remove. (C) 2014 Elsevier B.V. All rights reserved. C1 [Popovici, Jonathan; Kinkle, Brian K.] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45220 USA. [White, Colin P.] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Hoelle, Jill; Lytle, Darren A.] US EPA, ORD, NMRML, WSWRD, Cincinnati, OH 45268 USA. RP Lytle, DA (reprint author), US EPA, ORD, NMRML, WSWRD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM popovici.jonathan@epa.gov; white.colin@epa.gov; lytle.darren@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein. It has been subjected to the Agency's peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 59 TC 3 Z9 3 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7765 EI 1873-4367 J9 COLLOID SURFACE B JI Colloid Surf. B-Biointerfaces PD JUN 1 PY 2014 VL 118 BP 126 EP 132 DI 10.1016/j.colsurfb.2014.03.033 PG 7 WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials SC Biophysics; Chemistry; Materials Science GA AI6VA UT WOS:000337013900017 PM 24815929 ER PT J AU Wigand, C Roman, CT Davey, E Stolt, M Johnson, R Hanson, A Watson, EB Moran, SB Cahoon, DR Lynch, JC Rafferty, P AF Wigand, Cathleen Roman, Charles T. Davey, Earl Stolt, Mark Johnson, Roxanne Hanson, Alana Watson, Elizabeth B. Moran, S. Bradley Cahoon, Donald R. Lynch, James C. Rafferty, Patricia TI Below the disappearing marshes of an urban estuary: historic nitrogen trends and soil structure SO ECOLOGICAL APPLICATIONS LA English DT Article DE belowground biomass; carbon dioxide emissions; computer-aided tomography (CT) imaging; eutrophication; Jamaica Bay; marsh loss; peat swelling; radiometric dating; sea level rise; shear stress ID LONG-ISLAND SOUND; HIGH-PRECISION MEASUREMENTS; SEA-LEVEL RISE; SALT-MARSH; SPARTINA-ALTERNIFLORA; NEW-ENGLAND; ISOTOPE SIGNATURES; VERTICAL ACCRETION; SEDIMENT ELEVATION; COASTAL WETLANDS AB Marshes in the urban Jamaica Bay Estuary, New York, USA are disappearing at an average rate of 13 ha/yr, and multiple stressors (e.g., wastewater inputs, dredging activities, groundwater removal, and global warming) may be contributing to marsh losses. Among these stressors, wastewater nutrients are suspected to be an important contributing cause of marsh deterioration. We used census data, radiometric dating, stable nitrogen isotopes, and soil surveys to examine the temporal relationships between human population growth and soil nitrogen; and we evaluated soil structure with computer-aided tomography, surface elevation and sediment accretion trends, carbon dioxide emissions, and soil shear strength to examine differences among disappearing (Black Bank and Big Egg) and stable marshes (JoCo). Radiometric dating and nitrogen isotope analyses suggested a rapid increase in human wastewater nutrients beginning in the late 1840s, and a tapering off beginning in the 1930s when wastewater treatment plants (WWTPs) were first installed. Current WWTPs nutrient loads to Jamaica Bay are approximately 13 995 kg N/d and 2767 kg P/d. At Black Bank, the biomass and abundance of roots and rhizomes and percentage of organic matter on soil were significantly lower, rhizomes larger in diameter, carbon dioxide emission rates and peat particle density significantly greater, and soil strength significantly lower compared to the stable JoCo Marsh, suggesting Black Bank has elevated decomposition rates, more decomposed peat, and highly waterlogged peat. Despite these differences, the rates of accretion and surface elevation change were similar for both marshes, and the rates of elevation change approximated the long term relative rate of sea level rise estimated from tide gauge data at nearby Sandy Hook, New Jersey. We hypothesize that Black Bank marsh kept pace with sea level rise by the accretion of material on the marsh surface, and the maintenance of soil volume through production of larger diameter rhizomes and swelling (dilation) of waterlogged peat. JoCo Marsh kept pace with sea-level rise through surface accretion and soil organic matter accumulation. Understanding the effects of multiple stressors, including nutrient enrichment, on soil structure, organic matter accumulation, and elevation change will better inform management decisions aimed at maintaining and restoring coastal marshes. C1 [Wigand, Cathleen; Davey, Earl; Johnson, Roxanne; Hanson, Alana; Watson, Elizabeth B.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Roman, Charles T.] Univ Rhode Isl, North Atlantic Coast Cooperat Ecosyst Studies Uni, Natl Pk Serv, Narragansett, RI 02882 USA. [Stolt, Mark] Univ Rhode Isl, Kingston Coastal Inst 112, Dept Nat Resources Sci, Kingston, RI 02881 USA. [Moran, S. Bradley] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. [Cahoon, Donald R.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD 20705 USA. [Lynch, James C.] Northeast Coastal & Barrier Network, Natl Pk Serv, Washington, DC 20007 USA. [Rafferty, Patricia] Natl Pk Serv, Patchogue, NY 11772 USA. RP Wigand, C (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM wigand.cathleen@epa.gov NR 81 TC 16 Z9 17 U1 9 U2 86 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1051-0761 EI 1939-5582 J9 ECOL APPL JI Ecol. Appl. PD JUN PY 2014 VL 24 IS 4 BP 633 EP 649 PG 17 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA AI7XX UT WOS:000337117400004 PM 24988765 ER PT J AU Hiller, S DeKroon, R Xu, LQ Robinette, J Winnik, W Alzate, O Simington, S Maeda, N Yi, XW AF Hiller, Sylvia DeKroon, Robert Xu, Longquan Robinette, Jennifer Winnik, Witold Alzate, Oscar Simington, Stephen Maeda, Nobuyo Yi, Xianwen TI alpha-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE Lipoic acid; Antioxidant; Mitochondria; Body energy; Free radicals ID OF-CELLULAR-FUNCTIONS; E-DEFICIENT MICE; NITRIC-OXIDE; SEPTIC SHOCK; HYDROGEN-PEROXIDE; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; REDOX-REGULATION; SKELETAL-MUSCLE; CYTOCHROME-C AB Hypothermia is a key symptom of sepsis, but the mechanism(s) leading to hypothermia during sepsis is largely unknown and thus no effective therapy is available for hypothermia. Therefore, it is important to investigate the mechanism and develop effective therapeutic methods. Lipopolysaccharide (LPS)-induced hypothermia accompanied by excess nitric oxide (NO) production leads to a reduction in energy production in wild-type mice. However, mice lacking inducible nitric oxide synthase did not suffer from LPS-induced hypothermia, suggesting that hypothermia is associated with excess NO production during sepsis. This observation is supported by the treatment of wild-type mice with alpha-lipoic acid (LA) in that it effectively attenuates LPS-induced hypothermia with decreased NO production. We also found that LA partially restored ATP production, and activities of the mitochondrial enzymes involved in energy metabolism, which were inhibited during sepsis. These data suggest that hypothermia is related to mitochondrial dysfunction, which is probably compromised by excess NO production and that LA administration attenuates hypothermia mainly by protecting mitochondrial enzymes from NO damage. (C) 2014 Elsevier Inc. All rights reserved. C1 [Hiller, Sylvia; Xu, Longquan; Simington, Stephen; Maeda, Nobuyo; Yi, Xianwen] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA. [DeKroon, Robert] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Robinette, Jennifer] Univ N Carolina, Program Mol Biol & Biotechnol, Chapel Hill, NC 27599 USA. [Winnik, Witold] US EPA, Prote Res Core Unit, NHEERL, Res Triangle Pk, NC 27711 USA. [Alzate, Oscar] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Dept Biomed Sci, El Paso, TX 79905 USA. RP Yi, XW (reprint author), Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA. EM xyi2000@med.unc.edu FU UNC University Research Council; UNC-CH Nutrition Obesity Research Center [DK056350]; [HL42630]; [HL087946] FX This project was supported by HL42630 and HL087946 (N.M.), by UNC University Research Council grants, and in part by DK056350 to the UNC-CH Nutrition Obesity Research Center (X.Y.). The authors thank Dr. Rosaline Coleman for her insightful suggestions. The manuscript was reviewed by the U.S. Environmental Protection Agency, NHEERL, and approved for publication. The authors thank Drs. P.R. Kodavanti and J. Royland for their invaluable suggestions. Approval does not signify that the contents reflect the views of the U.S. EPA, nor that the mention of trade names or commercial products could constitute endorsement or recommendation for use. NR 61 TC 3 Z9 5 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 EI 1873-4596 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD JUN PY 2014 VL 71 BP 362 EP 367 DI 10.1016/j.freeradbiomed.2014.03.022 PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA AI5FP UT WOS:000336891100032 PM 24675228 ER PT J AU Tsang, M Meyer, D Hawkins, T Ingwersen, W Sayre, P AF Tsang, Michael Meyer, David Hawkins, Troy Ingwersen, Wesley Sayre, Phil TI Life cycle assessment for emerging materials: case study of a garden bed constructed from lumber produced with three different copper treatments SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT LA English DT Article DE ACQ; Emerging materials; Life cycle assessment; MCQ; Micronized copper; Treated lumber ID ENGINEERED NANOMATERIALS; IMPACT ASSESSMENT; TOXICITY; SOLUBILITY; FATE; WOOD; NANOPARTICLES; ENVIRONMENT; C-60 AB The objective of this research was to evaluate the appropriateness of using life cycle assessment (LCA) for new applications that incorporate emerging materials and involve site-specific scenarios. Cradle-to-grave impacts of copper-treated lumber used in a raised garden bed are assessed to identify key methodological challenges and recommendations applying LCA for such purposes as well as to improve sustainability within this application. The functional unit is a raised garden bed measuring 6.67 board feet (bf) in volume over a period of 20 years. The garden beds are made from softwood lumber such as southern yellow pine. The two treatment options considered were alkaline copper quaternary and micronized copper quaternary. Ecoinvent 2.2 provided certain life cycle inventory (LCI) data needed for the production of each garden bed, while additional primary and secondary sources were accessed to supplement the LCI. Primary data were not available for all relevant inventory requirements, as was anticipated, but enough secondary data were gathered to conduct a screening-level LCA on these raised garden bed applications. A notable finding was that elimination of organic solvent could result in a more sustainable lumber treatment product. Conclusions are limited by data availability and key methodological challenges facing LCA and emerging materials. Although important data and methodological challenges facing LCA and emerging materials exist, this LCA captured material and process changes that were important drivers of environmental impacts. LCA methods need to be amended to reflect the properties of emerging materials that determine their fate, transport, and impacts to the environment and health. It is not necessary that all recommendations come to light before LCA is applied in the context of emerging materials. Applications of such materials involve many inputs beyond emerging materials that are already properly assessed by LCA. Therefore, LCA should be used in its current state to enhance the decision-making context for the sustainable development of these applications. C1 [Meyer, David; Hawkins, Troy; Ingwersen, Wesley; Sayre, Phil] US EPA, Sustainable Technol Div, Cincinnati, OH 45268 USA. [Tsang, Michael] US EPA, Assoc Sch Publ Hlth Fellow, Washington, DC 20004 USA. RP Tsang, M (reprint author), US EPA, Assoc Sch Publ Hlth Fellow, 1300 Penn Ave NW, Washington, DC 20004 USA. EM mptsang@gmail.com OI Ingwersen, Wesley/0000-0002-9614-701X NR 49 TC 2 Z9 2 U1 3 U2 14 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0948-3349 EI 1614-7502 J9 INT J LIFE CYCLE ASS JI Int. J. Life Cycle Assess. PD JUN PY 2014 VL 19 IS 6 BP 1345 EP 1355 DI 10.1007/s11367-014-0726-1 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AI7IY UT WOS:000337062400016 ER PT J AU Williamson, CE Zepp, RG Lucas, RM Madronich, S Austin, AT Ballare, CL Norval, M Sulzberger, B Bais, AF McKenzie, RL Robinson, SA Hader, DP Paul, ND Bornman, JF AF Williamson, Craig E. Zepp, Richard G. Lucas, Robyn M. Madronich, Sasha Austin, Amy T. Ballare, Carlos L. Norval, Mary Sulzberger, Barbara Bais, Alkiviadis F. McKenzie, Richard L. Robinson, Sharon A. Haeder, Donat-P. Paul, Nigel D. Bornman, Janet F. TI Solar ultraviolet radiation in a changing climate SO NATURE CLIMATE CHANGE LA English DT Article ID NONMELANOMA SKIN-CANCER; VITAMIN-D DEFICIENCY; UV-B; OZONE DEPLETION; CRYPTOSPORIDIUM-PARVUM; POPULAR ATTITUDES; CROP PRODUCTION; SUN PROTECTION; US POPULATION; EXPOSURE AB The projected large increases in damaging ultraviolet radiation as a result of global emissions of ozone-depleting substances have been forestalled by the success of the Montreal Protocol. New challenges are now arising in relation to climate change. We highlight the complex interactions between the drivers of climate change and those of stratospheric ozone depletion, and the positive and negative feedbacks among climate, ozone and ultraviolet radiation. These will result in both risks and benefits of exposure to ultraviolet radiation for the environment and human welfare. This Review synthesizes these new insights and their relevance in a world where changes in climate as well as in stratospheric ozone are altering exposure to ultraviolet radiation with largely unknown consequences for the biosphere. C1 [Williamson, Craig E.] Miami Univ, Dept Biol, Oxford, OH 45056 USA. [Zepp, Richard G.] US EPA, Athens, GA 30605 USA. [Lucas, Robyn M.] Univ Western Australia, Telethon Kids Inst, Perth, WA 6008, Australia. [Lucas, Robyn M.] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT 0200, Australia. [Madronich, Sasha] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Austin, Amy T.; Ballare, Carlos L.] Univ Buenos Aires, IFEVA, Buenos Aires, DF, Argentina. [Austin, Amy T.; Ballare, Carlos L.] IIB Univ Nacl San Martin, CONICET, Buenos Aires, DF, Argentina. [Norval, Mary] Univ Edinburgh, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland. [Sulzberger, Barbara] Swiss Fed Inst Aquat Sci & Technol Eawag, CH-8600 Dubendorf, Switzerland. [Bais, Alkiviadis F.] Aristotle Univ Thessaloniki, Lab Atmospher Phys, Thessaloniki 54124, Greece. [McKenzie, Richard L.] Natl Inst Water & Atmospher Res NIWA, Lauder 9352, Cent Otago, New Zealand. [Robinson, Sharon A.] Univ Wollongong, Sch Biol Sci, Inst Conservat Biol & Environm Management, Wollongong, NSW 2522, Australia. [Paul, Nigel D.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England. [Bornman, Janet F.] Curtin Univ, IIAFS, Perth, WA 6845, Australia. RP Bornman, JF (reprint author), Curtin Univ, IIAFS, Bldg 408,POB U1987, Perth, WA 6845, Australia. EM janet.bornman@curtin.edu.au RI Madronich, Sasha/D-3284-2015; Ballare, Carlos/F-5141-2011; Bais, Alkiviadis/D-2230-2009; Robinson, Sharon/B-2683-2008; OI Madronich, Sasha/0000-0003-0983-1313; Ballare, Carlos/0000-0001-9129-4531; Bais, Alkiviadis/0000-0003-3899-2001; Robinson, Sharon/0000-0002-7130-9617; Austin, Amy/0000-0002-7468-5861 NR 100 TC 63 Z9 65 U1 25 U2 154 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD JUN PY 2014 VL 4 IS 6 BP 434 EP 441 DI 10.1038/NCLIMATE2225 PG 8 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AI8EC UT WOS:000337138700016 ER PT J AU Goldstein, BD Brooks, BW Cohen, SD Gates, AE Honeycutt, ME Morris, JB Orme-Zavaleta, J Penning, TM Snawder, J AF Goldstein, Bernard D. Brooks, Bryan W. Cohen, Steven D. Gates, Alexander E. Honeycutt, Michael E. Morris, John B. Orme-Zavaleta, Jennifer Penning, Trevor M. Snawder, John TI The Role of Toxicological Science in Meeting the Challenges and Opportunities of Hydraulic Fracturing SO TOXICOLOGICAL SCIENCES LA English DT Editorial Material DE hydraulic fracturing; mixtures; shale gas; methane; benzene; radon ID RATIONAL MOLECULAR DESIGN; MARCELLUS SHALE REGION; NATURAL-GAS EXTRACTION; DRINKING-WATER WELLS; METHANE CONTAMINATION; AQUATIC TOXICITY; RISK-ASSESSMENT; WASTE-WATER; IMPACTS; PENNSYLVANIA AB We briefly describe how toxicology can inform the discussion and debate of the merits of hydraulic fracturing by providing information on the potential toxicity of the chemical and physical agents associated with this process, individually and in combination. We consider upstream activities related to bringing chemical and physical agents to the site, on-site activities including drilling of wells and containment of agents injected into or produced from the well, and downstream activities including the flow/removal of hydrocarbon products and of produced water from the site. A broad variety of chemical and physical agents are involved. As the industry expands this has raised concern about the potential for toxicological effects on ecosystems, workers, and the general public. Response to these concerns requires a concerted and collaborative toxicological assessment. This assessment should take into account the different geology in areas newly subjected to hydraulic fracturing as well as evolving industrial practices that can alter the chemical and physical agents of toxicological interest. The potential for ecosystem or human exposure to mixtures of these agents presents a particular toxicological and public health challenge. These data are essential for developing a reliable assessment of the potential risks to the environment and to human health of the rapidly increasing use of hydraulic fracturing and deep underground horizontal drilling techniques for tightly bound shale gas and other fossil fuels. Input from toxicologists will be most effective when employed early in the process, before there are unwanted consequences to the environment and human health, or economic losses due to the need to abandon or rework costly initiatives. C1 [Goldstein, Bernard D.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15261 USA. [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA. [Cohen, Steven D.] Massachusetts Coll Pharm & Hlth Sci, Sch Pharm Worcester Manchester, Worcester, MA 01608 USA. [Gates, Alexander E.] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA. [Honeycutt, Michael E.] Texas Commiss Environm Qual, Div Toxicol, Austin, TX 78711 USA. [Morris, John B.] Univ Connecticut, Sch Pharm, Storrs, CT 06269 USA. [Orme-Zavaleta, Jennifer] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Penning, Trevor M.] Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA. [Snawder, John] Natl Inst Occupat Safety & Hlth Appl Res & Techno, Ctr Dis Control & Prevent, Williamstown, KY 41097 USA. RP Goldstein, BD (reprint author), 130 DeSoto St,A710 Crabtree Hall, Pittsburgh, PA 15261 USA. EM bdgold@pitt.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Penning, Trevor/0000-0002-3937-1066 FU NIEHS NIH HHS [P30 ES013508, P30-ES013508] NR 66 TC 17 Z9 17 U1 3 U2 85 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JUN PY 2014 VL 139 IS 2 BP 271 EP 283 DI 10.1093/toxsci/kfu061 PG 13 WC Toxicology SC Toxicology GA AI7MO UT WOS:000337075900001 PM 24706166 ER PT J AU Lu, SS Sobus, JR Sallsten, G Albin, M Pleil, JD Gudmundsson, A Madden, MC Strandberg, B Wierzbicka, A Rappaport, SM AF Lu, Sixin S. Sobus, Jon R. Sallsten, Gerd Albin, Maria Pleil, Joachim D. Gudmundsson, Anders Madden, Michael C. Strandberg, Bo Wierzbicka, Aneta Rappaport, Stephen M. TI Are urinary PAHs biomarkers of controlled exposure to diesel exhaust? SO BIOMARKERS LA English DT Article DE Biomarker; diesel exhaust; PAHs; polycyclic aromatic hydrocarbons; urine ID POLYCYCLIC AROMATIC-HYDROCARBONS; SOLID-PHASE MICROEXTRACTION; COKE-OVEN WORKERS; MASS-SPECTROMETRY; LUNG-CANCER; ASPHALT; CHAMBER; ENGINE AB Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 mu g/m(3). C1 [Lu, Sixin S.] Univ Calif Berkeley, Coll Nat Resources, Berkeley, CA 94720 USA. [Sobus, Jon R.; Pleil, Joachim D.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Sallsten, Gerd; Strandberg, Bo] Univ Gothenburg, Gothenburg, Sweden. [Albin, Maria; Gudmundsson, Anders; Wierzbicka, Aneta] Lund Univ, S-22100 Lund, Sweden. [Madden, Michael C.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Rappaport, Stephen M.] Univ Calif Berkeley, Sch Publ Hlth, Ctr Exposure Biol, Berkeley, CA 94720 USA. RP Rappaport, SM (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. EM SL@berkeley.edu; srappaport@berkeley.edu OI Pleil, Joachim/0000-0001-8211-0796 FU National Science Foundation [DGE-0946797]; National Institute for Environmental Health Sciences [P42ES05948, P42ES04705]; Swedish Research Council FORMAS FX This work was supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-0946797 to S. S. L. and by grants P42ES05948 and P42ES04705 from the National Institute for Environmental Health Sciences (to S. M. R.). The Lund study is a part of a larger DINO project "Health effects of combined exposure to diesel and noise" financed by the Swedish Research Council FORMAS. NR 29 TC 2 Z9 2 U1 1 U2 10 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1354-750X EI 1366-5804 J9 BIOMARKERS JI Biomarkers PD JUN PY 2014 VL 19 IS 4 BP 332 EP 339 DI 10.3109/1354750X.2014.910553 PG 8 WC Biotechnology & Applied Microbiology; Toxicology SC Biotechnology & Applied Microbiology; Toxicology GA AI3AI UT WOS:000336730300011 PM 24754404 ER PT J AU Zhang, X Rygwelski, KR Kreis, RG Rossmann, R AF Zhang, Xiaomi Rygwelski, Kenneth R. Kreis, Russell G., Jr. Rossmann, Ronald TI A mercury transport and fate model (LM2-Mercury) for mass budget assessment of mercury cycling in Lake Michigan SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Water quality modeling; Mass balance model; Mass budget assessment; Mercury; Lake Michigan ID ST-LAWRENCE-RIVER; ELEMENTAL MERCURY; GREAT-LAKES; DEPOSITION; WATER; BALANCE; BIOACCUMULATION; TRANSFORMATION; COEFFICIENTS; SEDIMENTS AB LM2-Mercury, a mercury mass balance model, was developed to simulate and evaluate the transport, fate, and biogeochemical transformations of mercury in Lake Michigan. The model simulates total suspended and resuspendable solids (TSRS), dissolved organic carbon (DOC), and total, elemental, divalent, and methylmercury as state variables. Simplified processes among the mercury state variables including net methylation, net reduction of divalent mercury, and reductive demethylation are incorporated in the model. Volatilization of elemental mercury as a kinetic (phase transfer) process and partitioning of total, divalent, and methylmercury as a set of instantaneous equilibrium processes were also simulated. The model was calibrated to data collected in 1994 and 1995 and corroborated by comparing model output generated from a long-term model hindcast to total mercury measured in high quality sediment profiles. Model hindcast predictions of total mercury in the water column were within estimates of total mercury calculated from observed lake trout bioaccumulation factors. Using the model, a mass budget assessment of mercury cycling in the lake was conducted. Atmospheric deposition, including wet and dry (particle) deposition and absorption of gaseous divalent mercury, was the dominant source of total mercury to the lake, followed by sediment resuspension, and then tributary loads. The major loss mechanism of total mercury from the water was associated with the settling of solids, followed by net volatilization. Methylmercury loading associated with wet deposition was the dominant source to the lake, followed by tributary loadings, and in situ net methylation. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Zhang, Xiaomi] Trinity Engn Associates, Inc Large Lakes Res Stn, Grosse Ile, MI 48138 USA. [Rygwelski, Kenneth R.; Kreis, Russell G., Jr.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Large Lakes, Midcontinent Ecol Div,Large Lakes & Rivers Foreca, Grosse Ile, MI 48138 USA. [Rossmann, Ronald] Large Lakes Res Stn, Grosse Ile, MI 48138 USA. RP Rygwelski, KR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Large Lakes, Midcontinent Ecol Div,Large Lakes & Rivers Foreca, 9311 Groh Rd, Grosse Ile, MI 48138 USA. EM rygwelski.kenneth@epa.gov FU U.S. Environmental Protection Agency (Great Lakes National Program Office, Office of Research and Development) [EP-D-11-092] FX Funding sources for this project came from the U.S. Environmental Protection Agency (Great Lakes National Program Office, Office of Research and Development, and Contract No. EP-D-11-092). It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. Special thanks goes out to the agency personnel at the Large Lakes Research Station, Grosse Ile, Michigan for general support and technical direction; anonymous technical reviewers (J. Great Lakes Res.); and Dr. James Pauer and Dr. Mark Rowe for their helpful comments. NR 50 TC 1 Z9 1 U1 6 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD JUN PY 2014 VL 40 IS 2 BP 347 EP 359 DI 10.1016/j.jglr.2014.03.008 PG 13 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AI1TI UT WOS:000336637300014 ER PT J AU Bellinger, BJ Jicha, TM Lehto, LP Seifert-Monson, LR Bolgrien, DW Starry, MA Angradi, TR Pearson, MS Elonen, C Hill, BH AF Bellinger, Brent J. Jicha, Terri M. Lehto, LaRae P. Seifert-Monson, Lindsey R. Bolgrien, David W. Starry, Matthew A. Angradi, Theodore R. Pearson, Mark S. Elonen, Colleen Hill, Brian H. TI Sediment nitrification and denitrification in a Lake Superior estuary SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Laurentian; Great Lakes; Denitrification; Nitrification; St Louis River Estuary; Nitrous oxide ID EVERGLADES WETLAND SOILS; UPPER MISSISSIPPI RIVER; GREAT-LAKES; COASTAL WETLANDS; NITROGEN-CYCLE; NITRATE UPTAKE; FRESH-WATER; RATES; ECOSYSTEM; PHOSPHORUS AB Inorganic nitrogen (N) transformations and removal in aquatic sediments are microbially mediated, and rates influence N-transport. In this study we related physicochemical properties of a large Great Lakes embayment, the St. Louis River Estuary (SLRE) of western Lake Superior, to sediment N-transformation rates. We tested for associations among rates and N-inputs, vegetation biomass, and temperature. We measured rates of nitrification (NIT), unamended base denitrification (DeNIT), and potential denitrification [denitrifying enzyme activity (DEA)] in 2011 and 2012 across spatial and depth zones. In vegetated habitats, NIT and DeNIT rates were highest in deep (ca. 2 m) water (249 and 2111 mg N m(-2) d(-1), respectively) and in the upper and lower reaches of the SLRE (>126 and 274 mg N m(-2) d(-1), respectively). Rates of DEA were similar among zones. In 2012, NIT, DeNIT, and DEA rates were highest in July, May, and June, respectively. System-wide, we observed highest NIT (223 and 287 mg Nm(-2) d(-1)) and DeNIT (77 and 64 mg N m(-2) d(-1)) rates in the harbor and from deep water, respectively. Amendment with NO3- enhanced DeNIT rates more than carbon amendment; however, DeNIT and NIT rates were inversely related, suggesting the two processes are decoupled in sediments. Average proportion of N2O released during DEA (23-54%) was greater than from DeNIT (0-41%). Nitrogen cycling rates were spatially and temporally variable, but we modeled how alterations to water depth and N-inputs may impact DeNIT rates. A large flood occurred in 2012 which temporarily altered water chemistry and sediment nitrogen cycling. Published by Elsevier BM, on behalf of International Association for Great Lakes Research. C1 [Bellinger, Brent J.; Jicha, Terri M.; Lehto, LaRae P.; Bolgrien, David W.; Angradi, Theodore R.; Pearson, Mark S.; Elonen, Colleen; Hill, Brian H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Seifert-Monson, Lindsey R.] Univ Minnesota, Grad Program Integrat Biosci, Duluth, MN 55812 USA. [Starry, Matthew A.] SRA Int Inc, Duluth, MN 55804 USA. RP Bellinger, BJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM bellinger.brent@epa.gov NR 55 TC 5 Z9 6 U1 8 U2 77 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD JUN PY 2014 VL 40 IS 2 BP 392 EP 403 DI 10.1016/j.jglr.2014.03.012 PG 12 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AI1TI UT WOS:000336637300019 ER PT J AU Sikdar, SK AF Sikdar, Subhas K. TI E-conversation with Professor Mahmoud El-Halwagi SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Editorial Material C1 US EPA, Cincinnati, OH 45268 USA. RP Sikdar, SK (reprint author), US EPA, Cincinnati, OH 45268 USA. EM sikdar.subhas@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD JUN PY 2014 VL 16 IS 5 BP 787 EP 790 DI 10.1007/s10098-014-0775-y PG 4 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AH8SN UT WOS:000336408600002 ER PT J AU Allen, CR Angeler, DG Garmestani, AS Gunderson, LH Holling, CS AF Allen, Craig R. Angeler, David G. Garmestani, Ahjond S. Gunderson, Lance H. Holling, C. S. TI Panarchy: Theory and Application SO ECOSYSTEMS LA English DT Article DE complex systems; discontinuities; novelty; regime; resilience; social-ecological systems; transformations ID CITY SIZE DISTRIBUTIONS; COMPLEX-SYSTEMS; REGIME SHIFTS; ECOLOGICAL RESILIENCE; FUNCTIONAL RICHNESS; RELATIVE RESILIENCE; TEMPORAL SCALES; SOCIAL-SYSTEMS; CLIMATE-CHANGE; CORAL-REEFS AB The concept of panarchy provides a framework that characterizes complex systems of people and nature as dynamically organized and structured within and across scales of space and time. It has been more than a decade since the introduction of panarchy. Over this period, its invocation in peer-reviewed literature has been steadily increasing, but its use remains primarily descriptive and abstract. Here, we discuss the use of the concept in the literature to date, highlight where the concept may be useful, and discuss limitations to the broader applicability of panarchy theory for research in the ecological and social sciences. Finally, we forward a set of testable hypotheses to evaluate key propositions that follow from panarchy theory. C1 [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, S-75007 Uppsala, Sweden. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Gunderson, Lance H.] Emory Univ, Dept Environm Studies, Atlanta, GA 30322 USA. [Holling, C. S.] Resilience Ctr, Nanaimo, BC, Canada. RP Allen, CR (reprint author), Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. EM allencr@unl.edu FU U.S. Geological Survey; Nebraska Game and Parks Commission; University of Nebraska-Lincoln; United States Fish and Wildlife Service; Wildlife Management Institute; August T. Larsson Foundation of the Swedish University of Agricultural Sciences; U.S. Geological Survey John Wesley Powell Center FX An earlier version of this manuscript was improved by comments from K. Nash, T. Spanbauer, and two anonymous reviewers. We also thank Bev Gunderson for graphics support. The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the U.S. Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska-Lincoln, the United States Fish and Wildlife Service and the Wildlife Management Institute. The views expressed herein are those of the authors and do not necessarily represent those of the United States Government or U.S. EPA. We gratefully acknowledge funding from the August T. Larsson Foundation of the Swedish University of Agricultural Sciences, and the U.S. Geological Survey John Wesley Powell Center for Analysis and Synthesis. NR 87 TC 33 Z9 36 U1 13 U2 118 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-9840 EI 1435-0629 J9 ECOSYSTEMS JI Ecosystems PD JUN PY 2014 VL 17 IS 4 BP 578 EP 589 DI 10.1007/s10021-013-9744-2 PG 12 WC Ecology SC Environmental Sciences & Ecology GA AH8OO UT WOS:000336397600002 ER PT J AU Ghio, AJ AF Ghio, A. J. TI Particle exposures and infections SO INFECTION LA English DT Review DE Particulate matter; Smoking; Quartz; Air pollution; Tuberculosis; Meningitis ID INDOOR AIR-POLLUTION; ENVIRONMENTAL TOBACCO-SMOKE; DIESEL EXHAUST PARTICLES; INVASIVE PNEUMOCOCCAL DISEASE; RESPIRATORY-TRACT INFECTION; RISK-FACTORS; CIGARETTE-SMOKING; PASSIVE SMOKING; WOOD SMOKE; MYCOBACTERIUM-TUBERCULOSIS AB Particle exposures increase the risk for human infections. Particles can deposit in the nose, pharynx, larynx, trachea, bronchi, and distal lung and, accordingly, the respiratory tract is the system most frequently infected after such exposure; however, meningitis also occurs. Cigarette smoking, burning of biomass, dust storms, mining, agricultural work, environmental tobacco smoke (ETS), wood stoves, traffic-related emissions, gas stoves, and ambient air pollution are all particle-related exposures associated with an increased risk for respiratory infections. In addition, cigarette smoking, burning of biomass, dust storms, mining, and ETS can result in an elevated risk for tuberculosis, atypical mycobacterial infections, and meningitis. One of the mechanisms for particle-related infections includes an accumulation of iron by surface functional groups of particulate matter (PM). Since elevations in metal availability are common to every particle exposure, all PM potentially contributes to these infections. Therefore, exposures to wood stove emissions, diesel exhaust, and air pollution particles are predicted to increase the incidence and prevalence of tuberculosis, atypical mycobacterial infections, and meningitis, albeit these elevations are likely to be small and detectable only in large population studies. Since iron accumulation correlates with the presence of surface functional groups and dependent metal coordination by the PM, the risk for infection continues as long as the particle is retained. Subsequently, it is expected that the cessation of exposure will diminish, but not totally reverse, the elevated risk for infection. C1 [Ghio, A. J.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Ghio, A. J.] Human Studies Facil, Chapel Hill, NC 27711 USA. RP Ghio, AJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM ghio.andy@epa.gov NR 110 TC 8 Z9 8 U1 4 U2 18 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0300-8126 EI 1439-0973 J9 INFECTION JI Infection PD JUN PY 2014 VL 42 IS 3 BP 459 EP 467 DI 10.1007/s15010-014-0592-6 PG 9 WC Infectious Diseases SC Infectious Diseases GA AH8NB UT WOS:000336393600002 PM 24488331 ER PT J AU Gordon, CJ Johnstone, AF Aydin, C Phillips, PM MacPhail, RC Kodavanti, UP Ledbetter, AD Jarema, KA AF Gordon, C. J. Johnstone, A. F. Aydin, C. Phillips, P. M. MacPhail, R. C. Kodavanti, U. P. Ledbetter, A. D. Jarema, K. A. TI Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity SO INHALATION TOXICOLOGY LA English DT Article DE Aging; air pollution; fever; hypothermia ID MEDIAL PREOPTIC AREA; BODY-TEMPERATURE; RESPONSES; SUSCEPTIBILITY; YOUNG AB Setting exposure standards for environmental pollutants may consider the aged as a susceptible population but the few published studies assessing susceptibility of the aged to air pollutants are inconsistent. Episodic ozone (O-3) is more reflective of potential exposures occurring in human populations and could be more harmful to the aged. This study used radiotelemetry to monitor heart rate (HR), core temperature (T-c) and motor activity (MA) in adult (9-12 months) and senescent (20-24 months) male, Brown Norway rats exposed to episodic O-3 (6 h/day of 1 ppm O-3 for 2 consecutive days/week for 13 weeks). Acute O-3 initially led to marked drops in HR and T-c. As exposures progressed each week, there was diminution in the hypothermic and bradycardic effects of O-3. Senescent rats were less affected than adults. Acute responses were exacerbated on the second day of O-3 exposure with adults exhibiting greater sensitivity. During recovery following 2 d of O-3, adult and senescent rats exhibited an elevated Tc and HR during the day but not at night, an effect that persisted for at least 48 h after O-3 exposure. MA was elevated in adults but not senescent rats during recovery from O-3. Overall, acute effects of O-3, including reductions in HR and T-c, were attenuated in senescent rats. Autonomic responses during recovery, included an elevation in T-c with a pattern akin to that of a fever and rise in HR that were independent of age. An attenuated inflammatory response to O-3 in senescent rats may explain the relatively heightened physiological response to O-3 in younger rats. C1 [Gordon, C. J.; Johnstone, A. F.; Phillips, P. M.; MacPhail, R. C.; Jarema, K. A.] US EPA, Toxic Assessment Div, Res Triangle Pk, NC 27711 USA. [Aydin, C.] Uludag Univ, Dept Physiol, Fac Vet Med, Bursa, Turkey. [Kodavanti, U. P.; Ledbetter, A. D.] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. RP Gordon, CJ (reprint author), US EPA, NHEERL, Toxic Assessment Div, MD B105-04, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov NR 30 TC 10 Z9 10 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JUN PY 2014 VL 26 IS 7 BP 380 EP 390 DI 10.3109/08958378.2014.905659 PG 11 WC Toxicology SC Toxicology GA AH8KX UT WOS:000336387800002 PM 24779854 ER PT J AU Ghio, AJ Soukup, JM Dailey, LA Richards, JH Duncan, KE Lehmann, J AF Ghio, Andrew J. Soukup, Joleen M. Dailey, Lisa A. Richards, Judy H. Duncan, Kelly E. Lehmann, James TI Iron decreases biological effects of ozone exposure SO INHALATION TOXICOLOGY LA English DT Article DE Air pollution; ferritin; free radicals; lung diseases; oxidants ID INDUCED AIRWAY HYPERRESPONSIVENESS; OXIDATIVE STRESS; EPITHELIAL-CELLS; SERUM FERRITIN; INCREASES; LUNG; RATS; HUMANS; INFLAMMATION; HOMEOSTASIS AB Context: Ozone (O-3) exposure is associated with a disruption of iron homeostasis and increased availability of this metal which potentially contributes to an oxidative stress and biological effects. Objective: We tested the postulate that increased concentrations of iron in cells, an animal model and human subjects would significantly impact the biological effects of O-3 exposure. Results: Exposure to 0.4 ppm O-3 for 5 h increased mRNA for both Superoxide Dismutase-1 (SOD1) and Cyclooxygenase-2 (COX2) in normal human bronchial epithelial (NHBE) cells. Pre-treatment of NHBE cells with 200 mu M ferric ammonium citrate (FAC) for 4 h diminished changes in both SOD1 and COX2 following O-3 exposure. mRNA transcript levels and associated protein release of the pro-inflammatory mediators IL-6 and IL-8 were increased by O-3 exposure of NHBE cells; changes in these endpoints after O-3 exposure were significantly decreased by FAC pre-treatment of the cells. Exposure of CD-1 mice to 2 ppm O-3 for 3 h significantly increased lavage indices of inflammation and airflow limitation. Pre-treatment of the animals with pharyngeal aspiration of FAC diminished the same endpoints. Finally, the mean loss of pulmonary function in 19 healthy volunteers exposed to 0.3ppm O-3 for 2 h demonstrated significant correlations with either their pre-exposure plasma ferritin or iron concentrations. Discussion and conclusion: We conclude that greater availability of iron after O-3 exposure does not augment biological effects. On the contrary, increased available iron decreases the biological effects of O-3 exposure in cells, animals and humans. C1 [Ghio, Andrew J.; Soukup, Joleen M.; Dailey, Lisa A.; Richards, Judy H.; Lehmann, James] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Duncan, Kelly E.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA. RP Ghio, AJ (reprint author), US EPA, Human Studies Div, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM ghio.andy@epa.gov NR 39 TC 3 Z9 3 U1 1 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JUN PY 2014 VL 26 IS 7 BP 391 EP 399 DI 10.3109/08958378.2014.908330 PG 9 WC Toxicology SC Toxicology GA AH8KX UT WOS:000336387800003 PM 24862973 ER PT J AU Schwindt, AR Winkelman, DL Keteles, K Murphy, M Vajda, AM AF Schwindt, Adam R. Winkelman, Dana L. Keteles, Kristen Murphy, Mark Vajda, Alan M. TI An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity SO JOURNAL OF APPLIED ECOLOGY LA English DT Article DE freshwater; endocrine disruption; North America; transgenerational; population ecology; fish; 17 alpha-ethynylestradiol; mesocosm; Pimephales promelas ID MINNOW PIMEPHALES-PROMELAS; PLATTE RIVER-BASIN; FATHEAD MINNOW; REPRODUCTIVE FAILURE; SYNTHETIC ESTROGEN; DANIO-RERIO; EXPOSURE; ZEBRAFISH; 17-ALPHA-ETHINYLESTRADIOL; BIODIVERSITY AB Increased need for water and projected declines in precipitation due to climate change could leave waterways increasingly dominated by wastewater effluent. Understanding how components of wastewater influence fish populations is necessary for effective conservation and management. Despite research demonstrating effects of oestrogens, such as 17 alpha-ethynylestradiol (EE2), on fish physiology and population failure, the generality of population responses is uncertain and the underlying mechanisms affecting population declines are unknown. EE2 is the steroid oestrogen in human contraceptive pills and has been measured up to 11ng L-1 in the environment. We identify disrupted population dynamics due to direct and transgenerational effects on survival and fecundity. We conducted a year-long study on three generations of fathead minnows Pimephales promelas Rafinesque in aquatic mesocosms and laboratory aquaria. We added environmentally relevant concentrations of EE2 daily using a static renewal, which approximates a pulsed exposure that fish experience in natural systems. EE2 (3 center dot 2ng L-1) reduced F0 male survival to 17% (48% lower than controls) and juvenile production by 40% compared to controls. F1 fish continuously exposed to EE2 failed to reproduce, and reproduction of the F1 transferred to clean water was 70-99% less than controls. F2 larval survival, exposed only as germ cells in their parents, was reduced by 51-97% compared to controls. The indirect effect on F2 survival suggests the possibility of transgenerational effects of EE2. Synthesis and applications. Our results suggest that fish populations exposed to environmentally relevant 17 alpha-ethynylestradiol (EE2) concentrations may not recover from exposure. Management of short-lived highly fecund fishes should be prioritized to protect fish from the embryo through gonadal differentiation. Reducing effluent will not be possible in many situations; hence, conservation of breeding and rearing habitat in unpolluted tributaries or reaches is needed. Additionally, resource managers could enhance habitat connectivity in rivers to facilitate immigration. Finally, investment in advanced wastewater processing technology should improve removal of bioactive chemicals such as EE2. Our results provide a baseline for regulatory agencies to consider when assessing the ecological effects of environmental oestrogens, and our approach to evaluating population-level effects could be widely applied to other contaminants. C1 [Schwindt, Adam R.] Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA. [Winkelman, Dana L.] Colorado State Univ, US Geol Survey, Dept Fish Wildlife & Conservat Biol, Colorado Cooperat Fish & Wildlife Res Unit, Ft Collins, CO 80523 USA. [Keteles, Kristen; Murphy, Mark] US EPA, Denver, CO 80202 USA. [Vajda, Alan M.] Univ Colorado, Dept Integrat Biol, Denver, CO 80217 USA. RP Schwindt, AR (reprint author), Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA. EM ar.schwindt@gmail.com FU Colorado Division of Parks and Wildlife; US EPA Region [8]; US EPA Office of Research and Development, NHEERL, Cincinnati, OH; Colorado Cooperative Fish and Wildlife Research Unit; United States EPA [95785501] FX We thank Chris Myrick, David Pratt, Dane Whicker, Nick Shannon, Ashley Ficke, William Clements, Jim Lazorchak, The US EPA Region 8 Laboratory, and Gabriele Engler, for technical assistance. David Walters, Dan Villeneuve, and Jim Lazorchak and three anonymous reviewers provided helpful comments on the manuscript. Funding: Colorado Division of Parks and Wildlife; US EPA Region 8; US EPA Office of Research and Development, NHEERL, Cincinnati, OH; and The Colorado Cooperative Fish and Wildlife Research Unit. Although the research described in this publication has been funded in part by the United States EPA through Interagency Agreement #95785501 to the USGS Colorado Fish and Wildlife Cooperative Research Unit, it has not been subject to the Agency's peer-review policy and does not necessarily reflect the views of the EPA. Any use of trade, firm or product names is for descriptive purposes only and does not imply endorsement by the US Government. NR 35 TC 16 Z9 17 U1 17 U2 98 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8901 EI 1365-2664 J9 J APPL ECOL JI J. Appl. Ecol. PD JUN PY 2014 VL 51 IS 3 BP 582 EP 591 DI 10.1111/1365-2664.12237 PG 10 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AH2PA UT WOS:000335962200004 ER PT J AU Luo, P Takara, K Apip He, B Nover, D AF Luo, P. Takara, K. Apip He, B. Nover, D. TI Palaeoflood simulation of the Kamo River basin using a grid- cell distributed rainfall run- off model SO JOURNAL OF FLOOD RISK MANAGEMENT LA English DT Article DE CDRMV3; historical documents; Kamo River; palaeoflood simulation; PLUR ID FLOOD FREQUENCY; LATE HOLOCENE; LAND-USE; JAPAN; HYDROLOGY; MANAGEMENT; IMPACTS AB Land-use change and human activities have dramatic implications for water resources, especially through impacts on hydrology and water quality. We characterise the impact of land-use change on floods through the reconstruction of palaeoflood events and the estimation of discharge during extreme rainfall events under the historical environment using the grid-Cell Distributed Rainfall Run-off Model Version 3 (CDRMV3). Historical land use maps were digitised using the Palaeoland-Use Reconstruction (PLUR) programme as the input data for CDRMV3. Palaeoflood simulations show the delay and the reduction of the peak discharge under 1902 land use in the Kamo River basin because of increases in coverage of forest and paddy fields compared with 1976 land use. Lower discharge and earlier peak discharge time are estimated under historical land use and compared with conditions under present land use. The results of the palaeoflood simulations under extreme rainfall events create a better understanding of palaeoenvironmental conditions and their potential impact on flood management while suggesting important implications for resource management under land use and climate change. C1 [Luo, P.; Takara, K.; Apip; He, B.] Kyoto Univ, DPRI, Uji, Kyoto 6110011, Japan. [He, B.] Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Uji, Kyoto 6110011, Japan. [Nover, D.] US EPA, Global Change Res Program, Washington, DC 20460 USA. RP Luo, P (reprint author), Kyoto Univ, DPRI, Uji, Kyoto 6110011, Japan. EM robertluoping@flood.dpri.kyoto-u.ac.jp FU Japan Society for the Promotion of Science (JSPS) [P12055]; JSPS KAKENHI [24.02055] FX This study was supported by the Postdoctoral fellowship of Japan Society for the Promotion of Science (JSPS): P12055; JSPS KAKENHI Grant Number 24.02055; Designing Local Frameworks for Integrated Water Resources Management at the Research Institute for Humanity and Nature; the Kyoto University Global COE programme on 'Sustainability/Survivability Science for a Resilient Society Adaptable to Extreme Weather Conditions 2009-2014; and InterGraduate School Program for Sustainable Development and Survivable Societies (GSS), MEXT Program for Leading Graduate Schools 2011-2018. The authors are grateful for their support. We also thank Mr Pedro Luiz Borges Chaffe and Mr Netrananda Sahu for providing comments on this paper. NR 41 TC 7 Z9 7 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1753-318X J9 J FLOOD RISK MANAG JI J. Flood Risk Manag. PD JUN PY 2014 VL 7 IS 2 BP 182 EP 192 DI 10.1111/jfr3.12038 PG 11 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AG4PD UT WOS:000335401600009 ER PT J AU Zhang, Y Shuster, W AF Zhang, Yu Shuster, William TI Impacts of Spatial Distribution of Impervious Areas on Runoff Response of Hillslope Catchments: Simulation Study SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Hydrology; Urban development; Runoff; Simulation; Slopes; Catchments; Spatial distribution; Impervious; Hydrology; Runoff; Simulation ID PEAK DISCHARGES; FLOOD RESPONSE; RAINFALL; SYSTEMS; URBANIZATION; INFILTRATION; OPTIMIZATION; VARIABILITY; BASIN AB This study analyzes variations in the model-projected changes in catchment runoff response after urbanization that stem from variations in the spatial distribution of impervious areas, interevent differences in temporal rainfall structure, and antecedent soil moisture (ASM). In this work, an ensemble of hypothetical imperviousness scenarios created for two small (<1ha) watersheds were incorporated into the gridded surface subsurface hydrologic analysis (GSSHA) model, which was calibrated against 41 runoff events under natural conditions. Each event was resimulated for each imperviousness scenario. Variations in the model-projected changes in runoff were characterized and related to temporal rainfall dispersion, ASM, and two metrics: (1)proximity of imperviousness from the outlet, and (2)normalized number of downstream pervious elements. Key findings include the following: First, interscenario variations in the simulated runoff were relatively subdued on an event-mean basis but were much wider for individual events. For example, the coefficient of variation (CV) was less than 7.8% for runoff peak but was beyond 20% for certain events. Second, the rate of increase in simulated runoff peaks with elevated imperviousness tends to be lower for events with higher temporal rainfall dispersion and ASM, with one of the largest events exhibiting the slowest rate of increase. Third, both metrics were found to be negatively correlated with simulated runoff depth. These findings point to the possibility of refining the model projection by incorporating indicators of overall locations of impervious areas, rainfall dispersion, and soil moisture conditions. C1 [Zhang, Yu; Shuster, William] US EPA, Natl Risk Assessment Lab, Cincinnati, OH 45268 USA. RP Zhang, Y (reprint author), US EPA, Natl Risk Assessment Lab, 26 Martin Luther King Dr, Cincinnati, OH 45268 USA. EM yu.zhang@noaa.gov; shuster.william@epa.gov NR 30 TC 11 Z9 11 U1 3 U2 46 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUN 1 PY 2014 VL 19 IS 6 BP 1089 EP 1100 DI 10.1061/(ASCE)HE.1943-5584.0000905 PG 12 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AH6QE UT WOS:000336254900005 ER PT J AU Klinefelter, GR Laskey, JW Amann, RP AF Klinefelter, G. R. Laskey, J. W. Amann, R. P. TI Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: Implications for men SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE Isolated Leydig cells; Statins; LH-stimulation; Testosterone production; Progestin ID COA REDUCTASE INHIBITORS; COENZYME-A REDUCTASE; INVITRO PERFUSED TESTES; CHOLESTEROL-SYNTHESIS; STEROL SYNTHESIS; HYPOCHOLESTEROLEMIC ACTIVITY; SELECTIVE-INHIBITION; PRAVASTATIN SODIUM; TISSUE SELECTIVITY; TESTICULAR TISSUE AB Statin drugs lower blood cholesterol by inhibiting hepatic 3-hydroxy-3-methylglutaryl-Coenzyme-A reductase. Statins are known to inhibit sterol production in the testis, but effect of statins on testosterone production has not been studied critically in vitro and clinical data are controversial. We measured 18-h testosterone production in vitro, using highly purified rat Leydig cells exposed to atorvastatin, mevastatin, or simvastatin and also determined if statin-induced inhibition of testosterone production could be bypassed with substrate distal to cholesterol. Statins had no effect on testosterone production during culture without LH. However, with 10 ng/mL LH, testosterone production was >= 12-fold higher and markedly inhibited (-40%) by >= 0.31.mu M statin. Leydig cells provided sub-saturating pregnenolone or progesterone to bypass the site of statin action, maintained LH-stimulated testosterone production at or above amounts observed with LH stimulation and no statin. Pregnenolone resulted in greater testosterone production, but LH responsiveness was lost. With progesterone, LH responsiveness was maintained. Published by Elsevier Inc. C1 [Klinefelter, G. R.; Laskey, J. W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div,Reprod Toxicol Facil, Durham, NC 27713 USA. [Amann, R. P.] Colorado State Univ, Anim Reprod & Biotechnol Lab, Ft Collins, CO 80523 USA. RP Klinefelter, GR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div,Reprod Toxicol Facil, Durham, NC 27713 USA. EM klinefelter.gary@epa.gov NR 54 TC 7 Z9 8 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD JUN PY 2014 VL 45 BP 52 EP 58 DI 10.1016/j.reprotox.2013.12.010 PG 7 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA AH8VH UT WOS:000336415800008 PM 24462564 ER PT J AU Adhikari, A Kettleson, EM Vesper, S Kumar, S Popham, DL Schaffer, C Indugula, R Chatterjee, K Allam, KK Grinshpun, SA Reponen, T AF Adhikari, Atin Kettleson, Eric M. Vesper, Stephen Kumar, Sudhir Popham, David L. Schaffer, Christopher Indugula, Reshmi Chatterjee, Kanistha Allam, Karteek K. Grinshpun, Sergey A. Reponen, Tiina TI Dustborne and airborne Gram-positive and Gram-negative bacteria in high versus low ERMI homes SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Indoor air quality; Bacteria; Mold; ERMI; Endotoxin; Muramic acid ID DAMAGED BUILDING-MATERIALS; RELATIVE MOLDINESS INDEX; MOLECULAR CHARACTERIZATION; INDOOR ENVIRONMENT; PCR ANALYSIS; DUST; FUNGI; ENDOTOXIN; ASTHMA; DIVERSITY AB The study aimed at investigating Gram-positive and Gram-negative bacteria in moldy and non-moldy homes, as defined by the home's Environmental Relative Moldiness Index (ERMI) value. The ERMI values were determined from floor dust samples in 2010 and 2011 and homes were classified into low (<5) and high (>5) ERMI groups based on the average ERMI values as well as 2011 ERMI values. Dust and air samples were collected from the homes in 2011 and all samples were analyzed for Gram-positive and Gram-negative bacteria using QPCR assays, endotoxin by the LAL assay, and N-acetyl-muramic acid using HPLC. In addition, air samples were analyzed for culturable bacteria. When average ERMI values were considered, the concentration and load of Gram-positive bacteria determined with QPCR in house dust, but not air, were significantly greater in high ERMI homes than in low ERMI homes. Furthermore, the concentration of endotoxin, but not muramic acid, in the dust was significantly greater in high ERMI than in low ERMI homes. In contrast, when ERMI values of 2011 were considered, Gram-negative bacteria determined with QPCR in air, endotoxin in air, and muramic acid in dust were significantly greater in high ERMI homes. The results suggest that both short-term and long-term mold contamination in homes could be linked with the bacterial concentrations in house dust, however, only the current mold status was associated with bacterial concentrations in air. Although correlations were found between endotoxin and Gram-negative bacteria as well as between muramic acid and Gram-positive bacteria in the entire data set, diverging associations were observed between the different measures of bacteria and the home moldiness. It is likely that concentrations of cells obtained by QPCR and concentrations of cell wall components are not equivalent and represent too broad categories to understand the bacterial composition and sources of the home microbiota. (C) 2014 Elsevier B.V. All rights reserved. C1 [Adhikari, Atin; Kettleson, Eric M.; Kumar, Sudhir; Schaffer, Christopher; Indugula, Reshmi; Chatterjee, Kanistha; Allam, Karteek K.; Grinshpun, Sergey A.; Reponen, Tiina] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Vesper, Stephen] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Popham, David L.] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA. RP Adhikari, A (reprint author), Univ Cincinnati, Dept Environm Hlth, 3223 Eden Ave,POB 670056, Cincinnati, OH 45267 USA. EM atin.adhikari@uc.edu RI Popham, David/F-8066-2015 OI Popham, David/0000-0002-2614-143X FU Healthy Homes Technical Studies Program of the U.S. Department of Housing and Urban Development (HUD) [OHLHH0199-09]; HUD Grant [OHLHH0162-07]; National Institute of Environmental Health Sciences (NIEHS) [T32ES010957-11]; NIEHS Grant [ES11170] FX This study was supported by Grant No. OHLHH0199-09 from the Healthy Homes Technical Studies Program of the U.S. Department of Housing and Urban Development (HUD). We also acknowledge a partial support from the HUD Grant OHLHH0162-07 and the National Institute of Environmental Health Sciences (NIEHS) Grant No. T32ES010957-11 awarded to the University of Cincinnati. The CCAAPS birth cohort study was supported by NIEHS Grant ES11170. Technical assistance from Dr. Umesh Singh, Mrs. Sewwandi Rathnayake, Mrs. Moumita Ghosh, Mrs. Sonam Gupta, and Mr. Lev Lazinskiy during air and dust sampling is graciously acknowledged. The authors are also thankful to Drs. William G. Lindsley and Bean T. Chen at NIOSH for providing the NIOSH two-stage cyclones. NR 33 TC 2 Z9 2 U1 3 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUN 1 PY 2014 VL 482 BP 92 EP 99 DI 10.1016/j.scitotenv.2014.02.110 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA AG7UU UT WOS:000335625100011 PM 24642096 ER PT J AU Shao, Y Yang, YJ Jiang, LJ Yu, TC Shen, C AF Shao, Yu Yang, Y. Jeffrey Jiang, Lijie Yu, Tingchao Shen, Cheng TI Experimental testing and modeling analysis of solute mixing at water distribution pipe junctions SO WATER RESEARCH LA English DT Article DE Cross junctions; Double-Tee junctions; Solute mixing; Drinking water distribution; Water quality modeling ID CONTAMINATION WARNING SYSTEMS; CROSS JUNCTIONS; FLOW; NETWORKS AB Flow dynamics at a pipe junction controls particle trajectories, solute mixing and concentrations in downstream pipes. The effect can lead to different outcomes of water quality modeling and, hence, drinking water management in a distribution network. Here we have investigated solute mixing behavior in pipe junctions of five hydraulic types, for which flow distribution factors and analytical equations for network modeling are proposed. First, based on experiments, the degree of mixing at a cross is found to be a function of flow momentum ratio that defines a junction flow distribution pattern and the degree of departure from complete mixing. Corresponding analytical solutions are also validated using computational-fluid-dynamics (CFD) simulations. Second, the analytical mixing model is further extended to double-Tee junctions. Correspondingly the flow distribution factor is modified to account for hydraulic departure from a cross configuration. For a double-Tee(A) junction, CFD simulations show that the solute mixing depends on flow momentum ratio and connection pipe length, whereas the mixing at double-Tee(B) is well represented by two independent single-Tee junctions with a potential water stagnation zone in between. Notably, double-Tee junctions differ significantly from a cross in solute mixing and transport. However, it is noted that these pipe connections are widely, but incorrectly, simplified as cross junctions of assumed complete solute mixing in network skeletonization and water quality modeling. For the studied pipe junction types, analytical solutions are proposed to characterize the incomplete mixing and hence may allow better water quality simulation in a distribution network. Published by Elsevier Ltd. C1 [Shao, Yu; Jiang, Lijie; Yu, Tingchao; Shen, Cheng] Zhejiang Univ, Dept Civil Engn, Hangzhou 310058, Zhejiang, Peoples R China. [Shao, Yu] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Yang, YJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM yang.jeff@epa.gov FU National Natural Science Foundation of China [51208457] FX The authors wish to thank two anonymous reviewers for their constructive comments, and to acknowledge the support by the National Natural Science Foundation of China (No. 51208457). Experiments were carried out at Zhejiang University, China. The research described herein, a part of US EPA Water Resources Adaptation Program (WRAP), has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. NR 31 TC 6 Z9 6 U1 5 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD JUN 1 PY 2014 VL 56 BP 133 EP 147 DI 10.1016/j.watres.2014.02.053 PG 15 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AH4OZ UT WOS:000336109200013 PM 24675269 ER PT J AU Hines, SA Chappie, DJ Lordo, RA Miller, BD Janke, RJ Lindquist, HA Fox, KR Ernst, HS Taft, SC AF Hines, Stephanie A. Chappie, Daniel J. Lordo, Robert A. Miller, Brian D. Janke, Robert J. Lindquist, H. Alan Fox, Kim R. Ernst, Hiba S. Taft, Sarah C. TI Assessment of relative potential for Legionella species or surrogates inhalation exposure from common water uses SO WATER RESEARCH LA English DT Article DE Legionellosis; Legionella species; Microbial exposure assessment; Inhalation; Drinking water ID MICROBIAL RISK-ASSESSMENT; LEGIONNAIRES-DISEASE; ASSESSMENT MODEL; TAP WATER; HOME HUMIDIFIERS; SHOWER WATER; PNEUMOPHILA; AEROSOLS; DEVICES; TRANSMISSION AB The Legionella species have been identified as important waterborne pathogens in terms of disease morbidity and mortality. Microbial exposure assessment is a tool that can be utilized to assess the potential of Legionella species inhalation exposure from common water uses. The screening-level exposure assessment presented in this paper developed emission factors to model aerosolization, quantitatively assessed inhalation exposures of aerosolized Legionella species or Legionella species surrogates while evaluating two generalized levels of assumed water concentrations, and developed a relative ranking of six common in-home uses of water for potential Legionella species inhalation exposure. Considerable variability in the calculated exposure dose was identified between the six identified exposure pathways, with the doses differing by over five orders of magnitude in each of the evaluated exposure scenarios. The assessment of exposure pathways that have been epidemiologically associated with legionellosis transmission (ultrasonic and cool mist humidifiers) produced higher estimated inhalation exposure doses than pathways where epidemiological evidence of transmission has been less strong (faucet and shower) or absent (toilets and therapy pool). With consideration of the large uncertainties inherent in the exposure assessment process used, a relative ranking of exposure pathways from highest to lowest exposure doses was produced using culture-based measurement data and the assumption of constant water concentration across exposure pathways. In this ranking, the ultrasonic and cool mist humidifier exposure pathways were estimated to produce the highest exposure doses, followed by the shower and faucet exposure pathways, and then the toilet and therapy pool exposure pathways. Published by Elsevier Ltd. C1 [Hines, Stephanie A.; Chappie, Daniel J.; Lordo, Robert A.; Miller, Brian D.] Battelle Mem Inst, Columbus, OH 43201 USA. [Janke, Robert J.; Lindquist, H. Alan; Fox, Kim R.; Ernst, Hiba S.; Taft, Sarah C.] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. RP Taft, SC (reprint author), US EPA, Natl Homeland Secur Res Ctr, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM taft.sarah@epa.gov FU U.S. Environmental Protection Agency (EPA) [DW97922089]; Defense Technical Information Center; Nuclear Defense Information Analysis Center [SP0-700-D-3180] FX The U.S. Environmental Protection Agency (EPA) funded and managed this research performed by Battelle and described herein under Interagency Agreement DW97922089 with the Defense Technical Information Center, and in turn through Battelle Chemical, Biological, Radiological, and Nuclear Defense Information Analysis Center Contract SP0-700-D-3180. It has been subjected to the Agency's administrative review and approved for publication. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 52 TC 7 Z9 7 U1 1 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD JUN 1 PY 2014 VL 56 BP 203 EP 213 DI 10.1016/j.watres.2014.02.013 PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AH4OZ UT WOS:000336109200020 PM 24681377 ER PT J AU Yadav, JSS Bezawada, J Elharche, S Yan, S Tyagi, RD Surampalli, RY AF Yadav, J. S. S. Bezawada, J. Elharche, S. Yan, S. Tyagi, R. D. Surampalli, R. Y. TI Simultaneous single-cell protein production and COD removal with characterization of residual protein and intermediate metabolites during whey fermentation by K-marxianus SO BIOPROCESS AND BIOSYSTEMS ENGINEERING LA English DT Article DE Single-cell protein; Cheese whey; COD; Whey protein; Intermediate metabolites; Cell recycle ID CHEESE WHEY; BIOTECHNOLOGICAL UTILIZATION; GOAT WHEY; BIOMASS; BATCH; PHYSIOLOGY; FRAGILIS; CULTURES; GROWTH AB Cheese whey fermentation with Kluyveromyces marxianus was carried out at 40 A degrees C and pH 3.5 to examine simultaneous single-cell protein production and chemical oxygen demand (COD) removal, determine the fate of soluble whey protein and characterize intermediate metabolites. After 36 h of batch fermentation, the biomass concentration increased from 2.0 to 6.0 g/L with 55 % COD reduction (including protein), whereas soluble whey protein concentration decreased from 5.6 to 4.1 g/L. It was confirmed through electrophoresis (SDS-PAGE) that the fermented whey protein was different from native whey protein. HPLC and GC-MS analysis revealed a change in composition of organic compounds post-fermentation. High inoculum concentration in batch fermentation resulted in an increase in biomass concentration from 10.3 to 15.9 g/L with 80 % COD reduction (including protein) within 36 h with residual protein concentration of 4.5 g/L. In third batch fermentation, the biomass concentration increased from 7.3 to 12.4 g/L with 71 % of COD removal and residual protein concentration of 4.3 g/L after 22 h. After 22 h, the batch process was shifted to a continuous process with cell recycle, and the steady state was achieved after another 60 h with biomass yield of 0.19 g biomass/g lactose and productivity of 0.26 g/L h. COD removal efficiency was 78-79 % with residual protein concentration of 3.8-4.2 g/L. The aerobic continuous fermentation process with cell recycle could be applied to single-cell protein production with substantial COD removal at low pH and high temperature from cheese whey. C1 [Yadav, J. S. S.; Bezawada, J.; Yan, S.; Tyagi, R. D.] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ G1K 9A9, Canada. [Elharche, S.] Inst Super Hautes Etud Dev Durable, Rabat, Morocco. [Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA. RP Tyagi, RD (reprint author), Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, 490 Couronne, Quebec City, PQ G1K 9A9, Canada. EM tyagi@ete.inrs.ca FU Natural Sciences and Engineering Research Council of Canada [A4984, RDCPJ379601-08]; Natural Sciences and Engineering Research Council of Canada (Canada Research Chair) FX The authors are sincerely thankful to the Natural Sciences and Engineering Research Council of Canada (Grant A4984, RDCPJ379601-08, and Canada Research Chair) for their financial support. NR 41 TC 8 Z9 8 U1 4 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-7591 EI 1615-7605 J9 BIOPROC BIOSYST ENG JI Bioprocess. Biosyst. Eng. PD JUN PY 2014 VL 37 IS 6 BP 1017 EP 1029 DI 10.1007/s00449-013-1072-6 PG 13 WC Biotechnology & Applied Microbiology; Engineering, Chemical SC Biotechnology & Applied Microbiology; Engineering GA AG8KA UT WOS:000335666100005 PM 24185705 ER PT J AU Hansen, VD Nestlerode, JA AF Hansen, Virginia D. Nestlerode, Janet A. TI Carbon sequestration in wetland soils of the northern Gulf of Mexico coastal region SO WETLANDS ECOLOGY AND MANAGEMENT LA English DT Article DE Gulf of Mexico; Coastal wetlands; Carbon ID RAPIDLY SUBSIDING WETLAND; VERTICAL ACCRETION; FORESTED WETLAND; ESTUARINE MARSH; ORGANIC-CARBON; TIDAL MARSHES; CANAL IMPACTS; ACCUMULATION; LOUISIANA; SEDIMENTATION AB Coastal wetlands play an important but complex role in the global carbon cycle, contributing to the ecosystem service of greenhouse gas regulation through carbon sequestration. Although coastal wetlands occupy a small percent of the total US land area, their potential for carbon storage, especially in soils, often exceeds that of other terrestrial ecosystems. More than half of the coastal wetlands in the US are located in the northern Gulf of Mexico, yet these wetlands continue to be degraded at an alarming rate, resulting in a significant loss of stored carbon and reduction in capacity for carbon sequestration. We provide estimates of surface soil carbon densities for wetlands in the northern Gulf of Mexico coastal region, calculated from field measurements of bulk density and soil carbon content in the upper 10-15 cm of soil. We combined these estimates with soil accretion rates derived from the literature and wetland area estimates to calculate surface soil carbon pools and accumulation rates. Wetlands in the northern Gulf of Mexico coastal region potentially store 34-47 Mg C ha(-1) and could potentially accumulate 11,517 Gg C year(-1). These estimates provide important information that can be used to incorporate the value of wetlands in the northern Gulf of Mexico coastal region in future wetland management decisions related to global climate change. Estimates of carbon sequestration potential should be considered along with estimates of other ecosystem services provided by wetlands in the northern Gulf of Mexico coastal region to strengthen and enhance the conservation, sustainable management, and restoration of these important natural resources. C1 [Hansen, Virginia D.; Nestlerode, Janet A.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Hansen, VD (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM hansen.virginia@epa.gov FU U.S. Environmental Protection Agency FX We thank Alex Almario (USEPA), Tom Heitmuller (USGS-retired), Darrin Dantin (US EPA), Pat O'Donnell (Rookery Bay National Estuarine Research Reserve), and the staff from the Louisiana Department of Natural Resources Coastal Restoration Division, USGS-NWRC Coastal Restoration Field Station (Baton Rouge) for conducting the field work to assess the condition of wetlands in the northern Gulf of Mexico coastal region in 2007 and 2008. Sincere appreciation is also given to Amanda Nahlik, Matthew Harwell, and the anonymous peer reviewers for their insightful comments and recommendations to improve this manuscript. The information in this document has been funded by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U. S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This is contribution number 1444 from the U. S. EPA, Office of Research and Development, National Health and Environmental Effects Laboratory, Gulf Ecology Division. NR 60 TC 11 Z9 11 U1 13 U2 97 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0923-4861 EI 1572-9834 J9 WETL ECOL MANAG JI Wetl. Ecol. Manag. PD JUN PY 2014 VL 22 IS 3 BP 289 EP 303 DI 10.1007/s11273-013-9330-6 PG 15 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AH1VF UT WOS:000335908600006 ER PT J AU Liu, XY Guo, ZS Roache, NF AF Liu, Xiaoyu Guo, Zhishi Roache, Nancy F. TI Experimental method development for estimating solid-phase diffusion coefficients and material/air partition coefficients of SVOCs SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Semivolatile organic compounds; Polychlorinated biphenyls; Solid-phase diffusion coefficient; Material/air partition coefficient; Chamber testing; Mass transfer modeling ID SEMIVOLATILE ORGANIC-COMPOUNDS; LAYER BUILDING-MATERIALS; PREDICTING EMISSIONS; INDOOR ENVIRONMENTS; VOLATILE; FORMALDEHYDE; SORPTION; EXPOSURE; VOCS AB The solid-phase diffusion coefficient (D-m) and material/air partition coefficient (K-ma) are key parameters for characterizing the sources and transport of semivolatile organic compounds (SVOCs) in the indoor environment. In this work, a new experimental method was developed to estimate parameters D-m and K-ma. The SVOCs chosen for study were polychlorinated biphenyl (PCB) congeners, including PCB-52, PCB-66, PCB-101, PCB-110, and PCB-118. The test materials included polypropylene, high density polyethylene, low density polyethylene, polytetrafluoroethylene, polyether ether ketone, glass, stainless steel and concrete. Two 53-L environmental chambers were connected in series, with the relatively stable SVOCs source in the source chamber and the test materials, made as small "buttons", in the test chamber. Prior to loading the test chamber with the test materials, the test chamber had been dosed with SVOCs for 12 days to "coat" the chamber walls. During the tests, the material buttons were removed from the test chamber at different exposure times to determine the amount of SVOC absorbed by the buttons. SVOC concentrations at the inlet and outlet of the test chamber were also monitored. The data were used to estimate the partition and diffusion coefficients by fitting a sink model to the experimental data. The parameters obtained were employed to predict the accumulation of SVOCs in the sink materials using an existing mass transfer model. The model prediction agreed reasonably well with the experimental data. Published by Elsevier Ltd. C1 [Liu, Xiaoyu; Guo, Zhishi] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Roache, Nancy F.] ARCADIS US Inc, Durham, NC 27713 USA. RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM liu.xiaoyu@epa.gov FU U.S. Environmental Protection Agency (EPA), through its Office of Research and Development (ORD) FX The U.S. Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), funded the research described herein. It has not been subjected to EPA peer review and therefore does not necessarily reflect the views of EPA, and no official endorsement should be inferred. NR 37 TC 15 Z9 15 U1 2 U2 40 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD JUN PY 2014 VL 89 BP 76 EP 84 DI 10.1016/j.atmosenv.2014.02.021 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AH1IT UT WOS:000335874500009 ER PT J AU Nissenson, P Wingen, LM Hunt, SW Finlayson-Pitts, BJ Dabdub, D AF Nissenson, Paul Wingen, Lisa M. Hunt, Sherri W. Finlayson-Pitts, Barbara J. Dabdub, Donald TI Rapid formation of molecular bromine from deliquesced NaBr aerosol in the presence of ozone and UV light SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Bromide oxidation; Sensitivity analysis; Sea-salt aerosol; Aerosol modeling; Interface chemistry ID MARINE BOUNDARY-LAYER; SEA-SALT AEROSOL; PHASE CHEMICAL MECHANISM; TROPICAL ATLANTIC-OCEAN; HETEROGENEOUS REACTION; POLAR SUNRISE; UNCERTAINTY ANALYSIS; HALOGEN ACTIVATION; ROOM-TEMPERATURE; DEAD-SEA AB The formation of gas-phase bromine from aqueous sodium bromide aerosols is investigated through a combination of chamber experiments and chemical kinetics modeling. Experiments show that Br-2(g) is produced rapidly from deliquesced NaBr aerosols in the presence of OH radicals produced by ozone irradiated by UV light. The mechanisms responsible for the "bromine explosion" are examined using a comprehensive chemical kinetics Model of Aqueous, Gaseous, and Interfacial Chemistry (MAGIC). A sensitivity analysis on the model confirms that a complex mechanism involving gas-phase chemistry, aqueous-phase chemistry, and mass transfer is responsible for most of the observed bromine. However, the rate-limiting steps in the bromine explosion pathway vary, depending on the availability of ozone and bromide in the system. Interface reactions, an important source of bromine production under dark conditions, account for only a small fraction of total bromine under irradiation. Simulations performed with gaseous ozone and aerosol bromide concentrations typical of the marine boundary layer also show Br-2(g) production, with BrO(g) and HOBr(g) as the dominant Br-containing products through this mechanism. Aerosol bromide is depleted after several hours of daylight, with photolysis of BrO(g) and HOBr(g) becoming major sources of Br atoms that continue generating Br-2(g) after aerosol bromide is depleted. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Nissenson, Paul] Calif State Polytech Univ Pomona, Dept Mech Engn, Pomona, CA 91768 USA. [Wingen, Lisa M.; Finlayson-Pitts, Barbara J.] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA. [Hunt, Sherri W.] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA. [Dabdub, Donald] Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92697 USA. RP Finlayson-Pitts, BJ (reprint author), Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA. EM bjfinlay@uci.edu; ddabdub@uci.edu FU National Science Foundation (NSF) [CHE-0909227]; Department of Energy (DOE) [ER62578] FX The authors would like to thank Lee-Huang Chen for his assistance in processing and organizing data from the sensitivity and uncertainty analyses. This work was funded in part by the National Science Foundation (NSF Grant CHE-0909227) and the Department of Energy (DOE Grant ER62578). We are grateful to James N. Pitts Jr. for helpful discussions and comments on the manuscript. NR 106 TC 3 Z9 3 U1 6 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD JUN PY 2014 VL 89 BP 491 EP 506 DI 10.1016/j.atmosenv.2014.02.056 PG 16 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AH1IT UT WOS:000335874500052 ER PT J AU Jing, H Mezgebe, B Hassan, AA Sahle-Demessie, E Sorial, GA Bennett-Stamper, C AF Jing, Hengye Mezgebe, Bineyam Hassan, Ashraf Aly Sahle-Demessie, Endalkachew Sorial, George A. Bennett-Stamper, Christina TI Experimental and modeling studies of sorption of ceria nanoparticle on microbial biofilms SO BIORESOURCE TECHNOLOGY LA English DT Article DE Microbial biofilm; Nanoparticles; Nano-CeO2; Sorption kinetics; Confocal laser microscopy ID EXTRACELLULAR POLYMERIC SUBSTANCES; OXIDE NANOPARTICLES; ACTIVATED SLUDGES; HETEROGENEITY; FIBROBLASTS; PARTICLES; DIFFUSION; CERAMICS; ADHESION; DIOXIDE AB This study focuses on the interaction of ceria nanoparticles (CeO2-NPs) with Pseudomonas fluorescens and Mycobacterium smegmatis biofilms. Confocal laser microscopy and transmission electron microscopy determined the distribution of NPs in the complex structures of biofilm at molecular levels. Visual data showed that most of the adsorption takes place on the bacterial cell walls and spores. The interaction of nanoparticles (NPs) with biofilms reached equilibrium after the initial high adsorption rate regardless of biofilm heterogeneity and different nanoparticle concentrations in the bulk liquid. Physical processes may dominate this sorption phenomenon. Pseudo first order sorption kinetics was used to estimate adsorption and desorption rate of CeO2-NPs onto biofilms. When biofilms got exposed to CeO2-NPs, a self-protecting mechanism was observed. Cells moved away from the bulk solution in the biofilm matrix, and portions of biofilm outer layer were detached, hence releasing some CeO2-NPs back to the bulk phase. Published by Elsevier Ltd. C1 [Jing, Hengye; Mezgebe, Bineyam; Sorial, George A.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn Program, Cincinnati, OH USA. [Hassan, Ashraf Aly; Sahle-Demessie, Endalkachew; Bennett-Stamper, Christina] US EPA, NRMRL, Off Res & Dev, Cincinnati, OH 45268 USA. RP Sahle-Demessie, E (reprint author), US EPA, NRMRL, Off Res & Dev, Cincinnati, OH 45268 USA. EM sahle-demessie.endalkachew@epa.gov OI Jing, Hengye/0000-0002-8593-4659 NR 36 TC 11 Z9 15 U1 2 U2 44 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0960-8524 EI 1873-2976 J9 BIORESOURCE TECHNOL JI Bioresour. Technol. PD JUN PY 2014 VL 161 BP 109 EP 117 DI 10.1016/j.biortech.2014.03.015 PG 9 WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA AG5CF UT WOS:000335436000014 PM 24690581 ER PT J AU Yee, SH Dittmar, JA Oliver, LM AF Yee, Susan H. Dittmar, John A. Oliver, Leah M. TI Comparison of methods for quantifying reef ecosystem services: A case study mapping services for St. Croix, USVI SO ECOSYSTEM SERVICES LA English DT Article DE Coral reef; Ecological integrity; Fishing; Natural products; Recreation; Shoreline protection ID GREAT-BARRIER-REEF; FISH SPECIES RICHNESS; CORAL-REEF; HABITAT COMPLEXITY; SEAGRASS BEDS; MANGROVES; MANAGEMENT; PHARMACEUTICALS; CONNECTIVITY; PERCEPTIONS AB A key challenge in evaluating coastal and watershed management decisions is that monitoring efforts are largely focused On reef condition, yet stakeholder concerns may be more appropriately quantified by social and economic metrics. There is an urgent need for predictive models to quantitatively link ecological condition of coral reefs to provisioning of reef ecosystem goods and services. We investigated and compared a number of existing methods for quantifying ecological integrity, shoreline protection, recreational opportunities, fisheries production, and the potential for natural products discovery from reefs. Methods were applied to mapping potential ecosystem services production around St. Croix, U.S. Virgin Islands. Overall, we found that a number of different methods produced similar predictions. Furthermore, areas predicted to be high in ecological integrity also tended to be high in other ecosystem services, including the potential for recreation, natural products discovery, and fisheries production, but this result depended on the method by which ecosystem services supply was calculated. Quantitative methods linking reef condition to ecosystem goods and services can aid in highlighting the social and economic relevance of reefs, and provide essential information to more completely characterize, model, and map the trade-offs inherent in decision options. Published by Elsevier B.V. C1 [Yee, Susan H.; Dittmar, John A.; Oliver, Leah M.] US Environm Protect Agcy, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Breeze, FL 32561 USA. RP Yee, SH (reprint author), US Environm Protect Agcy, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Breeze, FL 32561 USA. EM yee.susan@epa.gcv FU NIMBioS FX We thank P. Principe, W. Fisher, P. Bradley, D. Campbell, A. Casper, J. Bousquin, and D. Santavy for ideas in the early stages of this manuscript, and L. Burke and R. Waite for comments. We thank B. Schaeffer for help processing remote sensing data. We are grateful to NIMBioS for support of the investigative workshop "Modeling sustainability of coral reef ecosystem services under multiple interacting stressors", co-led by S. Yee and J. Ault, from which a need for models linking reef condition to ecosystem services was identified. NR 87 TC 5 Z9 5 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-0416 J9 ECOSYST SERV JI Ecosyst. Serv. PD JUN PY 2014 VL 8 BP 1 EP 15 DI 10.1016/j.ecoser.2014.01.001 PG 15 WC Ecology; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA CU6RR UT WOS:000363661300001 ER PT J AU Beverly, BEJ Lambright, C Furr, J Sampson, H Travlos, G Foster, PM McIntyre, B Wilson, V Gray, LE AF Beverly, Brandiese E. J. Lambright, Christy Furr, Johnathan Sampson, Hunter Travlos, Gregory Foster, Paul M. McIntyre, Barry Wilson, Vickie Gray, L. Earl TI Simvastatin and Dipentyl Phthalate Display Different Modes of Action but Exhibit Dose Additive Effects on Fetal Testicular Testosterone Production in Sprague Dawley Rats SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Beverly, Brandiese E. J.; Lambright, Christy; Furr, Johnathan; Sampson, Hunter; Wilson, Vickie; Gray, L. Earl] US EPA, Washington, DC 20460 USA. [Travlos, Gregory; Foster, Paul M.; McIntyre, Barry] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA OR18-4 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100158 ER PT J AU Sauer, SJ Davis, JB Lyerly, HK Shah, I Williams, KP Devi, GR AF Sauer, Scott Jeffrey Davis, John B. Lyerly, H. Kim Shah, Imran Williams, Kevin P. Devi, Gayathri R. TI Bisphenol a Interacts with Gper, Activates EGFR and ERK Signaling and Antagonizes Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Breast Cancer Cells SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Sauer, Scott Jeffrey; Lyerly, H. Kim; Devi, Gayathri R.] Duke Univ, Med Ctr, Durham, NC USA. [Davis, John B.] Duke Univ, Durham, NC USA. [Shah, Imran] US EPA, Washington, DC 20460 USA. [Williams, Kevin P.] North Carolina Cent Univ, Durham, NC USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SUN-0345 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100232 ER PT J AU Venturutti, L Russo, RIC Yankilevich, P Oakley, RH Huang, THM Schillaci, R Cidlowski, JA Elizalde, PV AF Venturutti, Leandro Cordo Russo, Rosalia Inas Yankilevich, Patricio Oakley, Robert H. Huang, Tim H-M Schillaci, Roxana Cidlowski, John A. Virginia Elizalde, Patricia TI Tumor Suppressor Mir-16 Mediates Trastuzumab Therapeutic Effects in Breast Cancer Via Its Novel Targets, Cyclin J (CCNJ) and Fuse Binding Protein 1 (FUBP1) SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Venturutti, Leandro; Cordo Russo, Rosalia Inas; Schillaci, Roxana; Virginia Elizalde, Patricia] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt, Buenos Aires, DF, Argentina. [Yankilevich, Patricio] IBIOBA CONICET MPSP, Buenos Aires, DF, Argentina. [Oakley, Robert H.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Huang, Tim H-M] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NIEHS NIH, Res Triangle Pk, NC USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SAT-0318 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805108126 ER PT J AU Nestlerode, JA Hansen, VD Teague, A Harwell, MC AF Nestlerode, Janet A. Hansen, Virginia D. Teague, Aarin Harwell, Matthew C. TI Application of a three-tier framework to assess ecological condition of Gulf of Mexico coastal wetlands SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Condition assessment; Gulf of Mexico; Multi-level assessment; Wetland ID NATURAL-RESOURCES; USA; WATERSHEDS; LANDSCAPE; NITROGEN; FLORIDA; SOILS; SCALE; INDEX AB A multi-level coastal wetland assessment strategy was applied to wetlands in the northern Gulf of Mexico (GOM) to evaluate the feasibility of this approach for a broad national scale wetland condition assessment (US Environmental Protection Agency's National Wetlands Condition Assessment). Landscape-scale assessment indicators (tier 1) were developed and applied at the sub-watershed (12-digit hydrologic unit code (HUC)) level within the GOM coastal wetland sample frame with scores calculated using land-use maps and geographic information system. Rapid assessment protocols (tier 2), using a combination of data analysis and field work, evaluated metrics associated with landscape context, hydrology, physical structure, and biological structure. Intensive site monitoring (tier 3) included measures of soil chemistry and composition, water column and pore-water chemistry, and dominant macrophyte community composition and tissue chemistry. Relationships within and among assessment levels were evaluated using multivariate analyses with few significant correlations found. More detailed measures of hydrology, soils, and macrophyte species composition from sites across a known condition gradient, in conjunction with validation of standardized rapid assessment method, may be necessary to fully characterize coastal wetlands across the region. C1 [Nestlerode, Janet A.; Hansen, Virginia D.; Teague, Aarin; Harwell, Matthew C.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Nestlerode, JA (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM nestlerode.janet@epa.gov FU US Environmental Protection Agency FX We would like to thank A. Almario, B. Boshart, G. Craven, K. Cretini, D. Dantin, R. Day, A. Diz, B. Gossman, K. Kaack, T. Heitmuller, M. Kaintz, S. Merino, E. Milbrandt, P. O'Donnell, J. Pahl, S. Piazza, A. Piehler, G. Snedden, G. Steyer, and J. Troutman for field and lab support. We sincerely thank Y. Allen and P. Bourgeois for assistance with survey design, landscape analyses, and persistence in obtaining permission to sample study sites. We thank R. Gibble, G. Serenbetz, and several anonymous reviewers for constructive comments on earlier drafts. For site access, map data, and general guidance, thanks go to the private landowners and public land managers throughout the Gulf region where the probabilistic survey points were located. Sincere appreciation is also given to the Louisiana Department of Natural Resources Coastal Restoration Division, USGS-NWRC Coastal Restoration Field Station (Baton Rouge), Rookery Bay National Estuarine Research Reserve, J. Collins, M. Sutula, and all the participants in the 2006 Gulf of Mexico Coastal Wetlands Survey Design and Indicator Development Workshop for insight and recommendations to the best approaches and available technology to assess the condition of wetlands within the northern Gulf of Mexico coastal region. The information in this document has been funded by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 71 TC 1 Z9 1 U1 4 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD JUN PY 2014 VL 186 IS 6 BP 3477 EP 3493 DI 10.1007/s10661-014-3631-y PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA AG1DZ UT WOS:000335156600012 PM 24473682 ER PT J AU Lebrec, H Molinier, B Boverhof, D Collinge, M Freebern, W Henson, K Mytych, DT Ochs, HD Wange, R Yang, Y Zhou, L Arrington, J Christin-Piche, MS Shenton, J AF Lebrec, Herve Molinier, Brigitte Boverhof, Darrell Collinge, Mark Freebern, Wendy Henson, Kristin Mytych, Daniel T. Ochs, Hans D. Wange, Ronald Yang, Yung Zhou, Lei Arrington, Joshua Christin-Piche, Marie Soleil Shenton, Jacintha TI The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE TDAR; Nonclinical studies; Immunotoxicity ID KEYHOLE-LIMPET HEMOCYANIN; HUMORAL IMMUNE-RESPONSE; IMMUNOTOXICOLOGICAL FUNCTIONAL ASSAY; SEVERE COMBINED IMMUNODEFICIENCY; HAZARD IDENTIFICATION PURPOSES; BONE-MARROW-TRANSPLANTATION; SCHISTOSOMA-MANSONI; IN-VIVO; BACTERIOPHAGE PHI-X-174; STANDARD TOXICOLOGY AB The T-cell-dependent antibody response (TDAR) assay is a measure of immune function that is dependent upon the effectiveness of multiple immune processes, including antigen uptake and presentation, T cell help, B cell activation, and antibody production. It is used for risk and safety assessments, in conjunction with other toxicologic assessments, by the chemical and pharmaceutical industries, and research and regulatory agencies. It is also employed to evaluate investigational drug efficacy in animal pharmacology studies, provide evidence of biological impact in clinical trials, and evaluate immune function in patients with primary or secondary immunodeficiency diseases. Various immunization schemes, analytical methods, approaches to data analysis, and data interpretations are in use. This manuscript summarizes some recommended practices for the conduct and interpretation of the assay in animal studies. (C) 2014 Elsevier Inc. All rights reserved. C1 [Lebrec, Herve] Amgen Inc, Seattle, WA USA. [Molinier, Brigitte] Sanofi Aventis R&D, Montpellier, France. [Boverhof, Darrell] Dow Chem Co USA, Midland, MI 48674 USA. [Collinge, Mark] Pfizer Inc, Groton, CT 06340 USA. [Freebern, Wendy] Bristol Myers Squibb Co, New Brunswick, NJ USA. [Henson, Kristin] Novartis Inst Biomed Res Inc, E Hartford, NJ USA. [Mytych, Daniel T.] Amgen Inc, Thousand Oaks, CA USA. [Ochs, Hans D.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Ochs, Hans D.] Seattle Childrens Res Inst, Seattle, WA USA. [Wange, Ronald] Food & Drug Adm, Washington, DC USA. [Yang, Yung] US Environm Protect Agcy, Off Pesticides Programs, Washington, DC USA. [Arrington, Joshua] Covance Inc, Madison, WI USA. [Christin-Piche, Marie Soleil] Charles River Labs, Montreal, PQ, Canada. [Shenton, Jacintha] MedImmune Ltd, Cambridge, England. RP Lebrec, H (reprint author), Amgen Inc, 1201 Amgen Court West,AW1-J4144, Seattle, WA 98119 USA. EM hlebrec@amgen.com NR 90 TC 1 Z9 1 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD JUN PY 2014 VL 69 IS 1 BP 7 EP 21 DI 10.1016/j.yrtph.2014.02.008 PG 15 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AG0SL UT WOS:000335125800002 PM 24566336 ER PT J AU Aylward, LL Ramasamy, S Hays, SM Schoeny, R Kirman, CR AF Aylward, Lesa L. Ramasamy, Santhini Hays, Sean M. Schoeny, Rita Kirman, Christopher R. TI Evaluation of urinary speciated arsenic in NHANES: Issues in interpretation in the context of potential inorganic arsenic exposure SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Arsenic; Biomonitoring; Exposure assessment; NHANES ID HUMAN RISK-ASSESSMENT; BIOMONITORING EQUIVALENTS; METHYLATION CAPABILITY; SOUTHWESTERN TAIWAN; DRINKING-WATER; US POPULATION; SKIN-CANCER; METABOLITES; SEAFOOD; BANGLADESH AB Urinary dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) are among the commonly used biomarkers for inorganic arsenic (iAs) exposure, but may also arise from seafood consumption and organoarsenical pesticide applications. We examined speciated urinary arsenic data from National Health and Nutrition Examination Survey (NHANES) 2009-2010 cycle to assess potential correlations among urinary DMA, MMA, and the organic arsenic species arsenobetaine. Urinary DMA and MMA were positively associated with urinary arsenobetaine, suggesting direct exposure to these species in seafood or metabolism of organic arsenicals to these species, although the biomonitoring data do not directly identify the sources of exposure. The magnitude of association was much larger for DMA than for MMA. The secondary methylation index (SMI, ratio of urinary DMA to MMA) observed in the NHANES program likewise is much higher in persons with detected arsenobetaine than in those without, again suggesting that direct DMA exposure is co-occurring with exposure to arsenobetaine. Urinary MMA was less correlated with organic arsenic exposures than DMA and, therefore, may be a more reliable biomarker for iAs exposure in the general US population. However, given the associations between both MMA and DMA and organic arsenic species in urine, interpretations of the urinary arsenic concentrations observed in the NHANES in the context of potential arsenic exposure should be made cautiously. (C) 2014 Published by Elsevier Inc. C1 [Aylward, Lesa L.] LLP, Summit Toxicol, Falls Church, VA 22044 USA. [Ramasamy, Santhini] US Environm Protect Agcy, Off Water, Washington, DC USA. [Hays, Sean M.] LLP, Summit Toxicol, Lyons, CO USA. [Schoeny, Rita] US Environm Protect Agcy, Off Res & Dev, US Environm Protect Agcy, Washington, DC USA. [Kirman, Christopher R.] LLP, Summit Toxicol, Orange Village, OH USA. RP Aylward, LL (reprint author), LLP, Summit Toxicol, 6343 Carolyn Dr, Falls Church, VA 22044 USA. EM laylward@summittoxicology.com RI Aylward, Lesa/F-7418-2012 OI Aylward, Lesa/0000-0003-3191-8175 FU American Chemistry Council FX Authors LLA, SMH, and CRK received funding to support preparation of this analysis from the American Chemistry Council. NR 43 TC 14 Z9 14 U1 1 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD JUN PY 2014 VL 69 IS 1 BP 49 EP 54 DI 10.1016/j.yrtph.2014.02.011 PG 6 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AG0SL UT WOS:000335125800005 PM 24582650 ER PT J AU Hubal, EAC de Wet, T Du Toit, L Firestone, MP Ruchirawat, M van Engelen, J Vickers, C AF Hubal, Elaine A. Cohen de Wet, Thea Du Toit, Lilo Firestone, Michael P. Ruchirawat, Mathuros van Engelen, Jacqueline Vickers, Carolyn TI Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: Results of a World Health Organization review SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Review DE Risk assessment; Harmonized early life age groups; Childhood life stages; Windows of exposure; Windows of susceptibility; Cultural and geographic modifying factors; Developmental changes in children; Exposure to environmental contaminants; Exposure factors ID LONGITUDINAL BIRTH COHORT; INTERNATIONAL GROWTH REFERENCE; ASSESSING CHILDRENS EXPOSURE; CRITICAL WINDOWS; NATIONAL CHILDRENS; YOUNG-CHILDREN; PUBLIC-HEALTH; FEEDING PRACTICES; CHILDHOOD; CHEMICALS AB In this paper, we summarize exposure-related issues to consider in determining the most appropriate age ranges and life stages for risk assessment. We then propose a harmonized set of age bins for monitoring and assessing risks from exposures to chemicals for global use. The focus is on preconception through adolescence, though the approach should be applicable to additional life stages. A two-tiered set of early life age groups is recommended. The first tier involves the adoption of guidance similar to the childhood age groups recommended by the U.S. Environmental Protection Agency, whereas the second tier consolidates some of those age groups to reduce the burden of developing age-specific exposure factors for different regions. While there is no single "correct" means of choosing a common set of age groups to use internationally in assessing early life exposure and risk, use of a set of defined age groups is recommended to facilitate comparisons of potential exposures and risks around the globe, the collection of data and analyses of aggregate exposure and cumulative risk. Application of these age groups for robust assessment of exposure and risk for specific populations will require region-specific exposure factors as well as local environmental monitoring data. (C) 2013 World Health Organization. Published by Elsevier Inc. All rights reserved. C1 [Hubal, Elaine A. Cohen] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [de Wet, Thea] Univ Johannesburg, Ctr Anthropol Res, Auckland Pk, South Africa. [de Wet, Thea] Univ Johannesburg, Dept Anthropol & Dev Studies, Auckland Pk, South Africa. [Du Toit, Lilo] Univ Witwatersrand, Fac Hlth Sci, Ctr Rural Hlth, Johannesburg, South Africa. [Firestone, Michael P.] US EPA, Regulatory Support & Sci Policy Div, Off Childrens Hlth Protect, Off Adm, Washington, DC 20460 USA. [Ruchirawat, Mathuros] Chulabhorn Res Inst, Res Off, Bangkok 10210, Thailand. [van Engelen, Jacqueline] Natl Inst Publ Hlth & Environm RIVM, Ctr Sustainabil Environm & Hlth, NL-3720 BA Bilthoven, Netherlands. [Vickers, Carolyn] WHO, Int Programme Chem Safety, CH-1211 Geneva 27, Switzerland. RP Vickers, C (reprint author), WHO, Int Programme Chem Safety, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM Hubal.Elaine@epamail.epa.gov; tdewet@uj.ac.za; Lilo.Dutoit@wits.ac.za; Firestone.michael@epa.gov; mathuros@cri.or.th; jacqueline.van.engelen@rivm.nl; vickersc@who.int NR 103 TC 8 Z9 8 U1 3 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD JUN PY 2014 VL 69 IS 1 BP 113 EP 124 DI 10.1016/j.yrtph.2013.09.008 PG 12 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AG0SL UT WOS:000335125800011 ER PT J AU Levine, CR Yanai, RD Lampman, GG Burns, DA Driscoll, CT Lawrence, GB Lynch, JA Schoch, N AF Levine, Carrie R. Yanai, Ruth D. Lampman, Gregory G. Burns, Douglas A. Driscoll, Charles T. Lawrence, Gregory B. Lynch, Jason A. Schoch, Nina TI "Evaluating the efficiency of environmental monitoring programs" (vol 39, pg 94, 2014) SO ECOLOGICAL INDICATORS LA English DT Correction C1 [Levine, Carrie R.; Yanai, Ruth D.] Univ Calif Berkeley, Coll Environm Sci & Forestry, Dept Forest & Nat Resources Management, Berkeley, CA 94720 USA. [Lampman, Gregory G.] New York State Energy Res & Dev Author, New York, NY 12203 USA. [Burns, Douglas A.; Lawrence, Gregory B.] US Geol Survey, Troy, NY 12180 USA. [Driscoll, Charles T.] Syracuse Univ, Dept Civil & Environm Engn, Syracuse, NY 13244 USA. [Lynch, Jason A.] US EPA, Clean Air Markets Div, Washington, DC 20460 USA. [Lynch, Jason A.] Biodivers Res Inst, Gorham, ME USA. RP Levine, CR (reprint author), Univ Calif Berkeley, Dept Environm Sci Policy & Management, 130 Mulford Hall, Berkeley, CA 94720 USA. EM crlevine@berkeley.edu; rdyanai@syr.edu; ggl@nyserda.ny.gov; daburns@usgs.gov; ctdrisco@syr.edu; glawrenc@usgs.gov; lynch.jason@epamaiLepa.gov; nina.schoch@briloon.org NR 1 TC 0 Z9 0 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD JUN PY 2014 VL 41 BP 215 EP 215 DI 10.1016/j.ecolind.2014.01.032 PG 1 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AF6JU UT WOS:000334822200025 ER PT J AU Bhavaraju, L Shannahan, J William, A McCormick, R McGee, J Kodavanti, U Madden, M AF Bhavaraju, Laya Shannahan, Jonathan William, Aaron McCormick, Robert McGee, John Kodavanti, Urmila Madden, Michael TI Diesel and biodiesel exhaust particle effects on rat alveolar macrophages with in vitro exposure SO CHEMOSPHERE LA English DT Article DE Prostaglandin E-2; Alveolar macrophages; Biodiesel exhaust; Diesel exhaust ID PARTICULATE MATTER; OXIDATIVE STRESS; EMISSION PARTICLES; COX-2 EXPRESSION; ENGINE; INHALATION; TOXICITY; CARBON; FUEL; PM AB Combustion emissions from diesel engines emit particulate matter which deposits within the lungs. Alveolar macrophages (AMs) encounter the particles and attempt to engulf the particles. Emissions particles from diesel combustion engines have been found to contain diverse biologically active components including metals and polyaromatic hydrocarbons which cause adverse health effects. However little is known about AM response to particles from the incorporation of biodiesel. The objective of this study was to examine the toxicity in Wistar Kyoto rat AM of biodiesel blend (B20) and low sulfur petroleum diesel (PDEP) exhaust particles. Particles were independently suspended in media at a range of 1-500 mu g mL(-1). Results indicated B20 and PDEP initiated a dose dependent increase of inflammatory signals from AM after exposure. After 24 h exposure to B20 and PDEP gene expression of cyclooxygenase-2 (COX-2) and macrophage inflammatory protein 2 (MIP-2) increased. B20 exposure resulted in elevated prostaglandin E-2 (PGE(2)) release at lower particle concentrations compared to PDEP. B20 and PDEP demonstrated similar affinity for sequestration of PGE(2) at high concentrations, suggesting detection is not impaired. Our data suggests PGE(2) release from AM is dependent on the chemical composition of the particles. Particle analysis including measurements of metals and ions indicate B20 contains more of select metals than PDEP. Other particle components generally reduced by 20% with 20% incorporation of biodiesel into original diesel. This study shows AM exposure to B20 results in increased production of PGE(2) in vitro relative to diesel. Published by Elsevier Ltd. C1 [Bhavaraju, Laya] Univ N Carolina, Currciculum Toxicol, Chapel Hill, NC USA. [Shannahan, Jonathan] Univ Colorado, Sch Pharm, Denver, CO 80202 USA. [William, Aaron; McCormick, Robert] Natl Renewable Energy Lab, Golden, CO USA. [McGee, John; Kodavanti, Urmila; Madden, Michael] US EPA, NHEERL, EPHD, Res Triangle Pk, NC 27711 USA. RP Madden, M (reprint author), US EPA, Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM madden.michael@epa.gov RI McCormick, Robert/B-7928-2011 FU NIEHS Toxicology Training Grant [T32 ES007126]; UNC-EPA [CR833237] FX Supported in part by NIEHS Toxicology Training Grant, T32 ES007126 and UNC-EPA Training Agreement CR833237. NR 35 TC 5 Z9 5 U1 3 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JUN PY 2014 VL 104 BP 126 EP 133 DI 10.1016/j.chemosphere.2013.10.080 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE6EX UT WOS:000334084500019 PM 24268344 ER PT J AU Stockwell, JD Yule, DL Hrabik, TR Sierszen, ME Isaac, EJ AF Stockwell, Jason D. Yule, Daniel L. Hrabik, Thomas R. Sierszen, Michael E. Isaac, Edmund J. TI Habitat coupling in a large lake system: delivery of an energy subsidy by an offshore planktivore to the nearshore zone of Lake Superior SO FRESHWATER BIOLOGY LA English DT Article DE foraging; whitefish; cisco; winter ecology; eggs ID WHITEFISH COREGONUS-CLUPEAFORMIS; DIEL VERTICAL MIGRATION; LAURENTIAN GREAT-LAKES; FISH COMMUNITY; STABLE-ISOTOPES; BIOENERGETICS MODEL; ECOSYSTEM ECOLOGY; CARBON ISOTOPES; MYSIS-RELICTA; FLATHEAD LAKE AB We hypothesised that the autumn spawning migration of Lake Superior cisco (Coregonus artedi) provides a resource subsidy, in the form of energy-rich cisco eggs, from the offshore pelagic to the nearshore benthic community over winter, when alternate prey production is likely to be low. We tested this hypothesis using fish and macroinvertebrate surveys, fish population demographics, diet and stable isotope analyses, and bioenergetics modelling. The benthic, congeneric lake whitefish (C.clupeaformis) was a clear beneficiary of cisco spawning. Cisco eggs represented 16% of lake whitefish annual consumption in terms of biomass, but 34% of energy (because of their high energy density: >10kJgwetmass(-1)). Stable isotope analyses were consistent with these results and suggest that other nearshore fish species may also rely on cisco eggs. The lipid content of lake whitefish liver almost doubled from 26 to 49% between November and March, while that of muscle increased from 14 to 26% over the same period, suggesting lake whitefish were building, rather than depleting, lipid reserves during winter. In the other Laurentian Great Lakes, where cisco populations remain very low and rehabilitation efforts are underway, the offshore-to-nearshore ecological link apparent in Lake Superior has been replaced by non-native planktivorous species. These non-native species spawn in spring have smaller eggs and shorter incubation periods. The rehabilitation of cisco in these systems should reinstate the onshore subsidy as it has in Lake Superior. C1 [Stockwell, Jason D.] Univ Vermont, Rubenstein Ecosyst Sci Lab, Burlington, VT 05401 USA. [Yule, Daniel L.] USGS Great Lakes Sci Ctr, Lake Super Biol Stn, Ashland, WI USA. [Hrabik, Thomas R.] Univ Minnesota, Dept Biol, Duluth, MN 55812 USA. [Sierszen, Michael E.] US EPA, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA. [Sierszen, Michael E.; Isaac, Edmund J.] Grand Portage Band Lake Super Chippewa, Grand Portage, MN USA. RP Stockwell, JD (reprint author), Univ Vermont, Rubenstein Ecosyst Sci Lab, 3 Coll St, Burlington, VT 05401 USA. EM jason.stockwell@uvm.edu NR 85 TC 12 Z9 12 U1 2 U2 53 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0046-5070 EI 1365-2427 J9 FRESHWATER BIOL JI Freshw. Biol. PD JUN PY 2014 VL 59 IS 6 BP 1197 EP 1212 DI 10.1111/fwb.12340 PG 16 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA AE4PK UT WOS:000333964700008 ER PT J AU Huang, XL El Badawy, A Arambewela, M Ford, R Barlaz, M Tolaymat, T AF Huang, Xiao-Lan El Badawy, Amro Arambewela, Mahendranath Ford, Robert Barlaz, Morton Tolaymat, Thabet TI Characterization of salt cake from secondary aluminum production SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Aluminum; Mineral phase; Leachability; Salt cake; Secondary aluminum production (SAP); Toxicity characteristic leaching procedure (TCLP) ID MANAGEMENT; DROSS; LANDFILL; WASTE AB Salt cake is a major waste component generated from the recycling of secondary aluminum processing (SAP) waste. Worldwide, the aluminum industry produces nearly 5 million tons of waste annually and the end-of-life management of these wastes is becoming a challenge in the U.S. and elsewhere. In this study, the mineral phases, metal content and metal leachability of 39 SAP waste salt cake samples collected from 10 different facilities across the U.S. were determined. The results showed that aluminum (Al), aluminum oxide, aluminum nitride and its oxides, spinel and elpasolite are the dominant aluminum mineral phases in salt cake. The average total Al content was 14% (w/w). The overall percentage of the total leachable Al in salt cake was 0.6% with approximately 80% of the samples leaching at a level less than 1% of the total aluminum content. The extracted trace metal concentrations in deionized water were relatively low (mu g L-1 level). The toxicity characteristic leaching procedure (TCLP) was employed to further evaluate leachability and the results indicated that the leached concentrations of toxic metals from salt cake were much lower than the EPA toxicity limit set by USEPA. Published by Elsevier B.V. C1 [Huang, Xiao-Lan; El Badawy, Amro; Arambewela, Mahendranath] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Ford, Robert; Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45224 USA. [Barlaz, Morton] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. RP Tolaymat, T (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45224 USA. EM tolaymat.thabet@epamail.epa.gov RI Huang (黄), Xiao-Lan (晓澜)/E-9159-2010 OI Huang (黄), Xiao-Lan (晓澜)/0000-0002-3330-4858 FU USEPA's Office of Research and Development National Risk Management Research Laboratory FX This research was funded by the USEPA's Office of Research and Development National Risk Management Research Laboratory. This paper has not been subjected to the Agency's internal review, therefore, the opinions expressed in this paper are those of the author(s) and do not, necessarily, reflect the official positions and policies of the USEPA. Any mention of products or trade names does not constitute recommendation for use by the USEPA. NR 54 TC 5 Z9 5 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAY 30 PY 2014 VL 273 BP 192 EP 199 DI 10.1016/j.jhazmat.2014.02.035 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AI4FP UT WOS:000336821400024 PM 24747373 ER PT J AU Vinson, MR Angradi, TR AF Vinson, Mark R. Angradi, Ted R. TI Muskie Lunacy: Does the Lunar Cycle Influence Angler Catch of Muskellunge (Esox masquinongy)? SO PLOS ONE LA English DT Article ID MOON PHASE; FISH; PERIODICITY; BEHAVIOR; SALMON; RATES; LAKE; POPULATIONS; REGRESSION; MIGRATION AB We analyzed angling catch records for 341,959 muskellunge (Esox masquinongy) from North America to test for a cyclic lunar influence on the catch. Using periodic regression, we showed that the number caught was strongly related to the 29-day lunar cycle, and the effect was consistent across most fisheries. More muskellunge were caught around the full and new moon than at other times. At night, more muskellunge were caught around the full moon than the new moon. The predicted maximum relative effect was approximate to 5% overall. Anglers fishing exclusively on the peak lunar day would, on average, catch 5% more muskellunge than anglers fishing on random days. On some lakes and at night, the maximum relative effect was higher. We obtained angler effort data for Wisconsin, Mille Lacs (MN), and Lake Vermilion (MN). For Lake Vermilion there was a significant effect of the lunar cycle on angler effort. We could therefore not conclude that the lunar effect on catch was due to an effect on fish behavior alone. Several factors affected the amount of variation explained by the lunar cycle. The lunar effect was stronger for larger muskellunge (> 102 cm) than for smaller fish, stronger in midsummer than in June or October, and stronger for fish caught at high latitudes (>48 degrees N) than for fish caught further south. There was no difference in the lunar effect between expert and novice muskellunge anglers. We argue that this variation is evidence that the effect of the lunar cycle on catch is mediated by biological factors and is not due solely to angler effort and reflects lunar synchronization in feeding. This effect has been attributed to variation among moon phases in lunar illumination, but our results do not support that hypothesis for angler-caught muskellunge. C1 [Vinson, Mark R.] US Geol Survey, Great Lakes Sci Ctr, Lake Super Biol Stn, Ashland, WI 54806 USA. [Angradi, Ted R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA. RP Vinson, MR (reprint author), US Geol Survey, Great Lakes Sci Ctr, Lake Super Biol Stn, Ashland, WI 54806 USA. EM mvinson@usgs.gov FU U.S. Geological Survey; U.S. Environmental Protection Agency FX This work was supported by the U.S. Geological Survey and the U.S. Environmental Protection Agency. The views expressed in this paper are the authors' and do not necessarily reflect U.S. Geological Survey or U.S. Environmental Protection Agency policy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 2 Z9 2 U1 4 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 28 PY 2014 VL 9 IS 5 AR e98046 DI 10.1371/journal.pone.0098046 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4TS UT WOS:000336858300023 PM 24871329 ER PT J AU Butcher, JB Johnson, TE Nover, D Sarkar, S AF Butcher, Jonathan B. Johnson, Thomas E. Nover, Daniel Sarkar, Saumya TI Incorporating the effects of increased atmospheric CO2 in watershed model projections of climate change impacts SO JOURNAL OF HYDROLOGY LA English DT Article DE Climate change; Evapotranspiration; CO2; HSPF; SWAT; Stomatal conductance ID CHANGE SENSITIVITY ASSESSMENT; MISSISSIPPI RIVER-BASIN; LAND-COVER DATABASE; STOMATAL CONDUCTANCE; CARBON-DIOXIDE; UNITED-STATES; EPIC MODEL; HYDROLOGY; NITROGEN; QUALITY AB Assessment Tool (SWAT) are frequently used to project the responses of watershed processes to climate change, but do not always represent the effects of changes in atmospheric CO2 concentrations on plant growth. Projected increases in atmospheric CO2 concentrations may decrease the need for plants to maintain stomatal conductance to achieve sufficient CO2 inputs, thereby also reducing the transpiration of water with potentially important effects on watershed water balance. We first compare the SWAT model, which provides an option to explicitly represent the effects of increased CO2 to implementations of the SWAT model without this option and to the HSPF model, which does not include a representation of CO2 response. Both models are capable of representing watershed responses to current climatic conditions. For analysis of response to future conditions, the SWAT model with integrated plant growth response to increased CO2 predicts an increase in streamflows relative to models without the CO2 response, consistent with previous research. We then develop methods to incorporate CO2 impacts on evapotranspiration into a physically based modeling framework, such as HSPF, that does not explicitly model plant growth. With these modifications, HSPF also projects an increase in future runoff relative to simulations without accounting for the CO2 effect, although smaller than the increase predicted by SWAT with identical assumptions for stomatal conductance. The results suggest that, while the effect of reduced plant transpiration due to increased atmospheric CO2 is important, it is likely to be overestimated by both the current formulation of the SWAT model and modified versions that reduce the stomatal conductance response for woody plants. A general approach to modifying watershed models to simulate response of plant transpiration to increased atmospheric CO2 under climate change is also proposed. (C) 2014 The Authors. Published by Elsevier B.V. C1 [Butcher, Jonathan B.; Sarkar, Saumya] Tetra Tech Inc, Res Triangle Pk, NC 27709 USA. [Johnson, Thomas E.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Nover, Daniel] US Agcy Int Dev, West African Reg Off, Accra, Ghana. RP Butcher, JB (reprint author), Tetra Tech Inc, POB 14409, Res Triangle Pk, NC 27709 USA. EM jon.butcher@tetratech.com; Johnson.Thomas@epa.gov; dmnover@gmail.com; sam.sarkar@tetratech.com FU National Science Foundation; U.S. Environmental Protection Agency, Office of Research and Development FX We thank Debjani Deb, Pushpa Tuppad, and Raghavan Srinivasan of Texas A82M University for developing the SWAT models of the ACF, Minnesota River, and Willamette River watersheds. Jeremy Wyss of Tetra Tech developed the ACF HSPF model, while Brian Bicknell and John Imhoff of AQUA TERRA were responsible for developing the Salt/San Pedro/Verde, Susquehanna, and Willamette HSPF models. Mustafa Faizullabhoy of Tetra Tech processed all the climate scenario data. The writers also thank Seth McGinnis of the National Center for Atmospheric Research (NCAR) for processing the NARCCAP output into change statistics for use in the watershed modeling, as well as the NARCCAP and BCSD project teams. NCAR is supported by the National Science Foundation. The writers acknowledge the modeling groups, the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and the WCRP's Working Group on Coupled Modeling (WGCM) for their roles in making available the WCRP CMIP3 multi-model data set. Support of this data set is provided by the Office of Science, U.S. Department of Energy. Funding for this work was provided by the U.S. Environmental Protection Agency, Office of Research and Development. The views expressed in this paper represent those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 60 TC 11 Z9 12 U1 3 U2 35 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD MAY 26 PY 2014 VL 513 BP 322 EP 334 DI 10.1016/j.jhydrol.2014.03.073 PG 13 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AI9NI UT WOS:000337258900030 ER PT J AU Messer, LC Jagai, JS Rappazzo, KM Lobdell, DT AF Messer, Lynne C. Jagai, Jyotsna S. Rappazzo, Kristen M. Lobdell, Danelle T. TI Construction of an environmental quality index for public health research SO ENVIRONMENTAL HEALTH LA English DT Article DE Environmental quality; Air quality; Water quality; Land quality; Built environment; Sociodemographic; Rural-urban status ID AIR-POLLUTION; NEIGHBORHOOD DEPRIVATION; RURAL RESIDENCE; EXPOSURE; URBAN; BIRTH; TEXAS; VULNERABILITY; CALIFORNIA; MORTALITY AB Background: A more comprehensive estimate of environmental quality would improve our understanding of the relationship between environmental conditions and human health. An environmental quality index (EQI) for all counties in the U.S. was developed. Methods: The EQI was developed in four parts: domain identification; data source acquisition; variable construction; and data reduction. Five environmental domains (air, water, land, built and sociodemographic) were recognized. Within each domain, data sources were identified; each was temporally (years 2000-2005) and geographically (county) restricted. Variables were constructed for each domain and assessed for missingness, collinearity, and normality. Domain-specific data reduction was accomplished using principal components analysis (PCA), resulting in domain-specific indices. Domain-specific indices were then combined into an overall EQI using PCA. In each PCA procedure, the first principal component was retained. Both domain-specific indices and overall EQI were stratified by four rural-urban continuum codes (RUCC). Higher values for each index were set to correspond to areas with poorer environmental quality. Results: Concentrations of included variables differed across rural-urban strata, as did within-domain variable loadings, and domain index loadings for the EQI. In general, higher values of the air and sociodemographic indices were found in the more metropolitan areas and the most thinly populated areas have the lowest values of each of the domain indices. The less-urbanized counties (RUCC 3) demonstrated the greatest heterogeneity and range of EQI scores (-4.76, 3.57) while the thinly populated strata (RUCC 4) contained counties with the most positive scores (EQI score ranges from -5.86, 2.52). Conclusion: The EQI holds promise for improving our characterization of the overall environment for public health. The EQI describes the non-residential ambient county-level conditions to which residents are exposed and domain-specific EQI loadings indicate which of the environmental domains account for the largest portion of the variability in the EQI environment. The EQI was constructed for all counties in the United States, incorporating a variety of data to provide a broad picture of environmental conditions. We undertook a reproducible approach that primarily utilized publically-available data sources. C1 [Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community Hlth, Portland, OR 97207 USA. [Jagai, Jyotsna S.; Lobdell, Danelle T.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27599 USA. [Jagai, Jyotsna S.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA. [Rappazzo, Kristen M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Rappazzo, Kristen M.] US EPA, Oak Ridge Inst Sci & Educ, Natl Ctr Environm Assessment, Oak Ridge, TN USA. RP Lobdell, DT (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27599 USA. EM lobdell.danelle@epa.gov FU Innovate!, Inc.; EPA; University of North Carolina at Chapel Hill [CR83323601]; Office of Research and Development (ORD); U.S. Environmental Protection Agency (EPA); [WCF DP26H0001]; [EP09D000003] FX The Office of Research and Development (ORD), U.S. Environmental Protection Agency (EPA), partially funded the research with Innovate!, Inc. and L. C. Messer (Contracts WCF DP26H0001 and EP09D000003) and under EPA Cooperative Agreement with the University of North Carolina at Chapel Hill (CR83323601) and an appointment to the Research Participation Program for the U. S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 31 TC 5 Z9 5 U1 3 U2 17 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD MAY 22 PY 2014 VL 13 AR 39 DI 10.1186/1476-069X-13-39 PG 22 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AJ0CS UT WOS:000337317400001 PM 24886426 ER PT J AU Wagner, JG Kamal, AS Morishita, M Dvonch, JT Harkema, JR Rohr, AC AF Wagner, James G. Kamal, Ali S. Morishita, Masako Dvonch, J. Timothy Harkema, Jack R. Rohr, Annette C. TI PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions SO PARTICLE AND FIBRE TOXICOLOGY LA English DT Article DE Air pollution; Blood pressure; Elemental carbon; Heart rate; Inhalation; Organic carbon; PM2.5; Rat ID FINE PARTICULATE MATTER; HEART-RATE-VARIABILITY; SPONTANEOUSLY HYPERTENSIVE-RATS; AIR-POLLUTION; BLOOD-PRESSURE; SOURCE APPORTIONMENT; CHEMICAL-COMPOSITION; DIESEL EXHAUST; BLACK CARBON; FRACTIONS AB Background: We tested the hypothesis that cardiovascular responses to PM2.5 exposure will be enhanced in hypertensive rats and linked to specific carbonaceous pollutants in an urban industrial setting. Methods: Spontaneously hypertensive rats were exposed by inhalation to concentrated PM2.5 in an industrial area of Dearborn, Michigan, for four consecutive summer days. Blood pressure (BP), heart rate (HR) and HR variability (HRV) metrics (SDNN, RMSSD) were assessed by radiotelemetry and compared to 1 h-and 8 h-averaged fluctuations in PM2.5 composition, with a focus on elemental and organic carbon (EC and OC, respectively), and temperature-resolved subfractions (EC1-EC5, PC (pyrolized carbon), and OC1-OC4), as well as other major and minor PM components. Results: Mean HR and BP were increased, while HRV was decreased over 4 days of exposure. Using 1 h averages, EC (1 mu g/m(3) increase) was associated with increased HR of 11-32 bpm (4-11% increase), 1.2-1.5 ms (22-27%) decreases in SDNN, 3-14 mmHg (1.5-8%) increases in systolic BP, and 5-12 mmHg (4-9%) increases in diastolic BP. By comparison, associations with OC were negligible. Using 8 h averages, EC subfractions were linked with increased heart rate (EC1: 13 bpm; EC2, EC3, PC: < 5 bpm) and SDNN (EC1> > EC2 > EC3, EC4, PC), but with decreased RMSSD (EC2, EC5 > EC3, EC4). Minimal effects were associated with OC and OC1. Associations between carbon subfractions and BP were negligible. Associations with non-carbonaceous components and trace elements were generally non-significant or of negligible effect size. Conclusions: These findings are the first to describe associations between acute cardiovascular responses and thermally resolved carbon subfractions. We report that cardiovascular responses to PM2.5 carbonaceous materials appear to be driven by EC and its EC1 fraction. C1 [Wagner, James G.; Harkema, Jack R.] Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA. [Wagner, James G.; Harkema, Jack R.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA. [Kamal, Ali S.] US EPA, Human Exposure & Atmospher Sci Div, NERL, Res Triangle Pk, NC 27711 USA. [Morishita, Masako; Dvonch, J. Timothy] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Rohr, Annette C.] Elect Power Res Inst, Palo Alto, CA USA. [Wagner, James G.] Michigan State Univ, E Lansing, MI 48824 USA. RP Wagner, JG (reprint author), Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA. EM wagnerja@msu.edu RI Dvonch, Joseph/K-3632-2013 FU Electric Power Research Institute; Environmental Protection Agency [R83479701]; STAR Clean Air Research Centers program FX This project is supported by the Electric Power Research Institute and the Environmental Protection Agency, R83479701, STAR Clean Air Research Centers program. We thank the following valued colleagues at Michigan State University: Lori Bramble, Ryan Lewandowski, and Dr. Daven Jackson-Humbles, and at the University of Michigan: James Barres, and Dr. Lynn Gratz. NR 45 TC 3 Z9 4 U1 3 U2 26 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-8977 J9 PART FIBRE TOXICOL JI Part. Fibre Toxicol. PD MAY 22 PY 2014 VL 11 AR 25 DI 10.1186/1743-8977-11-25 PG 10 WC Toxicology SC Toxicology GA AI6LH UT WOS:000336985500001 PM 24885999 ER PT J AU Carey, JC Fulweiler, RW AF Carey, Joanna C. Fulweiler, Robinson W. TI Silica uptake by Spartina-evidence of multiple modes of accumulation from salt marshes around the world SO FRONTIERS IN PLANT SCIENCE LA English DT Article DE Spartina; salt marsh; silica; accumulation; grasses; wetland; ecosystem service ID BIOGENIC SILICA; PHENOTYPIC PLASTICITY; BIOGEOCHEMICAL CYCLE; ACCRETION RATES; SCHELDE ESTUARY; TIDAL WETLANDS; HIGHER-PLANTS; ECOSYSTEM; TRANSPORT; NITROGEN AB Silicon (Si) plays a critical role in plant functional ecology, protecting plants from multiple environmental stressors. While all terrestrial plants contain some Si, wetland grasses are frequently found to have the highest concentrations, although the mechanisms driving Si accumulation in wetland grasses remain in large part uncertain. For example, active Si accumulation is often assumed to be responsible for elevated Si concentrations found in wetland grasses. However, life stage and differences in Si availability in the surrounding environment also appear to be important variables controlling the Si concentrations of wetland grasses. Here we used original data from five North American salt marshes, as well as all known published literature values, to examine the primary drivers of Si accumulation in Spartina, a genus of prolific salt marsh grasses found worldwide. We found evidence of multiple modes of Si accumulation in Spartina, with passive accumulation observed in non-degraded marshes where Spartina was native, while rejective accumulation was found in regions where Spartina was invasive. Evidence of active accumulation was found in only one marsh where Spartina was native, but was also subjected to nutrient over-enrichment. We developed a conceptual model which hypothesizes that the mode of Si uptake by Spartina is dependent on local environmental factors and genetic origin, supporting the idea that plant species should be placed along a spectrum of Si accumulation. We hypothesize that Spartina exhibits previously unrecognized phenotypic plasticity with regard to Si accumulation, allowing these plants to respond to changes in marsh condition. These results provide new insight regarding how salt marsh ecosystems regulate Si exchange at the land-sea interface. C1 [Carey, Joanna C.; Fulweiler, Robinson W.] Boston Univ, Dept Earth & Environm, Boston, MA 02215 USA. [Fulweiler, Robinson W.] Boston Univ, Dept Biol, Boston, MA 02215 USA. RP Carey, JC (reprint author), US EPA, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM joanna.carey@gmail.com FU Estuarine Reserves Division, Office of Ocean and Coastal Resource Management, National Ocean Service, National Oceanographic and Atmospheric Association Graduate Research Assistantship; L. L. Bean Acadia Research Fellowship; Department of Earth and Environment at Boston University; Sloan Foundation through the Sloan Fellowship FX We are grateful for field assistance by Jules Opton-Himmel, Kenneth Raposa, Daisy Durant, Amanda Vieillard, Margaret Notopoulos, and Sarah Sargent. In addition, we thank the following people for laboratory assistance: Amanda Vieillard, Elise Greenberg, Ashley Banks, Megan Ware, Suzann Duan, and especially Courtney Zambory. We thank Adrien Finzi for generously allowing us to use his lab and equipment to grind vegetation samples. This research was conducted under an award from the Estuarine Reserves Division, Office of Ocean and Coastal Resource Management, National Ocean Service, National Oceanographic and Atmospheric Association Graduate Research Assistantship and an L. L. Bean Acadia Research Fellowship to Joanna C. Carey. We thank the Department of Earth and Environment at Boston University for partial funding support of Joanna C. Carey. We also thank the Sloan Foundation who provided support for this work to Robinson W. Fulweiler through the Sloan Fellowship. NR 58 TC 6 Z9 6 U1 2 U2 31 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-462X J9 FRONT PLANT SCI JI Front. Plant Sci. PD MAY 20 PY 2014 VL 5 AR 186 DI 10.3389/fpls.2014.00186 PG 11 WC Plant Sciences SC Plant Sciences GA AI5MR UT WOS:000336912100001 PM 24904599 ER PT J AU Gomez-Alvarez, V Schrantz, KA Pressman, JG Wahman, DG AF Gomez-Alvarez, Vicente Schrantz, Karen A. Pressman, Jonathan G. Wahman, David G. TI Biofilm Community Dynamics in Bench-Scale Annular Reactors Simulating Arrestment of Chloraminated Drinking Water Nitrification SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID AMMONIA-OXIDIZING ARCHAEA; BACTERIAL COMMUNITIES; DISTRIBUTION-SYSTEM; MICROBIAL DIVERSITY; AREA RELATIONSHIP; REGIME SHIFTS; RESISTANCE; ACID; DISINFECTION; RESILIENCE AB Annular reactors (ARs) were used to study biofilm community succession and provide ecological insight during nitrification arrestment through simultaneously increasing monochloramine (NH2Cl) and chlorine to nitrogen mass ratios, resulting in four operational periods (I-IV). Analysis of 16S rRNA-encoding gene sequence reads (454-pyrosequencing) examined viable and total biofilm communities and found total samples were representative of the underlying viable community. Bacterial community structure showed dynamic changes corresponding with AR operational parameters. Period I (complete nitrification and no NH2Cl residual) was dominated by Bradyrhizobium (total cumulative distribution: 38%), while environmental Legionella-like phylotypes peaked (19%) during Period II (complete nitrification and minimal NH2CI residual). Nitrospira moscoviensis (nitrite-oxidizing bacteria) was detected in early periods (2%) but decreased to <0.02% in later periods, corresponding to nitrite accumulation. Methylobacterium (19%) and members of Nitrosomonadaceae (42%) dominated Period III (complete ammonia and partial nitrite oxidation and low NH2CI residual). An increase in Afipia (haloacetic acid-degrading bacteria) relative abundance (<2% to 42%) occurred during Period TV (minimal nitrification and moderate to high NH2CI residual). Microbial community and operational data provided no evidence of taxa-time relationship, but rapid community transitions indicated that the system had experienced ecological regime shifts to alternative stable states. C1 [Gomez-Alvarez, Vicente; Schrantz, Karen A.; Pressman, Jonathan G.; Wahman, David G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Wahman, DG (reprint author), US EPA, Off Res & Dev, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM wahman.david@epa.gov OI Wahman, David/0000-0002-0167-8468 FU USEPA through the Office of Research and Development FX We thank Pegasus Technical Services, Inc. for research assistance. The USEPA through the Office of Research and Development funded and managed this research. It has been subjected to the Agency's peer and administrative review and has been approved for external publication. The opinions expressed in this paper are those of the authors and do not necessarily reflect the official positions and policies of the USEPA. Any mention of product or trade names does not constitute recommendation for use by the USEPA. NR 67 TC 7 Z9 7 U1 11 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 20 PY 2014 VL 48 IS 10 BP 5448 EP 5457 DI 10.1021/es5005208 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AH8VB UT WOS:000336415200014 PM 24754322 ER PT J AU Washington, JW Naile, JE Jenkins, TM Lynch, DG AF Washington, John W. Naile, Jonathan E. Jenkins, Thomas M. Lynch, David G. TI Characterizing Fluorotelomer and Polyfluoroalkyl Substances in New and Aged Fluorotelomer-Based Polymers for Degradation Studies with GC/MS and LC/MS/MS SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SLUDGE-APPLIED SOILS; PERFLUORINATED COMPOUNDS; MASS-SPECTROMETRY; CHROMATOGRAPHY; OPTIMIZATION; PERSISTENCE; EXTRACTION; ALCOHOLS; ALABAMA; DECATUR AB Fluorotelomer-based polymers (FTPs), the dominant product of the fluorotelomer industry, are antistaining and antiwetting agents that permeate the products and surfaces of modern society. However, the degree to which these materials expose humans and the environment to fluorotelomer and perfluorinated compounds, including recalcitrant and toxic compounds such as perfluorooctanoic acid (PFOA), is ill-defined. The design intent of FTPs, to minimize interaction with other substances, including solvents, heretofore has stymied efforts to develop robust methods to characterize the content of monomers and associated compounds of new commercial FTPs, as well as commercial FTPs that have been aged in environmental media for degradation testing. Here we show that FTPs can be exhausted of these compounds and quantitated by (i) drying the FTP on a suitable substrate at elevated temperature to achieve low, constant monomer concentrations; (ii) serial extraction with MTBE for fluorotelomer-monomer analysis by GC/MS in PCI mode; followed by (iii) serial extraction with 90/10 ACN/H2O for polyfluorocompound analysis by LC/MS/MS in negative ESI mode. This approach yields exhaustive, internally consistent accounting of monomers and associated compounds for FTPs, either alone or in a soil matrix (representing an environmental medium), for both new and simulated-aged FTPs to allow degradation testing, and for fluorinated compounds at least as long as C12. C1 [Washington, John W.; Naile, Jonathan E.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Jenkins, Thomas M.] US EPA, Senior Environm Employment Program, Athens, GA 30605 USA. [Lynch, David G.] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA. RP Washington, JW (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. EM Washington.john@epa.gov FU USEPA Office of Research and Development; Office of Pollution Prevention and Toxics FX This research was funded by the USEPA Office of Research and Development and Office of Pollution Prevention and Toxics. We thank Tim Collette, Eric Weber, Jack Jones, Greg Fritz, and Laurence Libelo, all of the EPA, and the editor and manuscript reviewers for insightful discussions. This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. NR 26 TC 11 Z9 11 U1 9 U2 53 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 20 PY 2014 VL 48 IS 10 BP 5762 EP 5769 DI 10.1021/es500373b PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AH8VB UT WOS:000336415200050 PM 24749955 ER PT J AU Herwehe, JA Alapaty, K Spero, TL Nolte, CG AF Herwehe, Jerold A. Alapaty, Kiran Spero, Tanya L. Nolte, Christopher G. TI Increasing the credibility of regional climate simulations by introducing subgrid-scale cloud-radiation interactions SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID CONVECTIVE PARAMETERIZATION; UNCERTAINTY QUANTIFICATION; WEATHER RESEARCH; MODELING SYSTEM; LAND-SURFACE; WRF; REANALYSIS; UPDATE; SCHEME; COVER AB The radiation schemes in the Weather Research and Forecasting (WRF) model have previously not accounted for the presence of subgrid-scale cumulus clouds, thereby resulting in unattenuated shortwave radiation, which can lead to overly energetic convection and overpredicted surface precipitation. This deficiency can become problematic when applying WRF as a regional climate model (RCM). Therefore, modifications were made to the WRF model to allow the Kain-Fritsch (KF) convective parameterization to provide subgrid-scale cloud fraction and condensate feedback to the rapid radiative transfer model-global (RRTMG) shortwave and longwave radiation schemes. The effects of these changes are analyzed via 3 year simulations using the standard and modified versions of WRF, comparing the modeled results with the North American Regional Reanalysis (NARR) and Climate Forecast System Reanalysis data, as well as with available data from the Surface Radiation Network and Clouds and Earth's Radiant Energy System. During the summer period, including subgrid cloudiness estimated by KF in the RRTMG reduces the surface shortwave radiation, leading to less buoyant energy, which is reflected in a smaller diabatic convective available potential energy, thereby alleviating the overly energetic convection. Overall, these changes have reduced the overprediction of monthly, regionally averaged precipitation during summer for this RCM application, e. g., by as much as 49 mm for the southeastern U. S., to within 0.7% of the NARR value of 221 mm. These code modifications have been incorporated as an option available in the latest version of WRF (v3.6). C1 [Herwehe, Jerold A.; Alapaty, Kiran; Spero, Tanya L.; Nolte, Christopher G.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Herwehe, JA (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM herwehe.jerry@epa.gov RI Nolte, Christopher/H-4345-2012; OI Nolte, Christopher/0000-0001-5224-9965; Spero, Tanya/0000-0002-1600-0422 NR 43 TC 15 Z9 15 U1 0 U2 14 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAY 19 PY 2014 VL 119 IS 9 BP 5317 EP 5330 DI 10.1002/2014JD021504 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AK3QS UT WOS:000338340400019 ER PT J AU Pinto, JP Dibb, J Lee, BH Rappengluck, B Wood, EC Levy, M Zhang, RY Lefer, B Ren, XR Stutz, J Tsai, C Ackermann, L Golovko, J Herndon, SC Oakes, M Meng, QY Munger, JW Zahniser, M Zheng, J AF Pinto, J. P. Dibb, J. Lee, B. H. Rappenglueck, B. Wood, E. C. Levy, M. Zhang, R. -Y. Lefer, B. Ren, X. -R. Stutz, J. Tsai, C. Ackermann, L. Golovko, J. Herndon, S. C. Oakes, M. Meng, Q. -Y. Munger, J. W. Zahniser, M. Zheng, J. TI Intercomparison of field measurements of nitrous acid (HONO) during the SHARP campaign SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID TEXAS AIR-QUALITY; NITRIC-ACID; CHEMISTRY; HOUSTON; OZONE; INSTRUMENT; ABSORPTION; ATMOSPHERE; SULFATE; IMPACT AB Because of the importance of HONO as a radical reservoir, consistent and accurate measurements of its concentration are needed. As part of SHARP (Study of Houston Atmospheric Radical Precursors), time series of HONO were obtained by six different measurement techniques on the roof of the Moody Tower at the University of Houston. Techniques used were long path differential optical absorption spectroscopy (DOAS), stripping coil-visible absorption photometry (SC-AP), long path absorption photometry (LOPAP (R)), mist chamber/ion chromatography (MC-IC), quantum cascade-tunable infrared laser differential absorption spectroscopy (QC-TILDAS), and ion drift-chemical ionization mass spectrometry (ID-CIMS). Various combinations of techniques were in operation from 15 April through 31 May 2009. All instruments recorded a similar diurnal pattern of HONO concentrations with higher median and mean values during the night than during the day. Highest values were observed in the final 2 weeks of the campaign. Inlets for the MC-IC, SC-AP, and QC-TILDAS were collocated and agreed most closely with each other based on several measures. Largest differences between pairs of measurements were evident during the day for concentrations similar to 100 parts per trillion (ppt). Above similar to 200 ppt, concentrations from the SC-AP, MC-IC, and QC-TILDAS converged to within about 20%, with slightly larger discrepancies when DOAS was considered. During the first 2 weeks, HONO measured by ID-CIMS agreed with these techniques, but ID-CIMS reported higher values during the afternoon and evening of the final 4 weeks, possibly from interference from unknown sources. A number of factors, including building related sources, likely affected measured concentrations. C1 [Pinto, J. P.] US EPA, Natl Ctr Environm Assessment, Durham, NC 27711 USA. [Dibb, J.] Univ New Hampshire, Inst Study Earth Oceans & Space, Durham, NH 03824 USA. [Lee, B. H.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Rappenglueck, B.; Lefer, B.; Ackermann, L.; Golovko, J.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX USA. [Wood, E. C.] Univ Massachusetts, Dept Environm Hlth Sci, Amherst, MA 01003 USA. [Wood, E. C.; Herndon, S. C.; Zahniser, M.] Aerodyne Res Inc, Billerica, MA USA. [Levy, M.; Zhang, R. -Y.; Zheng, J.] Texas A&M Univ, Dept Atmospher Sci, College Stn, TX USA. [Ren, X. -R.] Univ Miami, Rosentiel Sch Marine & Atmospher Sci, Coral Gables, FL 33124 USA. [Stutz, J.; Tsai, C.] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA. [Oakes, M.] Oak Ridge Inst Sci Educ, Oak Ridge, TN USA. [Meng, Q. -Y.] Univ Med & Dent New Jersey, Dept Environm & Occupat Hlth, Piscataway, NJ 08854 USA. [Munger, J. W.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Pinto, JP (reprint author), US EPA, Natl Ctr Environm Assessment, Durham, NC 27711 USA. EM pinto.joseph@epa.gov RI Lee, Ben/G-7007-2014; Stutz, Jochen/K-7159-2014; Levy, Misti/G-8660-2014; Zhang, Renyi/A-2942-2011; Zheng, Jun/E-6772-2010; Munger, J/H-4502-2013; Ren, Xinrong/E-7838-2015 OI Lee, Ben/0000-0002-5057-2168; Levy, Misti/0000-0002-4832-7753; Munger, J/0000-0002-1042-8452; Ren, Xinrong/0000-0001-9974-1666 FU State of Texas under the Texas Emissions Reduction Plan (TERP) through the Texas Environmental Research Consortium (TERC); Office of Research and Development, U.S. EPA; Robert A. Welch Foundation [A-1417]; National Science Foundation [AGS-0914619]; National Natural Science Foundation of China [41275142] FX We would like to acknowledge the various participants in the SHARP campaign who made data available and Stephen McDow and David Svendsgaard for useful discussions. Funding for SHARP was provided by the State of Texas under the Texas Emissions Reduction Plan (TERP) through the Texas Environmental Research Consortium (TERC). The information in this document has been subjected to review by the National Center for Environmental Assessment, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. In addition to data presented in the manuscript and SI, additional information can be obtained from the individual investigators cross referenced in the author list and Table 1. M.O. was supported by an appointment to the Research Participation Program at the Office of Research and Development, U.S. EPA, administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. DOE and EPA. R.Z. acknowledges additional support from the Robert A. Welch Foundation (A-1417). X. R. acknowledges partial support from the National Science Foundation (AGS-0914619). J.Z. acknowledges support from the National Natural Science Foundation of China (41275142). NR 43 TC 10 Z9 10 U1 7 U2 53 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAY 19 PY 2014 VL 119 IS 9 BP 5583 EP 5601 DI 10.1002/2013JD020287 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AK3QS UT WOS:000338340400036 ER PT J AU Kahnt, A Iinuma, Y Blockhuys, F Mutzel, A Vermeylen, R Kleindienst, TE Jaoui, M Offenberg, JH Lewandowski, M Boge, O Herrmann, H Maenhaut, W Claeys, M AF Kahnt, Ariane Iinuma, Yoshiteru Blockhuys, Frank Mutzel, Anke Vermeylen, Reinhilde Kleindienst, Tadeusz E. Jaoui, Mohammed Offenberg, John H. Lewandowski, Michael Boege, Olaf Herrmann, Hartmut Maenhaut, Willy Claeys, Magda TI 2-Hydroxyterpenylic Acid: An Oxygenated Marker Compound for alpha-Pinene Secondary Organic Aerosol in Ambient Fine Aerosol SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID IONIZATION MASS-SPECTROMETRY; MOLECULAR COMPOSITION; CHEMICAL-CHARACTERIZATION; ATMOSPHERIC AEROSOLS; BETA-PINENE; OXIDATION; FOREST; PHOTOOXIDATION; ENVIRONMENTS; OZONOLYSIS AB An oxygenated MW 188 compound is commonly observed in substantial abundance in atmospheric aerosol samples and was proposed in previous studies as an a-pinene-related marker compound that is associated with aging processes. Owing to difficulties in producing this compound in sufficient amounts in laboratory studies and the occurrence of isobaric isomers, a complete assignment for individual MW 188 compounds could not be achieved in these studies. Results from a comprehensive mass spectrometric analysis are presented here to corroborate the proposed structure of the most abundant MW 188 compound as a 2-hydroxyterpenylic acid diastereoisomer with 2R,3R configuration. The application of collision-induced dissociation with liquid chromatography/electrospray ionization-ion trap mass spectrometry in both negative and positive ion modes, as well as chemical derivatization to methyl ester derivatives and analysis by the latter technique and gas chromatography/electron ionization mass spectrometry, enabled a comprehensive characterization of MW 188 isomers, including a detailed study of the fragmentation behavior using both mass spectrometric techniques. Furthermore, a MW 188 positional isomer, 4-hydroxyterpenylic acid, was tentatively identified, which also is of atmospheric relevance as it could be detected in ambient fine aerosol. Quantum chemical calculations were performed to support the diastereoisomeric assignment of the 2-hydroxyterpenylic acid isomers. Results from a time-resolved a-pinene photooxidation experiment show that the 2-hydroxyterpenylic acid 2R,3R diastereoisomer has a time profile distinctly different from that of 3-methyl-1,2,3-butanetricarboxylic acid, a marker for oxygenated (aged) secondary organic aerosol. This study presents a comprehensive chemical data set for a more complete structural characterization of hydroxyterpenylic acids in ambient fine aerosol, which sets the foundation to better understand the atmospheric fate of a-pinene in future studies. C1 [Kahnt, Ariane; Vermeylen, Reinhilde; Maenhaut, Willy; Claeys, Magda] Univ Antwerp, Dept Pharmaceut Sci, BE-2610 Antwerp, Belgium. [Blockhuys, Frank] Univ Antwerp, Dept Chem, BE-2610 Antwerp, Belgium. [Iinuma, Yoshiteru; Mutzel, Anke; Boege, Olaf; Herrmann, Hartmut] Leibniz Inst Tropospharenforsch TROPOS, D-04318 Leipzig, Germany. [Kleindienst, Tadeusz E.; Offenberg, John H.; Lewandowski, Michael] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Jaoui, Mohammed] Alion Sci & Technol, Res Triangle Pk, NC 27711 USA. [Maenhaut, Willy] Univ Ghent, Dept Analyt Chem, BE-9000 Ghent, Belgium. RP Claeys, M (reprint author), Univ Antwerp, Dept Pharmaceut Sci, Campus Drie Eiken, BE-2610 Antwerp, Belgium. EM magda.claeys@uantwerpen.be RI Maenhaut, Willy/M-3091-2013; Offenberg, John/C-3787-2009; Herrmann, Hartmut/C-2486-2009 OI Maenhaut, Willy/0000-0002-4715-4627; Offenberg, John/0000-0002-0213-4024; Herrmann, Hartmut/0000-0001-7044-2101 FU Belgian Federal Science Policy Office through the network project "Biogenic Influence on Oxidants and Secondary Organic Aerosol: theoretical, laboratory and modeling investigations (BIOSOA)"; Research Foundation-Flanders (FWO); European Commission [228335]; Office of Research and Development [EP-D-10-070] FX Research at the University of Antwerp and TROPOS was supported by the Belgian Federal Science Policy Office through the network project "Biogenic Influence on Oxidants and Secondary Organic Aerosol: theoretical, laboratory and modeling investigations (BIOSOA)". Research at the University of Antwerp was also supported by the Research Foundation-Flanders (FWO), whereas research at TROPOS was also supported by the European Commission through the EURO-CHAMP-2 project (228335). We thank Christian Van Alsenoy from the Department of Chemistry of the University of Antwerp for supporting the quantum theoretical calculations and fruitful discussions. The U.S. Environmental Protection Agency was supported through its Office of Research and Development partially funded and collaborated in the research described here under contract EP-D-10-070 to Alion Science and Technology. The article has been reviewed by EPA personnel under EPA scientific and technical peer review procedures and approved for joint publication based on its scientific merit, technical accuracy, or contribution to advancing public understanding of environmental protection. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use. NR 30 TC 8 Z9 8 U1 2 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 6 PY 2014 VL 48 IS 9 BP 4901 EP 4908 DI 10.1021/es500377d PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AG9DY UT WOS:000335720100033 PM 24697354 ER PT J AU Ranatunga, T Tong, STY Sun, Y Yang, YJ AF Ranatunga, Thushara Tong, Susanna T. Y. Sun, Yu Yang, Y. Jeffrey TI A total water management analysis of the Las Vegas Wash watershed, Nevada SO PHYSICAL GEOGRAPHY LA English DT Article DE Las Vegas; population change; total water management; climate change; watershed hydrologic modeling; land-use/land-cover change ID COLORADO RIVER-BASIN; CLIMATE-CHANGE; LAND-USE; RESOURCES; MODEL; HSPF; HYDROLOGY; DYNAMICS; IMPACTS; CONSERVATION AB Climate change, land-use change, and population growth are fundamental factors affecting future hydrologic conditions in streams, especially in arid regions with scarce water resources. Located in the arid southwest within the Las Vegas Wash watershed, Las Vegas is one of the fastest growing metropolitan areas of the country. In the past 30 years, because of climate and land-use changes, it has experienced a decrease in clean water supply but an increase in water demand. To alleviate some of these problems, large amounts of water have been pumped into the city from different sources, such as Lake Mead, and the urban wastewater is treated and returned back to the reservoir for water augmentation. However, in the face of continual global climate change and urbanization in the watershed, long-term planning for sustainable water management is critical. This research was designed to provide a comprehensive analysis incorporating hydrologic modeling, population projection, land-use change modeling, and water management policies to examine the total water balance and management options in this arid and rapidly urbanizing watershed under various scenarios of climate regime, population growth, land-use change, and total water management programs for the year 2050. C1 [Ranatunga, Thushara; Tong, Susanna T. Y.; Sun, Yu] Univ Cincinnati, Dept Geog, Cincinnati, OH 45220 USA. [Yang, Y. Jeffrey] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Tong, STY (reprint author), Univ Cincinnati, Dept Geog, 401 Braunstein Hall,ML 131, Cincinnati, OH 45220 USA. EM susanna.tong@uc.edu FU US Environmental Protection Agency [EP-C-11-006] FX This work was partially supported by the US Environmental Protection Agency [grant number EP-C-11-006]. The authors are grateful to the agency for the financial support. The manuscript has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 54 TC 3 Z9 3 U1 4 U2 68 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0272-3646 EI 1930-0557 J9 PHYS GEOGR JI Phys. Geogr. PD MAY 4 PY 2014 VL 35 IS 3 BP 220 EP 244 DI 10.1080/02723646.2014.908763 PG 25 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Physical Geography; Geology; Meteorology & Atmospheric Sciences GA AH1EN UT WOS:000335862700003 ER PT J AU Sonntag, DB Baldauf, RW Yanca, CA Fulper, CR AF Sonntag, Darrell B. Baldauf, Richard W. Yanca, Catherine A. Fulper, Carl R. TI Particulate matter speciation profiles for light-duty gasoline vehicles in the United States SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID POWERED MOTOR-VEHICLES; CHEMICAL-COMPOSITION; ORGANIC-COMPOUNDS; LUBRICATING OIL; TRACE-ELEMENTS; EMISSIONS; DIESEL; METALS AB Representative profiles for particulate matter particles less than or equal to 2.5 mu m (PM2.5) are developed from the Kansas City Light-Duty Vehicle Emissions Study for use in the U.S. Environmental Protection Agency (EPA) vehicle emission model, the Motor Vehicle Emission Simulator (MOVES), and for inclusion in the EPA SPECIATE database for speciation profiles. The profiles are compatible with the inputs of current photochemical air quality models, including the Community Multiscale Air Quality Aerosol Module Version 6 (AE6). The composition of light-duty gasoline PM2.5 emissions differs significantly between cold start and hot stabilized running emissions, and between older and newer vehicles, reflecting both impacts of aging/deterioration and changes in vehicle technology. Fleet-average PM2.5 profiles are estimated for cold start and hot stabilized running emission processes. Fleet-average profiles are calculated to include emissions from deteriorated high-emitting vehicles that are expected to continue to contribute disproportionately to the fleet-wide PM2.5 emissions into the future. The profiles are calculated using a weighted average of the PM2.5 composition according to the contribution of PM2.5 emissions from each class of vehicles in the on-road gasoline fleet in the Kansas City Metropolitan Statistical Area. The paper introduces methods to exclude insignificant measurements, correct for organic carbon positive artifact, and control for contamination from the testing infrastructure in developing speciation profiles. The uncertainty of the PM2.5 species fraction in each profile is quantified using sampling survey analysis methods. The primary use of the profiles is to develop PM2.5 emissions inventories for the United States, but the profiles may also be used in source apportionment, atmospheric modeling, and exposure assessment, and as a basis for light-duty gasoline emission profiles for countries with limited data. Implications: PM2.5 speciation profiles were developed from a large sample of light-duty gasoline vehicles tested in the Kansas City area. Separate PM2.5 profiles represent cold start and hot stabilized running emission processes to distinguish important differences in chemical composition. Statistical analysis was used to construct profiles that represent PM2.5 emissions from the U.S. vehicle fleet based on vehicles tested from the 2005 calendar year Kansas City metropolitan area. The profiles have been incorporated into the EPA MOVES emissions model, as well as the EPA SPECIATE database, to improve emission inventories and provide the PM2.5 chemical characterization needed by CMAQv5.0 for atmospheric chemistry modeling. C1 [Sonntag, Darrell B.; Yanca, Catherine A.; Fulper, Carl R.] US EPA, Natl Vehicle & Fuel Emiss Lab, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA. [Baldauf, Richard W.] US EPA, Natl Vehicle & Fuel Emiss Lab, Off Transportat & Air Qual, Res Triangle Pk, NC 27711 USA. [Baldauf, Richard W.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Sonntag, DB (reprint author), US EPA, Natl Vehicle & Fuel Emiss Lab, Off Transportat & Air Qual, 2000 Traverwood Rd, Ann Arbor, MI 48105 USA. EM sonntag.darrell@epa.gov FU American Association for the Advancement of Science (AAAS) fellowship - EPA [X3-83459201]; Oak Ridge Institute for Science and Education (ORISE) program - EPA Office of Transportation and Air Quality FX Funding for PM speciation profile development work reported in this paper was provided through the American Association for the Advancement of Science (AAAS) fellowship under Cooperative Agreement X3-83459201 awarded by the EPA to the AAAS, and through the Oak Ridge Institute for Science and Education (ORISE) program funded by the EPA Office of Transportation and Air Quality. NR 51 TC 0 Z9 0 U1 2 U2 45 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD MAY 4 PY 2014 VL 64 IS 5 BP 529 EP 545 DI 10.1080/10962247.2013.870096 PG 17 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AF7PL UT WOS:000334906900004 PM 24941701 ER PT J AU Evans, AM Rice, GE Wright, JM Teuschler, LK AF Evans, Amanda M. Rice, Glenn E. Wright, J. Michael Teuschler, Linda K. TI Exploratory Cumulative Risk Assessment (CRA) Approaches Using Secondary Data SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE cumulative risk assessment; joint exposures; secondary data analysis; hazard index; non-chemical stressors; chemical mixtures ID SENSORINEURAL HEARING-LOSS; DISEASE PREVALENCE; PERSONAL EXPOSURE; NOISE EXPOSURE; OUTDOOR; TOLUENE; INDOOR; HEALTH; US; OTOTOXICITY AB Cumulative risk assessments (CRAs) include the examination of risks posed by multiple stressors and include population-specific vulnerabilities and susceptibilities. In this case study, we assess potential hearing impairment hazard due to joint exposure from noise and volatile organic compounds (VOCs) in order to examine the strengths and limitations of using secondary data on exposure and health effects for a CRA. Block group-level noise categories were estimated using modeled street-level data. A quantile regression model of sociodemographic and personal predictors from the 1999-2000U.S. National Health and Nutrition Examination Survey VOC dataset was used along with block group-level sociodemographic and personal variables to estimate VOC exposures. Hazard indices (HIs) for potential hearing impairment due to joint noise and VOC exposures were calculated. County-averaged HIs for hearing impairment ranged from 0.8 (10th total VOCs percentile and 45-60dB) to 1.7 (90th total VOCs percentile and 71-75dB). Limitations of the exposure and health effects data included issues combining heterogeneous data and a lack of established threshold levels for combined low-level exposures; yet, this case study illustrates that screening-level CRAs, including non-chemical stressors, can be accomplished with publicly available data and existing methods. C1 [Evans, Amanda M.] Assoc Sch Publ Hlth, Washington, DC USA. [Evans, Amanda M.; Rice, Glenn E.; Wright, J. Michael; Teuschler, Linda K.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Cincinnati, OH 45268 USA. RP Evans, AM (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 26 W Martin Luther King Dr MS-A110, Cincinnati, OH 45268 USA. EM evans.amandam@epa.gov NR 58 TC 1 Z9 1 U1 3 U2 39 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD MAY 4 PY 2014 VL 20 IS 3 BP 704 EP 723 DI 10.1080/10807039.2013.764771 PG 20 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 294CT UT WOS:000330020700009 ER PT J AU Keith, DJ Schaeffer, BA Lunetta, RS Gould, RW Rocha, K Cobb, DJ AF Keith, Darryl J. Schaeffer, Blake A. Lunetta, Ross S. Gould, Richard W., Jr. Rocha, Kenneth Cobb, Donald J. TI Remote sensing of selected water-quality indicators with the hyperspectral imager for the coastal ocean (HICO) sensor SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article ID DISSOLVED ORGANIC-MATTER; CHLOROPHYLL-A CONCENTRATION; TURBID PRODUCTIVE WATERS; GULF-OF-MEXICO; TAMPA-BAY; SEMIANALYTICAL MODEL; LEAVING RADIANCE; COLOR ALGORITHMS; CHESAPEAKE BAY; CLYDE SEA AB The Hyperspectral Imager for the Coastal Ocean (HICO) offers the coastal environmental monitoring community an unprecedented opportunity to observe changes in coastal and estuarine water quality across a range of spatial scales not feasible with traditional field-based monitoring or existing ocean colour satellites. HICO, an Office of Naval Research-sponsored programme, is the first space-based maritime hyperspectral imaging instrument designed specifically for the coastal ocean. HICO has been operating since September 2009 from the Japanese Experiment Module - Exposed Facility on the International Space Station (ISS). The high pixel resolution (approximately 95m at nadir) and hyperspectral imaging capability offer a unique opportunity for characterizing a wide range of water colour constituents that could be used to assess environmental condition. In this study, we transform atmospherically corrected ISS/HICO hyperspectral imagery and derive environmental response variables routinely used for evaluating the environmental condition of coastal ecosystem resources. Using atmospherically corrected HICO imagery and a comprehensive field validation programme, three regionally specific algorithms were developed to estimate basic water-quality properties traditionally measured by monitoring agencies. Results indicated that a three-band chlorophyll a algorithm performed best (R-2=0.62) when compared with in situ measurement data collected 2-4hours of HICO acquisitions. Coloured dissolved organic matter (CDOM) (R-2=0.93) and turbidity (R-2=0.67) were also highly correlated. The distributions of these water-quality indicators were mapped for four estuaries along the northwest coast of Florida from April 2010 to May 2012. However, before the HICO sensor can be transitioned from proof-of-concept to operational status and its data applied to benefit decisions made by coastal managers, problems with vicarious calibration of the sensor need to be resolved and standardized protocols are required for atmospheric correction. Ideally, the sensor should be placed on a polar orbiting platform for greater spatial and temporal coverage as well as for image synchronization with field validation efforts. C1 [Keith, Darryl J.; Rocha, Kenneth; Cobb, Donald J.] US EPA, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Schaeffer, Blake A.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Lunetta, Ross S.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Gould, Richard W., Jr.] Naval Res Lab, Bioopt Phys Proc & Remote Sensing Sect, Stennis Space Ctr, MS 39529 USA. RP Keith, DJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM keith.darryl@epa.gov FU US Environmental Protection Agency Office of Research and Development (ORD) under the Pathfinder Innovation Program; Safe and Sustainable Waters Research Program FX This work was funded by the US Environmental Protection Agency Office of Research and Development (ORD) under the Pathfinder Innovation Program and supported by the Safe and Sustainable Waters Research Program. NR 74 TC 12 Z9 13 U1 3 U2 38 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0143-1161 EI 1366-5901 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD MAY 3 PY 2014 VL 35 IS 9 BP 2927 EP 2962 DI 10.1080/01431161.2014.894663 PG 36 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA AF7OU UT WOS:000334905200001 ER PT J AU Timsit, YE Negishi, M AF Timsit, Yoav E. Negishi, Masahiko TI Coordinated Regulation of Nuclear Receptor CAR by CCRP/DNAJC7, HSP70 and the Ubiquitin-Proteasome System SO PLOS ONE LA English DT Article ID CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR; HEAT-SHOCK PROTEINS; HEPG2 CELLS; MOUSE-LIVER; ANDROSTANE RECEPTOR; SYNERGISTIC ACTIVATION; MOLECULAR CHAPERONES; PRIMARY HEPATOCYTES; GENE-TRANSCRIPTION; ESTROGEN-RECEPTOR AB The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids. Currently, it is known that in its inactive state, CAR is retained in the cytoplasm in a protein complex with HSP90 and the tetratricopeptide repeat protein cytosoplasmic CAR retention protein (CCRP). Upon activation by phenobarbital (PB) or the PB-like inducer 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene (TCPOBOP), CAR translocates into the nucleus. We have identified two new components to the cytoplasmic regulation of CAR: ubiquitin-dependent degradation of CCRP and protein-protein interaction with HSP70. Treatment with the proteasome inhibitor MG132 (5 mu M) causes CAR to accumulate in the cytoplasm of transfected HepG2 cells. In the presence of MG132, TCPOBOP increases CCRP ubiquitination in HepG2 cells co-expressing CAR, while CAR ubiquitination was not detected. MG132 treatment of HepG2 also attenuated of TCPOBOP-induced CAR transcriptional activation on reporter constructs which contain CAR-binding DNA elements derived from the human CYP2B6 gene. The elevation of cytoplasmic CAR protein with MG132 correlated with an increase of HSP70, and to a lesser extent HSP60. Both CCRP and CAR were found to interact with endogenous HSP70 in HepG2 cells by immunoprecipitation analysis. Induction of HSP70 levels by heat shock also increased cytoplasmic CAR levels, similar to the effect of MG132. Lastly, heat shock attenuated TCPOBOP-induced CAR transcriptional activation, also similar to the effect of MG132. Collectively, these data suggest that ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers. C1 [Timsit, Yoav E.; Negishi, Masahiko] Natl Inst Environm Hlth Sci, Pharmacogenet Sect, Lab Reprod & Dev Toxicol, NIH, Res Triangle Pk, NC 27709 USA. RP Negishi, M (reprint author), Natl Inst Environm Hlth Sci, Pharmacogenet Sect, Lab Reprod & Dev Toxicol, NIH, Res Triangle Pk, NC 27709 USA. EM negishi@niehs.nih.gov FU NIH [Z01ES1005-01] FX NIH Intramural Reseach program:: Z01ES1005-01. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 56 TC 5 Z9 5 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 2 PY 2014 VL 9 IS 5 AR e96092 DI 10.1371/journal.pone.0096092 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI1ZS UT WOS:000336655700056 PM 24789201 ER PT J AU Bellinger, BJ Van Mooy, BAS Cotner, JB Fredricks, HF Benitez-Nelson, CR Thompson, J Cotter, A Knuth, ML Godwin, CM AF Bellinger, Brent J. Van Mooy, Benjamin A. S. Cotner, James B. Fredricks, Helen F. Benitez-Nelson, Claudia R. Thompson, Jo Cotter, Anne Knuth, Michael L. Godwin, Casey M. TI Physiological modifications of seston in response to physicochemical gradients within Lake Superior SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID INTACT POLAR DIACYLGLYCEROLIPIDS; DEEP CHLOROPHYLL MAXIMUM; C-N-P; SULFOQUINOVOSYL DIACYLGLYCEROL; RHODOBACTER-SPHAEROIDES; PHYTOPLANKTON GROWTH; PHOSPHATE LIMITATION; NUTRIENT-LIMITATION; NITRATE UPTAKE; PHOSPHORUS AB In September 2011, we investigated the distribution and composition of dissolved and particulate phosphorus (P) pools throughout Lake Superior, a large P-limited freshwater ecosystem. Average seston particulate P (PP) concentrations in the deep chlorophyll maximum (DCM; 85 +/- 28 nmol L-1) were significantly greater than in the epilimnion (63 +/- 22 nmol L-1). In contrast, average particulate organic carbon (POC) : PP (mol : mol) ratios showed the opposite pattern (DCM = 303 : 1 vs. epilimnion = 455 : 1). Mean seston nucleic acid-P concentrations were invariant between the epilimnetic (23 +/- 18 nmol L-1) and DCM (26 +/- 18 nmol L-1) layers, but significantly greater concentrations of intact polar membrane-derived phospholipids were found in the DCM (6 +/- 2 nmol L-1) relative to the epilimnion (4 +/- 2 nmol L-1). Phospholipids were a minor proportion of PP (7-14%) and total membrane lipids (< 30%). Rather, our results suggest that microbial flora of Lake Superior substituted non-phosphorus lipids for phospholipids. In the nitrogen (N)-rich waters, N-based betaine lipids dominated (39-42%) the lipid pool, and concentrations were significantly greater in the P-poor epilimnetic seston. Sulfolipids were also abundant and significantly greater in the epilimnion (7 +/- 2 nmol L-1) than in the DCM (4 +/- 2 nmol L-1), despite low sulfate concentrations relative to marine environments. Our results demonstrate for the first time the importance of plankton producing non-phosphorus lipids for phospholipids as a strategy for reducing cellular P inventories in lacustrine regimes. C1 [Bellinger, Brent J.; Thompson, Jo; Cotter, Anne; Knuth, Michael L.] US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA. [Van Mooy, Benjamin A. S.; Fredricks, Helen F.] Woods Hole Oceanog Inst, Dept Marine Chem & Geochem, Woods Hole, MA 02543 USA. [Cotner, James B.; Godwin, Casey M.] Univ Minnesota, Dept Ecol, Evolut & Behav, St Paul, MN 55108 USA. [Benitez-Nelson, Claudia R.] Univ S Carolina, Marine Sci Program & Dept Earth & Ocean Sci, Columbia, SC USA. RP Bellinger, BJ (reprint author), US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA. EM bjbellin@mtu.edu RI Godwin, Casey/E-6892-2014; OI Godwin, Casey/0000-0002-4454-7521; Benitez-Nelson, Claudia/0000-0002-1004-5048 FU WHOI Coastal Ocean Institute; U.S. National Science Foundation [OCE-1031143] FX We thank the Environmental Protection Agency (EPA) Great Lakes National Program Office for time on the R/V Lake Guardian, and we are appreciative for the assistance of the crew, Jack Kelly, and the EPA-Mid-Continent Ecology Division for the opportunity to collaborate with the Cooperative Science and Monitoring Initiative project. We are grateful to the lab staff at the Woods Hole Oceanographic Institution (WHOI) and the University of Minnesota for their help in analyzing samples. Funding for intact polar lipid training and analysis at WHOI was provided by the WHOI Coastal Ocean Institute. B. A. S. Van Mooy and H. F. Fredricks were supported by a grant from the U.S. National Science Foundation (OCE-1031143). We give thanks to Ann St. Amand at PhycoTech, who carried out the taxonomic analyses, and Tom Kincaid at EPA-Western Ecology Division for generating the area-weighted lake-wide estimates from the data. Thoughtful reviews were provided by Jack Kelly, Elizabeth Minor, and two anonymous referees. NR 58 TC 2 Z9 2 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0024-3590 EI 1939-5590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD MAY PY 2014 VL 59 IS 3 BP 1011 EP 1026 DI 10.4319/lo.2014.59.3.1011 PG 16 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA AM5MQ UT WOS:000339904300029 ER PT J AU Soares, J Caspersen, CJ McMurray, RG McCurdy, TR AF Soares, Jesus Caspersen, Carl J. McMurray, Robert G. McCurdy, Thomas R. TI Resting Metabolic Rate and Percent Body Fat in Healthy Adult Men and Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Soares, Jesus; Caspersen, Carl J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [McMurray, Robert G.] Univ N Carolina, Chapel Hill, NC USA. [McCurdy, Thomas R.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1823 BP 490 EP 491 PG 2 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115903184 ER PT J AU Knudsen, TB AF Knudsen, T. B. TI Teratology v2.0: Building a path forward SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Knudsen, T. B.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS 01 BP 76 EP 76 DI 10.1016/j.ntt.2014.04.004 PG 1 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800011 ER PT J AU Bushnell, PJ Tatum-Gibbs, R Mckee, JM Evansky, PA Higuchi, M MLin, MT Oshiro, WM Judson, R Hester, S Reif, D Morozova, T Mackay, TFC Boyes, WK AF Bushnell, P. J. Tatum-Gibbs, R. McKee, J. M. Evansky, P. A. Higuchi, M. MLin, M. T. Oshiro, W. M. Judson, R. Hester, S. Reif, D. Morozova, T. Mackay, T. F. C. Boyes, W. K. TI ToxiFly: Can fruit flies be used to identify toxicity pathways for airborne chemicals? SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Bushnell, P. J.; McKee, J. M.; Evansky, P. A.; Higuchi, M.; Oshiro, W. M.; Boyes, W. K.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA. [Tatum-Gibbs, R.; MLin, M. T.; Hester, S.] Oak Ridge Inst Sci Educ, Oak Ridge, TN USA. [Judson, R.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. [Reif, D.] N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA. [Morozova, T.; Mackay, T. F. C.] N Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS 42 BP 89 EP 89 DI 10.1016/j.ntt.2014.04.045 PG 1 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800052 ER PT J AU Segal, D AF Segal, D. TI The HPA axis and the interaction of nonchemical stressors with neurodevelopmental toxicants SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Segal, D.] Environm Protect Agcy, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS P06 BP 91 EP 92 DI 10.1016/j.ntt.2014.04.051 PG 2 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800058 ER PT J AU Gilbert, M Sanchez-Huerta, K Wood, C AF Gilbert, M. Sanchez-Huerta, K. Wood, C. TI Developmental hypothyroidism reduces the expression of activity-dependent plasticity genes in dentate gyrus of the adult following long-term potentiation SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Gilbert, M.; Wood, C.] US EPA, Res Triangle Pk, NC 27711 USA. [Sanchez-Huerta, K.] IPN, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS P15 BP 94 EP 95 DI 10.1016/j.ntt.2014.04.060 PG 2 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800067 ER PT J AU Moser, G McDaniel, KL Phillips, PM Hedge, JM AF Moser, G. McDaniel, K. L. Phillips, P. M. Hedge, J. M. TI Neurobehavioral and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCPP) SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Moser, G.; McDaniel, K. L.; Phillips, P. M.; Hedge, J. M.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 2 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS P21 BP 97 EP 97 DI 10.1016/j.ntt.2014.04.066 PG 1 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800073 ER PT J AU Boyes, WK Degn, LL Martin, SA Lyke, DF Hamm, CW Herr, DW AF Boyes, William K. Degn, Laura L. Martin, Sheppard A. Lyke, Danielle F. Hamm, Charles W. Herr, David W. TI Neurophysiological assessment of auditory, peripheral nerve, somatosensory, and visual system functions after developmental exposure to ethanol vapors SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Ethanol vapor; Developmental neurotoxicity; Nerve conduction velocity; Sensory evoked potentials; Electroretinogram ID FETAL ALCOHOL SYNDROME; SENSORY EVOKED-POTENTIALS; BRAIN-STEM; PRENATAL EXPOSURE; RAT; NUMBERS; CORTEX; ADULT; TOXICITY; BEHAVIOR AB Ethanol-blended gasoline entered the market in response to demand for domestic renewable energy sources, and may result in increased inhalation of ethanol vapors in combination with other volatile gasoline constituents. It is important to understand potential risks of inhalation of ethanol vapors by themselves, and also as a baseline for evaluating the risks of ethanol combined with a complex mixture of hydrocarbon vapors. Because sensory dysfunction has been reported after developmental exposure to ethanol, we evaluated the effects of developmental exposure to ethanol vapors on neurophysiological measures of sensory function as a component of a larger project evaluating developmental ethanol toxicity. Pregnant Long-Evans rats were exposed to target concentrations 0, 5000, 10,000, or 21,000 ppm ethanol vapors for 6.5 h/day over GD9-GD20. Sensory evaluations of male offspring began between PND106 and PND128. Peripheral nerve function (compound action potentials, nerve conduction velocity (NCV)), somatosensory (cortical and cerebellar evoked potentials), auditory (brainstem auditory evoked responses), and visual evoked responses were assessed. Visual function assessment included pattern elicited visual evoked potentials (VEPs), VEP contrast sensitivity, and electroretinograms recorded from dark-adapted (scotopic), light-adapted (photopic) flashes, and UV flicker and green flicker. No consistent concentration-related changes were observed for any of the physiological measures. The results show that gestational exposure to ethanol vapor did not result in detectable changes in peripheral nerve, somatosensory, auditory, or visual function when the offspring were assessed as adults. Published by Elsevier Inc. C1 [Boyes, William K.; Degn, Laura L.; Martin, Sheppard A.; Lyke, Danielle F.; Hamm, Charles W.; Herr, David W.] US EPA, Toxic Assessment Div, Neurotoxicol Branch, NHEERL,ORD, Res Triangle Pk, NC 27711 USA. RP Boyes, WK (reprint author), US EPA, NHEERL TAD NB, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Boyes.william@epa.gov; Degn.laura@epa.gov; Martin.Sheppard@epa.gov; Lyke.danielle@epa.gov; Hamm.charlesw@epa.gov; Herr.david@epa.gov NR 43 TC 8 Z9 8 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 BP 1 EP 10 DI 10.1016/j.ntt.2014.02.006 PG 10 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800001 PM 24607749 ER PT J AU Etterson, MA Greenberg, R Hollenhorst, T AF Etterson, Matthew A. Greenberg, Russell Hollenhorst, Tom TI Landscape and regional context differentially affect nest parasitism and nest predation for Wood Thrush in central Virginia, USA SO CONDOR LA English DT Article DE MCestimate; competing risks; edge effects; Wood Thrush; Hylocichla mustelina; nest predation; nest parasitism ID EFFECTIVE MESH SIZE; REPRODUCTIVE SUCCESS; FOREST FRAGMENTATION; MIGRATORY BIRDS; SONGBIRDS; EDGE; MULTISCALE; SELECTION; EXPOSURE; FAILURE AB Many empirical studies have shown that forest-breeding songbirds, and Neotropical migrants in particular, suffer greater rates of nest predation and nest parasitism in smaller forest patches and in fragmented landscapes. To compare the performance of different metrics of spatial habitat configuration resulting from deforestation, we studied nest predation and nest parasitism rates at 200 Wood Thrush (Hylocichla mustelina) nests in eight forest fragments ranging from 82 to 9,171 ha in central Virginia, USA. We analyzed nest parasitism rates using logistic regression and we analyzed daily nest predation rates under a multistate competing risks design. For both analyses we compared the performance of 16 covariates, 11 of which related to the spatial configuration of habitat (e.g., patch size, distance to edge, percent core forest in proximity to nest) and 5 of which were unrelated to habitat (e.g., year, serial date, nest height). Distance to agriculture gained the greatest support in analyses of nest predation and suggested that elevated predation rates are manifest primarily within 50 m of edges; at 5, 10, and 20 m, respectively, the estimated predation rates were 87%, 76%, and 68%. In contrast, biogeographic region received the greatest support in analyses of nest parasitism, which also showed increasing rates of Brown-headed Cowbird (Molothrus ater) parasitism with percent agricultural land and road density within 500 m of a nest. Among regions, the greatest difference seemed to be a virtual absence of nest parasitism along the Blue Ridge in the absence of disturbance (agriculture or road incursion) whereas the other two biogeographic regions showed 20-50% rates of nest parasitism as background rates. Interactive models between spatial configuration metrics and region gained little support from nest predation analyses, but considerable support from the nest parasitism analyses, suggesting regional context plays a more important role in nest parasitism than in nest predation at these central Virginia sites. C1 [Etterson, Matthew A.; Hollenhorst, Tom] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Greenberg, Russell] Smithsonian Inst, Natl Zool Pk, Smithsonian Migratory Bird Ctr, Washington, DC 20008 USA. RP Etterson, MA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA. EM etterson.matthew@epa.gov FU Smithsonian Migratory Bird Center FX Funding for field work was provided by the Smithsonian Migratory Bird Center. Traynor Biasiolli, Francesca May, and Wanda San Jule assisted greatly with nest discovery and monitoring. Lisa Petit provided invaluable guidance in designing the sampling regime. G. Shriver and M. Starus provided valuable comments that greatly improved an earlier version of this manuscript. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 43 TC 8 Z9 8 U1 6 U2 49 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 USA SN 0010-5422 EI 1938-5129 J9 CONDOR JI Condor PD MAY PY 2014 VL 116 IS 2 BP 205 EP 214 DI 10.1650/CONDOR-13-045.1 PG 10 WC Ornithology SC Zoology GA AK0ID UT WOS:000338095200006 ER PT J AU Castro-Morales, K Macias-Zamora, JV Canino-Herrera, SR Burke, RA AF Castro-Morales, Karel Vinicio Macias-Zamora, J. Raul Canino-Herrera, S. Burke, Roger A. TI Dissolved methane concentration and flux in the coastal zone of the Southern California Bight-Mexican sector: Possible influence of wastewater SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE methane; coastal zone; outfalls; air-water exchanges; Mexico ID SANTA-BARBARA CHANNEL; GULF-OF-CALIFORNIA; SURFACE WATERS; SEWER SYSTEMS; NORTH-SEA; EMISSIONS; OXIDATION; RIVER; QUANTIFICATION; ATMOSPHERE AB We measured dissolved methane concentrations ([CH4]) in the coastal zone of the Southern California Bight-Mexican sector (SCBMex) during two cruises: S1 in the USA Mexico Border Area (BA) during a short rainstorm and S2 in the entire SCBMex during a drier period a few days later. High spatial variability in surface mixed layer (ML) [CH4] was observed, ranging from 2.2 nmol L-1 to 17.8 nmol L-1 ML[CH4] was supersaturated at all BA stations during both cruises. The highest [CH4] was 72.4 nmol L-1 (2819 % supersaturated) measured at 10 m depth during S2, about 3 km southwest of the discharge point of the South Bay Ocean Outfall (SBOO). Our results show an apparent connection between wastewater treatment discharges and [CH4]. Application of a sewer CH4 production model suggests that the SBOO may be a large source of CH4 to the BA and points to the need to consider point sources in developing coastal marine CH4 budgets for highly populated areas. Based on our data, the SCBMex appears to be a relatively strong source of CH4 to the atmosphere compared to other Pacific Basin areas. The average BA sea-to-air CH4 flux (F) during S1 was (15.5 +/- 8.6) x 10(-2) nmol m(-2) s(-1), about 1.5 times higher than F during S2, which had a flux of (9.5 +/- 6.9) x 10(-2) nmol m-(2) s(-1) mainly due to the higher wind speed during S1. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Castro-Morales, Karel; Raul Canino-Herrera, S.] Univ Autonoma Baja California, Fac Ciencias Marinas, Ensenada 22800, Baja California, Mexico. [Castro-Morales, Karel; Vinicio Macias-Zamora, J.] Inst Invest Oceanol, Ensenada 22800, Baja California, Mexico. [Burke, Roger A.] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Athens, GA 30605 USA. RP Castro-Morales, K (reprint author), Helmholtz Ctr Polar & Marine Res, Alfred Wegener Inst, Handelshafen 12, D-27570 Bremerhaven, Germany. EM karelcm@gmail.com OI Macias-Zamora, Jose Vinicio/0000-0002-8784-7858 FU National Mexican Council for Science and Technology (CONACyT); Autonomous University of Baja California (UABC) FX We would like to thank to the National Mexican Council for Science and Technology (CONACyT) and the 8th internal funding from the Autonomous University of Baja California (UABC), 2004, for providing the funds for this project. KCM give special thanks to the crew of the ORV Alguita. We thank Rebecca Little Owl and Steve Smullen of the IBWC for providing data from and information about the SBIWTP. We thank Dr. Kelly Redmond of the WRCC for providing climate data and helpful discussion about winter storms. Although this work was reviewed by the USEPA and approved for publication, it might not necessarily reflect Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. We acknowledge Prof. Frank Sansone and the anonymous reviewers who contributed greatly to the improvement of this manuscript. NR 66 TC 1 Z9 1 U1 0 U2 10 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 EI 1096-0015 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD MAY 1 PY 2014 VL 144 BP 65 EP 74 DI 10.1016/j.ecss.2014.04.017 PG 10 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA AJ7MS UT WOS:000337881400008 ER PT J AU Gonzalez-Chavez, MDA Miller, B Maldonado-Mendoza, IE Scheckel, K Carrillo-Gonzalez, R AF Gonzalez-Chavez, Ma del Carmen A. Miller, Bradley Eduardo Maldonado-Mendoza, Ignacio Scheckel, Kirk Carrillo-Gonzalez, Rogelio TI Localization and speciation of arsenic in Glomus intraradices by synchrotron radiation spectroscopic analysis SO FUNGAL BIOLOGY LA English DT Article DE Arbuscular mycorrhizal fungi; Arsenate; Arsenite; Reduction; X-ray absorption near edge spectroscopy ID ARBUSCULAR MYCORRHIZAL FUNGI; CONTAMINATED SOIL; PHOSPHATE-TRANSPORT; ROOTS; PLANTS; L.; BIOTRANSFORMATION; TRANSFORMATIONS; BIOREMEDIATION; ACQUISITION AB The protective mechanisms employed by arbuscular mycorrhizal fungi (AMP) to reduce the toxic effects of arsenic on host plants remain partially unknown. The goal of this research was identifying the in situ localization and speciation of arsenic (As) in the AM fungus Rhizophagus intraradices [formerly named Glomus intraradices] exposed to arsenate [As(V)]. By using a two-compartment in vitro fungal cultures of R. intraradices-transformed carrot roots, microspectroscopic X-ray fluorescence (mu-XRF), and microspectroscopic X-ray absorption near edge structure (mu-XANES), we observed that As(V) is absorbed after 1 h in the hyphae of AMP. Three hours after exposure a decrease in the concentration of As was noticed and after 24 and 72 h no detectable As concentrations were perceived suggesting that As taken up was pumped out from the hyphae. No As was detected within the roots or hyphae in the root compartment zone three or 45 h after exposure. This suggests a dual protective mechanism to the plant by rapidly excluding As from the fungus and preventing As translocation to the plant root. mu-XANES data showed that gradual As(V) reduction occurred in the AM hyphae between 1 and 3 h after arsenic exposure and was completed after 6 h. Principal component analysis (PCA) and linear combination fitting (LCF) of mu-XANES data showed that the dominant species after reduction of As (V) by R. intraradices extra-radical hyphal was As (III) complexed with a reduced iron(II) carbonate compound. The second most abundant As species present was As (V) iron hydroxides. The remaining As (III) compounds identified by the LCF analyses suggested these molecules were made of reduced As and S. These results increase our knowledge on the mechanism of As transport in AMP and validate our hypotheses that R. intraradices directly participates in arsenic detoxification. These fungal mechanisms may help AMP colonized plants to increase their tolerance to As at contaminated sites. Published by Elsevier Ltd on behalf of The British Mycological Society. C1 [Gonzalez-Chavez, Ma del Carmen A.; Carrillo-Gonzalez, Rogelio] Colegio Postgrad, Montecillo 56230, Estado De Mexic, Mexico. [Miller, Bradley; Scheckel, Kirk] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45268 USA. [Eduardo Maldonado-Mendoza, Ignacio] Inst Politecn Nacl, Ctr Interdisciplinario Invest Desarrollo Integral, IPN Unidad Sinaloa, Dept Biotecnol Agr, Mexico City, DF, Mexico. RP Miller, B (reprint author), US EPA, Natl Enforcement Invest Ctr, POB 25227, Denver, CO 80225 USA. EM carmeng@colpos.mx; Miller.BradleyW@epa.gov; imaldona@ipn.mx; Scheckel.Kirk@epa.gov; crogelio@colpos.mx OI Scheckel, Kirk/0000-0001-9326-9241 FU Collaborative Research Grant Program Texas AM-CONACyT [2009-021]; Advanced Photon Source (APS) of Argonne National Laboratory (Argonne, IL) [DE_AC02-06CH11357] FX We thank M.Sc. Juan Carlos Martinez-Alvarez for his technical assistance in the preparation of mycorrhizal monoxenic fungal cultures. Critical review from Dr. Richard Loeppert is recognized. This project was partially supported by the Collaborative Research Grant Program Texas A&M-CONACyT (2009-021). This work was performed at the XSD/PNC Sector 20 beamline of the Advanced Photon Source (APS) of Argonne National Laboratory (Argonne, IL) through the contract no. DE_AC02-06CH11357. NR 41 TC 6 Z9 6 U1 4 U2 34 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1878-6146 EI 1878-6162 J9 FUNGAL BIOL-UK JI Fungal Biol. PD MAY-JUN PY 2014 VL 118 IS 5-6 BP 444 EP 452 DI 10.1016/j.funbio.2014.03.002 PG 9 WC Mycology SC Mycology GA AJ7NF UT WOS:000337882700002 ER PT J AU Chiu, WA Campbell, JL Clewell, HJ Zhou, YH Wright, FA Guyton, KZ Rusyn, I AF Chiu, Weihsueh A. Campbell, Jerry L., Jr. Clewell, Harvey J., III Zhou, Yi-Hui Wright, Fred A. Guyton, Kathryn Z. Rusyn, Ivan TI Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID POPULATION VARIABILITY; TRICHLOROACETIC-ACID; DICHLOROACETIC ACID; CHEMICAL TOXICITY; MICE; S-(1,2-DICHLOROVINYL)GLUTATHIONE; S-(1,2-DICHLOROVINYL)-L-CYSTEINE; UNCERTAINTY; IMPACT AB Background: Quantitative estimation of toxicokinetic variability in the human population is a persistent challenge in risk assessment of environmental chemicals. Traditionally, inter-individual differences in the population are accounted for by default assumptions or, in rare cases, are based on human toxicokinetic data. Objectives: We evaluated the utility of genetically diverse mouse strains for estimating toxicokinetic population variability for risk assessment, using trichloroethylene (TCE) metabolism as a case study. Methods: We used data on oxidative and glutathione conjugation metabolism of TCE in 16 inbred and 1 hybrid mouse strains to calibrate and extend existing physiologically based pharmacokinetic (PBPK) models. We added one-compartment models for glutathione metabolites and a two-compartment model for dichloroacetic acid (DCA). We used a Bayesian population analysis of interstrain variability to quantify variability in TCE metabolism. Results: Concentration-time profiles for TCE metabolism to oxidative and glutathione conjugation metabolites varied across strains. Median predictions for the metabolic flux through oxidation were less variable (5-fold range) than that through glutathione conjugation (10-fold range). For oxidative metabolites, median predictions of trichloroacetic acid production were less variable (2-fold range) than DCA production (5-fold range), although the uncertainty bounds for DCA exceeded the predicted variability. Conclusions: Population PBPK modeling of genetically diverse mouse strains can provide useful quantitative estimates of toxicokinetic population variability. When extrapolated to lower doses more relevant to environmental exposures, mouse population-derived variability estimates for TCE metabolism closely matched population variability estimates previously derived from human toxicokinetic studies with TCE, highlighting the utility of mouse interstrain metabolism studies for addressing toxicokinetic variability. C1 [Chiu, Weihsueh A.; Guyton, Kathryn Z.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. [Campbell, Jerry L., Jr.; Clewell, Harvey J., III] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA. [Zhou, Yi-Hui; Wright, Fred A.] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA. [Zhou, Yi-Hui; Wright, Fred A.] N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA. [Rusyn, Ivan] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. RP Rusyn, I (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. EM chiu.weihsueh@epa.gov; iir@unc.edu RI Rusyn, Ivan/S-2426-2016 FU National Institutes of Health [P42 ES005948, R01 ES015241, P30 ES010126]; Oak Ridge Institute for Science and Education fellowships - U.S. Environmental Protection Agency (EPA) FX This research was supported in part by grants from the National Institutes of Health [P42 ES005948 (J.L.C., H.J.C., Y.-H.Z., F.A.W., I.R.), R01 ES015241 (I.R.), and P30 ES010126 (F.A.W., I.R.). I.R was supported, in part, by the Oak Ridge Institute for Science and Education fellowships made available through funding from the U.S. Environmental Protection Agency (EPA). NR 22 TC 5 Z9 5 U1 1 U2 12 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP 456 EP 463 DI 10.1289/ehp.1307623 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300014 PM 24518055 ER PT J AU Wignall, JA Shapiro, AJ Wright, FA Woodruff, TJ Chiu, WA Guyton, KZ Rusyn, I AF Wignall, Jessica A. Shapiro, Andrew J. Wright, Fred A. Woodruff, Tracey J. Chiu, Weihsueh A. Guyton, Kathryn Z. Rusyn, Ivan TI Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID DEVELOPMENTAL TOXICITY; RESPONSE ASSESSMENT; RISK-ASSESSMENT; POINT AB BACKGROUND: Benchmark dose (BMD) modeling computes the dose associated with a prespecified response level. While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, and reporting in human health assessments of chemicals. OBJECTIVES: We aimed to apply a standardized process for conducting BMD modeling to reduce inconsistencies in model fitting and selection. METHODS: We evaluated 880 dose-response data sets for 352 environmental chemicals with existing human health assessments. We calculated benchmark doses and their lower limits [10% extra risk, or change in the mean equal to 1 SD (BMD/L-10/1SD)] for each chemical in a standardized way with prespecified criteria for model fit acceptance. We identified study design features associated with acceptable model fits. RESULTS: We derived values for 255 (72%) of the chemicals. Batch-calculated BMD/L-10/1SD values were significantly and highly correlated (R-2 of 0.95 and 0.83, respectively, n = 42) with PODs previously used in human health assessments, with values similar to reported NOAELs. Specifically, the median ratio of BMDs(10/1SD): NOAELs was 1.96, and the median ratio of BMDLs(10/1SD): NOAELs was 0.89. We also observed a significant trend of increasing model viability with increasing number of dose groups. CONCLUSIONS: BMD/L-10/1SD values can be calculated in a standardized way for use in health assessments on a large number of chemicals and critical effects. This facilitates the exploration of health effects across multiple studies of a given chemical or, when chemicals need to be compared, providing greater transparency and efficiency than current approaches. C1 [Wignall, Jessica A.; Shapiro, Andrew J.; Rusyn, Ivan] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Wright, Fred A.] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Woodruff, Tracey J.] Univ Calif, Sch Med, Dept Obstet Gynecol & Reprod Sci, Oakland, CA USA. [Chiu, Weihsueh A.; Guyton, Kathryn Z.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Rusyn, I (reprint author), Univ N Carolina, 0031 MHRC, Chapel Hill, NC 27599 USA. EM iir@unc.edu RI Rusyn, Ivan/S-2426-2016 FU National Institutes of Health [P42-ES005948]; U.S. Environmental Protection Agency (EPA) [STAR-RD83516601]; Oak Ridge Institute for Science and Education (ORISE) fellowship; U.S. EPA FX This work was funded, in part, by grants from National Institutes of Health (P42-ES005948) and U.S. Environmental Protection Agency (EPA) (STAR-RD83516601). J.A. W and I.R. were supported, in part, by the Oak Ridge Institute for Science and Education (ORISE) fellowship funded by the U.S. EPA. NR 31 TC 17 Z9 17 U1 0 U2 18 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP 499 EP 505 DI 10.1289/ehp.1307539 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300020 PM 24569956 ER PT J AU Sacks, JD Rappold, AG Davis, JA Richardson, DB Waller, AE Luben, TJ AF Sacks, Jason D. Rappold, Ana G. Davis, J. Allen, Jr. Richardson, David B. Waller, Anna E. Luben, Thomas J. TI Influence of Urbanicity and County Characteristics on the Association between Ozone and Asthma Emergency Department Visits in North Carolina SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID AIR-POLLUTION; WILDFIRE SMOKE; EXPOSURE; HEALTH; POLLUTANTS; DOWNSCALER; CANADA; MODELS; OUTPUT; SPACE AB Background: Air pollution epidemiologic studies, often conducted in large metropolitan areas because of proximity to regulatory monitors, are limited in their ability to examine potential associations between air pollution exposures and health effects in rural locations. Methods: Using a time-stratified case-crossover framework, we examined associations between asthma emergency department (ED) visits in North Carolina (2006-2008), collected by a surveillance system, and short-term ozone (O-3) exposures using predicted concentrations from the Community Multiscale Air Quality (CMAQ) model. We estimated associations by county groupings based on four urbanicity classifications (representative of county size and urban proximity) and county health. Results: O3 was associated with asthma ED visits in all-year and warm season (April-October) analyses [ odds ratio (OR) = 1.019; 95% CI: 0.998, 1.040; OR = 1.020; 95% CI: 0.997, 1.044, respectively, for a 20-ppb increase in lag 0-2 days O-3]. The association was strongest in Less Urbanized counties, with no evidence of a positive association in Rural counties. Associations were similar when adjusted for fine particulate matter in copollutant models. Associations were stronger for children (5-17 years of age) compared with other age groups, and for individuals living in counties identified with poorer health status compared with counties that had the highest health rankings, although estimated associations for these subgroups had larger uncertainty. Conclusions: Associations between short-term O3 exposures and asthma ED visits differed by overall county health and urbanicity, with stronger associations in Less Urbanized counties, and no positive association in Rural counties. Results also suggest that children are at increased risk of O-3-related respiratory effects. C1 [Sacks, Jason D.; Davis, J. Allen, Jr.; Luben, Thomas J.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Rappold, Ana G.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Richardson, David B.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Waller, Anna E.] Univ N Carolina, Dept Emergency Med, Chapel Hill, NC USA. RP Sacks, JD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Mailcode B 243-01, Res Triangle Pk, NC 27711 USA. EM sacks.jason@epa.gov FU NIEHS NIH HHS [P30 ES010126] NR 29 TC 17 Z9 18 U1 0 U2 10 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP 506 EP 512 DI 10.1289/ehp.1306940 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300021 PM 24569869 ER PT J AU Yang, GX Bowling, LC AF Yang, Guoxiang Bowling, Laura C. TI Detection of changes in hydrologic system memory associated with urbanization in the Great Lakes region SO WATER RESOURCES RESEARCH LA English DT Article ID UNITED-STATES; HURST PHENOMENON; ENERGY FLUXES; UPPER MIDWEST; TIME-SERIES; MODEL; SCALE; PRECIPITATION; VARIABILITY; SIMULATION AB The change of long memory with urbanization in a regional hydrologic system was investigated using both stochastic time series models and a physically based hydrologic model. Based on observed streamflow at five USGS gauge stations in the Great Lakes region, objective fractional autoregressive integrated moving average (FARIMA) model identification and estimation procedures were used for daily streamflow. The recently improved Variable Infiltration Capacity (VIC) model with urban representation was applied to simulate the water and energy response in 16 basins in the region with various degrees of urbanization. The VIC model was driven by different years' land use/cover maps, including a year 1992 base map, and year 2010 and 2030 maps projected by the Land Transformation Model. The ability of the VIC model to capture long memory of observed daily streamflow was evaluated before applying the FARIMA model to all 16 basins. Overall, the northern portion of the domain generally has larger long-term hydrologic dependence than the southern portion. Simulated streamflow statistics show that the long memory in the hydrologic system has decreased with urbanization. In order to interpret the long memory change with urbanization from a physical point of view, spectral analysis was conducted to examine the spectrum change of soil moisture content with urbanization. The decrease in simulated streamflow long memory relates to the decreased low-frequency power and amplitude of soil moisture in the deep soil layer. The long-term response of surface water systems to urbanization should be considered by water resources and urban planners. C1 [Yang, Guoxiang; Bowling, Laura C.] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA. RP Yang, GX (reprint author), US EPA, Oak Ridge Inst Sci & Educ Fellow, Water Supply & Water Resources Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM yang.gavin@epa.gov RI Yang, Guoxiang/I-5619-2012; Bowling, Laura/B-6963-2013 OI Bowling, Laura/0000-0002-1439-3154 FU NASA [NNG06GC40G] FX We gratefully acknowledge the support of the NASA land cover land use change program (grant NNG06GC40G). We would like to thank Henning Rust, Salvatore Grimaldi, and three anonymous reviewers whose comments led to significant improvement of the manuscript. The land use/cover maps projected from the Land Transformation Model provided by Bryan C. Pijanowski's group at Purdue University are appreciated. NR 42 TC 4 Z9 6 U1 2 U2 27 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD MAY PY 2014 VL 50 IS 5 BP 3750 EP 3763 DI 10.1002/2014WR015339 PG 14 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA AJ4UN UT WOS:000337672900009 ER PT J AU Podhorniak, LV AF Podhorniak, Lynda V. TI The Use of Dispersive Pipet Extraction (DPX) Tips for the Sample Cleanup of Apples, Pears, and Oranges in the Analysis of Formetanate HCl SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article AB The U.S. Environmental Protection Agency Analytical Chemistry Laboratory evaluated the effectiveness of dispersive pipet extraction (DPX) tip cleanup and compared the results with the Quick, Easy, Cheap, Effective, Rugged, and Safe dispersive tube cleanup for the sample preparation of three different fruit matrixes analyzed for formetanate HCl (FHCl). Using LC/MS/MS, the target LOD and the LOQ achieved for FHCl with dispersive tubes, 0.1 and 0.3 ng/g, respectively, were similar to the DPX tip sample cleanup. Recoveries at the LOQ ranged from 94 to 109%. A set of 20-40 samples could be prepared in one working day by one chemist. C1 US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, Ft George G Meade, MD 20755 USA. RP Podhorniak, LV (reprint author), US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. EM Podhorniak.Lynda@epa.gov NR 6 TC 1 Z9 2 U1 2 U2 8 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD MAY-JUN PY 2014 VL 97 IS 3 BP 942 EP 945 DI 10.5740/jaoacint.13-092 PG 4 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA AI8ZT UT WOS:000337216200040 PM 25051648 ER PT J AU Wilson, RA Creed, PA Pinyayev, T Wymer, L Creed, JT AF Wilson, Robert A. Creed, Patricia A. Pinyayev, Tatyana Wymer, Larry Creed, John T. TI Speciation and Preservation of Cr-VI and Cr-III in Finished Drinking Water Matrixes Using Collision Cell Ion Chromatography-Inductively Coupled Plasma-Mass Spectrometry SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; CHROMIUM SPECIATION; ICP-MS; INTERFERENCES; NEBULIZATION; HYPHENATION; SELENIUM; CR(III) AB The polyatomic background at the major isotope of Cr was evaluated as a function of collision cell gas flow rate using three different mobile phases. The stability of Cr-VI was evaluated as a function of solution pH by fortifying samples with enriched Cr-53(VI). The Cr-53(VI) recovery was >= 95% at pH 7.8, but by pH 6.2 a significant amount of the enriched spike was recovered as Cr-53(III)-EDTA. The instability of Cr-III at pHs above 7.8 required that Cr-III be chelated prior to speciation. The concentration of EDTA was optimized by evaluating Cr-III recoveries in six finished drinking waters, a U.S. Geological Survey reference water, and a challenge water fortified with competing matrix cations. If the Cr-III was allowed to precipitate (characteristic of shipping a sample without field preservation), acceptable recoveries of Cr-III required the sample to be heated to 70 degrees C in 10 mM EDTA to quantitatively produce the Cr-III-EDTA complex. The overall preservation/speciation approach was evaluated using an enriched Cr-53(IV) and natural Cr-III in seven drinking water matrixes over a 46 day period. A linear least squares analysis was performed on each water, and the corresponding P-values were estimated. The method detection limits for Cr-III-EDTA and Cr-VI were 0.06 and 0.1 mu g/L, respectively. C1 [Wilson, Robert A.; Creed, Patricia A.; Pinyayev, Tatyana; Wymer, Larry; Creed, John T.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Creed, JT (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr,Mail Stop 593, Cincinnati, OH 45268 USA. EM creed.jack@epa.gov NR 31 TC 0 Z9 0 U1 5 U2 19 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD MAY-JUN PY 2014 VL 97 IS 3 BP 956 EP 962 DI 10.5740/jaoacint.13-319 PG 7 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA AI8ZT UT WOS:000337216200042 PM 25051650 ER PT J AU Fordham, DA Shoemaker, KT Schumaker, NH Akcakaya, HR Clisby, N Brook, BW AF Fordham, Damien A. Shoemaker, Kevin T. Schumaker, Nathan H. Akcakaya, H. Resit Clisby, Nathan Brook, Barry W. TI How interactions between animal movement and landscape processes modify local range dynamics and extinction risk SO BIOLOGY LETTERS LA English DT Article DE dispersal; metapopulation; global change; individual-based model; population viability analysis; species distribution ID CLIMATE-CHANGE; INDIGENOUS HARVEST; PIG PREDATION; CONSERVATION; DISPERSAL; DENSITY AB Forecasts of range dynamics now incorporate many of the mechanisms and interactions that drive species distributions. However, connectivity continues to be simulated using overly simple distance-based dispersal models with little consideration of how the individual behaviour of dispersing organisms interacts with landscape structure (functional connectivity). Here, we link an individual-based model to a niche-population model to test the implications of this omission. We apply this novel approach to a turtle species inhabiting wetlands which are patchily distributed across a tropical savannah, and whose persistence is threatened by two important synergistic drivers of global change: predation by invasive species and over-exploitation. We show that projections of local range dynamics in this study system change substantially when functional connectivity is modelled explicitly. Accounting for functional connectivity in model simulations causes the estimate of extinction risk to increase, and predictions of range contraction to slow. We conclude that models of range dynamics that simulate functional connectivity can reduce an important source of bias in predictions of shifts in species distributions and abundances, especially for organisms whose dispersal behaviours are strongly affected by landscape structure. C1 [Fordham, Damien A.; Clisby, Nathan; Brook, Barry W.] Univ Adelaide, Inst Environm, Adelaide, SA 5005, Australia. [Fordham, Damien A.; Clisby, Nathan; Brook, Barry W.] Univ Adelaide, Sch Earth & Environm Sci, Adelaide, SA 5005, Australia. [Shoemaker, Kevin T.; Akcakaya, H. Resit] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA. [Schumaker, Nathan H.] US EPA, Corvallis, OR 97333 USA. RP Fordham, DA (reprint author), Univ Adelaide, Inst Environm, Adelaide, SA 5005, Australia. EM damien.fordham@adelaide.edu.au RI Brook, Barry/G-2686-2011; Fordham, Damien/E-9255-2013 OI Brook, Barry/0000-0002-2491-1517; Fordham, Damien/0000-0003-2137-5592 FU Australian Research Council [DP1096427, FT100100200, FS110200051]; National Science Foundation [DEB-1146198]; U.S. Environmental Protection Agency (EPA) FX Australian Research Council supported D.A.F., B.W.B. and N.C. (DP1096427, FT100100200 and FS110200051). National Science Foundation supported K.T.S. and H.R.A. (DEB-1146198). The U.S. Environmental Protection Agency (EPA) supported N.H.S. and approved this paper for publication. Approval does not imply the content reflects the views of EPA. NR 20 TC 5 Z9 5 U1 2 U2 44 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1744-9561 EI 1744-957X J9 BIOL LETTERS JI Biol. Lett. PD MAY 1 PY 2014 VL 10 IS 5 AR 20140198 DI 10.1098/rsbl.2014.0198 PG 5 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA AI3SW UT WOS:000336783500011 PM 24806426 ER PT J AU Buse, HY Lu, JR Struewing, IT Ashbolt, NJ AF Buse, Helen Y. Lu, Jingrang Struewing, Ian T. Ashbolt, Nicholas J. TI Eukaryotic diversity in premise drinking water using 18S rDNA sequencing: implications for health risks (vol 20, pg 6351, 2013) SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Correction C1 [Buse, Helen Y.; Struewing, Ian T.] US EPA, Dynamac, Cincinnati, OH 45242 USA. [Lu, Jingrang; Ashbolt, Nicholas J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45242 USA. RP Buse, HY (reprint author), US EPA, Dynamac, 26 W Martin Luther King Dr, Cincinnati, OH 45242 USA. EM buse.helen@epa.gov NR 1 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD MAY PY 2014 VL 21 IS 10 BP 6759 EP 6760 DI 10.1007/s11356-014-2634-0 PG 2 WC Environmental Sciences SC Environmental Sciences & Ecology GA AH7LO UT WOS:000336314900048 ER PT J AU Tang, CL Dennis, RL AF Tang, Chunling Dennis, Robin L. TI How reliable is the offline linkage of Weather Research & Forecasting Model (WRF) and Variable Infiltration Capacity (VIC) model? SO GLOBAL AND PLANETARY CHANGE LA English DT Article DE WRF; VIC; Couple; Climate variables ID ATMOSPHERE COUPLING EXPERIMENT; LAND-SURFACE WATER; PART I; CLIMATE-CHANGE; RIVER-BASIN; SENSITIVITY; HYDROLOGY; SYSTEM; GLACE AB The aim for this research is to evaluate the ability of the offline linkage of Weather Research & Forecasting Model (WRF) and Variable Infiltration Capacity (VIC) model to produce hydrological, e.g. evaporation (ET), soil moisture (SM), runoff, and baseflow. First, the VIC model was run by using observed meteorological data and calibrated in the Upper Mississippi River Basin (UMRB) from 1980 to 2010. Subsequently, a simulation based on an offline linkage of WRF and VIC was performed in the UMRB with the calibrated parameters established above from 2006 to 2009. Standard measured meteorological inputs to VIC were replaced by WRF meteorological variables. A spatiotemporal comparison of offline simulated ET, SM, runoff, and baseflow produced by the VIC calibrated run (base data) and by the offline linkage run was conducted. The results showed that the offline linkage of VIC with WRF was able to achieve good agreement in the simulation of monthly and daily soil moisture, and monthly evaporation. This suggests the VIC linkage should function without causing a large change in the moisture budget. However, the offline linkage showed most disagreement in daily and monthly runoff, and baseflow which is related to errors in WRF precipitation. Published by Elsevier B.V. C1 [Tang, Chunling; Dennis, Robin L.] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. RP Tang, CL (reprint author), US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. EM Tang.Chunling@epamail.epa.gov FU EPA for the research program of Air, Climate, and Energy (ACE) FX This publication was supported by the EPA for the research program of Air, Climate, and Energy (ACE). This paper benefited from the two careful EPA internal reviewers, Dr. Katie Price and Dr. Tom Johnson. We greatly thank Steve Howard for helping with datasets. NR 22 TC 1 Z9 1 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8181 EI 1872-6364 J9 GLOBAL PLANET CHANGE JI Glob. Planet. Change PD MAY PY 2014 VL 116 BP 1 EP 9 DI 10.1016/j.gloplacha.2014.01.014 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA AI2SM UT WOS:000336708400001 ER PT J AU Shuster, WD Dadio, S Drohan, P Losco, R Shaffer, J AF Shuster, W. D. Dadio, S. Drohan, P. Losco, R. Shaffer, J. TI Residential demolition and its impact on vacant lot hydrology: Implications for the management of stormwater and sewer system overflows SO LANDSCAPE AND URBAN PLANNING LA English DT Article DE Vacant lots; Demolition; Green infrastructure; Urban hydrology; Stormwater management AB Increased residential demolitions have made vacant lots a ubiquitous feature of the contemporary urban landscape. Vacant lots may provide ecosystem services such as stormwater runoff capture, but the extent of these functions will be regulated by soil hydrology. We evaluated soil physical and hydrologic characteristics at each of low- (backyard, fenceline) and high-disturbance (within the demolition footprint) positions in 52 vacant lots in Cleveland, OH, which were the result of different eras of demolition process and quality (i.e., pre-1996, post-1996). Penetrometer refusal averaged 56% (range: 15-100%) and was attributed to high concentration of remnant buried debris in anthropogenic backfill soils. Both disturbance level and demolition type significantly regulated infiltration rate to an average of 1.8 cm h(-1) (range: 0.03-10.6 cm h(-1)). Sub-surface saturated hydraulic conductivity (K-sat) averaged higher at 4.0 cm h(-1) (range: 0-68.2 cm h(-1)), was influenced by a significant interaction between both disturbance and demolition factors, and controlled by subsurface soil texture and presence/absence of unconsolidated buried debris. Our observations were synthesized in rainfall-runoff models that simulated average, high- and low-hydrologic functioning, turf-dominated, and a prospective green infrastructure simulation, which indicated that although the typical Cleveland vacant lot is a net producer of runoff volume, straightforward change in demolition policy and process, coupled with reutilization as properly designed and managed infiltration-type green infrastructure may result in a vacant lot that has sufficient capacity for detention of the average annual rainfall volume for a major Midwestern US city. Published by Elsevier B.V. C1 [Shuster, W. D.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Dadio, S.] Cedarville Engn Grp LLC, Coventry, PA 19465 USA. [Drohan, P.] Penn State Univ, University Pk, PA 16802 USA. [Losco, R.] Lanchester Soil Consultants Inc, West Grove, PA 19390 USA. [Shaffer, J.] Ohio State Univ, Sch Nat Resources, Columbus, OH 43210 USA. RP Shuster, WD (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. EM shuster.william@epa.gov; sdadio@cedarvilleeng.com; patdrohan@psu.edu; soildude@comcast.net; jared.shaffer@hotmail.com NR 30 TC 17 Z9 17 U1 6 U2 55 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-2046 EI 1872-6062 J9 LANDSCAPE URBAN PLAN JI Landsc. Urban Plan. PD MAY PY 2014 VL 125 SI SI BP 48 EP 56 DI 10.1016/j.landurbplan.2014.02.003 PG 9 WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban Studies SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban Studies GA AH9ME UT WOS:000336465700005 ER PT J AU Knudsen, TB AF Knudsen, T. B. TI Teratology v2.0: Building a Path Forward SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Knudsen, T. B.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 359 EP 359 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800002 ER PT J AU Leung, MCK Hutson, MS Belmonte, JM Swat, M Sipes, N Baker, NC Spencer, RM Seifert, AW Perreault, SD Glazier, JA Knudsen, TB AF Leung, M. C. K. Hutson, M. S. Belmonte, J. M. Swat, M. Sipes, N. Baker, N. C. Spencer, R. M. Seifert, A. W. Perreault, S. D. Glazier, J. A. Knudsen, T. B. TI Computational Embryology and Predictive Toxicology of Hypospadias SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Leung, M. C. K.; Sipes, N.; Perreault, S. D.; Knudsen, T. B.] US EPA, Res Triangle Pk, NC 27711 USA. [Hutson, M. S.] Vanderbilt Univ, Nashville, TN 37235 USA. [Belmonte, J. M.; Swat, M.; Glazier, J. A.] Indiana Univ, Bloomington, IN USA. [Baker, N. C.; Spencer, R. M.] Lockheed Martin, Res Triangle Pk, NC USA. [Seifert, A. W.] Univ Kentucky, Lexington, KY USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 375 EP 375 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800031 ER PT J AU Hunter, ES Hoopes, MR Jeffay, S Lefew, WR Nichols, HP Rosen, MB AF Hunter, E. S. Hoopes, M. R. Jeffay, S. Lefew, W. R. Nichols, H. P. Rosen, M. B. TI Prediction of Developmental Toxicity Using Mouse Embryonic Stem Cells on Environmental Chemicals SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Hunter, E. S.; Hoopes, M. R.; Jeffay, S.; Lefew, W. R.; Nichols, H. P.; Rosen, M. B.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 376 EP 376 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800033 ER PT J AU Curran, C Sipes, N Charlap, JH Rasoulpour, RJ AF Curran, C. Sipes, N. Charlap, J. H. Rasoulpour, R. J. TI Building a Successful Career in Developmental and Reproductive Toxicology: Part 2 SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Curran, C.] No Kentucky Univ, Highland Hts, KY 41076 USA. [Sipes, N.] US EPA, Res Triangle Pk, NC 27711 USA. [Charlap, J. H.] WIL Res, Ashland, OH USA. [Rasoulpour, R. J.] Dow Chem Co USA, Midland, MI 48674 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 382 EP 382 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800044 ER PT J AU Ahir, BK Sipes, NS Baker, NC Leung, MCK Dewoskin, RS Spencer, RM Judson, RS Martin, MT Knudsen, TB AF Ahir, B. K. Sipes, N. S. Baker, N. C. Leung, M. C. K. Dewoskin, R. S. Spencer, R. M. Judson, R. S. Martin, M. T. Knudsen, T. B. TI Predictive Models of Skeletal Developmental Defects from ToxCast High-Throughput Screening Data SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Ahir, B. K.; Sipes, N. S.; Leung, M. C. K.; Judson, R. S.; Martin, M. T.; Knudsen, T. B.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Baker, N. C.; Spencer, R. M.] Lockheed Martin, Res Triangle Pk, NC USA. [Dewoskin, R. S.] Natl Ctr Environm Assessment, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 391 EP 391 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800059 ER PT J AU Wolf, CJ Fang, M Stapleton, HM Abbott, BD AF Wolf, C. J. Fang, M. Stapleton, H. M. Abbott, B. D. TI Activation of Human Peroxisome Proliferator-Activated Receptor-Gamma (PPAR gamma) by House Dust Extracts SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Wolf, C. J.; Abbott, B. D.] US EPA, Tox Assessment Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA. [Fang, M.; Stapleton, H. M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. NR 0 TC 0 Z9 0 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 393 EP 393 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800064 ER PT J AU Johnson, PI Sutton, P Atchley, D Koustas, E Lam, J Sen, S Robinson, K Axelrad, D Woodruff, TJ AF Johnson, P., I Sutton, P. Atchley, D. Koustas, E. Lam, J. Sen, S. Robinson, K. Axelrad, D. Woodruff, T. J. TI The Navigation Guide Systematic Review Methodology Proof of Concept: PFOA and Fetal Growth SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Johnson, P., I; Sutton, P.; Atchley, D.; Sen, S.; Woodruff, T. J.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Koustas, E.] US EPA, ORISE, Off Policy, Washington, DC 20460 USA. [Lam, J.; Robinson, K.] Johns Hopkins Univ, Baltimore, MD USA. [Axelrad, D.] US EPA, Off Policy, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 395 EP 395 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800067 ER PT J AU Campbell, MA Johnson, PI Vesterinen, HM Kim, AN Koustas, E Atchley, DS Zeise, L Sutton, P Donald, JM Woodruff, TJ AF Campbell, M. A. Johnson, P., I Vesterinen, H. M. Kim, A. N. Koustas, E. Atchley, D. S. Zeise, L. Sutton, P. Donald, J. M. Woodruff, T. J. TI Application of the Navigation Guide Method of Systematic Review to Assessing the Potential Developmental and Reproductive Hazards of Triclosan SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Campbell, M. A.; Kim, A. N.; Zeise, L.; Donald, J. M.] Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Oakland, CA USA. [Campbell, M. A.; Kim, A. N.; Zeise, L.; Donald, J. M.] Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Sacramento, CA USA. [Johnson, P., I; Vesterinen, H. M.; Atchley, D. S.; Sutton, P.; Woodruff, T. J.] Univ Calif San Francisco, Program Reprod Hlth & Environm, Oakland, CA USA. [Koustas, E.] US EPA, Off Policy, Natl Ctr Environm Econ, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 412 EP 412 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800100 ER PT J AU Mccormick, LA Dzubow, RC Davis, M Foos, B AF Mccormick, L. A. Dzubow, R. C. Davis, M. Foos, B. TI Children's Health Risk Assessment at EPA and Its Implications for Policy Decisions and Identifying Data Gaps SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Mccormick, L. A.] Assoc Sch & Programs Publ Hlth, Washington, DC USA. [Dzubow, R. C.; Davis, M.; Foos, B.] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 413 EP 413 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800103 ER PT J AU Sipes, NS Knudsen, TB Firestone, MP Cohen-Hubal, E AF Sipes, N. S. Knudsen, T. B. Firestone, M. P. Cohen-Hubal, E. TI EPA's Children's Environmental Health Roadmap: Applying the 21st Century Vision to Prenatal Development SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Sipes, N. S.; Knudsen, T. B.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Firestone, M. P.] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA. [Cohen-Hubal, E.] US EPA, Chem Safety Sustainabil Res Program, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 426 EP 426 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800128 ER PT J AU Euling, SY Hogan, K Cooper, G Cai, C Blessinger, T Christensen, KY Lorber, M Arzuaga, X Sheth, C Sasso, A Pratt, M Hotchkiss, A Lambert, JC AF Euling, S. Y. Hogan, K. Cooper, G. Cai, C. Blessinger, T. Christensen, K. Y. Lorber, M. Arzuaga, X. Sheth, C. Sasso, A. Pratt, M. Hotchkiss, A. Lambert, J. C. TI Di-isobutyl Phthalate (DIBP) Hazard Identification SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Euling, S. Y.; Hogan, K.; Cooper, G.; Cai, C.; Blessinger, T.; Christensen, K. Y.; Lorber, M.; Arzuaga, X.; Sasso, A.; Pratt, M.] US EPA, NCEA, Washington, DC 20460 USA. [Sheth, C.] US FDA, CDER, Silver Spring, MD USA. [Hotchkiss, A.] US EPA, NCEA, Res Triangle Pk, NC 27711 USA. [Lambert, J. C.] US EPA, NCEA, Cincinnati, OH 45268 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 432 EP 432 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800139 ER PT J AU Prasad, RY Simmons, SO Killius, MG Zucker, RM Kligerman, AD Blackman, CF Fry, RC DeMarini, DM AF Prasad, Raju Y. Simmons, Steven O. Killius, Micaela G. Zucker, Robert M. Kligerman, Andrew D. Blackman, Carl F. Fry, Rebecca C. DeMarini, David M. TI Cellular Interactions and Biological Responses to Titanium Dioxide Nanoparticles in HepG2 and BEAS-2B Cells: Role of Cell Culture Media SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Article DE micronucleus; comet assay; flow cytometry ID SILVER NANOPARTICLES; OXIDATIVE STRESS; ACUTE TOXICITY; DNA-DAMAGE; MICE; GENOTOXICITY; AGGLOMERATION; PARTICLES; EXPOSURE; RATS AB We showed previously that exposure of human lung cells (BEAS-2B) to TiO2 nanoparticles (nano-TiO2) produced micronuclei (MN) only when the final concentration of protein in the cell-culture medium was at least 1%. Nanoparticles localize in the liver; thus, we exposed human liver cells (HepG2) to nano-TiO2 and found the same requirement for MN induction. Nano-TiO2 also formed small agglomerates in medium containing as little as 1% protein and caused cellular interaction as measured by side scatter by flow cytometry and DNA damage (comet assay) in HepG2 cells. Nano-TiO2 also increased the activity of the inflammatory factor NFkB but not of AP1 in a reporter-gene HepG2 cell line. Suspension of nano-TiO2 in medium containing 0.1% protein was sufficient for induction of MN by the nanoparticles in either BEAS-2B or HepG2 cells as long the final concentration of protein in the cell-culture medium was at least 1%. Environ. Mol. Mutagen. 55:336-342, 2014. (c) 2014 Wiley Periodicals, Inc. C1 [Prasad, Raju Y.; Killius, Micaela G.] US EPA, Res Triangle Pk, NC 27711 USA. [Prasad, Raju Y.; Fry, Rebecca C.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC USA. [Simmons, Steven O.; Kligerman, Andrew D.; Blackman, Carl F.; DeMarini, David M.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. [Zucker, Robert M.] US EPA, Toxicol Assessment Div, Res Triangle Pk, NC 27711 USA. RP DeMarini, DM (reprint author), US EPA, B105-03, Res Triangle Pk, NC 27711 USA. EM demarini.david@epa.gov OI Simmons, Steven/0000-0001-9079-1069; Blackman, Carl/0000-0003-3267-5224 FU Intramural research program of the U.S. EPA; NIOSH [2T42OH008673]; Gillings Innovation Laboratory Award from the Gillings School of Global Public Health FX Grant sponsor: Intramural research program of the U.S. EPA.; Grant sponsor: NIOSH; Grant number: 2T42OH008673.; Grant sponsor: Gillings Innovation Laboratory Award from the Gillings School of Global Public Health to Dr. Rebecca Fry. NR 24 TC 11 Z9 11 U1 3 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD MAY PY 2014 VL 55 IS 4 BP 336 EP 342 DI 10.1002/em.21848 PG 7 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA AE1RA UT WOS:000333745800004 PM 24446152 ER PT J AU Wang, HH Burgess, RM Cantwell, MG Portis, LM Perron, MM Wu, FC Ho, KT AF Wang, Huanhua Burgess, Robert M. Cantwell, Mark G. Portis, Lisa M. Perron, Monique M. Wu, Fengchang Ho, Kay T. TI STABILITY AND AGGREGATION OF SILVER AND TITANIUM DIOXIDE NANOPARTICLES IN SEAWATER: ROLE OF SALINITY AND DISSOLVED ORGANIC CARBON SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Stability; Silver; Titanium dioxide; Nanoparticle; Seawater ID SURFACE-CHARGE; NANO-SILVER; TOXICITY; KINETICS; SUSPENSIONS; MONOVALENT; RELEASE; IMPACT; ACID; GAPS AB The behavior and fate of nanoparticles (NPs) in the marine environment are largely unknown and potentially have important environmental and human health implications. The aggregation and fate of NPs in the marine environment are greatly influenced by their interactions with seawater and dissolved organic carbon (DOC). In the present study, the stability and aggregation of 30-nm-diameter silver nanoparticles (AgNPs) capped with citrate and polyvinylpyrrolidone (PVP; AgNP-citrate and AgNP-PVP) and 21-nm-diameter titanium dioxide (TiO2) NPs as affected by seawater salinity and DOC were investigated by measuring hydrodynamic diameters and zeta potentials. The added DOC (in humic acid form) stabilized the 3 types of NPs when the seawater salinities were 5 parts per thousand (ppt), but the stabilizing effect of DOC was reduced by a higher salinity (e.g., 30 ppt). In addition, AgNP-PVP was more stable than AgNP-citrate in seawater, indicating that surface capping agents and stabilization mechanisms govern the stability and aggregation of NPs. Statistical analysis showed that salinity is the most dominant influence on the stability and aggregation of AgNPs and TiO(2)NPs, followed by DOC. These findings expand our knowledge on the behavior of AgNPs and TiO(2)NPs in seawater and indicate that the fate of these NPs will be primarily to aggregate in the water column, precipitate, and accumulate in sediments following release into the marine environment. Environ Toxicol Chem 2014;33:1023-1029. (c) 2014 SETAC C1 [Wang, Huanhua] US EPA, Natl Res Council, Off Res & Dev, Narragansett, RI USA. [Wang, Huanhua; Wu, Fengchang] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing, Peoples R China. [Burgess, Robert M.; Cantwell, Mark G.; Portis, Lisa M.; Ho, Kay T.] US EPA, Off Res & Dev, Narragansett, RI USA. [Perron, Monique M.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. RP Burgess, RM (reprint author), US EPA, Off Res & Dev, Narragansett, RI USA. EM burgess.robert@epa.gov FU US Environmental Protection Agency (USEPA) FX H. Wang was supported by the US Environmental Protection Agency (USEPA) as a National Research Council postdoctoral research associate. The authors thank W. Boothman and B. Taplin at the USEPA (Atlantic Ecology Division, Narragansett, RI) for their assistance in the laboratory. The authors also thank A. Parks, R. McKinney, and K. Rocha for their insightful reviews of the draft manuscript. Mention of trade names of commercial products and companies does not constitute endorsement or recommendation for use. This report has been reviewed by the USEPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the agency. This is USEPA ORD-005072. NR 24 TC 13 Z9 13 U1 7 U2 80 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 2014 VL 33 IS 5 BP 1023 EP 1029 DI 10.1002/etc.2529 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AF1QP UT WOS:000334488700010 PM 24464618 ER PT J AU Rhea, L Shuster, W Shaffer, J Losco, R AF Rhea, L. Shuster, W. Shaffer, J. Losco, R. TI Data proxies for assessment of urban soil suitability to support green infrastructure SO JOURNAL OF SOIL AND WATER CONSERVATION LA English DT Article DE green infrastructure; land cover; soil quality; stormwater management; urban ecosystems ID QUALITY; MANAGEMENT; LANDSCAPE AB Use of urban green infrastructure (GI) such as rain gardens, wetlands, and cisterns is a management option to provide ecosystem services such as storm-water detention, community green space, and pollinator habitat in urban core areas. It would be beneficial to efficiently and inexpensively characterize land parcels for GI suitability We hypothesize that the capability of urban soils to support green infrastructure might be adequately characterized by extant site land cover rather than comparatively expensive and slow soil sampling and testing. As a pilot study, we directly characterized soil taxonomic, physical, and chemical characteristics and measured the percentage of vegetated, bare, and paved land cover for perimeters and interiors of 62 vacant lots and city parks located in Cleveland, Ohio, United States. All vacant lots and park areas were vegetated to some extent, and we were able. to relate surface vegetation to several soil properties. Our results indicate that vegetation is correlated to sandiness, drainage capability, and basic metrics of nutrient availability for these sites, and, that it might be possible with a group of such studies to identify a minimum suite of observations necessary to characterize urban lots in any city for GI suitability C1 [Rhea, L.; Shuster, W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Environm Branch, Cincinnati, OH 45268 USA. [Shaffer, J.] Pegasus Tech Serv Inc, Cincinnati, OH USA. [Losco, R.] Lanchester Soil Consultants Inc, West Grove, PA USA. RP Rhea, L (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Environm Branch, Cincinnati, OH 45268 USA. NR 32 TC 2 Z9 2 U1 6 U2 47 PU SOIL WATER CONSERVATION SOC PI ANKENY PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA SN 0022-4561 EI 1941-3300 J9 J SOIL WATER CONSERV JI J. Soil Water Conserv. PD MAY-JUN PY 2014 VL 69 IS 3 BP 254 EP 265 DI 10.2489/jswc.69.3.254 PG 12 WC Ecology; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA AH5US UT WOS:000336197200012 ER PT J AU Xu, XH Deng, CY Liu, Y He, M Peng, J Wang, T Yuan, L Zheng, ZS Blackshear, PJ Luo, ZG AF Xu, Xiao-Hui Deng, Cai-Yun Liu, Yang He, Miao Peng, Jian Wang, Tong Yuan, Lei Zheng, Zhi-Sheng Blackshear, Perry J. Luo, Zhen-Ge TI MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development SO CELL RESEARCH LA English DT Article DE MARCKS; Rab10; plasmalemmal precursor vesicles; axon growth ID PROTEIN-KINASE-C; MAJOR SPECIFIC SUBSTRATE; NEURONAL POLARIZATION; PLASMA-MEMBRANE; ANTEROGRADE TRANSPORT; IN-VIVO; PHOSPHORYLATION; BRAIN; GROWTH; CELLS AB Axon development requires membrane addition from the intracellular supply, which has been shown to be mediated by Rab10-positive plasmalemmal precursor vesicles (PPVs). However, the molecular mechanisms underlying the membrane trafficking processes of PPVs remain unclear. Here, we show that myristoylated alanine-rich C-kinase substrate (MARCKS) mediates membrane targeting of Rab10-positive PPVs, and this regulation is critical for axon development. We found that the GTP-locked active form of Rab10 binds to membrane-associated MARCKS, whose affinity depends on the phosphorylation status of the MARCKS effector domain. Either genetic silencing of MARCKS or disruption of its interaction with Rab10 inhibited axon growth of cortical neurons, impaired docking and fusion of Rab10 vesicles with the plasma membrane, and consequently caused a loss of membrane insertion of axonal receptors responsive to extracellular axon growth factors. Thus, this study has identified a novel function of MARCKS in mediating membrane targeting of PPVs during axon development. C1 [Xu, Xiao-Hui; Deng, Cai-Yun; Liu, Yang; He, Miao; Peng, Jian; Wang, Tong; Yuan, Lei; Zheng, Zhi-Sheng; Luo, Zhen-Ge] Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China. [Xu, Xiao-Hui; Deng, Cai-Yun; Liu, Yang; He, Miao; Peng, Jian; Wang, Tong; Yuan, Lei; Zheng, Zhi-Sheng; Luo, Zhen-Ge] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China. [Xu, Xiao-Hui] Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China. [Peng, Jian] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China. [Blackshear, Perry J.] Natl Inst Environm Hlth Sci, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA. RP Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China. EM zgluo@ion.ac.cn RI Wang, Tong/O-7351-2015 OI Wang, Tong/0000-0002-3680-8189 FU National Natural Science Foundation of China [31330032, 31321091, 61327902, 81171190]; National Key Basic Research Program of China [2014CB910203]; SA-SIBS Scholarship Program; Shanghai Postdoctoral Scientific Program; China Postdoctoral Science Foundation; KC Wong Education Foundation FX This work was supported by the National Natural Science Foundation of China (31330032, 31321091, and 61327902 to ZG L and 81171190 to XH X) and the National Key Basic Research Program of China (2014CB910203). We thank Dr Q Hu of ION Imaging Facility with microscope analysis and Dr Y Kong with EM analysis. XH X was supported by SA-SIBS Scholarship Program, Shanghai Postdoctoral Scientific Program, China Postdoctoral Science Foundation funded Project, and KC Wong Education Foundation. NR 58 TC 11 Z9 12 U1 4 U2 24 PU INST BIOCHEMISTRY & CELL BIOLOGY PI SHANGHAI PA SIBS, CAS, 319 YUEYANG ROAD, SHANGHAI, 200031, PEOPLES R CHINA SN 1001-0602 EI 1748-7838 J9 CELL RES JI Cell Res. PD MAY PY 2014 VL 24 IS 5 BP 576 EP 594 DI 10.1038/cr.2014.33 PG 19 WC Cell Biology SC Cell Biology GA AH1XI UT WOS:000335914700006 PM 24662485 ER PT J AU Mantey, JA Rekhadevi, PV Diggs, DL Ramesh, A AF Mantey, Jane A. Rekhadevi, Perumalla V. Diggs, Deacqunita L. Ramesh, Aramandla TI Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc (Min) mouse model of colon cancer SO TUMOR BIOLOGY LA English DT Article DE Benzo(a) pyrene; Jejunum; Colon; Liver; Metabolism; Cancer ID POLYCYCLIC AROMATIC-HYDROCARBONS; INTESTINAL EPITHELIAL-CELLS; MITOCHONDRIAL DYSFUNCTION; COLORECTAL ADENOMA; DIETARY-INTAKE; ORAL INTAKE; RISK; RAT; EXPOSURE; CYP1A1 AB Given the fact that increased dietary intake of polycyclic aromatic hydrocarbons (PAHs; a family of environmental toxicants) leads to the formation and development of colon tumors, the ability of the gastrointestinal tract to process these compounds is important from the viewpoint of toxicity/carcinogenesis. Benzo(a)pyrene (BaP), a prototypical PAH compound is released into the environment from automobile exhausts, cigarette smoke, and industrial emissions. Additionally, considerable intake of BaP is expected in people who consume barbecued foods and a diet rich in saturated fat. In exposed animals, BaP becomes activated to potent metabolites that interfere with target organ function and as a consequence cause toxicity and cancer. Therefore, knowledge of BaP metabolism in the digestive system will be of importance in the management of cancers of the digestive tract. The objective of our study was to study the metabolism of BaP by subcellular fractions (nuclear, cytosolic, mitochondrial, and microsomal) of the gastrointestinal tract and liver. Subcellular fractions were isolated by differential centrifugation from the stomach, jejunum, colon, and liver tissues of Apc (Min) mice that received a subchronic dose of 25 mu g/kg BaP. The fractions were incubated with 1 and 3 mu M BaP. Subsequent to incubation, samples were extracted with ethyl acetate and analyzed for BaP metabolites by reverse-phase HPLC equipped with fluorescence detection. Among the different fractions tested, microsomal BaP metabolism was higher than the rest of the fractions in all the samples analyzed. Additionally, a BaP exposure concentration-dependent effect on metabolite levels generated by the subcellular fractions was recorded. The BaP metabolites identified were the following: BaP-9,10-diol; BaP-4,5-diol; BaP-7,8-diol; 9(OH) BaP; 3(OH) BaP; BaP-3,6-dione; and BaP-6,12-dione. While the diol group of metabolites was frequently detected, among diones, the 3,6 and 6,12-dione metabolites were infrequently detected. Among the diol metabolites, the preponderance of BaP-7,8-dihydrodiol is interesting, since this metabolite is a precursor to the DNA-reactive BaP-7,8-dihydrodiol epoxide (BPDE) that has been linked to BaP-induced cancer. C1 [Mantey, Jane A.] Meharry Med Coll, Dept Neurosci & Pharmacol, Nashville, TN 37208 USA. [Rekhadevi, Perumalla V.; Diggs, Deacqunita L.; Ramesh, Aramandla] Meharry Med Coll, Dept Biochem & Canc Biol, Nashville, TN 37208 USA. [Diggs, Deacqunita L.] US EPA, Toxic Assessment Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Ramesh, A (reprint author), Meharry Med Coll, Dept Biochem & Canc Biol, 1005 DB Todd Blvd, Nashville, TN 37208 USA. EM aramesh@mmc.edu FU National Institutes of Health (NIH) [5R01CA142845-04 1F31ES017391-01, 5R25GM059994-11]; US Department of Education FX The authors would like to thank the National Institutes of Health (NIH) grants (5R01CA142845-04 1F31ES017391-01, 5R25GM059994-11), and Title III grant from the US Department of Education for financial support. We thank Dr. Mohammad Niaz for his assistance with dosing of mice and metabolite extractions. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. NR 61 TC 4 Z9 4 U1 1 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1010-4283 EI 1423-0380 J9 TUMOR BIOL JI Tumor Biol. PD MAY PY 2014 VL 35 IS 5 BP 4929 EP 4935 DI 10.1007/s13277-014-1647-0 PG 7 WC Oncology SC Oncology GA AG9SL UT WOS:000335759800115 PM 24477577 ER PT J AU Richardson, VM Ferguson, SS Sey, YM DeVito, MJ AF Richardson, Vicki M. Ferguson, Stephen S. Sey, Yusupha M. DeVito, Michael J. TI In vitro metabolism of thyroxine by rat and human hepatocytes SO XENOBIOTICA LA English DT Article DE Deiodination; glucuronidation; PCB 153; sulfation; thyroid hormone; T-4 ID MICROSOMAL-ENZYME INDUCERS; UDP-GLUCURONOSYLTRANSFERASE INDUCERS; FOLLICULAR CELL-PROLIFERATION; THYROID-HORMONE METABOLISM; POLYCHLORINATED BIPHENYL CONGENERS; BILIARY-EXCRETION; IODOTHYRONINE SULFOTRANSFERASES; CYTOCHROME-P450 ENZYMES; TRIIODOTHYRONINE T-3; GENE-EXPRESSION AB 1. The liver metabolizes thyroxine (T-4) through two major pathways: deiodination and conjugation. Following exposure to xenobiotics, T-4 conjugation increases through the induction of hepatic uridine diphosphate glucuronosyltransferase (UGT) in rodents; however, it is uncertain to what degree different species employ deiodination and conjugation in the metabolism of T-4. The objective of this study was to compare the metabolism of T-4 in untreated and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153)-treated primary sandwich-cultured hepatocytes from rat (SCRH) and human (SCHH). 2. Basal metabolite concentrations were 13 times higher in the medium of SCRH compared to SCHH. Metabolite distribution in the medium of SCRH versus SCHH was as follows: T(4)G, (91.6 versus 5.3%); T4S, (3.6 versus 4.4%) and T-3+rT(3), (4.9 versus 90.3%). PCB 153 induced T(4)G in the medium of SCRH and SCHH; however, T4S and T-3+rT(3) were changed but to a much lesser degree. 3. The results indicate that baseline T-4 glucuronidation is greater in SCRH compared to SCHH. These data also suggest that glucuronidation may be a more important pathway for T4 metabolism in rats and deiodination may be a favored pathway in humans; however, with PCB 153 treatment these data support glucuronidation as a primary route of T-4 metabolism in both rat and humans. C1 [Richardson, Vicki M.; Sey, Yusupha M.] US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27709 USA. [Richardson, Vicki M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA. [Ferguson, Stephen S.] Life Technol, Durham, NC USA. [DeVito, Michael J.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. RP Richardson, VM (reprint author), US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, MD B105-03, Res Triangle Pk, NC 27709 USA. EM richardson.vicki@epa.gov NR 64 TC 6 Z9 7 U1 0 U2 15 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0049-8254 EI 1366-5928 J9 XENOBIOTICA JI Xenobiotica PD MAY PY 2014 VL 44 IS 5 BP 391 EP 403 DI 10.3109/00498254.2013.847990 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AH1OW UT WOS:000335891600001 PM 24175917 ER PT J AU Wolff, NA Ghio, AJ Garrick, LM Garrick, MD Zhao, L Fenton, RA Thevenod, F AF Wolff, Natascha A. Ghio, Andrew J. Garrick, Laura M. Garrick, Michael D. Zhao, Lin Fenton, Robert A. Thevenod, Frank TI Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1) SO FASEB JOURNAL LA English DT Article DE adenine nucleotide translocator; early endosomal antigen 1; kiss-and-run; lysosome-associated membrane protein; transferrin ID KIDNEY PROXIMAL TUBULE; CYTOCHROME-C-OXIDASE; IRON-METABOLISM; SUPEROXIDE-DISMUTASE; MEMBRANE-PROTEINS; EPITHELIAL-CELLS; ION TRANSPORTER; OUTER-MEMBRANE; RAT-KIDNEY; TRAFFICKING AB In mammalian cells, mitochondria receive most incoming iron, yet no entry pathway for iron at the outer mitochondrial membrane (OMM) has been characterized. Our results show that the divalent metal transporter 1 (DMT1) occurs in the OMM. Immunoblots detected DMT1 in mitochondria from a pneumocyte cell model in their OMM. Using the split-ubiquitin yeast 2-hybrid system, we found that cytochrome c oxidase subunit II (COXII) and the translocase of OMM 6-kDa subunit (Tom6) homologue interact with DMT1. COXII coimmunoprecipitates with DMT1. There are 4 DMT1 isoforms that differ at the N and C termini. Using HEK293 cells that inducibly express all of the 4 ends of DMT1, we found all of them in the OMM, as detected by immunoblots after cell fractionation, and in isolated mitochondria, as detected by immunofluorescence. Immunoblot analysis of purified cell fractions from rat renal cortex confirmed and extended these results to the kidney, which expressed high levels of DMT1. Immunogold labeling detected DMT1 colocalization in mitochondria with the voltage-dependent anion-selective channel protein-1, which is expressed in the OMM. We suggest that DMT1 not only exports iron from endosomes, but also serves to import the metal into the mitochondria.Wolff, N. A., Ghio, A. J., Garrick, L. M., Garrick, M. D., Zhao, L., Fenton, R. A., Thevenod, F. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). C1 [Wolff, Natascha A.; Thevenod, Frank] Univ Witten Herdecke, Dept Physiol & Pathophysiol, D-58453 Witten, Germany. [Wolff, Natascha A.; Thevenod, Frank] Univ Witten Herdecke, Ctr Biomed Educ & Res ZBAF, D-58453 Witten, Germany. [Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Chapel Hill, NC USA. [Garrick, Laura M.; Garrick, Michael D.; Zhao, Lin] SUNY Buffalo, Dept Biochem, Buffalo, NY 14214 USA. [Fenton, Robert A.] Aarhus Univ, Dept Biomed, Aarhus, Denmark. [Fenton, Robert A.] Aarhus Univ, Interact Prot Epithelial Transport InterPrET Ctr, Aarhus, Denmark. RP Thevenod, F (reprint author), Univ Witten Herdecke, Dept Physiol & Pathophysiol, Stockumer Str 12, D-58453 Witten, Germany. EM natascha.wolff@uni-wh.de; frank.thevenod@uni-wh.de FU Deutsche Forschungsgemeinschaft (DFG) [TH345/11-1]; Center for Biomedical Education and Research (ZBAF; University of Witten/Herdecke, Witten, Germany); Laura and Michael Garrick Fund; Danish Medical Research Council; Lundbeck Foundation FX The authors thank Dr. Sabine Brast and Dr. Giuliano Ciarimboli for advice regarding the split-ubiquitin yeast 2-hybrid system, Tobias Dreser and Else-Merete Locke for technical assistance, and Dr. Funmei Yang (University of Texas at San Antonio, San Antonio, TX, USA) for assistance in performing the immunoblot in Fig. 1. Access to the Zeiss AxioImager fluorescence microscope was provided by the State University of New York (SUNY) Buffalo Confocal Microscopy Facility (Buffalo, NY, USA). Financial support was obtained from Deutsche Forschungsgemeinschaft (DFG) grant TH345/11-1, The Center for Biomedical Education and Research (ZBAF; University of Witten/Herdecke, Witten, Germany), the Laura and Michael Garrick Fund, the Danish Medical Research Council, and the Lundbeck Foundation. The hDMT1-1A/+IRE plasmids were provided by Dr. Matthias Hentze [European Molecular Biology Laboratory (EMBL), Heidelberg, Germany]. NR 57 TC 9 Z9 10 U1 2 U2 13 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD MAY PY 2014 VL 28 IS 5 BP 2134 EP 2145 DI 10.1096/fj.13-240564 PG 12 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AG3RA UT WOS:000335336000017 PM 24448823 ER PT J AU Buse, HY Lu, JR Lu, XX Mou, XZ Ashbolt, NJ AF Buse, Helen Y. Lu, Jingrang Lu, Xinxin Mou, Xiaozhen Ashbolt, Nicholas J. TI Microbial diversities (16S and 18S rRNA gene pyrosequencing) and environmental pathogens within drinking water biofilms grown on the common premise plumbing materials unplasticized polyvinylchloride and copper SO FEMS MICROBIOLOGY ECOLOGY LA English DT Article DE 16S rRNA gene V4 & V6 region; 18S rRNA gene V1 & V3 region; Acanthamoeba polyphaga; Legionella pneumophila; PVC; Copper ID FREE-LIVING PROTOZOA; DISTRIBUTION-SYSTEM; LEGIONELLA-PNEUMOPHILA; BACTERIAL COMMUNITIES; HARTMANNELLA-VERMIFORMIS; RESISTING BACTERIA; TREATMENT-PLANT; UNITED-STATES; AMEBAS; COLONIZATION AB Drinking water (DW) biofilm communities influence the survival of opportunistic pathogens, yet knowledge about the microbial composition of DW biofilms developed on common in-premise plumbing material is limited. Utilizing 16S and 18S rRNA gene pyrosequencing, this study characterized the microbial community structure within DW biofilms established on unplasticized polyvinyl chloride (uPVC) and copper (Cu) surfaces and the impact of introducing Legionella pneumophila (Lp) and Acanthamoeba polyphaga. Mature (>1year old) biofilms were developed before inoculation with sterilized DW (control, Con), Lp, or Lp and A.polyphaga (LpAp). Comparison of uPVC and Cu biofilms indicated significant differences between bacterial (P=0.001) and eukaryotic (P<0.01) members attributable to the unique presence of several family taxa: Burkholderiaceae, Characeae, Epistylidae, Goniomonadaceae, Paramoebidae, Plasmodiophoridae, Plectidae, Sphenomonadidae, and Toxariaceae within uPVC biofilms; and Enterobacteriaceae, Erythrobacteraceae, Methylophilaceae, Acanthamoebidae, and Chlamydomonadaceae within Cu biofilms. Introduction of Lp alone or with A.polyphaga had no effect on bacterial community profiles (P>0.05) but did affect eukaryotic members (uPVC, P<0.01; Cu, P=0.001). Thus, established DW biofilms host complex communities that may vary based on substratum matrix and maintain consistent bacterial communities despite introduction of Lp, an environmental pathogen. C1 [Buse, Helen Y.] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA. [Lu, Jingrang; Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Lu, Xinxin; Mou, Xiaozhen] Kent State Univ, Dept Biol Sci, Kent, OH 44242 USA. [Ashbolt, Nicholas J.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. RP Buse, HY (reprint author), 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM hybuse@filter24.org NR 59 TC 14 Z9 15 U1 3 U2 58 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0168-6496 EI 1574-6941 J9 FEMS MICROBIOL ECOL JI FEMS Microbiol. Ecol. PD MAY PY 2014 VL 88 IS 2 BP 280 EP 295 DI 10.1111/1574-6941.12294 PG 16 WC Microbiology SC Microbiology GA AG4OA UT WOS:000335398400006 PM 24490699 ER PT J AU Thomas, R Hubbard, AE McHale, CM Zhang, LP Rappaport, SM Lan, Q Rothman, N Vermeulen, R Guyton, KZ Jinot, J Sonawane, BR Smith, MT AF Thomas, Reuben Hubbard, Alan E. McHale, Cliona M. Zhang, Luoping Rappaport, Stephen M. Lan, Qing Rothman, Nathaniel Vermeulen, Roel Guyton, Kathryn Z. Jinot, Jennifer Sonawane, Babasaheb R. Smith, Martyn T. TI Characterization of Changes in Gene Expression and Biochemical Pathways at Low Levels of Benzene Exposure SO PLOS ONE LA English DT Article ID PRINCIPAL COMPONENT ANALYSIS; ACUTE MYELOID-LEUKEMIA; TESTING ASSOCIATION; VARIABLE IMPORTANCE; LONGITUDINAL DATA; BONE-MARROW; METABOLISM; IDENTIFICATION; PHENOL; KEGG AB Benzene, a ubiquitous environmental pollutant, causes acute myeloid leukemia (AML). Recently, through transcriptome profiling of peripheral blood mononuclear cells (PBMC), we reported dose-dependent effects of benzene exposure on gene expression and biochemical pathways in 83 workers exposed across four airborne concentration ranges (from < 1 ppm to > 10 ppm) compared with 42 subjects with non-workplace ambient exposure levels. Here, we further characterize these dose-dependent effects with continuous benzene exposure in all 125 study subjects. We estimated air benzene exposure levels in the 42 environmentally-exposed subjects from their unmetabolized urinary benzene levels. We used a novel nonparametric, data-adaptive model selection method to estimate the change with dose in the expression of each gene. We describe non-parametric approaches to model pathway responses and used these to estimate the dose responses of the AML pathway and 4 other pathways of interest. The response patterns of majority of genes as captured by mean estimates of the first and second principal components of the dose-response for the five pathways and the profiles of 6 AML pathway response-representative genes (identified by clustering) exhibited similar apparent supra-linear responses. Responses at or below 0.1 ppm benzene were observed for altered expression of AML pathway genes and CYP2E1. Together, these data show that benzene alters disease-relevant pathways and genes in a dose-dependent manner, with effects apparent at doses as low as 100 ppb in air. Studies with extensive exposure assessment of subjects exposed in the low-dose range between 10 ppb and 1 ppm are needed to confirm these findings. C1 [Thomas, Reuben; Hubbard, Alan E.; McHale, Cliona M.; Zhang, Luoping; Rappaport, Stephen M.; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Superfund Res Program, Berkeley, CA 94704 USA. [Lan, Qing; Rothman, Nathaniel] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD USA. [Guyton, Kathryn Z.; Jinot, Jennifer; Sonawane, Babasaheb R.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. [Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands. RP Thomas, R (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Superfund Res Program, Berkeley, CA 94704 USA. EM reuben.thomas@berkeley.edu RI Vermeulen, Roel/F-8037-2011 OI Vermeulen, Roel/0000-0003-4082-8163 FU National Institutes of Health, National Institute of Environmental Health Sciences [R01ES01896, P42 ES004705]; Environment Protection Agency [EP-11-001398] FX Original data generated through funding from National Institutes of Health grants R01ES01896 and P42 ES004705 from the National Institute of Environmental Health Sciences with additional statistical analyses being funded in part by Environment Protection Agency contract number EP-11-001398. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 11 Z9 11 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 1 PY 2014 VL 9 IS 5 AR e91828 DI 10.1371/journal.pone.0091828 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AG6EE UT WOS:000335510600005 PM 24786086 ER PT J AU Green, HC Haugland, RA Varma, M Millen, HT Borchardt, MA Field, KG Walters, WA Knight, R Sivaganesan, M Kelty, CA Shanks, OC AF Green, Hyatt C. Haugland, Richard A. Varma, Manju Millen, Hana T. Borchardt, Mark A. Field, Katharine G. Walters, William A. Knight, R. Sivaganesan, Mano Kelty, Catherine A. Shanks, Orin C. TI Improved HF183 Quantitative Real-Time PCR Assay for Characterization of Human Fecal Pollution in Ambient Surface Water Samples SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID 16S RIBOSOMAL-RNA; MICROBIAL SOURCE TRACKING; GENETIC-MARKERS; FRESH-WATER; BACTEROIDES MARKERS; INDICATOR BACTERIA; QPCR; QUANTIFICATION; PERFORMANCE; AMPLIFICATION AB Quantitative real-time PCR (qPCR) assays that target the human-associated HF183 bacterial cluster within members of the genus Bacteroides are among the most widely used methods for the characterization of human fecal pollution in ambient surface waters. In this study, we show that a current TaqMan HF183 qPCR assay (HF183/BFDrev) routinely forms nonspecific amplification products and introduce a modified TaqMan assay (HF183/BacR287) that alleviates this problem. The performance of each qPCR assay was compared in head-to-head experiments investigating limits of detection, analytical precision, predicted hybridization to 16S rRNA gene sequences from a reference database, and relative marker concentrations in fecal and sewage samples. The performance of the modified HF183/BacR287 assay is equal to or improves upon that of the original HF183/BFDrev assay. In addition, a qPCR chemistry designed to combat amplification inhibition and a multiplexed internal amplification control are included. In light of the expanding use of PCR-based methods that rely on the detection of extremely low concentrations of DNA template, such as qPCR and digital PCR, the new TaqMan HF183/BacR287 assay should provide more accurate estimations of human-derived fecal contaminants in ambient surface waters. C1 [Green, Hyatt C.; Sivaganesan, Mano; Kelty, Catherine A.; Shanks, Orin C.] US EPA, Off Res & Dev, Natl Risk Management & Res Lab, Cincinnati, OH 45268 USA. [Haugland, Richard A.; Varma, Manju] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Millen, Hana T.] US Geol Survey, Wisconsin Water Sci Ctr, Marshfield, WI USA. [Borchardt, Mark A.] ARS, USDA, Marshfield, WI USA. [Field, Katharine G.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. [Walters, William A.] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA. [Knight, R.] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA. [Knight, R.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA. RP Shanks, OC (reprint author), US EPA, Off Res & Dev, Natl Risk Management & Res Lab, Cincinnati, OH 45268 USA. EM shanks.orin@epa.gov RI Knight, Rob/D-1299-2010 FU NIGMS NIH HHS [T32 GM008759] NR 41 TC 25 Z9 25 U1 3 U2 33 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAY PY 2014 VL 80 IS 10 BP 3086 EP 3094 DI 10.1128/AEM.04137-13 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AG4JQ UT WOS:000335386200015 PM 24610857 ER PT J AU Holder, AL Hagler, GSW Yelverton, TLB Hays, MD AF Holder, Amara L. Hagler, Gayle S. W. Yelverton, Tiffany L. B. Hays, Michael D. TI On-road black carbon instrument intercomparison and aerosol characteristics by driving environment SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Ultrafine particles; Size distribution; Light absorption; Mobile source ID ULTRAFINE PARTICLE CONCENTRATIONS; DIESEL EXHAUST PARTICLES; SIZE DISTRIBUTIONS; TRANSPORT MICROENVIRONMENTS; GASOLINE VEHICLES; LIGHT-ABSORPTION; EMISSION FACTORS; MIXING STATE; LOS-ANGELES; EXPOSURE AB Large spatial variations of black carbon (BC) concentrations in the on-road and near-road environments necessitate measurements with high spatial resolution to assess exposure accurately. A series of measurements was made comparing the performance of several different BC instruments (Single Particle Soot Photometer, Photo-Acoustic Soot Spectrometer, and Aethalometer) for high time resolution mobile measurements, capable of mapping spatial gradients. All instruments were highly correlated at high time resolution (r(2) = 0.80-0.89 at a 2-s resolution), however the slope ranged from 0.52 to 1.03, with the Single Particle Soot Photometer (SP2) consistently reporting the lowest BC concentrations. BC and ultrafine particle (UFP) concentrations were two-fold higher on the highway compared to surrounding roads with lower traffic counts. The BC size distribution had a mass median diameter of approximately 120 nm, which was smaller and less coated than aged urban BC. Mean UFP and BC concentrations were 2 and 1.4 times greater, respectively, during free flowing traffic on the highway compared with times when there was stop-and-go congestion, providing evidence that transit time is not a good predictor of BC or UFP exposure. Published by Elsevier Ltd. C1 [Holder, Amara L.; Hagler, Gayle S. W.; Yelverton, Tiffany L. B.; Hays, Michael D.] US EPA, Natl Risk Management Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Holder, AL (reprint author), US EPA, Natl Risk Management Lab, Off Res & Dev, 109 TW Alexander Dr RTP, Res Triangle Pk, NC 27709 USA. EM holder.amara@epa.gov; hagler.gayle@epa.gov; yelverton.tiffany@epa.gov; hays.michael@epa.gov RI Hays, Michael/E-6801-2013 OI Hays, Michael/0000-0002-4029-8660 NR 39 TC 9 Z9 9 U1 3 U2 49 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD MAY PY 2014 VL 88 BP 183 EP 191 DI 10.1016/j.atmosenv.2014.01.021 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AG0KL UT WOS:000335104300021 ER PT J AU Friedland, KD Shank, BV Todd, CD McGinnity, P Nye, JA AF Friedland, Kevin D. Shank, Burton V. Todd, Christopher D. McGinnity, Philip Nye, Janet A. TI Differential response of continental stock complexes of Atlantic salmon (Salmo salar) to the Atlantic Multidecadal Oscillation SO JOURNAL OF MARINE SYSTEMS LA English DT Article DE AMO; Atlantic salmon; Climate; Sea surface temperature ID POST-SMOLT GROWTH; LONG-TERM CHANGES; CLIMATE-CHANGE; NORTH-AMERICAN; MARINE FISHES; SUBPOLAR GYRE; CHANGING ENVIRONMENT; WATER TEMPERATURE; WILD POPULATIONS; SOUTHERN EDGE AB Atlantic salmon, Salmo salar, in the North Atlantic are managed as a set of population complexes distributed in North America and Europe. In recent years, these complexes have experienced reduced marine survival and many populations within the complexes are at risk, especially those at the southern ends of the species amphi-Atlantic range. Atlantic salmon is an anadromous fish dividing its life history between residence in freshwater and the marine environment. The freshwater portion of the life history includes spawning and the rearing of juveniles where in-river production has tended to be relatively stable, whereas the first year at sea, termed the post-smolt year, is characterized by more variable rates of mortality. Although their habitats are widely separated geographically along the North Atlantic seaboards, strong recruitment coherence exists between North American and European stock complexes. This recruitment coherence is correlated with ocean temperature variation associated with the Atlantic Multidecadal Oscillation (AMO). The North Atlantic Oscillation (NAO) appears to be relatively unimportant as a driver of salmon abundance. The mechanism determining the link between AMO-related thermal variation and abundance appears to differ fundamentally for the two continental stock groupings. Whereas ocean climate variability during the first springtime months of juvenile salmon migration to sea appears to be important to the survival of North American stocks, summer climate variation appears to be central to adult recruitment variation for European stocks. This contrast in seasonal effects appears to be related to the varying roles of predation pressure and size-related mortality on the continental stock complexes. The anticipated warming due to global climate change will impose thermal conditions on salmon populations outside historical context and challenge the ability of many populations to persist. Published by Elsevier B.V. C1 [Friedland, Kevin D.] NOAA, Natl Marine Fisheries Serv, Narragansett, RI 02882 USA. [Shank, Burton V.] Natl Marine Fisheries Serv, Woods Hole, MA 02543 USA. [Todd, Christopher D.] Univ St Andrews, Scottish Oceans Inst, St Andrews KY16 8LB, Fife, Scotland. [McGinnity, Philip] Natl Univ Ireland Univ Coll Cork, Sch Biol Earth & Environm Sci, Cork, Ireland. [Nye, Janet A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Friedland, KD (reprint author), NOAA, Natl Marine Fisheries Serv, 28 Tarzwell Dr, Narragansett, RI 02882 USA. EM kevin.friedland@noaa.gov RI McGinnity, Philip/P-6781-2015 OI McGinnity, Philip/0000-0001-5199-5632 FU Beaufort Marine Research Award in Fish Population Genetics; Irish Government under Sea Change Programme FX We thank H. Hatun for the provision of the Gyre Index data and comment on interpretation. P. McGinnity was supported by the Beaufort Marine Research Award in Fish Population Genetics funded by the Irish Government under the Sea Change Programme. NR 76 TC 17 Z9 17 U1 8 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-7963 EI 1879-1573 J9 J MARINE SYST JI J. Mar. Syst. PD MAY PY 2014 VL 133 SI SI BP 77 EP 87 DI 10.1016/j.jmarsys.2013.03.003 PG 11 WC Geosciences, Multidisciplinary; Marine & Freshwater Biology; Oceanography SC Geology; Marine & Freshwater Biology; Oceanography GA AG4ZG UT WOS:000335428300008 ER PT J AU Nye, JA Baker, MR Bell, R Kenny, A Kilbourne, KH Friedland, KD Martino, E Stachura, MM Van Houtan, KS Wood, R AF Nye, Janet A. Baker, Matthew R. Bell, Richard Kenny, Andrew Kilbourne, K. Halimeda Friedland, Kevin D. Martino, Edward Stachura, Megan M. Van Houtan, Kyle S. Wood, Robert TI Ecosystem effects of the Atlantic Multidecadal Oscillation SO JOURNAL OF MARINE SYSTEMS LA English DT Article DE Climate variability; Climate change; Ecosystem based management ID WESTERN ENGLISH-CHANNEL; LARGE MARINE ECOSYSTEMS; LONG-TERM SHIFTS; NORTH-ATLANTIC; CLIMATE-CHANGE; GULF-STREAM; ZOOPLANKTON PREY; FISH ASSEMBLAGE; CHESAPEAKE BAY; SUBPOLAR GYRE AB Multidecadal variability in the Atlantic Ocean and its importance to the Earth's climate system has been the subject of study in the physical oceanography field for decades. Only recently, however, has the importance of this variability, termed the Atlantic Multidecadal Oscillation or AMO, been recognized by ecologists as an important factor influencing ecosystem state. A growing body of literature suggests that AMO-related fluctuations are associated with shifts in ecological boundaries, primary productivity, and a number of ecologically and economically important coastal and marine populations across the Atlantic basin. Although the AMO is a basin-wide index of SST, the drivers of ecosystem change encompass more than temperature anomalies and the mode of action differs within each ecosystem. A common theme in assessing ecosystem change indicates that fluctuations in water masses and circulation patterns drive shifts in ecosystem states, but the magnitude and rate of change is dependent on the physical characteristics of the region. Because of the wide ranging geographic effects of the AMO, and considering its multidecadal nature, a more complete understanding of its causes and effects would allow scientists and managers to more effectively inform ecosystem-based management across the Atlantic Basin. (C) 2013 Elsevier B.V. All rights reserved. C1 [Nye, Janet A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Baker, Matthew R.] NOAA, Natl Marine Fisheries Serv, Alaska Fisheries Sci Ctr, Seattle, WA 98115 USA. [Bell, Richard; Friedland, Kevin D.] NOAA, Natl Marine Fisheries Serv, Northeast Fisheries Sci Ctr, Narragansett, RI 02882 USA. [Kenny, Andrew] Ctr Environm Fisheries & Aquaculture Sci, Lowestoft, Suffolk, England. [Kilbourne, K. Halimeda] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA. [Martino, Edward; Wood, Robert] NOAA, Cooperat Oxford Lab, Oxford, MD 21654 USA. [Stachura, Megan M.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA. [Van Houtan, Kyle S.] NOAA, Fisheries Serv, Pacific Isl Fisheries Sci Ctr, Honolulu, HI 96822 USA. [Van Houtan, Kyle S.] Duke Univ, Nicholas Sch Environm & Earth Sci, Durham, NC 27708 USA. RP Nye, JA (reprint author), SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY 11794 USA. EM janetnye@stonybrook.edu RI Kilbourne, Kelly /D-6560-2012; OI Kilbourne, Kelly /0000-0001-7864-8438; Stachura, Megan/0000-0002-5241-2846; Van Houtan, Kyle/0000-0001-5725-1773 FU Atlantic Ecology Division [AED-12-034]; U.S. Environmental Protection Agency; University of Maryland Center for Environmental Science [4725] FX We thank the participants of the ICES AMO workshop (WKAMO) held in June 2011 for thoughtful discussion that contributed to this review. We especially thank M. Ting, A. Gnanadesikan, R. Rykaczewski and Young-Oh Kwon who contributed to making an earlier version of Fig. 2. We also thank M. Alexander, N. Shackell, and H. Walker for thoughtful reviews of this paper. This is contribution number AED-12-034 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency. Although the research described in this article has been funded in part by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. This manuscript is contribution number 4725 of the University of Maryland Center for Environmental Science. NR 130 TC 29 Z9 29 U1 6 U2 48 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-7963 EI 1879-1573 J9 J MARINE SYST JI J. Mar. Syst. PD MAY PY 2014 VL 133 SI SI BP 103 EP 116 DI 10.1016/j.jmarsys.2013.02.006 PG 14 WC Geosciences, Multidisciplinary; Marine & Freshwater Biology; Oceanography SC Geology; Marine & Freshwater Biology; Oceanography GA AG4ZG UT WOS:000335428300010 ER PT J AU Wood, CE Jokinen, MP Johnson, CL Olson, GR Hester, S George, M Chorley, BN Carswell, G Carter, JH Wood, CR Bhat, VS Corton, JC DeAngelo, AB AF Wood, Charles E. Jokinen, Micheal P. Johnson, Crystal L. Olson, Greg R. Hester, Susan George, Michael Chorley, Brian N. Carswell, Gleta Carter, Julia H. Wood, Carmen R. Bhat, Virunya S. Corton, J. Christopher DeAngelo, Anthony B. TI Comparative Time Course Profiles of Phthalate Stereoisomers in Mice SO TOXICOLOGICAL SCIENCES LA English DT Article DE phthalate; mode of action; adverse outcome pathway; carcinogenesis; bioassay; peroxisome proliferator; PPAR alpha; liver; benchmark dose; di(2-ethylhexyl) phthalate (DEHP) ID PROLIFERATOR-ACTIVATED RECEPTORS; PEROXISOME PROLIFERATION; RISK-ASSESSMENT; DI(2-ETHYLHEXYL)PHTHALATE DEHP; CHEMICAL CARCINOGENESIS; OCTYL PHTHALATE; REGULATED GENES; LIVER-TUMORS; CANCER-RISK; RODENT AB More efficient models are needed to assess potential carcinogenicity hazard of environmental chemicals based on early events in tumorigenesis. Here, we investigated time course profiles for key events in an established cancer mode of action. Using a case study approach, we evaluated two reference phthalates, di(2-ethylhexyl) phthalate (DEHP) and its stereoisomer di-n-octyl phthalate (DNOP), across the span of a two-year carcinogenicity bioassay. Male B6C3F1 mice received diets with no phthalate added (control), DEHP at 0.12, 0.60, or 1.20%, or DNOP at 0.10, 0.50, or 1.00% (n = 80-83/group) for up to 104 weeks with six interim evaluations starting at week 4. Mean phthalate doses were 139, 845, and 3147 mg/kg/day for DEHP and 113, 755, and 1281 mg/kg/day for DNOP groups, respectively. Incidence and number of hepatocellular tumors (adenoma and/or carcinoma) were greater at >= 60 weeks for all DEHP groups with time and dose trends, whereas DNOP had no significant effects. Key events supported a peroxisome proliferator-activated receptor alpha (PPAR alpha) mode of action for DEHP, with secondary cytotoxicity at the high dose, whereas DNOP induced modest increases in PPAR alpha activity without proliferative or cytotoxic effects. Threshold estimates for later tumorigenic effects were identified at week 4 for relative liver weight (+ 24%) and PPAR alpha activity (+ 79%) relative to the control group. Benchmark doses (BMDs) for these measures at week 4 clearly distinguished DEHP and DNOP and showed strong concordance with values at later time points and tumorigenic BMDs. Other target sites included testis and kidney, which showed degenerative changes at higher doses of DEHP but not DNOP. Our results highlight marked differences in the chronic toxicity profiles of structurally similar phthalates and demonstrate quantitative relationships between early bioindicators and later tumor outcomes. C1 [Wood, Charles E.; Hester, Susan; George, Michael; Chorley, Brian N.; Carswell, Gleta; Wood, Carmen R.; Corton, J. Christopher; DeAngelo, Anthony B.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. [Jokinen, Micheal P.] Expt Pathol Labs, Res Triangle Pk, NC 27709 USA. [Johnson, Crystal L.] Charles River Labs Pathol Associates, Durham, NC 27703 USA. [Olson, Greg R.] Toxicol Pathol Associates, Jefferson, AR 72079 USA. [Carter, Julia H.] Wood Hudson Canc Res Lab, Newport, KY 41071 USA. [Bhat, Virunya S.] Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA. RP Wood, CE (reprint author), US EPA, MD-B105-03,109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM wood.charles@epa.gov FU U.S. Environmental Protection Agency Office of Research and Development FX U.S. Environmental Protection Agency Office of Research and Development. NR 41 TC 5 Z9 6 U1 0 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD MAY PY 2014 VL 139 IS 1 BP 21 EP 34 DI 10.1093/toxsci/kfu025 PG 14 WC Toxicology SC Toxicology GA AG0ZN UT WOS:000335144600003 PM 24496636 ER PT J AU Sigua, GC Novak, JM Watts, DW Cantrell, KB Shumaker, PD Szogi, AA Johnson, MG AF Sigua, G. C. Novak, J. M. Watts, D. W. Cantrell, K. B. Shumaker, P. D. Szoegi, A. A. Johnson, M. G. TI Carbon mineralization in two ultisols amended with different sources and particle sizes of pyrolyzed biochar SO CHEMOSPHERE LA English DT Article DE Biochar; Mineralization; Pellets; Ultisols; Norfolk soil; Coxville soil ID BLACK CARBON; SOIL; CHARCOAL; TEMPERATURE; OXIDATION; SEQUESTRATION; DECOMPOSITION; BIOENERGY; AMENDMENT; IMPACT AB Biochar produced during pyrolysis has the potential to enhance soil fertility and reduce greenhouse gas emissions. The influence of biochar properties (e.g., particle size) on both short- and long-term carbon (C) mineralization of biochar remains unclear. There is minimal information on the potential effects of biochar particle sizes on their breakdowns by soil microorganism, so it is unknown if the particle size of biochar influences C mineralization rate and/or stability in soils. In order to evaluate the effect of different sources (BS) and particle sizes (BF) of biochar on C loss and/or stability in soils, an incubation study on C mineralization of different biochar sources and particle sizes was established using two soils (ST): Norfolk soil (fine loamy, kaolinitic, thermic, typic Kandiudults) and Coxville soil (fine loamy kaolinitic, thermic, Paleaquults). In separate incubation vessels, these soils were amended with one of two manure-based biochars (poultry litters, PL; swine solids, SS) or one of two lignocellulosic-based biochars (switchgrass, SG; pine chips, PC) which were processed into two particle sizes (dust, <0.42 mm; pellet, >2 mm). The amount of CO2 evolved varied significantly between soils (p <= 0.0001); particle sizes (p <= 0.0001) and the interactions of biochar source (p <= 0.001) and forms of biochars (p <= 0.0001) with soil types. Averaged across soils and sources of biochar, CO2-C evolved from dust-sized biochar (281 mg kg(-1)) was significantly higher than pellet-sized biochar (226 mg kg(-1)). Coxville soils with SS biochar produced the greatest average CO2-C of 428 mg kg(-1) and Norfolk soils with PC had the lowest CO2-C production (93 mg kg(-1)). Measured rates of carbon mineralization also varied with soils and sources of biochar (Norfolk: PL > SS > SG PC; Coxville: PC > SG > SS > PL). The average net CO2-C evolved from the Coxville soils (385 mg kg(-1)) was about threefold more than the CO2-C evolved from the Norfolk soils (123 mg kg(-1)). Our results suggest different particle sizes and sources of biochar as well as soil type influence biochar stability. Published by Elsevier Ltd. C1 [Sigua, G. C.; Novak, J. M.; Watts, D. W.; Cantrell, K. B.; Shumaker, P. D.; Szoegi, A. A.] USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Johnson, M. G.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. RP Sigua, GC (reprint author), USDA ARS CPSWPRC, 2611 West Lucas St, Florence, SC 29501 USA. EM gilbert.sigua@ars.usda.gov FU United States Department of Agriculture-Agricultural Research Service [60-6657-1-204]; United States Environmental Protection Agency [DE-12-92342301-1] FX The information in this article has been funded through an Interagency Agreement between the United States Department of Agriculture-Agricultural Research Service (60-6657-1-204) and the United States Environmental Protection Agency (DE-12-92342301-1). It has been subject to review by scientists of the USDA-ARS-Coastal Plain Research Laboratory and by the National Health and Environment Effects Research Laboratory's Western Ecology Division and approved for journal submission. Approval does not signify that the contents reflect views of the US EPA, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. We thank Carl Trettin for assistance with feedstock collection and Cierra Buckman, Takeyah Powell, and Mr. Jerry Martin II for laboratory assistance. NR 44 TC 28 Z9 28 U1 2 U2 95 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD MAY PY 2014 VL 103 BP 313 EP 321 DI 10.1016/j.chemosphere.2013.12.024 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AF1NZ UT WOS:000334481900040 PM 24397887 ER PT J AU Tong, HY Rappold, AG Caughey, M Hinderliter, AL Graff, DW Berntsen, JH Cascio, WE Devlin, RB Samet, JM AF Tong, Haiyan Rappold, Ana G. Caughey, Melissa Hinderliter, Alan L. Graff, Donald W. Berntsen, Jon H. Cascio, Wayne E. Devlin, Robert B. Samet, James M. TI Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers SO INHALATION TOXICOLOGY LA English DT Article DE Blood pressure; brachial artery ultrasound; diesel exhaust; GSTM1 null; heart rate variability; middle-aged healthy human participants ID HEART-RATE-VARIABILITY; PARTICULATE AIR-POLLUTION; OXIDATIVE STRESS; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY RESPONSES; METABOLIC SYNDROME; EXPOSURE; INHALATION; PARTICLES AB Context: Epidemiological studies have shown an association between the incidence of adverse cardiovascular effects and exposure to ambient particulate matter (PM). Diesel exhaust (DE) is a major contributor to ambient PM and gaseous emissions in urban areas. Objective: This was a pilot study designed to evaluate concentration-dependent effects of short-term exposure to whole DE on the cardiovascular system in order to identify a threshold concentration that can elicit biological responses in healthy human volunteers. Materials and methods: Six healthy middle-aged participants with glutathione-S-transferase-Mu 1 (GSTM1) null genotype underwent sequential exposures to 100 mu g/m(3), 200 mu g/m(3), and 300 mu g/m(3) whole DE generated in real time using an idling diesel truck engine. Exposures were separated by 14 d and each was 2 h in duration. Results: We report concentration-dependent effects of exposure to DE, with 100 mu g/m(3) concentration causing minimal cardiovascular effects, while exposure to 300 mu g/m(3) DE for 2 h resulted in a borderline significant reduction of baseline brachial artery diameter (3.34 +/- 0.27 mm pre-versus 3.23 +/- 0.25mm post-exposure; p = 0.08). Exposure to the highest concentration of DE also resulted in increases of 5 mmHg in diastolic blood pressure as well as a decrease in indices of the frequency domain of heart rate variability (HRV). Discussion and conclusions: These findings demonstrate that acute exposure to relatively high concentrations of DE produces cardiovascular changes in middle-aged GSTM1 null individuals. This study therefore suggests that arterial vasoconstriction and changes in HRV are responses through which traffic-related air pollution increases the risk of adverse cardiovascular outcomes. C1 [Tong, Haiyan; Rappold, Ana G.; Cascio, Wayne E.; Devlin, Robert B.; Samet, James M.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA. [Caughey, Melissa; Hinderliter, Alan L.] Univ N Carolina, Dept Med, Chapel Hill Sch Med, Chapel Hill, NC USA. [Graff, Donald W.] Celerion, Lincoln, NE USA. [Berntsen, Jon H.] TRC Corp, Raleigh, NC USA. RP Tong, HY (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, MD 58D,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Tong.haiyan@epa.gov FU US Environmental Protection Agency Intramural Research Program FX The US Environmental Protection Agency Intramural Research Program supported this research. We thank Maryann Bassett, Tracey Montilla, and Michael Schmitt for their excellent medical and technical assistance in the execution of this study. NR 39 TC 8 Z9 9 U1 2 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD MAY PY 2014 VL 26 IS 6 BP 319 EP 326 DI 10.3109/08958378.2014.889257 PG 8 WC Toxicology SC Toxicology GA AF5IF UT WOS:000334746500001 PM 24655088 ER PT J AU Phillips, LJ Moya, J AF Phillips, Linda J. Moya, Jacqueline TI Exposure factors resources: contrasting EPA's Exposure Factors Handbook with international sources SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE dermal exposure; dietary exposure; inhalation exposure AB Efforts to compile and standardize human exposure factors have resulted in the development of a variety of resources available to the scientific community. For example, the US Environmental Protection Agency (EPA) developed the Exposure factors Handbook and Child-specific Exposure Factors Handbook to promote consistency among its various exposure-assessment activities. The US EPA handbooks are compilations of human exposure factors data, including anthropometric and sociocultural data (e.g., body weights, skin-surface areas, and life expectancy), behavioral data (e.g., non-dietary ingestion rates, activity/time use patterns, and consumer product use), factors that may be influenced by the physiological needs of the body, metabolic activity, and health and weight status (e.g., water and food intake, and inhalation rates), and other factors (e.g., building characteristics). Other countries have engaged in similar efforts to compile and standardize exposure factors for use in exposure and risk assessments. For example, the ExpoFacts database contains data for 30 European Union countries. Australia, Canada, Japan, Korea, and Taiwan have developed, or are developing, documents that provide exposure factors data relevant to their populations. The purpose of this paper is to provide an overview of some of the available exposure factors resources; to explore some of the similarities and differences between the US EPA Exposure Factors Handbook and selected other international resources, and to highlight data gaps and present some considerations for promoting consistency among these resources. C1 [Phillips, Linda J.; Moya, Jacqueline] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Phillips, LJ (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Mailcode 8623P,1200 Penn Ave NW, Washington, DC 20460 USA. EM phillips.linda@epa.gov NR 35 TC 3 Z9 3 U1 1 U2 14 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAY-JUN PY 2014 VL 24 IS 3 BP 233 EP 243 DI 10.1038/jes.2013.17 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AF2VQ UT WOS:000334571000002 PM 23611905 ER PT J AU Vallerol, D Isukapalli, S AF Vallerol, Daniel Isukapalli, Sastry TI Simulating real-world exposures during emergency events: studying effects of indoor and outdoor releases in the Urban Dispersion Program in upper Manhattan, NY SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE personal exposure; perfluorocarbon tracers; Urban Dispersion Program; neighborhood activities; indoor/outdoor dynamics ID OKLAHOMA-CITY; PERFLUOROCARBON TRACERS; MODEL; AREAS; FLOW AB A prospective personal exposure study, involving indoor and outdoor releases, was conducted in upper Midtown Manhattan in New York City as part of the Urban Dispersion Program (UDP) focusing on atmospheric dispersion of chemicals in complex urban settings. The UDP experiments involved releases of very low levels of perfluorocarbon tracers (PFTs) in Midtown Manhattan at separate locations, during two seasons in 2005. The study presented here includes both outdoor and indoor releases of the tracers, and realistic scripted activities for characterizing near source and neighborhood-scale exposures using 1-min and 10-min duration samples, respectively. Results showed that distributions of individual tracers and exposures to them within the study area were significantly influenced by surface winds, urban terrain, and movements of people typical of urban centers. Although in general, PFT levels returned quickly to zero in general after cessation of the emissions, in some cases, the concentrations stayed at higher levels after the releases stopped. This is likely due to accumulation of the PFTs in some buildings, which then serve as "secondary sources" when outside levels are lower than indoor levels. Measurements of neighborhood-scale PFT concentrations (up to distances of several blocks away from the release points) provided information needed to establish a baseline for determining how different types of releases could affect exposures both to the general public and to emergency responders. These data highlight the factors impacting the toxic threat levels following releases of hazardous chemicals and provide supporting information for evaluating and refining protocols for emergency event response. C1 [Vallerol, Daniel] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA. [Isukapalli, Sastry] Robert Wood Johnson Med Sch, EOHSI, Piscataway, NJ USA. RP Vallerol, D (reprint author), US EPA, Natl Exposure Res Lab, NERL, Res Triangle Pk, NC 27711 USA. EM Vallero.Daniel@epamail.epa.gov FU United States Environmental Protection Agency through its Office of Research and Development (ORD) [CR 83162501, EPD 04068]; Battelle Memorial Institute FX The United States Environmental Protection Agency through its Office of Research and Development (ORD) partially funded and collaborated in the research described here under assistance agreement CR 83162501 to the Environmental and Occupational Health Sciences Institute, and funded the PFT analyses under contract EPD 04068 with Battelle Memorial Institute and its subcontractor, BNL. The research and the manuscript have been subjected to Agency review and approved for publication. NR 26 TC 2 Z9 2 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAY-JUN PY 2014 VL 24 IS 3 BP 279 EP 289 DI 10.1038/jes.2013.38 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AF2VQ UT WOS:000334571000007 PM 23860401 ER PT J AU Selvakumar, A Tuccillo, ME Martel, KD Matthews, JC Feeney, C AF Selvakumar, Ariamalar Tuccillo, Mary Ellen Martel, Katherine D. Matthews, John C. Feeney, Chris TI Demonstration and Evaluation of State-of-the-Art Wastewater Collection Systems Condition Assessment Technologies SO JOURNAL OF PIPELINE SYSTEMS ENGINEERING AND PRACTICE LA English DT Article DE Condition assessment; Wastewater collection pipes; CCTV; Zoom camera; Electroscanning; Digital scanning; Sonar; Laser scanning ID INFRASTRUCTURE AB Condition assessment of wastewater collection systems is a vital part of a utility's asset management program. Reliable information on pipe condition is needed to prioritize rehabilitation and replacement projects, given the current state of our nation's infrastructure. Although inspections with conventional closed-circuit television (CCTV) have been the mainstay of pipeline condition assessment for decades, other technologies are now commercially available. Five of these innovative technologies were selected for field trials under the U. S. Environmental Protection Agency (USEPA) demonstration program: zoom camera, electroscanning, digital scanning, laser profiling, and sonar. The goal of the field demonstration was to evaluate the technical performance and cost of these technologies. The field demonstration was conducted in August 2010 and was hosted by the Kansas City, Missouri Water Services Department. The innovative technologies were compared to CCTV inspection. Each technology identified maintenance and structural defects by collecting data or images of the pipe condition. The camera technologies (i.e., digital scanning, zoom camera, and CCTV) and laser scanning provided pipe condition above the water line, whereas sonar assessed conditions below the water line. Electroscanning detected leakage-related defects anywhere along the pipe circumference. Costs were compared for different inspection technologies based on actual costs for planning, field work, data analysis, and reporting. Total costs for the multisensor (digital, laser, and sonar scanning) inspection were $14.71 per m of pipeline inspected as compared to $10.31 per m for electroscanning, $3.46 per m for zoom camera, and $9.78 to $10.48 per m for CCTV. (C) 2013 American Society of Civil Engineers. C1 [Selvakumar, Ariamalar] US EPA, Urban Watershed Management Branch, Water Supply & Water Resources Div, Natl Risk Management Res Lab, Edison, NJ 08837 USA. [Tuccillo, Mary Ellen] Cadmus Grp Inc, Watertown, MA 02478 USA. [Martel, Katherine D.] Cadmus Grp Inc, Steep Falls, ME 04085 USA. [Matthews, John C.] Battelle Mem Inst, Baton Rouge, LA 70808 USA. Louis Berger Grp Inc, Environm Engn, Providence, RI 02901 USA. RP Selvakumar, A (reprint author), US EPA, Urban Watershed Management Branch, Water Supply & Water Resources Div, Natl Risk Management Res Lab, 2890 Woodbridge Ave,MS-104, Edison, NJ 08837 USA. EM selvakumar.ariamalar@epa.gov; MaryEllen.Tuccillo@cadmusgroup.com; Katherine.Martel@cadmusgroup.com; Matthewsj@battelle.org; cfeeney@louisberger.com FU U.S. Environmental Protection Agency, through Office of Research and Development FX This paper was developed based on the USEPA report entitled "Field demonstration of condition assessment technologies for wastewater collection systems" http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P100C8E0.txt. The U.S. Environmental Protection Agency, through its Office of Research and Development, funded, managed, and collaborated in the research described herein. It has been subjected to the agency's peer and administrative reviews and has been approved for publication. Any opinions expressed in this report are those of the author(s) and do not necessarily reflect the views of the agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 46 TC 0 Z9 0 U1 2 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1949-1190 EI 1949-1204 J9 J PIPELINE SYST ENG JI J. Pipel. Syst. Eng. Pract. PD MAY PY 2014 VL 5 IS 2 AR 04013018 DI 10.1061/(ASCE)PS.1949-1204.0000161 PG 11 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AF3BY UT WOS:000334587700005 ER PT J AU Huang, JQ Goltz, MN AF Huang, Junqi Goltz, Mark Neil TI Spatial Moment Equations for a Groundwater Plume with Degradation and Rate-Limited Sorption SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Groundwater quality; Mathematical models; Degradation; Sorption; Transport phenomena; Dispersion; Groundwater pollution; Advection ID SOLUTE TRANSPORT; NONEQUILIBRIUM AB In this paper, the authors analytically derive the solution for the spatial moments of groundwater solute concentration distributions simulated by a one-dimensional model that assumes advective-dispersive transport with first-order degradation and rate-limited sorption. Sorption kinetics are assumed to be governed by a first-order rate model, and degradation is assumed to occur in the aqueous (i.e.,mobile) phase only. As an extension of a previously published moment analysis of a model with similar assumptions, an explicit analytical solution is presented for the zeroth, first, and second spatial moments, as well as equations that describe the behavior of the first and second moments at long times. Moment simulations show that when the degradation rate is relatively large compared to the sorption rate, there are time periods in which the first and second spatial moments of the solute concentration distribution (the mean and variance, respectively) decrease over time. At long times, it is seen that the first and second moments increase linearly with time, indicating that velocity and dispersion are constant. C1 [Huang, Junqi] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74821 USA. [Goltz, Mark Neil] US Air Force, Dept Syst Engn & Management, Inst Technol, Wright Patterson AFB, OH 45433 USA. RP Goltz, MN (reprint author), US Air Force, Dept Syst Engn & Management, Inst Technol, 2950 Hobson Way,Bldg 640, Wright Patterson AFB, OH 45433 USA. EM huang.junqi@epa.gov; mark.goltz@afit.edu FU Strategic Environmental Research and Development Program (SERDP) [ER-1737] FX The authors appreciate the very helpful comments of two anonymous reviewers. Financial support was provided by Strategic Environmental Research and Development Program (SERDP) Project ER-1737. Any opinions expressed in this paper are those of the authors and do not, necessarily, reflect the official positions and policies of the U.S. EPA, the United States Air Force, Department of Defense, nor the U.S. government. Any mention of products or trade names does not constitute recommendation for use by the U.S. EPA. NR 11 TC 0 Z9 0 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD MAY 1 PY 2014 VL 19 IS 5 BP 1053 EP 1058 DI 10.1061/(ASCE)HE.1943-5584.0000885 PG 6 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AE9SA UT WOS:000334348100020 ER PT J AU Klosterman, ST Uber, JG Murray, R Boccelli, DL AF Klosterman, Stephen T. Uber, James G. Murray, Regan Boccelli, Dominic L. TI Adsorption Model for Arsenate Transport in Corroded Iron Pipes with Application to a Simulated Intrusion in a Water Distribution Network SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Arsenate; Simulation; Modeling; Arsenic; Contamination; Water distribution system; Adsorption ID DISTRIBUTION-SYSTEMS; SURFACE-DIFFUSION; KINETICS; DESORPTION; HYDROXIDE; CORROSION; SORPTION; OXIDES; WALL; FE AB Adsorption to pipe wall materials significantly affects the fate and transport of certain contaminants in water distribution systems. For example, arsenate has a strong affinity for iron oxide, a substance common in water distribution pipes. In this paper a mathematical model for arsenate adsorption to iron oxide pipe wall materials is developed. The effects of two common assumptions on modeled arsenate transport are explored: a theoretical smooth pipe mass transfer coefficient and an assumption of rapid equilibrium of adsorption at the pipe wall surface. The effects of these assumptions are explored in a single pipe sensitivity analysis and found to yield significantly different results than parameters estimated from experimental data. In simulations of a hypothetical arsenate contamination event in a model water distribution system, the two assumptions result in different predictions of system contamination and contaminant exposure to consumers. These results indicate that even though water quality modeling plays an essential role in planning for distribution system decontamination, modeling assumptions must be carefully chosen. C1 [Klosterman, Stephen T.] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 01238 USA. [Uber, James G.; Boccelli, Dominic L.] Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Environm Engn Program, Engn Res Ctr 701, Cincinnati, OH 45221 USA. [Murray, Regan] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. RP Klosterman, ST (reprint author), Harvard Univ, Dept Organism & Evolutionary Biol, 22 Divin Ave, Cambridge, MA 01238 USA. EM klosterman@fas.harvard.edu FU U.S. Environmental Protection Agency through its Office of Research and Development; Oak Ridge National Laboratory FX The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under an InterAgency Agreement with Oak Ridge National Laboratory. It has been subjected to the Agency's review and has been approved for publication. The contents do not necessarily reflect the views of the Agency. NR 38 TC 0 Z9 0 U1 2 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PLAN MAN JI J. Water Resour. Plan. Manage.-ASCE PD MAY 1 PY 2014 VL 140 IS 5 BP 649 EP 657 DI 10.1061/(ASCE)WR.1943-5452.0000353 PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AF1AF UT WOS:000334445800010 ER PT J AU Zhang, XS Sahajpal, R Manowitz, DH Zhao, KG LeDuc, SD Xu, M Xiong, W Zhang, AP Izaurralde, RC Thomson, AM West, TO Post, WM AF Zhang, Xuesong Sahajpal, Ritvik Manowitz, David H. Zhao, Kaiguang LeDuc, Stephen D. Xu, Min Xiong, Wei Zhang, Aiping Izaurralde, Roberto C. Thomson, Allison M. West, Tristram O. Post, Wilfred M. TI Multi-scale geospatial agroecosystem modeling: A case study on the influence of soil data resolution on carbon budget estimates SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Climate change; Net Ecosystem Production; EPIC; Parallel computing; Spatial resolution; SSURGO; STATSGO ID SURVEY GEOGRAPHIC DATABASE; WATER ASSESSMENT-TOOL; LAND-USE; LONG-TERM; SEQUESTRATION; SUSTAINABILITY; DYNAMICS; SCALE; CROPLANDS; BIOFUELS AB The development of effective measures to stabilize atmospheric CO2 concentration and mitigate negative impacts of climate change requires accurate quantification of the spatial variation and magnitude of the terrestrial carbon (C) flux. However, the spatial pattern and strength of terrestrial C sinks and sources remain uncertain. In this study, we designed a spatially-explicit agroecosystem modeling system by integrating the Environmental Policy Integrated Climate (EPIC) model with multiple sources of geospatial and surveyed datasets (including crop type map, elevation, climate forcing, fertilizer application, tillage type and distribution, and crop planting and harvesting date), and applied it to examine the sensitivity of cropland C flux simulations to two widely used soil databases (i.e. State Soil Geographic-STATSGO of a scale of 1:250,000 and Soil Survey Geographic-SSURGO of a scale of 1:24,000) in Iowa, USA. To efficiently execute numerous EPIC runs resulting from the use of high resolution spatial data (56 m), we developed a parallelized version of EPIC. Both STATSGO and SSURGO led to similar simulations of crop yields and Net Ecosystem Production (NEP) estimates at the State level. However, substantial differences were observed at the county and sub-county (grid) levels. In general, the fine resolution SSURGO data outperformed the coarse resolution STATSGO data for county-scale crop-yield simulation, and within STATSGO, the area-weighted approach provided more accurate results. Further analysis showed that spatial distribution and magnitude of simulated NEP were more sensitive to the resolution difference between SSURGO and STATSGO at the county or grid scale. For over 60% of the cropland areas in Iowa, the deviations between STATSGO- and SSURGO-derived NEP were larger than 1 Mg C ha(-1) yr(-1), or about half of the average cropland NEP, highlighting the significant uncertainty in spatial distribution and magnitude of simulated C fluxes resulting from differences in soil data resolution. (C) 2014 Elsevier B.V. All rights reserved. C1 [Zhang, Xuesong; Manowitz, David H.; Izaurralde, Roberto C.; Thomson, Allison M.; West, Tristram O.] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA. [Zhang, Xuesong; Manowitz, David H.; Izaurralde, Roberto C.; Thomson, Allison M.; West, Tristram O.] Univ Maryland, College Pk, MD 20740 USA. [Sahajpal, Ritvik; Izaurralde, Roberto C.] Univ Maryland, Dept Geog Sci, College Pk, MD 20740 USA. [Zhao, Kaiguang] Ohio State Univ, Sch Environm & Nat Resources, Ohio Agr Res & Dev Ctr, Wooster, OH 44691 USA. [LeDuc, Stephen D.] US EPA, Natl Ctr Environm Assessment, Arlington, VA 22202 USA. [Xu, Min] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA. [Xiong, Wei; Zhang, Aiping] Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China. [Post, Wilfred M.] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. RP Zhang, XS (reprint author), Pacific NW Natl Lab, Joint Global Change Res Inst, 5825 Univ Res Court,Suite 1200, College Pk, MD 20740 USA. EM xuesong.zhang@pnnl.gov RI Thomson, Allison/B-1254-2010; xiong, wei/O-1782-2014; Zhao, Kaiguang/D-1172-2010; zhang, xuesong/B-7907-2009; OI sahajpal, ritvik/0000-0002-6418-289X; Xu, Min/0000-0003-3443-0300 FU DOE Great Lakes Bioenergy Research Center [DE-FC02-07ER64494, KP1601050, DOE EERE OBP 20469-19145]; NASA [NNH08ZDA001N, NNH12AU031]; USDA [CSREES-2009-34263-19774 (G-1449-1), NIFA-2010-34263-21075 (G-1470-3)] FX We sincerely appreciate the valuable comments provided by the anonymous reviewers, which greatly improved the quality of this paper. This work was partially funded by the DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science DE-FC02-07ER64494, DOE BER Office of Science KP1601050, DOE EERE OBP 20469-19145), NASA (NNH08ZDA001N and NNH12AU031), and USDA (CSREES-2009-34263-19774 (G-1449-1) and NIFA-2010-34263-21075 (G-1470-3)). The views expressed here are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 58 TC 12 Z9 12 U1 0 U2 45 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD MAY 1 PY 2014 VL 479 BP 138 EP 150 DI 10.1016/j.scitotenv.2014.01.099 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE5CZ UT WOS:000334006700017 PM 24561293 ER PT J AU Li, D Seaman, JC Chang, HS Jaffe, PR van Groos, PK Jiang, DT Chen, N Lin, JR Arthur, Z Pan, YM Scheckel, KG Newville, M Lanzirotti, A Kaplan, DI AF Li, Dien Seaman, John C. Chang, Hyun-Shik Jaffe, Peter R. van Groos, Paul Koster Jiang, De-Tong Chen, Ning Lin, Jinru Arthur, Zachary Pan, Yuanming Scheckel, Kirk G. Newville, Matthew Lanzirotti, Antonio Kaplan, Daniel I. TI Retention and chemical speciation of uranium in an oxidized wetland sediment from the Savannah River Site SO JOURNAL OF ENVIRONMENTAL RADIOACTIVITY LA English DT Article DE Wetland sediments; Uranium; Chemical speciation; Retention; Spectroscopy ID RAY-ABSORPTION-SPECTROSCOPY; ENVIRONMENTAL-IMPACT ASSESSMENT; CONTAMINATED SEDIMENTS; WASTE-WATER; ADSORPTION; REDUCTION; SOILS; IMMOBILIZATION; RADIONUCLIDES; OXYHYDROXIDES AB Uranium speciation and retention mechanisms onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction, U La-edge X-ray absorption near-edge structure (XANES) spectroscopy, fluorescence mapping and mu-XANES. Under oxidized conditions, U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH < 4 and pH > 8. Sequential extraction indicated that the U species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and organic fraction (Na-pyrophosphate extractable). Uranium L-3-edge XANES spectra of the U-bound sediments were nearly identical to that of uranyl acetate. Based on fluorescence mapping, U and Fe distributions in the sediment were poorly correlated, U was distributed throughout the sample and did not appear as isolated U mineral phases. The primary oxidation state of U in these oxidized sediments was U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species or to secondary mineral formation. Collectively, this study suggests that U may be strongly bound to wetland sediments, not only under reducing conditions by reductive precipitation, but also under oxidizing conditions through NOM-uranium bonding. Published by Elsevier Ltd. C1 [Li, Dien; Kaplan, Daniel I.] Savannah River Natl Lab, Aiken, SC 29808 USA. [Seaman, John C.; Chang, Hyun-Shik] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA. [Jaffe, Peter R.; van Groos, Paul Koster] Princeton Univ, Dept Civil & Environm Engn, Princeton, NJ 08544 USA. [Jiang, De-Tong; Arthur, Zachary] Univ Guelph, Dept Phys, Guelph, ON N1G 2W1, Canada. [Chen, Ning] Canadian Light Source Inc, Saskatoon, SK S7N 2V3, Canada. [Lin, Jinru; Pan, Yuanming] Univ Saskatchewan, Saskatoon, SK S7N 5E2, Canada. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Newville, Matthew; Lanzirotti, Antonio] Univ Chicago, Chicago, IL 60637 USA. RP Li, D (reprint author), Savannah River Natl Lab, Aiken, SC 29808 USA. EM Dien.Li@srs.gov RI Li, Dien/N-6370-2014; OI Scheckel, Kirk/0000-0001-9326-9241; Pan, Yuanming/0000-0002-9195-3776 FU Department of Energy, Environmental Management and Office of Sciences; U.S. Department of Energy [DE-AC09-96SR18500, DE-SC0006847]; Savannah River Ecology Laboratory through a Financial Assistance Award from DOE [DE-FC09-07SR22506]; EPA; National Science Foundation's Earth Sciences [EAR-0217473]; Department of Energy's Geosciences [DE-FG02-94ER14466]; State of Illinois; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-ENG-38] FX This work was supported by Department of Energy, Environmental Management and Office of Sciences. Work was conducted at the Savannah River National Laboratory under the U.S. Department of Energy Contract DE-AC09-96SR18500. Participation of Drs. J.C. Seaman and H.S. Chang in the current study was supported by the Savannah River Ecology Laboratory through a Financial Assistance Award DE-FC09-07SR22506 from DOE to the University of Georgia Research Foundation. Work was conducted at Princeton University under the U.S. Department of Energy Contract DE-SC0006847. Although EPA contributed to this article, the research presented was not directly performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. U L3-edge XANES spectral measurements were performed at the Canadian Light Source, which is supported by the Natural Sciences and Engineering Research Council of Canada, the National Research Council Canada, the Canadian Institutes of Health Research, the Province of Saskatchewan, Western Economic Diversification Canada, and the University of Saskatchewan. GeoSoilEnviroCARS is supported by the National Science Foundation's Earth Sciences (EAR-0217473), Department of Energy's Geosciences (DE-FG02-94ER14466), and the State of Illinois. Use of the APS was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract no. W-31-109-ENG-38. The authors appreciate Savannah Harris and Diana Soteropoulos, University of Georgia, for their assistance with ICP-MS analysis. NR 41 TC 12 Z9 12 U1 8 U2 70 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0265-931X EI 1879-1700 J9 J ENVIRON RADIOACTIV JI J. Environ. Radioact. PD MAY PY 2014 VL 131 SI SI BP 40 EP 46 DI 10.1016/j.jenvrad.2013.10.017 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE5CK UT WOS:000334005200005 PM 24238918 ER PT J AU Wickham, JD Wade, TG Norton, DJ AF Wickham, J. D. Wade, T. G. Norton, D. J. TI Spatial patterns of watershed impervious cover relative to stream location SO ECOLOGICAL INDICATORS LA English DT Article DE Change detection; Clean Water Act (CWA); NLCD; Roads; Urbanization; Water quality ID HEADWATER STREAMS; SURFACE-AREA; URBAN; URBANIZATION; LANDSCAPES; MANAGEMENT; NITROGEN; IMPACTS; FISH AB The urban stream syndrome may not be limited to streams in urbanized watersheds. We measured the spatial pattern of impervious cover in similar to 82,800 small watersheds across the conterminous United States by comparing watershed-based and stream-based measures of imperviousness. The watershed-based measure was the commonly used watershed percentage impervious cover. The stream-based measure was the percentage of watershed stream length flowing through impervious cover. Spatial pattern of impervious cover was classified on a watershed basis as proximal to streams, distal to streams, and uniform by comparing the two measures of impervious cover. We used a classification threshold of +/- 5% to assign watersheds to the three classes (i.e., stream-based minus watershed-based >= 5% = proximal; watershed-based minus stream-based >= 5% = distal; else = uniform). We then applied the classification to two impervious cover thresholds, >= 5% and >= 15%. For >= 5% and >= 15% thresholds, impervious cover was distributed uniformly across similar to 70% and similar to 86% of the watersheds, respectively. For the remaining watersheds, the proximal spatial pattern was similar to 12x and similar to 4x greater than the distal spatial pattern for the >= 5% and >= 15% impervious cover thresholds, respectively. The proximal spatial pattern of impervious cover occurred predominantly in non-urbanized watersheds, resulting in a widespread occurrence of a relatively high percentage of streams flowing through relatively high impervious cover in watersheds where the total percentage impervious cover was relatively low. The spatial pattern of change in impervious cover between ca. 2001 and ca. 2006 did not avoid streams. Impervious cover increased in the vicinity streams in similar to 55% of the watersheds with increases in impervious cover. During this period, the length of streams flowing through >= 5% and >= 15% impervious cover increased by similar to 9800 km and similar to 6900 km, respectively. Published by Elsevier Ltd. C1 [Wickham, J. D.; Wade, T. G.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Norton, D. J.] US EPA, Off Water, Washington, DC 20460 USA. RP Wickham, JD (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Environm Sci Div, Mail Drop E243-05, Res Triangle Pk, NC 27711 USA. EM wickham.james@epa.gov FU United States Environmental Protection Agency, through its Office of Research and Development FX The United States Environmental Protection Agency, through its Office of Research and Development, funded and managed the research described here. The article has been reviewed by the USEPA's Office of Research and Development and approved for publication. Approval does not signify that the contents reflect the views of the USEPA. The authors are grateful for comments on earlier drafts by Taylor Jarnagin (USEPA) and two anonymous reviewers. Use of trade names does not imply endorsement by the U.S. Government. NR 30 TC 2 Z9 2 U1 7 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD MAY PY 2014 VL 40 BP 109 EP 116 DI 10.1016/j.ecolind.2014.01.013 PG 8 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AD8DA UT WOS:000333495500013 ER PT J AU Hoque, YM Hantush, MM Govindaraju, RS AF Hoque, Yamen M. Hantush, Mohamed M. Govindaraju, Rao S. TI On the scaling behavior of reliability-resilience-vulnerability indices in agricultural watersheds SO ECOLOGICAL INDICATORS LA English DT Article DE Risk indices; Reliability; Resilience; Vulnerability; Watershed; Water quality; Spatial scale; Best management practices ID RIVER NETWORKS; HYDROLOGIC ALTERATION; CHANNEL NETWORKS; MACROINVERTEBRATE COMMUNITIES; MANAGEMENT-PRACTICES; OUTPUT UNCERTAINTY; QUALITY ASSESSMENT; SPATIAL SCALES; SWAT MODEL; STREAM AB Risk indices such as reliability-resilience-vulnerability (R-R-V) have been proposed to assess watershed health. In this study, the spatial scaling behavior of R-R-V indices has been explored for five agricultural watersheds in the midwestern United States. The study was conducted using two different measures of spatial scale: (i) the ratio of contributing upland area to area required for channel initiation (FA), and (ii) Strahler stream order. It was found that R-R-V indices do change with spatial scale, but a representative watershed-specific threshold FA value exists for these indices to achieve stable values. Scaling with Strahler stream order is feasible if the watershed possesses a tree-like stream network. As an example of anthropogenic influences, this study also examined the role of BMPs placed within an agricultural watershed via a cost-effective optimization scheme on the evolution of R-R-V values with scale. While the placement of BMPs achieved reductions in concentrations and/or loads of constituents, they may not significantly change watershed risk measures, but are likely to cause significant reduction in vulnerability. If primarily upland BMPs are placed in a diffuse manner throughout the watershed, there might not be a significant change in the scaling behavior of R-R-V values. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Hoque, Yamen M.; Govindaraju, Rao S.] Purdue Univ, Dept Civil Engn, W Lafayette, IN 47907 USA. [Hantush, Mohamed M.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Hoque, YM (reprint author), Purdue Univ, Dept Civil Engn, W Lafayette, IN 47907 USA. EM yhoque@purdue.edu FU U.S. Environmental Protection Agency through its Office of Research and Development under EPA [EP-C-11-006] FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under EPA Contract # EP-C-11-006. It has not been subjected to Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. NR 80 TC 6 Z9 6 U1 8 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD MAY PY 2014 VL 40 BP 136 EP 146 DI 10.1016/j.ecolind.2014.01.017 PG 11 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AD8DA UT WOS:000333495500016 ER PT J AU Whelan, G Kim, K Pelton, MA Castleton, KJ Laniak, GF Wolfe, K Parmar, R Babendreier, J Galvin, M AF Whelan, Gene Kim, Keewook Pelton, Mitch A. Castleton, Karl J. Laniak, Gerard F. Wolfe, Kurt Parmar, Rajbir Babendreier, Justin Galvin, Michael TI Design of a component-based integrated environmental modeling framework SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Integrated environmental modeling; Multimedia modeling; IEM; Risk assessment; FRAMES ID RISK-ASSESSMENT MODELS; MULTIMEDIA BENCHMARKING ANALYSIS; EARTH SYSTEM; ECOSYSTEM SERVICES; CONTAMINANT PLUME; MEPAS; MMSOILS; RESRAD; UNCERTAINTY; MANAGEMENT AB Integrated environmental modeling (IEM) includes interdependent science-based components that comprise an appropriate software modeling system and are responsible for consuming and producing information as part of the system, but moving information from one component to another (i.e., interoperability) is the responsibility of the IEM software system. We describe and discuss the Framework for Risk Analysis in Multimedia Environmental Systems (FRAMES), a component-based IEM system, from the standpoint of software design requirements which define system functionalities. Design requirements were identified in a series of workshops, attended by IEM practitioners, and reported in the development of a number of IEM software systems. The requirements cover issues associated with standards, component connectivity, linkage protocols, system architecture and functionality, and web-based access, all of which facilitate the creation of plug & play components from stand-alone models through a series of software support tools and standards. Published by Elsevier Ltd. C1 [Whelan, Gene; Kim, Keewook; Laniak, Gerard F.; Wolfe, Kurt; Parmar, Rajbir; Babendreier, Justin; Galvin, Michael] US EPA, Off Res & Dev, Athens, GA 30605 USA. [Kim, Keewook] US DOE, Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Pelton, Mitch A.; Castleton, Karl J.] Pacific NW Natl Lab, Richland, WA 99352 USA. RP Whelan, G (reprint author), US EPA, Off Res & Dev, Athens, GA 30605 USA. EM Whelan.Gene@epa.gov OI Kim, Keewook/0000-0002-6625-7285 FU DOE [DW8992298301]; EPA [DW8992298301] FX The United States Environmental Protection Agency (EPA) through its Office of Research and Development collaborated in the research described here with EPA's Office of Radiation and Indoor Air, the U.S. Department of Energy's (DOE's) Pacific Northwest National Laboratory, U.S. Nuclear Regulatory Commission, and U.S. Army Corps of Engineers Engineer Research and Development Center. The authors would also like to thank Drs. Andrew Hughes, The British Geological Survey, and Scott Peckham, University of Colorado, for useful discussions on IEM software requirements. Although this document has been reviewed in accordance with EPA policy and approved for publication, it may not necessarily reflect official Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This research was supported in part by an appointment to the Postdoctoral Research Program at the Ecosystems Research Division administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. (DW8992298301) between DOE and EPA. NR 192 TC 10 Z9 10 U1 1 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD MAY PY 2014 VL 55 BP 1 EP 24 DI 10.1016/j.envsoft.2014.01.016 PG 24 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA AE5BW UT WOS:000334003800001 ER PT J AU Whelan, G Kim, K Pelton, MA Soller, JA Castleton, KJ Molina, M Pachepsky, Y Zepp, R AF Whelan, Gene Kim, Keewook Pelton, Mitch A. Soller, Jeffrey A. Castleton, Karl J. Molina, Marirosa Pachepsky, Yakov Zepp, Richard TI An integrated environmental modeling framework for performing Quantitative Microbial Risk Assessments SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Integrated environmental modeling; QMRA; Risk assessment; Pathogens; Manure; Watershed modeling ID MULTIMEDIA BENCHMARKING ANALYSIS; SATURATED POROUS-MEDIA; ESCHERICHIA-COLI; DAIRY HERDS; REPRODUCIBLE RESEARCH; RECREATIONAL WATERS; SIMULATED RAINFALL; FECAL-COLIFORMS; MARINE WATER; TRANSPORT AB Standardized methods are often used to assess the likelihood of a human-health effect from exposure to a specified hazard, and inform opinions and decisions about risk management and communication. A Quantitative Microbial Risk Assessment (QMRA) is specifically adapted to detail potential human-health risks from exposure to pathogens; it can include fate and transport models for various media, including the source zone (initial fecal release), air, soil/land surface, surface water, vadose zone and aquifer. The analysis step of a QMRA can be expressed as a system of computer-based data delivery and modeling that integrates interdisciplinary, multiple media, exposure and effects models and databases. Although QMRA does not preclude using source-term and fate and transport models, it is applied most commonly where the source-term is represented by the receptor location (i.e., exposure point), so the full extent of exposure scenarios has not been rigorously modeled. An integrated environmental modeling infrastructure is, therefore, ideally suited to include fate and transport considerations and link the risk assessment paradigm between source and receptor seamlessly. A primary benefit of the source-to-outcome approach is that it allows an expanded view of relevant cause-and-effect relationships, which facilitate consideration of management options related to source terms and their fate and transport pathways. The Framework for Risk Analysis in Multimedia Environmental Systems (FRAMES) provides software technology for analysts to insert appropriate models and databases that fit the problem statement and design and construct QMRAs that are reproducible, flexible, transferable, reusable, and transparent. A sample application using different models and databases registered with FRAMES is presented. It illustrates how models are linked to assess six different manure-based contaminant sources, following three pathogens (Salmonella eterica, Cryptosporidium spp., and Escherichia coli O157:H7) to a receptor where exposures and health risk impacts are then evaluated. The modeling infrastructure demonstrates how analysts could use the system to discern which pathogens might be important and when, and which sources could contribute to their importance. Published by Elsevier Ltd. C1 [Whelan, Gene; Kim, Keewook; Molina, Marirosa; Zepp, Richard] US EPA, Off Res & Dev, Athens, GA 30605 USA. [Kim, Keewook] US DOE, Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Pelton, Mitch A.; Castleton, Karl J.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Soller, Jeffrey A.] Soller Environm LLC, Berkeley, CA USA. [Pachepsky, Yakov] ARS, USDA, Beltsville, MD USA. RP Whelan, G (reprint author), US EPA, Off Res & Dev, Athens, GA 30605 USA. EM Whelan.Gene@epa.gov OI Kim, Keewook/0000-0002-6625-7285; Pachepsky, Yakov/0000-0003-0232-6090 FU U.S. Department of Energy; EPA FX The United States Environmental Protection Agency (EPA) through its Office of Research and Development collaborated with John Ravenscroft of the EPA Office of Water. It has been subjected to Agency review and approved for publication. This research was supported in part by an appointment to the Research Participation Program at the EPA Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 161 TC 6 Z9 6 U1 3 U2 40 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD MAY PY 2014 VL 55 BP 77 EP 91 DI 10.1016/j.envsoft.2013.12.013 PG 15 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA AE5BW UT WOS:000334003800007 ER PT J AU Tufts, JAM Calfee, MW Lee, SD Ryan, SP AF Tufts, Jenia A. M. Calfee, M. Worth Lee, Sang Don Ryan, Shawn P. TI Bacillus thuringiensis as a surrogate for Bacillus anthracis in aerosol research SO WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY LA English DT Review DE Anthrax; Biological outdoor decontamination; Detection ID SURFACE HYDROPHOBICITY; STRUCTURAL DYNAMICS; STAINLESS-STEEL; CEREUS SPORES; EXOSPORIUM; PROTEIN; ARCHITECTURE; MORPHOLOGY; ADHESION; STRAINS AB Characterization of candidate surrogate spores prior to experimental use is critical to confirm that the surrogate characteristics are as closely similar as possible to those of the pathogenic agent of interest. This review compares the physical properties inherent to spores of Bacillus anthracis (Ba) and Bacillus thuringiensis (Bt) that impact their movement in air and interaction with surfaces, including size, shape, density, surface morphology, structure and hydrophobicity. Also evaluated is the impact of irradiation on the physical properties of both Bacillus species. Many physical features of Bt and Ba have been found to be similar and, while Bt is considered typically non-pathogenic, it is in the B. cereus group, as is Ba. When cultured and sporulated under similar conditions, both microorganisms share a similar cylindrical pellet shape, an aerodynamic diameter of approximately 1 mu m (in the respirable size range), have an exosporium with a hairy nap, and have higher relative hydrophobicities than other Bacillus species. While spore size, morphology, and other physical properties can vary among strains of the same species, the variations can be due to growth/sporulation conditions and may, therefore, be controlled. Growth and sporulation conditions are likely among the most important factors that influence the representativeness of one species, or preparation, to another. All Bt spores may, therefore, not be representative of all Ba spores. Irradiated spores do not appear to be a good surrogate to predict the behavior of non-irradiated spores due to structural damage caused by the irradiation. While the use of Bt as a surrogate for Ba in aerosol testing appears to be well supported, this review does not attempt to narrow selection between Bt strains. Comparative studies should be performed to test the hypothesis that viable Ba and Bt spores will behave similarly when suspended in the air (as an aerosol) and to compare the known microscale characteristics versus the macroscale response. C1 [Tufts, Jenia A. M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Tufts, Jenia A. M.; Calfee, M. Worth; Lee, Sang Don; Ryan, Shawn P.] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Calfee, MW (reprint author), US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM calfee.worth@epa.gov FU National Homeland Security Research Center, U.S. Environmental Protection Agency FX This project was supported in part by an appointment to the Research Participation Program at the National Homeland Security Research Center, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. Additionally, the authors would like to thank Gene Rice (U.S. Environmental Protection Agency, Cincinnati, Ohio), Vipin Rastogi (US Army - ECBC, APG, MD) and Timothy Dean (U.S. Environmental Protection Agency, Research Triangle Park, NC) for their critical review of this manuscript. NR 62 TC 7 Z9 7 U1 0 U2 22 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0959-3993 EI 1573-0972 J9 WORLD J MICROB BIOT JI World J. Microbiol. Biotechnol. PD MAY PY 2014 VL 30 IS 5 BP 1453 EP 1461 DI 10.1007/s11274-013-1576-x PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AD9YM UT WOS:000333620600002 PM 24338558 ER PT J AU Price, K Purucker, ST Kraemer, SR Babendreier, JE Knightes, CD AF Price, Katie Purucker, S. Thomas Kraemer, Stephen R. Babendreier, Justin E. Knightes, Chris D. TI Comparison of radar and gauge precipitation data in watershed models across varying spatial and temporal scales SO HYDROLOGICAL PROCESSES LA English DT Article DE spatiotemporal; Stage IV NEXRAD; scale; SWAT; MPE ID RAIN-GAUGE; UNITED-STATES; RIVER-BASIN; STREAMFLOW SIMULATION; PARAMETER UNCERTAINTY; SAMPLING ERRORS; REGIONAL-SCALE; RUNOFF MODELS; FLOOD EVENTS; SWAT MODEL AB Precipitation is a key control on watershed hydrologic modelling output, with errors in rainfall propagating through subsequent stages of water quantity and quality analysis. Most watershed models incorporate precipitation data from rain gauges; higher-resolution data sources are available, but they are associated with greater computational requirements and expertise. Here, we investigate whether the Multisensor Precipitation Estimator (MPE or Stage IV Next-Generation Radar) data improve the accuracy of streamflow simulations using the Soil and Water Assessment Tool (SWAT), compared with rain gauge data. Simulated flows from 2002 to 2010 at five timesteps were compared with observed flows for four nested subwatersheds of the Neuse River basin in North Carolina (21-, 203-, 2979-, and 10 100-km(2) watershed area), using a multi-objective function, informal likelihood-weighted calibration approach. Across watersheds and timesteps, total gauge precipitation was greater than radar precipitation, but radar data showed a conditional bias of higher rainfall estimates during large events (>25-50 mm/day). Model parameterization differed between calibrations with the two datasets, despite the fact that all watershed characteristics were the same across simulation scenarios. This underscores the importance of linking calibration parameters to realistic processes. SWAT simulations with both datasets underestimated median and low flows, whereas radar-based simulations were more accurate than gauge-based simulations for high flows. At coarser timesteps, differences were less pronounced. Our results suggest that modelling efforts in watersheds with poor rain gauge coverage can be improved with MPE radar data, especially at short timesteps. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. C1 [Price, Katie; Purucker, S. Thomas; Kraemer, Stephen R.; Babendreier, Justin E.; Knightes, Chris D.] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, Athens, GA 30605 USA. RP Price, K (reprint author), US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, 960 Coll Stn Rd, Athens, GA 30605 USA. EM price.katie.m@gmail.com NR 96 TC 14 Z9 14 U1 2 U2 32 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD APR 30 PY 2014 VL 28 IS 9 BP 3505 EP 3520 DI 10.1002/hyp.9890 PG 16 WC Water Resources SC Water Resources GA AE2XC UT WOS:000333835600011 ER PT J AU Podhorniak, LV AF Podhorniak, Lynda V. TI A Rapid Miniaturized Residue Analytical Method for the Determination of Zoxamide and Its Two Acid Metabolites in Ginseng Roots Using UPLC-MS/MS SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE ginseng; Panax; zoxamide; UPLC-MS/MS; acid metabolite; ethyl acetate; alkaline buffer ID MASS-SPECTROMETRY AB A miniaturized residue method was developed for the analysis of the fungicide zoxamide and its metabolites in dried ginseng root. The zoxamide metabolites, 3,5-dichloro-1,4-benzenedicarboxylic acid (DCBC) and 3,5-dichloro-4-hydroxymethylbenzoic acid (DCHB), are small acid molecules that have not been previously extracted from the ginseng matrix with common multiresidue methods. The presented extraction method effectively and rapidly recovers both the zoxamide parent compound and its acid metabolites from fortified ginseng root. The metabolites are extracted with an alkaline glycine buffer and the aqueous ginseng mixture is partitioned with ethyl acetate. In addition, this method avoids the use of derivatization of the small acid molecules by using UPLC-MS/MS instrumental analysis. In a quantitative validation of the analytical method at three levels for zoxamide (0.007 (LOD), 0.02 (LOQ), and 0.2 mg/kg) and four levels (0.07 (LOD), 0.2 (LOQ), and 0.6 and 6 mg/kg) for both metabolites, acceptable method performances were achieved with recoveries ranging from 86 to 107% (at levels of LOQ and 3X, 10X, and 30x the LOQ) with <20% RSD for the three analytes in accordance with international guidelines.(1) C1 US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, Ft George G Meade, MD 20755 USA. RP Podhorniak, LV (reprint author), US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. EM Podhorniak.Lynda@epa.gov NR 12 TC 1 Z9 1 U1 1 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD APR 30 PY 2014 VL 62 IS 17 BP 3702 EP 3709 DI 10.1021/jf405403v PG 8 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA AG4DI UT WOS:000335369100008 PM 24552297 ER PT J AU Paulot, F Jacob, DJ Pinder, RW Bash, JO Travis, K Henze, DK AF Paulot, F. Jacob, D. J. Pinder, R. W. Bash, J. O. Travis, K. Henze, D. K. TI Ammonia emissions in the United States, European Union, and China derived by high-resolution inversion of ammonium wet deposition data: Interpretation with a new agricultural emissions inventory (MASAGE_NH3) SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID BOUND-CONSTRAINED OPTIMIZATION; PARTICULATE AIR-POLLUTION; NITROGEN DEPOSITION; GEOS-CHEM; ATMOSPHERIC AMMONIA; REACTIVE NITROGEN; ADJOINT MODEL; DAIRY-COWS; QUALITY; SCALE C1 [Paulot, F.; Jacob, D. J.; Travis, K.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Pinder, R. W.; Bash, J. O.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Henze, D. K.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. RP Paulot, F (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. EM paulot@seas.harvard.edu RI Chem, GEOS/C-5595-2014; Travis, Katherine/G-1417-2016; OI Travis, Katherine/0000-0003-1628-0353; Bash, Jesse/0000-0001-8736-0102 FU NASA Applied Science Program as part of the Air Quality Applied Science Team (AQAST); Harvard University Center; NASA ACMAP [NNX10AG63G]; EPA-STAR [RD83455901] FX F.P. thanks Rynda Hudman Kay (EPA) for providing the MODIS green-up and brown-down data set and Giulia Conchedda (FAO) for assistance with the FAO-gridded livestock of the world product. F. P. thanks Paul O. Wennberg for the use of the HP cluster of the Caltech Division of Geology and Planetary Sciences. This work was supported by the NASA Applied Science Program as part of the Air Quality Applied Science Team (AQAST). F. P. was supported by a Harvard University Center for the Environment fellowship. D. K. H. recognizes support from NASA ACMAP NNX10AG63G and EPA-STAR RD83455901. We acknowledge the E-OBS dataset from the EU-FP6 project ENSEMBLES (http://ensembles-eu.metoffice.com) and the data providers in the ECA&D project (http://www.ecad.eu). The ACCMIP inventory was down-loaded from the ECCAD-Ether portal. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official agency policy. NR 108 TC 45 Z9 46 U1 16 U2 84 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD APR 16 PY 2014 VL 119 IS 7 BP 4343 EP 4364 DI 10.1002/2013JD021130 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AF7PZ UT WOS:000334908300040 ER PT J AU Neil, CW Yang, YJ Schupp, D Jun, YS AF Neil, Chelsea W. Yang, Y. Jeffrey Schupp, Don Jun, Young-Shin TI Water Chemistry Impacts on Arsenic Mobilization from Arsenopyrite Dissolution and Secondary Mineral Precipitation: Implications for Managed Aquifer Recharge SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MUNICIPAL WASTE-WATER; GROUNDWATER RESOURCES; NITRATE REDUCTION; TERTIARY EFFLUENT; DRINKING-WATER; WEST-BENGAL; IRON-OXIDES; RECOVERY; STORAGE; SYSTEM AB Managed aquifer recharge (MAR) is a water reuse technique with the potential to meet growing water demands. However, MAR sites have encountered arsenic mobilization resulting from recharge operations. To combat this challenge, it is imperative to identify the mechanisms of arsenic mobilization during MAR. In this bench-scale study, arsenic mobilization from arsenopyrite (FeAsS) was characterized for conditions relevant to MAR operations. Experimentally determined activation energies for arsenic mobilization from FeAsS under aerobic conditions were 36.9 +/- 2.3 kJ/mol for 10 mM sodium chloride, 40.8 +/- 3.5 kJ/mol for 10 mM sodium nitrate, and 43.6 +/- 5.0 kJ/mol for secondary effluent from a wastewater treatment plant. Interestingly, the sodium chloride system showed higher arsenic mobilization under aerobic conditions. In addition, secondary mineral precipitation varied among systems and further affected arsenic mobilization. For example, the wastewater system inhibited precipitation, while in the sodium chloride system, faster phase transformation of iron(III) (hydr)oxide precipitates was observed, resulting in hematite formation after 7 days. The phase transformation to hematite will result in less available surface area for arsenic attenuation. These new observations and activation energies can be useful to develop improved reactive transport models for the fate of arsenic during MAR, and develop strategies to minimize arsenic release. C1 [Neil, Chelsea W.; Jun, Young-Shin] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Schupp, Don] CB&I, Cincinnati, OH 45212 USA. RP Jun, YS (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. EM ysjun@seas.wustl.edu FU Washington University's Faculty Startup; Mr. and Mrs. Spencer T. Olin Fellowship; EPA Water Resources Adaptation Program (WRAP) [EP-C-09-041] FX We are grateful for support received from Washington University's Faculty Startup. We thank the Environmental NanoChemistry Group members for valuable discussion. C.W.N. acknowledges the generous support of the Mr. and Mrs. Spencer T. Olin Fellowship. This study was partially supported by the EPA Water Resources Adaptation Program (WRAP) research conducted with partial sponsorship under EPA Contract EP-C-09-041. The research described herein has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. NR 65 TC 12 Z9 12 U1 9 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2014 VL 48 IS 8 BP 4395 EP 4405 DI 10.1021/es405119q PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AF4CG UT WOS:000334658400020 PM 24621369 ER PT J AU He, XX Zhang, GS de la Cruz, AA O'Shea, KE Dionysiou, DD AF He, Xuexiang Zhang, Geshan de la Cruz, Armah A. O'Shea, Kevin E. Dionysiou, Dionysios D. TI Degradation Mechanism of Cyanobacterial Toxin Cylindrospermopsin by Hydroxyl Radicals in Homogeneous UV/H2O2 Process SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID OXIDATION; MICROCYSTINS; CYANOTOXIN; TOXICITY AB The degradation of cylindrospermopsin (CYN), a widely distributed and highly toxic cyanobacterial toxin (cyanotoxin), remains poorly elucidated. In this study, the mechanism of CYN destruction by UV-254 nm/H2O2 advanced oxidation process (AOP) was investigated by mass spectrometry. Various byproducts identified indicated three common reaction pathways: hydroxyl addition (+16 Da), alcoholic oxidation or dehydrogenation (-2 Da), and elimination of sulfate (-80 Da). The initiation of the degradation was observed at the hydroxymethyl uracil and tricyclic guanidine groups; uracil moiety cleavage/fragmentation and further ring-opening of the alkaloid were also noted at an extended reaction time or higher UV fluence. The degradation rates of CYN decreased and less byproducts (species) were detected using natural water matrices; however, CYN was effectively eliminated under extended UV irradiation. This study demonstrates the efficiency of CYN degradation and provides a better understanding of the mechanism of CYN degradation by hydroxyl radical, a reactive oxygen species that can be generated by most AOPs and is present in natural water environment. C1 [He, Xuexiang; Zhang, Geshan; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [O'Shea, Kevin E.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [He, Xuexiang; Dionysiou, Dionysios D.] Univ Cyprus, NIREAS Int Water Res Ctr, CY-1678 Nicosia, Cyprus. RP Dionysiou, DD (reprint author), Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. EM dionysios.d.dionysiou@uc.edu RI He, Xuexiang/D-7564-2017 FU Cyprus Research Promotion Foundation through Desmi; Republic of Cyprus [NEA IPODOMI/STRATH/0308/09]; European Regional Development Fund of the EU [NEA IPODOMI/STRATH/0308/09]; University Research Council of University of Cincinnati; Graduate School of UC FX This work was funded by the Cyprus Research Promotion Foundation through Desmi 2009-2010 which is cofunded by the Republic of Cyprus and the European Regional Development Fund of the EU under contract number NEA IPODOMI/STRATH/0308/09. X.H. is grateful for the University Research Council of University of Cincinnati for a Summer Research Fellowship and Graduate School of UC for a Dissertation Completion Fellowship. We are thankful to Greater Cincinnati Water Works, especially Maria Meyer, for providing water samples. Disclaimer: The views expressed in this manuscript do not reflect the views and policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement. NR 12 TC 15 Z9 15 U1 10 U2 90 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2014 VL 48 IS 8 BP 4495 EP 4504 DI 10.1021/es403732s PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AF4CG UT WOS:000334658400031 PM 24625255 ER PT J AU Bejarano, AC Barron, MG AF Bejarano, Adriana C. Barron, Mace G. TI Development and Practical Application of Petroleum and Dispersant Interspecies Correlation Models for Aquatic Species SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID EARLY-LIFE STAGES; SENSITIVITY DISTRIBUTIONS; CRUDE-OIL; COMPARATIVE TOXICITY; WATER; WILDLIFE; CRITERIA AB Assessing the acute toxicity of oil has generally relied on existing toxicological data for a relatively few standard test species, which has limited the ability to estimate the impacts of spilled oil on aquatic communities. Interspecies correlation estimation (ICE) models were developed for petroleum and dispersant products to facilitate the prediction of toxicity values to a broader range of species and to better understand taxonomic differences in species sensitivity. ICE models are log linear regressions that can be used to estimate toxicity to a diversity of taxa based on the known toxicity value for a surrogate tested species. ICE models have only previously been developed for nonpetroleum chemicals. Petroleum and dispersant ICE models were statistically significant for 93 and 16 unique surrogate-predicted species pairs, respectively. These models had adjusted coefficient of determinations (adj-R-2), square errors (MSE) and positive slope ranging from 0.29 to 0.99, 0.0002 to 0.311, and 0.187 to 2.665, respectively. Based on model cross-validation, predicted values for most ICE models (>90%) were within 5-fold of the measured values, with no influence of taxonomic relatedness on prediction accuracy. A comparison between hazard concentrations (HC) derived from empirical and ICE-based species sensitivity distributions (SSDs) showed that HC values were within the same order of magnitude of each other. These results show that ICE-based SSDs provide a statistically valid approach to estimating toxicity to a range of petroleum and dispersant products with applicability to oil spill assessment. toxicity C1 [Bejarano, Adriana C.] Res Planning Inc, Columbia, SC 29201 USA. [Barron, Mace G.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Bejarano, AC (reprint author), Res Planning Inc, 1121 Pk St, Columbia, SC 29201 USA. EM abejarano@researchplanning.com FU NOAA; University of New Hampshire's Coastal Response Research Center [13-034] FX Special thanks to C. Jackson and S. Raimondo (U.S. EPA) for comments to an earlier version of this manuscript. This research was made possible by a grant from NOAA and the University of New Hampshire's Coastal Response Research Center (Contract No. 13-034) to Research Planning, Inc. None of these results have been reviewed by CRRC and no endorsement should be inferred. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA. This publication does not constitute an endorsement of any commercial product. NR 46 TC 7 Z9 7 U1 2 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2014 VL 48 IS 8 BP 4564 EP 4572 DI 10.1021/es500649v PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AF4CG UT WOS:000334658400039 PM 24678991 ER PT J AU King, K Ogle, C AF King, Katherine Ogle, Christin TI Negative Life Events Vary by Neighborhood and Mediate the Relation between Neighborhood Context and Psychological Well-Being SO PLOS ONE LA English DT Article ID PHYSICAL HEALTH; OLDER-ADULTS; COLLECTIVE EFFICACY; SOCIAL DISPARITIES; DISORDER; STRESS; TRAUMA; ENVIRONMENT; EPIDEMIOLOGY; SEGREGATION AB Researchers have speculated that negative life events are more common in troubled neighborhoods, amplifying adverse effects on health. Using a clustered representative sample of Chicago residents (2001-03; n = 3,105) from the Chicago Community Adult Health Survey, we provide the first documentation that negative life events are highly geographically clustered compared to health outcomes. Associations between neighborhood context and negative life events were also found to vary by event type. We then demonstrate the power of a contextualized approach by testing path models in which life events mediate the relation between neighborhood characteristics and health outcomes, including self-rated health, anxiety, and depression. The indirect paths between neighborhood conditions and health through negative life event exposure are highly significant and large compared to the direct paths from neighborhood conditions to health. Our results indicate that neighborhood conditions can have acute as well as chronic effects on health, and that negative life events are a powerful mechanism by which context may influence health. C1 [King, Katherine] US EPA, Environm Publ Hlth Div, Chapel Hill, NC USA. [King, Katherine] Duke Univ, Durham, NC USA. [Ogle, Christin] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA. RP King, K (reprint author), US EPA, Environm Publ Hlth Div, Chapel Hill, NC USA. EM keking@umich.edu FU Duke University Medical Center (King, Ogle); U.S. Environmental Protection Agency; Office of Research and Development; Oak Ridge Institute for Science and Education; [2T32 AG000029-35] FX This work was supported in part by grant 2T32 AG000029-35 to the Center for the Study of Aging and Human Development, Duke University Medical Center (King, Ogle) and in part by an appointment (King) to the Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and EPA. This work does not represent the official policies of the Environmental Protection Agency. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 66 TC 10 Z9 10 U1 2 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 8 PY 2014 VL 9 IS 4 AR e93539 DI 10.1371/journal.pone.0093539 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AE7FA UT WOS:000334160900032 PM 24714115 ER PT J AU Lu, SY Wang, QL Stevens, WR Lee, CW Gullett, BK Zhao, YX AF Lu, Sheng-yong Wang, Qiu-lin Stevens, William R. Lee, Chun Wai Gullett, Brian K. Zhao, Yong-xin TI Study on the decomposition of trace benzene over V2O5-WO3/TiO2-based catalysts in simulated flue gas SO APPLIED CATALYSIS B-ENVIRONMENTAL LA English DT Article DE Honeycombed catalyst; REMPI-TOFMS; Trace benzene; Simulated flue gas; Raman spectroscopy ID VANADIUM-OXIDE CATALYSTS; TEMPERATURE-PROGRAMMED REDUCTION; ALTERNATIVE SCR CATALYSTS; IN-SITU IR; METHANOL OXIDATION; HETEROGENEOUS CATALYSIS; RAMAN-SPECTROSCOPY; METAL-OXIDES; DESTRUCTION; ABATEMENT AB Catalytic decomposition of benzene was studied by using oxides of vanadium and tungsten supported on titanium oxide (TiO2) catalysts for effective reduction of emissions of toxic organic compounds from waste incineration. Experiments were conducted to evaluate the effects of the catalyst's composition, and operating conditions on benzene decomposition, and the relationship between molecular structures of catalysts and their activity was also investigated through replacing the conventional TiO2 catalyst support by nano-sized TiO2. Trace levels (1 and 10 ppm) of gaseous benzene were catalytically decomposed in a fixed-bed catalytic reactor with monolithic oxides of vanadium and tungsten supported on titanium oxide (V2O5-WO3/TiO2) catalysts under conditions simulating the cooling of waste incineration flue gas. On-line monitoring of trace benzene concentrations before and after the catalyst was achieved by means of resonance enhanced multiphoton ionization-time of flight mass spectrometry (REMPI-TOFMS). Catalysts were characterized by nitrogen adsorption, X-ray diffraction, energy dispersive X-ray spectroscopy, temperature-programmed reduction, and Raman spectroscopy. The effects of several parameters, including catalyst operating temperature, space velocity (SV) and initial benzene concentration, on catalytic oxidation of benzene were investigated. Experimental results indicate that reduction of the initial benzene concentration from 10 to 1 ppm either enhances or decreases the catalytic removal efficiency depending on the adsorption capability as well as the oxidation ability of the catalyst tested. The catalytic activity for benzene oxidation not simply relies on the vanadium content of the catalyst; the molecular structure of vanadium oxide, which is known to be influenced by both vanadium oxide loading and the type of support, is very important. Nano-sized TiO2 supported vanadium oxide catalyst (VWNT) with lowest V loading (0.75 wt.%) provides higher catalytic activity than those of the catalysts with higher V contents (1.31 and 2.92 wt.%) but supported by conventional TiO2 (VWT1 and VWT2). The relatively higher catalytic activity of VWNT may be attributed to: (a) the presence of monomeric VOx species, with one terminal V=O bond as indicated by Raman spectra; (b) fewer impurities confounding active catalytic constituents (V, W and Ti); (c) pure anatase phase of TiO2 rather than a mixture phase of anatase and rutile servicing as catalyst support besides its nano-scale particle size; (d) larger specific surface area, smaller average pore diameter, and narrower pore size distribution contribute higher adsorption ability for benzene. No obvious competition effect between NOx removal and benzene oxidation was observed in this study. Reaction rate constants and activation energies for benzene catalytic oxidation tested by the catalysts were calculated. Lower activation energy obtained from VWNT than those of the two catalysts further confirming the higher catalytic activity of VWNT. Published by Elsevier B.V. C1 [Lu, Sheng-yong; Wang, Qiu-lin] Zhejiang Univ, Inst Thermal Power Engn, State Key Lab Clean Energy Utilizat, Hangzhou 310027, Zhejiang, Peoples R China. [Lu, Sheng-yong; Stevens, William R.; Lee, Chun Wai; Gullett, Brian K.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Zhao, Yong-xin] ARCADIS US Inc, Durham, NC 27713 USA. RP Lee, CW (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM lee.chun-wai@epa.gov FU Major State Basic Research Development Program of China [2011CB201500]; National Natural Science Foundation of China [51276162]; Program of Introducing Talents of Discipline to University [B08026] FX The Project is supported by the Major State Basic Research Development Program of China (2011CB201500), the National Natural Science Foundation of China (51276162) and the Program of Introducing Talents of Discipline to University (B08026). Thanks for the experimental testing and data analysis support from the internship student, Mr. Jeremy Lecomte (Universite de Orleans, France, student intern at U.S. EPA). NR 54 TC 9 Z9 9 U1 5 U2 119 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-3373 EI 1873-3883 J9 APPL CATAL B-ENVIRON JI Appl. Catal. B-Environ. PD APR 5 PY 2014 VL 147 BP 322 EP 329 DI 10.1016/j.apcatb.2013.08.047 PG 8 WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical SC Chemistry; Engineering GA 300UL UT WOS:000330489400036 ER PT J AU Kaufmann, PR Hughes, RM Van Sickle, J Whittier, TR Seeliger, CW Paulsen, SG AF Kaufmann, Philip R. Hughes, Robert M. Van Sickle, John Whittier, Thomas R. Seeliger, Curt W. Paulsen, Steven G. TI Lakeshore and littoral physical habitat structure: A field survey method and its precision SO LAKE AND RESERVOIR MANAGEMENT LA English DT Article DE physical habitat; lake monitoring; lake habitat; lake disturbances; riparian disturbance; habitat complexity; field method precision; habitat structure ID PACIFIC-NORTHWEST; UNITED-STATES; STREAMS; FISH; ECOSYSTEMS; INDICATORS; MULTIPLE; EXTENT; US AB Measures of near-shore physical habitat structure have only recently been employed in large-scale assessments of lake ecological condition. We outline and evaluate a rapid approach for quantifying lake physical habitat structure and disturbance that was piloted in the Northeast United States by the US Environmental Protection Agency in its Environmental Monitoring and Assessment Program (EMAP-NE), then improved and applied in the 2007 National Lakes Assessment (NLA). This approach measures littoral habitat complexity, fish cover, substrate, aquatic macrophytes, riparian vegetation, and human disturbances. Of 46 NLA physical habitat metrics, 34 had repeat-visit standard deviations <10% of their potential ranges, indicating repeatability sufficient to distinguish 4 to 5 levels of habitat condition within that range. For 23 metrics, the signal to noise ratio (S/N) of among-lake to same-year repeat-visit variance was moderate to high (3-10), indicating that noise variance was a relatively small confounding factor in their interpretation. Most NLA metrics were 30-40% more precise than those of EMAP-NE, largely because NLA used a greater number of habitat percent cover classes. We conclude that the metrics and indices derived from the NLA physical habitat field approach are precise enough to quantify near-shore habitat structure for contributing to national, state, and ecoregional assessments of lake condition. C1 [Kaufmann, Philip R.; Paulsen, Steven G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Hughes, Robert M.] Amnis Opes Inst, Corvallis, OR 97333 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA. [Van Sickle, John] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA. [Whittier, Thomas R.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [Seeliger, Curt W.] Raytheon Informat Serv, Corvallis, OR 97333 USA. RP Kaufmann, PR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM kaufmann.phil@epa.gov FU US EPA Office of Research and Development, Environmental Monitoring and Assessment Program (EMAP); EPA Office of Water's National Lakes Assessment [CR-818606]; Oregon State University [68040019]; ManTech Corporation; Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [00011/09]; Companhia Energetica de Minas Gerais (CEMIG) FX Funding for data analysis and manuscript preparation were largely from the US EPA Office of Research and Development in support of the Environmental Monitoring and Assessment Program (EMAP) and the EPA Office of Water's National Lakes Assessment through cooperative agreement #CR-818606 with Oregon State University and contract #68040019 with ManTech Corporation. Bob Hughes was supported in manuscript preparation during sabbatical in Brazil by grant 00011/09 from Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), and Companhia Energetica de Minas Gerais (CEMIG). NR 47 TC 10 Z9 10 U1 1 U2 24 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1040-2381 EI 2151-5530 J9 LAKE RESERV MANAGE JI Lake Reserv. Manag. PD APR 3 PY 2014 VL 30 IS 2 BP 157 EP 176 DI 10.1080/10402381.2013.877543 PG 20 WC Limnology; Marine & Freshwater Biology; Water Resources SC Marine & Freshwater Biology; Water Resources GA AH1ED UT WOS:000335861700006 ER PT J AU Kaufmann, PR Hughes, RM Whittier, TR Bryce, SA Paulsen, SG AF Kaufmann, Philip R. Hughes, Robert M. Whittier, Thomas R. Bryce, Sandra A. Paulsen, Steven G. TI Relevance of lake physical habitat indices to fish and riparian birds SO LAKE AND RESERVOIR MANAGEMENT LA English DT Article DE lake monitoring; habitat complexity; riparian disturbance; lake habitat; physical habitat; lake disturbances; habitat structure; bird-habitat relationships; fish-habitat relationships ID CONTERMINOUS UNITED-STATES; NORTH-TEMPERATE LAKES; COARSE WOODY HABITAT; RESIDENTIAL DEVELOPMENT; PACIFIC-NORTHWEST; WISCONSIN LAKES; SPECIES-DIVERSITY; SEDIMENT CRITERIA; MOUNTAIN STREAMS; INTEGRITY INDEX AB Despite the historical focus on water quality, it is becoming increasingly evident that physical habitat conditions also significantly affect lake biota. We examined associations between fish and bird assemblages and lake physical habitat based on relatively rapid assessments of Northeast US lakes. Richness of intolerant fish species declined, and that of tolerant fish species increased across regional gradients of increasing shoreline human development and decreasing abundance and structural complexity of riparian vegetation and littoral cover. Breeding bird assemblages observed in the nearshore littoral and riparian area of these lakes were similarly affected by disturbance and habitat simplification. The percentage of native neotropical migrant birds declined, and the percent of tolerant bird species increased across the same gradients. We conclude that our relatively rapid physical habitat assessments produce biologically relevant metrics useful for evaluating lake physical habitat condition and potential impacts on lake biota in regional and national lake assessments. C1 [Kaufmann, Philip R.; Paulsen, Steven G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Hughes, Robert M.] Amnis Opes Inst, Corvallis, OR 97333 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA. [Whittier, Thomas R.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [Bryce, Sandra A.] Dynamac Corp, Corvallis, OR 97333 USA. RP Kaufmann, PR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM kaufmann.phil@epa.gov FU US EPA Office of Research and Development, Environmental Monitoring and Assessment Program (EMAP); EPA Office of Waters National Lakes Assessment [CR-818606]; Oregon State University [68040019]; ManTech Corporation; Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [00011/09]; Companhia Energetica deMinas Gerais (CEMIG) FX Funding for data analysis and manuscript preparation were largely from the US EPA Office of Research and Development in support of the Environmental Monitoring and Assessment Program (EMAP) and the EPA Office of Waters National Lakes Assessment through cooperative agreement #CR-818606 with Oregon State University and contract #68040019 with ManTech Corporation. Bob Hughes was supported in manuscript preparation during sabbatical in Brazil by grant 00011/09 from Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), and Companhia Energetica deMinas Gerais (CEMIG). NR 86 TC 11 Z9 12 U1 2 U2 33 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1040-2381 EI 2151-5530 J9 LAKE RESERV MANAGE JI Lake Reserv. Manag. PD APR 3 PY 2014 VL 30 IS 2 BP 177 EP 191 DI 10.1080/10402381.2013.877544 PG 15 WC Limnology; Marine & Freshwater Biology; Water Resources SC Marine & Freshwater Biology; Water Resources GA AH1ED UT WOS:000335861700007 ER PT J AU Kaufmann, PR Peck, DV Paulsen, SG Seeliger, CW Hughes, RM Whittier, TR Kamman, NC AF Kaufmann, Philip R. Peck, David V. Paulsen, Steven G. Seeliger, Curt W. Hughes, Robert M. Whittier, Thomas R. Kamman, Neil C. TI Lakeshore and littoral physical habitat structure in a national lakes assessment SO LAKE AND RESERVOIR MANAGEMENT LA English DT Article DE lake ecology; lake habitat; physical habitat structure; hydromorphology; reference condition; littoral habitat; riparian disturbance; monitoring; habitat complexity ID CONTERMINOUS UNITED-STATES; WATER BODY CHALLENGES; RESIDENTIAL DEVELOPMENT; REGIONAL-SCALE; SHORELINE DEVELOPMENT; PACIFIC-NORTHWEST; FISH ASSEMBLAGES; WISCONSIN LAKES; WOODY DEBRIS; FOOD-WEB AB Near-shore physical habitat is crucial for supporting biota and ecological processes in lakes. We used data from a statistical sample of 1101 lakes and reservoirs from the 2007 US Environmental Protection Agency National Lakes Assessment (NLA) to develop 4 indices of physical habitat condition: (1) Lakeshore Anthropogenic Disturbance, (2) Riparian Vegetation Cover Complexity, (3) Littoral Cover Complexity, and (4) Littoral-Riparian Habitat Complexity. We compared lake index values with distributions from least-disturbed lakes. Our results form the first US national assessment of lake physical habitat, inferring the condition (with known confidence) of the 49,500 lakes and reservoirs in the conterminous United States with surface areas >4 ha and depths >1m. Among the physical and chemical characteristics examined by the NLA, near-shore physical habitat was the most extensively altered relative to least-disturbed condition. Riparian Vegetation Cover Complexity was good in 46% (+/- 3%), fair in 18% (+/- 2%), and poor in 36% (+/- 2%) of lakes. Littoral-Riparian Habitat Complexity was good in 47% (+/- 3%), fair in 20% (+/- 2%), and poor in 32% (+/- 2%) of lakes. In every ecoregion, habitat condition was negatively related to anthropogenic pressures. Gradients of increased anthropogenic disturbance were accompanied by progressive simplification of littoral and riparian physical habitat. Nationwide, the proportion of lakes with degraded near-shore physical habitat was equal to or greater than that for excess nutrients and much greater than that for acidic conditions. In addition to better management of lake basins, we suggest an increased focus on protecting littoral and riparian physical habitat through better management of near-shore anthropogenic disturbance. C1 [Kaufmann, Philip R.; Peck, David V.; Paulsen, Steven G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Seeliger, Curt W.] US EPA, Raytheon Informat Serv, Corvallis, OR 97333 USA. [Hughes, Robert M.] Amnis Opes Inst, Corvallis, OR 97333 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA. [Whittier, Thomas R.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [Kamman, Neil C.] Vermont Dept Environm Conservat, Water Qual Div, Monitoring Assessment & Planning Program, Waterbury, VT 05671 USA. RP Kaufmann, PR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM kaufmann.phil@epa.gov FU USEPA Office of Research and Development, EPA Office of Water's National Lakes Assessment [CR-818606]; Oregon State University; Raytheon Information Services [GSFU594G]; Fulbright Brasil; Companhia Energetica de Minas Gerais (CEMIG); Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [00011/09] FX Funding for data analysis and manuscript preparation was largely from the USEPA Office of Research and Development in support of the EPA Office of Water's National Lakes Assessment through cooperative agreement #CR-818606 with Oregon State University and contract GSFU594G with Raytheon Information Services. Bob Hughes was supported in manuscript preparation during sabbatical in Brazil by Fulbright Brasil, Companhia Energetica de Minas Gerais (CEMIG), and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) grant 00011/09. NR 64 TC 14 Z9 16 U1 0 U2 32 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1040-2381 EI 2151-5530 J9 LAKE RESERV MANAGE JI Lake Reserv. Manag. PD APR 3 PY 2014 VL 30 IS 2 BP 192 EP 215 DI 10.1080/10402381.2014.906524 PG 24 WC Limnology; Marine & Freshwater Biology; Water Resources SC Marine & Freshwater Biology; Water Resources GA AH1ED UT WOS:000335861700008 ER PT J AU Schmieder, PK Kolanczyk, RC Hornung, MW Tapper, MA Denny, JS Sheedy, BR Aladjov, H AF Schmieder, P. K. Kolanczyk, R. C. Hornung, M. W. Tapper, M. A. Denny, J. S. Sheedy, B. R. Aladjov, H. TI A rule-based expert system for chemical prioritization using effects-based chemical categories SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article DE low affinity ER binding; industrial chemicals; expert system; chemical prioritization; effects-based chemical categories ID ESTROGEN-RECEPTOR BINDING; TROUT ONCORHYNCHUS-MYKISS; RECOMBINANT YEAST ASSAY; MECHANISTIC INTERPRETATION; ALKYLPHENOLS; INVENTORIES; PREDICTION; TOXICITY; PARABENS; LIGANDS AB A rule-based expert system (ES) was developed to predict chemical binding to the estrogen receptor (ER) patterned on the research approaches championed by Gilman Veith to whom this article and journal issue are dedicated. The ERES was built to be mechanistically transparent and meet the needs of a specific application, i.e. predict for all chemicals within two well-defined inventories (industrial chemicals used as pesticide inerts and antimicrobial pesticides). These chemicals all lack structural features associated with high affinity binders and thus any binding should be low affinity. Similar to the high-quality fathead minnow database upon which Veith QSARs were built, the ERES was derived from what has been termed gold standard data, systematically collected in assays optimized to detect even low affinity binding and maximizing confidence in the negatives determinations. The resultant logic-based decision tree ERES, determined to be a robust model, contains seven major nodes with multiple effects-based chemicals categories within each. Predicted results are presented in the context of empirical data within local chemical structural groups facilitating informed decision-making. Even using optimized detection assays, the ERES applied to two inventories of >600 chemicals resulted in only ~5% of the chemicals predicted to bind ER. C1 [Schmieder, P. K.; Kolanczyk, R. C.; Hornung, M. W.; Tapper, M. A.; Denny, J. S.; Sheedy, B. R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Aladjov, H.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. RP Schmieder, PK (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM schmieder.patricia@epa.gov OI Aladjov, Hristo/0000-0001-6227-3678 NR 38 TC 0 Z9 0 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1062-936X EI 1029-046X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PD APR 3 PY 2014 VL 25 IS 4 SI SI BP 253 EP 287 DI 10.1080/1062936X.2014.898691 PG 35 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA AG0EF UT WOS:000335087400002 PM 24779615 ER PT J AU Hornung, MW Tapper, MA Denny, JS Kolanczyk, RC Sheedy, BR Hartig, PC Aladjov, H Henry, TR Schmieder, PK AF Hornung, M. W. Tapper, M. A. Denny, J. S. Kolanczyk, R. C. Sheedy, B. R. Hartig, P. C. Aladjov, H. Henry, T. R. Schmieder, P. K. TI Effects-based chemical category approach for prioritization of low affinity estrogenic chemicals SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article DE chemical category; expert system; QSAR; estrogen; prioritization ID RELATIVE BINDING AFFINITIES; RECOMBINANT YEAST ASSAY; MEDAKA ORYZIAS-LATIPES; RAINBOW-TROUT; RECEPTOR-BINDING; ALKYLPHENOLIC CHEMICALS; LIGANDS; IDENTIFICATION; INVENTORIES; EXPRESSION AB Regulatory agencies are charged with addressing the endocrine disrupting potential of large numbers of chemicals for which there is often little or no data on which to make decisions. Prioritizing the chemicals of greatest concern for further screening for potential hazard to humans and wildlife is an initial step in the process. This paper presents the collection of in vitro data using assays optimized to detect low affinity estrogen receptor (ER) binding chemicals and the use of that data to build effects-based chemical categories following QSAR approaches and principles pioneered by Gilman Veith and colleagues for application to environmental regulatory challenges. Effects-based chemical categories were built using these QSAR principles focused on the types of chemicals in the specific regulatory domain of concern, i.e. non-steroidal industrial chemicals, and based upon a mechanistic hypothesis of how these non-steroidal chemicals of seemingly dissimilar structure to 17 ss-estradiol (E2) could interact with the ER via two distinct binding types. Chemicals were also tested to solubility thereby minimizing false negatives and providing confidence in determination of chemicals as inactive. The high-quality data collected in this manner were used to build an ER expert system for chemical prioritization described in a companion article in this journal. C1 [Hornung, M. W.; Tapper, M. A.; Denny, J. S.; Kolanczyk, R. C.; Sheedy, B. R.; Aladjov, H.; Henry, T. R.; Schmieder, P. K.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Hartig, P. C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. RP Hornung, MW (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM hornung.michael@epa.gov OI Aladjov, Hristo/0000-0001-6227-3678 NR 36 TC 3 Z9 3 U1 1 U2 11 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1062-936X EI 1029-046X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PD APR 3 PY 2014 VL 25 IS 4 SI SI BP 289 EP 323 DI 10.1080/1062936X.2014.898692 PG 35 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA AG0EF UT WOS:000335087400003 PM 24779616 ER PT J AU Aylward, LL Hays, SM Kirman, CR Marchitti, SA Kenneke, JF English, C Mattison, DR Becker, RA AF Aylward, L. L. Hays, S. M. Kirman, C. R. Marchitti, S. A. Kenneke, J. F. English, C. Mattison, D. R. Becker, R. A. TI Relationships of Chemical Concentrations in Maternal and Cord Blood: A Review of Available Data SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; POLYCYCLIC AROMATIC-HYDROCARBONS; BISPHENOL-A CONCENTRATIONS; PERFUSED HUMAN PLACENTA; DIBENZO-P-DIOXINS; UMBILICAL-CORD; POLYCHLORINATED-BIPHENYLS; PREGNANT-WOMEN; BREAST-MILK AB The developing fetus is likely to be exposed to the same environmental chemicals as the mother during critical periods of growth and development. The degree of maternal-fetal transfer of chemical compounds will be affected by chemical and physical properties such as lipophilicity, protein binding, and active transport mechanisms that influence absorption and distribution in maternal tissues. However, these transfer processes are not fully understood for most environmental chemicals. This review summarizes reported data from more than 100 studies on the ratios of cord:maternal blood concentrations for a range of chemicals including brominated flame-retardant compounds, polychlorinated biphenyls (PCB), polychlorinated dibenzodioxins and dibenzofurans, organochlorine pesticides, perfluorinated compounds, polyaromatic hydrocarbons, metals, and tobacco smoke components. The studies for the chemical classes represented suggest that chemicals frequently detected in maternal blood will also be detectable in cord blood. For most chemical classes, cord blood concentrations were found to be similar to or lower than those in maternal blood, with reported cord:maternal ratios generally between 0.1 and 1. Exceptions were observed for selected brominated flame-retardant compounds, polyaromatic hydrocarbons, and some metals, for which reported ratios were consistently greater than 1. Careful interpretation of the data in a risk assessment context is required because measured concentrations of environmental chemicals in cord blood (and thus the fetus) do not necessarily imply adverse effects or risk. Guidelines and recommendations for future cord:maternal blood biomonitoring studies are discussed. C1 [Aylward, L. L.] Summit Toxicol LLP, Falls Church, VA 22044 USA. [Aylward, L. L.] Univ Queensland, Natl Res Ctr Environm Toxicol, Brisbane, Qld, Australia. [Hays, S. M.] Summit Toxicol LLP, Allenspark, CO USA. [Kirman, C. R.] Summit Toxicol LLP, Orange Village, OH USA. [Marchitti, S. A.; Kenneke, J. F.] US EPA, Natl Exposure Res Lab, Athens, GA USA. [Mattison, D. R.] Univ Ottawa, Risk Sci Int, Ottawa, ON, Canada. [Mattison, D. R.] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada. [Becker, R. A.] Amer Chem Council, Washington, DC USA. RP Aylward, LL (reprint author), Summit Toxicol LLP, 6343 Carolyn Dr, Falls Church, VA 22044 USA. EM laylward@summittoxicology.com RI Aylward, Lesa/F-7418-2012; OI Aylward, Lesa/0000-0003-3191-8175; Mattison, Donald/0000-0001-5623-0874 FU American Chemistry Council FX Authors LLA, SMH, CRK, and CE received funding to support preparation of this review from the American Chemistry Council. The authors had complete freedom in the design, execution, analysis, and reporting of the review. NR 139 TC 15 Z9 15 U1 6 U2 50 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PD APR 3 PY 2014 VL 17 IS 3 BP 175 EP 203 DI 10.1080/10937404.2014.884956 PG 29 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AF4CW UT WOS:000334660000002 PM 24749481 ER PT J AU Hogrefe, C Roselle, S Mathur, R Rao, ST Galmarini, S AF Hogrefe, C. Roselle, S. Mathur, R. Rao, S. T. Galmarini, S. TI Space-time analysis of the Air Quality Model Evaluation International Initiative (AQMEII) Phase 1 air quality simulations SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID EASTERN UNITED-STATES; NORTH-AMERICA; DATA ASSIMILATION; EUROPE; PERFORMANCE; ENSEMBLE; OZONE; SCALE; EMISSIONS; TRANSPORT AB This study presents an evaluation of summertime ozone concentrations over North America (NA) and Europe (EU) using the database generated from Phase 1 of the Air Quality Model Evaluation International Initiative (AQMEII). The analysis focuses on identifying temporal and spatial features that can be used to stratify operational model evaluation metrics and to test the extent to which the various modeling systems can replicate the features seen in the observations. Using a synoptic map typing approach, it is demonstrated that model performance varies with meteorological conditions associated with specific synoptic-scale flow patterns over both eastern NA and EU. For example, the root mean square error of simulated daily maximum 8-hr ozone was twice as high when cloud fractions were high compared with when cloud fractions were low over eastern NA. Furthermore, results show that over both NA and EU the regional models participating in AQMEII were able to better reproduce the observed variance in ambient ozone levels than the global model used to specify chemical boundary conditions, although the variance simulated by almost all regional models is still less that the observed variance on all spatiotemporal scales. In addition, all modeling systems showed poor correlations with observed fluctuations on the intraday time scale over both NA and EU. Furthermore, a methodology is introduced to distinguish between locally influenced and regionally representative sites for the purpose of model evaluation. Results reveal that all models have worse model performance at locally influenced sites. Overall, the analyses presented in this paper show how observed temporal and spatial information can be used to stratify operational model performance statistics and to test the modeling systems' ability to replicate observed temporal and spatial features, especially at scales the modeling systems are designed to capture. Implications: The analyses presented in this paper demonstrate how observed temporal and spatial information can be used to stratify operational model performance and to test the modeling systems' ability to replicate observed temporal and spatial features. Decisions for the improvement of regional air quality models should be based on the information derived from only regionally representative sites. C1 [Hogrefe, C.; Roselle, S.; Mathur, R.; Rao, S. T.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Galmarini, S.] European Commiss Joint Res Ctr, Ispra, Italy. RP Hogrefe, C (reprint author), US EPA, Atmospher Modeling & Anal Div, Mail Drop E243-04, Res Triangle Pk, NC 27711 USA. EM hogrefe.christian@epa.gov NR 32 TC 8 Z9 8 U1 0 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD APR 3 PY 2014 VL 64 IS 4 BP 388 EP 405 DI 10.1080/10962247.2013.811127 PG 18 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AE5QW UT WOS:000334044800003 PM 24843911 ER PT J AU Liu, Z Bambha, RP Pinto, JP Zeng, T Boylan, J Huang, MY Lei, HM Zhao, C Liu, SS Mao, JF Schwalm, CR Shi, XY Wei, YX Michelsen, HA AF Liu, Zhen Bambha, Ray P. Pinto, Joseph P. Zeng, Tao Boylan, Jim Huang, Maoyi Lei, Huimin Zhao, Chun Liu, Shishi Mao, Jiafu Schwalm, Christopher R. Shi, Xiaoying Wei, Yaxing Michelsen, Hope A. TI Toward verifying fossil fuel CO2 emissions with the CMAQ model: Motivation, model description and initial simulation SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID CARBON-DIOXIDE; TRANSPORT MODELS; ATMOSPHERIC CO2; SINKS; UNCERTAINTIES; COMBUSTION; EXCHANGE; EUROPE; FLUXES; VPRM AB Motivated by the question of whether and how a state-of-the-art regional chemical transport model (CTM) can facilitate characterization of CO2 spatiotemporal variability and verify CO2 fossil-fuel emissions, we for the first time applied the Community Multiscale Air Quality (CMAQ) model to simulate CO2. This paper presents methods, input data, and initial results for CO2 simulation using CMAQ over the contiguous United States in October 2007. Modeling experiments have been performed to understand the roles of fossil-fuel emissions, biosphere-atmosphere exchange, and meteorology in regulating the spatial distribution of CO2 near the surface over the contiguous United States. Three sets of net ecosystem exchange (NEE) fluxes were used as input to assess the impact of uncertainty of NEE on CO2 concentrations simulated by CMAQ. Observational data from six tall tower sites across the country were used to evaluate model performance. In particular, at the Boulder Atmospheric Observatory (BAO), a tall tower site that receives urban emissions from Denver, CO, the CMAQ model using hourly varying, high-resolution CO2 fossil-fuel emissions from the Vulcan inventory and CarbonTracker optimized NEE reproduced the observed diurnal profile of CO2 reasonably well but with a low bias in the early morning. The spatial distribution of CO2 was found to correlate with NOx, SO2, and CO, because of their similar fossil-fuel emission sources and common transport processes. These initial results from CMAQ demonstrate the potential of using a regional CTM to help interpret CO2 observations and understand CO2 variability in space and time. The ability to simulate a full suite of air pollutants in CMAQ will also facilitate investigations of their use as tracers for CO2 source attribution. This work serves as a proof of concept and the foundation for more comprehensive examinations of CO2 spatiotemporal variability and various uncertainties in the future. Implications: Atmospheric CO2 has long been modeled and studied on continental to global scales to understand the global carbon cycle. This work demonstrates the potential of modeling and studying CO2 variability at fine spatiotemporal scales with CMAQ, which has been applied extensively, to study traditionally regulated air pollutants. The abundant observational records of these air pollutants and successful experience in studying and reducing their emissions may be useful for verifying CO2 emissions. Although there remains much more to further investigate, this work opens up a discussion on whether and how to study CO2 as an air pollutant. C1 [Liu, Zhen; Bambha, Ray P.; Michelsen, Hope A.] Sandia Natl Labs, CRF, Livermore, CA 94550 USA. [Pinto, Joseph P.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Zeng, Tao; Boylan, Jim] Georgia Dept Nat Resources, Atlanta, GA USA. [Huang, Maoyi; Lei, Huimin; Zhao, Chun] Pacific NW Natl Lab, Atmospher Sci & Global Change Div, Richland, WA 99352 USA. [Lei, Huimin] Tsinghua Univ, Dept Hydraul Engn, Beijing 100084, Peoples R China. [Liu, Shishi; Mao, Jiafu; Shi, Xiaoying; Wei, Yaxing] Oak Ridge Natl Lab, Oak Ridge, TN USA. [Schwalm, Christopher R.] No Arizona Univ, Sch Earth Sci & Environm Sustainabil, Flagstaff, AZ 86011 USA. RP Bambha, RP (reprint author), Sandia Natl Labs, CRF, 7011 East Ave, Livermore, CA 94550 USA. EM rpbambh@sandia.gov RI Liu, Zhen/C-3027-2011; Zhao, Chun/A-2581-2012; Huang, Maoyi/I-8599-2012; Lei, Huimin/H-9596-2015; Mao, Jiafu/B-9689-2012 OI Zhao, Chun/0000-0003-4693-7213; Huang, Maoyi/0000-0001-9154-9485; Lei, Huimin/0000-0002-1175-2334; Mao, Jiafu/0000-0002-2050-7373 FU Sandia Laboratory Directed Research and Development (LDRD) Program; National Nuclear Security Administration [DE-AC04-94-AL85000]; National Aeronautics and Space Administration (NASA) [NNX11AO08A, NNH10AN68I]; U.S. Department of Energy (DOE) by Battelle Memorial Institute [DE-AC06-76RLO1830] FX The work at Sandia National Laboratories was funded by the Sandia Laboratory Directed Research and Development (LDRD) Program. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the National Nuclear Security Administration under contract DE-AC04-94-AL85000. The WRF output and non-CO2 emission data are products of the Southeastern Modeling, Analysis, and Planning (SEMAP) project (http://www.metro4-sesarm.org; accessed January 14, 2013). The CLM4VIC output is a product of the MsTMIP project. The MsTMIP project has been funded by the National Aeronautics and Space Administration (NASA) under grants NNX11AO08A and NNH10AN68I, and is a contribution of the North American Carbon Program. PNNL is operated for the U.S. Department of Energy (DOE) by Battelle Memorial Institute under contract DE-AC06-76RLO1830. NR 58 TC 2 Z9 2 U1 1 U2 28 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD APR 3 PY 2014 VL 64 IS 4 BP 419 EP 435 DI 10.1080/10962247.2013.816642 PG 17 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AE5QW UT WOS:000334044800005 PM 24843913 ER PT J AU Sykes, KE Robinson, KN AF Sykes, Kathleen E. Robinson, Kristen N. TI Making the Right Moves: Promoting Smart Growth and Active Aging in Communities SO JOURNAL OF AGING & SOCIAL POLICY LA English DT Article DE active aging; aging in place; community health; smart growth AB This article describes an award program sponsored by the U.S. Environmental Protection Agency for excellence in smart growth and active aging. Having examined qualitative and quantitative data, we suggest that any community can foster changes to improve the health and well-being of its aging population. Diverse winners took unique paths to change their built environments and encourage physical activity. The policy changes undertaken by the award winners have both short- and long-term benefits that are important for persons of all ages, but especially for an aging society. C1 [Sykes, Kathleen E.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Robinson, Kristen N.] Social & Sci Syst Inc, Silver Spring, MD USA. RP Sykes, KE (reprint author), US EPA, Off Res & Dev, 1300 Penn Ave NW,Room 41284, Washington, DC 20460 USA. EM sykes.kathy@epa.gov NR 6 TC 0 Z9 0 U1 1 U2 25 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0895-9420 EI 1545-0821 J9 J AGING SOC POLICY JI J. Aging Soc. Policy PD APR 3 PY 2014 VL 26 IS 1-2 SI SI BP 166 EP 180 DI 10.1080/08959420.2014.854648 PG 15 WC Gerontology SC Geriatrics & Gerontology GA 302PP UT WOS:000330617700011 PM 24224800 ER PT J AU Johnstone, A Phillips, P Jarema, K Dheyongera, G Gordon, C AF Johnstone, Andrew Phillips, Pamela Jarema, Kimberly Dheyongera, Geoffrey Gordon, Christopher TI Effects of genetic strain on stress-induced weight and body fat loss in rats: application to air pollution research SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Dheyongera, Geoffrey] Jagiellonian Univ, Krakow, Poland. [Johnstone, Andrew; Phillips, Pamela; Jarema, Kimberly; Gordon, Christopher] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 703.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646703329 ER PT J AU Singh, A Boyle, MC Rubino, M Tandon, A Shah, R Archer, T AF Singh, Ajeet Boyle, Michael C. Rubino, Mark Tandon, Arpit Shah, Ruchir Archer, Trevor TI BRG1 deletion de-represses p53 pathways inducing cell cycle inhibition and apoptosis during peri-gastrulation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Singh, Ajeet; Boyle, Michael C.; Rubino, Mark; Archer, Trevor] Natl Inst Environm Hlth Sci, Durham, NC USA. [Tandon, Arpit; Shah, Ruchir] SRA Int, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 541.10 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646701304 ER PT J AU Vandenberg, LN Gerona, RR Kannan, K Taylor, JA van Breemen, RB Dickenson, CA Liao, CY Yuan, Y Newbold, RR Padmanabhan, V vom Saal, FS Woodruff, TJ AF Vandenberg, Laura N. Gerona, Roy R. Kannan, Kurunthachalam Taylor, Julia A. van Breemen, Richard B. Dickenson, Carrie A. Liao, Chunyang Yuan, Yang Newbold, Retha R. Padmanabhan, Vasantha vom Saal, Frederick S. Woodruff, Tracey J. TI A round robin approach to the analysis of bisphenol a (BPA) in human blood samples SO ENVIRONMENTAL HEALTH LA English DT Article DE Biomonitoring; Contamination; Endocrine disruptor; Linearity; Metabolite; Toxicokinetics ID ESTROGEN-RECEPTOR-ALPHA; TANDEM MASS-SPECTROMETRY; IN-VITRO FERTILIZATION; HUMAN EXPOSURE; ENVIRONMENTAL CHEMICALS; LIQUID-CHROMATOGRAPHY; ENDOCRINE DISRUPTORS; WIDESPREAD EXPOSURE; BIOLOGICAL SAMPLES; CIRCULATING LEVELS AB Background: Human exposure to bisphenol A (BPA) is ubiquitous, yet there are concerns about whether BPA can be measured in human blood. This Round Robin was designed to address this concern through three goals: 1) to identify collection materials, reagents and detection apparatuses that do not contribute BPA to serum; 2) to identify sensitive and precise methods to accurately measure unconjugated BPA (uBPA) and BPA-glucuronide (BPA-G), a metabolite, in serum; and 3) to evaluate whether inadvertent hydrolysis of BPA-G occurs during sample handling and processing. Methods: Four laboratories participated in this Round Robin. Laboratories screened materials to identify BPA contamination in collection and analysis materials. Serum was spiked with concentrations of uBPA and/or BPA-G ranging from 0.09-19.5 (uBPA) and 0.5-32 (BPA-G) ng/mL. Additional samples were preserved unspiked as 'environmental' samples. Blinded samples were provided to laboratories that used LC/MSMS to simultaneously quantify uBPA and BPA-G. To determine whether inadvertent hydrolysis of BPA metabolites occurred, samples spiked with only BPA-G were analyzed for the presence of uBPA. Finally, three laboratories compared direct and indirect methods of quantifying BPA-G. Results: We identified collection materials and reagents that did not introduce BPA contamination. In the blinded spiked sample analysis, all laboratories were able to distinguish low from high values of uBPA and BPA-G, for the whole spiked sample range and for those samples spiked with the three lowest concentrations (0.5-3.1 ng/ml). By completion of the Round Robin, three laboratories had verified methods for the analysis of uBPA and two verified for the analysis of BPA-G (verification determined by: 4 of 5 samples within 20% of spiked concentrations). In the analysis of BPA-G only spiked samples, all laboratories reported BPA-G was the majority of BPA detected (92.2 - 100%). Finally, laboratories were more likely to be verified using direct methods than indirect ones using enzymatic hydrolysis. Conclusions: Sensitive and accurate methods for the direct quantification of uBPA and BPA-G were developed in multiple laboratories and can be used for the analysis of human serum samples. BPA contamination can be controlled during sample collection and inadvertent hydrolysis of BPA conjugates can be avoided during sample handling. C1 [Vandenberg, Laura N.] Univ Massachusetts, Sch Publ Hlth, Div Environm Hlth Sci, Amherst, MA 01003 USA. [Gerona, Roy R.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Kannan, Kurunthachalam] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Kannan, Kurunthachalam] SUNY Albany, Albany, NY USA. [Taylor, Julia A.; vom Saal, Frederick S.] Univ Missouri, Div Biol Sci, Columbia, MO USA. [van Breemen, Richard B.; Yuan, Yang] Univ Illinois, Coll Pharm, Chicago, IL USA. [Dickenson, Carrie A.; Woodruff, Tracey J.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Program Reprod Hlth & Environm, San Francisco, CA 94117 USA. [Liao, Chunyang] NY State Dept Publ Hlth, Wadsworth Ctr, Albany, NY USA. [Newbold, Retha R.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA. [Padmanabhan, Vasantha] Univ Michigan, Reprod Sci Program, Ann Arbor, MI 48109 USA. RP Woodruff, TJ (reprint author), Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Program Reprod Hlth & Environm, San Francisco, CA 94117 USA. EM woodrufft@obgyn.ucsf.edu RI Padmanabhan, Vasantha/C-8558-2017 OI Padmanabhan, Vasantha/0000-0002-8443-7212 FU NIEHS [R21ES017763, R01 HD31544, 1P01 ES02284401, P20 ES018135, R01 ES017005]; NON ARRA SUPP [A112807]; NICHD [R01 HD021341]; USEPA [P20 STAR RD83467801, RD 83543601] FX The authors gratefully acknowledge helpful discussions and contributions from Dr. Jerrold Heindel and Dr. John Bucher throughout the process and conduct of the round robin and for the support they offered from NIEHS and NTP. We also thank Mr. Matthew Friesen, Mr. Ke Huang and Ms. Guannan Li for technical assistance. We acknowledge contributions from numerous scientists that participated in the earliest discussions of how to design a round robin analysis including Drs. Shanna Swan, Richard Stahlhut, Wade Welshons, Antonia Calafat, and Daniel Doerge. Finally, we acknowledge grant funding: NIEHS R21ES017763, R21ES017763 NON ARRA SUPP A112807, NIEHS R01 HD31544, NIEHS 1P01 ES02284401, NIEHS P20 ES018135, NIEHS R01 ES017005, NICHD R01 HD021341 and USEPA P20 STAR RD83467801 and RD 83543601. NR 93 TC 37 Z9 37 U1 2 U2 28 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD APR 1 PY 2014 VL 13 AR 25 DI 10.1186/1476-069X-13-25 PG 20 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AL1OE UT WOS:000338894000001 PM 24690217 ER PT J AU Awkerman, JA Cruz, S Proano, C Huyvaert, KP Uzcategui, GJ Baquero, A Wikelski, M Anderson, DJ AF Awkerman, Jill A. Cruz, Sebastian Proano, Carolina Huyvaert, Kathryn P. Jimenez Uzcategui, Gustavo Baquero, Andres Wikelski, Martin Anderson, David J. TI Small range and distinct distribution in a satellite breeding colony of the critically endangered Waved Albatross SO JOURNAL OF ORNITHOLOGY LA English DT Article DE Galapagos; La Plata; Seabird; Tracking; GPS; Accelerometer ID WANDERING ALBATROSSES; ENVIRONMENTAL VARIABILITY; PROVISIONING BEHAVIOR; PHOEBASTRIA-IRRORATA; ENERGY-EXPENDITURE; BODY ACCELERATION; ANIMALS; SEABIRD; CHICK; WIND AB To determine the proximate consequences of the limited breeding distribution of the critically endangered Waved Albatross (Phoebastria irrorata), we present continuous breeding season GPS tracks highlighting differences in behaviour, destinations, and distances travelled between three distinct colonies: two in Galapagos and one closer to the South American continent on Isla de la Plata, where a small number of pairs nest. Accelerometer data paired with GPS locations allowed operational classifications of Waved Albatross behaviour. All birds from Galapagos travelled eastward to the continental shelf and foraged southward along the Peruvian coast. Birds from Isla de la Plata made more and shorter foraging trips and used habitat north of the destinations of Galapagos birds. La Plata birds foraged in areas through which Galapagos birds commuted, and had slower average flight speeds and shorter commutes. Overall, albatrosses from La Plata might operate under a consistently lower return but they also incur lower costs compared to birds from Galapagos, which take fewer trips involving longer time investment. Galapagos birds may be able to forage more effectively based on more abundant or more profitable food patches in those highly productive areas. Foraging destinations of birds from the two Galapagos colonies were similar and overlapped areas that presented localized mortality risk from artisanal fisheries in previous years. This study, performed across the species' breeding range, reveals the different foraging distribution of La Plata albatrosses and the potential conservation value of this small colony in terms of maintenance of spatial diversity and behavioural plasticity. C1 [Awkerman, Jill A.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Cruz, Sebastian; Proano, Carolina; Wikelski, Martin] Max Planck Inst Ornithol, D-78315 Radolfzell am Bodensee, Germany. [Huyvaert, Kathryn P.] Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA. [Jimenez Uzcategui, Gustavo] Estn Cient Charles Darwin, Puerto Ayora, Galapagos, Ecuador. [Baquero, Andres] Univ San Francisco Quito, Quito, Ecuador. [Wikelski, Martin] Univ Konstanz, D-78457 Constance, Germany. [Anderson, David J.] Wake Forest Univ, Dept Biol, Winston Salem, NC 27109 USA. RP Awkerman, JA (reprint author), US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM Awkerman.Jill@epa.gov RI Huyvaert, Kathryn/A-2710-2009 OI Huyvaert, Kathryn/0000-0003-3302-030X FU National Science Foundation [DEB 0842199]; Max-Planck Society; State of Baden-Wuerttemberg Innovation; Colorado State University International Programs grant FX We thank the Galapagos National Park Service and the Ministry of the Environment of Ecuador for permission to work in the parks; Machalilla National Park, the Charles Darwin Research Station, Charles Darwin Foundation, and TAME Airlines for logistical support; Mathias Berger of Movebank for the albatross animation; Franz Kummeth for technical support; and anonymous reviewers for comments on an earlier draft. We also thank Christian Sevilla and rangers for assistance with albatross monitoring. This material is based upon work supported by National Science Foundation grant no. DEB 0842199 to DJA, Max-Planck Society and State of Baden-Wuerttemberg Innovation funding to MW, and a Colorado State University International Programs grant to KPH. NR 40 TC 0 Z9 1 U1 5 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0021-8375 EI 1439-0361 J9 J ORNITHOL JI J. Ornithol. PD APR PY 2014 VL 155 IS 2 BP 367 EP 378 DI 10.1007/s10336-013-1013-9 PG 12 WC Ornithology SC Zoology GA AJ6HM UT WOS:000337792000005 ER PT J AU Dawson, JP Bloomer, BJ Winner, DA Weaver, CP AF Dawson, John P. Bloomer, Bryan J. Winner, Darrell A. Weaver, Christopher P. TI UNDERSTANDING THE METEOROLOGICAL DRIVERS OF US PARTICULATE MATTER CONCENTRATIONS IN A CHANGING CLIMATE SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Editorial Material ID SECONDARY ORGANIC AEROSOL; UNITED-STATES IMPLICATIONS; AIR-QUALITY; ISOPRENE EMISSION; REGIONAL CLIMATE; OZONE CONCENTRATIONS; WILDFIRE ACTIVITY; SURFACE OZONE; NORTH-AMERICA; POLLUTION C1 [Dawson, John P.; Bloomer, Bryan J.; Winner, Darrell A.; Weaver, Christopher P.] US EPA, Off Res & Dev, Arlington, VA USA. RP Weaver, CP (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave NW,Mail Stop 8601-P, Washington, DC 20460 USA. EM weaver.chris@epa.gov RI Weaver, Christopher/G-3714-2010 OI Weaver, Christopher/0000-0003-4016-5451 NR 86 TC 15 Z9 15 U1 0 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD APR PY 2014 VL 95 IS 4 BP 520 EP 532 DI 10.1175/BAMS-D-12-00181.1 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AI8MK UT WOS:000337170300004 ER PT J AU Pleim, J Mathur, R Rao, ST Fast, J Baklanov, A AF Pleim, Jonathan Mathur, Rohit Rao, S. T. Fast, Jerome Baklanov, Alexander TI INTEGRATED METEOROLOGY AND CHEMISTRY MODELING Evaluation and Research Needs SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Editorial Material C1 [Pleim, Jonathan; Mathur, Rohit] US EPA, Res Triangle Pk, NC 27711 USA. [Rao, S. T.] N Carolina State Univ, Raleigh, NC 27695 USA. [Fast, Jerome] Pacific NW Natl Lab, Richland, WA 99352 USA. [Baklanov, Alexander] Danish Meteorol Inst, Lyngbyvej, Denmark. RP Pleim, J (reprint author), US EPA, E243-03, Res Triangle Pk, NC 27711 USA. EM pleim.jon@epa.gov RI Pleim, Jonathan Pleim/C-1331-2017 OI Pleim, Jonathan Pleim/0000-0001-6190-6082 NR 6 TC 0 Z9 0 U1 3 U2 10 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD APR PY 2014 VL 95 IS 4 BP ES81 EP ES84 DI 10.1175/BAMS-D-13-00107.1 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AI8MK UT WOS:000337170300001 ER PT J AU Oczkowski, A Markham, E Hanson, A Wigand, C AF Oczkowski, Autumn Markham, Erin Hanson, Alana Wigand, Cathleen TI Carbon stable isotopes as indicators of coastal eutrophication SO ECOLOGICAL APPLICATIONS LA English DT Article DE carbon; C-13; estuary; eutrophication; mesocosm experiments; monitoring; Naragansett Bay; Rhode Island; USA; phytoplankton production; Spartina alterniflora; stable isotope; Typhus angustifolia ID NARRAGANSETT BAY; WATERSHED INFLUENCES; MARINE ECOSYSTEM; ORGANIC-MATTER; NORTH PACIFIC; BALTIC SEA; FOOD WEBS; NITROGEN; PHYTOPLANKTON; FRACTIONATION AB Coastal ecologists and managers have frequently used nitrogen stable isotopes (N-15) to trace and monitor sources of anthropogenic nitrogen (N) in coastal ecosystems. However, the interpretation of N-15 data can often be challenging, as the isotope values fractionate substantially due to preferential retention and uptake by biota. There is a growing body of evidence that carbon isotopes may be a useful alternative indicator for eutrophication, as they may be sensitive to changes in primary production that result from anthropogenic nutrient inputs. We provide three examples of systems where C-13 values sensitively track phytoplankton production. First, earlier (1980s) mesocosm work established positive relationships between C-13 and dissolved inorganic nitrogen and dissolved silica concentrations. Consistent with these findings, a contemporary mesocosm experiment designed to replicate a temperate intertidal salt marsh environment also demonstrated that the system receiving supplementary nutrient additions had higher nutrient concentrations, higher chlorophyll concentrations, and higher C-13 values. This trend was particularly pronounced during the growing season, with differences less evident during senescence. And finally, these results were replicated in the open waters of Narragansett Bay, Rhode Island, USA, during a spring phytoplankton bloom. These three examples, taken together with the pre-existing body of literature, suggest that, at least in autotrophic, phytoplankton-dominated systems, C-13 values can be a useful and sensitive indicator of eutrophication. C1 [Oczkowski, Autumn; Hanson, Alana; Wigand, Cathleen] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Markham, Erin] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. RP Oczkowski, A (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM Oczkowski.autumn@epa.gov FU U.S. Environmental Protection Agency FX We thank David Katz, Monique Perron, Rick McKinney, Jason Grear, Roxanne Johnson, Emily Seelen, Chitanya Gopu, Lauren Rothermich, Elizabeth Watson, Earl Davey, and Kirk Silver for assistance with mesocosm maintenance, sample collection and analysis. We also thank the EPA Facility Group for plumbing, maintaining, and improving our mesocosm facility. The manuscript has been much improved with suggestions made by Daniel Campbell, Elizabeth Watson, Rick McKinney, and two anonymous reviewers. This is tracking number ORD-003513 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency. Although the research described in this article has been funded in part by the U.S. Environmental Protection Agency to Autumn Oczkowski, it has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. NR 51 TC 2 Z9 2 U1 6 U2 45 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1051-0761 EI 1939-5582 J9 ECOL APPL JI Ecol. Appl. PD APR PY 2014 VL 24 IS 3 BP 457 EP 466 DI 10.1890/13-0365.1 PG 10 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA AD4TA UT WOS:000333242300004 PM 24834733 ER PT J AU Morgan, MK Wilson, NK Chuang, JC AF Morgan, Marsha K. Wilson, Nancy K. Chuang, Jane C. TI Exposures of 129 Preschool Children to Organochlorines, Organophosphates, Pyrethroids, and Acid Herbicides at Their Homes and Daycares in North Carolina SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE children; pesticides; exposure; intake dose; residences; daycare centers ID PERSISTENT ORGANIC POLLUTANTS; DAY-CARE-CENTERS; 2,4-DICHLOROPHENOXYACETIC ACID; EVERYDAY ENVIRONMENTS; AGGREGATE EXPOSURES; YOUNG-CHILDREN; CHLORPYRIFOS; 2,4-D; CYPERMETHRIN; INSECTICIDE AB Few data exist on the concurrent exposures of young children to past-use and current-use pesticides in their everyday environments. In this further analysis of study data, we quantified the potential exposures and intake doses of 129 preschool children, ages 20 to 66 months, to 16 pesticides (eight organochlorines, two organophosphates, three pyrethroids, and three acid herbicides). Environmental samples (soil, dust, outdoor air, and indoor air) and personal samples (hand wipes, solid food, and liquid food) were collected at 129 homes and 13 daycare centers in six counties in North Carolina between 2000 and 2001. alpha-Chlordane, gamma-chlordane, heptachlor, chlorpyrifos, diazinon, cis-permethrin, trans-permethrin, and 2,4-dichlorophenoxyacetic acid (2,4-D) were detected >= 50% in two or more media in both settings. Of these pesticides, the children's estimated median potential intake doses through dietary ingestion, nondietary ingestion, and inhalation routes were the highest for 2,4-D and cis/trans-permethrin (both 4.84 ng/kg/day), cis/trans-permethrin (2.39 ng/kg/day), and heptachlor (1.71 ng/kg/day), respectively. The children's estimated median potential aggregate intake doses by all three routes were quantifiable for chlorpyrifos (4.6 ng/kg/day), cis/trans-permethrin (12.5 ng/kg/day), and 2,4-D (4.9 ng/kg/day). In conclusion, these children were likely exposed daily to several pesticides from several sources and routes at their homes and daycares. C1 [Morgan, Marsha K.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Wilson, Nancy K.] Battelle Mem Inst, Durham, NC 27713 USA. [Chuang, Jane C.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Morgan, MK (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM morgan.marsha@epa.gov; njkwilson@nc.rr.com; ccjane20@hotmail.com FU United States Environmental Protection Agency through Office of Research and Development [68-D-99-011] FX We would like to thank the children, their parents, and the daycare teachers for participating in this study which has generated a wealth of data on young children's exposures to pesticides in their everyday environments. We would also like to especially thank Linda Sheldon for her valuable scientific insights and technical contributions to this paper. Disclaimer: The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under Contract #68-D-99-011 to Battelle. It has been subjected to agency review and approved for publication. NR 31 TC 9 Z9 10 U1 6 U2 23 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD APR PY 2014 VL 11 IS 4 BP 3743 EP 3764 DI 10.3390/ijerph110403743 PG 22 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AG9TM UT WOS:000335762700056 PM 24705361 ER PT J AU Evans, AM Rice, GE Teuschler, LK Wright, JM AF Evans, Amanda M. Rice, Glenn E. Teuschler, Linda K. Wright, J. Michael TI Joint Exposure to Chemical and Nonchemical Neurodevelopmental Stressors in U. S. Women of Reproductive Age in NHANES SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE allostatic load (AL); chronic stress; cumulative exposure assessment; cumulative risk assessment (CRA); hazard index (HI); nonchemical stressors; neurodevelopment; physiological dysregulation; susceptibility; vulnerability ID NUTRITION EXAMINATION SURVEY; ALLOSTATIC LOAD; LEAD-EXPOSURE; BLOOD LEAD; PRENATAL EXPOSURE; AIR-POLLUTION; PHYSIOLOGICAL DYSREGULATION; ENVIRONMENTAL LEAD; NATIONAL-HEALTH; RISK-ASSESSMENT AB Lead (Pb) and methyl mercury (MeHg) are well established neurodevelopmental toxicants (NDTs), but joint exposure to chemical and nonchemical (e.g., maternal stress) stressors has rarely been considered. We characterized exposure to Pb, MeHg and a measure of physiological dysregulation associated with chronic stress and examined race/ethnicity as a predictor of joint NDT exposure. Using data from the 2003-2004 NHANES, potential chronic stress exposure was estimated using allostatic load (AL), a quantitative measure of physiological dysregulation. A Hazard Index was calculated for joint exposure to Pb and MeHg (HINDT). Logistic regression was used to assess the relationship between an indicator of elevated joint NDT exposures (HINDT > 1) and race/ethnicity. The multivariate model was stratified by AL groups to examine effect measure modification. African American (adjusted odds ratio [OR] [95% confidence interval] = 2.2 [1.4, 3.3]) and Mexican American (1.4 [0.7, 2.6]) women were more likely to have an HINDT > 1 compared to Caucasian women. Chronic stress was identified as an effect measure modifier with the largest ORs among women with high AL scores (African Americans = 4.3 [2.0, 9.5]; Mexican Americans = 4.2 [1.3, 14.1]). Chronic stress was found to modify the association between elevated joint NDT exposure and race/ethnicity, highlighting the importance of evaluating chemical and nonchemical stressor exposures leading to a common endpoint. C1 [Evans, Amanda M.] US EPA, ORISE, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Rice, Glenn E.; Wright, J. Michael] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Teuschler, Linda K.] Linda Teuschler & Associates, St Petersburg, FL 33707 USA. RP Evans, AM (reprint author), US EPA, ORISE, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. EM Evans.AmandaM@epa.gov; Rice.Glenn@epa.gov; lindateuschler@gmail.com; Wright.Michael@epa.gov FU National Center for Environmental Assessment, Office of Research and Development, U.S. EPA FX We would like to thank Rita Schoeny and Deborah Cory-Slechta for their helpful comments on earlier versions of this manuscript. This project was supported in part by an appointment to the Research Participation Program at the National Center for Environmental Assessment, Office of Research and Development, U.S. EPA, administered by ORISE through an interagency agreement between the U.S. Department of Energy and U.S. EPA. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the EPA. NR 45 TC 4 Z9 4 U1 1 U2 7 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD APR PY 2014 VL 11 IS 4 BP 4384 EP 4401 DI 10.3390/ijerph110404384 PG 18 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AG9TM UT WOS:000335762700046 PM 24758893 ER PT J AU Barraza-Villarreal, A Escamilla-Nunez, MC Schilmann, A Hernandez-Cadena, L Li, Z Romanoff, L Sjodin, A Del Rio-Navarro, BE Diaz-Sanchez, D Diaz-Barriga, F Sly, P Romieu, I AF Barraza-Villarreal, Albino Consuelo Escamilla-Nunez, Maria Schilmann, Astrid Hernandez-Cadena, Leticia Li, Zheng Romanoff, Lovisa Sjoedin, Andreas Estela Del Rio-Navarro, Blanca Diaz-Sanchez, David Diaz-Barriga, Fernando Sly, Peter Romieu, Isabelle TI Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren A Pilot Study SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CITY; CHILDREN; COHORT; POLLUTANTS; POLLUTION; GROWTH; CANCER AB Objective: To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. Methods: A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models. Results: A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (-11.2 mL, 95% CI: -22.2 to -0.02), forced vital capacity (-11.6 mL, 95% CI: -22.9 to -0.2), and pH of EBC (-0.035, 95% CI: -0.066 to -0.005). Conclusion: Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren. C1 [Barraza-Villarreal, Albino; Consuelo Escamilla-Nunez, Maria; Schilmann, Astrid; Hernandez-Cadena, Leticia; Romieu, Isabelle] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico. [Li, Zheng; Romanoff, Lovisa; Sjoedin, Andreas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Estela Del Rio-Navarro, Blanca] Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico. [Diaz-Sanchez, David] US EPA, Res Triangle Pk, NC 27711 USA. [Diaz-Barriga, Fernando] Univ Autonoma San Luis Potosi, San Luis Potosi, Mexico. [Sly, Peter] Univ Western Australia, Div Clin Sci, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia. Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6009, Australia. [Romieu, Isabelle] Int Agcy Res Canc, F-69372 Lyon 08, France. RP Romieu, I (reprint author), Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France. EM romieui@iarc.fr RI Sjodin, Andreas/F-2464-2010; Sly, Peter/F-1486-2010 OI Sly, Peter/0000-0001-6305-2201 FU Mexican Sciences and Technology Council (CONACYT) [38911-M, 2002-C01-7624] FX The study was supported by the Mexican Sciences and Technology Council (CONACYT) grant 38911-M and 2002-C01-7624. NR 22 TC 6 Z9 6 U1 0 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD APR PY 2014 VL 56 IS 4 BP 415 EP 419 DI 10.1097/JOM.0000000000000111 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6ZJ UT WOS:000335567400018 PM 24500378 ER PT J AU Yager, TJB Furlong, ET Kolpin, DW Kinney, CA Zaugg, SD Burkhardt, MR AF Yager, Tracy J. B. Furlong, Edward T. Kolpin, Dana W. Kinney, Chad A. Zaugg, Steven D. Burkhardt, Mark R. TI DISSIPATION OF CONTAMINANTS OF EMERGING CONCERN IN BIOSOLIDS APPLIED TO NONIRRIGATED FARMLAND IN EASTERN COLORADO(1) SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE organic chemicals; soils; transport and fate; biosolids; crops; field dissipation ID PERSONAL CARE PRODUCTS; ENDOCRINE-DISRUPTING CHEMICALS; WASTE-WATER CONTAMINANTS; MUNICIPAL BIOSOLIDS; LAND APPLICATION; SEWAGE-SLUDGE; AMENDED SOILS; FATHEAD MINNOWS; CROP PLANTS; PHARMACEUTICALS AB In 2007, a 1.5-year field-scale study was initiated by the U.S. Geological Survey to evaluate the dissipation of contaminants of emerging concern (CECs) following a first agronomic biosolids application to nonirrigated farmland. CECs with the greatest decrease in concentration in the surface biosolids at 180days post-application included indole, d-limonene, p-cresol, phenol, and skatol. CECs that were present in the largest concentration in 180-day-weathered biosolids included stanols, nonylphenols, bisphenol A, bis(2-ethylhexyl) phthalate, hexahydrohexamethyl cyclopenta-benzopyran (HHCB), and triclosan. CECs that were detected in pre-application soil were 3-beta coprostanol, skatol, acetophenone, beta-sitosterol, beta-stigmastanol, cholesterol, indole, p-cresol, and phenol, most of which are biogenic sterols or fragrances that have natural plant sources in addition to anthropogenic sources, yet their concentrations increased (in some cases, substantially) following biosolids application. Preliminary data indicate the nonylphenols (including NPEO1, NPEO2), OPEO1, benzo[a]pyrene, diethyl phthalate, d-limonene, HHCB, triclosan, and possibly 3-beta coprostanol, skatol, beta-sitosterol, cholesterol, indole, and p-cresol, migrated downward through the soil by 468days post-application, but indicated little uptake by mature wheat plants. This study indicates that some CECs are sufficiently persistent and mobile to be vertically transported into the soil column following biosolids applications to the land surface, even in semiarid regions. C1 [Yager, Tracy J. B.; Furlong, Edward T.; Zaugg, Steven D.] US Geol Survey, Denver Fed Ctr, Lakewood, CO 80225 USA. [Kolpin, Dana W.] US Geol Survey, Iowa City, IA 52244 USA. [Kinney, Chad A.] Colorado State Univ, Pueblo, CO 81001 USA. [Burkhardt, Mark R.] US EPA, Reg Lab 8, Golden, CO 80403 USA. [Burkhardt, Mark R.] US Geol Survey, Denver, CO 80225 USA. RP Yager, TJB (reprint author), US Geol Survey, Denver Fed Ctr, Box 25046 MS415, Lakewood, CO 80225 USA. EM tjyager@usgs.gov FU USGS National Toxics Program FX The authors thank the WWTP and the farmer at this site for participating in this study. The authors thank the USGS National Toxics Program for supporting the study. The authors thank V. Cory Stephens, Mary Kochivar, Patricia Oaks, Julia Glovack, Clay Thompson, and Stephen Werner for assistance in surveying and sample collection. Any use of trade names is for descriptive purposes only and does not imply endorsement by the U.S. Government. It is with great sadness that we note that our colleague and coauthor, Steven D. Zaugg, passed away before the publication of this article. NR 54 TC 5 Z9 5 U1 4 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD APR PY 2014 VL 50 IS 2 BP 343 EP 357 DI 10.1111/jawr.12163 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AE0WM UT WOS:000333687000009 ER PT J AU Zhang, Y Shuster, W AF Zhang, Yu Shuster, William TI THE COMPARATIVE ACCURACY OF TWO HYDROLOGIC MODELS IN SIMULATING WARM-SEASON RUNOFF FOR TWO SMALL, HILLSLOPE CATCHMENTS(1) SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE stormwater; micro-catchment; distributed model; runoff; calibration ID WATER; FLOW; URBANIZATION; PARAMETERS; SYSTEMS; IMPACT; SOILS; SCALE; SWMM AB This article assesses the performance of two hydrologic models in simulating warm-season runoff for two upland, low-yield micro-catchments near Coshocton, Ohio. The two models, namely the Storm Water Management Model (SWMM) and the Gridded Surface-Subsurface Hydrologic Analysis (GSSHA), were implemented with contrasting levels of complexity, with the former representing the catchments as lumped spatial units and computing evaporation only from standing water, and the latter incorporating fine-scale variation in topography and soil properties and computing evapotranspiration from soil based on weather data. Our investigation began with uncalibrated model runs for 1990-2003 except for 1994 using a priori parameter values. Then a set of calibration experiments were performed wherein the sensitivity of model performance to the length of calibration records was examined. Our results pointed to large errors associated with simulations from both models: even the calibrated models were unable to reproduce the seasonal and between-catchment contrasts in runoff response. Using a priori parameter values, SWMM attained better results than GSSHA. However, with simple calibration, GSSHA outperformed SWMM in several respects. It was also found that extending the record of calibration rendered relatively minor changes to model performance. The practical and scientific implications of the findings are discussed. C1 [Zhang, Yu] Oak Ridge Inst Sci & Educ, Cincinnati, OH 45268 USA. [Shuster, William] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Zhang, Y (reprint author), NOAA, Natl Weather Serv, 1325 East West Hwy, Silver Spring, MD 20910 USA. EM yu.zhang@noaa.gov FU USEPA through the Coshocton Urbanization Project; Oak Ridge Institute for Science and Education FX The research was funded by USEPA through the Coshocton Urbanization Project. The postdoctoral research associate position was funded by Oak Ridge Institute for Science and Education. We also thank Dr. James V. Bonta for providing the data and critical suggestions. Drs. Fred L. Ogden and Justin Niedzialek at University of Connecticut, and Mr. Aaron Byrd at the US Army Corp of Engineers for providing technical assistance to the implementation of GSSHA model. Three anonymous reviewers provided valuable suggestions and their contributions are graciously acknowledged here. NR 39 TC 1 Z9 1 U1 2 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD APR PY 2014 VL 50 IS 2 BP 434 EP 447 DI 10.1111/jawr.12135 PG 14 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AE0WM UT WOS:000333687000015 ER PT J AU Seren, N Glaberman, S Carretero, MA Chiari, Y AF Seren, Nina Glaberman, Scott Carretero, Miguel A. Chiari, Ylenia TI Molecular Evolution and Functional Divergence of the Metallothionein Gene Family in Vertebrates SO JOURNAL OF MOLECULAR EVOLUTION LA English DT Article DE CDS; Functional analysis; Gene duplication; Gene tree; Genomic database; Reconciliation ID METAL-BINDING FEATURES; MAXIMUM-LIKELIHOOD; MAMMALIAN METALLOTHIONEIN; MESSENGER-RNA; PHYLOGENETIC ANALYSIS; DUPLICATION; EXPRESSION; PROTEIN; MODELS; SELECTION AB The metallothionein (MT) gene superfamily consists of metal-binding proteins involved in various metal detoxification and storage mechanisms. The evolution of this gene family in vertebrates has mostly been studied in mammals using sparse taxon or gene sampling. Genomic databases and available data on MT protein function and expression allow a better understanding of the evolution and functional divergence of the different MT types. We recovered 77 MT coding sequences from 20 representative vertebrates with annotated complete genomes. We found multiple MT genes, also in reptiles, which were thought to have only one MT type. Phylogenetic and synteny analyses indicate the existence of a eutherian MT1 and MT2, a tetrapod MT3, an amniote MT4, and fish MT. The optimal gene-tree/species-tree reconciliation analyses identified the best root in the fish clade. Functional analyses reveal variation in hydropathic index among protein domains, likely correlated with their distinct flexibility and metal affinity. Analyses of functional divergence identified amino acid sites correlated with functional divergence among MT types. Uncovering the number of genes and sites possibly correlated with functional divergence will help to design cost-effective MT functional and gene expression studies. This will permit further understanding of the distinct roles and specificity of these proteins and to properly target specific MT for different types of functional studies. Therefore, this work presents a critical background on the molecular evolution and functional divergence of vertebrate MTs to carry out further detailed studies on the relationship between heavy metal metabolism and tolerances among vertebrates. C1 [Seren, Nina; Carretero, Miguel A.; Chiari, Ylenia] Univ Porto, CIBIO, Ctr Invest Biodiversidade & Recursos Genet Campus, P-4485661 Vairao, Portugal. [Glaberman, Scott] US EPA, Off Pesticide Programs MC 7507P, Washington, DC 20460 USA. [Chiari, Ylenia] Univ S Alabama, Dept Biol, Mobile, AL 36688 USA. RP Chiari, Y (reprint author), Univ S Alabama, Dept Biol, LSCB 123,5871 USA Dr N, Mobile, AL 36688 USA. EM yle@yleniachiari.it RI Carretero, Miguel/A-1472-2013; OI Carretero, Miguel/0000-0002-2335-7198; Seren, Nina/0000-0003-0207-8437 FU FCT (Fundacao para Ciencia e Tecnologia, Portugal) [SFRH/BDP/73515/2010] FX We are thankful to M Fonseca, N. Galtier, JM Lourenco, B Nabholz, S Rocha, D Salvi, and Z Yang for feedback on this work. We are grateful to J-P Doyon for his help with the reconciliation analysis and his comments on this part. We are thankful to an anonymous reviewer for comments on an early version of this manuscript. YC was partially financially supported by a FCT (Fundacao para Ciencia e Tecnologia, Portugal) postdoctoral fellowship SFRH/BDP/73515/2010. NR 86 TC 3 Z9 4 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2844 EI 1432-1432 J9 J MOL EVOL JI J. Mol. Evol. PD APR PY 2014 VL 78 IS 3-4 BP 217 EP 233 DI 10.1007/s00239-014-9612-5 PG 17 WC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity GA AH1NL UT WOS:000335887500005 PM 24557429 ER PT J AU Cowie, R Williams, MW Wireman, M Runkel, RL AF Cowie, Rory Williams, Mark W. Wireman, Mike Runkel, Robert L. TI Use of Natural and Applied Tracers to Guide Targeted Remediation Efforts in an Acid Mine Drainage System, Colorado Rockies, USA SO WATER LA English DT Article DE groundwater; acid mine drainage; water isotopes; mine hydrology; fluorescent dye tracers; stream tracers ID GROUNDWATER TRACERS; FLUORESCENT DYES; WATER; TRANSPORT; AQUIFERS; CREEK; INJECTION; LOADS AB Stream water quality in areas of the western United States continues to be degraded by acid mine drainage (AMD), a legacy of hard-rock mining. The Rico-Argentine Mine in southwestern Colorado consists of complex multiple-level mine workings connected to a drainage tunnel discharging AMD to passive treatment ponds that discharge to the Dolores River. The mine workings are excavated into the hillslope on either side of a tributary stream with workings passing directly under the stream channel. There is a need to define hydrologic connections between surface water, groundwater, and mine workings to understand the source of both water and contaminants in the drainage tunnel discharge. Source identification will allow targeted remediation strategies to be developed. To identify hydrologic connections we employed a combination of natural and applied tracers including isotopes, ionic tracers, and fluorescent dyes. Stable water isotopes (delta O-18/delta D) show a well-mixed hydrological system, while tritium levels in mine waters indicate a fast flow-through system with mean residence times of years not decades or longer. Addition of multiple independent tracers indicated that water is traveling through mine workings with minimal obstructions. The results from a simultaneous salt and dye tracer application demonstrated that both tracer types can be successfully used in acidic mine water conditions. C1 [Cowie, Rory; Williams, Mark W.] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [Wireman, Mike] US EPA, Denver, CO 80202 USA. [Runkel, Robert L.] US Geol Survey, Boulder, CO 80303 USA. RP Cowie, R (reprint author), Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. EM rory.cowie@colorado.edu; markw@snobear.colorado.edu; wireman.mike@epa.gov; runkel@usgs.gov NR 49 TC 6 Z9 6 U1 6 U2 31 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD APR PY 2014 VL 6 IS 4 BP 745 EP 777 DI 10.3390/w6040745 PG 33 WC Water Resources SC Water Resources GA AG9TD UT WOS:000335761800001 ER PT J AU Magnus, MC DeRoo, LA Haberg, SE Magnus, P Nafstad, P Nystad, W London, SJ AF Magnus, Maria C. DeRoo, Lisa A. Haberg, Siri E. Magnus, Per Nafstad, Per Nystad, Wenche London, Stephanie J. TI Prospective Study ofMaternal Alcohol Intake During Pregnancy or Lactation and Risk of Childhood Asthma: The NorwegianMother and Child Cohort Study SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Alcohol; Asthma; Breastfeeding; Pregnancy; Respiratory Tract Infections ID UTERO ETHANOL EXPOSURE; ALVEOLAR MACROPHAGE; PULMONARY-FUNCTION; SELECTION BIAS; CONSUMPTION; LUNG; INFECTIONS; NEWBORNS; BIRTH; DRINK AB BackgroundMany women drink during pregnancy and lactation despite recommendations to abstain. In animals, alcohol exposure during pregnancy and lactation influences lung and immune development, plausibly increasing risk of asthma and lower respiratory tract infections (LRTIs). Studies in humans are few. MethodsIn the Norwegian Mother and Child Cohort Study, we examined maternal alcohol intake during pregnancy and lactation in relation to risk of current asthma at 36months (49,138 children), recurrent LRTIs by 36months (39,791 children), and current asthma at 7years (13,253 children). Mothers reported frequency and amount of alcohol intake each trimester and the first 3months following delivery. We calculated adjusted relative risk (aRR), comparing children of drinkers to nondrinkers, using Generalized Linear Models. ResultsA total of 31.8% of mothers consumed alcohol during first trimester, 9.7% during second trimester, and 15.6% during third trimester. Infrequent and low-dose prenatal alcohol exposure showed a modest statistically significant inverse association with current asthma at 36months (aRRs0.85). No association was seen with the highest alcohol intakes during the first trimester when alcohol consumption was most common. RRs of maternal alcohol intake during pregnancy with recurrent LRTIs were 1, with sporadic differences in risk for some metrics of intake, but without any consistent pattern. For current asthma at 7years, similar inverse associations were seen as with current asthma at 36months but were not statistically significant. Among children breastfed throughout the first 3months of life, maternal alcohol intake during this time was not significantly associated with any of the 3 outcomes. ConclusionsThe low levels of alcohol exposure during pregnancy or lactation observed in this cohort were not associated with increased risk of asthma or recurrent LRTIs. The slight inverse associations of infrequent or low-dose prenatal alcohol exposure with asthma may not be causal. C1 [Magnus, Maria C.; Haberg, Siri E.; Magnus, Per; Nafstad, Per; Nystad, Wenche] Norwegian Inst Publ Hlth, Dept Chron Dis, Div Epidemiol, N-0403 Oslo, Norway. [Magnus, Maria C.; DeRoo, Lisa A.; London, Stephanie J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Div Intramural Res, NIH,Dept Hlth & Human Serv, Res Triangle Pk, NC USA. [DeRoo, Lisa A.] Univ Bergen, Fac Med, Dept Global Publ Hlth & Primary Care, Bergen, Norway. [Nafstad, Per] Univ Oslo, Fac Med, Dept Community Med, Oslo, Norway. RP Magnus, MC (reprint author), Norwegian Inst Publ Hlth, Dept Chron Dis, Div Epidemiol, POB 4404 Nydalen, N-0403 Oslo, Norway. EM maria.christine.magnus@fhi.no OI London, Stephanie/0000-0003-4911-5290 FU NIH (NIH/NIEHS) [N01-ES-75558]; NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]; Norwegian Research Council/FUGE [151918/S10]; Norwegian Extra-Foundation for Health and Rehabilitation [2011.2.0218]; Intramural Program of the National Institutes of Health, National Institute of Environmental Health Sciences FX The authors are grateful to all the families participating in the ongoing Norwegian Mother and Child Cohort Study. The Norwegian Mother and Child Cohort Study is supported by NIH (NIH/NIEHS contract number N01-ES-75558, NIH/NINDS grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1) and the Norwegian Research Council/FUGE (grant number 151918/S10). MCM is also supported by the Norwegian Extra-Foundation for Health and Rehabilitation (grant number 2011.2.0218). This research was supported in part by the Intramural Program of the National Institutes of Health, National Institute of Environmental Health Sciences. NR 45 TC 7 Z9 7 U1 3 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD APR PY 2014 VL 38 IS 4 BP 1002 EP 1011 DI 10.1111/acer.12348 PG 10 WC Substance Abuse SC Substance Abuse GA AE4JJ UT WOS:000333948400012 PM 24460824 ER PT J AU Pottenger, LH Andrews, LS Bachman, AN Boogaard, PJ Cadet, J Embry, MR Farmer, PB Himmelstein, MW Jarabek, AM Martin, EA Mauthe, RJ Persaud, R Preston, RJ Schoeny, R Skare, J Swenberg, JA Williams, GM Zeiger, E Zhang, F Kim, JH AF Pottenger, Lynn H. Andrews, Larry S. Bachman, Ammie N. Boogaard, Peter J. Cadet, Jean Embry, Michelle R. Farmer, Peter B. Himmelstein, Matthew W. Jarabek, Annie M. Martin, Elizabeth A. Mauthe, Robert J. Persaud, Rudranath Preston, R. Julian Schoeny, Rita Skare, Julie Swenberg, James A. Williams, Gary M. Zeiger, Errol Zhang, Fagen Kim, James H. TI An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B-1, tamoxifen and vinyl chloride SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE Biomarkers; cancer; DNA adducts; mode of action; risk assessment ID BREAST-CANCER PATIENTS; SPRAGUE-DAWLEY RATS; REPUBLIC-OF-CHINA; HEPATITIS-B-VIRUS; GLUTATHIONE-S-TRANSFERASE; DOSE-RESPONSE RELATIONSHIPS; DILUTION MASS-SPECTROMETRY; NUCLEOTIDE EXCISION-REPAIR; HUMAN LIVER-CANCER; PERFORMANCE LIQUID-CHROMATOGRAPHY AB The framework analysis previously presented for using DNA adduct information in the risk assessment of chemical carcinogens was applied in a series of case studies which place the adduct information into context with the key events in carcinogenesis to determine whether they could be used to support a mutagenic mode of action (MOA) for the examined chemicals. Three data-rich chemicals, aflatoxin B-1 (AFB(1)), tamoxifen (Tam) and vinyl chloride (VCl) were selected for this exercise. These chemicals were selected because they are known human carcinogens and have different characteristics: AFB(1) forms a unique adduct and human exposure is through contaminated foods; Tam is a pharmaceutical given to women so that the dose and duration of exposure are known, forms unique adducts in rodents, and has both estrogenic and genotoxic properties; and VCl, to which there is industrial exposure, forms a number of adducts that are identical to endogenous adducts found in unexposed people. All three chemicals produce liver tumors in rats. AFB(1) and VCl also produce liver tumors in humans, but Tam induces human uterine tumors, only. To support a mutagenic MOA, the chemical-induced adducts must be characterized, shown to be pro-mutagenic, be present in the tumor target tissue, and produce mutations of the class found in the tumor. The adducts formed by AFB(1) and VCl support a mutagenic MOA for their carcinogenicity. However, the data available for Tam shows a mutagenic MOA for liver tumors in rats, but its carcinogenicity in humans is most likely via a different MOA. C1 [Pottenger, Lynn H.; Andrews, Larry S.; Zhang, Fagen] Dow Chem Co USA, Midland, MI 48674 USA. [Andrews, Larry S.] Rohm & Haas Co, Spring House, PA 19477 USA. [Bachman, Ammie N.] ExxonMobil Biomed Sci, Annandale, NJ USA. [Boogaard, Peter J.] Shell Int Bv, Shell Hlth, The Hague, Netherlands. [Cadet, Jean] CEA Grenoble, DSM INAC SCIB UMR E CEA UJF 3, F-38054 Grenoble 9, France. [Cadet, Jean] CEA Grenoble, FRE CNRS Les Acides Nucle 3200, F-38054 Grenoble 9, France. [Embry, Michelle R.; Kim, James H.] ILSI Hlth & Environm Sci Inst, Washington, DC USA. [Farmer, Peter B.] Univ Leicester, Dept Canc Studies & Mol Med, Bioctr, Leicester, Leics, England. [Farmer, Peter B.] DuPont Haskell Global Ctr Hlth Sci, Newark, DE USA. [Himmelstein, Matthew W.] DuPont Haskell Global Ctr Environm Sci, Newark, DE USA. [Jarabek, Annie M.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Martin, Elizabeth A.] AstraZeneca, Drug Safety & Metab, Macclesfield, Cheshire, England. [Mauthe, Robert J.] Pfizer Worldwide Res & Dev, Groton, CT USA. [Persaud, Rudranath] LOreal USA, Clark, NJ USA. [Preston, R. Julian] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Schoeny, Rita] US EPA, Off Water, Washington, DC 20460 USA. [Swenberg, James A.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC USA. [Williams, Gary M.] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA. [Zeiger, Errol] Errol Zeiger Consulting, Chapel Hill, NC USA. RP Embry, MR (reprint author), ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA. EM membry@hesiglobal.org OI Boogaard, Peter J./0000-0002-6964-6681; Cadet, Jean/0000-0003-2594-9485 FU ILSI Health and Environmental Sciences Institute FX This publication was authored collectively by the HESI Biological Significance of DNA Adducts Project Committee, whose work was funded by ILSI Health and Environmental Sciences Institute, a non-profit institution which collects funding from member companies to support projects. The employment affiliation of the authors is shown on the cover page. These individuals had the sole responsibility for the writing and content of the paper. The individual authors worked as professionals in preparing the article and not as agents of their employers. Three of the co-authors (PBF, JAS and GMW) are affiliated with universities, one co-author (EZ) is an independent consultant providing services to public and private organizations, four of the co-authors (AMJ, RJP, RS, JC) are affiliated with government agencies, two co-authors (MRE, JHK) are affiliated with a non-profit organization funded largely by industry membership, and ten of the coauthors (LHP, LSA, ANB, PJB, MWH, EAM, RJM, RP, JS and FZ) are employed by or retired from private corporations. Government and academic committee participants and the consultant, were reimbursed for travel expenses to attend committee meetings and did not receive any other compensation. It is noted that some employers produce and market one or more of the case study agents and/or similar agents; other authors are involved in developing regulations for these and/or similar agents; and other authors are independent consultants to industry and government on these and/or similar agents. NR 383 TC 6 Z9 6 U1 3 U2 18 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD APR PY 2014 VL 44 IS 4 BP 348 EP 391 DI 10.3109/10408444.2013.873768 PG 44 WC Toxicology SC Toxicology GA AG2AM UT WOS:000335217300002 PM 24494825 ER PT J AU Lin, YS Ginsberg, G Lin, JW Sonawane, B AF Lin, Yu-Sheng Ginsberg, Gary Lin, Jou-Wei Sonawane, Babasaheb TI Mercury exposure and omega-3 fatty acid intake in relation to renal function in the US population SO INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH LA English DT Article DE Mercury; Renal function; Omega-3 fatty acids ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; INORGANIC MERCURY; FISH CONSUMPTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; METHYL MERCURY; UNITED-STATES; METHYLMERCURY; HYPERTENSION AB It remains unclear whether exposure to low-level mercury (Hg) is associated with impaired renal function, and whether omega-3 fatty acid (FA) intake could affect the association of interest. The current study examined the association of blood Hg and omega-3 FAs with renal function using data from 1046 subjects aged 40 or above from the 2003-2004 National Health and Nutrition Examination Survey. Kidney function was assessed by estimated glomerular filtration rate (eGFR) and occurrence of albuminuria. Logistic regression analyses were applied to assess the association of interest with confounding variable adjustment. The analyses indicated that blood Hg was associated with reduced eGFR (<60 mL/min/1.73 m(2)) in a dose-response fashion (p <0.05). The association was particularly apparent with adjustment for blood omega-3 FA levels. The adjusted odds ratio for having reduced eGFR was 2.94 (95% confidence interval = 1.04-8.33) in the highest tertile of blood Hg as compared with the lowest tertile. There was no significant association between Hg exposure and albuminuria. In summary, this study demonstrates that Hg exposure is associated with increased odds of having lower GFR in the US population aged 40 or above. A statistical association with albuminuria was not apparent. We also observed that omega-3 FA intake may play a preventive role in Hg-induced nephrotoxicity. Additional studies are warranted to determine the sources, exposure routes, and forms of Hg most responsible for observed associations. Published by Elsevier GmbH. C1 [Lin, Yu-Sheng; Sonawane, Babasaheb] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. [Ginsberg, Gary] Connecticut Dept Publ Hlth, Hartford, CT 06134 USA. [Lin, Jou-Wei] Natl Taiwan Univ Hosp, Yun Lin Branch, Dou Liou City 640, Taiwan. RP Lin, YS (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. EM Lin.Yu-Sheng@epa.gov NR 54 TC 3 Z9 3 U1 1 U2 18 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1438-4639 EI 1618-131X J9 INT J HYG ENVIR HEAL JI Int. J. Hyg. Environ. Health. PD APR-MAY PY 2014 VL 217 IS 4-5 BP 465 EP 472 DI 10.1016/j.ijheh.2013.09.004 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AG0NZ UT WOS:000335113500006 PM 24189320 ER PT J AU Rius, M Darling, JA AF Rius, Marc Darling, John A. TI How important is intraspecific genetic admixture to the success of colonising populations? SO TRENDS IN ECOLOGY & EVOLUTION LA English DT Review ID MARINE BIOLOGICAL INVASIONS; MULTIPLE INTRODUCTIONS; RANGE EXPANSION; TRANSGRESSIVE SEGREGATION; PROPAGULE PRESSURE; HYBRID VIGOR; INBREEDING DEPRESSION; EVOLUTIONARY ECOLOGY; COLONIZATION SUCCESS; PAIRWISE COMPARISONS AB Genetic admixture of divergent intraspecific lineages is increasingly suspected to have an important role in the success of colonising populations. However, admixture is not a universally beneficial genetic phenomenon. Selection is typically expected to favour locally adapted genotypes and can act against admixed individuals, suggesting that there are some conditions under which admixture will have negative impacts on population fitness. Therefore, it remains unclear how often admixture acts as a true driver of colonisation success. Here, we review the population consequences of admixture and discuss its costs and benefits across a broad spectrum of ecological contexts. We critically evaluate the evidence for a causal role of admixture in successful colonisation, and consider that role more generally in driving population range expansion. C1 [Rius, Marc] Univ Southampton, Natl Oceanog Ctr, Southampton SO14 3ZH, Hants, England. [Darling, John A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Rius, M (reprint author), Univ Southampton, Natl Oceanog Ctr, European Way, Southampton SO14 3ZH, Hants, England. EM M.Rius@soton.ac.uk RI Rius, Marc/C-5088-2011 OI Rius, Marc/0000-0002-2195-6605 NR 99 TC 89 Z9 89 U1 24 U2 159 PU ELSEVIER SCIENCE LONDON PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0169-5347 J9 TRENDS ECOL EVOL JI Trends Ecol. Evol. PD APR PY 2014 VL 29 IS 4 BP 233 EP 242 DI 10.1016/j.tree.2014.02.003 PG 10 WC Ecology; Evolutionary Biology; Genetics & Heredity SC Environmental Sciences & Ecology; Evolutionary Biology; Genetics & Heredity GA AG5VZ UT WOS:000335488100008 PM 24636862 ER PT J AU Gawande, MB Shelke, SN Zboril, R Varma, RS AF Gawande, Manoj B. Shelke, Sharad N. Zboril, Radek Varma, Rajender S. TI Microwave-Assisted Chemistry: Synthetic Applications for Rapid Assembly of Nanomaterials and Organics SO ACCOUNTS OF CHEMICAL RESEARCH LA English DT Review ID ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; GREEN SYNTHESIS; AQUEOUS-MEDIUM; METAL NANOPARTICLES; GOLD NANOPARTICLES; CARBONYL-COMPOUNDS; CLICK CHEMISTRY; SOLVENT-FREE; AMINO-ACIDS AB The magic of microwave (MW) heating technique, termed the Bunsen burner of the 21st century, has emerged as a valuable alternative in the synthesis of organic compounds, polymers, inorganic materials, and nanomaterials. Important innovations in MW-assisted chemistry now enable chemists to prepare catalytic materials or nanomaterials and desired organic molecules, selectively, in almost quantitative yields and with greater precision than using conventional heating. By controlling the specific MW parameters (temperature, pressure, and ramping of temperature) and choice of solvents, researchers can now move into the next generation of advanced nanomaterial design and development. Microwave-assisted chemical reactions are now well-established practices in the laboratory setting although some controversy lingers as to how MW irradiation is able to enhance or influence the outcome of chemical reactions. Much of the discussion has focused on whether the observed effects can, in all instances, be rationalized by purely thermal Arrhenius-based phenomena (thermal microwave effects), that is, the importance of the rapid heating and high bulk reaction temperatures that are achievable using MW dielectric heating in sealed reaction vessels, or whether these observations can be explained by so-called "nonthermal" or "specific microwave" effects. In recent years, innovative and significant advances have occurred in MW hardware development to help delineate MW effects, especially the use of silicon carbide (SiC) reaction vessels and the accurate measurement of temperature using fiber optic (FO) temperature probes. SiC reactors appear to be good alternatives to MW transparent borosilicate glass, because of their high microwave absorptivity, and as such they serve as valuable tools to demystify the claimed magical MW effects. This enables one to evaluate the influence of the electromagnetic field on the specific chemical reactions, under truly identical conventional heating conditions, wherein temperature is measured accurately by fiber optic (FO) probe. This Account describes the current status of MW-assisted synthesis highlighting the introduction of various prototypes of equipment, classes of organic reactions pursued using nanomaterials, and the synthesis of unique and multifunctional nanomaterials; the ensuing nanomaterials possess zero-dimensional to three-dimensional shapes, such as spherical, hexagonal, nanoprisms, star shapes, and nanorods. The synthesis of well-defined nanomaterials and nanocatalysts is an integral part of nanotechnology and catalysis science, because it is imperative to control their size, shape, and compositional engineering for unique deployment in the field of nanocatalysis and organic synthesis. MW-assisted methods have been employed for the convenient and reproducible synthesis of well-defined noble and transition core-shell metallic nanoparticles with tunable shell thicknesses. Some of the distinctive attributes of MW-selective heating in the synthesis and applications of magnetic nanocatalysts in organic synthesis under benign reaction conditions are highlighted. Sustainable nanomaterials and their applications in benign media are an ideal blend for the development of greener methodologies in organic synthesis; MW heating provides superb value to the overall sustainable process development via process intensification including the flow systems. C1 [Gawande, Manoj B.; Zboril, Radek] Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Shelke, Sharad N.] SSGM Coll, Dept Chem, Kopargaon 423601, MH, India. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Gawande, MB (reprint author), Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Slechtitelu 11, Olomouc 78371, Czech Republic. EM manoj.gawande@upol.cz; Varma.Rajender@epa.gov RI Zboril, Radek/F-5153-2015; OI Zboril, Radek/0000-0002-3147-2196 FU Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.05/2.1.00/03.0058, CZ.1.07/2.3.00/30.0041] FX The authors gratefully acknowledge the support by the Operational Program Research and Development for Innovations - European Regional Development Fund (project CZ.1.05/2.1.00/03.0058), by the Operational Program Education for competitiveness - European Social Fund (project CZ.1.07/2.3.00/30.0041) of the Ministry of Education, Youth and Sports of the Czech Republic. NR 73 TC 115 Z9 116 U1 47 U2 370 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0001-4842 EI 1520-4898 J9 ACCOUNTS CHEM RES JI Accounts Chem. Res. PD APR PY 2014 VL 47 IS 4 BP 1338 EP 1348 DI 10.1021/ar400309b PG 11 WC Chemistry, Multidisciplinary SC Chemistry GA AF4CE UT WOS:000334658200036 PM 24666323 ER PT J AU Senkayi, SN Sattler, ML Rowe, N Chen, VCP AF Senkayi, Sala N. Sattler, Melanie L. Rowe, Nancy Chen, Victoria C. P. TI Investigation of an association between childhood leukemia incidences and airports in Texas SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Airports; emissions; benzene; childhood leukemia; geographic information systems ID HYDROCARBON EMISSIONS; PRENATAL ORIGIN; PUBLIC-HEALTH; BENZENE; EXPOSURE; RISK; POPULATION; ESCALE; CANCER; SFCE AB As worldwide demand for air travel increases, emissions from airports will likely also increase. Airport emissions pose a concern due to lack of information about their quantity and impacts on human health and the environment. This research aimed to address the question of whether there is an association between childhood leukemia cases and airport emissions in Texas. Rather than looking at the impacts of a single airport on the surrounding community, this study looks at all airports in the state of Texas, and 2 134 incidences of childhood leukemia (children age 9 and under) state-wide over a 10-year period. The distance to airports of block groups with standardized incidence ratios > 100 for childhood leukemia was found to be shorter than the distance to airports for block groups with standardized incidence ratios < 100, to a 98% level of confidence. A Poisson regression model was developed to estimate incidences of childhood leukemia, based on county-wide benzene emissions. Benzene emissions from airports were found to be a statistically significant predictor variable. The two analyses provide evidence of an association between airports and incidences of childhood leukemia in Texas. C1 [Senkayi, Sala N.] US EPA, Dallas, TX 75202 USA. [Sattler, Melanie L.] Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA. [Rowe, Nancy] Univ Texas Arlington, Off Informat Technol, Arlington, TX 76019 USA. [Chen, Victoria C. P.] Univ Texas Arlington, Dept Ind & Mfg Syst Engn, Arlington, TX 76019 USA. RP Senkayi, SN (reprint author), US EPA, Reg 6,1445 Ross Ave,Suite 1200,6WQ, Dallas, TX 75202 USA. EM senkayi.sala@epa.gov RI Sattler, Melanie/F-3734-2015 FU Regional Research Partnership Program grant via the Office of Research and Development FX The authors would like to thank the Texas Department of State Health Services for providing the cancer data and their help in calculating the expected values. Special thanks go to Joshua Been (UTA) for his GIS advice, as well as to the National Center for Environmental Assessment, Research Triangle Park, Environmental Protection Agency Region 6 (EPA R6) GIS Group, and the Regional Research Partnership Program grant via the Office of Research and Development. NR 51 TC 2 Z9 2 U1 0 U2 5 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD APR PY 2014 VL 5 IS 2 BP 189 EP 195 DI 10.5094/APR.2014.023 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AF1SB UT WOS:000334492600003 ER PT J AU Gonzalez, MA AF Gonzalez, Michael A. TI Environmental Protection for Sustainability SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Editorial Material C1 US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Gonzalez, MA (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM gonzalez.michael@epa.gov NR 0 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 673 EP 674 DI 10.1007/s10098-014-0748-1 PG 2 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100001 ER PT J AU Glaser, JA AF Glaser, John A. TI Green money laundering SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT News Item C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Glaser, JA (reprint author), US EPA, Natl Risk Management Res Lab, 26 W King Dr, Cincinnati, OH 45268 USA. EM Glaser.John@epa.gov NR 7 TC 1 Z9 1 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 675 EP 680 DI 10.1007/s10098-014-0751-6 PG 6 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100002 ER PT J AU Bare, JC AF Bare, Jane C. TI Development of impact assessment methodologies for environmental sustainability SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Life cycle impact assessment; Life cycle assessment; Sustainability; LCA; LCIA; Impact assessment ID LIFE-CYCLE-ASSESSMENT; LAND-USE IMPACTS; DECISION-ANALYTIC FRAMEWORK; ECOSYSTEM SERVICES; NATURAL-ENVIRONMENT; EVALUATIVE FATE; ASSESSMENT LCA; UNITED-STATES; FUEL ETHANOL; END-POINTS AB Despite years of discussion on the merits of sustainability, there is still no consensus on how to determine if environmental sustainability is achieved or even if progress is made. The Brundtland Commission statement that sustainability "meets the needs of the present without compromising the ability of future generations to meet their own needs (World Commission on Environment and Development, Our common future, Oxford University Press, New York, 1987)" establishes the long-term focus of sustainability goals. Impact categories, such as land and water use, that can cause large spatial and long-temporal scale impacts are important for sustainability assessments, and may require detailed spatial analysis to capture all the important input parameters. Environmental sustainability impact assessments can use life cycle impact assessment methodologies, but can also be supplemented with impact assessments conducted from a variety of perspectives. Having this flexibility of perspective can allow more detailed site-specific assessments that may represent unsustainable situations. While it is necessary to provide decision support with a comprehensive assessment, aggregation of impact categories has the disadvantage of obscuring the individual vulnerabilities of each impact category, which can be critically important to the overall sustainability picture. An outline of a sustainability assessment case study focused on biomass-based alternatives required under the renewable fuel standard will be provided to demonstrate a more comprehensive view of sustainability. C1 US EPA, Cincinnati, OH 45268 USA. RP Bare, JC (reprint author), US EPA, Cincinnati, OH 45268 USA. EM bare.jane@epa.gov NR 107 TC 21 Z9 21 U1 9 U2 39 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 681 EP 690 DI 10.1007/s10098-013-0685-4 PG 10 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100003 ER PT J AU Fiksel, J Bruins, R Gatchett, A Gilliland, A ten Brink, M AF Fiksel, Joseph Bruins, Randy Gatchett, Annette Gilliland, Alice ten Brink, Marilyn TI The triple value model: a systems approach to sustainable solutions SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Sustainability; Systems thinking; Triple value model; Integrated assessment ID MANAGEMENT AB The unintended environmental impacts of economic development threaten the continued availability of ecosystem services that are critical to human well-being. An integrated systems approach is needed to characterize sustainability problems and evaluate potential solutions. The Triple Value Model is an innovative framework that depicts the dynamic linkages and resource flows among industrial, societal, and environmental systems. The U.S. EPA has begun using this model to support transdisciplinary research projects that focus upon water resources, communities, and other broad sustainability themes. One recent application addresses opportunities for mitigation of nutrient impairment in the Narragansett Bay watershed, and has produced a policy simulation tool that enables evaluation of alternative sustainable solutions. C1 [Fiksel, Joseph; Bruins, Randy; Gatchett, Annette; Gilliland, Alice; ten Brink, Marilyn] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Fiksel, Joseph] Ohio State Univ, Ctr Resilience, Columbus, OH 43210 USA. RP Fiksel, J (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA. EM fiksel.2@osu.edu NR 24 TC 14 Z9 15 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 691 EP 702 DI 10.1007/s10098-013-0696-1 PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100004 ER PT J AU Ruiz-Mercado, GJ Gonzalez, MA Smith, RL AF Ruiz-Mercado, Gerardo J. Gonzalez, Michael A. Smith, Raymond L. TI Expanding GREENSCOPE beyond the gate: a green chemistry and life cycle perspective SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE GREENSCOPE; Sustainability assessment; Green chemistry; Life cycle assessment; Process design ID CHEMICAL-PROCESS DESIGN; SUSTAINABILITY INDICATORS; DECISION-MAKING; SYSTEMS; METHODOLOGY; UNCERTAINTY; FRAMEWORK AB Industrial processes, particularly those within the chemical industry, contribute products and services to improve and increase society's quality of life. However, the transformation of raw materials into their respective final goods involves the consumption of mass and energy and the possible generation of by-products and releases. To address these issues, the new approach for chemical processing is focused on sustainable production: minimize raw material consumption and energy loads, minimize/eliminate releases, and increase the economic feasibility of the process. To evaluate these advances, a sustainability assessment methodology, GREENSCOPE, has been developed into a tool to evaluate and assist in the synthesis and design of chemical processes. New process sustainability indicators have been proposed based on input/output process data, and the base-case ratio approach is implemented to predict process changes from known process performance data and design relationships. In addition, a discussion regarding the implications of using sustainability evaluations beyond the process boundaries, applying the principles of green chemistry in all steps of chemical process development, and a description of their benefits to the life cycle inventory and the subsequent life cycle assessment is included. Finally, a new methodology approach to integrate GREENSCOPE into a life cycle inventory to develop sustainable systems is introduced. C1 [Ruiz-Mercado, Gerardo J.; Gonzalez, Michael A.; Smith, Raymond L.] US EPA, Natl Risk Management Res Lab, Off Res Dev, Cincinnati, OH 45268 USA. RP Ruiz-Mercado, GJ (reprint author), US EPA, Natl Risk Management Res Lab, Off Res Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM ruiz-mercado.gerardo@epa.gov FU U.S. Department of Energy; EPA FX This project was supported in part by an appointment of Dr. Ruiz-Mercado to the Research Participation Program for the EPA, Office of Research and Development administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and EPA. NR 63 TC 7 Z9 7 U1 3 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 703 EP 717 DI 10.1007/s10098-012-0533-y PG 15 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100005 ER PT J AU Ingwersen, WW Garmestani, AS Gonzalez, MA Templeton, JJ AF Ingwersen, Wesley W. Garmestani, Ahjond S. Gonzalez, Michael A. Templeton, Joshua J. TI A systems perspective on responses to climate change SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Climate mitigation; Adaptation strategies; Systems theory; Life cycle thinking; Risk-benefit analysis ID CARBON; THRESHOLDS; CAPACITY; POLICY AB The science of climate change integrates many scientific fields to explain and predict the complex effects of greenhouse gas concentrations on the planet's energy balance, weather patterns, and ecosystems as well as economic and social systems. A changing climate requires responses to curtail climate forcing as well as to adapt to impending changes. Responses can be categorized into mitigation and adaptation-the former involving efforts to reduce greenhouse gas emissions, and the latter involving strategies to adapt to predicted changes. These responses must be of significant scale and extent to be effective, but significant tradeoffs and unintended effects must be avoided. Concepts and science based on systems theory are needed to reduce the risk of unintended consequences from potential responses to climate change. We propose expanding on a conventional risk-based approach to include additional ways of analyzing risks and benefits, such as considering potential cascading ecological effects, full life cycle environmental impacts, and unintended consequences, as well as considering possible co-benefits of responses. Selected responses to climate change are assessed with this expanded set of criteria, and we find that mitigation measures that involve reducing emissions of greenhouse gases that provide corollary benefits are likely to have less negative indirect impacts than large-scale solar radiation management approaches. However, because effects of climate change are unavoidable in the near and medium-term, adaptation strategies that will make societies more resilient in the face of impending change are essential to sustainability. C1 [Ingwersen, Wesley W.; Garmestani, Ahjond S.; Gonzalez, Michael A.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Templeton, Joshua J.] US Embassy Peru, US Agcy Int Dev, Lima, Peru. RP Ingwersen, WW (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM ingwersen.wesley@epa.gov OI Ingwersen, Wesley/0000-0002-9614-701X NR 61 TC 11 Z9 11 U1 2 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 719 EP 730 DI 10.1007/s10098-012-0577-z PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100006 ER PT J AU Garmestani, AS AF Garmestani, Ahjond S. TI Sustainability science: accounting for nonlinear dynamics in policy and social-ecological systems SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Sustainability; Resilience; Adaptive management; Adaptive governance; Panarchy; Policy ID ADAPTIVE COMANAGEMENT; ENVIRONMENTAL-POLICY; MANAGEMENT; RESILIENCE; CONSERVATION; UNCERTAINTY; FRAMEWORK; PANACEAS; TRANSITIONS; GOVERNANCE AB Resilience is an emergent property of complex systems. Understanding resilience is critical for sustainability science, as linked social-ecological systems and the policy process that governs them have the capacity for nonlinear dynamics. The possibility of nonlinear change in these systems means that there is an inherent degree of uncertainty in social-ecological systems and the policy process. Abrupt, nonlinear change often results in social and/or ecological surprises that create tremendous challenges for environmental management. Thus, it is necessary to improve environmental management via a suite of mechanisms that have the capacity for adaptation. This paper suggests how we can move closer to achieving this goal through an overarching focus, including reformed and new law, adaptive management and adaptive governance, scenario planning, and leading indicators. C1 US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Garmestani, AS (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM garmestani.ahjond@epa.gov NR 58 TC 6 Z9 6 U1 6 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 731 EP 738 DI 10.1007/s10098-013-0682-7 PG 8 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100007 ER PT J AU Smith, RL Ruiz-Mercado, GJ AF Smith, Raymond L. Ruiz-Mercado, Gerardo J. TI A method for decision making using sustainability indicators SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Decision making; Weights; Multiobjective; Marginal rates of substitution; Singular value decomposition; Sustainability indicators; GREENSCOPE AB Calculations aimed at representing the thought process of decision makers are common within multiobjective decision support tools. These calculations that mathematically describe preferences most often use weighting factors for each desire or objective to combine various utility scores onto a single scale to allow a ranking of alternatives. However, seldom are the tradeoffs implied in creating a single scale for multiple objectives described explicitly. This paper illustrates how choices for combining utility scores are in fact a statement of equivalence between the weighted utility scores of these objectives, even if the choice of weighting factors was intended to be value free or "equal weighting." In addition, relationships between objectives, perhaps developed by stakeholders, can be rewritten as a series of equations (i.e., relationships) for the weighting factors, where it should be noted that seldom will stakeholders provide a set of relationships that exactly match the number of unknowns. Depending on the number of relationships specified, the weighting factors can be underdetermined, unique, or overdetermined. Calculations using the singular value decomposition method can be used as a general method to determine the weighting factors for each of these situations, allowing for explicit representations of the implied tradeoffs for decision makers. Finally, a simple but powerful method for calculating total utility using marginal rates of substitution between utility scores rather than weighting factors is presented. In addition to using marginal rates of substitution, the calculation of utility can be done with (process) attribute values or using EPA's GREENSCOPE tool sustainability indicator scores. Utility calculations based on these more intuitive factors (marginal rates of substitution, attribute values, and/or GREENSCOPE indicator scores) can then be used to evaluate various alternatives. The decision maker can see the effects of changing the marginal rates of substitution (i.e., utility tradeoffs) and attribute (i.e., design or operating parameter) values or GREENSCOPE indicator scores for alternatives. While an example from chemical production for terephthalic acid is presented, the methods shown are generally applicable. C1 [Smith, Raymond L.; Ruiz-Mercado, Gerardo J.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Smith, RL (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. EM smith.raymond@epa.gov NR 14 TC 11 Z9 11 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 749 EP 755 DI 10.1007/s10098-013-0684-5 PG 7 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100009 ER PT J AU Meyer, DE Upadhyayula, VKK AF Meyer, David E. Upadhyayula, Venkata K. K. TI The use of life cycle tools to support decision making for sustainable nanotechnologies SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Nanotechnology; Sustainability; Life cycle assessment (LCA); Life cycle risk assessment (LCRA); Life cycle costing (LCC); Social life cycle assessment (SLCA); Life cycle sustainability assessment (LCSA) ID RISK-ASSESSMENT; ENGINEERED NANOMATERIALS; POLICY-MAKING; ENVIRONMENTAL ASSESSMENT; UNCERTAINTY ANALYSIS; MANAGEMENT; NANOPARTICLES; IMPACT; OPPORTUNITIES; NANOPRODUCTS AB Nanotechnology is a broad-impact technology with applications ranging from materials and electronics to analytical methods and metrology. The many benefits that can be realized through the utilization of nanotechnology are intended to lead to an improved quality of life. However, numerous concerns have been expressed regarding the unchecked growth of nanotechnology and the unforeseen consequences it may bring. To address the concerns, nanotechnology must be examined under the microscope of sustainability. This work applies the life cycle perspective to provide an understanding of the challenges facing the development of sustainable nanotechnology. A discussion of the holistic tools used to assess the components of sustainability serves as the basis to examine how a harmony between policy and product development can be maintained using decision making for sustainability. This harmony will be most readily achieved using an enhanced risk management strategy for sustainability that combines sustainability assessment with sustainable chemical design. C1 [Meyer, David E.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Upadhyayula, Venkata K. K.] ORISE, Oak Ridge, TN 37831 USA. RP Meyer, DE (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM meyer.david@epa.gov FU US Environmental Protection Agency through its Office of Research and Development; National Risk Management Research Laboratory; US Department of Energy [DW 89- 92298301-0]; US Environmental Protection Agency [DW 89- 92298301-0] FX The US Environmental Protection Agency through its Office of Research and Development funded the research described here. It has not been subjected to Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. This research was supported in part by an appointment of Venkata K. K. Upadhyayula in the Postdoctoral Research Program at the National Risk Management Research Laboratory, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW 89- 92298301-0 between the US Department of Energy and the US Environmental Protection Agency. NR 103 TC 14 Z9 14 U1 6 U2 43 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 757 EP 772 DI 10.1007/s10098-013-0686-3 PG 16 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100010 ER PT J AU Eason, T Garmestani, AS Cabezas, H AF Eason, Tarsha Garmestani, Ahjond S. Cabezas, Heriberto TI Managing for resilience: early detection of regime shifts in complex systems SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Regime shift; Leading indicator; Fisher information; Resilience; Environmental management ID ECOLOGICAL COMMUNITY THRESHOLDS; FISHER INFORMATION; NORTH PACIFIC; CRITICAL TRANSITIONS; CLIMATE VARIABILITY; LEADING INDICATOR; SUSTAINABILITY; ECOSYSTEMS; MANAGEMENT; OCEAN AB The broad implications of catastrophic regime shifts have prompted the need to find methods that are not only able to detect regime shifts but more importantly, identify them before they occur. Rising variance, skewness, kurtosis, and critical slowing down have all been proposed as indicators of impending regime shifts. However, these approaches typically do not signal a shift until it is well underway. Further, they have primarily been used to evaluate simple systems; hence, additional work is needed to adapt these methods, if possible, to real systems which typically are complex and multivariate. Fisher information is a key method in information theory and affords the ability to characterize the dynamic behavior of systems. In this work, Fisher information is compared to traditional indicators through the assessment of model and real systems and identified as a leading indicator of impending regime shifts. Evidenced by the great deal of activity in this research area, it is understood that such work could lead to better methods for detecting and managing systems that are of significant importance to humans. Thus, we believe the results of this work offer great promise for resilience science and sustainability. C1 [Eason, Tarsha; Garmestani, Ahjond S.; Cabezas, Heriberto] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Eason, T (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS483, Cincinnati, OH 45268 USA. EM eason.tarsha@epa.gov NR 51 TC 11 Z9 11 U1 1 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD APR PY 2014 VL 16 IS 4 SI SI BP 773 EP 783 DI 10.1007/s10098-013-0687-2 PG 11 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AF4KF UT WOS:000334680100011 ER PT J AU Kriegler, E Weyant, JP Blanford, GJ Krey, V Clarke, L Edmonds, J Fawcett, A Luderer, G Riahi, K Richels, R Rose, SK Tavoni, M van Vuuren, DP AF Kriegler, Elmar Weyant, John P. Blanford, Geoffrey J. Krey, Volker Clarke, Leon Edmonds, Jae Fawcett, Allen Luderer, Gunnar Riahi, Keywan Richels, Richard Rose, Steven K. Tavoni, Massimo van Vuuren, Detlef P. TI The role of technology for achieving climate policy objectives: overview of the EMF 27 study on global technology and climate policy strategies SO CLIMATIC CHANGE LA English DT Article ID ENERGY; MITIGATION; TARGETS; COSTS AB This article presents the synthesis of results from the Stanford Energy Modeling Forum Study 27, an inter-comparison of 18 energy-economy and integrated assessment models. The study investigated the importance of individual mitigation options such as energy intensity improvements, carbon capture and storage (CCS), nuclear power, solar and wind power and bioenergy for climate mitigation. Limiting the atmospheric greenhouse gas concentration to 450 or 550 ppm CO2 equivalent by 2100 would require a decarbonization of the global energy system in the 21(st) century. Robust characteristics of the energy transformation are increased energy intensity improvements and the electrification of energy end use coupled with a fast decarbonization of the electricity sector. Non-electric energy end use is hardest to decarbonize, particularly in the transport sector. Technology is a key element of climate mitigation. Versatile technologies such as CCS and bioenergy are found to be most important, due in part to their combined ability to produce negative emissions. The importance of individual low-carbon electricity technologies is more limited due to the many alternatives in the sector. The scale of the energy transformation is larger for the 450 ppm than for the 550 ppm CO(2)e target. As a result, the achievability and the costs of the 450 ppm target are more sensitive to variations in technology availability. C1 [Kriegler, Elmar; Luderer, Gunnar] Potsdam Inst Climate Impact Res, D-14473 Potsdam, Germany. [Weyant, John P.] Stanford Univ, Palo Alto, CA 94304 USA. [Blanford, Geoffrey J.; Richels, Richard; Rose, Steven K.] Elect Power Res Inst, Energy & Environm Anal Res Grp, Washington, DC USA. [Clarke, Leon; Edmonds, Jae] Univ Maryland, Joint Global Change Res Inst, Pacific NW Natl Lab, College Pk, MD 20742 USA. [Fawcett, Allen] US EPA, Washington, DC 20460 USA. [Krey, Volker; Riahi, Keywan] Int Inst Appl Syst Anal, A-2361 Laxenburg, Austria. [Tavoni, Massimo] FEEM, Milan, Italy. [Tavoni, Massimo] CMCC, Milan, Italy. [van Vuuren, Detlef P.] PBL Netherlands Environm Assessment Agcy, Bilthoven, Netherlands. [van Vuuren, Detlef P.] Univ Utrecht, Dept Geosci, Utrecht, Netherlands. RP Kriegler, E (reprint author), Potsdam Inst Climate Impact Res, Telegrafenberg A31, D-14473 Potsdam, Germany. EM kriegler@pik-potsdam.de RI Luderer, Gunnar/G-2967-2012; van Vuuren, Detlef/A-4764-2009; Kriegler, Elmar/I-3048-2016; Riahi, Keywan/B-6426-2011 OI van Vuuren, Detlef/0000-0003-0398-2831; Kriegler, Elmar/0000-0002-3307-2647; Riahi, Keywan/0000-0001-7193-3498 FU Office of Science of the U.S. Department of Energy [DE-AC05-76RL01830]; European Commission [282846] FX Jae Edmonds and Leon Clarke are grateful for research support provided by the Integrated Assessment Research Program in the Office of Science of the U.S. Department of Energy under Contract No. DE-AC05-76RL01830. Results reported for the GCAM model used Evergreen computing resources at the Pacific Northwest National Laboratory's Joint Global Change Research Institute at the University of Maryland in College Park, which is supported by the Integrated Assessment Research Program in the Office of Science of the U.S. Department of Energy. The views and opinions expressed in this paper are those of the authors alone.; The contribution of Elmar Kriegler, Volker Krey, Gunnar Luderer, Keywan Riahi, Massimo Tavoni and Detlev van Vuuren to this research was supported by funding from the European Commission's Seventh Framework Programme under the LIMITS project (grant agreement no. 282846). NR 17 TC 92 Z9 93 U1 7 U2 50 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD APR PY 2014 VL 123 IS 3-4 SI SI BP 353 EP 367 DI 10.1007/s10584-013-0953-7 PG 15 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AF0OW UT WOS:000334414900002 ER PT J AU Allen, ST Brooks, JR Keim, RF Bond, BJ McDonnell, JJ AF Allen, S. T. Brooks, J. R. Keim, R. F. Bond, B. J. McDonnell, J. J. TI The role of pre- event canopy storage in throughfall and stemflow by using isotopic tracers SO ECOHYDROLOGY LA English DT Article DE canopy storage; stable isotope tracers; rainfall interception; spatial heterogeneity; temporal stability ID SPATIAL VARIABILITY; RAIN-FOREST; SOIL-WATER; WOODED ECOSYSTEMS; INTERCEPTION LOSS; STABLE-ISOTOPES; PATTERNS; O-18; TREE; FLOW AB Stable isotopes can be a valuable tool for tracing the redistribution, storage, and evaporation of water associated with canopy interception of rainfall. Isotopic differences between throughfall and rainfall have been attributed to three mechanisms: evaporative fractionation, isotopic exchange with ambient vapor, and temporal redistribution. We demonstrate the potential importance of a fourth mechanism: rainfall mixing with water retained within the canopy (in bark, epiphytes, etc.) from prior rain events. Amount and isotopic composition (O-18 and H-2) of rainfall and throughfall were measured over a 3-month period in a Douglas-fir forest in the Cascade Range of Oregon, USA. The range of spatial variability of throughfall isotopic composition exceeded the differences between event-mean isotopic compositions of rainfall and throughfall. Inter-event isotopic variation of precipitation was high and correlated with the isotopic deviation of throughfall from rainfall, likely related to a high canopy/bark storage capacity storage bridging events. Both spatial variability of throughfall isotopic composition and throughfall-precipitation isotopic differences appear to have been controlled by the temporally varying influence of residual precipitation from previous events. Therefore, isotopic heterogeneity could indicate local storage characteristics and the partitioning of flow-paths within the canopy. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Allen, S. T.; Keim, R. F.] Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [Brooks, J. R.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA. [Bond, B. J.] Oregon State Univ, Forest Ecosyst & Soc Dept, Corvallis, OR 97333 USA. [McDonnell, J. J.] Univ Saskatchewan, Global Inst Water Secur, Saskatoon, SK, Canada. RP Allen, ST (reprint author), Louisiana State Univ, 227 Renewable Nat Resources Bldg, Baton Rouge, LA 70803 USA. EM Salle48@lsu.edu OI Brooks, Renee/0000-0002-5008-9774 FU H. J. Andrews Experimental Forest research program - National Science Foundation's Long-Term Ecological Research Program [DEB 08-23380]; US Forest Service Pacific Northwest Research Station; Oregon State University FX Data, facilities and financial support were provided by the H. J. Andrews Experimental Forest research program, funded by the National Science Foundation's Long-Term Ecological Research Program (DEB 08-23380), US Forest Service Pacific Northwest Research Station, and Oregon State University. This manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and it has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. We thank Dr. Delphis Levia and Dr. Robert Ozretich for their reviews of this manuscript. We also thank Allison Danner, Tina Garland, and Caroline Patrick for assistance in the lab and field. NR 54 TC 12 Z9 12 U1 3 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD APR PY 2014 VL 7 IS 2 BP 858 EP 868 DI 10.1002/eco.1408 PG 11 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AF4HC UT WOS:000334671600053 ER PT J AU Ghio, AJ Kummarapurugu, ST Tong, H Soukup, JM Dailey, LA Boykin, E Gilmour, MI Ingram, P Roggli, VL Goldstein, HL Reynolds, RL AF Ghio, Andrew J. Kummarapurugu, Suryanaren T. Tong, Haiyan Soukup, Joleen M. Dailey, Lisa A. Boykin, Elizabeth Gilmour, M. Ian Ingram, Peter Roggli, Victor L. Goldstein, Harland L. Reynolds, Richard L. TI Biological effects of desert dust in respiratory epithelial cells and a murine model SO INHALATION TOXICOLOGY LA English DT Article DE Air pollution; dust; inflammation mediators; particulate matter ID CHARACTERIZING MINERAL DUSTS; AMBIENT PARTICULATE MATTER; AIR-POLLUTION; STORM EVENTS; OXIDANT GENERATION; OXIDATIVE STRESS; DAILY MORTALITY; FINE PARTICLES; UNITED-STATES; SAHARAN DUST AB As a result of the challenge of recent dust storms to public health, we tested the postulate that desert dust collected in the southwestern United States imparts a biological effect in respiratory epithelial cells and an animal model. Two samples of surface sediment were collected from separate dust sources in northeastern Arizona. Analysis of the PM20 fraction demonstrated that the majority of both dust samples were quartz and clay minerals (total SiO2 of 52 and 57%). Using respiratory epithelial and monocytic cell lines, the two desert dusts increased oxidant generation, measured by Amplex Red fluorescence, along with carbon black (a control particle), silica, and NIST 1649 (an ambient air pollution particle). Cell oxidant generation was greatest following exposures to silica and the desert dusts. Similarly, changes in RNA for superoxide dismutase-1, heme oxygenase-1, and cyclooxygenase-2 were also greatest after silica and the desert dusts supporting an oxidative stress after cell exposure. Silica, desert dusts, and the ambient air pollution particle NIST 1649 demonstrated a capacity to activate the p38 and ERK1/2 pathways and release pro-inflammatory mediators. Mice, instilled with the same particles, showed the greatest lavage concentrations of pro-inflammatory mediators, neutro-phils, and lung injury following silica and desert dusts. We conclude that, comparable to other particles, desert dusts have a capacity to (1) influence oxidative stress and release of pro-inflammatory mediators in respiratory epithelial cells and (2) provoke an inflammatory injury in the lower respiratory tract of an animal model. The biological effects of desert dusts approximated those of silica. C1 [Ghio, Andrew J.; Kummarapurugu, Suryanaren T.; Tong, Haiyan; Soukup, Joleen M.; Dailey, Lisa A.; Boykin, Elizabeth; Gilmour, M. Ian] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Ingram, Peter; Roggli, Victor L.] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA. [Goldstein, Harland L.; Reynolds, Richard L.] US Geol Survey, Denver, CO 80225 USA. RP Ghio, AJ (reprint author), US EPA, HSF, Environm Publ Hlth Div, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27711 USA. EM ghio.andy@epa.gov FU US Geological Survey Climate and Land-Use Change Program FX We thank Jiang Xiao, G. Skipp, D. Fernandez, F. Luiszer for preparation and analyses of the desert dust samples, G. Breit for help with XRD interpretations, and D. Andrews and J. Richards for assistance with animal investigation and analyses of blood and lavage samples. Partial support was provided by the US Geological Survey Climate and Land-Use Change Program. NR 55 TC 9 Z9 9 U1 1 U2 16 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD APR PY 2014 VL 26 IS 5 BP 299 EP 309 DI 10.3109/08958378.2014.888109 PG 11 WC Toxicology SC Toxicology GA AF5HT UT WOS:000334745300005 PM 24669951 ER PT J AU Riedel, TE Zimmer-Faust, AG Thulsiraj, V Madi, T Hanley, KT Ebentier, DL Byappanahalli, M Layton, B Raith, M Boehm, AB Griffith, JF Holden, PA Shanks, OC Weisberg, SB Jay, JA AF Riedel, Timothy E. Zimmer-Faust, Amity G. Thulsiraj, Vanessa Madi, Tania Hanley, Kaitlyn T. Ebentier, Darcy L. Byappanahalli, Muruleedhara Layton, Blythe Raith, Meredith Boehm, Alexandria B. Griffith, John F. Holden, Patricia A. Shanks, Orin C. Weisberg, Stephen B. Jay, Jennifer A. TI Detection limits and cost comparisons of human- and gull-associated conventional and quantitative PCR assays in artificial and environmental waters SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE LOD; qPCR; Endpoint; Gull; HF183; Cost analysis ID REAL-TIME PCR; MICROBIAL SOURCE TRACKING; FECAL CONTAMINATION; CLINICAL-SAMPLES; GENETIC-MARKERS; QUANTIFICATION; DNA; INHIBITION; IDENTIFICATION; PERFORMANCE AB Some molecular methods for tracking fecal pollution in environmental waters have both PCR and quantitative PCR (qPCR) assays available for use. To assist managers in deciding whether to implement newer qPCR techniques in routine monitoring programs, we compared detection limits (LODs) and costs of PCR and qPCR assays with identical targets that are relevant to beach water quality assessment. For human-associated assays targeting Bacteroidales HF183 genetic marker, qPCR LODs were 70 times lower and there was no effect of target matrix (artificial freshwater, environmental creek water, and environmental marine water) on PCR or qPCR LODs. The PCR startup and annual costs were the lowest, while the per reaction cost was 62% lower than the Taqman based qPCR and 180% higher than the SYBR based qPCR. For gull-associated assays, there was no significant difference between PCR and qPCR LODs, target matrix did not effect PCR or qPCR LODs, and PCR startup, annual, and per reaction costs were lower. Upgrading to qPCR involves greater startup and annual costs, but this increase may be justified in the case of the human-associated assays with lower detection limits and reduced cost per sample. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Riedel, Timothy E.; Zimmer-Faust, Amity G.; Thulsiraj, Vanessa; Hanley, Kaitlyn T.; Ebentier, Darcy L.; Jay, Jennifer A.] Univ Calif Los Angeles, Dept Civil & Environm Engn, Los Angeles, CA 90095 USA. [Zimmer-Faust, Amity G.] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA. [Madi, Tania] Source Mol Corp, Miami, FL 33155 USA. [Byappanahalli, Muruleedhara] US Geol Survey, Great Lakes Sci Ctr, Lake Michigan Ecol Res Stn, Porter, IN 46304 USA. [Raith, Meredith; Griffith, John F.; Weisberg, Stephen B.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. [Holden, Patricia A.] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Holden, Patricia A.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA. [Shanks, Orin C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Riedel, TE (reprint author), UT Austin Coll Nat Sci, 103 W 24th St,PAI 3-04M,G2550, Austin, TX 78712 USA. EM triedel@utexas.edu RI Weisberg, Stephen/B-2477-2008; OI Weisberg, Stephen/0000-0002-0655-9425; Hanley, Kaitlyn/0000-0002-8252-4689 FU Clean Beach Initiative Grant from the California State Water Resources Control Board; Nicholas Endowment FX Funding for this study was through a Clean Beach Initiative Grant from the California State Water Resources Control Board. We would like to thank John Law and Sofi Peterson (participants of the UCLA High School Summer Research Program funded by the Nicholas Endowment) and Ben Tanimoto for their help with sample processing. We are grateful to Samuel Choi and the Orange County Sanitation District for providing us with primary influent sewage. Any use of trade, product or firm names is for descriptive purposes only and does not imply endorsement by the US Government. This article is Contribution XXXX of the USGS Great Lakes Science Center. NR 39 TC 3 Z9 3 U1 2 U2 25 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD APR 1 PY 2014 VL 136 BP 112 EP 120 DI 10.1016/j.jenvman.2014.01.029 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AF6JN UT WOS:000334821400014 PM 24583609 ER PT J AU Kaldy, JE AF Kaldy, James E. TI Effect of temperature and nutrient manipulations on eelgrass Zostera marina L. from the Pacific Northwest, USA SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE Chambers; Climate change; Factorial experiment; Nutrients; Temperature; Zostera marina ID WATER-COLUMN NITRATE; WASTING DISEASE; LABYRINTHULA-ZOSTERAE; MESOCOSM EXPERIMENTS; NITROGEN-METABOLISM; SEASONAL-VARIATIONS; AQUATIC VEGETATION; CLIMATE-CHANGE; SEAGRASS; ENRICHMENT AB Global climate change will impact the three dominate drivers of estuarine seagrass productivity, temperature, light and nutrients. The response of Pacific Northwest (PNW) Z. marina to interactive effects of temperature and nitrogen conditions was experimentally evaluated. Experimental manipulations were conducted hydroponically in acrylic chambers. Preliminary single factor experiments were conducted to evaluate physiological tolerances to temperature and nitrogen concentrations. Eelgrass exhibited a statistically significant linear increase in relative growth with increasing NH4 concentration (range from 5 to 1000 mu M); in contrast, there was no relationship between relative growth rate and increasing NO3 concentration. After 14 d there were no indications of plant mortality associated with NH4 or NO3. Leaf growth metrics exhibited strong statistically significant linear relationships with increasing water temperature (temperature range 4-25 degrees C), indicating broad thermal tolerance. In the factorial experiment, triplicate plants were exposed to 3 temperatures (10, 18 and 25 C) and 3 nitrate concentrations (10,30 and 100 mu M). Most metrics (leaf elongation, growth, relative growth, wasting index) exhibited a statistically significant temperature effect but no nutrient concentration effect, indicating the importance of temperature on metabolic rates. Plants at 18 and 25 C had significantly more wasting disease than plants at 10 C. Tissue delta N-15 and C:N values exhibited significant nutrient concentration and temperature effects, indicating that both factors influenced how much NO3 was incorporated into the tissues. Whole plant non structural carbohydrate content exhibited no significant response to either temperature or nitrate concentration. Temperature played a dominant role controlling Z. marina response to nutrients; nitrogen toxicity was not observed, and in general the effects of temperature and nutrients were not synergistic. This work highlights the complex nature of Z marina response to environmental conditions; additional multifactor experiments will be required to tease apart these interactions. Published by Elsevier B.V. C1 US EPA, Western Ecol Div, Newport, OR 97365 USA. RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Ctr Dr, Newport, OR 97365 USA. EM kaldy.jim@epa.gov FU U.S. Environmental Protection Agency FX Technical assistance was provided by J. Stecher, T.C. Mochon-Collura and K. Marko. Stable isotope samples were analyzed at the US EPA's Integrated Stable Isotope Research Facility (ISIRF) at the Western Ecology Division, Corvallis, OR, USA. This manuscript benefitted from review and discussion with following individuals; C. Andersen, M. Frazier, C. Janousek, R. Ozretich, D. Shafer, G. Thursby. Comments from anonymous reviewers and S. Thrush improved the manuscript. The information in this document has been funded wholly by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. [ST] NR 48 TC 9 Z9 9 U1 12 U2 68 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 EI 1879-1697 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD APR PY 2014 VL 453 BP 108 EP 115 DI 10.1016/j.jembe.2013.12.020 PG 8 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AF1MB UT WOS:000334476900014 ER PT J AU Resnik, DB AF Resnik, David B. TI The morality of patents on preimplantation genetic diagnosis SO NATURE BIOTECHNOLOGY LA English DT Letter C1 Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA. RP Resnik, DB (reprint author), Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA. EM resnikd@niehs.nih.gov NR 13 TC 0 Z9 0 U1 1 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1087-0156 EI 1546-1696 J9 NAT BIOTECHNOL JI Nat. Biotechnol. PD APR PY 2014 VL 32 IS 4 BP 319 EP 320 DI 10.1038/nbt.2865 PG 3 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AE9PT UT WOS:000334340800011 PM 24714476 ER PT J AU Rosenzweig, S Sorial, GA Sahle-Demessie, E McAvoy, DC Hassan, AA AF Rosenzweig, Shirley Sorial, George A. Sahle-Demessie, Endalkachew McAvoy, Drew C. Hassan, Ashraf A. TI Effect of Chloride Ions and Water Chemistry on Copper(II) Adsorption on Functionalized and Pristine Carbon Nanotubes Compared to Activated Carbon F-400 SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Adsorption; Carbon nanotubes; Chloride; Copper; Deprotonation; MINEQL(+) ID METAL IMPURITIES; ORGANIC-CHEMICALS; AQUEOUS-SOLUTION; SORPTION; ACID; PURIFICATION; SUSPENSIONS; TOXICITY; KINETICS; REMOVAL AB The objective of this study was to investigate the effect of chloride ions (Cl-) on Cu2+ adsorption to carbon nanotubes (CNT). The isotherms showed a significant decrease in adsorption capacity on F-400, pristine, and acid-functionalized CNT in the presence of Cl-, but had little effect on alcohol-functionalized CNT. Several inductively coupled plasma (ICP) analyses measured the impurities concentration of (1) aqueous-phase isotherm solute, (2) as-received, and (3) acid-washed CNT solutions. Chemical-equilibrium-modeling software MINEQL(+) calculations were applied to compare ICP results to complexes formation. The model suggested that some solid-phase residual-catalytic metals, such as Cr2+, after released in water from as-received CNT, formed aqueous-phase complexes and were readsorbed. The 18-metal ICP results were more than two orders of magnitude lower (<4 mu M/g-adsorbent) than the lowest isotherm Cu2+ concentration (157 mu M) without significant impact on the isotherm results. The reduced adsorptive capacity of acid-functionalized CNT was related to the mechanisms of water molecule displacement followed by deprotonation during Cu2+ sorption in the CNT-surface hydration layer and its interaction with other species, generating different ion exchange forces. Brunauer-Emmett-Teller and pore-distribution measurements defined bulk water structure within CNT bundles. Zeta-charge and pHpzc measurements compared as-received and hybrid-CNT indicating copper chemisorption. Functionalized CNT remained negatively charged above pH 2.7, suggesting consistent adsorptive capacity at pH>5.1, when less Cu2+ ions are present in solution. scanning electron microscopy-energy dispersive X-ray spectroscopy analysis showed impurities on as-received F-400 and positively charged surface at pH 5.1 (pHpzc 7.1) explaining possible electrostatic attraction of Cl- ions, blocking adsorptive sites, reducing its adsorptive capacity for Cu2+. C1 [Rosenzweig, Shirley; Sorial, George A.; McAvoy, Drew C.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn Program, Cincinnati, OH 45221 USA. [Sahle-Demessie, Endalkachew; Hassan, Ashraf A.] US EPA, Off Res & Dev, NRMRL, Cincinnati, OH 45268 USA. RP Sorial, GA (reprint author), Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn Program, POB 210012, Cincinnati, OH 45221 USA. EM George.Sorial@uc.edu FU EPA project [S-10591-QP-1-0] FX The authors want to thank Stephen Harmon and Debby Roose for their work on SEM/EDS and ICP-AES analysis. This study was supported by EPA project number S-10591-QP-1-0, Environmental Fate of Nano-scale particles and their influence on mobility of persistent contaminants: a comparative study of natural materials with engineered nanoparticles. NR 41 TC 3 Z9 3 U1 2 U2 25 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 EI 1573-2932 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD APR PY 2014 VL 225 IS 4 AR 1913 DI 10.1007/s11270-014-1913-1 PG 17 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA AF2YL UT WOS:000334578300006 ER PT J AU Guyton, KZ Hogan, KA Scott, CS Cooper, GS Bale, AS Kopylev, L Barone, S Makris, SL Glenn, B Subramaniam, RP Gwinn, MR Dzubow, RC Chiu, WA AF Guyton, Kathryn Z. Hogan, Karen A. Scott, Cheryl Siegel Cooper, Glinda S. Bale, Ambuja S. Kopylev, Leonid Barone, Stanley, Jr. Makris, Susan L. Glenn, Barbara Subramaniam, Ravi P. Gwinn, Maureen R. Dzubow, Rebecca C. Chiu, Weihsueh A. TI Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID CANCER-RISK ASSESSMENT; LIVER-TUMOR-INDUCTION; COLOR-VISION LOSS; AIRCRAFT MANUFACTURING WORKERS; VISUAL CONTRAST SENSITIVITY; PHARMACOKINETIC PBPK MODEL; LYASE MEDIATED CLEAVAGE; EXTENDED-FOLLOW-UP; DRY-CLEANING SHOPS; MALE B6C3F1 MOUSE AB BACKGROUND: The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloro-ethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS). OBJECTIVES: We reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA's Toxicological Review of Tetrachloroethylene (Perchloroethylene). METHODS: The updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severity, and background rate) in interpreting experimental animal cancer findings. Considerations in evaluating epidemiological studies included the quality (e.g., specificity) of the exposure assessment methods and other essential design features, and the potential for alternative explanations for observed associations (e.g., bias or confounding). DISCUSSION: Toxicokinetic modeling aided in characterizing the complex metabolism and multiple metabolites that contribute to PCE toxicity. The exposure assessment approach-a key evaluation factor for epidemiological studies of bladder cancer, non-Hodgkin lymphoma, and multiple myeloma-provided suggestive evidence of carcinogenicity. Bioassay data provided conclusive evidence of carcinogenicity in experimental animals. Neurotoxicity was identified as a sensitive non-cancer health effect, occurring at low exposures: a conclusion supported by multiple studies. Evidence was integrated from human, experimental animal, and mechanistic data sets in assessing adverse health effects of PCE. CONCLUSIONS: PCE is likely to be carcinogenic to humans. Neurotoxicity is a sensitive adverse health effect of PCE. C1 [Guyton, Kathryn Z.; Hogan, Karen A.; Scott, Cheryl Siegel; Cooper, Glinda S.; Bale, Ambuja S.; Kopylev, Leonid; Makris, Susan L.; Glenn, Barbara; Subramaniam, Ravi P.; Gwinn, Maureen R.; Chiu, Weihsueh A.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Barone, Stanley, Jr.] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA. [Dzubow, Rebecca C.] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA. RP Guyton, KZ (reprint author), Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France. EM Guytonk@iarc.fr NR 122 TC 11 Z9 11 U1 3 U2 47 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2014 VL 122 IS 4 BP 325 EP 334 DI 10.1289/ehp.1307359 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AE5ZY UT WOS:000334069100014 PM 24531164 ER PT J AU Burnett, RT Pope, CA Ezzati, M Olives, C Lim, SS Mehta, S Shin, HH Singh, G Hubbell, B Brauer, M Anderson, HR Smith, KR Balmes, JR Bruce, NG Kan, HD Laden, F Pruss-Ustun, A Michelle, CT Gapstur, SM Diver, WR Cohen, A AF Burnett, Richard T. Pope, C. Arden, III Ezzati, Majid Olives, Casey Lim, Stephen S. Mehta, Sumi Shin, Hwashin H. Singh, Gitanjali Hubbell, Bryan Brauer, Michael Anderson, H. Ross Smith, Kirk R. Balmes, John R. Bruce, Nigel G. Kan, Haidong Laden, Francine Pruess-Ustuen, Annette Turner, Michelle C. Gapstur, Susan M. Diver, W. Ryan Cohen, Aaron TI An Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposure SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID LONG-TERM EXPOSURE; AIR-POLLUTION; CARDIOVASCULAR-DISEASE; LUNG-CANCER; MORTALITY; ASSOCIATION AB BACKGROUND: Estimating the burden of disease attributable to long-term exposure to fine particulate matter (PM2.5) in ambient air requires knowledge of both the shape and magnitude of the relative risk (RR) function. However, adequate direct evidence to identify the shape of the mortality RR functions at the high ambient concentrations observed in many places in the world is lacking. OBJECTIVE: We developed RR functions over the entire global exposure range for causes of mortality in adults: ischemic heart disease (IHD), cerebrovascular disease (stroke), chronic obstructive pulmonary disease (COPD), and lung cancer (LC). We also developed RR functions for the incidence of acute lower respiratory infection (ALRI) that can be used to estimate mortality and lost-years of healthy life in children < 5 years of age. METHODS: We fit an integrated exposure-response (IER) model by integrating available RR information from studies of ambient air pollution (AAP), second hand tobacco smoke, household solid cooking fuel, and active smoking (AS). AS exposures were converted to estimated annual PM2.5 exposure equivalents using inhaled doses of particle mass. We derived population attributable fractions (PAFs) for every country based on estimated worldwide ambient PM2.5 concentrations. RESULTS: The IER model was a superior predictor of RR compared with seven other forms previously used in burden assessments. The percent PAF attributable to AAP exposure varied among countries from 2 to 41 for IHD, 1 to 43 for stroke, < 1 to 21 for COPD, < 1 to 25 for LC, and < 1 to 38 for ALRI. CONCLUSIONS: We developed a fine particulate mass-based RR model that covered the global range of exposure by integrating RR information from different combustion types that generate emissions of particulate matter. The model can be updated as new RR information becomes available. C1 [Burnett, Richard T.; Shin, Hwashin H.] Hlth Canada, Ottawa, ON K1A 0K9, Canada. [Pope, C. Arden, III] Brigham Young Univ, Provo, UT 84602 USA. [Ezzati, Majid] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England. [Olives, Casey] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Lim, Stephen S.] Inst Hlth Metr & Evaluat, Seattle, WA USA. [Mehta, Sumi] Global Alliance Clean Cookstoves, Washington, DC USA. [Singh, Gitanjali] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA. [Hubbell, Bryan] US EPA, Res Triangle Pk, NC 27711 USA. [Brauer, Michael] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada. [Anderson, H. Ross] Kings Coll London, MRC PHE Ctr Environm & Hlth, London, England. [Smith, Kirk R.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Balmes, John R.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Balmes, John R.] Univ Calif Berkeley, Sch Med, Berkeley, CA 94720 USA. [Bruce, Nigel G.] Univ Liverpool, Dept Publ Hlth & Policy, Liverpool L69 3BX, Merseyside, England. [Kan, Haidong] Fudan Univ, Sch Publ Hlth, Shanghai 200433, Peoples R China. [Laden, Francine] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA. [Pruess-Ustuen, Annette] WHO, CH-1211 Geneva, Switzerland. [Turner, Michelle C.] Univ Ottawa, Inst Populat Hlth, Ottawa, ON, Canada. [Gapstur, Susan M.; Diver, W. Ryan] Amer Canc Soc, Atlanta, GA 30329 USA. [Cohen, Aaron] Hlth Effects Inst, Boston, MA USA. RP Burnett, RT (reprint author), Hlth Canada, Environm Hlth Sci & Res Bur, Environm & Radiat Hlth Sci Directorate,Ctr Enviro, Populat Studies Div,Hlth Environm & Consumer Safe, Room 134,50 Columbine Driveway, Ottawa, ON K1A 0K9, Canada. EM rick.burnett@hc-sc.gc.ca OI Hubbell, Bryan/0000-0002-7963-3438; Brauer, Michael/0000-0002-9103-9343 FU William and Flora Hewlett Foundation; U.S. Environmental Protection Agency; worldwide motor vehicle industry FX A.C. received support from the William and Flora Hewlett Foundation.; A.C. is employed by the Health Effects Institute (HEI). The HEI receives about half of its core funds from the U.S. Environmental Protection Agency and half from the worldwide motor vehicle industry, although other public and private organizations periodically support special projects or certain research programs. The views expressed in this article do not represent those of the HEI or its sponsors. A.P.-U. is a staff member of the World Health Organization (WHO), and the views expressed in this article do not necessarily represent the views, decisions, or policies of the WHO. This article should not be reproduced for use in association with the promotion of commercial products, services, or any legal entity. The WHO does not endorse any specific organization or products. Any reproduction of this article cannot include the use of the WHO logo. NR 32 TC 170 Z9 175 U1 40 U2 210 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2014 VL 122 IS 4 BP 397 EP 403 DI 10.1289/ehp.1307049 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AE5ZY UT WOS:000334069100024 PM 24518036 ER PT J AU Burkart, KM Manichaikul, A Wilk, JB Ahmed, FS Burke, GL Enright, P Hansel, NN Haynes, D Heckbert, SR Hoffman, EA Kaufman, JD Kurai, J Loehr, L London, SJ Meng, Y O'Connor, GT Oelsner, E Petrini, M Pottinger, TD Powell, CA Redline, S Rotter, JI Smith, LJ Artigas, MS Tobin, MD Tsai, MY Watson, K White, W Young, TR Rich, SS Barr, RG AF Burkart, Kristin M. Manichaikul, Ani Wilk, Jemma B. Ahmed, Firas S. Burke, Gregory L. Enright, Paul Hansel, Nadia N. Haynes, Demondes Heckbert, Susan R. Hoffman, Eric A. Kaufman, Joel D. Kurai, Jun Loehr, Laura London, Stephanie J. Meng, Yang O'Connor, George T. Oelsner, Elizabeth Petrini, Marcy Pottinger, Tess D. Powell, Charles A. Redline, Susan Rotter, Jerome I. Smith, Lewis J. Artigas, Maria Soler Tobin, Martin D. Tsai, Michael Y. Watson, Karol White, Wendy Young, Taylor R. Rich, Stephen S. Barr, R. Graham TI APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema SO EUROPEAN RESPIRATORY JOURNAL LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; GENOME-WIDE ASSOCIATION; AIR-FLOW OBSTRUCTION; ENDOTHELIAL GROWTH-FACTOR; SUBTILISIN/KEXIN TYPE 9; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-M; MONOCLONAL-ANTIBODY; MESA LUNG; SUBCLINICAL ATHEROSCLEROSIS AB Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3 x 10(-6)) and a second (rs707974) in the combined European-American and African-American analysis (p =1.38 x 10(-7)). Both single-nucleotide polyrnorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEVi/FVC ratio and greater per cent emphysema. These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema. C1 [Burkart, Kristin M.; Ahmed, Firas S.; Oelsner, Elizabeth; Pottinger, Tess D.; Barr, R. Graham] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA. [Manichaikul, Ani; Rich, Stephen S.] Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA. [Wilk, Jemma B.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Wilk, Jemma B.; Redline, Susan] Harvard Univ, Sch Med, Boston, MA USA. [Ahmed, Firas S.] Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA. [Burke, Gregory L.] Wake Forest Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA. [Enright, Paul] Univ Arizona, Dept Med, Tucson, AZ USA. [Hansel, Nadia N.] Johns Hopkins Univ, Dept Med, Baltimore, MD USA. [Haynes, Demondes; Petrini, Marcy] Univ Mississippi, Dept Med, Jackson, MS 39216 USA. [Heckbert, Susan R.; Kaufman, Joel D.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Hoffman, Eric A.] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA. [Kaufman, Joel D.] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Kaufman, Joel D.] Univ Washington, Dept Med, Seattle, WA USA. [Kaufman, Joel D.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Kurai, Jun; Powell, Charles A.] Mt Sinai Hosp, Dept Med, New York, NY 10029 USA. [Loehr, Laura] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [London, Stephanie J.] Natl Inst Hlth & Human Serv, Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. [Meng, Yang] Broad Inst MIT & Harvard, Cambridge, MA USA. [O'Connor, George T.] Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA. [O'Connor, George T.] NHLBI, Framingham Heart Study, Framingham, MA USA. [Redline, Susan] Brigham & Womens Hosp, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. [Rotter, Jerome I.] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA. [Smith, Lewis J.] Northwestern Univ, Dept Med, Chicago, IL 60611 USA. [Artigas, Maria Soler; Tobin, Martin D.] Univ Leicester, Dept Hlth Sci, Genet Epidemiol Grp, Leicester, Leics, England. [Tobin, Martin D.] Glenfield Hosp, Leicester Resp Biomed Res Unit, Natl Inst Hlth Res, Leicester, Leics, England. [Tsai, Michael Y.] Univ Minnesota, Dept Lab Med Pathol, Minneapolis, MN USA. [Watson, Karol] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [White, Wendy] Tougaloo Coll, Jackson Heart Study, Tougaloo, MS USA. [Young, Taylor R.] MIT, Broad Inst, Cambridge, MA 02139 USA. [Young, Taylor R.] Harvard Univ, Cambridge, MA 02138 USA. [Barr, R. Graham] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA. RP Barr, RG (reprint author), Columbia Univ, Med Ctr, 630 West 168th St,PH 9 East Room 105, New York, NY 10032 USA. EM rgb9@columbia.edu RI Kaufman, Joel/B-5761-2008; Soler Artigas, Maria/L-6529-2013; OI Kaufman, Joel/0000-0003-4174-9037; Soler Artigas, Maria/0000-0002-3213-1107; Smith, Lewis J/0000-0002-4728-1562; Pottinger, Tess/0000-0003-0647-5712; POWELL, CHARLES/0000-0003-3509-891X; London, Stephanie/0000-0003-4911-5290 FU National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) [RC1-HL100543, R01-HL077612, R01-HL093081]; NIH/National Human Genome Research Institute [U01HG004402]; NIH [HHSN268200625226C, N01-HC-55015, N01-HC-55016, N01-HC-55021, N01-HC-55019, N01-HC-55020, N01-HC-55017, N01-HC-55018, UL1RR025005]; NIH Roadmap for Medical Research; Broad Institute [N01-HC-65226]; Coronary Artery Risk Development in Young Adults (CARDIA) [N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-95095, N01-HC-45204, N01-HC-45205, N01-HC-05187, N01-HC-45134, N01-HC-95100]; Cleveland Family Study (CFS) [RO1 HL46380-01-16]; NHLBI [N01-HC-85239, N01-HC-85079, N01-HC-85080, N01-HC-85081, N01-HC-85082, N01-HC-85083, N01-HC-85084, N01-HC-85085, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01-HC-75150, N01-HC-45133, N01 HC-55222, U01 HL080295, AG-023629, AG-15928, AG-20098, AG-027058]; Environmental Protection Agency (EPA) [RD831697]; Medical Research Council [G0902313]; National Institute for Health Research; Division of Intramural Research, National Institute of Environmental Health Sciences, NIH; Department of Health and Human Services; [N01-HC-25195]; [N01-HC-95170]; [N01-HC-95171]; [N01-HC-95172]; [N01-HC-95159]; [N01-HC-95160]; [N01-HC-95161]; [N01-HC-95162]; [N01-HC-95163]; [N01-HC-95164]; [N01-HC-95165]; [N01-HC-95166]; [N01-HC-95167]; [N01-HC-95168]; [N01-HC-95169]; [RR-024156]; [R01-HL-071051]; [R01-HL-071205]; [R01-HL-071250]; [R01-HL-071251]; [R01-HL-071252]; [R01-HL-071258]; [R01-HL-071259]; [HHSN268201100005C]; [HHSN268201100006C]; [HHSN268201100007C]; [HHSN268201100008C]; [HHSN268201100009C]; [HHSN268201100010C]; [HHSN268201100011C]; [HHSN268201100012C]; [R01HL087641]; [R01HL59367]; [R01HL086694] FX National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) grants RC1-HL100543, R01-HL077612 and R01-HL093081, in addition to the following. Atherosclerosis Risk in Communities: HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, R01HL087641, R01HL59367, R01HL086694, NIH/National Human Genome Research Institute contract U01HG004402, NIH contract HHSN268200625226C, N01-HC-55015, N01-HC-55016, N01-HC-55021, N01-HC-55019, N01-HC-55020, N01-HC-55017 and N01-HC-55018, and UL1RR025005, a component of the NIH and NIH Roadmap for Medical Research; Broad Institute: N01-HC-65226; Coronary Artery Risk Development in Young Adults (CARDIA): N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-95095, N01-HC-45204, N01-HC-45205, N01-HC-05187, N01-HC-45134 and N01-HC-95100; Cleveland Family Study (CFS): RO1 HL46380-01-16; Cardiovascular Health Study (CHS): CHS research was supported by NHLBI contracts N01-HC-85239, N01-HC-85079, N01-HC-85080, N01-HC-85081, N01-HC-85082, N01-HC-85083, N01-HC-85084, N01-HC-85085, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01-HC-75150, N01-HC-45133, N01 HC-55222, U01 HL080295, AG-023629, AG-15928, AG-20098 and AG-027058 with additional contribution from National Institute of Neurological Diseases and the National Institute on Aging; Framingham Heart Study (FHS): N01-HC-25195; Jackson Heart Study (JHS): N01-HC-95170, N01-HC-95171 and N01-HC-95172; Multi-Ethnic Study of Atherosclerosis (MESA): N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01-HL093081, RR-024156, R01-HL-071051, R01-HL-071205, R01-HL-071250, R01-HL-071251, R01-HL-071252, R01-HL-071258, R01-HL-071259 and Environmental Protection Agency (EPA) grant RD831697; SpiroMeta: M.D. Tobin holds a Medical Research Council Senior Clinical Fellowship (G0902313) and research undertaken by M.D. Tobin was part-funded by the National Institute for Health Research. S.J. London is supported by the Division of Intramural Research, National Institute of Environmental Health Sciences, NIH and the Department of Health and Human Services. NR 99 TC 10 Z9 10 U1 0 U2 7 PU EUROPEAN RESPIRATORY SOC JOURNALS LTD PI SHEFFIELD PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND SN 0903-1936 EI 1399-3003 J9 EUR RESPIR J JI Eur. Resp. J. PD APR PY 2014 VL 43 IS 4 BP 1003 EP 1017 DI 10.1183/09031936.00147612 PG 15 WC Respiratory System SC Respiratory System GA AE8OT UT WOS:000334261900015 PM 23900982 ER PT J AU Gordon, SC Butala, JH Carter, JM Elder, A Gordon, T Gray, G Sayre, PG Schulte, PA Tsai, CS West, J AF Gordon, Steven C. Butala, John H. Carter, Janet M. Elder, Alison Gordon, Terry Gray, George Sayre, Philip G. Schulte, Paul A. Tsai, Candace S. West, Jay TI Workshop report: Strategies for setting occupational exposure limits for engineered nanomaterials SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Occupational exposure limit; Engineered nanomaterial; OEL; ENM; Workshop; Strategies; Alternatives ID WALLED CARBON NANOTUBES; RISK-ASSESSMENT; NANOPARTICLES; DEPOSITION; MODEL; PARTICLES; DOSIMETRY; TOXICITY; HUMANS; LUNG AB Occupational exposure limits (OELs) are important tools for managing worker exposures to chemicals; however, hazard data for many engineered nanomaterials (ENMs) are insufficient for deriving OELs by traditional methods. Technical challenges and questions about how best to measure worker exposures to ENMs also pose barriers to implementing OELs. New varieties of ENMs are being developed and introduced into commerce at a rapid pace, further compounding the issue of OEL development for ENMs. A Workshop on Strategies for Setting Occupational Exposure Limits for Engineered Nanomaterials, held in September 2012, provided an opportunity for occupational health experts from various stakeholder groups to discuss possible alternative approaches for setting OELs for ENMs and issues related to their implementation. This report summarizes the workshop proceedings and findings, identifies areas for additional research, and suggests potential avenues for further progress on this important topic. (C) 2014 The Authors. Published by Elsevier Inc. C1 [Gordon, Steven C.] 3M Co, Toxicol Assessment & Compliance Assurance, St Paul, MN 55144 USA. [Butala, John H.] Toxicol Consultants Inc, Gibsonia, PA 15044 USA. [Carter, Janet M.] US Dept Labor, Washington, DC 20210 USA. [Elder, Alison] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA. [Gordon, Terry] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY 10987 USA. [Gray, George] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Environm & Occupat Hlth, Washington, DC 20037 USA. [Gray, George] George Washington Univ, Sch Publ Hlth & Hlth Serv, Ctr Risk Sci & Publ Hlth, Washington, DC 20037 USA. [Sayre, Philip G.] US EPA, Washington, DC 20460 USA. [Schulte, Paul A.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Tsai, Candace S.] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA. [West, Jay] Amer Chem Council, Nanotechnol Panel, Washington, DC 20002 USA. RP Gordon, SC (reprint author), 3M Co, Toxicol Assessment & Compliance Assurance, 3M Ctr,Bldg 220-6E-03, St Paul, MN 55144 USA. EM scgordon@mmm.com; butala@jhbutala.com; carter.janet@dol.gov; alison_elder@urmc.rochester.edu; terry.gordon@nyumc.org; gmgray@gwu.edu; sayre.phil@epa.gov; pas4@cdc.gov; tsai51@purdue.edu; jay_west@americanchemistry.com FU National Institute for Occupational Safety and Health [R13 OH010337]; American Chemistry Council Nanotechnology Panel; National Science Foundation [123634] FX The authors wish to thank the workshop speakers and participants for their valuable contributions to the discussions and results of the workshop. We also thank the National Institute for Occupational Safety and Health (Grant R13 OH010337) and the American Chemistry Council Nanotechnology Panel for their financial support; The George Washington University School of Public Health and Health Services for hosting the workshop; Mary Butow, Julie Goodnight, Mary Popovech, Eric Saunders, and Chia Thach for serving as note takers; and Jessica Knutson, Andrew MacCachran, and Schubert Fabros of the American Chemistry Council for handling the many logistical details. This material is based upon work supported by the National Science Foundation under Grant Number 123634. NR 37 TC 14 Z9 14 U1 2 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD APR PY 2014 VL 68 IS 3 BP 305 EP 311 DI 10.1016/j.yrtph.2014.01.005 PG 7 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA AE6YY UT WOS:000334145100001 PM 24462629 ER PT J AU Rochman, CM Lewison, RL Eriksen, M Allen, H Cook, AM Teh, SJ AF Rochman, Chelsea M. Lewison, Rebecca L. Eriksen, Marcus Allen, Harry Cook, Anna-Marie Teh, Swee J. TI Polybrominated diphenyl ethers (PBDEs) in fish tissue may be an indicator of plastic contamination in marine habitats SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Plastic debris; Myctophid; Polybrominated diphenyl ethers (PBDEs); South Atlantic Gyre ID PERSISTENT ORGANIC POLLUTANTS; POLYCHLORINATED-BIPHENYLS PCBS; BISPHENOL-A CONTAMINATION; WESTERN NORTH PACIFIC; RESIN PELLETS; SUBTROPICAL GYRE; ATLANTIC-OCEAN; DEBRIS; SEA; ENVIRONMENT AB The accumulation of plastic debris in pelagic habitats of the subtropical gyres is a global phenomenon of growing concern, particularly with regard to wildlife. When animals ingest plastic debris that is associated with chemical contaminants, they are at risk of bioaccumulating hazardous pollutants. We examined the relationship between the bioaccumulation of hazardous chemicals in myctophid fish associated with plastic debris and plastic contamination in remote and previously unmonitored pelagic habitats in the South Atlantic Ocean. Using a published model, we defined three sampling zones where accumulated densities of plastic debris were predicted to differ. Contrary to model predictions, we found variable levels of plastic debris density across all stations within the sampling zones. Mesopelagic lanternfishes, sampled from each station and analyzed for bisphenol A (BPA), alkylphenols, alkylphenol ethoxylates, polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), exhibited variability in contaminant levels, but this variability was not related to plastic debris density for most of the targeted compounds with the exception of PBDEs. We found that myctophid sampled at stations with greater plastic densities did have significantly larger concentrations of BDE#s 183 -209 in their tissues suggesting that higher brominated congeners of PBDEs, added to plastics as flame-retardants, are indicative of plastic contamination in the marine environment. Our results provide data on a previously unsampled pelagic gyre and highlight the challenges associated with characterizing plastic debris accumulation and associated risks to wildlife. (C) 2014 Elsevier B.V. All rights reserved. C1 [Rochman, Chelsea M.; Teh, Swee J.] Univ Calif Davis, Sch Vet Med, Aquat Hlth Program, Davis, CA 95616 USA. [Lewison, Rebecca L.] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA. [Eriksen, Marcus] 5 Gyres Inst, Los Angeles, CA 90016 USA. [Allen, Harry; Cook, Anna-Marie] US Environm Protect Agcy Reg 9, Superfund Div, San Francisco, CA 94105 USA. RP Rochman, CM (reprint author), Univ Calif Davis, Sch Vet Med, Aquat Hlth Program, Davis, CA 95616 USA. EM cmrochman@ucdavis.edu OI Lewison, Rebecca/0000-0003-3065-2926 FU 5 Gyres Institute; Algalita Marine Research Foundation; EPA Superfund Region; CSU COAST, Kickstarter; Aquatic Health Program at the University of California, Davis; National Science Foundation [2010101195] FX This material is based on work supported by The 5 Gyres Institute, Algalita Marine Research Foundation, EPA Superfund Region 9, CSU COAST, Kickstarter, The Aquatic Health Program at the University of California, Davis and a National Science Foundation Graduate Research Fellowship (Grant No. 2010101195). We thank C. R. Rochman, L and B. Schackner, L. Blinn, H. Johnson, V. Sayward, M. Armen, K. Fry, J. McGuigan, J. Illinois, G. Mendoza, J. Abbott, N. Fabina, C. Heavener, K. Gower, C. Fyfe, T. Hoyer, V. Compton, A. Grubb, J. Severino and P. Lopez for donating funding to our Kickstarter campaign. J. Aderhold and B. Hepner of Aqualytical donated the C.L.A.M. for water sampling. G. Wu, S. Acuna and S. Serratto assisted with fish dissection, P. Davison assisted with taxonomic ID, AXYS Analytical Ltd. performed the analytical chemistry, E. Hoh and N. Dodder assisted with chemical analyses, K. Callinan prepared Fig. I and B. Monteleone, A. Cummins, J. Lemon, S. Wilson and the rest of the 5Gyres crew assisted in the field. We thank A. J. Underwood, P. Chapman, M. A. Browne, B. Hammock and A. Javidmehr for advising on statistical analysis, K. Miles and K. Law for advising on experimental design and N. Maximenko for providing model results. The authors declare no conflicts of interest NR 71 TC 26 Z9 30 U1 12 U2 122 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD APR 1 PY 2014 VL 476 BP 622 EP 633 DI 10.1016/j.scitotenv.2014.01.058 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE1ZG UT WOS:000333772500063 PM 24496035 ER PT J AU Gao, YH An, JY Ryu, HD Lee, HS AF Gao, Yaohuan An, Junyeong Ryu, Hodon Lee, Hyung-Sool TI Microbial Fuel Cells as Discontinuous Portable Power Sources: Syntropic Interactions with Anode- Respiring Bacteria SO CHEMSUSCHEM LA English DT Article DE biopolymers; electron transfer; energy conversion; microbial fuel cells; syntrophy ID CONVERSION AB For microbial fuel cells (MFCs) to work as portable power sources used in a discontinuous manner, anode-respiring bacteria (ARB) should survive for at least several days in the absence of exogenous electron donors, and immediately generate current upon addition of an electron donor. Here, we proved that biopolymer-accumulating bacteria provide substrate (fuel) for ARB to generate current in lack of exogenous electron donor in 4 days, which allows MFCs to be used as portable power sources. C1 [Gao, Yaohuan; An, Junyeong; Lee, Hyung-Sool] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Ryu, Hodon] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Gao, YH (reprint author), Univ Waterloo, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. EM hyungsool@uwaterloo.ca FU National Sciences and Engineering Research Council of Canada (NSERC) (NSERC DG) [402045-2011]; Ministry of Economic Development and Innovation FX This work was financially supported by National Sciences and Engineering Research Council of Canada (NSERC) entitled "Development of energy-efficient wastewater treatment technology using principles of microbial fuel/electrolysis cells" (NSERC DG #402045-2011) and Ministry of Economic Development and Innovation entitled "Development of sustainable anaerobic wastewater treatment technologies: recovery of value-added products". The authors thank Maria Mesquita and Jin Chao for helping with microscope operation. NR 21 TC 7 Z9 7 U1 1 U2 28 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1864-5631 EI 1864-564X J9 CHEMSUSCHEM JI ChemSusChem PD APR PY 2014 VL 7 IS 4 BP 1026 EP 1029 DI 10.1002/cssc.201301085 PG 4 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA AE1TX UT WOS:000333754200005 PM 24574020 ER PT J AU Blett, TF Lynch, JA Pardo, LH Huber, C Haeuber, R Pouyat, R AF Blett, Tamara F. Lynch, Jason A. Pardo, Linda H. Huber, Cindy Haeuber, Richard Pouyat, Richard TI FOCUS: A pilot study for national-scale critical loads development in the United States SO ENVIRONMENTAL SCIENCE & POLICY LA English DT Article DE Air quality; Acidification; Nitrogen saturation; Eutrophication; Ecological thresholds ID ATMOSPHERIC NITROGEN DEPOSITION; ACIDIFICATION; USA AB The development and use of critical loads of air pollutant deposition in the U.S. is gaining momentum, and recent research efforts in the U.S. have produced valuable data for calculating critical loads. Critical loads are used to quantify the levels of air pollutants that are expected to impact forest health, soil fertility, aquatic biota condition, and other ecosystem responses. In addition, model refinements for improving critical loads estimates, and maps for illustrating critical loads for acidification and nitrogen saturation and eutrophication resulting from excess nutrient nitrogen, have been developed at various scales. However, prior to the effort described here, no cohesive process existed to provide a national-scale critical loads database and maps as a unified product representing all U.S. ecosystems. The FOCUS (Focal Center Utility Study) Project was initiated to coordinate the development and implementation of a clear, consistent, repeatable process for calculating and mapping critical loads within the U.S. In the FOCUS Phase I Pilot Study, empirical and calculated critical loads data for the U.S. were synthesized from dozens of regional and national-scale monitoring networks, research projects and publically available databases following an approach similar to that used in Europe. The United Nations Economic Commission for Europe (UNECE), through its International Cooperative Programme on Modelling and Mapping of Critical Levels & Loads and Air Pollution Effects, Risks and Trends (ICP-M&M) collects, analyzes and maps critical loads data. Countries participating in the Convention on Long-range Transboundary Air Pollution (CLRTAP) use a Critical Loads "Focal Center" in each country to serve as the point of contact for submitting regional and national-scale critical loads data to the ICP-M&M. One of the purposes of this study was to develop a foundation for interacting with other Focal Centers by assembling critical loads data, creating a database, establishing modeling protocols, and developing infrastructure within the U.S to report and update critical loads on a national scale. Because the U.S. does not currently have an officially designated Focal Center, critical loads data were provided as an informal, unofficial submission to the Coordination Center for Effects (CCE) of the ICP-M&M in March 2011, in the interest of international cooperation and exchange of information on the effects of atmospheric deposition of pollutants on ecosystems. We envision that these data will enable U.S. scientists, land managers, and environmental policymakers to enter into a productive and meaningful dialogue within the US, and also with the international scientific community on methods for estimating, calculating, mapping, interpreting, and refining critical loads for the effects of acidification and excess nutrient nitrogen on terrestrial and aquatic ecosystems. This paper describes the process used to develop national-scale critical loads in the U.S., summarizes the FOCUS Phase I approach and database development effort, and presents some initial national-scale critical loads mapping products. Published by Elsevier Ltd. C1 [Blett, Tamara F.] Natl Pk Serv, Air Resources Div, Lakewood, CO 80225 USA. [Lynch, Jason A.; Haeuber, Richard] US EPA, Clean Air Markets Div, Washington, DC 20040 USA. [Pardo, Linda H.] Univ Vermont, Aiken Ctr, USDA, No Res Stn,Forest Serv, Burlington, VT 05405 USA. [Huber, Cindy] Illinois State Water Survey, Natl Atmospher Deposit Program, Champaign, IL 61820 USA. [Pouyat, Richard] ARS, USDA, R&D, Arlington, VA 22209 USA. RP Blett, TF (reprint author), Natl Pk Serv, Air Resources Div, POB 25287, Lakewood, CO 80225 USA. EM tamara_blett@nps.gov; lynch.jason@epa.gov; lpardo@fs.fed.us; chuber@illinois.edu; haeuber.richard@epa.gov; rpouyat@fs.fed.us NR 41 TC 8 Z9 9 U1 2 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1462-9011 EI 1873-6416 J9 ENVIRON SCI POLICY JI Environ. Sci. Policy PD APR PY 2014 VL 38 BP 225 EP 236 DI 10.1016/j.envsci.2013.12.005 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE1HL UT WOS:000333720300021 ER PT J AU Belaire, JA Kreakie, BJ Keitt, T Minor, E AF Belaire, J. Amy Kreakie, Betty J. Keitt, Timothy Minor, Emily TI Predicting and Mapping Potential Whooping Crane Stopover Habitat to Guide Site Selection for Wind Energy Projects SO CONSERVATION BIOLOGY LA English DT Article DE avian migration; en route bird conservation; random forests; site selection; stopover; Whooping Crane (Grus americana); wind farm; Bosques aleatorios; conservacion de aves en ruta; descanso; granja de viento; Grulla Americana (Grus americana); migracion de aves; seleccion de sitio ID SPECIES DISTRIBUTION MODELS; PSEUDO-ABSENCES; RANDOM FORESTS; BIRDS; DISTRIBUTIONS; CONSERVATION; CHALLENGES; IMPACTS; FARMS AB Migratory stopover habitats are often not part of planning for conservation or new development projects. We identified potential stopover habitats within an avian migratory flyway and demonstrated how this information can guide the site-selection process for new development. We used the random forests modeling approach to map the distribution of predicted stopover habitat for the Whooping Crane (Grus americana), an endangered species whose migratory flyway overlaps with an area where wind energy development is expected to become increasingly important. We then used this information to identify areas for potential wind power development in a U.S. state within the flyway (Nebraska) that minimize conflicts between Whooping Crane stopover habitat and the development of clean, renewable energy sources. Up to 54% of our study area was predicted to be unsuitable as Whooping Crane stopover habitat and could be considered relatively low risk for conflicts between Whooping Cranes and wind energy development. We suggest that this type of analysis be incorporated into the habitat conservation planning process in areas where incidental take permits are being considered for Whooping Cranes or other species of concern. Field surveys should always be conducted prior to construction to verify model predictions and understand baseline conditions. Prediccion y Mapeo del Habitat Potencial de Descanso de la Grulla Americana para Guiar la Seleccion de Sitios para Proyectos de Energia Eolica. Resumen Los habitats de descanso migratorio frecuentemente no son parte de la planeacion de la conservacion o proyectos de desarrollo nuevos. Identificamos habitats de descanso potenciales dentro de una via de aves migratorias y demostramos como esta informacion puede guiar en la seleccion de sitios para nuevos desarrollos. Usamos el acercamiento del modelo de bosques aleatorios para mapear la distribucion del habitat de descanso predicho de la grulla americana (Grus americana), una especie en peligro cuya via migratoria se traslapa con un area donde se espera que el desarrollo de energia eolica se vuelva cada vez mas importante. Usamos esta informacion para identificar areas para el desarrollo potencial de poder eolico en un estado de los E.U.A. dentro de la via de vuelo (Nebraska) que minimicen los conflictos entre el habitat de descanso de la grulla y el desarrollo de fuentes de energia limpias y renovables. Hasta el 54% de nuestra area de estudio fue predicha como inapropiada como un habitat de descanso para la grulla y podria considerarse como de bajo riesgo para conflictos entre las grullas y el desarrollo de energia eolica. Sugerimos que este tipo de analisis sea incorporado al proceso de planeacion de conservacion de habitat en areas donde permisos de toma incidentales estan siendo considerados para grullas americanas u otras especies de preocupacion. El muestreo en campo debera ser hecho siempre antes de la construccion para verificar las predicciones del modelo y entender las condiciones basales. C1 [Belaire, J. Amy; Minor, Emily] Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA. [Kreakie, Betty J.] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Keitt, Timothy] Univ Texas Austin, Sch Biol Sci, Austin, TX 78712 USA. RP Belaire, JA (reprint author), Univ Illinois, Dept Biol Sci, 845 W Taylor St MC 066, Chicago, IL 60607 USA. EM jbelai2@uic.edu FU National Science Foundation [DGE-0549245]; Department of Energy's National Institutes for Climate Change Research; U.S. EPA FX This study was based upon work supported by the National Science Foundation Grant DGE-0549245. We thank T. Stehn for providing information on Whooping Crane stopover locations. We also thank 2 anonymous reviewers for their thoughtful comments that greatly improved this manuscript. B.J.K. was supported by a grant to T.K. from the Department of Energy's National Institutes for Climate Change Research. This is U.S. EPA, Atlantic Ecology Division contribution ORD-003799. Although the research described in this article has been funded in part by the U.S. EPA, it has not been subjected to agency-level review. Therefore, it does not necessarily reflect the views of the agency. NR 46 TC 5 Z9 5 U1 6 U2 69 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-8892 EI 1523-1739 J9 CONSERV BIOL JI Conserv. Biol. PD APR PY 2014 VL 28 IS 2 BP 541 EP 550 DI 10.1111/cobi.12199 PG 10 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AD0KS UT WOS:000332923500025 PM 24372936 ER PT J AU Wilsey, CB Lawler, JJ Cimprich, D Schumaker, NH AF Wilsey, Chad B. Lawler, Joshua J. Cimprich, David Schumaker, Nathan H. TI Dependence of the Endangered Black-Capped Vireo on Sustained Cowbird Management SO CONSERVATION BIOLOGY LA English DT Article DE conservation-reliant; HexSim; Moluthrus ater; population model; simulation; spatially explicit; stochastic; Vireo atricapilla; conservacion dependiente; espacialmente explicito; estocastico; HexSim; modelo de poblacion; Moluthrus ater; simulacion; Vireo atricapilla ID NEST PREDATION; SPECIES-ACT; FORT-HOOD; TEXAS; POPULATION; PARASITISM; RECOVERY; SURVIVAL; BEHAVIOR; MODELS AB Conservation-reliant species depend on active management, even after surpassing recovery goals, for protection from persistent threats. Required management may include control of another species, habitat maintenance, or artificial recruitment. Sometimes, it can be difficult to determine whether sustained management is required. We used nonspatial stochastic population projection matrix simulation and a spatially explicit population model to estimate the effects of parasitism by a brood parasite, the Brown-headed Cowbird (Moluthrus ater), on a population of endangered Black-capped Vireos (Vireo atricapilla). We simulated parasitism as a percentage of breeding vireo pairs experiencing decreased fecundity due to cowbirds. We estimated maximum sustainable parasitism (i.e., highest percentage of parasitized vireo breeding pairs for which population growth is 1) with the nonspatial model under multiple scenarios designed to assess sensitivity to assumptions about population growth rate, demographic effects of parasitism, and spatial distribution of parasitism. We then used the spatially explicit model to estimate cumulative probabilities of the population falling below the population recovery target of 1000 breeding pairs for a range of parasitism rates under multiple scenarios. We constructed our models from data on vireos collected on the Fort Hood Military Reservation, Texas (U.S.A.). Estimates of maximum sustainable parasitism rates ranged from 9-12% in scenarios with a low (6%) vireo population growth rate to 49-60% in scenarios with a high (24%) growth rate. Sustained parasitism above 45-85%, depending on the scenario, would likely result in the Fort Hood Vireo population dropping below its recovery goal within the next 25 years. These estimates suggest that vireos, although tolerant of low parasitism rates, are a conservation-reliant species dependent on cowbird management. Dependencia de Vireo atricapilla, Especie en Peligro, hacia el Manejo Sostenido de Moluthurs ater Resumen Las especies dependientes de la conservacion dependen del manejo activo, incluso despues de obtener las metas de recuperacion, para la proteccion de amenazas persistentes. El manejo requerido puede incluir el control de otra especie, el mantenimiento del habitat o el reclutamiento artificial. Algunas veces puede ser dificil determinar si un manejo sostenido es requerido. Usamos una simulacion de matriz de proyeccion de poblacion estocastica y no espacial y un modelo de poblacion espacialmente explicito para estimar los efectos del parasitismo por una especie parasita de reproduccion, Moluthrus ater, sobre una poblacion de la especie en peligro Vireo atricapilla. Simulamos el parasitismo como un porcentaje de parejas de vireos que experimentan fertilidad baja debido a los M. ater. Estimamos el maximo parasitismo sostenible (p. ej.: el porcentaje mas alto de parejas reproductivas parasitadas para las cuales el crecimiento poblacional es 1) con el modelo no espacial bajo escenarios multiples asignados para estudiar la sensibilidad a los supuestos sobre la tasa de crecimiento poblacional, los efectos demograficos del parasitismo y la distribucion espacial del parasitismo. Despues utilizamos el modelo espacialmente explicito para estimar las probabilidades acumulativas de que la poblacion cayera por debajo del objetivo de recuperacion de 1000 parejas reproductivas para un rango de tasas de parasitismo bajo escenarios multiples. Construimos nuestros modelos a partir de datos de vireos colectados en la Reservacion Militar Fort Hood, Texas (E.U.A.). Los estimados de la tasa de parasitismo maximo sostenible abarcaron desde 9-12% en escenarios con una tasa baja de crecimiento poblacional (6%) de vireos hasta 49-60% en escenarios con una tasa alta de crecimiento (24%). El parasitismo sostenido por encima del 45-85%, dependiendo del escenario, probablemente resultaria en la poblacion de vireos de Fort Hood disminuyendo por debajo de su objetivo de recuperacion dentro de los siguientes 25 anos. Estos estimados sugieren que los vireos, aunque tolerantes a las tasas bajas de parasitismo, son una especie cuya conservacion depende del manejo de M. ater. C1 [Wilsey, Chad B.; Lawler, Joshua J.] Univ Washington, Coll Environm, Sch Environm & Forest Sci, Seattle, WA 98195 USA. [Cimprich, David] Ft Hood Mil Reservat, Killeen, TX 76544 USA. [Schumaker, Nathan H.] US EPA, Corvallis, OR 97333 USA. RP Wilsey, CB (reprint author), Univ Washington, Coll Environm, Sch Environm & Forest Sci, Seattle, WA 98195 USA. EM cbwilsey@uw.edu FU Strategic Environmental Research and Development Program (SERDP) [RC-1541]; U.S. Environmental Protection Agency FX This research was completed as part of the Strategic Environmental Research and Development Program (SERDP) RC-1541 project. We acknowledge the following individuals for their involvement: C. Reemts, R. Kostecke, M. Noble, S. Summers, B. Bancroft, and S. Rothstein. M. Ruckelshaus, J. Marzluff, A. Punt, and E. Main also provided valuable comments on this manuscript. The information provided in this document has been funded wholly (or in part) by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 43 TC 6 Z9 6 U1 6 U2 48 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-8892 EI 1523-1739 J9 CONSERV BIOL JI Conserv. Biol. PD APR PY 2014 VL 28 IS 2 BP 561 EP 571 DI 10.1111/cobi.12176 PG 11 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AD0KS UT WOS:000332923500027 PM 24299126 ER PT J AU Knightes, CD Golden, HE Journey, CA Davis, GM Conrads, PA Marvin-DiPasquale, M Brigham, ME Bradley, PM AF Knightes, C. D. Golden, H. E. Journey, C. A. Davis, G. M. Conrads, P. A. Marvin-DiPasquale, M. Brigham, M. E. Bradley, P. M. TI Mercury and methylmercury stream concentrations in a Coastal Plain watershed: A multi-scale simulation analysis SO ENVIRONMENTAL POLLUTION LA English DT Article DE Mercury; Exposure; Watershed; Modeling; Scale ID MASS-BALANCE; METHYL MERCURY; CONSTITUENT LOADS; HILLSLOPE SCALE; MODEL; FISH; DEPOSITION; LAKE; DYNAMICS; CANADA AB Mercury is a ubiquitous global environmental toxicant responsible for most US fish advisories. Processes governing mercury concentrations in rivers and streams are not well understood, particularly at multiple spatial scales. We investigate how insights gained from reach-scale mercury data and model simulations can be applied at broader watershed scales using a spatially and temporally explicit watershed hydrology and biogeochemical cycling model, VELMA. We simulate fate and transport using reach-scale (0.1 km(2)) study data and evaluate applications to multiple watershed scales. Reach-scale VELMA parameterization was applied to two nested sub-watersheds (28 km(2) and 25 km(2)) and the encompassing watershed (79 km(2)). Results demonstrate that simulated flow and total mercury concentrations compare reasonably to observations at different scales, but simulated methylmercury concentrations are out-of-phase with observations. These findings suggest that intricacies of methylmerculy biogeochemical cycling and transport are under-represented in VELMA and underscore the complexity of simulating mercury fate and transport. Published by Elsevier Ltd. C1 [Knightes, C. D.; Davis, G. M.] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30324 USA. [Golden, H. E.] US EPA, Off Res & Dev, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. [Journey, C. A.; Conrads, P. A.; Bradley, P. M.] US Geol Survey, South Carolina Water Sci Ctr, Columbia, SC USA. [Marvin-DiPasquale, M.] US Geol Survey, Menlo Pk, CA 94025 USA. [Brigham, M. E.] US Geol Survey, Mounds View, MN USA. RP Knightes, CD (reprint author), US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30324 USA. EM Knightes.Chris@epa.gov OI Brigham, Mark/0000-0001-7412-6800 NR 78 TC 2 Z9 2 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD APR PY 2014 VL 187 BP 182 EP 192 DI 10.1016/j.envpol.2013.12.026 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA AD8BN UT WOS:000333491600023 PM 24514076 ER PT J AU Weigand, MR Ashbolt, NJ Konstantinidis, KT Domingo, JWS AF Weigand, Michael R. Ashbolt, Nicholas J. Konstantinidis, Konstantinos T. Domingo, Jorge W. Santo TI Genome Sequencing Reveals the Environmental Origin of Enterococci and Potential Biomarkers for Water Quality Monitoring SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ESCHERICHIA-COLI; GASTROINTESTINAL ILLNESS; PATHOGENICITY ISLAND; GENETIC DIVERSITY; SOURCE TRACKING; FAECALIS; INDICATORS; PERSISTENCE; MANGANESE; INSIGHTS AB Enterococci are common members of the gut microbiome and their ease of culturing has facilitated worldwide use as indicators of fecal pollution of waters. However, enterococci were recently shown to persist in environmental habitats, often in the absence of fecal input, potentially confounding water quality assays. Toward resolving this issue and providing a more complete picture of natural enterococci diversity, 11 isolates of Enterococcus faecalis recovered from freshwater watersheds (environmental) were sequenced and compared to 59 available enteric genomes. Phenotypically and phylogenetically the environmental E. faecalis were indistinguishable from their enteric counterparts. However, distinct environmental- and enteric-associated gene signatures, encoding mostly accessory nutrient utilization pathways, were detected among the variable genes. Specifically, a nickel uptake operon was over-represented in environmental genomes, while genes for utilization of sugars thought to be abundant in the gut such as xylose were over-represented in enteric genomes. The distribution and phylogeny of these identified signatures suggest that ancestors of E. faecalis resided in extra-enteric habitats, challenging the prevailing commensal view of enterococci ecology. Thus, habitat-associated gene content changes faster than core genome phylogeny and may include biomarkers for reliably detecting fecal contaminants for improved microbial water quality monitoring. C1 [Weigand, Michael R.; Konstantinidis, Konstantinos T.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. [Ashbolt, Nicholas J.; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Cincinnati, OH 45220 USA. [Konstantinidis, Konstantinos T.] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA. [Konstantinidis, Konstantinos T.] Georgia Inst Technol, Ctr Bioinformat & Computat Genom, Atlanta, GA 30332 USA. RP Konstantinidis, KT (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. EM kostas@ce.gatech.edu; Santodomingo.Jorge@epamail.epa.gov OI Weigand, Michael/0000-0002-7278-0160 FU U.S. National Science Foundation [1241046]; U.S. Environmental Protection Agency, through its Office of Research and Development FX We thank Michael Elk and Hodon Ryu for technical assistance and discussions. This research was support in part by U.S. National Science Foundation under Award 1241046 (to K.T.K.). The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein; this work has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 51 TC 2 Z9 2 U1 4 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 1 PY 2014 VL 48 IS 7 BP 3707 EP 3714 DI 10.1021/es4054835 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AE2AQ UT WOS:000333776100014 PM 24571132 ER PT J AU Hou, WC BeigzadehMilani, S Jafvert, CT Zepp, RG AF Hou, Wen-Che BeigzadehMilani, Somayeh Jafvert, Chad T. Zepp, Richard G. TI Photoreactivity of Unfunctionalized Single-Wall Carbon Nanotubes Involving Hydroxyl Radical: Chiral Dependency and Surface Coating Effect SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LIGHT-ASSISTED OXIDATION; AQUATIC ENVIRONMENT; FUNCTIONALIZATION; WATER; FLUORESCENCE; PHOTOLUMINESCENCE; NANOPARTICLES; SUSPENSIONS; SIMULATION; REACTIVITY AB Single-wall carbon nanotubes (SWCNTs) have a variety of potential and demonstrated applications, and their production rates are increasing rapidly. This increase in production has motivated research on their transport and potential transformation and their toxicity in the environment. In this work, we examined the direct and indirect photoreactivity of SWCNTs under sunlight conditions. We found that the direct photoreactivity of pristine SWCNTs is generally low; however, indirect photoreaction involving center dot OH may be significant in natural aquatic environments. Environmental photochemical reactions generating center dot OH lead to distinct changes in SWCNT fluorescence efficiency in the near-infrared (NIR) region, Raman spectra, and light attenuation spectra in the UV, visible, and NIR regions, indicating that covalent functionalization of SWCNTs occurs. The reactivity of SWCNTs to center dot OH is dependent on the specific chiral structure of the SWCNTs and the surfactant associated with it. An operationally defined second-order rate constant (based on the decrease in NIR fluorescence signals) for all SWCNT chiral species reacting with center dot OH was estimated to be (2.91 +/- 1.30) x 10(10) M-1 s(-1). Our work suggests that photochemical reactions may be a significant transformation pathway of SWCNTs in aquatic systems. C1 [Hou, Wen-Che; Zepp, Richard G.] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Athens, GA 30605 USA. [Hou, Wen-Che] Natl Cheng Kung Univ, Dept Environm Engn, Tainan 70101, Taiwan. [BeigzadehMilani, Somayeh; Jafvert, Chad T.] Purdue Univ, Div Environm & Ecol Engn, W Lafayette, IN 47907 USA. [BeigzadehMilani, Somayeh; Jafvert, Chad T.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. RP Hou, WC (reprint author), US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Athens, GA 30605 USA. EM whou@mail.ncku.edu.tw; zepp.richard@epa.gov RI Hou, Wen-Che/F-5736-2011 OI Hou, Wen-Che/0000-0001-9884-2932 FU National Science Council (NSC) of Taiwan [NSC 102-2218-E-006-016]; Ministry of Education, Taiwan, R.O.C.; EPA STAR program [83485801] FX This article has been reviewed in accordance with the U.S. Environmental Protection Agency's (U.S. EPA) peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use by the U.S. EPA. Financial support provided by the National Science Council (NSC) of Taiwan (for W.-C. Hou) under Grant Number NSC 102-2218-E-006-016 is acknowledged. This research was, in part, supported by the Ministry of Education, Taiwan, R.O.C., The Aim for the Top University Project to the National Cheng Kung University (NCKU). Financial support (for C. T. Jafvert and S. BeigzadehMilani) provided by the EPA STAR program, Grant 83485801, is also acknowledged. NR 49 TC 14 Z9 15 U1 2 U2 49 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 1 PY 2014 VL 48 IS 7 BP 3875 EP 3882 DI 10.1021/es500013j PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AE2AQ UT WOS:000333776100034 PM 24628431 ER PT J AU Fernandez, LA Lao, WJ Maruya, KA Burgess, RM AF Fernandez, Loretta A. Lao, Wenjian Maruya, Keith A. Burgess, Robert M. TI Calculating the Diffusive Flux of Persistent Organic Pollutants between Sediments and the Water Column on the Palos Verdes Shelf Superfund Site Using Polymeric Passive Samplers SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SOLID-PHASE MICROEXTRACTION; CHLORINATED HYDROCARBONS; CONTAMINATED SEDIMENTS; PARTITION-COEFFICIENTS; PORE-WATER; CALIFORNIA; FATE; DDE; DECHLORINATION; CHEMICALS AB Passive samplers were deployed to the seafloor at a marine Superfund site on the Palos Verdes Shelf, California, USA, and used to determine water concentrations of persistent organic pollutants (POPs) in the surface sediments and near-bottom water. A model of Fickian diffusion across a thin water boundary layer at the sediment-water interface was used to calculate flux of contaminants due to molecular diffusion. Concentrations at four stations were used to calculate the flux of DDE, DDD, DDMU, and selected PCB congeners from sediments to the water column. Three passive sampling materials were compared: PE strips, POM strips, and SPME fibers. Performance reference compounds (PRCs) were used with PE and POM to correct for incomplete equilibration, and the resulting POP concentrations, determined by each material, agreed within 1 order of magnitude. SPME fibers, without PRC corrections, produced values that were generally much lower (1 to 2 orders of magnitude) than those measured using PE and POM, indicating that SPME may not have been fully equilibrated with waters being sampled. In addition, diffusive fluxes measured using PE strips at stations outside of a pilot remedial sand cap area were similar to those measured at a station inside the capped area: 240 to 260 ng cm(-2) y(-1) for p,p'-DDE. The largest diffusive fluxes of POPs were calculated at station 8C, the site where the highest sediment concentrations have been measured in the past, 1100 ng cm(-2) y(-1) for p,p'-DDE. C1 [Fernandez, Loretta A.; Burgess, Robert M.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Lao, Wenjian; Maruya, Keith A.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. RP Fernandez, LA (reprint author), US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM l.fernandez@neu.edu FU U.S. EPA, Atlantic Ecology Division, Narragansett, Rhode Island, USA FX The authors thank Fred Stern, Bill Power, Cheryl Brantley, Bill. Furlong, Chase McDonald, Chi-Li Tang, and Joe Gully of the Los Angeles County Sanitation Districts, along with Steve Gregson and Robert Harper, of RV Ocean Sentinel, for their assistance in the design, assembly, deployment, and recovery of the sampler platforms. We thank Adam Kopacsi of DCT Narragansett for his work in fabricating the sampler platforms. Mike Charpentier (Raytheon, Narragansett, RI, USA) prepared Figure 1. The authors also thank Mark Cantwell, David Katz, Wayne Munns, Ashley Parks, and Brenda Rashleigh for their insightful comments on the draft manuscript. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This report has been reviewed by the U.S. EPA's Office of Research and Development National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency. This research was performed while the first author held a National Research Council Research Associateship Award at the U.S. EPA, Atlantic Ecology Division, Narragansett, Rhode Island, USA. NR 42 TC 17 Z9 17 U1 12 U2 95 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 1 PY 2014 VL 48 IS 7 BP 3925 EP 3934 DI 10.1021/es404475c PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AE2AQ UT WOS:000333776100040 PM 24564763 ER PT J AU Ghimire, SR Johnston, JM Ingwersen, WW Hawkins, TR AF Ghimire, Santosh R. Johnston, John M. Ingwersen, Wesley W. Hawkins, Troy R. TI Life Cycle Assessment of Domestic and Agricultural Rainwater Harvesting Systems SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID IMPACT ASSESSMENT; WATER-USE; RAIN WATER; LCA; USA; URBANIZATION; ECOTOXICITY; PERSPECTIVE; MANAGEMENT; CLIMATE AB To further understanding of the environmental implications of rainwater harvesting and its water savings potential relative to conventional U.S. water delivery infrastructure, we present a method to perform life cycle assessment of domestic rainwater harvesting (DRWH) and agricultural rainwater harvesting (ARWH) systems. We also summarize the design aspects of DRWH and ARWH systems adapted to the Back Creek watershed, Virginia. The baseline design reveals that the pump and pumping electricity are the main components of DRWH and ARWH impacts. For nonpotable uses, the minimal design of DRWH (with shortened distribution distance and no pump) outperforms municipal drinking water in all environmental impact categories except ecotoxicity. The minimal design of ARWH outperforms well water in all impact categories. In terms of watershed sustainability, the two minimal designs reduced environmental impacts, from 58% to 78% energy use and 67% to 88% human health criteria pollutants, as well as avoiding up to 20% blue water (surface/groundwater) losses, compared to municipal drinking water and well water. We address potential environmental and human health impacts of urban and rural RWH systems in the region. The Building for Environmental and Economic Sustainability (BEES) model-based life cycle inventory data were used for this study. C1 [Ghimire, Santosh R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Johnston, John M.] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30605 USA. [Ingwersen, Wesley W.; Hawkins, Troy R.] US EPA, Off Res & Dev, Sustainable Technol Div, Cincinnati, OH 45268 USA. RP Johnston, JM (reprint author), US EPA, Off Res & Dev, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA. EM johnston.johnm@epa.gov OI Ingwersen, Wesley/0000-0002-9614-701X FU U.S. Environmental Protection Agency (EPA), Office of Research and Development, Athens, GA; U.S. Department of Energy [DW8992298301]; U.S. Environmental Protection Agency [DW8992298301] FX This research was supported in part by an appointment to the Postdoctoral Research Program at the U.S. Environmental Protection Agency (EPA), Office of Research and Development, Athens, GA, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW8992298301 between the U.S. Department of Energy and the U.S. Environmental Protection Agency. In addition, we thank Lourdes Prieto and Katie Price (EPA) for their help in GIS and hydrologic model data acquisition. We thank Fran Rauschenberg (Senior Environmental Employee) and Xiaobo Xue (ORISE) for technical editing and review that improved the manuscript. We thank James Evans (SRA International) for the agricultural RWH graphic in Table of Contents Art. We also thank Mike Cudahy, National Association of Home Builders, Beverly Sauer, Franklin Associates, and Jeff Church, Plastic Pipe and Fittings Association, for plastic pipe inventory development. This paper has been reviewed in accordance with Agency policy and approved for publication. The constructive comments of three anonymous reviewers improved the manuscript. The opinions expressed or statements made herein are solely those of the authors and do not necessarily reflect the views of the agencies mentioned above. Trade names or Commercial products cited do not represent an endorsement or recommendation for use. NR 59 TC 10 Z9 10 U1 3 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 1 PY 2014 VL 48 IS 7 BP 4069 EP 4077 DI 10.1021/es500189f PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AE2AQ UT WOS:000333776100057 PM 24605844 ER PT J AU Feswick, A Ankley, GT Denslow, N Ellestad, LE Fuzzen, M Jensen, KM Kroll, K Lister, A MacLatchy, DL McMaster, ME Orlando, EF Servos, MR Tetreault, GR Van Den Heuvel, MR Munkittrick, KR AF Feswick, April Ankley, Gerald T. Denslow, Nancy Ellestad, Laura E. Fuzzen, Meghan Jensen, Kathleen M. Kroll, Kevin Lister, Andrea MacLatchy, Deborah L. McMaster, Mark E. Orlando, Edward F. Servos, Mark R. Tetreault, Gerald R. Van Den Heuvel, Michael R. Munkittrick, Kelly R. TI An inter-laboratory study on the variability in measured concentrations of 17 beta-estradiol, testosterone, and 11-ketotestosterone in white sucker: Implications and recommendations SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Enzyme-linked immunosorbant assays; Interlaboratory; Radioimmunoassay; Androgens, Estrogenic compounds; Endocrine disruptors ID TANDEM MASS-SPECTROMETRY; ENDOCRINE DISRUPTING CHEMICALS; TOTAL SERUM TESTOSTERONE; KRAFT PULP-MILL; CATOSTOMUS-COMMERSONI; FATHEAD MINNOW; STEROID-LEVELS; WILD FISH; IN-VIVO; PLASMA AB Endocrine-disrupting chemicals are exogenous substances that can impact the reproduction of fish, potentially by altering circulating concentrations of 17 beta-estradiol (E2), testosterone (T), and 11-ketotestosterone (11-KT). Common methods to measure steroids in plasma samples include radioimmunoassays (RIAs) and enzyme-linked immunosorbant assays (ELISAs). The present study examines variability in E2, T, and 11-KT across 8 laboratories measuring reference and pulp mill effluent-exposed white sucker (Catostomus commersoni) plasma. We examine the contribution of assay type (RIA vs ELISA), standardized hormone extraction, location of values on the standard curve (upper and lower limits), and other variables on the ability to distinguish hormone levels between reference and exposed fish and the impact of these variables on quantitation of hormones in different laboratories. Of the 8 participating laboratories, 7 of 8 and 7 of 7 identified differences between sites for female E2 and female T, respectively, and 7 of 7 and 4 of 5 identified no differences between male T and male 11-KT. Notably, however, the ng/mL concentration of steroids measured across laboratories varied by factors of 10-, 6-, 14-, and 10-fold, respectively. Within laboratory intra-assay variability was generally acceptable and below 15%. Factors contributing to interlaboratory variability included calculation errors, assay type, and methodology. Based on the interlaboratory variability detected, we provide guidelines and recommendations to improve the accuracy and precision of steroid measurements in fish ecotoxicology studies. Environ Toxicol Chem 2014;33:847-857. (c) 2013 SETAC C1 [Feswick, April; Munkittrick, Kelly R.] Univ New Brunswick, Dept Biol, St John, NB E2L 4L5, Canada. [Ankley, Gerald T.; Jensen, Kathleen M.] US EPA, Duluth, MN USA. [Denslow, Nancy; Kroll, Kevin] Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. [Ellestad, Laura E.; Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. [Fuzzen, Meghan; Servos, Mark R.] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada. [Lister, Andrea; MacLatchy, Deborah L.] Wilfrid Laurier Univ, Dept Biol, Waterloo, ON N2L 3C5, Canada. [McMaster, Mark E.; Tetreault, Gerald R.] Environm Canada, Natl Water Res Inst, Aquat Contaminant Res Div, Burlington, ON L7R 4A6, Canada. [Van Den Heuvel, Michael R.] Univ Prince Edward Isl, Dept Biol, Charlottetown, PE C1A 4P3, Canada. RP Munkittrick, KR (reprint author), Univ New Brunswick, Dept Biol, St John, NB E2L 4L5, Canada. EM krm@unb.ca RI Servos, Mark/A-3454-2015 OI Servos, Mark/0000-0002-3783-627X FU Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs Grant; Great Lakes Action Plan FX Funding for the field portion of this project was provided by a Discovery grant from the Natural Sciences and Engineering Research Council of Canada and a Canada Research Chairs Grant to K. R. Munkittrick. It was aslso supported by Great Lakes Action Plan funding to M. E. McMaster. The laboratory analyses were supported by the individual laboratories participating in the study. NR 59 TC 7 Z9 7 U1 3 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2014 VL 33 IS 4 BP 847 EP 857 DI 10.1002/etc.2503 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AD8TO UT WOS:000333538700015 PM 24375479 ER PT J AU Griffin, SM Brinkman, NE Hedrick, EJ Rhodes, ER Fout, GS AF Griffin, Shannon M. Brinkman, Nichole E. Hedrick, Elizabeth J. Rhodes, Eric R. Fout, G. Shay TI Comparison of nucleic acid extraction and reverse transcription-qPCR approaches for detection of GI and GII noroviruses in drinking water SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Norovirus; qPCR; Molecular detection; Water ID HOLLOW-FIBER ULTRAFILTRATION; NORWALK-LIKE VIRUSES; TIME RT-PCR; WASTE-WATER; SECONDARY CONCENTRATION; VIRAL GASTROENTERITIS; SENSITIVE DETECTION; ENTERIC VIRUSES; UNITED-STATES; TAP WATER AB The objective of this study was to compare three nucleic acid extraction and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) approaches for norovirus (NoV) detection in drinking water with respect to performance, costs, and analysis time. The approaches evaluated were: (A) an approach that utilizes the QIAamp DNA Blood Mini Kit and multiplex primers and probes for detection; (B) a procedure which includes the NucliSENS Magnetic Extraction Kit and other components of a proposed European Union standard method for NoV detection in foods; and (C) a commercialized assay which uses NucliSENS extraction and Cepheid SmartCycler (R) technologies. Each approach was evaluated by most probable number (MPN) analysis for detection of GI.1 and GII.4 NoVs from human stool. Furthermore, recoveries of spiked primary effluent in tap water concentrates were compared for each approach. Few significant differences were observed between approaches with regard to performance. However, Approach C was the most time consuming and expensive to perform. This research presents a case study of how molecular-based approaches for detection of NoVs can be compared and how various factors may play a role in which approach laboratories choose to employ. Published by Elsevier B.V. C1 [Griffin, Shannon M.; Brinkman, Nichole E.; Rhodes, Eric R.; Fout, G. Shay] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Hedrick, Elizabeth J.] US EPA, Off Water, Water Secur Div, Cincinnati, OH 45268 USA. RP Griffin, SM (reprint author), US EPA, Natl Exposure Res Lab, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM griffin.shannon@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 51 TC 3 Z9 3 U1 1 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD APR PY 2014 VL 199 BP 76 EP 85 DI 10.1016/j.jviromet.2014.01.005 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA AE3CC UT WOS:000333853500012 PM 24462844 ER PT J AU Schumaker, NH Brookes, A Dunk, JR Woodbridge, B Heinrichs, JA Lawler, JJ Carroll, C LaPlante, D AF Schumaker, Nathan H. Brookes, Allen Dunk, Jeffrey R. Woodbridge, Brian Heinrichs, Julie A. Lawler, Joshua J. Carroll, Carlos LaPlante, David TI Mapping sources, sinks, and connectivity using a simulation model of northern spotted owls SO LANDSCAPE ECOLOGY LA English DT Article DE HexSim; Habitat connectivity; Net flux; Population viability analysis ID EXPLICIT POPULATION-MODELS; LANDSCAPE CONNECTIVITY; GRAPH-THEORY; CONSERVATION; DISPERSAL; HABITAT; BIOLOGY; ECOLOGY; MATRIX AB Source-sink dynamics are an emergent property of complex species-landscape interactions. A better understanding of how human activities affect source-sink dynamics has the potential to inform and improve the management of species of conservation concern. Here we use a study of the northern spotted owl (Strix occidentalis caurina) to introduce new methods for quantifying source-sink dynamics that simultaneously describe the population-wide consequences of changes to landscape connectivity. Our spotted owl model is mechanistic, spatially-explicit, individual-based, and incorporates competition with barred owls (Strix varia). Our observations of spotted owl source-sink dynamics could not have been inferred solely from habitat quality, and were sensitive to landscape connectivity and the spatial sampling schemes employed by the model. We conclude that a clear understanding of source-sink dynamics can best be obtained from sampling simultaneously at multiple spatial scales. Our methodology is general, can be readily adapted to other systems, and will work with population models ranging from simple and low-parameter to complex and data-intensive. C1 [Schumaker, Nathan H.; Brookes, Allen] US EPA, Corvallis, OR 97333 USA. [Dunk, Jeffrey R.] Humboldt State Univ, Dept Environm Sci & Management, Arcata, CA 95521 USA. [Woodbridge, Brian] US Fish & Wildlife Serv, Yreka Fish & Wildlife Off, Yreka, CA 96097 USA. [Heinrichs, Julie A.; Lawler, Joshua J.] Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA. [Carroll, Carlos] Klamath Ctr Conservat Res, Orleans, CA 95556 USA. [LaPlante, David] Nat Resources Geospatial, Montague, CA 96064 USA. RP Schumaker, NH (reprint author), US EPA, 200 SW 35th St, Corvallis, OR 97333 USA. EM nathan.schumaker@gmail.com RI Heinrichs, Julie/D-2927-2016 OI Heinrichs, Julie/0000-0001-7733-5034 FU USFWS [134250BJ151, F12AC01135]; Strategic Environmental Research and Development Program [RC-1541, RC-2120]; U.S. Environmental Protection Agency FX Our NSO simulation model could not have been developed without the invaluable assistance generously provided by Robert Anthony, Katie Dugger, Paul Henson, Brendon White, and Betsy Glenn. We are indebted to Robert Schooley, Barry Noon, and an anonymous reviewer for many detailed suggestions that greatly improved the manuscript. This work was supported in part by USFWS Agreements 134250BJ151 and F12AC01135 to JRD, and grants RC-1541 and RC-2120 to JL from the Strategic Environmental Research and Development Program. The information in this document has been funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 41 TC 12 Z9 12 U1 1 U2 76 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 EI 1572-9761 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD APR PY 2014 VL 29 IS 4 BP 579 EP 592 DI 10.1007/s10980-014-0004-4 PG 14 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AD8RR UT WOS:000333533800003 ER PT J AU Huber, PR Greco, SE Schumaker, NH Hobbs, J AF Huber, Patrick R. Greco, Steven E. Schumaker, Nathan H. Hobbs, Joe TI A priori assessment of reintroduction strategies for a native ungulate: using HexSim to guide release site selection SO LANDSCAPE ECOLOGY LA English DT Article DE SEPM; Population modeling; Tule elk; Human-wildlife conflict; Movement modeling; Grasslands Ecological Area ID POPULATION-DYNAMICS; TULE ELK; HABITAT; CALIFORNIA; VIABILITY; IMPACTS; BIOLOGY; MODEL; RED AB Reintroduction of native species to unoccupied portions of their historical range is a common management strategy to enhance the future viability of animal populations. This approach has met with mixed success, due to unforeseen impacts caused by human or other factors. Some of these impacts could potentially be mitigated through the use of anticipatory modeling coupled with appropriate management strategies prior to release. As part of an ongoing restoration program, we evaluated a portion of the former range of the tule elk (Cervus elaphus nannodes) in the Central Valley of California for potential reintroduction of a free-ranging herd. We used a new spatially explicit population model (HexSim) to analyze four different elk release scenarios. Each scenario corresponded to a different release location, and the model was used to compare simulated elk movement and population dynamics 25 years into the future. We also used HexSim to identify likely locations of human-elk conflict. Population forecasts after the 25-year period were highest (mean female population size of 169.6 per iteration) and potentially harmful barrier interactions were lowest (mean 8.6 per iteration) at the East Bear Creek site. These results indicate the East Bear Creek site release scenario as the most likely to result in a successful elk reintroduction, producing the most elk and generating the fewest human conflicts. We found HexSim to be a useful tool for this type of reintroduction planning and believe that other reintroduction efforts could benefit from this type of anticipatory modeling. C1 [Huber, Patrick R.; Greco, Steven E.] Univ Calif Davis, Davis, CA 95616 USA. [Schumaker, Nathan H.] US EPA, Corvallis, OR 97333 USA. [Hobbs, Joe] Calif Dept Fish & Wildlife, Sacramento, CA 95811 USA. RP Huber, PR (reprint author), Univ Calif Davis, One Shields Ave, Davis, CA 95616 USA. EM prhuber@ucdavis.edu FU Rocky Mountain Elk Foundation; U.S. Fish and Wildlife Service; California Department of Fish and Wildlife; U.S. Environmental Protection Agency FX We wish to thank the Rocky Mountain Elk Foundation and U.S. Fish and Wildlife Service for their generous financial support of this project. We also wish to thank the California Department of Fish and Wildlife for their support and valuable expertise. The information in this document has been funded wholly (or in part) by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 29 TC 3 Z9 3 U1 3 U2 47 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 EI 1572-9761 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD APR PY 2014 VL 29 IS 4 BP 689 EP 701 DI 10.1007/s10980-014-0006-2 PG 13 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AD8RR UT WOS:000333533800011 ER PT J AU Gonzalez-Mejia, AM Eason, TN Cabezas, H Suidan, MT AF Gonzalez-Mejia, Alejandra M. Eason, Tarsha N. Cabezas, Heriberto Suidan, Makram T. TI Social and economic sustainability of urban systems: comparative analysis of metropolitan statistical areas in Ohio, USA SO SUSTAINABILITY SCIENCE LA English DT Article DE Fisher Information index; Sustainability indicator/metric; Metropolitan statistical areas; Urban system dynamics ID FISHER INFORMATION; REGIME CHANGES; ECOLOGICAL-SYSTEMS; INDEXES AB The development of a comprehensive sustainability analysis tool for evaluating regional urban systems would present researchers, planners, and policy makers with a powerful tool to study and manage systems, with the goal of encouraging optimum social and economic trends, while maintaining long-term environmental protection that leads to sustainability. This article intends to aid in this effort by presenting a versatile methodology for assessing sustainability as a function of dynamic changes in significant characteristics of urban systems. Using statistical methods, this work presents a strategy for comparatively assessing the impact of social and economic characteristics on system stability at geographic scales which are critical to policy and management. Specifically, it employs the Fisher Information index as a measure of sustainability, in order to distinguish periods of stability. As an application of the approach, six Metropolitan Statistical Areas (MSAs) in Ohio (Cincinnati, Dayton, Cleveland, Akron, Columbus, and Toledo) were evaluated for a regional sustainability assessment. Results from the multiyear analysis suggest two distinct periods in these MSAs: one characterized by 30 years of socio-economic growth (1970-1999) and another (2000-2009) denoting a change in the trajectory of each system found to be related to economic recession. Columbus was identified as the most stable and sustainable of the MSAs during the study period. In contrast, Toledo exhibited the largest changes in economic trends, as distinguished by excessive increases in the growth rate of vacant housing units, unemployed civilian labor force, and inhabitants below the poverty level (2000-2009). Since such conditions are not desirable for urban systems, they are indicative of movement towards an unsustainable future. C1 [Gonzalez-Mejia, Alejandra M.; Suidan, Makram T.] Univ Cincinnati, Coll Engn & Appl Sci, Environm Program, Cincinnati, OH 45221 USA. [Gonzalez-Mejia, Alejandra M.; Eason, Tarsha N.; Cabezas, Heriberto] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Suidan, MT (reprint author), Amer Univ Beirut, Fac Engn & Architecture, Bechtel Engn Bldg, Beirut, Lebanon. EM gonzalai@mail.uc.edu; eason.tarsha@epa.gov; cabezas.heriberto@epa.gov; makram.suidan@uc.edu NR 41 TC 3 Z9 4 U1 0 U2 24 PU SPRINGER JAPAN KK PI TOKYO PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065, JAPAN SN 1862-4065 EI 1862-4057 J9 SUSTAIN SCI JI Sustain. Sci. PD APR PY 2014 VL 9 IS 2 BP 217 EP 228 DI 10.1007/s11625-013-0227-3 PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA AD8OL UT WOS:000333525400009 ER PT J AU Kazgan, N Metukuri, MR Purushotham, A Lu, J Rao, A Lee, S Pratt-Hyatt, M Lickteig, A Csanaky, IL Zhao, YM Dawson, PA Li, XL AF Kazgan, Nevzat Metukuri, Mallikarjuna R. Purushotham, Aparna Lu, Jing Rao, Anuradha Lee, Sangkyu Pratt-Hyatt, Matthew Lickteig, Andrew Csanaky, Ivan L. Zhao, Yingming Dawson, Paul A. Li, Xiaoling TI Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2-HNF-1 alpha-FXR Signaling and Alters Systemic Bile Acid Homeostasis SO GASTROENTEROLOGY LA English DT Article DE Ileal Bile Acid Absorption; Bile Acid Synthesis; Liver Damage; Cholestasis ID FARNESOID-X-RECEPTOR; NUCLEAR RECEPTOR; PROTEIN DEACETYLASES; MAMMALIAN SIRTUINS; METABOLIC SYNDROME; ENERGY-METABOLISM; FXR; CHOLESTEROL; ACETYLATION; EXPRESSION AB BACKGROUND & AIMS: Sirtuin 1 (SIRT1), the most conserved mammalian oxidized nicotinamide adenine dinucleotide-dependent protein deacetylase, is an important metabolic sensor in many tissues. However, little is known about its role in the small intestine, which absorbs and senses nutrients. We investigated the functions of intestinal SIRT1 in systemic bile acid and cholesterol metabolism in mice. METHODS: SIRT1 was specifically deleted from the intestines of mice using the flox-Villin-Cre system (SIRT1 iKO mice). Intestinal and hepatic tissues were collected, and bile acid absorption was analyzed using the everted gut sac experiment. Systemic bile acid metabolism was studied in SIRT1 iKO and flox control mice placed on standard diets, diets containing 0.5% cholic acid or 1.25% cholesterol, or lithogenic diets. RESULTS: SIRT1 iKO mice had reduced intestinal farnesoid X receptor (FXR) signaling via hepatocyte nuclear factor 1 alpha (HNF-1 alpha) compared with controls, which reduced expression of the bile acid transporter genes Asbt and Mcf2l (encodes Ost) and absorption of ileal bile acids. SIRT1 regulated HNF-1 alpha/FXR signaling partially through dimerization cofactor of HNF-1 alpha (Dcoh2) Dcoh2, which increases dimerization of HNF-1 alpha. SIRT1 was found to deacetylate Dcoh2, promoting its interaction with HNF-1 alpha and inducing DNA binding by HNF-1 alpha. Intestine-specific deletion of SIRT1 increased hepatic bile acid biosynthesis, reduced hepatic accumulation of bile acids, and protected animals from liver damage from a diet high in levels of bile acids. CONCLUSIONS: Intestinal SIRT1, a key nutrient sensor, is required for ileal bile acid absorption and systemic bile acid homeostasis in mice. We delineated the mechanism of metabolic regulation of HNF-1 alpha/FXR signaling. Reagents designed to inhibit intestinal SIRT1 might be developed to treat bile acid-related diseases such as cholestasis. C1 [Kazgan, Nevzat; Metukuri, Mallikarjuna R.; Purushotham, Aparna; Lu, Jing; Li, Xiaoling] Natl Inst Environm Hlth Sci, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA. [Rao, Anuradha; Dawson, Paul A.] Wake Forest Sch Med, Dept Internal Med, Gastroenterol Sect, Winston Salem, NC USA. [Lee, Sangkyu; Zhao, Yingming] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA. [Pratt-Hyatt, Matthew; Lickteig, Andrew; Csanaky, Ivan L.] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA. RP Li, XL (reprint author), Natl Inst Environm Hlth Sci, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA. EM lix3@niehs.nih.gov RI Csanaky, Ivan/N-5312-2015; OI Csanaky, Ivan/0000-0001-7870-4129; Pratt-Hyatt, Matthew/0000-0001-5532-9725 FU National Institute of Environmental Health Sciences, National Institutes of Health (NIH) [Z01 ES102205]; National Institute of Diabetes and Digestive and Kidney Diseases, NIH [DK047987]; National Cancer Institute, NIH [CA126832]; NIH grant [R01ES009649] FX Supported by grants from the Intramural Research Program of the National Institute of Environmental Health Sciences, National Institutes of Health (NIH) (Z01 ES102205 to X. L.); the National Institute of Diabetes and Digestive and Kidney Diseases, NIH (DK047987 to P. A. D.); and the National Cancer Institute, NIH (CA126832 to Y.Z.) and a NIH grant (R01ES009649) to Curtis Klaassen, University of Kansas. NR 37 TC 12 Z9 12 U1 0 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 2014 VL 146 IS 4 BP 1006 EP 1016 DI 10.1053/j.gastro.2013.12.029 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AD4XH UT WOS:000333254500030 PM 24389307 ER PT J AU Jolliet, O Frischknecht, R Bare, J Boulay, AM Bulle, C Fantke, P Gheewala, S Hauschild, M Itsubo, N Margni, M McKone, T Canals, LMY Postuma, L Prado-Lopez, V Ridoutt, B Sonnemann, G Rosenbaum, RK Seager, T Struijs, J van Zelm, R Vigon, B Weisbrod, A AF Jolliet, Olivier Frischknecht, Rolf Bare, Jane Boulay, Anne-Marie Bulle, Cecile Fantke, Peter Gheewala, Shabbir Hauschild, Michael Itsubo, Norihiro Margni, Manuele McKone, Thomas E. Mila y Canals, Llorenc Postuma, Leo Prado-Lopez, Valentina Ridoutt, Brad Sonnemann, Guido Rosenbaum, Ralph K. Seager, Tom Struijs, Jaap van Zelm, Rosalie Vigon, Bruce Weisbrod, Annie TI Global guidance on environmental life cycle impact assessment indicators: findings of the scoping phase SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT LA English DT Article ID FRAMEWORK C1 [Jolliet, Olivier] Univ Michigan, Sch Publ Hlth Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Frischknecht, Rolf] Treeze Ltd, Uster, Switzerland. [Bare, Jane] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Syst Anal Branch, Cincinnati, OH 45268 USA. [Boulay, Anne-Marie; Bulle, Cecile; Margni, Manuele] Ecole Polytech, CIRAIG, Montreal, PQ H3C 3A7, Canada. [Fantke, Peter; Hauschild, Michael; Rosenbaum, Ralph K.] Tech Univ Denmark, Dept Engn Management, DK-2800 Lyngby, Denmark. [Gheewala, Shabbir] King Mongkuts Univ Technol, Joint Grad Sch Energy & Environm, Thonburi, Thailand. [Itsubo, Norihiro] Tokyo City Univ, Yokohama, Kanagawa, Japan. [McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Mila y Canals, Llorenc] Unilever, Safety & Environm Assurance Ctr, Sharnbrook, Beds, England. [Mila y Canals, Llorenc] United Nations Environm Programme, Div Technol Ind & Econ, Paris, France. [Postuma, Leo; Struijs, Jaap] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Prado-Lopez, Valentina; Seager, Tom] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA. [Ridoutt, Brad] CSIRO, Sustainable Agr Natl Res Flagship, Clayton, Vic, Australia. [Sonnemann, Guido] Univ Bordeaux, ISM, UMR 5255, Bordeaux, France. [van Zelm, Rosalie] Radboud Univ Nijmegen, Dept Environm Sci, NL-6525 ED Nijmegen, Netherlands. [Vigon, Bruce] SETAC, Pensacola, FL USA. [Weisbrod, Annie] Procter & Gamble, Cincinnati, OH USA. RP Jolliet, O (reprint author), Univ Michigan, Sch Publ Hlth Environm Hlth Sci, Ann Arbor, MI 48109 USA. EM ojolliet@umich.edu RI van Zelm, Rosalie/D-4108-2011; QSA, DTU/J-4787-2014; Hauschild, Michael/G-4335-2011; Ridoutt, Bradley/D-3329-2011; Fantke, Peter/N-2704-2015; OI Hauschild, Michael Zwicky/0000-0002-8331-7390; Ridoutt, Bradley/0000-0001-7352-0427; Fantke, Peter/0000-0001-7148-6982; Rosenbaum, Ralph/0000-0002-7620-1568; Posthuma, Leo/0000-0003-0399-5499; Gheewala, Shabbir/0000-0002-4300-1551 FU UNEP/SETAC Life Cycle Initiative FX The authors acknowledge the contributions from the participants of the Glasgow workshop and the UNEP/SETAC Life Cycle Initiative for funding this activity. NR 12 TC 23 Z9 23 U1 2 U2 24 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0948-3349 EI 1614-7502 J9 INT J LIFE CYCLE ASS JI Int. J. Life Cycle Assess. PD APR PY 2014 VL 19 IS 4 BP 962 EP 967 DI 10.1007/s11367-014-0703-8 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AD4FX UT WOS:000333204500023 ER PT J AU Schroeter, JD Campbell, J Kimbell, JS Conolly, RB Clewell, HJ Andersen, ME AF Schroeter, Jeffry D. Campbell, Jerry Kimbell, Julia S. Conolly, Rory B. Clewell, Harvey J. Andersen, Melvin E. TI Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formaldehyde Dosimetry Predictions in the Rat, Monkey, and Human Nasal Passages SO TOXICOLOGICAL SCIENCES LA English DT Article DE formaldehyde; endogenous; nasal; computational fluid dynamics; pharmacokinetics ID COMPUTATIONAL FLUID-DYNAMICS; INSPIRATORY AIR-FLOW; PROTEIN CROSS-LINKS; RHESUS-MONKEYS; RESPIRATORY-TRACT; F344 RAT; COMPUTER-SIMULATION; INHALATION EXPOSURE; CELL-PROLIFERATION; COVALENT BINDING AB Formaldehyde is a nasal carcinogen in rodents at high doses and is an endogenous compound that is present in all living cells. Due to its high solubility and reactivity, quantitative risk estimates for inhaled formaldehyde have relied on internal dose estimates in the upper respiratory tract. Dosimetry calculations are complicated by the presence of endogenous formaldehyde concentrations in the respiratory mucosa. Anatomically accurate computational fluid dynamics (CFD) models of the rat, monkey, and human nasal passages were used to simulate uptake of inhaled formaldehyde. An epithelial structure was implemented in the nasal CFD models to estimate formaldehyde absorption from air:tissue partitioning, species-specific metabolism, first-order clearance, DNA binding, and endogenous formaldehyde production. At an exposure concentration of 1 ppm, predicted formaldehyde nasal uptake was 99.4, 86.5, and 85.3% in the rat, monkey, and human, respectively. Endogenous formaldehyde in nasal tissues did not significantly affect wall mass flux or nasal uptake predictions at exposure concentrations > 500 ppb; however, reduced nasal uptake was predicted at lower exposure concentrations. At an exposure concentration of 1 ppb, predicted nasal uptake was 17.5 and 42.8% in the rat and monkey; net desorption of formaldehyde was predicted in the human model. The nonlinear behavior of formaldehyde nasal absorption will affect the dose-response analysis and subsequent risk estimates at low exposure concentrations. Updated surface area partitioning of nonsquamous epithelium and average flux values in regions where DNA-protein cross-links and cell proliferation rates were measured in rats and monkeys are reported for use in formaldehyde risk models of carcinogenesis. C1 [Schroeter, Jeffry D.] Appl Res Associates Inc, Raleigh, NC 27615 USA. [Campbell, Jerry; Clewell, Harvey J.; Andersen, Melvin E.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA. [Kimbell, Julia S.] Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA. [Conolly, Rory B.] US EPA, Integrated Syst Toxicol Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA. RP Schroeter, JD (reprint author), Appl Res Associates Inc, 8537 Six Forks Rd,Suite 600, Raleigh, NC 27615 USA. EM jschroeter@ara.com OI Andersen, Melvin/0000-0002-3894-4811 FU Research Foundation for Health and Environmental Effects FX Research Foundation for Health and Environmental Effects. NR 44 TC 12 Z9 12 U1 2 U2 13 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD APR PY 2014 VL 138 IS 2 BP 412 EP 424 DI 10.1093/toxsci/kft333 PG 13 WC Toxicology SC Toxicology GA AD5LE UT WOS:000333293500016 PM 24385418 ER PT J AU Geter, DR Bhat, VS Gollapudi, BB Sura, R Hester, SD AF Geter, David R. Bhat, Virunya S. Gollapudi, B. Bhaskar Sura, Radhakrishna Hester, Susan D. TI Dose-Response Modeling of Early Molecular and Cellular Key Events in the CAR-Mediated Hepatocarcinogenesis Pathway SO TOXICOLOGICAL SCIENCES LA English DT Article DE phenobarbital; hepatocellular proliferation; dose-response; benchmark dose ID CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR; UDP-GLUCURONOSYLTRANSFERASE INDUCERS; PROLIFERATOR-ACTIVATED RECEPTORS; MICROSOMAL-ENZYME INDUCERS; DRUG-METABOLIZING-ENZYMES; RISK-ASSESSMENT; ANDROSTANE RECEPTOR; NUCLEAR RECEPTORS; MOUSE HEPATOCARCINOGENESIS; TUMOR SUSCEPTIBILITY AB Low-dose extrapolation and dose-related transitions are paramount in the ongoing debate regarding the quantification of cancer risks for nongenotoxic carcinogens. Phenobarbital (PB) is a prototypical nongenotoxic carcinogen that activates the constitutive androstane receptor (CAR) resulting in rodent liver tumors. In this study, male and female CD-1 mice administered dietary PB at 0, 0.15, 1.5, 15, 75, or 150 mg/kg-day for 2 or 7 days to characterize multiple apical and molecular endpoints below, at (similar to 75 mg/kg-day), and above the carcinogenic dose level of PB and examine these responses using benchmark dose modeling. Linear toxicokinetics were observed for all doses. Increased liver weight, hepatocellular hypertrophy, and mitotic figures were seen at 75 and 150 mg/kg-day. CAR activation, based on Cyp2b qPCR and pentoxyresorufin dealkylase activity, occurred at doses >= 1.5 mg/kg-day. The no-observable transcriptional effect level for global gene expression was 15 mg/kg-day. At 2 days, several xenobiotic metabolism and cell protective pathways were activated at lower doses and to a greater degree in females. However, hepatocellular proliferation, quantified by bromodeoxyuridine immunohistochemistry, was the most sensitive indicator of PB exposure with female mice more sensitive than males, contrary to sex-specific differences in sensitivity to hepatocarcinogenesis. Taken together, the identification of low-dose cellular and molecular transitions in the subtumorigenic dose range aids the understanding of early key events in CAR-mediated hepatocarcinogenesis. C1 [Geter, David R.; Gollapudi, B. Bhaskar; Sura, Radhakrishna] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. [Bhat, Virunya S.] Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA. [Hester, Susan D.] US EPA, Res Triangle Pk, NC 27711 USA. RP Hester, SD (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, B105-03,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM hester.susan@epa.gov NR 74 TC 13 Z9 14 U1 0 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD APR PY 2014 VL 138 IS 2 BP 425 EP 445 DI 10.1093/toxsci/kfu014 PG 21 WC Toxicology SC Toxicology GA AD5LE UT WOS:000333293500017 PM 24449422 ER PT J AU Maynard, JJ Dahlgren, RA O'Geen, AT AF Maynard, Jonathan J. Dahlgren, Randy A. O'Geen, Anthony T. TI Autochthonous and Allochthonous Carbon Cycling in a Eutrophic Flow-Through Wetland SO WETLANDS LA English DT Article DE Carbon cycling; Aquatic metabolism; Autochthonous carbon; Allochthonous carbon; Constructed wetlands; Primary productivity; Eutrophication; Water quality ID RECEIVING AGRICULTURAL RUNOFF; NONPOINT-SOURCE POLLUTION; DISSOLVED ORGANIC-CARBON; SAN-JOAQUIN VALLEY; AQUATIC FOOD WEBS; CONSTRUCTED WETLANDS; ECOSYSTEM METABOLISM; TERRESTRIAL SUPPORT; C-13 ADDITION; OXYGEN-DEMAND AB Wetland environments are important sites for the cycling and retention of terrestrially derived organic matter and nutrients. Wetland treatment of agricultural runoff has been shown to improve water quality and promote carbon sequestration. However, the potential role of eutrophic wetlands as a source of algal loading contributing to downstream hypoxia has prompted interest in understanding algal productivity and export from these systems. This study, in the San Joaquin Valley, California, quantified a mass balance of carbon and nutrients within a seasonally-saturated constructed wetland receiving agricultural runoff, as well as quantifying autochthonous carbon production on four sampling dates during a year with minimal emergent vegetation. Results from this study show that the wetland was a net-sink for nutrients and particulate/dissolved organic carbon. Despite high concentrations of inflowing nutrients and high rates of primary productivity, high respiration rates limited net organic C production and export due to high heterotrophic activity. The addition of high C loads in inflowing water and moderate retention efficiencies, however, resulted in a positive C retention during most sampling dates. This study provides valuable insight into the connection between elevated carbon and nutrient inflows, their effects on autochthonous carbon production, and resulting carbon and nutrient outflows. C1 [Maynard, Jonathan J.] US EPA, Corvallis, OR 97333 USA. [Dahlgren, Randy A.; O'Geen, Anthony T.] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95618 USA. RP Maynard, JJ (reprint author), NMSU, USDA ARS Jornada Expt Range, MSC 3 JER,Box 30003, Las Cruces, NM 88003 USA. EM jmaynard@nmsu.edu FU California State Water Resources Control Board; Kearney Foundation of Soil Science FX Funding for this project was provided through an agreement with the California State Water Resources Control Board and the Kearney Foundation of Soil Science. The information in this document has been subjected to review by the US Environmental Protection Agency and approved for publication. The contents of this document do not necessarily reflect the views and policies of the California State Water Resources Control Board or the US Environmental Protection Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. We would like to thank Mickey Saso for his cooperation and support. We would also like to thank James Chang and Jiayou Deng for help with field sampling and laboratory analysis. NR 56 TC 1 Z9 1 U1 7 U2 38 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD APR PY 2014 VL 34 IS 2 BP 285 EP 296 DI 10.1007/s13157-013-0474-1 PG 12 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA AC9AE UT WOS:000332825400009 ER PT J AU Fay, KA Fitzsimmons, PN Hoffman, AD Nichols, JW AF Fay, Kellie A. Fitzsimmons, Patrick N. Hoffman, Alex D. Nichols, John W. TI Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish SO XENOBIOTICA LA English DT Article DE Bioaccumulation assessment; hepatocellularity; hepatocytes; intrinsic clearance; in vitro-in vivo extrapolation; trout ID FRESHLY ISOLATED HEPATOCYTES; XENOBIOTIC INTRINSIC CLEARANCE; METABOLIZING ENZYME-ACTIVITIES; ONCORHYNCHUS-MYKISS; SALMO-GAIRDNERI; FUNCTIONAL UNITS; PRIMARY CULTURE; LIVER; RAT; HEPATOCELLULARITY AB Biotransformation rates measured using cryopreserved trout hepatocytes can be extrapolated to the whole animal to predict metabolism impacts on chemical bioaccumulation. Future use of these methods within a regulatory context requires, however, that they be optimized and standardized. Specifically, questions exist concerning gender differences in metabolism, cryopreservability of cells, and the accuracy of in vitro-in vivo scaling factors. 2. In this study, we evaluated hepatocytes from juvenile male and female trout. No gender differences in cell size, protein abundance, cytochrome P450 content, ethoxyresorufin-O-deethylase activity, uridine diphosphate glucuronosyltransferase activity or intrinsic clearance of pyrene were observed for freshly isolated hepatocytes. There was a small difference in measured glutathione-S-transferase activity (<25%; males > females). 3. Cells were cryopreserved by two methods: direct placement into liquid N-2 vapor and controlled, slow-rate freezing. Comparable live recovery and enzymatic activity were observed regardless of freezing method or gender. Cells cryopreserved in liquid N-2 vapor exhibited activity levels similar to those of freshly isolated cells, although there were small but significant differences in pyrene clearance and glutathione-S-transferase activity (frozen < fresh). Hepatocellularity values did not differ by sex. 4. These results suggest that hepatocytes from male and female juvenile trout may be used interchangeably for in vitro-in vivo metabolism extrapolations. C1 [Fay, Kellie A.; Fitzsimmons, Patrick N.; Hoffman, Alex D.; Nichols, John W.] US EPA, Div Midcontinent Ecol, ORD, NHEERL, Duluth, MN 55804 USA. RP Fay, KA (reprint author), US EPA, Div Midcontinent Ecol, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM fay.kellie@epa.gov NR 36 TC 3 Z9 3 U1 0 U2 15 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0049-8254 EI 1366-5928 J9 XENOBIOTICA JI Xenobiotica PD APR PY 2014 VL 44 IS 4 BP 345 EP 351 DI 10.3109/00498254.2013.845704 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AC7UR UT WOS:000332738200006 PM 24138324 ER PT J AU Hall, RK Guiliano, D Swanson, S Philbin, MJ Lin, J Aron, JL Schafer, RJ Heggem, DT AF Hall, Robert K. Guiliano, David Swanson, Sherman Philbin, Michael J. Lin, John Aron, Joan L. Schafer, Robin J. Heggem, Daniel T. TI An ecological function and services approach to total maximum daily load (TMDL) prioritization SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Ecosystem function; Water quality; TMDL; Non-point source; Riparian PFC AB Prioritizing total maximum daily load (TMDL) development starts by considering the scope and severity of water pollution and risks to public health and aquatic life. Methodology using quantitative assessments of in-stream water quality is appropriate and effective for point source (PS) dominated discharge, but less so in watersheds with mostly nonpoint source (NPS) related impairments. For NPSs, prioritization in TMDL development and implementation of associated best management practices should focus on restoration of ecosystem physical functions, including how restoration effectiveness depends on design, maintenance and placement within the watershed. To refine the approach to TMDL development, regulators and stakeholders must first ask if the watershed, or ecosystem, is at risk of losing riparian or other ecologically based physical attributes and processes. If so, the next step is an assessment of the spatial arrangement of functionality with a focus on the at-risk areas that could be lost, or could, with some help, regain functions. Evaluating stream and wetland riparian function has advantages over the traditional means of water quality and biological assessments for NPS TMDL development. Understanding how an ecosystem functions enables stakeholders and regulators to determine the severity of problem(s), identify source(s) of impairment, and predict and avoid a decline in water quality. The Upper Reese River, Nevada, provides an example of water quality impairment caused by NPS pollution. In this river basin, stream and wetland riparian proper functioning condition (PFC) protocol, water quality data, and remote sensing imagery were used to identify sediment sources, transport, distribution, and its impact on water quality and aquatic resources. This study found that assessments of ecological function could be used to generate leading (early) indicators of water quality degradation for targeting pollution control measures, while traditional in-stream water quality monitoring lagged in response to the deterioration in ecological functions. C1 [Hall, Robert K.; Guiliano, David] USEPA Reg IX, San Francisco, CA 94105 USA. [Swanson, Sherman] Univ Nevada, Reno, NV 89557 USA. [Philbin, Michael J.] US Dept Interior Bur Land Management, Montana Dakotas State Off, Billings, MT USA. [Lin, John] US EPA, Off Res & Dev, NERL, ESD,Landscape Ecol Branch, Las Vegas, NV USA. [Aron, Joan L.] Aron Environm Consulting, Columbia, MD USA. [Schafer, Robin J.] Univ Puerto Rico, San Juan, PR 00936 USA. [Heggem, Daniel T.] US EPA, Off Res & Dev, NERL, Div Environm Sci, Las Vegas, NV USA. RP Hall, RK (reprint author), USEPA Reg IX, WTR2,75 Hawthorne St, San Francisco, CA 94105 USA. EM hall.robertk@epa.gov OI Heggem, Daniel/0000-0001-9238-3368 FU United States Environmental Protection Agency through Office of Research and Development FX The authors thank the local ranchers in the Upper Reese River Basin, and especially the efforts of Kenneth Smith and Dr. Bonnie Bobb. We also like to thank Janice Staats (BLM), Randy Pahl (NDEP), Maliha Nash (USEPA), Cindy Lin (USEPA), and Douglas Norton (USEPA) for their critical review of this manuscript. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. NR 34 TC 5 Z9 5 U1 3 U2 56 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD APR PY 2014 VL 186 IS 4 BP 2413 EP 2433 DI 10.1007/s10661-013-3548-x PG 21 WC Environmental Sciences SC Environmental Sciences & Ecology GA AB9YE UT WOS:000332150800036 PM 24435289 ER PT J AU Levine, CR Yanai, RD Lampman, GG Burns, DA Driscoll, CT Lawrence, GB Lynch, JA Schoch, N AF Levine, Carrie R. Yanai, Ruth D. Lampman, Gregory G. Burns, Douglas A. Driscoll, Charles T. Lawrence, Gregory B. Lynch, Jason A. Schoch, Nina TI Evaluating the efficiency of environmental monitoring programs SO ECOLOGICAL INDICATORS LA English DT Article DE Uncertainty; Long-term; Lakes; Monitoring; Streams; Loons; Biomass ID NORTHEASTERN UNITED-STATES; NEW-YORK; ACIDIC DEPOSITION; ADIRONDACK REGION; FOREST; ECOSYSTEMS; MERCURY; CARBON; LAKES; UNCERTAINTY AB Statistical uncertainty analyses can be used to improve the efficiency of environmental monitoring, allowing sampling designs to maximize information gained relative to resources required for data collection and analysis. In this paper, we illustrate four methods of data analysis appropriate to four types of environmental monitoring designs. To analyze a long-term record from a single site, we applied a general linear model to weekly stream chemistry data at Biscuit Brook, NY, to simulate the effects of reducing sampling effort and to evaluate statistical confidence in the detection of change over time. To illustrate a detectable difference analysis, we analyzed a one-time survey of mercury concentrations in loon tissues in lakes in the Adirondack Park, NY, demonstrating the effects of sampling intensity on statistical power and the selection of a resampling interval. To illustrate a bootstrapping method, we analyzed the plot-level sampling intensity of forest inventory at the Hubbard Brook Experimental Forest, NH, to quantify the sampling regime needed to achieve a desired confidence interval. Finally, to analyze time-series data from multiple sites, we assessed the number of lakes and the number of samples per year needed to monitor change over time in Adirondack lake chemistry using a repeated-measures mixed-effects model. Evaluations of time series and synoptic long-term monitoring data can help determine whether sampling should be re-allocated in space or time to optimize the use of financial and human resources. (C) 2014 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Levine, Carrie R.; Yanai, Ruth D.] SUNY Coll Environm Sci & Forestry, Dept Forest & Nat Resources Management, Syracuse, NY 13210 USA. [Lampman, Gregory G.] New York State Energy Res & Dev Author, New York, NY 12203 USA. [Burns, Douglas A.; Lawrence, Gregory B.] US Geol Survey, Troy, NY 12180 USA. [Driscoll, Charles T.] Syracuse Univ, Dept Civil & Environm Engn, Syracuse, NY 13244 USA. [Lynch, Jason A.] US EPA, Clean Air Markets Div, Washington, DC 20460 USA. [Schoch, Nina] Biodivers Res Inst, Gorham, ME 04038 USA. RP Levine, CR (reprint author), Univ Calif Berkeley, Dept Environm Sci Policy & Management, 130 Mulford Hall, Berkeley, CA 94720 USA. EM crlevine@berkeley.edu; rdyanai@syr.edu; ggl@nyserda.ny.gov; daburns@usgs.gov; ctdrisco@syr.edu; glawrenc@usgs.gov; lynch.jason@epamail.epa.gov; nina.schoch@briloon.org RI Driscoll, Charles/F-9832-2014; OI Driscoll, Charles/0000-0003-2692-2890 FU New York State Energy Research and Development Authority; Adirondack Lakes Survey Corporation; National Science Foundation FX Support for this study was provided by the New York State Energy Research and Development Authority. We appreciate the support of the Adirondack Lakes Survey Corporation and the New York State Department of Environmental Conservation in providing lake chemistry data from the Adirondack Long Term Monitoring program. We thank Kevin Civerolo, Alan Domaracki, and Gary Lovett for providing valuable feedback on an earlier version of this work and Eddie Bevilacqua for advising us on mixed model analyses. Thanks also to the Journal of Forestry for permission to reprint the map of Hubbard Brook W6. The Hubbard Brook Experimental Forest is operated and maintained by the USDA Forest Service, Northern Research Station, Newtown Square, PA. Hubbard Brook is part of the Long-Term Ecological Research (LTER) network, which is supported by the National Science Foundation. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 36 TC 13 Z9 13 U1 1 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD APR PY 2014 VL 39 BP 94 EP 101 DI 10.1016/j.ecolind.2013.12.010 PG 8 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AB3IX UT WOS:000331685600011 ER PT J AU Kelly, JT Baker, KR Nowak, JB Murphy, JG Markovic, MZ VandenBoer, TC Ellis, RA Neuman, JA Weber, RJ Roberts, JM Veres, PR de Gouw, JA Beaver, MR Newman, S Misenis, C AF Kelly, James T. Baker, Kirk R. Nowak, John B. Murphy, Jennifer G. Markovic, Milos Z. VandenBoer, Trevor C. Ellis, Raluca A. Neuman, J. Andrew Weber, Rodney J. Roberts, James M. Veres, Patrick R. de Gouw, Joost A. Beaver, Melinda R. Newman, Sally Misenis, Chris TI Fine-scale simulation of ammonium and nitrate over the South Coast Air Basin and San Joaquin Valley of California during CalNex-2010 SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID IONIZATION MASS-SPECTROMETRY; LOS-ANGELES BASIN; UNITED-STATES; ATMOSPHERIC AMMONIA; BOUNDARY-LAYER; PARTICLE-SIZE; MODEL; AEROSOL; QUALITY; SURFACE AB National ambient air quality standards (NAAQS) have been set for PM2.5 due to its association with adverse health effects. PM2.5 design values in the South Coast Air Basin (SoCAB) and San Joaquin Valley of California exceed NAAQS levels, and NH4+ and NO3- make up the largest fraction of total PM2.5 mass on polluted days. Here we evaluate fine-scale simulations of PM2.5 NH4+ and NO3- with the Community Multiscale Air Quality model using measurements from routine networks and the California Research at the Nexus of Air Quality and Climate Change 2010 campaign. The model correctly simulates broad spatial patterns of NH4+ and NO3- including the elevated concentrations in eastern SoCAB. However, areas for model improvement have been identified. NH3 emissions from livestock and dairy facilities appear to be too low, while those related to waste disposal in western SoCAB may be too high. Analyses using measurements from flights over SoCAB suggest that problems with NH3 predictions can influence NO3- predictions there. Offline ISORROPIA II calculations suggest that overpredictions of NHx in Pasadena cause excessive partitioning of total nitrate to the particle phase overnight, while underpredictions of Na+ cause too much partitioning to the gas phase during the day. Also, the model seems to underestimate mixing during the evening boundary layer transition leading to excessive nitrate formation on some nights. Overall, the analyses demonstrate fine-scale variations in model performance within and across the air basins. Improvements in inventories and spatial allocations of NH3 emissions and in parameterizations of sea spray emissions, evening mixing processes, and heterogeneous ClNO2 chemistry could improve model performance. C1 [Kelly, James T.; Baker, Kirk R.; Misenis, Chris] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Nowak, John B.; Neuman, J. Andrew; Veres, Patrick R.; de Gouw, Joost A.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Nowak, John B.; Neuman, J. Andrew; Roberts, James M.; Veres, Patrick R.; de Gouw, Joost A.] NOAA, Div Chem Sci, Earth Syst Res Lab, Boulder, CO USA. [Murphy, Jennifer G.; Markovic, Milos Z.; VandenBoer, Trevor C.; Ellis, Raluca A.] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada. [Weber, Rodney J.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Beaver, Melinda R.] CALTECH, Pasadena, CA 91125 USA. [Newman, Sally] CALTECH, Div Geol & Planetary Sci, Pasadena, CA 91125 USA. RP Kelly, JT (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. EM kelly.james@epa.gov RI Neuman, Andy/A-1393-2009; Murphy, Jennifer/C-2367-2011; Nowak, John/B-1085-2008; Kelly, James/F-8135-2010; Roberts, James/A-1082-2009; de Gouw, Joost/A-9675-2008; VandenBoer, Trevor/F-1032-2011; Manager, CSD Publications/B-2789-2015; Veres, Patrick/E-7441-2010 OI Neuman, Andy/0000-0002-3986-1727; Nowak, John/0000-0002-5697-9807; Kelly, James/0000-0001-6574-5714; Roberts, James/0000-0002-8485-8172; de Gouw, Joost/0000-0002-0385-1826; VandenBoer, Trevor/0000-0001-8926-4237; Veres, Patrick/0000-0001-7539-353X NR 57 TC 20 Z9 20 U1 3 U2 33 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 27 PY 2014 VL 119 IS 6 BP 3600 EP 3614 DI 10.1002/2013JD021290 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AH3SV UT WOS:000336046600052 ER PT J AU Donohue, MJ O'Connell, K Vesper, SJ Mistry, JH King, D Kostich, M Pfaller, S AF Donohue, Maura J. O'Connell, Katharine Vesper, Stephen J. Mistry, Jatin H. King, Dawn Kostich, Mitch Pfaller, Stacy TI Widespread Molecular Detection of Legionella pneumophila Serogroup 1 in Cold Water Taps across the United States SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; ACQUIRED LEGIONNAIRES-DISEASE; CHEMICALLY DEFINED MEDIUM; TIME PCR ASSAY; DRINKING-WATER; CONVENTIONAL CULTURE; SAMPLES; MONOCHLORAMINE; SPP.; COLONIZATION AB In the United States, 6,868 cases of legionellosis were reported to the Center for Disease Control and Prevention in 2009-2010. Of these reports, it is estimated that 84% are caused by the microorganism Legionella pneumophila Serogroup (Sg) 1. Legionella spp. have been isolated and recovered from a variety of natural freshwater environments. Human exposure to L. pneumophila Sg1 may occur from aerosolization and subsequent inhalation of household and facility water. In this study, two primer/probe sets (one able to detect L. pneumophila and the other L. pneumophila Sg1) were determined to be highly sensitive and selective for their respective targets. Over 272 water samples, collected in 2009 and 2010 from 68 public and private water taps across the United States, were analyzed using the two qPCR assays to evaluate the incidence of L. pneumophila Sg1. Nearly half of the taps showed the presence of L. pneumophila Sg1 in one sampling event, and 16% of taps were positive in more than one sampling event. This study is the first United States survey to document the occurrence and colonization of L. pneumophila Sg1 in cold water delivered from point of use taps. C1 [Donohue, Maura J.; Vesper, Stephen J.; King, Dawn; Kostich, Mitch; Pfaller, Stacy] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [O'Connell, Katharine] US EPA, ORISE, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Mistry, Jatin H.] US EPA, Drinking Water Sect, Dallas, TX 75202 USA. RP Donohue, MJ (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 West Martin Luther King Dr,Mail Stop 593, Cincinnati, OH 45268 USA. EM Donohue.maura@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX We sincerely thank all those who participated in this study. The authors would also wish to acknowledge Dr. Helen Buse and Jill Hoelle for sharing their Legionella culture collection with us. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency's administrative review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 53 TC 14 Z9 14 U1 3 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 18 PY 2014 VL 48 IS 6 BP 3145 EP 3152 DI 10.1021/es4055115 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AE2AP UT WOS:000333776000009 PM 24548208 ER PT J AU Koralegedara, NH Al-Abed, S Dionysiou, DD AF Koralegedara, Nadeesha H. Al-Abed, Souhail Dionysiou, Dionysios D. TI Leachability of metals from FGD gypsum used in agricultural purpose SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Koralegedara, Nadeesha H.; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Environm Engn, Cincinnati, OH 45221 USA. [Al-Abed, Souhail] US EPA, Cincinnati, OH 45224 USA. EM koralenh@mail.uc.edu NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 20-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600243 ER PT J AU Lemieux, PA AF Lemieux, P. A. TI Use of modeling to evaluate incineration of building decontamination waste from homeland security incidents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Lemieux, P. A.] US EPA, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. EM Lemieux.Paul@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 204-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600413 ER PT J AU Milians, K AF Milians, Karen TI Karen Milians: Environmental Protection Agency SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Milians, Karen] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. EM milianskaren@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 3-PROF PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457605231 ER PT J AU Williamson, TC AF Williamson, Tracy C. TI Chemistry positions at the US Environmental Protection Agency SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Williamson, Tracy C.] US EPA, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. EM tcwtcw33@aol.com NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 9-YCC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457605308 ER PT J AU Zhang, GS Zhang, YC Nadagouda, MN Han, CS O'Shea, K El-Sheikh, SM Ismail, AA Dionysiou, DD AF Zhang, Geshan Zhang, Yong Cai Nadagouda, Mallikarjuna N. Han, Changseok O'Shea, Kevin El-Sheikh, Said M. Ismail, Adel A. Dionysiou, Dionysios D. TI Visible light-activated S, N and C co-doped polymorphic TiO2 for the treatment of microcystin-LR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Zhang, Geshan; Han, Changseok; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45220 USA. [Zhang, Yong Cai] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China. [Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [O'Shea, Kevin] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [El-Sheikh, Said M.; Ismail, Adel A.] Cent Met R&D Inst, Cairo, Egypt. EM dionysios.d.dionysiou@uc.edu RI El-Sheikh, Said/S-5877-2016 OI El-Sheikh, Said/0000-0002-2570-8326 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 217-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600424 ER PT J AU Varma, RS AF Varma, Rajender S. TI Magnetically retrievable nano-catalysts in benign media SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc ID ASSISTED ORGANIC-SYNTHESIS; MICROWAVE; NANOPARTICLES C1 [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM Varma.Rajender@epa.gov NR 13 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 689-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455204426 ER PT J AU Varma, RS AF Varma, Rajender S. TI Greener pathways for the synthesis of nanomaterials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM Varma.Rajender@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 55-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455203722 ER PT J AU Olaguer, EP Kolb, CE Lefer, B Rappenglueck, B Zhang, RY Pinto, JP AF Olaguer, Eduardo P. Kolb, Charles E. Lefer, Barry Rappenglueck, Bernhard Zhang, Renyi Pinto, Joseph P. TI Overview of the SHARP campaign: Motivation, design, and major outcomes SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article DE radical precursors; formaldehyde; nitrous acid; air quality; field study; measurements ID TEXAS AIR-QUALITY; NITROUS-ACID HONO; DIFFERENTIAL OPTICAL-ABSORPTION; IONIZATION MASS-SPECTROMETRY; INDUSTRIAL EMISSIONS; STATISTICAL-ANALYSIS; URBAN ATMOSPHERE; ANNULAR DENUDER; TRANSPORT MODEL; SULFURIC-ACID AB The Study of Houston Atmospheric Radical Precursors (SHARP) was a field campaign developed by the Houston Advanced Research Center on behalf of the Texas Environmental Research Consortium. SHARP capitalized on previous research associated with the Second Texas Air Quality Study and the development of the State Implementation Plan (SIP) for the Houston-Galveston-Brazoria (HGB) ozone nonattainment area. These earlier studies pointed to an apparent deficit in ozone production in the SIP attainment demonstration model despite the enhancement of simulated emissions of highly reactive volatile organic compounds in accordance with the findings of the original Texas Air Quality Study in 2000. The scientific hypothesis underlying the SHARP campaign was that there are significant undercounted primary and secondary sources of the radical precursors, formaldehyde, and nitrous acid, in both heavily industrialized and more typical urban areas of Houston. These sources, if properly taken into account, could increase the production of ozone in the SIP model and the simulated efficacy of control strategies designed to bring the HGB area into ozone attainment. This overview summarizes the precursor studies and motivations behind SHARP, as well as the overall experimental design and major findings of the 2009 field campaign. These findings include significant combustion sources of formaldehyde at levels greater than accounted for in current point source emission inventories; the underestimation of formaldehyde and nitrous acid emissions, as well as CO/NOx and NO2/NOx ratios, by mobile source models; and the enhancement of nitrous acid by atmospheric organic aerosol. Key Points Primary and secondary sources of HCHO and HONO are underestimated in the Houston airshed C1 [Olaguer, Eduardo P.] Houston Adv Res Ctr, The Woodlands, TX 77381 USA. [Kolb, Charles E.] Aerodyne Res Inc, Billerica, MA USA. [Lefer, Barry; Rappenglueck, Bernhard] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX USA. [Zhang, Renyi] Texas A&M Univ, Ctr Atmospher Chem & Environm, College Stn, TX USA. [Pinto, Joseph P.] US EPA, Res Triangle Pk, NC 27711 USA. RP Olaguer, EP (reprint author), Houston Adv Res Ctr, The Woodlands, TX 77381 USA. EM eolaguer@harc.edu RI Kolb, Charles/A-8596-2009; Zhang, Renyi/A-2942-2011; OI Lefer, Barry/0000-0001-9520-5495 FU State of Texas under the Texas Emissions Reduction Plan through the Texas Environmental Research Consortium FX We would like to acknowledge the various participants in the SHARP campaign whose work is cited in this overview, including Jochen Stutz of UCLA, Johan Mellqvist of Chalmers University of Technology, Sweden, Don Collins of Texas A&M University, Xinrong Ren of the University of Miami, William Brune of Pennsylvania State University, and several other colleagues who helped make SHARP a success. Funding for SHARP was provided by the State of Texas under the Texas Emissions Reduction Plan through the Texas Environmental Research Consortium. The information in this document has been subjected to review by the National Center for Environmental Assessment, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 77 TC 11 Z9 11 U1 4 U2 26 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 16 PY 2014 VL 119 IS 5 BP 2597 EP 2610 DI 10.1002/2013JD019730 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AE3OL UT WOS:000333885700036 ER PT J AU Yang, GX Best, EPH Whiteaker, T Teklitz, A Yeghiazarian, L AF Yang, Guoxiang Best, Elly P. H. Whiteaker, Tim Teklitz, Allen Yeghiazarian, Lilit TI A screening-level modeling approach to estimate nitrogen loading and standard exceedance risk, with application to the Tippecanoe River watershed, Indiana SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Nitrogen; Loading; TMDL; Spatial scales; Risk assessment; Screening-level model ID LAND-USE; BAYESIAN-APPROACH; QUALITY; UNCERTAINTY; PHOSPHORUS; MANAGEMENT; IMPACT; LAKES; BAY AB This paper presents a screening-level modeling approach that can be used to rapidly estimate nutrient loading, assess numerical nutrient standard exceedance risk of surface waters leading to potential classification as impaired for designated use, and explore best management practice (BMP) implementation to reduce loading with a relatively low data requirement. The modeling framework uses a hybrid statistical and process based approach to estimate source of pollutants, their transport and decay in the terrestrial and aquatic parts of watersheds. The framework is developed in the ArcGIS environment and is based on the total maximum daily load (TMDL) balance model. Nitrogen (N) is currently addressed in the framework, referred to as WQM-TMDL-N. Loading for each catchment includes non-point sources (NPS) and point sources (PS). The probability of a nutrient load to exceed a target load is evaluated using probabilistic risk assessment, by including the uncertainty associated with export coefficients of various land uses. In an application of this modeling approach to the Tippecanoe River watershed in Indiana, USA, total nitrogen (TN) loading, confidence interval and risk of standard exceedance leading to potential impairment were estimated. Model results suggest that decay coefficients decrease, and delivery fractions increase with increasing stream order. The spatial distribution pattern of delivered incremental TN yield shows a trend similar to that of the delivery fraction in this watershed. The target TN exceedance risk increases considerably when switching from Indiana draft-N benchmark to far lower EPA-proposed TN criteria, suggesting that load reduction to meet the latter criteria may benefit from BMP implementation through source control and delivery reduction. (c) 2014 Elsevier Ltd. All rights reserved. C1 [Yang, Guoxiang] US EPA, Natl Risk Management Res Lab, ORISE, Cincinnati, OH 45268 USA. [Best, Elly P. H.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Whiteaker, Tim] Univ Texas Austin, Ctr Res Water Resources, Austin, TX 78712 USA. [Teklitz, Allen; Yeghiazarian, Lilit] Univ Cincinnati, SEEBME, Cincinnati, OH 45221 USA. RP Best, EPH (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM yang.gavin@epa.gov; best.elly@epa.gov; twhit@mail.utexas.edu; teklitag@mail.uc.edu; yeghialt@ucmail.uc.edu RI Yang, Guoxiang/I-5619-2012 FU EPA/ORD Safe and Sustainable Water Research Program FX This research was supported by the EPA/ORD Safe and Sustainable Water Research Program. The help in identifying and retrieving critical water quality data for this study provided by S. Sobat and J. Wood, IDEM Office of Water Quality, is gratefully acknowledged. NR 43 TC 5 Z9 7 U1 2 U2 36 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD MAR 15 PY 2014 VL 135 BP 1 EP 10 DI 10.1016/j.jenvman.2014.01.003 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA AF1MD UT WOS:000334477100001 PM 24486566 ER PT J AU Cheng, WY Larson, JM Samet, JM AF Cheng, Wan-Yun Larson, Jeffrey M. Samet, James M. TI Monitoring intracellular oxidative events using dynamic spectral unmixing microscopy SO METHODS LA English DT Article DE Spectral unmixing microscopy; Oxidative stress; Live cell imaging ID GREEN FLUORESCENT PROTEIN; INDICATORS; CELLS AB There is increasing interest in using live cell imaging to monitor not just individual intracellular end-points, but to investigate the interplay between multiple molecular events as they unfold in real time within the cell. A major impediment to simultaneous acquisition of fluorescent signals from multiple probes is that emission spectra of many fluorophores overlap, often with maxima that are only a few nanometers apart. Spectral acquisition of mixed fluorescence signals captured within a dedicated scanning range can be used to quantitatively separate signals into component spectra. We report here the development of a novel live cell application of spectral unmixing for the simultaneous monitoring of intracellular events reported by closely-emitting fluorophores responding dynamically to external stimuli. We validate the performance of dynamic spectral unmixing microscopy (DynSUM) using genetically encoded sensors to simultaneously monitor changes in glutathione redox potential (Egsh) and H2O2 production in living cells exposed to oxidizing and reducing agents. We further demonstrate the utility of the DynSUM approach to observe the relationship between the increases in Egsh and H2O2 generation induced in airway epithelial cells exposed to an environmental electrophile. Published by Elsevier Inc. C1 [Cheng, Wan-Yun] Univ N Carolina, Chapel Hill, NC USA. [Larson, Jeffrey M.] Nikon Instruments Inc, Confocal Syst, Melville, NY USA. [Samet, James M.] US EPA, Environm Publ Hlth Div, NHEERL, Chapel Hill, NC 27599 USA. RP Samet, JM (reprint author), US EPA, Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM Samet.James@EPA.gov NR 10 TC 4 Z9 4 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-2023 EI 1095-9130 J9 METHODS JI Methods PD MAR 15 PY 2014 VL 66 IS 2 BP 345 EP 352 DI 10.1016/j.ymeth.2013.06.008 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AE1ZM UT WOS:000333773100025 PM 23816786 ER PT J AU Mishra, DR Schaeffer, BA Keith, D AF Mishra, Deepak R. Schaeffer, Blake A. Keith, Darryl TI Performance evaluation of normalized difference chlorophyll index in northern Gulf of Mexico estuaries using the Hyperspectral Imager for the Coastal Ocean SO GISCIENCE & REMOTE SENSING LA English DT Article DE HyperSAS; HICO; chlorophyll-a; remote sensing reflectance; NDCI ID REMOTE-SENSING REFLECTANCE; TURBID PRODUCTIVE WATERS; A CONCENTRATION; SEMIANALYTICAL MODEL; SATELLITE DATA; QUALITY; SCATTERING; BAY; RED; ALGORITHMS AB The Hyperspectral Imager for the Coastal Ocean (HICO) was used to derive chlorophyll-a (chl-a) based on the normalized difference chlorophyll index (NDCI) in two Gulf of Mexico coastal estuaries. Chl-a data were acquired from discrete in situ water sample analysis and above-water hyperspectral surface acquisition system (HyperSAS) remote sensing reflectance in Pensacola Bay (PB) and Choctawhatchee Bay (CB). NDCI algorithm calibrations and validations were completed on HICO data. Linear and best-fit (polynomial) calibrations performed strongly with R-2 of 0.90 and 0.96, respectively. The best validation of NDCI resulted with an R-2 of 0.74 and root-mean-square error (RMSE) of 1.64 mu g/L. A strong spatial correspondence was observed between NDCI and chl-a, with higher NDCI associated with higher chl-a and these areas were primarily located in the northern PB and eastern CB at the river mouths. NDCI could be effectively used as a qualitative chl-a monitoring tool with a reduced need for site-specific calibration. C1 [Mishra, Deepak R.] Univ Georgia, Dept Geog, Athens, GA 30602 USA. [Schaeffer, Blake A.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Durham, NC 27711 USA. [Keith, Darryl] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA. RP Mishra, DR (reprint author), Univ Georgia, Dept Geog, Athens, GA 30602 USA. EM dmishra@uga.edu FU US Environmental Protection Agency Office of Research and Development; EPA Pathfinder Innovation Project FX The information in this document has been funded in part by the US Environmental Protection Agency Office of Research and Development and an EPA Pathfinder Innovation Project. NR 47 TC 7 Z9 7 U1 2 U2 13 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1548-1603 EI 1943-7226 J9 GISCI REMOTE SENS JI GISci. Remote Sens. PD MAR 4 PY 2014 VL 51 IS 2 SI SI BP 175 EP 198 DI 10.1080/15481603.2014.895581 PG 24 WC Geography, Physical; Remote Sensing SC Physical Geography; Remote Sensing GA AE3IM UT WOS:000333870200005 ER PT J AU Rose, JM Bricker, SB Tedesco, MA Wikfors, GH AF Rose, Julie M. Bricker, Suzanne B. Tedesco, Mark A. Wikfors, Gary H. TI A Role for Shellfish Aquaculture in Coastal Nitrogen Management SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ECOLOGICAL CARRYING-CAPACITY; CHESAPEAKE BAY; CONTROLLING EUTROPHICATION; ORGANIC NITROGEN; PHYTOPLANKTON; ESTUARIES; BIOAVAILABILITY; RESTORATION; ENVIRONMENT; PHOSPHORUS AB Excess nutrients in the coastal environment have been linked to a host of environmental problems, and nitrogen reduction efforts have been a top priority of resource managers for decades. The use of shellfish for coastal nitrogen remediation has been proposed, but formal incorporation into nitrogen management programs is lagging. Including shellfish aquaculture in existing nitrogen management programs makes sense from environmental, economic, and social perspectives, but challenges must be overcome for large-scale implementation to be possible. C1 [Rose, Julie M.; Wikfors, Gary H.] NOAA Fisheries, Northeast Fisheries Sci Ctr, Milford Lab, Milford, CT 06460 USA. [Bricker, Suzanne B.] NOAA NCCOS, Silver Spring, MD 20910 USA. [Tedesco, Mark A.] US EPA, Long Isl Sound Off, Stamford, CT 06901 USA. RP Rose, JM (reprint author), NOAA Fisheries, Northeast Fisheries Sci Ctr, Milford Lab, 212 Rogers Ave, Milford, CT 06460 USA. EM julie.rose@noaa.gov FU NOAA Fisheries Office of Aquaculture FX We acknowledge NOAA Fisheries Office of Aquaculture for their support. NR 64 TC 14 Z9 14 U1 0 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 4 PY 2014 VL 48 IS 5 BP 2519 EP 2525 DI 10.1021/es4041336 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AC4MA UT WOS:000332494200002 PM 24506309 ER PT J AU Jain, P Powell, JT Smith, JL Townsend, TG Tolaymat, T AF Jain, Pradeep Powell, Jon T. Smith, Justin L. Townsend, Timothy G. Tolaymat, Thabet TI Life-Cycle Inventory and Impact Evaluation of Mining Municipal Solid Waste Landfills SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article AB Recent research and policy directives have emerged with a focus on sustainable management of waste materials, and the mining of old landfills represents an opportunity to meet sustainability goals by reducing the release of liquid- and gas-phase contaminants into the environment, recovering land for more productive use, and recovering energy from the landfilled materials. The emissions associated with the landfill mining process (waste excavation, screening, and on-site transportation) were inventoried on the basis of diesel fuel consumption data from two hill-scale mining projects (1.3-1.5 L/in-place m(3) of landfill space mined) and unit emissions (mass per liter of diesel consumption) from heavy equipment typically deployed for mining landfills. An analytical framework was developed and used in an assessment of the life-cycle environmental impacts of a few end-use management options for materials deposited and mined from an unlined landfill. The results showed that substantial greenhouse gas emission reductions can be realized in both the waste relocation and materials and energy recovery scenarios compared to a "do nothing" case. The recovery of metal components from landfilled waste was found to have the greatest benefit across nearly all impact categories evaluated, while emissions associated with heavy equipment to mine the waste itself were found to be negligible compared to the benefits that mining provided. C1 [Jain, Pradeep; Powell, Jon T.; Smith, Justin L.] Innovat Waste Consulting Serv LLC, Gainesville, FL 32605 USA. [Townsend, Timothy G.] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA. [Tolaymat, Thabet] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Tolaymat, T (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King St, Cincinnati, OH 45268 USA. EM tolaymat.thabet@epa.gov FU U.S. EPA's Office of Research and Development FX This research was funded by the U.S. EPA's Office of Research and Development. The manuscript has not been subjected to the Agency's internal review; therefore, the opinions expressed in this paper are those of the author(s) and do not, necessarily, reflect the official positions and policies of the U.S. EPA. Any mention of products or trade names does not constitute recommendation for use by the U.S. EPA. The authors acknowledge the contributions of Ali Bigger, Lizmarie Maldonado, and Saraya Pleasant. The authors acknowledge assistance of Mark Allen of Cooper, Barnette, and Page, Inc. for providing fossil fuel consumption data for the Perdido Landfill Mining Project. NR 24 TC 6 Z9 6 U1 1 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 4 PY 2014 VL 48 IS 5 BP 2920 EP 2927 DI 10.1021/es404382s PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AC4MA UT WOS:000332494200048 PM 24512420 ER PT J AU Kimbrough, S Palma, T Baldauf, RW AF Kimbrough, Sue Palma, Ted Baldauf, Richard W. TI Analysis of mobile source air toxics (MSATs)-Near-road VOC and carbonyl concentrations SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID LAS-VEGAS; QUALITY; ACETALDEHYDE; FORMALDEHYDE; VARIABILITY; POLLUTANTS; RISKS; NO2 AB Exposures to mobile source air toxics (MSATs) have been associated with numerous adverse health effects. While thousands of air toxic compounds are emitted from mobile sources, members of a subset of compounds are considered high priority due to their significant contribution to cancer and noncancer health risks and the contribution of mobile sources to total exposure as evaluated by the U.S. Environmental Protection Agency (EPA) National-Scale Air Toxics Assessments (NATA). These pollutants include benzene, 1,3-butadiene, ethylbenzene, acrolein, acetaldehyde, formaldehyde, naphthalene, polycyclic organic matter, and diesel particulate matter/organic gases. This study provided year-long trends of benzene, 1,3-butadiene, acrolein, acetaldehyde, and formaldehyde in Las Vegas, NV. Results indicated that MSAT concentrations often did not exhibit trends typical of other primary emitted pollutants in this study. Instead, other mobile sources beyond the highway of interest contributed to the measured values, including a major arterial road, a large commercial airport, and a nearby parking lot. The data were compared with relevant census-tract NATA estimates, with estimated ambient 1,3-butadiene concentrations similar to the measured values. Measured benzene values were much lower relative to the NATA total ambient benzene concentrations. Measured acrolein values were much higher relative to the NATA total acrolein concentrations. Measured acetaldehyde and formaldehyde values were also higher relative to the NATA total acetaldehyde and formaldehyde concentrations for all wind conditions and downwind conditions. Some possible explanations for these differences include nearby sources influencing the measured values; meteorological influences that may not be well captured by the NATA modeling regime; chemical reactivity of measured compounds; and additional explanatory variables may be needed for certain urban areas in order to accurately disaggregate anthropogenic air toxics emissions. Implications: Comparison of air toxics concentrations measured at four long-term near-road sites in Las Vegas, NV, show generally good agreement with the EPA 2005 NATA total ambient concentrations. Measured concentrations did not compare as well with EPA 2005 NATA for the on-road mobile portion of the ambient concentrations. This highlights the complexity of air toxic emission sources and impacts in urban areas, especially around large highway facilities; NATA's inability to capture local-scale meteorology and fine-scale ambient gradients; and that additional explanatory variables may be needed for certain urban areas in order to accurately disaggregate anthropogenic air toxics emissions. = 3.0 kg N ha(-1) yr(-1) as dry NH3 deposition. Depending on the definition of the background air concentration, annual nitrogen loading to the refuge from background NH3 dry deposition and NH3 dry deposition associated with elevated concentrations downwind of the facility is between 41% and 79% higher than background dry NH3 deposition alone. Relative to the total N deposition budget for the refuge, which includes all nitrogen compounds, total background N deposition plus NH3 dry deposition associated with elevated concentrations downwind of the facility is, correspondingly, 6-10% greater than background total N deposition alone. From a process standpoint, predicted fluxes are most sensitive to uncertainty in the parameterization of the cuticular resistance. Published by Elsevier B.V. C1 [Walker, John T.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Robarge, Wayne P.; Austin, Robert] N Carolina State Univ, Dept Soil Sci, Raleigh, NC 27695 USA. RP Walker, JT (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM walker.johnt@epa.gov RI Walker, John/I-8880-2014 OI Walker, John/0000-0001-6034-7514 FU U.S. Fish and Wildlife Service [1434-HQ-97-RU-01568] FX We appreciate the field support of Aleksandra Njegovan (North Carolina State University) and Mark Barnes (North Carolina State University) and the laboratory support of Guillermo Ramirez (North Carolina State University). We appreciate the helpful comments and suggestions of Sara Ward (U.S. Fish and Wildlife Service) on earlier versions of this work. This work was funded by the U.S. Fish and Wildlife Service, Cooperative Agreement No. 1434-HQ-97-RU-01568. This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 33 TC 2 Z9 3 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8809 EI 1873-2305 J9 AGR ECOSYST ENVIRON JI Agric. Ecosyst. Environ. PD MAR 1 PY 2014 VL 185 BP 161 EP 175 DI 10.1016/j.agee.2013.10.029 PG 15 WC Agriculture, Multidisciplinary; Ecology; Environmental Sciences SC Agriculture; Environmental Sciences & Ecology GA AF8PL UT WOS:000334978000018 ER PT J AU Yadav, JSS Bezawada, J Yan, S Tyagi, RD Surampalli, RY AF Yadav, Jay Shankar Singh Bezawada, Jyothi Yan, Song Tyagi, R. D. Surampalli, R. Y. TI Permeabilization of Kluyveromyces marxianus with Mild Detergent for Whey Lactose Hydrolysis and Augmentation of Mixed Culture SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article DE beta-galactosidase; Kluyveromyces marxianus; N-lauroyl sarcosine; Permeabilization; Lactose hydrolysis; Mixed culture; Single-cell protein ID YEAST-CELLS; BETA-GALACTOSIDASE; BAKERS-YEAST; CHEESE WHEY; FRAGILIS; CATALASE AB Cheese whey is a by-product of cheese-manufacturing industries, and the utilization of whey is a challenging problem either to use it or dispose it, because only few microorganisms can metabolize the whey lactose. Enzymatic hydrolysis of whey lactose to glucose and galactose by beta-galactosidase is the approach for biotechnological application. Kluyveromyces marxianus cells were permeabilized with non-toxic, biodegradable, anionic detergent N-lauroyl sarcosine (N-LS) for the enzyme activity. The permeabilization process parameters (N-LS concentration, solvent volume, temperature and incubation time) were optimized. The maximum beta-galactosidase activity of 1,220 IU/g dry weight was obtained using permeabilized cells under optimized conditions. Moreover, viability of the permeabilized cells was also evaluated, which showed that cells were alive; however, viability was reduced by two log cycles. The permeabilized cells were evaluated for whey lactose hydrolysis. The maximum lactose hydrolysis of 91 % was observed with 600 mg (dry cell weight/100 mL) in whey powder (5 % w/v) solution at 180-min incubation, pH 6.5 and 30 degrees C. Further, the hydrolyzed whey was evaluated for amelioration of growth of non-lactose-consuming yeast Saccharomyces cerevisiae. S. cerevisiae was able to grow in hydrolyzed whey simultaneously with K. marxianus. The study confirmed that N-LS could be used to permeabilize K. marxianus cells to make available the enzyme activity. C1 [Yadav, Jay Shankar Singh; Bezawada, Jyothi; Yan, Song; Tyagi, R. D.] Univ Quebec, Ctr Eau Terre & Environm, Inst Natl Rech Sci, Quebec City, PQ G1K 9A9, Canada. [Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA. RP Tyagi, RD (reprint author), Univ Quebec, Ctr Eau Terre & Environm, Inst Natl Rech Sci, 490 Couronne, Quebec City, PQ G1K 9A9, Canada. EM tyagi@ete.inrs.ca FU Natural Sciences and Engineering Research Council of Canada [A4984, RDCPJ379601-08]; Canada Research Chair FX The authors are sincerely thankful to the Natural Sciences and Engineering Research Council of Canada (Grant A4984, RDCPJ379601-08 and Canada Research Chair) for their financial support. NR 39 TC 3 Z9 3 U1 0 U2 9 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0273-2289 EI 1559-0291 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD MAR PY 2014 VL 172 IS 6 BP 3207 EP 3222 DI 10.1007/s12010-014-0755-z PG 16 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA AF0VM UT WOS:000334432400033 PM 24500798 ER PT J AU Garmo, OA Skjelkvale, BL de Wit, HA Colombo, L Curtis, C Folster, J Hoffmann, A Hruska, J Hogasen, T Jeffries, DS Keller, WB Kram, P Majer, V Monteith, DT Paterson, AM Rogora, M Rzychon, D Steingruber, S Stoddard, JL Vuorenmaa, J Worsztynowicz, A AF Garmo, Oyvind A. Skjelkvale, Brit Lisa de Wit, Heleen A. Colombo, Luca Curtis, Chris Folster, Jens Hoffmann, Andreas Hruska, Jakub Hogasen, Tore Jeffries, Dean S. Keller, W. Bill Kram, Pavel Majer, Vladimir Monteith, Don T. Paterson, Andrew M. Rogora, Michela Rzychon, Dorota Steingruber, Sandra Stoddard, John L. Vuorenmaa, Jussi Worsztynowicz, Adam TI Trends in Surface Water Chemistry in Acidified Areas in Europe and North America from 1990 to 2008 SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Acid deposition; Surfacewaters; Trend analysis; Monitoring network; Chemical recovery ID LONG-TERM TRENDS; ATMOSPHERIC NITROGEN DEPOSITION; NEW-YORK; INTERNATIONAL PROGRAM; ADIRONDACK REGION; CHEMICAL RECOVERY; UNITED-STATES; FRESH-WATERS; ICP-WATERS; ACIDIFICATION AB Acidification of lakes and rivers is still an environmental concern despite reduced emissions of acidifying compounds. We analysed trends in surface water chemistry of 173 acid-sensitive sites from 12 regions in Europe and North America. In 11 of 12 regions, non-marine sulphate (SO4*) declined significantly between 1990 and 2008 (-15 to -59 %). In contrast, regional and temporal trends in nitrate were smaller and less uniform. In 11 of 12 regions, chemical recovery was demonstrated in the form of positive trends in pH and/or alkalinity and/or acid neutralising capacity (ANC). The positive trends in these indicators of chemical recovery were regionally and temporally less distinct than the decline in SO4* and tended to flatten after 1999. From an ecological perspective, the chemical quality of surface waters in acid-sensitive areas in these regions has clearly improved as a consequence of emission abatement strategies, paving the way for some biological recovery. C1 [Garmo, Oyvind A.] Norwegian Inst Water Res NIVA, N-2312 Ottestad, Norway. [Skjelkvale, Brit Lisa; de Wit, Heleen A.; Hogasen, Tore] Norwegian Inst Water Res NIVA, Oslo, Norway. [Colombo, Luca] Univ Appl Sci Southern Switzerland, Canobbio, Switzerland. [Curtis, Chris] Univ Witwatersrand, GAES, Johannesburg, South Africa. [Folster, Jens] Swedish Univ Agr Sci, Uppsala, Sweden. [Hoffmann, Andreas] Umweltbundesamt, Dessau, Germany. [Hruska, Jakub; Kram, Pavel; Majer, Vladimir] Czech Geol Survey, Prague, Czech Republic. [Hruska, Jakub] Acad Sci Czech Republic, Global Change Res Ctr, Brno, Czech Republic. [Jeffries, Dean S.] Environm Canada, Burlington, ON L7R 4A6, Canada. [Keller, W. Bill] Laurentian Univ, Sudbury, ON P3E 2C6, Canada. [Monteith, Don T.] Lancaster Environm Ctr, NERC Ctr Ecol & Hydrol, Lancaster, England. [Paterson, Andrew M.] Ontario Minist Environm, Dorset, ON, Canada. [Rogora, Michela] CNR Inst Ecosyst Study, Verbania, Italy. [Rzychon, Dorota; Worsztynowicz, Adam] Inst Ecol Ind Areas, Katowice, Poland. [Steingruber, Sandra] Ufficio Aria Clima & Energie Rinnovabili, Bellinzona, Switzerland. [Stoddard, John L.] US EPA, Corvallis, OR USA. [Vuorenmaa, Jussi] Finnish Environm Inst, Helsinki, Finland. RP Garmo, OA (reprint author), Norwegian Inst Water Res NIVA, Sandvikavegen 59, N-2312 Ottestad, Norway. EM oga@niva.no RI Hruska, Jakub/G-1562-2014; Monteith, Donald/C-1534-2008; Curtis, Christopher/A-1768-2013; Keller, Wendel/G-1533-2012; ROGORA, MICHELA/B-9237-2008; OI Monteith, Donald/0000-0003-3219-1772; Curtis, Christopher/0000-0002-6597-2172; ROGORA, MICHELA/0000-0003-3515-0220; Stoddard, John/0000-0002-2537-6130 FU Norwegian Environment Agency; Trust fund under UNECE FX We are grateful to all Focal centres that submit data to the ICP Waters programme centre, making large regional assessments of the environmental state of nutrient poor, acid-sensitive lakes, and rivers possible. We also thank the Norwegian Environment Agency and the Trust fund under UNECE for economic support. NR 54 TC 21 Z9 21 U1 13 U2 84 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 EI 1573-2932 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD MAR PY 2014 VL 225 IS 3 AR 1880 DI 10.1007/s11270-014-1880-6 PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA AF2YG UT WOS:000334577800007 ER PT J AU McCrackin, ML Harrison, JA Compton, JE AF McCrackin, Michelle L. Harrison, John A. Compton, Jana E. TI Factors influencing export of dissolved inorganic nitrogen by major rivers: A new, seasonal, spatially explicit, global model SO GLOBAL BIOGEOCHEMICAL CYCLES LA English DT Article DE nitrogen; river; water quality; fertilizer; model; coastal zone ID GULF-OF-MEXICO; UNITED-STATES; ANTHROPOGENIC NITROGEN; FUTURE PROJECTIONS; MARINE ECOSYSTEMS; MISSISSIPPI RIVER; LARGE WATERSHEDS; COASTAL ZONE; PHOSPHORUS; PATTERNS AB Substantial effort has focused on understanding spatial variation in dissolved inorganic nitrogen (DIN) export to the coastal zone and specific basins have been studied in depth. Much less is known, however, about seasonal patterns and controls of coastal DIN delivery across large spatial scales. Understanding seasonal patterns of DIN export is critical to efforts to predict impacts of coastal eutrophication, such as algal blooms and hypoxic areas, which are often seasonal phenomena. Here we describe, test, and apply a global model that predicts seasonal DIN export to coastal regions for >6000 rivers using the Nutrient Export from Watersheds (NEWS2) model. NEWS2-DIN-S used spatially explicit, seasonal N inputs and was calibrated with measured DIN yield (kgNkm(-2) season(-1)) for 77 rivers, distributed globally. Of the characteristics considered, DIN-transport efficiency was positively related to runoff and negatively related to temperature (r(2)=0.34-0.60, depending on season p<0.0001), likely due to flushing effects and increased retention by plants and soils, respectively. NEWS2-DIN-S incorporated these insights and performed well in predicting DIN yield (Nash-Sutcliffe Efficiency=0.54-0.65, depending on season). Catchments were effective in retaining DIN and average export rates were lower during the growing season (3-5% of total nitrogen inputs) compared to other seasons (6-10%) for major latitude bands. Model output was insensitive to changes in the magnitude of N inputs, suggesting that refinement of seasonal N input budgets will not substantially improve model performance. Rather, better representation of land-to-river N transfers could improve future models because of strong landscape N attenuation. Key Points Catchment DIN attenuation is greater in summer compared to other seasons Both runoff and temperature influence seasonal DIN-transport efficiency Depending on season and latitude, 3-10% of TN inputs are exported as DIN C1 [McCrackin, Michelle L.; Harrison, John A.] Washington State Univ, Sch Environm, Vancouver, WA 98686 USA. [McCrackin, Michelle L.] Natl Acad Sci, Natl Res Council, Washington, DC 20418 USA. [Compton, Jana E.] US EPA, Western Ecol Div, Corvallis, OR USA. RP McCrackin, ML (reprint author), Washington State Univ, Sch Environm, Vancouver, WA 98686 USA. EM michelle.mccrackin@vancouver.wsu.edu OI McCrackin, Michelle/0000-0002-8570-2831 FU National Academies of Science Research Associateship Program; U.S. Environmental Protection Agency; UNESCO-IOC FX We thank Ellen Cooter and two anonymous reviewers whose comments of greatly improved this paper. The information in this manuscript was funded by the National Academies of Science Research Associateship Program, the U.S. Environmental Protection Agency, and UNESCO-IOC. This paper has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 69 TC 5 Z9 5 U1 4 U2 42 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0886-6236 EI 1944-9224 J9 GLOBAL BIOGEOCHEM CY JI Glob. Biogeochem. Cycle PD MAR PY 2014 VL 28 IS 3 BP 269 EP 285 DI 10.1002/2013GB004723 PG 17 WC Environmental Sciences; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences GA AE8PY UT WOS:000334265000007 ER PT J AU Nash, KL Allen, CR Angeler, DG Barichievy, C Eason, T Garmestani, AS Graham, NAJ Granholm, D Knutson, M Nelson, RJ Nystrom, M Stow, CA Sundstrom, SM AF Nash, Kirsty L. Allen, Craig R. Angeler, David G. Barichievy, Chris Eason, Tarsha Garmestani, Ahjond S. Graham, Nicholas A. J. Granholm, Dean Knutson, Melinda Nelson, R. John Nystroem, Magnus Stow, Craig A. Sundstrom, Shana M. TI Discontinuities, cross-scale patterns, and the organization of ecosystems SO ECOLOGY LA English DT Article DE body mass; competition; discontinuity hypothesis; extinction; function; hierarchy theory; invasion; multiple-scale analysis; nonlinear responses; regime shift; resilience ID BODY-SIZE DISTRIBUTIONS; HIERARCHICAL PATCH DYNAMICS; EARLY-WARNING SIGNALS; RELATIVE RESILIENCE; MASS DISTRIBUTIONS; FUNCTIONAL-GROUPS; BIRD COMMUNITIES; COMPLEX-SYSTEMS; CORAL-REEFS; ECOLOGICAL RESILIENCE AB Ecological structures and processes occur at specific spatiotemporal scales, and interactions that occur across multiple scales mediate scale-specific (e.g., individual, community, local, or regional) responses to disturbance. Despite the importance of scale, explicitly incorporating a multi-scale perspective into research and management actions remains a challenge. The discontinuity hypothesis provides a fertile avenue for addressing this problem by linking measureable proxies to inherent scales of structure within ecosystems. Here we outline the conceptual framework underlying discontinuities and review the evidence supporting the discontinuity hypothesis in ecological systems. Next we explore the utility of this approach for understanding cross-scale patterns and the organization of ecosystems by describing recent advances for examining nonlinear responses to disturbance and phenomena such as extinctions, invasions, and resilience. To stimulate new research, we present methods for performing discontinuity analysis, detail outstanding knowledge gaps, and discuss potential approaches for addressing these gaps. C1 [Nash, Kirsty L.; Graham, Nicholas A. J.] James Cook Univ, ARC Ctr Excellence Coral Reef Studies, Townsville, Qld 4811, Australia. [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, SE-75007 Uppsala, Sweden. [Barichievy, Chris] Ithala Game Reserve, Ezemvelo KZN Wildlife, ZA-3150 Louwsberg, South Africa. [Barichievy, Chris] Univ Witwatersrand, Ctr African Ecol, ZA-2050 Johannesburg, South Africa. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Granholm, Dean] US Fish & Wildlife Serv, Bloomington, MN 55437 USA. [Knutson, Melinda] US Fish & Wildlife Serv, La Crosse, WI 54603 USA. [Nelson, R. John] Univ Victoria, Ctr Biomed Res, Victoria, BC V8P 5C2, Canada. [Nystroem, Magnus] Stockholm Univ, Stockholm Resilience Ctr, SE-10691 Stockholm, Sweden. [Stow, Craig A.] NOAA, Great Lakes Environm Res Lab, Ann Arbor, MI 48108 USA. [Sundstrom, Shana M.] Univ Nebraska, Sch Nat Resources, Lincoln, NE 68583 USA. RP Nash, KL (reprint author), James Cook Univ, ARC Ctr Excellence Coral Reef Studies, Townsville, Qld 4811, Australia. EM nashkirsty@gmail.com RI Graham, Nicholas/C-8360-2014; Nash, Kirsty/B-5456-2015; OI Nash, Kirsty/0000-0003-0976-3197; Sundstrom, Shana/0000-0003-0823-8008; Stow, Craig/0000-0001-6171-7855 FU United States Geological Survey's John Wesley Powell Center for Analysis and Synthesis; U.S. Geological Survey; Nebraska Game and Parks Commission; University of Nebraska; U.S. Fish and Wildlife Service; Wildlife Management Institute FX This work arose from discussions at the Managing for Resilience Working Group, funded by the United States Geological Survey's John Wesley Powell Center for Analysis and Synthesis. We thank two anonymous reviewers for their helpful comments. The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the U. S. Environmental Protection Agency or the U. S. Fish and Wildlife Service. The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement among the U.S. Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska, the U.S. Fish and Wildlife Service, and the Wildlife Management Institute. GLERL contribution number 1679. NR 124 TC 32 Z9 34 U1 5 U2 95 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0012-9658 EI 1939-9170 J9 ECOLOGY JI Ecology PD MAR PY 2014 VL 95 IS 3 BP 654 EP 667 DI 10.1890/13-1315.1 PG 14 WC Ecology SC Environmental Sciences & Ecology GA AC8ZH UT WOS:000332823100014 PM 24804450 ER PT J AU Roser, DJ Van den Akker, B Boase, S Haas, CN Ashbolt, NJ Rice, SA AF Roser, D. J. Van den Akker, B. Boase, S. Haas, C. N. Ashbolt, N. J. Rice, S. A. TI Pseudomonas aeruginosa dose response and bathing water infection SO EPIDEMIOLOGY AND INFECTION LA English DT Review DE folliculitis; dermatitis; Acute otitis externa ID VIRUS PARTICLE ADSORPTION; TOBACCO MOSAIC VIRUS; RISK-ASSESSMENT; SWIMMING POOLS; OTITIS-EXTERNA; MATHEMATICAL MODEL; ESCHERICHIA-COLI; DILUTION CURVE; BACTERIA; DERMATITIS AB Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Three model forms are identified for predicting disease likelihood from pathogen density. Two are based on Furumoto & Mickey's exponential 'single-hit' model and predict infection likelihood and severity (lesions/m(2)), respectively. 'Third-generation', mechanistic, dose-response algorithm development is additionally scoped. The proposed formulation integrates dispersion, epidermal interaction, and follicle invasion. The review also details uncertainties needing consideration which pertain to water quality, outbreaks, exposure time, infection sites, biofilms, cerumen, environmental factors (e.g. skin saturation, hydrodynamics), and whether P. aeruginosa is endogenous or exogenous. The review's findings are used to propose a conceptual infection model and identify research priorities including pool dose-response modelling, epidermis ecology and infection likelihood-based hygiene management. C1 [Roser, D. J.; Van den Akker, B.; Ashbolt, N. J.] Univ New S Wales, Sch Civil & Environm Engn, UNSW Water Res Ctr, Sydney, NSW 2052, Australia. [Boase, S.] Queen Elizabeth Hosp, Dept Otorhinolaryngol Head & Neck Surg, Woodville, SA 5011, Australia. [Haas, C. N.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA. [Ashbolt, N. J.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Rice, S. A.] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia. [Rice, S. A.] Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia. [Rice, S. A.] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore. [Rice, S. A.] Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore. RP Roser, DJ (reprint author), Univ New S Wales, Sch Civil & Environm Engn, UNSW Water Res Ctr, Sydney, NSW 2052, Australia. EM djroser@unsw.edu.au OI rice, scott/0000-0002-9486-2343 NR 96 TC 10 Z9 10 U1 3 U2 22 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAR PY 2014 VL 142 IS 3 BP 449 EP 462 DI 10.1017/S0950268813002690 PG 14 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AD0PZ UT WOS:000332937900001 PM 24229610 ER PT J AU Parry, IWH Evans, D Oates, WE AF Parry, Ian W. H. Evans, David Oates, Wallace E. TI Are energy efficiency standards justified? SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND MANAGEMENT LA English DT Article DE Efficiency standards; Energy taxes; Market failure; Climate; Power sector; Gasoline ID INDIVIDUAL DISCOUNT RATES; FUEL EFFICIENCY; CLIMATE-CHANGE; ECONOMICS; DURABLES; PURCHASE; FUTURE; POLICY; TAX AB This paper develops an analytical framework for comparing the welfare effects of energy efficiency standards and pricing policies for reducing gasoline, electricity, and nationwide carbon emissions. The model is parameterized with US data and includes key externalities in the energy/transportation sectors and possible underinvestment in energy efficiency due to "misperceptions" over energy savings. Even with large misperceptions, the extra welfare gains from complementing efficient pricing policies with energy efficiency standards are zero for reducing gasoline and 5 percent for reducing electricity. And when viewed as substitutes, these standards forgo 60 percent or more of the potential welfare gains from corresponding pricing policies. A combination of energy efficiency and emissions standards is more than three times as costly as carbon pricing when there is no misperception over energy savings, and even with large misperceptions, combining carbon pricing with gasoline/electricity taxes is better than combining it with energy efficiency standards. (C) 2013 Elsevier Inc. All rights reserved. C1 [Parry, Ian W. H.] Int Monetary Fund, Fiscal Affairs Dept, Washington, DC 20431 USA. [Evans, David] US EPA, Washington, DC 20460 USA. [Oates, Wallace E.] Univ Maryland, College Pk, MD 20742 USA. RP Parry, IWH (reprint author), Int Monetary Fund, Fiscal Affairs Dept, Washington, DC 20431 USA. EM iparry@imf.org NR 51 TC 6 Z9 6 U1 4 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0095-0696 EI 1096-0449 J9 J ENVIRON ECON MANAG JI J.Environ.Econ.Manage. PD MAR PY 2014 VL 67 IS 2 BP 104 EP 125 DI 10.1016/j.jeem.2013.11.003 PG 22 WC Business; Economics; Environmental Studies SC Business & Economics; Environmental Sciences & Ecology GA AD8CG UT WOS:000333493500002 ER PT J AU Rowe, MD Kreis, RG Dolan, DM AF Rowe, Mark D. Kreis, Russell G., Jr. Dolan, David M. TI A reactive nitrogen budget for Lake Michigan SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Lake Michigan; Nutrient load; Nitrogen cycling; Nitrate; Mass-balance modeling; Denitrification ID GREAT-LAKES; LOADING ANALYSIS; MASS-BALANCE; ORGANIC NITROGEN; UNITED-STATES; PHOSPHORUS; EUTROPHICATION; DEPOSITION; DENITRIFICATION; TRENDS AB The reactive (fixed) nitrogen (Nr) budget for Lake Michigan was estimated, making use of recent estimates of watershed and atmospheric nitrogen loads. Reactive N is considered to include nitrate, nitrite, ammonium, and organic N. The updated Nr load to Lake Michigan was approximately double the previous estimate from the Lake Michigan Mass Balance study for two reasons: 1) recent estimates of watershed loads were greater than previous estimates and 2) estimated atmospheric dry deposition and deposition of organic N were included in our budget. Atmospheric and watershed Nr loads were nearly equal. The estimated loss due to denitrification at the sediment surface was at least equal to, and possibly much greater than, the combined loss due to outflow and net sediment accumulation. Within the considerable uncertainty of the denitrification estimate, the budget was nearly balanced, which was consistent with the slow rate of accumulation of nitrate in Lake Michigan (similar to 1%/yr). The updated loads were used to force the LM3-PP biogeochemical water quality model. Simulated water column concentrations of nitrate and organic nitrogen in the calibrated model were consistent with available observational data when denitrification was included at the sediment surface at a rate that is consistent with literature values. The model simulation confirmed that the estimated denitrification rate does not exceed the availability of settling organic N mass. Simulated increase (decrease) in nitrate concentration was sensitive to model parameters controlling supply of sediment organic N, highlighting the importance of internal processes, not only loads, in controlling accumulation of N. (C) 2013 International Association for Great lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Rowe, Mark D.; Kreis, Russell G., Jr.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Large Lakes Res Stn, Grosse Ile, MI 48138 USA. [Dolan, David M.] Univ Wisconsin, Green Bay, WI 54311 USA. RP Rowe, MD (reprint author), 4840 S State Rd, Ann Arbor, MI 48108 USA. EM mdrowe@mtu.edu; kreis.russell@epa.gov OI Rowe, Mark/0000-0002-0852-3346 FU U.S. Environmental Protection Agency FX We wish to posthumously recognize our co-author, Dr. David M. Dolan, for his contributions to this publication and to nutrient loading studies in the Laurentian Great Lakes. His efforts on the mathematical and statistical treatment of Great Lakes phosphorus loads are widely recognized, as he was the established international expert on the topic. Less known are his recent contributions to our knowledge of nitrogen loading, 1994-2008, which is pursuant to this publication. His research has left an indelible imprint on Great Lakes ecosystem management and will influence its direction for years to come. We wish to thank Robin Dennis and Ellen Cooter, USEPA, for CMAQN deposition data. The information in this document has been funded wholly by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 51 TC 3 Z9 3 U1 9 U2 42 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD MAR PY 2014 VL 40 IS 1 BP 192 EP 201 DI 10.1016/j.jglr.2013.11.005 PG 10 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AD8XN UT WOS:000333549100021 ER PT J AU Ingwersen, W Cabezas, H Weisbrod, AV Eason, T Demeke, B Ma, X Hawkins, TR Lee, SJ Bare, JC Ceja, M AF Ingwersen, Wesley Cabezas, Heriberto Weisbrod, Anne V. Eason, Tarsha Demeke, Bayou Ma, Xin (Cissy) Hawkins, Troy R. Lee, Seung-Jin Bare, Jane C. Ceja, Manuel TI Integrated Metrics for Improving the Life Cycle Approach to Assessing Product System Sustainability SO SUSTAINABILITY LA English DT Article DE product sustainability; sustainability metrics; sustainability indicators; life cycle assessment; ecological footprint; emergy; Fisher information; green net value added; consumer products ID SAN-LUIS BASIN; IMPACT ASSESSMENT; LAND-USE; REGIONAL SUSTAINABILITY; FISHER INFORMATION; SOCIAL IMPACTS; UNITED-STATES; LCA; UNCERTAINTY; EMERGY AB Life cycle approaches are critical for identifying and reducing environmental burdens of products. While these methods can indicate potential environmental impacts of a product, current Life Cycle Assessment (LCA) methods fail to integrate the multiple impacts of a system into unified measures of social, economic or environmental performance related to sustainability. Integrated metrics that combine multiple aspects of system performance based on a common scientific or economic principle have proven to be valuable for sustainability evaluation. In this work, we propose methods of adapting four integrated metrics for use with LCAs of product systems: ecological footprint, emergy, green net value added, and Fisher information. These metrics provide information on the full product system in land, energy, monetary equivalents, and as a unitless information index; each bundled with one or more indicators for reporting. When used together and for relative comparison, integrated metrics provide a broader coverage of sustainability aspects from multiple theoretical perspectives that is more likely to illuminate potential issues than individual impact indicators. These integrated metrics are recommended for use in combination with traditional indicators used in LCA. Future work will test and demonstrate the value of using these integrated metrics and combinations to assess product system sustainability. C1 [Ingwersen, Wesley; Cabezas, Heriberto; Eason, Tarsha; Demeke, Bayou; Ma, Xin (Cissy); Hawkins, Troy R.; Lee, Seung-Jin; Bare, Jane C.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Weisbrod, Anne V.; Ceja, Manuel] Procter & Gamble Co, Global Prod Stewardship & Prod Supply, Cincinnati, OH 45268 USA. RP Ingwersen, W (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM Ingwersen.wesley@epa.gov; cabezas.heriberto@epa.gov; weisbrod.av@pg.com; eason.tarsha@epa.gov; Demeke.Bayou@epa.gov; emailma.cissy@epa.gov; hawkins.troy@epa.gov; lee.seung-jin@epa.gov; bare.jane@epa.gov; ceja.mc@pg.com OI Ingwersen, Wesley/0000-0002-9614-701X NR 86 TC 13 Z9 13 U1 3 U2 36 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD MAR PY 2014 VL 6 IS 3 BP 1386 EP 1413 DI 10.3390/su6031386 PG 28 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA AE0SC UT WOS:000333675500015 ER PT J AU Sturla, SJ Boobis, AR FitzGerald, RE Hoeng, J Kavlock, RJ Schirmer, K Whelan, M Wilks, MF Peitsch, MC AF Sturla, Shana J. Boobis, Alan R. FitzGerald, Rex E. Hoeng, Julia Kavlock, Robert J. Schirmer, Kristin Whelan, Maurice Wilks, Martin F. Peitsch, Manuel C. TI Systems Toxicology: From Basic Research to Risk Assessment SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID MINIMUM INFORMATION; MATHEMATICAL-MODEL; TOXCAST PROGRAM; IN-VITRO; METABOLOMICS; INTEGRATION; EXPOSURE; EXPOSOME; BIOLOGY; DISEASE AB Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the potential health risks associated with exposure to chemicals present in our everyday life, leading to an increasing need for more predictive and accurate risk-assessment approaches. Developing such approaches requires a detailed mechanistic understanding of the ways in which xenobiotic substances perturb biological systems and lead to adverse outcomes. Thus, Systems Toxicology approaches offer modern strategies for gaining such mechanistic knowledge by combining advanced analytical and computational tools. Furthermore, Systems Toxicology is a means for the identification and application of biomarkers for improved safety assessments. In Systems Toxicology, quantitative systems-wide molecular changes in the context of an exposure are measured, and a causal chain of molecular events linking exposures with adverse outcomes (i.e., functional and apical end points) is deciphered. Mathematical models are then built to describe these processes in a quantitative manner. The integrated data analysis leads to the identification of how biological networks are perturbed by the exposure and enables the development of predictive mathematical models of toxicological processes. This perspective integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment. C1 [Sturla, Shana J.] ETH, Inst Food Nutr & Hlth, Dept Hlth Sci & Technol, CH-8092 Zurich, Switzerland. [Boobis, Alan R.] Univ London Imperial Coll Sci Technol & Med, Dept Med, Ctr Pharmacol & Therapeut, London W12 0NN, England. [FitzGerald, Rex E.; Wilks, Martin F.] Univ Basel, Swiss Ctr Appl Human Toxicol, CH-4056 Basel, Switzerland. [Hoeng, Julia; Peitsch, Manuel C.] Philip Morris Prod SA, Philip Morris Int R&D, CH-2000 Neuchatel, Switzerland. [Kavlock, Robert J.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Schirmer, Kristin] Swiss Fed Inst Aquat Sci & Technol, Eawag, CH-8600 Dubendorf, Switzerland. [Whelan, Maurice] Commiss European Communities, DG Joint Res Ctr, Inst Hlth & Consumer Protect, I-21027 Ispra, Italy. RP Peitsch, MC (reprint author), Philip Morris Prod SA, Philip Morris Int R&D, Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland. EM manuel.peitsch@pmi.com RI Wilks, Martin/N-2150-2014; Sturla, Shana/B-4028-2015 FU Swiss National Science Foundation [136247] FX The authors are funded by their respective institutions. S. Sturla acknowledges support by the Swiss National Science Foundation (grant no. 136247). NR 93 TC 70 Z9 73 U1 10 U2 88 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD MAR PY 2014 VL 27 IS 3 SI SI BP 314 EP 329 DI 10.1021/tx400410s PG 16 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA AD3MH UT WOS:000333142700002 PM 24446777 ER PT J AU Paul, KB Hedge, JM Rotroff, DM Hornung, MW Crofton, KM Simmons, SO AF Paul, Katie B. Hedge, Joan M. Rotroff, Daniel M. Hornung, Michael W. Crofton, Kevin M. Simmons, Steven O. TI Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID HORMONE-DISRUPTING CHEMICALS; THYROID PEROXIDASE-ACTIVITY; IN-VITRO; MATERNAL HYPOTHYROXINEMIA; NEUROPSYCHOLOGICAL DEVELOPMENT; EARLY-PREGNANCY; IODINE SUPPLEMENTATION; SOY ISOFLAVONES; RISK-ASSESSMENT; MECHANISM AB High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thyroid microsomes and a fluorescent peroxidase substrate, Amplex UltraRed (AUR), were employed in an end-point assay for comparison to the existing kinetic guaiacol (GUA) oxidation assay. Following optimization of assay metrics, including Z', dynamic range, and activity, using methimazole (MMI), the assay was tested with a 21-chemical training set. The potency of MMI-induced TPO inhibition was greater with AUR compared to GUA. The dynamic range and Z' score with MMI were as follows: 127-fold and 0.62 for the GUA assay, 18-fold and 0.86 for the 96-well AUR assay, and 11.5-fold and 0.93 for the 384-well AUR assay. The 384-well AUR assay drastically reduced animal use, requiring one-tenth of the rat thyroid microsomal protein needed for the GUA 96-well format assay. Fourteen chemicals inhibited TPO, with a relative potency ranking of MMI > ethylene thiourea > 6-propylthiouracil > 2,2',4,4'-tetrahydroxy-benzophenone > 2-mercaptobenzothiazole > 3-amino-1,2,4-triazole > genistein > 4-propoxyphenol > sulfamethazine > daidzein > 4-nonylphenol > triclosan > iopanoic acid > resorcinol. These data demonstrate the capacity of this assay to detect diverse TPO inhibitors. Seven chemicals acted as negatives: 2-hydroxy-4-methoxybenzophenone, dibutylphthalate, diethylhexylphthalate, diethylphthalate, 3,5-dimethylpyrazole-1-methanol, methyl 2-methyl-benzoate, and sodium perchlorate. This assay could be used to screen large numbers of chemicals as an integral component of a tiered TH-disruptor screening approach. C1 [Paul, Katie B.] US EPA, Oak Ridge Inst Sci Educ, Res Triangle Pk, NC 27711 USA. [Paul, Katie B.; Hedge, Joan M.; Simmons, Steven O.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. [Hornung, Michael W.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Rotroff, Daniel M.; Crofton, Kevin M.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Simmons, SO (reprint author), US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. EM simmons.steve@epa.gov RI Crofton, Kevin/J-4798-2015; OI Crofton, Kevin/0000-0003-1749-9971; Simmons, Steven/0000-0001-9079-1069 FU Oak Ridge Institute for Science and Education; U.S. Environmental Protection Agency FX K.B.P. was supported by an Oak Ridge Institute for Science and Education Postdoctoral Fellowship during this work. The information in this document was funded in part by the U.S. Environmental Protection Agency. It was subjected to review by the National Health and Environmental Effects Research Laboratory and was approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names of commercial products constitute endorsement or recommendation for use. NR 76 TC 17 Z9 17 U1 5 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD MAR PY 2014 VL 27 IS 3 SI SI BP 387 EP 399 DI 10.1021/tx400310w PG 13 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA AD3MH UT WOS:000333142700008 PM 24383450 ER PT J AU Sikdar, S AF Sikdar, Subhas TI A technologist visits sustainability SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Editorial Material C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Sikdar, S (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM sikdar.subhas@epa.gov NR 0 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD MAR PY 2014 VL 16 IS 3 BP 437 EP 438 DI 10.1007/s10098-014-0731-x PG 2 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA AD4EO UT WOS:000333200100001 ER PT J AU McAlary, T Groenevelt, H Seethapathy, S Sacco, P Crump, D Tuday, M Schumacher, B Hayes, H Johnson, P Gorecki, T AF McAlary, Todd Groenevelt, Hester Seethapathy, Suresh Sacco, Paolo Crump, Derrick Tuday, Michael Schumacher, Brian Hayes, Heidi Johnson, Paul Gorecki, Tadeusz TI Quantitative passive soil vapor sampling for VOCs- part 2: laboratory experiments SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID DIFFUSIVE SAMPLER; AIR AB Controlled laboratory experiments were conducted to demonstrate the use of passive samplers for soil vapor concentration monitoring. Five different passive samplers were studied (Radiello, SKC Ultra, Waterloo Membrane Sampler, ATD tubes and 3M OVM 3500). Ten different volatile organic compounds were used of varying classes (chlorinated ethanes, ethanes, and methanes, aliphatics and aromatics) and physical properties (vapor pressure, solubility and sorption). Samplers were exposed in randomized triplicates to concentrations of 1, 10 and 100 ppm, with a relative humidity of similar to 80%, a temperature of similar to 24 degrees C, and a duration of 30 minutes in a chamber with a face velocity of about 5 cm min(-1). Passive samplers are more commonly used for longer sample durations (e.g., 8 hour workday) and higher face velocities (>600 cm min(-1)), so testing to verify the performance for these conditions was needed. Summa canister samples were collected and analyzed by EPA Method TO-15 to establish a baseline for comparison for all the passive samplers. Low-uptake rate varieties of four of the samplers were also tested at 10 ppm, under two conditions; with 5 cm min(-1) face velocity and stagnant conditions to assess whether low or near-zero face velocities would result in a low bias from the starvation effect. The results indicate that passive samplers can provide concentration measurements with accuracy (mostly within a factor of 2) and precision (RSD < 15%) comparable to conventional Summa canister samples and EPA Method TO-15 analysis. Some compounds are challenging for some passive samplers because of uncertainties in the uptake rates, or challenges with retention or recovery. C1 [McAlary, Todd; Groenevelt, Hester] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada. [McAlary, Todd; Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy. [Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England. [Tuday, Michael] Columbia Analyt Serv, Simi Valley, CA USA. [Schumacher, Brian] US EPA, Las Vegas, NV 89193 USA. [Hayes, Heidi] Eurofins Air Tox Inc, Folsom, CA USA. [Johnson, Paul] Arizona State Univ, Tempe, AZ USA. RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane,2, Guelph, ON N1G 5G3, Canada. EM tmcalary@geosyntec.com OI Gorecki, Tadeusz/0000-0001-7727-7516 FU Environmental Security Technology Certification Program (ESTCP) FX Funding for this work was provided by the Environmental Security Technology Certification Program (ESTCP). Sam Brock of AFCEC and Andrea Leeson of ESTCP were the DOD Liaisons. We gratefully acknowledge Caterina Boaretto of Fondazione Salvatore Maugeri for GC analysis of the Radiello samplers. NR 25 TC 3 Z9 3 U1 1 U2 21 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PD MAR PY 2014 VL 16 IS 3 BP 491 EP 500 DI 10.1039/c3em00128h PG 10 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA AD4NB UT WOS:000333226700014 PM 24513676 ER PT J AU McAlary, T Groenevelt, H Nicholson, P Seethapathy, S Sacco, P Crump, D Tuday, M Hayes, H Schumacher, B Johnson, P Gorecki, T Rivera-Duarte, I AF McAlary, Todd Groenevelt, Hester Nicholson, Paul Seethapathy, Suresh Sacco, Paolo Crump, Derrick Tuday, Michael Hayes, Heidi Schumacher, Brian Johnson, Paul Gorecki, Tadeusz Rivera-Duarte, Ignacio TI Quantitative passive soil vapor sampling for VOCs- part 3: field experiments SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID THERMAL-DESORPTION; DIFFUSIVE SAMPLER; AIR AB Volatile organic compounds (VOCs) are commonly associated with contaminated land and may pose a risk to human health via subsurface vapor intrusion to indoor air. Soil vapor sampling is commonly used to assess the nature and extent of VOC contamination, but can be complicated because of the wide range of geologic material permeability and moisture content conditions that might be encountered, the wide variety of available sampling and analysis methods, and several potential causes of bias and variability, including leaks of atmospheric air, adsorption desorption-interactions, inconsistent sampling protocols and varying levels of experience among sampling personnel. Passive sampling onto adsorbent materials has been available as an alternative to conventional whole-gas sample collection for decades, but relationships between the mass sorbed with time and the soil vapor concentration have not been quantitatively established and the relative merits of various commercially available passive samplers for soil vapor concentration measurement is unknown. This paper presents the results of field experiments using several different passive samplers under a wide range of conditions. The results show that properly designed and deployed quantitative passive soil vapor samplers can be used to measure soil vapor concentrations with accuracy and precision comparable to conventional active soil vapor sampling (relative concentrations within a factor of 2 and RSD comparable to active sampling) where the uptake rate is low enough to minimize starvation and the exposure duration is not excessive for weakly retained compounds. C1 [McAlary, Todd; Groenevelt, Hester; Nicholson, Paul] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada. [McAlary, Todd; Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy. [Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England. [Tuday, Michael] Columbia Analyt Serv, Simi Valley, CA USA. [Hayes, Heidi] Eurofins Air Tox Inc, Folsom, CA USA. [Schumacher, Brian] US EPA, Las Vegas, NV USA. [Johnson, Paul] Arizona State Univ, Tempe, AZ USA. [Rivera-Duarte, Ignacio] SPAWAR Syst Ctr Pacific, San Diego, CA USA. RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane,2, Guelph, ON N1G 5G3, Canada. EM tmcalary@geosyntec.com OI Gorecki, Tadeusz/0000-0001-7727-7516 FU Environmental Security Technology Certification. Program (ESTCP); Air Force Civil Engineering Center; ESTCP as the DOD Liaisons; U.S. Navy SPAWAR Systems Center Pacific under the Improved Assessment Strategies for the Vapor Intrusion project; Navy's Environmental Sustainability Development to Integration (NESDI) Program FX Funding for this work was provided by the Environmental Security Technology Certification. Program (ESTCP) with Sam Brock of the Air Force Civil Engineering Center and Andrea Leeson of ESTCP as the DOD Liaisons and the U.S. Navy SPAWAR Systems Center Pacific under the Improved Assessment Strategies for the Vapor Intrusion project, which is funded by the Navy's Environmental Sustainability Development to Integration (NESDI) Program under subcontract to Richard Brady and Associates and Computer Sciences Corporation with Bart Chadwick and Ignacio Rivera-Duarte as contracting officers. We gratefully acknowledge Arizona State University and Mike Singletary of Naval Air Station Jacksonville for assistance and site access for sample collection and Caterina Boaretto of Fondazione Salvatore Maugeri for GC analysis of the Radiello samplers. NR 19 TC 2 Z9 2 U1 3 U2 29 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PD MAR PY 2014 VL 16 IS 3 BP 501 EP 510 DI 10.1039/c3em00653k PG 10 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA AD4NB UT WOS:000333226700015 PM 24513784 ER PT J AU Sun, HF Shi, BY Lytte, DA Bai, YH Wang, DS AF Sun, Huifang Shi, Baoyou Lytte, Darren A. Bai, Yaohui Wang, Dongsheng TI Formation and release behavior of iron corrosion products under the influence of bacterial communities in a simulated water distribution system SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID DRINKING-WATER; REDUCING BACTERIA; STAINLESS-STEEL; PHYSICOCHEMICAL CHARACTERISTICS; LOCALIZED CORROSION; FE(II) OXIDATION; DISSOLVED-OXYGEN; PIPE CORROSION; SP NOV.; SCALES AB To understand the formation and release behavior of iron corrosion products in a drinking water distribution system, annular reactors (ARs) were used to investigate the development processes of corrosion products and biofilm community as welt as the concomitant iron release behavior. Results showed that the formation and transformation of corrosion products and bacterial community are closely related to each other. The presence of sulfate-reducing bacteria (SRB, e.g. Desulfovibrio and Desulfotomaculum), sulfur-oxidizing bacteria (SOB, e.g. Sulfuricella), and iron-oxidizing bacteria (IOB, e.g. Acidovorax, Gallionella, Leptothrix, and Sphaerotilus) in biofilms could speed up iron corrosion; however, iron-reducing bacteria (IRB, e.g. Bacillus, Clostridium, and Pseudomonas) could inhibit iron corrosion and iron release. Corrosion scales on iron coupons could develop into a two-layered structure (top layer and inner layer) with time. The relatively stable constituents such as goethite (alpha-FeOOH) and magnetite (Fe3O4) mainly existed in the top layers, while green rust (Fe-6(OH)(12)CO3) mainly existed in the inner layers. The IOB (especially Acidovorax) contributed to the formation of alpha-FeOOH, white IRB and the anaerobic conditions could facilitate the formation of Fe3O4. Compared with the AR test without biofilms, the iron corrosion rate with biofilms was relatively higher (p < 0.05) during the whole experimental period, but the iron release with biofilms was obviously lower both at the initial stage and after 3 months. Biofilm and corrosion scale samples formed under different water supply conditions in an actual drinking water distribution system verified the relationships between the bacterial community and corrosion products. C1 [Sun, Huifang; Shi, Baoyou; Bai, Yaohui; Wang, Dongsheng] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China. [Lytte, Darren A.] US EPA, Cincinnati, OH 45268 USA. RP Shi, BY (reprint author), Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, 18 Shuangqing Rd,POB 2871, Beijing 100085, Peoples R China. EM byshi@rcees.ac.cn FU National Natural Science Foundation of China [51178450, 51378493]; National Water Pollution Control and Treatment Special Key Project of China [2012ZX07404-002, 2012ZX07408-002] FX This work was financially supported by National Natural Science Foundation of China (no. 51178450 and no. 51378493) and National Water Pollution Control and Treatment Special Key Project of China (2012ZX07404-002, 2012ZX07408-002). NR 48 TC 5 Z9 9 U1 4 U2 59 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PD MAR PY 2014 VL 16 IS 3 BP 576 EP 585 DI 10.1039/c3em00544e PG 10 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA AD4NB UT WOS:000333226700024 PM 24509822 ER PT J AU Ingwersen, WW Subramanian, V AF Ingwersen, Wesley W. Subramanian, Vairavan TI Guidance for product category rule development: process, outcome, and next steps SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT LA English DT Article DE Alignment; Environmental product declarations; Product category rules; Product claims; Product footprints ID ALIGNMENT AB Purpose The development of product category rules (PCRs) is inconsistent among the program operators using ISO 14025 as the basis. Furthermore, the existence of several other product claim standards and specifications that require analogous rules for making product claims has the potential to reduce any consistency in PCRs present in the ISO 14025 domain and result in unnecessary duplication of PCRs. These inconsistencies and duplications can be attributed to (a) insufficient specificity in related standards, (b) the presence of several standards and specifications, (c) lack of/limited coordination among program operators, and (d) lack of a single global database for PCRs. As a result, current PCR development threatens the legitimacy of life cycle assessment-based product claims. Process Through discussions over the past few years, in multistakeholder organizations, it has become clear that more guidance on the development of PCRs is necessary. In response to this need, the Product Category Rule Guidance Development Initiative (www.pcrguidance.org) was launched as an independent multistakeholder effort in early 2012. The premise for the Initiative was that the Guidance would be created by a voluntary group of international stakeholders that would share ownership of the outputs. Outcome The Guidance is now published, along with supplementary materials, on the Initiative website. The guidance document specifies requirements, recommendations, and options on (1) steps to be taken before PCR creation; (2) elements of a PCR; (3) review, publication, and use of PCRs; and (4) best practices for PCR development and management. Supplementary materials include a PCR template, a conformity assessment form, and a list of program operators from around the world. Conclusions The Guidance will help reduce cost and time to develop a PCR by supporting the adaptation of an existing PCR or by building on elements from existing PCRs. It will help reduce confusion and frustration when creating PCRs that are based on one or more standards and programs. Overall, the Guidance is a robust handbook for consistency and clarity in the development of PCRs. C1 [Ingwersen, Wesley W.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Subramanian, Vairavan] PRe North Amer, Washington, DC 20001 USA. RP Ingwersen, WW (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26 W Martin Luther King Dr,MS-483, Cincinnati, OH 45268 USA. EM Ingwersen.Wesley@epamail.epa.gov; ingwersen.wesley@epa.gov OI Ingwersen, Wesley/0000-0002-9614-701X NR 20 TC 5 Z9 5 U1 1 U2 6 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0948-3349 EI 1614-7502 J9 INT J LIFE CYCLE ASS JI Int. J. Life Cycle Assess. PD MAR PY 2014 VL 19 IS 3 BP 532 EP 537 DI 10.1007/s11367-013-0659-0 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AD4FU UT WOS:000333204200007 ER PT J AU Davis, MJ Janke, R Magnuson, ML AF Davis, Michael J. Janke, Robert Magnuson, Matthew L. TI A Framework for Estimating the Adverse Health Effects of Contamination Events in Water Distribution Systems and its Application SO RISK ANALYSIS LA English DT Article DE drinking water; contamination events; terrorist attacks; Consequence analysis; water distribution systems ID DRINKING-WATER; ENVIRONMENTAL-CONDITIONS; MODEL; ORGANOPHOSPHORUS; PESTICIDES; EXPOSURE; IMPACTS AB Intentional or accidental releases of contaminants into a water distribution system (WDS) have the potential to cause significant adverse health effects among individuals consuming water from the system. A flexible analysis framework is presented here for estimating the magnitude of such potential effects and is applied using network models for 12 actual WDSs of varying sizes. Upper bounds are developed for the magnitude of adverse effects of contamination events in WDSs and evaluated using results from the 12 systems. These bounds can be applied in cases in which little system-specific information is available. The combination of a detailed, network-specific approach and a bounding approach allows consequence assessments to be performed for systems for which varying amounts of information are available and addresses important needs of individual utilities as well as regional or national assessments. The approach used in the analysis framework allows contaminant injections at any or all network nodes and uses models that (1)account for contaminant transport in the systems, including contaminant decay, and (2)provide estimates of ingested contaminant doses for the exposed population. The approach can be easily modified as better transport or exposure models become available. The methods presented here provide the ability to quantify or bound potential adverse effects of contamination events for a wide variety of possible contaminants and WDSs, including systems without a network model. C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne, IL 60439 USA. [Janke, Robert; Magnuson, Matthew L.] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA. EM mike_davis@anl.gov FU U.S. Environmental Protection Agency's (EPA) Office of Research and Development; EPA under U.S. Department of Energy [DE-AC02-06CH11357] FX The U.S. Environmental Protection Agency's (EPA) Office of Research and Development funded, managed, and participated in the research described here under an interagency agreement. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of EPA. Work at Argonne National Laboratory was sponsored by the EPA under interagency agreement through U.S. Department of Energy Contract DE-AC02-06CH11357. An anonymous reviewer suggested the use of a simple mass-based bounding model. All postsimulation data analysis and preparation of graphics for this article were done using R.(35) NR 35 TC 3 Z9 3 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD MAR PY 2014 VL 34 IS 3 BP 498 EP 513 DI 10.1111/risa.12107 PG 16 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA AD3MK UT WOS:000333143000008 PM 24102461 ER PT J AU Van Houtven, G Mansfield, C Phaneuf, DJ von Haefen, R Milstead, B Kenney, MA Reckhow, KH AF Van Houtven, George Mansfield, Carol Phaneuf, Daniel J. von Haefen, Roger Milstead, Bryan Kenney, Melissa A. Reckhow, Kenneth H. TI Combining expert elicitation and stated preference methods to value ecosystem services from improved lake water quality SO ECOLOGICAL ECONOMICS LA English DT Article DE Ecosystem services valuation; Water quality; Expert elicitation; Stated preference; Water quality modeling ID WILLINGNESS-TO-PAY; CONTINGENT-VALUATION; RESOURCE IMPROVEMENTS; NUTRIENT CRITERIA; UNITED-STATES; METAANALYSIS; BIASES; GOODS AB With increasing attention on the contribution of ecosystems to human well-being, there is a need for tools that integrate ecological and economic models for valuing ecosystem services. To address this, we develop a protocol for linking ecological processes and outcomes to human preferences, which combines environmental modeling, expert elicitation, and nonmarket valuation methods. Our application values reductions in nutrient loads to lakes in the southeastern US. The innovation centers on how biochemical measures of water quality (e.g., chlorophyll a) are translated into terms that are meaningful to individuals who derive ecosystem services from them. Using expert elicitation data, we estimate a model linking changes in biochemical measures to an index of eutrophication in lakes. We then develop a stated preference survey including (a) detailed descriptions of the perceptible outcomes - e.g., water color, clarity - associated each eutrophication index level; and (b) policy scenarios involving state-level changes in lake eutrophication conditions. We estimate a function that predicts households' willingness to pay for changes in lake water quality. We demonstrate the protocol through a case study examining the benefits of lake quality improvement in Virginia as a result of recent policies to reduce nutrient loads in the Chesapeake Bay watershed. (C) 2014 Elsevier B.V. All rights reserved. C1 [Van Houtven, George; Mansfield, Carol] RTI Int, Res Triangle Pk, NC USA. [Phaneuf, Daniel J.] Univ Wisconsin, Madison, WI 53706 USA. [von Haefen, Roger] N Carolina State Univ, Raleigh, NC 27695 USA. [Milstead, Bryan] US EPA, Washington, DC USA. [Kenney, Melissa A.] Univ Maryland, College Pk, MD 20742 USA. [Reckhow, Kenneth H.] Duke Univ, Durham, NC 27706 USA. RP Phaneuf, DJ (reprint author), Univ Wisconsin Madison, Dept Agr & Appl Econ, Madison, WI 53706 USA. EM dphaneuf@wisc.edu OI Kenney, Melissa/0000-0002-2121-8135 NR 43 TC 8 Z9 8 U1 9 U2 65 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8009 EI 1873-6106 J9 ECOL ECON JI Ecol. Econ. PD MAR PY 2014 VL 99 BP 40 EP 52 DI 10.1016/j.ecolecon.2013.12.018 PG 13 WC Ecology; Economics; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology; Business & Economics GA AC8YL UT WOS:000332820900005 ER PT J AU Griffith, MB AF Griffith, Michael B. TI Natural variation and current reference for specific conductivity and major ions in wadeable streams of the conterminous USA SO FRESHWATER SCIENCE LA English DT Article DE specific conductivity; calcium; magnesium; sodium; potassium; bicarbonate; sulfate; chloride; ecoregions; geographic variation; current reference; wadeable streams ID EASTERN UNITED-STATES; WORLD WATER CHEMISTRY; EVAPORATION-CRYSTALLIZATION PROCESS; FRESH-WATER; MID-ATLANTIC; RIVER-BASIN; CLASSIFICATION SCHEMES; CHEMICAL-COMPOSITION; NUTRIENT CRITERIA; SURFACE WATERS AB Variation in specific conductivity and major ions in streams must be understood to assess the effects of changes in ionic strength and salinity on stream biota. I compiled data for randomly selected sites from surveys conducted from 1985 to 2009 by the US Environmental Protection Agency (EPA). I followed EPA methods to estimate reference values for specific conductivity (60 ecoregions) and each major ion (34 ecoregions) as the 25th percentile of values in 1st- to 4th-order streams in Level III ecoregions with data from >= 25 sites (85 ecoregions). The 25th percentiles of specific conductivity were <200 mu S/cm for most eastern and western montane ecoregions, except those dominated by limestone or calcareous till. Arid western ecoregions had higher specific conductivities. Ca2+ was generally the most abundant cation followed by Mg2+, Na+, and K+. HCO3- was generally the most abundant anion followed by SO42- and Cl-. Ecoregions where SO42- or Cl-concentrations were greater than HCO3- concentration have been affected by acidic precipitation or are influenced by marine air masses, respectively, and have very low specific conductivities. Patterns of variation appear to be associated with 3 processes controlling total and relative concentrations of major ions in freshwaters. In many ecoregions, relative ionic concentrations reflect underlying geology, but in arid ecoregions, relative ionic concentrations show concentration by evaporation. Relative ionic concentrations in coastal ecoregions and those affected by acidic precipitation reflect the ionic content of precipitation. Verification of these factors awaits better quantification of the geological and climatic characteristics of each ecoregion. C1 US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. RP Griffith, MB (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, MS A-130,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM griffith.michael@epa.gov NR 108 TC 14 Z9 14 U1 0 U2 30 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2014 VL 33 IS 1 BP 1 EP 17 DI 10.1086/674704 PG 17 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AC2IC UT WOS:000332322400001 ER PT J AU Stein, ED White, BP Mazor, RD Jackson, JK Battle, JM Miller, PE Pilgrim, EM Sweeney, BW AF Stein, Eric D. White, Bryan P. Mazor, Raphael D. Jackson, John K. Battle, Juliann M. Miller, Peter E. Pilgrim, Erik M. Sweeney, Bernard W. TI Does DNA barcoding improve performance of traditional stream bioassessment metrics? SO FRESHWATER SCIENCE LA English DT Article DE DNA barcoding; bioassessment; stressor-response; metric evaluation; streambank armoring ID TAXONOMIC RESOLUTION; MULTIMETRIC INDEXES; COMPLEX DIPTERA; BIODIVERSITY; QUALITY; MACROINVERTEBRATES; IDENTIFICATIONS; ASSESSMENTS; CHALLENGES; SIMULIIDAE AB Benthic macroinvertebrate community composition is used to assess wetland and stream condition and to help differentiate the effects of stressors among sites. Deoxyribonucleic acid (DNA) barcoding has been promoted as a way to increase taxonomic resolution and, thereby, to increase the sensitivity of bioassessment metrics. We compared the ability of several commonly used bioassessment metrics calculated with data derived from morphology and from DNA barcoding to detect differences in stream condition of 6 paired sites in southern California with relatively subtle impacts to habitat. At each site, we sampled an upstream (reference) reach and a downstream (impact) reach with armored stream banks. We counted and identified similar to 600 organisms/ sample based on morphology (generally to species, but to genus for midges). We then extracted mitochondrial (mt) DNA from each individual and sequenced the similar to 658-base pair (bp) barcoding region of the cytochrome c oxidase subunit I (COI) gene. Most (91%) organisms yielded sequences > 350 bp in length, but high failure rates for all taxa collected from 1 stream required that we exclude it from analysis. Sixteen metrics calculated with morphological data showed subtle but not significant differences in community composition between armored and unarmored reaches. The statistical power of 10 of the 16 metrics was substantially higher when calculated with DNA than with morphological data, and we were able to discern differences between armored and unarmored reaches with the DNA data. These differences were associated with increased taxonomic richness detected for midges, mayflies, noninsects, caddisflies, and black flies when DNA data were used. Our results suggest that identifications based on DNA barcoding have the potential to improve power to detect small changes in stream condition. C1 [Stein, Eric D.; White, Bryan P.; Mazor, Raphael D.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Jackson, John K.; Battle, Juliann M.; Sweeney, Bernard W.] Stroud Water Res Ctr, Avondale, PA 19311 USA. [Miller, Peter E.] Univ Guelph, Biodivers Inst Ontario, Canadian Ctr DNA Barcoding, Guelph, ON N1G 2W1, Canada. [Pilgrim, Erik M.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Stein, ED (reprint author), Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. EM erics@sccwrp.org; byranw@sccwrp.org; raphaelm@sccwrp.org; jkjackson@stroudcenter.org; jbattle@stroudcenter.org; pemiller@uoguelph.ca; pilgrim.erik@epa.gov; sweeney@stroudcenter.org RI Stein, Eric/A-9362-2008 OI Stein, Eric/0000-0002-4729-809X FU Pennswood Endowment Fund; Stroud Water Research Center Endowment Funds FX We thank the teams from all institutions that cooperated to carry out this work. Kristin Smith of the Southern California Coastal Water Research Project (SCCWRP) was instrumental in site selection, reconnaissance, and field work. We thank Jeff Brown and Greg Lyon of SCCWRP for assistance with field work. Field assistance with BMI sampling was provided by California State University (CSU) Stanislaus students Veronica Menendez, Tamera Rogers, and Brittany Bjelde. Taxonomic expertise for benthic macroinvertebrates was provided by Daniel Pickard and the staff at the Department of Fish and Game Aquatic Bioassessment Laboratory at CSU Chico. Chris Solek provided assistance in interpreting the black fly data. Sequencing of the DNA barcodes was graciously provided by the Canadian Centre for DNA Barcoding with support from the Life Technologies Corporation. Funding for JKJ, JMB, and BWS was provided by the Pennswood Endowment Fund and the Stroud Water Research Center Endowment Funds. NR 45 TC 9 Z9 9 U1 1 U2 39 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2014 VL 33 IS 1 BP 302 EP 311 DI 10.1086/674782 PG 10 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AC2IC UT WOS:000332322400026 ER PT J AU Jackson, JK Battle, JM White, BP Pilgrim, EM Stein, ED Miller, PE Sweeney, BW AF Jackson, John K. Battle, Juliann M. White, Bryan P. Pilgrim, Erik M. Stein, Eric D. Miller, Peter E. Sweeney, Bernard W. TI Cryptic biodiversity in streams: a comparison of macroinvertebrate communities based on morphological and DNA barcode identifications SO FRESHWATER SCIENCE LA English DT Article DE DNA barcoding; cytochrome c oxidase; COI gene; mitochondrial DNA; freshwater; macroinvertebrates; water-quality monitoring; community structure; species richness; taxonomy ID TAXONOMIC RESOLUTION; SPECIES-DELIMITATION; MITOCHONDRIAL-DNA; WATER-QUALITY; COMPLEX EPHEMEROPTERA; NORTHERN CALIFORNIA; GENETIC-STRUCTURE; REFERENCE LIBRARY; AQUATIC INSECTS; SOUTH-CAROLINA AB Species-level identifications are difficult or impossible for many larval aquatic macroinvertebrates. We described the taxonomic composition of macroinvertebrate communities from 5 coastal streams in 3 neighboring catchments in southern California. We compared taxonomic identifications based on deoxyribonucleic acid (DNA) barcoding (cytochrome c oxidase subunit I [ COI]) with morphological identifications of the same specimens. We examined 5870 individuals, and barcodes with sequence lengths > 350 base pairs (bp) for 91% of those specimens. We used the naturally occurring gaps in divergence frequencies for each order (usually 2% level of genetic divergence) to delimit putative species for all taxonomic groups except Simulium (3%) and Baetis (1%). We identified 200 species across these 5 streams. We identified 104 more species via barcodes than via morphology (200 vs 96, a 108% increase). Richness increases were greatest for Chironomidae (60 more species), Ephemeroptera (10 species), Acari (10 species), and Trichoptera (6 species). Forty-five percent of the genera/ species identified morphologically represented > 2 species. Many (86) species identified with barcodes were represented by only 1 or 2 specimens and were found at only 1 stream. Thus, species rarity (either spatially or numerically) appears to be a common characteristic of these streams. Barcoding increased total richness at each site by 12 to 40 taxa over morphology alone, and increased the difference between reference and impact sites in terms of lost taxa. These results suggest that macroinvertebrate biodiversity in streams has been underestimated substantially in the past, as has the biodiversity lost in response to environmental stress. The potential of DNA barcoding will not be fully realized until we can assign traits, such as habitat preference, ecological function, and pollution tolerance, at the species level. C1 [Jackson, John K.; Battle, Juliann M.; Sweeney, Bernard W.] Stroud Water Res Ctr, Avondale, PA 19311 USA. [White, Bryan P.; Stein, Eric D.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Pilgrim, Erik M.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Miller, Peter E.] Univ Guelph, Biodivers Inst Ontario, Canadian Ctr DNA Barcoding, Guelph, ON N1G 2W1, Canada. RP Jackson, JK (reprint author), Stroud Water Res Ctr, Avondale, PA 19311 USA. EM jkjackson@stroudcenter.org; jbattle@stroudcenter.org; bryan2@sccwrp.org; pilgrim.erik@epamail.epa.gov; erics@sccwrp.org; pemiller@uoguelph.ca; sweeney@stroudcenter.org RI Stein, Eric/A-9362-2008; OI Stein, Eric/0000-0002-4729-809X; White, Bryan/0000-0003-4191-3511 FU Life Technologies Corporation; US Environmental Protection Agency in Cincinnati, Ohio; Stroud Water Research Center; Southern California Coastal Water Research Project; Pennswood Endowment Fund; Stroud Water Research Center Endowment Funds FX We thank Kristin Smith, Jeff Brown, and Greg Lyon of Southern California Coastal Water Research Project for assistance with macroinvertebrate collections, with added assistance from California State University Stanislaus students Veronica Menendez, Tamera Rogers, and Brittany Bjelde. Morphological identifications were provided by Daniel Pickard and the staff at the Department of Fish and Game Aquatic Bioassessment Laboratory at California State University Chico. Stephanie Liguori of the Stroud Water Research Center was responsible for preparing DNA samples for processing. Sequencing of the DNA barcodes was done by the Canadian Centre for DNA Barcoding with funds from the Life Technologies Corporation, and at the US Environmental Protection Agency in Cincinnati, Ohio. Melanie Arnold of the Stroud Water Research Center helped with statistical programming and analyses. We thank Associate Editor Michael T. Monaghan and 2 anonymous referees for comments that improved an earlier version of this manuscript. Support for work at the Stroud Water Research Center was provided by Southern California Coastal Water Research Project, the Pennswood Endowment Fund, and the Stroud Water Research Center Endowment Funds. This is Stroud Contribution NR 82 TC 14 Z9 15 U1 3 U2 60 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2014 VL 33 IS 1 BP 312 EP 324 DI 10.1086/675225 PG 13 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AC2IC UT WOS:000332322400027 ER PT J AU White, BP Pilgrim, EM Boykin, LM Stein, ED Mazor, RD AF White, Bryan P. Pilgrim, Erik M. Boykin, Laura M. Stein, Eric D. Mazor, Raphael D. TI Comparison of four species-delimitation methods applied to a DNA barcode data set of insect larvae for use in routine bioassessment SO FRESHWATER SCIENCE LA English DT Article DE DNA barcoding; bioassessment; biomonitoring; species delimitation; coalescent theory; cytochrome; oxidase I; COI; benthic macroinvertebrates; GMYC ID BIOLOGICAL IDENTIFICATIONS; GENE TREES; EPHEMEROPTERA; TAXONOMY; MACROINVERTEBRATES; BIODIVERSITY; TRICHOPTERA; INVENTORY; DIVERSITY; INFERENCE AB Species delimitation (grouping individuals into distinct taxonomic groups) is an essential part of evolutionary, conservation, and molecular ecology. Deoxyribonucleic acid (DNA) barcodes, short fragments of the cytochrome c oxidase subunit I (COI) gene, are being used in environmental bioassessments to assign specimens to putative species, but no method for delimiting DNA barcodes into species-level entities is universally accepted. We investigated the effect of delimitation methods on outcomes of bioassessments based on DNA barcodes. We used 2 tree-construction methods (neighbor joining [NJ], maximum likelihood [ML]) and 4 classes of species-delimitation criteria (distance-based, bootstrap support, reciprocal monophyly, and coalescentbased) with a DNA barcode data set consisting of 3 genera and 2202 COI sequences. We compared species delimitations for Baetis (Ephemeroptera: Baetidae), Eukiefferiella (Diptera: Chironomidae), and Simulium (Diptera: Simuliidae) from different streams. We assessed congruence among trees and compared species abundances and estimated species richness among methods. NJ followed by use of a standard barcoding distance cutoff (2%) yielded the greatest number of putative species. All other delimitation methods yielded similar, but lower, richness. Differences in species delimitations produced by various methods might have been caused by confounding factors, such as possible parthenogenesis in Baetis and rare haplotypes in abundant species of Baetis and Simulium. Eukiefferiella presented the fewest discrepancies among delimitations. Each method can be regarded as producing a separate line of evidence contributing to the delimitation of separately evolving lineages. The increased resolution offered by DNA barcoding can yield important insights into the natural history of organisms, but the power of these observations is limited without the use of multigene and multilocus data sets. Key words: DNA barcoding, bioassessment, biomonitoring, species delimitation, coalescent theory, cytochrome C1 [White, Bryan P.; Stein, Eric D.; Mazor, Raphael D.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Pilgrim, Erik M.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Boykin, Laura M.] Univ Western Australia, ARC Ctr Excellence, Crawley, WA 6009, Australia. RP White, BP (reprint author), Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. EM bryanw@sccwrp.org; pilgrim.erik@epa.gov; lboykin@mac.com; erics@sccwrp.org; raphaelm@sccwrp.org RI Stein, Eric/A-9362-2008; Boykin, Laura/H-8876-2014; OI Stein, Eric/0000-0002-4729-809X; Boykin, Laura/0000-0002-6101-1921; White, Bryan/0000-0003-4191-3511 FU Life Technologies Corporation FX We thank Tomochika Fujisawa for providing an advance release copy of the Species List script essential to the coalescent delimitation analysis. We are also thankful to Daniel Pickard for providing taxonomic expertise and valuable feedback on Baetis species identifications. We are grateful to the Canadian Centre for DNA Barcoding, which provided sequencing with support from the Life Technologies Corporation. We also thank the 2 anonymous referees for their feedback which greatly improved the quality of the manuscript. NR 67 TC 5 Z9 5 U1 1 U2 52 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2014 VL 33 IS 1 BP 338 EP 348 DI 10.1086/674982 PG 11 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AC2IC UT WOS:000332322400029 ER PT J AU Gilchrist, S Borst, M Stander, EK AF Gilchrist, Sivajini Borst, Michael Stander, Emilie K. TI Factorial Study of Rain Garden Design for Nitrogen Removal SO JOURNAL OF IRRIGATION AND DRAINAGE ENGINEERING LA English DT Article DE Carbon source; Sandy media; Rain gardens; Urban storm-water runoff; Nitrate removal; Nitrogen ID BIORETENTION; OPTIMIZATION; MANAGEMENT; RETENTION; NITRATE; RUNOFF; MEDIA AB Nitrate (NO3--N) removal studies in rain gardens show great variability in removal rates, and in some cases NO3--N was exported. A three-way factorial design (2x2x4) was devised for eight outdoor unvegetated rain gardens to evaluate the effects of hydraulic loading (two sizes and two flow rates), the presence/absence of a buried wood chip layer (2), and the presence/absence of a subsurface saturated zone (SZ) (2) on nitrate-nitrite (NO3--NO2-) removal. Captured stormwater runoff was used in this study. Results showed that the presence of a SZ reduced the NO3--NO2- mass by 75% compared to a 7% reduction without this zone. The presence of a SZ significantly decreased ammonia-N (NH3-N) mass reduction (p<0.00001). The difference in total nitrogen (TN) mass reduction with the introduced SZ was not significant, largely due to NO3--NO2- mass reduction that was offset by NH3-N mass increases in rain gardens with the SZ. The buried wood chip layer showed no significant effect on N removal. No significant interactions were found between the factors. Overall, the results in this study highlight the importance of incorporating a subsurface SZ for NO3--NO2- load reduction and demonstrate that a buried wood chip layer as a carbon source did not make a significant contribution to N removal. C1 [Gilchrist, Sivajini] Hudson Cty Community Coll, Hlth Sci & Technol Div, Jersey City, NJ 07306 USA. [Borst, Michael] US EPA, Urban Watershed Management Branch, Edison, NJ 08837 USA. [Stander, Emilie K.] Raritan Valley Community Coll, Dept Sci & Engn, Branchburg, NJ 08876 USA. RP Gilchrist, S (reprint author), Hudson Cty Community Coll, Hlth Sci & Technol Div, Jersey City, NJ 07306 USA. EM sgilchrist@hccc.edu FU EPA [EP-C-10-054]; Office of Research and Development, USEPA FX The manuscript benefited greatly from the recommendations of anonymous reviewers. The authors thank Dr. Jake Beaulieu (USEPA, Cincinnati) and Maureen Krudner (USEPA, New York) for their review of the draft manuscript. Appreciation is also extended to PARS Environmental for sample collection under EPA Contract EP-C-10-054. This research was conducted at the USEPA's Urban Watershed Management Branch in Edison, New Jersey, with support funds from the Office of Research and Development, USEPA. The corresponding author wishes to extend much gratitude to the Oak Ridge Institute of Science and Education, Tennessee, for the opportunity to work as a postdoctoral fellow at the research site. NR 33 TC 2 Z9 3 U1 6 U2 50 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9437 EI 1943-4774 J9 J IRRIG DRAIN ENG JI J. Irrig. Drainage Eng-ASCE PD MAR 1 PY 2014 VL 140 IS 3 DI 10.1061/(ASCE)IR.1943-4774.0000678 PG 11 WC Agricultural Engineering; Engineering, Civil; Water Resources SC Agriculture; Engineering; Water Resources GA AC6TK UT WOS:000332657700010 ER PT J AU Wang, WN Soulis, J Yang, YJ Biswas, P AF Wang, Wei-Ning Soulis, Johnathon Yang, Y. Jeffrey Biswas, Pratim TI Comparison of CO2 Photoreduction Systems: A Review SO AEROSOL AND AIR QUALITY RESEARCH LA English DT Review DE Fossil fuels; Global warming; Photocatalysis; Solar energy; Nanotechnology ID CARBON-DIOXIDE FIXATION; ENHANCED PHOTOCATALYTIC ACTIVITY; VISIBLE-LIGHT IRRADIATION; GEL DERIVED TITANIA; SCENEDESMUS-OBLIQUUS; TIO2 POWDERS; TUBULAR PHOTOBIOREACTOR; ELECTRONIC-STRUCTURE; HYDROCARBON FUELS; SURFACE-CHEMISTRY AB Carbon dioxide (CO2) emissions are a major contributor to the climate change equation, and thus strategies need to be developed in order to reduce increases in CO2 levels in the atmosphere. One of the most promising approaches is to convert CO2 into useful products in engineered processes. The photocatalytic reduction of CO2 into hydrocarbon fuels is a promising way to recycle CO2 as a fuel feedstock by taking advantage of the readily available solar energy. This article reviews the basics of CO2 photoreduction mechanisms, limiting steps, possible strategies to enhance photoreduction efficiency, and the state-of-the-art photocatalytic systems for CO2 reduction. In particular, a comparison between different catalytic systems, including biological (plants and algae), inorganics (semiconductors), organics (molecular complexes), and hybrid (enzyme/semiconductors) systems is provided. C1 [Wang, Wei-Ning; Soulis, Johnathon; Biswas, Pratim] Washington Univ, Dept Energy Environm & Chem Engn, Aerosol & Air Qual Res Lab, St Louis, MO 63130 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Biswas, P (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, Aerosol & Air Qual Res Lab, St Louis, MO 63130 USA. EM pbiswas@wustl.edu RI Wang, Wei-Ning/B-3005-2008 OI Wang, Wei-Ning/0000-0002-1935-6301 FU Consortium for Clean Coal Utilization (CCCU) at Washington University in St. Louis; Nano Research Facility (NRF, NSF-NNIN) at Washington University in St. Louis; USEPA [EP-011-006] FX The authors would like to acknowledge the support from the Consortium for Clean Coal Utilization (CCCU) at Washington University in St. Louis. Partial support from the Nano Research Facility (NRF, a member of NSF-NNIN) at Washington University in St. Louis is greatly acknowledged. Partial support from USEPA through Pegasus contract EP-011-006 is acknowledged. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. NR 113 TC 25 Z9 25 U1 21 U2 199 PU TAIWAN ASSOC AEROSOL RES-TAAR PI TAICHUNG COUNTY PA CHAOYANG UNIV TECH, DEPT ENV ENG & MGMT, PROD CTR AAQR, NO 168, JIFONG E RD, WUFONG TOWNSHIP, TAICHUNG COUNTY, 41349, TAIWAN SN 1680-8584 EI 2071-1409 J9 AEROSOL AIR QUAL RES JI Aerosol Air Qual. Res. PD MAR PY 2014 VL 14 IS 2 BP 533 EP 549 DI 10.4209/aaqr.2013.09.0283 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA AC7CW UT WOS:000332685800008 ER PT J AU Goldsmith, MR Grulke, CM Brooks, RD Transue, TR Tan, YM Frame, A Egeghy, PP Edwards, R Chang, DT Tornero-Velez, R Isaacs, K Wang, A Johnson, J Holm, K Reich, M Mitchell, J Vallero, DA Phillips, L Phillips, M Wambaugh, JF Judson, RS Buckley, TJ Dary, CC AF Goldsmith, M. -R. Grulke, C. M. Brooks, R. D. Transue, T. R. Tan, Y. M. Frame, A. Egeghy, P. P. Edwards, R. Chang, D. T. Tornero-Velez, R. Isaacs, K. Wang, A. Johnson, J. Holm, K. Reich, M. Mitchell, J. Vallero, D. A. Phillips, L. Phillips, M. Wambaugh, J. F. Judson, R. S. Buckley, T. J. Dary, C. C. TI Development of a consumer product ingredient database for chemical exposure screening and prioritization SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Chemical exposure; Consumer products; Ingredients; Product formulation; Near field exposure; Exposure prioritization ID SEMIVOLATILE ORGANIC-COMPOUNDS; INDOOR ENVIRONMENT; RISK-ASSESSMENT; INTAKE FRACTION; POLLUTANTS; AIR; RESOURCE; MODELS; AGENCY; DUST AB Consumer products are a primary source of chemical exposures, yet little structured information is available on the chemical ingredients of these products and the concentrations at which ingredients are present. To address this data gap, we created a database of chemicals in consumer products using product Material Safety Data Sheets (MSDSs) publicly provided by a large retailer. The resulting database represents 1797 unique chemicals mapped to 8921 consumer products and a hierarchy of 353 consumer product "use categories" within a total of 15 top-level categories. We examine the utility of this database and discuss ways in which it will support (i) exposure screening and prioritization, (ii) generic or framework formulations for several indoor/consumer product exposure modeling initiatives, (iii) candidate chemical selection for monitoring near field exposure from proximal sources, and (iv) as activity tracers or ubiquitous exposure sources using "chemical space" map analyses. Chemicals present at high concentrations and across multiple consumer products and use categories that hold high exposure potential are identified. Our database is publicly available to serve regulators, retailers, manufacturers, and the public for predictive screening of chemicals in new and existing consumer products on the basis of exposure and risk. Published by Elsevier Ltd. C1 [Goldsmith, M. -R.; Grulke, C. M.; Tan, Y. M.; Frame, A.; Egeghy, P. P.; Chang, D. T.; Tornero-Velez, R.; Isaacs, K.; Wang, A.; Johnson, J.; Holm, K.; Vallero, D. A.; Phillips, L.; Phillips, M.; Wambaugh, J. F.; Judson, R. S.; Buckley, T. J.; Dary, C. C.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Brooks, R. D.] US EPA, Res Triangle Pk, NC 27711 USA. [Transue, T. R.] Lockheed Martin Informat Technol, Res Triangle Pk, NC 27711 USA. [Edwards, R.] N Carolina State Univ, Raleigh, NC 27695 USA. [Frame, A.; Wang, A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Reich, M.] Univ N Carolina, Chapel Hill, NC 27514 USA. [Mitchell, J.] Michigan State Univ, E Lansing, MI 48824 USA. RP Goldsmith, MR (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM goldsmith.rocky@epa.gov; tan.cecilia@epa.gov; isaacs.kristin@epa.gov OI Phillips, Martin/0000-0002-6282-529X; Judson, Richard/0000-0002-2348-9633; Wambaugh, John/0000-0002-4024-534X FU United States Environmental Protection Agency through its Office of Research and Development; U.S. EPA Pathfinder Innovation Project award FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. The initial funding for this research came from a U.S. EPA Pathfinder Innovation Project award for "Systems Reality Modeling." We are grateful to the Shaw University Research Internship program for providing students that assisted in this research. We thank Charles Bevington and Cathy Fehrenbacher of the U.S. EPA's Office of Chemical Safety and Pollution Prevention for collaboration and helpful discussions. We thank Mike Uhl (Lockheed Martin Information Technology Services), Ravi Nair and Heidi Paulson (both U.S. EPA's Environmental Modeling and Visualization Laboratory) for project coordination on the interface design. We thank Pertti Hakkinen (National Library of Medicine) and Henry Delima (Henry Delima Associates) for providing input through ongoing discussion. We thank Linda Sheldon, Satori Marchitti and Haluk Ozkaynak (NERL) for administrative review and feedback. NR 41 TC 23 Z9 23 U1 4 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 EI 1873-6351 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD MAR PY 2014 VL 65 BP 269 EP 279 DI 10.1016/j.fct.2013.12.029 PG 11 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA AC4OL UT WOS:000332500500034 PM 24374094 ER PT J AU Li, GQ Field, MS AF Li, Guangquan Field, Malcolm S. TI A mathematical model for simulating spring discharge and estimating sinkhole porosity in a karst watershed SO GRUNDWASSER LA English DT Article DE Sinkhole porosity; Watershed balance; Karst aquifer; Turbulent flow; Analytical model ID CONDUIT FLOW; AQUIFERS; RESPONSES AB Documenting and understanding water balances in a karst watershed in which groundwater and surface water resources are strongly interconnected are important aspects for managing regional water resources. Assessing water balances in karst watersheds can be difficult, however, because karst watersheds are so very strongly affected by groundwater flows through solution conduits that are often connected to one or more sinkholes. In this paper we develop a mathematical model to approximate sinkhole porosity from discharge at a downstream spring. The model represents a combination of a traditional linear reservoir model with turbulent hydrodynamics in the solution conduit connecting the downstream spring with the upstream sinkhole, which allows for the simulation of spring discharges and estimation of sinkhole porosity. Noting that spring discharge is an integral of all aspects of water storage and flow, it is mainly dependent on the behavior of the karst aquifer as a whole and can be adequately simulated using the analytical model described in this paper. The model is advantageous in that it obviates the need for a sophisticated numerical model that is much more costly to calibrate and operate. The model is demonstrated using the St. Marks River Watershed in northwestern Florida. C1 [Li, Guangquan] Yunnan Univ, Dept Geophys, Kunming 650091, Yunnan, Peoples R China. [Field, Malcolm S.] US EPA, Natl Ctr Environm Assessment 8623P, Washington, DC 20460 USA. RP Field, MS (reprint author), US EPA, Natl Ctr Environm Assessment 8623P, 1200 Penn Ave NW, Washington, DC 20460 USA. EM guangquanli74@gmail.com; field.malcolm@epa.gov OI Field, Malcolm/0000-0002-8350-417X FU National Science Foundation of China [41162008] FX Funding support of this study was provided in part by the National Science Foundation of China under grant 41162008. Special gratitude to the Editor, Tobias Geyer, and two anonymous reviewers for their insightful comments and constructive suggestions. NR 28 TC 3 Z9 3 U1 1 U2 22 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1430-483X EI 1432-1165 J9 GRUNDWASSER JI Grundwasser PD MAR PY 2014 VL 19 IS 1 BP 51 EP 60 DI 10.1007/s00767-013-0243-3 PG 10 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AC8QM UT WOS:000332798700007 ER PT J AU Brown, RA Borst, M AF Brown, Robert A. Borst, Michael TI Evaluation of Surface Infiltration Testing Procedures in Permeable Pavement Systems SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Article DE Porous asphalt; Permeable pavement; Permeable interlocking concrete pavers; Pervious concrete; Infiltration; Storm water control measure; Green infrastructure; ASTM C1701 ID PERVIOUS CONCRETE; POROUS ASPHALT; STORM-WATER; ASTM C1701; PERFORMANCE; POLLUTION; QUALITY AB The ASTM method for measuring the infiltration rate of in-place pervious concrete provides limited guidance on how to select test locations and how results should be interpreted to assess surface condition and maintenance needs. The ASTM method is written specifically for pervious concrete, so additional research is needed to determine the applicability of this method to other permeable pavement types. In 2009, the U.S. Environmental Protection Agency constructed a 0.4-ha parking lot surfaced with permeable interlocking concrete pavers (PICP), pervious concrete (PC), and porous asphalt (PA). Surface infiltration testing was conducted for almost three years, and two methods were used to select test locations: monthly testing at randomly selected locations and quarterly testing at fixed locations. Infiltration rates were significantly different for each pavement type. With almost three years of use, maintenance has yet to be required, although infiltration has decreased in areas immediately downgradient of impermeable asphalt driving lanes and to a greater extent where disturbed soil was present. The longevity was attributed to the clogging mechanism. Runoff transports solids to the upgradient edge of the permeable pavement surface where the solids are filtered and accumulate as runoff infiltrates. As surface clogging progresses from the upgradient edge, the method of selecting a random location across the entire area typically resulted in most locations being on an unaffected area. This did not produce a meaningful change in infiltration rate to suggest maintenance was needed for the entire surface. The results of this study indicate that the ASTM C1701 method may be applicable to PICP; however, for PA, further evaluation is needed. It is recommended that future infiltration testing should strategically select fixed test locations based on expected clogging patterns. Furthermore, less water can be used, enabling more tests to be conducted at strategic locations over the pavement surface area to better determine locations of clogging. C1 [Brown, Robert A.] US EPA, ORISE, Edison, NJ 08837 USA. [Borst, Michael] US EPA, Edison, NJ 08837 USA. RP Brown, RA (reprint author), US EPA, ORISE, 2890 Woodbridge Ave,MS-104, Edison, NJ 08837 USA. EM brown.robert-a@epa.gov; borst.mike@epa.gov FU U.S. Department of Energy; U.S. Environmental Protection Agency FX This project was supported in part by an appointment to the Research Participation Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. The authors would like to thank PARS Environmental for conducting the infiltration measurements, and Mr. Thomas O'Connor, Dr. Amy Rowe, and Dr. Emilie Stander for their initial work in setting up the project. NR 37 TC 5 Z9 5 U1 2 U2 51 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD MAR 1 PY 2014 VL 140 IS 3 DI 10.1061/(ASCE)EE.1943-7870.0000808 PG 12 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AC6UF UT WOS:000332659800001 ER PT J AU Smith, E Scheckel, K Miller, BW Weber, J Juhasz, AL AF Smith, Euan Scheckel, Kirk Miller, Bradley W. Weber, John Juhasz, Albert L. TI Influence of in vitro assay pH and extractant composition on As bioaccessibility in contaminated soils SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Arsenic; Bioaccessibility; Speciation; XANES; Exposure ID DISSOLVED ORGANIC-CARBON; ARSENIC BIOACCESSIBILITY; RELATIVE BIOAVAILABILITY; OXIDE MINERALS; HEAVY-METALS; HUMAN HEALTH; SORPTION; IRON; SPECIATION; SPECTROSCOPY AB In vitro bioaccessibility assays are often utilised to determine the potential human exposure to soil contaminants through soil ingestion. Comparative studies have identified inconsistencies in the results obtained with different in vitro assays. In this study we investigated the potential causes for the variability between in vitro assay results using the PBET and SBRC assays to assess As bioaccessibility in 5 brownfield contaminated soils. Total As concentration in the 5 soils ranged from 227 to 807 mg As kg(-1) in the <250 mu m particle fraction while XANES analysis identified that As was predominately present as As-V (>88% was sorbed to Fe mineral phases) with the remaining As present as beudantite or orpiment mineral phases. Arsenic bioaccessibility varied depending on the in vitro methodology; markedly higher values were obtained using the SBRC gastric phase compared to the PBET gastric phase, however, similar As bioaccessibility values were obtained in both the SBRC and PBET intestinal phases. The difference in As bioaccessibility following SBRC and PBET gastric phase extraction appeared to be due to the difference in gastric phase pH (i.e. 1.5 versus 2.5 respectively), however, modifying the PBET gastric phase to pH 1.5 (that of the SBRC gastric phase) enhanced As bioaccessibility up to 1.6 fold, but was still markedly lower than SBRC values. Although As bioaccessibility was enhanced, the increase did not occur as a result of the solubilisation of As associated Fe mineral phases suggesting As bioaccessibility may also be strongly influenced by the in vitro assay extractant composition. The extractant composition of the PBET assay incorporates a number of organic acids in addition to pepsin which may inhibit the sorption of As onto iron oxide surfaces, therefore increasing As solubility at the modified (pH 1.5) gastric phase pH. (C) 2013 Elsevier B.V. All rights reserved. C1 [Smith, Euan; Weber, John; Juhasz, Albert L.] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. [Smith, Euan; Juhasz, Albert L.] Cooperat Res Ctr Contaminat Assessment & Remediat, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA. [Miller, Bradley W.] US EPA, Natl Enforcement Invest Ctr, Denver, CO 80225 USA. RP Smith, E (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. EM Euan.Smith@unisa.edu.au RI Juhasz, Albert/F-6600-2011; BM, MRCAT/G-7576-2011; ID, MRCAT/G-7586-2011; OI Juhasz, Albert/0000-0002-1164-4085; Scheckel, Kirk/0000-0001-9326-9241 FU EPA FX Although EPA staff contributed to this article, the research presented was not performed by, or funded by, the EPA and was not subject to the EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not reflect or represent the EPA's views or policies. NR 56 TC 16 Z9 16 U1 5 U2 61 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD MAR 1 PY 2014 VL 473 BP 171 EP 177 DI 10.1016/j.scitotenv.2013.12.030 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AB6UB UT WOS:000331923900022 PM 24369295 ER PT J AU Ryu, H Grond, K Verheijen, B Elk, M Buehler, DM Domingo, JWS AF Ryu, Hodon Grond, Kirsten Verheijen, Bram Elk, Michael Buehler, Deborah M. Domingo, Jorge W. Santo TI Intestinal Microbiota and Species Diversity of Campylobacter and Helicobacter spp. in Migrating Shorebirds in Delaware Bay SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID RIBOSOMAL-RNA GENES; WEST NILE VIRUS; REAL-TIME PCR; MOLECULAR-DETECTION; QUANTITATIVE PCR; GRUS-CANADENSIS; FECAL SAMPLES; WILD BIRDS; GULL FECES; BACTERIA AB Using 16S rRNA gene sequencing analysis, we examined the bacterial diversity and the presence of opportunistic bacterial pathogens (i.e., Campylobacter and Helicobacter) in red knot (Calidris canutus; n = 40), ruddy turnstone (Arenaria interpres; n = 35), and semipalmated sandpiper (Calidris pusilla; n = 22) fecal samples collected during a migratory stopover in Delaware Bay. Additionally, we studied the occurrence of Campylobacter spp., enterococci, and waterfowl fecal source markers using quantitative PCR (qPCR) assays. Of 3,889 16S rRNA clone sequences analyzed, the bacterial community was mostly composed of Bacilli (63.5%), Fusobacteria (12.7%), Epsilonproteobacteria (6.5%), and Clostridia (5.8%). When epsilonproteobacterium-specific 23S rRNA gene clone libraries (i.e., 1,414 sequences) were analyzed, the sequences were identified as Campylobacter (82.3%) or Helicobacter (17.7%) spp. Specifically, 38.4%, 10.1%, and 26.0% of clone sequences were identified as C. lari (>99% sequence identity) in ruddy turnstone, red knot, and semipalmated sandpiper clone libraries, respectively. Other pathogenic species of Campylobacter, such as C. jejuni and C. coli, were not detected in excreta of any of the three bird species. Most Helicobacter-like sequences identified were closely related to H. pametensis (>99% sequence identity) and H. anseris (92% sequence identity). qPCR results showed that the occurrence and abundance of Campylobacter spp. was relatively high compared to those of fecal indicator bacteria, such as Enterococcus spp., E. faecalis, and Catellicoccus marimammalium. Overall, the results provide insights into the complexity of the shorebird gut microbial community and suggest that these migratory birds are important reservoirs of pathogenic Campylobacter species. C1 [Ryu, Hodon; Elk, Michael; Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Grond, Kirsten; Buehler, Deborah M.] Royal Ontario Museum, Dept Nat Hist, Toronto, ON M5S 2C6, Canada. [Grond, Kirsten; Buehler, Deborah M.] Univ Toronto, Toronto, ON, Canada. [Grond, Kirsten; Verheijen, Bram] Kansas State Univ, Manhattan, KS 66506 USA. RP Domingo, JWS (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM santodomingo.jorge@epa.gov FU Natural Science and Engineering Council of Canada [PDF-373488-2009]; Netherlands Organization for Scientific Research; U.S. Environmental Protection Agency through Office of Research and Development FX This study was funded by grants from the Natural Science and Engineering Council of Canada (PDF-373488-2009) and the Netherlands Organization for Scientific Research (Rubicon 825.09.0190) to D. M. B. and by the U.S. Environmental Protection Agency through its Office of Research and Development. NR 42 TC 10 Z9 10 U1 5 U2 36 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2014 VL 80 IS 6 BP 1838 EP 1847 DI 10.1128/AEM.03793-13 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AB8FO UT WOS:000332025800004 PM 24413599 ER PT J AU Hazari, MS Griggs, J Winsett, DW Haykal-Coates, N Ledbetter, A Costa, DL Farraj, AK AF Hazari, Mehdi S. Griggs, Jennifer Winsett, Darrell W. Haykal-Coates, Najwa Ledbetter, Allen Costa, Daniel L. Farraj, Aimen K. TI A Single Exposure to Acrolein Desensitizes Baroreflex Responsiveness and Increases Cardiac Arrhythmias in Normotensive and Hypertensive Rats SO CARDIOVASCULAR TOXICOLOGY LA English DT Article DE Acrolein; Baroreflex; Spontaneously hypertensive; Arrhythmia; Electrocardiogram ID HEART-RATE-VARIABILITY; SMOKE EXPOSURE; TOBACCO-SMOKE; AIR-POLLUTION; SENSITIVITY; DISEASE; INHALATION; REFLEX; RISK; FIREFIGHTERS AB Short-term exposure to air pollutants has been linked to acute cardiovascular morbidity and mortality. Even in the absence of overt signs or symptoms, pollutants can cause subtle disruptions to internal compensatory mechanisms, which maintain homeostatic balance in response to various environmental and physiological stressors. We hypothesized that a single exposure to acrolein, a ubiquitous gaseous air pollutant, would decrease the sensitivity of baroreflex (BRS), which maintains blood pressure by altering heart rate (HR), modify cardiac electrophysiological properties and increase arrhythmia in rats. Wistar-Kyoto normotensive (WKY) and spontaneously hypertensive (SH) rats implanted with radiotelemeters and a chronic jugular vein catheter were tested for BRS using phenylephrine and sodium nitroprusside 2 days before and 1 h after whole-body exposure to 3 ppm acrolein (3 h). HR and electrocardiogram (ECG) were continuously monitored for the detection of arrhythmia in the pre-exposure, exposure and post-exposure periods. Whole-body plethysmography was used to continuously monitor ventilation in conscious animals. SH rats had higher blood pressure, lower BRS and increased frequency of AV block as evidence by non-conducted p-waves when compared with WKY rats. A single exposure to acrolein caused a decrease in BRS and increased incidence of arrhythmia in both WKY and SH rats. There were minimal ECG differences between the strains, whereas only SH rats experienced irregular breathing during acrolein. These results demonstrate that acrolein causes immediate cardiovascular reflexive dysfunction and persistent arrhythmia in both normal and hypertensive animals. As such, homeostatic imbalance may be one mechanism by which air pollution increases risk 24 h after exposure, particularly in people with underlying cardiovascular disease. C1 [Hazari, Mehdi S.; Winsett, Darrell W.; Ledbetter, Allen; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Griggs, Jennifer] Univ N Carolina, Chapel Hill, NC 27599 USA. [Haykal-Coates, Najwa; Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Hazari, MS (reprint author), US EPA, Environm Publ Hlth Div, 109 Alexander Dr,B105, Res Triangle Pk, NC 27711 USA. EM hazari.mehdi@epa.gov OI Griggs, Jennifer/0000-0002-9587-5621 NR 56 TC 7 Z9 7 U1 0 U2 6 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1530-7905 EI 1559-0259 J9 CARDIOVASC TOXICOL JI Cardiovasc. Toxicol. PD MAR PY 2014 VL 14 IS 1 BP 52 EP 63 DI 10.1007/s12012-013-9228-9 PG 12 WC Cardiac & Cardiovascular Systems; Toxicology SC Cardiovascular System & Cardiology; Toxicology GA AB9JN UT WOS:000332109000006 PM 24078368 ER PT J AU Janousek, CN Folger, CL AF Janousek, Christopher N. Folger, Christina L. TI Variation in tidal wetland plant diversity and composition within and among coastal estuaries: assessing the relative importance of environmental gradients SO JOURNAL OF VEGETATION SCIENCE LA English DT Article DE NMDS; Species accumulation curves; Hierarchical partitioning; Soil salinity; Tidal swamp; Path analysis; Salt marsh; Tidal elevation ID SALT-MARSH; SPECIES RICHNESS; CLIMATE-CHANGE; FRESH-WATER; VEGETATION; SALINITY; PATTERNS; HALOPHYTES; ELEVATION; ZONATION AB Questions What is the relative importance of topographic (elevation), edaphic (soil salinity, nitrogen and particle size) and hydrologic (estuarine river flow) gradients for variation in tidal wetland plant composition and diversity? Location Four Oregon estuaries: a marine-dominated lagoon, two tidal-driven bays, and a river-dominated site. Methods We surveyed species presence, cover and richness; and environmental factors (soil salinity, grain size, soil nitrogen and elevation) in plots in marsh and swamp. We assessed patterns of community structure and the relative importance of environmental gradients with hierarchical partitioning, ordination, species accumulation curves and path analysis. Results The relative importance of measured environmental gradients on plant occurrence differed by species. Soil salinity or elevation explained the most variation in the majority of common species. Estuarine hydrology, soil nitrogen and soil clay content were usually of secondary or minor importance. Assemblage composition and species richness varied most strongly with tidal elevation. Local soil salinity also affected composition, but differences in estuarine hydrology had comparatively less effect on composition and richness. Higher-elevation wetlands supported larger species pools and higher plot-level richness; fresher wetlands had larger species pools than salt marsh but plot-level richness was relatively invariant to differences in soil salinity. Conclusions Elevation and salinity tended to exert more influence on the vegetation structure of tidal wetlands than estuarine hydrology or other edaphic variables. With relative sea-level rise expected to increase both flooding intensity and salinity exposure in future wetlands, global climate change may lead to changes in species distributions, altered floristic composition and reduced plant species richness. C1 [Janousek, Christopher N.; Folger, Christina L.] US EPA, Western Ecol Div, Off Res & Dev, Newport, OR 97365 USA. RP Janousek, CN (reprint author), US EPA, Western Ecol Div, Off Res & Dev, 2111 SE Marine Sci Dr, Newport, OR 97365 USA. EM cnjanousek@gmail.com; Folger.Christina@epa.gov FU U.S. Environmental Protection Agency FX We thank D. Beugli, H. Brunner, V. Goldsmith, J. Saarinen, K. Marko, J. Stecher, T. Ernst, M. Frazier, L. Brophy, R. Loiselle, T. MochonCollura, S. Cline and M. Armstrong for various lab, field, technical and statistical assistance. P. Clinton kindly provided GIS support. B. Watson, M. Frazier, R. Halvorsen and two anonymous reviewers made helpful comments on the manuscript. Sampling was made possible by the cooperation of numerous landholders including the US Fish and Wildlife Service (Bandon NWR), BLM, US Forest Service, Oregon State Parks, Oregon State University, Port of Toledo, Port of Bandon, The Wetlands Conservancy, van Eck Foundation and other private owners. The information in this publication has been funded by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Lab and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 45 TC 7 Z9 7 U1 4 U2 93 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1100-9233 EI 1654-1103 J9 J VEG SCI JI J. Veg. Sci. PD MAR PY 2014 VL 25 IS 2 BP 534 EP 545 DI 10.1111/jvs.12107 PG 12 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA AB3LW UT WOS:000331693300021 ER PT J AU Shanks, OC Kelty, CA Peed, L Sivaganesan, M Mooney, T Jenkins, M AF Shanks, Orin C. Kelty, Catherine A. Peed, Lindsay Sivaganesan, Mano Mooney, Thomas Jenkins, Michael TI Age-Related Shifts in the Density and Distribution of Genetic Marker Water Quality Indicators in Cow and Calf Feces SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID REAL-TIME PCR; ESCHERICHIA-COLI O157-H7; BOVINE FECAL POLLUTION; 16S RIBOSOMAL-RNA; QUANTITATIVE PCR; BACTERIA; MONENSIN; SAMPLES; ASSAYS; RUMEN AB Calves make up about 16% of the current bovine population in the United States and can excrete high levels of human pathogens in their feces. We describe the density and distribution of genetic markers from 9 PCR- and real-time quantitative PCR-based assays, including CF128, CF193, CowM2, CowM3, GenBac3, Entero1, EC23S857, CampF2, and ttr-6, commonly used to help assess ambient surface water quality. Each assay was tested against a collection of 381 individual bovine fecal samples representing 31 mother and calf pairings collected over a 10-month time period from time of birth through weaning. Genetic markers reported to be associated with ruminant and/or bovine fecal pollution were virtually undetected in calves for up to 115 days from birth, suggesting that physiological changes in calf ruminant function impact host-associated genetic marker shedding. In addition, general fecal indicator markers for Bacteroidales, Escherichia coli, and Enterococcus spp. exhibited three separate trends across time, indicating that these bacteria respond differently to age-related physiological and dietary changes during calf development. The results of this study suggest that currently available PCR-based water quality indicator technologies can under-or overestimate fecal pollution originating from calves and identify a need for novel calf-associated source identification methods. C1 [Shanks, Orin C.; Kelty, Catherine A.; Peed, Lindsay; Sivaganesan, Mano] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Mooney, Thomas] Univ Cincinnati, Cincinnati, OH USA. [Jenkins, Michael] ARS, USDA, Natl Sedimentat Lab, Water Qual & Ecol Res Unit, Oxford, MS USA. RP Shanks, OC (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM shanks.orin@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described here. It has been subjected to the Agency's peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the official positions and policies of the U.S. EPA. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 33 TC 2 Z9 3 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2014 VL 80 IS 5 BP 1588 EP 1594 DI 10.1128/AEM.03581-13 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AB2MH UT WOS:000331626300006 PM 24362434 ER PT J AU Liu, XY Guo, ZS Krebs, KA Pope, RH Roache, NF AF Liu, Xiaoyu Guo, Zhishi Krebs, Kenneth A. Pope, Robert H. Roache, Nancy F. TI Concentrations and trends of perfluorinated chemicals in potential indoor sources from 2007 through 2011 in the US SO CHEMOSPHERE LA English DT Article DE Perfluorinated chemicals; Perfluorooctanoic acid; Perfluorocarboxylic acids; Perfluoroalkyl sulfonates; Indoor microenvironments; Indoor sources ID DUST; HOMES; PFOA AB Certain perfluorinated chemicals (PFCs) in consumer products used indoors are potential indoor PFCs sources and have been associated with developmental toxicity and other adverse health effects in laboratory animals (Lao et al., 2007). The concentrations of selected PFCs including perfluorooctanoic acid (PFOA) and other perfluorocarboxylic acids (PFCAs), in 35 selected consumer products that are commonly used in indoors were measured from the year of 2007 through 2011. The products collected included carpet, commercial carpet-care liquids, household carpet/fabric-care liquids, treated apparel, treated home textiles, treated non-woven medical garments, floor waxes, food-contact paper, membranes for apparel, and thread-sealant tapes. They were purchased from retail outlets in the United States between March 2007 and September 2011. The perfluorocarboxylic acid (PFCA) contents in the products have shown an overall downward trend. However, PFOA (C8) could still be detected in many products that we analyzed. Reductions of PFCAs were shown in both short-chain PFCAs (sum of C4 to C7) and long-chain PFCAs (sum of C8 to C12) over the study period. There were no significant changes observed between short-chain PFCAs and long-chain PFCAs. Fourteen products were analyzed to determine the amounts of perfluoroalkyl sulfonates (PFASs) they contained. These limited data show the pronounced increase of perfluoro-butane sulfonate (PFBS), an alternative to perfluorooctanoic sulfonate (PFOS), in the samples. A longer and wider range of study will be required to confirm this observed trend. Published by Elsevier Ltd. C1 [Liu, Xiaoyu; Guo, Zhishi; Krebs, Kenneth A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Pope, Robert H.; Roache, Nancy F.] Arcadis US Inc, Durham, NC 27713 USA. RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM liu.xiaoyu@epa.gov NR 20 TC 12 Z9 12 U1 5 U2 57 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2014 VL 98 BP 51 EP 57 DI 10.1016/j.chemosphere.2013.10.001 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AB3GP UT WOS:000331679600006 PM 24268172 ER PT J AU Gabriel, M Howard, N Osborne, T AF Gabriel, Mark C. Howard, Nicole Osborne, Todd Z. TI Fish Mercury and Surface Water Sulfate Relationships in the Everglades Protection Area SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Mercury; Sulfate; Everglades; Bioaccumulation; CERP; Fish ID DISSOLVED ORGANIC-MATTER; DESULFOVIBRIO-DESULFURICANS ND132; SEDIMENT PORE WATERS; FLORIDA EVERGLADES; METHYLMERCURY PRODUCTION; METHYLATING BACTERIA; ESCHERICHIA-COLI; SULFIDE; SULFUR; WETLAND AB Few published studies present data on relationships between fish mercury and surface or pore water sulfate concentrations, particularly on an ecosystem-wide basis. Resource managers can use these relationships to identify the sulfate conditions that contain fish with health-concerning total mercury (THg) levels and to evaluate the role of sulfate in methyl-mercury (MeHg) production. In this study, we derived relationships between THg in three fish trophic levels (mosquitofish, sunfish, and age-1 largemouth bass) and surface water sulfate from 1998 to 2009 for multiple stations across the Everglades Protection Area (EPA). Results show the relationship between sulfate and fish THg in each fish type is nonlinear and largely skewed, similar to the relationship between MeHg production and sulfate concentration in peatland sediment pore water identified by other researchers. Peak fish THg levels occurred in similar to 1 to 12 mg/L sulfate conditions. There was significant variability in the fish THg data, and there were several instances of high-fish THg levels in high-sulfate conditions (> 30 mg/L). Health-concerning fish THg levels were present in all surface water sulfate conditions; however, most of these levels occurred in 1-20 mg/L sulfate. The data in this study, including recent studies, show consistent and identifiable areas of high- and low-fish THg across the spectrum of surface water sulfate concentration, therefore, applying an ecosystem-wide sulfur strategy may be an effective management approach as it would significantly reduce MeHg risk in the EPA. C1 [Gabriel, Mark C.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. [Howard, Nicole; Osborne, Todd Z.] Univ Florida, Soil & Water Sci Dept, Wetland Biogeochem Lab, Gainesville, FL 32611 USA. [Osborne, Todd Z.] Whitney Lab Marine Biosci, St Augustine, FL USA. RP Gabriel, M (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA. EM marklive02@yahoo.com FU University of Florida FX The authors thank the South Florida Water Management District for providing the data used in this study and the anonymous reviewers for their helpful comments and suggestions. This article has been reviewed in accordance with the U.S. Environmental Protection Agency's peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. The authors received financial support from the University of Florida to publish this manuscript. NR 66 TC 14 Z9 14 U1 3 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD MAR PY 2014 VL 53 IS 3 BP 583 EP 593 DI 10.1007/s00267-013-0224-4 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA AB7FX UT WOS:000331956000008 PM 24385066 ER PT J AU Golden, HE Lane, CR Amatya, DM Bandilla, KW Kiperwas, HR Knightes, CD Ssegane, H AF Golden, Heather E. Lane, Charles R. Amatya, Devendra M. Bandilla, Karl W. Kiperwas, Hadas Raanan Knightes, Christopher D. Ssegane, Herbert TI Hydrologic connectivity between geographically isolated wetlands and surface water systems: A review of select modeling methods SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Review DE Geographically isolated wetlands; Hydrologic connectivity; Watershed approach; Surface waters; Mechanistic models ID GROUNDWATER-FLOW MODEL; LOWLAND WET GRASSLAND; SENEGAL RIVER-BASIN; ANALYTIC ELEMENT; SOUTH-CAROLINA; COASTAL-PLAIN; CLIMATE-CHANGE; LAND-USE; BIOGEOCHEMICAL PROCESSES; DEPRESSIONAL WETLANDS AB Geographically isolated wetlands (GIW), depressional landscape features entirely surrounded by upland areas, provide a wide range of ecological functions and ecosystem services for human well-being. Current and future ecosystem management and decision-making rely on a solid scientific understanding of how hydrologic processes affect these important GIW services and functions, and in turn on how GIWs affect downstream surface water systems. Consequently, quantifying the hydrologic connectivity of GIWs to other surface water systems (including streams, rivers, lakes, and other navigable waters) and the processes governing hydrologic connectivity of GIWs at a variety of watershed scales has become an important topic for the scientific and decision-making communities. We review examples of potential mechanistic modeling tools that could be applied to further advance scientific understanding concerning: (1) The extent to which hydrologic connections between GIWs and other surface waters exist, and (2) How these connections affect downstream hydrology at the scale of watersheds. Different modeling approaches involve a variety of domain and process conceptualizations, and numerical approximations for GIW-related questions. We describe select models that require only limited modifications to model the interaction of GIWs and other surface waters. We suggest that coupled surface subsurface approaches exhibit the most promise for characterizing GIW connectivity under a variety of flow conditions, though we note their complexity and the high level of modeling expertise required to produce reasonable results. We also highlight empirical techniques that will inform mechanistic models that estimate hydrologic connectivity of GIWs for research, policy, and management purposes. Developments in the related disciplines of remote sensing, hillslope and wetland hydrology, empirical modeling, and tracer studies will assist in advancing current mechanistic modeling approaches to most accurately elucidate connectivity of GIWs to other surface waters and the effects of GIWs on downstream systems at the watershed scale. Published by Elsevier Ltd. C1 [Golden, Heather E.; Lane, Charles R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Amatya, Devendra M.; Ssegane, Herbert] US Forest Serv, USDA, Southern Res Stn, Cordesville, SC USA. [Bandilla, Karl W.] Princeton Univ, Dept Civil & Environm Engn, Princeton, NJ 08544 USA. [Kiperwas, Hadas Raanan] US EPA, Off Wetlands Oceans & Watersheds, Washington, DC 20460 USA. [Knightes, Christopher D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA USA. RP Golden, HE (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, 26 W Martin Luther King Dr,MS 585, Cincinnati, OH 45268 USA. EM golden.heather@epa.gov RI Ssegane, Herbert/K-8098-2014 NR 175 TC 23 Z9 24 U1 12 U2 119 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD MAR PY 2014 VL 53 BP 190 EP 206 DI 10.1016/j.envsoft.2013.12.004 PG 17 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA AB3KA UT WOS:000331688500017 ER PT J AU Buse, HY Lu, JR Struewing, IT Ashbolt, NJ AF Buse, Helen Y. Lu, Jingrang Struewing, Ian T. Ashbolt, Nicholas J. TI Preferential colonization and release of Legionella pneumophila from mature drinking water biofilms grown on copper versus unplasticized polyvinylchloride coupons SO INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH LA English DT Article DE CDC biofilm reactor; Copper; uPVC; Drinking water; HPC; ATP ID POTABLE-WATER; LEGIONNAIRES-DISEASE; SYSTEM; SURVIVAL; AMEBAS; MULTIPLICATION; CONTAMINATION; PERSISTENCE; CELLS AB Legionella occurrence in premise drinking water (DW) systems contributes to legionellosis outbreaks, especially in the presence of suitable protozoan hosts. This study examined L. pneumophila behavior within DW biofilms grown on copper (Cu) and unplasticized polyvinylchloride (uPVC) surfaces in the presence of Acanthamoeba polyphaga. One year-old DW biofilms were established within six CDC biofilm reactors: three each containing Cu or uPVC coupons. Biofilms were then inoculated with L. pneumophila (uPVC-Lp and Cu-Lp), or L. pneumophila and A. polyphaga (uPVC-Lp/Ap and Cu-Lp/Ap) and compared to sterile water inoculated controls (uPVC- and Cu-Control) over a 4 month period. L. pneumophila appeared more persistent by qPCR within Cu biofilms in the presence of A. polyphaga compared to uPVC biofilms with or without A. polyphaga, but maintained their cultivability in uPVC biofilms compared to Cu biofilms. Also, persistent shedding of L. pneumophila cells (assayed by qPCR) in the effluent water implied colonization of L. pneumophila within Cu-coupon reactors compared to no detection from uPVC-coupon reactor effluent 14 days after inoculation. Hence, L. pneumophila appeared to colonize Cu surfaces more effectively and may be shed from the biofilms at a greater frequency and duration compared to L. pneumophila colonized uPVC surfaces with host amoebae playing a role in L. pneumophila persistence within Cu biofilms. Published by Elsevier GmbH. C1 [Buse, Helen Y.; Struewing, Ian T.] Dynamac Corp, US EPA, Cincinnati, OH USA. [Lu, Jingrang; Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH USA. RP Buse, HY (reprint author), 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM buse.helen@epa.gov NR 31 TC 9 Z9 9 U1 1 U2 16 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1438-4639 EI 1618-131X J9 INT J HYG ENVIR HEAL JI Int. J. Hyg. Environ. Health. PD MAR PY 2014 VL 217 IS 2-3 BP 219 EP 225 DI 10.1016/j.ijheh.2013.04.005 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AB2AN UT WOS:000331595500011 PM 23706882 ER PT J AU Sarwar, G Simon, H Fahey, K Mathur, R Goliff, WS Stockwell, WR AF Sarwar, Golam Simon, Heather Fahey, Kathleen Mathur, Rohit Goliff, Wendy S. Stockwell, William R. TI Impact of sulfur dioxide oxidation by Stabilized Criegee Intermediate on sulfate SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Stabilized Criegee Intermediate; Alkene; Ozone; Sulfur dioxide; Sulfate; Water; Oxidation ID VOLATILE ORGANIC-COMPOUNDS; CMAQ MODELING SYSTEM; GAS-PHASE; TROPOSPHERIC DEGRADATION; ATMOSPHERIC SULFATE; UNITED-STATES; WATER DIMER; MECHANISM; SO2; REACTIVITY AB We revise the Carbon Bond chemical mechanism to explicitly represent three Stabilized Criegee Intermediates (SCIs) and their subsequent reactions with sulfur dioxide, water monomer, and water dimer, and incorporate the reactions into the Community Multiscale Air Quality model. The reaction of sulfur dioxide with SCI produces sulfuric acid which partitions into sulfate. We examine the impact of sulfur dioxide oxidation by SCI on sulfate using two different measured rate constants for the reaction of sulfur dioxide and SCI. When we use the higher rate constant and emissions estimates from the Biogenic Emissions Inventory System, it enhances monthly mean sulfate in summer by similar to 20% in biogenically active areas. Enhancements are driven primarily by SCI produced from the reactions of biogenically derived alkenes and ozone. The use of the lower rate constant only marginally enhances sulfate since it is 65 times lower than the higher rate constant. We performed several sensitivity analyses to investigate the impacts of uncertain biogenic emissions and SCI loss rates. When we use the higher rate constant and emissions estimates from the Model of Emissions of Gases and Aerosols from Nature, it enhances monthly mean sulfate by similar to 75%. A simulation using the lowest reported rate constant for the reaction of SCI and water indicated the maximum enhancement of sulfate from this chemistry was up to 4 mu g/m(3) over a 24-h period in some locations in the Southeastern U.S. Predictions without the SCI reaction are lower than observed sulfate while predictions with the SCI reaction improve the agreements with observations. Published by Elsevier Ltd. C1 [Sarwar, Golam; Fahey, Kathleen; Mathur, Rohit] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. [Simon, Heather] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Goliff, Wendy S.] Univ Calif Riverside, Ctr Environm Res & Technol, Coll Engn, Riverside, CA 92507 USA. [Stockwell, William R.] Howard Univ, Dept Chem, Washington, DC 20059 USA. RP Sarwar, G (reprint author), US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM sarwar.golam@epa.gov RI simon, heather/E-4392-2011; OI simon, heather/0000-0001-7254-3360; Stockwell, William/0000-0002-7509-6575 NR 45 TC 16 Z9 16 U1 3 U2 71 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD MAR PY 2014 VL 85 BP 204 EP 214 DI 10.1016/j.atmosenv.2013.12.013 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AA9MN UT WOS:000331417700023 ER PT J AU Slob, W Setzer, RW AF Slob, Wout Setzer, R. Woodrow TI Shape and steepness of toxicological dose-response relationships of continuous endpoints SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE BMD; dose-response shape; historical data; linearity; model uncertainty; parameter constraints; sublinearity; threshold ID LYMPH-NODE ASSAY; DEVELOPMENTAL TOXICITY; IN-VITRO; N-NITROSODIMETHYLAMINE; CHRONIC INGESTION; RISK-ESTIMATION; RATS; NITROSODIETHYLAMINE; CHEMICALS; POTENCY AB A re-analysis of a large number of historical dose-response data for continuous endpoints indicates that an exponential or a Hill model with four parameters adequately describes toxicological dose-responses. No exceptions were found for the datasets considered, which related to a wide variety of endpoints and to both in vivo and in vitro studies of various types. For a given endpoint/study type dose-response shapes were found to be homogenous among chemicals in the in vitro studies considered, while a mild among-chemical variation in the steepness parameter seemed to be present in the in vivo studies. Our findings have various practical consequences. For continuous endpoints, model selection in the BMD approach is not a crucial issue. The often applied approach of using constraints on the model parameters to prevent "infinite" slopes at dose zero in fitting a model is not in line with our findings, and appears to be unjustified. Instead, more realistic ranges of parameter values could be derived from re-analyses of large numbers of historical dose-response datasets in the same endpoint and study type, which could be used as parameter constraints in future individual datasets. This approach will be particularly useful for weak datasets (e.g. few doses, much scatter). In addition, this approach may open the way to use fewer animals in future studies. In the discussion, we argue that distinctions between linear, sub/supralinear or thresholded dose-response shapes, based on visual inspection of plots, are not biologically meaningful nor useful for risk assessment. C1 [Slob, Wout] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Setzer, R. Woodrow] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Slob, W (reprint author), Natl Inst Publ Hlth & Environm, POB 1, NL-3720 BA Bilthoven, Netherlands. EM wout.slob@rivm.nl FU Netherlands Food and Consumer Product Safety Authority (NVWA) FX The authors' affiliations are as shown on the cover page. The authors have sole responsibility for the writing and content of the paper. The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA). NR 27 TC 27 Z9 27 U1 2 U2 17 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD MAR PY 2014 VL 44 IS 3 BP 270 EP 297 DI 10.3109/10408444.2013.853726 PG 28 WC Toxicology SC Toxicology GA AB5SF UT WOS:000331848100003 PM 24252121 ER PT J AU Awkerman, JA Raimondo, S Jackson, CR Barron, MG AF Awkerman, Jill A. Raimondo, Sandy Jackson, Crystal R. Barron, Mace G. TI Augmenting aquatic species sensitivity distributions with interspecies toxicity estimation models SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Aquatic toxicology; Species sensitivity distributions; Species extrapolation; Risk assessment ID RISK-ASSESSMENT; WILDLIFE AB Species sensitivity distributions (SSDs) are cumulative distribution functions of species toxicity values. The SSD approach is being used increasingly in ecological risk assessment but is often limited by available toxicity data needed for diverse species representation. In the present study, the authors evaluate augmenting aquatic species databases limited to standard test species using toxicity values extrapolated from interspecies correlation estimation (ICE) models for SSD development. The authors compared hazard concentrations at the 5th centile (HC5) of SSDs developed using limited measured data augmented with ICE toxicity values (augmented SSDs) with those estimated using larger measured toxicity datasets of diverse species (reference SSDs). When SSDs had similar species composition to the reference SSDs, 0.76 of the HC5 estimates were closer to the reference HC5; however, the proportion of augmented HC5s that were within 5-fold of the reference HC5s was 0.94, compared with 0.96 when predicted SSDs had random species assemblages. The range of toxicity values among represented species in all SSDs also depended on a chemical's mode of action. Predicted HC5 estimations for acetylcholinesterase inhibitors showed the greatest discrepancies from the reference HC5 when SSDs were limited to commonly tested species. The results of the present study indicate that ICE models used to augment datasets for SSDs do not greatly affect HC5 uncertainty. Uncertainty analysis of risk assessments using SSD hazard concentrations should address species composition, especially for chemicals with known taxa-specific differences in toxicological effects. Environ Toxicol Chem 2014;33:688-695. (c) 2013 SETAC. This article is a US Government work and is in the public domain in the USA. C1 [Awkerman, Jill A.; Raimondo, Sandy; Jackson, Crystal R.; Barron, Mace G.] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. RP Awkerman, JA (reprint author), US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. EM Awkerman.Jill@epa.gov FU USEPA, National Health and Environmental Effects Research Laboratory FX For database development and maintenance, we thank B. Montague (US Environmental Protection Agency [USEPA], Office of Pesticide Programs) and P. Mineau, A. Baril, and B. Collins (Environment Canada). We are also grateful to support personnel: D. Vivian, M. Marchetto, A. DiGirolamo, C. Chancy, N. Lemoine, N. Allard, and C. McGill (USEPA, Gulf Ecology Division). Two anonymous reviewers provided helpful guidance to an earlier draft. Support in preparing this manuscript was provided by the USEPA, National Health and Environmental Effects Research Laboratory. Although this manuscript was submitted for internal review within USEPA and approved for publication, it does not reflect the views of the agency or constitute an endorsement of any trade names or commercial products mentioned. NR 23 TC 6 Z9 8 U1 4 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2014 VL 33 IS 3 BP 688 EP 695 DI 10.1002/etc.2456 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AA8HA UT WOS:000331335000028 PM 24214839 ER PT J AU Field, LJ Norton, SB AF Field, L. Jay Norton, Susan B. TI Regional models for sediment toxicity assessment SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Toxicity; Sediment; Logistic regression models ID QUALITY GUIDELINE QUOTIENTS; GRAND-CALUMET RIVER; CONTAMINATION; ECOSYSTEMS; AGREEMENT; CHEMISTRY; INDIANA; FLORIDA; MARINE; USA AB The present study describes approaches to improve the performance of empirical models developed from a large nationwide data set to predict sediment toxicity from chemistry for regional applications. The authors developed 4 multiple chemical (P-Max) models selected from individual chemical models developed using 1) a previously published approach applied to the nationwide data set; 2) a broader array of response and explanatory variables (e.g., different normalization approaches and toxicity classifications) applied to the nationwide data set; 3) a data set from the New York/New Jersey, USA, region; and 4) both nationwide and regional data sets. The models were calibrated using the regional data set. Performance was tested using an independent data set from the same region. The performance of the final P-Max model developed using the calibration process substantially improved over that of the uncalibrated P-Max model developed using the nationwide data set. The improvements were achieved by selecting the best performing individual chemical models and eliminating those that performed poorly when applied together. Although the best performing P-Max model included both nationwide and region-specific models, the performance of the P-Max model derived using only nationwide models was nearly as good. These results suggest that calibrating nationwide models to a regional data set may be both a more efficient and effective approach for improving model performance than developing region-specific models. Environ Toxicol Chem 2014;33:708-717. (c) 2013 SETAC. This article is a US Government work and is in the public domain in the USA. C1 [Field, L. Jay] NOAA, Off Response & Restorat, Seattle, WA USA. [Norton, Susan B.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Field, LJ (reprint author), NOAA, Off Response & Restorat, Seattle, WA USA. EM jay.field@noaa.gov FU [DW-13-92192901-2] FX B. Shepard, S. Bay, K. Ritter, R. Smith (deceased), D. Farrar, P. Myre, C. Ingersoll, K. Finkelstein, and 2 anonymous reviewers. We gratefully acknowledge the many scientists who collect sediment toxicity and chemistry data. This work was supported by Interagency Agreement DW-13-92192901-2. NR 33 TC 1 Z9 1 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2014 VL 33 IS 3 BP 708 EP 717 DI 10.1002/etc.2485 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AA8HA UT WOS:000331335000031 PM 24306981 ER PT J AU Liu, XL Murdoch, LC Falta, RW Tan, TW AF Liu, Xiaoling Murdoch, Lawrence C. Falta, Ronald W. Tan, Tianwu TI Experimental characterization of CVOC removal from fractured clay during boiling SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE CVOC; Clay; Boiling; Fractures; Thermal remediation ID CHLORINATED SOLVENTS; CONTAMINANT REMOVAL; BUBBLE-GROWTH; EXTRACTION; SEDIMENTS; ROCK; TRICHLOROETHYLENE; REMEDIATION; SOIL AB A series of experiments was conducted to evaluate the mass transport of a chlorinated volatile organic compound (CVOC) at boiling temperatures in low permeability clays where 20-100% of the pore water was removed. A kaolin clay matrix saturated with water containing 1,2-dichloroethane (DCA) and bromide (Br-) was packed into two columnar cells, a rigid-wall and a flexible-wall tube, which created different external boundary conditions. Both cells were heated to boiling temperatures and the recovered outflow was condensed and analyzed for DCA and bromide, and the clay remaining in the cell was cooled and analyzed for water and DCA content. Clay in the vertically oriented rigid-wall cell was heated to 130 degrees C with a power density of similar to 80 kW/m(3) and then depressurized at its upper end. DCA was nearly completely removed in approximately 15 min after 0.3 of pore volume water was recovered. The recovered condensate was enriched to more than 10 times the DCA concentration of the pore water. The flexible-wall cells were heated to 110 degrees C with a lower power density of similar to 44 kW/m(3). These tests resulted in slower recovery rates, and condensate concentrations that were approximately twice the pore concentration of DCA. The concentration of DCA in the clay was reduced by two orders of magnitude after approximately 0.5 of the pore volume was removed. Boiling was inferred to occur within the clay matrix because (a) DCA concentrations were enriched; (b) pressure and temperature conditions in the clay intersected the saturated vapor pressure curve; (c) Br- was absent from all but the initial outflow; (d) change in DCA and water content was roughly uniformly distributed over the length of the cell. Fractures appeared to have formed during heating, increasing the permeability, dropping the internal pressure and enabling stripping of DCA during boiling. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Liu, Xiaoling; Murdoch, Lawrence C.; Falta, Ronald W.; Tan, Tianwu] Clemson Univ, Dept Environm Engn & Earth Sci, Clemson, SC 29634 USA. RP Liu, XL (reprint author), US EPA, Natl Risk Management Res Lab, 919 Res Dr, Ada, OK 74820 USA. EM lxlttb@gmail.com; lmurdoc@clemson.edu; faltar@clemson.edu; tantianwu@gmail.com FU Strategic Environmental Research and Development Program (SERDP) [ER-1553] FX This work was funded by the Strategic Environmental Research and Development Program (SERDP, project ER-1553). We appreciate the help of Fei Chen during development of the experimental apparatus. We thank David L. Freedman, Anne Cummings, Ken Dunn, Bob Teague, and Dave Hisz from Clemson University for assistance, and we also thank reviewers for their helpful comments. NR 36 TC 4 Z9 4 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 EI 1879-2189 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD MAR PY 2014 VL 70 BP 764 EP 778 DI 10.1016/j.ijheatmasstransfer.2013.10.052 PG 15 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA AA0VF UT WOS:000330814800075 ER PT J AU Meyer, KM Calfee, MW Wood, JP Mickelsen, L Attwood, B Clayton, M Touati, A Delafield, R AF Meyer, K. M. Calfee, M. W. Wood, J. P. Mickelsen, L. Attwood, B. Clayton, M. Touati, A. Delafield, R. TI Fumigation of a laboratory-scale HVAC system with hydrogen peroxide for decontamination following a biological contamination incident SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article ID BACILLUS-ANTHRACIS; SURFACES; SPORES; VAPOR; STERILIZATION; STEEL C1 [Meyer, K. M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Meyer, K. M.; Calfee, M. W.; Wood, J. P.; Attwood, B.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Mickelsen, L.] US EPA, Off Emergency Management, Res Triangle Pk, NC 27711 USA. [Clayton, M.; Touati, A.; Delafield, R.] Arcadis G&M, Durham, NC USA. RP Calfee, MW (reprint author), US EPA, MD E343-06 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM calfee.worth@epa.gov NR 31 TC 3 Z9 3 U1 3 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD MAR PY 2014 VL 116 IS 3 BP 533 EP 541 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AA8GV UT WOS:000331334500006 PM 24279292 ER PT J AU Pandiyaraj, KN Deshmukh, RR Mahendiran, R Su, PG Yassitepe, E Shah, I Perni, S Prokopovich, P Nadagouda, MN AF Pandiyaraj, K. Navaneetha Deshmukh, R. R. Mahendiran, R. Su, Pi-G Yassitepe, Emre Shah, Ismat Perni, Stefano Prokopovich, Polina Nadagouda, Mallikarjuna N. TI Influence of operating parameters on surface properties of RF glow discharge oxygen plasma treated TiO2/PET film for biomedical application SO MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS LA English DT Article DE RF glow discharge oxygen plasma; TiO2/PET; Surface properties; Antibacterial adhesion; Cell compatibility ID HIGH-DENSITY POLYETHYLENE; ADHESION; POLYPROPYLENE; IMPROVEMENT; COATINGS; PET AB In this paper, a thin transparent titania (TiO2) film was coated on the surface of flexible poly( ethylene terephthalate) (PET) film using the sol-gel method. The surface properties of the obtained TiO2/PET film were further improved by RF glow discharge oxygen plasma as a function of exposure time and discharge power. The changes in hydrophilicity of TiO2/PET films were analyzed by contact angle measurements and surface energy. The influence of plasma on the surface of the TiO2/PET films was analyzed by atomic force microscopy (AFM) as well as the change in chemical state and composition that were investigated by X-ray photo electron spectroscopy (XPS). The cytotoxicity of the TiO2/PET films was analyzed using human osteoblast cells and the bacterial eradication behaviors of TiO2/PET films were also evaluated against Staphylococcus bacteria. It was found that the surface roughness and incorporation of oxygen containing polar functional groups of the plasma treated TiO2/PET films increased substantially as compared to the untreated one. Moreover the increased concentration of Ti3+ on the surface of plasma treated TiO2/PET films was due to the transformation of chemical states (Ti4+ -> Ti3+). These morphological and chemical changes are responsible for enhanced hydrophilicity of the TiO2/PET films. Furthermore, the plasma treated TiO2/PET film exhibited no citotoxicity against osteoblast cells and antibacterial activity against Staphylococcus bacteria which can find application in manufacturing of biomedical devices. (C) 2013 Elsevier B.V. All rights reserved. C1 [Pandiyaraj, K. Navaneetha; Mahendiran, R.] Sri Shakthi Inst Engn & Technol, Dept Phys, Surface Engn Lab, L&T Pass, Coimbatore 641062, Tamil Nadu, India. [Deshmukh, R. R.] Inst Chem Technol, Dept Phys, Bombay 400019, Maharashtra, India. [Su, Pi-G] Chinese Culture Univ, Dept Chem, Taipei 111, Taiwan. [Yassitepe, Emre; Shah, Ismat] Univ Delaware, Dept Mat Sci & Engn, Dept Phys & Astron, Newark, DE 19716 USA. [Perni, Stefano; Prokopovich, Polina] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Cardiff CF10 3AX, S Glam, Wales. [Prokopovich, Polina] Cardiff Univ, Sch Engn, Inst Med Engn & Med Phys, Cardiff CF10 3AX, S Glam, Wales. [Nadagouda, Mallikarjuna N.] US EPA, ORD, NRMRL, WSWRD, Cincinnati, OH 45268 USA. RP Pandiyaraj, KN (reprint author), Sri Shakthi Inst Engn & Technol, Dept Phys, Surface Engn Lab, L&T Pass, Coimbatore 641062, Tamil Nadu, India. EM dr.knpr@gmail.com; Nadagouda.Mallikarjuna@epamail.epa.gov RI Perni, Stefano/B-8158-2009; OI Perni, Stefano/0000-0002-3101-0098; Prokopovich, Polina/0000-0002-5700-9570 FU Science & Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India FX One of the authors (K.N.) would like to express his sincere gratitude to the Science & Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India for providing the financial support and also expresses his deep sense of gratitude to Dr. S. Thangavelu, Chairman, Sri Shakthi Institute of Engineering and Technology for providing available facility to carry out the work in the Department and for his kind encouragement during this work. The authors acknowledge Dr. R. Udhya Kumar, Department of Zoology, Bharathiar University for assisting bacterial adhesion tests and Dr. J. Chandrasekar, Associate Professor, Sri Ramakrishna Mission Vidyala College of Arts and Science for taking thickness measurement of the samples. NR 36 TC 10 Z9 11 U1 4 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0928-4931 EI 1873-0191 J9 MAT SCI ENG C-MATER JI Mater. Sci. Eng. C-Mater. Biol. Appl. PD MAR 1 PY 2014 VL 36 BP 309 EP 319 DI 10.1016/j.msec.2013.12.018 PG 11 WC Materials Science, Biomaterials SC Materials Science GA AB0VD UT WOS:000331509300039 PM 24433917 ER PT J AU Kingston, C Zepp, R Andrady, A Boverhof, D Fehir, R Hawkins, D Roberts, J Sayre, P Shelton, B Sultan, Y Vejins, V Wohlleben, W AF Kingston, Christopher Zepp, Richard Andrady, Anthony Boverhof, Darrell Fehir, Richard Hawkins, Douglas Roberts, Justin Sayre, Philip Shelton, Betsy Sultan, Yasir Vejins, Viktor Wohlleben, Wendel TI Release characteristics of selected carbon nanotube polymer composites SO CARBON LA English DT Review ID IN-SITU POLYMERIZATION; THERMOPLASTIC POLYURETHANE; ELECTRICAL-CONDUCTIVITY; MECHANICAL-PROPERTIES; THERMAL-DEGRADATION; NANOTUBE/POLYETHYLENE NANOCOMPOSITES; PHOTODEGRADED POLYMERS; POTENTIAL RELEASE; MATRIX COMPOSITES; EPOXY COMPOSITES AB Multi-walled carbon nanotubes (MWCNTs) are commonly used in polymer formulations to improve strength, conductivity, and other attributes. A developing concern is the potential for carbon nanotube polymer nanocomposites to release nanoparticles into the environment as the polymer matrix degrades or is mechanically stressed. Here, we review characteristics related to release potential of five sets of polymer systems: epoxy, polyamide, polyurethane, polyethylene, and polycarbonate. Our review includes consideration of general characteristics and use of the polymer (as related to potential MWCNT release) and its MWCNT composites; general potential for nanomaterial release (particularly MWCNTs) due to degradation and mechanical stresses during use; and potential effects of stabilizers and plasticizers on polymer degradation. We examine UV degradation, temperature extremes, acid-base catalysis, and stresses such as sanding. Based on a high-level summary of the characteristics considered, the potential for release of MWCNT with typical, intended consumer use is expected to be low. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Kingston, Christopher] Natl Res Council Canada, Emerging Technol Div, Ottawa, ON K1A 0R6, Canada. [Zepp, Richard] US Environm Protect Agcy, Ecosyst Res Div, Natl Exposure Res Lab, Athens, GA 30605 USA. [Andrady, Anthony] N Carolina State Univ, Dept Chem & Biornol Engn, Raleigh, NC 27606 USA. [Boverhof, Darrell] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. [Fehir, Richard; Roberts, Justin] US EPA, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. [Hawkins, Douglas] Dow Chem Co USA, Spring House, PA 19477 USA. [Sayre, Philip] US EPA, Off Pollut Prevent & Tox, Risk Assessment Div, Washington, DC 20460 USA. [Shelton, Betsy] Ferrouswheel Solut, Austin, TX 78748 USA. [Sultan, Yasir] Environm Canada, Gatineau, PQ J8X 4C8, Canada. [Vejins, Viktor] Nano C Inc, Westwood, MA 02090 USA. [Wohlleben, Wendel] BASF SE, D-67056 Ludwigshafen, Germany. RP Kingston, C (reprint author), Natl Res Council Canada, Emerging Technol Div, 1200 Montreal Rd, Ottawa, ON K1A 0R6, Canada. EM Christopher.Kingston@nrc-cnrc.gc.ca; Zepp.Richard@epa.gov FU US Environmental Protection Agency; American Chemistry Council Nanotechnology Panel, Environment Canada, Health Canada; American Cleaning Institute; Society of Organic Chemical Manufacturers and Affiliates; Adhesives and Sealant Council; ILSI Research Foundation FX The assessments provided in this article represent a combination of current knowledge in the field and expert opinion from numerous stakeholder groups. The information presented is as accurate and representative as possible; however, given the level of maturity of the study, CNT release, and the complexity of CNT as a polymer additive, it is possible that other release behaviors can be observed. Experts were convened and concepts developed for this paper by the NanoRelease Consumer Products Steering Committee (http:// www.ilsi.org/ResearchFoundation/Pages/NanoRelease1.aspx). NanoRelease is funded by the US Environmental Protection Agency, the American Chemistry Council Nanotechnology Panel, Environment Canada, Health Canada, the American Cleaning Institute, the Society of Organic Chemical Manufacturers and Affiliates, the Adhesives and Sealant Council, and the ILSI Research Foundation. More than 60 experts listed on the NanoRelease CP web site from government, academia, industry, and civil society organizations have also contributed time and expertise in support of the project. We especially thank Eva Wong, U.S. EPA, and Lyubov Tsytsikova, ILSI, for their contributions to this work under the NanoRelease project, and to Christina West for editorial assistance in completing this manuscript. This article has been reviewed in accordance with the U.S. Environmental Protection Agency's (U.S. EPA) peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use by the U.S. EPA. NR 130 TC 51 Z9 53 U1 7 U2 116 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD MAR PY 2014 VL 68 BP 33 EP 57 DI 10.1016/j.carbon.2013.11.042 PG 25 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AA0UZ UT WOS:000330814200002 ER PT J AU Blazer, VS Hoffman, J Walsh, HL Braham, RP Hahn, C Collins, P Jorgenson, Z Ledder, T AF Blazer, V. S. Hoffman, J. Walsh, H. L. Braham, R. P. Hahn, C. Collins, P. Jorgenson, Z. Ledder, T. TI Health of white sucker within the St. Louis River area of concern associated with habitat usage as assessed using stable isotopes SO ECOTOXICOLOGY LA English DT Article DE White sucker; Stable isotopes; Habitat usage; Tumors ID ROACH RUTILUS-RUTILUS; ENVIRONMENTAL-STRESS FACTORS; FLOUNDER PLATICHTHYS-FLESUS; BULLHEAD AMEIURUS-NEBULOSUS; CATOSTOMUS-COMMERSONI; BROWN BULLHEAD; GREAT-LAKES; HEPATIC NEOPLASMS; CHEMICAL CONTAMINANTS; DIAGNOSTIC-CRITERIA AB In Spring 2011, 200 adult white sucker were collected in four areas of the St. Louis River area of concern (AOC), located in Minnesota and Wisconsin, USA. The areas included the upper AOC as a reference area, the upper estuary, St. Louis Bay and Superior Bay. Grossly visible abnormalities were documented and preserved for microscopic analyses, as were five to eight representative pieces of liver tissue. A piece of dorsal muscle was preserved for stable isotope analyses and otoliths removed for age determination. The incidence of raised skin lesions (mucoid plaques) was high (31 %), however, microscopically only 4.5 % of the white suckers had neoplasia (papillomas). The remaining lesions were epidermal hyperplasia. Superior Bay had the lowest percentage of skin/lip lesions (10 %), while St. Louis Bay had the highest (44 %). St. Louis Bay also had the highest incidence of skin neoplasms (12 %). No hepatocellular neoplasms were documented, however bile duct tumors were observed in 4.5 % of the suckers. Foci of cellular alteration were observed in fish from all sites except the upper AOC. Stable isotope data indicated that most of the suckers relied on the St. Louis River AOC for the majority (> 75 %) of their diet, indicating they were resident within the AOC and not in Lake Superior. The amount of diet obtained from the upper estuary was a significant predictor of skin lesion incidence. Hence, habitat use within the AOC appears to be an important risk factor for skin and possibly, liver lesions. C1 [Blazer, V. S.; Walsh, H. L.] US Geol Survey, Leetown Sci Ctr, Fish Hlth Branch, Kearneysville, WV 25430 USA. [Hoffman, J.] US EPA, Mid Continent Ecol Div, Duluth, MN USA. [Braham, R. P.; Hahn, C.] W Virginia Univ, Coll Agr & Forestry, Morgantown, WV 26506 USA. [Collins, P.] Minnesota Dept Nat Resources, Grand Rapids, MN USA. [Jorgenson, Z.] US Fish & Wildlife Serv, Twin Cities Ecol Serv Field Off, Bloomington, MN 55425 USA. [Ledder, T.] Univ Wisconsin, Lake Super Natl Estuarine Res Reserve, Superior, WI USA. RP Blazer, VS (reprint author), US Geol Survey, Leetown Sci Ctr, Fish Hlth Branch, 11649 Leetown Rd, Kearneysville, WV 25430 USA. EM vblazer@usgs.gov; Hoffman.joel@epa.gov; hwalsh@usgs.gov; ryan.braham@hotmail.com; cassidy.hahn@gmail.com; Pat.collins@state.mn.us; Zachary_jorgenson@fws.gov; Tracey.ledder@ces.uwex.edu OI H. Shaw, Cassidy/0000-0003-2639-1241 FU Great Lakes Restoration Initiative (through the Fish and Wildlife Service Contaminants program); U.S. Geological Survey's Contaminant Biology (Environmental Health), Fisheries (Ecosystems) and Cooperative Fish and Wildlife programs; U.S. Environmental Protection Agency; U.S. Government FX This project was jointly funded by the Great Lakes Restoration Initiative (through the Fish and Wildlife Service Contaminants program), the U.S. Geological Survey's Contaminant Biology (Environmental Health), Fisheries (Ecosystems) and Cooperative Fish and Wildlife programs and the U.S. Environmental Protection Agency. Assistance from Wisconsin DNR, Minnesota DNR, U.S. Fish and Wildlife Service, the Minnesota Land Trust and the Fond du Lac Band of Lake Superior Chippewa is gratefully acknowledged. We thank Glenn Miller, Rich Davis, Sara Werner, Brian Borkholder, John Lindgren and Daryl Peterson for assistance with fish collections and Darlene Bowling, Kathy Spring and Megan McGovern for laboratory technical assistance. The views expressed herein are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency or U.S. Fish and Wildlife Service. Use of trade names is for identification purposes only and does not imply endorsement by the U.S. Government. NR 82 TC 2 Z9 2 U1 1 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 EI 1573-3017 J9 ECOTOXICOLOGY JI Ecotoxicology PD MAR PY 2014 VL 23 IS 2 BP 236 EP 251 DI 10.1007/s10646-013-1167-5 PG 16 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AA3AT UT WOS:000330966000012 PM 24370817 ER PT J AU Lytle, DA Sorg, T Wang, LL Chen, A AF Lytle, Darren A. Sorg, Thomas Wang, Lili Chen, Abe TI The accumulation of radioactive contaminants in drinking water distribution systems SO WATER RESEARCH LA English DT Article DE Distribution system; Radium; Radioactivity; Thorium; Water ID RELEASE; DEPOSITS; SCALES; IRON AB The accumulation of trace contaminants in drinking water distribution system sediment and scales has been documented, raising concerns that the subsequent release of the contaminants back to the water is a potential human exposure pathway. Radioactive contaminants are of concern because of their known health effects and because of their persistence within associated distribution system materials. The objective of this work was to measure the amount of a number of radioactive contaminants (radium, thorium, and uranium isotopes, and gross alpha and beta activity) in distribution solids collected from water systems in four states (Wisconsin, Illinois, Minnesota, and Texas). The water utilities chosen had measurable levels of radium in their source waters. In addition, 19 other elements in the solids were quantified. Water systems provided solids primarily collected during routine fire hydrant flushing. Iron was the dominant element in nearly all of the solids and was followed by calcium, phosphorus, magnesium, manganese, silicon, aluminum and barium in descending order. Gross alpha and beta radiation averaged 255 and 181 pCi/g, and were as high as 1602 and 1169 pCi/g, respectively. Total radium, thorium and uranium averaged 143,40 and 6.4 pCi/g, respectively. Radium-226 and -228 averaged 74 and 69 pCi/g, and were as high as 250 and 351 pCi/g, respectively. Published by Elsevier Ltd. C1 [Lytle, Darren A.; Sorg, Thomas] US EPA, ORD, NRMRL, WSWRD, Cincinnati, OH 45268 USA. [Wang, Lili] US EPA, OW, GWDW, SRMD, Washington, DC 20460 USA. [Chen, Abe] ALSA Tech LLC, Powell, OH 43065 USA. RP Lytle, DA (reprint author), US EPA, ORD, NRMRL, WSWRD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM lytle.darren@epa.gov NR 19 TC 11 Z9 11 U1 5 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD MAR 1 PY 2014 VL 50 BP 396 EP 407 DI 10.1016/j.watres.2013.10.050 PG 12 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AA2FD UT WOS:000330909600038 PM 24275108 ER PT J AU Hill, BH Kolka, RK McCormick, FH Starry, MA AF Hill, Brian H. Kolka, Randall K. McCormick, Frank H. Starry, Matthew A. TI A synoptic survey of ecosystem services from headwater catchments in the United States SO ECOSYSTEM SERVICES LA English DT Article DE C sequestration; Climate regulation; Denitrification; Headwater catchments; Water purification; Water supply ID DOWNSTREAM WATER-QUALITY; N-P STOICHIOMETRY; CARBON SEQUESTRATION; DENITRIFICATION; NITROGEN; FORESTS; STREAMS; SOIL; MANAGEMENT; BENEFITS AB Ecosystem production functions for water supply, climate regulation, and water purification were estimated for 568 headwater streams and their catchments. Results are reported for nine USA ecoregions. Headwater streams represented 74-80% of total catchment stream length. Water supply per unit catchment area was highest in the Northern Appalachian Mountains ecoregion and lowest in the Northern Plains. C, N, and P sequestered in trees were highest in Northern and Southern Appalachian and Western Mountain catchments, but C, N, and P sequestered in soils were highest in the Upper Midwest ecoregion. Catchment denitrification was highest in the Western Mountains. In-stream denitrification was highest in the Temperate Plains. Ecological production functions paired with published economic values for theses services revealed the importance of mountain catchments for water supply, climate regulation, and water purification per unit catchment area The larger catchment sizes of the plains ecoregions resulted in their higher economic value compared to the other ecoregions. The combined potential economic value across headwater catchments was INT $14,000 ha(-1) yr(-1), or INT $30 million yr(-1) per catchment. The economic importance of headwater catchments is even greater considering that our study catchments statistically represent more than 2 million headwater catchments in the continental United States. Published by Elsevier B.V. C1 [Hill, Brian H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Kolka, Randall K.] US Forest Serv, No Res Stn, Ctr Res Ecosyst Change, Grand Rapids, MN 55744 USA. [McCormick, Frank H.] US Forest Serv, Rocky Mt Res Stn, Air Water & Aquat Environm Sci Program, Boise, ID 83702 USA. [Starry, Matthew A.] SRA Int, Fairfax, VA 22033 USA. RP Hill, BH (reprint author), US EPA, NHEERL, MED, 6201 Congdon Blvd, Duluth, MN 55304 USA. EM hill.brian@epa.gov FU USEPA Office of Water FX The USEPA Office of Water sponsored the National Rivers and Streams Assessment, AR Olsen supervised the creation of the survey design. We are indebted to the numerous state, federal, and contractor field crews and laboratory staff who collected and analyzed the NRSA samples. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency, the US Forest Service, or SRA International. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 73 TC 2 Z9 2 U1 2 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-0416 J9 ECOSYST SERV JI Ecosyst. Serv. PD MAR PY 2014 VL 7 BP 106 EP 115 DI 10.1016/j.ecoser.2013.12.004 PG 10 WC Ecology; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA CU6RM UT WOS:000363660700012 ER PT J AU Voytek, EB Drenkelfuss, A Day-Lewis, FD Healy, R Lane, JW Werkema, D AF Voytek, Emily B. Drenkelfuss, Anja Day-Lewis, Frederick D. Healy, Richard Lane, John W., Jr. Werkema, Dale TI 1DTempPro: Analyzing Temperature Profiles for Groundwater/Surface-water Exchange SO GROUNDWATER LA English DT Article ID FLUX; HEAT AB A new computer program, 1DTempPro, is presented for the analysis of vertical one-dimensional (1D) temperature profiles under saturated flow conditions. 1DTempPro is a graphical user interface to the U.S. Geological Survey code Variably Saturated 2-Dimensional Heat Transport (VS2DH), which numerically solves the flow and heat-transport equations. Pre- and postprocessor features allow the user to calibrate VS2DH models to estimate vertical groundwater/ surface-water exchange and also hydraulic conductivity for cases where hydraulic head is known. C1 [Voytek, Emily B.; Day-Lewis, Frederick D.; Lane, John W., Jr.] US Geol Survey, Off Groundwater, Branch Geophys, Storrs, CT 06269 USA. [Drenkelfuss, Anja] Univ Bonn, Dept Geodynam & Geophys, D-53115 Bonn, Germany. [Healy, Richard] US Geol Survey, Natl Res Program, Denver, CO 80225 USA. [Werkema, Dale] US EPA, Las Vegas, NV 89119 USA. RP Voytek, EB (reprint author), US Geol Survey, Off Groundwater, Branch Geophys, 11 Sherman Pl,Unit 5015, Storrs, CT 06269 USA. EM ebvoytek@usgs.gov OI Day-Lewis, Frederick/0000-0003-3526-886X FU U.S. Environmental Protection Agency [EP10D000782]; USGS FX The authors are grateful for useful comments from USGS colleagues Jeannie Barlow, Martin Briggs, and Cheryl Miller. We acknowledge constructive comments from four anonymous reviewers. The first author also is grateful to Ethan Yang (U. Massachusetts, Amherst) for advice on development of GUIs. The second author is grateful to Andreas Kemna for supporting an internship at the USGS while studying at University of Bonn, Germany. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. government. This work was supported by the U.S. Environmental Protection Agency under contract EP10D000782, and the USGS Toxic Substances Hydrology and Groundwater Resources Programs. NR 12 TC 10 Z9 10 U1 1 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-467X EI 1745-6584 J9 GROUNDWATER JI Groundwater PD MAR-APR PY 2014 VL 52 IS 2 BP 298 EP 302 DI 10.1111/gwat.12051 PG 5 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA AZ1CP UT WOS:000347978200016 PM 23550960 ER PT J AU Voelker, SL Meinzer, FC Lachenbruch, B Brooks, JR Guyette, RP AF Voelker, Steven L. Meinzer, Frederick C. Lachenbruch, Barbara Brooks, J. Renee Guyette, Richard P. TI Drivers of radial growth and carbon isotope discrimination of bur oak (Quercus macrocarpa Michx.) across continental gradients in precipitation, vapour pressure deficit and irradiance SO PLANT CELL AND ENVIRONMENT LA English DT Article DE CO2; dendrochronology; drought; growth; humidity; light; stable isotopes; stomata ID WATER-USE EFFICIENCY; TREE-RING CELLULOSE; MESOPHYLL DIFFUSION CONDUCTANCE; BREA TAR PITS; GAS-EXCHANGE; CO2 DIFFUSION; C-13/C-12 VARIATIONS; STOMATAL RESPONSES; STABLE-ISOTOPES; ATMOSPHERIC CO2 AB Tree-ring characteristics are commonly used to reconstruct climate variables, but divergence from the assumption of a single biophysical control may reduce the accuracy of these reconstructions. Here, we present data from bur oaks (Quercus macrocarpaMichx.) sampled within and beyond the current species bioclimatic envelope to identify the primary environmental controls on ring-width indices (RWIs) and carbon stable isotope discrimination (C-13) in tree-ring cellulose. Variation in C-13 and RWI was more strongly related to leaf-to-air vapour pressure deficit (VPD) at the centre and western edge of the range compared with the northern and wettest regions. Among regions, C-13 of tree-ring cellulose was closely predicted by VPD and light responses of canopy-level C-13 estimated using a model driven by eddy flux and meteorological measurements (R-2=0.96, P=0.003). RWI and C-13 were positively correlated in the drier regions, while they were negatively correlated in the wettest region. The strength and direction of the correlations scaled with regional VPD or the ratio of precipitation to evapotranspiration. Therefore, the correlation strength between RWI and C-13 may be used to infer past wetness or aridity from paleo wood by determining the degree to which carbon gain and growth have been more limited by moisture or light. C1 [Voelker, Steven L.] Southern Oregon Univ, Dept Biol, Ashland, OR 97520 USA. [Meinzer, Frederick C.] US Forest Serv, Forestry Sci Lab, USDA, Corvallis, OR 97331 USA. [Lachenbruch, Barbara] Oregon State Univ, Dept Wood Sci & Engn, Corvallis, OR 97331 USA. [Brooks, J. Renee] US EPA, Natl Hlth & Environm Effects Res Lab NHEERL, Western Ecol Div, Corvallis, OR 97333 USA. [Guyette, Richard P.] Univ Missouri, Dept Forestry, Columbia, MO 65211 USA. RP Voelker, SL (reprint author), Southern Oregon Univ, Dept Biol, 1250 Siskiyou Blvd, Ashland, OR 97520 USA. EM voelkerst@sou.edu RI Meinzer, Frederick/C-3496-2012; Voelker, Steven/O-2909-2014; OI Brooks, Renee/0000-0002-5008-9774 FU National Science Foundation [DEB-0743882] FX We appreciate the assistance provided by Lara Laubli in measuring and cross-dating tree rings, Mike Messier in excising tree rings, Kristen Falk in conducting cellulose extractions and Lin Roden for verifying the accuracy of the 13C/12C ratios at SOU. We are grateful to Dennis Baldocchi for providing us canopy-level Delta13C responses to VPD and PFD. Steve Leavitt and Julia Burton provided insight that improved this manuscript. Helpful comments were also provided by Graham Farquhar and four anonymous reviewers. This research was supported by the National Science Foundation grant #DEB-0743882. This manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and it has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 103 TC 8 Z9 8 U1 7 U2 60 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0140-7791 EI 1365-3040 J9 PLANT CELL ENVIRON JI Plant Cell Environ. PD MAR PY 2014 VL 37 IS 3 BP 766 EP 779 DI 10.1111/pce.12196 PG 14 WC Plant Sciences SC Plant Sciences GA 292QV UT WOS:000329918100017 PM 24004466 ER PT J AU Nickel, D Schoenfelder, W Medearis, D Dolowitz, DP Keeley, M Shuster, W AF Nickel, Darla Schoenfelder, Wenke Medearis, Dale Dolowitz, David P. Keeley, Melissa Shuster, William TI German experience in managing stormwater with green infrastructure SO JOURNAL OF ENVIRONMENTAL PLANNING AND MANAGEMENT LA English DT Article ID UNITED-STATES; MANAGEMENT; IMPEDIMENTS AB This paper identifies and describes experience with green' stormwater management practices in Germany. It provides the context in which developments took place and extracts lessons learned to inform efforts of other countries in confronting urban stormwater challenges. Our findings show that an integrated environmental planning approach helps to balance environmental and urban development. Further, the transformation to a mixed grey and green infrastructure necessitates both a quantifiable long-term goal and a suite of policies to incentivise green infrastructure and support implementation. Finally, public authorities must assume leadership while enabling the participation of stakeholder groups in the transformation process. C1 [Nickel, Darla] Inst Ecol, D-10717 Berlin, Germany. [Schoenfelder, Wenke] Hamburg Wasser, D-20539 Hamburg, Germany. [Medearis, Dale] Northern Virginia Reg Commiss, Fairfax, VA 22031 USA. [Dolowitz, David P.] Univ Liverpool, Dept Polit, Liverpool L69 7ZT, Merseyside, England. [Keeley, Melissa] George Washington Univ, Dept Geog, Washington, DC 20052 USA. [Shuster, William] US EPA, Cincinnati, OH 45268 USA. RP Nickel, D (reprint author), Inst Ecol, Pfalzburger Str 43-44, D-10717 Berlin, Germany. EM darla.nickel@ecologic.eu NR 59 TC 4 Z9 4 U1 6 U2 51 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0964-0568 EI 1360-0559 J9 J ENVIRON PLANN MAN JI J. Environ. Plan. Manag. PD MAR 1 PY 2014 VL 57 IS 3 BP 403 EP 423 DI 10.1080/09640568.2012.748652 PG 21 WC Environmental Studies SC Environmental Sciences & Ecology GA 288IG UT WOS:000329604600006 ER PT J AU Wolf, CJ Rider, CV Lau, C Abbott, BD AF Wolf, Cynthia J. Rider, Cynthia V. Lau, Christopher Abbott, Barbara D. TI Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-a activation SO TOXICOLOGY LA English DT Article DE Perfluoroalkyl acids; PFOA; Mixtures; Additivity; PPAR alpha ID EXPOSED MOUSE FETUSES; SPRAGUE-DAWLEY RATS; PPAR-ALPHA; PERFLUOROOCTANOIC ACID; NUCLEAR RECEPTORS; CELL-PROLIFERATION; DIETARY EXPOSURE; POTASSIUM PERFLUOROOCTANESULFONATE; HEPATOCELLULAR HYPERTROPHY; TRANSCRIPTIONAL ACTIVATION AB Perfluoroalkyl acids (PFAAs) are found globally in the environment, detected in humans and wildlife, and are typically present as mixtures of PFAA congeners. Mechanistic studies have found that responses to PFAAs are mediated in part by PPAR alpha. Our previous studies showed that individual PFAAs activate PPAR alpha transfected into COS-1 cells. The goal of the current study was to determine if binary combinations of perfluorooctanoic acid (PFOA) and another PFAA act in an additive fashion to activate PPAR alpha in the mouse one-hybrid in vitro model. COS-1 cells were transiently transfected with mouse PPAR alpha luciferase reporter construct and exposed to either vehicle control (0.1% DMSO or water), PPAR alpha agonist (VVY14643, 10 mu M), PFOA at 1-128 mu M, perfluorononanoic acid (PFNA) at 1-128 mu M, perfluorohexanoic acid (PFHxA) at 8-1024 mu M, perfluorooctane sulfonate (PFOS) at 4-384 mu M or perfluorohexane sulfonate (PFHxS) at 8-2048 mu M to generate sigmoidal concentration-response curves. In addition, cells were exposed to binary combinations of PFOA + either PFNA, PFHxA, PFOS or PFHxS in an 8 x 8 factorial design. The concentration-response data for individual chemicals were fit to sigmoidal curves and analyzed with nonlinear regression to generate EC(50)s and Hillslopes, which were used in response-addition and concentration-addition models to calculate predicted responses for mixtures in the same plate. All PFOA + PFAA combinations produced concentration-response curves that were closely aligned with the predicted curves for both response addition and concentration addition at low concentrations. However, at higher concentrations of all chemicals, the observed response curves deviated from the predicted models of additivity. We conclude that binary combinations of PFAAs behave additively at the lower concentration ranges in activating PPAR alpha in this in vitro system. Published by Elsevier Ireland Ltd. C1 [Wolf, Cynthia J.; Lau, Christopher; Abbott, Barbara D.] US EPA, Dev Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,ORD, Res Triangle Pk, NC 27711 USA. [Rider, Cynthia V.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. RP Wolf, CJ (reprint author), US EPA, NHEERL, TAD, MD-67,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM wolf.cynthiaj@epa.gov NR 52 TC 7 Z9 7 U1 7 U2 27 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD FEB 28 PY 2014 VL 316 BP 43 EP 54 DI 10.1016/j.tox.2013.12.002 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AC3SG UT WOS:000332440900006 PM 24374136 ER PT J AU Georgescu, M Morefield, PE Bierwagen, BG Weaver, CP AF Georgescu, Matei Morefield, Philip E. Bierwagen, Britta G. Weaver, Christopher P. TI Urban adaptation can roll back warming of emerging megapolitan regions SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE sustainability; mitigation; land-use change; urbanization; urban climate ID LAND-USE CHANGE; CLIMATE; BIODIVERSITY; PREDICTION; EXPANSION; LANDSCAPE; IMPACTS; CITIES; MODEL AB Modeling results incorporating several distinct urban expansion futures for the United States in 2100 show that, in the absence of any adaptive urban design, megapolitan expansion, alone and separate from greenhouse gas-induced forcing, can be expected to raise near-surface temperatures 1-2 degrees C not just at the scale of individual cities but over large regional swaths of the country. This warming is a significant fraction of the 21st century greenhouse gas-induced climate change simulated by global climate models. Using a suite of regional climate simulations, we assessed the efficacy of commonly proposed urban adaptation strategies, such as green, cool roof, and hybrid approaches, to ameliorate the warming. Our results quantify how judicious choices in urban planning and design cannot only counteract the climatological impacts of the urban expansion itself but also, can, in fact, even offset a significant percentage of future greenhouse warming over large scales. Our results also reveal tradeoffs among different adaptation options for some regions, showing the need for geographically appropriate strategies rather than one size fits all solutions. C1 [Georgescu, Matei] Arizona State Univ, Global Inst Sustainabil, Sch Geog Sci & Urban Planning, Tempe, AZ 85287 USA. [Morefield, Philip E.; Bierwagen, Britta G.; Weaver, Christopher P.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. RP Georgescu, M (reprint author), Arizona State Univ, Global Inst Sustainabil, Sch Geog Sci & Urban Planning, Tempe, AZ 85287 USA. EM Matei.Georgescu@asu.edu RI Georgescu, Matei/G-5442-2011; Weaver, Christopher/G-3714-2010 OI Weaver, Christopher/0000-0003-4016-5451 FU National Science Foundation [EAR-1204774] FX We thank B. L. Turner, A. Brazel, C. A. Miller, and S. Julius for valued discussions. We also thank two anonymous reviewers, whose comments have led to an improved paper. We also thank B. Trapido-Lurie for assistance with figure preparations. M. G. was supported by National Science Foundation Grant EAR-1204774. NR 35 TC 81 Z9 83 U1 9 U2 98 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD FEB 25 PY 2014 VL 111 IS 8 BP 2909 EP 2914 DI 10.1073/pnas.1322280111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AC0JP UT WOS:000332180900018 PM 24516126 ER PT J AU Virkutyte, J Al-Abed, SR Choi, H Bennett-Stamper, C AF Virkutyte, Jurate Al-Abed, Souhail R. Choi, Hyeok Bennett-Stamper, Christina TI Distinct structural behavior and transport of TiO2 nano- and nanostructured particles in sand SO COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS LA English DT Article DE TiO2; Nanoparticles; Nanostructured particles; Attachment coefficient; Transport; DLVO ID SATURATED POROUS-MEDIA; TITANIUM-DIOXIDE NANOPARTICLES; METAL-OXIDE NANOPARTICLES; SECONDARY ENERGY MINIMUM; IRON NANOPARTICLES; COLLOID TRANSPORT; ACTIVATED CARBON; IONIC-STRENGTH; AGGREGATION; DEPOSITION AB Environmental impact of TiO2 particles along with other widely-used nanomaterials as a new class of contaminants has recently emerged. Due to the lack of detailed information and proper understanding of their properties as a result of synthesis (nanoparticles vs nanostructured particles), there is a disagreement in interpreting their behavior and transport in the environment. In this study, we discuss the characteristic retention and breakthrough of commercially available TiO2 particles with unique nanoscale structure, i.e. well-defined nanoparticles (NPs) and nanostructured particles (NSPs), through sand under various reaction environments. NPs such as P-25 (30 nm) were completely different in terms of their physicochemical structure from NSPs, which may be more proper to be considered as micro or bulk TiO2 particles. Such observation undoubtedly evidenced an important finding that encapsulating NPs with stabilizers such as carboxymethyl cellulose abundant in the environment and changing their surface chemistry with pH and ionic strength greatly affected their dispersion in the aqueous phase and mobility through a clean quartz medium, while those strategies were not so effective for NSPs. Therefore, it is apparent that the terms NPs and NSPs should be more strictly differentiated in their use in order to avoid any confusion in assessing their mobility in the environment. Published by Elsevier B.V. C1 [Virkutyte, Jurate] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.; Bennett-Stamper, Christina] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Choi, Hyeok] Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA. EM Virkutyte.Jurate@epa.gov; al-abed.souhail@epa.gov FU U.S. Environmental Protection Agency (EPA), Cincinnati, Ohio; University of Texasat Arlington FX This research was funded by and conducted at the National Risk Management Research Laboratory of U.S. Environmental Protection Agency (EPA), Cincinnati, Ohio. Dr. Choi appreciated the partial financial support for this work from the University of Texasat Arlington through the 2010-2011 Faculty Research Enhancement Program. This paper has not been subjected to internal policy review of the U.S. EPA. Therefore, the research results do not necessarily reflect the views of the agency or its policy. Mention of trade names and commercial products does not constitute endorsement or recommendation for use. NR 49 TC 2 Z9 2 U1 4 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7757 EI 1873-4359 J9 COLLOID SURFACE A JI Colloid Surf. A-Physicochem. Eng. Asp. PD FEB 20 PY 2014 VL 443 BP 188 EP 194 DI 10.1016/j.colsurfa.2013.11.004 PG 7 WC Chemistry, Physical SC Chemistry GA AQ0VR UT WOS:000342501300027 ER PT J AU Martinovic-Weigelt, D Mehinto, AC Ankley, GT Denslow, ND Barber, LB Lee, KE King, RJ Schoenfuss, HL Schroeder, AL Villeneuve, DL AF Martinovic-Weigelt, Dalma Mehinto, Alvine C. Ankley, Gerald T. Denslow, Nancy D. Barber, Larry B. Lee, Kathy E. King, Ryan J. Schoenfuss, Heiko L. Schroeder, Anthony L. Villeneuve, Daniel L. TI Transcriptomic Effects-Based Monitoring for Endocrine Active Chemicals: Assessing Relative Contribution of Treated Wastewater to Downstream Pollution SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ARYL-HYDROCARBON-RECEPTOR; GENE-EXPRESSION; ESTROGEN; EFFLUENT; FISH; DISRUPTION; ACTIVATION; MECHANISM; TOXICITY; PATHWAYS AB The present study investigated whether a combination of targeted analytical chemistry information with unsupervised, data-rich biological methodology (i.e., transcriptomics) could be utilized to evaluate relative contributions of wastewater treatment plant (WWTP) effluents to biological effects. The effects of WWTP effluents on fish exposed to ambient, receiving waters were studied at three locations with distinct WWTP and watershed characteristics. At each location, 4 d exposures of male fathead minnows to the WWTP effluent and upstream and downstream ambient waters were conducted. Transcriptomic analyses were performed on livers using 15 000 feature microarrays, followed by a canonical pathway and gene set enrichment analyses. Enrichment of gene sets indicative of teleost brain pituitary gonadal hepatic (BPGH) axis function indicated that WWTPs serve as an important source of endocrine active chemicals (EACs) that affect the BPGH axis (e.g., cholesterol and steroid metabolism were altered). The results indicated that transcriptomics may even pinpoint pertinent adverse outcomes (i.e., liver vacuolization) and groups of chemicals that preselected chemical analytes may miss. Transcriptomic Effects-Based monitoring was capable of distinguishing sites, and it reflected chemical pollution gradients, thus holding promise for assessment of relative contributions of point sources to pollution and the efficacy of pollution remediation. C1 [Martinovic-Weigelt, Dalma; King, Ryan J.] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. [Mehinto, Alvine C.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Ankley, Gerald T.; Schroeder, Anthony L.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA. [Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. [Barber, Larry B.] US Geol Survey, Branch Reg Res, Boulder, CO 80303 USA. [Lee, Kathy E.] US Geol Survey, Water Mission Area, Mounds View, MN 55744 USA. [Schoenfuss, Heiko L.] St Cloud State Univ, Dept Biol Sci, St Cloud, MN 56301 USA. RP Martinovic-Weigelt, D (reprint author), Univ St Thomas, Dept Biol, Mail OWS 390,2115 Summit Ave, St Paul, MN 55105 USA. EM dalma@stthomas.edu OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU MN Pollution Control Agency; MN Clean Water Fund; USGS; Oak Ridge Institute for Science and Education; US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program, Region 5, Great Lakes National Program Office) FX Funded by MN Pollution Control Agency, MN Clean Water Fund, USGS, Oak Ridge Institute for Science and Education, US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program, Region 5, Great Lakes National Program Office). We thank Mark Ferrey, Brent Weigelt, Germain Walseth, Jascha Marchuk, and the WWTP staff. NR 40 TC 19 Z9 19 U1 3 U2 52 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 18 PY 2014 VL 48 IS 4 BP 2385 EP 2394 DI 10.1021/es404027n PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AB4QD UT WOS:000331774100036 PM 24409827 ER PT J AU Skelton, DM Ekman, DR Martinovic-Weigelt, D Ankley, GT Villeneuve, DL Teng, Q Collette, TW AF Skelton, D. M. Ekman, D. R. Martinovic-Weigelt, D. Ankley, G. T. Villeneuve, D. L. Teng, Q. Collette, T. W. TI Metabolomics for in Situ Environmental Monitoring of Surface Waters Impacted by Contaminants from Both Point and Nonpoint Sources SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MINNOWS PIMEPHALES-PROMELAS; RESPONSES; METABOLITES; MIXTURE; NMR; EXPOSURE; EFFLUENT; PROFILE; MODEL AB We investigated the efficacy of metabolomics for field-monitoring of fish exposed to wastewater treatment plant (WWTP) effluents and nonpoint sources of chemical contamination. Lab-reared male fathead minnows (Pimephales promelas, FHM) were held in mobile monitoring units and exposed on-location to surface waters upstream and downstream of the effluent point source, as well as to the actual effluent at three different WWTP sites in Minnesota. After four days of exposure, livers were collected, extracted, and analyzed by H-1 NMR spectroscopy and GC-MS to characterize responses of the hepatic metabolome. Multivariate statistical analysis revealed distinct metabolite profile changes in response to effluent exposure from each of the three WWTPs. Differences among locations (i.e., upstream, downstream, and effluent) within each of the three sites were also identified. These observed differences comport with land-use and WWTP characteristics at the study sites. For example, at one of the sites, the metabolomic analyses suggested a positive interactive response from exposure to WWTP effluent and nearby nonpoint (likely agricultural related) contamination. These findings demonstrate the utility of metabolomics as a field-based technique for monitoring the exposure of fish to impacted surface waters. C1 [Skelton, D. M.; Ekman, D. R.; Teng, Q.; Collette, T. W.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Martinovic-Weigelt, D.] Univ St Thomas, St Paul, MN 55105 USA. [Ankley, G. T.; Villeneuve, D. L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA. RP Skelton, DM (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. EM skelton.david@epa.gov; collette.tim@epa.gov OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 NR 35 TC 10 Z9 11 U1 7 U2 72 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 18 PY 2014 VL 48 IS 4 BP 2395 EP 2403 DI 10.1021/es404021f PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AB4QD UT WOS:000331774100037 PM 24328273 ER PT J AU Berninger, JP Martinovic-Weigelt, D Garcia-Reyero, N Escalon, L Perkins, EJ Ankley, GT Villeneuve, DL AF Berninger, Jason P. Martinovic-Weigelt, Dalma Garcia-Reyero, Natalia Escalon, Lynn Perkins, Edward J. Ankley, Gerald T. Villeneuve, Daniel L. TI Using Transcriptomic Tools to Evaluate Biological Effects Across Effluent Gradients at a Diverse Set of Study Sites in Minnesota, USA SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LARGE GENE LISTS; RISK-ASSESSMENT; BISPHENOL-A; IMPACTS; ECOTOXICOLOGY; EXPRESSION; SYSTEM; MODEL; FISH AB The aim of this study was to explore the utility of "omics" approaches in monitoring aquatic environments where complex, often unknown stressors make chemical-specific risk assessment untenable. We examined changes in the fathead minnow (Pimephales promelas) ovarian transcriptome following 4-day exposures conducted at three sites in Minnesota (MN, USA). Within each site, fish were exposed to water from three locations along a spatial gradient relative to a wastewater treatment plant (WWTP) discharge. After exposure, site-specific impacts on gene expression in ovaries were assessed. Using an intragradient point of comparison, biological responses specifically associated with the WWTP effluent were identified using functional enrichment analyses. Fish exposed to water from locations downstream of the effluent discharges exhibited many transcriptomic responses in common with those exposed to the effluent, indicating that effects of the discharge do not fully dissipate downstream. Functional analyses showed a range of biological pathways impacted through effluent exposure at all three sites. Several of those impacted pathways at each site could be linked to potential adverse reproductive outcomes associated with the hypothalamic pituitary gonadal (HPG) axis in female fathead minnows, specifically signaling pathways associated with oocyte meiosis, TGF-beta signaling, gonadotropin-releasing hormone (GnRH) and epidermal growth factor receptor family (ErbB), and gene sets associated with cyclin B-1 and metalloproteinase. The utility of this approach comes from the ability to identify biological responses to pollutant exposure, particularly those that can be tied to adverse outcomes at the population level and those that identify molecular targets for future studies. C1 [Berninger, Jason P.] US EPA, Natl Res Council, Duluth, MN 55804 USA. [Martinovic-Weigelt, Dalma] Univ St Thomas, St Paul, MN 55105 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA. [Escalon, Lynn; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. RP Berninger, JP (reprint author), US EPA, Natl Res Council, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Berninger.Jason@epa.gov RI Berninger, Jason/O-2401-2016; OI Berninger, Jason/0000-0003-3045-7899; Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU US Army Environmental Quality Research Program [BAA 11-4838] FX The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency. This work was partly funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. The authors thank Kathy Lee (USGS), Heiko Schoenfuss (St. Cloud State University), Leah Wehmas, and their co-workers for their efforts in collecting samples that were used in this study and Anthony Schroeder for helpful comments on the manuscript. NR 29 TC 12 Z9 12 U1 3 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 18 PY 2014 VL 48 IS 4 BP 2404 EP 2412 DI 10.1021/es4040254 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AB4QD UT WOS:000331774100038 PM 24433150 ER EF